-- dump date 20111121_010730 -- class Genbank::misc_feature -- table misc_feature_note -- id note 114615000001 chromosomal replication initiation protein; Reviewed; Region: dnaA; PRK00149 114615000002 hypothetical protein; Validated; Region: PRK06672 114615000003 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes...; Region: AAA; cd00009 114615000004 Walker A motif; other site 114615000005 ATP binding site [chemical binding]; other site 114615000006 Walker B motif; other site 114615000007 arginine finger; other site 114615000008 C-terminal domain of bacterial DnaA proteins. The DNA-binding C-terminal domain of DnaA contains a helix-turn-helix motif that specifically interacts with the DnaA box, a 9-mer motif that occurs repetitively in the replication origin oriC. Multiple...; Region: Bac_DnaA_C; cd06571 114615000009 DnaA box-binding interface [nucleotide binding]; other site 114615000010 DNA polymerase III subunit beta; Validated; Region: PRK05643 114615000011 Beta clamp domain. The beta subunit (processivity factor) of DNA polymerase III holoenzyme, refered to as the beta clamp, forms a ring shaped dimer that encircles dsDNA (sliding clamp) in bacteria. The beta-clamp is structurally similar to the...; Region: beta_clamp; cd00140 114615000012 putative DNA binding surface [nucleotide binding]; other site 114615000013 dimer interface [polypeptide binding]; other site 114615000014 beta-clamp/clamp loader binding surface; other site 114615000015 beta-clamp/translesion DNA polymerase binding surface; other site 114615000016 recombination protein F; Reviewed; Region: recF; PRK00064 114615000017 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 114615000018 Walker A/P-loop; other site 114615000019 ATP binding site [chemical binding]; other site 114615000020 Q-loop/lid; other site 114615000021 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 114615000022 ABC transporter signature motif; other site 114615000023 Walker B; other site 114615000024 D-loop; other site 114615000025 H-loop/switch region; other site 114615000026 DNA gyrase subunit B; Provisional; Region: gyrB; PRK14939 114615000027 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075 114615000028 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are...; Region: TopoII_Trans_DNA_gyrase; cd00822 114615000029 anchoring element; other site 114615000030 dimer interface [polypeptide binding]; other site 114615000031 ATP binding site [chemical binding]; other site 114615000032 TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of...; Region: TOPRIM_TopoIIA_GyrB; cd03366 114615000033 active site 114615000034 putative metal-binding site [ion binding]; other site 114615000035 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 114615000036 UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Validated; Region: PRK09369 114615000037 UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555 114615000038 hinge; other site 114615000039 active site 114615000040 Protein of unknown function (DUF2867); Region: DUF2867; pfam11066 114615000041 Fatty acid hydroxylase superfamily; Region: FA_hydroxylase; cl01132 114615000042 transcriptional regulator EpsA; Region: EpsA; TIGR03020 114615000043 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors...; Region: LuxR_C_like; cd06170 114615000044 DNA binding residues [nucleotide binding] 114615000045 dimerization interface [polypeptide binding]; other site 114615000046 multidrug efflux protein; Reviewed; Region: PRK01766 114615000047 MatE; Region: MatE; cl10513 114615000048 MatE; Region: MatE; cl10513 114615000049 Fusaric acid resistance protein family; Region: FUSC; pfam04632 114615000050 MmgE/PrpD family; Region: MmgE_PrpD; cl00912 114615000051 Beta-lactamase; Region: Beta-lactamase; cl01009 114615000052 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 114615000053 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 114615000054 Pirin-related protein [General function prediction only]; Region: COG1741 114615000055 Cupin domain; Region: Cupin_2; cl09118 114615000056 Pirin C-terminal cupin domain; Region: Pirin_C; pfam05726 114615000057 non-metazoan 5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide (SAICAR) synthase; Region: SAICAR_synt_Sc; cd01414 114615000058 ATP binding site [chemical binding]; other site 114615000059 active site 114615000060 substrate binding site [chemical binding]; other site 114615000061 LysR family transcriptional regulator; Provisional; Region: PRK14997 114615000062 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 114615000063 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 114615000064 putative effector binding pocket; other site 114615000065 dimerization interface [polypeptide binding]; other site 114615000066 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK05565 114615000067 classical (c) SDRs; Region: SDR_c; cd05233 114615000068 NAD(P) binding site [chemical binding]; other site 114615000069 active site 114615000070 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109 114615000071 Nitroreductase family. Members of this family utilize FMN as a cofactor and catalyze reduction of a variety of nitroaromatic compounds, including nitrofurans, nitrobenzens, nitrophenol, nitrobenzoate and quinones by using either NADH or NADPH as a...; Region: Nitroreductase; cd02136 114615000072 putative FMN binding site [chemical binding]; other site 114615000073 Predicted phosphatases [General function prediction only]; Region: Gph; COG0546 114615000074 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others...; Region: HAD_like; cl11391 114615000075 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others...; Region: HAD_like; cd01427 114615000076 motif II; other site 114615000077 ornithine carbamoyltransferase; Region: orni_carb_tr; TIGR00658 114615000078 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 114615000079 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 114615000080 L-alanine-DL-glutamate epimerase and related enzymes of enolase superfamily [Cell envelope biogenesis, outer membrane / General function prediction only]; Region: COG4948 114615000081 Mandelate racemase (MR)-like subfamily of the enolase superfamily. Enzymes of this subgroup share three conserved carboxylate ligands for the essential divalent metal ion (usually Mg2+), two aspartates and a glutamate, and conserved catalytic residues...; Region: MR_like; cd03316 114615000082 active site pocket [active] 114615000083 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 114615000084 GST_N family, Saccharomyces cerevisiae GTT2-like subfamily; composed of predominantly uncharacterized proteins with similarity to the S. cerevisiae GST protein, GTT2. GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing...; Region: GST_N_GTT2_like; cd03051 114615000085 putative C-terminal domain interface [polypeptide binding]; other site 114615000086 putative GSH binding site (G-site) [chemical binding]; other site 114615000087 putative dimer interface [polypeptide binding]; other site 114615000088 C-terminal, alpha helical domain of the Glutathione S-transferase family; Region: GST_C_family; cl02776 114615000089 N-terminal domain interface [polypeptide binding]; other site 114615000090 dimer interface [polypeptide binding]; other site 114615000091 substrate binding pocket (H-site) [chemical binding]; other site 114615000092 Phytanoyl-CoA dioxygenase (PhyH); Region: PhyH; cl02184 114615000093 Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659 114615000094 Sulfate transporter family; Region: Sulfate_transp; cl00967 114615000095 Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function; Region: STAS_SulP_like_sulfate_transporter; cd07042 114615000096 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 114615000097 ligand binding site [chemical binding]; other site 114615000098 flexible hinge region; other site 114615000099 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 114615000100 Mitochondrial succinate-semialdehyde dehydrogenase and ALDH family members 5A1 and 5F1-like; Region: ALDH_F5_SSADH_GabD; cd07103 114615000101 tetramerization interface [polypeptide binding]; other site 114615000102 NAD(P) binding site [chemical binding]; other site 114615000103 catalytic residues [active] 114615000104 Beta-lactamase; Region: Beta-lactamase; cl01009 114615000105 adenosine kinase; Provisional; Region: PTZ00247 114615000106 Adenosine kinase (AK) catalyzes the phosphorylation of ribofuranosyl-containing nucleoside analogues at the 5'-hydroxyl using ATP or GTP as the phosphate donor.The physiological function of AK is associated with the regulation of extracellular...; Region: adenosine_kinase; cd01168 114615000107 substrate binding site [chemical binding]; other site 114615000108 ATP binding site [chemical binding]; other site 114615000109 Uncharacterized membrane protein, putative virulence factor [General function prediction only]; Region: MviN; COG0728 114615000110 tryptophanyl-tRNA synthetase; Region: trpS; TIGR00233 114615000111 catalytic core domain of tryptophanyl-tRNA synthetase; Region: TrpRS_core; cd00806 114615000112 active site 114615000113 HIGH motif; other site 114615000114 dimer interface [polypeptide binding]; other site 114615000115 KMSKS motif; other site 114615000116 Adenine nucleotide alpha hydrolases superfamily including N type ATP PPases, ATP sulphurylases Universal Stress Response protein and electron transfer flavoprotein (ETF). The domain forms a apha/beta/apha fold which binds to Adenosine nucleotide; Region: AANH_like; cl00292 114615000117 Scaffold protein Nfu/NifU N terminal; Region: Nfu_N; cl07364 114615000118 NifU-like domain; Region: NifU; cl00484 114615000119 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 114615000120 FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202 114615000121 putative active site [active] 114615000122 heme pocket [chemical binding]; other site 114615000123 FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202 114615000124 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 114615000125 putative active site [active] 114615000126 heme pocket [chemical binding]; other site 114615000127 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 114615000128 putative active site [active] 114615000129 heme pocket [chemical binding]; other site 114615000130 Taxis toward Aspartate and Related amino acids and Homologs (TarH). The Tar chemoreceptor of Escherichia coli mediates attractant responses to aspartate, maltose, and phenol, repellent responses to Ni2+ and Co2+, and thermoresponses. These...; Region: TarH; cl00144 114615000131 Inactive homolog of metal-dependent proteases, putative molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: COG1214; cl14000 114615000132 ribosomal-protein-alanine acetyltransferase; Region: rimI; TIGR01575 114615000133 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 114615000134 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 114615000135 metal binding site 2 [ion binding]; metal-binding site 114615000136 putative DNA binding helix; other site 114615000137 metal binding site 1 [ion binding]; metal-binding site 114615000138 dimer interface [polypeptide binding]; other site 114615000139 structural Zn2+ binding site [ion binding]; other site 114615000140 Predicted phosphatases [General function prediction only]; Region: Gph; COG0546 114615000141 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others...; Region: HAD_like; cd01427 114615000142 motif II; other site 114615000143 (dimethylallyl)adenosine tRNA methylthiotransferase; Provisional; Region: PRK14325 114615000144 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 114615000145 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster...; Region: Radical_SAM; cd01335 114615000146 FeS/SAM binding site; other site 114615000147 Phosphate starvation-inducible protein PhoH, predicted ATPase [Signal transduction mechanisms]; Region: PhoH; COG1702 114615000148 PhoH-like protein; Region: PhoH; cl12134 114615000149 Uncharacterized protein family UPF0054; Region: UPF0054; cl00402 114615000150 Putative Mg2+ and Co2+ transporter CorC [Inorganic ion transport and metabolism]; Region: CorC; COG4535 114615000151 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 114615000152 Transporter associated domain; Region: CorC_HlyC; cl08393 114615000153 apolipoprotein N-acyltransferase; Reviewed; Region: lnt; PRK00302 114615000154 Apolipoprotein N-acyl transferase (class 9 nitrilases); Region: ALP_N-acyl_transferase; cd07571 114615000155 putative active site [active] 114615000156 catalytic triad [active] 114615000157 putative dimer interface [polypeptide binding]; other site 114615000158 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 114615000159 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 114615000160 non-specific DNA binding site [nucleotide binding]; other site 114615000161 salt bridge; other site 114615000162 sequence-specific DNA binding site [nucleotide binding]; other site 114615000163 hypothetical protein; Provisional; Region: PRK07338 114615000164 M20 Peptidase Glutamate carboxypeptidase, a periplasmic enzyme; Region: M20_CPDG2; cd03885 114615000165 metal binding site [ion binding]; metal-binding site 114615000166 dimer interface [polypeptide binding]; other site 114615000167 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cl12011 114615000168 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5330 114615000169 Uncharacterized protein conserved in bacteria (DUF2336); Region: DUF2336; pfam10098 114615000170 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG0779 114615000171 The eukaryotic Sm and Sm-like (LSm) proteins associate with RNA to form the core domain of the ribonucleoprotein particles involved in a variety of RNA processing events including pre-mRNA splicing, telomere replication, and mRNA degradation. Members...; Region: Sm_like; cl00259 114615000172 The eukaryotic Sm and Sm-like (LSm) proteins associate with RNA to form the core domain of the ribonucleoprotein particles involved in a variety of RNA processing events including pre-mRNA splicing, telomere replication, and mRNA degradation. Members...; Region: Sm_like; cl00259 114615000173 Sm1 motif; other site 114615000174 RNA binding pocket [nucleotide binding]; other site 114615000175 transcription elongation factor NusA; Validated; Region: nusA; PRK09202 114615000176 NusA N-terminal domain; Region: NusA_N; pfam08529 114615000177 S1_NusA: N-utilizing substance A protein (NusA), S1-like RNA-binding domain. S1-like RNA-binding domains are found in a wide variety of RNA-associated proteins. NusA is a transcription elongation factor containing an N-terminal catalytic domain and...; Region: S1_NusA; cd04455 114615000178 RNA binding site [nucleotide binding]; other site 114615000179 homodimer interface [polypeptide binding]; other site 114615000180 NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134 114615000181 G-X-X-G motif; other site 114615000182 transcription termination factor NusA, C-terminal duplication; Region: nusA_Cterm_rpt; TIGR01954 114615000183 hypothetical protein; Provisional; Region: PRK09190 114615000184 Ylxr homologs; group of conserved hypothetical bacterial proteins of unknown function; structure revealed putative RNA binding cleft; proteins are encoded by an operon that includes other proteins involved in transcription and/or translation; Region: YlxR; cd00279 114615000185 putative RNA binding cleft [nucleotide binding]; other site 114615000186 Bacterial translation initiation factor IF-2 associated region; Region: IF2_assoc; pfam08364 114615000187 translation initiation factor IF-2; Region: IF-2; TIGR00487 114615000188 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 114615000189 IF2/eIF5B (initiation factors 2/ eukaryotic initiation factor 5B) subfamily. IF2/eIF5B contribute to ribosomal subunit joining and function as GTPases that are maximally activated by the presence of both ribosomal subunits. As seen in other GTPases...; Region: IF2_eIF5B; cd01887 114615000190 G1 box; other site 114615000191 putative GEF interaction site [polypeptide binding]; other site 114615000192 GTP/Mg2+ binding site [chemical binding]; other site 114615000193 Switch I region; other site 114615000194 G2 box; other site 114615000195 G3 box; other site 114615000196 Switch II region; other site 114615000197 G4 box; other site 114615000198 G5 box; other site 114615000199 This family represents the domain II of bacterial Initiation Factor 2 (IF2) and its eukaryotic mitochondrial homologue mtIF2. IF2, the largest initiation factor is an essential GTP binding protein. In E. coli three natural forms of IF2 exist in the...; Region: IF2_mtIF2_II; cd03702 114615000200 Translation-initiation factor 2; Region: IF-2; pfam11987 114615000201 mtIF2_IVc: this family represents the C2 subdomain of domain IV of mitochondrial translation initiation factor 2 (mtIF2) which adopts a beta-barrel fold displaying a high degree of structural similarity with domain II of the translation elongation...; Region: mtIF2_IVc; cd03692 114615000202 Ribosome-binding factor A; Region: RBFA; cl00542 114615000203 tRNA pseudouridine synthase B; Provisional; Region: truB; PRK05389 114615000204 PseudoU_synth_EcTruB: Pseudouridine synthase, Escherichia coli TruB like. This group consists of bacterial pseudouridine synthases similar to E. coli TruB and Mycobacterium tuberculosis TruB. Pseudouridine synthases catalyze the isomerization of...; Region: PseudoU_synth_EcTruB; cd02573 114615000205 RNA binding site [nucleotide binding]; other site 114615000206 active site 114615000207 Ribosomal protein S15 (prokaryotic)_S13 (eukaryotic) binds the central domain of 16S rRNA and is required for assembly of the small ribosomal subunit and for intersubunit association, thus representing a key element in the assembly of the whole...; Region: Ribosomal_S15p_S13e; cd00353 114615000208 16S/18S rRNA binding site [nucleotide binding]; other site 114615000209 S13e-L30e interaction site [polypeptide binding]; other site 114615000210 25S rRNA binding site [nucleotide binding]; other site 114615000211 polynucleotide phosphorylase/polyadenylase; Provisional; Region: PRK11824 114615000212 3' exoribonuclease family, domain 1; Region: RNase_PH; pfam01138 114615000213 3' exoribonuclease family, domain 2; Region: RNase_PH_C; pfam03725 114615000214 Polyribonucleotide nucleotidyltransferase, RNA binding domain; Region: PNPase; pfam03726 114615000215 3' exoribonuclease family, domain 1; Region: RNase_PH; pfam01138 114615000216 Polynucleotide phosphorylase (PNPase) K homology RNA-binding domain (KH). PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA in prokaryotes and plant chloroplasts. The C-terminal region of PNPase contains domains homologous to...; Region: PNPase_KH; cd02393 114615000217 putative nucleic acid binding region [nucleotide binding]; other site 114615000218 G-X-X-G motif; other site 114615000219 S1_PNPase: Polynucleotide phosphorylase (PNPase), ), S1-like RNA-binding domain. PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA. It is a trimeric multidomain protein. The C-terminus contains the S1 domain which binds ssRNA...; Region: S1_PNPase; cd04472 114615000220 RNA binding site [nucleotide binding]; other site 114615000221 domain interface; other site 114615000222 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 114615000223 Autotransporter beta-domain; Region: Autotransporter; cl02365 114615000224 enoyl-(acyl carrier protein) reductase; Provisional; Region: PRK06505 114615000225 Enoyl acyl carrier protein (ACP) reductase (ENR), divergent SDR; Region: ENR_SDR; cd05372 114615000226 NAD binding site [chemical binding]; other site 114615000227 homotetramer interface [polypeptide binding]; other site 114615000228 homodimer interface [polypeptide binding]; other site 114615000229 substrate binding site [chemical binding]; other site 114615000230 active site 114615000231 3-oxoacyl-(acyl carrier protein) synthase I; Reviewed; Region: PRK07967 114615000232 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 114615000233 dimer interface [polypeptide binding]; other site 114615000234 active site 114615000235 FabA, beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase: Bacterial protein of the type II, fatty acid synthase system that binds ACP and catalyzes both dehydration and isomerization reactions, apparently in the same active site. The FabA...; Region: FabA; cd01287 114615000236 active site 1 [active] 114615000237 dimer interface [polypeptide binding]; other site 114615000238 active site 2 [active] 114615000239 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 114615000240 metal binding site 2 [ion binding]; metal-binding site 114615000241 putative DNA binding helix; other site 114615000242 metal binding site 1 [ion binding]; metal-binding site 114615000243 dimer interface [polypeptide binding]; other site 114615000244 structural Zn2+ binding site [ion binding]; other site 114615000245 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3807 114615000246 Bacterial SH3 domain; Region: SH3_3; cl02551 114615000247 Bacterial SH3 domain; Region: SH3_3; cl02551 114615000248 Lactate dehydrogenase and related dehydrogenases [Energy production and conversion / Coenzyme metabolism / General function prediction only]; Region: LdhA; COG1052 114615000249 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 114615000250 Transcriptional regulator [Transcription]; Region: LysR; COG0583 114615000251 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 114615000252 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_5; cd08474 114615000253 putative effector binding pocket; other site 114615000254 putative dimerization interface [polypeptide binding]; other site 114615000255 Predicted oxidoreductases (related to aryl-alcohol dehydrogenases) [Energy production and conversion]; Region: Tas; COG0667 114615000256 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and...; Region: Aldo_ket_red; cd06660 114615000257 active site 114615000258 catalytic tetrad [active] 114615000259 molybdopterin biosynthesis protein MoeB; Provisional; Region: PRK05690 114615000260 ThiF_MoeB_HesA. Family of E1-like enzymes involved in molybdopterin and thiamine biosynthesis family. The common reaction mechanism catalyzed by MoeB and ThiF, like other E1 enzymes, begins with a nucleophilic attack of the C-terminal carboxylate of...; Region: ThiF_MoeB_HesA_family; cd00757 114615000261 ATP binding site [chemical binding]; other site 114615000262 substrate interface [chemical binding]; other site 114615000263 His/Ser-rich radical SAM pair-associated protein; Region: His_Ser_Rich; TIGR03979 114615000264 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 114615000265 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following...; Region: ParA; cd02042 114615000266 ParA-like protein; Provisional; Region: PHA02518 114615000267 P-loop; other site 114615000268 Magnesium ion binding site [ion binding]; other site 114615000269 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 114615000270 ligand binding site [chemical binding]; other site 114615000271 formamidopyrimidine/5-formyluracil/ 5-hydroxymethyluracil DNA glycosylase; Validated; Region: PRK01103 114615000272 N-terminal domain of Escherichia coli Fpg1/MutM and related bacterial DNA glycosylases; Region: EcFpg-like_N; cd08966 114615000273 DNA binding site [nucleotide binding] 114615000274 catalytic residue [active] 114615000275 H2TH interface [polypeptide binding]; other site 114615000276 putative catalytic residues [active] 114615000277 turnover-facilitating residue; other site 114615000278 intercalation triad [nucleotide binding]; other site 114615000279 8OG recognition residue [nucleotide binding]; other site 114615000280 putative reading head residues; other site 114615000281 Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831 114615000282 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 114615000283 ubiE/COQ5 methyltransferase family; Region: Ubie_methyltran; pfam01209 114615000284 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cd02440 114615000285 S-adenosylmethionine binding site [chemical binding]; other site 114615000286 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 114615000287 2-polyprenylphenol 6-hydroxylase; Region: UbiB; TIGR01982 114615000288 bifunctional SbtC-like/phosphopantothenoylcysteine decarboxylase/phosphopantothenate synthase; Provisional; Region: PRK13982 114615000289 Plasmid stability protein [General function prediction only]; Region: StbC; COG4691 114615000290 Flavoprotein; Region: Flavoprotein; cl08021 114615000291 DNA / pantothenate metabolism flavoprotein; Region: DFP; cl04410 114615000292 Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557 114615000293 trimer interface [polypeptide binding]; other site 114615000294 active site 114615000295 PAS fold; Region: PAS_7; pfam12860 114615000296 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 114615000297 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via trans-...; Region: HisKA; cl00080 114615000298 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 114615000299 ATP binding site [chemical binding]; other site 114615000300 Mg2+ binding site [ion binding]; other site 114615000301 G-X-G motif; other site 114615000302 Uncharacterised P-loop hydrolase UPF0079; Region: UPF0079; cl00520 114615000303 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 114615000304 Phosphotransferase enzyme family; Region: APH; pfam01636 114615000305 PilZ domain; Region: PilZ; cl01260 114615000306 NTP_transferase_like_1 is a member of the nucleotidyl transferase family; Region: NTP_transferase_like_1; cd06422 114615000307 Substrate binding site [chemical binding]; other site 114615000308 metal binding site [ion binding]; metal-binding site 114615000309 Inactivated superfamily I helicase [DNA replication, recombination, and repair]; Region: COG3893 114615000310 double-strand break repair protein AddB, alphaproteobacterial type; Region: addB_alphas; TIGR02786 114615000311 CRISPR/Cas system-associated protein Cas4; Region: Cas4_I-A_I-B_I-C_I-D_II-B; cl00641 114615000312 double-strand break repair helicase AddA, alphaproteobacterial type; Region: addA_alphas; TIGR02784 114615000313 UvrD/REP helicase; Region: UvrD-helicase; cl14126 114615000314 UvrD/REP helicase; Region: UvrD-helicase; cl14126 114615000315 CRISPR/Cas system-associated protein Cas4; Region: Cas4_I-A_I-B_I-C_I-D_II-B; cl00641 114615000316 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 114615000317 catalytic residues [active] 114615000318 ATP-dependent DNA ligase; Reviewed; Region: ligC; PRK08224 114615000319 Adenylation domain of Mycobacterium tuberculosis LigC-like ATP-dependent DNA ligases; Region: Adenylation_DNA_ligase_LigC; cd07905 114615000320 active site 114615000321 DNA binding site [nucleotide binding] 114615000322 The Oligonucleotide/oligosaccharide binding (OB)-fold domain of ATP-dependent DNA ligase LigC is a DNA-binding module that is part of the catalytic core unit; Region: OBF_DNA_ligase_LigC; cd07970 114615000323 DNA binding site [nucleotide binding] 114615000324 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 114615000325 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 114615000326 active site 114615000327 metal binding site [ion binding]; metal-binding site 114615000328 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 114615000329 Folylpolyglutamate synthase [Coenzyme metabolism]; Region: FolC; COG0285 114615000330 Amidinotransferase; Region: Amidinotransf; cl12043 114615000331 acetyl-CoA carboxylase subunit beta; Validated; Region: PRK05654 114615000332 Acetyl co-enzyme A carboxylase carboxyltransferase alpha subunit; Region: ACCA; cl00513 114615000333 tryptophan synthase; Region: PLN02591 114615000334 Ttryptophan synthase (TRPS) alpha subunit (TSA). TPRS is a bifunctional tetrameric enzyme (2 alpha and 2 beta subunits) that catalyzes the last two steps of L-tryptophan biosynthesis. Alpha and beta subunit catalyze two distinct reactions which are...; Region: Tryptophan_synthase_alpha; cd04724 114615000335 substrate binding site [chemical binding]; other site 114615000336 active site 114615000337 catalytic residues [active] 114615000338 heterodimer interface [polypeptide binding]; other site 114615000339 tryptophan synthase, beta chain; Region: PLN02618 114615000340 Tryptophan synthase-beta: Trptophan synthase is a bifunctional enzyme that catalyses the last two steps in the biosynthesis of L-tryptophan via its alpha and beta reactions. In the alpha reaction, indole 3-glycerol phosphate is cleaved reversibly to...; Region: Trp-synth_B; cd06446 114615000341 pyridoxal 5'-phosphate binding site [chemical binding]; other site 114615000342 catalytic residue [active] 114615000343 Phosphoribosylanthranilate isomerase (PRAI) catalyzes the fourth step of the tryptophan biosynthesis, the conversion of N-(5'- phosphoribosyl)-anthranilate (PRA) to 1-(o-carboxyphenylamino)- 1-deoxyribulose 5-phosphate (CdRP). Most PRAIs are monomeric...; Region: PRAI; cd00405 114615000344 active site 114615000345 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and higher-...; Region: HU_IHF; cd00591 114615000346 IHF dimer interface [polypeptide binding]; other site 114615000347 IHF - DNA interface [nucleotide binding]; other site 114615000348 Signal peptide peptidase A (SppA), a serine protease, has catalytic Ser-Lys dyad; Region: S49_Sppa_N_C; cd07023 114615000349 tandem repeat interface [polypeptide binding]; other site 114615000350 oligomer interface [polypeptide binding]; other site 114615000351 active site residues [active] 114615000352 30S ribosomal protein S1; Reviewed; Region: rpsA; PRK06299 114615000353 S1_RPS1_repeat_ec1_hs1: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec1_hs1; cd05687 114615000354 RNA binding site [nucleotide binding]; other site 114615000355 S1_RPS1_repeat_ec2_hs2: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec2_hs2; cd04465 114615000356 RNA binding site [nucleotide binding]; other site 114615000357 S1_RPS1_repeat_ec3: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists of...; Region: S1_RPS1_repeat_ec3; cd05688 114615000358 RNA binding site [nucleotide binding]; other site 114615000359 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain...; Region: S1_like; cl09927 114615000360 RNA binding site [nucleotide binding]; other site 114615000361 S1_RPS1_repeat_ec5: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists of...; Region: S1_RPS1_repeat_ec5; cd05690 114615000362 RNA binding site [nucleotide binding]; other site 114615000363 S1_RPS1_repeat_ec6: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists of...; Region: S1_RPS1_repeat_ec6; cd05691 114615000364 RNA binding site [nucleotide binding]; other site 114615000365 cytidylate kinase; Provisional; Region: cmk; PRK00023 114615000366 Cytidine monophosphate kinase (CMPK) catalyzes the reversible phosphorylation of cytidine monophosphate (CMP) to produce cytidine diphosphate (CDP), using ATP as the preferred phosphoryl donor; Region: CMPK; cd02020 114615000367 CMP-binding site; other site 114615000368 The sites determining sugar specificity; other site 114615000369 3-phosphoshikimate 1-carboxyvinyltransferase; Provisional; Region: PRK02427 114615000370 EPSP synthase domain. 3-phosphoshikimate 1-carboxyvinyltransferase (5-enolpyruvylshikimate-3-phosphate synthase) (EC 2.5.1.19) catalyses the reaction between shikimate-3-phosphate (S3P) and phosphoenolpyruvate (PEP) to form 5-enolpyruvylshkimate-3-...; Region: EPSP_synthase; cd01556 114615000371 hinge; other site 114615000372 active site 114615000373 Protein of unknown function (FYDLN_acid); Region: FYDLN_acid; pfam09538 114615000374 Catalytic GIY-YIG domain of yeast structure-specific endonuclease subunit SLX1 and its homologs; Region: GIY-YIG_SLX1_like; cd10449 114615000375 GIY-YIG motif/motif A; other site 114615000376 putative active site [active] 114615000377 putative metal binding site [ion binding]; other site 114615000378 Transcriptional regulators [Transcription]; Region: MarR; COG1846 114615000379 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 114615000380 OsmC-like protein; Region: OsmC; cl00767 114615000381 CoA-transferase family III; Region: CoA_transf_3; cl00778 114615000382 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 114615000383 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 114615000384 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cl00427 114615000385 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 114615000386 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261 114615000387 dimer interface [polypeptide binding]; other site 114615000388 conserved gate region; other site 114615000389 putative PBP binding loops; other site 114615000390 ABC-ATPase subunit interface; other site 114615000391 glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650 114615000392 The N-terminal ATPase domain of the maltose transporter, MalK. ATP binding cassette (ABC) proteins function from bacteria to human, mediating the translocation of substances into and out of cells or organelles. ABC transporters contain two...; Region: ABC_MalK_N; cd03301 114615000393 Walker A/P-loop; other site 114615000394 ATP binding site [chemical binding]; other site 114615000395 Q-loop/lid; other site 114615000396 ABC transporter signature motif; other site 114615000397 Walker B; other site 114615000398 D-loop; other site 114615000399 H-loop/switch region; other site 114615000400 Alpha-crystallin domain (ACD) found in Escherichia coli inclusion body-associated proteins IbpA and IbpB, and similar proteins. IbpA and IbpB are 16 kDa small heat shock proteins (sHsps). sHsps are molecular chaperones that suppress protein...; Region: ACD_IbpA-B_like; cd06470 114615000401 putative dimer interface [polypeptide binding]; other site 114615000402 Protein of unknown function (DUF1150); Region: DUF1150; cl11577 114615000403 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 114615000404 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 114615000405 active site 114615000406 phosphorylation site [posttranslational modification] 114615000407 RaiA ('ribosome-associated inhibitor A', also known as Protein Y (PY), YfiA, and SpotY, is a stress-response protein that binds the ribosomal subunit interface and arrests translation by interfering with aminoacyl-tRNA binding to the ribosomal A site...; Region: RaiA; cd00552 114615000408 30S subunit binding site; other site 114615000409 RNA polymerase factor sigma-54; Provisional; Region: PRK12469 114615000410 Sigma-54 factor, Activator interacting domain (AID); Region: Sigma54_AID; pfam00309 114615000411 Sigma-54 factor, core binding domain; Region: Sigma54_CBD; pfam04963 114615000412 Sigma-54, DNA binding domain; Region: Sigma54_DBD; pfam04552 114615000413 ABC-type (unclassified) transport system, ATPase component [General function prediction only]; Region: YhbG; COG1137 114615000414 The ABC transporters belonging to the YhbG family are similar to members of the Mj1267_LivG family, which is involved in the transport of branched-chain amino acids. The genes yhbG and yhbN are located in a single operon and may function together in...; Region: ABC_YhbG; cd03218 114615000415 Walker A/P-loop; other site 114615000416 ATP binding site [chemical binding]; other site 114615000417 Q-loop/lid; other site 114615000418 ABC transporter signature motif; other site 114615000419 Walker B; other site 114615000420 D-loop; other site 114615000421 H-loop/switch region; other site 114615000422 OstA-like protein; Region: OstA; cl00844 114615000423 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5375 114615000424 DEDDy 3'-5' exonuclease domain of Ribonuclease D and similar proteins; Region: RNaseD_exo; cd06142 114615000425 putative active site [active] 114615000426 catalytic site [active] 114615000427 putative substrate binding site [chemical binding]; other site 114615000428 Bacterial extracellular solute-binding protein, family 7; Region: SBP_bac_7; cl00710 114615000429 Tripartite ATP-independent periplasmic transporters, DctQ component; Region: DctQ; cl01181 114615000430 DctM-like transporters; Region: DctM; pfam06808 114615000431 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl09110 114615000432 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and...; Region: PBPb; cd00134 114615000433 Bacterial periplasmic substrate-binding proteins; Region: PBPb; smart00062 114615000434 substrate binding pocket [chemical binding]; other site 114615000435 membrane-bound complex binding site; other site 114615000436 hinge residues; other site 114615000437 cytochrome c oxidase, cbb3-type, subunit III; Region: ccoP; TIGR00782 114615000438 Dehydrogenases with pyrrolo-quinoline quinone (PQQ) as cofactor, like ethanol, methanol, and membrane bound glucose dehydrogenases. The alignment model contains an 8-bladed beta-propeller; Region: PQQ_DH; cl11493 114615000439 PQQ-dependent dehydrogenase, methanol/ethanol family; Region: PQQ_enz_alc_DH; TIGR03075 114615000440 Trp docking motif; other site 114615000441 'Velcro' closure; other site 114615000442 active site 114615000443 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084 114615000444 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 114615000445 Predicted nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG0702 114615000446 NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, subunit 9, 39 kDa, (NDUFA9) -like, atypical (a) SDRs; Region: NDUFA9_like_SDR_a; cd05271 114615000447 putative NAD(P) binding site [chemical binding]; other site 114615000448 active site 114615000449 Bacitracin resistance protein BacA; Region: BacA; cl00858 114615000450 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 114615000451 Glutathione S-transferase (GST) family, N-terminal domain; a large, diverse group of cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of endogenous and xenobiotic...; Region: GST_N_family; cd00570 114615000452 C-terminal domain interface [polypeptide binding]; other site 114615000453 GSH binding site (G-site) [chemical binding]; other site 114615000454 dimer interface [polypeptide binding]; other site 114615000455 C-terminal, alpha helical domain of the Glutathione S-transferase family; Region: GST_C_family; cl02776 114615000456 N-terminal domain interface [polypeptide binding]; other site 114615000457 dimer interface [polypeptide binding]; other site 114615000458 substrate binding pocket (H-site) [chemical binding]; other site 114615000459 Uncharacterized Fe-S protein [Energy production and conversion]; Region: COG1600 114615000460 Domain of unknown function (DUF1730); Region: DUF1730; pfam08331 114615000461 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 114615000462 translation initiation factor IF-3; Reviewed; Region: infC; PRK00028 114615000463 Translation initiation factor IF-3, N-terminal domain; Region: IF3_N; pfam05198 114615000464 Translation initiation factor IF-3, C-terminal domain; Region: IF3_C; pfam00707 114615000465 Ribosomal protein L35; Region: Ribosomal_L35p; cl00392 114615000466 Ribosomal protein L20; Region: Ribosomal_L20; cd07026 114615000467 23S rRNA binding site [nucleotide binding]; other site 114615000468 L21 binding site [polypeptide binding]; other site 114615000469 L13 binding site [polypeptide binding]; other site 114615000470 phenylalanyl-tRNA synthetase subunit alpha; Validated; Region: pheS; PRK00488 114615000471 Aminoacyl tRNA synthetase class II, N-terminal domain; Region: Phe_tRNA-synt_N; pfam02912 114615000472 Phenylalanyl-tRNA synthetase (PheRS) alpha chain catalytic core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs. This domain is primarily responsible...; Region: PheRS_alpha_core; cd00496 114615000473 dimer interface [polypeptide binding]; other site 114615000474 motif 1; other site 114615000475 active site 114615000476 motif 2; other site 114615000477 motif 3; other site 114615000478 ASC-1 homology domain, subfamily similar to Enterococcus faecalis Ef3133. The ASCH domain, a small beta-barrel domain found in all three kingdoms of life, resembles the RNA-binding PUA domain and may also interact with RNA. ASCH has been proposed to...; Region: ASCH_Ef3133_like; cd06553 114615000479 phenylalanyl-tRNA synthetase subunit beta; Reviewed; Region: pheT; PRK00629 114615000480 tRNA-binding-domain-containing prokaryotic phenylalanly tRNA synthetase (PheRS) beta chain. PheRS aminoacylate phenylalanine transfer RNAs (tRNAphe). PheRSs belong structurally to class II aminoacyl tRNA synthetases (aaRSs) but, as they aminoacylate...; Region: tRNA_bind_bactPheRS; cd02796 114615000481 putative tRNA-binding site [nucleotide binding]; other site 114615000482 B3/4 domain; Region: B3_4; cl11458 114615000483 tRNA synthetase B5 domain; Region: B5; cl08394 114615000484 Phenylalanyl-tRNA synthetase (PheRS) beta chain core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure. While class II aaRSs generally aminoacylate the 3'-OH ribose of the appropriate tRNA, PheRS is an...; Region: PheRS_beta_core; cd00769 114615000485 dimer interface [polypeptide binding]; other site 114615000486 motif 1; other site 114615000487 motif 3; other site 114615000488 motif 2; other site 114615000489 Ferredoxin-fold anticodon binding domain; Region: FDX-ACB; cl08386 114615000490 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 114615000491 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 114615000492 Flavin containing amine oxidoreductase; Region: Amino_oxidase; pfam01593 114615000493 Orthopoxvirus protein of unknown function (DUF830); Region: DUF830; cl13998 114615000494 Transcriptional regulators CsoR (copper-sensitive operon repressor), RcnR, and FrmR, and related domains; this domain superfamily was previously known as DUF156; Region: CsoR-like_DUF156; cd10148 114615000495 putative homotetramer interface [polypeptide binding]; other site 114615000496 putative homodimer interface [polypeptide binding]; other site 114615000497 putative allosteric switch controlling residues; other site 114615000498 putative metal binding site [ion binding]; other site 114615000499 putative homodimer-homodimer interface [polypeptide binding]; other site 114615000500 Ribosomal protein L24e/L24 is a ribosomal protein found in eukaryotes (L24) and in archaea (L24e, distinct from archaeal L24). L24e/L24 is located on the surface of the large subunit, adjacent to proteins L14 and L3, and near the translation factor...; Region: Ribosomal_L24e_L24; cl00909 114615000501 Ribosomal protein L24e/L24 is a ribosomal protein found in eukaryotes (L24) and in archaea (L24e, distinct from archaeal L24). L24e/L24 is located on the surface of the large subunit, adjacent to proteins L14 and L3, and near the translation factor...; Region: Ribosomal_L24e_L24; cl00909 114615000502 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 114615000503 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 114615000504 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others...; Region: HAD_like; cl11391 114615000505 Etoposide-induced protein 2.4 (EI24); Region: EI24; cl01126 114615000506 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 114615000507 putative substrate translocation pore; other site 114615000508 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 114615000509 Isoprenylcysteine carboxyl methyltransferase (ICMT) family; Region: ICMT; cl00763 114615000510 Predicted naringenin-chalcone synthase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: BcsA; COG3424 114615000511 Chalcone and stilbene synthases; plant-specific polyketide synthases (PKS) and related enzymes, also called type III PKSs. PKS generate an array of different products, dependent on the nature of the starter molecule. They share a common chemical...; Region: CHS_like; cd00831 114615000512 malonyl-CoA binding site [chemical binding]; other site 114615000513 dimer interface [polypeptide binding]; other site 114615000514 active site 114615000515 product binding site; other site 114615000516 Predicted EndoIII-related endonuclease [DNA replication, recombination, and repair]; Region: Nth; COG0177 114615000517 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 114615000518 minor groove reading motif; other site 114615000519 helix-hairpin-helix signature motif; other site 114615000520 substrate binding pocket [chemical binding]; other site 114615000521 active site 114615000522 Iron-sulfur binding domain of endonuclease III; Region: EndIII_4Fe-2S; cl15304 114615000523 Integral membrane protein (DUF2244); Region: DUF2244; cl02302 114615000524 bifunctional DNA-binding transcriptional dual regulator/O6-methylguanine-DNA methyltransferase; Provisional; Region: PRK15435 114615000525 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 114615000526 DNA binding site [nucleotide binding] 114615000527 active site 114615000528 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 114615000529 Histidine phosphatase superfamily (branch 1); Region: His_Phos_1; pfam00300 114615000530 catalytic core [active] 114615000531 dihydrodipicolinate reductase; Provisional; Region: PRK00048 114615000532 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 114615000533 Dihydrodipicolinate reductase, C-terminus; Region: DapB_C; pfam05173 114615000534 Protein of unknown function (DUF1330); Region: DUF1330; cl02288 114615000535 Orotidine 5'-phosphate decarboxylase (ODCase) is a dimeric enzyme that decarboxylates orotidine 5'-monophosphate (OMP) to form uridine 5'-phosphate (UMP), an essential step in the pyrimidine biosynthetic pathway. In mammals, UMP synthase contains two...; Region: OMP_decarboxylase_like; cd04725 114615000536 active site 114615000537 dimer interface [polypeptide binding]; other site 114615000538 NADPH-dependent FMN reductase; Region: FMN_red; cl00438 114615000539 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cl12011 114615000540 chaperone protein DnaJ; Provisional; Region: PRK10767 114615000541 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of...; Region: DnaJ; cd06257 114615000542 HSP70 interaction site [polypeptide binding]; other site 114615000543 DnaJ central domain; Region: DnaJ_CXXCXGXG; cl14908 114615000544 DnaJ C terminal domain; Region: DnaJ_C; pfam01556 114615000545 molecular chaperone DnaK; Provisional; Region: dnaK; PRK00290 114615000546 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cd02440 114615000547 S-adenosylmethionine binding site [chemical binding]; other site 114615000548 undecaprenyl phosphate 4-deoxy-4-formamido-L-arabinose transferase; Provisional; Region: PRK10714 114615000549 Bacterial DPM1_like enzymes are related to eukaryotic DPM1; Region: DPM1_like_bac; cd04187 114615000550 Ligand binding site [chemical binding]; other site 114615000551 Putative Catalytic site [active] 114615000552 DXD motif; other site 114615000553 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cd02440 114615000554 S-adenosylmethionine binding site [chemical binding]; other site 114615000555 Molecular chaperone GrpE (heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: GrpE; COG0576 114615000556 GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70)-type ATPases. The GrpE dimer binds to the ATPase domain of Hsp70 catalyzing the dissociation of ADP, which enables rebinding of ATP, one step in the Hsp70 reaction cycle in protein folding...; Region: GrpE; cd00446 114615000557 dimer interface [polypeptide binding]; other site 114615000558 hsp70 (ATPase domain) interactions [polypeptide binding]; other site 114615000559 heat-inducible transcription repressor; Provisional; Region: hrcA; PRK00082 114615000560 HrcA protein C terminal domain; Region: HrcA; pfam01628 114615000561 ribonuclease PH; Reviewed; Region: rph; PRK00173 114615000562 3' exoribonuclease family, domain 1; Region: RNase_PH; pfam01138 114615000563 3' exoribonuclease family, domain 2; Region: RNase_PH_C; pfam03725 114615000564 NTPase/HAM1. This family consists of the HAM1 protein and pyrophosphate-releasing xanthosine/ inosine triphosphatase. HAM1 protects the cell against mutagenesis by the base analog 6-N-hydroxylaminopurine (HAP) in E. Coli and S. cerevisiae. A Ham1-...; Region: HAM1; cd00515 114615000565 active site 114615000566 dimerization interface [polypeptide binding]; other site 114615000567 coproporphyrinogen III oxidase; Provisional; Region: PRK09057 114615000568 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster...; Region: Radical_SAM; cl15259 114615000569 HemN C-terminal region; Region: HemN_C; pfam06969 114615000570 Periplasmic binding component of lipoprotein LppC, an immunodominant antigen; Region: PBP1_YraM_LppC_lipoprotein_like; cd06339 114615000571 putative ligand binding site [chemical binding]; other site 114615000572 Tetrapyrrole (Corrin/Porphyrin) Methylases; Region: TP_methylase; cl00304 114615000573 Predicted methyltransferases [General function prediction only]; Region: COG0313 114615000574 Uncharacterised protein family UPF0102; Region: UPF0102; cl00516 114615000575 glutathione synthetase; Provisional; Region: PRK05246 114615000576 Prokaryotic glutathione synthetase, N-terminal domain; Region: GSH-S_N; pfam02951 114615000577 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; cl03087 114615000578 Escherichia coli exonuclease III (ExoIII) and Neisseria meningitides NExo-like subfamily of the ExoIII family purinic/apyrimidinic (AP) endonucleases; Region: ExoIII-like_AP-endo; cd09086 114615000579 putative phosphate binding site [ion binding]; other site 114615000580 putative catalytic site [active] 114615000581 active site 114615000582 metal binding site A [ion binding]; metal-binding site 114615000583 DNA binding site [nucleotide binding] 114615000584 putative AP binding site [nucleotide binding]; other site 114615000585 putative metal binding site B [ion binding]; other site 114615000586 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 114615000587 ligand binding site [chemical binding]; other site 114615000588 flexible hinge region; other site 114615000589 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 114615000590 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156 114615000591 active site 114615000592 phosphorylation site [posttranslational modification] 114615000593 intermolecular recognition site; other site 114615000594 dimerization interface [polypeptide binding]; other site 114615000595 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase...; Region: trans_reg_C; cd00383 114615000596 DNA binding site [nucleotide binding] 114615000597 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3786 114615000598 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; cl11421 114615000599 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes, YBL036c-like proteins; Region: PLPDE_III_YBL036c_like; cd00635 114615000600 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 114615000601 catalytic residue [active] 114615000602 Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices connected by an extended linker. The...; Region: HAMP; cl01054 114615000603 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 114615000604 metal binding site [ion binding]; metal-binding site 114615000605 active site 114615000606 I-site; other site 114615000607 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 114615000608 metal binding site [ion binding]; metal-binding site 114615000609 active site 114615000610 I-site; other site 114615000611 leucyl-tRNA synthetase; Validated; Region: leuS; PRK00390 114615000612 catalytic core domain of leucyl-tRNA synthetases; Region: LeuRS_core; cd00812 114615000613 HIGH motif; other site 114615000614 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 114615000615 active site 114615000616 KMSKS motif; other site 114615000617 Anticodon-binding domain of bacterial and eukaryotic mitochondrial leucyl tRNA synthetases; Region: Anticodon_Ia_Leu_BEm; cd07958 114615000618 tRNA binding surface [nucleotide binding]; other site 114615000619 Predicted secreted (periplasmic) protein (DUF2159); Region: DUF2159; cl11572 114615000620 DNA polymerase III subunit delta; Reviewed; Region: holA; PRK06585 114615000621 DNA polymerase III, delta subunit; Region: DNA_pol3_delta; pfam06144 114615000622 ParB-like partition proteins; Region: parB_part; TIGR00180 114615000623 ParB-like nuclease domain; Region: ParBc; cl02129 114615000624 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 114615000625 Ras-like GTPase superfamily. The Ras-like superfamily of small GTPases consists of several families with an extremely high degree of structural and functional similarity. The Ras superfamily is divided into at least four families in eukaryotes: the Ras...; Region: Ras_like_GTPase; cl10444 114615000626 16S rRNA methyltransferase GidB; Reviewed; Region: gidB; PRK00107 114615000627 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 114615000628 Flavin-dependent tRNA uridine 5-carboxymethylaminomethyl modification enzyme GidA [Cell cycle control, cell division, chromosome partitioning]; Region: GidA; COG0445 114615000629 tRNA modification GTPase TrmE; Reviewed; Region: trmE; PRK05291 114615000630 GTP-binding protein TrmE N-terminus; Region: TrmE_N; pfam10396 114615000631 TrmE (MnmE, ThdF, MSS1) is a 3-domain protein found in bacteria and eukaryotes. It controls modification of the uridine at the wobble position (U34) of tRNAs that read codons ending with A or G in the mixed codon family boxes. TrmE contains a GTPase...; Region: trmE; cd04164 114615000632 G1 box; other site 114615000633 GTP/Mg2+ binding site [chemical binding]; other site 114615000634 Switch I region; other site 114615000635 G2 box; other site 114615000636 Switch II region; other site 114615000637 G3 box; other site 114615000638 G4 box; other site 114615000639 G5 box; other site 114615000640 Catalytic cysteine-containing C-terminus of GTPase, MnmE; Region: GTPase_Cys_C; pfam12631 114615000641 transcription termination factor Rho; Provisional; Region: rho; PRK09376 114615000642 Rho termination factor, N-terminal domain; Region: Rho_N; cl06505 114615000643 Rho_CSD: Rho protein cold-shock domain (CSD). Rho protein is a transcription termination factor in most bacteria. In bacteria, there are two distinct mechanisms for mRNA transcription termination. In intrinsic termination, RNA polymerase and nascent...; Region: Rho_CSD; cd04459 114615000644 RNA binding site [nucleotide binding]; other site 114615000645 Transcription termination factor rho is a bacterial ATP-dependent RNA/DNA helicase. It is a homohexamer. Each monomer consists of an N-terminal domain of the OB fold, which is responsible for binding to cysteine rich nucleotides. This alignment is of...; Region: rho_factor; cd01128 114615000646 multimer interface [polypeptide binding]; other site 114615000647 Walker A motif; other site 114615000648 ATP binding site [chemical binding]; other site 114615000649 Walker B motif; other site 114615000650 Uncharacterised protein family (UPF0093); Region: UPF0093; cl00863 114615000651 Domain of unknown function (DUF299); Region: DUF299; cl00780 114615000652 Nucleotide binding protein Maf. Maf has been implicated in inhibition of septum formation in eukaryotes, bacteria and archaea, but homologs in B.subtilis and S.cerevisiae are nonessential for cell division. Maf has been predicted to be a nucleotide- or...; Region: Maf; cd00555 114615000653 active site 114615000654 dimer interface [polypeptide binding]; other site 114615000655 Dephospho-CoA kinase [Coenzyme metabolism]; Region: CoaE; COG0237 114615000656 Dephospho-coenzyme A kinase (DPCK, EC 2.7.1.24) catalyzes the phosphorylation of dephosphocoenzyme A (dCoA) to yield CoA, which is the final step in CoA biosynthesis; Region: DPCK; cd02022 114615000657 CoA-binding site [chemical binding]; other site 114615000658 ATP-binding [chemical binding]; other site 114615000659 Proteobacterial; Region: dnaQ_proteo; TIGR01406 114615000660 DEDDh 3'-5' exonuclease domain of the epsilon subunit of Escherichia coli DNA polymerase III and similar proteins; Region: DNA_pol_III_epsilon_Ecoli_like; cd06131 114615000661 active site 114615000662 substrate binding site [chemical binding]; other site 114615000663 catalytic site [active] 114615000664 Preprotein translocase subunit SecB. SecB is a cytoplasmic component of the multisubunit membrane-bound enzyme termed Sec protein translocase, which is the main constituent of the General Secretory (type II) Pathway involved in translocation of nascent...; Region: Translocase_SecB; cl00251 114615000665 SecA binding site; other site 114615000666 Preprotein binding site; other site 114615000667 Tim44-like domain; Region: Tim44; cl09208 114615000668 Membrane-bound lytic murein transglycosylase [Cell envelope biogenesis, outer membrane]; Region: MltA; COG2821 114615000669 MltA specific insert domain; Region: MltA; cl08398 114615000670 3D domain; Region: 3D; cl01439 114615000671 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2840 114615000672 Smr domain; Region: Smr; cl02619 114615000673 ATP-dependent protease ATP-binding subunit HslU; Provisional; Region: hslU; PRK05201 114615000674 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes...; Region: AAA; cd00009 114615000675 Walker A motif; other site 114615000676 ATP binding site [chemical binding]; other site 114615000677 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 114615000678 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; cl11083 114615000679 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 114615000680 Siderophore biosynthesis protein domain; Region: AlcB; cl11000 114615000681 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 114615000682 Protein of unknown function (DUF2585); Region: DUF2585; cl07906 114615000683 Protease HslV and the ATPase/chaperone HslU are part of an ATP-dependent proteolytic system that is the prokaryotic homolog of the proteasome. HslV is a dimer of hexamers (a dodecamer) that forms a central proteolytic chamber with active sites on the...; Region: protease_HslV; cd01913 114615000684 active site 114615000685 HslU subunit interaction site [polypeptide binding]; other site 114615000686 Imidazoleglycerol-phosphate dehydratase; Region: IGPD; cd07914 114615000687 putative active site pocket [active] 114615000688 4-fold oligomerization interface [polypeptide binding]; other site 114615000689 metal binding residues [ion binding]; metal-binding site 114615000690 3-fold/trimer interface [polypeptide binding]; other site 114615000691 Protein of unknown function (DUF2628); Region: DUF2628; pfam10947 114615000692 imidazole glycerol phosphate synthase subunit HisH; Provisional; Region: hisH; PRK13146 114615000693 Type 1 glutamine amidotransferase (GATase1) domain found in imidazole glycerol phosphate synthase (IGPS); Region: GATase1_IGP_Synthase; cd01748 114615000694 putative active site [active] 114615000695 oxyanion strand; other site 114615000696 catalytic triad [active] 114615000697 Phosphoribosylformimino-5-aminoimidazole carboxamide ribonucleotide (ProFAR) isomerase [Amino acid transport and metabolism]; Region: HisA; COG0106 114615000698 HisA. Phosphoribosylformimino-5-aminoimidazole carboxamide ribonucleotide (ProFAR) isomerase catalyzes the fourth step in histidine biosynthesis, an isomerisation of the aminoaldose moiety of ProFAR to the aminoketose of PRFAR (N-(5'-phospho-D-1'-...; Region: HisA; cd04732 114615000699 catalytic residues [active] 114615000700 Imidazoleglycerol-phosphate synthase [Amino acid transport and metabolism]; Region: HisF; COG0107 114615000701 The cyclase subunit of imidazoleglycerol phosphate synthase (HisF). Imidazole glycerol phosphate synthase (IGPS) catalyzes the fifth step of histidine biosynthesis, the formation of the imidazole ring. IGPS converts N1-(5'-phosphoribulosyl)-formimino-5-; Region: HisF; cd04731 114615000702 substrate binding site [chemical binding]; other site 114615000703 glutamase interaction surface [polypeptide binding]; other site 114615000704 MazG nucleotide pyrophosphohydrolase domain; Region: MazG; cl00345 114615000705 pantothenate kinase; Provisional; Region: PRK05439 114615000706 Pantothenate kinase (PanK) catalyzes the phosphorylation of pantothenic acid to form 4'-phosphopantothenic, which is the first of five steps in coenzyme A (CoA) biosynthetic pathway. The reaction carried out by this enzyme is a key regulatory point in...; Region: PanK; cd02025 114615000707 ATP-binding site [chemical binding]; other site 114615000708 CoA-binding site [chemical binding]; other site 114615000709 Mg2+-binding site [ion binding]; other site 114615000710 PAS domain S-box; Region: sensory_box; TIGR00229 114615000711 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459 114615000712 TMAO reductase sytem sensor TorS; Region: TMAO_torS; TIGR02956 114615000713 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via trans-...; Region: HisKA; cl00080 114615000714 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 114615000715 ATP binding site [chemical binding]; other site 114615000716 Mg2+ binding site [ion binding]; other site 114615000717 G-X-G motif; other site 114615000718 Response regulator receiver domain; Region: Response_reg; pfam00072 114615000719 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156 114615000720 active site 114615000721 phosphorylation site [posttranslational modification] 114615000722 intermolecular recognition site; other site 114615000723 dimerization interface [polypeptide binding]; other site 114615000724 Predicted ATPase with chaperone activity [Posttranslational modification, protein turnover, chaperones]; Region: COG0606 114615000725 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 114615000726 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5330 114615000727 Uncharacterized protein conserved in bacteria (DUF2336); Region: DUF2336; pfam10098 114615000728 Outer membrane lipoprotein carrier protein LolA; Region: LolA; cl01065 114615000729 DNA translocase FtsK; Provisional; Region: PRK10263 114615000730 PUCC protein; Region: PUCC; pfam03209 114615000731 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 114615000732 Ftsk gamma domain; Region: Ftsk_gamma; cl09645 114615000733 aspartate aminotransferase; Provisional; Region: PRK08361 114615000734 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 114615000735 pyridoxal 5'-phosphate binding site [chemical binding]; other site 114615000736 homodimer interface [polypeptide binding]; other site 114615000737 catalytic residue [active] 114615000738 outer membrane protein assembly complex, YaeT protein; Region: OM_YaeT; TIGR03303 114615000739 Surface antigen variable number repeat; Region: Surf_Ag_VNR; cl10520 114615000740 Surface antigen variable number repeat; Region: Surf_Ag_VNR; cl10520 114615000741 Surface antigen variable number repeat; Region: Surf_Ag_VNR; cl10520 114615000742 Surface antigen variable number repeat; Region: Surf_Ag_VNR; cl10520 114615000743 Surface antigen; Region: Bac_surface_Ag; cl03097 114615000744 classical (c) SDRs; Region: SDR_c; cd05233 114615000745 NAD(P) binding site [chemical binding]; other site 114615000746 active site 114615000747 malonyl-CoA synthase; Validated; Region: PRK07514 114615000748 Acyl-protein synthetase, LuxE; Region: LuxE; cl10450 114615000749 Succinate:quinone oxidoreductase (SQR) Type C subfamily, Succinate dehydrogenase C (SdhC) subunit; composed of bacterial SdhC and eukaryotic large cytochrome b binding (CybL) proteins. SQR catalyzes the oxidation of succinate to fumarate coupled to the...; Region: SQR_TypeC_SdhC; cd03499 114615000750 Iron-sulfur protein interface; other site 114615000751 proximal quinone binding site [chemical binding]; other site 114615000752 SdhD (CybS) interface [polypeptide binding]; other site 114615000753 proximal heme binding site [chemical binding]; other site 114615000754 Succinate:quinone oxidoreductase (SQR) Type C subfamily, Succinate dehydrogenase D (SdhD) subunit-like; composed of predominantly uncharacterized bacterial proteins with similarity to the E. coli SdhD subunit. One characterized protein is the...; Region: SQR_TypeC_SdhD_like; cd03495 114615000755 putative SdhC subunit interface [polypeptide binding]; other site 114615000756 putative proximal heme binding site [chemical binding]; other site 114615000757 putative Iron-sulfur protein interface [polypeptide binding]; other site 114615000758 putative proximal quinone binding site; other site 114615000759 succinate dehydrogenase flavoprotein subunit; Reviewed; Region: sdhA; PRK09078 114615000760 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 114615000761 domain; Region: Succ_DH_flav_C; pfam02910 114615000762 succinate dehydrogenase iron-sulfur subunit; Reviewed; Region: sdhB; PRK05950 114615000763 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via trans-...; Region: HisKA; cd00082 114615000764 dimer interface [polypeptide binding]; other site 114615000765 phosphorylation site [posttranslational modification] 114615000766 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 114615000767 ATP binding site [chemical binding]; other site 114615000768 Mg2+ binding site [ion binding]; other site 114615000769 G-X-G motif; other site 114615000770 Response regulator receiver domain; Region: Response_reg; pfam00072 114615000771 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156 114615000772 active site 114615000773 phosphorylation site [posttranslational modification] 114615000774 intermolecular recognition site; other site 114615000775 dimerization interface [polypeptide binding]; other site 114615000776 ABC-type uncharacterized transport system, permease and ATPase components [General function prediction only]; Region: COG4178 114615000777 ABC transporter transmembrane region; Region: ABC_membrane; cl00549 114615000778 Peroxisomal ATP-binding cassette transporter (Pat) is involved in the import of very long-chain fatty acids (VLCFA) into the peroxisome. The peroxisomal membrane forms a permeability barrier for a wide variety of metabolites required for and formed...; Region: ABCD_peroxisomal_ALDP; cd03223 114615000779 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cl12011 114615000780 Uncharacterized stress protein (general stress protein 26) [General function prediction only]; Region: COG3871 114615000781 Pyridoxine 5'-phosphate (PNP) oxidase-like proteins; Region: PNPOx_like; cl00381 114615000782 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 114615000783 ligand binding site [chemical binding]; other site 114615000784 argininosuccinate synthase; Region: argG; TIGR00032 114615000785 Argininosuccinate synthase. The Argininosuccinate synthase is a urea cycle enzyme that catalyzes the penultimate step in arginine biosynthesis: the ATP-dependent ligation of citrulline to aspartate to form argininosuccinate, AMP and pyrophosphate . In...; Region: Argininosuccinate_Synthase; cd01999 114615000786 ANP binding site [chemical binding]; other site 114615000787 Substrate Binding Site II [chemical binding]; other site 114615000788 Substrate Binding Site I [chemical binding]; other site 114615000789 PAP2_like_6 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which mainly contains bacterial proteins, lacks functional characterization and may act as a membrane-associated lipid phosphatase; Region: PAP2_like_6; cd03396 114615000790 active site 114615000791 Predicted Fe-S-cluster redox enzyme [General function prediction only]; Region: COG0820 114615000792 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster...; Region: Radical_SAM; cd01335 114615000793 FeS/SAM binding site; other site 114615000794 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 114615000795 Quinone oxidoreductase (QOR); Region: QOR1; cd08241 114615000796 NAD(P) binding site [chemical binding]; other site 114615000797 TRAP-type uncharacterized transport system, periplasmic component [General function prediction only]; Region: Imp; COG2358 114615000798 Tripartite tricarboxylate transporter family receptor; Region: TctC; cl15260 114615000799 Protein of unknown function (DUF1232); Region: DUF1232; cl01318 114615000800 PCD_DCoH: The bifunctional protein pterin-4alpha-carbinolamine dehydratase (PCD), also known as DCoH (dimerization cofactor of hepatocyte nuclear factor-1), is both a transcription activator and a metabolic enzyme. DCoH stimulates gene expression by...; Region: PCD_DCoH_subfamily_b; cd00914 114615000801 aromatic arch; other site 114615000802 DCoH dimer interaction site [polypeptide binding]; other site 114615000803 DCoH /HNF-1 dimer interaction site [polypeptide binding]; other site 114615000804 DCoH tetramer interaction site [polypeptide binding]; other site 114615000805 substrate binding site [chemical binding]; other site 114615000806 Tripartite tricarboxylate transporter family receptor; Region: TctC; cl15260 114615000807 Phosphodiesterase/alkaline phosphatase D [Inorganic ion transport and metabolism]; Region: PhoD; COG3540 114615000808 Bacillus subtilis PhoD and related proteins, metallophosphatase domain; Region: MPP_PhoD; cd07389 114615000809 putative active site [active] 114615000810 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 114615000811 Response regulator receiver domain; Region: Response_reg; pfam00072 114615000812 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156 114615000813 active site 114615000814 phosphorylation site [posttranslational modification] 114615000815 intermolecular recognition site; other site 114615000816 dimerization interface [polypeptide binding]; other site 114615000817 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 114615000818 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 114615000819 Prolipoprotein diacylglyceryl transferase; Region: LGT; cl00478 114615000820 Predicted Fe-S oxidoreductases [General function prediction only]; Region: COG1964 114615000821 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster...; Region: Radical_SAM; cd01335 114615000822 FeS/SAM binding site; other site 114615000823 Archaeal/vacuolar-type H+-ATPase subunit I [Energy production and conversion]; Region: NtpI; COG1269 114615000824 Predicted membrane GTPase involved in stress response [Signal transduction mechanisms]; Region: TypA; COG1217 114615000825 TypA (tyrosine phosphorylated protein A)/BipA subfamily. BipA is a protein belonging to the ribosome-binding family of GTPases and is widely distributed in bacteria and plants. BipA was originally described as a protein that is induced in Salmonella...; Region: TypA_BipA; cd01891 114615000826 G1 box; other site 114615000827 putative GEF interaction site [polypeptide binding]; other site 114615000828 GTP/Mg2+ binding site [chemical binding]; other site 114615000829 Switch I region; other site 114615000830 G2 box; other site 114615000831 G3 box; other site 114615000832 Switch II region; other site 114615000833 G4 box; other site 114615000834 G5 box; other site 114615000835 BipA_TypA_II: domain II of BipA (also called TypA) having homology to domain II of the elongation factors (EFs) EF-G and EF-Tu. BipA is a highly conserved protein with global regulatory properties in Escherichia coli. BipA is phosphorylated on a...; Region: BipA_TypA_II; cd03691 114615000836 BipA_TypA_C: a C-terminal portion of BipA or TypA having homology to the C terminal domains of the elongation factors EF-G and EF-2. A member of the ribosome binding GTPase superfamily, BipA is widely distributed in bacteria and plants. BipA is a...; Region: BipA_TypA_C; cd03710 114615000837 Flavin containing amine oxidoreductase; Region: Amino_oxidase; pfam01593 114615000838 Flavin containing amine oxidoreductase; Region: Amino_oxidase; pfam01593 114615000839 putative DNA-binding transcriptional regulator; Provisional; Region: PRK10837 114615000840 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 114615000841 C-terminal substrate binding domain of LysR-type transcriptional regulator CysL, which activates the transcription of the cysJI operon encoding sulfite reductase, contains the type 2 periplasmic binding fold; Region: PBP2_CysL_like; cd08420 114615000842 putative dimerization interface [polypeptide binding]; other site 114615000843 Conserved hypothetical protein 698; Region: Cons_hypoth698; cl01075 114615000844 Protein of unknown function, DUF393; Region: DUF393; cl01136 114615000845 Predicted nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG0702 114615000846 NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, subunit 9, 39 kDa, (NDUFA9) -like, atypical (a) SDRs; Region: NDUFA9_like_SDR_a; cd05271 114615000847 putative NAD(P) binding site [chemical binding]; other site 114615000848 active site 114615000849 Predicted integral membrane protein (DUF2269); Region: DUF2269; cl02335 114615000850 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 114615000851 Coenzyme A binding pocket [chemical binding]; other site 114615000852 Inorganic pyrophosphatase. These enzymes hydrolyze inorganic pyrophosphate (PPi) to two molecules of orthophosphates (Pi). The reaction requires bivalent cations. The enzymes in general exist as homooligomers; Region: pyrophosphatase; cd00412 114615000853 dimer interface [polypeptide binding]; other site 114615000854 substrate binding site [chemical binding]; other site 114615000855 metal binding sites [ion binding]; metal-binding site 114615000856 hypothetical protein; Provisional; Region: PRK08262 114615000857 M20 Peptidase, carboxypeptidase yscS; Region: M20_yscS; cd05674 114615000858 metal binding site [ion binding]; metal-binding site 114615000859 bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate cyclohydrolase; Provisional; Region: PRK14188 114615000860 Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain; Region: THF_DHG_CYH; pfam00763 114615000861 NADP binding domain of methylene-tetrahydrofolate dehydrogenase/cyclohydrolase; Region: NAD_bind_m-THF_DH_Cyclohyd; cd01080 114615000862 homodimer interface [polypeptide binding]; other site 114615000863 NADP binding site [chemical binding]; other site 114615000864 substrate binding site [chemical binding]; other site 114615000865 Uncharacterised ACR, YggU family COG1872; Region: DUF167; cl00811 114615000866 YGGT family; Region: YGGT; cl00508 114615000867 GMP synthase - Glutamine amidotransferase domain [Nucleotide transport and metabolism]; Region: GuaA; COG0518 114615000868 Subgroup of proteins having the Type 1 glutamine amidotransferase (GATase1) domain; Region: GATase1_1; cd01741 114615000869 catalytic triad [active] 114615000870 Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300 114615000871 classical (c) SDRs; Region: SDR_c; cd05233 114615000872 NAD(P) binding site [chemical binding]; other site 114615000873 active site 114615000874 tellurium resistance terB-like protein, subgroup 2; Region: terB_like_2; cd07313 114615000875 putative metal binding site [ion binding]; other site 114615000876 Cytochrome P450; Region: p450; cl12078 114615000877 Alpha/beta hydrolase of unknown function (DUF915); Region: DUF915; cl14892 114615000878 alpha/beta hydrolase fold; Region: Abhydrolase_1; pfam00561 114615000879 acetolactate synthase; Reviewed; Region: PRK08617 114615000880 Bacterial protein of unknown function (DUF894); Region: DUF894; pfam05977 114615000881 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 114615000882 Polysaccharide deacetylase; Region: Polysacc_deac_1; cl12061 114615000883 putative PEP-CTERM system TPR-repeat lipoprotein; Region: PEP_TPR_lipo; TIGR02917 114615000884 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi...; Region: TPR; cd00189 114615000885 TPR motif; other site 114615000886 GSCFA family; Region: GSCFA; pfam08885 114615000887 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cl01116 114615000888 putative Helix-turn-helix domain of transposase IS66; Region: HTH_Tnp_IS66; cl14891 114615000889 putative Helix-turn-helix domain of transposase IS66; Region: HTH_Tnp_IS66; cl14891 114615000890 Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050 114615000891 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster...; Region: Radical_SAM; cl15259 114615000892 Uncharacterized membrane-bound protein [Function unknown]; Region: COG3898 114615000893 HemY protein N-terminus; Region: HemY_N; pfam07219 114615000894 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4223 114615000895 Uroporphyrinogen-III synthase (HemD) catalyzes the asymmetrical cyclization of tetrapyrrole (linear) to uroporphyrinogen-III, the fourth step in the biosynthesis of heme. This ubiquitous enzyme is present in eukaryotes, bacteria and archaea. Mutations...; Region: HemD; cd06578 114615000896 active site 114615000897 Uroporphyrinogen-III synthase HemD; Region: HEM4; pfam02602 114615000898 UGMP family protein; Validated; Region: PRK09604 114615000899 Inactive homolog of metal-dependent proteases, putative molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: COG1214; cl14000 114615000900 NAD(P)H-dependent glycerol-3-phosphate dehydrogenase; Validated; Region: gpsA; PRK00094 114615000901 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 114615000902 NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus; Region: NAD_Gly3P_dh_C; pfam07479 114615000903 EVE domain; Region: EVE; cl00728 114615000904 Ammonium Transporter Family; Region: Ammonium_transp; cl03012 114615000905 NIF3 (NGG1p interacting factor 3); Region: NIF3; cl00412 114615000906 Ammonium Transporter Family; Region: Ammonium_transp; cl03012 114615000907 NIF3 (NGG1p interacting factor 3); Region: NIF3; cl00412 114615000908 Acyl-CoA thioesterase [Lipid metabolism]; Region: TesB; COG1946 114615000909 Thioesterase II (TEII) is thought to regenerate misprimed nonribosomal peptide synthetases (NRPSs) as well as modular polyketide synthases (PKSs) by hydrolyzing acetyl groups bound to the peptidyl carrier protein (PCP) and acyl carrier protein (ACP)...; Region: Thioesterase_II_repeat2; cd03445 114615000910 active site 114615000911 Thioesterase II (TEII) is thought to regenerate misprimed nonribosomal peptide synthetases (NRPSs) as well as modular polyketide synthases (PKSs) by hydrolyzing acetyl groups bound to the peptidyl carrier protein (PCP) and acyl carrier protein (ACP)...; Region: Thioesterase_II_repeat1; cd03444 114615000912 catalytic triad [active] 114615000913 dimer interface [polypeptide binding]; other site 114615000914 2-octaprenyl-6-methoxyphenyl hydroxylase; Provisional; Region: PRK07333 114615000915 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 114615000916 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 114615000917 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 114615000918 Trm112p-like protein; Region: Trm112p; cl01066 114615000919 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 114615000920 Iron permease FTR1 family; Region: FTR1; cl00475 114615000921 Uncharacterized protein, similar to the N-terminal domain of Lon protease [General function prediction only]; Region: COG2802 114615000922 Thioredoxin domain-containing protein [Posttranslational modification, protein turnover, chaperones]; Region: COG3118 114615000923 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 114615000924 Caspase, interleukin-1 beta converting enzyme (ICE) homologues; Cysteine-dependent aspartate-directed proteases that mediate programmed cell death (apoptosis). Caspases are synthesized as inactive zymogens and activated by proteolysis of the peptide...; Region: CASc; cl00042 114615000925 Nicotinic acid phosphoribosyltransferase [Coenzyme metabolism]; Region: PncB; COG1488 114615000926 Phosphoribosyltransferase (PRTase) type II; This family contains two enzymes that play an important role in NAD production by either allowing quinolinic acid (QA) , quinolinate phosphoribosyl transferase (QAPRTase), or nicotinic acid (NA), nicotinate...; Region: PRTase_typeII; cl12019 114615000927 active site 114615000928 Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154 114615000929 GGCT-like domains, also called AIG2-like family. Gamma-glutamyl cyclotransferase (GGCT) catalyzes the formation of pyroglutamic acid (5-oxoproline) from dipeptides containing gamma-glutamyl, and is a dimeric protein. In Homo sapiens, the protein is...; Region: GGCT_like; cl11426 114615000930 Glucose/sorbosone dehydrogenases [Carbohydrate transport and metabolism]; Region: COG2133 114615000931 Glucose / Sorbosone dehydrogenase; Region: GSDH; pfam07995 114615000932 Cytochrome c; Region: Cytochrom_C; cl11414 114615000933 Cytochrome c; Region: Cytochrom_C; cl11414 114615000934 2-dehydropantoate 2-reductase; Provisional; Region: PRK12921 114615000935 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 114615000936 Ketopantoate reductase PanE/ApbA C terminal; Region: ApbA_C; pfam08546 114615000937 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: FabG; COG1028 114615000938 classical (c) SDR, subgroup 10; Region: SDR_c10; cd05373 114615000939 putative NAD(P) binding site [chemical binding]; other site 114615000940 active site 114615000941 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cl01116 114615000942 putative transposase OrfB; Reviewed; Region: PHA02517 114615000943 Integrase core domain; Region: rve; cl01316 114615000944 2-hydroxychromene-2-carboxylate isomerase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: NahD; COG3917 114615000945 DsbA family, 2-hydroxychromene-2-carboxylate (HCCA) isomerase subfamily; HCCA isomerase is a glutathione (GSH) dependent enzyme involved in the naphthalene catabolic pathway. It converts HCCA, a hemiketal formed spontaneously after ring cleavage of 1,2-; Region: DsbA_HCCA_Iso; cd03022 114615000946 putative catalytic residue [active] 114615000947 Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534 114615000948 MatE; Region: MatE; cl10513 114615000949 MatE; Region: MatE; cl10513 114615000950 Uncharacterized protein conserved in bacteria (DUF2239); Region: DUF2239; cl01461 114615000951 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 114615000952 GST_N family, Saccharomyces cerevisiae GTT1-like subfamily; composed of predominantly uncharacterized proteins with similarity to the S. cerevisiae GST protein, GTT1, and the Schizosaccharomyces pombe GST-III. GSTs are cytosolic dimeric proteins...; Region: GST_N_GTT1_like; cd03046 114615000953 putative C-terminal domain interface [polypeptide binding]; other site 114615000954 putative GSH binding site (G-site) [chemical binding]; other site 114615000955 putative dimer interface [polypeptide binding]; other site 114615000956 C-terminal, alpha helical domain of GTT1-like Glutathione S-transferases; Region: GST_C_GTT1_like; cd03189 114615000957 putative N-terminal domain interface [polypeptide binding]; other site 114615000958 putative dimer interface [polypeptide binding]; other site 114615000959 putative substrate binding pocket (H-site) [chemical binding]; other site 114615000960 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 114615000961 Beta-lactamase; Region: Beta-lactamase; cl01009 114615000962 Gamma-glutamyltransferase [Amino acid transport and metabolism]; Region: Ggt; cl08040 114615000963 Gamma-glutamyltranspeptidase; Region: G_glu_transpept; pfam01019 114615000964 Permeases of the major facilitator superfamily [General function prediction only]; Region: COG2270 114615000965 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 114615000966 putative substrate translocation pore; other site 114615000967 bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; Provisional; Region: purH; PRK00881 114615000968 Inosine monophosphate cyclohydrolase domain. This is the N-terminal domain in the purine biosynthesis pathway protein ATIC (purH). The bifunctional ATIC protein contains a C-terminal ATIC formylase domain that formylates 5-aminoimidazole-4-carboxamide-; Region: IMPCH; cd01421 114615000969 purine monophosphate binding site [chemical binding]; other site 114615000970 dimer interface [polypeptide binding]; other site 114615000971 putative catalytic residues [active] 114615000972 AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; cl03362 114615000973 AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; cl03362 114615000974 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5360 114615000975 Heparinase II/III-like protein; Region: Hepar_II_III; pfam07940 114615000976 16S rRNA methyltransferase B; Provisional; Region: PRK10901 114615000977 RNA binding domain of NusB (N protein-Utilization Substance B) and Sun (also known as RrmB or Fmu) proteins. This family includes two orthologous groups exemplified by the transcription termination factor NusB and the N-terminal domain of the rRNA-...; Region: NusB_Sun; cl00223 114615000978 putative RNA binding site [nucleotide binding]; other site 114615000979 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cd02440 114615000980 S-adenosylmethionine binding site [chemical binding]; other site 114615000981 Uncharacterized conserved small protein [Function unknown]; Region: COG5508 114615000982 Protein of unknown function (DUF1674); Region: DUF1674; pfam07896 114615000983 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 114615000984 acetyl-CoA synthetase; Provisional; Region: PRK00174 114615000985 Domain of unknown function (DUF3448); Region: DUF3448; pfam11930 114615000986 Acyl-protein synthetase, LuxE; Region: LuxE; cl10450 114615000987 DNA topoisomerase IB, C-terminal catalytic domain. Topoisomerase I promotes the relaxation of both positive and negative DNA superhelical tension by introducing a transient single-stranded break in duplex DNA. This function is vital for the processes...; Region: Topo_IB_C; cd00659 114615000988 DNA binding site [nucleotide binding] 114615000989 active site 114615000990 Int/Topo IB signature motif; other site 114615000991 catalytic residues [active] 114615000992 Fasciclin domain; Region: Fasciclin; cl02663 114615000993 Cytochrome b (N-terminus)/b6/petB: Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria...; Region: Cytochrome_b_N; cl00859 114615000994 bacterial subgroup of the sulfite oxidase (SO) family of molybdopterin binding domains. This domain is found in a variety of oxidoreductases. Common features of all known members of this family, like sulfite oxidase and nitrite reductase, are that they...; Region: bact_SO_family_Moco; cd02108 114615000995 Moco binding site; other site 114615000996 metal coordination site [ion binding]; other site 114615000997 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 114615000998 putative substrate translocation pore; other site 114615000999 Isocitrate/isopropylmalate dehydrogenase; Region: Iso_dh; cl00445 114615001000 aspartate-semialdehyde dehydrogenase; Provisional; Region: PRK14874 114615001001 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 114615001002 Semialdehyde dehydrogenase, dimerisation domain; Region: Semialdhyde_dhC; pfam02774 114615001003 Uncharacterized protein family, UPF0114; Region: UPF0114; cl01078 114615001004 Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA_cladeB; cd00884 114615001005 active site clefts [active] 114615001006 zinc binding site [ion binding]; other site 114615001007 dimer interface [polypeptide binding]; other site 114615001008 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl09155 114615001009 Cytochrome c; Region: Cytochrom_C; cl11414 114615001010 Aconatase-like swivel domain of 3-isopropylmalate dehydratase and related uncharacterized proteins. 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate 3-...; Region: IPMI_Swivel; cd01577 114615001011 substrate binding site [chemical binding]; other site 114615001012 Possibl zinc metallo-peptidase; Region: DUF1025; cl01577 114615001013 3-isopropylmalate dehydratase large subunit; Reviewed; Region: PRK00402 114615001014 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate; Region: IPMI; cd01583 114615001015 substrate binding site [chemical binding]; other site 114615001016 ligand binding site [chemical binding]; other site 114615001017 Ribosomal protein L19; Region: Ribosomal_L19; cl00406 114615001018 tRNA (Guanine-1)-methyltransferase; Region: tRNA_m1G_MT; cl00407 114615001019 RimM N-terminal domain; Region: RimM; pfam01782 114615001020 16S rRNA-processing protein RimM; Provisional; Region: rimM; PRK13828 114615001021 Photosynthetic reaction center (RC) complex, subunit H; RC is an integral membrane protein-pigment complex which catalyzes light-induced reduction of ubiquinone to ubiquinol, generating a transmembrane electrochemical gradient of protons used to...; Region: PRCH; cl09959 114615001022 Ribosomal protein S16; Region: Ribosomal_S16; cl00368 114615001023 signal recognition particle protein; Provisional; Region: PRK10867 114615001024 SRP54-type protein, helical bundle domain; Region: SRP54_N; cl03758 114615001025 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115 114615001026 P loop; other site 114615001027 GTP binding site [chemical binding]; other site 114615001028 Signal peptide binding domain; Region: SRP_SPB; pfam02978 114615001029 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 114615001030 Protein of unknown function (DUF541); Region: SIMPL; cl01077 114615001031 Bacterial transcription activator, effector binding domain; Region: AraC_E_bind; cl01368 114615001032 diaminopimelate epimerase; Provisional; Region: dapF; PRK00450 114615001033 Diaminopimelate epimerase; Region: DAP_epimerase; cl14668 114615001034 Diaminopimelate epimerase; Region: DAP_epimerase; cl14668 114615001035 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 114615001036 MiaB-like tRNA modifying enzyme; Region: MiaB-like-C; TIGR01579 114615001037 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster...; Region: Radical_SAM; cd01335 114615001038 FeS/SAM binding site; other site 114615001039 PseudoU_synth_RsuA/RluD: Pseudouridine synthase, RsuA/RluD family. This group is comprised of eukaryotic, bacterial and archeal proteins similar to eight site specific Escherichia coli pseudouridine synthases: RsuA, RluA, RluB, RluC, RluD, RluE, RluF...; Region: PseudoU_synth_RluCD_like; cd02869 114615001040 active site 114615001041 PseudoU_synth_RsuA/RluD: Pseudouridine synthase, RsuA/RluD family. This group is comprised of eukaryotic, bacterial and archeal proteins similar to eight site specific Escherichia coli pseudouridine synthases: RsuA, RluA, RluB, RluC, RluD, RluE, RluF...; Region: PseudoU_synth_RluCD_like; cd02869 114615001042 signal recognition particle-docking protein FtsY; Provisional; Region: PRK10416 114615001043 SRP54-type protein, helical bundle domain; Region: SRP54_N; cl03758 114615001044 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115 114615001045 P loop; other site 114615001046 GTP binding site [chemical binding]; other site 114615001047 Intracellular septation protein A; Region: IspA; cl01098 114615001048 TlpA-like family, DsbE (also known as CcmG and CycY) subfamily; DsbE is a membrane-anchored, periplasmic TRX-like reductase containing a CXXC motif that specifically donates reducing equivalents to apocytochrome c via CcmH, another cytochrome c...; Region: TlpA_like_DsbE; cd03010 114615001049 catalytic residues [active] 114615001050 central insert; other site 114615001051 Cytochrome C assembly protein; Region: Cytochrom_C_asm; cl00504 114615001052 CcmB protein; Region: CcmB; cl01016 114615001053 cytochrome c biogenesis protein CcmA; Provisional; Region: PRK13539 114615001054 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 114615001055 Walker A/P-loop; other site 114615001056 ATP binding site [chemical binding]; other site 114615001057 Q-loop/lid; other site 114615001058 ABC transporter signature motif; other site 114615001059 Walker B; other site 114615001060 D-loop; other site 114615001061 H-loop/switch region; other site 114615001062 aconitate hydratase; Validated; Region: PRK09277 114615001063 Aconitase A catalytic domain; Region: AcnA_IRP; cd01586 114615001064 substrate binding site [chemical binding]; other site 114615001065 ligand binding site [chemical binding]; other site 114615001066 Aconitase A swivel domain. This is the major form of the TCA cycle enzyme aconitate hydratase, also known as aconitase and citrate hydro-lyase. It includes bacterial and archaeal aconitase A, and the eukaryotic cytosolic form of aconitase. This group...; Region: AcnA_IRP_Swivel; cd01580 114615001067 substrate binding site [chemical binding]; other site 114615001068 Protein of unknown function (DUF1223); Region: DUF1223; cl10501 114615001069 Protein of unknown function (DUF2794); Region: DUF2794; pfam10984 114615001070 Sortase and related acyltransferases [Cell envelope biogenesis, outer membrane]; Region: COG1247 114615001071 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 114615001072 Coenzyme A binding pocket [chemical binding]; other site 114615001073 Bacterial BAX inhibitor (BI)-1/YccA-like proteins; Region: BI-1-like_bacterial; cd10432 114615001074 Predicted ABC-type transport system involved in lysophospholipase L1 biosynthesis, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3127 114615001075 FtsX-like permease family; Region: FtsX; pfam02687 114615001076 Predicted ABC-type transport system involved in lysophospholipase L1 biosynthesis, ATPase component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG4181 114615001077 This family is comprised of MJ0796 ATP-binding cassette, macrolide-specific ABC-type efflux carrier (MacAB), and proteins involved in cell division (FtsE), and release of liporoteins from the cytoplasmic membrane (LolCDE). They are clustered together...; Region: ABC_MJ0796_Lo1CDE_FtsE; cd03255 114615001078 Walker A/P-loop; other site 114615001079 ATP binding site [chemical binding]; other site 114615001080 Q-loop/lid; other site 114615001081 ABC transporter signature motif; other site 114615001082 Walker B; other site 114615001083 D-loop; other site 114615001084 H-loop/switch region; other site 114615001085 Lysophospholipase L1-like subgroup of SGNH-hydrolases. The best characterized member in this family is TesA, an E. coli periplasmic protein with thioesterase, esterase, arylesterase, protease and lysophospholipase activity; Region: Lysophospholipase_L1_like; cd01822 114615001086 active site 114615001087 oxyanion hole [active] 114615001088 switch loop; other site 114615001089 catalytic triad [active] 114615001090 2'-5' RNA ligase; Region: 2_5_ligase; TIGR02258 114615001091 2',5' RNA ligase family; Region: 2_5_RNA_ligase; pfam02834 114615001092 2',5' RNA ligase family; Region: 2_5_RNA_ligase; pfam02834 114615001093 Predicted ATPase [General function prediction only]; Region: COG1485 114615001094 malate dehydrogenase; Reviewed; Region: PRK06223 114615001095 L-lactate dehydrogenase-like malate dehydrogenase proteins; Region: LDH-like_MDH; cd01339 114615001096 NAD(P) binding site [chemical binding]; other site 114615001097 dimer interface [polypeptide binding]; other site 114615001098 tetramer (dimer of dimers) interface [polypeptide binding]; other site 114615001099 substrate binding site [chemical binding]; other site 114615001100 succinyl-CoA synthetase subunit beta; Provisional; Region: sucC; PRK00696 114615001101 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; cl03087 114615001102 CoA-ligase; Region: Ligase_CoA; pfam00549 114615001103 succinyl-CoA synthetase subunit alpha; Validated; Region: PRK05678 114615001104 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 114615001105 CoA-ligase; Region: Ligase_CoA; pfam00549 114615001106 2-oxoglutarate dehydrogenase E1 component; Reviewed; Region: sucA; PRK09404 114615001107 TPP-binding module; composed of proteins similar to the E1 component of the 2-oxoglutarate dehydrogenase multienzyme complex (OGDC). OGDC catalyzes the oxidative decarboxylation of 2-oxoglutarate to succinyl-CoA and carbon dioxide, a key reaction of...; Region: TPP_E1_OGDC_like; cd02016 114615001108 TPP-binding site [chemical binding]; other site 114615001109 Pyrimidine (PYR) binding domain of thiamine pyrophosphate (TPP)-dependent enzymes; Region: TPP_enzyme_PYR; cl11410 114615001110 dihydrolipoamide succinyltransferase; Validated; Region: PRK05704 114615001111 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 114615001112 E3 interaction surface; other site 114615001113 lipoyl attachment site [posttranslational modification]; other site 114615001114 e3 binding domain; Region: E3_binding; pfam02817 114615001115 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; cl02008 114615001116 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 114615001117 short chain dehydrogenase; Provisional; Region: PRK06123 114615001118 NAD(P) binding site [chemical binding]; other site 114615001119 active site 114615001120 dihydrolipoamide dehydrogenase; Validated; Region: PRK06292 114615001121 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 114615001122 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 114615001123 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 114615001124 site-specific tyrosine recombinase XerC; Reviewed; Region: xerC; PRK00236 114615001125 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 114615001126 DNA binding site [nucleotide binding] 114615001127 Int/Topo IB signature motif; other site 114615001128 active site 114615001129 primosome assembly protein PriA; Validated; Region: PRK05580 114615001130 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 114615001131 ATP binding site [chemical binding]; other site 114615001132 putative Mg++ binding site [ion binding]; other site 114615001133 Rare lipoprotein A (RlpA)-like double-psi beta-barrel; Region: DPBB_1; cl04011 114615001134 ATP synthase B/B' CF(0); Region: ATP-synt_B; cl07975 114615001135 ATP synthase delta (OSCP) subunit; Region: OSCP; pfam00213 114615001136 F0F1 ATP synthase subunit alpha; Validated; Region: PRK09281 114615001137 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; cl15275 114615001138 F1 ATP synthase alpha, central domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a proton gradient to...; Region: F1_ATPase_alpha; cd01132 114615001139 beta subunit interaction interface [polypeptide binding]; other site 114615001140 Walker A motif; other site 114615001141 ATP binding site [chemical binding]; other site 114615001142 Walker B motif; other site 114615001143 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 114615001144 ATP synthase; Region: ATP-synt; cl00365 114615001145 F0F1 ATP synthase subunit beta; Validated; Region: PRK09280 114615001146 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; cl15275 114615001147 F1 ATP synthase beta subunit, nucleotide-binding domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a...; Region: F1-ATPase_beta; cd01133 114615001148 alpha subunit interaction interface [polypeptide binding]; other site 114615001149 Walker A motif; other site 114615001150 ATP binding site [chemical binding]; other site 114615001151 Walker B motif; other site 114615001152 inhibitor binding site; inhibition site 114615001153 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 114615001154 F0F1 ATP synthase subunit epsilon; Provisional; Region: atpC; PRK13448 114615001155 ATP synthase, Delta/Epsilon chain, beta-sandwich domain; Region: ATP-synt_DE_N; cl10033 114615001156 cyclase homology domain; Region: CHD; cd07302 114615001157 nucleotidyl binding site; other site 114615001158 metal binding site [ion binding]; metal-binding site 114615001159 dimer interface [polypeptide binding]; other site 114615001160 Diadenosine tetraphosphate (Ap4A) hydrolase is a member of the Nudix hydrolase superfamily. Members of this family are well represented in a variety of prokaryotic and eukaryotic organisms. Phylogenetic analysis reveals two distinct subgroups where...; Region: Ap4A_hydrolase_plant_like; cd03671 114615001161 putative active site [active] 114615001162 Ap4A binding site [chemical binding]; other site 114615001163 nudix motif; other site 114615001164 putative metal binding site [ion binding]; other site 114615001165 Diadenosine tetraphosphate (Ap4A) hydrolase is a member of the Nudix hydrolase superfamily. Members of this family are well represented in a variety of prokaryotic and eukaryotic organisms. Phylogenetic analysis reveals two distinct subgroups where...; Region: Ap4A_hydrolase_plant_like; cd03671 114615001166 putative active site [active] 114615001167 Ap4A binding site [chemical binding]; other site 114615001168 nudix motif; other site 114615001169 putative metal binding site [ion binding]; other site 114615001170 Divergent polysaccharide deacetylase; Region: Polysacc_deac_2; cl04721 114615001171 Periplasmic protease [Cell envelope biogenesis, outer membrane]; Region: Prc; COG0793 114615001172 C-terminal processing peptidase family S41; Region: Peptidase_S41; cl02526 114615001173 PDZ domain of C-terminal processing-, tail-specific-, and tricorn proteases, which function in posttranslational protein processing, maturation, and disassembly or degradation, in Bacteria, Archaea, and plant chloroplasts. May be responsible for...; Region: PDZ_CTP_protease; cd00988 114615001174 protein binding site [polypeptide binding]; other site 114615001175 C-terminal processing peptidase; serine protease family S41; Region: Peptidase_S41_CPP; cd07560 114615001176 Catalytic dyad [active] 114615001177 Membrane-bound metallopeptidase [Cell division and chromosome partitioning]; Region: COG4942 114615001178 Peptidase family M23; Region: Peptidase_M23; pfam01551 114615001179 Predicted SPOUT methyltransferase; Region: SPOUT_MTase; cl00679 114615001180 Domain of unknown function DUF143; Region: DUF143; cl00519 114615001181 Nicotinamide/nicotinate mononucleotide adenylyltransferase; Region: NMNAT; cd02165 114615001182 active site 114615001183 (T/H)XGH motif; other site 114615001184 Gamma-glutamyl phosphate reductase (GPR), aldehyde dehydrogenase families 18 and 19; Region: ALDH_F18-19_ProA-GPR; cd07079 114615001185 gamma-glutamyl phosphate reductase; Region: proA; TIGR00407 114615001186 putative catalytic cysteine [active] 114615001187 gamma-glutamyl kinase; Provisional; Region: PRK05429 114615001188 AAK_G5K_ProB: Glutamate-5-kinase (G5K) catalyzes glutamate-dependent ATP cleavage; G5K transfers the terminal phosphoryl group of ATP to the gamma-carboxyl group of glutamate, in the first and controlling step of proline (and, in mammals, ornithine)...; Region: AAK_G5K_ProB; cd04242 114615001189 nucleotide binding site [chemical binding]; other site 114615001190 homotetrameric interface [polypeptide binding]; other site 114615001191 putative phosphate binding site [ion binding]; other site 114615001192 putative allosteric binding site; other site 114615001193 PUA domain; Region: PUA; cl00607 114615001194 GTPase CgtA; Reviewed; Region: obgE; PRK12299 114615001195 GTP1/OBG; Region: GTP1_OBG; pfam01018 114615001196 Obg subfamily. The Obg nucleotide binding protein subfamily has been implicated in stress response, chromosome partitioning, replication initiation, mycelium development, and sporulation. Obg proteins are among a large group of GTP binding proteins...; Region: Obg; cd01898 114615001197 G1 box; other site 114615001198 GTP/Mg2+ binding site [chemical binding]; other site 114615001199 Switch I region; other site 114615001200 G2 box; other site 114615001201 G3 box; other site 114615001202 Switch II region; other site 114615001203 G4 box; other site 114615001204 G5 box; other site 114615001205 Predicted permeases [General function prediction only]; Region: RarD; COG2962 114615001206 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 114615001207 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 114615001208 Ribosomal L27 protein; Region: Ribosomal_L27; cl00359 114615001209 Ribosomal prokaryotic L21 protein; Region: Ribosomal_L21p; cl00382 114615001210 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 114615001211 Predicted unusual protein kinase [General function prediction only]; Region: AarF; COG0661 114615001212 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 114615001213 FAD binding domain of DNA photolyase; Region: FAD_binding_7; pfam03441 114615001214 Predicted NAD/FAD-dependent oxidoreductase [General function prediction only]; Region: COG3380 114615001215 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 114615001216 Predicted NAD/FAD-dependent oxidoreductase [General function prediction only]; Region: COG3380 114615001217 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 114615001218 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; cl11611 114615001219 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 114615001220 AP endonuclease family 2 C terminus; Region: AP_endonuc_2_N; pfam07582 114615001221 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 114615001222 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cl00159 114615001223 [2Fe-2S] binding domain; Region: Fer2_2; pfam01799 114615001224 Aerobic-type carbon monoxide dehydrogenase, large subunit CoxL/CutL homologs [Energy production and conversion]; Region: CoxL; COG1529 114615001225 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 114615001226 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; cl03161 114615001227 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 114615001228 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 114615001229 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 114615001230 Transcriptional regulator containing an amidase domain and an AraC-type DNA-binding HTH domain [Transcription]; Region: COG4977 114615001231 AraC transcriptional regulators having a Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GATase1_AraC_1; cd03137 114615001232 conserved cys residue [active] 114615001233 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 114615001234 Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300 114615001235 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 114615001236 NAD(P) binding site [chemical binding]; other site 114615001237 active site 114615001238 Predicted restriction endonuclease [Defense mechanisms]; Region: COG3440 114615001239 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 114615001240 Phage integrase family; Region: Phage_integrase; pfam00589 114615001241 DNA binding site [nucleotide binding] 114615001242 Int/Topo IB signature motif; other site 114615001243 active site 114615001244 Superfamily of nucleases including Short Patch Repair (Vsr) Endonucleases, archaeal Holliday junction resolvases, MutH methy-directed DNA mismatch-repair endonucleases, and catalytic domains of many restriction endonucleases, such as EcoRI, BamHI, and...; Region: Restriction_endonuclease_like; cl00277 114615001245 TSCPD domain; Region: TSCPD; cl14834 114615001246 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 114615001247 Walker A motif; other site 114615001248 ATP binding site [chemical binding]; other site 114615001249 Walker B motif; other site 114615001250 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl15258 114615001251 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins...; Region: HNHc; cl00083 114615001252 Uncharacterised ACR, COG2135; Region: DUF159; cl03646 114615001253 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cl12011 114615001254 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and...; Region: Aldo_ket_red; cd06660 114615001255 Predicted oxidoreductases (related to aryl-alcohol dehydrogenases) [Energy production and conversion]; Region: Tas; COG0667 114615001256 active site 114615001257 catalytic tetrad [active] 114615001258 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961 114615001259 Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cd00338 114615001260 catalytic residues [active] 114615001261 catalytic nucleophile [active] 114615001262 Recombinase; Region: Recombinase; pfam07508 114615001263 Uncharacterised ACR, COG2135; Region: DUF159; cl03646 114615001264 hypothetical protein; Provisional; Region: PRK11770 114615001265 Domain of unknown function (DUF307); Region: DUF307; pfam03733 114615001266 Domain of unknown function (DUF307); Region: DUF307; pfam03733 114615001267 PAS fold; Region: PAS_7; pfam12860 114615001268 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459 114615001269 PAS fold; Region: PAS_4; pfam08448 114615001270 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 114615001271 metal binding site [ion binding]; metal-binding site 114615001272 active site 114615001273 I-site; other site 114615001274 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 114615001275 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 114615001276 TM-ABC transporter signature motif; other site 114615001277 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 114615001278 TM-ABC transporter signature motif; other site 114615001279 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410 114615001280 LivF (TM1139) is part of the LIV-I bacterial ABC-type two-component transport system that imports neutral, branched-chain amino acids. The E. coli branched-chain amino acid transporter comprises a heterodimer of ABC transporters (LivF and LivG), a...; Region: ABC_TM1139_LivF_branched; cd03224 114615001281 Walker A/P-loop; other site 114615001282 ATP binding site [chemical binding]; other site 114615001283 Q-loop/lid; other site 114615001284 ABC transporter signature motif; other site 114615001285 Walker B; other site 114615001286 D-loop; other site 114615001287 H-loop/switch region; other site 114615001288 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411 114615001289 The Mj1267/LivG ABC transporter subfamily is involved in the transport of the hydrophobic amino acids leucine, isoleucine and valine. MJ1267 is a branched-chain amino acid transporter with 29% similarity to both the LivF and LivG components of the E...; Region: ABC_Mj1267_LivG_branched; cd03219 114615001290 Walker A/P-loop; other site 114615001291 ATP binding site [chemical binding]; other site 114615001292 Q-loop/lid; other site 114615001293 ABC transporter signature motif; other site 114615001294 Walker B; other site 114615001295 D-loop; other site 114615001296 H-loop/switch region; other site 114615001297 ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683 114615001298 Periplasmic solute-binding domain of active transport proteins found in gram-negative and gram-positive bacteria; Region: PBP1_SBP_like_2; cd06328 114615001299 putative ligand binding site [chemical binding]; other site 114615001300 PAS domain S-box; Region: sensory_box; TIGR00229 114615001301 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 114615001302 metal binding site [ion binding]; metal-binding site 114615001303 active site 114615001304 I-site; other site 114615001305 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 114615001306 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920 114615001307 Histidine kinase; Region: HisKA_2; cl06527 114615001308 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 114615001309 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 114615001310 NAD(P) binding site [chemical binding]; other site 114615001311 active site 114615001312 Cytochrome P450; Region: p450; cl12078 114615001313 3-epi-6-deoxocathasterone 23-monooxygenase; Provisional; Region: PLN03141 114615001314 Response regulator receiver domain; Region: Response_reg; pfam00072 114615001315 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156 114615001316 active site 114615001317 phosphorylation site [posttranslational modification] 114615001318 intermolecular recognition site; other site 114615001319 dimerization interface [polypeptide binding]; other site 114615001320 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 114615001321 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases [Energy production and conversion]; Region: COG2141 114615001322 esterase, PHB depolymerase family; Region: esterase_phb; TIGR01840 114615001323 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 114615001324 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 114615001325 alpha,alpha-phosphotrehalase; Region: trehalose_treC; TIGR02403 114615001326 Alpha amylase, catalytic domain; Region: Alpha-amylase; cl07893 114615001327 Domain of unknown function (DUF3459); Region: DUF3459; pfam11941 114615001328 trehalose synthase; Region: treS_nterm; TIGR02456 114615001329 Alpha amylase, catalytic domain; Region: Alpha-amylase; cl07893 114615001330 Protein of unknown function (DUF1052); Region: DUF1052; cl02197 114615001331 Response regulator consisting of a CheY-like receiver domain and a Fis-type HTH domain [Signal transduction mechanisms / Transcription]; Region: COG4567 114615001332 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156 114615001333 active site 114615001334 phosphorylation site [posttranslational modification] 114615001335 intermolecular recognition site; other site 114615001336 dimerization interface [polypeptide binding]; other site 114615001337 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 114615001338 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via trans-...; Region: HisKA; cl00080 114615001339 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 114615001340 ATP binding site [chemical binding]; other site 114615001341 Mg2+ binding site [ion binding]; other site 114615001342 G-X-G motif; other site 114615001343 ABC-type Na+ transport system, ATPase component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatA; COG4555 114615001344 This family of ATP-binding proteins belongs to a multisubunit transporter involved in drug resistance (BcrA and DrrA), nodulation, lipid transport, and lantibiotic immunity. In bacteria and archaea, these transporters usually include an ATP-binding...; Region: ABC_DR_subfamily_A; cd03230 114615001345 Walker A/P-loop; other site 114615001346 ATP binding site [chemical binding]; other site 114615001347 Q-loop/lid; other site 114615001348 ABC transporter signature motif; other site 114615001349 Walker B; other site 114615001350 D-loop; other site 114615001351 H-loop/switch region; other site 114615001352 ABC-2 type transporter; Region: ABC2_membrane; cl11417 114615001353 polyhydroxyalkanoate depolymerase, intracellular; Region: PHB_depoly_PhaZ; TIGR01849 114615001354 PHB de-polymerase C-terminus; Region: PHB_depo_C; cl14907 114615001355 Protein of unknown function DUF45; Region: DUF45; cl00636 114615001356 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459 114615001357 cyclic-di-GMP phosphodiesterase; Provisional; Region: PRK11359 114615001358 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 114615001359 putative active site [active] 114615001360 heme pocket [chemical binding]; other site 114615001361 GAF domain; Region: GAF; cl00853 114615001362 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 114615001363 metal binding site [ion binding]; metal-binding site 114615001364 active site 114615001365 I-site; other site 114615001366 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 114615001367 Transglycosylase; Region: Transgly; cl07896 114615001368 penicillin-binding protein, 1A family; Region: PBP_1a_fam; TIGR02074 114615001369 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01039 114615001370 Protein of unknown function (DUF1330); Region: DUF1330; cl02288 114615001371 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 114615001372 dimerization interface [polypeptide binding]; other site 114615001373 putative DNA binding site [nucleotide binding]; other site 114615001374 putative Zn2+ binding site [ion binding]; other site 114615001375 Putative hydrophobic ligand-binding SRPBCC domain of Micromonospora echinospora CalC, human Aha1, and related proteins; Region: SRPBCC_CalC_Aha1-like; cd07814 114615001376 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017 114615001377 oligomer interface [polypeptide binding]; other site 114615001378 active site residues [active] 114615001379 ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683 114615001380 Type I periplasmic ligand-binding domain of uncharacterized ABC (ATPase Binding Cassette)-type active transport systems that are predicted to be involved in uptake of amino acids, peptides, or inorganic ions; Region: PBP1_ABC_ligand_binding_like_8; cd06343 114615001381 putative ligand binding site [chemical binding]; other site 114615001382 ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683 114615001383 Type I periplasmic ligand-binding domain of uncharacterized ABC (ATPase Binding Cassette)-type active transport systems that are predicted to be involved in uptake of amino acids, peptides, or inorganic ions; Region: PBP1_ABC_ligand_binding_like_8; cd06343 114615001384 putative ligand binding site [chemical binding]; other site 114615001385 Protein of unknown function (DUF1304); Region: DUF1304; cl01533 114615001386 PII uridylyl-transferase; Provisional; Region: PRK05092 114615001387 Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401 114615001388 metal binding triad; other site 114615001389 GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335 114615001390 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cl00076 114615001391 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-...; Region: CBS_pair; cl09141 114615001392 C-terminal ACT domains of the bacterial signal-transducing uridylyltransferase /uridylyl-removing (UUR) enzyme, GlnD and related domains; Region: ACT_ACR-UUR-like_2; cd04899 114615001393 NMT1/THI5 like; Region: NMT1; pfam09084 114615001394 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and...; Region: PBPb; cd00134 114615001395 substrate binding pocket [chemical binding]; other site 114615001396 membrane-bound complex binding site; other site 114615001397 hinge residues; other site 114615001398 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261 114615001399 dimer interface [polypeptide binding]; other site 114615001400 conserved gate region; other site 114615001401 putative PBP binding loops; other site 114615001402 ABC-ATPase subunit interface; other site 114615001403 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 114615001404 NrtD and SsuB are the ATP-binding subunits of the bacterial ABC-type nitrate and sulfonate transport systems, respectively. ABC transporters are a large family of proteins involved in the transport of a wide variety of different compounds, like sugars...; Region: ABC_NrtD_SsuB_transporters; cd03293 114615001405 Walker A/P-loop; other site 114615001406 ATP binding site [chemical binding]; other site 114615001407 Q-loop/lid; other site 114615001408 ABC transporter signature motif; other site 114615001409 Walker B; other site 114615001410 D-loop; other site 114615001411 H-loop/switch region; other site 114615001412 OsmC-like protein; Region: OsmC; cl00767 114615001413 NlpC/P60 family; Region: NLPC_P60; cl11438 114615001414 DNA mismatch repair protein MutS; Provisional; Region: PRK05399 114615001415 MutS domain I; Region: MutS_I; pfam01624 114615001416 MutS domain II; Region: MutS_II; pfam05188 114615001417 MutS family domain IV; Region: MutS_IV; pfam05190 114615001418 MutS1 homolog in eukaryotes. The MutS protein initiates DNA mismatch repair by recognizing mispaired and unpaired bases embedded in duplex DNA and activating endo- and exonucleases to remove the mismatch. Members of the MutS family possess C-terminal...; Region: ABC_MutS1; cd03284 114615001419 Walker A/P-loop; other site 114615001420 ATP binding site [chemical binding]; other site 114615001421 Q-loop/lid; other site 114615001422 ABC transporter signature motif; other site 114615001423 Walker B; other site 114615001424 D-loop; other site 114615001425 H-loop/switch region; other site 114615001426 beta-ketoadipyl CoA thiolase; Validated; Region: PRK09050 114615001427 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 114615001428 dimer interface [polypeptide binding]; other site 114615001429 active site 114615001430 Intradiol dioxygenases catalyze the critical ring-cleavage step in the conversion of catecholate derivatives to citric acid cycle intermediates. This family contains catechol 1,2-dioxygenases and protocatechuate 3,4-dioxygenases which are mononuclear...; Region: intradiol_dioxygenase; cl01383 114615001431 chlorocatechol 1,2-dioxygenase; Region: chlorocat_1_2; TIGR02465 114615001432 Active site [active] 114615001433 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 114615001434 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 114615001435 putative substrate translocation pore; other site 114615001436 Multidrug resistance efflux pump [Defense mechanisms]; Region: EmrA; COG1566 114615001437 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase...; Region: biotinyl_domain; cd06850 114615001438 Transcriptional regulators [Transcription]; Region: MarR; COG1846 114615001439 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 114615001440 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 114615001441 metal binding site 2 [ion binding]; metal-binding site 114615001442 putative DNA binding helix; other site 114615001443 metal binding site 1 [ion binding]; metal-binding site 114615001444 dimer interface [polypeptide binding]; other site 114615001445 structural Zn2+ binding site [ion binding]; other site 114615001446 EamA-like transporter family; Region: EamA; cl01037 114615001447 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 114615001448 EamA-like transporter family; Region: EamA; cl01037 114615001449 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Reviewed; Region: ispG; PRK00366 114615001450 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate synthase; Region: ispG_gcpE; TIGR00612 114615001451 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 114615001452 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 114615001453 Plasmid stabilisation system protein; Region: Plasmid_stabil; cl11422 114615001454 Na+/H+ antiporter, bacterial form; Region: a_cpa1; TIGR00831 114615001455 Putative lumazine-binding; Region: Lumazine_bd_2; pfam12893 114615001456 Caspase, interleukin-1 beta converting enzyme (ICE) homologues; Cysteine-dependent aspartate-directed proteases that mediate programmed cell death (apoptosis). Caspases are synthesized as inactive zymogens and activated by proteolysis of the peptide...; Region: CASc; cl00042 114615001457 Protein of unknown function (DUF1345); Region: DUF1345; cl01753 114615001458 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 114615001459 substrate binding pocket [chemical binding]; other site 114615001460 chain length determination region; other site 114615001461 substrate-Mg2+ binding site; other site 114615001462 catalytic residues [active] 114615001463 aspartate-rich region 1; other site 114615001464 active site lid residues [active] 114615001465 aspartate-rich region 2; other site 114615001466 Transglycosylase; Region: Transgly; cl07896 114615001467 Ribosomal L32p protein family; Region: Ribosomal_L32p; cl09115 114615001468 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 114615001469 metal binding site [ion binding]; metal-binding site 114615001470 active site 114615001471 I-site; other site 114615001472 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 114615001473 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5394 114615001474 PHB/PHA accumulation regulator DNA-binding domain; Region: PHB_acc_N; pfam07879 114615001475 PHB accumulation regulatory domain; Region: PHB_acc; pfam05233 114615001476 putative acyltransferase; Provisional; Region: PRK05790 114615001477 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 114615001478 dimer interface [polypeptide binding]; other site 114615001479 active site 114615001480 acetoacetyl-CoA reductase; Region: AcAcCoA_reduct; TIGR01829 114615001481 beta-Keto acyl carrier protein reductase (BKR), involved in Type II FAS, classical (c) SDRs; Region: BKR_SDR_c; cd05333 114615001482 NAD(P) binding site [chemical binding]; other site 114615001483 homotetramer interface [polypeptide binding]; other site 114615001484 homodimer interface [polypeptide binding]; other site 114615001485 active site 114615001486 aromatic amino acid exporter; Provisional; Region: PRK11689 114615001487 EamA-like transporter family; Region: EamA; cl01037 114615001488 Predicted signal transduction protein containing a membrane domain, an EAL and a GGDEF domain [Signal transduction mechanisms]; Region: COG5001 114615001489 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 114615001490 metal binding site [ion binding]; metal-binding site 114615001491 active site 114615001492 I-site; other site 114615001493 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 114615001494 Cupin superfamily (DUF985); Region: Cupin_5; cl01418 114615001495 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 114615001496 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cl12011 114615001497 DREV methyltransferase; Region: DREV; pfam05219 114615001498 N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase; Provisional; Region: PRK09328 114615001499 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cl12011 114615001500 peptide chain release factor 2; Provisional; Region: PRK06746 114615001501 RF-1 domain; Region: RF-1; cl02875 114615001502 RF-1 domain; Region: RF-1; cl02875 114615001503 Signal transduction protein containing GAF and PtsI domains [Signal transduction mechanisms]; Region: PtsP; COG3605 114615001504 GAF domain; Region: GAF; cl00853 114615001505 PEP-utilising enzyme, N-terminal; Region: PEP-utilisers_N; pfam05524 114615001506 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; cl01586 114615001507 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl09155 114615001508 aspartate kinase; Reviewed; Region: PRK06635 114615001509 AAK_AKii-LysC-BS: Amino Acid Kinase Superfamily (AAK), AKii; this CD includes the N-terminal catalytic aspartokinase (AK) domain of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis 168, and the lysine plus threonine-sensitive...; Region: AAK_AKii-LysC-BS; cd04261 114615001510 putative nucleotide binding site [chemical binding]; other site 114615001511 putative catalytic residues [active] 114615001512 putative Mg ion binding site [ion binding]; other site 114615001513 putative aspartate binding site [chemical binding]; other site 114615001514 ACT domains of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related proteins; Region: ACT_AKii-LysC-BS-like_1; cd04913 114615001515 putative allosteric regulatory site; other site 114615001516 ACT domains of the lysine-sensitive, aspartokinase (AK) isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related domains; Region: ACT_AKii-LysC-BS-like_2; cd04936 114615001517 putative allosteric regulatory residue; other site 114615001518 Bacterial membrane flanked domain; Region: DUF304; cl01348 114615001519 bifunctional 3-demethylubiquinone-9 3-methyltransferase/ 2-octaprenyl-6-hydroxy phenol methylase; Provisional; Region: PRK05134 114615001520 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cd02440 114615001521 S-adenosylmethionine binding site [chemical binding]; other site 114615001522 GIY-YIG domain of uncharacterized hypothetical protein found in bacteria; Region: GIY-YIG_unchar_3; cd10448 114615001523 GIY-YIG motif/motif A; other site 114615001524 putative active site [active] 114615001525 putative metal binding site [ion binding]; other site 114615001526 EamA-like transporter family; Region: EamA; cl01037 114615001527 Zinc ribbon domain; Region: CxxC_CxxC_SSSS; cl00993 114615001528 Predicted amidohydrolase [General function prediction only]; Region: COG0388 114615001529 Nit1, Nit 2, and related proteins, and the Nit1-like domain of NitFhit (class 10 nitrilases); Region: nit; cd07572 114615001530 putative active site [active] 114615001531 catalytic triad [active] 114615001532 dimer interface [polypeptide binding]; other site 114615001533 Glutaredoxin (GRX) family, GRX bacterial class 1 and 3 (b_1_3)-like subfamily; composed of bacterial GRXs, approximately 10 kDa in size, and proteins containing a GRX or GRX-like domain. GRX is a glutathione (GSH) dependent reductase, catalyzing the...; Region: GRX_GRXb_1_3_like; cd03418 114615001534 GSH binding site [chemical binding]; other site 114615001535 catalytic residues [active] 114615001536 Predicted amidophosphoribosyltransferases [General function prediction only]; Region: ComFC; COG1040 114615001537 Phosphoribosyl transferase domain; Region: Pribosyltran; cl00309 114615001538 biotin biosynthesis protein BioC; Region: BioC; TIGR02072 114615001539 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cl12011 114615001540 The MutT pyrophosphohydrolase is a prototypical Nudix hydrolase that catalyzes the hydrolysis of nucleoside and deoxynucleoside triphosphates (NTPs and dNTPs) by substitution at a beta-phosphorus to yield a nucleotide monophosphate (NMP) and inorganic...; Region: MutT_pyrophosphohydrolase; cd03425 114615001541 active site 114615001542 8-oxo-dGMP binding site [chemical binding]; other site 114615001543 nudix motif; other site 114615001544 metal binding site [ion binding]; metal-binding site 114615001545 Flp pilus assembly protein TadG [Intracellular trafficking and secretion]; Region: TadG; COG4961 114615001546 Predicted membrane protein (DUF2134); Region: DUF2134; pfam09977 114615001547 Ornithine acetyltransferase (OAT) family; also referred to as ArgJ. OAT catalyzes the first and fifth steps in arginine biosynthesis, coupling acetylation of glutamate with deacetylation of N-acetylornithine, which allows recycling of the acetyl group...; Region: OAT; cd02152 114615001548 heterotetramer interface [polypeptide binding]; other site 114615001549 active site pocket [active] 114615001550 cleavage site 114615001551 peptidylprolyl isomerase; Reviewed; Region: prsA; PRK03002 114615001552 PPIC-type PPIASE domain; Region: Rotamase; cl08278 114615001553 preprotein translocase subunit SecA; Reviewed; Region: PRK12904 114615001554 SecA preprotein cross-linking domain; Region: SecA_PP_bind; cl03078 114615001555 hypothetical protein; Provisional; Region: PRK10396 114615001556 SEC-C motif; Region: SEC-C; cl12132 114615001557 Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; cl07971 114615001558 hypothetical protein; Provisional; Region: PRK07538 114615001559 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 114615001560 AMP-binding domain protein; Validated; Region: PRK07529 114615001561 Acyl-protein synthetase, LuxE; Region: LuxE; cl10450 114615001562 Transposase domain (DUF772); Region: DUF772; cl12084 114615001563 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 114615001564 Transcriptional regulators [Transcription]; Region: MarR; COG1846 114615001565 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 114615001566 Type I periplasmic-binding protein of the nitrile hydratase (NHase) system that selectively converts nitriles to corresponding amides; Region: PBP1_NHase; cd06358 114615001567 putative ligand binding site [chemical binding]; other site 114615001568 MHYT domain (predicted integral membrane sensor domain) [Signal transduction mechanisms]; Region: COG3300 114615001569 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 114615001570 metal binding site [ion binding]; metal-binding site 114615001571 active site 114615001572 I-site; other site 114615001573 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 114615001574 membrane-bound PQQ-dependent dehydrogenase, glucose/quinate/shikimate family; Region: PQQ_membr_DH; TIGR03074 114615001575 Dehydrogenases with pyrrolo-quinoline quinone (PQQ) as cofactor, like ethanol, methanol, and membrane bound glucose dehydrogenases. The alignment model contains an 8-bladed beta-propeller; Region: PQQ_DH; cl11493 114615001576 Trp docking motif; other site 114615001577 active site 114615001578 Dehydrogenases with pyrrolo-quinoline quinone (PQQ) as cofactor, like ethanol, methanol, and membrane bound glucose dehydrogenases. The alignment model contains an 8-bladed beta-propeller; Region: PQQ_DH; cl11493 114615001579 Trp docking motif; other site 114615001580 active site 114615001581 'Velcro' closure; other site 114615001582 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3034 114615001583 alpha-ketoglutarate decarboxylase; Reviewed; Region: kgd; PRK12270 114615001584 Acetyl co-enzyme A carboxylase carboxyltransferase alpha subunit; Region: ACCA; cl00513 114615001585 tyrosine recombinase XerD; Region: recomb_XerD; TIGR02225 114615001586 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 114615001587 DNA binding site [nucleotide binding] 114615001588 Int/Topo IB signature motif; other site 114615001589 active site 114615001590 shikimate kinase; Reviewed; Region: aroK; PRK00131 114615001591 Shikimate kinase (SK) is the fifth enzyme in the shikimate pathway, a seven-step biosynthetic pathway which converts erythrose-4-phosphate to chorismic acid, found in bacteria, fungi and plants. Chorismic acid is a important intermediate in the...; Region: SK; cd00464 114615001592 ADP binding site [chemical binding]; other site 114615001593 magnesium binding site [ion binding]; other site 114615001594 putative shikimate binding site; other site 114615001595 Dehydroquinate synthase (DHQS) catalyzes the conversion of DAHP to DHQ in shikimate pathway for aromatic compounds synthesis; Region: DHQS; cd08195 114615001596 Iron-containing alcohol dehydrogenase; Region: Fe-ADH; pfam00465 114615001597 active site 114615001598 dimer interface [polypeptide binding]; other site 114615001599 metal binding site [ion binding]; metal-binding site 114615001600 Putative Mg2+ and Co2+ transporter CorB [Inorganic ion transport and metabolism]; Region: CorB; COG4536 114615001601 Domain of unknown function DUF21; Region: DUF21; pfam01595 114615001602 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 114615001603 Transporter associated domain; Region: CorC_HlyC; cl08393 114615001604 BolA-like protein; Region: BolA; cl00386 114615001605 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of...; Region: DnaJ; cd06257 114615001606 HSP70 interaction site [polypeptide binding]; other site 114615001607 Bacillus subtilis (Bs) citrate synthase CS-I_like. CS catalyzes the condensation of acetyl coenzyme A (AcCoA) and oxalacetate (OAA) to form citrate and coenzyme A (CoA), the first step in the citric acid cycle (TCA or Krebs cycle). 2MCS catalyzes the...; Region: BsCS-I_like; cd06109 114615001608 dimer interface [polypeptide binding]; other site 114615001609 Citrate synthase; Region: Citrate_synt; pfam00285 114615001610 active site 114615001611 citrylCoA binding site [chemical binding]; other site 114615001612 oxalacetate/citrate binding site [chemical binding]; other site 114615001613 coenzyme A binding site [chemical binding]; other site 114615001614 catalytic triad [active] 114615001615 Citrate synthase (CS) catalyzes the condensation of acetyl coenzyme A (AcCoA) and oxalacetate (OAA) to form citrate and coenzyme A (CoA), the first step in the oxidative citric acid cycle (TCA or Krebs cycle). Peroxisomal CS is involved in the...; Region: citrate_synt_like_2; cd06102 114615001616 dimer interface [polypeptide binding]; other site 114615001617 Citrate synthase; Region: Citrate_synt; pfam00285 114615001618 active site 114615001619 oxalacetate/citrate binding site [chemical binding]; other site 114615001620 citrylCoA binding site [chemical binding]; other site 114615001621 coenzyme A binding site [chemical binding]; other site 114615001622 catalytic triad [active] 114615001623 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 114615001624 SNARE associated Golgi protein; Region: SNARE_assoc; cl00429 114615001625 cobaltochelatase, CobS subunit; Region: PD_CobS; TIGR01650 114615001626 Cobaltochelatase CobS subunit N terminal; Region: CobS_N; pfam12556 114615001627 Ras-like GTPase superfamily. The Ras-like superfamily of small GTPases consists of several families with an extremely high degree of structural and functional similarity. The Ras superfamily is divided into at least four families in eukaryotes: the Ras...; Region: Ras_like_GTPase; cl10444 114615001628 Cobalamin biosynthesis protein CobT; Region: CobT; pfam06213 114615001629 cobaltochelatase, CobT subunit; Region: CobT; TIGR01651 114615001630 norD type: Denitrifying bacteria contain both membrane bound and periplasmic nitrate reductases. Denitrification plays a major role in completing the nitrogen cycle by converting nitrate or nitrite to nitrogen gas. The pathway for microbial...; Region: vWA_norD_type; cd01454 114615001631 metal ion-dependent adhesion site (MIDAS); other site 114615001632 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4246 114615001633 NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902 114615001634 Old yellow enzyme (OYE) YqjM-like FMN binding domain. YqjM is involved in the oxidative stress response of Bacillus subtilis. Like the other OYE members, each monomer of YqjM contains FMN as a non-covalently bound cofactor and uses NADPH as a reducing...; Region: OYE_YqiM_FMN; cd02932 114615001635 active site 114615001636 FMN binding site [chemical binding]; other site 114615001637 substrate binding site [chemical binding]; other site 114615001638 homotetramer interface [polypeptide binding]; other site 114615001639 catalytic residue [active] 114615001640 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 114615001641 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases [Energy production and conversion]; Region: COG2141 114615001642 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_13; cd08517 114615001643 Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496 114615001644 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 114615001645 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261 114615001646 dimer interface [polypeptide binding]; other site 114615001647 conserved gate region; other site 114615001648 putative PBP binding loops; other site 114615001649 ABC-ATPase subunit interface; other site 114615001650 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261 114615001651 dimer interface [polypeptide binding]; other site 114615001652 conserved gate region; other site 114615001653 putative PBP binding loops; other site 114615001654 ABC-ATPase subunit interface; other site 114615001655 ATPase components of various ABC-type transport systems, contain duplicated ATPase [General function prediction only]; Region: COG1123 114615001656 The ABC transporter subfamily specific for the transport of dipeptides, oligopeptides (OppD), and nickel (NikDE). The NikABCDE system of E. coli belongs to this family and is composed of the periplasmic binding protein NikA, two integral membrane...; Region: ABC_NikE_OppD_transporters; cd03257 114615001657 Walker A/P-loop; other site 114615001658 ATP binding site [chemical binding]; other site 114615001659 Q-loop/lid; other site 114615001660 ABC transporter signature motif; other site 114615001661 Walker B; other site 114615001662 D-loop; other site 114615001663 H-loop/switch region; other site 114615001664 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 114615001665 The ABC transporter subfamily specific for the transport of dipeptides, oligopeptides (OppD), and nickel (NikDE). The NikABCDE system of E. coli belongs to this family and is composed of the periplasmic binding protein NikA, two integral membrane...; Region: ABC_NikE_OppD_transporters; cd03257 114615001666 Walker A/P-loop; other site 114615001667 ATP binding site [chemical binding]; other site 114615001668 Q-loop/lid; other site 114615001669 ABC transporter signature motif; other site 114615001670 Walker B; other site 114615001671 D-loop; other site 114615001672 H-loop/switch region; other site 114615001673 Ribosomal protein S21; Region: Ribosomal_S21; cl00529 114615001674 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box protein...; Region: CSP_CDS; cd04458 114615001675 DNA-binding site [nucleotide binding]; DNA binding site 114615001676 RNA-binding motif; other site 114615001677 Uncharacterized conserved protein (DUF2235); Region: DUF2235; cl01480 114615001678 Ribosomal L28 family; Region: Ribosomal_L28; cl00367 114615001679 Protein of unknown function (DUF3108); Region: DUF3108; pfam11306 114615001680 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 114615001681 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 114615001682 nucleotide binding region [chemical binding]; other site 114615001683 ATP-binding site [chemical binding]; other site 114615001684 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cl09940 114615001685 Domain of unknown function (DUF3470); Region: DUF3470; pfam11953 114615001686 CarD-like/TRCF domain; Region: CarD_TRCF; cl00588 114615001687 Putative Zn-dependent protease [General function prediction only]; Region: COG4784 114615001688 Peptidase family M48; Region: Peptidase_M48; cl12018 114615001689 Staphylococcal nuclease homologues. SNase homologues are found in bacteria, archaea, and eukaryotes. They contain no disufide bonds; Region: SNc; cl00140 114615001690 ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683 114615001691 Periplasmic solute-binding domain of active transport proteins that belong to the type I periplasmic binding fold protein family; Region: PBP1_SBP_like_1; cd06327 114615001692 putative ligand binding site [chemical binding]; other site 114615001693 enoyl-CoA hydratase; Provisional; Region: PRK06688 114615001694 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase...; Region: crotonase-like; cd06558 114615001695 substrate binding site [chemical binding]; other site 114615001696 oxyanion hole (OAH) forming residues; other site 114615001697 trimer interface [polypeptide binding]; other site 114615001698 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 114615001699 active site 114615001700 metal binding site [ion binding]; metal-binding site 114615001701 TIR domain; Region: TIR; cl02060 114615001702 CHAT domain; Region: CHAT; cl02083 114615001703 Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024 114615001704 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase...; Region: crotonase-like; cd06558 114615001705 substrate binding site [chemical binding]; other site 114615001706 oxyanion hole (OAH) forming residues; other site 114615001707 trimer interface [polypeptide binding]; other site 114615001708 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 114615001709 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 114615001710 active site 114615001711 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 114615001712 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 114615001713 classical (c) SDRs; Region: SDR_c; cd05233 114615001714 NAD(P) binding site [chemical binding]; other site 114615001715 active site 114615001716 Transglycosylase associated protein; Region: Transgly_assoc; cl00978 114615001717 Bacterial protein of unknown function (DUF937); Region: DUF937; cl01528 114615001718 Phytoene dehydrogenase and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG1233 114615001719 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 114615001720 M28 Zn-Peptidases; Region: M28_like_6; cd08656 114615001721 metal binding site [ion binding]; metal-binding site 114615001722 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cd02440 114615001723 S-adenosylmethionine binding site [chemical binding]; other site 114615001724 Flavin Reductases; Region: FlaRed; cl00801 114615001725 PAP2_like proteins, a super-family of histidine phosphatases and vanadium haloperoxidases, includes type 2 phosphatidic acid phosphatase or lipid phosphate phosphatase (LPP), Glucose-6-phosphatase, Phosphatidylglycerophosphatase B and bacterial acid...; Region: PAP2_like; cl00474 114615001726 active site 114615001727 Uncharacterized protein with a C-terminal OMP (outer membrane protein) domain [Function unknown]; Region: COG4625 114615001728 Autotransporter beta-domain; Region: Autotransporter; cl02365 114615001729 putative PEP-CTERM system TPR-repeat lipoprotein; Region: PEP_TPR_lipo; TIGR02917 114615001730 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi...; Region: TPR; cd00189 114615001731 binding surface 114615001732 TPR motif; other site 114615001733 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi...; Region: TPR; cd00189 114615001734 binding surface 114615001735 TPR motif; other site 114615001736 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 114615001737 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 114615001738 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases [Energy production and conversion]; Region: COG2141 114615001739 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 114615001740 Homoserine acetyltransferase [Amino acid transport and metabolism]; Region: MET2; COG2021 114615001741 This CD includes the putative hydrocarbon oxygenase, MocD, a bacterial rhizopine (3-O-methyl-scyllo-inosamine, 3-O-MSI) oxygenase, and other related proteins. It has been proposed that MocD, MocE (Rieske-like ferredoxin), and MocF (ferredoxin reductase); Region: Rhizopine-oxygenase-like; cd03511 114615001742 Fatty acid desaturase; Region: FA_desaturase; pfam00487 114615001743 putative di-iron ligands [ion binding]; other site 114615001744 Superfamily I DNA and RNA helicases [DNA replication, recombination, and repair]; Region: UvrD; COG0210 114615001745 UvrD/REP helicase; Region: UvrD-helicase; cl14126 114615001746 Transcriptional accessory protein [Transcription]; Region: Tex; COG2183 114615001747 Tex-like protein N-terminal domain; Region: Tex_N; pfam09371 114615001748 Holliday junction resolvases (HJRs) are endonucleases that specifically resolve Holliday junction DNA intermediates during homologous recombination. HJR's occur in archaea, bacteria, and in the mitochondria of certain fungi, however this CD includes...; Region: RuvC_resolvase; cl00243 114615001749 S1_Tex: The C-terminal S1 domain of a transcription accessory factor called Tex, which has been characterized in Bordetella pertussis and Pseudomonas aeruginosa. The tex gene is essential in Bortella pertusis and is named for its role in toxin...; Region: S1_Tex; cd05685 114615001750 RNA binding site [nucleotide binding]; other site 114615001751 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 114615001752 NAD(P) binding site [chemical binding]; other site 114615001753 active site 114615001754 tryptophan tryptophylquinone biosynthesis enzyme MauG; Region: TTQ_mauG; TIGR03791 114615001755 Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; cl11412 114615001756 Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices connected by an extended linker. The...; Region: HAMP; cl01054 114615001757 Taxis toward Aspartate and Related amino acids and Homologs (TarH). The Tar chemoreceptor of Escherichia coli mediates attractant responses to aspartate, maltose, and phenol, repellent responses to Ni2+ and Co2+, and thermoresponses. These...; Region: TarH; cl00144 114615001758 Bacterial extracellular solute-binding protein, family 7; Region: SBP_bac_7; cl00710 114615001759 Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices connected by an extended linker. The...; Region: HAMP; cl01054 114615001760 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 114615001761 Taxis toward Aspartate and Related amino acids and Homologs (TarH). The Tar chemoreceptor of Escherichia coli mediates attractant responses to aspartate, maltose, and phenol, repellent responses to Ni2+ and Co2+, and thermoresponses. These...; Region: TarH; cl00144 114615001762 Predicted hydrolase of the alpha/beta-hydrolase fold [General function prediction only]; Region: COG3571 114615001763 Tripartite tricarboxylate transporter family receptor; Region: TctC; cl15260 114615001764 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 114615001765 NrtD and SsuB are the ATP-binding subunits of the bacterial ABC-type nitrate and sulfonate transport systems, respectively. ABC transporters are a large family of proteins involved in the transport of a wide variety of different compounds, like sugars...; Region: ABC_NrtD_SsuB_transporters; cd03293 114615001766 Walker A/P-loop; other site 114615001767 ATP binding site [chemical binding]; other site 114615001768 Q-loop/lid; other site 114615001769 ABC transporter signature motif; other site 114615001770 Walker B; other site 114615001771 D-loop; other site 114615001772 H-loop/switch region; other site 114615001773 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 114615001774 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cl00427 114615001775 gentisate 1,2-dioxygenase; Region: gentisate_1_2; TIGR02272 114615001776 Cupin domain; Region: Cupin_2; cl09118 114615001777 Cupin domain; Region: Cupin_2; cl09118 114615001778 GST_N family, Class Zeta subfamily; GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of endogenous and xenobiotic alkylating agents, including carcinogens...; Region: GST_N_Zeta; cd03042 114615001779 maleylacetoacetate isomerase; Region: maiA; TIGR01262 114615001780 C-terminal domain interface [polypeptide binding]; other site 114615001781 GSH binding site (G-site) [chemical binding]; other site 114615001782 putative dimer interface [polypeptide binding]; other site 114615001783 C-terminal, alpha helical domain of Class Zeta Glutathione S-transferases; Region: GST_C_Zeta; cd03191 114615001784 dimer interface [polypeptide binding]; other site 114615001785 N-terminal domain interface [polypeptide binding]; other site 114615001786 maleylacetoacetate (MAA) substrate binding site (H site) [chemical binding]; other site 114615001787 Transcriptional regulators [Transcription]; Region: MarR; COG1846 114615001788 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 114615001789 benzoate-CoA ligase family; Region: benz_CoA_lig; TIGR02262 114615001790 Acyl-protein synthetase, LuxE; Region: LuxE; cl10450 114615001791 salicylyl-CoA 5-hydroxylase; Reviewed; Region: PRK08255 114615001792 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 114615001793 Sodium:dicarboxylate symporter family; Region: SDF; cl00573 114615001794 glutamate and aspartate transporter subunit; Provisional; Region: PRK10797 114615001795 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and...; Region: PBPb; cd00134 114615001796 substrate binding pocket [chemical binding]; other site 114615001797 membrane-bound complex binding site; other site 114615001798 hinge residues; other site 114615001799 cyanophycin synthetase; Region: cya_phycin_syn; TIGR02068 114615001800 Flavodoxin reductases (ferredoxin-NADPH reductases) family 1 [Energy production and conversion]; Region: Hmp; COG1018 114615001801 Ferredoxin-NADP+ (oxido)reductase is an FAD-containing enzyme that catalyzes the reversible electron transfer between NADP(H) and electron carrier proteins such as ferredoxin and flavodoxin. Isoforms of these flavoproteins (i.e. having a non-covalently...; Region: FNR1; cd06195 114615001802 FAD binding pocket [chemical binding]; other site 114615001803 FAD binding motif [chemical binding]; other site 114615001804 phosphate binding motif [ion binding]; other site 114615001805 beta-alpha-beta structure motif; other site 114615001806 NAD binding pocket [chemical binding]; other site 114615001807 acyl-CoA synthetase; Validated; Region: PRK08316 114615001808 Acyl-protein synthetase, LuxE; Region: LuxE; cl10450 114615001809 Glutamate synthase (GltS) FMN-binding domain. GltS is a complex iron-sulfur flavoprotein that catalyzes the reductive synthesis of L-glutamate from 2-oxoglutarate and L-glutamine via intramolecular channelling of ammonia, a reaction in the plant...; Region: GltS_FMN; cd02808 114615001810 active site 114615001811 FMN binding site [chemical binding]; other site 114615001812 substrate binding site [chemical binding]; other site 114615001813 3Fe-4S cluster binding site [ion binding]; other site 114615001814 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 114615001815 NrtD and SsuB are the ATP-binding subunits of the bacterial ABC-type nitrate and sulfonate transport systems, respectively. ABC transporters are a large family of proteins involved in the transport of a wide variety of different compounds, like sugars...; Region: ABC_NrtD_SsuB_transporters; cd03293 114615001816 Walker A/P-loop; other site 114615001817 ATP binding site [chemical binding]; other site 114615001818 Q-loop/lid; other site 114615001819 ABC transporter signature motif; other site 114615001820 Walker B; other site 114615001821 D-loop; other site 114615001822 H-loop/switch region; other site 114615001823 Uncharacterized conserved protein [Function unknown]; Region: COG4754 114615001824 ABC nitrate/sulfonate/bicarbonate family transporter, ATPase subunit; Region: ABC_transp; pfam09821 114615001825 ABC-type anion transport system, duplicated permease component [Inorganic ion transport and metabolism]; Region: COG4986 114615001826 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261 114615001827 dimer interface [polypeptide binding]; other site 114615001828 conserved gate region; other site 114615001829 putative PBP binding loops; other site 114615001830 ABC-ATPase subunit interface; other site 114615001831 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cl00427 114615001832 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 114615001833 Domain of unknown function DUF21; Region: DUF21; pfam01595 114615001834 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 114615001835 Transporter associated domain; Region: CorC_HlyC; cl08393 114615001836 Surface antigen; Region: Surface_Ag_2; cl01155 114615001837 Carbohydrate-selective porin, OprB family; Region: OprB; pfam04966 114615001838 Carbohydrate-selective porin [Cell envelope biogenesis, outer membrane]; Region: OprB; COG3659 114615001839 Creatinine amidohydrolase; Region: Creatininase; cl00618 114615001840 ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components [Inorganic ion transport and metabolism]; Region: TauA; COG0715 114615001841 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 114615001842 NrtD and SsuB are the ATP-binding subunits of the bacterial ABC-type nitrate and sulfonate transport systems, respectively. ABC transporters are a large family of proteins involved in the transport of a wide variety of different compounds, like sugars...; Region: ABC_NrtD_SsuB_transporters; cd03293 114615001843 Walker A/P-loop; other site 114615001844 ATP binding site [chemical binding]; other site 114615001845 Q-loop/lid; other site 114615001846 ABC transporter signature motif; other site 114615001847 Walker B; other site 114615001848 D-loop; other site 114615001849 H-loop/switch region; other site 114615001850 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 114615001851 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cl00427 114615001852 Lactate dehydrogenase and related dehydrogenases [Energy production and conversion / Coenzyme metabolism / General function prediction only]; Region: LdhA; COG1052 114615001853 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 114615001854 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459 114615001855 PAS fold; Region: PAS_7; pfam12860 114615001856 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459 114615001857 PAS fold; Region: PAS_4; pfam08448 114615001858 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 114615001859 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 114615001860 DNA-binding site [nucleotide binding]; DNA binding site 114615001861 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 114615001862 pyridoxal 5'-phosphate binding site [chemical binding]; other site 114615001863 homodimer interface [polypeptide binding]; other site 114615001864 catalytic residue [active] 114615001865 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 114615001866 EamA-like transporter family; Region: EamA; cl01037 114615001867 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 114615001868 ligand binding site [chemical binding]; other site 114615001869 flexible hinge region; other site 114615001870 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 114615001871 hypothetical protein; Reviewed; Region: PRK00024 114615001872 Dehydroquinate synthase-like (DHQ-like) and iron-containing alcohol dehydrogenases (Fe-ADH); Region: DHQ_Fe-ADH; cl02872 114615001873 Mov34/MPN/PAD-1 family; Region: MPN_DUF2466; cd08071 114615001874 MPN+ (JAMM) motif; other site 114615001875 Zinc-binding site [ion binding]; other site 114615001876 Bacterial transcriptional activator domain; Region: BTAD; smart01043 114615001877 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 114615001878 Isoprenylcysteine carboxyl methyltransferase (ICMT) family; Region: ICMT; cl00763 114615001879 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 114615001880 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 114615001881 putative substrate translocation pore; other site 114615001882 Intradiol dioxygenase supgroup. Intradiol dioxygenases catalyze the critical ring-cleavage step in the conversion of catecholate derivatives to citric acid cycle intermediates. They break the catechol C1-C2 bond and utilize Fe3+, as opposed to the...; Region: intradiol_dioxygenase_like; cd03457 114615001883 putative active site [active] 114615001884 Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086 114615001885 methionine aminopeptidase; Reviewed; Region: PRK07281 114615001886 active site 114615001887 Mechanosensitive ion channel; Region: MS_channel; pfam00924 114615001888 potassium/proton antiporter; Reviewed; Region: PRK05326 114615001889 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; cl10482 114615001890 Transporter associated domain; Region: CorC_HlyC; cl08393 114615001891 Plasmid stabilisation system protein; Region: Plasmid_stabil; cl11422 114615001892 Penicillin-insensitive murein endopeptidase; Region: Peptidase_M74; cl01538 114615001893 PAS fold; Region: PAS_7; pfam12860 114615001894 PAS domain S-box; Region: sensory_box; TIGR00229 114615001895 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459 114615001896 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 114615001897 metal binding site [ion binding]; metal-binding site 114615001898 active site 114615001899 I-site; other site 114615001900 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 114615001901 transcriptional activator FtrA; Provisional; Region: ftrA; PRK09393 114615001902 AraC transcriptional regulators having a Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GATase1_AraC_1; cd03137 114615001903 conserved cys residue [active] 114615001904 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 114615001905 Member of the Rhodanese Homology Domain superfamily. This CD includes the putative rhodanese-like protein, Psp2, of Yersinia pestis biovar Medievalis and other similar uncharacterized proteins; Region: RHOD_PspE2; cd01521 114615001906 active site residue [active] 114615001907 Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices connected by an extended linker. The...; Region: HAMP; cl01054 114615001908 Taxis toward Aspartate and Related amino acids and Homologs (TarH). The Tar chemoreceptor of Escherichia coli mediates attractant responses to aspartate, maltose, and phenol, repellent responses to Ni2+ and Co2+, and thermoresponses. These...; Region: TarH; cl00144 114615001909 GTP-binding protein LepA; Provisional; Region: PRK05433 114615001910 LepA subfamily. LepA belongs to the GTPase family of and exhibits significant homology to the translation factors EF-G and EF-Tu, indicating its possible involvement in translation and association with the ribosome. LepA is ubiquitous in bacteria and...; Region: LepA; cd01890 114615001911 G1 box; other site 114615001912 putative GEF interaction site [polypeptide binding]; other site 114615001913 GTP/Mg2+ binding site [chemical binding]; other site 114615001914 Switch I region; other site 114615001915 G2 box; other site 114615001916 G3 box; other site 114615001917 Switch II region; other site 114615001918 G4 box; other site 114615001919 G5 box; other site 114615001920 Translation_Factor_II_like: Elongation factor Tu (EF-Tu) domain II-like proteins. Elongation factor Tu consists of three structural domains, this family represents the second domain. Domain II adopts a beta barrel structure and is involved in binding...; Region: Translation_Factor_II_like; cl02787 114615001921 lepA_C: This family represents the C-terminal region of LepA, a GTP-binding protein localized in the cytoplasmic membrane. LepA is ubiquitous in Bacteria and Eukaryota (e.g. Saccharomyces cerevisiae GUF1p), but is missing from Archaea. LepA exhibits...; Region: lepA_C; cd03709 114615001922 GTP-binding protein LepA C-terminus; Region: LepA_C; pfam06421 114615001923 4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family [Cell envelope biogenesis, outer membrane]; Region: ArnT; COG1807 114615001924 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367 114615001925 dimerization domain swap beta strand [polypeptide binding]; other site 114615001926 regulatory protein interface [polypeptide binding]; other site 114615001927 active site 114615001928 regulatory phosphorylation site [posttranslational modification]; other site 114615001929 PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_man; cl00025 114615001930 active site 114615001931 HprK/P, the bifunctional histidine-containing protein kinase/phosphatase, controls the phosphorylation state of the phosphocarrier protein HPr and regulates the utilization of carbon sources by gram-positive bacteria. It catalyzes both the ATP-...; Region: HprK_C; cd01918 114615001932 Hpr binding site; other site 114615001933 active site 114615001934 homohexamer subunit interaction site [polypeptide binding]; other site 114615001935 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 114615001936 Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices connected by an extended linker. The...; Region: HAMP; cl01054 114615001937 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via trans-...; Region: HisKA; cd00082 114615001938 dimer interface [polypeptide binding]; other site 114615001939 phosphorylation site [posttranslational modification] 114615001940 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 114615001941 ATP binding site [chemical binding]; other site 114615001942 Mg2+ binding site [ion binding]; other site 114615001943 G-X-G motif; other site 114615001944 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 114615001945 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156 114615001946 active site 114615001947 phosphorylation site [posttranslational modification] 114615001948 intermolecular recognition site; other site 114615001949 dimerization interface [polypeptide binding]; other site 114615001950 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase...; Region: trans_reg_C; cd00383 114615001951 DNA binding site [nucleotide binding] 114615001952 Putative heme iron utilization protein [Inorganic ion transport and metabolism]; Region: HugZ; COG0748 114615001953 Pyridoxine 5'-phosphate (PNP) oxidase-like proteins; Region: PNPOx_like; cl00381 114615001954 Protein of unknown function (DUF2470); Region: DUF2470; pfam10615 114615001955 Phosphoenolpyruvate carboxykinase (PEPCK), a critical gluconeogenic enzyme, catalyzes the first committed step in the diversion of tricarboxylic acid cycle intermediates toward gluconeogenesis. It catalyzes the reversible decarboxylation and...; Region: PEPCK_ATP; cd00484 114615001956 active site 114615001957 substrate-binding site [chemical binding]; other site 114615001958 metal-binding site [ion binding] 114615001959 ATP binding site [chemical binding]; other site 114615001960 acyl-CoA thioesterase II; Region: tesB; TIGR00189 114615001961 This is a family of oligosaccharide phosphorylases. It includes yeast and mammalian glycogen phosphorylases, plant starch/glucan phosphorylase, as well as the maltodextrin phosphorylases of bacteria. The members of this family catalyze the breakdown of...; Region: GT1_Glycogen_Phosphorylase; cd04300 114615001962 homodimer interface [polypeptide binding]; other site 114615001963 glycogen/starch/alpha-glucan phosphorylases; Region: P_ylase; TIGR02093 114615001964 active site pocket [active] 114615001965 Protein of unknown function (DUF2865); Region: DUF2865; pfam11064 114615001966 Phosphoribosyl transferase domain; Region: Pribosyltran; cl00309 114615001967 GSH-dependent disulfide bond oxidoreductase; Provisional; Region: PRK13972 114615001968 GST_N family, Ure2p-like subfamily; composed of the Saccharomyces cerevisiae Ure2p and related GSTs. Ure2p is a regulator for nitrogen catabolism in yeast. It represses the expression of several gene products involved in the use of poor nitrogen...; Region: GST_N_Ure2p_like; cd03048 114615001969 C-terminal domain interface [polypeptide binding]; other site 114615001970 GSH binding site (G-site) [chemical binding]; other site 114615001971 dimer interface [polypeptide binding]; other site 114615001972 C-terminal, alpha helical domain of Escherichia coli YfcG Glutathione S-transferases and related uncharacterized proteins; Region: GST_C_YfcG_like; cd10291 114615001973 N-terminal domain interface [polypeptide binding]; other site 114615001974 putative dimer interface [polypeptide binding]; other site 114615001975 active site 114615001976 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 114615001977 ligand binding site [chemical binding]; other site 114615001978 Protein of unknown function (DUF2029); Region: DUF2029; cl09812 114615001979 5'-3' exonuclease; Region: 53EXOc; smart00475 114615001980 PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859 114615001981 active site 114615001982 metal binding site 1 [ion binding]; metal-binding site 114615001983 putative 5' ssDNA interaction site; other site 114615001984 metal binding site 3; metal-binding site 114615001985 metal binding site 2 [ion binding]; metal-binding site 114615001986 H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898 114615001987 putative DNA binding site [nucleotide binding]; other site 114615001988 putative metal binding site [ion binding]; other site 114615001989 DNA polymerase I - 3'-5' exonuclease and polymerase domains [DNA replication, recombination, and repair]; Region: PolA; COG0749 114615001990 DEDDy 3'-5' exonuclease domain of Escherichia coli DNA polymerase I and similar bacterial family-A DNA polymerases; Region: DNA_polA_I_Ecoli_like_exo; cd06139 114615001991 active site 114615001992 catalytic site [active] 114615001993 substrate binding site [chemical binding]; other site 114615001994 Polymerase I functions primarily to fill DNA gaps that arise during DNA repair, recombination and replication; Region: DNA_pol_A_pol_I_C; cd08637 114615001995 active site 114615001996 DNA binding site [nucleotide binding] 114615001997 catalytic site [active] 114615001998 Predicted O-acyltransferase [General function prediction only]; Region: COG3274; cl00792 114615001999 Predicted UDP-glucose 6-dehydrogenase [Cell envelope biogenesis, outer membrane]; Region: Ugd; COG1004 114615002000 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 114615002001 UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984 114615002002 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 114615002003 ATP-dependent helicase HrpB; Region: DEAH_box_HrpB; TIGR01970 114615002004 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 114615002005 ATP binding site [chemical binding]; other site 114615002006 putative Mg++ binding site [ion binding]; other site 114615002007 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 114615002008 ATP-dependent helicase C-terminal; Region: HrpB_C; pfam08482 114615002009 Bacterial aspartate proteases, retropepsin-like protease family; Region: retropepsin_like_bacteria; cd05483 114615002010 catalytic motif [active] 114615002011 Catalytic residue [active] 114615002012 Phosphomannomutase [Carbohydrate transport and metabolism]; Region: {ManB}; COG1109 114615002013 The phosphomannomutase/phosphoglucomutase (PMM/PGM) bifunctional enzyme catalyzes the reversible conversion of 1-phospho to 6-phospho-sugars (e.g. between mannose-1-phosphate and mannose-6-phosphate or glucose-1-phosphate and glucose-6-phosphate) via a...; Region: PMM_PGM; cd03089 114615002014 active site 114615002015 substrate binding site [chemical binding]; other site 114615002016 metal binding site [ion binding]; metal-binding site 114615002017 Taxis toward Aspartate and Related amino acids and Homologs (TarH). The Tar chemoreceptor of Escherichia coli mediates attractant responses to aspartate, maltose, and phenol, repellent responses to Ni2+ and Co2+, and thermoresponses. These...; Region: TarH; cl00144 114615002018 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 114615002019 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 114615002020 NTP pyrophosphohydrolases containing a Zn-finger, probably nucleic-acid-binding [DNA replication, recombination, and repair]; Region: NPY1; COG2816 114615002021 NADH pyrophosphatase-like rudimentary NUDIX domain; Region: NUDIX-like; pfam09296 114615002022 NADH pyrophosphatase zinc ribbon domain; Region: zf-NADH-PPase; pfam09297 114615002023 NADH pyrophosphatase, a member of the Nudix hydrolase superfamily, catalyzes the cleavage of NADH into reduced nicotinamide mononucleotide (NMNH) and AMP. Like other members of the Nudix family, it requires a divalent cation, such as Mg2+ or Mn2+, for...; Region: NADH_pyrophosphatase; cd03429 114615002024 putative NADH binding site [chemical binding]; other site 114615002025 putative active site [active] 114615002026 nudix motif; other site 114615002027 putative metal binding site [ion binding]; other site 114615002028 HIT family: HIT (Histidine triad) proteins, named for a motif related to the sequence HxHxH/Qxx (x, a hydrophobic amino acid), are a superfamily of nucleotide hydrolases and transferases, which act on the alpha-phosphate of ribonucleotides. On the...; Region: HIT_like; cl00228 114615002029 DNA polymerase III subunits gamma and tau; Validated; Region: PRK09111 114615002030 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes...; Region: AAA; cd00009 114615002031 Walker A motif; other site 114615002032 ATP binding site [chemical binding]; other site 114615002033 Walker B motif; other site 114615002034 arginine finger; other site 114615002035 DNA polymerase III subunits gamma and tau domain III; Region: DNA_pol3_gamma3; pfam12169 114615002036 DNA polymerase III gamma and tau subunits C terminal; Region: DUF3646; pfam12362 114615002037 Uncharacterised BCR, YbaB family COG0718; Region: DUF149; cl00494 114615002038 recombination protein RecR; Reviewed; Region: recR; PRK00076 114615002039 RecR protein; Region: RecR; pfam02132 114615002040 TOPRIM_recR: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in Escherichia coli RecR. RecR participates in the RecFOR pathway of homologous recombinational repair in prokaryotes. This pathway provides a...; Region: TOPRIM_recR; cd01025 114615002041 tetramer interface [polypeptide binding]; other site 114615002042 putative active site [active] 114615002043 putative metal-binding site [ion binding]; other site 114615002044 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cl11420 114615002045 muropeptide transporter; Reviewed; Region: ampG; PRK11902 114615002046 GIY-YIG domain of uncharacterized hypothetical protein found in bacteria; Region: GIY-YIG_unchar_3; cd10448 114615002047 GIY-YIG motif/motif A; other site 114615002048 putative active site [active] 114615002049 putative metal binding site [ion binding]; other site 114615002050 RmuC family; Region: RmuC; pfam02646 114615002051 Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(...; Region: Pep_deformylase; cd00487 114615002052 active site 114615002053 catalytic residues [active] 114615002054 metal binding site [ion binding]; metal-binding site 114615002055 methionyl-tRNA formyltransferase; Reviewed; Region: fmt; PRK00005 114615002056 Methionyl-tRNA formyltransferase, N-terminal hydrolase domain; Region: FMT_core_Met-tRNA-FMT_N; cd08646 114615002057 putative active site [active] 114615002058 substrate binding site [chemical binding]; other site 114615002059 putative cosubstrate binding site; other site 114615002060 catalytic site [active] 114615002061 C-terminal domain of Formyltransferase and other enzymes; Region: Met_tRNA_FMT_C; cd08704 114615002062 substrate binding site [chemical binding]; other site 114615002063 tRNA pseudouridine synthase A; Validated; Region: truA; PRK00021 114615002064 PseudoU_synth_EcTruA: Pseudouridine synthase, Escherichia coli TruA like. This group consists of eukaryotic and bacterial pseudouridine synthases similar to E. coli TruA, Pseudomonas aeruginosa truA and human pseudouridine synthase-like 1 (PUSL1)...; Region: PseudoU_synth_EcTruA; cd02570 114615002065 dimerization interface 3.5A [polypeptide binding]; other site 114615002066 active site 114615002067 Taxis toward Aspartate and Related amino acids and Homologs (TarH). The Tar chemoreceptor of Escherichia coli mediates attractant responses to aspartate, maltose, and phenol, repellent responses to Ni2+ and Co2+, and thermoresponses. These...; Region: TarH; cl00144 114615002068 succinyl-diaminopimelate desuccinylase; Reviewed; Region: PRK13009 114615002069 M20 Peptidase proteobacterial DapE encoded N-succinyl-L,L-diaminopimelic acid desuccinylase; Region: M20_DapE_proteobac; cd03891 114615002070 metal binding site [ion binding]; metal-binding site 114615002071 dimer interface [polypeptide binding]; other site 114615002072 2,3,4,5-tetrahydropyridine-2,6-carboxylate N-succinyltransferase; Provisional; Region: dapD; PRK11830 114615002073 2,3,4,5-tetrahydropyridine-2,6-dicarboxylate (THDP) N-succinyltransferase (also called THP succinyltransferase): THDP N-succinyltransferase catalyzes the conversion of tetrahydrodipicolinate and succinyl-CoA to N-succinyltetrahydrodipicolinate and CoA...; Region: LbH_THP_succinylT; cd03350 114615002074 trimer interface [polypeptide binding]; other site 114615002075 active site 114615002076 substrate binding site [chemical binding]; other site 114615002077 CoA binding site [chemical binding]; other site 114615002078 Predicted hydrolase (HAD superfamily) [General function prediction only]; Region: COG1011 114615002079 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others...; Region: HAD_like; cl11391 114615002080 Protein of unknown function (DUF1036); Region: DUF1036; cl02296 114615002081 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 114615002082 Protein of unknown function (DUF1036); Region: DUF1036; cl02296 114615002083 AAK_NAGK-C: N-Acetyl-L-glutamate kinase - cyclic (NAGK-C) catalyzes the phosphorylation of the gamma-COOH group of N-acetyl-L-glutamate (NAG) by ATP in the second step of arginine biosynthesis found in some bacteria and photosynthetic organisms using...; Region: AAK_NAGK-C; cd04250 114615002084 feedback inhibition sensing region; other site 114615002085 homohexameric interface [polypeptide binding]; other site 114615002086 nucleotide binding site [chemical binding]; other site 114615002087 N-acetyl-L-glutamate binding site [chemical binding]; other site 114615002088 Protein of unknown function (DUF423); Region: DUF423; cl01008 114615002089 The YihA (EngB) subfamily. This subfamily of GTPases is typified by the E. coli YihA, an essential protein involved in cell division control. YihA and its orthologs are small proteins that typically contain less than 200 amino acid residues and...; Region: YihA_EngB; cd01876 114615002090 G1 box; other site 114615002091 GTP/Mg2+ binding site [chemical binding]; other site 114615002092 Switch I region; other site 114615002093 G2 box; other site 114615002094 G3 box; other site 114615002095 Switch II region; other site 114615002096 G4 box; other site 114615002097 G5 box; other site 114615002098 membrane protein insertase; Provisional; Region: PRK01318 114615002099 60Kd inner membrane protein; Region: 60KD_IMP; cl00489 114615002100 Ribonuclease P; Region: Ribonuclease_P; cl00457 114615002101 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 114615002102 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 114615002103 ATP binding site [chemical binding]; other site 114615002104 Mg2+ binding site [ion binding]; other site 114615002105 G-X-G motif; other site 114615002106 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 114615002107 non-specific DNA binding site [nucleotide binding]; other site 114615002108 salt bridge; other site 114615002109 sequence-specific DNA binding site [nucleotide binding]; other site 114615002110 Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5- (beta-...; Region: TMP_TenI; cd00564 114615002111 pyrophosphate binding site [ion binding]; other site 114615002112 conjugal transfer relaxase TraA; Provisional; Region: PRK13889 114615002113 MobA/MobL family; Region: MobA_MobL; pfam03389 114615002114 Conjugal transfer protein TraD; Region: TraD; cl05753 114615002115 SIR2 superfamily of proteins includes silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein/histone deacetylation, where the acetyl group from the lysine epsilon-amino group is transferred to the ADP-ribose moiety of NAD+...; Region: SIR2; cl00195 114615002116 Piwi_piwi-like_ProArk: PIWI domain, Piwi-like subfamily found in Archaea and Bacteria. RNA silencing refers to a group of related gene-silencing mechanisms mediated by short RNA molecules, including siRNAs, miRNAs, and heterochromatin-related guide...; Region: Piwi_piwi-like_ProArk; cd04659 114615002117 5' RNA guide strand anchoring site; other site 114615002118 active site 114615002119 Peptidase S8 family domain, uncharacterized subfamily 12; Region: Peptidases_S8_12; cd07480 114615002120 active site 114615002121 catalytic triad [active] 114615002122 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 114615002123 Int/Topo IB signature motif; other site 114615002124 active site 114615002125 Histidinol-phosphate/aromatic aminotransferase and cobyric acid decarboxylase [Amino acid transport and metabolism]; Region: HisC; COG0079 114615002126 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 114615002127 pyridoxal 5'-phosphate binding site [chemical binding]; other site 114615002128 homodimer interface [polypeptide binding]; other site 114615002129 catalytic residue [active] 114615002130 chemotaxis-specific methylesterase; Provisional; Region: PRK00742 114615002131 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156 114615002132 active site 114615002133 phosphorylation site [posttranslational modification] 114615002134 intermolecular recognition site; other site 114615002135 dimerization interface [polypeptide binding]; other site 114615002136 CheB methylesterase; Region: CheB_methylest; pfam01339 114615002137 CheR methyltransferase, all-alpha domain; Region: CheR_N; pfam03705 114615002138 Methyltransferase, chemotaxis proteins; Region: MeTrc; smart00138 114615002139 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cl12011 114615002140 CheW, a small regulator protein, unique to the chemotaxis signalling in prokaryotes and archea. CheW interacts with the histidine kinase CheA, most likely with the related regulatory domain of CheA. CheW is proposed to form signalling arrays together...; Region: CheW; cd00732 114615002141 putative CheA interaction surface; other site 114615002142 Four helix bundle sensory module for signal transduction; Region: 4HB_MCP_2; pfam12729 114615002143 Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices connected by an extended linker. The...; Region: HAMP; cl01054 114615002144 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 114615002145 Taxis toward Aspartate and Related amino acids and Homologs (TarH). The Tar chemoreceptor of Escherichia coli mediates attractant responses to aspartate, maltose, and phenol, repellent responses to Ni2+ and Co2+, and thermoresponses. These...; Region: TarH; cl00144 114615002146 Four helix bundle sensory module for signal transduction; Region: 4HB_MCP_2; pfam12729 114615002147 Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices connected by an extended linker. The...; Region: HAMP; cl01054 114615002148 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 114615002149 Taxis toward Aspartate and Related amino acids and Homologs (TarH). The Tar chemoreceptor of Escherichia coli mediates attractant responses to aspartate, maltose, and phenol, repellent responses to Ni2+ and Co2+, and thermoresponses. These...; Region: TarH; cl00144 114615002150 CheW-like domain. CheW proteins are part of the chemotaxis signalling mechanism in bacteria. CheW interacts with the methyl accepting chemotaxis proteins (MCPs) and relays signals to CheY, which affects flageller rotation. This family includes CheW and...; Region: CheW_like; cl00256 114615002151 Chemotaxis protein histidine kinase and related kinases [Cell motility and secretion / Signal transduction mechanisms]; Region: CheA; COG0643 114615002152 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 114615002153 putative binding surface; other site 114615002154 active site 114615002155 Signal transducing histidine kinase, homodimeric domain; Region: H-kinase_dim; pfam02895 114615002156 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 114615002157 ATP binding site [chemical binding]; other site 114615002158 Mg2+ binding site [ion binding]; other site 114615002159 G-X-G motif; other site 114615002160 CheA regulatory domain; CheA is a histidine protein kinase present in bacteria and archea. Activated by the chemotaxis receptor a histidine phosphoryl group from CheA is passed directly to an aspartate in the response regulator CheY. This signalling...; Region: CheA_reg; cd00731 114615002161 Sulphate Transporter and Anti-Sigma factor antagonist domain found in the C-terminal region of sulphate transporters as well as in bacterial and archaeal proteins involved in the regulation of sigma factors; Region: STAS; cl00604 114615002162 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057 114615002163 metal ion-dependent adhesion site (MIDAS); other site 114615002164 Uncharacterized conserved protein [Function unknown]; Region: COG4278 114615002165 Peptidase family M48; Region: Peptidase_M48; cl12018 114615002166 VWA YIEM type: Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-...; Region: VWA_YIEM_type; cd01462 114615002167 metal ion-dependent adhesion site (MIDAS); other site 114615002168 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes...; Region: AAA; cd00009 114615002169 AAA domain (dynein-related subfamily); Region: AAA_5; pfam07728 114615002170 Walker A motif; other site 114615002171 ATP binding site [chemical binding]; other site 114615002172 AAA ATPase containing von Willebrand factor type A (vWA) domain [General function prediction only]; Region: MDN1; COG5271 114615002173 Walker B motif; other site 114615002174 arginine finger; other site 114615002175 SWIM zinc finger; Region: SWIM; cl11618 114615002176 4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family [Cell envelope biogenesis, outer membrane]; Region: ArnT; COG1807 114615002177 Tripartite tricarboxylate transporter family receptor; Region: TctC; cl15260 114615002178 Predicted oxidoreductases (related to aryl-alcohol dehydrogenases) [Energy production and conversion]; Region: Tas; COG0667 114615002179 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and...; Region: Aldo_ket_red; cd06660 114615002180 active site 114615002181 catalytic tetrad [active] 114615002182 hypothetical protein; Provisional; Region: PRK01254 114615002183 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster...; Region: Radical_SAM; cl15259 114615002184 Domain of unknown function (DUF3362); Region: DUF3362; pfam11842 114615002185 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others...; Region: HAD_like; cl11391 114615002186 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2268 114615002187 The band 7 domain of flotillin (reggie) like proteins. This group contains proteins similar to stomatin, prohibitin, flotillin, HlfK/C and podicin. Many of these band 7 domain-containing proteins are lipid raft-associated. Individual proteins of this...; Region: Band_7; cl02525 114615002188 Dienelactone hydrolase and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG0412 114615002189 GMP synthase - Glutamine amidotransferase domain [Nucleotide transport and metabolism]; Region: GuaA; COG0518 114615002190 Subgroup of proteins having the Type 1 glutamine amidotransferase (GATase1) domain; Region: GATase1_1; cd01741 114615002191 catalytic triad [active] 114615002192 LrgB-like family; Region: LrgB; cl00596 114615002193 LrgA family; Region: LrgA; cl00608 114615002194 DNA-binding transcriptional regulator CynR; Provisional; Region: PRK11242 114615002195 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 114615002196 The C-terminal substrate binding domain of LysR-like transcriptional regulator CidR, contains the type 2 periplasmic binding fold; Region: PBP2_CidR; cd08438 114615002197 putative dimerization interface [polypeptide binding]; other site 114615002198 TIGR03442 family protein; Region: TIGR03442 114615002199 Glutamine amidotransferases class-II (Gn-AT)_YafJ-type. YafJ is a glutamine amidotransferase-like protein of unknown function found in prokaryotes, eukaryotes and archaea. YafJ has a conserved structural fold similar to those of other class II...; Region: YafJ; cd01908 114615002200 putative active site [active] 114615002201 putative dimer interface [polypeptide binding]; other site 114615002202 asparagine synthase family amidotransferase; Region: trio_amidotrans; TIGR03104 114615002203 Glutamine amidotransferases class-II (GATase) asparagine synthase_B type. Asparagine synthetase B catalyses the ATP-dependent conversion of aspartate to asparagine. This enzyme is a homodimer, with each monomer composed of a glutaminase domain and a...; Region: AsnB; cd00712 114615002204 active site 114615002205 dimer interface [polypeptide binding]; other site 114615002206 The C-terminal domain of Asparagine Synthase B. This domain is always found associated n-terminal amidotransferase domain. Family members that contain this domain catalyse the conversion of aspartate to asparagine. Asparagine synthetase B catalyzes...; Region: Asn_Synthase_B_C; cd01991 114615002207 Ligand Binding Site [chemical binding]; other site 114615002208 Molecular Tunnel; other site 114615002209 Glutamate-cysteine ligase family 2(GCS2); Region: GCS2; cl00954 114615002210 carboxylate-amine ligase, YbdK family; Region: gshA_cyan_rel; TIGR02050 114615002211 cytosine deaminase; Provisional; Region: PRK05985 114615002212 Bacterial cytosine deaminase and related metal-dependent hydrolases. Cytosine deaminases (CDs) catalyze the deamination of cytosine, producing uracil and ammonia. They play an important role in pyrimidine salvage. CDs are present in prokaryotes and...; Region: Bact_CD; cd01293 114615002213 active site 114615002214 Predicted esterase [General function prediction only]; Region: COG0400 114615002215 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 114615002216 N-terminal domain of Sphingobium chlorophenolicum 2,6-dichloro-p-hydroquinone 1,2-dioxygenase (PcpA), and similar proteins; Region: PcpA_N_like; cd08346 114615002217 Zn binding site [ion binding]; other site 114615002218 C-terminal domain of Sphingobium chlorophenolicum 2,6-dichloro-p-hydroquinone 1,2-dioxygenase (PcpA), and similar proteins; Region: PcpA_C_like; cd08347 114615002219 Zn binding site [ion binding]; other site 114615002220 transcriptional regulator; Provisional; Region: PRK10632 114615002221 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 114615002222 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 114615002223 putative effector binding pocket; other site 114615002224 dimerization interface [polypeptide binding]; other site 114615002225 HIUase (5-hydroxyisourate hydrolase) catalyzes the second step in a three-step ureide pathway in which 5-hydroxyisourate (HIU), a product of the uricase (urate oxidase) reaction, is hydrolyzed to 2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline (OHCU)...; Region: TLP_HIUase; cd05822 114615002226 active site 114615002227 homotetramer interface [polypeptide binding]; other site 114615002228 putative urate catabolism protein; Region: uraD_N-term-dom; TIGR03212 114615002229 Polysaccharide deacetylase; Region: Polysacc_deac_1; cl12061 114615002230 OHCU decarboxylase; Region: OHCU_decarbox; cl01251 114615002231 Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154 114615002232 GGCT-like domains, also called AIG2-like family. Gamma-glutamyl cyclotransferase (GGCT) catalyzes the formation of pyroglutamic acid (5-oxoproline) from dipeptides containing gamma-glutamyl, and is a dimeric protein. In Homo sapiens, the protein is...; Region: GGCT_like; cl11426 114615002233 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 114615002234 putative substrate translocation pore; other site 114615002235 HIUase (5-hydroxyisourate hydrolase) catalyzes the second step in a three-step ureide pathway in which 5-hydroxyisourate (HIU), a product of the uricase (urate oxidase) reaction, is hydrolyzed to 2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline (OHCU)...; Region: TLP_HIUase; cd05822 114615002236 active site 114615002237 homotetramer interface [polypeptide binding]; other site 114615002238 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261 114615002239 dimer interface [polypeptide binding]; other site 114615002240 conserved gate region; other site 114615002241 putative PBP binding loops; other site 114615002242 ABC-ATPase subunit interface; other site 114615002243 2-aminoethylphosphonate transport system permease PhnU; Provisional; Region: PRK15050 114615002244 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261 114615002245 dimer interface [polypeptide binding]; other site 114615002246 conserved gate region; other site 114615002247 putative PBP binding loops; other site 114615002248 ABC-ATPase subunit interface; other site 114615002249 Spermidine/putrescine-binding periplasmic protein [Amino acid transport and metabolism]; Region: PotD; COG0687 114615002250 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 114615002251 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 114615002252 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 114615002253 Walker A/P-loop; other site 114615002254 ATP binding site [chemical binding]; other site 114615002255 Q-loop/lid; other site 114615002256 ABC transporter signature motif; other site 114615002257 Walker B; other site 114615002258 D-loop; other site 114615002259 H-loop/switch region; other site 114615002260 TOBE domain; Region: TOBE_2; cl01440 114615002261 Asp/Glu/Hydantoin racemase; Region: Asp_Glu_race; cl00518 114615002262 Protein of unknown function (DUF3429); Region: DUF3429; pfam11911 114615002263 Uncharacterized protein conserved in bacteria (DUF2256); Region: DUF2256; cl01792 114615002264 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 114615002265 NAD(P) binding site [chemical binding]; other site 114615002266 active site 114615002267 ABC-type Na+ transport system, ATPase component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatA; COG4555 114615002268 This family of ATP-binding proteins belongs to a multisubunit transporter involved in drug resistance (BcrA and DrrA), nodulation, lipid transport, and lantibiotic immunity. In bacteria and archaea, these transporters usually include an ATP-binding...; Region: ABC_DR_subfamily_A; cd03230 114615002269 Walker A/P-loop; other site 114615002270 ATP binding site [chemical binding]; other site 114615002271 Q-loop/lid; other site 114615002272 ABC transporter signature motif; other site 114615002273 Walker B; other site 114615002274 D-loop; other site 114615002275 H-loop/switch region; other site 114615002276 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 114615002277 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 114615002278 Cupin domain; Region: Cupin_2; cl09118 114615002279 Thermophilic metalloprotease (M29); Region: Peptidase_M29; pfam02073 114615002280 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 114615002281 active site 114615002282 metal binding site [ion binding]; metal-binding site 114615002283 Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300 114615002284 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 114615002285 NAD(P) binding site [chemical binding]; other site 114615002286 active site 114615002287 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124 114615002288 The ABC transporter subfamily specific for the transport of dipeptides, oligopeptides (OppD), and nickel (NikDE). The NikABCDE system of E. coli belongs to this family and is composed of the periplasmic binding protein NikA, two integral membrane...; Region: ABC_NikE_OppD_transporters; cd03257 114615002289 Walker A/P-loop; other site 114615002290 ATP binding site [chemical binding]; other site 114615002291 Q-loop/lid; other site 114615002292 ABC transporter signature motif; other site 114615002293 Walker B; other site 114615002294 D-loop; other site 114615002295 H-loop/switch region; other site 114615002296 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 114615002297 The ABC transporter subfamily specific for the transport of dipeptides, oligopeptides (OppD), and nickel (NikDE). The NikABCDE system of E. coli belongs to this family and is composed of the periplasmic binding protein NikA, two integral membrane...; Region: ABC_NikE_OppD_transporters; cd03257 114615002298 nickel import ATP-binding protein NikD; Region: nickel_nikD; TIGR02770 114615002299 Walker A/P-loop; other site 114615002300 ATP binding site [chemical binding]; other site 114615002301 Q-loop/lid; other site 114615002302 ABC transporter signature motif; other site 114615002303 Walker B; other site 114615002304 D-loop; other site 114615002305 H-loop/switch region; other site 114615002306 nickel ABC transporter, permease subunit NikC; Region: nickel_nikC; TIGR02790 114615002307 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261 114615002308 dimer interface [polypeptide binding]; other site 114615002309 conserved gate region; other site 114615002310 putative PBP binding loops; other site 114615002311 ABC-ATPase subunit interface; other site 114615002312 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 114615002313 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cl00427 114615002314 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cl01709 114615002315 Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496 114615002316 Dienelactone hydrolase and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG0412 114615002317 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109 114615002318 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 114615002319 heavy metal efflux pump (cobalt-zinc-cadmium); Region: 2A0601; TIGR00914 114615002320 Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154 114615002321 GGCT-like domains, also called AIG2-like family. Gamma-glutamyl cyclotransferase (GGCT) catalyzes the formation of pyroglutamic acid (5-oxoproline) from dipeptides containing gamma-glutamyl, and is a dimeric protein. In Homo sapiens, the protein is...; Region: GGCT_like; cl11426 114615002322 Transglutaminase-like superfamily; Region: Transglut_core; cl10469 114615002323 FecR protein; Region: FecR; pfam04773 114615002324 VCBS repeat; Region: VCBS_repeat; TIGR01965 114615002325 CHASE2 domain; Region: CHASE2; cl01732 114615002326 CHASE2 is an extracellular sensory domain, which is present in various classes of transmembrane receptors that are parts of signal transduction pathways in bacteria; Region: CHASE2; smart01080 114615002327 cyclase homology domain; Region: CHD; cd07302 114615002328 nucleotidyl binding site; other site 114615002329 metal binding site [ion binding]; metal-binding site 114615002330 dimer interface [polypeptide binding]; other site 114615002331 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_8; cd08495 114615002332 Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496 114615002333 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 114615002334 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_8; cd08495 114615002335 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 114615002336 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261 114615002337 dimer interface [polypeptide binding]; other site 114615002338 conserved gate region; other site 114615002339 putative PBP binding loops; other site 114615002340 ABC-ATPase subunit interface; other site 114615002341 nickel ABC transporter, permease subunit NikC; Region: nickel_nikC; TIGR02790 114615002342 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261 114615002343 dimer interface [polypeptide binding]; other site 114615002344 conserved gate region; other site 114615002345 putative PBP binding loops; other site 114615002346 ABC-ATPase subunit interface; other site 114615002347 dipeptide transporter ATP-binding subunit; Provisional; Region: dppF; PRK11308 114615002348 The ABC transporter subfamily specific for the transport of dipeptides, oligopeptides (OppD), and nickel (NikDE). The NikABCDE system of E. coli belongs to this family and is composed of the periplasmic binding protein NikA, two integral membrane...; Region: ABC_NikE_OppD_transporters; cd03257 114615002349 Walker A/P-loop; other site 114615002350 ATP binding site [chemical binding]; other site 114615002351 Q-loop/lid; other site 114615002352 ABC transporter signature motif; other site 114615002353 Walker B; other site 114615002354 D-loop; other site 114615002355 H-loop/switch region; other site 114615002356 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 114615002357 Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154 114615002358 GGCT-like domains, also called AIG2-like family. Gamma-glutamyl cyclotransferase (GGCT) catalyzes the formation of pyroglutamic acid (5-oxoproline) from dipeptides containing gamma-glutamyl, and is a dimeric protein. In Homo sapiens, the protein is...; Region: GGCT_like; cl11426 114615002359 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 114615002360 The ABC transporter subfamily specific for the transport of dipeptides, oligopeptides (OppD), and nickel (NikDE). The NikABCDE system of E. coli belongs to this family and is composed of the periplasmic binding protein NikA, two integral membrane...; Region: ABC_NikE_OppD_transporters; cd03257 114615002361 Walker A/P-loop; other site 114615002362 ATP binding site [chemical binding]; other site 114615002363 Q-loop/lid; other site 114615002364 ABC transporter signature motif; other site 114615002365 Walker B; other site 114615002366 D-loop; other site 114615002367 H-loop/switch region; other site 114615002368 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 114615002369 ABC-type protease/lipase transport system, ATPase and permease components [General function prediction only]; Region: ArpD; COG4618 114615002370 ABC transporter transmembrane region; Region: ABC_membrane; cl00549 114615002371 This family represents the ABC component of the protease secretion system PrtD, a 60-kDa integral membrane protein sharing 37% identity with HlyB, the ABC component of the alpha-hemolysin secretion pathway, in the C-terminal domain. They export...; Region: ABCC_Protease_Secretion; cd03246 114615002372 Walker A/P-loop; other site 114615002373 ATP binding site [chemical binding]; other site 114615002374 Q-loop/lid; other site 114615002375 ABC transporter signature motif; other site 114615002376 Walker B; other site 114615002377 D-loop; other site 114615002378 H-loop/switch region; other site 114615002379 type I secretion membrane fusion protein, HlyD family; Region: type_I_hlyD; TIGR01843 114615002380 Competence-damaged protein; Region: CinA; cl00666 114615002381 citrate-proton symporter; Provisional; Region: PRK15075 114615002382 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 114615002383 putative substrate translocation pore; other site 114615002384 DNA-binding transcriptional activator GcvA; Provisional; Region: PRK11139 114615002385 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 114615002386 HvR and beta-lactamase regulators, and that of other closely related homologs; contains the type 2 periplasmic binding fold; Region: PBP2_GcdR_TrpI_HvrB_AmpR_like; cd08432 114615002387 dimerization interface [polypeptide binding]; other site 114615002388 substrate binding pocket [chemical binding]; other site 114615002389 Domain of unknown function (DUF1127); Region: DUF1127; cl02276 114615002390 short chain dehydrogenase; Provisional; Region: PRK08219 114615002391 classical (c) SDR, subgroup 10; Region: SDR_c10; cd05373 114615002392 putative NAD(P) binding site [chemical binding]; other site 114615002393 active site 114615002394 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 114615002395 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 114615002396 C-terminal, alpha helical domain of the Glutathione S-transferase family; Region: GST_C_family; cd00299 114615002397 N-terminal domain interface [polypeptide binding]; other site 114615002398 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 114615002399 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 114615002400 active site 114615002401 Zn-dependent alcohol dehydrogenases, class III [Energy production and conversion]; Region: AdhC; COG1062 114615002402 Class III alcohol dehydrogenase; Region: Zn_ADH_class_III; cd08279 114615002403 NAD binding site [chemical binding]; other site 114615002404 catalytic Zn binding site [ion binding]; other site 114615002405 substrate binding site [chemical binding]; other site 114615002406 structural Zn binding site [ion binding]; other site 114615002407 amidase; Provisional; Region: PRK06170 114615002408 GGCT-like domains, also called AIG2-like family. Gamma-glutamyl cyclotransferase (GGCT) catalyzes the formation of pyroglutamic acid (5-oxoproline) from dipeptides containing gamma-glutamyl, and is a dimeric protein. In Homo sapiens, the protein is...; Region: GGCT_like; cl11426 114615002409 Cytochrome b (N-terminus)/b6/petB: Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria...; Region: Cytochrome_b_N; cl00859 114615002410 Uncharacterized family of ferritin-like proteins found in archaea and bacteria; Region: Ferritin_like_AB; cd01045 114615002411 diiron binding motif [ion binding]; other site 114615002412 Uncharacterized conserved protein [Function unknown]; Region: COG1633 114615002413 CCC1-related family of proteins; Region: CCC1_like; cl00278 114615002414 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 114615002415 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK08276 114615002416 Acyl-protein synthetase, LuxE; Region: LuxE; cl10450 114615002417 acetyl-CoA acetyltransferase; Provisional; Region: PRK06504 114615002418 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 114615002419 dimer interface [polypeptide binding]; other site 114615002420 active site 114615002421 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 114615002422 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 114615002423 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 114615002424 NAD(P) binding site [chemical binding]; other site 114615002425 active site 114615002426 enoyl-CoA hydratase; Provisional; Region: PRK06688 114615002427 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase...; Region: crotonase-like; cd06558 114615002428 substrate binding site [chemical binding]; other site 114615002429 oxyanion hole (OAH) forming residues; other site 114615002430 trimer interface [polypeptide binding]; other site 114615002431 acyl-CoA synthetase; Provisional; Region: PRK12582 114615002432 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 114615002433 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 114615002434 active site 114615002435 Putative acyl-CoA dehydrogenases similar to fadE6, fadE17, and fadE26; Region: ACAD_fadE6_17_26; cd01152 114615002436 FAD binding site [chemical binding]; other site 114615002437 substrate binding site [chemical binding]; other site 114615002438 catalytic base [active] 114615002439 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 114615002440 Putative acyl-CoA dehydrogenases similar to fadE6, fadE17, and fadE26; Region: ACAD_fadE6_17_26; cd01152 114615002441 FAD binding site [chemical binding]; other site 114615002442 substrate binding site [chemical binding]; other site 114615002443 catalytic base [active] 114615002444 Nitroreductase family. Members of this family utilize FMN as a cofactor and catalyze reduction of a variety of nitroaromatic compounds, including nitrofurans, nitrobenzens, nitrophenol, nitrobenzoate and quinones by using either NADH or NADPH as a...; Region: Nitroreductase; cd02136 114615002445 putative FMN binding site [chemical binding]; other site 114615002446 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 114615002447 Autoinducer binding domain; Region: Autoind_bind; pfam03472 114615002448 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors...; Region: LuxR_C_like; cd06170 114615002449 DNA binding residues [nucleotide binding] 114615002450 Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024 114615002451 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase...; Region: crotonase-like; cd06558 114615002452 substrate binding site [chemical binding]; other site 114615002453 oxyanion hole (OAH) forming residues; other site 114615002454 trimer interface [polypeptide binding]; other site 114615002455 Ion transport protein; Region: Ion_trans; pfam00520 114615002456 Ion channel; Region: Ion_trans_2; cl11596 114615002457 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 114615002458 ligand binding site [chemical binding]; other site 114615002459 flexible hinge region; other site 114615002460 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 114615002461 ligand binding site [chemical binding]; other site 114615002462 flexible hinge region; other site 114615002463 putative indolepyruvate oxidoreductase subunit B; Reviewed; Region: PRK08312 114615002464 Protein of unknown function (DUF3307); Region: DUF3307; pfam11750 114615002465 Flagellin N-methylase; Region: FliB; cl00497 114615002466 Predicted transcriptional regulator [Transcription]; Region: COG2378 114615002467 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 114615002468 Metaxin-like proteins; a heterogenous group of proteins, predominantly uncharacterized, with similarity to metaxins and GSTs. Metaxin 1 is a component of a preprotein import complex of the mitochondrial outer membrane. It extends to the cytosol and is...; Region: GST_N_Metaxin_like; cd03080 114615002469 putative C-terminal domain interface [polypeptide binding]; other site 114615002470 putative GSH binding site [chemical binding]; other site 114615002471 putative dimer interface [polypeptide binding]; other site 114615002472 C-terminal, alpha helical domain of Metaxin and related proteins; Region: GST_C_Metaxin; cd03193 114615002473 putative N-terminal domain interface [polypeptide binding]; other site 114615002474 Pyridoxine 5'-phosphate (PNP) oxidase-like proteins; Region: PNPOx_like; cl00381 114615002475 transcriptional regulator; Provisional; Region: PRK10632 114615002476 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 114615002477 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_2; cd08471 114615002478 putative effector binding pocket; other site 114615002479 putative dimerization interface [polypeptide binding]; other site 114615002480 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 114615002481 CoenzymeA binding site [chemical binding]; other site 114615002482 subunit interaction site [polypeptide binding]; other site 114615002483 PHB binding site; other site 114615002484 Bacterial extracellular solute-binding protein, family 7; Region: SBP_bac_7; cl00710 114615002485 Tripartite ATP-independent periplasmic transporters, DctQ component; Region: DctQ; cl01181 114615002486 DctM-like transporters; Region: DctM; pfam06808 114615002487 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl09110 114615002488 Protein of unknown function (DUF3237); Region: DUF3237; cl07905 114615002489 enoyl-CoA hydratase; Provisional; Region: PRK08150 114615002490 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase...; Region: crotonase-like; cd06558 114615002491 substrate binding site [chemical binding]; other site 114615002492 oxyanion hole (OAH) forming residues; other site 114615002493 trimer interface [polypeptide binding]; other site 114615002494 feruloyl-CoA synthase; Reviewed; Region: PRK08180 114615002495 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 114615002496 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 114615002497 NAD(P) binding site [chemical binding]; other site 114615002498 active site 114615002499 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active...; Region: 4HBT; cd00586 114615002500 active site 114615002501 Type I periplasmic binding component of ABC (ATPase Binding Cassette)-type transport systems that are predicted to be involved in uptake of amino acids; Region: PBP1_ABC-type_HAAT_like; cd06333 114615002502 putative ligand binding site [chemical binding]; other site 114615002503 Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501 114615002504 NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065 114615002505 shikimate binding site; other site 114615002506 NAD(P) binding site [chemical binding]; other site 114615002507 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410 114615002508 LivF (TM1139) is part of the LIV-I bacterial ABC-type two-component transport system that imports neutral, branched-chain amino acids. The E. coli branched-chain amino acid transporter comprises a heterodimer of ABC transporters (LivF and LivG), a...; Region: ABC_TM1139_LivF_branched; cd03224 114615002509 Walker A/P-loop; other site 114615002510 ATP binding site [chemical binding]; other site 114615002511 Q-loop/lid; other site 114615002512 ABC transporter signature motif; other site 114615002513 Walker B; other site 114615002514 D-loop; other site 114615002515 H-loop/switch region; other site 114615002516 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 114615002517 TM-ABC transporter signature motif; other site 114615002518 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411 114615002519 The Mj1267/LivG ABC transporter subfamily is involved in the transport of the hydrophobic amino acids leucine, isoleucine and valine. MJ1267 is a branched-chain amino acid transporter with 29% similarity to both the LivF and LivG components of the E...; Region: ABC_Mj1267_LivG_branched; cd03219 114615002520 Walker A/P-loop; other site 114615002521 ATP binding site [chemical binding]; other site 114615002522 Q-loop/lid; other site 114615002523 ABC transporter signature motif; other site 114615002524 Walker B; other site 114615002525 D-loop; other site 114615002526 H-loop/switch region; other site 114615002527 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 114615002528 TM-ABC transporter signature motif; other site 114615002529 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 114615002530 MOFRL family; Region: MOFRL; cl01013 114615002531 Type I periplasmic ligand-binding domain of uncharacterized ABC (ATPase Binding Cassette)-type active transport systems that are predicted to be involved in uptake of amino acids, peptides, or inorganic ions; Region: PBP1_ABC_ligand_binding_like_8; cd06343 114615002532 putative ligand binding site [chemical binding]; other site 114615002533 Type I periplasmic ligand-binding domain of uncharacterized ABC (ATPase Binding Cassette)-type active transport systems that are predicted to be involved in uptake of amino acids, peptides, or inorganic ions; Region: PBP1_ABC_ligand_binding_like_8; cd06343 114615002534 putative ligand binding site [chemical binding]; other site 114615002535 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 114615002536 TM-ABC transporter signature motif; other site 114615002537 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 114615002538 TM-ABC transporter signature motif; other site 114615002539 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410 114615002540 LivF (TM1139) is part of the LIV-I bacterial ABC-type two-component transport system that imports neutral, branched-chain amino acids. The E. coli branched-chain amino acid transporter comprises a heterodimer of ABC transporters (LivF and LivG), a...; Region: ABC_TM1139_LivF_branched; cd03224 114615002541 Walker A/P-loop; other site 114615002542 ATP binding site [chemical binding]; other site 114615002543 Q-loop/lid; other site 114615002544 ABC transporter signature motif; other site 114615002545 Walker B; other site 114615002546 D-loop; other site 114615002547 H-loop/switch region; other site 114615002548 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411 114615002549 The Mj1267/LivG ABC transporter subfamily is involved in the transport of the hydrophobic amino acids leucine, isoleucine and valine. MJ1267 is a branched-chain amino acid transporter with 29% similarity to both the LivF and LivG components of the E...; Region: ABC_Mj1267_LivG_branched; cd03219 114615002550 Walker A/P-loop; other site 114615002551 ATP binding site [chemical binding]; other site 114615002552 Q-loop/lid; other site 114615002553 ABC transporter signature motif; other site 114615002554 Walker B; other site 114615002555 D-loop; other site 114615002556 H-loop/switch region; other site 114615002557 Transcriptional regulator [Transcription]; Region: IclR; COG1414 114615002558 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 114615002559 Bacterial transcriptional regulator; Region: IclR; pfam01614 114615002560 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase...; Region: crotonase-like; cd06558 114615002561 multifunctional fatty acid oxidation complex subunit alpha; Reviewed; Region: fadJ; PRK11154 114615002562 substrate binding site [chemical binding]; other site 114615002563 oxyanion hole (OAH) forming residues; other site 114615002564 trimer interface [polypeptide binding]; other site 114615002565 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 114615002566 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 114615002567 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 114615002568 dicarboxylate--CoA ligase PimA; Region: pimA; TIGR03205 114615002569 Acyl-protein synthetase, LuxE; Region: LuxE; cl10450 114615002570 acetyl-CoA acetyltransferase; Provisional; Region: PRK07108 114615002571 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 114615002572 dimer interface [polypeptide binding]; other site 114615002573 active site 114615002574 pimeloyl-CoA dehydrogenase, large subunit; Region: pimC_large; TIGR03204 114615002575 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 114615002576 active site 114615002577 pimeloyl-CoA dehydrogenase, small subunit; Region: pimD_small; TIGR03203 114615002578 Acyl-CoA dehydrogenase; Region: ACAD; cd00567 114615002579 active site 114615002580 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 114615002581 classical (c) SDRs; Region: SDR_c; cd05233 114615002582 NAD(P) binding site [chemical binding]; other site 114615002583 active site 114615002584 glycerol kinase; Provisional; Region: glpK; PRK00047 114615002585 Escherichia coli glycerol kinase-like proteins; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_EcGK_like; cd07786 114615002586 N- and C-terminal domain interface [polypeptide binding]; other site 114615002587 active site 114615002588 MgATP binding site [chemical binding]; other site 114615002589 catalytic site [active] 114615002590 metal binding site [ion binding]; metal-binding site 114615002591 glycerol binding site [chemical binding]; other site 114615002592 homotetramer interface [polypeptide binding]; other site 114615002593 homodimer interface [polypeptide binding]; other site 114615002594 FBP binding site [chemical binding]; other site 114615002595 protein IIAGlc interface [polypeptide binding]; other site 114615002596 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 114615002597 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 114615002598 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 114615002599 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 114615002600 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 114615002601 C-terminal, alpha helical domain of the Glutathione S-transferase family; Region: GST_C_family; cl02776 114615002602 N-terminal domain interface [polypeptide binding]; other site 114615002603 dimer interface [polypeptide binding]; other site 114615002604 substrate binding pocket (H-site) [chemical binding]; other site 114615002605 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 114615002606 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 114615002607 This family is comprised of MJ0796 ATP-binding cassette, macrolide-specific ABC-type efflux carrier (MacAB), and proteins involved in cell division (FtsE), and release of liporoteins from the cytoplasmic membrane (LolCDE). They are clustered together...; Region: ABC_MJ0796_Lo1CDE_FtsE; cd03255 114615002608 Walker A/P-loop; other site 114615002609 ATP binding site [chemical binding]; other site 114615002610 Q-loop/lid; other site 114615002611 ABC transporter signature motif; other site 114615002612 Walker B; other site 114615002613 D-loop; other site 114615002614 H-loop/switch region; other site 114615002615 DevC protein; Region: devC; TIGR01185 114615002616 B12-dependent methionine synthase; Provisional; Region: metH; PRK09490 114615002617 Homocysteine/selenocysteine methylase (S-methylmethionine-dependent) [Amino acid transport and metabolism]; Region: MHT1; cl14105 114615002618 MeTr subgroup of pterin binding enzymes. This family includes cobalamin-dependent methyltransferases such as methyltetrahydrofolate, corrinoid iron-sulfur protein methyltransferase (MeTr) and methionine synthase (MetH). Cobalamin-dependent...; Region: MeTr; cd00740 114615002619 substrate binding pocket [chemical binding]; other site 114615002620 B12 binding domain of methionine synthase. This domain binds methylcobalamin, which it uses as an intermediate methyl carrier from methyltetrahydrofolate (CH3H4folate) to homocysteine (Hcy); Region: methionine_synthase_B12_BD; cd02069 114615002621 B12 binding site [chemical binding]; other site 114615002622 cobalt ligand [ion binding]; other site 114615002623 Vitamin B12 dependent methionine synthase, activation domain; Region: Met_synt_B12; pfam02965 114615002624 Methylenetetrahydrofolate reductase; Region: MTHFR; pfam02219 114615002625 Methylenetetrahydrofolate reductase (MTHFR). 5,10-Methylenetetrahydrofolate is reduced to 5-methyltetrahydrofolate by methylenetetrahydrofolate reductase, a cytoplasmic, NAD(P)-dependent enzyme. 5-methyltetrahydrofolate is utilized by methionine...; Region: MTHFR; cd00537 114615002626 FAD binding site [chemical binding]; other site 114615002627 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases [Energy production and conversion]; Region: COG2141 114615002628 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 114615002629 biliverdin IX beta reductase (BVR-B, aka flavin reductase)-like proteins; atypical (a) SDRs; Region: BVR-B_like_SDR_a; cd05244 114615002630 NAD binding site [chemical binding]; other site 114615002631 substrate binding site [chemical binding]; other site 114615002632 putative active site [active] 114615002633 LysR family transcriptional regulator; Provisional; Region: PRK14997 114615002634 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 114615002635 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 114615002636 dimerization interface [polypeptide binding]; other site 114615002637 prephenate dehydratase; Provisional; Region: PRK11899 114615002638 Prephenate dehydratase; Region: PDT; pfam00800 114615002639 C-terminal ACT domain of the bifunctional chorismate mutase-prephenate dehydratase (CM-PDT) enzyme and the prephenate dehydratase (PDT) enzyme; Region: ACT_CM-PDT; cd04905 114615002640 putative L-Phe binding site [chemical binding]; other site 114615002641 CMP-KDO synthetase catalyzes the activation of KDO which is an essential component of the lipopolysaccharide; Region: CMP-KDO-Synthetase; cd02517 114615002642 Ligand binding site [chemical binding]; other site 114615002643 oligomer interface [polypeptide binding]; other site 114615002644 Cytochrome c; Region: Cytochrom_C; cl11414 114615002645 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 114615002646 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_14; cd08497 114615002647 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 114615002648 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_14; cd08497 114615002649 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 114615002650 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261 114615002651 dimer interface [polypeptide binding]; other site 114615002652 conserved gate region; other site 114615002653 putative PBP binding loops; other site 114615002654 ABC-ATPase subunit interface; other site 114615002655 ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG4239 114615002656 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261 114615002657 dimer interface [polypeptide binding]; other site 114615002658 conserved gate region; other site 114615002659 ABC-ATPase subunit interface; other site 114615002660 ABC-type uncharacterized transport system, duplicated ATPase component [General function prediction only]; Region: COG4172 114615002661 The ABC transporter subfamily specific for the transport of dipeptides, oligopeptides (OppD), and nickel (NikDE). The NikABCDE system of E. coli belongs to this family and is composed of the periplasmic binding protein NikA, two integral membrane...; Region: ABC_NikE_OppD_transporters; cd03257 114615002662 Walker A/P-loop; other site 114615002663 ATP binding site [chemical binding]; other site 114615002664 Q-loop/lid; other site 114615002665 ABC transporter signature motif; other site 114615002666 Walker B; other site 114615002667 D-loop; other site 114615002668 H-loop/switch region; other site 114615002669 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 114615002670 The ABC transporter subfamily specific for the transport of dipeptides, oligopeptides (OppD), and nickel (NikDE). The NikABCDE system of E. coli belongs to this family and is composed of the periplasmic binding protein NikA, two integral membrane...; Region: ABC_NikE_OppD_transporters; cd03257 114615002671 Walker A/P-loop; other site 114615002672 ATP binding site [chemical binding]; other site 114615002673 Q-loop/lid; other site 114615002674 ABC transporter signature motif; other site 114615002675 Walker B; other site 114615002676 D-loop; other site 114615002677 H-loop/switch region; other site 114615002678 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 114615002679 NlpC/P60 family; Region: NLPC_P60; cl11438 114615002680 Cytosol aminopeptidase family, N-terminal and catalytic domains. Family M17 contains zinc- and manganese-dependent exopeptidases ( EC 3.4.11.1), including leucine aminopeptidase. They catalyze removal of amino acids from the N-terminus of a protein...; Region: Peptidase_M17; cd00433 114615002681 Leucyl aminopeptidase [Amino acid transport and metabolism]; Region: PepB; COG0260 114615002682 interface (dimer of trimers) [polypeptide binding]; other site 114615002683 Substrate-binding/catalytic site; other site 114615002684 Zn-binding sites [ion binding]; other site 114615002685 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi...; Region: TPR; cd00189 114615002686 TPR motif; other site 114615002687 binding surface 114615002688 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi...; Region: TPR; cd00189 114615002689 TPR motif; other site 114615002690 binding surface 114615002691 allantoate amidohydrolase; Reviewed; Region: PRK12892 114615002692 M20 Peptidase beta-alanine synthase, an amidohydrolase; Region: M20_bAS; cd03884 114615002693 active site 114615002694 metal binding site [ion binding]; metal-binding site 114615002695 dimer interface [polypeptide binding]; other site 114615002696 Bacterial type II secretion system protein F domain; Region: GSPII_F; cl00906 114615002697 Bacterial type II secretion system protein F domain; Region: GSPII_F; cl00906 114615002698 Flp pilus assembly protein, ATPase CpaF [Intracellular trafficking and secretion]; Region: CpaF; COG4962 114615002699 Type IV secretory pathway component VirB11, and related ATPases. The homohexamer, VirB11 is one of eleven Vir proteins, which are required for T-pilus biogenesis and virulence in the transfer of T-DNA from the Ti (tumor-inducing) plasmid of bacterial...; Region: VirB11-like_ATPase; cd01130 114615002700 ATP binding site [chemical binding]; other site 114615002701 Walker A motif; other site 114615002702 hexamer interface [polypeptide binding]; other site 114615002703 Walker B motif; other site 114615002704 Flp pilus assembly protein, ATPase CpaE [Intracellular trafficking and secretion]; Region: CpaE; COG4963 114615002705 Ras-like GTPase superfamily. The Ras-like superfamily of small GTPases consists of several families with an extremely high degree of structural and functional similarity. The Ras superfamily is divided into at least four families in eukaryotes: the Ras...; Region: Ras_like_GTPase; cl10444 114615002706 This protein family consists of proteins similar to the cpaE protein of the Caulobacter pilus assembly and the orf4 protein of Actinobacillus pilus formation gene cluster. The function of these proteins are unkown. The Caulobacter pilus assembly...; Region: CpaE_like; cd03111 114615002707 Type IV pili component [Cell motility and secretion]; Region: COG5461; cl02279 114615002708 Pilus biogenesis CpaD protein (pilus_cpaD); Region: Pilus_CpaD; pfam09476 114615002709 Flp pilus assembly protein, secretin CpaC [Intracellular trafficking and secretion]; Region: CpaC; COG4964 114615002710 Bacterial type II and III secretion system protein; Region: Secretin; cl02829 114615002711 SAF domain; Region: SAF; cl00555 114615002712 Type IV leader peptidase family; Region: Peptidase_A24; cl02077 114615002713 Fatty acid hydroxylase superfamily; Region: FA_hydroxylase; cl01132 114615002714 Flp pilus assembly protein, secretin CpaC [Intracellular trafficking and secretion]; Region: CpaC; COG4964 114615002715 TadE-like protein; Region: TadE; pfam07811 114615002716 Flp pilus assembly protein TadG [Intracellular trafficking and secretion]; Region: TadG; COG4961 114615002717 TadE-like protein; Region: TadE; pfam07811 114615002718 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box protein...; Region: CSP_CDS; cd04458 114615002719 DNA-binding site [nucleotide binding]; DNA binding site 114615002720 RNA-binding motif; other site 114615002721 S1_IF1: Translation Initiation Factor IF1, S1-like RNA-binding domain. IF1 contains an S1-like RNA-binding domain, which is found in a wide variety of RNA-associated proteins. Translation initiation includes a number of interrelated steps preceding the...; Region: S1_IF1; cd04451 114615002722 rRNA binding site [nucleotide binding]; other site 114615002723 predicted 30S ribosome binding site; other site 114615002724 ATP-dependent RNA helicase RhlE; Provisional; Region: PRK10590 114615002725 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (...; Region: DEADc; cd00268 114615002726 ATP binding site [chemical binding]; other site 114615002727 Mg++ binding site [ion binding]; other site 114615002728 motif III; other site 114615002729 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 114615002730 nucleotide binding region [chemical binding]; other site 114615002731 ATP-binding site [chemical binding]; other site 114615002732 ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683 114615002733 Periplasmic component (FmdD) of an active transport system for short-chain amides and urea (FmdDEF); Region: PBP1_FmdD_like; cd06355 114615002734 putative ligand binding site [chemical binding]; other site 114615002735 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 114615002736 TM-ABC transporter signature motif; other site 114615002737 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 114615002738 TM-ABC transporter signature motif; other site 114615002739 urea ABC transporter, ATP-binding protein UrtD; Region: urea_trans_UrtD; TIGR03411 114615002740 The Mj1267/LivG ABC transporter subfamily is involved in the transport of the hydrophobic amino acids leucine, isoleucine and valine. MJ1267 is a branched-chain amino acid transporter with 29% similarity to both the LivF and LivG components of the E...; Region: ABC_Mj1267_LivG_branched; cd03219 114615002741 Walker A/P-loop; other site 114615002742 ATP binding site [chemical binding]; other site 114615002743 Q-loop/lid; other site 114615002744 ABC transporter signature motif; other site 114615002745 Walker B; other site 114615002746 D-loop; other site 114615002747 H-loop/switch region; other site 114615002748 urea ABC transporter, ATP-binding protein UrtE; Region: urea_trans_UrtE; TIGR03410 114615002749 LivF (TM1139) is part of the LIV-I bacterial ABC-type two-component transport system that imports neutral, branched-chain amino acids. The E. coli branched-chain amino acid transporter comprises a heterodimer of ABC transporters (LivF and LivG), a...; Region: ABC_TM1139_LivF_branched; cd03224 114615002750 Walker A/P-loop; other site 114615002751 ATP binding site [chemical binding]; other site 114615002752 Q-loop/lid; other site 114615002753 ABC transporter signature motif; other site 114615002754 Walker B; other site 114615002755 D-loop; other site 114615002756 H-loop/switch region; other site 114615002757 UreD urease accessory protein; Region: UreD; cl00530 114615002758 Urease gamma-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, archaea, fungi and plants. Their primary role is to allow the use...; Region: Urease_gamma; cd00390 114615002759 alpha-gamma subunit interface [polypeptide binding]; other site 114615002760 beta-gamma subunit interface [polypeptide binding]; other site 114615002761 Urease beta-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, archaea, fungi and plants. Their primary role is to allow the use...; Region: Urease_beta; cd00407 114615002762 gamma-beta subunit interface [polypeptide binding]; other site 114615002763 alpha-beta subunit interface [polypeptide binding]; other site 114615002764 (p)ppGpp synthetase, RelA/SpoT family; Region: spoT_relA; TIGR00691 114615002765 urease subunit alpha; Reviewed; Region: ureC; PRK13207 114615002766 Urease alpha-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, fungi and plants. Their primary role is to allow the use of...; Region: Urease_alpha; cd00375 114615002767 subunit interactions [polypeptide binding]; other site 114615002768 active site 114615002769 flap region; other site 114615002770 Antibiotic biosynthesis monooxygenase; Region: ABM; cl10022 114615002771 urease accessory protein UreE; Provisional; Region: ureE; PRK13261 114615002772 UreE urease accessory protein. UreE is a metallochaperone assisting the insertion of a Ni2+ ion in the active site of urease, an important step in the in vivo assembly of urease, an enzyme that hydrolyses urea into ammonia and carbamic acid. The C-...; Region: UreE; cd00571 114615002773 dimer interface [polypeptide binding]; other site 114615002774 catalytic residues [active] 114615002775 Urease accessory protein UreF [Posttranslational modification, protein turnover, chaperones]; Region: UreF; COG0830 114615002776 UreF; Region: UreF; pfam01730 114615002777 Ras-like GTPase superfamily. The Ras-like superfamily of small GTPases consists of several families with an extremely high degree of structural and functional similarity. The Ras superfamily is divided into at least four families in eukaryotes: the Ras...; Region: Ras_like_GTPase; cl10444 114615002778 CHASE domain; Region: CHASE; cl01369 114615002779 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920 114615002780 Histidine kinase; Region: HisKA_2; cl06527 114615002781 RNA polymerase sigma factor; Provisional; Region: PRK12540 114615002782 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 114615002783 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial...; Region: Sigma70_r4; cd06171 114615002784 DNA binding residues [nucleotide binding] 114615002785 two-component response regulator; Provisional; Region: PRK09191 114615002786 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156 114615002787 active site 114615002788 phosphorylation site [posttranslational modification] 114615002789 intermolecular recognition site; other site 114615002790 dimerization interface [polypeptide binding]; other site 114615002791 Gram-negative bacterial tonB protein; Region: TonB; cl10048 114615002792 Bacterial protein of unknown function (DUF883); Region: DUF883; cl01888 114615002793 Domain of unknown function DUF20; Region: UPF0118; cl00465 114615002794 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 114615002795 Protein of unknown function (DUF2865); Region: DUF2865; pfam11064 114615002796 TMAO reductase sytem sensor TorS; Region: TMAO_torS; TIGR02956 114615002797 Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices connected by an extended linker. The...; Region: HAMP; cl01054 114615002798 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 114615002799 Taxis toward Aspartate and Related amino acids and Homologs (TarH). The Tar chemoreceptor of Escherichia coli mediates attractant responses to aspartate, maltose, and phenol, repellent responses to Ni2+ and Co2+, and thermoresponses. These...; Region: TarH; cl00144 114615002800 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl09155 114615002801 active site 114615002802 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase...; Region: crotonase-like; cl14780 114615002803 Cytochrome c peroxidase [Inorganic ion transport and metabolism]; Region: MauG; COG1858 114615002804 CysN_ATPS subfamily. CysN, together with protein CysD, form the ATP sulfurylase (ATPS) complex in some bacteria and lower eukaryotes. ATPS catalyzes the production of ATP sulfurylase (APS) and pyrophosphate (PPi) from ATP and sulfate. CysD, which...; Region: CysN_ATPS; cd04166 114615002805 bifunctional sulfate adenylyltransferase subunit 1/adenylylsulfate kinase protein; Provisional; Region: PRK05506 114615002806 G1 box; other site 114615002807 putative GEF interaction site [polypeptide binding]; other site 114615002808 GTP/Mg2+ binding site [chemical binding]; other site 114615002809 Switch I region; other site 114615002810 G2 box; other site 114615002811 CysD dimerization site [polypeptide binding]; other site 114615002812 G3 box; other site 114615002813 Switch II region; other site 114615002814 G4 box; other site 114615002815 G5 box; other site 114615002816 CysN_NodQ_II: This subfamily represents the domain II of the large subunit of ATP sulfurylase (ATPS): CysN or the N-terminal portion of NodQ, found mainly in proteobacteria and homologous to the domain II of EF-Tu. Escherichia coli ATPS consists of...; Region: CysN_NodQ_II; cd03695 114615002817 TCysN_NoDQ_II: This subfamily represents the domain II of the large subunit of ATP sulfurylase (ATPS): CysN or the N-terminal portion of NodQ, found mainly in proteobacteria and homologous to the domain II of EF-Tu. Escherichia coli ATPS consists of...; Region: CysN_NoDQ_III; cd04095 114615002818 Adenosine 5'-phosphosulfate kinase (APSK) catalyzes the phosphorylation of adenosine 5'-phosphosulfate to form 3'-phosphoadenosine 5'-phosphosulfate (PAPS). The end-product PAPS is a biologically 'activated' sulfate form important for the assimilation...; Region: APSK; cd02027 114615002819 ligand-binding site [chemical binding]; other site 114615002820 sulfate adenylyltransferase, small subunit; Region: CysD; TIGR02039 114615002821 This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713 114615002822 Active Sites [active] 114615002823 siroheme synthase; Provisional; Region: cysG; PRK10637 114615002824 precorrin-2 dehydrogenase; Validated; Region: PRK06719 114615002825 Sirohaem synthase dimerisation region; Region: CysG_dimeriser; pfam10414 114615002826 Tetrapyrrole (Corrin/Porphyrin) Methylases; Region: TP_methylase; cl00304 114615002827 Protein of unknown function (DUF2849); Region: DUF2849; pfam11011 114615002828 Sulfite reductase, beta subunit (hemoprotein) [Inorganic ion transport and metabolism]; Region: CysI; COG0155 114615002829 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 114615002830 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 114615002831 Bacterial protein of unknown function (DUF934); Region: DUF934; cl01526 114615002832 This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713 114615002833 Active Sites [active] 114615002834 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 114615002835 ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555 114615002836 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261 114615002837 dimer interface [polypeptide binding]; other site 114615002838 conserved gate region; other site 114615002839 putative PBP binding loops; other site 114615002840 ABC-ATPase subunit interface; other site 114615002841 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261 114615002842 dimer interface [polypeptide binding]; other site 114615002843 conserved gate region; other site 114615002844 putative PBP binding loops; other site 114615002845 ABC-ATPase subunit interface; other site 114615002846 ABC-type sulfate/molybdate transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: CysA; COG1118 114615002847 Part of the ABC transporter complex cysAWTP involved in sulfate import. Responsible for energy coupling to the transport system. The complex is composed of two ATP-binding proteins (cysA), two transmembrane proteins (cysT and cysW), and a solute-...; Region: ABC_CysA_sulfate_importer; cd03296 114615002848 Walker A/P-loop; other site 114615002849 ATP binding site [chemical binding]; other site 114615002850 Q-loop/lid; other site 114615002851 ABC transporter signature motif; other site 114615002852 Walker B; other site 114615002853 D-loop; other site 114615002854 H-loop/switch region; other site 114615002855 TOBE-like domain; Region: TOBE_3; pfam12857 114615002856 SCP_bacterial: SCP-like extracellular protein domain, as found in bacteria and archaea. The wider family of SCP containing proteins includes plant pathogenesis-related protein 1 (PR-1), CRISPs, mammalian cysteine-rich secretory proteins, and allergen 5...; Region: SCP_bacterial; cd05379 114615002857 Predicted esterase of the alpha-beta hydrolase superfamily [General function prediction only]; Region: RssA; COG1752 114615002858 Hypothetical patatin similar to Z1214 protein of Escherichia coli; Region: Pat_hypo_Ecoli_Z1214_like; cd07209 114615002859 active site 114615002860 nucleophile elbow; other site 114615002861 Patatin phospholipase; Region: DUF3734; pfam12536 114615002862 d-3-hydroxybutyrate dehydrogenase (HBDH), classical (c) SDRs; Region: HBDH_SDR_c; cd08940 114615002863 3-hydroxybutyrate dehydrogenase; Region: PHB_DH; TIGR01963 114615002864 NAD binding site [chemical binding]; other site 114615002865 homotetramer interface [polypeptide binding]; other site 114615002866 homodimer interface [polypeptide binding]; other site 114615002867 substrate binding site [chemical binding]; other site 114615002868 active site 114615002869 PQ loop repeat; Region: PQ-loop; cl12056 114615002870 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 114615002871 Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244 114615002872 MatE; Region: MatE; cl10513 114615002873 Uncharacterized protein predicted to be involved in C-type cytochrome biogenesis [Posttranslational modification, protein turnover, chaperones / Energy production and conversion]; Region: COG4233 114615002874 Uncharacterized ACR, COG1678; Region: DUF179; cl00731 114615002875 Probable taurine catabolism dioxygenase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: TauD; COG2175 114615002876 Clavaminic acid synthetase (CAS) -like; CAS is a trifunctional Fe(II)/ 2-oxoglutarate (2OG) oxygenase carrying out three reactions in the biosynthesis of clavulanic acid, an inhibitor of class A serine beta-lactamases. In general, Fe(II)-2OG...; Region: CAS_like; cl00184 114615002877 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 114615002878 classical (c) SDRs; Region: SDR_c; cd05233 114615002879 NAD(P) binding site [chemical binding]; other site 114615002880 active site 114615002881 Glucose/sorbosone dehydrogenases [Carbohydrate transport and metabolism]; Region: COG2133 114615002882 Glucose / Sorbosone dehydrogenase; Region: GSDH; pfam07995 114615002883 gluconate 5-dehydrogenase; Provisional; Region: PRK08213 114615002884 classical (c) SDRs; Region: SDR_c; cd05233 114615002885 NAD(P) binding site [chemical binding]; other site 114615002886 active site 114615002887 CsbD-like; Region: CsbD; cl01272 114615002888 SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cl01053 114615002889 active site 114615002890 oxyanion hole [active] 114615002891 SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cl01053 114615002892 catalytic triad [active] 114615002893 lysozyme_like domain. This contains several members including Soluble Lytic Transglycosylases (SLT), Goose Egg-White Lysozymes (GEWL), Hen Egg-White Lysozymes (HEWL), chitinases, bacteriophage lambda lysozymes, endolysins, autolysins, and chitosanases...; Region: lysozyme_like; cl00222 114615002894 lytic murein transglycosylase; Region: MltB_2; TIGR02283 114615002895 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 114615002896 Prokaryotic UGPase catalyses the synthesis of UDP-glucose; Region: UGPase_prokaryotic; cd02541 114615002897 active site 114615002898 tetramer interface [polypeptide binding]; other site 114615002899 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 114615002900 metal binding site [ion binding]; metal-binding site 114615002901 active site 114615002902 I-site; other site 114615002903 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 114615002904 The substrate-binding component of ABC-type thermophilic oligopeptide-binding protein Hb8-like import systems, contains the type 2 periplasmic binding fold; Region: PBP2_thermophilic_Hb8_like; cd08513 114615002905 peptide binding site [polypeptide binding]; other site 114615002906 dimer interface [polypeptide binding]; other site 114615002907 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 114615002908 The substrate-binding component of ABC-type thermophilic oligopeptide-binding protein Hb8-like import systems, contains the type 2 periplasmic binding fold; Region: PBP2_thermophilic_Hb8_like; cd08513 114615002909 peptide binding site [polypeptide binding]; other site 114615002910 dimer interface [polypeptide binding]; other site 114615002911 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 114615002912 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261 114615002913 dimer interface [polypeptide binding]; other site 114615002914 conserved gate region; other site 114615002915 putative PBP binding loops; other site 114615002916 ABC-ATPase subunit interface; other site 114615002917 nickel ABC transporter, permease subunit NikC; Region: nickel_nikC; TIGR02790 114615002918 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261 114615002919 dimer interface [polypeptide binding]; other site 114615002920 conserved gate region; other site 114615002921 putative PBP binding loops; other site 114615002922 ABC-ATPase subunit interface; other site 114615002923 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 114615002924 The ABC transporter subfamily specific for the transport of dipeptides, oligopeptides (OppD), and nickel (NikDE). The NikABCDE system of E. coli belongs to this family and is composed of the periplasmic binding protein NikA, two integral membrane...; Region: ABC_NikE_OppD_transporters; cd03257 114615002925 Walker A/P-loop; other site 114615002926 ATP binding site [chemical binding]; other site 114615002927 Q-loop/lid; other site 114615002928 ABC transporter signature motif; other site 114615002929 Walker B; other site 114615002930 D-loop; other site 114615002931 H-loop/switch region; other site 114615002932 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 114615002933 dipeptide transporter ATP-binding subunit; Provisional; Region: dppF; PRK11308 114615002934 The ABC transporter subfamily specific for the transport of dipeptides, oligopeptides (OppD), and nickel (NikDE). The NikABCDE system of E. coli belongs to this family and is composed of the periplasmic binding protein NikA, two integral membrane...; Region: ABC_NikE_OppD_transporters; cd03257 114615002935 Walker A/P-loop; other site 114615002936 ATP binding site [chemical binding]; other site 114615002937 Q-loop/lid; other site 114615002938 ABC transporter signature motif; other site 114615002939 Walker B; other site 114615002940 D-loop; other site 114615002941 H-loop/switch region; other site 114615002942 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 114615002943 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4564 114615002944 Cache domain; Region: Cache_2; cl07034 114615002945 Taxis toward Aspartate and Related amino acids and Homologs (TarH). The Tar chemoreceptor of Escherichia coli mediates attractant responses to aspartate, maltose, and phenol, repellent responses to Ni2+ and Co2+, and thermoresponses. These...; Region: TarH; cl00144 114615002946 PilZ domain; Region: PilZ; cl01260 114615002947 feruloyl-CoA synthase; Reviewed; Region: PRK08180 114615002948 Acyl-protein synthetase, LuxE; Region: LuxE; cl10450 114615002949 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 114615002950 7TMR-DISM extracellular 2; Region: 7TMR-DISMED2; pfam07696 114615002951 7TM diverse intracellular signalling; Region: 7TMR-DISM_7TM; pfam07695 114615002952 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 114615002953 PAS fold; Region: PAS_3; pfam08447 114615002954 putative active site [active] 114615002955 heme pocket [chemical binding]; other site 114615002956 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 114615002957 metal binding site [ion binding]; metal-binding site 114615002958 active site 114615002959 I-site; other site 114615002960 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 114615002961 putative NAD(P)H quinone oxidoreductase, PIG3 family; Region: quinone_pig3; TIGR02824 114615002962 PIG3 p53-inducible quinone oxidoreductase; Region: p53_inducible_oxidoreductase; cd05276 114615002963 NAD(P) binding site [chemical binding]; other site 114615002964 Protein of unknown function (DUF1192); Region: DUF1192; cl11573 114615002965 Protein of unknown function (DUF1465); Region: DUF1465; cl11562 114615002966 Ribosomal protein L31; Region: Ribosomal_L31; cl00377 114615002967 ABC transporter, permease/ATP-binding protein; Region: MsbA_rel; TIGR02204 114615002968 ABC transporter transmembrane region; Region: ABC_membrane; cl00549 114615002969 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 114615002970 Walker A/P-loop; other site 114615002971 ATP binding site [chemical binding]; other site 114615002972 Q-loop/lid; other site 114615002973 ABC transporter signature motif; other site 114615002974 Walker B; other site 114615002975 D-loop; other site 114615002976 H-loop/switch region; other site 114615002977 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 114615002978 hypothetical protein; Validated; Region: PRK09039 114615002979 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 114615002980 ligand binding site [chemical binding]; other site 114615002981 Isoprenylcysteine carboxyl methyltransferase (ICMT) family; Region: ICMT; cl00763 114615002982 Cyclopropane fatty acid synthase and related methyltransferases [Cell envelope biogenesis, outer membrane]; Region: Cfa; COG2230 114615002983 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cd02440 114615002984 S-adenosylmethionine binding site [chemical binding]; other site 114615002985 periplasmic multidrug efflux lipoprotein precursor; Reviewed; Region: PRK09578 114615002986 The (Largely Gram-negative Bacterial) Hydrophobe/Amphiphile Efflux-1 (HAE1) Family; Region: 2A0602; TIGR00915 114615002987 IMPase, inositol monophosphatase and related domains. A family of Mg++ dependent phosphatases, inhibited by lithium, many of which may act on inositol monophosphate substrate. They dephosphorylate inositol phosphate to generate inositol, which may be...; Region: IMPase; cd01639 114615002988 active site 114615002989 dimerization interface [polypeptide binding]; other site 114615002990 FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790 114615002991 Sel1 repeat; Region: Sel1; cl02723 114615002992 Sel1 repeat; Region: Sel1; cl02723 114615002993 Sel1 repeat; Region: Sel1; cl02723 114615002994 Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5- (beta-...; Region: TMP_TenI; cd00564 114615002995 thiamine phosphate binding site [chemical binding]; other site 114615002996 active site 114615002997 pyrophosphate binding site [ion binding]; other site 114615002998 hypothetical protein; Provisional; Region: PRK08185 114615002999 Tagatose-1,6-bisphosphate (TBP) aldolase and related Type B Class II aldolases. TBP aldolase is a tetrameric class II aldolase that catalyzes the reversible condensation of dihydroxyacetone phosphate with glyceraldehyde 3-phsophate to produce tagatose...; Region: TBP_aldolase_IIB; cd00947 114615003000 intersubunit interface [polypeptide binding]; other site 114615003001 active site 114615003002 zinc binding site [ion binding]; other site 114615003003 Na+ binding site [ion binding]; other site 114615003004 Phosphoglycerate kinase (PGK) is a monomeric enzyme which catalyzes the transfer of the high-energy phosphate group of 1,3-bisphosphoglycerate to ADP, forming ATP and 3-phosphoglycerate. This reaction represents the first of the two substrate-level...; Region: Phosphoglycerate_kinase; cd00318 114615003005 substrate binding site [chemical binding]; other site 114615003006 hinge regions; other site 114615003007 ADP binding site [chemical binding]; other site 114615003008 catalytic site [active] 114615003009 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; cl15267 114615003010 glyceraldehyde-3-phosphate dehydrogenase, type I; Region: GAPDH-I; TIGR01534 114615003011 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800 114615003012 ATP-dependent DNA helicase RecQ; Region: recQ; TIGR01389 114615003013 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 114615003014 ATP binding site [chemical binding]; other site 114615003015 putative Mg++ binding site [ion binding]; other site 114615003016 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 114615003017 nucleotide binding region [chemical binding]; other site 114615003018 ATP-binding site [chemical binding]; other site 114615003019 RQC domain; Region: RQC; cl09632 114615003020 HRDC domain; Region: HRDC; cl02578 114615003021 transketolase; Reviewed; Region: PRK05899 114615003022 Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012 114615003023 TPP-binding site [chemical binding]; other site 114615003024 dimer interface [polypeptide binding]; other site 114615003025 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 114615003026 PYR/PP interface [polypeptide binding]; other site 114615003027 dimer interface [polypeptide binding]; other site 114615003028 TPP binding site [chemical binding]; other site 114615003029 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 114615003030 Cell division protein ZapA; Region: ZapA; cl01146 114615003031 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109 114615003032 Beta-lactamase; Region: Beta-lactamase; cl01009 114615003033 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 114615003034 GST_N family, Saccharomyces cerevisiae GTT1-like subfamily; composed of predominantly uncharacterized proteins with similarity to the S. cerevisiae GST protein, GTT1, and the Schizosaccharomyces pombe GST-III. GSTs are cytosolic dimeric proteins...; Region: GST_N_GTT1_like; cd03046 114615003035 putative C-terminal domain interface [polypeptide binding]; other site 114615003036 putative GSH binding site (G-site) [chemical binding]; other site 114615003037 putative dimer interface [polypeptide binding]; other site 114615003038 C-terminal, alpha helical domain of the Glutathione S-transferase family; Region: GST_C_family; cl02776 114615003039 N-terminal domain interface [polypeptide binding]; other site 114615003040 dimer interface [polypeptide binding]; other site 114615003041 substrate binding pocket (H-site) [chemical binding]; other site 114615003042 TRAP-type uncharacterized transport system, periplasmic component [General function prediction only]; Region: Imp; COG2358 114615003043 Tripartite tricarboxylate transporter family receptor; Region: TctC; cl15260 114615003044 DsrE/DsrF-like family; Region: DrsE; cl00672 114615003045 5-formyltetrahydrofolate cyclo-ligase family; Region: 5-FTHF_cyc-lig; cl00360 114615003046 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 114615003047 Deinococcus radiodurans DR1281 and related proteins, metallophosphatase domain; Region: MPP_DR1281; cd07382 114615003048 putative active site [active] 114615003049 metal binding site [ion binding]; metal-binding site 114615003050 homodimer binding site [polypeptide binding]; other site 114615003051 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 114615003052 Taxis toward Aspartate and Related amino acids and Homologs (TarH). The Tar chemoreceptor of Escherichia coli mediates attractant responses to aspartate, maltose, and phenol, repellent responses to Ni2+ and Co2+, and thermoresponses. These...; Region: TarH; cl00144 114615003053 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 114615003054 Taxis toward Aspartate and Related amino acids and Homologs (TarH). The Tar chemoreceptor of Escherichia coli mediates attractant responses to aspartate, maltose, and phenol, repellent responses to Ni2+ and Co2+, and thermoresponses. These...; Region: TarH; cl00144 114615003055 Domain of unknown function DUF28; Region: DUF28; cl00361 114615003056 Holliday junction resolvases (HJRs) are endonucleases that specifically resolve Holliday junction DNA intermediates during homologous recombination. HJR's occur in archaea, bacteria, and in the mitochondria of certain fungi, however this CD includes...; Region: RuvC_resolvase; cd00529 114615003057 active site 114615003058 putative DNA-binding cleft [nucleotide binding]; other site 114615003059 dimer interface [polypeptide binding]; other site 114615003060 Holliday junction DNA helicase RuvA; Reviewed; Region: ruvA; PRK00116 114615003061 RuvA N terminal domain; Region: RuvA_N; pfam01330 114615003062 Cytidine deaminase zinc-binding domain. These enzymes are Zn dependent. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a water molecule to form a hydroxide ion that performs a nucleophilic attack on...; Region: cytidine_deaminase; cd01283 114615003063 active site 114615003064 catalytic motif [active] 114615003065 Zn binding site [ion binding]; other site 114615003066 Holliday junction DNA helicase RuvB; Reviewed; Region: ruvB; PRK00080 114615003067 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes...; Region: AAA; cd00009 114615003068 Walker A motif; other site 114615003069 ATP binding site [chemical binding]; other site 114615003070 Walker B motif; other site 114615003071 arginine finger; other site 114615003072 Holliday junction DNA helicase ruvB C-terminus; Region: RuvB_C; pfam05491 114615003073 Bacillus subtilis YkuE and related proteins, C-terminal metallophosphatase domain; Region: MPP_YkuE_C; cd07385 114615003074 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 114615003075 putative active site [active] 114615003076 putative metal binding site [ion binding]; other site 114615003077 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active...; Region: 4HBT; cd00586 114615003078 active site 114615003079 DNA helicase, putative; Region: TIGR00376 114615003080 Superfamily I DNA and RNA helicases and helicase subunits [DNA replication, recombination, and repair]; Region: COG1112 114615003081 Superfamily of nucleases including Short Patch Repair (Vsr) Endonucleases, archaeal Holliday junction resolvases, MutH methy-directed DNA mismatch-repair endonucleases, and catalytic domains of many restriction endonucleases, such as EcoRI, BamHI, and...; Region: Restriction_endonuclease_like; cl00277 114615003082 putative active site [active] 114615003083 Protein of unknown function (DUF3320); Region: DUF3320; pfam11784 114615003084 glutathionine S-transferase; Provisional; Region: PRK10542 114615003085 GST_N family, Class Beta subfamily; GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of endogenous and xenobiotic alkylating agents, including carcinogens...; Region: GST_N_Beta; cd03057 114615003086 C-terminal domain interface [polypeptide binding]; other site 114615003087 GSH binding site (G-site) [chemical binding]; other site 114615003088 dimer interface [polypeptide binding]; other site 114615003089 C-terminal, alpha helical domain of Class Beta Glutathione S-transferases; Region: GST_C_Beta; cd03188 114615003090 dimer interface [polypeptide binding]; other site 114615003091 N-terminal domain interface [polypeptide binding]; other site 114615003092 substrate binding pocket (H-site) [chemical binding]; other site 114615003093 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 114615003094 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 114615003095 Phosphoglycerate dehydrogenase and related dehydrogenases [Amino acid transport and metabolism]; Region: SerA; COG0111 114615003096 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 114615003097 YCII-related domain; Region: YCII; cl00999 114615003098 Predicted RNA polymerase sigma factor containing a TPR repeat domain [Transcription]; Region: COG4941 114615003099 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 114615003100 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl15258 114615003101 Escherichia coli PhnB and similar proteins; the E. coli phnB gene is found next to an operon involved in the cleavage of carbon-phosphorus bonds in unactivated alkylphosphonates; Region: PhnB_like; cd06588 114615003102 dimer interface [polypeptide binding]; other site 114615003103 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 114615003104 classical (c) SDRs; Region: SDR_c; cd05233 114615003105 NAD(P) binding site [chemical binding]; other site 114615003106 active site 114615003107 alpha-ketoglutarate decarboxylase; Reviewed; Region: kgd; PRK12270 114615003108 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 114615003109 Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5,10-...; Region: DHFR; cl00161 114615003110 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 114615003111 Glutathione S-transferase (GST) family, N-terminal domain; a large, diverse group of cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of endogenous and xenobiotic...; Region: GST_N_family; cd00570 114615003112 C-terminal domain interface [polypeptide binding]; other site 114615003113 GSH binding site (G-site) [chemical binding]; other site 114615003114 dimer interface [polypeptide binding]; other site 114615003115 C-terminal, alpha helical domain of the Glutathione S-transferase family; Region: GST_C_family; cl02776 114615003116 N-terminal domain interface [polypeptide binding]; other site 114615003117 YCII-related domain; Region: YCII; cl00999 114615003118 YCII-related domain; Region: YCII; cl00999 114615003119 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 114615003120 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 114615003121 Protein of unknown function (DUF2852); Region: DUF2852; pfam11014 114615003122 MotA/TolQ/ExbB proton channel family; Region: MotA_ExbB; cl00568 114615003123 Biopolymer transport proteins [Intracellular trafficking and secretion]; Region: TolQ; COG0811 114615003124 Biopolymer transport protein ExbD/TolR; Region: ExbD; cl00537 114615003125 TolB amino-terminal domain; Region: TolB_N; pfam04052 114615003126 translocation protein TolB; Provisional; Region: tolB; PRK05137 114615003127 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 114615003128 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 114615003129 PAS fold; Region: PAS_7; pfam12860 114615003130 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 114615003131 metal binding site [ion binding]; metal-binding site 114615003132 active site 114615003133 I-site; other site 114615003134 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 114615003135 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 114615003136 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 114615003137 ligand binding site [chemical binding]; other site 114615003138 tol-pal system protein YbgF; Region: tol_pal_ybgF; TIGR02795 114615003139 N-terminal domain of predicted ATPase of the PP-loop faimly implicated in cell cycle control [Cell division and chromosome partitioning]. This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases...; Region: PP-ATPase; cd01992 114615003140 Ligand Binding Site [chemical binding]; other site 114615003141 FtsH Extracellular; Region: FtsH_ext; pfam06480 114615003142 ATP-dependent metalloprotease FtsH; Region: FtsH_fam; TIGR01241 114615003143 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes...; Region: AAA; cd00009 114615003144 Walker A motif; other site 114615003145 ATP binding site [chemical binding]; other site 114615003146 Walker B motif; other site 114615003147 arginine finger; other site 114615003148 Peptidase family M41; Region: Peptidase_M41; pfam01434 114615003149 Autotransporter beta-domain; Region: Autotransporter; cl02365 114615003150 Protein of unknown function (DUF2029); Region: DUF2029; cl09812 114615003151 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 114615003152 Protein of unknown function (DUF2029); Region: DUF2029; cl09812 114615003153 pyruvate kinase; Provisional; Region: PRK06247 114615003154 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl09155 114615003155 domain interfaces; other site 114615003156 active site 114615003157 Protein of unknown function (DUF1036); Region: DUF1036; cl02296 114615003158 Protein of unknown function (DUF1244); Region: DUF1244; cl01385 114615003159 Uncharacterized protein conserved in bacteria (DUF2312); Region: DUF2312; cl11480 114615003160 Peptidase M15; Region: Peptidase_M15_3; cl01194 114615003161 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2989 114615003162 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 114615003163 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204 114615003164 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156 114615003165 active site 114615003166 phosphorylation site [posttranslational modification] 114615003167 intermolecular recognition site; other site 114615003168 dimerization interface [polypeptide binding]; other site 114615003169 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes...; Region: AAA; cd00009 114615003170 Walker A motif; other site 114615003171 ATP binding site [chemical binding]; other site 114615003172 Walker B motif; other site 114615003173 arginine finger; other site 114615003174 Bacterial regulatory protein, Fis family; Region: HTH_8; cl01091 114615003175 oligoendopeptidase, pepF/M3 family; Region: M3_fam_3; TIGR02290 114615003176 Peptidase family M3B Oligopeptidase F (PepF); Region: M3B_PepF_5; cd09610 114615003177 active site 114615003178 Zn binding site [ion binding]; other site 114615003179 SpoVT / AbrB like domain; Region: SpoVT_AbrB; cl00877 114615003180 Fic/DOC family; Region: Fic; cl00960 114615003181 Bacterial aa3 type cytochrome c oxidase subunit IV; Region: COX4_pro_2; pfam07835 114615003182 NAD/NADP transhydrogenase alpha subunit [Energy production and conversion]; Region: PntA; COG3288 114615003183 Alanine dehydrogenase/PNT, N-terminal domain; Region: AlaDh_PNT_N; pfam05222 114615003184 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl14614 114615003185 Domain of unknown function (DUF3814); Region: DUF3814; pfam12769 114615003186 NAD(P) transhydrogenase beta subunit; Region: PNTB; cl00566 114615003187 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 114615003188 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cd00625 114615003189 transmembrane helices; other site 114615003190 calcium/sodium:proton antiporter; Provisional; Region: PRK10599 114615003191 Ribosomal protein S21; Region: Ribosomal_S21; cl00529 114615003192 phosphoribosylaminoimidazole carboxylase ATPase subunit; Reviewed; Region: PRK06019 114615003193 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; cl03087 114615003194 AIR carboxylase; Region: AIRC; cl00310 114615003195 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 114615003196 metal binding site [ion binding]; metal-binding site 114615003197 active site 114615003198 I-site; other site 114615003199 FAD dependent oxidoreductase; Region: DAO; pfam01266 114615003200 Malate:quinone oxidoreductase (Mqo); Region: Mqo; cl14881 114615003201 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459 114615003202 PAS fold; Region: PAS_7; pfam12860 114615003203 PAS fold; Region: PAS_4; pfam08448 114615003204 PAS fold; Region: PAS_4; pfam08448 114615003205 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 114615003206 putative active site [active] 114615003207 heme pocket [chemical binding]; other site 114615003208 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 114615003209 metal binding site [ion binding]; metal-binding site 114615003210 active site 114615003211 I-site; other site 114615003212 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 114615003213 glycerol-3-phosphate dehydrogenase; Provisional; Region: PRK13369 114615003214 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 114615003215 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 114615003216 PotA is an ABC-type transporter and the ATPase component of the spermidine/putrescine-preferential uptake system consisting of PotA, -B, -C, and -D. PotA has two domains with the N-terminal domain containing the ATPase activity and the residues...; Region: ABC_PotA_N; cd03300 114615003217 Walker A/P-loop; other site 114615003218 ATP binding site [chemical binding]; other site 114615003219 Q-loop/lid; other site 114615003220 ABC transporter signature motif; other site 114615003221 Walker B; other site 114615003222 D-loop; other site 114615003223 H-loop/switch region; other site 114615003224 TOBE domain; Region: TOBE_2; cl01440 114615003225 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261 114615003226 dimer interface [polypeptide binding]; other site 114615003227 conserved gate region; other site 114615003228 putative PBP binding loops; other site 114615003229 ABC-ATPase subunit interface; other site 114615003230 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261 114615003231 dimer interface [polypeptide binding]; other site 114615003232 conserved gate region; other site 114615003233 putative PBP binding loops; other site 114615003234 ABC-ATPase subunit interface; other site 114615003235 Predicted dienelactone hydrolase [General function prediction only]; Region: COG4188 114615003236 isoform II; Region: PAF-AH_p_II; pfam03403 114615003237 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 114615003238 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261 114615003239 dimer interface [polypeptide binding]; other site 114615003240 conserved gate region; other site 114615003241 putative PBP binding loops; other site 114615003242 ABC-ATPase subunit interface; other site 114615003243 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cl00427 114615003244 ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555 114615003245 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 114615003246 Uncharacterized protein involved in outer membrane biogenesis [Cell envelope biogenesis, outer membrane]; Region: AsmA; COG2982 114615003247 SugarP_isomerase: Sugar Phosphate Isomerase family; includes type A ribose 5-phosphate isomerase (RPI_A), glucosamine-6-phosphate (GlcN6P) deaminase, and 6-phosphogluconolactonase (6PGL). RPI catalyzes the reversible conversion of ribose-5-phosphate to...; Region: SugarP_isomerase; cl00339 114615003248 SugarP_isomerase: Sugar Phosphate Isomerase family; includes type A ribose 5-phosphate isomerase (RPI_A), glucosamine-6-phosphate (GlcN6P) deaminase, and 6-phosphogluconolactonase (6PGL). RPI catalyzes the reversible conversion of ribose-5-phosphate to...; Region: SugarP_isomerase; cl00339 114615003249 Phosphorylase superfamily; Region: PNP_UDP_1; cl00303 114615003250 Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; cl00556 114615003251 nitrite reductase, copper-containing; Region: Cu_nitrite_red; TIGR02376 114615003252 Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; cl11412 114615003253 Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; cl11412 114615003254 coproporphyrinogen III oxidase; Provisional; Region: PRK09249 114615003255 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster...; Region: Radical_SAM; cd01335 114615003256 FeS/SAM binding site; other site 114615003257 HemN C-terminal region; Region: HemN_C; pfam06969 114615003258 Domain of unknown function (DUF1858); Region: DUF1858; cl14817 114615003259 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 114615003260 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 114615003261 ligand binding site [chemical binding]; other site 114615003262 flexible hinge region; other site 114615003263 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 114615003264 putative switch regulator; other site 114615003265 non-specific DNA interactions [nucleotide binding]; other site 114615003266 DNA binding site [nucleotide binding] 114615003267 sequence specific DNA binding site [nucleotide binding]; other site 114615003268 putative cAMP binding site [chemical binding]; other site 114615003269 NnrS protein; Region: NnrS; cl01258 114615003270 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 114615003271 putative active site [active] 114615003272 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 114615003273 heme pocket [chemical binding]; other site 114615003274 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via trans-...; Region: HisKA; cd00082 114615003275 dimer interface [polypeptide binding]; other site 114615003276 phosphorylation site [posttranslational modification] 114615003277 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 114615003278 ATP binding site [chemical binding]; other site 114615003279 Mg2+ binding site [ion binding]; other site 114615003280 G-X-G motif; other site 114615003281 Phasin protein; Region: Phasin_2; cl11491 114615003282 Phasin protein; Region: Phasin_2; cl11491 114615003283 conjugal transfer relaxase TraA; Provisional; Region: PRK13889 114615003284 MobA/MobL family; Region: MobA_MobL; pfam03389 114615003285 Helicase; Region: Herpes_Helicase; pfam02689 114615003286 Conjugal transfer protein TraD; Region: TraD; cl05753 114615003287 Caspase, interleukin-1 beta converting enzyme (ICE) homologues; Cysteine-dependent aspartate-directed proteases that mediate programmed cell death (apoptosis). Caspases are synthesized as inactive zymogens and activated by proteolysis of the peptide...; Region: CASc; cl00042 114615003288 Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cl10459 114615003289 active site 114615003290 catalytic residues [active] 114615003291 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 114615003292 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 114615003293 Q-loop/lid; other site 114615003294 ABC transporter signature motif; other site 114615003295 Predicted ATP-dependent endonuclease of the OLD family [DNA replication, recombination, and repair]; Region: COG3593 114615003296 Walker B; other site 114615003297 D-loop; other site 114615003298 H-loop/switch region; other site 114615003299 UvrD/REP helicase; Region: UvrD-helicase; cl14126 114615003300 Superfamily I DNA and RNA helicases [DNA replication, recombination, and repair]; Region: UvrD; COG0210 114615003301 Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cl10459 114615003302 active site 114615003303 catalytic residues [active] 114615003304 PAP2_like proteins, a super-family of histidine phosphatases and vanadium haloperoxidases, includes type 2 phosphatidic acid phosphatase or lipid phosphate phosphatase (LPP), Glucose-6-phosphatase, Phosphatidylglycerophosphatase B and bacterial acid...; Region: PAP2_like; cl00474 114615003305 active site 114615003306 Curli production assembly/transport component CsgG; Region: CsgG; cl00639 114615003307 FOG: TPR repeat [General function prediction only]; Region: NrfG; COG0457 114615003308 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi...; Region: TPR; cd00189 114615003309 TPR motif; other site 114615003310 binding surface 114615003311 Zinc-dependent metalloprotease, MMP_like subfamily. This group contains matrix metalloproteinases (MMPs), serralysins, and the astacin_like family of proteases; Region: ZnMc_MMP_like; cd04268 114615003312 active site 114615003313 Dyp-type peroxidase family; Region: Dyp_perox; cl01067 114615003314 PAP2, haloperoxidase_like subfamily. Haloperoxidases catalyze the oxidation of halides such as bromide or chloride by hydrogen peroxide, which results in subsequent halogenation of organic substrates, or halide-assisted disproportionation of hydrogen...; Region: PAP2_haloperoxidase; cd03398 114615003315 active site 114615003316 Bacteriophage P4 integrase. P4-like integrases are found in temperate bacteriophages, integrative plasmids, pathogenicity and symbiosis islands, and other mobile genetic elements. They share the same fold in their catalytic domain and the overall...; Region: INT_P4; cd00801 114615003317 Phage integrase family; Region: Phage_integrase; pfam00589 114615003318 active site 114615003319 Int/Topo IB signature motif; other site 114615003320 FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202 114615003321 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 114615003322 putative active site [active] 114615003323 heme pocket [chemical binding]; other site 114615003324 FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202 114615003325 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 114615003326 putative active site [active] 114615003327 heme pocket [chemical binding]; other site 114615003328 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 114615003329 putative active site [active] 114615003330 heme pocket [chemical binding]; other site 114615003331 Taxis toward Aspartate and Related amino acids and Homologs (TarH). The Tar chemoreceptor of Escherichia coli mediates attractant responses to aspartate, maltose, and phenol, repellent responses to Ni2+ and Co2+, and thermoresponses. These...; Region: TarH; cl00144 114615003332 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 114615003333 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors...; Region: LuxR_C_like; cd06170 114615003334 DNA binding residues [nucleotide binding] 114615003335 dimerization interface [polypeptide binding]; other site 114615003336 Bacteriophytochrome (light-regulated signal transduction histidine kinase) [Signal transduction mechanisms]; Region: COG4251 114615003337 GAF domain; Region: GAF; cl00853 114615003338 Phytochrome region; Region: PHY; pfam00360 114615003339 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 114615003340 anti sigma factor interaction site; other site 114615003341 regulatory phosphorylation site [posttranslational modification]; other site 114615003342 Heme oxygenase catalyzes the rate limiting step in the degradation of heme to bilirubin, it is essential for recycling of iron from heme. Heme is used as a substrate and cofactor for its own degradation to biliverdin, iron, and carbon monoxide. This...; Region: HemeO; cl15243 114615003343 heme ligand [chemical binding]; other site 114615003344 Heme oxygenase catalyzes the rate limiting step in the degradation of heme to bilirubin, it is essential for recycling of iron from heme. Heme is used as a substrate and cofactor for its own degradation to biliverdin, iron, and carbon monoxide. This...; Region: HemeO; cl15243 114615003345 heme binding pocket [chemical binding]; other site 114615003346 Ferredoxin-dependent bilin reductase; Region: Fe_bilin_red; cl07930 114615003347 7-keto-8-aminopelargonate synthetase and related enzymes [Coenzyme metabolism]; Region: BioF; COG0156 114615003348 KBL_like; this family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to serine palmitoyltransferase (SPT), 5-aminolevulinate synthase (ALAS), 8-amino-7-...; Region: KBL_like; cd06454 114615003349 substrate-cofactor binding pocket; other site 114615003350 pyridoxal 5'-phosphate binding site [chemical binding]; other site 114615003351 catalytic residue [active] 114615003352 gas vesicle protein GvpN; Region: gas_vesic_GvpN; TIGR02640 114615003353 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes...; Region: AAA; cd00009 114615003354 Walker A motif; other site 114615003355 ATP binding site [chemical binding]; other site 114615003356 Walker B motif; other site 114615003357 arginine finger; other site 114615003358 Gas vesicle synthesis protein GvpO; Region: GvpO; pfam05800 114615003359 Gas vesicle protein; Region: Gas_vesicle; cl02954 114615003360 This domain family includes the alpha-crystallin domain (ACD) of alpha-crystallin-type small heat shock proteins (sHsps) and a similar domain found in p23-like proteins. sHsps are small stress induced proteins with monomeric masses between 12 -43 kDa...; Region: ACD_sHsps_p23-like; cd00298 114615003361 Gas vesicle synthesis protein GvpL/GvpF; Region: GvpL_GvpF; pfam06386 114615003362 Gas vesicle protein G; Region: GvpG; pfam05120 114615003363 Cell division protein 48 (CDC48), N-terminal domain; Region: CDC48_N; cl08347 114615003364 AAA family ATPase, CDC48 subfamily; Region: CDC48; TIGR01243 114615003365 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes...; Region: AAA; cd00009 114615003366 Walker A motif; other site 114615003367 ATP binding site [chemical binding]; other site 114615003368 Walker B motif; other site 114615003369 arginine finger; other site 114615003370 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes...; Region: AAA; cd00009 114615003371 Walker A motif; other site 114615003372 ATP binding site [chemical binding]; other site 114615003373 Walker B motif; other site 114615003374 arginine finger; other site 114615003375 Gas vesicle synthesis protein GvpL/GvpF; Region: GvpL_GvpF; pfam06386 114615003376 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of...; Region: DnaJ; cl02542 114615003377 Gas vesicle synthesis protein GvpL/GvpF; Region: GvpL_GvpF; pfam06386 114615003378 Gas vesicle protein; Region: Gas_vesicle; cl02954 114615003379 Gas vesicle protein K; Region: GvpK; pfam05121 114615003380 chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168 114615003381 Gas vesicle protein; Region: Gas_vesicle; cl02954 114615003382 Y-family of DNA polymerases; Region: PolY; cl12025 114615003383 Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; cl00556 114615003384 general secretion pathway protein D; Region: type_II_gspD; TIGR02517 114615003385 Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958 114615003386 Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958 114615003387 Bacterial type II and III secretion system protein; Region: Secretin; cl02829 114615003388 FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790 114615003389 Sel1 repeat; Region: Sel1; cl02723 114615003390 GSPII_E N-terminal domain; Region: GSPII_E_N; pfam05157 114615003391 general secretory pathway protein E; Region: type_II_gspE; TIGR02533 114615003392 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 114615003393 Walker A motif; other site 114615003394 ATP binding site [chemical binding]; other site 114615003395 Walker B motif; other site 114615003396 Type II secretory pathway, component PulF [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulF; COG1459 114615003397 Bacterial type II secretion system protein F domain; Region: GSPII_F; cl00906 114615003398 Bacterial type II secretion system protein F domain; Region: GSPII_F; cl00906 114615003399 general secretion pathway protein G; Region: typeII_sec_gspG; TIGR01710 114615003400 Bacterial type II secretion system protein G; Region: GSPII_G; pfam08334 114615003401 General secretion pathway protein K; Region: GspK; pfam03934 114615003402 Fimbrial assembly protein (PilN); Region: PilN; pfam05137 114615003403 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 114615003404 General secretion pathway protein M; Region: GspM_II; pfam10741 114615003405 Putative multicopper oxidases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: SufI; COG2132 114615003406 Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; cl11412 114615003407 Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; cl11412 114615003408 FMN-binding domain; Region: FMN_bind; cl01081 114615003409 ApbE family; Region: ApbE; cl00643 114615003410 SAM-dependent methyltransferases [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: SmtA; COG0500 114615003411 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cl12011 114615003412 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cd02440 114615003413 S-adenosylmethionine binding site [chemical binding]; other site 114615003414 Toxic anion resistance protein (TelA); Region: TelA; pfam05816 114615003415 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198 114615003416 metal ion-dependent adhesion site (MIDAS); other site 114615003417 5-bromo-4-chloroindolyl phosphate hydrolysis protein; Region: Halogen_Hydrol; cl02059 114615003418 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following...; Region: ParA; cd02042 114615003419 P-loop; other site 114615003420 Magnesium ion binding site [ion binding]; other site 114615003421 Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329 114615003422 Dihydrodipicolinate synthase (DHDPS); Region: DHDPS; cd00950 114615003423 dimer interface [polypeptide binding]; other site 114615003424 active site 114615003425 catalytic residue [active] 114615003426 Transcriptional regulator [Transcription]; Region: LysR; COG0583 114615003427 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 114615003428 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 114615003429 putative effector binding pocket; other site 114615003430 dimerization interface [polypeptide binding]; other site 114615003431 thioredoxin-disulfide reductase; Region: TRX_reduct; TIGR01292 114615003432 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 114615003433 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 114615003434 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 114615003435 putative DNA binding site [nucleotide binding]; other site 114615003436 putative Zn2+ binding site [ion binding]; other site 114615003437 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 114615003438 DoxX; Region: DoxX; cl00976 114615003439 transcription elongation factor GreA; Reviewed; Region: greA; PRK00226 114615003440 domain; Region: GreA_GreB_N; pfam03449 114615003441 C-term; Region: GreA_GreB; pfam01272 114615003442 carbamoyl phosphate synthase large subunit; Reviewed; Region: carB; PRK05294 114615003443 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 114615003444 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; cl03087 114615003445 Carbamoyl-phosphate synthetase large chain, oligomerisation domain; Region: CPSase_L_D3; pfam02787 114615003446 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 114615003447 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; cl03087 114615003448 Methylglyoxal synthase-like domain from type II glutamine-dependent carbamoyl phosphate synthetase (CSP). CSP, a CarA and CarB heterodimer, catalyzes the production of carbamoyl phosphate which is subsequently employed in the metabolic pathways...; Region: MGS_CPS_II; cd01424 114615003449 IMP binding site; other site 114615003450 dimer interface [polypeptide binding]; other site 114615003451 interdomain contacts; other site 114615003452 partial ornithine binding site; other site 114615003453 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 114615003454 putative substrate translocation pore; other site 114615003455 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 114615003456 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cl12011 114615003457 DPS protein, ferritin-like diiron-binding domain; Region: DPS; cd01043 114615003458 Ferritin-like domain; Region: Ferritin; pfam00210 114615003459 dimerization interface [polypeptide binding]; other site 114615003460 DPS ferroxidase diiron center [ion binding]; other site 114615003461 ion pore; other site 114615003462 YeeE/YedE family (DUF395); Region: DUF395; cl01018 114615003463 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 114615003464 dimerization interface [polypeptide binding]; other site 114615003465 putative DNA binding site [nucleotide binding]; other site 114615003466 putative Zn2+ binding site [ion binding]; other site 114615003467 Cupin domain; Region: Cupin_2; cl09118 114615003468 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_16; cd08502 114615003469 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 114615003470 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 114615003471 CoenzymeA binding site [chemical binding]; other site 114615003472 subunit interaction site [polypeptide binding]; other site 114615003473 PHB binding site; other site 114615003474 carbamoyl phosphate synthase small subunit; Reviewed; Region: PRK12564 114615003475 Carbamoyl-phosphate synthase small chain, CPSase domain; Region: CPSase_sm_chain; cl03056 114615003476 Small chain of the glutamine-dependent form of carbamoyl phosphate synthase, CPSase II; Region: GATase1_CPSase; cd01744 114615003477 catalytic site [active] 114615003478 subunit interface [polypeptide binding]; other site 114615003479 GatB domain; Region: GatB_Yqey; cl11497 114615003480 Acyl-coenzyme A synthetases/AMP-(fatty) acid ligases [Lipid metabolism]; Region: Acs; COG0365 114615003481 Acyl-protein synthetase, LuxE; Region: LuxE; cl10450 114615003482 Predicted integral membrane protein (DUF2189); Region: DUF2189; cl02291 114615003483 Putative hydrophobic ligand-binding SRPBCC domain of an uncharacterized subgroup of CalC- and Aha1-like proteins; some contain an N-terminal GntR family winged HTH DNA-binding domain; Region: SRPBCC_CalC_Aha1-like_GntR-HTH; cd08893 114615003484 putative hydrophobic ligand binding site [chemical binding]; other site 114615003485 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 114615003486 dimerization interface [polypeptide binding]; other site 114615003487 putative DNA binding site [nucleotide binding]; other site 114615003488 putative Zn2+ binding site [ion binding]; other site 114615003489 LysE type translocator; Region: LysE; cl00565 114615003490 Predicted epimerase, PhzC/PhzF homolog [General function prediction only]; Region: COG0384 114615003491 Diaminopimelate epimerase; Region: DAP_epimerase; cl14668 114615003492 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 114615003493 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 114615003494 DNA-binding site [nucleotide binding]; DNA binding site 114615003495 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 114615003496 pyridoxal 5'-phosphate binding site [chemical binding]; other site 114615003497 homodimer interface [polypeptide binding]; other site 114615003498 catalytic residue [active] 114615003499 N-formylglutamate amidohydrolase; Region: FGase; cl01522 114615003500 Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305 114615003501 Transglutaminase-like superfamily; Region: Transglut_core; cl10469 114615003502 GGCT-like domains, also called AIG2-like family. Gamma-glutamyl cyclotransferase (GGCT) catalyzes the formation of pyroglutamic acid (5-oxoproline) from dipeptides containing gamma-glutamyl, and is a dimeric protein. In Homo sapiens, the protein is...; Region: GGCT_like; cd06661 114615003503 putative active site pocket [active] 114615003504 dimerization interface [polypeptide binding]; other site 114615003505 putative catalytic residue [active] 114615003506 DNA primase; Validated; Region: dnaG; PRK05667 114615003507 CHC2 zinc finger; Region: zf-CHC2; cl02597 114615003508 DNA primase catalytic core, N-terminal domain; Region: Toprim_N; pfam08275 114615003509 TOPRIM_DnaG_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of proteins similar to Escherichia coli DnaG. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_DnaG_primases; cd03364 114615003510 active site 114615003511 metal binding site [ion binding]; metal-binding site 114615003512 interdomain interaction site; other site 114615003513 DnaB-helicase binding domain of primase; Region: DnaB_bind; pfam10410 114615003514 RNA polymerase sigma factor RpoD; Validated; Region: PRK05658 114615003515 Sigma-70 factor, region 1.1; Region: Sigma70_r1_1; pfam03979 114615003516 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 114615003517 Sigma-70, non-essential region; Region: Sigma70_ner; pfam04546 114615003518 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 114615003519 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 114615003520 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial...; Region: Sigma70_r4; cd06171 114615003521 DNA binding residues [nucleotide binding] 114615003522 Protein of unknown function (DUF817); Region: DUF817; cl01520 114615003523 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi...; Region: TPR; cd00189 114615003524 binding surface 114615003525 TPR motif; other site 114615003526 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi...; Region: TPR; cd00189 114615003527 binding surface 114615003528 TPR motif; other site 114615003529 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi...; Region: TPR; cd00189 114615003530 binding surface 114615003531 TPR motif; other site 114615003532 Predicted O-linked N-acetylglucosamine transferase, SPINDLY family [Posttranslational modification, protein turnover, chaperones]; Region: Spy; COG3914 114615003533 Protein of unknown function, DUF393; Region: DUF393; cl01136 114615003534 lysozyme_like domain. This contains several members including Soluble Lytic Transglycosylases (SLT), Goose Egg-White Lysozymes (GEWL), Hen Egg-White Lysozymes (HEWL), chitinases, bacteriophage lambda lysozymes, endolysins, autolysins, and chitosanases...; Region: lysozyme_like; cl00222 114615003535 short chain dehydrogenase; Provisional; Region: PRK06181 114615003536 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 114615003537 NAD(P) binding site [chemical binding]; other site 114615003538 active site 114615003539 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156 114615003540 active site 114615003541 phosphorylation site [posttranslational modification] 114615003542 intermolecular recognition site; other site 114615003543 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 114615003544 metal binding site [ion binding]; metal-binding site 114615003545 active site 114615003546 I-site; other site 114615003547 Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583 114615003548 amidase catalytic site [active] 114615003549 Zn binding residues [ion binding]; other site 114615003550 substrate binding site [chemical binding]; other site 114615003551 RNA polymerase factor sigma-32; Reviewed; Region: PRK06596 114615003552 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 114615003553 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 114615003554 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial...; Region: Sigma70_r4; cd06171 114615003555 DNA binding residues [nucleotide binding] 114615003556 pseudouridine synthase, RluA family; Region: rluA_subfam; TIGR00005 114615003557 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 114615003558 RNA binding surface [nucleotide binding]; other site 114615003559 PseudoU_synth_RsuA/RluD: Pseudouridine synthase, RsuA/RluD family. This group is comprised of eukaryotic, bacterial and archeal proteins similar to eight site specific Escherichia coli pseudouridine synthases: RsuA, RluA, RluB, RluC, RluD, RluE, RluF...; Region: PseudoU_synth_RluCD_like; cd02869 114615003560 active site 114615003561 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cl12011 114615003562 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cl12011 114615003563 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 114615003564 ATP binding site [chemical binding]; other site 114615003565 putative Mg++ binding site [ion binding]; other site 114615003566 Cytochrome P450; Region: p450; cl12078 114615003567 ParB-like nuclease domain; Region: ParBc; cl02129 114615003568 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 114615003569 Catalase-like heme-binding proteins similar to the uncharacterized srpA; Region: srpA_like; cd08153 114615003570 putative heme binding pocket [chemical binding]; other site 114615003571 Surface antigen; Region: Surface_Ag_2; cl01155 114615003572 Protein of unknown function (DUF3160); Region: DUF3160; pfam11369 114615003573 Bacterial capsule synthesis protein PGA_cap; Region: PGA_cap; smart00854 114615003574 CapA and related proteins, metallophosphatase domain; Region: MPP_CapA; cd07381 114615003575 putative active site [active] 114615003576 putative metal binding site [ion binding]; other site 114615003577 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 114615003578 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 114615003579 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; cl11611 114615003580 Dehydroquinase (DHQase), type II. Dehydroquinase (or 3-dehydroquinate dehydratase) catalyzes the reversible dehydration of 3-dehydroquinate to form 3-dehydroshikimate. This reaction is part of two metabolic pathways: the biosynthetic shikimate pathway...; Region: DHQase_II; cd00466 114615003581 trimer interface [polypeptide binding]; other site 114615003582 active site 114615003583 dimer interface [polypeptide binding]; other site 114615003584 GAF domain; Region: GAF; cl00853 114615003585 Bacterial regulatory protein, Fis family; Region: HTH_8; cl01091 114615003586 Ralstonia eutrophus NAD+-dependent acetaldehyde dehydrogenase II-like; Region: ALDH_ACDHII-AcoD; cd07116 114615003587 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 114615003588 NAD(P) binding site [chemical binding]; other site 114615003589 catalytic residues [active] 114615003590 Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1)...; Region: Rieske; cl00938 114615003591 iron-sulfur cluster [ion binding]; other site 114615003592 [2Fe-2S] cluster binding site [ion binding]; other site 114615003593 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of...; Region: DnaJ; cl02542 114615003594 CRISPR/Cas system-associated protein Cas4; Region: Cas4_I-A_I-B_I-C_I-D_II-B; cl00641 114615003595 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 114615003596 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: RbsB; COG1879 114615003597 Periplasmic sugar-binding domain of uncharacterized ABC-type transport systems; Region: PBP1_ABC_sugar_binding_like_11; cd06321 114615003598 putative ligand binding site [chemical binding]; other site 114615003599 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 114615003600 TM-ABC transporter signature motif; other site 114615003601 ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129 114615003602 This family represents the domain I of the carbohydrate uptake proteins that transport only monosaccharides (Monos). The Carb_Monos family is involved in the uptake of monosaccharides, such as pentoses (such as xylose, arabinose, and ribose) and...; Region: ABC_Carb_Monos_I; cd03216 114615003603 Walker A/P-loop; other site 114615003604 ATP binding site [chemical binding]; other site 114615003605 Q-loop/lid; other site 114615003606 ABC transporter signature motif; other site 114615003607 Walker B; other site 114615003608 D-loop; other site 114615003609 H-loop/switch region; other site 114615003610 This family represents domain II of the carbohydrate uptake proteins that transport only monosaccharides (Monos). The Carb_Monos family is involved in the uptake of monosaccharides, such as pentoses (such as xylose, arabinose, and ribose) and hexoses (; Region: ABC_Carb_Monos_II; cd03215 114615003611 Sugar (pentulose and hexulose) kinases [Carbohydrate transport and metabolism]; Region: XylB; COG1070 114615003612 D-xylulose kinases, Escherichia coli xylulokinase-like subgroup; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_D-XK_EcXK-like; cd07808 114615003613 N- and C-terminal domain interface [polypeptide binding]; other site 114615003614 active site 114615003615 catalytic site [active] 114615003616 metal binding site [ion binding]; metal-binding site 114615003617 xylulose binding site [chemical binding]; other site 114615003618 putative ATP binding site [chemical binding]; other site 114615003619 homodimer interface [polypeptide binding]; other site 114615003620 glucose-1-dehydrogenase; Provisional; Region: PRK08936 114615003621 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 114615003622 NAD(P) binding site [chemical binding]; other site 114615003623 active site 114615003624 Protein of unknown function (DUF1446); Region: DUF1446; pfam07287 114615003625 dehydrogenase, Rv0697 family; Region: Rv0697; TIGR03970 114615003626 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 114615003627 Gamma-glutamyltransferase [Amino acid transport and metabolism]; Region: Ggt; cl08040 114615003628 Gamma-glutamyltranspeptidase; Region: G_glu_transpept; pfam01019 114615003629 D-glutamate deacylase; Validated; Region: PRK09061 114615003630 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have...; Region: metallo-dependent_hydrolases; cl00281 114615003631 active site 114615003632 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have...; Region: metallo-dependent_hydrolases; cl00281 114615003633 Putative GTPases (G3E family) [General function prediction only]; Region: COG0523 114615003634 Ras-like GTPase superfamily. The Ras-like superfamily of small GTPases consists of several families with an extremely high degree of structural and functional similarity. The Ras superfamily is divided into at least four families in eukaryotes: the Ras...; Region: Ras_like_GTPase; cl10444 114615003635 Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; cl08458 114615003636 diguanylate cyclase AdrA; Provisional; Region: adrA; PRK10245 114615003637 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 114615003638 metal binding site [ion binding]; metal-binding site 114615003639 active site 114615003640 I-site; other site 114615003641 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of...; Region: DnaJ; cd06257 114615003642 HSP70 interaction site [polypeptide binding]; other site 114615003643 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi...; Region: TPR; cd00189 114615003644 binding surface 114615003645 TPR motif; other site 114615003646 Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329 114615003647 Dihydrodipicolinate synthase family; Region: DHDPS-like; cd00408 114615003648 inhibitor site; inhibition site 114615003649 active site 114615003650 dimer interface [polypeptide binding]; other site 114615003651 catalytic residue [active] 114615003652 Aerobic-type carbon monoxide dehydrogenase, large subunit CoxL/CutL homologs [Energy production and conversion]; Region: CoxL; COG1529 114615003653 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; cl03161 114615003654 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 114615003655 Two-component sensor kinase N-terminal; Region: 2CSK_N; pfam08521 114615003656 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 114615003657 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via trans-...; Region: HisKA; cd00082 114615003658 dimer interface [polypeptide binding]; other site 114615003659 phosphorylation site [posttranslational modification] 114615003660 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 114615003661 ATP binding site [chemical binding]; other site 114615003662 G-X-G motif; other site 114615003663 transcriptional regulatory protein TctD; Provisional; Region: PRK15479 114615003664 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156 114615003665 active site 114615003666 phosphorylation site [posttranslational modification] 114615003667 intermolecular recognition site; other site 114615003668 dimerization interface [polypeptide binding]; other site 114615003669 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase...; Region: trans_reg_C; cd00383 114615003670 DNA binding site [nucleotide binding] 114615003671 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 114615003672 NrtD and SsuB are the ATP-binding subunits of the bacterial ABC-type nitrate and sulfonate transport systems, respectively. ABC transporters are a large family of proteins involved in the transport of a wide variety of different compounds, like sugars...; Region: ABC_NrtD_SsuB_transporters; cd03293 114615003673 Walker A/P-loop; other site 114615003674 ATP binding site [chemical binding]; other site 114615003675 Q-loop/lid; other site 114615003676 ABC transporter signature motif; other site 114615003677 Walker B; other site 114615003678 D-loop; other site 114615003679 H-loop/switch region; other site 114615003680 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 114615003681 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cl00427 114615003682 Tripartite tricarboxylate transporter family receptor; Region: TctC; cl15260 114615003683 ABC transporter, substrate-binding protein, aliphatic sulfonates family; Region: SsuA_fam; TIGR01728 114615003684 Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices connected by an extended linker. The...; Region: HAMP; cl01054 114615003685 sensor protein KdpD; Provisional; Region: PRK10490 114615003686 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 114615003687 ATP binding site [chemical binding]; other site 114615003688 Mg2+ binding site [ion binding]; other site 114615003689 G-X-G motif; other site 114615003690 osmolarity response regulator; Provisional; Region: ompR; PRK09468 114615003691 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156 114615003692 active site 114615003693 phosphorylation site [posttranslational modification] 114615003694 intermolecular recognition site; other site 114615003695 dimerization interface [polypeptide binding]; other site 114615003696 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase...; Region: trans_reg_C; cd00383 114615003697 DNA binding site [nucleotide binding] 114615003698 LemA family; Region: LemA; cl00742 114615003699 Domain of unknown function (DUF477); Region: DUF477; cl01535 114615003700 Domain of unknown function (DUF477); Region: DUF477; cl01535 114615003701 Predicted transcriptional regulator [Transcription]; Region: COG2378 114615003702 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 114615003703 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 114615003704 GST_N family, Saccharomyces cerevisiae GTT1-like subfamily; composed of predominantly uncharacterized proteins with similarity to the S. cerevisiae GST protein, GTT1, and the Schizosaccharomyces pombe GST-III. GSTs are cytosolic dimeric proteins...; Region: GST_N_GTT1_like; cd03046 114615003705 putative C-terminal domain interface [polypeptide binding]; other site 114615003706 putative GSH binding site (G-site) [chemical binding]; other site 114615003707 putative dimer interface [polypeptide binding]; other site 114615003708 C-terminal, alpha helical domain of an unknown subfamily 8 of Glutathione S-transferases; Region: GST_C_8; cd03207 114615003709 dimer interface [polypeptide binding]; other site 114615003710 N-terminal domain interface [polypeptide binding]; other site 114615003711 putative substrate binding pocket (H-site) [chemical binding]; other site 114615003712 Predicted acyl esterases [General function prediction only]; Region: COG2936 114615003713 X-Pro dipeptidyl-peptidase C-terminal non-catalytic domain; Region: PepX_C; cl08482 114615003714 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 114615003715 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 114615003716 Protein of unknown function (DUF1493); Region: DUF1493; pfam07377 114615003717 CoA-transferase family III; Region: CoA_transf_3; cl00778 114615003718 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box protein...; Region: CSP_CDS; cd04458 114615003719 DNA-binding site [nucleotide binding]; DNA binding site 114615003720 RNA-binding motif; other site 114615003721 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 114615003722 catalytic loop [active] 114615003723 iron binding site [ion binding]; other site 114615003724 cyclase homology domain; Region: CHD; cd07302 114615003725 nucleotidyl binding site; other site 114615003726 metal binding site [ion binding]; metal-binding site 114615003727 dimer interface [polypeptide binding]; other site 114615003728 4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family [Cell envelope biogenesis, outer membrane]; Region: ArnT; COG1807 114615003729 hypothetical protein; Provisional; Region: PRK05415 114615003730 Domain of unknown function (DUF697); Region: DUF697; cl12064 114615003731 YcjX-like family, DUF463; Region: DUF463; cl01193 114615003732 Haemolysin-III related; Region: HlyIII; cl03831 114615003733 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK05565 114615003734 classical (c) SDRs; Region: SDR_c; cd05233 114615003735 NAD(P) binding site [chemical binding]; other site 114615003736 active site 114615003737 Uncharacterized protein conserved in bacteria (DUF2320); Region: DUF2320; cl12051 114615003738 benzoylformate decarboxylase; Reviewed; Region: PRK07092 114615003739 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 114615003740 PYR/PP interface [polypeptide binding]; other site 114615003741 dimer interface [polypeptide binding]; other site 114615003742 TPP binding site [chemical binding]; other site 114615003743 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 114615003744 TPP-binding module; composed of proteins similar to Pseudomonas putida benzoylformate decarboxylase (BFDC). P. putida BFDC plays a role in the mandelate pathway, catalyzing the conversion of benzoylformate to benzaldehyde and carbon dioxide. This...; Region: TPP_BFDC; cd02002 114615003745 TPP-binding site [chemical binding]; other site 114615003746 dimer interface [polypeptide binding]; other site 114615003747 Uncharacterized conserved protein [Function unknown]; Region: COG3777 114615003748 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 114615003749 active site 2 [active] 114615003750 active site 1 [active] 114615003751 CoA-transferase family III; Region: CoA_transf_3; cl00778 114615003752 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 114615003753 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 114615003754 active site 114615003755 hypothetical protein; Provisional; Region: PRK06163 114615003756 TPP-binding module; composed of proteins similar to Methanococcus jannaschii sulfopyruvate decarboxylase beta subunit (ComE). M. jannaschii sulfopyruvate decarboxylase (ComDE) is a dodecamer of six alpha (D) subunits and six (E) beta subunits, which...; Region: TPP_ComE; cd03372 114615003757 TPP-binding site; other site 114615003758 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 114615003759 PYR/PP interface [polypeptide binding]; other site 114615003760 dimer interface [polypeptide binding]; other site 114615003761 TPP binding site [chemical binding]; other site 114615003762 Cytochrome P450; Region: p450; cl12078 114615003763 Cytochrome P450; Region: p450; cl12078 114615003764 Isovaleryl-CoA dehydrogenase; Region: IVD; cd01156 114615003765 isovaleryl-CoA dehydrogenase; Region: PLN02519 114615003766 substrate binding site [chemical binding]; other site 114615003767 FAD binding site [chemical binding]; other site 114615003768 catalytic base [active] 114615003769 Bacterial protein of unknown function (DUF898); Region: DUF898; cl01738 114615003770 Peptidase family M48; Region: Peptidase_M48; cl12018 114615003771 Protein of unknown function (DUF2927); Region: DUF2927; pfam11150 114615003772 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 114615003773 hypothetical protein; Validated; Region: PRK07586 114615003774 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 114615003775 PYR/PP interface [polypeptide binding]; other site 114615003776 dimer interface [polypeptide binding]; other site 114615003777 TPP binding site [chemical binding]; other site 114615003778 TPP-binding module; composed of proteins similar to Pseudomonas putida benzoylformate decarboxylase (BFDC). P. putida BFDC plays a role in the mandelate pathway, catalyzing the conversion of benzoylformate to benzaldehyde and carbon dioxide. This...; Region: TPP_BFDC; cd02002 114615003779 TPP-binding site [chemical binding]; other site 114615003780 dimer interface [polypeptide binding]; other site 114615003781 Cytochrome c; Region: Cytochrom_C; cl11414 114615003782 Uncharacterized conserved protein [Function unknown]; Region: COG3287 114615003783 FIST N domain; Region: FIST; cl10701 114615003784 FIST C domain; Region: FIST_C; pfam10442 114615003785 Osmosensitive K+ channel histidine kinase [Signal transduction mechanisms]; Region: KdpD; COG2205 114615003786 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 114615003787 ATP binding site [chemical binding]; other site 114615003788 Mg2+ binding site [ion binding]; other site 114615003789 G-X-G motif; other site 114615003790 Response regulator receiver domain; Region: Response_reg; pfam00072 114615003791 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156 114615003792 active site 114615003793 phosphorylation site [posttranslational modification] 114615003794 intermolecular recognition site; other site 114615003795 dimerization interface [polypeptide binding]; other site 114615003796 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 114615003797 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156 114615003798 active site 114615003799 phosphorylation site [posttranslational modification] 114615003800 intermolecular recognition site; other site 114615003801 dimerization interface [polypeptide binding]; other site 114615003802 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors...; Region: LuxR_C_like; cd06170 114615003803 DNA binding residues [nucleotide binding] 114615003804 dimerization interface [polypeptide binding]; other site 114615003805 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 114615003806 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156 114615003807 active site 114615003808 phosphorylation site [posttranslational modification] 114615003809 intermolecular recognition site; other site 114615003810 dimerization interface [polypeptide binding]; other site 114615003811 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors...; Region: LuxR_C_like; cd06170 114615003812 DNA binding residues [nucleotide binding] 114615003813 dimerization interface [polypeptide binding]; other site 114615003814 quinoprotein dehydrogenase-associated probable ABC transporter substrate-binding protein; Region: ABC_peri_MoxJ_2; TIGR03871 114615003815 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and...; Region: PBPb; cd00134 114615003816 substrate binding pocket [chemical binding]; other site 114615003817 membrane-bound complex binding site; other site 114615003818 hinge residues; other site 114615003819 Cytochrome c; Region: Cytochrom_C; cl11414 114615003820 PQQ-dependent dehydrogenase, methanol/ethanol family; Region: PQQ_enz_alc_DH; TIGR03075 114615003821 Dehydrogenases with pyrrolo-quinoline quinone (PQQ) as cofactor, like ethanol, methanol, and membrane bound glucose dehydrogenases. The alignment model contains an 8-bladed beta-propeller; Region: PQQ_DH; cl11493 114615003822 Trp docking motif; other site 114615003823 'Velcro' closure; other site 114615003824 active site 114615003825 Tfp pilus assembly protein PilF [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilF; COG3063 114615003826 DNA Polymerase IV/Kappa; Region: PolY_Pol_IV_kappa; cd03586 114615003827 active site 114615003828 DNA polymerase IV; Validated; Region: PRK02406 114615003829 DNA binding site [nucleotide binding] 114615003830 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 114615003831 potassium uptake protein; Region: kup; TIGR00794 114615003832 K+ potassium transporter; Region: K_trans; cl01227 114615003833 chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168 114615003834 Protein of unknown function (DUF1134); Region: DUF1134; cl02235 114615003835 CysQ, a 3'-Phosphoadenosine-5'-phosphosulfate (PAPS) 3'-phosphatase, is a bacterial member of the inositol monophosphatase family. It has been proposed that CysQ helps control intracellular levels of PAPS, which is an intermediate in cysteine...; Region: CysQ; cd01638 114615003836 active site 114615003837 Uncharacterized protein conserved in bacteria (DUF2328); Region: DUF2328; pfam10090 114615003838 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 114615003839 putative binding surface; other site 114615003840 active site 114615003841 Signal transducing histidine kinase, homodimeric domain; Region: H-kinase_dim; pfam02895 114615003842 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 114615003843 ATP binding site [chemical binding]; other site 114615003844 Mg2+ binding site [ion binding]; other site 114615003845 G-X-G motif; other site 114615003846 CheA regulatory domain; CheA is a histidine protein kinase present in bacteria and archea. Activated by the chemotaxis receptor a histidine phosphoryl group from CheA is passed directly to an aspartate in the response regulator CheY. This signalling...; Region: CheA_reg; cd00731 114615003847 CheW-like domain. CheW proteins are part of the chemotaxis signalling mechanism in bacteria. CheW interacts with the methyl accepting chemotaxis proteins (MCPs) and relays signals to CheY, which affects flageller rotation. This family includes CheW and...; Region: CheW_like; cl00256 114615003848 Response regulator receiver domain; Region: Response_reg; pfam00072 114615003849 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156 114615003850 active site 114615003851 phosphorylation site [posttranslational modification] 114615003852 intermolecular recognition site; other site 114615003853 dimerization interface [polypeptide binding]; other site 114615003854 CheW-like domain. CheW proteins are part of the chemotaxis signalling mechanism in bacteria. CheW interacts with the methyl accepting chemotaxis proteins (MCPs) and relays signals to CheY, which affects flageller rotation. This family includes CheW and...; Region: CheW_like; cl00256 114615003855 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156 114615003856 Response regulator receiver domain; Region: Response_reg; pfam00072 114615003857 active site 114615003858 phosphorylation site [posttranslational modification] 114615003859 intermolecular recognition site; other site 114615003860 dimerization interface [polypeptide binding]; other site 114615003861 chemotaxis-specific methylesterase; Provisional; Region: PRK00742 114615003862 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156 114615003863 active site 114615003864 phosphorylation site [posttranslational modification] 114615003865 intermolecular recognition site; other site 114615003866 dimerization interface [polypeptide binding]; other site 114615003867 CheB methylesterase; Region: CheB_methylest; pfam01339 114615003868 CheR methyltransferase, all-alpha domain; Region: CheR_N; pfam03705 114615003869 Methyltransferase, chemotaxis proteins; Region: MeTrc; smart00138 114615003870 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cl12011 114615003871 circadian clock protein KaiC; Reviewed; Region: PRK09302 114615003872 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 114615003873 Walker A motif; other site 114615003874 ATP binding site [chemical binding]; other site 114615003875 Walker B motif; other site 114615003876 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 114615003877 Walker A motif; other site 114615003878 ATP binding site [chemical binding]; other site 114615003879 Walker B motif; other site 114615003880 KaiB-like family; composed of the circadian clock proteins, KaiB and the N-terminal KaiB-like sensory domain of SasA. KaiB is an essential protein in maintaining circadian rhythm. It was originally discovered from the cyanobacterium Synechococcus as...; Region: KaiB_like; cd02978 114615003881 tetramer interface [polypeptide binding]; other site 114615003882 dimer interface [polypeptide binding]; other site 114615003883 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459 114615003884 hypothetical protein; Provisional; Region: PRK13560 114615003885 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920 114615003886 Histidine kinase; Region: HisKA_2; cl06527 114615003887 Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms]; Region: LytT; COG3279 114615003888 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cl09944 114615003889 Glutathionylspermidine synthase; Region: GSP_synth; cl00503 114615003890 Predicted membrane protein [Function unknown]; Region: COG3766 114615003891 Transcriptional regulators [Transcription]; Region: GntR; COG1802 114615003892 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 114615003893 DNA-binding site [nucleotide binding]; DNA binding site 114615003894 FCD domain; Region: FCD; cl11656 114615003895 ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components [Inorganic ion transport and metabolism]; Region: TauA; COG0715 114615003896 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 114615003897 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261 114615003898 dimer interface [polypeptide binding]; other site 114615003899 conserved gate region; other site 114615003900 putative PBP binding loops; other site 114615003901 ABC-ATPase subunit interface; other site 114615003902 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 114615003903 NrtD and SsuB are the ATP-binding subunits of the bacterial ABC-type nitrate and sulfonate transport systems, respectively. ABC transporters are a large family of proteins involved in the transport of a wide variety of different compounds, like sugars...; Region: ABC_NrtD_SsuB_transporters; cd03293 114615003904 Walker A/P-loop; other site 114615003905 ATP binding site [chemical binding]; other site 114615003906 Q-loop/lid; other site 114615003907 ABC transporter signature motif; other site 114615003908 Walker B; other site 114615003909 D-loop; other site 114615003910 H-loop/switch region; other site 114615003911 Asp/Glu/Hydantoin racemase; Region: Asp_Glu_race; cl00518 114615003912 dihydropyrimidinase; Provisional; Region: PRK13404 114615003913 D-hydantoinases (D-HYD) also called dihydropyrimidases (DHPase) and related proteins; DHPases are a family of enzymes that catalyze the reversible hydrolytic ring opening of the amide bond in five- or six-membered cyclic diamides, like...; Region: D-HYD; cd01314 114615003914 tetramer interface [polypeptide binding]; other site 114615003915 active site 114615003916 Catalytic domain of phospholipase D superfamily proteins; Region: PLDc_SF; cl15239 114615003917 putative active site [active] 114615003918 catalytic site [active] 114615003919 Putative catalytic domain, repeat 2, of uncharacterized hypothetical proteins similar to Nuc, an endonuclease from Salmonella typhimurium; Region: PLDc_Nuc_like_unchar1_2; cd09173 114615003920 putative active site [active] 114615003921 catalytic site [active] 114615003922 OstA-like protein; Region: OstA; cl00844 114615003923 Cytochrome c; Region: Cytochrom_C; cl11414 114615003924 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 114615003925 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156 114615003926 active site 114615003927 phosphorylation site [posttranslational modification] 114615003928 intermolecular recognition site; other site 114615003929 dimerization interface [polypeptide binding]; other site 114615003930 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase...; Region: trans_reg_C; cd00383 114615003931 DNA binding site [nucleotide binding] 114615003932 flagellum-specific ATP synthase; Validated; Region: fliI; PRK08927 114615003933 Flagellum-specific ATPase/type III secretory pathway virulence-related protein. This group of ATPases are responsible for the export of flagellum and virulence-related proteins. The bacterial flagellar motor is similar to the F0F1-ATPase, in that they...; Region: ATPase_flagellum-secretory_path_III; cd01136 114615003934 Walker A motif/ATP binding site; other site 114615003935 Walker B motif; other site 114615003936 flagellar export protein FliJ; Region: flagell_FliJ; TIGR02473 114615003937 RNA polymerase sigma factor; Provisional; Region: PRK12514 114615003938 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 114615003939 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl15258 114615003940 Anti-sigma-K factor rskA; Region: RskA; cl02208 114615003941 Anti-sigma-K factor rskA; Region: RskA; cl02208 114615003942 Flagellar biosynthesis pathway, component FlhA [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FlhA; cl07980 114615003943 flagellar biosynthesis protein FlhA; Validated; Region: flhA; PRK06012 114615003944 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 114615003945 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 114615003946 substrate binding pocket [chemical binding]; other site 114615003947 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 114615003948 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl14614 114615003949 type III secretion low calcium response chaperone LcrH/SycD; Region: LcrH_SycD; TIGR02552 114615003950 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi...; Region: TPR; cd00189 114615003951 binding surface 114615003952 TPR motif; other site 114615003953 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi...; Region: TPR; cd00189 114615003954 binding surface 114615003955 TPR motif; other site 114615003956 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi...; Region: TPR; cd00189 114615003957 binding surface 114615003958 TPR motif; other site 114615003959 Predicted O-linked N-acetylglucosamine transferase, SPINDLY family [Posttranslational modification, protein turnover, chaperones]; Region: Spy; COG3914 114615003960 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 114615003961 Coenzyme A binding pocket [chemical binding]; other site 114615003962 shikimate kinase; Reviewed; Region: aroK; PRK00131 114615003963 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 114615003964 Active site [active] 114615003965 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 114615003966 Taxis toward Aspartate and Related amino acids and Homologs (TarH). The Tar chemoreceptor of Escherichia coli mediates attractant responses to aspartate, maltose, and phenol, repellent responses to Ni2+ and Co2+, and thermoresponses. These...; Region: TarH; cl00144 114615003967 Copper binding periplasmic protein CusF; Region: CusF_Ec; cl02363 114615003968 Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; cl11412 114615003969 Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; cl11412 114615003970 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 114615003971 Major Facilitator Superfamily; Region: MFS_1; pfam07690 114615003972 putative substrate translocation pore; other site 114615003973 Tripartite tricarboxylate transporter family receptor; Region: TctC; cl15260 114615003974 kynureninase; Region: kynureninase; TIGR01814 114615003975 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 114615003976 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 114615003977 catalytic residue [active] 114615003978 Tryptophan 2,3-dioxygenase; Region: Trp_dioxygenase; cl03994 114615003979 Esterase/lipase [Lipid metabolism]; Region: Aes; COG0657 114615003980 GGCT-like domains, also called AIG2-like family. Gamma-glutamyl cyclotransferase (GGCT) catalyzes the formation of pyroglutamic acid (5-oxoproline) from dipeptides containing gamma-glutamyl, and is a dimeric protein. In Homo sapiens, the protein is...; Region: GGCT_like; cl11426 114615003981 haloacid dehalogenase-like hydrolase; Region: Hydrolase; pfam00702 114615003982 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others...; Region: HAD_like; cd01427 114615003983 motif I; other site 114615003984 motif II; other site 114615003985 Transcriptional regulator [Transcription]; Region: LysR; COG0583 114615003986 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 114615003987 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 114615003988 dimerization interface [polypeptide binding]; other site 114615003989 Gamma-glutamyltransferase [Amino acid transport and metabolism]; Region: Ggt; cl08040 114615003990 Gamma-glutamyltranspeptidase; Region: G_glu_transpept; pfam01019 114615003991 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 114615003992 homotrimer interaction site [polypeptide binding]; other site 114615003993 putative active site [active] 114615003994 DNA-binding transcriptional activator FeaR; Provisional; Region: PRK09685 114615003995 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 114615003996 Acetamidase/Formamidase family; Region: FmdA_AmdA; cl01023 114615003997 Acetamidase/Formamidase family; Region: FmdA_AmdA; cl01023 114615003998 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 114615003999 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261 114615004000 dimer interface [polypeptide binding]; other site 114615004001 conserved gate region; other site 114615004002 putative PBP binding loops; other site 114615004003 ABC-ATPase subunit interface; other site 114615004004 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 114615004005 HisP and GlnQ are the ATP-binding components of the bacterial periplasmic histidine and glutamine permeases, repectively. Histidine permease is a multisubunit complex containing the HisQ and HisM integral membrane subunits and two copies of HisP; Region: ABC_HisP_GlnQ_permeases; cd03262 114615004006 Walker A/P-loop; other site 114615004007 ATP binding site [chemical binding]; other site 114615004008 Q-loop/lid; other site 114615004009 ABC transporter signature motif; other site 114615004010 Walker B; other site 114615004011 D-loop; other site 114615004012 H-loop/switch region; other site 114615004013 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and...; Region: PBPb; cd00134 114615004014 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 114615004015 substrate binding pocket [chemical binding]; other site 114615004016 membrane-bound complex binding site; other site 114615004017 hinge residues; other site 114615004018 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 114615004019 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261 114615004020 dimer interface [polypeptide binding]; other site 114615004021 conserved gate region; other site 114615004022 putative PBP binding loops; other site 114615004023 ABC-ATPase subunit interface; other site 114615004024 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 114615004025 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 114615004026 Walker A/P-loop; other site 114615004027 ATP binding site [chemical binding]; other site 114615004028 Q-loop/lid; other site 114615004029 ABC transporter signature motif; other site 114615004030 Walker B; other site 114615004031 D-loop; other site 114615004032 H-loop/switch region; other site 114615004033 TOBE domain; Region: TOBE_2; cl01440 114615004034 Spermidine/putrescine-binding periplasmic protein [Amino acid transport and metabolism]; Region: PotD; COG0687 114615004035 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 114615004036 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261 114615004037 dimer interface [polypeptide binding]; other site 114615004038 conserved gate region; other site 114615004039 putative PBP binding loops; other site 114615004040 ABC-ATPase subunit interface; other site 114615004041 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have...; Region: metallo-dependent_hydrolases; cl00281 114615004042 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have...; Region: metallo-dependent_hydrolases; cl00281 114615004043 active site 114615004044 amidohydrolase; Provisional; Region: PRK12393 114615004045 Ras-like GTPase superfamily. The Ras-like superfamily of small GTPases consists of several families with an extremely high degree of structural and functional similarity. The Ras superfamily is divided into at least four families in eukaryotes: the Ras...; Region: Ras_like_GTPase; cl10444 114615004046 Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; cl08458 114615004047 Transcriptional regulator [Transcription]; Region: IclR; COG1414 114615004048 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 114615004049 Bacterial transcriptional regulator; Region: IclR; pfam01614 114615004050 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 114615004051 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 114615004052 Walker A/P-loop; other site 114615004053 ATP binding site [chemical binding]; other site 114615004054 Q-loop/lid; other site 114615004055 ABC transporter signature motif; other site 114615004056 Walker B; other site 114615004057 D-loop; other site 114615004058 H-loop/switch region; other site 114615004059 TOBE domain; Region: TOBE_2; cl01440 114615004060 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261 114615004061 dimer interface [polypeptide binding]; other site 114615004062 conserved gate region; other site 114615004063 putative PBP binding loops; other site 114615004064 ABC-ATPase subunit interface; other site 114615004065 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 114615004066 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261 114615004067 dimer interface [polypeptide binding]; other site 114615004068 ABC-ATPase subunit interface; other site 114615004069 putative PBP binding loops; other site 114615004070 NADH dehydrogenase subunit G; Validated; Region: PRK08493 114615004071 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_2; pfam07992 114615004072 sn-glycerol-3-phosphate dehydrogenase subunit A; Provisional; Region: glpA; PRK11101 114615004073 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 114615004074 Malate:quinone oxidoreductase (Mqo); Region: Mqo; cl14881 114615004075 Spermidine/putrescine-binding periplasmic protein [Amino acid transport and metabolism]; Region: PotD; COG0687 114615004076 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 114615004077 Pyridoxine 5'-phosphate (PNP) oxidase-like proteins; Region: PNPOx_like; cl00381 114615004078 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 114615004079 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 114615004080 DNA-binding site [nucleotide binding]; DNA binding site 114615004081 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 114615004082 pyridoxal 5'-phosphate binding site [chemical binding]; other site 114615004083 homodimer interface [polypeptide binding]; other site 114615004084 catalytic residue [active] 114615004085 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 114615004086 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 114615004087 Peptidase M4 family containing mostly uncharacterized proteins; Region: M4_uncharacterized; cd09598 114615004088 Zn binding site [ion binding]; other site 114615004089 Patatins and Phospholipases; Region: Patatin_and_cPLA2; cl11396 114615004090 active site 114615004091 nucleophile elbow; other site 114615004092 Class II Aldolase and Adducin head (N-terminal) domain. Aldolases are ubiquitous enzymes catalyzing central steps of carbohydrate metabolism. Based on enzymatic mechanisms, this superfamily has been divided into two distinct classes (Class I and II)...; Region: Aldolase_II; cl00214 114615004093 active site 114615004094 intersubunit interface [polypeptide binding]; other site 114615004095 Zn2+ binding site [ion binding]; other site 114615004096 galactarate dehydratase; Region: galactar-dH20; TIGR03248 114615004097 SAF domain; Region: SAF; cl00555 114615004098 SAF domain; Region: SAF; cl00555 114615004099 Bacillus subtilis NADP+-dependent alpha-ketoglutaric semialdehyde dehydrogenase ycbD-like; Region: ALDH_KGSADH-YcbD; cd07097 114615004100 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 114615004101 NAD(P) binding site [chemical binding]; other site 114615004102 catalytic residues [active] 114615004103 glucarate dehydratase; Region: glucar-dehydr; TIGR03247 114615004104 D-Glucarate dehydratase (GlucD) catalyzes the dehydration of both D-glucarate and L-idarate to form 5-keto-4-deoxy-D-glucarate (5-KDG) , the initial reaction of the catabolic pathway for (D)-glucarate. GlucD belongs to the enolase superfamily of...; Region: D-glucarate_dehydratase; cd03323 114615004105 active site 114615004106 tetramer interface [polypeptide binding]; other site 114615004107 Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329 114615004108 5-dehydro-4-deoxyglucarate dehydratase, also called 5-keto-4-deoxy-glucarate dehydratase (KDGDH); Region: KDGDH; cd00951 114615004109 putative active site [active] 114615004110 catalytic residue [active] 114615004111 DNA-binding transcriptional regulator HcaR; Provisional; Region: PRK09906 114615004112 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 114615004113 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator similar to regulators involved in the catabolism of aromatic compounds, contains type 2 periplasmic binding fold; Region: PBP2_LTTR_aromatics_like_1; cd08447 114615004114 putative dimerization interface [polypeptide binding]; other site 114615004115 putative substrate binding pocket [chemical binding]; other site 114615004116 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 114615004117 D-galactonate transporter; Region: 2A0114; TIGR00893 114615004118 putative substrate translocation pore; other site 114615004119 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 114615004120 Deacetylases, including yeast histone deacetylase and acetoin utilization protein [Chromatin structure and dynamics / Secondary metabolites biosynthesis, transport, and catabolism]; Region: AcuC; COG0123 114615004121 Histone deacetylase domain; Region: Hist_deacetyl; cl02986 114615004122 hybrid sensory histidine kinase TorS; Provisional; Region: PRK11466 114615004123 Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices connected by an extended linker. The...; Region: HAMP; cl01054 114615004124 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 114615004125 Taxis toward Aspartate and Related amino acids and Homologs (TarH). The Tar chemoreceptor of Escherichia coli mediates attractant responses to aspartate, maltose, and phenol, repellent responses to Ni2+ and Co2+, and thermoresponses. These...; Region: TarH; cl00144 114615004126 phosphoenolpyruvate synthase; Validated; Region: PRK06464 114615004127 Pyruvate phosphate dikinase, PEP/pyruvate binding domain; Region: PPDK_N; pfam01326 114615004128 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; cl01586 114615004129 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl09155 114615004130 ABC transporter transmembrane region; Region: ABC_membrane; cl00549 114615004131 Fructose-1-phosphate kinase and related fructose-6-phosphate kinase (PfkB) [Carbohydrate transport and metabolism]; Region: FruK; COG1105 114615004132 1-phosphofructokinase (FruK), minor 6-phosphofructokinase (pfkB) and related sugar kinases. FruK plays an important role in the predominant pathway for fructose utilisation.This group also contains tagatose-6-phophate kinase, an enzyme of the tagatose...; Region: FruK_PfkB_like; cd01164 114615004133 putative substrate binding site [chemical binding]; other site 114615004134 putative ATP binding site [chemical binding]; other site 114615004135 FGGY family of carbohydrate kinases, N-terminal domain; Region: FGGY_N; cl09121 114615004136 Beta-glucosidase/6-phospho-beta-glucosidase/beta- galactosidase [Carbohydrate transport and metabolism]; Region: BglB; cl01046 114615004137 Glycosyl hydrolase family 1; Region: Glyco_hydro_1; pfam00232 114615004138 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 114615004139 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261 114615004140 dimer interface [polypeptide binding]; other site 114615004141 ABC-ATPase subunit interface; other site 114615004142 putative PBP binding loops; other site 114615004143 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261 114615004144 dimer interface [polypeptide binding]; other site 114615004145 conserved gate region; other site 114615004146 putative PBP binding loops; other site 114615004147 ABC-ATPase subunit interface; other site 114615004148 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 114615004149 The ABC transporter subfamily specific for the transport of dipeptides, oligopeptides (OppD), and nickel (NikDE). The NikABCDE system of E. coli belongs to this family and is composed of the periplasmic binding protein NikA, two integral membrane...; Region: ABC_NikE_OppD_transporters; cd03257 114615004150 Walker A/P-loop; other site 114615004151 ATP binding site [chemical binding]; other site 114615004152 Q-loop/lid; other site 114615004153 ABC transporter signature motif; other site 114615004154 Walker B; other site 114615004155 D-loop; other site 114615004156 H-loop/switch region; other site 114615004157 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 114615004158 dipeptide transporter ATP-binding subunit; Provisional; Region: dppF; PRK11308 114615004159 The ABC transporter subfamily specific for the transport of dipeptides, oligopeptides (OppD), and nickel (NikDE). The NikABCDE system of E. coli belongs to this family and is composed of the periplasmic binding protein NikA, two integral membrane...; Region: ABC_NikE_OppD_transporters; cd03257 114615004160 Walker A/P-loop; other site 114615004161 ATP binding site [chemical binding]; other site 114615004162 Q-loop/lid; other site 114615004163 ABC transporter signature motif; other site 114615004164 Walker B; other site 114615004165 D-loop; other site 114615004166 H-loop/switch region; other site 114615004167 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 114615004168 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_6; cd08494 114615004169 Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496 114615004170 Thioredoxin reductase [Posttranslational modification, protein turnover, chaperones]; Region: TrxB; COG0492 114615004171 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 114615004172 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 114615004173 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261 114615004174 dimer interface [polypeptide binding]; other site 114615004175 conserved gate region; other site 114615004176 ABC-ATPase subunit interface; other site 114615004177 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 114615004178 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261 114615004179 dimer interface [polypeptide binding]; other site 114615004180 conserved gate region; other site 114615004181 putative PBP binding loops; other site 114615004182 ABC-ATPase subunit interface; other site 114615004183 dipeptide transporter ATP-binding subunit; Provisional; Region: dppF; PRK11308 114615004184 The ABC transporter subfamily specific for the transport of dipeptides, oligopeptides (OppD), and nickel (NikDE). The NikABCDE system of E. coli belongs to this family and is composed of the periplasmic binding protein NikA, two integral membrane...; Region: ABC_NikE_OppD_transporters; cd03257 114615004185 Walker A/P-loop; other site 114615004186 ATP binding site [chemical binding]; other site 114615004187 Q-loop/lid; other site 114615004188 ABC transporter signature motif; other site 114615004189 Walker B; other site 114615004190 D-loop; other site 114615004191 H-loop/switch region; other site 114615004192 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 114615004193 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 114615004194 The ABC transporter subfamily specific for the transport of dipeptides, oligopeptides (OppD), and nickel (NikDE). The NikABCDE system of E. coli belongs to this family and is composed of the periplasmic binding protein NikA, two integral membrane...; Region: ABC_NikE_OppD_transporters; cd03257 114615004195 Walker A/P-loop; other site 114615004196 ATP binding site [chemical binding]; other site 114615004197 Q-loop/lid; other site 114615004198 ABC transporter signature motif; other site 114615004199 Walker B; other site 114615004200 D-loop; other site 114615004201 H-loop/switch region; other site 114615004202 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 114615004203 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_10; cd08515 114615004204 Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496 114615004205 Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261 114615004206 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of D-arabino-6-...; Region: AP2Ec; cl12060 114615004207 Metal-binding active site; metal-binding site 114615004208 Glutamine cyclotransferase [Posttranslational modification, protein turnover, chaperones]; Region: COG3823 114615004209 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 114615004210 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 114615004211 NrtD and SsuB are the ATP-binding subunits of the bacterial ABC-type nitrate and sulfonate transport systems, respectively. ABC transporters are a large family of proteins involved in the transport of a wide variety of different compounds, like sugars...; Region: ABC_NrtD_SsuB_transporters; cd03293 114615004212 Walker A/P-loop; other site 114615004213 ATP binding site [chemical binding]; other site 114615004214 Q-loop/lid; other site 114615004215 ABC transporter signature motif; other site 114615004216 Walker B; other site 114615004217 D-loop; other site 114615004218 H-loop/switch region; other site 114615004219 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261 114615004220 dimer interface [polypeptide binding]; other site 114615004221 conserved gate region; other site 114615004222 putative PBP binding loops; other site 114615004223 ABC-ATPase subunit interface; other site 114615004224 ABC transporter, substrate-binding protein, aliphatic sulfonates family; Region: SsuA_fam; TIGR01728 114615004225 Tripartite tricarboxylate transporter family receptor; Region: TctC; cl15260 114615004226 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 114615004227 DNA-binding site [nucleotide binding]; DNA binding site 114615004228 histidine utilization repressor, proteobacterial; Region: his_ut_repres; TIGR02018 114615004229 UTRA domain; Region: UTRA; cl01230 114615004230 N-formimino-L-glutamate deiminase; Validated; Region: PRK09229 114615004231 Metallo-dependent hydrolases, subgroup D is part of the superfamily of metallo-dependent hydrolases, a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the...; Region: Met_dep_hydrolase_E; cd01313 114615004232 active site 114615004233 Imidazolonepropionase and related amidohydrolases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: HutI; COG1228 114615004234 Imidazolonepropionase/imidazolone-5-propionate hydrolase (Imidazolone-5PH) catalyzes the third step in the histidine degradation pathway, the hydrolysis of (S)-3-(5-oxo-4,5-dihydro-3H-imidazol-4-yl)propanoate to N-formimidoyl-L-glutamate. In bacteria...; Region: Imidazolone-5PH; cd01296 114615004235 active site 114615004236 Phenylalanine ammonia-lyase (PAL) and histidine ammonia-lyase (HAL); Region: PAL-HAL; cd00332 114615004237 active sites [active] 114615004238 tetramer interface [polypeptide binding]; other site 114615004239 urocanate hydratase; Provisional; Region: PRK05414 114615004240 urocanate hydratase; Region: hutU; TIGR01228 114615004241 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 114615004242 magnesium chelatase subunit I; Provisional; Region: bchI; PRK13407 114615004243 magnesium chelatase subunit D; Provisional; Region: bchD; PRK13406 114615004244 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 114615004245 Magnesium chelatase: Mg-chelatase catalyses the insertion of Mg into protoporphyrin IX (Proto). In chlorophyll biosynthesis, insertion of Mg2+ into protoporphyrin IX is catalysed by magnesium chelatase in an ATP-dependent reaction. Magnesium chelatase...; Region: vWA_Magnesium_chelatase; cd01451 114615004246 metal ion-dependent adhesion site (MIDAS); other site 114615004247 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 114615004248 putative magnesium chelatase accessory protein; Region: bchO_mg_che_rel; TIGR03056 114615004249 Phytoene dehydrogenase and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG1233 114615004250 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 114615004251 Trans-Isoprenyl Diphosphate Synthases, head-to-head; Region: Trans_IPPS_HH; cd00683 114615004252 active site lid residues [active] 114615004253 substrate binding pocket [chemical binding]; other site 114615004254 catalytic residues [active] 114615004255 substrate-Mg2+ binding site; other site 114615004256 aspartate-rich region 1; other site 114615004257 aspartate-rich region 2; other site 114615004258 Hydroxyneurosporene synthase (CrtC); Region: CrtC; cl12101 114615004259 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 114615004260 Phytoene dehydrogenase and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG1233 114615004261 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 114615004262 substrate binding pocket [chemical binding]; other site 114615004263 chain length determination region; other site 114615004264 substrate-Mg2+ binding site; other site 114615004265 catalytic residues [active] 114615004266 aspartate-rich region 1; other site 114615004267 active site lid residues [active] 114615004268 aspartate-rich region 2; other site 114615004269 O-methyltransferase; Region: Methyltransf_2; pfam00891 114615004270 2-desacetyl-2-hydroxyethyl bacteriochlorophyllide A dehydrogenase; Region: bchC; TIGR01202 114615004271 2-desacetyl-2-hydroxyethyl bacteriochlorophyllide and other MDR family members; Region: 2-desacetyl-2-hydroxyethyl_bacteriochlorophyllide_; cd08255 114615004272 putative NAD(P) binding site [chemical binding]; other site 114615004273 Ras-like GTPase superfamily. The Ras-like superfamily of small GTPases consists of several families with an extremely high degree of structural and functional similarity. The Ras superfamily is divided into at least four families in eukaryotes: the Ras...; Region: Ras_like_GTPase; cl10444 114615004274 chlorophyllide reductase iron protein subunit X; Region: BchX; TIGR02016 114615004275 Chlide_reductase_Y : Y subunit of chlorophyllide (chlide) reductase (BchY). Chlide reductase participates in photosynthetic pigment synthesis playing a role in the conversion of chlorophylls(Chl) into bacteriochlorophylls (BChl). Chlide reductase...; Region: Chlide_reductase_Y; cd01980 114615004276 chlorophyllide reductase subunit Y; Region: BchY; TIGR02015 114615004277 The nitrogenase enzyme system catalyzes the ATP-dependent reduction of dinitrogen to ammonia. This group contains both alpha and beta subunits of component 1 of the three known genetically distinct types of nitrogenase systems: a molybdenum-dependent...; Region: Oxidoreductase_nitrogenase; cl02775 114615004278 chlorophyllide reductase subunit Z; Region: BchZ; TIGR02014 114615004279 Proto-chlorophyllide reductase 57 kD subunit; Region: PCP_red; pfam08369 114615004280 Antenna complex alpha/beta subunit; Region: LHC; pfam00556 114615004281 Subunit L of bacterial photosynthetic reaction center; Region: Photo-RC_L; cd09290 114615004282 subunit M interface; other site 114615004283 subunit H interface; other site 114615004284 quinone binding site; other site 114615004285 bacteriopheophytin binding site; other site 114615004286 bacteriochlorophyll binding site; other site 114615004287 cytochrome C subunit interface; other site 114615004288 Fe binding site [ion binding]; other site 114615004289 Subunit M of bacterial photosynthetic reaction center; Region: Photo-RC_M; cd09291 114615004290 subunit H interface; other site 114615004291 subunit L interface; other site 114615004292 bacteriopheophytin binding site; other site 114615004293 carotenoid binding site; other site 114615004294 bacteriochlorophyll binding site; other site 114615004295 cytochrome C interface; other site 114615004296 quinone binding site; other site 114615004297 Fe binding site [ion binding]; other site 114615004298 Heme oxygenase catalyzes the rate limiting step in the degradation of heme to bilirubin, it is essential for recycling of iron from heme. Heme is used as a substrate and cofactor for its own degradation to biliverdin, iron, and carbon monoxide. This...; Region: HemeO; cd00232 114615004299 heme binding pocket [chemical binding]; other site 114615004300 heme ligand [chemical binding]; other site 114615004301 Transposase domain (DUF772); Region: DUF772; cl12084 114615004302 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 114615004303 PAS fold; Region: PAS_2; pfam08446 114615004304 GAF domain; Region: GAF; cl00853 114615004305 Phytochrome region; Region: PHY; pfam00360 114615004306 transcriptional regulator PpsR; Region: PpsR-CrtJ; TIGR02040 114615004307 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459 114615004308 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459 114615004309 Bacterial regulatory protein, Fis family; Region: HTH_8; cl01091 114615004310 Cytochrome c; Region: Cytochrom_C; cl11414 114615004311 geranylgeranyl reductase; Region: BchP-ChlP; TIGR02023 114615004312 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 114615004313 PUCC protein; Region: PUCC; pfam03209 114615004314 UbiA prenyltransferase family; Region: UbiA; cl00337 114615004315 transcriptional regulator PpsR; Region: PpsR-CrtJ; TIGR02040 114615004316 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459 114615004317 Bacterial regulatory protein, Fis family; Region: HTH_8; cl01091 114615004318 B12 binding domain (B12-BD). Most of the members bind different cobalamid derivates, like B12 (adenosylcobamide) or methylcobalamin or methyl-Co(III) 5-hydroxybenzimidazolylcobamide. This domain is found in several enzymes, such as glutamate mutase...; Region: B12-binding_like; cl00293 114615004319 2-vinyl bacteriochlorophyllide hydratase (BCHF); Region: BCHF; cl06353 114615004320 The nitrogenase enzyme system catalyzes the ATP-dependent reduction of dinitrogen to ammonia. This group contains both alpha and beta subunits of component 1 of the three known genetically distinct types of nitrogenase systems: a molybdenum-dependent...; Region: Oxidoreductase_nitrogenase; cl02775 114615004321 light-independent protochlorophyllide reductase, N subunit; Region: DPOR_bchN; TIGR01279 114615004322 light-independent protochlorophyllide reductase subunit B; Provisional; Region: PRK02910 114615004323 Pchlide_reductase_B: B protein of the NB protein complex of Protochlorophyllide (Pchlide)_reductase. Pchlide reductase catalyzes the reductive formation of chlorophyllide (chlide) from protochlorophyllide (pchlide) during biosynthesis of chlorophylls...; Region: Pchlide_reductase_B; cd01981 114615004324 Proto-chlorophyllide reductase 57 kD subunit; Region: PCP_red; pfam08369 114615004325 magnesium chelatase subunit H; Provisional; Region: bchH; PRK13405 114615004326 Domain of unknown function (DUF3479); Region: DUF3479; pfam11965 114615004327 protochlorophyllide reductase iron-sulfur ATP-binding protein; Provisional; Region: chlL; PRK13185 114615004328 This family of proteins contains bchL and chlL. Protochlorophyllide reductase catalyzes the reductive formation of chlorophyllide from protochlorophyllide during biosynthesis of chlorophylls and bacteriochlorophylls. Three genes, bchL, bchN and bchB...; Region: Bchl_like; cd02032 114615004329 P-loop; other site 114615004330 Mg-protoporphyrin IX methyl transferase; Validated; Region: PRK07580 114615004331 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cl12011 114615004332 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cl12011 114615004333 PUCC protein; Region: PUCC; pfam03209 114615004334 photosynthetic reaction center, subunit H, bacterial; Region: puhA; TIGR01150 114615004335 Photosynthetic reaction center (RC) complex, subunit H; RC is an integral membrane protein-pigment complex which catalyzes light-induced reduction of ubiquinone to ubiquinol, generating a transmembrane electrochemical gradient of protons used to...; Region: PRCH; cl09959 114615004336 subunit M interaction residues [polypeptide binding]; other site 114615004337 subunit L interaction residues [polypeptide binding]; other site 114615004338 putative proton transfer pathway, P1; other site 114615004339 putative proton transfer pathway, P2; other site 114615004340 putative photosynthetic complex assembly protein; Region: photo_alph_chp1; TIGR03054 114615004341 Aerobic Cyclase System Fe-containing subunit (ACSF), ferritin-like diiron-binding domain; Region: ACSF; cd01047 114615004342 diiron binding motif [ion binding]; other site 114615004343 Protein of unknown function (DUF3623); Region: DUF3623; cl11843 114615004344 7-keto-8-aminopelargonate synthetase and related enzymes [Coenzyme metabolism]; Region: BioF; COG0156 114615004345 KBL_like; this family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to serine palmitoyltransferase (SPT), 5-aminolevulinate synthase (ALAS), 8-amino-7-...; Region: KBL_like; cd06454 114615004346 substrate-cofactor binding pocket; other site 114615004347 pyridoxal 5'-phosphate binding site [chemical binding]; other site 114615004348 catalytic residue [active] 114615004349 magnesium-protoporphyrin IX monomethyl ester anaerobic oxidative cyclase; Region: BchE; TIGR02026 114615004350 B12 binding domain_like associated with radical SAM domain. This domain shows similarity with B12 (adenosylcobamide) binding domains found in several enzymes, such as glutamate mutase, methionine synthase and methylmalonyl-CoA mutase, but it lacks the...; Region: radical_SAM_B12_BD; cd02068 114615004351 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster...; Region: Radical_SAM; cl15259 114615004352 Heme NO binding; Region: HNOB; cl15268 114615004353 Transcriptional regulator [Transcription]; Region: LysR; COG0583 114615004354 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 114615004355 The C-terminal substrate binding of LysR-type transcriptional regulator (CbbR) of RubisCO operon, which is involved in the carbon dioxide fixation, contains the type 2 periplasmic binding fold; Region: PBP2_CbbR_RubisCO_like; cd08419 114615004356 putative dimerization interface [polypeptide binding]; other site 114615004357 Fructose-1,6-bisphosphatase, an enzyme that catalyzes the hydrolysis of fructose-1,6-biphosphate into fructose-6-phosphate and is critical in gluconeogenesis pathway. The alignment model also includes chloroplastic FBPases and sedoheptulose-1,7-...; Region: FBPase; cd00354 114615004358 AMP binding site [chemical binding]; other site 114615004359 metal binding site [ion binding]; metal-binding site 114615004360 active site 114615004361 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 114615004362 transketolase; Reviewed; Region: PRK05899 114615004363 Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012 114615004364 TPP-binding site [chemical binding]; other site 114615004365 dimer interface [polypeptide binding]; other site 114615004366 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 114615004367 PYR/PP interface [polypeptide binding]; other site 114615004368 dimer interface [polypeptide binding]; other site 114615004369 TPP binding site [chemical binding]; other site 114615004370 hypothetical protein; Provisional; Region: PRK08185 114615004371 Tagatose-1,6-bisphosphate (TBP) aldolase and related Type B Class II aldolases. TBP aldolase is a tetrameric class II aldolase that catalyzes the reversible condensation of dihydroxyacetone phosphate with glyceraldehyde 3-phsophate to produce tagatose...; Region: TBP_aldolase_IIB; cd00947 114615004372 intersubunit interface [polypeptide binding]; other site 114615004373 active site 114615004374 zinc binding site [ion binding]; other site 114615004375 Na+ binding site [ion binding]; other site 114615004376 ribulose bisophosphate carboxylase; Reviewed; Region: rbcL; PRK04208 114615004377 Ribulose bisphosphate carboxylase large chain, Form I; Region: RuBisCO_large_I; cd08212 114615004378 homodimer interface [polypeptide binding]; other site 114615004379 active site 114615004380 heterodimer interface [polypeptide binding]; other site 114615004381 catalytic residue [active] 114615004382 metal binding site [ion binding]; metal-binding site 114615004383 Ribulose bisphosphate carboxylase/oxygenase (Rubisco), small subunit. Rubisco is a bifunctional enzyme catalyzes the initial steps of two opposing metabolic pathways: photosynthetic carbon fixation and the competing process of photorespiration. Rubisco...; Region: RuBisCO_small; cd03527 114615004384 multimerization interface [polypeptide binding]; other site 114615004385 probable Rubsico expression protein CbbX; Region: cbbX_cfxQ; TIGR02880 114615004386 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes...; Region: AAA; cd00009 114615004387 Walker A motif; other site 114615004388 ATP binding site [chemical binding]; other site 114615004389 Walker B motif; other site 114615004390 arginine finger; other site 114615004391 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others...; Region: HAD_like; cl11391 114615004392 beta-phosphoglucomutase family hydrolase; Region: PGMB-YQAB-SF; TIGR02009 114615004393 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 114615004394 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 114615004395 Peptidase propeptide and YPEB domain; Region: PepSY; pfam03413 114615004396 lysozyme_like domain. This contains several members including Soluble Lytic Transglycosylases (SLT), Goose Egg-White Lysozymes (GEWL), Hen Egg-White Lysozymes (HEWL), chitinases, bacteriophage lambda lysozymes, endolysins, autolysins, and chitosanases...; Region: lysozyme_like; cl00222 114615004397 lysozyme_like domain. This contains several members including Soluble Lytic Transglycosylases (SLT), Goose Egg-White Lysozymes (GEWL), Hen Egg-White Lysozymes (HEWL), chitinases, bacteriophage lambda lysozymes, endolysins, autolysins, and chitosanases...; Region: lysozyme_like; cl00222 114615004398 catalase/hydroperoxidase HPI(I); Provisional; Region: PRK15061 114615004399 N-terminal catalytic domain of catalase-peroxidases; Region: catalase_peroxidase_1; cd00649 114615004400 dimer interface [polypeptide binding]; other site 114615004401 active site 114615004402 heme binding site [chemical binding]; other site 114615004403 C-terminal non-catalytic domain of catalase-peroxidases; Region: catalase_peroxidase_2; cd08200 114615004404 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 114615004405 DNA-binding transcriptional regulator OxyR; Provisional; Region: PRK11151 114615004406 The C-terminal substrate-binding domain of the LysR-type transcriptional regulator OxyR, a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_OxyR; cd08411 114615004407 dimerization interface [polypeptide binding]; other site 114615004408 Uncharacterised protein family (UPF0150); Region: UPF0150; cl00691 114615004409 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 114615004410 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261 114615004411 dimer interface [polypeptide binding]; other site 114615004412 conserved gate region; other site 114615004413 putative PBP binding loops; other site 114615004414 ABC-ATPase subunit interface; other site 114615004415 phosphate transporter permease subunit PtsA; Provisional; Region: pstA; PRK11268 114615004416 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261 114615004417 dimer interface [polypeptide binding]; other site 114615004418 conserved gate region; other site 114615004419 putative PBP binding loops; other site 114615004420 ABC-ATPase subunit interface; other site 114615004421 phosphate transporter ATP-binding protein; Provisional; Region: pstB; PRK10744 114615004422 Phosphate uptake is of fundamental importance in the cell physiology of bacteria because phosphate is required as a nutrient. The Pst system of E. coli comprises four distinct subunits encoded by the pstS, pstA, pstB, and pstC genes. The PstS protein...; Region: ABC_PstB_phosphate_transporter; cd03260 114615004423 Walker A/P-loop; other site 114615004424 ATP binding site [chemical binding]; other site 114615004425 Q-loop/lid; other site 114615004426 ABC transporter signature motif; other site 114615004427 Walker B; other site 114615004428 D-loop; other site 114615004429 H-loop/switch region; other site 114615004430 phosphate transport system regulatory protein PhoU; Region: phoU_full; TIGR02135 114615004431 PhoU domain; Region: PhoU; pfam01895 114615004432 PhoU domain; Region: PhoU; pfam01895 114615004433 phosphate regulon transcriptional regulatory protein PhoB; Region: PhoB; TIGR02154 114615004434 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156 114615004435 active site 114615004436 phosphorylation site [posttranslational modification] 114615004437 intermolecular recognition site; other site 114615004438 dimerization interface [polypeptide binding]; other site 114615004439 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase...; Region: trans_reg_C; cd00383 114615004440 DNA binding site [nucleotide binding] 114615004441 Sel1 repeat; Region: Sel1; cl02723 114615004442 Sel1 repeat; Region: Sel1; cl02723 114615004443 Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic...; Region: Tryp_SPc; cl00149 114615004444 active site 114615004445 High-affinity nickel-transport protein; Region: NicO; cl00964 114615004446 NADH ubiquinone oxidoreductase, 20 Kd subunit; Region: Oxidored_q6; cl00419 114615004447 Respiratory-chain NADH dehydrogenase, 49 Kd subunit; Region: Complex1_49kDa; cl00417 114615004448 hydrogenase (NiFe) small subunit (hydA); Region: hydA; TIGR00391 114615004449 NADH ubiquinone oxidoreductase, 20 Kd subunit; Region: Oxidored_q6; cl00419 114615004450 Respiratory-chain NADH dehydrogenase, 49 Kd subunit; Region: Complex1_49kDa; cl00417 114615004451 Cytochrome b (N-terminus)/b6/petB: Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria...; Region: Cytochrome_b_N; cl00859 114615004452 coenzyme F420-reducing hydrogenase delta subunit (putative coenzyme F420 hydrogenase processing subunit); Region: frhD; TIGR00130 114615004453 Endopeptidases belonging to membrane-bound hydrogenases group. These hydrogenases transfer electrons from H2 to a cytochrome that is bound to a membrane-located complex coupling electron transfer to transmembrane proton translocation. Endopeptidase...; Region: H2MP_MemB-H2up; cd06062 114615004454 putative substrate-binding site; other site 114615004455 nickel binding site [ion binding]; other site 114615004456 HupF/HypC family; Region: HupF_HypC; cl00394 114615004457 HyaE family; HyaE is also called HupG and HoxO. They are proteins serving a critical role in the assembly of multimeric [NiFe] hydrogenases, the enzymes that catalyze the oxidation of molecular hydrogen to enable microorganisms to utilize hydrogen as...; Region: HyaE; cd02965 114615004458 HupH hydrogenase expression protein, C-terminal conserved region; Region: HupH_C; pfam04809 114615004459 Rubredoxin; nonheme iron binding domains containing a [Fe(SCys)4] center. Rubredoxins are small nonheme iron proteins. The iron atom is coordinated by four cysteine residues (Fe(S-Cys)4), but iron can also be replaced by cobalt, nickel or zinc. They...; Region: rubredoxin; cd00730 114615004460 Rubredoxin; Region: Rubredoxin; pfam00301 114615004461 iron binding site [ion binding]; other site 114615004462 Protein of unknown function (DUF3457); Region: DUF3457; cl08122 114615004463 Respiratory-chain NADH dehydrogenase, 49 Kd subunit; Region: Complex1_49kDa; cl00417 114615004464 Hydrogenase expression/synthesis hypA family; Region: HypA; cl00418 114615004465 Ras-like GTPase superfamily. The Ras-like superfamily of small GTPases consists of several families with an extremely high degree of structural and functional similarity. The Ras superfamily is divided into at least four families in eukaryotes: the Ras...; Region: Ras_like_GTPase; cl10444 114615004466 Hydrogenase maturation factor [Posttranslational modification, protein turnover, chaperones]; Region: HypF; COG0068 114615004467 Acylphosphatase; Region: Acylphosphatase; cl00551 114615004468 HypF finger; Region: zf-HYPF; pfam07503 114615004469 HypF finger; Region: zf-HYPF; pfam07503 114615004470 yrdC domain; Region: Sua5_yciO_yrdC; cl00305 114615004471 HupF/HypC family; Region: HupF_HypC; cl00394 114615004472 Hydrogenase formation hypA family; Region: HypD; cl12072 114615004473 Hydrogenase maturation factor [Posttranslational modification, protein turnover, chaperones]; Region: HypD; COG0409 114615004474 HypE (Hydrogenase expression/formation protein). HypE is involved in Ni-Fe hydrogenase biosynthesis. HypE dehydrates its own carbamoyl moiety in an ATP-dependent process to yield the enzyme thiocyanate. The N-terminal domain of HypE is related to the...; Region: HypE; cd02197 114615004475 dimerization interface [polypeptide binding]; other site 114615004476 hydrogenase expression/formation protein HypE; Region: hypE; TIGR02124 114615004477 ATP binding site [chemical binding]; other site 114615004478 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204 114615004479 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156 114615004480 active site 114615004481 phosphorylation site [posttranslational modification] 114615004482 intermolecular recognition site; other site 114615004483 dimerization interface [polypeptide binding]; other site 114615004484 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes...; Region: AAA; cd00009 114615004485 Walker A motif; other site 114615004486 ATP binding site [chemical binding]; other site 114615004487 Walker B motif; other site 114615004488 arginine finger; other site 114615004489 Bacterial regulatory protein, Fis family; Region: HTH_8; cl01091 114615004490 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 114615004491 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 114615004492 putative active site [active] 114615004493 heme pocket [chemical binding]; other site 114615004494 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via trans-...; Region: HisKA; cd00082 114615004495 dimer interface [polypeptide binding]; other site 114615004496 phosphorylation site [posttranslational modification] 114615004497 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 114615004498 ATP binding site [chemical binding]; other site 114615004499 Mg2+ binding site [ion binding]; other site 114615004500 G-X-G motif; other site 114615004501 Formate/nitrite transporter; Region: Form_Nir_trans; cl00927 114615004502 Transcriptional regulators [Transcription]; Region: GntR; COG1802 114615004503 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 114615004504 DNA-binding site [nucleotide binding]; DNA binding site 114615004505 FCD domain; Region: FCD; cl11656 114615004506 Transcriptional regulators [Transcription]; Region: GntR; COG1802 114615004507 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 114615004508 DNA-binding site [nucleotide binding]; DNA binding site 114615004509 FCD domain; Region: FCD; cl11656 114615004510 Protein of unknown function (DUF461); Region: DUF461; cl01071 114615004511 PQQ-dependent dehydrogenase, methanol/ethanol family; Region: PQQ_enz_alc_DH; TIGR03075 114615004512 Dehydrogenases with pyrrolo-quinoline quinone (PQQ) as cofactor, like ethanol, methanol, and membrane bound glucose dehydrogenases. The alignment model contains an 8-bladed beta-propeller; Region: PQQ_DH; cl11493 114615004513 Trp docking motif; other site 114615004514 'Velcro' closure; other site 114615004515 active site 114615004516 coenzyme PQQ synthesis protein PqqA; Provisional; Region: pqqA; cl14189 114615004517 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cl00159 114615004518 [2Fe-2S] binding domain; Region: Fer2_2; pfam01799 114615004519 Aerobic-type carbon monoxide dehydrogenase, large subunit CoxL/CutL homologs [Energy production and conversion]; Region: CoxL; COG1529 114615004520 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 114615004521 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; cl03161 114615004522 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 114615004523 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 114615004524 Bacterial extracellular solute-binding protein, family 7; Region: SBP_bac_7; cl00710 114615004525 Tripartite ATP-independent periplasmic transporters, DctQ component; Region: DctQ; cl01181 114615004526 DctM-like transporters; Region: DctM; pfam06808 114615004527 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl09110 114615004528 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK06187 114615004529 Acyl-protein synthetase, LuxE; Region: LuxE; cl10450 114615004530 Membrane transport protein; Region: Mem_trans; cl09117 114615004531 Thiamine pyrophosphate-requiring enzymes [acetolactate synthase, pyruvate dehydrogenase (cytochrome), glyoxylate carboligase, phosphonopyruvate decarboxylase] [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvB; COG0028 114615004532 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 114615004533 PYR/PP interface [polypeptide binding]; other site 114615004534 dimer interface [polypeptide binding]; other site 114615004535 TPP binding site [chemical binding]; other site 114615004536 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 114615004537 TPP-binding module; composed of proteins similar to benzaldehyde lyase (BZL), oxalyl-CoA decarboxylase (OCoD) and 2-hydroxyphytanoyl-CoA lyase (2-HPCL). Pseudomonas fluorescens biovar I BZL cleaves the acyloin linkage of benzoin producing 2 molecules...; Region: TPP_BZL_OCoD_HPCL; cd02004 114615004538 TPP-binding site; other site 114615004539 dimer interface [polypeptide binding]; other site 114615004540 metabolite-proton symporter; Region: 2A0106; TIGR00883 114615004541 cytochrome o ubiquinol oxidase subunit II; Region: CyoA; TIGR01433 114615004542 Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; cl11412 114615004543 COX Aromatic Rich Motif; Region: COX_ARM; pfam06481 114615004544 Heme/copper-type cytochrome/quinol oxidases, subunit 1 [Energy production and conversion]; Region: CyoB; COG0843 114615004545 Ubiquinol oxidase subunit I. Ubiquinol oxidase, the terminal oxidase in the respiratory chains of aerobic bacteria, is a multi-chain transmembrane protein located in the cell membrane. It catalyzes the reduction of O2 and simultaneously pumps protons...; Region: Ubiquinol_Oxidase_I; cd01662 114615004546 D-pathway; other site 114615004547 Putative ubiquinol binding site [chemical binding]; other site 114615004548 Low-spin heme (heme b) binding site [chemical binding]; other site 114615004549 Putative water exit pathway; other site 114615004550 Binuclear center (heme o3/CuB) [ion binding]; other site 114615004551 K-pathway; other site 114615004552 Putative proton exit pathway; other site 114615004553 Ubiquinol oxidase subunit III subfamily. Ubiquinol oxidase, the terminal oxidase in the respiratory chains of aerobic bacteria, is a multi-chain transmembrane protein located in the cell membrane. It catalyzes the reduction of O2 and simultaneously...; Region: Ubiquinol_oxidase_III; cd02863 114615004554 Subunit I/III interface [polypeptide binding]; other site 114615004555 Subunit III/IV interface [polypeptide binding]; other site 114615004556 Prokaryotic Cytochrome C oxidase subunit IV; Region: COX4_pro; cl01204 114615004557 SURF1 superfamily. Surf1/Shy1 has been implicated in the posttranslational steps of the biogenesis of the mitochondrially-encoded Cox1 subunit of cytochrome c oxidase (complex IV). Cytochrome c oxidase (complex IV), the terminal electron-transferring...; Region: SURF1; cd06662 114615004558 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via trans-...; Region: HisKA; cl00080 114615004559 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 114615004560 ATP binding site [chemical binding]; other site 114615004561 Mg2+ binding site [ion binding]; other site 114615004562 G-X-G motif; other site 114615004563 Response regulator consisting of a CheY-like receiver domain and a Fis-type HTH domain [Signal transduction mechanisms / Transcription]; Region: COG4567 114615004564 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156 114615004565 active site 114615004566 phosphorylation site [posttranslational modification] 114615004567 intermolecular recognition site; other site 114615004568 dimerization interface [polypeptide binding]; other site 114615004569 Bacterial regulatory protein, Fis family; Region: HTH_8; cl01091 114615004570 Uncharacterized protein conserved in bacteria (DUF2130); Region: DUF2130; pfam09903 114615004571 Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841 114615004572 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 114615004573 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 114615004574 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 114615004575 Protein of unknown function (DUF989); Region: DUF989; pfam06181 114615004576 Predicted membrane protein [Function unknown]; Region: COG3748 114615004577 Cytochrome c; Region: Cytochrom_C; cl11414 114615004578 Permease family; Region: Xan_ur_permease; pfam00860 114615004579 Sulfate transporter family; Region: Sulfate_transp; cl00967 114615004580 Aerobic-type carbon monoxide dehydrogenase, small subunit CoxS/CutS homologs [Energy production and conversion]; Region: CoxS; COG2080 114615004581 [2Fe-2S] binding domain; Region: Fer2_2; pfam01799 114615004582 xanthine dehydrogenase subunit XdhA; Provisional; Region: PRK09970 114615004583 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; cl03161 114615004584 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 114615004585 FAD binding domain in molybdopterin dehydrogenase; Region: FAD_binding_5; pfam00941 114615004586 hydroxydechloroatrazine ethylaminohydrolase; Reviewed; Region: PRK08203 114615004587 TRZ/ATZ family contains enzymes from the atrazine degradation pathway and related hydrolases. Atrazine, a chlorinated herbizide, can be catabolized by a variety of different bacteria. The first three steps of the atrazine dehalogenation pathway are...; Region: ATZ_TRZ_like; cd01298 114615004588 active site 114615004589 putative substrate binding pocket [chemical binding]; other site 114615004590 dipeptide transporter ATP-binding subunit; Provisional; Region: dppF; PRK11308 114615004591 The ABC transporter subfamily specific for the transport of dipeptides, oligopeptides (OppD), and nickel (NikDE). The NikABCDE system of E. coli belongs to this family and is composed of the periplasmic binding protein NikA, two integral membrane...; Region: ABC_NikE_OppD_transporters; cd03257 114615004592 Walker A/P-loop; other site 114615004593 ATP binding site [chemical binding]; other site 114615004594 Q-loop/lid; other site 114615004595 ABC transporter signature motif; other site 114615004596 Walker B; other site 114615004597 D-loop; other site 114615004598 H-loop/switch region; other site 114615004599 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 114615004600 dipeptide transporter ATP-binding subunit; Provisional; Region: dppD; PRK11022 114615004601 The ABC transporter subfamily specific for the transport of dipeptides, oligopeptides (OppD), and nickel (NikDE). The NikABCDE system of E. coli belongs to this family and is composed of the periplasmic binding protein NikA, two integral membrane...; Region: ABC_NikE_OppD_transporters; cd03257 114615004602 Walker A/P-loop; other site 114615004603 ATP binding site [chemical binding]; other site 114615004604 Q-loop/lid; other site 114615004605 ABC transporter signature motif; other site 114615004606 Walker B; other site 114615004607 D-loop; other site 114615004608 H-loop/switch region; other site 114615004609 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 114615004610 dipeptide transporter; Provisional; Region: PRK10913 114615004611 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261 114615004612 dimer interface [polypeptide binding]; other site 114615004613 conserved gate region; other site 114615004614 putative PBP binding loops; other site 114615004615 ABC-ATPase subunit interface; other site 114615004616 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 114615004617 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261 114615004618 dimer interface [polypeptide binding]; other site 114615004619 conserved gate region; other site 114615004620 putative PBP binding loops; other site 114615004621 ABC-ATPase subunit interface; other site 114615004622 The substrate-binding component of an ABC-type dipeptide import system contains the type 2 periplasmic binding fold; Region: PBP2_DppA_like; cd08493 114615004623 Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496 114615004624 peptide binding site [polypeptide binding]; other site 114615004625 Uncharacterized ABC-type transport system, periplasmic component/surface lipoprotein [General function prediction only]; Region: Med; COG1744 114615004626 Periplasmic binding domain of the basic membrane lipoprotein Med in Bacillus and its close homologs from other bacteria and Archaea; Region: PBP1_BmpA_Med_like; cd06353 114615004627 putative ligand binding site [chemical binding]; other site 114615004628 Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (; Region: TM_PBP1_transp_TpRbsC_like; cd06580 114615004629 TM-ABC transporter signature motif; other site 114615004630 Transmembrane subunit (TM) of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which are involved in the uptake of branched-chain amino acids (AAs), as well as TMs of transporters involved in the uptake of...; Region: TM_PBP1_branched-chain-AA_like; cl00454 114615004631 Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (; Region: TM_PBP1_transp_TpRbsC_like; cd06580 114615004632 TM-ABC transporter signature motif; other site 114615004633 ABC-type uncharacterized transport systems, ATPase components [General function prediction only]; Region: COG3845 114615004634 This family represents the domain I of the carbohydrate uptake proteins that transport only monosaccharides (Monos). The Carb_Monos family is involved in the uptake of monosaccharides, such as pentoses (such as xylose, arabinose, and ribose) and...; Region: ABC_Carb_Monos_I; cd03216 114615004635 Walker A/P-loop; other site 114615004636 ATP binding site [chemical binding]; other site 114615004637 Q-loop/lid; other site 114615004638 ABC transporter signature motif; other site 114615004639 Walker B; other site 114615004640 D-loop; other site 114615004641 H-loop/switch region; other site 114615004642 This family represents domain II of the carbohydrate uptake proteins that transport only monosaccharides (Monos). The Carb_Monos family is involved in the uptake of monosaccharides, such as pentoses (such as xylose, arabinose, and ribose) and hexoses (; Region: ABC_Carb_Monos_II; cd03215 114615004643 Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285 114615004644 nucleoside/Zn binding site; other site 114615004645 dimer interface [polypeptide binding]; other site 114615004646 catalytic motif [active] 114615004647 Cation efflux family; Region: Cation_efflux; cl00316 114615004648 Domain of unknown function (DUF378); Region: DUF378; cl00943 114615004649 2-keto-3-deoxy-galactonokinase [Carbohydrate transport and metabolism]; Region: DgoK; COG3734 114615004650 2-keto-3-deoxy-galactonokinase; Region: DGOK; pfam05035 114615004651 KDPG and KHG aldolase; Region: KDPG_aldolase; cd00452 114615004652 active site 114615004653 intersubunit interface [polypeptide binding]; other site 114615004654 catalytic residue [active] 114615004655 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 114615004656 Fusaric acid resistance protein family; Region: FUSC; pfam04632 114615004657 Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072 114615004658 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 114615004659 substrate binding pocket [chemical binding]; other site 114615004660 D-3-phosphoglycerate dehydrogenase; Provisional; Region: PRK11790 114615004661 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 114615004662 C-terminal ACT (regulatory) domain of D-3-Phosphoglycerate Dehydrogenase (3PGDH) found in fungi and bacteria; Region: ACT_3PGDH; cd04901 114615004663 L-serine binding site [chemical binding]; other site 114615004664 ACT domain interface; other site 114615004665 TOBE domain; Region: TOBE_2; cl01440 114615004666 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 114615004667 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 114615004668 Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2...; Region: Biotinyl_lipoyl_domains; cl11404 114615004669 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 114615004670 molybdenum ABC transporter, ATP-binding protein; Region: modC_ABC; TIGR02142 114615004671 Walker A/P-loop; other site 114615004672 ATP binding site [chemical binding]; other site 114615004673 Q-loop/lid; other site 114615004674 ABC transporter signature motif; other site 114615004675 Walker B; other site 114615004676 D-loop; other site 114615004677 H-loop/switch region; other site 114615004678 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261 114615004679 dimer interface [polypeptide binding]; other site 114615004680 conserved gate region; other site 114615004681 putative PBP binding loops; other site 114615004682 ABC-ATPase subunit interface; other site 114615004683 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 114615004684 amidase; Provisional; Region: PRK07487 114615004685 GGCT-like domains, also called AIG2-like family. Gamma-glutamyl cyclotransferase (GGCT) catalyzes the formation of pyroglutamic acid (5-oxoproline) from dipeptides containing gamma-glutamyl, and is a dimeric protein. In Homo sapiens, the protein is...; Region: GGCT_like; cl11426 114615004686 M20 Peptidase Aminoacylase 1-like protein 2 aminobenzoyl-glutamate utilization protein B subfamily; Region: M20_Acy1L2_AbgB; cd05673 114615004687 amidohydrolase; Region: amidohydrolases; TIGR01891 114615004688 putative metal binding site [ion binding]; other site 114615004689 NorE_like subfamily of heme-copper oxidase subunit III. Heme-copper oxidases include cytochrome c and ubiquinol oxidases. Alcaligenes faecalis norE is found in a gene cluster containing norCB. norCB encodes the cytochrome c and cytochrome b subunits...; Region: NorE_like; cd02862 114615004690 Subunit I/III interface [polypeptide binding]; other site 114615004691 Cytochrome c; Region: Cytochrom_C; cl11414 114615004692 Heme-copper oxidase subunit I. Heme-copper oxidases are transmembrane protein complexes in the respiratory chains of prokaryotes and mitochondria which catalyze the reduction of O2 and simultaneously pump protons across the membrane. The superfamily...; Region: Heme_Cu_Oxidase_I; cl00275 114615004693 D-pathway; other site 114615004694 Putative water exit pathway; other site 114615004695 K-pathway; other site 114615004696 Binuclear center (active site) [active] 114615004697 Putative proton exit pathway; other site 114615004698 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes...; Region: AAA; cd00009 114615004699 AAA domain (dynein-related subfamily); Region: AAA_5; pfam07728 114615004700 Walker A motif; other site 114615004701 ATP binding site [chemical binding]; other site 114615004702 Walker B motif; other site 114615004703 CbbQ/NirQ/NorQ C-terminal; Region: CbbQ_C; pfam08406 114615004704 Nitric oxide reductase activation protein [Inorganic ion transport and metabolism]; Region: NorD; COG4548 114615004705 norD type: Denitrifying bacteria contain both membrane bound and periplasmic nitrate reductases. Denitrification plays a major role in completing the nitrogen cycle by converting nitrate or nitrite to nitrogen gas. The pathway for microbial...; Region: vWA_norD_type; cd01454 114615004706 metal ion-dependent adhesion site (MIDAS); other site 114615004707 Uncharacterized conserved protein (DUF2267); Region: DUF2267; cl02314 114615004708 N-carbamyl-D-amino acid amidohydrolase (DCase, class 6 nitrilases); Region: DCase; cd07569 114615004709 Predicted amidohydrolase [General function prediction only]; Region: COG0388 114615004710 tetramer interface [polypeptide binding]; other site 114615004711 active site 114615004712 catalytic triad [active] 114615004713 dimer interface [polypeptide binding]; other site 114615004714 Phosphoribosyl transferase domain; Region: Pribosyltran; cl00309 114615004715 Protein of unknown function (DUF1688); Region: DUF1688; pfam07958 114615004716 hypothetical protein; Validated; Region: PRK07198 114615004717 GTP cyclohydrolase N terminal; Region: GTP_CH_N; pfam12471 114615004718 GTP cyclohydrolase II (RibA). GTP cyclohydrolase II catalyzes the conversion of GTP to 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5' phosphate, formate, pyrophosphate (APy), and GMP in the biosynthetic pathway of riboflavin. Riboflavin is the...; Region: GTP_cyclohydro2; cd00641 114615004719 dimerization interface [polypeptide binding]; other site 114615004720 active site 114615004721 cytosine deaminase; Provisional; Region: PRK05985 114615004722 Bacterial cytosine deaminase and related metal-dependent hydrolases. Cytosine deaminases (CDs) catalyze the deamination of cytosine, producing uracil and ammonia. They play an important role in pyrimidine salvage. CDs are present in prokaryotes and...; Region: Bact_CD; cd01293 114615004723 active site 114615004724 N-carbamyl-D-amino acid amidohydrolase (DCase, class 6 nitrilases); Region: DCase; cd07569 114615004725 Predicted amidohydrolase [General function prediction only]; Region: COG0388 114615004726 tetramer interface [polypeptide binding]; other site 114615004727 active site 114615004728 catalytic triad [active] 114615004729 dimer interface [polypeptide binding]; other site 114615004730 Asp/Glu/Hydantoin racemase; Region: Asp_Glu_race; cl00518 114615004731 dihydropyrimidinase; Provisional; Region: PRK13404 114615004732 D-hydantoinases (D-HYD) also called dihydropyrimidases (DHPase) and related proteins; DHPases are a family of enzymes that catalyze the reversible hydrolytic ring opening of the amide bond in five- or six-membered cyclic diamides, like...; Region: D-HYD; cd01314 114615004733 tetramer interface [polypeptide binding]; other site 114615004734 active site 114615004735 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 114615004736 extended (e) SDRs; Region: SDR_e; cd08946 114615004737 NAD(P) binding site [chemical binding]; other site 114615004738 active site 114615004739 substrate binding site [chemical binding]; other site 114615004740 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK05565 114615004741 classical (c) SDRs; Region: SDR_c; cd05233 114615004742 NAD(P) binding site [chemical binding]; other site 114615004743 active site 114615004744 DNA-binding transcriptional regulator LysR; Provisional; Region: PRK11013 114615004745 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 114615004746 The C-terminal substrate-domain of LysR-type transcriptional regulators involved in the catabolism of opines and that of related regulators, contains the type 2 periplasmic binding fold; Region: PBP2_LysR_opines_like; cd08415 114615004747 putative dimerization interface [polypeptide binding]; other site 114615004748 Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072 114615004749 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 114615004750 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_7; cd08512 114615004751 Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496 114615004752 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 114615004753 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261 114615004754 dimer interface [polypeptide binding]; other site 114615004755 conserved gate region; other site 114615004756 putative PBP binding loops; other site 114615004757 ABC-ATPase subunit interface; other site 114615004758 nickel ABC transporter, permease subunit NikC; Region: nickel_nikC; TIGR02790 114615004759 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261 114615004760 dimer interface [polypeptide binding]; other site 114615004761 conserved gate region; other site 114615004762 putative PBP binding loops; other site 114615004763 ABC-ATPase subunit interface; other site 114615004764 ATPase components of various ABC-type transport systems, contain duplicated ATPase [General function prediction only]; Region: COG1123 114615004765 The ABC transporter subfamily specific for the transport of dipeptides, oligopeptides (OppD), and nickel (NikDE). The NikABCDE system of E. coli belongs to this family and is composed of the periplasmic binding protein NikA, two integral membrane...; Region: ABC_NikE_OppD_transporters; cd03257 114615004766 Walker A/P-loop; other site 114615004767 ATP binding site [chemical binding]; other site 114615004768 Q-loop/lid; other site 114615004769 ABC transporter signature motif; other site 114615004770 Walker B; other site 114615004771 D-loop; other site 114615004772 H-loop/switch region; other site 114615004773 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 114615004774 The ABC transporter subfamily specific for the transport of dipeptides, oligopeptides (OppD), and nickel (NikDE). The NikABCDE system of E. coli belongs to this family and is composed of the periplasmic binding protein NikA, two integral membrane...; Region: ABC_NikE_OppD_transporters; cd03257 114615004775 Walker A/P-loop; other site 114615004776 ATP binding site [chemical binding]; other site 114615004777 Q-loop/lid; other site 114615004778 ABC transporter signature motif; other site 114615004779 Walker B; other site 114615004780 D-loop; other site 114615004781 H-loop/switch region; other site 114615004782 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 114615004783 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 114615004784 FAD binding domain; Region: FAD_binding_4; pfam01565 114615004785 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 114615004786 putative substrate translocation pore; other site 114615004787 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 114615004788 mannonate dehydratase; Region: uxuA; TIGR00695 114615004789 mannonate dehydratase; Provisional; Region: PRK03906 114615004790 L-idonate 5-dehydrogenase; Provisional; Region: PRK09880 114615004791 L-idonate 5-dehydrogenase; Region: idonate-5-DH; cd08232 114615004792 putative NAD(P) binding site [chemical binding]; other site 114615004793 catalytic Zn binding site [ion binding]; other site 114615004794 2-keto-3-deoxygluconate kinase (KdgK) phosphorylates 2-keto-3-deoxygluconate (KDG) to form 2-keto-3-deoxy-6-phosphogluconate (KDGP). KDG is the common intermediate product, that allows organisms to channel D-glucuronate and/or D-galacturinate into the...; Region: KdgK; cd01166 114615004795 substrate binding site [chemical binding]; other site 114615004796 ATP binding site [chemical binding]; other site 114615004797 keto-hydroxyglutarate-aldolase/keto-deoxy- phosphogluconate aldolase; Provisional; Region: PRK05718 114615004798 KDPG and KHG aldolase; Region: KDPG_aldolase; cd00452 114615004799 active site 114615004800 intersubunit interface [polypeptide binding]; other site 114615004801 catalytic residue [active] 114615004802 Periplasmic binding domain of ABC-type YtfQ-like transport systems; Region: PBP1_YtfQ_like; cd06309 114615004803 putative ligand binding site [chemical binding]; other site 114615004804 ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129 114615004805 This family represents the domain I of the carbohydrate uptake proteins that transport only monosaccharides (Monos). The Carb_Monos family is involved in the uptake of monosaccharides, such as pentoses (such as xylose, arabinose, and ribose) and...; Region: ABC_Carb_Monos_I; cd03216 114615004806 Walker A/P-loop; other site 114615004807 ATP binding site [chemical binding]; other site 114615004808 Q-loop/lid; other site 114615004809 ABC transporter signature motif; other site 114615004810 Walker B; other site 114615004811 D-loop; other site 114615004812 H-loop/switch region; other site 114615004813 This family represents domain II of the carbohydrate uptake proteins that transport only monosaccharides (Monos). The Carb_Monos family is involved in the uptake of monosaccharides, such as pentoses (such as xylose, arabinose, and ribose) and hexoses (; Region: ABC_Carb_Monos_II; cd03215 114615004814 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 114615004815 TM-ABC transporter signature motif; other site 114615004816 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 114615004817 TM-ABC transporter signature motif; other site 114615004818 Transcriptional regulators [Transcription]; Region: FadR; COG2186 114615004819 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 114615004820 DNA-binding site [nucleotide binding]; DNA binding site 114615004821 FCD domain; Region: FCD; cl11656 114615004822 dihydroxy-acid dehydratase; Provisional; Region: PRK13017 114615004823 Dehydratase family; Region: ILVD_EDD; cl00340 114615004824 Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329 114615004825 Dihydrodipicolinate synthase family; Region: DHDPS-like; cd00408 114615004826 inhibitor site; inhibition site 114615004827 active site 114615004828 dimer interface [polypeptide binding]; other site 114615004829 catalytic residue [active] 114615004830 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 114615004831 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 114615004832 Galactose mutarotase and related enzymes [Carbohydrate transport and metabolism]; Region: GalM; COG2017 114615004833 galactose mutarotase_like; Region: galactose_mutarotase_like; cd09019 114615004834 active site 114615004835 catalytic residues [active] 114615004836 SMP-30/Gluconolaconase/LRE-like region; Region: SGL; pfam08450 114615004837 Periplasmic xylose-binding component of the ABC-type transport systems that belong to a family of pentose/hexose sugar-binding proteins of the type I periplasmic binding protein (PBP1) superfamily; Region: PBP1_ABC_xylose_binding; cd01538 114615004838 putative ligand binding site [chemical binding]; other site 114615004839 xylose transporter ATP-binding subunit; Provisional; Region: PRK13549 114615004840 This family represents the domain I of the carbohydrate uptake proteins that transport only monosaccharides (Monos). The Carb_Monos family is involved in the uptake of monosaccharides, such as pentoses (such as xylose, arabinose, and ribose) and...; Region: ABC_Carb_Monos_I; cd03216 114615004841 Walker A/P-loop; other site 114615004842 ATP binding site [chemical binding]; other site 114615004843 Q-loop/lid; other site 114615004844 ABC transporter signature motif; other site 114615004845 Walker B; other site 114615004846 D-loop; other site 114615004847 H-loop/switch region; other site 114615004848 This family represents domain II of the carbohydrate uptake proteins that transport only monosaccharides (Monos). The Carb_Monos family is involved in the uptake of monosaccharides, such as pentoses (such as xylose, arabinose, and ribose) and hexoses (; Region: ABC_Carb_Monos_II; cd03215 114615004849 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 114615004850 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 114615004851 TM-ABC transporter signature motif; other site 114615004852 Response regulator receiver domain; Region: Response_reg; pfam00072 114615004853 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156 114615004854 active site 114615004855 phosphorylation site [posttranslational modification] 114615004856 intermolecular recognition site; other site 114615004857 dimerization interface [polypeptide binding]; other site 114615004858 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 114615004859 Chemotaxis protein histidine kinase and related kinases [Cell motility and secretion / Signal transduction mechanisms]; Region: CheA; COG0643 114615004860 putative binding surface; other site 114615004861 active site 114615004862 Signal transducing histidine kinase, homodimeric domain; Region: H-kinase_dim; pfam02895 114615004863 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 114615004864 ATP binding site [chemical binding]; other site 114615004865 Mg2+ binding site [ion binding]; other site 114615004866 G-X-G motif; other site 114615004867 CheA regulatory domain; CheA is a histidine protein kinase present in bacteria and archea. Activated by the chemotaxis receptor a histidine phosphoryl group from CheA is passed directly to an aspartate in the response regulator CheY. This signalling...; Region: CheA_reg; cd00731 114615004868 CheW, a small regulator protein, unique to the chemotaxis signalling in prokaryotes and archea. CheW interacts with the histidine kinase CheA, most likely with the related regulatory domain of CheA. CheW is proposed to form signalling arrays together...; Region: CheW; cd00732 114615004869 putative CheA interaction surface; other site 114615004870 FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202 114615004871 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 114615004872 FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202 114615004873 putative active site [active] 114615004874 heme pocket [chemical binding]; other site 114615004875 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 114615004876 putative active site [active] 114615004877 heme pocket [chemical binding]; other site 114615004878 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 114615004879 Taxis toward Aspartate and Related amino acids and Homologs (TarH). The Tar chemoreceptor of Escherichia coli mediates attractant responses to aspartate, maltose, and phenol, repellent responses to Ni2+ and Co2+, and thermoresponses. These...; Region: TarH; cl00144 114615004880 CheR methyltransferase, all-alpha domain; Region: CheR_N; pfam03705 114615004881 Methyltransferase, chemotaxis proteins; Region: MeTrc; smart00138 114615004882 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cl12011 114615004883 CheD chemotactic sensory transduction; Region: CheD; cl00810 114615004884 chemotaxis-specific methylesterase; Provisional; Region: PRK00742 114615004885 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156 114615004886 active site 114615004887 phosphorylation site [posttranslational modification] 114615004888 intermolecular recognition site; other site 114615004889 dimerization interface [polypeptide binding]; other site 114615004890 CheB methylesterase; Region: CheB_methylest; pfam01339 114615004891 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 114615004892 anti sigma factor interaction site; other site 114615004893 regulatory phosphorylation site [posttranslational modification]; other site 114615004894 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156 114615004895 Response regulator receiver domain; Region: Response_reg; pfam00072 114615004896 active site 114615004897 phosphorylation site [posttranslational modification] 114615004898 intermolecular recognition site; other site 114615004899 dimerization interface [polypeptide binding]; other site 114615004900 Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cl00120 114615004901 putative diguanylate cyclase; Provisional; Region: PRK09776 114615004902 Motif C-terminal to PAS motifs (likely to contribute to PAS structural domain); Region: PAC; smart00086 114615004903 PAS fold; Region: PAS_7; pfam12860 114615004904 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via trans-...; Region: HisKA; cd00082 114615004905 dimer interface [polypeptide binding]; other site 114615004906 phosphorylation site [posttranslational modification] 114615004907 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 114615004908 ATP binding site [chemical binding]; other site 114615004909 Mg2+ binding site [ion binding]; other site 114615004910 G-X-G motif; other site 114615004911 Response regulator receiver domain; Region: Response_reg; pfam00072 114615004912 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156 114615004913 active site 114615004914 phosphorylation site [posttranslational modification] 114615004915 intermolecular recognition site; other site 114615004916 dimerization interface [polypeptide binding]; other site 114615004917 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cl00125 114615004918 active site residue [active] 114615004919 Member of the Rhodanese Homology Domain superfamily, repeat 2. This CD includes putative rhodanese-related sulfurtransferases which contain 4 copies of the Rhodanese Homology Domain. This CD aligns the 2nd repeat which does contain the putative...; Region: 4RHOD_Repeat_2; cd01533 114615004920 active site residue [active] 114615004921 Member of the Rhodanese Homology Domain superfamily, repeat 3. This CD includes putative rhodanese-related sulfurtransferases which contain 4 copies of the Rhodanese Homology Domain. This CD aligns the 3rd repeat which does not contain the putative...; Region: 4RHOD_Repeat_3; cd01534 114615004922 active site residue [active] 114615004923 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cl00125 114615004924 active site residue [active] 114615004925 Cysteine dioxygenase type I; Region: CDO_I; cl02350 114615004926 Monoamine oxidase [Amino acid transport and metabolism]; Region: COG1231 114615004927 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 114615004928 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes...; Region: AAA; cd00009 114615004929 Walker A motif; other site 114615004930 ATP binding site [chemical binding]; other site 114615004931 Walker B motif; other site 114615004932 proteasome-activating nucleotidase; Provisional; Region: PRK03992 114615004933 arginine finger; other site 114615004934 glutathionine S-transferase; Provisional; Region: PRK10542 114615004935 GST_N family, Class Beta subfamily; GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of endogenous and xenobiotic alkylating agents, including carcinogens...; Region: GST_N_Beta; cd03057 114615004936 C-terminal domain interface [polypeptide binding]; other site 114615004937 GSH binding site (G-site) [chemical binding]; other site 114615004938 dimer interface [polypeptide binding]; other site 114615004939 C-terminal, alpha helical domain of Class Beta Glutathione S-transferases; Region: GST_C_Beta; cd03188 114615004940 dimer interface [polypeptide binding]; other site 114615004941 substrate binding pocket (H-site) [chemical binding]; other site 114615004942 N-terminal domain interface [polypeptide binding]; other site 114615004943 Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1)...; Region: Rieske; cl00938 114615004944 iron-sulfur cluster [ion binding]; other site 114615004945 [2Fe-2S] cluster binding site [ion binding]; other site 114615004946 GlpE sulfurtransferase (ST) and homologs are members of the Rhodanese Homology Domain superfamily. Unlike other rhodanese sulfurtransferases, GlpE is a single domain protein but indications are that it functions as a dimer. The active site contains a...; Region: GlpE_ST; cd01444 114615004947 active site residue [active] 114615004948 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 114615004949 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 114615004950 This family is the oxydase domain of NRPS (non-ribosomal peptide synthetase) and other proteins that modify polypeptides by cyclizing a thioester to form a ring. These include epoB, part of the epothilone biosynthesis pathway; tubD, part of the...; Region: mcbC-like_oxidoreductase; cd02142 114615004951 NADPH bind site [chemical binding]; other site 114615004952 This family is the oxydase domain of NRPS (non-ribosomal peptide synthetase) and other proteins that modify polypeptides by cyclizing a thioester to form a ring. These include epoB, part of the epothilone biosynthesis pathway; tubD, part of the...; Region: mcbC-like_oxidoreductase; cd02142 114615004953 putative FMN binding site [chemical binding]; other site 114615004954 NADPH bind site [chemical binding]; other site 114615004955 Flavodoxin reductases (ferredoxin-NADPH reductases) family 1 [Energy production and conversion]; Region: Hmp; COG1018 114615004956 Phthalate dioxygenase reductase (PDR) is an FMN-dependent reductase that mediates electron transfer from NADH to FMN to an iron sulfur cluster. PDR has an an N-terminal ferrredoxin reductase (FNR)-like NAD(H) binding domain and a C-terminal iron-...; Region: PDR_like; cd06185 114615004957 FMN-binding pocket [chemical binding]; other site 114615004958 flavin binding motif; other site 114615004959 phosphate binding motif [ion binding]; other site 114615004960 beta-alpha-beta structure motif; other site 114615004961 NAD binding pocket [chemical binding]; other site 114615004962 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 114615004963 catalytic loop [active] 114615004964 iron binding site [ion binding]; other site 114615004965 protocatechuate 4,5-dioxygenase; Provisional; Region: PRK13367 114615004966 Subunit B of Class III Extradiol ring-cleavage dioxygenases; Region: Extradiol_Dioxygenase_3B_like; cl00599 114615004967 active site 114615004968 metal binding site [ion binding]; metal-binding site 114615004969 The C-terminal domain of Gallate Dioxygenase, which catalyzes the oxidization and subsequent ring-opening of gallate; Region: Gallate_dioxygenase_C; cd07923 114615004970 putative dimer interface [polypeptide binding]; other site 114615004971 putative N- and C-terminal domain interface [polypeptide binding]; other site 114615004972 Transcriptional regulator [Transcription]; Region: LysR; COG0583 114615004973 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 114615004974 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 114615004975 putative effector binding pocket; other site 114615004976 dimerization interface [polypeptide binding]; other site 114615004977 Transcriptional regulator [Transcription]; Region: LysR; COG0583 114615004978 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 114615004979 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator similar to DntR, which is involved in the catabolism of dinitrotoluene; contains the type 2 periplasmic binding fold; Region: PBP2_DntR_like_2; cd08464 114615004980 putative substrate binding pocket [chemical binding]; other site 114615004981 putative dimerization interface [polypeptide binding]; other site 114615004982 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cl00220 114615004983 catalytic triad [active] 114615004984 conserved cis-peptide bond; other site 114615004985 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cl12011 114615004986 Escherichia coli PhnB and similar proteins; the E. coli phnB gene is found next to an operon involved in the cleavage of carbon-phosphorus bonds in unactivated alkylphosphonates; Region: PhnB_like; cd06588 114615004987 dimer interface [polypeptide binding]; other site 114615004988 Peptidase family M23; Region: Peptidase_M23; pfam01551 114615004989 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 114615004990 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 114615004991 DNA-binding site [nucleotide binding]; DNA binding site 114615004992 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 114615004993 pyridoxal 5'-phosphate binding site [chemical binding]; other site 114615004994 homodimer interface [polypeptide binding]; other site 114615004995 catalytic residue [active] 114615004996 Uncharacterized Fe-S protein [General function prediction only]; Region: COG3217 114615004997 MOSC N-terminal beta barrel domain; Region: MOSC_N; pfam03476 114615004998 MOSC domain; Region: MOSC; pfam03473 114615004999 Rubredoxin; nonheme iron binding domains containing a [Fe(SCys)4] center. Rubredoxins are small nonheme iron proteins. The iron atom is coordinated by four cysteine residues (Fe(S-Cys)4), but iron can also be replaced by cobalt, nickel or zinc. They...; Region: rubredoxin; cd00730 114615005000 Rubredoxin; Region: Rubredoxin; pfam00301 114615005001 iron binding site [ion binding]; other site 114615005002 ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683 114615005003 Periplasmic component (FmdD) of an active transport system for short-chain amides and urea (FmdDEF); Region: PBP1_FmdD_like; cd06355 114615005004 putative ligand binding site [chemical binding]; other site 114615005005 Group II intron, maturase-specific domain; Region: GIIM; pfam08388 114615005006 Putative lumazine-binding; Region: Lumazine_bd_2; pfam12893 114615005007 Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638 114615005008 Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1)...; Region: Rieske; cl00938 114615005009 iron-sulfur cluster [ion binding]; other site 114615005010 [2Fe-2S] cluster binding site [ion binding]; other site 114615005011 C-terminal catalytic domain of the oxygenase alpha subunit of dicamba O-demethylase and related aromatic ring hydroxylating dioxygenases; Region: RHO_alpha_C_DMO-like; cd08878 114615005012 alpha subunit interface [polypeptide binding]; other site 114615005013 active site 114615005014 substrate binding site [chemical binding]; other site 114615005015 Fe binding site [ion binding]; other site 114615005016 Transcriptional regulators [Transcription]; Region: FadR; COG2186 114615005017 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 114615005018 DNA-binding site [nucleotide binding]; DNA binding site 114615005019 FCD domain; Region: FCD; cl11656 114615005020 Flavodoxin reductases (ferredoxin-NADPH reductases) family 1 [Energy production and conversion]; Region: Hmp; COG1018 114615005021 Phthalate dioxygenase reductase (PDR) is an FMN-dependent reductase that mediates electron transfer from NADH to FMN to an iron sulfur cluster. PDR has an an N-terminal ferrredoxin reductase (FNR)-like NAD(H) binding domain and a C-terminal iron-...; Region: PDR_like; cd06185 114615005022 FMN-binding pocket [chemical binding]; other site 114615005023 flavin binding motif; other site 114615005024 phosphate binding motif [ion binding]; other site 114615005025 beta-alpha-beta structure motif; other site 114615005026 NAD binding pocket [chemical binding]; other site 114615005027 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 114615005028 catalytic loop [active] 114615005029 iron binding site [ion binding]; other site 114615005030 methionine synthase; Provisional; Region: PRK01207 114615005031 C-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme catalyses the last step in the production of methionine by...; Region: CIMS_C_terminal_like; cd03311 114615005032 substrate binding site [chemical binding]; other site 114615005033 THF binding site; other site 114615005034 zinc-binding site [ion binding]; other site 114615005035 Acetokinase family; Region: Acetate_kinase; cl01029 114615005036 choline dehydrogenase; Validated; Region: PRK02106 114615005037 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 114615005038 porphobilinogen deaminase; Reviewed; Region: hemC; PRK00072 114615005039 Hydroxymethylbilane synthase (HMBS), also known as porphobilinogen deaminase (PBGD), is an intermediate enzyme in the biosynthetic pathway of tetrapyrrolic ring systems, such as heme, chlorophylls, and vitamin B12. HMBS catalyzes the conversion of...; Region: HMBS; cl03189 114615005040 domain interfaces; other site 114615005041 active site 114615005042 methylcobalamin:coenzyme M methyltransferase; Validated; Region: PRK06252 114615005043 Uroporphyrinogen decarboxylase (URO-D) is a dimeric cytosolic enzyme that decarboxylates the four acetate side chains of uroporphyrinogen III (uro-III) to create coproporphyrinogen III, without requiring any prosthetic groups or cofactors. This...; Region: URO-D; cd00717 114615005044 substrate binding site [chemical binding]; other site 114615005045 active site 114615005046 Cache domain; Region: Cache_1; pfam02743 114615005047 PAS domain S-box; Region: sensory_box; TIGR00229 114615005048 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 114615005049 putative active site [active] 114615005050 heme pocket [chemical binding]; other site 114615005051 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 114615005052 metal binding site [ion binding]; metal-binding site 114615005053 active site 114615005054 I-site; other site 114615005055 SlyX; Region: SlyX; cl01090 114615005056 Predicted sulfurtransferase [General function prediction only]; Region: COG1054 114615005057 Member of the Rhodanese Homology Domain superfamily. This CD includes Escherichia coli YceA, Bacillus subtilis YbfQ, and similar uncharacterized proteins; Region: RHOD_YceA; cd01518 114615005058 active site residue [active] 114615005059 Gamma-glutamyltransferase [Amino acid transport and metabolism]; Region: Ggt; cl08040 114615005060 Gamma-glutamyltranspeptidase; Region: G_glu_transpept; pfam01019 114615005061 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; cl11587 114615005062 CsbD-like; Region: CsbD; cl01272 114615005063 Cupin domain; Region: Cupin_2; cl09118 114615005064 Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534 114615005065 MatE; Region: MatE; cl10513 114615005066 Dolichyl-phosphate-mannose--protein O-mannosyl transferase [Posttranslational modification, protein turnover, chaperones]; Region: PMT1; COG1928 114615005067 Dolichyl-phosphate-mannose--protein O-mannosyl transferase [Posttranslational modification, protein turnover, chaperones]; Region: PMT1; COG1928 114615005068 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 114615005069 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via trans-...; Region: HisKA; cd00082 114615005070 dimer interface [polypeptide binding]; other site 114615005071 phosphorylation site [posttranslational modification] 114615005072 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 114615005073 ATP binding site [chemical binding]; other site 114615005074 Mg2+ binding site [ion binding]; other site 114615005075 G-X-G motif; other site 114615005076 Response regulator receiver domain; Region: Response_reg; pfam00072 114615005077 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156 114615005078 active site 114615005079 phosphorylation site [posttranslational modification] 114615005080 intermolecular recognition site; other site 114615005081 dimerization interface [polypeptide binding]; other site 114615005082 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 114615005083 ligand binding site [chemical binding]; other site 114615005084 Protein of unknown function (DUF1006); Region: DUF1006; pfam06224 114615005085 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3214 114615005086 transcriptional repressor BetI; Region: betaine_BetI; TIGR03384 114615005087 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 114615005088 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 114615005089 Protein of unknown function (DUF2809); Region: DUF2809; pfam10990 114615005090 4-hydroxyphenylacetate permease; Region: HpaX; TIGR02332 114615005091 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 114615005092 putative substrate translocation pore; other site 114615005093 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 114615005094 Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841 114615005095 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 114615005096 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 114615005097 Flavin Reductases; Region: FlaRed; cl00801 114615005098 Brown fat-inducible thioesterase (BFIT). Brain acyl-CoA hydrolase (BACH). These enzymes deacylate long-chain fatty acids by hydrolyzing acyl-CoA thioesters to free fatty acids and CoA-SH. Eukaryotic members of this family are expressed in brain...; Region: BFIT_BACH; cd03442 114615005099 DNA-binding transcriptional repressor GlpR; Provisional; Region: PRK10906 114615005100 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 114615005101 SugarP_isomerase: Sugar Phosphate Isomerase family; includes type A ribose 5-phosphate isomerase (RPI_A), glucosamine-6-phosphate (GlcN6P) deaminase, and 6-phosphogluconolactonase (6PGL). RPI catalyzes the reversible conversion of ribose-5-phosphate to...; Region: SugarP_isomerase; cl00339 114615005102 glycerol-3-phosphate dehydrogenase; Reviewed; Region: glpD; PRK12266 114615005103 Malate:quinone oxidoreductase (Mqo); Region: Mqo; cl14881 114615005104 ABC-type sugar transport systems, ATPase components [Carbohydrate transport and metabolism]; Region: MalK; COG3839 114615005105 ABC Carbohydrate and Solute Transporters-like subgroup. This family is comprised of proteins involved in the transport of apparently unrelated solutes and proteins specific for di- and oligosaccharides and polyols. ABC transporters are a large family...; Region: ABC_Carb_Solutes_like; cd03259 114615005106 Walker A/P-loop; other site 114615005107 ATP binding site [chemical binding]; other site 114615005108 Q-loop/lid; other site 114615005109 ABC transporter signature motif; other site 114615005110 Walker B; other site 114615005111 D-loop; other site 114615005112 H-loop/switch region; other site 114615005113 ABC-type sugar transport systems, ATPase components [Carbohydrate transport and metabolism]; Region: MalK; COG3839 114615005114 ABC Carbohydrate and Solute Transporters-like subgroup. This family is comprised of proteins involved in the transport of apparently unrelated solutes and proteins specific for di- and oligosaccharides and polyols. ABC transporters are a large family...; Region: ABC_Carb_Solutes_like; cd03259 114615005115 Walker A/P-loop; other site 114615005116 ATP binding site [chemical binding]; other site 114615005117 Q-loop/lid; other site 114615005118 ABC transporter signature motif; other site 114615005119 Walker B; other site 114615005120 D-loop; other site 114615005121 H-loop/switch region; other site 114615005122 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 114615005123 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261 114615005124 dimer interface [polypeptide binding]; other site 114615005125 conserved gate region; other site 114615005126 putative PBP binding loops; other site 114615005127 ABC-ATPase subunit interface; other site 114615005128 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261 114615005129 dimer interface [polypeptide binding]; other site 114615005130 conserved gate region; other site 114615005131 putative PBP binding loops; other site 114615005132 ABC-ATPase subunit interface; other site 114615005133 Predicted small integral membrane protein (DUF2160); Region: DUF2160; cl02294 114615005134 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 114615005135 MotA/TolQ/ExbB proton channel family; Region: MotA_ExbB; cl00568 114615005136 Biopolymer transport proteins [Intracellular trafficking and secretion]; Region: TolQ; COG0811 114615005137 Biopolymer transport protein ExbD/TolR; Region: ExbD; cl00537 114615005138 Gram-negative bacterial tonB protein; Region: TonB; cl10048 114615005139 EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading...; Region: EFh; cd00051 114615005140 Ca2+ binding site [ion binding]; other site 114615005141 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 114615005142 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156 114615005143 active site 114615005144 phosphorylation site [posttranslational modification] 114615005145 intermolecular recognition site; other site 114615005146 dimerization interface [polypeptide binding]; other site 114615005147 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors...; Region: LuxR_C_like; cd06170 114615005148 DNA binding residues [nucleotide binding] 114615005149 dimerization interface [polypeptide binding]; other site 114615005150 Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629 114615005151 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 114615005152 N-terminal plug; other site 114615005153 ligand-binding site [chemical binding]; other site 114615005154 NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902 114615005155 Old yellow enzyme (OYE)-like FMN binding domain. OYE was the first flavin-dependent enzyme identified, however its true physiological role remains elusive to this day. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a...; Region: OYE_like_FMN; cd02933 114615005156 FMN binding site [chemical binding]; other site 114615005157 active site 114615005158 substrate binding site [chemical binding]; other site 114615005159 catalytic residue [active] 114615005160 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: RbsB; COG1879 114615005161 Periplasmic sugar-binding component of uncharacterized ABC-type transport systems that are members of the pentose/hexose sugar-binding protein family of the type I periplasmic binding protein superfamily; Region: PBP1_ABC_sugar_binding_like_1; cd06300 114615005162 putative ligand binding site [chemical binding]; other site 114615005163 ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129 114615005164 This family represents the domain I of the carbohydrate uptake proteins that transport only monosaccharides (Monos). The Carb_Monos family is involved in the uptake of monosaccharides, such as pentoses (such as xylose, arabinose, and ribose) and...; Region: ABC_Carb_Monos_I; cd03216 114615005165 Walker A/P-loop; other site 114615005166 ATP binding site [chemical binding]; other site 114615005167 Q-loop/lid; other site 114615005168 ABC transporter signature motif; other site 114615005169 Walker B; other site 114615005170 D-loop; other site 114615005171 H-loop/switch region; other site 114615005172 This family represents domain II of the carbohydrate uptake proteins that transport only monosaccharides (Monos). The Carb_Monos family is involved in the uptake of monosaccharides, such as pentoses (such as xylose, arabinose, and ribose) and hexoses (; Region: ABC_Carb_Monos_II; cd03215 114615005173 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 114615005174 TM-ABC transporter signature motif; other site 114615005175 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 114615005176 TM-ABC transporter signature motif; other site 114615005177 Domain of unknown function (DUF1993); Region: DUF1993; cl01567 114615005178 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 114615005179 NAD(P) binding site [chemical binding]; other site 114615005180 active site 114615005181 4-Oxalocrotonate Tautomerase: Catalyzes the isomerization of unsaturated ketones. The structure is a homohexamer that is arranged as a trimer of dimers. The hexamer contains six active sites, each formed by residues from three monomers, two from one...; Region: 4Oxalocrotonate_Tautomerase; cl00235 114615005182 lysozyme_like domain. This contains several members including Soluble Lytic Transglycosylases (SLT), Goose Egg-White Lysozymes (GEWL), Hen Egg-White Lysozymes (HEWL), chitinases, bacteriophage lambda lysozymes, endolysins, autolysins, and chitosanases...; Region: lysozyme_like; cl00222 114615005183 lytic murein transglycosylase; Region: MltB_2; TIGR02283 114615005184 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 114615005185 phosphoglucomutase; Validated; Region: PRK07564 114615005186 This bacterial PGM-like (phosphoglucomutase-like) protein of unknown function belongs to the alpha-D-phosphohexomutase superfamily. The alpha-D-phosphohexomutases include several related enzymes that catalyze a reversible intramolecular phosphoryl...; Region: PGM_like3; cd05801 114615005187 active site 114615005188 substrate binding site [chemical binding]; other site 114615005189 metal binding site [ion binding]; metal-binding site 114615005190 alpha-ketoglutarate decarboxylase; Reviewed; Region: kgd; PRK12270 114615005191 Glutathione-dependent formaldehyde dehydrogenase related proteins, child 1; Region: FDH_like_1; cd08283 114615005192 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 114615005193 NAD binding site [chemical binding]; other site 114615005194 catalytic Zn binding site [ion binding]; other site 114615005195 structural Zn binding site [ion binding]; other site 114615005196 Flp pilus assembly protein TadG [Intracellular trafficking and secretion]; Region: TadG; COG4961 114615005197 Membrane glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: MdoH; COG2943 114615005198 Glucan_BSP_ModH catalyzes the elongation of beta-1,2 polyglucose chains of glucan; Region: Glucan_BSP_ModH; cd04191 114615005199 Ligand binding site [chemical binding]; other site 114615005200 DXD motif; other site 114615005201 Periplasmic glucan biosynthesis protein, MdoG; Region: MdoG; cl01208 114615005202 Transposase domain (DUF772); Region: DUF772; cl12084 114615005203 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 114615005204 DNA-binding transcriptional activator GcvA; Provisional; Region: PRK11139 114615005205 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 114615005206 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 114615005207 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 114615005208 non-specific DNA binding site [nucleotide binding]; other site 114615005209 salt bridge; other site 114615005210 sequence-specific DNA binding site [nucleotide binding]; other site 114615005211 Predicted transcriptional regulator [General function prediction only]; Region: COG3800 114615005212 Predicted transcriptional regulator (DUF2083); Region: DUF2083; pfam09856 114615005213 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 114615005214 active site 114615005215 metal binding site [ion binding]; metal-binding site 114615005216 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_21; cd04680 114615005217 nudix motif; other site 114615005218 DPM_DPG-synthase_like is a member of the Glycosyltransferase 2 superfamily; Region: DPM_DPG-synthase_like; cd04179 114615005219 Ligand binding site [chemical binding]; other site 114615005220 Putative Catalytic site [active] 114615005221 DXD motif; other site 114615005222 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 114615005223 M20 Peptidase Aminoacylase 1 subfamily; Region: M20_Acy1_like1; cd05666 114615005224 metal binding site [ion binding]; metal-binding site 114615005225 putative dimer interface [polypeptide binding]; other site 114615005226 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 114615005227 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16...; Region: OM_channels; cl00284 114615005228 Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GAT_1; cl00020 114615005229 Aerotolerance regulator N-terminal; Region: BatA; cl06567 114615005230 A4 beta-galactosidase middle domain: a type 1 glutamine amidotransferase (GATase1)-like domain; Region: A4_beta-galactosidase_middle_domain; cd03143 114615005231 Uncharacterized conserved protein (some members contain a von Willebrand factor type A (vWA) domain) [General function prediction only]; Region: COG1721 114615005232 Protein of unknown function DUF58; Region: DUF58; pfam01882 114615005233 MoxR-like ATPases [General function prediction only]; Region: COG0714 114615005234 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 114615005235 Protein of unknown function (DUF1285); Region: DUF1285; cl01571 114615005236 Coenzyme A pyrophosphatase (CoAse), a member of the Nudix hydrolase superfamily, functions to catalyze the elimination of oxidized inactive CoA, which can inhibit CoA-utilizing enzymes. The need of CoAses mainly arises under conditions of oxidative...; Region: CoAse; cd03426 114615005237 putative active site [active] 114615005238 putative CoA binding site [chemical binding]; other site 114615005239 nudix motif; other site 114615005240 metal binding site [ion binding]; metal-binding site 114615005241 tRNA nucleotidyltransferase/poly(A) polymerase [Translation, ribosomal structure and biogenesis]; Region: PcnB; COG0617 114615005242 Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398 114615005243 active site 114615005244 NTP binding site [chemical binding]; other site 114615005245 metal binding triad [ion binding]; metal-binding site 114615005246 Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627 114615005247 Four helix bundle sensory module for signal transduction; Region: 4HB_MCP_2; pfam12729 114615005248 Signal transduction histidine kinase, nitrate/nitrite-specific [Signal transduction mechanisms]; Region: NarQ; COG3850 114615005249 Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices connected by an extended linker. The...; Region: HAMP; cl01054 114615005250 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 114615005251 metal binding site [ion binding]; metal-binding site 114615005252 active site 114615005253 I-site; other site 114615005254 Predicted hydrolase (HAD superfamily) [General function prediction only]; Region: COG1011 114615005255 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others...; Region: HAD_like; cd01427 114615005256 motif II; other site 114615005257 Coproporphyrinogen III oxidase; Region: Coprogen_oxidas; cl00433 114615005258 Tunnelling fold (T-fold). The five known T-folds are found in five different enzymes with different functions: dihydroneopterin-triphosphate epimerase (DHNTPE), dihydroneopterin aldolase (DHNA) , GTP cyclohydrolase I (GTPCH-1), 6-pyrovoyl...; Region: TFold; cl00263 114615005259 active site 114615005260 Organic radical activating enzymes [Posttranslational modification, protein turnover, chaperones]; Region: NrdG; COG0602 114615005261 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster...; Region: Radical_SAM; cl15259 114615005262 SpoU rRNA Methylase family; Region: SpoU_methylase; cl00362 114615005263 Ubiquitinol-cytochrome C reductase Fe-S subunit TAT signal; Region: UCR_Fe-S_N; pfam10399 114615005264 Iron-sulfur protein (ISP) component of the bc(1) complex family, Rieske domain; The Rieske domain is a [2Fe-2S] cluster binding domain involved in electron transfer. The bc(1) complex is a multisubunit enzyme found in many different organisms including...; Region: Rieske_cytochrome_bc1; cd03470 114615005265 [2Fe-2S] cluster binding site [ion binding]; other site 114615005266 Cytochrome b (N-terminus)/b6/petB: Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria...; Region: Cytochrome_b_N; cd00284 114615005267 cytochrome b; Provisional; Region: CYTB; MTH00156 114615005268 Qi binding site; other site 114615005269 intrachain domain interface; other site 114615005270 interchain domain interface [polypeptide binding]; other site 114615005271 heme bH binding site [chemical binding]; other site 114615005272 heme bL binding site [chemical binding]; other site 114615005273 Qo binding site; other site 114615005274 Cytochrome b(C-terminus)/b6/petD: Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria...; Region: cytochrome_b_C; cd00290 114615005275 interchain domain interface [polypeptide binding]; other site 114615005276 intrachain domain interface; other site 114615005277 Qi binding site; other site 114615005278 Qo binding site; other site 114615005279 Cytochrome C1 family; Region: Cytochrom_C1; pfam02167 114615005280 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 114615005281 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 114615005282 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 114615005283 Dienelactone hydrolase and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG0412 114615005284 Domain of unknown function (DUF1835); Region: DUF1835; pfam08874 114615005285 Protein of unknown function; Region: DUF3658; pfam12395 114615005286 anthranilate synthase; Provisional; Region: PRK13566 114615005287 Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715 114615005288 chorismate binding enzyme; Region: Chorismate_bind; cl10555 114615005289 Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743 114615005290 glutamine binding [chemical binding]; other site 114615005291 catalytic triad [active] 114615005292 Phosphoribosyl transferase domain; Region: Pribosyltran; cl00309 114615005293 Peptidase family M48; Region: Peptidase_M48; cl12018 114615005294 LemA family; Region: LemA; cl00742 114615005295 Secreted repeat of unknown function; Region: Lipoprotein_15; pfam03640 114615005296 Secreted repeat of unknown function; Region: Lipoprotein_15; pfam03640 114615005297 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cl12011 114615005298 chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168 114615005299 Barmotin is a tight junction-associated protein expressed in rat epithelial cells which is thought to have an important regulatory role in tight junction barrier function. Barmotin belongs to the SMC protein family. SMC proteins are large (...; Region: ABC_SMC_barmotin; cd03278 114615005300 Walker A/P-loop; other site 114615005301 ATP binding site [chemical binding]; other site 114615005302 Q-loop/lid; other site 114615005303 SMC proteins Flexible Hinge Domain; Region: SMC_hinge; cl05797 114615005304 Barmotin is a tight junction-associated protein expressed in rat epithelial cells which is thought to have an important regulatory role in tight junction barrier function. Barmotin belongs to the SMC protein family. SMC proteins are large (...; Region: ABC_SMC_barmotin; cd03278 114615005305 ABC transporter signature motif; other site 114615005306 Walker B; other site 114615005307 D-loop; other site 114615005308 H-loop/switch region; other site 114615005309 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 114615005310 DSBA-like thioredoxin domain; Region: DSBA; pfam01323 114615005311 Protein of unknown function (DUF721); Region: DUF721; cl02324 114615005312 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 114615005313 non-specific DNA binding site [nucleotide binding]; other site 114615005314 salt bridge; other site 114615005315 sequence-specific DNA binding site [nucleotide binding]; other site 114615005316 A/G-specific DNA glycosylase [DNA replication, recombination, and repair]; Region: MutY; COG1194 114615005317 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 114615005318 minor groove reading motif; other site 114615005319 helix-hairpin-helix signature motif; other site 114615005320 substrate binding pocket [chemical binding]; other site 114615005321 active site 114615005322 Iron-sulfur binding domain of endonuclease III; Region: EndIII_4Fe-2S; cl15304 114615005323 DNA glycosylase (MutY in bacteria and hMYH in humans) is responsible for repairing misread A*oxoG residues to C*G by removing the inappropriately paired adenine base from the DNA backbone. It belongs to the Nudix hydrolase superfamily and is important...; Region: DNA_Glycosylase_C; cd03431 114615005324 DNA binding and oxoG recognition site [nucleotide binding] 114615005325 glutathionine S-transferase; Provisional; Region: PRK10542 114615005326 GST_N family, Class Beta subfamily; GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of endogenous and xenobiotic alkylating agents, including carcinogens...; Region: GST_N_Beta; cd03057 114615005327 C-terminal domain interface [polypeptide binding]; other site 114615005328 GSH binding site (G-site) [chemical binding]; other site 114615005329 dimer interface [polypeptide binding]; other site 114615005330 C-terminal, alpha helical domain of Class Beta Glutathione S-transferases; Region: GST_C_Beta; cd03188 114615005331 dimer interface [polypeptide binding]; other site 114615005332 N-terminal domain interface [polypeptide binding]; other site 114615005333 substrate binding pocket (H-site) [chemical binding]; other site 114615005334 Heme oxygenase catalyzes the rate limiting step in the degradation of heme to bilirubin, it is essential for recycling of iron from heme. Heme is used as a substrate and cofactor for its own degradation to biliverdin, iron, and carbon monoxide. This...; Region: HemeO; cl15243 114615005335 Bacteriophytochrome (light-regulated signal transduction histidine kinase) [Signal transduction mechanisms]; Region: COG4251 114615005336 GAF domain; Region: GAF; cl00853 114615005337 Phytochrome region; Region: PHY; pfam00360 114615005338 Histidine kinase; Region: HisKA_2; cl06527 114615005339 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 114615005340 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156 114615005341 active site 114615005342 phosphorylation site [posttranslational modification] 114615005343 intermolecular recognition site; other site 114615005344 dimerization interface [polypeptide binding]; other site 114615005345 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cl12011 114615005346 Putative neutral zinc metallopeptidase; Region: Zn_peptidase; cl00988 114615005347 MogA_MoaB family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF) an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea...; Region: MogA_MoaB; cd00886 114615005348 MPT binding site; other site 114615005349 trimer interface [polypeptide binding]; other site 114615005350 Transcriptional regulators [Transcription]; Region: MarR; COG1846 114615005351 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 114615005352 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 114615005353 Coenzyme A binding pocket [chemical binding]; other site 114615005354 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 114615005355 active site 114615005356 putative phosphoketolase; Provisional; Region: PRK05261 114615005357 Thiamine pyrophosphate (TPP) family, Phosphoketolase (PK) subfamily, TPP-binding module; PK catalyzes the conversion of D-xylulose 5-phosphate and phosphate to acetyl phosphate, D-glyceraldehyde-3-phosphate and H2O. This enzyme requires divalent...; Region: TPP_PK; cd02011 114615005358 TPP-binding site; other site 114615005359 D-xylulose 5-phosphate/D-fructose 6-phosphate phosphoketolase; Region: XFP; pfam03894 114615005360 XFP C-terminal domain; Region: XFP_C; pfam09363 114615005361 DNA repair photolyase [DNA replication, recombination, and repair]; Region: SplB; COG1533 114615005362 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster...; Region: Radical_SAM; cd01335 114615005363 FeS/SAM binding site; other site 114615005364 bacterial Ribonuclease HII-like; Region: RNase_HII_bacteria_HII_like; cd07182 114615005365 RNA/DNA hybrid binding site [nucleotide binding]; other site 114615005366 active site 114615005367 4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family [Cell envelope biogenesis, outer membrane]; Region: ArnT; COG1807 114615005368 Family 4 Uracil-DNA glycosylase (UDG), found exclusively in thermophilic organisms; Region: UDG_F4_TTUDGA_like; cd10030 114615005369 Fe-S cluster binding site [ion binding]; other site 114615005370 active site 114615005371 Dehydrogenases (flavoproteins) [Energy production and conversion]; Region: FixC; COG0644 114615005372 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 114615005373 Electron transfer flavoprotein-ubiquinone oxidoreductase; Region: ETF_QO; pfam05187 114615005374 Ferredoxin-like protein [Energy production and conversion]; Region: FixX; COG2440 114615005375 putative PEP-CTERM system TPR-repeat lipoprotein; Region: PEP_TPR_lipo; TIGR02917 114615005376 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi...; Region: TPR; cd00189 114615005377 binding surface 114615005378 TPR motif; other site 114615005379 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi...; Region: TPR; cd00189 114615005380 binding surface 114615005381 TPR motif; other site 114615005382 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase; Provisional; Region: PRK14608 114615005383 octaprenyl diphosphate synthase; Provisional; Region: PRK10888 114615005384 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 114615005385 substrate binding pocket [chemical binding]; other site 114615005386 chain length determination region; other site 114615005387 substrate-Mg2+ binding site; other site 114615005388 catalytic residues [active] 114615005389 aspartate-rich region 1; other site 114615005390 active site lid residues [active] 114615005391 aspartate-rich region 2; other site 114615005392 Protein of unknown function (DUF2007); Region: DUF2007; pfam09413 114615005393 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cl12011 114615005394 Signal peptide peptidase A (SppA), a serine protease, has catalytic Ser-Lys dyad; Region: S49_Sppa_N_C; cd07023 114615005395 tandem repeat interface [polypeptide binding]; other site 114615005396 oligomer interface [polypeptide binding]; other site 114615005397 active site residues [active] 114615005398 glycyl-tRNA synthetase, tetrameric type, alpha subunit; Region: glyQ; TIGR00388 114615005399 Class II Glycyl-tRNA synthetase (GlyRS) alpha subunit core catalytic domain. GlyRS functions as a homodimer in eukaryotes, archaea and some bacteria and as a heterotetramer in the remainder of prokaryotes and in arabidopsis. It is responsible for the...; Region: GlyRS_alpha_core; cd00733 114615005400 dimer interface [polypeptide binding]; other site 114615005401 motif 1; other site 114615005402 active site 114615005403 motif 2; other site 114615005404 motif 3; other site 114615005405 Iron-binding zinc finger CDGSH type; Region: zf-CDGSH; cl02748 114615005406 Iron-binding zinc finger CDGSH type; Region: zf-CDGSH; cl02748 114615005407 glycyl-tRNA synthetase subunit beta; Validated; Region: glyS; PRK01233 114615005408 Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020 114615005409 Protein of unknown function (DUF1236); Region: DUF1236; pfam06823 114615005410 pyruvate phosphate dikinase; Provisional; Region: PRK09279 114615005411 Pyruvate phosphate dikinase, PEP/pyruvate binding domain; Region: PPDK_N; pfam01326 114615005412 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; cl01586 114615005413 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl09155 114615005414 Cell Wall Hydrolase; Region: Hydrolase_2; pfam07486 114615005415 L-aspartate oxidase; Provisional; Region: PRK07512 114615005416 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 114615005417 domain; Region: Succ_DH_flav_C; pfam02910 114615005418 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 114615005419 Major Facilitator Superfamily; Region: MFS_1; pfam07690 114615005420 putative substrate translocation pore; other site 114615005421 Yhdh putative quinone oxidoreductases; Region: MDR_yhdh; cd08288 114615005422 putative quinone oxidoreductase, YhdH/YhfP family; Region: oxido_YhdH; TIGR02823 114615005423 NADP binding site [chemical binding]; other site 114615005424 dimer interface [polypeptide binding]; other site 114615005425 Four helix bundle sensory module for signal transduction; Region: 4HB_MCP_2; pfam12729 114615005426 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 114615005427 Taxis toward Aspartate and Related amino acids and Homologs (TarH). The Tar chemoreceptor of Escherichia coli mediates attractant responses to aspartate, maltose, and phenol, repellent responses to Ni2+ and Co2+, and thermoresponses. These...; Region: TarH; cl00144 114615005428 Four helix bundle sensory module for signal transduction; Region: 4HB_MCP_2; pfam12729 114615005429 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 114615005430 Taxis toward Aspartate and Related amino acids and Homologs (TarH). The Tar chemoreceptor of Escherichia coli mediates attractant responses to aspartate, maltose, and phenol, repellent responses to Ni2+ and Co2+, and thermoresponses. These...; Region: TarH; cl00144 114615005431 Predicted membrane protein (DUF2339); Region: DUF2339; pfam10101 114615005432 Predicted membrane protein (DUF2339); Region: DUF2339; pfam10101 114615005433 Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr (; Region: PTPc; cl00053 114615005434 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cl00076 114615005435 Methyladenine glycosylase; Region: Adenine_glyco; cl01059 114615005436 Predicted aminomethyltransferase related to GcvT [General function prediction only]; Region: COG0354 114615005437 folate-binding protein YgfZ; Region: ygfZ_signature; TIGR03317 114615005438 Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669 114615005439 dihydroorotase; Validated; Region: PRK09060 114615005440 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have...; Region: metallo-dependent_hydrolases; cl00281 114615005441 Dihydroorotase (DHOase), subgroup IIb; DHOases catalyze the reversible interconversion of carbamoyl aspartate to dihydroorotate, a key reaction in pyrimidine biosynthesis. This group contains the archeal members of the DHOase family; Region: DHOase_IIb; cd01318 114615005442 active site 114615005443 Chemotaxis phosphatase, CheZ; Region: CheZ; cl01219 114615005444 Protein of unknown function (DUF2385); Region: DUF2385; cl11490 114615005445 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_15; cd04673 114615005446 nudix motif; other site 114615005447 Uncharacterised ACR, COG2135; Region: DUF159; cl03646 114615005448 GDP-mannose pyrophosphatase NudK; Provisional; Region: PRK15009 114615005449 ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as...; Region: ADPRase_NUDT5; cd03424 114615005450 dimer interface [polypeptide binding]; other site 114615005451 ADP-ribose binding site [chemical binding]; other site 114615005452 active site 114615005453 nudix motif; other site 114615005454 metal binding site [ion binding]; metal-binding site 114615005455 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 114615005456 Coenzyme A binding pocket [chemical binding]; other site 114615005457 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 114615005458 FAD binding domain; Region: FAD_binding_4; pfam01565 114615005459 yrdC domain; Region: Sua5_yciO_yrdC; cl00305 114615005460 SUA5 domain; Region: SUA5; pfam03481 114615005461 hypothetical protein; Provisional; Region: PRK06126 114615005462 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 114615005463 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 114615005464 Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices connected by an extended linker. The...; Region: HAMP; cl01054 114615005465 Taxis toward Aspartate and Related amino acids and Homologs (TarH). The Tar chemoreceptor of Escherichia coli mediates attractant responses to aspartate, maltose, and phenol, repellent responses to Ni2+ and Co2+, and thermoresponses. These...; Region: TarH; cl00144 114615005466 Predicted outer membrane protein [Function unknown]; Region: COG3652 114615005467 UDP-glucuronate decarboxylase (UGD) and related proteins, extended (e) SDRs; Region: UGD_SDR_e; cd05230 114615005468 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 114615005469 NAD binding site [chemical binding]; other site 114615005470 putative substrate binding site 2 [chemical binding]; other site 114615005471 putative substrate binding site 1 [chemical binding]; other site 114615005472 active site 114615005473 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 114615005474 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 114615005475 Glycosyl transferases group 1; Region: Glycos_transf_1; cl12012 114615005476 Glycosyl transferases group 1; Region: Glycos_transf_1; cl12012 114615005477 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 114615005478 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 114615005479 B12 binding domain (B12-BD). Most of the members bind different cobalamid derivates, like B12 (adenosylcobamide) or methylcobalamin or methyl-Co(III) 5-hydroxybenzimidazolylcobamide. This domain is found in several enzymes, such as glutamate mutase...; Region: B12-binding_like; cl00293 114615005480 Radical SAM; Region: Elp3; smart00729 114615005481 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster...; Region: Radical_SAM; cl15259 114615005482 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 114615005483 dTDP-D-glucose 4,6-dehydratase [Cell envelope biogenesis, outer membrane]; Region: RfbB; COG1088 114615005484 NAD(P) binding site [chemical binding]; other site 114615005485 active site 114615005486 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 114615005487 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 114615005488 NAD(P) binding site [chemical binding]; other site 114615005489 active site 114615005490 Sulfatase; Region: Sulfatase; cl10460 114615005491 Metalloenzyme superfamily; Region: Metalloenzyme; pfam01676 114615005492 Glycosyl hydrolases family 39; Region: Glyco_hydro_39; cl10042 114615005493 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cl12011 114615005494 NTP_transferases catalyze the transfer of nucleotides onto phosphosugars; Region: NTP_transferase; cd04181 114615005495 active site 114615005496 Substrate binding site [chemical binding]; other site 114615005497 Mg++ binding site [ion binding]; other site 114615005498 Glycosyl transferases group 1; Region: Glycos_transf_1; cl12012 114615005499 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 114615005500 catalytic core [active] 114615005501 Myo-inositol-1-phosphate synthase; Region: Inos-1-P_synth; cl00554 114615005502 Myo-inositol-1-phosphate synthase; Region: NAD_binding_5; pfam07994 114615005503 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 114615005504 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 114615005505 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cl00047 114615005506 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 114615005507 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 114615005508 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 114615005509 Protein of unknown function (DUF3551); Region: DUF3551; pfam12071 114615005510 Ribonuclease BN-like family; Region: Ribonuclease_BN; cl07918 114615005511 circadian clock protein KaiC; Reviewed; Region: PRK09302 114615005512 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 114615005513 Walker A motif; other site 114615005514 ATP binding site [chemical binding]; other site 114615005515 Walker B motif; other site 114615005516 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 114615005517 Walker A motif; other site 114615005518 ATP binding site [chemical binding]; other site 114615005519 Walker B motif; other site 114615005520 Predicted signal transduction protein with a C-terminal ATPase domain [Signal transduction mechanisms]; Region: COG2972 114615005521 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via trans-...; Region: HisKA; cd00082 114615005522 dimer interface [polypeptide binding]; other site 114615005523 phosphorylation site [posttranslational modification] 114615005524 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 114615005525 ATP binding site [chemical binding]; other site 114615005526 G-X-G motif; other site 114615005527 Response regulator receiver domain; Region: Response_reg; pfam00072 114615005528 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156 114615005529 active site 114615005530 phosphorylation site [posttranslational modification] 114615005531 intermolecular recognition site; other site 114615005532 dimerization interface [polypeptide binding]; other site 114615005533 amidase; Provisional; Region: PRK07487 114615005534 GGCT-like domains, also called AIG2-like family. Gamma-glutamyl cyclotransferase (GGCT) catalyzes the formation of pyroglutamic acid (5-oxoproline) from dipeptides containing gamma-glutamyl, and is a dimeric protein. In Homo sapiens, the protein is...; Region: GGCT_like; cl11426 114615005535 PAS fold; Region: PAS_4; pfam08448 114615005536 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 114615005537 putative active site [active] 114615005538 heme pocket [chemical binding]; other site 114615005539 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 114615005540 PAS fold; Region: PAS_3; pfam08447 114615005541 putative active site [active] 114615005542 heme pocket [chemical binding]; other site 114615005543 PAS fold; Region: PAS_3; pfam08447 114615005544 Motif C-terminal to PAS motifs (likely to contribute to PAS structural domain); Region: PAC; smart00086 114615005545 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via trans-...; Region: HisKA; cd00082 114615005546 dimer interface [polypeptide binding]; other site 114615005547 phosphorylation site [posttranslational modification] 114615005548 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 114615005549 ATP binding site [chemical binding]; other site 114615005550 Mg2+ binding site [ion binding]; other site 114615005551 G-X-G motif; other site 114615005552 DoxX; Region: DoxX; cl00976 114615005553 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 114615005554 Serine acetyltransferase, N-terminal; Region: SATase_N; cl05762 114615005555 serine O-acetyltransferase; Region: cysE; TIGR01172 114615005556 Serine acetyltransferase (SAT): SAT catalyzes the CoA-dependent acetylation of the side chain hydroxyl group of L-serine to form O-acetylserine, as the first step of a two-step biosynthetic pathway in bacteria and plants leading to the formation of L-...; Region: LbH_SAT; cd03354 114615005557 trimer interface [polypeptide binding]; other site 114615005558 active site 114615005559 substrate binding site [chemical binding]; other site 114615005560 CoA binding site [chemical binding]; other site 114615005561 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_24; cd04683 114615005562 nudix motif; other site 114615005563 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 114615005564 classical (c) SDRs; Region: SDR_c; cd05233 114615005565 NAD(P) binding site [chemical binding]; other site 114615005566 active site 114615005567 NAD+-dependent alpha-aminoadipic semialdehyde dehydrogenase, ALDH family members 7A1 and 7B; Region: ALDH_F7_AASADH; cd07130 114615005568 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 114615005569 tetrameric interface [polypeptide binding]; other site 114615005570 NAD binding site [chemical binding]; other site 114615005571 catalytic residues [active] 114615005572 Protein of unknown function (DUF3606); Region: DUF3606; pfam12244 114615005573 Nicotinamidase/pyrazinamidase (PZase). Nicotinamidase, a ubiquitous enzyme in prokaryotes, converts nicotinamide to nicotinic acid (niacin) and ammonia, which in turn can be recycled to make nicotinamide adenine dinucleotide (NAD). The same enzyme is...; Region: nicotinamidase; cd01011 114615005574 catalytic triad [active] 114615005575 metal binding site [ion binding]; metal-binding site 114615005576 conserved cis-peptide bond; other site 114615005577 Hydantoinase/oxoprolinase N-terminal region; Region: Hydant_A_N; pfam05378 114615005578 Hydantoinase/oxoprolinase; Region: Hydantoinase_A; cl00668 114615005579 Uncharacterized conserved protein [Function unknown]; Region: COG3535 114615005580 Protein of unknown function (DUF917); Region: DUF917; pfam06032 114615005581 putrescine/spermidine ABC transporter ATPase protein; Reviewed; Region: potA; PRK09452 114615005582 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 114615005583 Walker A/P-loop; other site 114615005584 ATP binding site [chemical binding]; other site 114615005585 Q-loop/lid; other site 114615005586 ABC transporter signature motif; other site 114615005587 Walker B; other site 114615005588 D-loop; other site 114615005589 H-loop/switch region; other site 114615005590 TOBE domain; Region: TOBE_2; cl01440 114615005591 Spermidine/putrescine-binding periplasmic protein [Amino acid transport and metabolism]; Region: PotD; COG0687 114615005592 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 114615005593 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261 114615005594 dimer interface [polypeptide binding]; other site 114615005595 conserved gate region; other site 114615005596 putative PBP binding loops; other site 114615005597 ABC-ATPase subunit interface; other site 114615005598 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261 114615005599 dimer interface [polypeptide binding]; other site 114615005600 conserved gate region; other site 114615005601 putative PBP binding loops; other site 114615005602 ABC-ATPase subunit interface; other site 114615005603 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 114615005604 Transcriptional regulator [Transcription]; Region: IclR; COG1414 114615005605 Bacterial transcriptional regulator; Region: IclR; pfam01614 114615005606 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 114615005607 Aerobic-type carbon monoxide dehydrogenase, large subunit CoxL/CutL homologs [Energy production and conversion]; Region: CoxL; COG1529 114615005608 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; cl03161 114615005609 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 114615005610 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 114615005611 Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010 114615005612 Cytochrome c; Region: Cytochrom_C; cl11414 114615005613 Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010 114615005614 Cytochrome c; Region: Cytochrom_C; cl11414 114615005615 Aerobic-type carbon monoxide dehydrogenase, small subunit CoxS/CutS homologs [Energy production and conversion]; Region: CoxS; COG2080 114615005616 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cl00159 114615005617 [2Fe-2S] binding domain; Region: Fer2_2; pfam01799 114615005618 ApbE family; Region: ApbE; cl00643 114615005619 Protein of unknown function (DUF1185); Region: DUF1185; pfam06684 114615005620 ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683 114615005621 Periplasmic solute-binding domain of active transport proteins; Region: PBP1_Arsenic_SBP_like; cd06330 114615005622 putative ligand binding site [chemical binding]; other site 114615005623 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 114615005624 TM-ABC transporter signature motif; other site 114615005625 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 114615005626 TM-ABC transporter signature motif; other site 114615005627 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411 114615005628 The Mj1267/LivG ABC transporter subfamily is involved in the transport of the hydrophobic amino acids leucine, isoleucine and valine. MJ1267 is a branched-chain amino acid transporter with 29% similarity to both the LivF and LivG components of the E...; Region: ABC_Mj1267_LivG_branched; cd03219 114615005629 Walker A/P-loop; other site 114615005630 ATP binding site [chemical binding]; other site 114615005631 Q-loop/lid; other site 114615005632 ABC transporter signature motif; other site 114615005633 Walker B; other site 114615005634 D-loop; other site 114615005635 H-loop/switch region; other site 114615005636 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410 114615005637 LivF (TM1139) is part of the LIV-I bacterial ABC-type two-component transport system that imports neutral, branched-chain amino acids. The E. coli branched-chain amino acid transporter comprises a heterodimer of ABC transporters (LivF and LivG), a...; Region: ABC_TM1139_LivF_branched; cd03224 114615005638 Walker A/P-loop; other site 114615005639 ATP binding site [chemical binding]; other site 114615005640 Q-loop/lid; other site 114615005641 ABC transporter signature motif; other site 114615005642 Walker B; other site 114615005643 D-loop; other site 114615005644 H-loop/switch region; other site 114615005645 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 114615005646 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have...; Region: metallo-dependent_hydrolases; cl00281 114615005647 Imidazolonepropionase and related amidohydrolases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: HutI; COG1228 114615005648 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have...; Region: metallo-dependent_hydrolases; cd01292 114615005649 active site 114615005650 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have...; Region: metallo-dependent_hydrolases; cl00281 114615005651 Galactose mutarotase and related enzymes [Carbohydrate transport and metabolism]; Region: GalM; COG2017 114615005652 Aldose 1-epimerase, similar to Lactococcus lactis lacX; Region: Aldose_epim_lacX; cd09024 114615005653 active site 114615005654 catalytic residues [active] 114615005655 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and...; Region: Aldo_ket_red; cd06660 114615005656 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 114615005657 active site 114615005658 catalytic tetrad [active] 114615005659 dihydroorotase; Provisional; Region: PRK09237 114615005660 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have...; Region: metallo-dependent_hydrolases; cl00281 114615005661 active site 114615005662 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 114615005663 pyridoxal 5'-phosphate binding site [chemical binding]; other site 114615005664 homodimer interface [polypeptide binding]; other site 114615005665 catalytic residue [active] 114615005666 bifunctional 3,4-dihydroxy-2-butanone 4-phosphate synthase/GTP cyclohydrolase II protein; Provisional; Region: PRK09311 114615005667 3,4-dihydroxy-2-butanone 4-phosphate synthase; Region: DHBP_synthase; cl00336 114615005668 GTP cyclohydrolase II (RibA). GTP cyclohydrolase II catalyzes the conversion of GTP to 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5' phosphate, formate, pyrophosphate (APy), and GMP in the biosynthetic pathway of riboflavin. Riboflavin is the...; Region: GTP_cyclohydro2; cl00522 114615005669 dimerization interface [polypeptide binding]; other site 114615005670 active site 114615005671 Glutaryl-CoA dehydrogenase; Region: GCD; cd01151 114615005672 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 114615005673 FAD binding site [chemical binding]; other site 114615005674 substrate binding pocket [chemical binding]; other site 114615005675 catalytic base [active] 114615005676 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 114615005677 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 114615005678 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 114615005679 active site 114615005680 metal binding site [ion binding]; metal-binding site 114615005681 Protein of unknown function (DUF1499); Region: DUF1499; cl01841 114615005682 ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683 114615005683 Periplasmic solute-binding domain of active transport proteins that belong to the type I periplasmic binding fold protein family; Region: PBP1_SBP_like_1; cd06327 114615005684 putative ligand binding site [chemical binding]; other site 114615005685 putative acyl-CoA synthetase; Provisional; Region: PRK06018 114615005686 Acyl-protein synthetase, LuxE; Region: LuxE; cl10450 114615005687 Extensin-like protein C-terminus; Region: Extensin-like_C; pfam06904 114615005688 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 114615005689 Mg2+ and Co2+ transporters [Inorganic ion transport and metabolism]; Region: CorA; COG0598 114615005690 magnesium/nickel/cobalt transporter CorA; Provisional; Region: PRK11085; cl00459 114615005691 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 114615005692 classical (c) SDRs; Region: SDR_c; cd05233 114615005693 NAD(P) binding site [chemical binding]; other site 114615005694 active site 114615005695 pyridoxamine 5'-phosphate oxidase; Provisional; Region: PRK05679 114615005696 Pyridoxine 5'-phosphate (PNP) oxidase-like proteins; Region: PNPOx_like; cl00381 114615005697 Pyridoxine 5'-phosphate oxidase C-terminal dimerisation region; Region: PNPOx_C; pfam10590 114615005698 curved DNA-binding protein CbpA; Provisional; Region: PRK10266 114615005699 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of...; Region: DnaJ; cd06257 114615005700 HSP70 interaction site [polypeptide binding]; other site 114615005701 DnaJ C terminal domain; Region: DnaJ_C; pfam01556 114615005702 DnaJ C terminal domain; Region: DnaJ_C; pfam01556 114615005703 Predicted transmembrane transcriptional regulator (anti-sigma factor) [Transcription]; Region: COG5662 114615005704 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 114615005705 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial...; Region: Sigma70_r4; cd06171 114615005706 DNA binding residues [nucleotide binding] 114615005707 enoyl-(acyl carrier protein) reductase; Provisional; Region: PRK08159 114615005708 Enoyl acyl carrier protein (ACP) reductase (ENR), divergent SDR; Region: ENR_SDR; cd05372 114615005709 NAD binding site [chemical binding]; other site 114615005710 homotetramer interface [polypeptide binding]; other site 114615005711 homodimer interface [polypeptide binding]; other site 114615005712 substrate binding site [chemical binding]; other site 114615005713 active site 114615005714 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 114615005715 Histidine phosphatase superfamily (branch 1); Region: His_Phos_1; pfam00300 114615005716 catalytic core [active] 114615005717 Chorismase synthase, the enzyme catalyzing the final step of the shikimate pathway; Region: Chorismate_synthase; cd07304 114615005718 Tetramer interface [polypeptide binding]; other site 114615005719 Active site [active] 114615005720 FMN-binding site [chemical binding]; other site 114615005721 cyclase homology domain; Region: CHD; cd07302 114615005722 nucleotidyl binding site; other site 114615005723 metal binding site [ion binding]; metal-binding site 114615005724 dimer interface [polypeptide binding]; other site 114615005725 ATP-dependent Clp protease adaptor protein ClpS; Region: ClpS; cl00933 114615005726 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198 114615005727 metal ion-dependent adhesion site (MIDAS); other site 114615005728 Rare lipoprotein A (RlpA)-like double-psi beta-barrel; Region: DPBB_1; cl04011 114615005729 SAM-dependent methyltransferases related to tRNA (uracil-5-)-methyltransferase [Translation, ribosomal structure and biogenesis]; Region: TrmA; COG2265 114615005730 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cl12011 114615005731 Predicted rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: COG1189 114615005732 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cl09940 114615005733 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cl12011 114615005734 Nucleoside 2-deoxyribosyltransferase; Region: Nuc_deoxyrib_tr; cl01450 114615005735 1-deoxy-D-xylulose-5-phosphate synthase; Provisional; Region: PRK05444 114615005736 TPP-binding module; 1-Deoxy-D-xylulose-5-phosphate synthase (DXS) is a regulatory enzyme of the mevalonate-independent pathway involved in terpenoid biosynthesis. Terpeniods are plant natural products with important pharmaceutical activity. DXS...; Region: TPP_DXS; cd02007 114615005737 TPP-binding site; other site 114615005738 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 114615005739 PYR/PP interface [polypeptide binding]; other site 114615005740 dimer interface [polypeptide binding]; other site 114615005741 TPP binding site [chemical binding]; other site 114615005742 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 114615005743 Exonuclease VII small subunit; Region: Exonuc_VII_S; cl00750 114615005744 Deacetylases, including yeast histone deacetylase and acetoin utilization protein [Chromatin structure and dynamics / Secondary metabolites biosynthesis, transport, and catabolism]; Region: AcuC; COG0123 114615005745 Histone deacetylase domain; Region: Hist_deacetyl; cl02986 114615005746 5'-nucleotidase/2',3'-cyclic phosphodiesterase and related esterases [Nucleotide transport and metabolism]; Region: UshA; COG0737 114615005747 Bacillus subtilis YhcR endonuclease and related proteins, N-terminal metallophosphatase domain; Region: MPP_YhcR_N; cd07412 114615005748 putative active site [active] 114615005749 putative metal binding site [ion binding]; other site 114615005750 5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872 114615005751 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 114615005752 Malate:quinone oxidoreductase (Mqo); Region: Mqo; cl14881 114615005753 sarcosine oxidase, monomeric form; Region: soxA_mon; TIGR01377 114615005754 enoyl-CoA hydratase; Provisional; Region: PRK06023 114615005755 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase...; Region: crotonase-like; cd06558 114615005756 substrate binding site [chemical binding]; other site 114615005757 oxyanion hole (OAH) forming residues; other site 114615005758 trimer interface [polypeptide binding]; other site 114615005759 Manganese catalase, ferritin-like diiron-binding domain; Region: Mn_catalase; cd01051 114615005760 dimanganese center [ion binding]; other site 114615005761 YciF bacterial stress response protein, ferritin-like iron-binding domain; Region: YciF; cd07909 114615005762 dimerization interface [polypeptide binding]; other site 114615005763 metal binding site [ion binding]; metal-binding site 114615005764 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 114615005765 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 114615005766 active site 114615005767 Acetyl-CoA dehydrogenase C-terminal like; Region: Acyl-CoA_dh_C; pfam12806 114615005768 TIR domain; Region: TIR; cl02060 114615005769 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues...; Region: WD40; cl02567 114615005770 Cellulase (glycosyl hydrolase family 5); Region: Cellulase; cl14895 114615005771 GDP-fucose synthetase, extended (e) SDRs; Region: GDP_FS_SDR_e; cd05239 114615005772 GDP-4-keto-6-deoxymannose-3, 5-epimerase-4-reductase; Region: PLN02725 114615005773 NADP binding site [chemical binding]; other site 114615005774 active site 114615005775 putative substrate binding site [chemical binding]; other site 114615005776 GDP-mannose 4,6-dehydratase; Region: gmd; TIGR01472 114615005777 GDP-mannose 4,6 dehydratase, extended (e) SDRs; Region: GDP_MD_SDR_e; cd05260 114615005778 NADP-binding site; other site 114615005779 homotetramer interface [polypeptide binding]; other site 114615005780 substrate binding site [chemical binding]; other site 114615005781 homodimer interface [polypeptide binding]; other site 114615005782 active site 114615005783 Transglutaminase-like superfamily; Region: Transglut_core; cl10469 114615005784 FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790 114615005785 Sel1 repeat; Region: Sel1; cl02723 114615005786 general secretion pathway protein D; Region: type_II_gspD; TIGR02517 114615005787 Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958 114615005788 Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958 114615005789 Bacterial type II and III secretion system protein; Region: Secretin; cl02829 114615005790 Type II secretory pathway, component PulJ [Intracellular trafficking and secretion]; Region: PulJ; COG4795 114615005791 General secretion pathway protein K; Region: GspK; pfam03934 114615005792 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cl12011 114615005793 putative glycosyl transferase; Provisional; Region: PRK10307 114615005794 This family is most closely related to the GT1 family of glycosyltransferases. wbuB in E. coli is involved in the biosynthesis of the O26 O-antigen. It has been proposed to function as an N-acetyl-L-fucosamine (L-FucNAc) transferase; Region: GT1_wbuB_like; cd03794 114615005795 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and...; Region: Aldo_ket_red; cd06660 114615005796 active site 114615005797 catalytic tetrad [active] 114615005798 Choline dehydrogenase and related flavoproteins [Amino acid transport and metabolism]; Region: BetA; COG2303 114615005799 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 114615005800 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 114615005801 MBOAT family; Region: MBOAT; cl00738 114615005802 tocopherol O-methyltransferase; Region: PLN02244 114615005803 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cd02440 114615005804 S-adenosylmethionine binding site [chemical binding]; other site 114615005805 Predicted carbamoyl transferase, NodU family [Posttranslational modification, protein turnover, chaperones]; Region: COG2192 114615005806 Carbamoyltransferase; Region: CmcH_NodU; pfam02543 114615005807 Pectate lyase superfamily protein; Region: Pectate_lyase_3; pfam12708 114615005808 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 114615005809 UDP-glucose LOS-beta-1,4 glucosyltransferase is required for biosynthesis of lipooligosaccharide; Region: Beta4Glucosyltransferase; cd02511 114615005810 putative metal binding site [ion binding]; other site 114615005811 peptidylprolyl isomerase; Provisional; Region: prsA; PRK00059 114615005812 PPIC-type PPIASE domain; Region: Rotamase; cl08278 114615005813 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 114615005814 haemagglutination activity domain; Region: Haemagg_act; cl05436 114615005815 Filamentous haemagglutinin family outer membrane protein; Region: DUF3739; pfam12545 114615005816 Periplasmic protein involved in polysaccharide export, contains SLBB domain of b-grasp fold [Cell wall/membrane/envelope biogenesis]; Region: Wza; COG1596 114615005817 Polysaccharide biosynthesis/export protein; Region: Poly_export; pfam02563 114615005818 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 114615005819 This family is most closely related to the GT1 family of glycosyltransferases. Bme6 in Brucella melitensis has been shown to be involved in the biosynthesis of a polysaccharide; Region: GT1_Bme6_like; cd03821 114615005820 putative ADP-binding pocket [chemical binding]; other site 114615005821 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic 'goose-type' lysozymes (GEWL). LTs catalyze...; Region: LT_GEWL; cd00254 114615005822 N-acetyl-D-glucosamine binding site [chemical binding]; other site 114615005823 catalytic residue [active] 114615005824 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 114615005825 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 114615005826 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl15258 114615005827 Hemolysin activation/secretion protein [Intracellular trafficking and secretion]; Region: FhaC; COG2831 114615005828 Surface antigen variable number repeat; Region: Surf_Ag_VNR; cl10520 114615005829 Surface antigen; Region: Bac_surface_Ag; cl03097 114615005830 Domain of unknown function (DUF2341); Region: DUF2341; pfam10102 114615005831 Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of...; Region: LamG; cl00102 114615005832 MotA/TolQ/ExbB proton channel family; Region: MotA_ExbB; cl00568 114615005833 Biopolymer transport proteins [Intracellular trafficking and secretion]; Region: TolQ; COG0811 114615005834 Biopolymer transport protein ExbD/TolR; Region: ExbD; cl00537 114615005835 Protein of unknown function (DUF3450); Region: DUF3450; pfam11932 114615005836 peptidyl-prolyl cis-trans isomerase, EpsD family; Region: cis_trans_EpsD; TIGR02925 114615005837 periplasmic folding chaperone; Provisional; Region: PRK10788 114615005838 PPIC-type PPIASE domain; Region: Rotamase; cl08278 114615005839 Undecaprenyl-phosphate glucose phosphotransferase; Region: WcaJ_sugtrans; TIGR03023 114615005840 Bacterial sugar transferase; Region: Bac_transf; cl00939 114615005841 exopolysaccharide transport protein family; Region: eps_transp_fam; TIGR01005 114615005842 Chain length determinant protein; Region: Wzz; cl01623 114615005843 ArsA ATPase functionas as an efflux pump located on the inner membrane of the cell. This ATP-driven oxyanion pump catalyzes the extrusion of arsenite, antimonite and arsenate. Maintenance of a low intracellular concentration of oxyanion produces...; Region: ArsA; cd02035 114615005844 Nucleotide binding site [chemical binding]; other site 114615005845 DTAP/Switch II; other site 114615005846 Switch I; other site 114615005847 Predicted carbamoyl transferase, NodU family [Posttranslational modification, protein turnover, chaperones]; Region: COG2192 114615005848 Carbamoyltransferase; Region: CmcH_NodU; pfam02543 114615005849 SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cd00229 114615005850 active site 114615005851 oxyanion hole [active] 114615005852 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 114615005853 Acetolactate synthase [Amino acid transport and metabolism]; Region: COG3962 114615005854 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 114615005855 TPP binding site [chemical binding]; other site 114615005856 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 114615005857 TPP-binding module; composed of proteins similar to Rhizobium leguminosarum bv. viciae IolD. IolD plays an important role in myo-inositol catabolism; Region: TPP_IolD; cd02003 114615005858 TPP-binding site; other site 114615005859 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 114615005860 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 114615005861 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; cl11611 114615005862 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 114615005863 FAD binding domain; Region: FAD_binding_4; pfam01565 114615005864 Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247 114615005865 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 114615005866 Multidrug resistance efflux pump [Defense mechanisms]; Region: EmrA; COG1566 114615005867 ABC-2 family transporter protein; Region: ABC2_membrane_3; pfam12698 114615005868 ABC-2 family transporter protein; Region: ABC2_membrane_3; pfam12698 114615005869 YhgE/Pip N-terminal domain; Region: pip_yhgE_Nterm; TIGR03061 114615005870 ABC-2 family transporter protein; Region: ABC2_membrane_3; pfam12698 114615005871 efflux pump membrane protein (multidrug resistance protein A); Region: 8a0101; TIGR00998 114615005872 Arabinose-binding domain of AraC transcription regulator, N-term; Region: Arabinose_bd; pfam12625 114615005873 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 114615005874 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 114615005875 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 114615005876 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 114615005877 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 114615005878 Peptidase propeptide and YPEB domain; Region: PepSY; pfam03413 114615005879 Cytochrome c; Region: Cytochrom_C; cl11414 114615005880 Cytochrome c; Region: Cytochrom_C; cl11414 114615005881 Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010 114615005882 Cytochrome c; Region: Cytochrom_C; cl11414 114615005883 Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; cl11412 114615005884 ba3-like heme-copper oxidase subunit I. The ba3 family of heme-copper oxidases are transmembrane protein complexes in the respiratory chains of prokaryotes and some archaea which catalyze the reduction of O2 and simultaneously pump protons across the...; Region: ba3-like_Oxidase_I; cd01660 114615005885 Putative D-pathway homolog; other site 114615005886 Low-spin heme binding site [chemical binding]; other site 114615005887 Subunit I/II interface [polypeptide binding]; other site 114615005888 Putative Q-pathway; other site 114615005889 Putative alternate electron transfer pathway; other site 114615005890 Putative water exit pathway; other site 114615005891 Binuclear center (active site) [active] 114615005892 Putative K-pathway homolog; other site 114615005893 Putative proton exit pathway; other site 114615005894 Subunit I/IIa interface [polypeptide binding]; other site 114615005895 Electron transfer pathway; other site 114615005896 Cytochrome c; Region: Cytochrom_C; cl11414 114615005897 Cytochrome c; Region: Cytochrom_C; cl11414 114615005898 Transcriptional regulator [Transcription]; Region: LysR; COG0583 114615005899 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 114615005900 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 114615005901 dimerization interface [polypeptide binding]; other site 114615005902 Intradiol dioxygenases catalyze the critical ring-cleavage step in the conversion of catecholate derivatives to citric acid cycle intermediates. This family contains catechol 1,2-dioxygenases and protocatechuate 3,4-dioxygenases which are mononuclear...; Region: intradiol_dioxygenase; cl01383 114615005903 chlorocatechol 1,2-dioxygenase; Region: chlorocat_1_2; TIGR02465 114615005904 Active site [active] 114615005905 Maleylacetate reductase is involved in many aromatic compounds degradation pathways of aerobic microbes; Region: MAR; cd08177 114615005906 Alcohol dehydrogenase, class IV [Energy production and conversion]; Region: EutG; COG1454 114615005907 active site 114615005908 dimer interface [polypeptide binding]; other site 114615005909 metal binding site [ion binding]; metal-binding site 114615005910 Type I periplasmic ligand-binding domain of uncharacterized ABC (ATPase Binding Cassette)-type active transport systems that are predicted to be involved in transport of amino acids, peptides, or inorganic ions; Region: PBP1_ABC_ligand_binding_like_4; cd06337 114615005911 putative ligand binding site [chemical binding]; other site 114615005912 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411 114615005913 The Mj1267/LivG ABC transporter subfamily is involved in the transport of the hydrophobic amino acids leucine, isoleucine and valine. MJ1267 is a branched-chain amino acid transporter with 29% similarity to both the LivF and LivG components of the E...; Region: ABC_Mj1267_LivG_branched; cd03219 114615005914 Walker A/P-loop; other site 114615005915 ATP binding site [chemical binding]; other site 114615005916 Q-loop/lid; other site 114615005917 ABC transporter signature motif; other site 114615005918 Walker B; other site 114615005919 D-loop; other site 114615005920 H-loop/switch region; other site 114615005921 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410 114615005922 LivF (TM1139) is part of the LIV-I bacterial ABC-type two-component transport system that imports neutral, branched-chain amino acids. The E. coli branched-chain amino acid transporter comprises a heterodimer of ABC transporters (LivF and LivG), a...; Region: ABC_TM1139_LivF_branched; cd03224 114615005923 Walker A/P-loop; other site 114615005924 ATP binding site [chemical binding]; other site 114615005925 Q-loop/lid; other site 114615005926 ABC transporter signature motif; other site 114615005927 Walker B; other site 114615005928 D-loop; other site 114615005929 H-loop/switch region; other site 114615005930 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 114615005931 TM-ABC transporter signature motif; other site 114615005932 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 114615005933 TM-ABC transporter signature motif; other site 114615005934 FAD binding domain; Region: FAD_binding_3; pfam01494 114615005935 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 114615005936 Hydroxyquinol 1,2-dioxygenase (1,2-HQD) catalyzes the ring cleavage of hydroxyquinol (1,2,4-trihydroxybenzene), a intermediate in the degradation of a large variety of aromatic compounds including some polychloro- and nitroaromatic pollutants, to form...; Region: 1,2-HQD; cd03461 114615005937 catechol 1,2-dioxygenase, proteobacterial; Region: catechol_proteo; TIGR02439 114615005938 dimer interface [polypeptide binding]; other site 114615005939 active site 114615005940 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 114615005941 aminoethylphosphonate catabolism associated LysR family transcriptional regulator; Region: phn_lysR; TIGR03339 114615005942 The C-terminal substrate binding of LysR-type transcriptional regulator (CbbR) of RubisCO operon, which is involved in the carbon dioxide fixation, contains the type 2 periplasmic binding fold; Region: PBP2_CbbR_RubisCO_like; cd08419 114615005943 putative dimerization interface [polypeptide binding]; other site 114615005944 ribulose bisophosphate carboxylase; Reviewed; Region: rbcL; PRK04208 114615005945 Ribulose bisphosphate carboxylase large chain; Region: RuBisCO_large; cl08232 114615005946 dimer interface [polypeptide binding]; other site 114615005947 catalytic residue [active] 114615005948 metal binding site [ion binding]; metal-binding site 114615005949 Ribulose bisphosphate carboxylase/oxygenase (Rubisco), small subunit. Rubisco is a bifunctional enzyme catalyzes the initial steps of two opposing metabolic pathways: photosynthetic carbon fixation and the competing process of photorespiration. Rubisco...; Region: RuBisCO_small; cd03527 114615005950 multimerization interface [polypeptide binding]; other site 114615005951 Carboxysome shell peptide mid-region; Region: CsoS2_M; pfam12288 114615005952 Carboxysome Shell Carbonic Anhydrase; Region: CsoSCA; cl07510 114615005953 Ethanolamine utilisation protein and carboxysome structural protein domain family; Region: EutN_CcmL; cd01614 114615005954 Hexamer/Pentamer interface [polypeptide binding]; other site 114615005955 central pore; other site 114615005956 Ethanolamine utilisation protein and carboxysome structural protein domain family; Region: EutN_CcmL; cd01614 114615005957 Hexamer/Pentamer interface [polypeptide binding]; other site 114615005958 central pore; other site 114615005959 Carboxysome Shell 1 (CsoS1); Bacterial Micro-Compartment (BCM) domain; Region: BMC_CsoS1; cd07058 114615005960 Hexamer interface [polypeptide binding]; other site 114615005961 Hexagonal pore residue; other site 114615005962 Hexagonal pore; other site 114615005963 Carboxysome Shell 1 (CsoS1); Bacterial Micro-Compartment (BCM) domain; Region: BMC_CsoS1; cd07058 114615005964 Hexamer interface [polypeptide binding]; other site 114615005965 Hexagonal pore residue; other site 114615005966 Hexagonal pore; other site 114615005967 PCD_DCoH: The bifunctional protein pterin-4alpha-carbinolamine dehydratase (PCD), also known as DCoH (dimerization cofactor of hepatocyte nuclear factor-1), is both a transcription activator and a metabolic enzyme. DCoH stimulates gene expression by...; Region: PCD_DCoH; cl00942 114615005968 aromatic arch; other site 114615005969 DCoH dimer interaction site [polypeptide binding]; other site 114615005970 DCoH /HNF-1 dimer interaction site [polypeptide binding]; other site 114615005971 DCoH tetramer interaction site [polypeptide binding]; other site 114615005972 substrate binding site [chemical binding]; other site 114615005973 hypothetical protein; Provisional; Region: PRK08999 114615005974 The MutT pyrophosphohydrolase is a prototypical Nudix hydrolase that catalyzes the hydrolysis of nucleoside and deoxynucleoside triphosphates (NTPs and dNTPs) by substitution at a beta-phosphorus to yield a nucleotide monophosphate (NMP) and inorganic...; Region: MutT_pyrophosphohydrolase; cd03425 114615005975 active site 114615005976 8-oxo-dGMP binding site [chemical binding]; other site 114615005977 nudix motif; other site 114615005978 metal binding site [ion binding]; metal-binding site 114615005979 NADH-Ubiquinone oxidoreductase (complex I), chain 5 N-terminus; Region: Oxidored_q1_N; pfam00662 114615005980 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; cl14187 114615005981 Uncharacterized protein conserved in bacteria (DUF2309); Region: DUF2309; pfam10070 114615005982 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3002 114615005983 Transcription-repair coupling factor (superfamily II helicase) [DNA replication, recombination, and repair / Transcription]; Region: Mfd; COG1197 114615005984 CarD-like/TRCF domain; Region: CarD_TRCF; cl00588 114615005985 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 114615005986 ATP binding site [chemical binding]; other site 114615005987 putative Mg++ binding site [ion binding]; other site 114615005988 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 114615005989 nucleotide binding region [chemical binding]; other site 114615005990 ATP-binding site [chemical binding]; other site 114615005991 TRCF domain; Region: TRCF; cl04088 114615005992 PIN (PilT N terminus) domain: Superfamily; Region: PIN_SF; cl14812 114615005993 CheB methylesterase; Region: CheB_methylest; pfam01339 114615005994 CheB methylesterase; Region: CheB_methylest; pfam01339 114615005995 Methyltransferase, chemotaxis proteins; Region: MeTrc; smart00138 114615005996 CheR methyltransferase, all-alpha domain; Region: CheR_N; pfam03705 114615005997 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cl12011 114615005998 Chromosome segregation ATPases [Cell division and chromosome partitioning]; Region: Smc; COG1196 114615005999 Leucine-rich repeats of kinetochore protein Cenp-F/LEK1; Region: Cenp-F_leu_zip; pfam10473 114615006000 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920 114615006001 Histidine kinase; Region: HisKA_2; cl06527 114615006002 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 114615006003 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 114615006004 ligand binding site [chemical binding]; other site 114615006005 flexible hinge region; other site 114615006006 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 114615006007 Uncharacterized iron-regulated membrane protein [Function unknown]; Region: PiuB; COG3182 114615006008 TonB-dependent siderophore receptor; Region: TonB-siderophor; TIGR01783 114615006009 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 114615006010 N-terminal plug; other site 114615006011 ligand-binding site [chemical binding]; other site 114615006012 Sodium:dicarboxylate symporter family; Region: SDF; cl00573 114615006013 NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252 114615006014 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 114615006015 Signal transduction histidine kinase regulating C4-dicarboxylate transport system [Signal transduction mechanisms]; Region: COG4191 114615006016 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via trans-...; Region: HisKA; cd00082 114615006017 dimer interface [polypeptide binding]; other site 114615006018 phosphorylation site [posttranslational modification] 114615006019 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 114615006020 ATP binding site [chemical binding]; other site 114615006021 Mg2+ binding site [ion binding]; other site 114615006022 G-X-G motif; other site 114615006023 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204 114615006024 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156 114615006025 active site 114615006026 phosphorylation site [posttranslational modification] 114615006027 intermolecular recognition site; other site 114615006028 dimerization interface [polypeptide binding]; other site 114615006029 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes...; Region: AAA; cd00009 114615006030 Walker A motif; other site 114615006031 ATP binding site [chemical binding]; other site 114615006032 Walker B motif; other site 114615006033 arginine finger; other site 114615006034 Bacterial regulatory protein, Fis family; Region: HTH_8; cl01091 114615006035 This group of proteins belong to a large family of YjgF/YER057c/UK114-like proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence...; Region: YjgF_YER057c_UK114_like_2; cd06150 114615006036 homotrimer interaction site [polypeptide binding]; other site 114615006037 putative active site [active] 114615006038 ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components [Inorganic ion transport and metabolism]; Region: TauA; COG0715 114615006039 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and...; Region: PBPb; cd00134 114615006040 substrate binding pocket [chemical binding]; other site 114615006041 membrane-bound complex binding site; other site 114615006042 Dehydratase family; Region: ILVD_EDD; cl00340 114615006043 dihydroxy-acid dehydratase; Region: ilvD; TIGR00110 114615006044 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 114615006045 NrtD and SsuB are the ATP-binding subunits of the bacterial ABC-type nitrate and sulfonate transport systems, respectively. ABC transporters are a large family of proteins involved in the transport of a wide variety of different compounds, like sugars...; Region: ABC_NrtD_SsuB_transporters; cd03293 114615006046 Walker A/P-loop; other site 114615006047 ATP binding site [chemical binding]; other site 114615006048 Q-loop/lid; other site 114615006049 ABC transporter signature motif; other site 114615006050 Walker B; other site 114615006051 D-loop; other site 114615006052 H-loop/switch region; other site 114615006053 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261 114615006054 dimer interface [polypeptide binding]; other site 114615006055 conserved gate region; other site 114615006056 putative PBP binding loops; other site 114615006057 ABC-ATPase subunit interface; other site 114615006058 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cl00427 114615006059 Leucyl aminopeptidase (aminopeptidase T) [Amino acid transport and metabolism]; Region: AmpS; COG2309 114615006060 3-hydroxybutyryl-CoA dehydrogenase; Validated; Region: PRK08269 114615006061 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 114615006062 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 114615006063 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 114615006064 NAD/NADP octopine/nopaline dehydrogenase, alpha-helical domain; Region: Octopine_DH; pfam02317 114615006065 Acyl-protein synthetase, LuxE; Region: LuxE; cl10450 114615006066 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK06187 114615006067 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 114615006068 Acyl-CoA dehydrogenase, N-terminal domain; Region: Acyl-CoA_dh_N; pfam02771 114615006069 Acyl-CoA dehydrogenase; Region: ACAD; cd00567 114615006070 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 114615006071 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 114615006072 classical (c) SDRs; Region: SDR_c; cd05233 114615006073 NAD(P) binding site [chemical binding]; other site 114615006074 active site 114615006075 enoyl-CoA hydratase; Provisional; Region: PRK08258 114615006076 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase...; Region: crotonase-like; cd06558 114615006077 substrate binding site [chemical binding]; other site 114615006078 oxyanion hole (OAH) forming residues; other site 114615006079 trimer interface [polypeptide binding]; other site 114615006080 salicylyl-CoA 5-hydroxylase; Reviewed; Region: PRK08255 114615006081 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 114615006082 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 114615006083 Old yellow enzyme (OYE) YqjM-like FMN binding domain. YqjM is involved in the oxidative stress response of Bacillus subtilis. Like the other OYE members, each monomer of YqjM contains FMN as a non-covalently bound cofactor and uses NADPH as a reducing...; Region: OYE_YqiM_FMN; cd02932 114615006084 active site 114615006085 FMN binding site [chemical binding]; other site 114615006086 substrate binding site [chemical binding]; other site 114615006087 homotetramer interface [polypeptide binding]; other site 114615006088 catalytic residue [active] 114615006089 hypothetical protein; Provisional; Region: PRK07538 114615006090 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 114615006091 Cupin domain; Region: Cupin_2; cl09118 114615006092 ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683 114615006093 Type I periplasmic binding component of active transport systems that are predicted to be involved in 2-nitrobenzoic acid degradation pathway; Region: PBP1_Nba_like; cd06359 114615006094 putative ligand binding site [chemical binding]; other site 114615006095 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 114615006096 Acyl-coenzyme A synthetases/AMP-(fatty) acid ligases [Lipid metabolism]; Region: Acs; COG0365 114615006097 Acyl-protein synthetase, LuxE; Region: LuxE; cl10450 114615006098 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 114615006099 homotrimer interaction site [polypeptide binding]; other site 114615006100 putative active site [active] 114615006101 DNA mismatch repair protein; Reviewed; Region: mutL; PRK00095 114615006102 Protein of unknown function (DUF1236); Region: DUF1236; pfam06823 114615006103 Protein containing von Willebrand factor type A (vWA) domain [General function prediction only]; Region: CoxE; COG3552 114615006104 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057 114615006105 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes...; Region: AAA; cd00009 114615006106 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 114615006107 Walker A motif; other site 114615006108 ATP binding site [chemical binding]; other site 114615006109 Walker B motif; other site 114615006110 arginine finger; other site 114615006111 TspO/MBR family; Region: TspO_MBR; cl01379 114615006112 nitrogen assimilation transcriptional regulator; Provisional; Region: PRK11233 114615006113 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 114615006114 The C-teminal substrate binding domain of LysR-like nitrogen assimilation control (NAC) protein, contains the type 2 periplasmic binding fold; Region: PBP2_Nac; cd08433 114615006115 putative dimerization interface [polypeptide binding]; other site 114615006116 benzoate transport; Region: 2A0115; TIGR00895 114615006117 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 114615006118 putative substrate translocation pore; other site 114615006119 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 114615006120 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have...; Region: metallo-dependent_hydrolases; cl00281 114615006121 Demethylmenaquinone methyltransferase; Region: Methyltransf_6; cl00480 114615006122 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084 114615006123 Domain of unknown function (DUF1932); Region: DUF1932; pfam09130 114615006124 Predicted metal-dependent hydrolase of the TIM-barrel fold [General function prediction only]; Region: COG3618 114615006125 2-pyrone-4,6-dicarboxylic acid (PDC) hydrolase hydrolyzes PDC to yield 4-oxalomesaconic acid (OMA) or its tautomer, 4-carboxy-2-hydroxymuconic acid (CHM). This reaction is part of the protocatechuate (PCA) 4,5-cleavage pathway. PCA is one of the most...; Region: PDC_hydrolase; cd01311 114615006126 active site 114615006127 The A subunit of Protocatechuate 4,5-dioxygenase (LigAB) is the smaller, non-catalytic subunit; Region: PCA_45_Doxase_A; cd07924 114615006128 tetramer interface [polypeptide binding]; other site 114615006129 dimer interface [polypeptide binding]; other site 114615006130 active site 114615006131 Subunit B of the Class III extradiol dioxygenase, Protocatechuate 4,5-dioxygenase, which catalyzes the oxidization and subsequent ring-opening of protocatechuate; Region: PCA_45_Dioxygenase_B; cd07364 114615006132 Catalytic LigB subunit of aromatic ring-opening dioxygenase; Region: LigB; pfam02900 114615006133 active site 114615006134 Fe(II) binding site [ion binding]; other site 114615006135 dimer interface [polypeptide binding]; other site 114615006136 tetramer interface [polypeptide binding]; other site 114615006137 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 114615006138 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 114615006139 ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683 114615006140 Periplasmic binding domain of ATP-binding cassette transporter-like systems that belong to the type I periplasmic binding fold protein superfamily; Region: PBP1_ABC_transporter_LIVBP_like; cd06268 114615006141 ligand binding site [chemical binding]; other site 114615006142 Predicted metal-dependent hydrolase of the TIM-barrel fold [General function prediction only]; Region: COG3618 114615006143 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have...; Region: metallo-dependent_hydrolases; cl00281 114615006144 active site 114615006145 shikimate 5-dehydrogenase; Reviewed; Region: aroE; PRK00258 114615006146 Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501 114615006147 NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065 114615006148 shikimate binding site; other site 114615006149 NAD(P) binding site [chemical binding]; other site 114615006150 AMP nucleosidase; Provisional; Region: PRK08292 114615006151 Bacterial AMP nucleoside phosphorylase N-terminus; Region: AMNp_N; pfam10423 114615006152 Phosphorylase superfamily; Region: PNP_UDP_1; cl00303 114615006153 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 114615006154 Old yellow enzyme (OYE)-related FMN binding domain, group 5. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a reducing agent with oxygens, quinones, and alpha,beta-unsaturated aldehydes and ketones, and can act as...; Region: OYE_like_5_FMN; cd04747 114615006155 NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902 114615006156 putative active site [active] 114615006157 putative FMN binding site [chemical binding]; other site 114615006158 putative substrate binding site [chemical binding]; other site 114615006159 putative catalytic residue [active] 114615006160 Cytochrome P450; Region: p450; cl12078 114615006161 4-hydroxyphenylacetate catabolism regulatory protein HpaA; Region: HpaA; TIGR02297 114615006162 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 114615006163 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 114615006164 4-hydroxybenzoate 3-monooxygenase; Validated; Region: PRK08243 114615006165 Tannase and feruloyl esterase; Region: Tannase; pfam07519 114615006166 Transposase domain (DUF772); Region: DUF772; cl12084 114615006167 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 114615006168 GAF domain; Region: GAF; cl00853 114615006169 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 114615006170 metal binding site [ion binding]; metal-binding site 114615006171 active site 114615006172 I-site; other site 114615006173 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 114615006174 DNA binding site [nucleotide binding] 114615006175 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: RbsB; COG1879 114615006176 Periplasmic sugar-binding domain of uncharacterized transport systems; Region: PBP1_uncharacterized_sugar_binding; cd06307 114615006177 putative ligand binding site [chemical binding]; other site 114615006178 D-xylulose kinases, Escherichia coli xylulokinase-like subgroup; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_D-XK_EcXK-like; cd07808 114615006179 N- and C-terminal domain interface [polypeptide binding]; other site 114615006180 D-xylulose kinase; Region: XylB; TIGR01312 114615006181 active site 114615006182 catalytic site [active] 114615006183 metal binding site [ion binding]; metal-binding site 114615006184 xylulose binding site [chemical binding]; other site 114615006185 putative ATP binding site [chemical binding]; other site 114615006186 homodimer interface [polypeptide binding]; other site 114615006187 xylose isomerase; Region: PLN02923 114615006188 L-rhamnose isomerase (RhaA); Region: RhaA; cl09945 114615006189 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411 114615006190 This family represents the domain I of the carbohydrate uptake proteins that transport only monosaccharides (Monos). The Carb_Monos family is involved in the uptake of monosaccharides, such as pentoses (such as xylose, arabinose, and ribose) and...; Region: ABC_Carb_Monos_I; cd03216 114615006191 Walker A/P-loop; other site 114615006192 ATP binding site [chemical binding]; other site 114615006193 Q-loop/lid; other site 114615006194 ABC transporter signature motif; other site 114615006195 Walker B; other site 114615006196 D-loop; other site 114615006197 H-loop/switch region; other site 114615006198 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 114615006199 TM-ABC transporter signature motif; other site 114615006200 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: RbsB; COG1879 114615006201 Periplasmic sugar-binding domain of active transport systems that are members of the type I periplasmic binding protein (PBP1) superfamily; Region: PBP1_ABC_sugar_binding_like; cd01536 114615006202 ligand binding site [chemical binding]; other site 114615006203 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 114615006204 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 114615006205 Coenzyme A binding pocket [chemical binding]; other site 114615006206 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 114615006207 active site 2 [active] 114615006208 active site 1 [active] 114615006209 hypothetical protein; Provisional; Region: PRK12472 114615006210 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 114615006211 Spc7 kinetochore protein; Region: Spc7; smart00787 114615006212 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 114615006213 CoenzymeA binding site [chemical binding]; other site 114615006214 subunit interaction site [polypeptide binding]; other site 114615006215 PHB binding site; other site 114615006216 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 114615006217 CoenzymeA binding site [chemical binding]; other site 114615006218 subunit interaction site [polypeptide binding]; other site 114615006219 PHB binding site; other site 114615006220 Uncharacterized protein conserved in bacteria (DUF2200); Region: DUF2200; cl02047 114615006221 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 114615006222 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 114615006223 Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5,10-...; Region: DHFR; cl00161 114615006224 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 114615006225 Flavin containing amine oxidoreductase; Region: Amino_oxidase; pfam01593 114615006226 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 114615006227 Sulfatase; Region: Sulfatase; cl10460 114615006228 Sulfatase; Region: Sulfatase; cl10460 114615006229 Sulfatase; Region: Sulfatase; cl10460 114615006230 Transcriptional regulator [Transcription]; Region: LysR; COG0583 114615006231 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 114615006232 The C-terminal substrate binding domain of LysR-type transcriptional regulators that involved in the catabolism of nitroaromatic/naphthalene compounds and that of related regulators; contains the type 2 periplasmic binding fold; Region: PBP2_Nitroaromatics_like; cd08417 114615006233 substrate binding pocket [chemical binding]; other site 114615006234 dimerization interface [polypeptide binding]; other site 114615006235 The A subunit of Uncharacterized proteins with similarity to Protocatechuate 4,5-dioxygenase (LigAB); Region: LigA_like_1; cd07925 114615006236 putative dimer interface [polypeptide binding]; other site 114615006237 putative tetramer interface [polypeptide binding]; other site 114615006238 putative active site [active] 114615006239 The B subunit of unknown Class III extradiol dioxygenases with similarity to Protocatechuate 4,5-dioxygenase; Region: PCA_45_Doxase_B_like_1; cd07949 114615006240 Catalytic LigB subunit of aromatic ring-opening dioxygenase; Region: LigB; pfam02900 114615006241 putative active site [active] 114615006242 Fe(II) binding site [ion binding]; other site 114615006243 putative dimer interface [polypeptide binding]; other site 114615006244 putative tetramer interface [polypeptide binding]; other site 114615006245 Domain of Unknown Function with PDB structure; Region: DUF3861; pfam12977 114615006246 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 114615006247 multidrug efflux protein; Reviewed; Region: PRK09579 114615006248 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 114615006249 NodT family; Region: outer_NodT; TIGR01845 114615006250 Outer membrane efflux protein; Region: OEP; pfam02321 114615006251 Outer membrane efflux protein; Region: OEP; pfam02321 114615006252 Transcriptional regulators [Transcription]; Region: MarR; COG1846 114615006253 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 114615006254 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have...; Region: metallo-dependent_hydrolases; cl00281 114615006255 Bacterial periplasmic substrate-binding proteins; Region: PBPb; smart00062 114615006256 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and...; Region: PBPb; cd00134 114615006257 substrate binding pocket [chemical binding]; other site 114615006258 membrane-bound complex binding site; other site 114615006259 hinge residues; other site 114615006260 Sodium:dicarboxylate symporter family; Region: SDF; cl00573 114615006261 Predicted metal-dependent hydrolase of the TIM-barrel fold [General function prediction only]; Region: COG3618 114615006262 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have...; Region: metallo-dependent_hydrolases; cl00281 114615006263 active site 114615006264 MmgE/PrpD family; Region: MmgE_PrpD; cl00912 114615006265 acetyl-CoA acetyltransferase; Provisional; Region: PRK06025 114615006266 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 114615006267 dimer interface [polypeptide binding]; other site 114615006268 active site 114615006269 Chloride channel protein EriC [Inorganic ion transport and metabolism]; Region: EriC; COG0038 114615006270 CLC voltage-gated chloride channel. The ClC chloride channels catalyse the selective flow of Cl- ions across cell membranes, thereby regulating electrical excitation in skeletal muscle and the flow of salt and water across epithelial barriers. This...; Region: Voltage_gated_ClC; cd00400 114615006271 Cl- selectivity filter; other site 114615006272 Cl- binding residues [ion binding]; other site 114615006273 pore gating glutamate residue; other site 114615006274 dimer interface [polypeptide binding]; other site 114615006275 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in association with the metalloprotease peptidase M50. CBS is a small domain originally identified in cystathionine beta-synthase and subsequently found in a...; Region: CBS_pair_M50_like; cd04801 114615006276 Membrane bound L-sorbosone dehydrogenase; Region: SNDH; pfam12303 114615006277 Glucose/sorbosone dehydrogenases [Carbohydrate transport and metabolism]; Region: COG2133 114615006278 Glucose / Sorbosone dehydrogenase; Region: GSDH; pfam07995 114615006279 cytochrome o ubiquinol oxidase subunit II; Provisional; Region: PRK10525 114615006280 Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; cl11412 114615006281 Ubiquinol oxidase subunit III subfamily. Ubiquinol oxidase, the terminal oxidase in the respiratory chains of aerobic bacteria, is a multi-chain transmembrane protein located in the cell membrane. It catalyzes the reduction of O2 and simultaneously...; Region: Ubiquinol_oxidase_III; cd02863 114615006282 Subunit I/III interface [polypeptide binding]; other site 114615006283 Subunit III/IV interface [polypeptide binding]; other site 114615006284 Prokaryotic Cytochrome C oxidase subunit IV; Region: COX4_pro; cl01204 114615006285 Staphylococcal nuclease homologues. SNase homologues are found in bacteria, archaea, and eukaryotes. They contain no disufide bonds; Region: SNc; cl00140 114615006286 Catalytic site; other site 114615006287 Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic...; Region: Tryp_SPc; cl00149 114615006288 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind C-...; Region: PDZ_serine_protease; cd00987 114615006289 protein binding site [polypeptide binding]; other site 114615006290 Isochorismatase family; Region: Isochorismatase; pfam00857 114615006291 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cd00431 114615006292 catalytic triad [active] 114615006293 conserved cis-peptide bond; other site 114615006294 Sulfate transporter family; Region: Sulfate_transp; cl00967 114615006295 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing...; Region: TlpA_like_family; cd02966 114615006296 catalytic residues [active] 114615006297 DsrE/DsrF-like family; Region: DrsE; cl00672 114615006298 Transcriptional regulator [Transcription]; Region: LysR; COG0583 114615006299 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 114615006300 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 114615006301 putative effector binding pocket; other site 114615006302 dimerization interface [polypeptide binding]; other site 114615006303 Cytochrome c [Energy production and conversion]; Region: COG3258 114615006304 Cytochrome c [Energy production and conversion]; Region: COG3258 114615006305 Sulphur oxidation protein SoxZ; Region: SoxZ; pfam08770 114615006306 Predicted secreted protein [Function unknown]; Region: COG5501; cl02313 114615006307 Cytochrome c; Region: Cytochrom_C; cl11414 114615006308 NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252 114615006309 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 114615006310 Flavocytochrome c sulphide dehydrogenase, flavin-binding; Region: FCSD-flav_bind; pfam09242 114615006311 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 114615006312 Aerobic-type carbon monoxide dehydrogenase, large subunit CoxL/CutL homologs [Energy production and conversion]; Region: CoxL; COG1529 114615006313 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; cl03161 114615006314 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 114615006315 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 114615006316 Aerobic-type carbon monoxide dehydrogenase, small subunit CoxS/CutS homologs [Energy production and conversion]; Region: CoxS; COG2080 114615006317 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cl00159 114615006318 [2Fe-2S] binding domain; Region: Fer2_2; pfam01799 114615006319 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 114615006320 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 114615006321 putative substrate translocation pore; other site 114615006322 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-...; Region: CBS_pair_10; cd04623 114615006323 Cupin domain; Region: Cupin_2; cl09118 114615006324 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 114615006325 DNA binding site [nucleotide binding] 114615006326 Curli production assembly/transport component CsgG; Region: CsgG; cl00639 114615006327 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109 114615006328 Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072 114615006329 Transcriptional regulators [Transcription]; Region: GntR; COG1802 114615006330 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 114615006331 DNA-binding site [nucleotide binding]; DNA binding site 114615006332 FCD domain; Region: FCD; cl11656 114615006333 Biotin synthase and related enzymes [Coenzyme metabolism]; Region: BioB; COG0502 114615006334 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster...; Region: Radical_SAM; cd01335 114615006335 FeS/SAM binding site; other site 114615006336 Biotin and Thiamin Synthesis associated domain; Region: BATS; cl06149 114615006337 Alkyl sulfatase and related hydrolases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2015 114615006338 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 114615006339 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 114615006340 metal binding site [ion binding]; metal-binding site 114615006341 active site 114615006342 I-site; other site 114615006343 This family is most closely related to the GT1 family of glycosyltransferases. aviGT4 in Streptomyces viridochromogenes has been shown to be involved in biosynthesis of oligosaccharide antibiotic avilamycin A. Inactivation of aviGT4 resulted in a...; Region: GT1_AviGT4_like; cd03802 114615006344 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 114615006345 putative ADP-binding pocket [chemical binding]; other site 114615006346 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 114615006347 ABC transporter transmembrane region; Region: ABC_membrane; cl00549 114615006348 MTABC3 (also known as ABCB6) is a mitochondrial ATP-binding cassette protein involved in iron homeostasis and one of four ABC transporters expressed in the mitochondrial inner membrane, the other three being MDL1(ABC7), MDL2, and ATM1. In fact, the...; Region: ABC_MTABC3_MDL1_MDL2; cd03249 114615006349 Walker A/P-loop; other site 114615006350 ATP binding site [chemical binding]; other site 114615006351 Q-loop/lid; other site 114615006352 ABC transporter signature motif; other site 114615006353 Walker B; other site 114615006354 D-loop; other site 114615006355 H-loop/switch region; other site 114615006356 Glycogen debranching enzyme [Carbohydrate transport and metabolism]; Region: GDB1; COG3408 114615006357 Bacterial alpha-L-rhamnosidase; Region: Bac_rhamnosid; cl01801 114615006358 Bacterial alpha-L-rhamnosidase; Region: Bac_rhamnosid; cl01801 114615006359 Photosynthetic reaction center (RC) complex, subunit H; RC is an integral membrane protein-pigment complex which catalyzes light-induced reduction of ubiquinone to ubiquinol, generating a transmembrane electrochemical gradient of protons used to...; Region: PRCH; cl09959 114615006360 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 114615006361 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 114615006362 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 114615006363 ligand binding site [chemical binding]; other site 114615006364 flexible hinge region; other site 114615006365 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 114615006366 putative switch regulator; other site 114615006367 non-specific DNA interactions [nucleotide binding]; other site 114615006368 DNA binding site [nucleotide binding] 114615006369 sequence specific DNA binding site [nucleotide binding]; other site 114615006370 putative cAMP binding site [chemical binding]; other site 114615006371 Response regulator receiver domain; Region: Response_reg; pfam00072 114615006372 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156 114615006373 active site 114615006374 phosphorylation site [posttranslational modification] 114615006375 intermolecular recognition site; other site 114615006376 dimerization interface [polypeptide binding]; other site 114615006377 response regulator FixJ; Provisional; Region: fixJ; PRK09390 114615006378 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156 114615006379 active site 114615006380 phosphorylation site [posttranslational modification] 114615006381 intermolecular recognition site; other site 114615006382 dimerization interface [polypeptide binding]; other site 114615006383 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors...; Region: LuxR_C_like; cd06170 114615006384 DNA binding residues [nucleotide binding] 114615006385 dimerization interface [polypeptide binding]; other site 114615006386 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 114615006387 PAS fold; Region: PAS_3; pfam08447 114615006388 putative active site [active] 114615006389 heme pocket [chemical binding]; other site 114615006390 PAS domain S-box; Region: sensory_box; TIGR00229 114615006391 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 114615006392 putative active site [active] 114615006393 heme pocket [chemical binding]; other site 114615006394 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via trans-...; Region: HisKA; cl00080 114615006395 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 114615006396 ATP binding site [chemical binding]; other site 114615006397 Mg2+ binding site [ion binding]; other site 114615006398 G-X-G motif; other site 114615006399 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-...; Region: CBS_pair; cl09141 114615006400 Cytochrome cbb3 oxidase subunit I. Cytochrome cbb3 oxidase, the terminal oxidase in the respiratory chains of proteobacteria, is a multi-chain transmembrane protein located in the cell membrane. Like other cytochrome oxidases, it catalyzes the...; Region: cbb3_Oxidase_I; cd01661 114615006401 Low-spin heme binding site [chemical binding]; other site 114615006402 Putative water exit pathway; other site 114615006403 Binuclear center (active site) [active] 114615006404 Putative proton exit pathway; other site 114615006405 Cytochrome C oxidase, mono-heme subunit/FixO; Region: FixO; cl01130 114615006406 Cytochrome cbb oxidase CcoQ. Cytochrome cbb3 oxidase, the terminal oxidase in the respiratory chains of proteobacteria, is a multi-chain transmembrane protein located in the cell membrane. Like other cytochrome oxidases, it catalyzes the reduction of...; Region: cbb3_Oxidase_CcoQ; cl00282 114615006407 cytochrome c oxidase, cbb3-type, subunit III; Region: ccoP; TIGR00782 114615006408 Cytochrome c; Region: Cytochrom_C; cl11414 114615006409 Cytochrome c; Region: Cytochrom_C; cl11414 114615006410 cytochrome c oxidase accessory protein FixG; Region: ccoG_rdxA_fixG; TIGR02745 114615006411 4Fe-4S binding domain; Region: Fer4_5; pfam12801 114615006412 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved alpha-; Region: HCP_like; cl14655 114615006413 Ubp3 associated protein Bre5; Region: Bre5; pfam11614 114615006414 FixH; Region: FixH; cl01254 114615006415 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 114615006416 metal-binding site [ion binding] 114615006417 copper-(or silver)-translocating P-type ATPase; Region: ATPase-IB1_Cu; TIGR01511 114615006418 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 114615006419 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others...; Region: HAD_like; cl11391 114615006420 Cytochrome oxidase maturation protein cbb3-type; Region: CcoS; cl01253 114615006421 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 114615006422 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 114615006423 putative substrate translocation pore; other site 114615006424 Cupin domain; Region: Cupin_2; cl09118 114615006425 Peroxiredoxin (PRX)-like 2 family; hypothetical proteins that show sequence similarity to PRXs. Members of this group contain a CXXC motif, similar to TRX. The second cysteine in the motif corresponds to the peroxidatic cysteine of PRX, however, these...; Region: PRX_like2; cd02970 114615006426 putative catalytic residues [active] 114615006427 Transcriptional regulator [Transcription]; Region: LysR; COG0583 114615006428 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 114615006429 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 114615006430 dimerization interface [polypeptide binding]; other site 114615006431 Hypothetical patatin similar to Z1214 protein of Escherichia coli; Region: Pat_hypo_Ecoli_Z1214_like; cd07209 114615006432 Predicted esterase of the alpha-beta hydrolase superfamily [General function prediction only]; Region: RssA; COG1752 114615006433 nucleophile elbow; other site 114615006434 Patatin phospholipase; Region: DUF3734; pfam12536 114615006435 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 114615006436 Taxis toward Aspartate and Related amino acids and Homologs (TarH). The Tar chemoreceptor of Escherichia coli mediates attractant responses to aspartate, maltose, and phenol, repellent responses to Ni2+ and Co2+, and thermoresponses. These...; Region: TarH; cl00144 114615006437 glycogen synthase; Provisional; Region: glgA; PRK00654 114615006438 This family is most closely related to the GT1 family of glycosyltransferases. Glycogen synthase catalyzes the formation and elongation of the alpha-1,4-glucose backbone using ADP-glucose, the second and key step of glycogen biosynthesis. This family...; Region: GT1_Glycogen_synthase_DULL1_like; cd03791 114615006439 ADP-binding pocket [chemical binding]; other site 114615006440 homodimer interface [polypeptide binding]; other site 114615006441 CoA-transferase family III; Region: CoA_transf_3; cl00778 114615006442 Zn-dependent alcohol dehydrogenases [General function prediction only]; Region: AdhP; COG1064 114615006443 6-hydroxyhexanoate dehydrogenase; Region: 6_hydroxyhexanoate_dh_like; cd08240 114615006444 putative NAD(P) binding site [chemical binding]; other site 114615006445 catalytic Zn binding site [ion binding]; other site 114615006446 Isocitrate/isopropylmalate dehydrogenase; Region: Iso_dh; cl00445 114615006447 Sulfate transporter family; Region: Sulfate_transp; cl00967 114615006448 Permease family; Region: Xan_ur_permease; pfam00860 114615006449 Adenine deaminase [Nucleotide transport and metabolism]; Region: AdeC; COG1001 114615006450 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have...; Region: metallo-dependent_hydrolases; cl00281 114615006451 active site 114615006452 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have...; Region: metallo-dependent_hydrolases; cl00281 114615006453 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 114615006454 enoyl-CoA hydratase; Provisional; Region: PRK06127 114615006455 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase...; Region: crotonase-like; cd06558 114615006456 substrate binding site [chemical binding]; other site 114615006457 oxyanion hole (OAH) forming residues; other site 114615006458 trimer interface [polypeptide binding]; other site 114615006459 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 114615006460 non-specific DNA binding site [nucleotide binding]; other site 114615006461 salt bridge; other site 114615006462 sequence-specific DNA binding site [nucleotide binding]; other site 114615006463 Transcriptional regulator [Transcription]; Region: LysR; COG0583 114615006464 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 114615006465 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 114615006466 dimerization interface [polypeptide binding]; other site 114615006467 Cytochrome C biogenesis protein transmembrane region; Region: DsbD; cl00515 114615006468 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920 114615006469 Histidine kinase; Region: HisKA_2; cl06527 114615006470 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 114615006471 Beta-lactamase; Region: Beta-lactamase; cl01009 114615006472 Hydroxyquinol 1,2-dioxygenase (1,2-HQD) catalyzes the ring cleavage of hydroxyquinol (1,2,4-trihydroxybenzene), a intermediate in the degradation of a large variety of aromatic compounds including some polychloro- and nitroaromatic pollutants, to form...; Region: 1,2-HQD; cd03461 114615006473 catechol 1,2-dioxygenase, proteobacterial; Region: catechol_proteo; TIGR02439 114615006474 dimer interface [polypeptide binding]; other site 114615006475 active site 114615006476 ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components [Inorganic ion transport and metabolism]; Region: TauA; COG0715 114615006477 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 114615006478 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261 114615006479 putative PBP binding loops; other site 114615006480 dimer interface [polypeptide binding]; other site 114615006481 ABC-ATPase subunit interface; other site 114615006482 NrtD and SsuB are the ATP-binding subunits of the bacterial ABC-type nitrate and sulfonate transport systems, respectively. ABC transporters are a large family of proteins involved in the transport of a wide variety of different compounds, like sugars...; Region: ABC_NrtD_SsuB_transporters; cd03293 114615006483 nitrate transport ATP-binding subunits C and D; Region: ntrCD; TIGR01184 114615006484 Walker A/P-loop; other site 114615006485 ATP binding site [chemical binding]; other site 114615006486 Q-loop/lid; other site 114615006487 ABC transporter signature motif; other site 114615006488 Walker B; other site 114615006489 D-loop; other site 114615006490 H-loop/switch region; other site 114615006491 Globins are heme proteins, which bind and transport oxygen. This family summarizes a diverse set of homologous protein domains, including: (1) tetrameric vertebrate hemoglobins, which are the major protein component of erythrocytes and transport oxygen...; Region: globin; cd01040 114615006492 heme-binding site [chemical binding]; other site 114615006493 NAD(P)H-nitrite reductase [Energy production and conversion]; Region: NirB; COG1251 114615006494 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 114615006495 NasA, and NarB catalyze the reduction of nitrate to nitrite. Monomeric Nas is located in the cytoplasm and participates in nitrogen assimilation. Dimeric Nap is located in the periplasm and is coupled to quinol oxidation via a membrane-anchored...; Region: MopB_Nitrate-R-NapA-like; cd02754 114615006496 formate dehydrogenase, alpha subunit, archaeal-type; Region: Fdh-alpha; TIGR01591 114615006497 [4Fe-4S] binding site [ion binding]; other site 114615006498 molybdopterin cofactor binding site; other site 114615006499 NasA, and NarB catalyze the reduction of nitrate to nitrite. Monomeric Nas is located in the cytoplasm and participates in nitrogen assimilation. Dimeric Nap is located in the periplasm and is coupled to quinol oxidation via a membrane-anchored...; Region: MopB_CT_Nitrate-R-NapA-like; cd02791 114615006500 molybdopterin cofactor binding site; other site 114615006501 NAD(P)H-nitrite reductase [Energy production and conversion]; Region: NirB; COG1251 114615006502 BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; cl01093 114615006503 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and...; Region: Aldo_ket_red; cd06660 114615006504 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 114615006505 active site 114615006506 catalytic tetrad [active] 114615006507 EamA-like transporter family; Region: EamA; cl01037 114615006508 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 114615006509 EamA-like transporter family; Region: EamA; cl01037 114615006510 Fumarylacetoacetate (FAA) hydrolase family protein [General function prediction only]; Region: COG3970 114615006511 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; cl11421 114615006512 TRAP-type uncharacterized transport system, periplasmic component [General function prediction only]; Region: Imp; COG2358 114615006513 Tripartite tricarboxylate transporter family receptor; Region: TctC; cl15260 114615006514 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 114615006515 CDP-6-deoxy-delta-3,4-glucoseen reductase; Validated; Region: PRK07609 114615006516 catalytic loop [active] 114615006517 iron binding site [ion binding]; other site 114615006518 Iron-sulfur binding ferredoxin reductase (FNR) proteins combine the FAD and NAD(P) binding regions of FNR with an N-terminal Iron-Sulfur binding cluster domain. Ferredoxin-NADP+ (oxido)reductase is an FAD-containing enzyme that catalyzes the reversible...; Region: FNR_N-term_Iron_sulfur_binding; cd06194 114615006519 FAD binding pocket [chemical binding]; other site 114615006520 FAD binding motif [chemical binding]; other site 114615006521 phosphate binding motif [ion binding]; other site 114615006522 beta-alpha-beta structure motif; other site 114615006523 NAD binding pocket [chemical binding]; other site 114615006524 ferredoxin-type protein NapF; Region: napF; TIGR00402 114615006525 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 114615006526 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 114615006527 Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin...; Region: TPP_enzymes; cl01629 114615006528 TPP-binding site [chemical binding]; other site 114615006529 Pyrimidine (PYR) binding domain of thiamine pyrophosphate (TPP)-dependent enzymes; Region: TPP_enzyme_PYR; cl11410 114615006530 PYR/PP interface [polypeptide binding]; other site 114615006531 dimer interface [polypeptide binding]; other site 114615006532 TPP binding site [chemical binding]; other site 114615006533 Transketolase, C-terminal subunit [Carbohydrate transport and metabolism]; Region: COG3958 114615006534 Rhodococcus ruber 6-oxolauric acid dehydrogenase-like; Region: ALDH_CddD_SSP0762; cd07138 114615006535 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 114615006536 NAD binding site [chemical binding]; other site 114615006537 catalytic residues [active] 114615006538 Gluconolactonase [Carbohydrate transport and metabolism]; Region: COG3386 114615006539 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 114615006540 NAD(P) binding site [chemical binding]; other site 114615006541 active site 114615006542 Dehydratase family; Region: ILVD_EDD; cl00340 114615006543 dihydroxy-acid dehydratase; Region: ilvD; TIGR00110 114615006544 enoyl-CoA hydratase; Provisional; Region: PRK06688 114615006545 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase...; Region: crotonase-like; cd06558 114615006546 substrate binding site [chemical binding]; other site 114615006547 oxyanion hole (OAH) forming residues; other site 114615006548 trimer interface [polypeptide binding]; other site 114615006549 phenylpropionate dioxygenase ferredoxin reductase subunit; Provisional; Region: PRK09754 114615006550 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 114615006551 pfkB family carbohydrate kinase; Region: PfkB; pfam00294 114615006552 Ribokinase catalyses the phosphorylation of ribose to ribose-5-phosphate using ATP. This reaction is the first step in the ribose metabolism. It traps ribose within the cell after uptake and also prepares the sugar for use in the synthesis of...; Region: ribokinase; cd01174 114615006553 substrate binding site [chemical binding]; other site 114615006554 dimer interface [polypeptide binding]; other site 114615006555 ATP binding site [chemical binding]; other site 114615006556 Ribokinase-like subgroup B. Found in bacteria and plants, this subgroup is part of the ribokinase/pfkB superfamily. Its oligomerization state is unknown at this time; Region: ribokinase_group_B; cd01945 114615006557 pfkB family carbohydrate kinase; Region: PfkB; pfam00294 114615006558 substrate binding site [chemical binding]; other site 114615006559 ATP binding site [chemical binding]; other site 114615006560 Glutamate dehydrogenase/leucine dehydrogenase [Amino acid transport and metabolism]; Region: GdhA; COG0334 114615006561 Glu/Leu/Phe/Val dehydrogenase, dimerisation domain; Region: ELFV_dehydrog_N; pfam02812 114615006562 NAD(P) binding domain of glutamate dehydrogenase, subgroup 1; Region: NAD_bind_1_Glu_DH; cd01076 114615006563 NAD(P) binding site [chemical binding]; other site 114615006564 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 114615006565 active site 114615006566 metal binding site [ion binding]; metal-binding site 114615006567 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 114615006568 active site 114615006569 metal binding site [ion binding]; metal-binding site 114615006570 NmrA-like family; Region: NmrA; pfam05368 114615006571 atypical (a) SDRs, subgroup 5; Region: SDR_a5; cd05243 114615006572 NAD(P) binding site [chemical binding]; other site 114615006573 putative active site [active] 114615006574 putative Helix-turn-helix domain of transposase IS66; Region: HTH_Tnp_IS66; cl14891 114615006575 Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050 114615006576 Cytochrome P450; Region: p450; cl12078 114615006577 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 114615006578 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 114615006579 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 114615006580 multidrug efflux protein; Reviewed; Region: PRK09579 114615006581 Protein export membrane protein; Region: SecD_SecF; cl14618 114615006582 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 114615006583 N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911 114615006584 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261 114615006585 dimer interface [polypeptide binding]; other site 114615006586 conserved gate region; other site 114615006587 putative PBP binding loops; other site 114615006588 ABC-ATPase subunit interface; other site 114615006589 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 114615006590 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261 114615006591 dimer interface [polypeptide binding]; other site 114615006592 conserved gate region; other site 114615006593 putative PBP binding loops; other site 114615006594 ABC-ATPase subunit interface; other site 114615006595 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_5; cd08511 114615006596 Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496 114615006597 Family of unknown function (DUF1028); Region: DUF1028; pfam06267 114615006598 Gamma-glutamyltransferase [Amino acid transport and metabolism]; Region: Ggt; cl08040 114615006599 Gamma-glutamyltranspeptidase; Region: G_glu_transpept; pfam01019 114615006600 dipeptide transporter ATP-binding subunit; Provisional; Region: dppF; PRK11308 114615006601 The ABC transporter subfamily specific for the transport of dipeptides, oligopeptides (OppD), and nickel (NikDE). The NikABCDE system of E. coli belongs to this family and is composed of the periplasmic binding protein NikA, two integral membrane...; Region: ABC_NikE_OppD_transporters; cd03257 114615006602 Walker A/P-loop; other site 114615006603 ATP binding site [chemical binding]; other site 114615006604 Q-loop/lid; other site 114615006605 ABC transporter signature motif; other site 114615006606 Walker B; other site 114615006607 D-loop; other site 114615006608 H-loop/switch region; other site 114615006609 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 114615006610 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 114615006611 The ABC transporter subfamily specific for the transport of dipeptides, oligopeptides (OppD), and nickel (NikDE). The NikABCDE system of E. coli belongs to this family and is composed of the periplasmic binding protein NikA, two integral membrane...; Region: ABC_NikE_OppD_transporters; cd03257 114615006612 Walker A/P-loop; other site 114615006613 ATP binding site [chemical binding]; other site 114615006614 Q-loop/lid; other site 114615006615 ABC transporter signature motif; other site 114615006616 Walker B; other site 114615006617 D-loop; other site 114615006618 H-loop/switch region; other site 114615006619 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 114615006620 dipeptide transporter; Provisional; Region: PRK10913 114615006621 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261 114615006622 dimer interface [polypeptide binding]; other site 114615006623 conserved gate region; other site 114615006624 putative PBP binding loops; other site 114615006625 ABC-ATPase subunit interface; other site 114615006626 nickel transporter permease NikB; Provisional; Region: PRK10352 114615006627 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261 114615006628 dimer interface [polypeptide binding]; other site 114615006629 conserved gate region; other site 114615006630 putative PBP binding loops; other site 114615006631 ABC-ATPase subunit interface; other site 114615006632 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 114615006633 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_2; cd08498 114615006634 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 114615006635 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 114615006636 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 114615006637 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 114615006638 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 114615006639 Phasin protein; Region: Phasin_2; cl11491 114615006640 PaaX-like protein; Region: PaaX; pfam07848 114615006641 phenylacetic acid degradation operon negative regulatory protein PaaX; Region: PaaX_trns_reg; TIGR02277 114615006642 PaaX-like protein C-terminal domain; Region: PaaX_C; pfam08223 114615006643 Phenylacetic acid catabolic protein; Region: PaaA_PaaC; cl01346 114615006644 phenylacetate-CoA oxygenase, PaaG subunit; Region: PA_CoA_Oxy1; TIGR02156 114615006645 Phenylacetic acid degradation B; Region: PaaB; cl01371 114615006646 Phenylacetic acid catabolic protein; Region: PaaA_PaaC; cl01346 114615006647 Domain of unknown function DUF59; Region: DUF59; cl00941 114615006648 phenylacetate-CoA oxygenase, PaaJ subunit; Region: PA_CoA_Oxy4; TIGR02159 114615006649 phenylacetate-CoA oxygenase/reductase, PaaK subunit; Region: PA_CoA_Oxy5; TIGR02160 114615006650 NAD(P) binding domain of ferredoxin reductase like phenylacetic acid (PA) degradation oxidoreductase. PA oxidoreductases of E. coli hydroxylate PA-CoA in the second step of PA degradation. Members of this group typically fuse a ferredoxin reductase-...; Region: PA_degradation_oxidoreductase_like; cd06214 114615006651 FAD binding pocket [chemical binding]; other site 114615006652 FAD binding motif [chemical binding]; other site 114615006653 phosphate binding motif [ion binding]; other site 114615006654 beta-alpha-beta structure motif; other site 114615006655 NAD(p) ribose binding residues [chemical binding]; other site 114615006656 NAD binding pocket [chemical binding]; other site 114615006657 NAD(P)-pyrophosphate-nicotinamide binding residues [chemical binding]; other site 114615006658 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 114615006659 catalytic loop [active] 114615006660 iron binding site [ion binding]; other site 114615006661 Acyl-protein synthetase, LuxE; Region: LuxE; cl10450 114615006662 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 114615006663 CoenzymeA binding site [chemical binding]; other site 114615006664 subunit interaction site [polypeptide binding]; other site 114615006665 PHB binding site; other site 114615006666 putative inner membrane protein; Provisional; Region: PRK11099 114615006667 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 114615006668 OsmC-like protein; Region: OsmC; cl00767 114615006669 bacterial and archael members of the sulfite oxidase (SO) family of molybdopterin binding domains. This molybdopterin cofactor (Moco) binding domain is found in a variety of oxidoreductases, main members of this family are nitrate reductase (NR) and...; Region: arch_bact_SO_family_Moco; cd02109 114615006670 Moco binding site; other site 114615006671 metal coordination site [ion binding]; other site 114615006672 alpha-ketoglutarate transporter; Provisional; Region: PRK10406 114615006673 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 114615006674 putative substrate translocation pore; other site 114615006675 amidase; Provisional; Region: PRK07486 114615006676 GGCT-like domains, also called AIG2-like family. Gamma-glutamyl cyclotransferase (GGCT) catalyzes the formation of pyroglutamic acid (5-oxoproline) from dipeptides containing gamma-glutamyl, and is a dimeric protein. In Homo sapiens, the protein is...; Region: GGCT_like; cl11426 114615006677 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK05565 114615006678 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 114615006679 NAD(P) binding site [chemical binding]; other site 114615006680 active site 114615006681 Isocitrate/isopropylmalate dehydrogenase; Region: Iso_dh; cl00445 114615006682 Phosphoglycerate dehydrogenase and related dehydrogenases [Amino acid transport and metabolism]; Region: SerA; COG0111 114615006683 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 114615006684 allantoate amidohydrolase; Reviewed; Region: PRK09290 114615006685 M20 Peptidase beta-alanine synthase, an amidohydrolase; Region: M20_bAS; cd03884 114615006686 active site 114615006687 metal binding site [ion binding]; metal-binding site 114615006688 dimer interface [polypeptide binding]; other site 114615006689 Transcriptional regulator [Transcription]; Region: LysR; COG0583 114615006690 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 114615006691 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 114615006692 dimerization interface [polypeptide binding]; other site 114615006693 Protein of unknown function (DUF1445); Region: DUF1445; cl01790 114615006694 ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683 114615006695 Type I periplasmic ligand-binding domain of uncharacterized ABC (ATPase Binding Cassette)-type active transport systems that are predicted to be involved in transport of amino acids, peptides, or inorganic ions; Region: PBP1_ABC_ligand_binding_like_6; cd06340 114615006696 putative ligand binding site [chemical binding]; other site 114615006697 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 114615006698 TM-ABC transporter signature motif; other site 114615006699 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 114615006700 TM-ABC transporter signature motif; other site 114615006701 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411 114615006702 The Mj1267/LivG ABC transporter subfamily is involved in the transport of the hydrophobic amino acids leucine, isoleucine and valine. MJ1267 is a branched-chain amino acid transporter with 29% similarity to both the LivF and LivG components of the E...; Region: ABC_Mj1267_LivG_branched; cd03219 114615006703 Walker A/P-loop; other site 114615006704 ATP binding site [chemical binding]; other site 114615006705 Q-loop/lid; other site 114615006706 ABC transporter signature motif; other site 114615006707 Walker B; other site 114615006708 D-loop; other site 114615006709 H-loop/switch region; other site 114615006710 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410 114615006711 LivF (TM1139) is part of the LIV-I bacterial ABC-type two-component transport system that imports neutral, branched-chain amino acids. The E. coli branched-chain amino acid transporter comprises a heterodimer of ABC transporters (LivF and LivG), a...; Region: ABC_TM1139_LivF_branched; cd03224 114615006712 Walker A/P-loop; other site 114615006713 ATP binding site [chemical binding]; other site 114615006714 Q-loop/lid; other site 114615006715 ABC transporter signature motif; other site 114615006716 Walker B; other site 114615006717 D-loop; other site 114615006718 H-loop/switch region; other site 114615006719 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 114615006720 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cl00427 114615006721 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261 114615006722 dimer interface [polypeptide binding]; other site 114615006723 ABC-ATPase subunit interface; other site 114615006724 putative PBP binding loops; other site 114615006725 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261 114615006726 putative PBP binding loops; other site 114615006727 ABC-ATPase subunit interface; other site 114615006728 Spermidine/putrescine-binding periplasmic protein [Amino acid transport and metabolism]; Region: PotD; COG0687 114615006729 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 114615006730 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 114615006731 Walker A/P-loop; other site 114615006732 ATP binding site [chemical binding]; other site 114615006733 Q-loop/lid; other site 114615006734 ABC transporter signature motif; other site 114615006735 Walker B; other site 114615006736 D-loop; other site 114615006737 H-loop/switch region; other site 114615006738 TOBE domain; Region: TOBE_2; cl01440 114615006739 Class II Aldolase and Adducin head (N-terminal) domain. Aldolases are ubiquitous enzymes catalyzing central steps of carbohydrate metabolism. Based on enzymatic mechanisms, this superfamily has been divided into two distinct classes (Class I and II)...; Region: Aldolase_II; cl00214 114615006740 intersubunit interface [polypeptide binding]; other site 114615006741 active site 114615006742 Zn2+ binding site [ion binding]; other site 114615006743 fructose-bisphosphate aldolase; Region: PLN02858 114615006744 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 114615006745 Hydroxypyruvate isomerase [Carbohydrate transport and metabolism]; Region: Hfi; COG3622 114615006746 Protein of unknown function, DUF1537; Region: DUF1537; cl01345 114615006747 Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices connected by an extended linker. The...; Region: HAMP; cl01054 114615006748 Taxis toward Aspartate and Related amino acids and Homologs (TarH). The Tar chemoreceptor of Escherichia coli mediates attractant responses to aspartate, maltose, and phenol, repellent responses to Ni2+ and Co2+, and thermoresponses. These...; Region: TarH; cl00144 114615006749 Signal transduction histidine kinase involved in nitrogen fixation and metabolism regulation [Signal transduction mechanisms]; Region: NtrY; COG5000 114615006750 Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices connected by an extended linker. The...; Region: HAMP; cl01054 114615006751 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 114615006752 Taxis toward Aspartate and Related amino acids and Homologs (TarH). The Tar chemoreceptor of Escherichia coli mediates attractant responses to aspartate, maltose, and phenol, repellent responses to Ni2+ and Co2+, and thermoresponses. These...; Region: TarH; cl00144 114615006753 Four helix bundle sensory module for signal transduction; Region: 4HB_MCP_2; pfam12729 114615006754 Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840 114615006755 Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices connected by an extended linker. The...; Region: HAMP; cl01054 114615006756 Taxis toward Aspartate and Related amino acids and Homologs (TarH). The Tar chemoreceptor of Escherichia coli mediates attractant responses to aspartate, maltose, and phenol, repellent responses to Ni2+ and Co2+, and thermoresponses. These...; Region: TarH; cl00144 114615006757 Cache domain; Region: Cache_2; cl07034 114615006758 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4564 114615006759 Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices connected by an extended linker. The...; Region: HAMP; cl01054 114615006760 Taxis toward Aspartate and Related amino acids and Homologs (TarH). The Tar chemoreceptor of Escherichia coli mediates attractant responses to aspartate, maltose, and phenol, repellent responses to Ni2+ and Co2+, and thermoresponses. These...; Region: TarH; cl00144 114615006761 Type I periplasmic binding domain of uncharacterized extracellular ligand-binding proteins; Region: PBP1_STKc_like; cd06326 114615006762 putative ligand binding site [chemical binding]; other site 114615006763 Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices connected by an extended linker. The...; Region: HAMP; cl01054 114615006764 Taxis toward Aspartate and Related amino acids and Homologs (TarH). The Tar chemoreceptor of Escherichia coli mediates attractant responses to aspartate, maltose, and phenol, repellent responses to Ni2+ and Co2+, and thermoresponses. These...; Region: TarH; cl00144 114615006765 CHASE3 domain; Region: CHASE3; cl05000 114615006766 Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices connected by an extended linker. The...; Region: HAMP; cl01054 114615006767 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 114615006768 Taxis toward Aspartate and Related amino acids and Homologs (TarH). The Tar chemoreceptor of Escherichia coli mediates attractant responses to aspartate, maltose, and phenol, repellent responses to Ni2+ and Co2+, and thermoresponses. These...; Region: TarH; cl00144 114615006769 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 114615006770 PAS fold; Region: PAS_3; pfam08447 114615006771 putative active site [active] 114615006772 heme pocket [chemical binding]; other site 114615006773 Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices connected by an extended linker. The...; Region: HAMP; cl01054 114615006774 Taxis toward Aspartate and Related amino acids and Homologs (TarH). The Tar chemoreceptor of Escherichia coli mediates attractant responses to aspartate, maltose, and phenol, repellent responses to Ni2+ and Co2+, and thermoresponses. These...; Region: TarH; cl00144 114615006775 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 114615006776 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of...; Region: DnaJ; cl02542 114615006777 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi...; Region: TPR; cd00189 114615006778 binding surface 114615006779 TPR motif; other site 114615006780 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi...; Region: TPR; cd00189 114615006781 binding surface 114615006782 TPR motif; other site 114615006783 acetyl-CoA acetyltransferase; Validated; Region: PRK08257 114615006784 Thiolase domain associated with sterol carrier protein (SCP)-x isoform and related proteins; SCP-2 has multiple roles in intracellular lipid circulation and metabolism. The N-terminal presequence in the SCP-x isoform represents a peroxisomal 3-ketacyl-; Region: SCP-x_thiolase; cd00829 114615006785 active site 114615006786 putative S-transferase; Provisional; Region: PRK11752 114615006787 GST_N family, Ure2p-like subfamily; composed of the Saccharomyces cerevisiae Ure2p and related GSTs. Ure2p is a regulator for nitrogen catabolism in yeast. It represses the expression of several gene products involved in the use of poor nitrogen...; Region: GST_N_Ure2p_like; cd03048 114615006788 C-terminal domain interface [polypeptide binding]; other site 114615006789 GSH binding site (G-site) [chemical binding]; other site 114615006790 dimer interface [polypeptide binding]; other site 114615006791 C-terminal, alpha helical domain of Escherichia coli Yghu Glutathione S-transferases and related uncharacterized proteins; Region: GST_C_YghU_like; cd10292 114615006792 dimer interface [polypeptide binding]; other site 114615006793 N-terminal domain interface [polypeptide binding]; other site 114615006794 active site 114615006795 Flavin Reductases; Region: FlaRed; cl00801 114615006796 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 114615006797 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 114615006798 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 114615006799 NAD(P) binding site [chemical binding]; other site 114615006800 active site 114615006801 enoyl-CoA hydratase; Provisional; Region: PRK05981 114615006802 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase...; Region: crotonase-like; cd06558 114615006803 substrate binding site [chemical binding]; other site 114615006804 oxyanion hole (OAH) forming residues; other site 114615006805 trimer interface [polypeptide binding]; other site 114615006806 Acyl-CoA dehydrogenase (ACAD) 10 and 11, N-terminal domain, and similar proteins. This subfamily is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: ACAD10_11_like; cd05154 114615006807 Phosphotransferase enzyme family; Region: APH; pfam01636 114615006808 putative active site [active] 114615006809 putative substrate binding site [chemical binding]; other site 114615006810 ATP binding site [chemical binding]; other site 114615006811 enoyl-CoA hydratase; Provisional; Region: PRK06494 114615006812 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase...; Region: crotonase-like; cd06558 114615006813 substrate binding site [chemical binding]; other site 114615006814 oxyanion hole (OAH) forming residues; other site 114615006815 trimer interface [polypeptide binding]; other site 114615006816 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 114615006817 Acyl-CoA dehydrogenase, N-terminal domain; Region: Acyl-CoA_dh_N; pfam02771 114615006818 Acyl-CoA dehydrogenase; Region: ACAD; cd00567 114615006819 active site 114615006820 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK06187 114615006821 Acyl-protein synthetase, LuxE; Region: LuxE; cl10450 114615006822 Trans-2-enoyl-CoA reductase (TER) and 2,4-dienoyl-CoA reductase (DECR), atypical (a) SDR; Region: TER_DECR_SDR_a; cd05369 114615006823 short chain dehydrogenase; Provisional; Region: PRK07677 114615006824 NAD(P) binding site [chemical binding]; other site 114615006825 substrate binding site [chemical binding]; other site 114615006826 homotetramer interface [polypeptide binding]; other site 114615006827 active site 114615006828 homodimer interface [polypeptide binding]; other site 114615006829 enoyl-CoA hydratase; Provisional; Region: PRK07509 114615006830 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase...; Region: crotonase-like; cd06558 114615006831 substrate binding site [chemical binding]; other site 114615006832 oxyanion hole (OAH) forming residues; other site 114615006833 trimer interface [polypeptide binding]; other site 114615006834 long-chain-fatty-acid--CoA ligase; Provisional; Region: PRK12406 114615006835 Acyl-protein synthetase, LuxE; Region: LuxE; cl10450 114615006836 Phosphoenolpyruvate carboxylase [Carbohydrate transport and metabolism; Energy production and conversion]; Region: COG1892; cl14656 114615006837 Phosphoenolpyruvate carboxylase [Energy production and conversion]; Region: Ppc; COG2352 114615006838 Gluconolactonase [Carbohydrate transport and metabolism]; Region: COG3386 114615006839 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 114615006840 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 114615006841 NAD(P) binding site [chemical binding]; other site 114615006842 active site 114615006843 thiolase; Provisional; Region: PRK06158 114615006844 Thiolase domain associated with sterol carrier protein (SCP)-x isoform and related proteins; SCP-2 has multiple roles in intracellular lipid circulation and metabolism. The N-terminal presequence in the SCP-x isoform represents a peroxisomal 3-ketacyl-; Region: SCP-x_thiolase; cd00829 114615006845 active site 114615006846 Rubredoxin-like zinc ribbon domain (DUF35_N); Region: DUF35_N; pfam12172 114615006847 DUF35 OB-fold domain; Region: DUF35; pfam01796 114615006848 amidase; Provisional; Region: PRK07056 114615006849 GGCT-like domains, also called AIG2-like family. Gamma-glutamyl cyclotransferase (GGCT) catalyzes the formation of pyroglutamic acid (5-oxoproline) from dipeptides containing gamma-glutamyl, and is a dimeric protein. In Homo sapiens, the protein is...; Region: GGCT_like; cl11426 114615006850 Transglycosylase; Region: Transgly; cl07896 114615006851 2OG-Fe(II) oxygenase superfamily; Region: 2OG-FeII_Oxy; cl01206 114615006852 2OG-Fe(II) oxygenase superfamily; Region: 2OG-FeII_Oxy; cl01206 114615006853 hypothetical protein; Provisional; Region: PRK08266 114615006854 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 114615006855 PYR/PP interface [polypeptide binding]; other site 114615006856 dimer interface [polypeptide binding]; other site 114615006857 TPP binding site [chemical binding]; other site 114615006858 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 114615006859 Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin...; Region: TPP_enzymes; cl01629 114615006860 TPP-binding site [chemical binding]; other site 114615006861 2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179 114615006862 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; cl11421 114615006863 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 114615006864 Human aldehyde dehydrogenase family 8 member A1-like; Region: ALDH_F8_HMSADH; cd07093 114615006865 NAD binding site [chemical binding]; other site 114615006866 catalytic residues [active] 114615006867 5-carboxymethyl-2-hydroxymuconate isomerase (CHMI) is a trimeric enzyme catalyzing the isomerization of the unsaturated ketone 5-(carboxymethyl)-2-hydroxymuconate to 5-(carboxymethyl)-2-oxo-3-hexene-1,6-dionate. This is one step in the...; Region: CHMI; cd00580 114615006868 putative substrate binding pocket [chemical binding]; other site 114615006869 trimer interface [polypeptide binding]; other site 114615006870 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; cl11421 114615006871 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 114615006872 Transcriptional regulators [Transcription]; Region: MarR; COG1846 114615006873 Malate/L-lactate dehydrogenase; Region: Ldh_2; cl00900 114615006874 2,4-dihydroxyhept-2-ene-1,7-dioic acid aldolase [Carbohydrate transport and metabolism]; Region: HpcH; COG3836 114615006875 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl09155 114615006876 galactarate dehydratase; Region: galactar-dH20; TIGR03248 114615006877 SAF domain; Region: SAF; cl00555 114615006878 SAF domain; Region: SAF; cl00555 114615006879 Bacterial transglutaminase-like N-terminal region; Region: Bact_transglu_N; pfam08379 114615006880 Transglutaminase-like superfamily; Region: Transglut_core; cl10469 114615006881 Putative amidoligase enzyme (DUF2126); Region: DUF2126; pfam09899 114615006882 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4196 114615006883 Uncharacterized conserved protein [Function unknown]; Region: COG2308 114615006884 Domain of unknown function (DUF404); Region: DUF404; pfam04169 114615006885 Domain of unknown function (DUF407); Region: DUF407; pfam04174 114615006886 Bacterial domain of unknown function (DUF403); Region: DUF403; cl00980 114615006887 Bacterial transglutaminase-like N-terminal region; Region: Bact_transglu_N; pfam08379 114615006888 Transglutaminase-like superfamily; Region: Transglut_core; cl10469 114615006889 SMP-30/Gluconolaconase/LRE-like region; Region: SGL; pfam08450 114615006890 Glucose/sorbosone dehydrogenases [Carbohydrate transport and metabolism]; Region: COG2133 114615006891 Glucose / Sorbosone dehydrogenase; Region: GSDH; pfam07995 114615006892 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl09110 114615006893 transmembrane helices; other site 114615006894 Uncharacterized protein related to deoxyribodipyrimidine photolyase [General function prediction only]; Region: COG3046 114615006895 Deoxyribodipyrimidine photo-lyase-related protein; Region: DPRP; pfam04244 114615006896 FAD binding domain of DNA photolyase; Region: FAD_binding_7; pfam03441 114615006897 RNA polymerase sigma factor; Provisional; Region: PRK12514 114615006898 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 114615006899 Transcriptional activator [Transcription]; Region: ChrR; COG3806 114615006900 Cupin domain; Region: Cupin_2; cl09118 114615006901 RNA polymerase sigma factor RpoE; Provisional; Region: PRK09652 114615006902 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 114615006903 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial...; Region: Sigma70_r4; cd06171 114615006904 DNA binding residues [nucleotide binding] 114615006905 GTP cyclohydrolase I (GTP-CH-I) catalyzes the conversion of GTP into dihydroneopterin triphosphate. The enzyme product is the precursor of tetrahydrofolate in eubacteria, fungi, and plants and of the folate analogs in methanogenic bacteria. In...; Region: GTP_cyclohydro1; cd00642 114615006906 homodecamer interface [polypeptide binding]; other site 114615006907 GTP cyclohydrolase I; Provisional; Region: PLN03044 114615006908 active site 114615006909 putative catalytic site residues [active] 114615006910 zinc binding site [ion binding]; other site 114615006911 GTP-CH-I/GFRP interaction surface; other site 114615006912 omega amino acid--pyruvate transaminase; Provisional; Region: PRK13360 114615006913 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase...; Region: OAT_like; cd00610 114615006914 inhibitor-cofactor binding pocket; inhibition site 114615006915 pyridoxal 5'-phosphate binding site [chemical binding]; other site 114615006916 catalytic residue [active] 114615006917 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 114615006918 DNA-binding site [nucleotide binding]; DNA binding site 114615006919 Transcriptional regulators [Transcription]; Region: FadR; COG2186 114615006920 FCD domain; Region: FCD; cl11656 114615006921 Acyl-coenzyme A:6-aminopenicillanic acid acyl-transferase; Region: AAT; pfam03417 114615006922 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_16; cd08502 114615006923 Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496 114615006924 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 114615006925 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cl00427 114615006926 nickel ABC transporter, permease subunit NikC; Region: nickel_nikC; TIGR02790 114615006927 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261 114615006928 dimer interface [polypeptide binding]; other site 114615006929 conserved gate region; other site 114615006930 putative PBP binding loops; other site 114615006931 ABC-ATPase subunit interface; other site 114615006932 ATPase components of various ABC-type transport systems, contain duplicated ATPase [General function prediction only]; Region: COG1123 114615006933 The ABC transporter subfamily specific for the transport of dipeptides, oligopeptides (OppD), and nickel (NikDE). The NikABCDE system of E. coli belongs to this family and is composed of the periplasmic binding protein NikA, two integral membrane...; Region: ABC_NikE_OppD_transporters; cd03257 114615006934 Walker A/P-loop; other site 114615006935 ATP binding site [chemical binding]; other site 114615006936 Q-loop/lid; other site 114615006937 ABC transporter signature motif; other site 114615006938 Walker B; other site 114615006939 D-loop; other site 114615006940 H-loop/switch region; other site 114615006941 The ABC transporter subfamily specific for the transport of dipeptides, oligopeptides (OppD), and nickel (NikDE). The NikABCDE system of E. coli belongs to this family and is composed of the periplasmic binding protein NikA, two integral membrane...; Region: ABC_NikE_OppD_transporters; cd03257 114615006942 Walker A/P-loop; other site 114615006943 ATP binding site [chemical binding]; other site 114615006944 Q-loop/lid; other site 114615006945 ABC transporter signature motif; other site 114615006946 Walker B; other site 114615006947 D-loop; other site 114615006948 H-loop/switch region; other site 114615006949 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 114615006950 Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices connected by an extended linker. The...; Region: HAMP; cl01054 114615006951 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 114615006952 Taxis toward Aspartate and Related amino acids and Homologs (TarH). The Tar chemoreceptor of Escherichia coli mediates attractant responses to aspartate, maltose, and phenol, repellent responses to Ni2+ and Co2+, and thermoresponses. These...; Region: TarH; cl00144 114615006953 B12 binding domain (B12-BD). Most of the members bind different cobalamid derivates, like B12 (adenosylcobamide) or methylcobalamin or methyl-Co(III) 5-hydroxybenzimidazolylcobamide. This domain is found in several enzymes, such as glutamate mutase...; Region: B12-binding_like; cl00293 114615006954 Radical SAM; Region: Elp3; smart00729 114615006955 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster...; Region: Radical_SAM; cl15259 114615006956 Predicted exporters of the RND superfamily [General function prediction only]; Region: COG1033 114615006957 Trans-Isoprenyl Diphosphate Synthases, head-to-head; Region: Trans_IPPS_HH; cd00683 114615006958 active site lid residues [active] 114615006959 substrate binding pocket [chemical binding]; other site 114615006960 catalytic residues [active] 114615006961 substrate-Mg2+ binding site; other site 114615006962 aspartate-rich region 1; other site 114615006963 aspartate-rich region 2; other site 114615006964 Trans-Isoprenyl Diphosphate Synthases, head-to-head; Region: Trans_IPPS_HH; cd00683 114615006965 active site lid residues [active] 114615006966 substrate binding pocket [chemical binding]; other site 114615006967 catalytic residues [active] 114615006968 substrate-Mg2+ binding site; other site 114615006969 aspartate-rich region 1; other site 114615006970 aspartate-rich region 2; other site 114615006971 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 114615006972 Flavin containing amine oxidoreductase; Region: Amino_oxidase; pfam01593 114615006973 Phosphorylase superfamily; Region: PNP_UDP_1; cl00303 114615006974 hopanoid biosynthesis associated radical SAM protein HpnH; Region: HpnH; TIGR03470 114615006975 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster...; Region: Radical_SAM; cd01335 114615006976 FeS/SAM binding site; other site 114615006977 Domain of unknown function (DUF3463); Region: DUF3463; pfam11946 114615006978 LytB protein; Region: LYTB; cl00507 114615006979 (E)-4-hydroxy-3-methyl-but-2-enyl pyrophosphate reductase (IPP and DMAPP forming); Region: ispH_lytB; TIGR00216 114615006980 hopanoid biosynthesis associated RND transporter like protein HpnN; Region: HpnN; TIGR03480 114615006981 Uncharacterized protein conserved in bacteria (DUF2147); Region: DUF2147; cl01951 114615006982 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase...; Region: OAT_like; cd00610 114615006983 Ornithine/acetylornithine aminotransferase [Amino acid transport and metabolism]; Region: ArgD; COG4992 114615006984 inhibitor-cofactor binding pocket; inhibition site 114615006985 pyridoxal 5'-phosphate binding site [chemical binding]; other site 114615006986 catalytic residue [active] 114615006987 Predicted transmembrane transcriptional regulator (anti-sigma factor) [Transcription]; Region: COG5662 114615006988 mycothiol system anti-sigma-R factor; Region: antisig_RsrA; cl11829 114615006989 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 114615006990 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial...; Region: Sigma70_r4; cd06171 114615006991 DNA binding residues [nucleotide binding] 114615006992 Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; cl11412 114615006993 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 114615006994 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 114615006995 active site 114615006996 metal binding site [ion binding]; metal-binding site 114615006997 Predicted O-acyltransferase [General function prediction only]; Region: COG3274; cl00792 114615006998 Acyltransferase family; Region: Acyl_transf_3; pfam01757 114615006999 choline dehydrogenase; Validated; Region: PRK02106 114615007000 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 114615007001 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 114615007002 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 114615007003 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 114615007004 M20 Peptidase Aminoacylase 1 subfamily; Region: M20_Acy1_like1; cd05666 114615007005 metal binding site [ion binding]; metal-binding site 114615007006 putative dimer interface [polypeptide binding]; other site 114615007007 probable DNA metabolism protein; Region: SAM_7_link_chp; TIGR03915 114615007008 Family 4 Uracil-DNA glycosylase (UDG), found exclusively in thermophilic organisms; Region: UDG_F4_TTUDGA_like; cd10030 114615007009 Fe-S cluster binding site [ion binding]; other site 114615007010 active site 114615007011 putative DNA modification/repair radical SAM protein; Region: rSAM_link_UDG; TIGR03916 114615007012 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster...; Region: Radical_SAM; cd01335 114615007013 FeS/SAM binding site; other site 114615007014 Cell division inhibitor SulA; Region: SulA; cl01880 114615007015 DNA Polymerase Y-family; Region: PolY_like; cd03468 114615007016 active site 114615007017 DNA binding site [nucleotide binding] 114615007018 DNA polymerase alpha chain like domain; Region: POLIIIAc; smart00481 114615007019 DNA polymerase III PolC; Validated; Region: polC; PRK00448 114615007020 Bacterial DNA polymerase III alpha subunit; Region: DNA_pol3_alpha; pfam07733 114615007021 DNA polymerase III, alpha subunit (gram-positive type) [DNA replication, recombination, and repair]; Region: PolC; COG2176 114615007022 error-prone DNA polymerase; Validated; Region: dnaE2; PRK05672 114615007023 DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli...; Region: DnaE_OBF; cd04485 114615007024 generic binding surface II; other site 114615007025 generic binding surface I; other site 114615007026 Transposase IS200 like; Region: Y1_Tnp; cl00848 114615007027 urea carboxylase; Region: urea_carbox; TIGR02712 114615007028 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase...; Region: biotinyl_domain; cd06850 114615007029 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 114615007030 Outer membrane efflux protein; Region: OEP; pfam02321 114615007031 Putative silver efflux pump [Inorganic ion transport and metabolism]; Region: COG3696 114615007032 LivF (TM1139) is part of the LIV-I bacterial ABC-type two-component transport system that imports neutral, branched-chain amino acids. The E. coli branched-chain amino acid transporter comprises a heterodimer of ABC transporters (LivF and LivG), a...; Region: ABC_TM1139_LivF_branched; cd03224 114615007033 urea ABC transporter, ATP-binding protein UrtE; Region: urea_trans_UrtE; TIGR03410 114615007034 Walker A/P-loop; other site 114615007035 ATP binding site [chemical binding]; other site 114615007036 Q-loop/lid; other site 114615007037 ABC transporter signature motif; other site 114615007038 Walker B; other site 114615007039 D-loop; other site 114615007040 H-loop/switch region; other site 114615007041 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 114615007042 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 114615007043 TM-ABC transporter signature motif; other site 114615007044 urea ABC transporter, ATP-binding protein UrtD; Region: urea_trans_UrtD; TIGR03411 114615007045 The Mj1267/LivG ABC transporter subfamily is involved in the transport of the hydrophobic amino acids leucine, isoleucine and valine. MJ1267 is a branched-chain amino acid transporter with 29% similarity to both the LivF and LivG components of the E...; Region: ABC_Mj1267_LivG_branched; cd03219 114615007046 Walker A/P-loop; other site 114615007047 ATP binding site [chemical binding]; other site 114615007048 Q-loop/lid; other site 114615007049 ABC transporter signature motif; other site 114615007050 Walker B; other site 114615007051 D-loop; other site 114615007052 H-loop/switch region; other site 114615007053 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 114615007054 TM-ABC transporter signature motif; other site 114615007055 ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683 114615007056 Type I periplasmic-binding protein of the nitrile hydratase (NHase) system that selectively converts nitriles to corresponding amides; Region: PBP1_NHase; cd06358 114615007057 putative ligand binding site [chemical binding]; other site 114615007058 Predicted amidohydrolase [General function prediction only]; Region: COG0388 114615007059 Uncharacterized subgroup of the nitrilase superfamily (putative class 13 nitrilases); Region: nitrilase_2; cd07580 114615007060 putative active site [active] 114615007061 catalytic triad [active] 114615007062 putative dimer interface [polypeptide binding]; other site 114615007063 Response regulator with putative antiterminator output domain [Signal transduction mechanisms]; Region: AmiR; COG3707 114615007064 ANTAR domain; Region: ANTAR; cl04297 114615007065 ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683 114615007066 Periplasmic binding domain of amidase (AmiC) that belongs to the type I periplasmic binding fold protein family; Region: PBP1_AmiC; cd06357 114615007067 ligand binding site [chemical binding]; other site 114615007068 regulator interaction site; other site 114615007069 Domain of unknown function DUF20; Region: UPF0118; cl00465 114615007070 Predicted metal-dependent hydrolase of the TIM-barrel fold [General function prediction only]; Region: COG3618 114615007071 2-pyrone-4,6-dicarboxylic acid (PDC) hydrolase hydrolyzes PDC to yield 4-oxalomesaconic acid (OMA) or its tautomer, 4-carboxy-2-hydroxymuconic acid (CHM). This reaction is part of the protocatechuate (PCA) 4,5-cleavage pathway. PCA is one of the most...; Region: PDC_hydrolase; cd01311 114615007072 active site 114615007073 type I secretion outer membrane protein, TolC family; Region: type_I_sec_TolC; TIGR01844 114615007074 Outer membrane efflux protein; Region: OEP; pfam02321 114615007075 Outer membrane efflux protein; Region: OEP; pfam02321 114615007076 enoyl-CoA hydratase; Provisional; Region: PRK05862 114615007077 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase...; Region: crotonase-like; cd06558 114615007078 substrate binding site [chemical binding]; other site 114615007079 oxyanion hole (OAH) forming residues; other site 114615007080 trimer interface [polypeptide binding]; other site 114615007081 RNA polymerase sigma factor; Provisional; Region: PRK12512 114615007082 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 114615007083 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl15258 114615007084 Protein of unknown function (DUF1109); Region: DUF1109; cl02071 114615007085 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5330 114615007086 Uncharacterized protein conserved in bacteria (DUF2336); Region: DUF2336; pfam10098 114615007087 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 114615007088 metal binding site [ion binding]; metal-binding site 114615007089 active site 114615007090 I-site; other site 114615007091 RNA polymerase sigma factor; Provisional; Region: PRK12515 114615007092 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 114615007093 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial...; Region: Sigma70_r4; cd06171 114615007094 DNA binding residues [nucleotide binding] 114615007095 TIGR03809 family protein; Region: TIGR03809 114615007096 twin-arg-translocated uncharacterized repeat protein; Region: RR_plus_rpt_1; TIGR03808 114615007097 putative cofactor-binding repeat; Region: RR_fam_repeat; TIGR03807 114615007098 Pyroglutamyl peptidase (PGP) type I, also known as pyrrolidone carboxyl peptidase (pcp) type I: Enzymes responsible for cleaving pyroglutamate (pGlu) from the N-terminal end of specialized proteins. The N-terminal pGlu protects these proteins from...; Region: Peptidase_C15; cd00501 114615007099 putative substrate binding pocket [chemical binding]; other site 114615007100 AC domain interface; other site 114615007101 catalytic triad [active] 114615007102 AB domain interface; other site 114615007103 interchain disulfide; other site 114615007104 membrane ATPase/protein kinase; Provisional; Region: PRK09435 114615007105 The function of this protein family is unkown. The protein sequences are similar to the ArgK protein in E. coli. ArgK protein is a membrane ATPase which is required for transporting arginine, ornithine and lysine into the cells by the arginine and...; Region: ArgK-like; cd03114 114615007106 Walker A; other site 114615007107 Ras-like GTPase superfamily. The Ras-like superfamily of small GTPases consists of several families with an extremely high degree of structural and functional similarity. The Ras superfamily is divided into at least four families in eukaryotes: the Ras...; Region: Ras_like_GTPase; cl10444 114615007108 G4 box; other site 114615007109 G5 box; other site 114615007110 Protein of unknown function (DUF3298); Region: DUF3298; pfam11738 114615007111 methylmalonyl-CoA mutase; Reviewed; Region: PRK09426 114615007112 Coenzyme B12-dependent-methylmalonyl coenzyme A (CoA) mutase (MCM) family, Alpha subunit-like subfamily; contains proteins similar to the alpha subunit of Propionbacterium shermanni MCM, as well as human and E. coli MCM. Members of this subfamily...; Region: MM_CoA_mutase_alpha_like; cd03679 114615007113 active site 114615007114 substrate binding site [chemical binding]; other site 114615007115 coenzyme B12 binding site [chemical binding]; other site 114615007116 methylmalonyl CoA mutase B12 binding domain. This domain binds to B12 (adenosylcobamide), which initiates the conversion of succinyl CoA and methylmalonyl CoA by forming an adenosyl radical, which then undergoes a rearrangement exchanging a hydrogen...; Region: MM_CoA_mut_B12_BD; cd02071 114615007117 B12 binding site [chemical binding]; other site 114615007118 cobalt ligand [ion binding]; other site 114615007119 Glutathione-dependent formaldehyde-activating enzyme; Region: GFA; cl01553 114615007120 methylmalonyl-CoA mutase, heterodimeric type, beta chain; Region: mmCoA_mut_beta; TIGR00642 114615007121 Coenzyme B12-dependent-methylmalonyl coenzyme A (CoA) mutase (MCM) family, Beta subunit-like subfamily; contains bacterial proteins similar to the beta subunit of MCMs from Propionbacterium shermanni and Streptomyces cinnamonensis, which are alpha/beta...; Region: MM_CoA_mutase_beta; cd03677 114615007122 heterodimer interface [polypeptide binding]; other site 114615007123 substrate interaction site [chemical binding]; other site 114615007124 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase (HPPK). Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and amino acids as well as formyl-tRNA. Mammalian cells are able to utilize pre-formed folates after...; Region: HPPK; cd00483 114615007125 catalytic center binding site [active] 114615007126 ATP binding site [chemical binding]; other site 114615007127 Tunnelling fold (T-fold). The five known T-folds are found in five different enzymes with different functions: dihydroneopterin-triphosphate epimerase (DHNTPE), dihydroneopterin aldolase (DHNA) , GTP cyclohydrolase I (GTPCH-1), 6-pyrovoyl...; Region: TFold; cl00263 114615007128 active site 114615007129 DHPS subgroup of Pterin binding enzymes. DHPS (dihydropteroate synthase), a functional homodimer, catalyzes the condensation of p-aminobenzoic acid (pABA) in the de novo biosynthesis of folate, which is an essential cofactor in both nucleic acid and...; Region: DHPS; cd00739 114615007130 dihydropteroate synthase; Region: DHPS; TIGR01496 114615007131 substrate binding pocket [chemical binding]; other site 114615007132 dimer interface [polypeptide binding]; other site 114615007133 inhibitor binding site; inhibition site 114615007134 Nucleotidyltransferase (NT) domain of DNA polymerase beta and similar proteins; Region: NT_Pol-beta-like; cl11966 114615007135 Bacterial protein of unknown function (DUF853); Region: DUF853; pfam05872 114615007136 Acetylornithine deacetylase/Succinyl-diaminopimelate desuccinylase and related deacylases [Amino acid transport and metabolism]; Region: ArgE; COG0624 114615007137 Uncharacterized M20 Dipeptidases; Region: M20_dipept_like_3; cd05680 114615007138 metal binding site [ion binding]; metal-binding site 114615007139 putative dimer interface [polypeptide binding]; other site 114615007140 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 114615007141 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 114615007142 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 114615007143 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 114615007144 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 114615007145 Predicted nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG0702 114615007146 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 114615007147 NAD(P) binding site [chemical binding]; other site 114615007148 active site 114615007149 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 114615007150 metal binding site [ion binding]; metal-binding site 114615007151 active site 114615007152 I-site; other site 114615007153 Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]; Region: DegQ; COG0265 114615007154 Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic...; Region: Tryp_SPc; cl00149 114615007155 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind C-...; Region: PDZ_serine_protease; cd00987 114615007156 Chaperonin 10 Kd subunit (cpn10 or GroES); Cpn10 cooperates with chaperonin 60 (cpn60 or GroEL), an ATPase, to assist the folding and assembly of proteins and is found in eubacterial cytosol, as well as in the matrix of mitochondria and chloroplasts...; Region: cpn10; cd00320 114615007157 oligomerisation interface [polypeptide binding]; other site 114615007158 mobile loop; other site 114615007159 roof hairpin; other site 114615007160 chaperonin GroEL; Reviewed; Region: groEL; PRK12849 114615007161 GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344 114615007162 ring oligomerisation interface [polypeptide binding]; other site 114615007163 ATP/Mg binding site [chemical binding]; other site 114615007164 stacking interactions; other site 114615007165 hinge regions; other site 114615007166 Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071 114615007167 Alpha-crystallin domain (ACD) found in Escherichia coli inclusion body-associated proteins IbpA and IbpB, and similar proteins. IbpA and IbpB are 16 kDa small heat shock proteins (sHsps). sHsps are molecular chaperones that suppress protein...; Region: ACD_IbpA-B_like; cd06470 114615007168 putative dimer interface [polypeptide binding]; other site 114615007169 Class II Aldolase and Adducin head (N-terminal) domain. Aldolases are ubiquitous enzymes catalyzing central steps of carbohydrate metabolism. Based on enzymatic mechanisms, this superfamily has been divided into two distinct classes (Class I and II)...; Region: Aldolase_II; cl00214 114615007170 intersubunit interface [polypeptide binding]; other site 114615007171 active site 114615007172 Zn2+ binding site [ion binding]; other site 114615007173 ROS/MUCR transcriptional regulator protein; Region: ROS_MUCR; cl11561 114615007174 Fe-S metabolism associated domain; Region: SufE; cl00951 114615007175 PAS domain S-box; Region: sensory_box; TIGR00229 114615007176 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459 114615007177 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via trans-...; Region: HisKA; cd00082 114615007178 dimer interface [polypeptide binding]; other site 114615007179 phosphorylation site [posttranslational modification] 114615007180 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 114615007181 ATP binding site [chemical binding]; other site 114615007182 Mg2+ binding site [ion binding]; other site 114615007183 G-X-G motif; other site 114615007184 His/Ser-rich radical SAM pair-associated protein; Region: His_Ser_Rich; TIGR03979 114615007185 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 114615007186 Protein of unknown function (DUF1491); Region: DUF1491; cl11568 114615007187 succinate CoA transferases; Region: YgfH_subfam; TIGR03458 114615007188 Acetyl-CoA hydrolase/transferase N-terminal domain; Region: AcetylCoA_hydro; pfam02550 114615007189 CYTH-like Clostridium thermocellum TTM-like subgroup 1; Region: CYTH-like_CthTTM-like_1; cd07891 114615007190 putative active site [active] 114615007191 putative metal binding residues [ion binding]; other site 114615007192 signature motif; other site 114615007193 putative dimer interface [polypeptide binding]; other site 114615007194 putative phosphate binding site [ion binding]; other site 114615007195 Protein of unknown function (DUF1254); Region: DUF1254; cl02257 114615007196 Protein of unknown function (DUF1214); Region: DUF1214; cl08447 114615007197 Transglycosylase; Region: Transgly; cl07896 114615007198 penicillin-binding protein, 1A family; Region: PBP_1a_fam; TIGR02074 114615007199 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01039 114615007200 Flagellin N-methylase; Region: FliB; cl00497 114615007201 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 114615007202 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 114615007203 putative substrate translocation pore; other site 114615007204 Uncharacterized conserved protein [Function unknown]; Region: COG3743 114615007205 Uncharacterized conserved protein [Function unknown]; Region: COG3743 114615007206 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 114615007207 ligand binding site [chemical binding]; other site 114615007208 Predicted exonuclease of the beta-lactamase fold involved in RNA processing [Translation, ribosomal structure and biogenesis]; Region: YSH1; COG1236 114615007209 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 114615007210 Beta-Casp domain; Region: Beta-Casp; cl12567 114615007211 thymidine phosphorylase; Provisional; Region: PRK04350 114615007212 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 114615007213 Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591 114615007214 Pyrimidine nucleoside phosphorylase C-terminal domain; Region: PYNP_C; cl06734 114615007215 Flp/Fap pilin component; Region: Flp_Fap; cl01585 114615007216 Ku protein, prokaryotic; Region: Ku_bact; TIGR02772 114615007217 Ku-core domain, Ku-like subfamily; composed of prokaryotic homologs of the eukaryotic DNA binding protein Ku. The alignment includes the core domain shared by the prokaryotic YkoV-like proteins and the eukaryotic Ku70 and Ku80. The prokaryotic Ku...; Region: KU_like; cd00789 114615007218 putative DNA binding site [nucleotide binding]; other site 114615007219 putative homodimer interface [polypeptide binding]; other site 114615007220 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 114615007221 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156 114615007222 active site 114615007223 phosphorylation site [posttranslational modification] 114615007224 intermolecular recognition site; other site 114615007225 dimerization interface [polypeptide binding]; other site 114615007226 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase...; Region: trans_reg_C; cd00383 114615007227 DNA binding site [nucleotide binding] 114615007228 sensor protein PhoQ; Provisional; Region: PRK10815 114615007229 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 114615007230 ATP binding site [chemical binding]; other site 114615007231 Mg2+ binding site [ion binding]; other site 114615007232 G-X-G motif; other site 114615007233 Cytochrome c biogenesis factor [Posttranslational modification, protein turnover, chaperones]; Region: COG4235 114615007234 cytochrome c-type biogenesis protein CcmI; Region: cytochro_ccmI; TIGR03142 114615007235 CcmE; Region: CcmE; cl00994 114615007236 Cytochrome C assembly protein; Region: Cytochrom_C_asm; cl00504 114615007237 Cytochrome C biogenesis protein; Region: CcmH; cl01179 114615007238 TMAO reductase sytem sensor TorS; Region: TMAO_torS; TIGR02956 114615007239 Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices connected by an extended linker. The...; Region: HAMP; cl01054 114615007240 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 114615007241 Taxis toward Aspartate and Related amino acids and Homologs (TarH). The Tar chemoreceptor of Escherichia coli mediates attractant responses to aspartate, maltose, and phenol, repellent responses to Ni2+ and Co2+, and thermoresponses. These...; Region: TarH; cl00144 114615007242 Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices connected by an extended linker. The...; Region: HAMP; cl01054 114615007243 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 114615007244 Taxis toward Aspartate and Related amino acids and Homologs (TarH). The Tar chemoreceptor of Escherichia coli mediates attractant responses to aspartate, maltose, and phenol, repellent responses to Ni2+ and Co2+, and thermoresponses. These...; Region: TarH; cl00144 114615007245 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 114615007246 ABC transporter signature motif; other site 114615007247 Predicted ATP-dependent endonuclease of the OLD family [DNA replication, recombination, and repair]; Region: COG3593 114615007248 Walker B; other site 114615007249 D-loop; other site 114615007250 H-loop/switch region; other site 114615007251 periplasmic serine protease, Do/DeqQ family; Region: degP_htrA_DO; TIGR02037 114615007252 Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic...; Region: Tryp_SPc; cl00149 114615007253 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind C-...; Region: PDZ_serine_protease; cd00987 114615007254 protein binding site [polypeptide binding]; other site 114615007255 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind C-...; Region: PDZ_serine_protease; cd00987 114615007256 protein binding site [polypeptide binding]; other site 114615007257 heavy metal response regulator; Region: cztR_silR_copR; TIGR01387 114615007258 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156 114615007259 active site 114615007260 phosphorylation site [posttranslational modification] 114615007261 intermolecular recognition site; other site 114615007262 dimerization interface [polypeptide binding]; other site 114615007263 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase...; Region: trans_reg_C; cd00383 114615007264 DNA binding site [nucleotide binding] 114615007265 Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices connected by an extended linker. The...; Region: HAMP; cl01054 114615007266 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via trans-...; Region: HisKA; cd00082 114615007267 dimer interface [polypeptide binding]; other site 114615007268 phosphorylation site [posttranslational modification] 114615007269 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 114615007270 ATP binding site [chemical binding]; other site 114615007271 Mg2+ binding site [ion binding]; other site 114615007272 G-X-G motif; other site 114615007273 bifunctional glutamine-synthetase adenylyltransferase/deadenyltransferase; Provisional; Region: PRK14108 114615007274 Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401 114615007275 metal binding triad; other site 114615007276 GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335 114615007277 Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401 114615007278 metal binding triad; other site 114615007279 GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335 114615007280 cyclase homology domain; Region: CHD; cd07302 114615007281 nucleotidyl binding site; other site 114615007282 metal binding site [ion binding]; metal-binding site 114615007283 dimer interface [polypeptide binding]; other site 114615007284 Protein of unknown function (DUF3303); Region: DUF3303; pfam11746 114615007285 Caspase, interleukin-1 beta converting enzyme (ICE) homologues; Cysteine-dependent aspartate-directed proteases that mediate programmed cell death (apoptosis). Caspases are synthesized as inactive zymogens and activated by proteolysis of the peptide...; Region: CASc; cl00042 114615007286 glutamate and aspartate transporter subunit; Provisional; Region: PRK10797 114615007287 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and...; Region: PBPb; cd00134 114615007288 substrate binding pocket [chemical binding]; other site 114615007289 membrane-bound complex binding site; other site 114615007290 hinge residues; other site 114615007291 Dehydratase family; Region: ILVD_EDD; cl00340 114615007292 dihydroxy-acid dehydratase; Region: ilvD; TIGR00110 114615007293 Copper resistance protein CopC; Region: CopC; cl01012 114615007294 Copper resistance protein D; Region: CopD; cl00563 114615007295 Protein of unknown function (DUF3455); Region: DUF3455; pfam11937 114615007296 Isocitrate/isopropylmalate dehydrogenase; Region: Iso_dh; cl00445 114615007297 rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: LasT; COG0565 114615007298 SpoU rRNA Methylase family; Region: SpoU_methylase; cl00362 114615007299 Domain of unknown function, appears to be related to a diverse group of endonucleases; Region: Endonuclease_DUF559; cd01038 114615007300 putative active site [active] 114615007301 IIb; calcium-dependent cytoplasmic cysteine proteinases, papain-like. Functions in cytoskeletal remodeling processes, cell differentiation, apoptosis and signal transduction; Region: CysPc; cl00051 114615007302 catalytic site [active] 114615007303 A sub-family of peptidase C39 which contains Cyclolysin and Hemolysin processing peptidases. Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the 'double-glycine'...; Region: Peptidase_C39_likeA; cd02417 114615007304 type I secretion system ABC transporter, HlyB family; Region: type_I_sec_HlyB; TIGR01846 114615007305 ABC transporter transmembrane region; Region: ABC_membrane; cl00549 114615007306 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 114615007307 Walker A/P-loop; other site 114615007308 ATP binding site [chemical binding]; other site 114615007309 Q-loop/lid; other site 114615007310 ABC transporter signature motif; other site 114615007311 Walker B; other site 114615007312 D-loop; other site 114615007313 H-loop/switch region; other site 114615007314 type I secretion membrane fusion protein, HlyD family; Region: type_I_hlyD; TIGR01843 114615007315 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5330 114615007316 Uncharacterized protein conserved in bacteria (DUF2336); Region: DUF2336; pfam10098 114615007317 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 114615007318 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 114615007319 OsmC-like protein; Region: OsmC; cl00767 114615007320 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 114615007321 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 114615007322 active site 114615007323 Rhodanese-related sulfurtransferase [Inorganic ion transport and metabolism]; Region: SseA; COG2897 114615007324 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cl00125 114615007325 active site residue [active] 114615007326 Thiosulfate sulfurtransferase (TST), C-terminal, catalytic domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the second repeat. Only the second repeat contains the catalytically active Cys residue; Region: TST_Repeat_2; cd01449 114615007327 active site residue [active] 114615007328 ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components [Inorganic ion transport and metabolism]; Region: TauA; COG0715 114615007329 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 114615007330 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261 114615007331 dimer interface [polypeptide binding]; other site 114615007332 conserved gate region; other site 114615007333 putative PBP binding loops; other site 114615007334 ABC-ATPase subunit interface; other site 114615007335 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 114615007336 NrtD and SsuB are the ATP-binding subunits of the bacterial ABC-type nitrate and sulfonate transport systems, respectively. ABC transporters are a large family of proteins involved in the transport of a wide variety of different compounds, like sugars...; Region: ABC_NrtD_SsuB_transporters; cd03293 114615007337 Walker A/P-loop; other site 114615007338 ATP binding site [chemical binding]; other site 114615007339 Q-loop/lid; other site 114615007340 ABC transporter signature motif; other site 114615007341 Walker B; other site 114615007342 D-loop; other site 114615007343 H-loop/switch region; other site 114615007344 cyanate hydratase; Validated; Region: PRK02866 114615007345 Cyanase C-terminal domain. Cyanase (Cyanate lyase) is responsible for the hydrolysis of cyanate. It catalyzes the reaction of cyanate with bicarbonate to produce ammonia and carbon dioxide. This allows organisms that possess the enzyme to overcome the...; Region: Cyanase_C; cd00559 114615007346 oligomer interface [polypeptide binding]; other site 114615007347 active site 114615007348 Domain of unknown function (DUF1476); Region: DUF1476; cl11571 114615007349 phosphoribosylaminoimidazole-succinocarboxamide synthase; Reviewed; Region: PRK09362 114615007350 bacterial and archaeal 5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide (SAICAR) synthase; Region: SAICAR_synt_PurC; cd01415 114615007351 ATP binding site [chemical binding]; other site 114615007352 active site 114615007353 substrate binding site [chemical binding]; other site 114615007354 Phosphoribosylformylglycinamidine (FGAM) synthase; Region: PurS; cl00789 114615007355 Type 1 glutamine amidotransferase (GATase1)-like domain found in Formylglycinamide ribonucleotide amidotransferase; Region: GATase1_FGAR_AT; cd01740 114615007356 putative active site [active] 114615007357 catalytic triad [active] 114615007358 transcription termination factor Rho; Provisional; Region: PRK12678 114615007359 Protein of unknown function (DUF1236); Region: DUF1236; pfam06823 114615007360 Uncharacterized protein conserved in bacteria containing a divergent form of TPR repeats [Function unknown]; Region: COG4700 114615007361 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 114615007362 CoenzymeA binding site [chemical binding]; other site 114615007363 subunit interaction site [polypeptide binding]; other site 114615007364 PHB binding site; other site 114615007365 phosphoribosylformylglycinamidine synthase II; Provisional; Region: PRK01213 114615007366 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), first repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP...; Region: PurL_repeat1; cd02203 114615007367 dimerization interface [polypeptide binding]; other site 114615007368 ATP binding site [chemical binding]; other site 114615007369 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), second repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP...; Region: PurL_repeat2; cd02204 114615007370 dimerization interface [polypeptide binding]; other site 114615007371 ATP binding site [chemical binding]; other site 114615007372 Acyltransferase family; Region: Acyl_transf_3; pfam01757 114615007373 Predicted O-acyltransferase [General function prediction only]; Region: COG3274; cl00792 114615007374 Domain of unknown function (DUF427); Region: DUF427; cl00998 114615007375 BolA-like protein; Region: BolA; cl00386 114615007376 Bacterial low temperature requirement A protein (LtrA); Region: LtrA; cl01754 114615007377 probable methyltransferase; Region: TIGR03438 114615007378 Uncharacterized conserved protein (DUF2260); Region: DUF2260; pfam10017 114615007379 TIGR03440 family protein; Region: unchr_TIGR03440 114615007380 DinB superfamily; Region: DinB_2; cl00986 114615007381 Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; cl00556 114615007382 Glutaredoxin (GRX) family, PKC-interacting cousin of TRX (PICOT)-like subfamily; composed of PICOT and GRX-PICOT-like proteins. The non-PICOT members of this family contain only the GRX-like domain, whereas PICOT contains an N-terminal TRX-like domain...; Region: GRX_PICOT_like; cd03028 114615007383 putative GSH binding site [chemical binding]; other site 114615007384 catalytic residues [active] 114615007385 Macro domain, Appr-1'-pase_like family. The macro domain is a high-affinity ADP-ribose binding module found in a variety of proteins as a stand-alone domain or in combination with other domains like in histone macroH2A and some PARPs (poly ADP-ribose...; Region: Macro_Appr_pase_like; cd02908 114615007386 putative ADP-ribose binding site [chemical binding]; other site 114615007387 putative active site [active] 114615007388 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 114615007389 Beta-lactamase; Region: Beta-lactamase; cl01009 114615007390 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 114615007391 Beta-eliminating lyase; Region: Beta_elim_lyase; pfam01212 114615007392 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 114615007393 catalytic residue [active] 114615007394 30S ribosomal protein S4; Validated; Region: rpsD; PRK05327 114615007395 Ribosomal protein S4/S9 N-terminal domain; Region: Ribosomal_S4; pfam00163 114615007396 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 114615007397 RNA binding surface [nucleotide binding]; other site 114615007398 Cupin domain; Region: Cupin_2; cl09118 114615007399 2,4-dihydroxyhept-2-ene-1,7-dioic acid aldolase [Carbohydrate transport and metabolism]; Region: HpcH; COG3836 114615007400 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl09155 114615007401 Asp/Glu/Hydantoin racemase; Region: Asp_Glu_race; cl00518 114615007402 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 114615007403 dimerization interface [polypeptide binding]; other site 114615007404 putative DNA binding site [nucleotide binding]; other site 114615007405 putative Zn2+ binding site [ion binding]; other site 114615007406 Putative hydrophobic ligand-binding SRPBCC domain of Micromonospora echinospora CalC, human Aha1, and related proteins; Region: SRPBCC_CalC_Aha1-like; cd07814 114615007407 putative hydrophobic ligand binding site [chemical binding]; other site 114615007408 Glutathione-dependent formaldehyde-activating enzyme; Region: GFA; cl01553 114615007409 Protein of unknown function, DUF393; Region: DUF393; cl01136 114615007410 D-alanyl-alanine synthetase A; Reviewed; Region: ddl; PRK01966 114615007411 D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820 114615007412 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; cl03087 114615007413 Staphylococcal nuclease homologues; Region: SNc; smart00318 114615007414 Staphylococcal nuclease homologues. SNase homologues are found in bacteria, archaea, and eukaryotes. They contain no disufide bonds; Region: SNc; cl00140 114615007415 Catalytic site; other site 114615007416 hypothetical protein; Provisional; Region: PRK13559 114615007417 Histidine kinase; Region: HisKA_2; cl06527 114615007418 Medium chain dehydrogenases/reductase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR7; cd08276 114615007419 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 114615007420 putative NAD(P) binding site [chemical binding]; other site 114615007421 putative DMT superfamily transporter inner membrane protein; Provisional; Region: PRK11272 114615007422 EamA-like transporter family; Region: EamA; cl01037 114615007423 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 114615007424 M20 Peptidase Aminoacylase 1 subfamily; Region: M20_Acy1_like1; cd05666 114615007425 metal binding site [ion binding]; metal-binding site 114615007426 putative dimer interface [polypeptide binding]; other site 114615007427 Uncharacterized conserved protein [Function unknown]; Region: COG3025 114615007428 Uncharacterized subgroup of the CYTH-like superfamily having an associated CHAD domain; Region: CYTH-like_Pase_CHAD; cd07756 114615007429 putative active site [active] 114615007430 putative metal binding residues [ion binding]; other site 114615007431 signature motif; other site 114615007432 putative triphosphate binding site [ion binding]; other site 114615007433 CHAD domain; Region: CHAD; cl10506 114615007434 Exopolysaccharide synthesis, ExoD; Region: ExoD; cl01617 114615007435 Integral membrane protein TerC family; Region: TerC; cl10468 114615007436 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; cl01255 114615007437 putative lipid kinase; Reviewed; Region: PRK13057 114615007438 FtsH Extracellular; Region: FtsH_ext; pfam06480 114615007439 ATP-dependent metalloprotease FtsH; Region: FtsH_fam; TIGR01241 114615007440 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes...; Region: AAA; cd00009 114615007441 Walker A motif; other site 114615007442 ATP binding site [chemical binding]; other site 114615007443 Walker B motif; other site 114615007444 arginine finger; other site 114615007445 Peptidase family M41; Region: Peptidase_M41; pfam01434 114615007446 Cytochrome b (N-terminus)/b6/petB: Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria...; Region: Cytochrome_b_N; cl00859 114615007447 Cytochrome b (N-terminus)/b6/petB: Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria...; Region: Cytochrome_b_N; cl00859 114615007448 Cytochrome b (N-terminus)/b6/petB: Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria...; Region: Cytochrome_b_N; cl00859 114615007449 adenylosuccinate lyase; Provisional; Region: PRK07492 114615007450 Adenylsuccinate lyase (ASL)_subgroup 1; Region: Adenylsuccinate_lyase_1; cd01360 114615007451 tetramer interface [polypeptide binding]; other site 114615007452 active site 114615007453 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 114615007454 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 114615007455 S1/P1 Nuclease; Region: S1-P1_nuclease; pfam02265 114615007456 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 114615007457 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cd00838 114615007458 active site 114615007459 metal binding site [ion binding]; metal-binding site 114615007460 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 114615007461 Catalytic domain of Protein Kinases; Region: PKc; cd00180 114615007462 active site 114615007463 ATP binding site [chemical binding]; other site 114615007464 substrate binding site [chemical binding]; other site 114615007465 activation loop (A-loop); other site 114615007466 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 114615007467 Ligand Binding Site [chemical binding]; other site 114615007468 Sodium:dicarboxylate symporter family; Region: SDF; cl00573 114615007469 hypothetical protein; Provisional; Region: PRK11171 114615007470 Cupin domain; Region: Cupin_2; cl09118 114615007471 Cupin domain; Region: Cupin_2; cl09118 114615007472 Ureidoglycolate hydrolase [Nucleotide transport and metabolism]; Region: DAL3; COG3194 114615007473 Ureidoglycolate hydrolase; Region: Ureidogly_hydro; cl01250 114615007474 Pentose-5-phosphate-3-epimerase [Carbohydrate transport and metabolism]; Region: Rpe; COG0036 114615007475 Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative...; Region: RPE; cd00429 114615007476 substrate binding site [chemical binding]; other site 114615007477 hexamer interface [polypeptide binding]; other site 114615007478 metal binding site [ion binding]; metal-binding site 114615007479 EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading...; Region: EFh; cd00051 114615007480 Ca2+ binding site [ion binding]; other site 114615007481 nylC-like family; composed of proteins with similarity to Flavobacterium endo-type 6-aminohexanoate-oligomer hydrolase (EIII), the product of the nylon oligomer degradation gene, nylC. EIII is an amide hydrolase that catalyzes the degradation of highly-; Region: nylC_like; cd02252 114615007482 putative active site pocket [active] 114615007483 cleavage site 114615007484 PAS domain S-box; Region: sensory_box; TIGR00229 114615007485 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 114615007486 putative active site [active] 114615007487 heme pocket [chemical binding]; other site 114615007488 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 114615007489 Signal transduction histidine kinase, nitrogen specific [Signal transduction mechanisms]; Region: NtrB; COG3852 114615007490 putative active site [active] 114615007491 heme pocket [chemical binding]; other site 114615007492 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via trans-...; Region: HisKA; cd00082 114615007493 dimer interface [polypeptide binding]; other site 114615007494 phosphorylation site [posttranslational modification] 114615007495 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 114615007496 ATP binding site [chemical binding]; other site 114615007497 Mg2+ binding site [ion binding]; other site 114615007498 G-X-G motif; other site 114615007499 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 114615007500 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156 114615007501 active site 114615007502 phosphorylation site [posttranslational modification] 114615007503 intermolecular recognition site; other site 114615007504 dimerization interface [polypeptide binding]; other site 114615007505 Response regulator receiver domain; Region: Response_reg; pfam00072 114615007506 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156 114615007507 active site 114615007508 phosphorylation site [posttranslational modification] 114615007509 intermolecular recognition site; other site 114615007510 dimerization interface [polypeptide binding]; other site 114615007511 ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683 114615007512 Type I periplasmic ligand-binding domain of ABC (Atpase Binding Cassette)-type active transport systems that are involved in the transport of all three branched chain aliphatic amino acids (leucine, isoleucine and valine); Region: PBP1_ABC_LIVBP_like; cd06342 114615007513 dimerization interface [polypeptide binding]; other site 114615007514 ligand binding site [chemical binding]; other site 114615007515 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410 114615007516 LivF (TM1139) is part of the LIV-I bacterial ABC-type two-component transport system that imports neutral, branched-chain amino acids. The E. coli branched-chain amino acid transporter comprises a heterodimer of ABC transporters (LivF and LivG), a...; Region: ABC_TM1139_LivF_branched; cd03224 114615007517 Walker A/P-loop; other site 114615007518 ATP binding site [chemical binding]; other site 114615007519 Q-loop/lid; other site 114615007520 ABC transporter signature motif; other site 114615007521 Walker B; other site 114615007522 D-loop; other site 114615007523 H-loop/switch region; other site 114615007524 leucine/isoleucine/valine transporter ATP-binding subunit; Provisional; Region: livG; PRK11300 114615007525 The Mj1267/LivG ABC transporter subfamily is involved in the transport of the hydrophobic amino acids leucine, isoleucine and valine. MJ1267 is a branched-chain amino acid transporter with 29% similarity to both the LivF and LivG components of the E...; Region: ABC_Mj1267_LivG_branched; cd03219 114615007526 Walker A/P-loop; other site 114615007527 ATP binding site [chemical binding]; other site 114615007528 Q-loop/lid; other site 114615007529 ABC transporter signature motif; other site 114615007530 Walker B; other site 114615007531 D-loop; other site 114615007532 H-loop/switch region; other site 114615007533 Domain of unknown function (DUF3382); Region: DUF3382; pfam11862 114615007534 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 114615007535 TM-ABC transporter signature motif; other site 114615007536 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 114615007537 TM-ABC transporter signature motif; other site 114615007538 3-oxoadipate enol-lactonase; Region: protocat_pcaD; TIGR02427 114615007539 Carbon monoxide dehydrogenase subunit G (CoxG); Region: CoxG; cd05018 114615007540 putative hydrophobic ligand binding site [chemical binding]; other site 114615007541 Aerobic-type carbon monoxide dehydrogenase, small subunit CoxS/CutS homologs [Energy production and conversion]; Region: CoxS; COG2080 114615007542 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cl00159 114615007543 [2Fe-2S] binding domain; Region: Fer2_2; pfam01799 114615007544 Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM/CutM homologs [Energy production and conversion]; Region: CoxM; COG1319 114615007545 CO dehydrogenase flavoprotein C-terminal domain; Region: CO_deh_flav_C; cl08390 114615007546 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes...; Region: AAA; cd00009 114615007547 AAA domain (dynein-related subfamily); Region: AAA_5; pfam07728 114615007548 Walker A motif; other site 114615007549 ATP binding site [chemical binding]; other site 114615007550 Walker B motif; other site 114615007551 arginine finger; other site 114615007552 Protein containing von Willebrand factor type A (vWA) domain [General function prediction only]; Region: CoxE; COG3552 114615007553 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198 114615007554 metal ion-dependent adhesion site (MIDAS); other site 114615007555 XdhC and CoxI family; Region: XdhC_CoxI; pfam02625 114615007556 Xanthine and CO dehydrogenases maturation factor, XdhC/CoxF family [Posttranslational modification, protein turnover, chaperones]; Region: XdhC; COG1975 114615007557 MoeA_like. This domain is similar to a domain found in a variety of proteins involved in biosynthesis of molybdopterin cofactor, like MoaB, MogA, and MoeA. There this domain is presumed to bind molybdopterin. The exact function of this subgroup is...; Region: MoeA_like; cd03522 114615007558 putative MPT binding site; other site 114615007559 GT_2_like_f is a subfamily of the glycosyltransferase family 2 (GT-2) with unknown function; Region: GT_2_like_f; cd04182 114615007560 molybdopterin-guanine dinucleotide biosynthesis protein MobA; Reviewed; Region: mobA; PRK00317 114615007561 Ligand binding site [chemical binding]; other site 114615007562 metal binding site [ion binding]; metal-binding site 114615007563 Protein of unknown function (DUF2000); Region: DUF2000; cl02074 114615007564 Zn-dependent alcohol dehydrogenases [General function prediction only]; Region: AdhP; COG1064 114615007565 Cinnamyl alcohol dehydrogenases (CAD); Region: CAD3; cd08297 114615007566 NAD binding site [chemical binding]; other site 114615007567 substrate binding site [chemical binding]; other site 114615007568 catalytic Zn binding site [ion binding]; other site 114615007569 tetramer interface [polypeptide binding]; other site 114615007570 structural Zn binding site [ion binding]; other site 114615007571 NAD-dependent, lactate dehydrogenase-like, 2-hydroxycarboxylate dehydrogenase family; Region: LDH_MDH_like; cl11406 114615007572 alpha-galactosidase; Provisional; Region: PRK15076 114615007573 NAD(P) binding site [chemical binding]; other site 114615007574 LDH/MDH dimer interface [polypeptide binding]; other site 114615007575 substrate binding site [chemical binding]; other site 114615007576 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 114615007577 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 114615007578 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 114615007579 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 114615007580 This family of ATP-binding proteins belongs to a multisubunit transporter involved in drug resistance (BcrA and DrrA), nodulation, lipid transport, and lantibiotic immunity. In bacteria and archaea, these transporters usually include an ATP-binding...; Region: ABC_DR_subfamily_A; cd03230 114615007581 Walker A/P-loop; other site 114615007582 ATP binding site [chemical binding]; other site 114615007583 Q-loop/lid; other site 114615007584 ABC transporter signature motif; other site 114615007585 Walker B; other site 114615007586 D-loop; other site 114615007587 H-loop/switch region; other site 114615007588 ABC-type Na+ efflux pump, permease component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatB; COG1668 114615007589 ABC-2 type transporter; Region: ABC2_membrane; cl11417 114615007590 cyclase homology domain; Region: CHD; cd07302 114615007591 nucleotidyl binding site; other site 114615007592 metal binding site [ion binding]; metal-binding site 114615007593 dimer interface [polypeptide binding]; other site 114615007594 Tannase and feruloyl esterase; Region: Tannase; pfam07519 114615007595 Protein of unknown function, DUF488; Region: DUF488; cl01246 114615007596 Protein of unknown function DUF72; Region: DUF72; cl00777 114615007597 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 114615007598 DPM1_like represents putative enzymes similar to eukaryotic DPM1; Region: DPM1_like; cd06442 114615007599 Ligand binding site [chemical binding]; other site 114615007600 Putative Catalytic site [active] 114615007601 DXD motif; other site 114615007602 GtrA-like protein; Region: GtrA; cl00971 114615007603 4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family [Cell envelope biogenesis, outer membrane]; Region: ArnT; COG1807 114615007604 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cl12011 114615007605 Protein of unknown function (DUF2778); Region: DUF2778; pfam10908 114615007606 aldehyde oxidoreductase 2Fe-2S subunit; Provisional; Region: PRK11433 114615007607 [2Fe-2S] binding domain; Region: Fer2_2; pfam01799 114615007608 Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM/CutM homologs [Energy production and conversion]; Region: CoxM; COG1319 114615007609 CO dehydrogenase flavoprotein C-terminal domain; Region: CO_deh_flav_C; cl08390 114615007610 Aerobic-type carbon monoxide dehydrogenase, large subunit CoxL/CutL homologs [Energy production and conversion]; Region: CoxL; COG1529 114615007611 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; cl03161 114615007612 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 114615007613 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins...; Region: HNHc; cd00085 114615007614 active site 114615007615 hypothetical protein; Reviewed; Region: PRK09588 114615007616 Hedgehog/Intein domain, found in Hedgehog proteins as well as proteins which contain inteins and undergo protein splicing (e.g. DnaB, RIR1-2, GyrA and Pol). In protein splicing an intervening polypeptide sequence - the intein - is excised from a...; Region: Hint; cl12032 114615007617 signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227 114615007618 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 114615007619 Catalytic site [active] 114615007620 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 114615007621 Isochorismatase family; Region: Isochorismatase; pfam00857 114615007622 Nicotinamidase_ related amidohydrolases. Cysteine hydrolases of unknown function that share the catalytic triad with other amidohydrolases, like nicotinamidase, which converts nicotinamide to nicotinic acid and ammonia; Region: nicotinamidase_related; cd01014 114615007623 catalytic triad [active] 114615007624 conserved cis-peptide bond; other site 114615007625 Transcriptional regulator [Transcription]; Region: LysR; COG0583 114615007626 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 114615007627 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 114615007628 dimerization interface [polypeptide binding]; other site 114615007629 chaperonin GroEL; Reviewed; Region: groEL; PRK12849 114615007630 GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344 114615007631 ring oligomerisation interface [polypeptide binding]; other site 114615007632 ATP/Mg binding site [chemical binding]; other site 114615007633 stacking interactions; other site 114615007634 hinge regions; other site 114615007635 Chaperonin 10 Kd subunit (cpn10 or GroES); Cpn10 cooperates with chaperonin 60 (cpn60 or GroEL), an ATPase, to assist the folding and assembly of proteins and is found in eubacterial cytosol, as well as in the matrix of mitochondria and chloroplasts...; Region: cpn10; cd00320 114615007636 oligomerisation interface [polypeptide binding]; other site 114615007637 mobile loop; other site 114615007638 roof hairpin; other site 114615007639 Usg-like family; Region: Usg; cl11567 114615007640 Cupin domain; Region: Cupin_2; cl09118 114615007641 Predicted acyltransferases [Lipid metabolism]; Region: COG1835 114615007642 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 114615007643 Nucleoside permease [Nucleotide transport and metabolism]; Region: NupC; COG1972 114615007644 Na+ dependent nucleoside transporter N-terminus; Region: Nucleos_tra2_N; pfam01773 114615007645 Nucleoside recognition; Region: Gate; cl00486 114615007646 Na+ dependent nucleoside transporter C-terminus; Region: Nucleos_tra2_C; pfam07662 114615007647 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 114615007648 H+ Antiporter protein; Region: 2A0121; TIGR00900 114615007649 putative substrate translocation pore; other site 114615007650 Transposase IS200 like; Region: Y1_Tnp; cl00848 114615007651 classical (c) SDRs; Region: SDR_c; cd05233 114615007652 acetoacetyl-CoA reductase; Region: AcAcCoA_reduct; TIGR01829 114615007653 NAD(P) binding site [chemical binding]; other site 114615007654 active site 114615007655 Predicted proteasome-type protease [Posttranslational modification, protein turnover, chaperones]; Region: COG3484 114615007656 The Ntn hydrolases (N-terminal nucleophile) are a diverse superfamily of of enzymes that are activated autocatalytically via an N-terminally lcated nucleophilic amino acid. N-terminal nucleophile (NTN-) hydrolase superfamily, which contains a four-...; Region: Ntn_hydrolase; cl00467 114615007657 active site 114615007658 Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305 114615007659 Bacterial transglutaminase-like N-terminal region; Region: Bact_transglu_N; pfam08379 114615007660 Transglutaminase-like superfamily; Region: Transglut_core; cl10469 114615007661 Bacterial domain of unknown function (DUF403); Region: DUF403; cl00980 114615007662 Uncharacterized conserved protein [Function unknown]; Region: COG2308 114615007663 Domain of unknown function (DUF404); Region: DUF404; pfam04169 114615007664 Domain of unknown function (DUF407); Region: DUF407; pfam04174 114615007665 Predicted nucleotide-utilizing enzyme related to molybdopterin-biosynthesis enzyme MoeA [General function prediction only]; Region: CinA; COG1058 114615007666 Competence-damaged protein. CinA is the first gene in the competence- inducible (cin) operon and is thought to be specifically required at some stage in the process of transformation. This domain is closely related to a domain, found in a variety of...; Region: cinA; cd00885 114615007667 putative MPT binding site; other site 114615007668 Phosphoribosyl transferase domain; Region: Pribosyltran; cl00309 114615007669 C-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme catalyses the last step in the production of methionine by...; Region: CIMS_C_terminal_like; cd03311 114615007670 substrate binding site [chemical binding]; other site 114615007671 methionine synthase; Provisional; Region: PRK01207 114615007672 THF binding site; other site 114615007673 zinc-binding site [ion binding]; other site 114615007674 GSH-dependent disulfide bond oxidoreductase; Provisional; Region: PRK13972 114615007675 GST_N family, Ure2p-like subfamily; composed of the Saccharomyces cerevisiae Ure2p and related GSTs. Ure2p is a regulator for nitrogen catabolism in yeast. It represses the expression of several gene products involved in the use of poor nitrogen...; Region: GST_N_Ure2p_like; cd03048 114615007676 C-terminal domain interface [polypeptide binding]; other site 114615007677 GSH binding site (G-site) [chemical binding]; other site 114615007678 dimer interface [polypeptide binding]; other site 114615007679 C-terminal, alpha helical domain of the Glutathione S-transferase family; Region: GST_C_family; cl02776 114615007680 N-terminal domain interface [polypeptide binding]; other site 114615007681 dimer interface [polypeptide binding]; other site 114615007682 substrate binding pocket (H-site) [chemical binding]; other site 114615007683 2-hydroxychromene-2-carboxylate isomerase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: NahD; COG3917 114615007684 DsbA family, 2-hydroxychromene-2-carboxylate (HCCA) isomerase subfamily; HCCA isomerase is a glutathione (GSH) dependent enzyme involved in the naphthalene catabolic pathway. It converts HCCA, a hemiketal formed spontaneously after ring cleavage of 1,2-; Region: DsbA_HCCA_Iso; cd03022 114615007685 putative catalytic residue [active] 114615007686 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 114615007687 Quinone oxidoreductase (QOR); Region: QOR1; cd08241 114615007688 NAD(P) binding site [chemical binding]; other site 114615007689 enoyl-CoA hydratase; Provisional; Region: PRK08260 114615007690 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase...; Region: crotonase-like; cd06558 114615007691 substrate binding site [chemical binding]; other site 114615007692 oxyanion hole (OAH) forming residues; other site 114615007693 trimer interface [polypeptide binding]; other site 114615007694 amidase; Provisional; Region: PRK07042 114615007695 GGCT-like domains, also called AIG2-like family. Gamma-glutamyl cyclotransferase (GGCT) catalyzes the formation of pyroglutamic acid (5-oxoproline) from dipeptides containing gamma-glutamyl, and is a dimeric protein. In Homo sapiens, the protein is...; Region: GGCT_like; cl11426 114615007696 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 114615007697 M20 Peptidase Aminoacylase 1 subfamily; Region: M20_Acy1_like1; cd05666 114615007698 metal binding site [ion binding]; metal-binding site 114615007699 putative dimer interface [polypeptide binding]; other site 114615007700 Protein of unknown function (DUF1485); Region: DUF1485; pfam07364 114615007701 Uncharacterized conserved protein [Function unknown]; Region: COG5476 114615007702 MlrC C-terminus; Region: MlrC_C; pfam07171 114615007703 ATPase components of various ABC-type transport systems, contain duplicated ATPase [General function prediction only]; Region: COG1123 114615007704 The ABC transporter subfamily specific for the transport of dipeptides, oligopeptides (OppD), and nickel (NikDE). The NikABCDE system of E. coli belongs to this family and is composed of the periplasmic binding protein NikA, two integral membrane...; Region: ABC_NikE_OppD_transporters; cd03257 114615007705 Walker A/P-loop; other site 114615007706 ATP binding site [chemical binding]; other site 114615007707 Q-loop/lid; other site 114615007708 ABC transporter signature motif; other site 114615007709 Walker B; other site 114615007710 D-loop; other site 114615007711 H-loop/switch region; other site 114615007712 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 114615007713 The ABC transporter subfamily specific for the transport of dipeptides, oligopeptides (OppD), and nickel (NikDE). The NikABCDE system of E. coli belongs to this family and is composed of the periplasmic binding protein NikA, two integral membrane...; Region: ABC_NikE_OppD_transporters; cd03257 114615007714 Walker A/P-loop; other site 114615007715 ATP binding site [chemical binding]; other site 114615007716 Q-loop/lid; other site 114615007717 ABC transporter signature motif; other site 114615007718 Walker B; other site 114615007719 D-loop; other site 114615007720 H-loop/switch region; other site 114615007721 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 114615007722 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 114615007723 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261 114615007724 dimer interface [polypeptide binding]; other site 114615007725 conserved gate region; other site 114615007726 putative PBP binding loops; other site 114615007727 ABC-ATPase subunit interface; other site 114615007728 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 114615007729 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261 114615007730 dimer interface [polypeptide binding]; other site 114615007731 conserved gate region; other site 114615007732 putative PBP binding loops; other site 114615007733 ABC-ATPase subunit interface; other site 114615007734 hypothetical protein; Provisional; Region: PRK07338 114615007735 M20 Peptidase Glutamate carboxypeptidase, a periplasmic enzyme; Region: M20_CPDG2; cd03885 114615007736 metal binding site [ion binding]; metal-binding site 114615007737 dimer interface [polypeptide binding]; other site 114615007738 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_16; cd08502 114615007739 Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496 114615007740 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_16; cd08502 114615007741 Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496 114615007742 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 114615007743 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_16; cd08502 114615007744 Taxis toward Aspartate and Related amino acids and Homologs (TarH). The Tar chemoreceptor of Escherichia coli mediates attractant responses to aspartate, maltose, and phenol, repellent responses to Ni2+ and Co2+, and thermoresponses. These...; Region: TarH; cl00144 114615007745 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 114615007746 dimerization interface [polypeptide binding]; other site 114615007747 putative DNA binding site [nucleotide binding]; other site 114615007748 putative Zn2+ binding site [ion binding]; other site 114615007749 Ligand-binding SRPBCC domain of Micromonospora echinospora CalC and related proteins; Region: SRPBCC_CalC; cd08891 114615007750 putative hydrophobic ligand binding site [chemical binding]; other site 114615007751 CLM binding site; other site 114615007752 L1 loop; other site 114615007753 DNA binding site [nucleotide binding] 114615007754 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 114615007755 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 114615007756 C-terminal, alpha helical domain of the Glutathione S-transferase family; Region: GST_C_family; cd00299 114615007757 N-terminal domain interface [polypeptide binding]; other site 114615007758 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 114615007759 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 114615007760 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 114615007761 NAD(P) binding site [chemical binding]; other site 114615007762 active site 114615007763 salicylate hydroxylase; Provisional; Region: PRK08163 114615007764 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 114615007765 Zinc-finger domain; Region: zf-CHCC; cl01821 114615007766 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 114615007767 serine acetyltransferase; Provisional; Region: cysE; PRK11132 114615007768 Serine acetyltransferase, N-terminal; Region: SATase_N; cl05762 114615007769 Serine acetyltransferase (SAT): SAT catalyzes the CoA-dependent acetylation of the side chain hydroxyl group of L-serine to form O-acetylserine, as the first step of a two-step biosynthetic pathway in bacteria and plants leading to the formation of L-...; Region: LbH_SAT; cd03354 114615007770 trimer interface [polypeptide binding]; other site 114615007771 active site 114615007772 substrate binding site [chemical binding]; other site 114615007773 CoA binding site [chemical binding]; other site 114615007774 Protein of unknown function (DUF3126); Region: DUF3126; pfam11324 114615007775 Carbonic anhydrases/acetyltransferases, isoleucine patch superfamily [General function prediction only]; Region: PaaY; COG0663 114615007776 Gamma carbonic anhydrase-like: This family is composed of gamma carbonic anhydrase (CA), Ferripyochelin Binding Protein (FBP), E. coli paaY protein, and similar proteins. CAs are zinc-containing enzymes that catalyze the reversible hydration of carbon...; Region: LbH_gamma_CA_like; cd04645 114615007777 trimer interface [polypeptide binding]; other site 114615007778 putative metal binding site [ion binding]; other site 114615007779 Ribbon-helix-helix domain; Region: RHH_3; pfam12651 114615007780 Transposase domain (DUF772); Region: DUF772; cl12084 114615007781 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 114615007782 Dienelactone hydrolase family; Region: DLH; pfam01738 114615007783 Transglutaminase-like superfamily; Region: Transglut_core; cl10469 114615007784 PilZ domain; Region: PilZ; cl01260 114615007785 PilZ domain; Region: PilZ; cl01260 114615007786 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5388 114615007787 PAS domain; Region: PAS_5; pfam07310 114615007788 Rhomboid family; Region: Rhomboid; cl11446 114615007789 FOG: CBS domain [General function prediction only]; Region: COG0517 114615007790 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-...; Region: CBS_pair_10; cd04623 114615007791 hypothetical protein; Provisional; Region: PRK10279 114615007792 Patatins and Phospholipases; Region: Patatin_and_cPLA2; cl11396 114615007793 nucleophile elbow; other site 114615007794 putative Helix-turn-helix domain of transposase IS66; Region: HTH_Tnp_IS66; cl14891 114615007795 Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050 114615007796 Transposase domain (DUF772); Region: DUF772; cl12084 114615007797 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 114615007798 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 114615007799 Leucine carboxyl methyltransferase; Region: LCM; cl01306 114615007800 PAS domain S-box; Region: sensory_box; TIGR00229 114615007801 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 114615007802 putative active site [active] 114615007803 heme pocket [chemical binding]; other site 114615007804 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 114615007805 metal binding site [ion binding]; metal-binding site 114615007806 active site 114615007807 I-site; other site 114615007808 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 114615007809 Nitroreductase-like family which includes NADH oxidase and arsenite oxidiase. NADH oxidase catalyses the oxidation of NAD(P)H and accepts a wide broad range of compounds as electron acceptors, such as nitrocompound. Arsenite oxidase in a beta-...; Region: Arsenite_oxidase; cd02135 114615007810 putative FMN binding site [chemical binding]; other site 114615007811 threonyl-tRNA synthetase; Reviewed; Region: thrS; PRK00413 114615007812 TGS _ThrRS_N: ThrRS (threonyl-tRNA Synthetase) is a class II tRNA synthetase that couples threonine to its cognate tRNA. In addition to its catalytic and anticodon-binding domains, ThrRS has an N-terminal TGS domain, named after the ThrRS, GTPase...; Region: TGS_ThrRS_N; cd01667 114615007813 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; cl08469 114615007814 Threonyl-tRNA synthetase (ThrRS) class II core catalytic domain. ThrRS is a homodimer. It is responsible for the attachment of threonine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ThrRS_core; cd00771 114615007815 active site 114615007816 dimer interface [polypeptide binding]; other site 114615007817 motif 1; other site 114615007818 motif 2; other site 114615007819 motif 3; other site 114615007820 ThrRS Threonyl-anticodon binding domain. ThrRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: ThrRS_anticodon; cd00860 114615007821 anticodon binding site; other site 114615007822 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase...; Region: crotonase-like; cl14780 114615007823 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 114615007824 putative substrate translocation pore; other site 114615007825 Transmembrane amino acid transporter protein; Region: Aa_trans; cl00524 114615007826 Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531 114615007827 Domain of unknown function DUF37; Region: DUF37; cl00506 114615007828 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase...; Region: crotonase-like; cl14780 114615007829 Iron-sulfur cluster scaffold-like proteins; Region: IscU_like; cd06664 114615007830 trimerization site [polypeptide binding]; other site 114615007831 active site 114615007832 GTP cyclohydrolase I; Provisional; Region: PLN03044 114615007833 Tunnelling fold (T-fold). The five known T-folds are found in five different enzymes with different functions: dihydroneopterin-triphosphate epimerase (DHNTPE), dihydroneopterin aldolase (DHNA) , GTP cyclohydrolase I (GTPCH-1), 6-pyrovoyl...; Region: TFold; cl00263 114615007834 active site 114615007835 Phosphoribosyl-AMP cyclohydrolase; Region: PRA-CH; cl00344 114615007836 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic 'goose-type' lysozymes (GEWL). LTs catalyze...; Region: LT_GEWL; cd00254 114615007837 N-acetyl-D-glucosamine binding site [chemical binding]; other site 114615007838 catalytic residue [active] 114615007839 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5330 114615007840 Uncharacterized protein conserved in bacteria (DUF2336); Region: DUF2336; pfam10098 114615007841 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cl00086 114615007842 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156 114615007843 Response regulator receiver domain; Region: Response_reg; pfam00072 114615007844 active site 114615007845 phosphorylation site [posttranslational modification] 114615007846 intermolecular recognition site; other site 114615007847 dimerization interface [polypeptide binding]; other site 114615007848 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; cl01255 114615007849 CHASE2 domain; Region: CHASE2; cl01732 114615007850 CHASE2 is an extracellular sensory domain, which is present in various classes of transmembrane receptors that are parts of signal transduction pathways in bacteria; Region: CHASE2; smart01080 114615007851 cyclase homology domain; Region: CHD; cd07302 114615007852 nucleotidyl binding site; other site 114615007853 metal binding site [ion binding]; metal-binding site 114615007854 dimer interface [polypeptide binding]; other site 114615007855 Carboxypeptidase C (cathepsin A) [Amino acid transport and metabolism]; Region: COG2939 114615007856 Serine carboxypeptidase; Region: Peptidase_S10; cl08270 114615007857 Beta-lactamase; Region: Beta-lactamase; cl01009 114615007858 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi...; Region: TPR; cd00189 114615007859 TPR motif; other site 114615007860 binding surface 114615007861 Surface antigen; Region: Surface_Ag_2; cl01155 114615007862 rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566 114615007863 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; cl06870 114615007864 SpoU rRNA Methylase family; Region: SpoU_methylase; cl00362 114615007865 Predicted acyltransferases [Lipid metabolism]; Region: COG1835 114615007866 Protein of unknown function (DUF1211); Region: DUF1211; cl01421 114615007867 Transcriptional regulator [Transcription]; Region: LysR; COG0583 114615007868 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 114615007869 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 114615007870 dimerization interface [polypeptide binding]; other site 114615007871 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084 114615007872 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 114615007873 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 114615007874 Uncharacterized Candidatus pelagibacter aldehyde dehydrogenase, DhaS-like; Region: ALDH_DhaS; cd07114 114615007875 NAD(P) binding site [chemical binding]; other site 114615007876 catalytic residues [active] 114615007877 Predicted amidohydrolase [General function prediction only]; Region: COG0388 114615007878 N-carbamyl-D-amino acid amidohydrolase (DCase, class 6 nitrilases); Region: DCase; cd07569 114615007879 tetramer interface [polypeptide binding]; other site 114615007880 active site 114615007881 catalytic triad [active] 114615007882 dimer interface [polypeptide binding]; other site 114615007883 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 114615007884 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_16; cd08502 114615007885 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 114615007886 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cl00427 114615007887 nickel ABC transporter, permease subunit NikC; Region: nickel_nikC; TIGR02790 114615007888 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261 114615007889 dimer interface [polypeptide binding]; other site 114615007890 conserved gate region; other site 114615007891 putative PBP binding loops; other site 114615007892 ABC-ATPase subunit interface; other site 114615007893 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 114615007894 The ABC transporter subfamily specific for the transport of dipeptides, oligopeptides (OppD), and nickel (NikDE). The NikABCDE system of E. coli belongs to this family and is composed of the periplasmic binding protein NikA, two integral membrane...; Region: ABC_NikE_OppD_transporters; cd03257 114615007895 Walker A/P-loop; other site 114615007896 ATP binding site [chemical binding]; other site 114615007897 Q-loop/lid; other site 114615007898 ABC transporter signature motif; other site 114615007899 Walker B; other site 114615007900 D-loop; other site 114615007901 H-loop/switch region; other site 114615007902 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 114615007903 dipeptide transporter ATP-binding subunit; Provisional; Region: dppF; PRK11308 114615007904 The ABC transporter subfamily specific for the transport of dipeptides, oligopeptides (OppD), and nickel (NikDE). The NikABCDE system of E. coli belongs to this family and is composed of the periplasmic binding protein NikA, two integral membrane...; Region: ABC_NikE_OppD_transporters; cd03257 114615007905 Walker A/P-loop; other site 114615007906 ATP binding site [chemical binding]; other site 114615007907 Q-loop/lid; other site 114615007908 ABC transporter signature motif; other site 114615007909 Walker B; other site 114615007910 D-loop; other site 114615007911 H-loop/switch region; other site 114615007912 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 114615007913 tRNA-binding-domain-containing CsaA-like proteins. CsaA is a molecular chaperone with export related activities. CsaA has a putative tRNA binding activity. The functional unit of CsaA is a homodimer and this domain acts as a dimerization domain; Region: tRNA_bind_CsaA; cd02798 114615007914 dimer interface [polypeptide binding]; other site 114615007915 putative tRNA-binding site [nucleotide binding]; other site 114615007916 1,4-alpha-glucan branching enzyme [Carbohydrate transport and metabolism]; Region: GlgB; COG0296 114615007917 E or 'early' set of sugar utilizing enzymes which may be related to the immunoglobulin and/or fibronectin type III superfamilies. These domains are associated with different types of catalytic domains at either the N-terminal or C-terminal end; Region: E_set; cl09101 114615007918 Alpha amylase, catalytic domain; Region: Alpha-amylase; cl07893 114615007919 Alpha amylase, C-terminal all-beta domain; Region: Alpha-amylase_C; cl02706 114615007920 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; cl01255 114615007921 The band 7 domain of flotillin (reggie) like proteins. This group contains proteins similar to stomatin, prohibitin, flotillin, HlfK/C and podicin. Many of these band 7 domain-containing proteins are lipid raft-associated. Individual proteins of this...; Region: Band_7; cl02525 114615007922 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or...; Region: Nudix_Hydrolase; cl00447 114615007923 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or...; Region: Nudix_Hydrolase; cl00447 114615007924 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 114615007925 Taxis toward Aspartate and Related amino acids and Homologs (TarH). The Tar chemoreceptor of Escherichia coli mediates attractant responses to aspartate, maltose, and phenol, repellent responses to Ni2+ and Co2+, and thermoresponses. These...; Region: TarH; cl00144 114615007926 CoA-transferase family III; Region: CoA_transf_3; cl00778 114615007927 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 114615007928 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 114615007929 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 114615007930 active site 114615007931 Predicted aminoglycoside phosphotransferase [General function prediction only]; Region: COG3173 114615007932 Acyl-CoA dehydrogenase (ACAD) 10 and 11, N-terminal domain, and similar proteins. This subfamily is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: ACAD10_11_like; cd05154 114615007933 putative active site [active] 114615007934 putative substrate binding site [chemical binding]; other site 114615007935 ATP binding site [chemical binding]; other site 114615007936 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK05565 114615007937 classical (c) SDRs; Region: SDR_c; cd05233 114615007938 NAD(P) binding site [chemical binding]; other site 114615007939 active site 114615007940 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 114615007941 Histidine phosphatase superfamily (branch 1); Region: His_Phos_1; pfam00300 114615007942 catalytic core [active] 114615007943 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 114615007944 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK05565 114615007945 NAD(P) binding site [chemical binding]; other site 114615007946 active site 114615007947 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 114615007948 Beta-lactamase; Region: Beta-lactamase; cl01009 114615007949 ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683 114615007950 Periplasmic solute-binding domain of active transport proteins that belong to the type I periplasmic binding fold protein family; Region: PBP1_SBP_like_1; cd06327 114615007951 putative ligand binding site [chemical binding]; other site 114615007952 SecE/Sec61-gamma subunits of protein translocation complex; Region: SecE; cl00481 114615007953 transcription antitermination protein NusG; Validated; Region: nusG; PRK05609 114615007954 Bacterial N-Utilization Substance G (NusG) N-terminal (NGN) domain, subgroup 1; Region: NGN_Bact_1; cd09891 114615007955 putative homodimer interface [polypeptide binding]; other site 114615007956 KOW motif; Region: KOW; cl00354 114615007957 50S ribosomal protein L11; Validated; Region: rplK; PRK00140 114615007958 Ribosomal protein L11. Ribosomal protein L11, together with proteins L10 and L7/L12, and 23S rRNA, form the L7/L12 stalk on the surface of the large subunit of the ribosome. The homologous eukaryotic cytoplasmic protein is also called 60S ribosomal...; Region: Ribosomal_L11; cd00349 114615007959 23S rRNA interface [nucleotide binding]; other site 114615007960 L7/L12 interface [polypeptide binding]; other site 114615007961 putative thiostrepton binding site; other site 114615007962 L25 interface [polypeptide binding]; other site 114615007963 Ribosomal protein L1. The L1 protein, located near the E-site of the ribosome, forms part of the L1 stalk along with 23S rRNA. In bacteria and archaea, L1 functions both as a ribosomal protein that binds rRNA, and as a translation repressor that...; Region: Ribosomal_L1; cd00403 114615007964 mRNA/rRNA interface [nucleotide binding]; other site 114615007965 Lactate dehydrogenase and related dehydrogenases [Energy production and conversion / Coenzyme metabolism / General function prediction only]; Region: LdhA; COG1052 114615007966 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 114615007967 Ribosomal protein L10 family, L10 subfamily; composed of bacterial 50S ribosomal protein and eukaryotic mitochondrial 39S ribosomal protein, L10. L10 occupies the L7/L12 stalk of the ribosome. The N-terminal domain (NTD) of L10 interacts with L11...; Region: Ribosomal_L10; cd05797 114615007968 23S rRNA interface [nucleotide binding]; other site 114615007969 Interface with L7/L12 ribosomal proteins [polypeptide binding]; other site 114615007970 Ribosomal protein L7/L12. Ribosomal protein L7/L12 refers to the large ribosomal subunit proteins L7 and L12, which are identical except that L7 is acetylated at the N terminus. It is a component of the L7/L12 stalk, which is located at the surface of...; Region: Ribosomal_L7_L12; cd00387 114615007971 L11 interface [polypeptide binding]; other site 114615007972 putative EF-Tu interaction site [polypeptide binding]; other site 114615007973 putative EF-G interaction site [polypeptide binding]; other site 114615007974 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cl04593 114615007975 DNA-directed RNA polymerase subunit beta'; Provisional; Region: PRK00566 114615007976 RNA polymerase beta subunit; Region: RNA_pol_Rpb2_1; cl04591 114615007977 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653 114615007978 RPB11 interaction site [polypeptide binding]; other site 114615007979 RPB12 interaction site [polypeptide binding]; other site 114615007980 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653 114615007981 RPB3 interaction site [polypeptide binding]; other site 114615007982 RPB1 interaction site [polypeptide binding]; other site 114615007983 RPB11 interaction site [polypeptide binding]; other site 114615007984 RPB10 interaction site [polypeptide binding]; other site 114615007985 RNA polymerase Rpb1, domain 1; Region: RNA_pol_Rpb1_1; pfam04997 114615007986 DNA-directed RNA polymerase, beta' subunit/160 kD subunit [Transcription]; Region: RpoC; COG0086 114615007987 RNA polymerase Rpb1, domain 2; Region: RNA_pol_Rpb1_2; cl11591 114615007988 RNA polymerase Rpb1, domain 3; Region: RNA_pol_Rpb1_3; pfam04983 114615007989 RNA polymerase Rpb1, domain 4; Region: RNA_pol_Rpb1_4; pfam05000 114615007990 DNA-directed RNA polymerase subunit A''; Provisional; Region: PRK14898 114615007991 Largest subunit of RNA polymerase (RNAP), C-terminal domain; Region: RNAP_largest_subunit_C; cl11429 114615007992 Rpb1 - Rpb6 interaction site [polypeptide binding]; other site 114615007993 bifunctional DNA-directed RNA polymerase subunit beta/beta'; Reviewed; Region: PRK09603 114615007994 Largest subunit of RNA polymerase (RNAP), C-terminal domain; Region: RNAP_largest_subunit_C; cl11429 114615007995 Largest subunit (beta') of Bacterial DNA-dependent RNA polymerase (RNAP), C-terminal domain; Region: RNAP_beta'_C; cd02655 114615007996 DNA binding site [nucleotide binding] 114615007997 Rpb1 (beta') - Rpb2 (beta) interaction site [polypeptide binding]; other site 114615007998 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 114615007999 Flavin containing amine oxidoreductase; Region: Amino_oxidase; pfam01593 114615008000 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cl12011 114615008001 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 114615008002 ABC transporter transmembrane region; Region: ABC_membrane; cl00549 114615008003 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 114615008004 Walker A/P-loop; other site 114615008005 ATP binding site [chemical binding]; other site 114615008006 Q-loop/lid; other site 114615008007 ABC transporter signature motif; other site 114615008008 Walker B; other site 114615008009 D-loop; other site 114615008010 H-loop/switch region; other site 114615008011 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases [Coenzyme metabolism / Energy production and conversion]; Region: UbiH; COG0654 114615008012 Transposase domain (DUF772); Region: DUF772; cl12084 114615008013 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 114615008014 S12-like family, 30S ribosomal protein S12 subfamily; S12 is located at the interface of the large and small ribosomal subunits of prokaryotes, chloroplasts and mitochondria, where it plays an important role in both tRNA and ribosomal subunit...; Region: Ribosomal_S12; cd03368 114615008015 S17 interaction site [polypeptide binding]; other site 114615008016 S8 interaction site; other site 114615008017 16S rRNA interaction site [nucleotide binding]; other site 114615008018 streptomycin interaction site [chemical binding]; other site 114615008019 23S rRNA interaction site [nucleotide binding]; other site 114615008020 aminoacyl-tRNA interaction site (A-site) [nucleotide binding]; other site 114615008021 Ribosomal protein S7p/S5e; Region: Ribosomal_S7; cl00313 114615008022 elongation factor G; Reviewed; Region: PRK00007 114615008023 Elongation factor G (EF-G) subfamily. Translocation is mediated by EF-G (also called translocase). The structure of EF-G closely resembles that of the complex between EF-Tu and tRNA. This is an example of molecular mimicry; a protein domain evolved...; Region: EF-G; cd01886 114615008024 G1 box; other site 114615008025 putative GEF interaction site [polypeptide binding]; other site 114615008026 GTP/Mg2+ binding site [chemical binding]; other site 114615008027 Switch I region; other site 114615008028 G2 box; other site 114615008029 G3 box; other site 114615008030 Switch II region; other site 114615008031 G4 box; other site 114615008032 G5 box; other site 114615008033 EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide...; Region: EFG_mtEFG_II; cd04088 114615008034 EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor...; Region: EFG_mtEFG1_IV; cd01434 114615008035 EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G. Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor...; Region: EFG_mtEFG_C; cd03713 114615008036 elongation factor Tu; Reviewed; Region: PRK00049 114615008037 EF-Tu subfamily. This subfamily includes orthologs of translation elongation factor EF-Tu in bacteria, mitochondria, and chloroplasts. It is one of several GTP-binding translation factors found in the larger family of GTP-binding elongation factors; Region: EF_Tu; cd01884 114615008038 G1 box; other site 114615008039 GEF interaction site [polypeptide binding]; other site 114615008040 GTP/Mg2+ binding site [chemical binding]; other site 114615008041 Switch I region; other site 114615008042 G2 box; other site 114615008043 G3 box; other site 114615008044 Switch II region; other site 114615008045 G4 box; other site 114615008046 G5 box; other site 114615008047 EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697 114615008048 Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts)...; Region: EFTU_III; cd03707 114615008049 Antibiotic Binding Site [chemical binding]; other site 114615008050 Ribosomal protein S10p/S20e; Region: Ribosomal_S10; cl00314 114615008051 Ribosomal protein L3; Region: Ribosomal_L3; cl00324 114615008052 Ribosomal protein L4/L1 family; Region: Ribosomal_L4; cl00325 114615008053 Ribosomal protein L23; Region: Ribosomal_L23; cl00326 114615008054 50S ribosomal protein L2; Validated; Region: rplB; PRK09374 114615008055 Ribosomal Proteins L2, RNA binding domain; Region: Ribosomal_L2; pfam00181 114615008056 Ribosomal Proteins L2, C-terminal domain; Region: Ribosomal_L2_C; pfam03947 114615008057 Ribosomal protein S19; Region: Ribosomal_S19; cl00350 114615008058 Ribosomal protein L22/L17e. L22 (L17 in eukaryotes) is a core protein of the large ribosomal subunit. It is the only ribosomal protein that interacts with all six domains of 23S rRNA, and is one of the proteins important for directing the proper...; Region: Ribosomal_L22; cd00336 114615008059 protein-rRNA interface [nucleotide binding]; other site 114615008060 putative translocon binding site; other site 114615008061 30S ribosomal protein S3; Reviewed; Region: rpsC; PRK00310 114615008062 K homology RNA-binding (KH) domain of the prokaryotic 30S small ribosomal subunit protein S3. S3 is part of the head region of the 30S ribosomal subunit and is believed to interact with mRNA as it threads its way from the latch into the channel. The...; Region: 30S_S3_KH; cd02412 114615008063 G-X-X-G motif; other site 114615008064 Ribosomal protein S3, C-terminal domain; Region: Ribosomal_S3_C; pfam00189 114615008065 Ribosomal_L16_L10e: L16 is an essential protein in the large ribosomal subunit of bacteria, mitochondria, and chloroplasts. Large subunits that lack L16 are defective in peptidyl transferase activity, peptidyl-tRNA hydrolysis activity, association with...; Region: Ribosomal_L16_L10e; cd01433 114615008066 23S rRNA interface [nucleotide binding]; other site 114615008067 5S rRNA interface [nucleotide binding]; other site 114615008068 putative antibiotic binding site [chemical binding]; other site 114615008069 L25 interface [polypeptide binding]; other site 114615008070 L27 interface [polypeptide binding]; other site 114615008071 Ribosomal L29 protein/HIP. L29 is a protein of the large ribosomal Subunit. A homolog, called heparin/heparan sulfate interacting protein (HIP), has also been identified in mammals. L29 is located on the surface of the large ribosomal subunit, where...; Region: Ribosomal_L29_HIP; cd00427 114615008072 putative translocon interaction site; other site 114615008073 signal recognition particle (SRP54) interaction site; other site 114615008074 L23 interface [polypeptide binding]; other site 114615008075 trigger factor interaction site; other site 114615008076 23S rRNA interface [nucleotide binding]; other site 114615008077 Ribosomal protein S17; Region: Ribosomal_S17; cl00351 114615008078 Ribosomal protein L14p/L23e; Region: Ribosomal_L14; cl00328 114615008079 KOW motif; Region: KOW; cl00354 114615008080 50S ribosomal protein L5; Validated; Region: rplE; PRK00010 114615008081 Ribosomal protein L5; Region: Ribosomal_L5; pfam00281 114615008082 ribosomal L5P family C-terminus; Region: Ribosomal_L5_C; pfam00673 114615008083 Ribosomal protein S14p/S29e; Region: Ribosomal_S14; cl00355 114615008084 Ribosomal protein S8; Region: Ribosomal_S8; cl00330 114615008085 50S ribosomal protein L6; Validated; Region: rplF; PRK05498 114615008086 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 114615008087 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 114615008088 Ribosomal L18/L5e: L18 (L5e) is a ribosomal protein found in the central protuberance (CP) of the large subunit. L18 binds 5S rRNA and induces a conformational change that stimulates the binding of L5 to 5S rRNA. Association of 5S rRNA with 23S rRNA...; Region: Ribosomal_L18_L5e; cd00432 114615008089 5S rRNA interface [nucleotide binding]; other site 114615008090 23S rRNA interface [nucleotide binding]; other site 114615008091 L5 interface [polypeptide binding]; other site 114615008092 30S ribosomal protein S5; Validated; Region: rpsE; PRK00550 114615008093 Ribosomal protein S5, N-terminal domain; Region: Ribosomal_S5; pfam00333 114615008094 Ribosomal protein S5, C-terminal domain; Region: Ribosomal_S5_C; pfam03719 114615008095 Ribosomal protein L30, which is found in eukaryotes and prokaryotes but not in archaea, is one of the smallest ribosomal proteins with a molecular mass of about 7kDa. L30 binds the 23SrRNA as well as the 5S rRNA and is one of five ribosomal proteins...; Region: Ribosomal_L30; cd01658 114615008096 23S rRNA binding site [nucleotide binding]; other site 114615008097 Ribosomal protein L18e/L15; Region: Ribosomal_L18e; cl12022 114615008098 preprotein translocase subunit SecY; Reviewed; Region: secY; PRK09204 114615008099 SecY translocase; Region: SecY; pfam00344 114615008100 adenylate kinase; Reviewed; Region: adk; PRK00279 114615008101 Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for...; Region: ADK; cd01428 114615008102 AMP-binding site [chemical binding]; other site 114615008103 ATP-AMP (Ap5A)-binding site [chemical binding]; other site 114615008104 Ribosomal protein S13/S18; Region: Ribosomal_S13; cl00331 114615008105 Ribosomal protein S13 [Translation, ribosomal structure and biogenesis]; Region: RpsM; COG0099 114615008106 Ribosomal protein S11; Region: Ribosomal_S11; cl00332 114615008107 DNA-directed RNA polymerase subunit alpha; Provisional; Region: PRK05182 114615008108 N-terminal domain of the Alpha subunit of Bacterial RNA polymerase; Region: RNAP_alpha_NTD; cd06928 114615008109 alphaNTD - beta interaction site [polypeptide binding]; other site 114615008110 alphaNTD homodimer interface [polypeptide binding]; other site 114615008111 alphaNTD - beta' interaction site [polypeptide binding]; other site 114615008112 Bacterial RNA polymerase, alpha chain C terminal domain; Region: RNA_pol_A_CTD; cl11613 114615008113 Ribosomal protein L17; Region: Ribosomal_L17; cl00356 114615008114 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 114615008115 classical (c) SDRs; Region: SDR_c; cd05233 114615008116 NAD(P) binding site [chemical binding]; other site 114615008117 active site 114615008118 Protein of unknown function (DUF1330); Region: DUF1330; cl02288 114615008119 ClC chloride channel family. These protein sequences, closely related to the ClC Eric family, are putative halogen ion (Cl-, Br- and I-) transport proteins found in eubacteria. They belong to the ClC superfamily of chloride ion channels, which share a...; Region: EriC_like; cd01034 114615008120 Voltage gated chloride channel; Region: Voltage_CLC; pfam00654 114615008121 putative ion selectivity filter; other site 114615008122 putative pore gating glutamate residue; other site 114615008123 putative H+/Cl- coupling transport residue; other site 114615008124 NMT1/THI5 like; Region: NMT1; pfam09084 114615008125 Tripartite tricarboxylate transporter family receptor; Region: TctC; cl15260 114615008126 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261 114615008127 dimer interface [polypeptide binding]; other site 114615008128 conserved gate region; other site 114615008129 putative PBP binding loops; other site 114615008130 ABC-ATPase subunit interface; other site 114615008131 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 114615008132 NrtD and SsuB are the ATP-binding subunits of the bacterial ABC-type nitrate and sulfonate transport systems, respectively. ABC transporters are a large family of proteins involved in the transport of a wide variety of different compounds, like sugars...; Region: ABC_NrtD_SsuB_transporters; cd03293 114615008133 Walker A/P-loop; other site 114615008134 ATP binding site [chemical binding]; other site 114615008135 Q-loop/lid; other site 114615008136 ABC transporter signature motif; other site 114615008137 Walker B; other site 114615008138 D-loop; other site 114615008139 H-loop/switch region; other site 114615008140 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have...; Region: metallo-dependent_hydrolases; cl00281 114615008141 Cytosine deaminase and related metal-dependent hydrolases [Nucleotide transport and metabolism / General function prediction only]; Region: SsnA; COG0402 114615008142 active site 114615008143 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 114615008144 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 114615008145 NAD(P) binding site [chemical binding]; other site 114615008146 active site 114615008147 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK05565 114615008148 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 114615008149 NAD(P) binding site [chemical binding]; other site 114615008150 active site 114615008151 dihydroxy-acid dehydratase; Provisional; Region: PRK13017 114615008152 Dehydratase family; Region: ILVD_EDD; cl00340 114615008153 Transcriptional regulators [Transcription]; Region: PurR; COG1609 114615008154 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 114615008155 DNA binding site [nucleotide binding] 114615008156 domain linker motif; other site 114615008157 Ligand-binding domain of DNA transcription repressor GntR specific for gluconate, a member of the LacI-GalR family of bacterial transcription regulators; Region: PBP1_GntR; cd01575 114615008158 putative dimerization interface [polypeptide binding]; other site 114615008159 putative ligand binding site [chemical binding]; other site 114615008160 glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650 114615008161 The N-terminal ATPase domain of the maltose transporter, MalK. ATP binding cassette (ABC) proteins function from bacteria to human, mediating the translocation of substances into and out of cells or organelles. ABC transporters contain two...; Region: ABC_MalK_N; cd03301 114615008162 Walker A/P-loop; other site 114615008163 ATP binding site [chemical binding]; other site 114615008164 Q-loop/lid; other site 114615008165 ABC transporter signature motif; other site 114615008166 Walker B; other site 114615008167 D-loop; other site 114615008168 H-loop/switch region; other site 114615008169 TOBE domain; Region: TOBE_2; cl01440 114615008170 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 114615008171 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261 114615008172 dimer interface [polypeptide binding]; other site 114615008173 conserved gate region; other site 114615008174 putative PBP binding loops; other site 114615008175 ABC-ATPase subunit interface; other site 114615008176 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 114615008177 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261 114615008178 dimer interface [polypeptide binding]; other site 114615008179 conserved gate region; other site 114615008180 putative PBP binding loops; other site 114615008181 ABC-ATPase subunit interface; other site 114615008182 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 114615008183 Escherichia coli Gne (a nucleoside-diphosphate-sugar 4-epimerase)-like, extended (e) SDRs; Region: Gne_like_SDR_e; cd05238 114615008184 putative NAD(P) binding site [chemical binding]; other site 114615008185 active site 114615008186 putative substrate binding site [chemical binding]; other site 114615008187 acetyl-CoA acetyltransferase; Provisional; Region: PRK07516 114615008188 Thiolase domain associated with sterol carrier protein (SCP)-x isoform and related proteins; SCP-2 has multiple roles in intracellular lipid circulation and metabolism. The N-terminal presequence in the SCP-x isoform represents a peroxisomal 3-ketacyl-; Region: SCP-x_thiolase; cd00829 114615008189 active site 114615008190 ATP-dependent Lon protease, bacterial type [Posttranslational modification, protein turnover, chaperones]; Region: Lon; COG0466 114615008191 Found in ATP-dependent protease La (LON); Region: LON; smart00464 114615008192 ATP-dependent Clp protease ATP-binding subunit clpA; Region: ClpA; TIGR02639 114615008193 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 114615008194 DinB superfamily; Region: DinB_2; cl00986 114615008195 Catalase-like heme-binding proteins similar to the uncharacterized y4iL; Region: y4iL_like; cd08152 114615008196 putative heme binding pocket [chemical binding]; other site 114615008197 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase...; Region: trans_reg_C; cd00383 114615008198 DNA binding site [nucleotide binding] 114615008199 Predicted ATPase [General function prediction only]; Region: COG3899 114615008200 Membrane transport protein; Region: Mem_trans; cl09117 114615008201 Glutathione-dependent formaldehyde-activating enzyme; Region: GFA; cl01553 114615008202 CoA-transferase family III; Region: CoA_transf_3; cl00778 114615008203 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 114615008204 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 114615008205 active site 114615008206 thiolase; Provisional; Region: PRK06158 114615008207 Thiolase domain associated with sterol carrier protein (SCP)-x isoform and related proteins; SCP-2 has multiple roles in intracellular lipid circulation and metabolism. The N-terminal presequence in the SCP-x isoform represents a peroxisomal 3-ketacyl-; Region: SCP-x_thiolase; cd00829 114615008208 active site 114615008209 DUF35 OB-fold domain; Region: DUF35; pfam01796 114615008210 Glutaminase; Region: Glutaminase; cl00907 114615008211 Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function; Region: STAS_SulP_like_sulfate_transporter; cd07042 114615008212 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 114615008213 ligand binding site [chemical binding]; other site 114615008214 flexible hinge region; other site 114615008215 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 114615008216 Transcriptional regulator [Transcription]; Region: IclR; COG1414 114615008217 Bacterial transcriptional regulator; Region: IclR; pfam01614 114615008218 Acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta) [Lipid metabolism]; Region: COG4799 114615008219 Acetyl co-enzyme A carboxylase carboxyltransferase alpha subunit; Region: ACCA; cl00513 114615008220 Acetyl co-enzyme A carboxylase carboxyltransferase alpha subunit; Region: ACCA; cl00513 114615008221 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 114615008222 Major Facilitator Superfamily; Region: MFS_1; pfam07690 114615008223 putative substrate translocation pore; other site 114615008224 acetyl-CoA acetyltransferase; Provisional; Region: PRK06954 114615008225 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 114615008226 dimer interface [polypeptide binding]; other site 114615008227 active site 114615008228 enoyl-CoA hydratase; Provisional; Region: PRK06143 114615008229 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase...; Region: crotonase-like; cd06558 114615008230 substrate binding site [chemical binding]; other site 114615008231 oxyanion hole (OAH) forming residues; other site 114615008232 trimer interface [polypeptide binding]; other site 114615008233 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 114615008234 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 114615008235 Methylmalonate semialdehyde dehydrogenase and ALDH family members 6A1 and 6B2; Region: ALDH_F6_MMSDH; cd07085 114615008236 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 114615008237 tetrameric interface [polypeptide binding]; other site 114615008238 NAD binding site [chemical binding]; other site 114615008239 catalytic residues [active] 114615008240 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 114615008241 Isobutyryl-CoA dehydrogenase; Region: IBD; cd01162 114615008242 substrate binding pocket [chemical binding]; other site 114615008243 FAD binding site [chemical binding]; other site 114615008244 catalytic base [active] 114615008245 3-hydroxyisobutyryl-CoA hydrolase; Provisional; Region: PRK05617 114615008246 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase...; Region: crotonase-like; cd06558 114615008247 substrate binding site [chemical binding]; other site 114615008248 oxyanion hole (OAH) forming residues; other site 114615008249 trimer interface [polypeptide binding]; other site 114615008250 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 114615008251 3-hydroxyisobutyrate dehydrogenase; Region: HIBADH; TIGR01692 114615008252 Acyl-coenzyme A synthetases/AMP-(fatty) acid ligases [Lipid metabolism]; Region: Acs; COG0365 114615008253 Acyl-protein synthetase, LuxE; Region: LuxE; cl10450 114615008254 NodN (nodulation factor N) contains a single hot dog fold similar to those of the peroxisomal Hydratase-Dehydrogenase-Epimerase (HDE) protein, and the fatty acid synthase beta subunit. Rhizobium and related species form nodules on the roots of their...; Region: NodN; cd03450 114615008255 putative active site [active] 114615008256 putative catalytic site [active] 114615008257 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 114615008258 (3R)-hydroxyacyl-CoA dehydrogenase-like, classical(c)-like SDRs; Region: hydroxyacyl-CoA-like_DH_SDR_c-like; cd05353 114615008259 NAD binding site [chemical binding]; other site 114615008260 homodimer interface [polypeptide binding]; other site 114615008261 active site 114615008262 Predicted flavoproteins [General function prediction only]; Region: COG2081 114615008263 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 114615008264 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 114615008265 Predicted amino acid aldolase or racemase [Amino acid transport and metabolism]; Region: COG3616 114615008266 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes, Low Specificity D-Threonine Aldolase-like; Region: PLPDE_III_LS_D-TA_like; cd06820 114615008267 dimer interface [polypeptide binding]; other site 114615008268 active site 114615008269 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 114615008270 substrate binding site [chemical binding]; other site 114615008271 catalytic residue [active] 114615008272 ABC transporter ATPase component; Reviewed; Region: PRK11147 114615008273 ABCF_EF-3 Elongation factor 3 (EF-3) is a cytosolic protein required by fungal ribosomes for in vitro protein synthesis and for in vivo growth. EF-3 stimulates the binding of the EF-1: GTP: aa-tRNA ternary complex to the ribosomal A site by...; Region: ABCF_EF-3; cd03221 114615008274 ABCF_EF-3 Elongation factor 3 (EF-3) is a cytosolic protein required by fungal ribosomes for in vitro protein synthesis and for in vivo growth. EF-3 stimulates the binding of the EF-1: GTP: aa-tRNA ternary complex to the ribosomal A site by...; Region: ABCF_EF-3; cd03221 114615008275 Uncharacterized BCR, YaiI/YqxD family COG1671; Region: DUF188; cl00727 114615008276 Aerobic-type carbon monoxide dehydrogenase, large subunit CoxL/CutL homologs [Energy production and conversion]; Region: CoxL; COG1529 114615008277 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; cl03161 114615008278 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 114615008279 exopolyphosphatase; Region: exo_poly_only; TIGR03706 114615008280 Ppx/GppA phosphatase family; Region: Ppx-GppA; pfam02541 114615008281 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cd02440 114615008282 S-adenosylmethionine binding site [chemical binding]; other site 114615008283 Protein of unknown function (DUF3551); Region: DUF3551; pfam12071 114615008284 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3181 114615008285 Tripartite tricarboxylate transporter family receptor; Region: TctC; cl15260 114615008286 Tripartite tricarboxylate transporter TctB family; Region: TctB; pfam07331 114615008287 Tripartite tricarboxylate transporter TctA family; Region: TctA; cl00772 114615008288 Highly conserved protein containing a thioredoxin domain [Posttranslational modification, protein turnover, chaperones]; Region: COG1331 114615008289 Protein of unknown function (DUF1003); Region: DUF1003; cl01831 114615008290 Aerobic-type carbon monoxide dehydrogenase, large subunit CoxL/CutL homologs [Energy production and conversion]; Region: CoxL; COG1529 114615008291 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 114615008292 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; cl03161 114615008293 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 114615008294 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 114615008295 Aerobic-type carbon monoxide dehydrogenase, small subunit CoxS/CutS homologs [Energy production and conversion]; Region: CoxS; COG2080 114615008296 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cl00159 114615008297 [2Fe-2S] binding domain; Region: Fer2_2; pfam01799 114615008298 Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010 114615008299 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 114615008300 putative transporter; Provisional; Region: PRK10504 114615008301 putative substrate translocation pore; other site 114615008302 inosine 5'-monophosphate dehydrogenase; Reviewed; Region: PRK05567 114615008303 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl09108 114615008304 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in the inosine 5' monophosphate dehydrogenase (IMPDH) protein. IMPDH is an essential enzyme that catalyzes the first step unique to GTP synthesis, playing a key...; Region: CBS_pair_IMPDH; cd04601 114615008305 IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of the...; Region: IMPDH; cd00381 114615008306 active site 114615008307 Putative NADP-dependent oxidoreductases [General function prediction only]; Region: COG2130 114615008308 Prostaglandin dehydrogenases; Region: PGDH; cd05288 114615008309 NAD(P) binding site [chemical binding]; other site 114615008310 substrate binding site [chemical binding]; other site 114615008311 dimer interface [polypeptide binding]; other site 114615008312 MAPEG family; Region: MAPEG; cl09190 114615008313 tRNA and rRNA cytosine-C5-methylases [Translation, ribosomal structure and biogenesis]; Region: Sun; COG0144 114615008314 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cl12011 114615008315 GMP synthase; Reviewed; Region: guaA; PRK00074 114615008316 Type 1 glutamine amidotransferase (GATase1) domain found in GMP synthetase; Region: GATase1_GMP_Synthase; cd01742 114615008317 AMP/PPi binding site [chemical binding]; other site 114615008318 candidate oxyanion hole; other site 114615008319 catalytic triad [active] 114615008320 potential glutamine specificity residues [chemical binding]; other site 114615008321 The C-terminal domain of GMP synthetase. It contains two subdomains; the ATP pyrophosphatase domain which closes to the N-termial and the dimerization domain at C-terminal end. The ATP-PPase is a twisted, five-stranded parallel beta-sheet sandwiched...; Region: GMP_synthase_C; cd01997 114615008322 ATP Binding subdomain [chemical binding]; other site 114615008323 Ligand Binding sites [chemical binding]; other site 114615008324 Dimerization subdomain; other site 114615008325 YcfA-like protein; Region: YcfA; cl00752 114615008326 putative inner membrane protein; Provisional; Region: PRK11099 114615008327 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 114615008328 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 114615008329 Cytochrome C biogenesis protein transmembrane region; Region: DsbD; cl00515 114615008330 SoxW family; SoxW is a bacterial periplasmic TRX, containing a redox active CXXC motif, encoded by a genetic locus (sox operon) involved in thiosulfate oxidation. Sulfur bacteria oxidize sulfur compounds to provide reducing equivalents for carbon...; Region: SoxW; cd02951 114615008331 catalytic residues [active] 114615008332 Cytochrome c; Region: Cytochrom_C; cl11414 114615008333 Predicted secreted protein [Function unknown]; Region: COG5501; cl02313 114615008334 Sulphur oxidation protein SoxZ; Region: SoxZ; pfam08770 114615008335 Cytochrome c [Energy production and conversion]; Region: COG3258 114615008336 Cytochrome c [Energy production and conversion]; Region: COG3258 114615008337 Thermus thermophilus SoxB and related proteins, N-terminal metallophosphatase domain; Region: MPP_SoxB_N; cd07411 114615008338 active site 114615008339 metal binding site [ion binding]; metal-binding site 114615008340 5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872 114615008341 bacterial SoxC is a member of the sulfite oxidase (SO) family of molybdopterin binding domains. SoxC is involved in oxidation of sulfur compounds during chemolithothrophic growth. Together with SoxD, a small c-type heme containing subunit, it forms a...; Region: bact_SoxC_Moco; cd02113 114615008342 Moco binding site; other site 114615008343 metal coordination site [ion binding]; other site 114615008344 dimerization interface [polypeptide binding]; other site 114615008345 Cytochrome c; Region: Cytochrom_C; cl11414 114615008346 DsrE/DsrF-like family; Region: DrsE; cl00672 114615008347 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 114615008348 DsrE/DsrF-like family; Region: DrsE; cl00672 114615008349 Lyase class I_like superfamily: contains the lyase class I family, histidine ammonia-lyase and phenylalanine ammonia-lyase, which catalyze similar beta-elimination reactions; Region: Lyase_I_like; cl00013 114615008350 putative inner membrane protein; Provisional; Region: PRK11099 114615008351 YeeE/YedE family (DUF395); Region: DUF395; cl01018 114615008352 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 114615008353 active site residue [active] 114615008354 DsbA family, Com1-like subfamily; composed of proteins similar to Com1, a 27-kDa outer membrane-associated immunoreactive protein originally found in both acute and chronic disease strains of the pathogenic bacteria Coxiella burnetti. It contains a...; Region: DsbA_Com1_like; cd03023 114615008355 DSBA-like thioredoxin domain; Region: DSBA; pfam01323 114615008356 catalytic residues [active] 114615008357 Uncharacterized protein predicted to be involved in C-type cytochrome biogenesis [Posttranslational modification, protein turnover, chaperones / Energy production and conversion]; Region: COG4233 114615008358 Thiol:disulfide interchange protein [Posttranslational modification, protein turnover, chaperones / Energy production and conversion]; Region: COG4232 114615008359 DsbD gamma family; DsbD gamma is the C-terminal periplasmic domain of the bacterial protein DsbD. It contains a CXXC motif in a TRX fold and shuttles the reducing potential from the membrane domain (DsbD beta) to the N-terminal periplasmic domain (DsbD...; Region: DsbDgamma; cd02953 114615008360 DsbD alpha interface [polypeptide binding]; other site 114615008361 catalytic residues [active] 114615008362 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 114615008363 Protein of unknown function (DUF2892); Region: DUF2892; pfam11127 114615008364 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 114615008365 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 114615008366 ligand binding site [chemical binding]; other site 114615008367 flexible hinge region; other site 114615008368 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 114615008369 Carboxymuconolactone decarboxylase family; Region: CMD; cl00460 114615008370 Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841 114615008371 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 114615008372 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 114615008373 dimerization interface [polypeptide binding]; other site 114615008374 putative DNA binding site [nucleotide binding]; other site 114615008375 putative Zn2+ binding site [ion binding]; other site 114615008376 Uncharacterized NAD(FAD)-dependent dehydrogenases [General function prediction only]; Region: HcaD; COG0446 114615008377 thioredoxin 2; Provisional; Region: PRK10996 114615008378 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 114615008379 catalytic residues [active] 114615008380 Protein of unknown function (DUF2892); Region: DUF2892; pfam11127 114615008381 cytochrome c oxidase accessory protein FixG; Region: ccoG_rdxA_fixG; TIGR02745 114615008382 4Fe-4S binding domain; Region: Fer4_5; pfam12801 114615008383 Ubp3 associated protein Bre5; Region: Bre5; pfam11614 114615008384 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes...; Region: AAA; cd00009 114615008385 Walker A motif; other site 114615008386 ATP binding site [chemical binding]; other site 114615008387 MoxR-like ATPases [General function prediction only]; Region: COG0714 114615008388 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 114615008389 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 114615008390 Bacteriophage P4 integrase. P4-like integrases are found in temperate bacteriophages, integrative plasmids, pathogenicity and symbiosis islands, and other mobile genetic elements. They share the same fold in their catalytic domain and the overall...; Region: INT_P4; cd00801 114615008391 active site 114615008392 Int/Topo IB signature motif; other site 114615008393 DNA photolyase; Region: DNA_photolyase; pfam00875 114615008394 FAD binding domain of DNA photolyase; Region: FAD_binding_7; pfam03441 114615008395 Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices connected by an extended linker. The...; Region: HAMP; cl01054 114615008396 Taxis toward Aspartate and Related amino acids and Homologs (TarH). The Tar chemoreceptor of Escherichia coli mediates attractant responses to aspartate, maltose, and phenol, repellent responses to Ni2+ and Co2+, and thermoresponses. These...; Region: TarH; cl00144 114615008397 DctM-like transporters; Region: DctM; pfam06808 114615008398 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl09110 114615008399 Tripartite ATP-independent periplasmic transporters, DctQ component; Region: DctQ; cl01181 114615008400 Bacterial extracellular solute-binding protein, family 7; Region: SBP_bac_7; cl00710 114615008401 N-methylhydantoinase B/acetone carboxylase, alpha subunit [Amino acid transport and metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: HyuB; COG0146 114615008402 N-methylhydantoinase A/acetone carboxylase, beta subunit [Amino acid transport and metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: HyuA; COG0145 114615008403 Hydantoinase/oxoprolinase N-terminal region; Region: Hydant_A_N; pfam05378 114615008404 Hydantoinase/oxoprolinase; Region: Hydantoinase_A; cl00668 114615008405 Protein of unknown function (DUF1428); Region: DUF1428; cl02319 114615008406 Superfamily II DNA and RNA helicases [DNA replication, recombination, and repair / Transcription / Translation, ribosomal structure and biogenesis]; Region: SrmB; COG0513 114615008407 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 114615008408 ATP binding site [chemical binding]; other site 114615008409 putative Mg++ binding site [ion binding]; other site 114615008410 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 114615008411 nucleotide binding region [chemical binding]; other site 114615008412 ATP-binding site [chemical binding]; other site 114615008413 DbpA RNA binding domain; Region: DbpA; pfam03880 114615008414 Predicted membrane protein (DUF2177); Region: DUF2177; cl02014 114615008415 Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450 114615008416 Peroxiredoxin (PRX) family, 1-cys PRX subfamily; composed of PRXs containing only one conserved cysteine, which serves as the peroxidatic cysteine. They are homodimeric thiol-specific antioxidant (TSA) proteins that confer a protective role in cells by...; Region: PRX_1cys; cd03016 114615008417 dimer interface [polypeptide binding]; other site 114615008418 decamer (pentamer of dimers) interface [polypeptide binding]; other site 114615008419 catalytic triad [active] 114615008420 Sulfatase; Region: Sulfatase; cl10460 114615008421 YciF bacterial stress response protein, ferritin-like iron-binding domain; Region: YciF; cd07909 114615008422 dimerization interface [polypeptide binding]; other site 114615008423 metal binding site [ion binding]; metal-binding site 114615008424 Anion permease ArsB. These permeases have been shown to export arsenate and antimonite in eubacteria and archaea. A typical ArsB permease contains 8-13 transmembrane helices and can function either independently as a chemiosmotic transporter or as a...; Region: ArsB_permease; cd01118 114615008425 transmembrane helices; other site 114615008426 Major Facilitator Superfamily; Region: MFS_1; pfam07690 114615008427 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 114615008428 Aminomethyltransferase folate-binding domain; Region: GCV_T; pfam01571 114615008429 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204 114615008430 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156 114615008431 active site 114615008432 phosphorylation site [posttranslational modification] 114615008433 intermolecular recognition site; other site 114615008434 dimerization interface [polypeptide binding]; other site 114615008435 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes...; Region: AAA; cd00009 114615008436 Walker A motif; other site 114615008437 ATP binding site [chemical binding]; other site 114615008438 Walker B motif; other site 114615008439 arginine finger; other site 114615008440 Bacterial regulatory protein, Fis family; Region: HTH_8; cl01091 114615008441 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via trans-...; Region: HisKA; cl00080 114615008442 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 114615008443 ATP binding site [chemical binding]; other site 114615008444 Mg2+ binding site [ion binding]; other site 114615008445 G-X-G motif; other site 114615008446 PAS fold; Region: PAS_3; pfam08447 114615008447 Motif C-terminal to PAS motifs (likely to contribute to PAS structural domain); Region: PAC; smart00086 114615008448 PAS domain S-box; Region: sensory_box; TIGR00229 114615008449 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 114615008450 putative active site [active] 114615008451 heme pocket [chemical binding]; other site 114615008452 Signal transduction histidine kinase, nitrogen specific [Signal transduction mechanisms]; Region: NtrB; COG3852 114615008453 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via trans-...; Region: HisKA; cd00082 114615008454 dimer interface [polypeptide binding]; other site 114615008455 phosphorylation site [posttranslational modification] 114615008456 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 114615008457 ATP binding site [chemical binding]; other site 114615008458 Mg2+ binding site [ion binding]; other site 114615008459 G-X-G motif; other site 114615008460 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 114615008461 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156 114615008462 active site 114615008463 phosphorylation site [posttranslational modification] 114615008464 intermolecular recognition site; other site 114615008465 dimerization interface [polypeptide binding]; other site 114615008466 Uncharacterized protein conserved in bacteria (DUF2248); Region: DUF2248; cl09206 114615008467 Acetyl/propionyl-CoA carboxylase, alpha subunit [Lipid metabolism]; Region: COG4770 114615008468 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 114615008469 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; cl03087 114615008470 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; cl08365 114615008471 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase...; Region: biotinyl_domain; cd06850 114615008472 carboxyltransferase (CT) interaction site; other site 114615008473 biotinylation site [posttranslational modification]; other site 114615008474 Members of the ICL/PEPM enzyme family catalyze either P-C or C-C bond formation/cleavage. Known members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate hydrolase (OAH), isocitrate...; Region: ICL_PEPM; cd00377 114615008475 tetramer interface [polypeptide binding]; other site 114615008476 active site 114615008477 Mg2+/Mn2+ binding site [ion binding]; other site 114615008478 Acylphosphatase; Region: Acylphosphatase; cl00551 114615008479 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cd02440 114615008480 S-adenosylmethionine binding site [chemical binding]; other site 114615008481 Predicted transcriptional regulators [Transcription]; Region: COG1510 114615008482 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 114615008483 atypical (a) SDRs, subgroup 8; Region: SDR_a8; cd05242 114615008484 TIGR01777 family protein; Region: yfcH 114615008485 putative NAD(P) binding site [chemical binding]; other site 114615008486 putative active site [active] 114615008487 DNA-binding transcriptional activator FeaR; Provisional; Region: PRK09685 114615008488 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 114615008489 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 114615008490 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 114615008491 4-Oxalocrotonate Tautomerase: Catalyzes the isomerization of unsaturated ketones. The structure is a homohexamer that is arranged as a trimer of dimers. The hexamer contains six active sites, each formed by residues from three monomers, two from one...; Region: 4Oxalocrotonate_Tautomerase; cl00235 114615008492 Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; cl14057 114615008493 site-specific tyrosine recombinase XerD; Reviewed; Region: xerD; PRK00283 114615008494 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 114615008495 Cytidine and deoxycytidylate deaminase zinc-binding region. The family contains cytidine deaminases, nucleoside deaminases, deoxycytidylate deaminases and riboflavin deaminases. Also included are the apoBec family of mRNA editing enzymes. All members...; Region: cytidine_deaminase-like; cl00269 114615008496 active site 114615008497 Zn binding site [ion binding]; other site 114615008498 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 114615008499 Major Facilitator Superfamily; Region: MFS_1; pfam07690 114615008500 putative substrate translocation pore; other site 114615008501 Protein of unknown function (DUF1398); Region: DUF1398; cl11576 114615008502 ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683 114615008503 Periplasmic solute-binding domain of active transport proteins that belong to the type I periplasmic binding fold protein family; Region: PBP1_SBP_like_1; cd06327 114615008504 putative ligand binding site [chemical binding]; other site 114615008505 Uncharacterized conserved protein [Function unknown]; Region: COG3391 114615008506 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 114615008507 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 114615008508 Protein of unknown function (DUF3313); Region: DUF3313; pfam11769 114615008509 Patatins and Phospholipases; Region: Patatin_and_cPLA2; cl11396 114615008510 active site 114615008511 nucleophile elbow; other site 114615008512 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: FabG; COG1028 114615008513 classical (c) SDRs; Region: SDR_c; cd05233 114615008514 NAD(P) binding site [chemical binding]; other site 114615008515 active site 114615008516 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 114615008517 amidophosphoribosyltransferase; Provisional; Region: PRK09123 114615008518 Glutamine amidotransferases class-II (GN-AT)_GPAT- type. This domain is found at the N-terminus of glutamine phosphoribosylpyrophosphate (Prpp) amidotransferase (GPATase) . The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the...; Region: GPATase_N; cd00715 114615008519 active site 114615008520 tetramer interface [polypeptide binding]; other site 114615008521 Phosphoribosyl transferase domain; Region: Pribosyltran; cl00309 114615008522 Colicin V production protein; Region: Colicin_V; cl00567 114615008523 DNA repair protein RadA; Provisional; Region: PRK11823 114615008524 Sms (bacterial radA) DNA repair protein. This protein is not related to archael radA any more than is to other RecA-like NTPases. Sms has a role in recombination and recombinational repair and is responsible for the stabilization or processing of...; Region: Sms; cd01121 114615008525 Walker A motif/ATP binding site; other site 114615008526 ATP binding site [chemical binding]; other site 114615008527 Walker B motif; other site 114615008528 Predicted permeases [General function prediction only]; Region: COG0730; cl00498 114615008529 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 114615008530 DNA-binding transcriptional activator FeaR; Provisional; Region: PRK09685 114615008531 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 114615008532 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 114615008533 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 114615008534 Escherichia coli exonuclease III (ExoIII) and Neisseria meningitides NExo-like subfamily of the ExoIII family purinic/apyrimidinic (AP) endonucleases; Region: ExoIII-like_AP-endo; cd09086 114615008535 putative phosphate binding site [ion binding]; other site 114615008536 putative catalytic site [active] 114615008537 active site 114615008538 metal binding site A [ion binding]; metal-binding site 114615008539 DNA binding site [nucleotide binding] 114615008540 putative AP binding site [nucleotide binding]; other site 114615008541 putative metal binding site B [ion binding]; other site 114615008542 Cysteine rich repeat; Region: Cys_rich_FGFR; pfam00839 114615008543 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 114615008544 Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300 114615008545 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 114615008546 NAD(P) binding site [chemical binding]; other site 114615008547 active site 114615008548 Lipocalin / cytosolic fatty-acid binding protein family; Region: Lipocalin; cl01150 114615008549 Threonyl-tRNA synthetase (ThrRS) class II core catalytic domain. ThrRS is a homodimer. It is responsible for the attachment of threonine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ThrRS_core; cd00771 114615008550 active site 114615008551 dimer interface [polypeptide binding]; other site 114615008552 motif 1; other site 114615008553 motif 2; other site 114615008554 motif 3; other site 114615008555 HGTP anticodon binding domain, as found at the C-terminus of histidyl, glycyl, threonyl and prolyl tRNA synthetases, which are classified as a group of class II aminoacyl-tRNA synthetases (aaRS). In aaRSs, the anticodon binding domain is responsible...; Region: HGTP_anticodon; cl00266 114615008556 anticodon binding site; other site 114615008557 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 114615008558 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 114615008559 Alanine racemase [Cell envelope biogenesis, outer membrane]; Region: Alr; COG0787 114615008560 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Alanine Racemase; Region: PLPDE_III_AR; cd00430 114615008561 active site 114615008562 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 114615008563 dimer interface [polypeptide binding]; other site 114615008564 substrate binding site [chemical binding]; other site 114615008565 catalytic residues [active] 114615008566 replicative DNA helicase; Provisional; Region: PRK09165 114615008567 DnaB-like helicase N terminal domain; Region: DnaB; pfam00772 114615008568 DnaB helicase C terminal domain. The hexameric helicase DnaB unwinds the DNA duplex at the chromosome replication fork. Although the mechanism by which DnaB both couples ATP hydrolysis to translocation along DNA and denatures the duplex is unknown, a...; Region: DnaB_C; cd00984 114615008569 Walker A motif; other site 114615008570 ATP binding site [chemical binding]; other site 114615008571 Walker B motif; other site 114615008572 DNA binding loops [nucleotide binding] 114615008573 Cyclopropane fatty acid synthase and related methyltransferases [Cell envelope biogenesis, outer membrane]; Region: Cfa; COG2230 114615008574 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cd02440 114615008575 S-adenosylmethionine binding site [chemical binding]; other site 114615008576 50S ribosomal protein L9; Reviewed; Region: rplI; PRK00137 114615008577 Ribosomal protein L9, N-terminal domain; Region: Ribosomal_L9_N; pfam01281 114615008578 Ribosomal protein L9, C-terminal domain; Region: Ribosomal_L9_C; pfam03948 114615008579 Ribosomal protein S18; Region: Ribosomal_S18; cl00373 114615008580 Ribosomal protein S6; Region: Ribosomal_S6; cl00414 114615008581 Acyl transferase domain; Region: Acyl_transf_1; cl08282 114615008582 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 114615008583 3-ketoacyl-(acyl-carrier-protein) reductase NodG; Reviewed; Region: PRK12936 114615008584 beta-Keto acyl carrier protein reductase (BKR), involved in Type II FAS, classical (c) SDRs; Region: BKR_SDR_c; cd05333 114615008585 NAD(P) binding site [chemical binding]; other site 114615008586 homotetramer interface [polypeptide binding]; other site 114615008587 homodimer interface [polypeptide binding]; other site 114615008588 active site 114615008589 Phosphopantetheine attachment site; Region: PP-binding; cl09936 114615008590 3-oxoacyl-(acyl carrier protein) synthase II; Reviewed; Region: PRK07314 114615008591 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 114615008592 dimer interface [polypeptide binding]; other site 114615008593 active site 114615008594 YceG-like family; Region: YceG; pfam02618 114615008595 proteins similar to Escherichia coli yceG; Region: yceG_like; cd08010 114615008596 dimerization interface [polypeptide binding]; other site 114615008597 hypothetical protein; Provisional; Region: PRK11820 114615008598 YicC-like family, N-terminal region; Region: YicC_N; pfam03755 114615008599 Domain of unknown function (DUF1732); Region: DUF1732; pfam08340 114615008600 Thymidylate kinase [Nucleotide transport and metabolism]; Region: Tmk; COG0125 114615008601 Guanosine monophosphate kinase (GMPK, EC 2.7.4.8), also known as guanylate kinase (GKase), catalyzes the reversible phosphoryl transfer from adenosine triphosphate (ATP) to guanosine monophosphate (GMP) to yield adenosine diphosphate (ADP) and...; Region: GMPK; cd00071 114615008602 catalytic site [active] 114615008603 G-X2-G-X-G-K; other site 114615008604 Caspase, interleukin-1 beta converting enzyme (ICE) homologues; Cysteine-dependent aspartate-directed proteases that mediate programmed cell death (apoptosis). Caspases are synthesized as inactive zymogens and activated by proteolysis of the peptide...; Region: CASc; cl00042 114615008605 Zn-dependent alcohol dehydrogenases [General function prediction only]; Region: AdhP; COG1064 114615008606 6-hydroxyhexanoate dehydrogenase; Region: 6_hydroxyhexanoate_dh_like; cd08240 114615008607 putative NAD(P) binding site [chemical binding]; other site 114615008608 catalytic Zn binding site [ion binding]; other site 114615008609 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cl12011 114615008610 Pyridoxal phosphate biosynthetic protein PdxA; Region: PdxA; cl00873 114615008611 4-hydroxythreonine-4-phosphate dehydrogenase; Validated; Region: pdxA; PRK03743 114615008612 SurA N-terminal domain; Region: SurA_N; pfam09312 114615008613 peptidyl-prolyl cis-trans isomerase SurA; Provisional; Region: PRK10770 114615008614 OstA-like protein; Region: OstA; cl00844 114615008615 Organic solvent tolerance protein OstA [Cell envelope biogenesis, outer membrane]; Region: Imp; COG1452 114615008616 Organic solvent tolerance protein; Region: OstA_C; pfam04453 114615008617 Predicted permeases [General function prediction only]; Region: COG0795; cl12074 114615008618 Predicted permease YjgP/YjgQ family; Region: YjgP_YjgQ; pfam03739 114615008619 Predicted permeases [General function prediction only]; Region: COG0795; cl12074 114615008620 Predicted permease YjgP/YjgQ family; Region: YjgP_YjgQ; pfam03739 114615008621 multifunctional aminopeptidase A; Provisional; Region: PRK00913 114615008622 Cytosol aminopeptidase family, N-terminal and catalytic domains. Family M17 contains zinc- and manganese-dependent exopeptidases ( EC 3.4.11.1), including leucine aminopeptidase. They catalyze removal of amino acids from the N-terminus of a protein...; Region: Peptidase_M17; cd00433 114615008623 interface (dimer of trimers) [polypeptide binding]; other site 114615008624 Substrate-binding/catalytic site; other site 114615008625 Zn-binding sites [ion binding]; other site 114615008626 DNA polymerase III chi subunit, HolC; Region: DNA_pol3_chi; cl01106 114615008627 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 114615008628 ABCF_EF-3 Elongation factor 3 (EF-3) is a cytosolic protein required by fungal ribosomes for in vitro protein synthesis and for in vivo growth. EF-3 stimulates the binding of the EF-1: GTP: aa-tRNA ternary complex to the ribosomal A site by...; Region: ABCF_EF-3; cd03221 114615008629 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 114615008630 ABCF_EF-3 Elongation factor 3 (EF-3) is a cytosolic protein required by fungal ribosomes for in vitro protein synthesis and for in vivo growth. EF-3 stimulates the binding of the EF-1: GTP: aa-tRNA ternary complex to the ribosomal A site by...; Region: ABCF_EF-3; cd03221 114615008631 ABC transporter; Region: ABC_tran_2; pfam12848 114615008632 ABCF_EF-3 Elongation factor 3 (EF-3) is a cytosolic protein required by fungal ribosomes for in vitro protein synthesis and for in vivo growth. EF-3 stimulates the binding of the EF-1: GTP: aa-tRNA ternary complex to the ribosomal A site by...; Region: ABCF_EF-3; cd03221 114615008633 Nucleoside diphosphate kinase Group I (NDPk_I)-like: NDP kinase domains are present in a large family of structurally and functionally conserved proteins from bacteria to humans that generally catalyze the transfer of gamma-phosphates of a nucleoside...; Region: NDPk_I; cd04413 114615008634 active site 114615008635 multimer interface [polypeptide binding]; other site 114615008636 Integral membrane protein TerC family; Region: TerC; cl10468 114615008637 AAK_UMPK-MosAB: This CD includes the alpha and beta subunits of the Mo storage protein (MosA and MosB) which are related to uridine monophosphate kinase (UMPK) enzymes that catalyze the phosphorylation of UMP by ATP, yielding UDP, and playing a key...; Region: AAK_UMPK-MosAB; cd04255 114615008638 putative nucleotide binding site [chemical binding]; other site 114615008639 putative substrate binding site [chemical binding]; other site 114615008640 AAK_UMPK-MosAB: This CD includes the alpha and beta subunits of the Mo storage protein (MosA and MosB) which are related to uridine monophosphate kinase (UMPK) enzymes that catalyze the phosphorylation of UMP by ATP, yielding UDP, and playing a key...; Region: AAK_UMPK-MosAB; cd04255 114615008641 putative nucleotide binding site [chemical binding]; other site 114615008642 putative substrate binding site [chemical binding]; other site 114615008643 exopolyphosphatase; Region: exo_poly_only; TIGR03706 114615008644 Ppx/GppA phosphatase family; Region: Ppx-GppA; pfam02541 114615008645 polyphosphate kinase; Provisional; Region: PRK05443 114615008646 Catalytic C-terminal domain, first repeat, of Pseudomonas aeruginosa polyphosphate kinase 1 and similar proteins; Region: PLDc_PaPPK1_C1_like; cd09165 114615008647 putative domain interface [polypeptide binding]; other site 114615008648 putative active site [active] 114615008649 catalytic site [active] 114615008650 Catalytic C-terminal domain, second repeat, of Pseudomonas aeruginosa polyphosphate kinase 1 and similar proteins; Region: PLDc_PaPPK1_C2_like; cd09168 114615008651 putative domain interface [polypeptide binding]; other site 114615008652 putative active site [active] 114615008653 catalytic site [active] 114615008654 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 114615008655 CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; cl00453 114615008656 phosphoribosylaminoimidazole synthetase; Provisional; Region: PRK05385 114615008657 PurM (Aminoimidazole Ribonucleotide [AIR] synthetase), one of eleven enzymes required for purine biosynthesis, catalyzes the conversion of formylglycinamide ribonucleotide (FGAM) and ATP to AIR, ADP, and Pi, the fifth step in de novo purine...; Region: PurM; cd02196 114615008658 dimerization interface [polypeptide binding]; other site 114615008659 putative ATP binding site [chemical binding]; other site 114615008660 phosphoribosylglycinamide formyltransferase; Reviewed; Region: purN; PRK05647 114615008661 Phosphoribosylglycinamide formyltransferase (GAR transformylase, GART); Region: FMT_core_GART; cd08645 114615008662 active site 114615008663 substrate binding site [chemical binding]; other site 114615008664 cosubstrate binding site; other site 114615008665 catalytic site [active] 114615008666 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box protein...; Region: CSP_CDS; cd04458 114615008667 DNA-binding site [nucleotide binding]; DNA binding site 114615008668 RNA-binding motif; other site 114615008669 Transcriptional regulator [Transcription]; Region: LysR; COG0583 114615008670 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 114615008671 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 114615008672 dimerization interface [polypeptide binding]; other site 114615008673 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 114615008674 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cl00220 114615008675 catalytic triad [active] 114615008676 conserved cis-peptide bond; other site 114615008677 DEDDy 3'-5' exonuclease domain of Ribonuclease D and similar proteins; Region: RNaseD_exo; cd06142 114615008678 ribonuclease D; Region: rnd; TIGR01388 114615008679 putative active site [active] 114615008680 catalytic site [active] 114615008681 putative substrate binding site [chemical binding]; other site 114615008682 HRDC domain; Region: HRDC; cl02578 114615008683 Uncharacterized conserved protein [Function unknown]; Region: COG0397; cl00428 114615008684 Uncharacterized ACR, YdiU/UPF0061 family; Region: UPF0061; pfam02696 114615008685 aspartyl-tRNA synthetase; Validated; Region: aspS; PRK00476 114615008686 EcAspRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli aspartyl-tRNA synthetase (AspRS), the human mitochondrial (mt) AspRS-2, the discriminating (D) Thermus thermophilus AspRS-1, and the nondiscriminating (ND)...; Region: EcAspRS_like_N; cd04317 114615008687 dimer interface [polypeptide binding]; other site 114615008688 anticodon binding site; other site 114615008689 Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of the...; Region: AspRS_core; cd00777 114615008690 homodimer interface [polypeptide binding]; other site 114615008691 motif 1; other site 114615008692 active site 114615008693 motif 2; other site 114615008694 GAD domain; Region: GAD; pfam02938 114615008695 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 114615008696 active site 114615008697 motif 3; other site 114615008698 Rare lipoprotein A (RlpA)-like double-psi beta-barrel; Region: DPBB_1; cl04011 114615008699 Fatty acid hydroxylase superfamily; Region: FA_hydroxylase; cl01132 114615008700 TadE-like protein; Region: TadE; pfam07811 114615008701 Flp pilus assembly protein TadG [Intracellular trafficking and secretion]; Region: TadG; COG4961 114615008702 bifunctional malic enzyme oxidoreductase/phosphotransacetylase; Reviewed; Region: PRK07232 114615008703 Malic enzyme, N-terminal domain; Region: malic; pfam00390 114615008704 NAD(P) binding domain of malic enzyme (ME), subgroup 2; Region: NAD_bind_2_malic_enz; cd05311 114615008705 putative NAD(P) binding site [chemical binding]; other site 114615008706 Phosphate acetyl/butaryl transferase; Region: PTA_PTB; cl00390 114615008707 DoxX; Region: DoxX; cl00976 114615008708 DoxX; Region: DoxX; cl00976 114615008709 Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5,10-...; Region: DHFR; cl00161 114615008710 folate binding site [chemical binding]; other site 114615008711 NADP+ binding site [chemical binding]; other site 114615008712 Polysaccharide deacetylase; Region: Polysacc_deac_1; cl12061 114615008713 Glutathione (GSH) peroxidase family; tetrameric selenoenzymes that catalyze the reduction of a variety of hydroperoxides including lipid peroxidases, using GSH as a specific electron donor substrate. GSH peroxidase contains one selenocysteine residue...; Region: GSH_Peroxidase; cd00340 114615008714 catalytic residues [active] 114615008715 dimer interface [polypeptide binding]; other site 114615008716 hypothetical protein; Provisional; Region: PRK06132 114615008717 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 114615008718 DNA polymerase III subunits gamma and tau; Validated; Region: PRK07003 114615008719 hypothetical protein; Provisional; Region: PRK06132 114615008720 CreA protein; Region: CreA; cl01154 114615008721 type I secretion system ABC transporter, PrtD family; Region: type_I_sec_PrtD; TIGR01842 114615008722 ABC transporter transmembrane region; Region: ABC_membrane; cl00549 114615008723 This family represents the ABC component of the protease secretion system PrtD, a 60-kDa integral membrane protein sharing 37% identity with HlyB, the ABC component of the alpha-hemolysin secretion pathway, in the C-terminal domain. They export...; Region: ABCC_Protease_Secretion; cd03246 114615008724 Walker A/P-loop; other site 114615008725 ATP binding site [chemical binding]; other site 114615008726 Q-loop/lid; other site 114615008727 ABC transporter signature motif; other site 114615008728 Walker B; other site 114615008729 D-loop; other site 114615008730 H-loop/switch region; other site 114615008731 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cl00159 114615008732 cyclase homology domain; Region: CHD; cd07302 114615008733 nucleotidyl binding site; other site 114615008734 dimer interface [polypeptide binding]; other site 114615008735 metal binding site [ion binding]; metal-binding site 114615008736 type I secretion membrane fusion protein, HlyD family; Region: type_I_hlyD; TIGR01843 114615008737 acetylornithine deacetylase or succinyl-diaminopimelate desuccinylase; Region: DapE-ArgE; TIGR01910 114615008738 M20 Peptidases with similarity to acetylornithine deacetylases and succinyl-diaminopimelate desuccinylases; Region: M20_ArgE_DapE_like2; cd03895 114615008739 metal binding site [ion binding]; metal-binding site 114615008740 dimer interface [polypeptide binding]; other site 114615008741 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 114615008742 CoenzymeA binding site [chemical binding]; other site 114615008743 subunit interaction site [polypeptide binding]; other site 114615008744 PHB binding site; other site 114615008745 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 114615008746 Uncharacterized conserved protein (DUF2161); Region: DUF2161; cl02298 114615008747 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 114615008748 dihydropteridine reductase (DHPR), classical (c) SDRs; Region: DHPR_SDR_c_like; cd05334 114615008749 NAD binding site [chemical binding]; other site 114615008750 homodimer interface [polypeptide binding]; other site 114615008751 active site 114615008752 SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cd00229 114615008753 active site 114615008754 catalytic triad [active] 114615008755 oxyanion hole [active] 114615008756 Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr (; Region: PTPc; cl00053 114615008757 Protein of unknown function (DUF2735); Region: DUF2735; pfam10931 114615008758 glutamine synthetase; Region: PLN02284 114615008759 Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951 114615008760 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 114615008761 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 114615008762 ABCF_EF-3 Elongation factor 3 (EF-3) is a cytosolic protein required by fungal ribosomes for in vitro protein synthesis and for in vivo growth. EF-3 stimulates the binding of the EF-1: GTP: aa-tRNA ternary complex to the ribosomal A site by...; Region: ABCF_EF-3; cd03221 114615008763 ABCF_EF-3 Elongation factor 3 (EF-3) is a cytosolic protein required by fungal ribosomes for in vitro protein synthesis and for in vivo growth. EF-3 stimulates the binding of the EF-1: GTP: aa-tRNA ternary complex to the ribosomal A site by...; Region: ABCF_EF-3; cd03221 114615008764 ABC transporter; Region: ABC_tran_2; pfam12848 114615008765 ABCF_EF-3 Elongation factor 3 (EF-3) is a cytosolic protein required by fungal ribosomes for in vitro protein synthesis and for in vivo growth. EF-3 stimulates the binding of the EF-1: GTP: aa-tRNA ternary complex to the ribosomal A site by...; Region: ABCF_EF-3; cd03221 114615008766 Dienelactone hydrolase and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG0412 114615008767 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 114615008768 PAS fold; Region: PAS_4; pfam08448 114615008769 sensory histidine kinase AtoS; Provisional; Region: PRK11360 114615008770 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via trans-...; Region: HisKA; cd00082 114615008771 dimer interface [polypeptide binding]; other site 114615008772 phosphorylation site [posttranslational modification] 114615008773 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 114615008774 ATP binding site [chemical binding]; other site 114615008775 Mg2+ binding site [ion binding]; other site 114615008776 G-X-G motif; other site 114615008777 Response regulator receiver domain; Region: Response_reg; pfam00072 114615008778 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156 114615008779 active site 114615008780 phosphorylation site [posttranslational modification] 114615008781 intermolecular recognition site; other site 114615008782 dimerization interface [polypeptide binding]; other site 114615008783 Protein of unknown function (DUF1810); Region: DUF1810; cl02370 114615008784 Protein of unknown function (DUF2778); Region: DUF2778; pfam10908 114615008785 Alkanesulfonate monoxygenase is the monoxygenase of a two-component system that catalyzes the conversion of alkanesulfonates to the corresponding aldehyde and sulfite. Alkanesulfonate monoxygenase (SsuD) has an absolute requirement for reduced flavin...; Region: Alkanesulfonate_monoxygenase; cd01094 114615008786 active site 114615008787 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases [Energy production and conversion]; Region: COG2141 114615008788 dimer interface [polypeptide binding]; other site 114615008789 non-prolyl cis peptide bond; other site 114615008790 insertion regions; other site 114615008791 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411 114615008792 The Mj1267/LivG ABC transporter subfamily is involved in the transport of the hydrophobic amino acids leucine, isoleucine and valine. MJ1267 is a branched-chain amino acid transporter with 29% similarity to both the LivF and LivG components of the E...; Region: ABC_Mj1267_LivG_branched; cd03219 114615008793 Walker A/P-loop; other site 114615008794 ATP binding site [chemical binding]; other site 114615008795 Q-loop/lid; other site 114615008796 ABC transporter signature motif; other site 114615008797 Walker B; other site 114615008798 D-loop; other site 114615008799 H-loop/switch region; other site 114615008800 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 114615008801 TM-ABC transporter signature motif; other site 114615008802 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 114615008803 TM-ABC transporter signature motif; other site 114615008804 Type I periplasmic ligand-binding domain of uncharacterized ABC (ATPase Binding Cassette)-type active transport systems that are predicted to be involved in transport of amino acids, peptides, or inorganic ions; Region: PBP1_ABC_ligand_binding_like_1; cd06334 114615008805 putative ligand binding site [chemical binding]; other site 114615008806 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410 114615008807 LivF (TM1139) is part of the LIV-I bacterial ABC-type two-component transport system that imports neutral, branched-chain amino acids. The E. coli branched-chain amino acid transporter comprises a heterodimer of ABC transporters (LivF and LivG), a...; Region: ABC_TM1139_LivF_branched; cd03224 114615008808 Walker A/P-loop; other site 114615008809 ATP binding site [chemical binding]; other site 114615008810 Q-loop/lid; other site 114615008811 ABC transporter signature motif; other site 114615008812 Walker B; other site 114615008813 D-loop; other site 114615008814 H-loop/switch region; other site 114615008815 NADPH-dependent FMN reductase; Region: FMN_red; cl00438 114615008816 DNA-binding transcriptional activator GcvA; Provisional; Region: PRK11139 114615008817 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 114615008818 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 114615008819 dimerization interface [polypeptide binding]; other site 114615008820 4-aminobutyrate aminotransferase; Provisional; Region: PRK07495 114615008821 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase...; Region: OAT_like; cd00610 114615008822 inhibitor-cofactor binding pocket; inhibition site 114615008823 pyridoxal 5'-phosphate binding site [chemical binding]; other site 114615008824 catalytic residue [active] 114615008825 acetylornithine deacetylase or succinyl-diaminopimelate desuccinylase; Region: DapE-ArgE; TIGR01910 114615008826 M20 Peptidases with similarity to acetylornithine deacetylases and succinyl-diaminopimelate desuccinylases; Region: M20_ArgE_DapE_like2; cd03895 114615008827 metal binding site [ion binding]; metal-binding site 114615008828 dimer interface [polypeptide binding]; other site 114615008829 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 114615008830 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cl00076 114615008831 Predicted phosphatases [General function prediction only]; Region: Gph; COG0546 114615008832 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others...; Region: HAD_like; cd01427 114615008833 motif II; other site 114615008834 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459 114615008835 putative diguanylate cyclase; Provisional; Region: PRK09776 114615008836 Motif C-terminal to PAS motifs (likely to contribute to PAS structural domain); Region: PAC; smart00086 114615008837 hypothetical protein; Provisional; Region: PRK13559 114615008838 Histidine kinase; Region: HisKA_2; cl06527 114615008839 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 114615008840 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 114615008841 ligand binding site [chemical binding]; other site 114615008842 flexible hinge region; other site 114615008843 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 114615008844 Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices connected by an extended linker. The...; Region: HAMP; cl01054 114615008845 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 114615008846 Taxis toward Aspartate and Related amino acids and Homologs (TarH). The Tar chemoreceptor of Escherichia coli mediates attractant responses to aspartate, maltose, and phenol, repellent responses to Ni2+ and Co2+, and thermoresponses. These...; Region: TarH; cl00144 114615008847 Predicted outer membrane protein [Function unknown]; Region: COG3652 114615008848 Protein of unknown function DUF72; Region: DUF72; cl00777 114615008849 Membrane bound L-sorbosone dehydrogenase; Region: SNDH; pfam12303 114615008850 putative membrane-bound dehydrogenase domain; Region: Piru_Ver_Nterm; TIGR02604 114615008851 Glucose / Sorbosone dehydrogenase; Region: GSDH; pfam07995 114615008852 Predicted membrane protein (DUF2231); Region: DUF2231; cl01730 114615008853 Chlorite dismutase; Region: Chlor_dismutase; cl01280 114615008854 3-hydroxybutyryl-CoA dehydrogenase; Validated; Region: PRK05808 114615008855 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 114615008856 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 114615008857 Uncharacterized protein conserved in bacteria (DUF2066); Region: DUF2066; cl01278 114615008858 Uncharacterized protein with a bacterial SH3 domain homologue [Function unknown]; Region: COG4991 114615008859 Bacterial SH3 domain; Region: SH3_3; cl02551 114615008860 Protein of unknown function (DUF3750); Region: DUF3750; pfam12570 114615008861 Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1)...; Region: Rieske; cd03467 114615008862 iron-sulfur cluster [ion binding]; other site 114615008863 [2Fe-2S] cluster binding site [ion binding]; other site 114615008864 Zinc ribbon domain; Region: CxxC_CxxC_SSSS; cl00993 114615008865 Predicted ring-cleavage extradiol dioxygenase [General function prediction only]; Region: COG2514 114615008866 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_12; cd07255 114615008867 putative metal binding site [ion binding]; other site 114615008868 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 114615008869 active site 114615008870 metal binding site [ion binding]; metal-binding site 114615008871 Uncharacterized Zn-ribbon-containing protein involved in phosphonate metabolism [Inorganic ion transport and metabolism]; Region: PhnA; COG2824 114615008872 PhnA Zinc-Ribbon; Region: PhnA_Zn_Ribbon; pfam08274 114615008873 PhnA protein; Region: PhnA; pfam03831 114615008874 Uncharacterized protein conserved in bacteria (DUF2312); Region: DUF2312; cl11480 114615008875 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 114615008876 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 114615008877 active site 114615008878 lysozyme_like domain. This contains several members including Soluble Lytic Transglycosylases (SLT), Goose Egg-White Lysozymes (GEWL), Hen Egg-White Lysozymes (HEWL), chitinases, bacteriophage lambda lysozymes, endolysins, autolysins, and chitosanases...; Region: lysozyme_like; cl00222 114615008879 Taxis toward Aspartate and Related amino acids and Homologs (TarH). The Tar chemoreceptor of Escherichia coli mediates attractant responses to aspartate, maltose, and phenol, repellent responses to Ni2+ and Co2+, and thermoresponses. These...; Region: TarH; cl00144 114615008880 Uncharacterized protein conserved in bacteria (DUF2171); Region: DUF2171; cl01558 114615008881 Uncharacterized conserved protein [Function unknown]; Region: COG5276 114615008882 Cytochrome P450; Region: p450; cl12078 114615008883 Protein tyrosine phosphatase, catalytic domain; Region: PTPc; smart00194 114615008884 Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr (; Region: PTPc; cl00053 114615008885 ribonucleotide-diphosphate reductase subunit alpha; Validated; Region: PRK07562 114615008886 Class II vitamin B12-dependent ribonucleotide reductase; Region: Ribonuc_red_2_N; pfam08471 114615008887 Ribonucleotide reductase and Pyruvate formate lyase; Region: RNR_PFL; cl09939 114615008888 Class II ribonucleotide reductase, dimeric form; Region: RNR_II_dimer; cd02888 114615008889 active site 114615008890 Ribonucleotide reductase and Pyruvate formate lyase; Region: RNR_PFL; cl09939 114615008891 TSCPD domain; Region: TSCPD; cl14834 114615008892 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 114615008893 EamA-like transporter family; Region: EamA; cl01037 114615008894 EamA-like transporter family; Region: EamA; cl01037 114615008895 CHASE3 domain; Region: CHASE3; cl05000 114615008896 sensory histidine kinase AtoS; Provisional; Region: PRK11360 114615008897 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459 114615008898 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via trans-...; Region: HisKA; cd00082 114615008899 dimer interface [polypeptide binding]; other site 114615008900 phosphorylation site [posttranslational modification] 114615008901 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 114615008902 ATP binding site [chemical binding]; other site 114615008903 G-X-G motif; other site 114615008904 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 114615008905 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156 114615008906 active site 114615008907 phosphorylation site [posttranslational modification] 114615008908 intermolecular recognition site; other site 114615008909 dimerization interface [polypeptide binding]; other site 114615008910 CHASE3 domain; Region: CHASE3; cl05000 114615008911 Signal transduction histidine kinase, nitrogen specific [Signal transduction mechanisms]; Region: NtrB; COG3852 114615008912 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459 114615008913 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via trans-...; Region: HisKA; cd00082 114615008914 dimer interface [polypeptide binding]; other site 114615008915 phosphorylation site [posttranslational modification] 114615008916 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 114615008917 ATP binding site [chemical binding]; other site 114615008918 Mg2+ binding site [ion binding]; other site 114615008919 G-X-G motif; other site 114615008920 Response regulator receiver domain; Region: Response_reg; pfam00072 114615008921 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156 114615008922 active site 114615008923 phosphorylation site [posttranslational modification] 114615008924 intermolecular recognition site; other site 114615008925 dimerization interface [polypeptide binding]; other site 114615008926 BA14K-like protein; Region: BA14K; pfam07886 114615008927 NADH ubiquinone oxidoreductase subunit NDUFA12; Region: NDUFA12; cl01534 114615008928 Type 1 glutamine amidotransferase (GATase1)-like domain found in a subgroup of proteins similar to PfpI from Pyrococcus furiosus; Region: GATase1_PfpI_2; cd03139 114615008929 conserved cys residue [active] 114615008930 Transcriptional regulator containing an amidase domain and an AraC-type DNA-binding HTH domain [Transcription]; Region: COG4977 114615008931 AraC transcriptional regulators having a Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GATase1_AraC_1; cd03137 114615008932 conserved cys residue [active] 114615008933 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 114615008934 A functionally uncharacterized subgroup of the Succinylglutamate desuccinylase (ASTE)/aspartoacylase (ASPA) subfamily which is part of the M14 family of metallocarboxypeptidases. ASTE catalyzes the fifth and last step in arginine catabolism by the...; Region: M14_ASTE_ASPA_like_6; cd06256 114615008935 putative active site [active] 114615008936 Zn-binding site [ion binding]; other site 114615008937 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; cl03087 114615008938 3-oxoacyl-(acyl-carrier-protein) reductase; Region: 3oxo_ACP_reduc; TIGR01830 114615008939 classical (c) SDRs; Region: SDR_c; cd05233 114615008940 NAD(P) binding site [chemical binding]; other site 114615008941 active site 114615008942 Malate:quinone oxidoreductase (Mqo); Region: Mqo; cl14881 114615008943 glycine oxidase ThiO; Region: thiamin_ThiO; TIGR02352 114615008944 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261 114615008945 dimer interface [polypeptide binding]; other site 114615008946 conserved gate region; other site 114615008947 putative PBP binding loops; other site 114615008948 ABC-ATPase subunit interface; other site 114615008949 Bacterial periplasmic substrate-binding proteins; Region: PBPb; smart00062 114615008950 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and...; Region: PBPb; cd00134 114615008951 substrate binding pocket [chemical binding]; other site 114615008952 membrane-bound complex binding site; other site 114615008953 hinge residues; other site 114615008954 Ketopantoate reductase [Coenzyme metabolism]; Region: ApbA; COG1893 114615008955 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 114615008956 Uncharacterized conserved protein [Function unknown]; Region: COG1284 114615008957 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 114615008958 pyridoxal 5'-phosphate binding site [chemical binding]; other site 114615008959 homodimer interface [polypeptide binding]; other site 114615008960 catalytic residue [active] 114615008961 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 114615008962 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 114615008963 substrate binding pocket [chemical binding]; other site 114615008964 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 114615008965 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK05565 114615008966 classical (c) SDRs; Region: SDR_c; cd05233 114615008967 NAD(P) binding site [chemical binding]; other site 114615008968 active site 114615008969 Uncharacterized protein conserved in bacteria (DUF2155); Region: DUF2155; cl01970 114615008970 Leucyl/phenylalanyl-tRNA protein transferase; Region: Leu_Phe_trans; cl01006 114615008971 Response regulator receiver domain; Region: Response_reg; pfam00072 114615008972 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156 114615008973 active site 114615008974 phosphorylation site [posttranslational modification] 114615008975 intermolecular recognition site; other site 114615008976 dimerization interface [polypeptide binding]; other site 114615008977 Histidine kinase; Region: HisKA_2; cl06527 114615008978 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 114615008979 ATP binding site [chemical binding]; other site 114615008980 Mg2+ binding site [ion binding]; other site 114615008981 G-X-G motif; other site 114615008982 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 114615008983 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156 114615008984 active site 114615008985 phosphorylation site [posttranslational modification] 114615008986 intermolecular recognition site; other site 114615008987 dimerization interface [polypeptide binding]; other site 114615008988 CHASE3 domain; Region: CHASE3; cl05000 114615008989 Bacteriophytochrome (light-regulated signal transduction histidine kinase) [Signal transduction mechanisms]; Region: COG4251 114615008990 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 114615008991 ATP binding site [chemical binding]; other site 114615008992 Mg2+ binding site [ion binding]; other site 114615008993 G-X-G motif; other site 114615008994 acetyl-CoA carboxylase biotin carboxylase subunit; Validated; Region: PRK08591 114615008995 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 114615008996 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; cl03087 114615008997 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; cl08365 114615008998 acetyl-CoA carboxylase biotin carboxyl carrier protein subunit; Validated; Region: PRK06302 114615008999 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase...; Region: biotinyl_domain; cd06850 114615009000 carboxyltransferase (CT) interaction site; other site 114615009001 biotinylation site [posttranslational modification]; other site 114615009002 Dehydroquinase (DHQase), type II. Dehydroquinase (or 3-dehydroquinate dehydratase) catalyzes the reversible dehydration of 3-dehydroquinate to form 3-dehydroshikimate. This reaction is part of two metabolic pathways: the biosynthetic shikimate pathway...; Region: DHQase_II; cl00505 114615009003 Protein of unknown function (DUF1236); Region: DUF1236; pfam06823 114615009004 tricarballylate utilization protein B; Provisional; Region: PRK15033 114615009005 tricarballylate dehydrogenase; Validated; Region: PRK08274 114615009006 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 114615009007 Transcriptional regulators [Transcription]; Region: FadR; COG2186 114615009008 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 114615009009 DNA-binding site [nucleotide binding]; DNA binding site 114615009010 FCD domain; Region: FCD; cl11656 114615009011 DsbA family, Com1-like subfamily; composed of proteins similar to Com1, a 27-kDa outer membrane-associated immunoreactive protein originally found in both acute and chronic disease strains of the pathogenic bacteria Coxiella burnetti. It contains a...; Region: DsbA_Com1_like; cd03023 114615009012 catalytic residues [active] 114615009013 Peptidase family M48; Region: Peptidase_M48; cl12018 114615009014 cellulose synthase subunit BcsC; Provisional; Region: PRK11447 114615009015 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi...; Region: TPR; cd00189 114615009016 TPR motif; other site 114615009017 binding surface 114615009018 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 114615009019 pyridoxal 5'-phosphate binding site [chemical binding]; other site 114615009020 homodimer interface [polypeptide binding]; other site 114615009021 catalytic residue [active] 114615009022 Sodium:dicarboxylate symporter family; Region: SDF; cl00573 114615009023 S1_RNase_E: RNase E and RNase G, S1-like RNA-binding domain. RNase E is an essential endoribonuclease in the processing and degradation of RNA. In addition to its role in mRNA degradation, RNase E has also been implicated in the processing of rRNA, and...; Region: S1_RNase_E; cd04453 114615009024 ribonuclease, Rne/Rng family; Region: RNaseEG; TIGR00757 114615009025 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain...; Region: S1_like; cl09927 114615009026 Localisation of periplasmic protein complexes; Region: AMIN; pfam11741 114615009027 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 114615009028 active site 114615009029 metal binding site [ion binding]; metal-binding site 114615009030 Membrane carboxypeptidase/penicillin-binding protein [Cell envelope biogenesis, outer membrane]; Region: MrcA; COG5009 114615009031 Transglycosylase; Region: Transgly; cl07896 114615009032 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01039 114615009033 peptide chain release factor 2; Provisional; Region: PRK07342 114615009034 RF-1 domain; Region: RF-1; cl02875 114615009035 RF-1 domain; Region: RF-1; cl02875 114615009036 NAD binding domain of 6-phosphogluconate dehydrogenase; Region: NAD_binding_2; pfam03446 114615009037 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 114615009038 Phosphoribosyl transferase domain; Region: Pribosyltran; cl00309 114615009039 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; cl10482 114615009040 Sodium/hydrogen exchanger family; Region: Na_H_Exchanger; pfam00999 114615009041 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 114615009042 Protein of unknown function (DUF3124); Region: DUF3124; pfam11322 114615009043 Lysin domain, found in a variety of enzymes involved in bacterial cell wall degradation. This domain may have a general peptidoglycan binding function; Region: LysM; cl00107 114615009044 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 114615009045 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 114615009046 DNA-binding site [nucleotide binding]; DNA binding site 114615009047 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 114615009048 pyridoxal 5'-phosphate binding site [chemical binding]; other site 114615009049 homodimer interface [polypeptide binding]; other site 114615009050 catalytic residue [active] 114615009051 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 114615009052 pyridoxal 5'-phosphate binding site [chemical binding]; other site 114615009053 homodimer interface [polypeptide binding]; other site 114615009054 catalytic residue [active] 114615009055 cystathionine beta-lyase; Provisional; Region: PRK07050 114615009056 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 114615009057 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 114615009058 catalytic residue [active] 114615009059 Lysin domain, found in a variety of enzymes involved in bacterial cell wall degradation. This domain may have a general peptidoglycan binding function; Region: LysM; cd00118 114615009060 putative peptidoglycan binding site; other site 114615009061 Phosphopantetheine attachment site; Region: PP-binding; cl09936 114615009062 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 114615009063 Peptidase family M23; Region: Peptidase_M23; pfam01551 114615009064 Peroxiredoxin (PRX) family, Bacterioferritin comigratory protein (BCP) subfamily; composed of thioredoxin-dependent thiol peroxidases, widely expressed in pathogenic bacteria, that protect cells against toxicity from reactive oxygen species by...; Region: PRX_BCP; cd03017 114615009065 catalytic triad [active] 114615009066 Major Facilitator Superfamily; Region: MFS_1; pfam07690 114615009067 tyrosyl-tRNA synthetase; Validated; Region: PRK05912 114615009068 catalytic core domain of tyrosinyl-tRNA synthetase; Region: TyrRS_core; cd00805 114615009069 active site 114615009070 HIGH motif; other site 114615009071 dimer interface [polypeptide binding]; other site 114615009072 KMSKS motif; other site 114615009073 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 114615009074 RNA binding surface [nucleotide binding]; other site 114615009075 Uncharacterised protein family (UPF0075); Region: UPF0075; cl04217 114615009076 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 114615009077 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 114615009078 C-terminal, alpha helical domain of the Glutathione S-transferase family; Region: GST_C_family; cd00299 114615009079 N-terminal domain interface [polypeptide binding]; other site 114615009080 dimer interface [polypeptide binding]; other site 114615009081 substrate binding pocket (H-site) [chemical binding]; other site 114615009082 Predicted hydrolase of the alpha/beta superfamily [General function prediction only]; Region: COG2945 114615009083 LytTr DNA-binding domain; Region: LytTR; cl04498 114615009084 Predicted O-acyltransferase [General function prediction only]; Region: COG3274; cl00792 114615009085 Acyltransferase family; Region: Acyl_transf_3; pfam01757 114615009086 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 114615009087 cysteine desulfurase DndA; Region: DNA_S_dndA; TIGR03235 114615009088 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 114615009089 catalytic residue [active] 114615009090 cysteine desulfurase activator complex subunit SufB; Provisional; Region: PRK11814; cl03223 114615009091 putative ABC transporter; Region: ycf24; CHL00085 114615009092 FeS assembly ATPase SufC; Region: sufC; TIGR01978 114615009093 ABC-type transport system involved in Fe-S cluster assembly, ATPase component. Biosynthesis of iron-sulfur clusters (Fe-S) depends on multiprotein systems. The SUF system of E. coli and Erwinia chrysanthemi is important for Fe-S biogenesis under...; Region: ABC_FeS_Assembly; cd03217 114615009094 Walker A/P-loop; other site 114615009095 ATP binding site [chemical binding]; other site 114615009096 Q-loop/lid; other site 114615009097 ABC transporter signature motif; other site 114615009098 Walker B; other site 114615009099 D-loop; other site 114615009100 H-loop/switch region; other site 114615009101 Cysteine desulfurase activator SufB [Posttranslational modification, protein turnover, chaperones]; Region: SufB; COG0719 114615009102 cysteine desulfurase activator complex subunit SufB; Provisional; Region: PRK11814; cl03223 114615009103 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 114615009104 Cysteine desulfurase (SufS)-like. This family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to cysteine desulfurase (SufS) and selenocysteine lyase. SufS...; Region: SufS_like; cd06453 114615009105 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 114615009106 catalytic residue [active] 114615009107 Domain of unknown function DUF59; Region: DUF59; cl00941 114615009108 Iron-sulphur cluster biosynthesis; Region: Fe-S_biosyn; cl00400 114615009109 TfoX N-terminal domain; Region: TfoX_N; cl01167 114615009110 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 114615009111 metal binding site [ion binding]; metal-binding site 114615009112 active site 114615009113 I-site; other site 114615009114 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (...; Region: DEADc; cd00268 114615009115 DEAD-like helicases superfamily; Region: DEXDc; smart00487 114615009116 ATP binding site [chemical binding]; other site 114615009117 Mg++ binding site [ion binding]; other site 114615009118 motif III; other site 114615009119 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 114615009120 nucleotide binding region [chemical binding]; other site 114615009121 ATP-binding site [chemical binding]; other site 114615009122 Protein of unknown function (DUF1211); Region: DUF1211; cl01421 114615009123 Caspase, interleukin-1 beta converting enzyme (ICE) homologues; Cysteine-dependent aspartate-directed proteases that mediate programmed cell death (apoptosis). Caspases are synthesized as inactive zymogens and activated by proteolysis of the peptide...; Region: CASc; cl00042 114615009124 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 114615009125 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 114615009126 NAD(P) binding site [chemical binding]; other site 114615009127 active site 114615009128 DNA topoisomerase IV subunit B; Reviewed; Region: PRK05559 114615009129 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 114615009130 ATP binding site [chemical binding]; other site 114615009131 Mg2+ binding site [ion binding]; other site 114615009132 G-X-G motif; other site 114615009133 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are...; Region: TopoII_Trans_DNA_gyrase; cd00822 114615009134 anchoring element; other site 114615009135 dimer interface [polypeptide binding]; other site 114615009136 ATP binding site [chemical binding]; other site 114615009137 Topoisomerase-primase domain. This is a nucleotidyl transferase/hydrolase domain found in type IA, type IIA and type IIB topoisomerases, bacterial DnaG-type primases, small primase-like proteins from bacteria and archaea, OLD family nucleases from...; Region: TOPRIM; cl00718 114615009138 active site 114615009139 metal binding site [ion binding]; metal-binding site 114615009140 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 114615009141 SNARE associated Golgi protein; Region: SNARE_assoc; cl00429 114615009142 Pyridoxine 5'-phosphate (PNP) oxidase-like proteins; Region: PNPOx_like; cl00381 114615009143 N-acetyl-gamma-glutamyl-phosphate reductase; Provisional; Region: PRK11863 114615009144 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 114615009145 threonine dehydratase; Provisional; Region: PRK07334 114615009146 Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562 114615009147 tetramer interface [polypeptide binding]; other site 114615009148 pyridoxal 5'-phosphate binding site [chemical binding]; other site 114615009149 catalytic residue [active] 114615009150 C-terminal ACT domain of biodegradative (catabolic) threonine dehydratase II (ThrD-II) and other related ACT domains; Region: ACT_ThrD-II-like; cd04886 114615009151 RNA ligase; Region: RNA_lig_T4_1; cl09743 114615009152 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 114615009153 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 114615009154 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261 114615009155 dimer interface [polypeptide binding]; other site 114615009156 conserved gate region; other site 114615009157 putative PBP binding loops; other site 114615009158 ABC-ATPase subunit interface; other site 114615009159 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 114615009160 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261 114615009161 dimer interface [polypeptide binding]; other site 114615009162 conserved gate region; other site 114615009163 putative PBP binding loops; other site 114615009164 ABC-ATPase subunit interface; other site 114615009165 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 114615009166 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 114615009167 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; cl11611 114615009168 Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GAT_1; cl00020 114615009169 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 114615009170 DNA binding site [nucleotide binding] 114615009171 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: RbsB; COG1879 114615009172 domain linker motif; other site 114615009173 Periplasmic sugar-binding domain of uncharacterized transport systems; Region: PBP1_uncharacterized_sugar_binding; cd06307 114615009174 putative ligand binding site [chemical binding]; other site 114615009175 MAPEG family; Region: MAPEG; cl09190 114615009176 poly(R)-hydroxyalkanoic acid synthase, class I; Region: PHA_synth_I; TIGR01838 114615009177 Poly-beta-hydroxybutyrate polymerase (PhaC) N-terminus; Region: PhaC_N; pfam07167 114615009178 aspartate aminotransferase; Provisional; Region: PRK07681 114615009179 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 114615009180 pyridoxal 5'-phosphate binding site [chemical binding]; other site 114615009181 homodimer interface [polypeptide binding]; other site 114615009182 catalytic residue [active] 114615009183 homoserine dehydrogenase; Provisional; Region: PRK06349 114615009184 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 114615009185 Homoserine dehydrogenase; Region: Homoserine_dh; pfam00742 114615009186 ACT_HSDH_Hom CD includes the C-terminal ACT domain of the NAD(P)H-dependent, homoserine dehydrogenase (HSDH) and related domains; Region: ACT_HSDH-Hom; cd04881 114615009187 Fructose-1,6-bisphosphatase/sedoheptulose 1,7-bisphosphatase and related proteins [Carbohydrate transport and metabolism]; Region: GlpX; COG1494 114615009188 Bacterial fructose-1,6-bisphosphatase, glpX-encoded. A dimeric enzyme dependent on Mg(2+). glpX-encoded FPBase (FBPase class II) differs from other members of the inositol-phosphatase superfamily by permutation of secondary structure elements. The core...; Region: FBPase_glpX; cd01516 114615009189 putative active site [active] 114615009190 Predicted hydrolase (HAD superfamily) [General function prediction only]; Region: COG1011 114615009191 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others...; Region: HAD_like; cl11391 114615009192 Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840 114615009193 single-stranded-DNA-specific exonuclease RecJ; Region: recJ; TIGR00644 114615009194 DHH family; Region: DHH; pfam01368 114615009195 DHHA1 domain; Region: DHHA1; pfam02272 114615009196 LabA_like proteins. A well conserved group of bacterial proteins with no defined function. LabA, a member from Synechococcus elongatus PCC 7942, has been shown to play a role in cyanobacterial circadian timing. It is required for negative feedback...; Region: LabA_like; cd06167 114615009197 putative metal binding site [ion binding]; other site 114615009198 LOTUS is an uncharacterized small globular domain found in Limkain b1, Oskar and Tudor-containing proteins 5 and 7; Region: LOTUS; cl14879 114615009199 lysozyme_like domain. This contains several members including Soluble Lytic Transglycosylases (SLT), Goose Egg-White Lysozymes (GEWL), Hen Egg-White Lysozymes (HEWL), chitinases, bacteriophage lambda lysozymes, endolysins, autolysins, and chitosanases...; Region: lysozyme_like; cl00222 114615009200 lytic murein transglycosylase; Region: MltB_2; TIGR02283 114615009201 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 114615009202 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 114615009203 Carboxymuconolactone decarboxylase family; Region: CMD; cl00460 114615009204 Peptidase family M23; Region: Peptidase_M23; pfam01551 114615009205 elongation factor P; Validated; Region: PRK00529 114615009206 Elongation factor P (EF-P) KOW-like domain; Region: EFP_N; pfam08207 114615009207 S1_EF-P_repeat_1: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with N-formylmethionyl-...; Region: S1_EF-P_repeat_1; cd04470 114615009208 RNA binding site [nucleotide binding]; other site 114615009209 S1_EF-P_repeat_2: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with N-formylmethionyl-...; Region: S1_EF-P_repeat_2; cd05794 114615009210 RNA binding site [nucleotide binding]; other site 114615009211 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 114615009212 lysyl-tRNA synthetase-like protein GenX; Region: genX; TIGR00462 114615009213 motif 1; other site 114615009214 dimer interface [polypeptide binding]; other site 114615009215 active site 114615009216 motif 2; other site 114615009217 motif 3; other site 114615009218 Lysine 2,3-aminomutase [Amino acid transport and metabolism]; Region: KamA; COG1509 114615009219 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster...; Region: Radical_SAM; cd01335 114615009220 FeS/SAM binding site; other site 114615009221 Lysine-2,3-aminomutase; Region: LAM_C; pfam12544 114615009222 NeuB family; Region: NeuB; cl00496 114615009223 DAHP synthetase I family; Region: DAHP_synth_1; pfam00793 114615009224 Uncharacterized conserved protein [Function unknown]; Region: HdeD; cl01277 114615009225 Membrane proteinase, regulator of anti-sigma factor [Posttranslational modification, protein turnover, chaperones]; Region: prsW; COG2339 114615009226 7-keto-8-aminopelargonate synthetase and related enzymes [Coenzyme metabolism]; Region: BioF; COG0156 114615009227 KBL_like; this family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to serine palmitoyltransferase (SPT), 5-aminolevulinate synthase (ALAS), 8-amino-7-...; Region: KBL_like; cd06454 114615009228 substrate-cofactor binding pocket; other site 114615009229 pyridoxal 5'-phosphate binding site [chemical binding]; other site 114615009230 catalytic residue [active] 114615009231 Uncharacterized conserved protein [Function unknown]; Region: COG3945 114615009232 Toluene-4-monooxygenase effector protein complex (T4mo), Rieske ferredoxin subunit; The Rieske domain is a [2Fe-2S] cluster binding domain involved in electron transfer. T4mo is a four-protein complex that catalyzes the NADH- and O2-dependent...; Region: Rieske_T4moC; cd03474 114615009233 [2Fe-2S] cluster binding site [ion binding]; other site 114615009234 Phage integrase family; Region: Phage_integrase; pfam00589 114615009235 C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family include the bacteriophage lambda integrase, the...; Region: INT_REC_C; cd01182 114615009236 DNA binding site [nucleotide binding] 114615009237 Int/Topo IB signature motif; other site 114615009238 active site 114615009239 catalytic residues [active] 114615009240 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (...; Region: S24_LexA-like; cd06529 114615009241 Catalytic site [active] 114615009242 Uncharacterized protein conserved in bacteria (DUF2312); Region: DUF2312; cl11480 114615009243 ParB-like nuclease domain; Region: ParBc; cl02129 114615009244 MT-A70; Region: MT-A70; cl01947 114615009245 N-Utilization Substance G (NusG) N-terminal (NGN) domain Superfamily; Region: NGN; cl02766 114615009246 Transcription antiterminator [Transcription]; Region: NusG; COG0250 114615009247 KOW motif; Region: KOW; cl00354 114615009248 FRG domain; Region: FRG; cl07460 114615009249 Phage terminase-like protein, large subunit [General function prediction only]; Region: COG4626 114615009250 Phage Terminase; Region: Terminase_1; pfam03354 114615009251 Phage Terminase; Region: Terminase_1; pfam03354 114615009252 Phage portal protein; Region: Phage_portal; pfam04860 114615009253 Phage-related protein [Function unknown]; Region: COG4695; cl01923 114615009254 Signal peptide peptidase A (SppA) 36K type, a serine protease, has catalytic Ser-Lys dyad; Region: S49_Sppa_36K_type; cd07022 114615009255 tandem repeat interface [polypeptide binding]; other site 114615009256 oligomer interface [polypeptide binding]; other site 114615009257 active site residues [active] 114615009258 phage major capsid protein, HK97 family; Region: major_cap_HK97; TIGR01554 114615009259 Phage capsid family; Region: Phage_capsid; pfam05065 114615009260 Head-Tail Connector Proteins gp6 and gp15, and similar proteins; Region: gp6_gp15_like; cl12049 114615009261 Domain of unknown function (DUF1833); Region: DUF1833; pfam08875 114615009262 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 114615009263 Phage-related protein, tail component [Function unknown]; Region: COG4733 114615009264 NlpC/P60 family; Region: NLPC_P60; cl11438 114615009265 PilZ domain; Region: PilZ; cl01260 114615009266 Porin subfamily; Region: Porin_2; pfam02530 114615009267 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 114615009268 GST_N family, unknown subfamily 2; composed of uncharacterized bacterial proteins with similarity to GSTs. GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of...; Region: GST_N_2; cd03047 114615009269 putative C-terminal domain interface [polypeptide binding]; other site 114615009270 putative GSH binding site (G-site) [chemical binding]; other site 114615009271 putative dimer interface [polypeptide binding]; other site 114615009272 C-terminal, alpha helical domain of an unknown subfamily 2 of Glutathione S-transferases; Region: GST_C_2; cd03180 114615009273 putative N-terminal domain interface [polypeptide binding]; other site 114615009274 putative dimer interface [polypeptide binding]; other site 114615009275 putative substrate binding pocket (H-site) [chemical binding]; other site 114615009276 Glyoxalase I catalyzes the isomerization of the hemithioacetal, formed by a 2-oxoaldehyde and glutathione, to S-D-lactoylglutathione; Region: Glyoxalase_I; cd07233 114615009277 dimer interface [polypeptide binding]; other site 114615009278 active site 114615009279 metal binding site [ion binding]; metal-binding site 114615009280 glutathione binding site [chemical binding]; other site 114615009281 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and higher-...; Region: HU_IHF; cd00591 114615009282 IHF dimer interface [polypeptide binding]; other site 114615009283 IHF - DNA interface [nucleotide binding]; other site 114615009284 NAD-dependent deacetylase; Provisional; Region: PRK14138 114615009285 SIR2 superfamily of proteins includes silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein/histone deacetylation, where the acetyl group from the lysine epsilon-amino group is transferred to the ADP-ribose moiety of NAD+...; Region: SIR2; cl00195 114615009286 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box protein...; Region: CSP_CDS; cd04458 114615009287 DNA-binding site [nucleotide binding]; DNA binding site 114615009288 RNA-binding motif; other site 114615009289 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box protein...; Region: CSP_CDS; cd04458 114615009290 DNA-binding site [nucleotide binding]; DNA binding site 114615009291 RNA-binding motif; other site 114615009292 OpgC protein; Region: OpgC_C; cl10497 114615009293 ETC complex I subunit conserved region; Region: ETC_C1_NDUFA4; pfam04800 114615009294 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 114615009295 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 114615009296 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 114615009297 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 114615009298 3-methylcrotonyl-CoA carboxylase, beta chain; Region: PLN02820 114615009299 Acetyl co-enzyme A carboxylase carboxyltransferase alpha subunit; Region: ACCA; cl00513 114615009300 Acetyl co-enzyme A carboxylase carboxyltransferase alpha subunit; Region: ACCA; cl00513 114615009301 Acetyl/propionyl-CoA carboxylase, alpha subunit [Lipid metabolism]; Region: COG4770 114615009302 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 114615009303 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; cl03087 114615009304 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; cl08365 114615009305 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase...; Region: biotinyl_domain; cd06850 114615009306 carboxyltransferase (CT) interaction site; other site 114615009307 biotinylation site [posttranslational modification]; other site 114615009308 3-hydroxy-3-methylglutaryl-CoA lyase, catalytic TIM barrel domain; Region: DRE_TIM_HMGL; cd07938 114615009309 active site 114615009310 catalytic residues [active] 114615009311 metal binding site [ion binding]; metal-binding site 114615009312 DctM-like transporters; Region: DctM; pfam06808 114615009313 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl09110 114615009314 Tripartite ATP-independent periplasmic transporters, DctQ component; Region: DctQ; cl01181 114615009315 Bacterial extracellular solute-binding protein, family 7; Region: SBP_bac_7; cl00710 114615009316 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or...; Region: Nudix_Hydrolase; cd02883 114615009317 nudix motif; other site 114615009318 Truncated hemoglobins (trHbs) are a family of oxygen-binding heme proteins found in cyanobacteria, eubacteria, unicellular eukaryotes, and plants. The truncated hemoglobins have a characteristic two-over-two alpha helical folding pattern that is...; Region: Trunc_globin; cd00454 114615009319 apolar tunnel; other site 114615009320 heme binding site [chemical binding]; other site 114615009321 dimerization interface [polypeptide binding]; other site 114615009322 Response regulator receiver domain; Region: Response_reg; pfam00072 114615009323 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156 114615009324 active site 114615009325 phosphorylation site [posttranslational modification] 114615009326 intermolecular recognition site; other site 114615009327 dimerization interface [polypeptide binding]; other site 114615009328 Protein involved in meta-pathway of phenol degradation [Energy production and conversion]; Region: COG4313 114615009329 Transcriptional regulator [Transcription]; Region: LysR; COG0583 114615009330 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 114615009331 The C-terminal substsrate binding domain of NodD family of LysR-type transcriptional regulators that regulates the expression of nodulation (nod) genes; contains the type 2 periplasmic binding fold; Region: PBP2_NodD; cd08462 114615009332 putative substrate binding pocket [chemical binding]; other site 114615009333 putative dimerization interface [polypeptide binding]; other site 114615009334 Hydrolases of the alpha/beta superfamily [General function prediction only]; Region: COG1073 114615009335 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 114615009336 C-terminal domain of Burkholderia sp. NF100 MhqB and similar proteins; MhqB is a type I extradiol dioxygenase involved in the catabolism of methylhydroquinone, an intermediate in the degradation of fenitrothion; Region: MhqB_like_C; cd08360 114615009337 putative active site [active] 114615009338 putative metal binding site [ion binding]; other site 114615009339 Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1)...; Region: Rieske; cd03467 114615009340 iron-sulfur cluster [ion binding]; other site 114615009341 [2Fe-2S] cluster binding site [ion binding]; other site 114615009342 hypothetical protein; Provisional; Region: PRK06847 114615009343 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 114615009344 Cupin domain; Region: Cupin_2; cl09118 114615009345 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; cl11421 114615009346 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 114615009347 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 114615009348 NAD(P) binding site [chemical binding]; other site 114615009349 active site 114615009350 short chain dehydrogenase; Provisional; Region: PRK06181 114615009351 classical (c) SDRs; Region: SDR_c; cd05233 114615009352 NAD(P) binding site [chemical binding]; other site 114615009353 active site 114615009354 Peroxiredoxin (PRX)-like 2 family; hypothetical proteins that show sequence similarity to PRXs. Members of this group contain a CXXC motif, similar to TRX. The second cysteine in the motif corresponds to the peroxidatic cysteine of PRX, however, these...; Region: PRX_like2; cd02970 114615009355 putative catalytic residues [active] 114615009356 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase...; Region: crotonase-like; cd06558 114615009357 substrate binding site [chemical binding]; other site 114615009358 oxyanion hole (OAH) forming residues; other site 114615009359 trimer interface [polypeptide binding]; other site 114615009360 transcriptional regulator; Provisional; Region: PRK10632 114615009361 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 114615009362 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 114615009363 putative effector binding pocket; other site 114615009364 dimerization interface [polypeptide binding]; other site 114615009365 polynucleotide kinase-phosphatase; Region: bacter_Pnkp; TIGR04075 114615009366 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 114615009367 Bacillus subtilis PrpE and related proteins, metallophosphatase domain; Region: MPP_PrpE; cd07423 114615009368 active site 114615009369 metal binding site [ion binding]; metal-binding site 114615009370 RNA repair, ligase-Pnkp-associating, region of Hen1; Region: Hen1_L; pfam12623 114615009371 3' terminal RNA ribose 2'-O-methyltransferase Hen1; Region: bacter_Hen1; TIGR04074 114615009372 TROVE domain; Region: TROVE; pfam05731 114615009373 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057 114615009374 hypothetical protein; Provisional; Region: PRK07877 114615009375 GSH-dependent disulfide bond oxidoreductase; Provisional; Region: PRK13972 114615009376 GST_N family, Ure2p-like subfamily; composed of the Saccharomyces cerevisiae Ure2p and related GSTs. Ure2p is a regulator for nitrogen catabolism in yeast. It represses the expression of several gene products involved in the use of poor nitrogen...; Region: GST_N_Ure2p_like; cd03048 114615009377 C-terminal domain interface [polypeptide binding]; other site 114615009378 GSH binding site (G-site) [chemical binding]; other site 114615009379 dimer interface [polypeptide binding]; other site 114615009380 C-terminal, alpha helical domain of Ure2p and related Glutathione S-transferase-like proteins; Region: GST_C_Ure2p_like; cd03178 114615009381 dimer interface [polypeptide binding]; other site 114615009382 N-terminal domain interface [polypeptide binding]; other site 114615009383 Uncharacterized protein conserved in bacteria (DUF2236); Region: DUF2236; cl01472 114615009384 Arsenate Reductase (ArsC) family, Yffb subfamily; Yffb is an uncharacterized bacterial protein encoded by the yffb gene, related to the thioredoxin-fold arsenic reductases, ArsC. The structure of Yffb and the conservation of the catalytic cysteine...; Region: ArsC_Yffb; cd03035 114615009385 putative catalytic residues [active] 114615009386 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 114615009387 Peptidase family M48; Region: Peptidase_M48; cl12018 114615009388 Protein of unknown function (DUF1800); Region: DUF1800; pfam08811 114615009389 Protein of unknown function (DUF1501); Region: DUF1501; cl01699 114615009390 Dipeptidyl aminopeptidases/acylaminoacyl-peptidases [Amino acid transport and metabolism]; Region: DAP2; COG1506 114615009391 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 114615009392 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411 114615009393 The Mj1267/LivG ABC transporter subfamily is involved in the transport of the hydrophobic amino acids leucine, isoleucine and valine. MJ1267 is a branched-chain amino acid transporter with 29% similarity to both the LivF and LivG components of the E...; Region: ABC_Mj1267_LivG_branched; cd03219 114615009394 Walker A/P-loop; other site 114615009395 ATP binding site [chemical binding]; other site 114615009396 Q-loop/lid; other site 114615009397 ABC transporter signature motif; other site 114615009398 Walker B; other site 114615009399 D-loop; other site 114615009400 H-loop/switch region; other site 114615009401 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410 114615009402 LivF (TM1139) is part of the LIV-I bacterial ABC-type two-component transport system that imports neutral, branched-chain amino acids. The E. coli branched-chain amino acid transporter comprises a heterodimer of ABC transporters (LivF and LivG), a...; Region: ABC_TM1139_LivF_branched; cd03224 114615009403 Walker A/P-loop; other site 114615009404 ATP binding site [chemical binding]; other site 114615009405 Q-loop/lid; other site 114615009406 ABC transporter signature motif; other site 114615009407 Walker B; other site 114615009408 D-loop; other site 114615009409 H-loop/switch region; other site 114615009410 ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683 114615009411 Periplasmic solute-binding domain of active transport proteins that belong to the type I periplasmic binding fold protein family; Region: PBP1_SBP_like_1; cd06327 114615009412 putative ligand binding site [chemical binding]; other site 114615009413 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 114615009414 TM-ABC transporter signature motif; other site 114615009415 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 114615009416 TM-ABC transporter signature motif; other site 114615009417 Phosphate transport regulator (distant homolog of PhoU) [Inorganic ion transport and metabolism]; Region: COG1392 114615009418 Phosphate transporter family; Region: PHO4; cl00396 114615009419 peptide chain release factor 3; Provisional; Region: prfC; PRK00741 114615009420 RF3 subfamily. Peptide chain release factor 3 (RF3) is a protein involved in the termination step of translation in bacteria. Termination occurs when class I release factors (RF1 or RF2) recognize the stop codon at the A-site of the ribosome and...; Region: RF3; cd04169 114615009421 G1 box; other site 114615009422 putative GEF interaction site [polypeptide binding]; other site 114615009423 GTP/Mg2+ binding site [chemical binding]; other site 114615009424 Switch I region; other site 114615009425 G2 box; other site 114615009426 G3 box; other site 114615009427 Switch II region; other site 114615009428 G4 box; other site 114615009429 G5 box; other site 114615009430 RF3_II: this subfamily represents the domain II of bacterial Release Factor 3 (RF3). Termination of protein synthesis by the ribosome requires two release factor (RF) classes. The class II RF3 is a GTPase that removes class I RFs (RF1 or RF2) from the...; Region: RF3_II; cd03689 114615009431 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors...; Region: LuxR_C_like; cd06170 114615009432 DNA binding residues [nucleotide binding] 114615009433 dimerization interface [polypeptide binding]; other site 114615009434 Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]; Region: DegQ; COG0265 114615009435 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind C-...; Region: PDZ_serine_protease; cd00987 114615009436 protein binding site [polypeptide binding]; other site 114615009437 Asp/Glu/Hydantoin racemase; Region: Asp_Glu_race; cl00518 114615009438 NnrU protein; Region: NnrU; cl01697 114615009439 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK06187 114615009440 Acyl-protein synthetase, LuxE; Region: LuxE; cl10450 114615009441 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4649 114615009442 GTP-binding protein Der; Reviewed; Region: PRK00093 114615009443 EngA1 subfamily. This CD represents the first GTPase domain of EngA and its orthologs, which are composed of two adjacent GTPase domains. Since the sequences of the two domains are more similar to each other than to other GTPases, it is likely that...; Region: EngA1; cd01894 114615009444 G1 box; other site 114615009445 GTP/Mg2+ binding site [chemical binding]; other site 114615009446 Switch I region; other site 114615009447 G2 box; other site 114615009448 Switch II region; other site 114615009449 G3 box; other site 114615009450 G4 box; other site 114615009451 G5 box; other site 114615009452 EngA2 subfamily. This CD represents the second GTPase domain of EngA and its orthologs, which are composed of two adjacent GTPase domains. Since the sequences of the two domains are more similar to each other than to other GTPases, it is likely that...; Region: EngA2; cd01895 114615009453 G1 box; other site 114615009454 GTP/Mg2+ binding site [chemical binding]; other site 114615009455 Switch I region; other site 114615009456 G2 box; other site 114615009457 G3 box; other site 114615009458 Switch II region; other site 114615009459 G4 box; other site 114615009460 G5 box; other site 114615009461 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl15258 114615009462 Predicted transcriptional regulator [General function prediction only]; Region: COG3800 114615009463 Domain of unknown function (DUF955); Region: DUF955; cl01076 114615009464 Predicted transcriptional regulator (DUF2083); Region: DUF2083; pfam09856 114615009465 isocitrate lyase; Provisional; Region: PRK06498 114615009466 Members of the ICL/PEPM enzyme family catalyze either P-C or C-C bond formation/cleavage. Known members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate hydrolase (OAH), isocitrate...; Region: ICL_PEPM; cd00377 114615009467 tetramer interface [polypeptide binding]; other site 114615009468 active site 114615009469 Mg2+/Mn2+ binding site [ion binding]; other site 114615009470 Members of the ICL/PEPM_KPHMT enzyme superfamily catalyze the formation and cleavage of either P-C or C-C bonds. Typical members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate...; Region: ICL_KPHMT; cl00435 114615009471 LysE type translocator; Region: LysE; cl00565 114615009472 Glycosyl hydrolases family 17; Region: Glyco_hydro_17; cl02191 114615009473 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 114615009474 active site 114615009475 Glycosyl hydrolases family 17; Region: Glyco_hydro_17; cl02191 114615009476 bifunctional N-acetylglucosamine-1-phosphate uridyltransferase/glucosamine-1-phosphate acetyltransferase; Provisional; Region: glmU; PRK14353 114615009477 N-terminal domain of bacterial GlmU; Region: GT2_GlmU_N_bac; cd02540 114615009478 Substrate binding site [chemical binding]; other site 114615009479 Mg++ binding site [ion binding]; other site 114615009480 N-acetyl-glucosamine-1-phosphate uridyltransferase (GlmU), C-terminal left-handed beta-helix (LbH) acetyltransferase domain: GlmU is also known as UDP-N-acetylglucosamine pyrophosphorylase. It is a bifunctional bacterial enzyme that catalyzes two...; Region: LbH_GlmU_C; cd03353 114615009481 active site 114615009482 substrate binding site [chemical binding]; other site 114615009483 CoA binding site [chemical binding]; other site 114615009484 glucosamine--fructose-6-phosphate aminotransferase; Reviewed; Region: PRK00331 114615009485 Glutamine amidotransferases class-II (Gn-AT)_GFAT-type. This domain is found at the N-terminus of glucosamine-6P synthase (GlmS, or GFAT in humans). The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the appropriate substrate...; Region: GFAT; cd00714 114615009486 glutaminase active site [active] 114615009487 SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008 114615009488 dimer interface [polypeptide binding]; other site 114615009489 active site 114615009490 SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009 114615009491 dimer interface [polypeptide binding]; other site 114615009492 active site 114615009493 LysE type translocator; Region: LysE; cl00565 114615009494 Protein of unknown function (DUF502); Region: DUF502; cl01107 114615009495 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_11; cd07261 114615009496 putative dimer interface [polypeptide binding]; other site 114615009497 Phospholipase/lecithinase/hemolysin [Lipid metabolism / General function prediction only]; Region: COG3240 114615009498 Triacylglycerol lipase-like subfamily of the SGNH hydrolases, a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its...; Region: Triacylglycerol_lipase_like; cd01847 114615009499 active site 114615009500 catalytic triad [active] 114615009501 oxyanion hole [active] 114615009502 general secretion pathway protein G; Region: typeII_sec_gspG; TIGR01710 114615009503 Autotransporter beta-domain; Region: Autotransporter; cl02365 114615009504 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084 114615009505 Domain of unknown function (DUF1932); Region: DUF1932; pfam09130 114615009506 ATP-dependent DNA helicase RecG; Provisional; Region: PRK10917 114615009507 RecG_wedge_OBF: A subfamily of OB folds corresponding to the OB fold found in the N-terminal (wedge) domain of Escherichia coli RecG. RecG is a branched-DNA-specific helicase, which catalyzes the interconversion of a DNA replication fork to a four-...; Region: RecG_wedge_OBF; cd04488 114615009508 ssDNA binding site; other site 114615009509 generic binding surface II; other site 114615009510 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 114615009511 ATP binding site [chemical binding]; other site 114615009512 putative Mg++ binding site [ion binding]; other site 114615009513 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 114615009514 nucleotide binding region [chemical binding]; other site 114615009515 ATP-binding site [chemical binding]; other site 114615009516 Flavinator of succinate dehydrogenase; Region: Sdh5; cl01110 114615009517 Transcription-repair coupling factor (superfamily II helicase) [DNA replication, recombination, and repair / Transcription]; Region: Mfd; COG1197 114615009518 CarD-like/TRCF domain; Region: CarD_TRCF; cl00588 114615009519 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 114615009520 ATP binding site [chemical binding]; other site 114615009521 putative Mg++ binding site [ion binding]; other site 114615009522 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 114615009523 nucleotide binding region [chemical binding]; other site 114615009524 ATP-binding site [chemical binding]; other site 114615009525 TRCF domain; Region: TRCF; cl04088 114615009526 Predicted acetyltransferases and hydrolases with the alpha/beta hydrolase fold [General function prediction only]; Region: LipA; COG1075 114615009527 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 114615009528 phosphatidylcholine-sterol O-acyltransferase; Region: PLN02733 114615009529 Class III nucleotidyl cyclases; Region: Nucleotidyl_cyc_III; cl11967 114615009530 peptide synthase; Provisional; Region: PRK12467 114615009531 AMP-binding enzyme; Region: AMP-binding; pfam00501 114615009532 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 114615009533 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_14; cd08497 114615009534 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cl01709 114615009535 Invasion associated locus B (IalB) protein; Region: IalB; cl02207 114615009536 Hemimethylated DNA-binding protein YccV like; Region: YccV-like; cl01548 114615009537 Membrane transport protein; Region: Mem_trans; cl09117 114615009538 2-octaprenyl-6-methoxyphenyl hydroxylase; Provisional; Region: PRK07494 114615009539 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 114615009540 Phosphatidylserine synthase [Lipid metabolism]; Region: PssA; COG1183 114615009541 CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; cl00453 114615009542 Integral membrane protein TerC family; Region: TerC; cl10468 114615009543 quinone oxidoreductase, NADPH-dependent; Provisional; Region: PRK10754 114615009544 Quinone oxidoreductase (QOR); Region: QOR2; cd05286 114615009545 NADP binding site [chemical binding]; other site 114615009546 dimer interface [polypeptide binding]; other site 114615009547 Luciferase-like monooxygenase; Region: Bac_luciferase; pfam00296 114615009548 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 114615009549 acetylornithine transaminase protein; Provisional; Region: argD; PRK03715 114615009550 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase...; Region: OAT_like; cd00610 114615009551 inhibitor-cofactor binding pocket; inhibition site 114615009552 pyridoxal 5'-phosphate binding site [chemical binding]; other site 114615009553 catalytic residue [active] 114615009554 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5330 114615009555 Uncharacterized protein conserved in bacteria (DUF2336); Region: DUF2336; pfam10098 114615009556 ribosomal protein S12 methylthiotransferase; Provisional; Region: rimO; PRK14862 114615009557 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 114615009558 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster...; Region: Radical_SAM; cd01335 114615009559 FeS/SAM binding site; other site 114615009560 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cl09944 114615009561 Response regulator with putative antiterminator output domain [Signal transduction mechanisms]; Region: AmiR; COG3707 114615009562 ANTAR domain; Region: ANTAR; cl04297 114615009563 ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components [Inorganic ion transport and metabolism]; Region: TauA; COG0715 114615009564 ferredoxin-nitrite reductase; Reviewed; Region: nirA; PRK09567 114615009565 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 114615009566 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 114615009567 sulfite reductase; Provisional; Region: PRK06214 114615009568 Cytochrome p450- like alpha subunits of E. coli sulfite reductase (SiR) multimerize with beta subunits to catalyze the NADPH dependent reduction of sulfite to sulfide. Beta subunits have an Fe4S4 cluster and a siroheme, while the alpha subunits (cysJ...; Region: SiR; cd06199 114615009569 FAD binding pocket [chemical binding]; other site 114615009570 FAD binding motif [chemical binding]; other site 114615009571 catalytic residues [active] 114615009572 NAD binding pocket [chemical binding]; other site 114615009573 phosphate binding motif [ion binding]; other site 114615009574 beta-alpha-beta structure motif; other site 114615009575 LamB/YcsF family; Region: LamB_YcsF; cl00664 114615009576 Allophanate hydrolase subunit 2; Region: AHS2; cl00865 114615009577 Allophanate hydrolase subunit 2; Region: AHS2; pfam02626 114615009578 Allophanate hydrolase subunit 1; Region: AHS1; smart00796 114615009579 Allophanate hydrolase subunit 1 [Amino acid transport and metabolism]; Region: DUR1; cl00896 114615009580 Demethylmenaquinone methyltransferase; Region: Methyltransf_6; cl00480 114615009581 Cupin domain; Region: Cupin_2; cl09118 114615009582 Uncharacterized protein conserved in bacteria (DUF2147); Region: DUF2147; cl01951 114615009583 leucine-responsive transcriptional regulator; Provisional; Region: PRK11169 114615009584 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 114615009585 1-aminocyclopropane-1-carboxylate deaminase [Amino acid transport and metabolism]; Region: Acd; COG2515 114615009586 Aminocyclopropane-1-carboxylate deaminase (ACCD): Pyridoxal phosphate (PLP)-dependent enzyme which catalyzes the conversion of 1-aminocyclopropane-L-carboxylate (ACC), a precursor of the plant hormone ethylene, to alpha-ketobutyrate and ammonia; Region: ACCD; cd06449 114615009587 pyridoxal 5'-phosphate binding site [chemical binding]; other site 114615009588 catalytic residue [active] 114615009589 elongation factor G; Reviewed; Region: PRK00007 114615009590 Elongation factor G (EF-G) subfamily. Translocation is mediated by EF-G (also called translocase). The structure of EF-G closely resembles that of the complex between EF-Tu and tRNA. This is an example of molecular mimicry; a protein domain evolved...; Region: EF-G; cd01886 114615009591 G1 box; other site 114615009592 putative GEF interaction site [polypeptide binding]; other site 114615009593 GTP/Mg2+ binding site [chemical binding]; other site 114615009594 Switch I region; other site 114615009595 G2 box; other site 114615009596 G3 box; other site 114615009597 Switch II region; other site 114615009598 G4 box; other site 114615009599 G5 box; other site 114615009600 EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide...; Region: EFG_mtEFG_II; cd04088 114615009601 EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor...; Region: EFG_mtEFG1_IV; cd01434 114615009602 EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G. Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor...; Region: EFG_mtEFG_C; cd03713 114615009603 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 114615009604 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 114615009605 High-affinity nickel-transport protein; Region: NicO; cl00964 114615009606 High-affinity nickel-transport protein; Region: NicO; cl00964 114615009607 Transcriptional regulators RcnR and FrmR, and related domains; this domain family was previously known as part of DUF156; Region: RcnR-FrmR-like_DUF156; cd10153 114615009608 putative metal binding site [ion binding]; other site 114615009609 putative homotetramer interface [polypeptide binding]; other site 114615009610 putative homodimer interface [polypeptide binding]; other site 114615009611 putative homodimer-homodimer interface [polypeptide binding]; other site 114615009612 putative allosteric switch controlling residues; other site 114615009613 Bacterial periplasmic substrate-binding proteins; Region: PBPb; smart00062 114615009614 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and...; Region: PBPb; cd00134 114615009615 substrate binding pocket [chemical binding]; other site 114615009616 membrane-bound complex binding site; other site 114615009617 hinge residues; other site 114615009618 Domain of unknown function (DUF1993); Region: DUF1993; cl01567 114615009619 Phosphoglycerate dehydrogenase and related dehydrogenases [Amino acid transport and metabolism]; Region: SerA; COG0111 114615009620 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 114615009621 glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650 114615009622 The N-terminal ATPase domain of the maltose transporter, MalK. ATP binding cassette (ABC) proteins function from bacteria to human, mediating the translocation of substances into and out of cells or organelles. ABC transporters contain two...; Region: ABC_MalK_N; cd03301 114615009623 Walker A/P-loop; other site 114615009624 ATP binding site [chemical binding]; other site 114615009625 Q-loop/lid; other site 114615009626 ABC transporter signature motif; other site 114615009627 Walker B; other site 114615009628 D-loop; other site 114615009629 H-loop/switch region; other site 114615009630 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 114615009631 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261 114615009632 dimer interface [polypeptide binding]; other site 114615009633 conserved gate region; other site 114615009634 putative PBP binding loops; other site 114615009635 ABC-ATPase subunit interface; other site 114615009636 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261 114615009637 dimer interface [polypeptide binding]; other site 114615009638 conserved gate region; other site 114615009639 putative PBP binding loops; other site 114615009640 ABC-ATPase subunit interface; other site 114615009641 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 114615009642 Lipoproteins [Cell envelope biogenesis, outer membrane]; Region: RlpA; COG0797 114615009643 Rare lipoprotein A (RlpA)-like double-psi beta-barrel; Region: DPBB_1; cl04011 114615009644 Transcription factors (IPT). IPTs are also known as Transcription factor ImmunoGlobin (TIG) domains. They are present in intracellular transcription factors, cell surface receptors (such as plexins and scatter factor receptors), as well as...; Region: IPT; cd00102 114615009645 IPT domain of Plexins and Cell Surface Receptors (PCSR) and related proteins . This subgroup contains IPT domains of plexins, receptors, like the plasminogen-related growth factor receptors, the hepatocyte growth factor-scatter factors, and the...; Region: IPT_PCSR; cd00603 114615009646 Autotransporter beta-domain; Region: Autotransporter; cl02365 114615009647 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 114615009648 Chlorophyllase; Region: Chlorophyllase; cl15281 114615009649 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 114615009650 Beta-lactamase; Region: Beta-lactamase; cl01009 114615009651 D-alanyl-D-alanine carboxypeptidase; Region: Peptidase_S11; pfam00768 114615009652 Penicillin-binding protein 5, C-terminal domain; Region: PBP5_C; cl06814 114615009653 thymidylate kinase; Validated; Region: tmk; PRK00698 114615009654 Thymidine monophosphate kinase (TMPK), also known as thymidylate kinase, catalyzes the phosphorylation of thymidine monophosphate (TMP) to thymidine diphosphate (TDP) utilizing ATP as its preferred phophoryl donor. TMPK represents the rate-limiting...; Region: TMPK; cd01672 114615009655 TMP-binding site; other site 114615009656 ATP-binding site [chemical binding]; other site 114615009657 DNA polymerase III subunit delta'; Validated; Region: PRK07471 114615009658 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 114615009659 methionyl-tRNA synthetase; Reviewed; Region: PRK11893 114615009660 catalytic core domain of methioninyl-tRNA synthetases; Region: MetRS_core; cd00814 114615009661 active site 114615009662 HIGH motif; other site 114615009663 KMSKS motif; other site 114615009664 Anticodon-binding domain of methionyl tRNA synthetases; Region: Anticodon_Ia_Met; cd07957 114615009665 tRNA binding surface [nucleotide binding]; other site 114615009666 anticodon binding site; other site 114615009667 TatD like proteins; E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310 114615009668 putative deoxyribonuclease YjjV; Provisional; Region: PRK11449 114615009669 active site 114615009670 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 114615009671 Antibiotic biosynthesis monooxygenase; Region: ABM; cl10022 114615009672 acyl-CoA synthetase; Validated; Region: PRK08162 114615009673 Acyl-protein synthetase, LuxE; Region: LuxE; cl10450 114615009674 Tripartite ATP-independent periplasmic transporters, DctQ component; Region: DctQ; cl01181 114615009675 DctM-like transporters; Region: DctM; pfam06808 114615009676 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl09110 114615009677 Bacterial extracellular solute-binding protein, family 7; Region: SBP_bac_7; cl00710 114615009678 ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129 114615009679 The Mj1267/LivG ABC transporter subfamily is involved in the transport of the hydrophobic amino acids leucine, isoleucine and valine. MJ1267 is a branched-chain amino acid transporter with 29% similarity to both the LivF and LivG components of the E...; Region: ABC_Mj1267_LivG_branched; cd03219 114615009680 Walker A/P-loop; other site 114615009681 ATP binding site [chemical binding]; other site 114615009682 Q-loop/lid; other site 114615009683 ABC transporter signature motif; other site 114615009684 Walker B; other site 114615009685 D-loop; other site 114615009686 H-loop/switch region; other site 114615009687 LivF (TM1139) is part of the LIV-I bacterial ABC-type two-component transport system that imports neutral, branched-chain amino acids. The E. coli branched-chain amino acid transporter comprises a heterodimer of ABC transporters (LivF and LivG), a...; Region: ABC_TM1139_LivF_branched; cd03224 114615009688 Walker A/P-loop; other site 114615009689 ATP binding site [chemical binding]; other site 114615009690 Q-loop/lid; other site 114615009691 ABC transporter signature motif; other site 114615009692 Walker B; other site 114615009693 D-loop; other site 114615009694 H-loop/switch region; other site 114615009695 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 114615009696 TM-ABC transporter signature motif; other site 114615009697 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 114615009698 TM-ABC transporter signature motif; other site 114615009699 ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683 114615009700 Type I periplasmic ligand-binding domain of uncharacterized ABC (Atpase Binding Cassette)-type active transport systems that are predicted to be involved in uptake of amino acids, peptides, or inorganic ions; Region: PBP1_ABC_ligand_binding_like_10; cd06345 114615009701 putative ligand binding site [chemical binding]; other site 114615009702 dihydrolipoamide succinyltransferase; Provisional; Region: PTZ00144 114615009703 Glycosyl hydrolase family 1; Region: Glyco_hydro_1; pfam00232 114615009704 Beta-glucosidase/6-phospho-beta-glucosidase/beta- galactosidase [Carbohydrate transport and metabolism]; Region: BglB; cl01046 114615009705 Nitrile hydratase, alpha chain; Region: NHase_alpha; pfam02979 114615009706 TOMM propeptide domain; Region: TOMM_pelo; TIGR03793 114615009707 TOMM propeptide domain; Region: TOMM_pelo; TIGR03793 114615009708 Nitrile hydratase beta subunit; Region: NHase_beta; pfam02211 114615009709 nitrile hydratase, beta subunit; Region: nitrile_beta; cl03486 114615009710 nitrile hydratase, beta subunit; Region: nitrile_beta; cl03486 114615009711 ExsB is a transcription regulator related protein. It is a subfamily of a Adenosine nucleotide binding superfamily of proteins. This protein family is represented by a single member in nearly every completed large (> 1000 genes) prokaryotic genome. In...; Region: ExsB; cd01995 114615009712 Ligand Binding Site [chemical binding]; other site 114615009713 nucleoside triphosphate pyrophosphohydrolase; Reviewed; Region: mazG; PRK09562 114615009714 MazG nucleotide pyrophosphohydrolase domain; Region: MazG; cl00345 114615009715 MazG nucleotide pyrophosphohydrolase domain; Region: MazG; cl00345 114615009716 Peptidase M15; Region: Peptidase_M15_3; cl01194 114615009717 GTP-binding protein HflX; Region: GTP_HflX; TIGR03156 114615009718 HflX subfamily. A distinct conserved domain with a glycine-rich segment N-terminal of the GTPase domain characterizes the HflX subfamily. The E. coli HflX has been implicated in the control of the lambda cII repressor proteolysis, but the actual...; Region: HflX; cd01878 114615009719 G1 box; other site 114615009720 GTP/Mg2+ binding site [chemical binding]; other site 114615009721 Switch I region; other site 114615009722 G2 box; other site 114615009723 G3 box; other site 114615009724 Switch II region; other site 114615009725 G4 box; other site 114615009726 G5 box; other site 114615009727 Hfq, an abundant, ubiquitous RNA-binding protein, functions as a pleiotrophic regulator of RNA metabolism in prokaryotes, required for transcription of some transcripts and degradation of others. Hfq binds small RNA molecules called riboregulators that...; Region: Hfq; cd01716 114615009728 Sm1 motif; other site 114615009729 intra - hexamer interaction site; other site 114615009730 inter - hexamer interaction site [polypeptide binding]; other site 114615009731 nucleotide binding pocket [chemical binding]; other site 114615009732 Sm2 motif; other site 114615009733 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204 114615009734 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156 114615009735 active site 114615009736 phosphorylation site [posttranslational modification] 114615009737 intermolecular recognition site; other site 114615009738 dimerization interface [polypeptide binding]; other site 114615009739 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes...; Region: AAA; cd00009 114615009740 Walker A motif; other site 114615009741 ATP binding site [chemical binding]; other site 114615009742 Walker B motif; other site 114615009743 arginine finger; other site 114615009744 Bacterial regulatory protein, Fis family; Region: HTH_8; cl01091 114615009745 Signal transduction histidine kinase involved in nitrogen fixation and metabolism regulation [Signal transduction mechanisms]; Region: NtrY; COG5000 114615009746 Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices connected by an extended linker. The...; Region: HAMP; cl01054 114615009747 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459 114615009748 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via trans-...; Region: HisKA; cl00080 114615009749 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 114615009750 ATP binding site [chemical binding]; other site 114615009751 Mg2+ binding site [ion binding]; other site 114615009752 G-X-G motif; other site 114615009753 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 114615009754 Transcriptional regulator [Transcription]; Region: IclR; COG1414 114615009755 hypothetical protein; Validated; Region: PRK06201 114615009756 Demethylmenaquinone methyltransferase; Region: Methyltransf_6; cl00480 114615009757 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 114615009758 4-hydroxyphenylacetate permease; Region: HpaX; TIGR02332 114615009759 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 114615009760 putative substrate translocation pore; other site 114615009761 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 114615009762 Predicted metal-dependent hydrolase of the TIM-barrel fold [General function prediction only]; Region: COG3618 114615009763 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have...; Region: metallo-dependent_hydrolases; cl00281 114615009764 active site 114615009765 Gluconolactonase [Carbohydrate transport and metabolism]; Region: COG3386 114615009766 Predicted metal-dependent hydrolase of the TIM-barrel fold [General function prediction only]; Region: COG3618 114615009767 2-pyrone-4,6-dicarboxylic acid (PDC) hydrolase hydrolyzes PDC to yield 4-oxalomesaconic acid (OMA) or its tautomer, 4-carboxy-2-hydroxymuconic acid (CHM). This reaction is part of the protocatechuate (PCA) 4,5-cleavage pathway. PCA is one of the most...; Region: PDC_hydrolase; cd01311 114615009768 active site 114615009769 4-hydroxyphenylacetate permease; Region: HpaX; TIGR02332 114615009770 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 114615009771 putative substrate translocation pore; other site 114615009772 nitrogen regulation protein NR(I); Region: ntrC; TIGR01818 114615009773 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156 114615009774 active site 114615009775 phosphorylation site [posttranslational modification] 114615009776 intermolecular recognition site; other site 114615009777 dimerization interface [polypeptide binding]; other site 114615009778 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes...; Region: AAA; cd00009 114615009779 Walker A motif; other site 114615009780 ATP binding site [chemical binding]; other site 114615009781 Walker B motif; other site 114615009782 Bacterial regulatory protein, Fis family; Region: HTH_8; cl01091 114615009783 Signal transduction histidine kinase, nitrogen specific [Signal transduction mechanisms]; Region: NtrB; COG3852 114615009784 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459 114615009785 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via trans-...; Region: HisKA; cd00082 114615009786 dimer interface [polypeptide binding]; other site 114615009787 phosphorylation site [posttranslational modification] 114615009788 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 114615009789 ATP binding site [chemical binding]; other site 114615009790 Mg2+ binding site [ion binding]; other site 114615009791 G-X-G motif; other site 114615009792 putative TIM-barrel protein, nifR3 family; Region: nifR3_yhdG; TIGR00737 114615009793 Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and...; Region: DUS_like_FMN; cd02801 114615009794 FMN binding site [chemical binding]; other site 114615009795 active site 114615009796 catalytic residues [active] 114615009797 substrate binding site [chemical binding]; other site 114615009798 bifunctional 2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase/2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase protein; Provisional; Region: ispDF; PRK09382 114615009799 CDP-ME synthetase is involved in mevalonate-independent isoprenoid production; Region: CDP-ME_synthetase; cd02516 114615009800 substrate binding site [chemical binding]; other site 114615009801 dimer interface [polypeptide binding]; other site 114615009802 MECDP_synthase (2-C-methyl-D-erythritol-2,4-cyclodiphosphate synthase), encoded by the ispF gene, catalyzes the formation of 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (MEC) in the non-mevalonate deoxyxylulose (DOXP) pathway for isoprenoid...; Region: MECDP_synthase; cd00554 114615009803 homotrimer interaction site [polypeptide binding]; other site 114615009804 zinc binding site [ion binding]; other site 114615009805 CDP-binding sites; other site 114615009806 Competence-damaged protein; Region: CinA; cl00666 114615009807 Guanosine polyphosphate pyrophosphohydrolases/synthetases [Signal transduction mechanisms / Transcription]; Region: SpoT; COG0317 114615009808 PAS domain S-box; Region: sensory_box; TIGR00229 114615009809 Taxis toward Aspartate and Related amino acids and Homologs (TarH). The Tar chemoreceptor of Escherichia coli mediates attractant responses to aspartate, maltose, and phenol, repellent responses to Ni2+ and Co2+, and thermoresponses. These...; Region: TarH; cl00144 114615009810 Coenzyme Q-binding protein COQ10p and similar proteins; Region: COQ10p_like; cd07813 114615009811 putative coenzyme Q binding site [chemical binding]; other site 114615009812 lipoyl synthase; Provisional; Region: PRK05481 114615009813 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster...; Region: Radical_SAM; cd01335 114615009814 FeS/SAM binding site; other site 114615009815 Alkyladenine DNA glycosylase catalyzes the first step in base excision repair; Region: AAG; cd00540 114615009816 DNA binding site [nucleotide binding] 114615009817 active site 114615009818 valyl-tRNA synthetase; Reviewed; Region: valS; PRK05729 114615009819 catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817 114615009820 HIGH motif; other site 114615009821 catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817 114615009822 active site 114615009823 KMSKS motif; other site 114615009824 Anticodon-binding domain of valyl tRNA synthetases; Region: Anticodon_Ia_Val; cd07962 114615009825 tRNA binding surface [nucleotide binding]; other site 114615009826 anticodon binding site; other site 114615009827 Valyl tRNA synthetase tRNA binding arm; Region: Val_tRNA-synt_C; pfam10458 114615009828 Protein of unknown function (DUF2497); Region: DUF2497; cl11534 114615009829 type I secretion outer membrane protein, TolC family; Region: type_I_sec_TolC; TIGR01844 114615009830 Outer membrane efflux protein; Region: OEP; pfam02321 114615009831 Outer membrane efflux protein; Region: OEP; pfam02321 114615009832 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cl12011 114615009833 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_17; cd04676 114615009834 nudix motif; other site 114615009835 phosphonate utilization associated putative membrane protein; Region: phn_DUF6; TIGR03340 114615009836 Response regulator receiver domain; Region: Response_reg; pfam00072 114615009837 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156 114615009838 active site 114615009839 phosphorylation site [posttranslational modification] 114615009840 intermolecular recognition site; other site 114615009841 dimerization interface [polypeptide binding]; other site 114615009842 Response regulator receiver domain; Region: Response_reg; pfam00072 114615009843 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156 114615009844 active site 114615009845 phosphorylation site [posttranslational modification] 114615009846 intermolecular recognition site; other site 114615009847 dimerization interface [polypeptide binding]; other site 114615009848 PQQ-dependent dehydrogenase, methanol/ethanol family; Region: PQQ_enz_alc_DH; TIGR03075 114615009849 Dehydrogenases with pyrrolo-quinoline quinone (PQQ) as cofactor, like ethanol, methanol, and membrane bound glucose dehydrogenases. The alignment model contains an 8-bladed beta-propeller; Region: PQQ_DH; cl11493 114615009850 Trp docking motif; other site 114615009851 'Velcro' closure; other site 114615009852 active site 114615009853 Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1)...; Region: Rieske; cd03467 114615009854 iron-sulfur cluster [ion binding]; other site 114615009855 [2Fe-2S] cluster binding site [ion binding]; other site 114615009856 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 114615009857 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 114615009858 ligand binding site [chemical binding]; other site 114615009859 DTW domain; Region: DTW; cl01221 114615009860 multidrug efflux system subunit MdtC; Provisional; Region: PRK10614 114615009861 multidrug efflux system subunit MdtB; Provisional; Region: PRK10503 114615009862 multidrug efflux system subunit MdtA; Provisional; Region: PRK11556 114615009863 NodT family; Region: outer_NodT; TIGR01845 114615009864 Outer membrane efflux protein; Region: OEP; pfam02321 114615009865 Outer membrane efflux protein; Region: OEP; pfam02321 114615009866 Predicted NAD/FAD-binding protein [General function prediction only]; Region: COG2907 114615009867 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 114615009868 Protein of unknown function (DUF1365); Region: DUF1365; cl01388 114615009869 Cyclopropane fatty acid synthase and related methyltransferases [Cell envelope biogenesis, outer membrane]; Region: Cfa; COG2230 114615009870 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cl12011 114615009871 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 114615009872 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine...; Region: CBS_like; cd01561 114615009873 dimer interface [polypeptide binding]; other site 114615009874 pyridoxal 5'-phosphate binding site [chemical binding]; other site 114615009875 catalytic residue [active] 114615009876 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 114615009877 HisP and GlnQ are the ATP-binding components of the bacterial periplasmic histidine and glutamine permeases, repectively. Histidine permease is a multisubunit complex containing the HisQ and HisM integral membrane subunits and two copies of HisP; Region: ABC_HisP_GlnQ_permeases; cd03262 114615009878 Walker A/P-loop; other site 114615009879 ATP binding site [chemical binding]; other site 114615009880 Q-loop/lid; other site 114615009881 ABC transporter signature motif; other site 114615009882 Walker B; other site 114615009883 D-loop; other site 114615009884 H-loop/switch region; other site 114615009885 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261 114615009886 dimer interface [polypeptide binding]; other site 114615009887 conserved gate region; other site 114615009888 putative PBP binding loops; other site 114615009889 ABC-ATPase subunit interface; other site 114615009890 ABC-type amino acid transport system, permease component [Amino acid transport and metabolism]; Region: BatB; COG4597 114615009891 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cl00427 114615009892 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cl00427 114615009893 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and...; Region: PBPb; cd00134 114615009894 Bacterial periplasmic substrate-binding proteins; Region: PBPb; smart00062 114615009895 substrate binding pocket [chemical binding]; other site 114615009896 membrane-bound complex binding site; other site 114615009897 hinge residues; other site 114615009898 cystathionine beta-lyase; Provisional; Region: PRK05967 114615009899 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 114615009900 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 114615009901 catalytic residue [active] 114615009902 Na+/phosphate symporter [Inorganic ion transport and metabolism]; Region: NptA; COG1283 114615009903 Na+/Pi-cotransporter; Region: Na_Pi_cotrans; pfam02690 114615009904 PhoU domain; Region: PhoU; pfam01895 114615009905 PhoU domain; Region: PhoU; pfam01895 114615009906 Lipid A Biosynthesis N-terminal domain; Region: LAB_N; cl01627 114615009907 DPM_DPG-synthase_like is a member of the Glycosyltransferase 2 superfamily; Region: DPM_DPG-synthase_like; cd04179 114615009908 Ligand binding site [chemical binding]; other site 114615009909 Putative Catalytic site [active] 114615009910 DXD motif; other site 114615009911 PAP2_like proteins, a super-family of histidine phosphatases and vanadium haloperoxidases, includes type 2 phosphatidic acid phosphatase or lipid phosphate phosphatase (LPP), Glucose-6-phosphatase, Phosphatidylglycerophosphatase B and bacterial acid...; Region: PAP2_like; cl00474 114615009912 active site 114615009913 4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family [Cell envelope biogenesis, outer membrane]; Region: ArnT; COG1807 114615009914 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT; cl01961 114615009915 penicillin-binding protein 1C; Region: PBP_1c; TIGR02073 114615009916 Transglycosylase; Region: Transgly; cl07896 114615009917 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01039 114615009918 Penicillin-Binding Protein C-terminus Family; Region: BiPBP_C; pfam06832 114615009919 Large extracellular alpha-helical protein [General function prediction only]; Region: COG2373 114615009920 MG2 domain; Region: A2M_N; pfam01835 114615009921 Alpha-2-macroglobulin family N-terminal region; Region: A2M_N_2; pfam07703 114615009922 Alpha-2-macroglobulin family; Region: A2M; pfam00207 114615009923 Proteins similar to alpha2-macroglobulin (alpha (2)-M). Alpha (2)-M is a major carrier protein in serum. It is a broadly specific proteinase inhibitor. The structural thioester of alpha (2)-M, is involved in the immobilization and entrapment of...; Region: A2M_like; cd02891 114615009924 surface patch; other site 114615009925 thioester region; other site 114615009926 specificity defining residues; other site 114615009927 Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cl02788 114615009928 Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cd00338 114615009929 catalytic nucleophile [active] 114615009930 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cl12011 114615009931 Photosynthetic reaction center (RC) complex, subunit H; RC is an integral membrane protein-pigment complex which catalyzes light-induced reduction of ubiquinone to ubiquinol, generating a transmembrane electrochemical gradient of protons used to...; Region: PRCH; cl09959 114615009932 oxidoreductase; Provisional; Region: PRK06128 114615009933 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 114615009934 NAD(P) binding site [chemical binding]; other site 114615009935 active site 114615009936 Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices connected by an extended linker. The...; Region: HAMP; cl01054 114615009937 Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices connected by an extended linker. The...; Region: HAMP; cl01054 114615009938 Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices connected by an extended linker. The...; Region: HAMP; cl01054 114615009939 Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840 114615009940 Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices connected by an extended linker. The...; Region: HAMP; cl01054 114615009941 Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices connected by an extended linker. The...; Region: HAMP; cl01054 114615009942 Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices connected by an extended linker. The...; Region: HAMP; cl01054 114615009943 Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices connected by an extended linker. The...; Region: HAMP; cl01054 114615009944 Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840 114615009945 Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices connected by an extended linker. The...; Region: HAMP; cl01054 114615009946 Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices connected by an extended linker. The...; Region: HAMP; cl01054 114615009947 Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices connected by an extended linker. The...; Region: HAMP; cl01054 114615009948 Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices connected by an extended linker. The...; Region: HAMP; cl01054 114615009949 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 114615009950 GAF domain; Region: GAF; cl00853 114615009951 hybrid sensory kinase in two-component regulatory system with RcsB and YojN; Provisional; Region: PRK10841 114615009952 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via trans-...; Region: HisKA; cl00080 114615009953 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 114615009954 ATP binding site [chemical binding]; other site 114615009955 Mg2+ binding site [ion binding]; other site 114615009956 G-X-G motif; other site 114615009957 Response regulator receiver domain; Region: Response_reg; pfam00072 114615009958 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156 114615009959 active site 114615009960 phosphorylation site [posttranslational modification] 114615009961 intermolecular recognition site; other site 114615009962 dimerization interface [polypeptide binding]; other site 114615009963 Response regulator receiver domain; Region: Response_reg; pfam00072 114615009964 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156 114615009965 active site 114615009966 phosphorylation site [posttranslational modification] 114615009967 intermolecular recognition site; other site 114615009968 dimerization interface [polypeptide binding]; other site 114615009969 Response regulator receiver domain; Region: Response_reg; pfam00072 114615009970 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156 114615009971 active site 114615009972 phosphorylation site [posttranslational modification] 114615009973 intermolecular recognition site; other site 114615009974 dimerization interface [polypeptide binding]; other site 114615009975 Response regulator receiver domain; Region: Response_reg; pfam00072 114615009976 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156 114615009977 active site 114615009978 phosphorylation site [posttranslational modification] 114615009979 intermolecular recognition site; other site 114615009980 dimerization interface [polypeptide binding]; other site 114615009981 PAS fold; Region: PAS_3; pfam08447 114615009982 Motif C-terminal to PAS motifs (likely to contribute to PAS structural domain); Region: PAC; smart00086 114615009983 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920 114615009984 Histidine kinase; Region: HisKA_2; cl06527 114615009985 oxidoreductase alpha (molybdopterin) subunit; Region: Fdhalpha-like; TIGR01701 114615009986 The MopB_ydeP CD includes a group of related uncharacterized bacterial molybdopterin-binding oxidoreductase-like domains with a putative molybdopterin cofactor binding site. These members belong to the molybdopterin_binding (MopB) superfamily of proteins; Region: MopB_ydeP; cd02767 114615009987 putative molybdopterin cofactor binding site [chemical binding]; other site 114615009988 The MopB_CT_ydeP CD includes a group of related uncharacterized bacterial molybdopterin-binding oxidoreductase-like domains with a putative molybdopterin cofactor binding site. This CD is of the conserved molybdopterin_binding C-terminal (MopB_CT)...; Region: MopB_CT_ydeP; cd02787 114615009989 putative molybdopterin cofactor binding site; other site 114615009990 A type 1 glutamine amidotransferase (GATase1)-like domain found in PfpI from Pyrococcus furiosus; Region: GATase1_PfpI_like; cd03134 114615009991 proposed catalytic triad [active] 114615009992 conserved cys residue [active] 114615009993 Protein of unknown function (DUF3072); Region: DUF3072; pfam11272 114615009994 Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; cl07971 114615009995 DNA-binding response regulator CreB; Provisional; Region: PRK11083 114615009996 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156 114615009997 active site 114615009998 phosphorylation site [posttranslational modification] 114615009999 intermolecular recognition site; other site 114615010000 dimerization interface [polypeptide binding]; other site 114615010001 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase...; Region: trans_reg_C; cd00383 114615010002 DNA binding site [nucleotide binding] 114615010003 Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices connected by an extended linker. The...; Region: HAMP; cl01054 114615010004 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via trans-...; Region: HisKA; cl00080 114615010005 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 114615010006 ATP binding site [chemical binding]; other site 114615010007 Mg2+ binding site [ion binding]; other site 114615010008 G-X-G motif; other site 114615010009 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 114615010010 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_13; cd08517 114615010011 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 114615010012 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261 114615010013 dimer interface [polypeptide binding]; other site 114615010014 conserved gate region; other site 114615010015 putative PBP binding loops; other site 114615010016 ABC-ATPase subunit interface; other site 114615010017 nickel ABC transporter, permease subunit NikC; Region: nickel_nikC; TIGR02790 114615010018 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261 114615010019 dimer interface [polypeptide binding]; other site 114615010020 conserved gate region; other site 114615010021 putative PBP binding loops; other site 114615010022 ABC-ATPase subunit interface; other site 114615010023 ATPase components of various ABC-type transport systems, contain duplicated ATPase [General function prediction only]; Region: COG1123 114615010024 The ABC transporter subfamily specific for the transport of dipeptides, oligopeptides (OppD), and nickel (NikDE). The NikABCDE system of E. coli belongs to this family and is composed of the periplasmic binding protein NikA, two integral membrane...; Region: ABC_NikE_OppD_transporters; cd03257 114615010025 Walker A/P-loop; other site 114615010026 ATP binding site [chemical binding]; other site 114615010027 Q-loop/lid; other site 114615010028 ABC transporter signature motif; other site 114615010029 Walker B; other site 114615010030 D-loop; other site 114615010031 H-loop/switch region; other site 114615010032 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 114615010033 The ABC transporter subfamily specific for the transport of dipeptides, oligopeptides (OppD), and nickel (NikDE). The NikABCDE system of E. coli belongs to this family and is composed of the periplasmic binding protein NikA, two integral membrane...; Region: ABC_NikE_OppD_transporters; cd03257 114615010034 Walker A/P-loop; other site 114615010035 ATP binding site [chemical binding]; other site 114615010036 Q-loop/lid; other site 114615010037 ABC transporter signature motif; other site 114615010038 Walker B; other site 114615010039 D-loop; other site 114615010040 H-loop/switch region; other site 114615010041 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 114615010042 Malate:quinone oxidoreductase (Mqo); Region: Mqo; cl14881 114615010043 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 114615010044 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 114615010045 active site 114615010046 metal binding site [ion binding]; metal-binding site 114615010047 CDP-6-deoxy-delta-3,4-glucoseen reductase; Validated; Region: PRK07609 114615010048 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 114615010049 catalytic loop [active] 114615010050 iron binding site [ion binding]; other site 114615010051 Iron-sulfur binding ferredoxin reductase (FNR) proteins combine the FAD and NAD(P) binding regions of FNR with an N-terminal Iron-Sulfur binding cluster domain. Ferredoxin-NADP+ (oxido)reductase is an FAD-containing enzyme that catalyzes the reversible...; Region: FNR_N-term_Iron_sulfur_binding; cd06194 114615010052 FAD binding pocket [chemical binding]; other site 114615010053 FAD binding motif [chemical binding]; other site 114615010054 phosphate binding motif [ion binding]; other site 114615010055 beta-alpha-beta structure motif; other site 114615010056 NAD binding pocket [chemical binding]; other site 114615010057 Cytochrome b (N-terminus)/b6/petB: Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria...; Region: Cytochrome_b_N; cl00859 114615010058 DOMON-like domain of an uncharacterized protein family; Region: DOMON_like_cytochrome; cd09625 114615010059 putative ligand binding site [chemical binding]; other site 114615010060 ABC-type protease/lipase transport system, ATPase and permease components [General function prediction only]; Region: ArpD; COG4618 114615010061 ABC transporter transmembrane region; Region: ABC_membrane; cl00549 114615010062 This family represents the ABC component of the protease secretion system PrtD, a 60-kDa integral membrane protein sharing 37% identity with HlyB, the ABC component of the alpha-hemolysin secretion pathway, in the C-terminal domain. They export...; Region: ABCC_Protease_Secretion; cd03246 114615010063 Walker A/P-loop; other site 114615010064 ATP binding site [chemical binding]; other site 114615010065 Q-loop/lid; other site 114615010066 ABC transporter signature motif; other site 114615010067 Walker B; other site 114615010068 D-loop; other site 114615010069 H-loop/switch region; other site 114615010070 type I secretion membrane fusion protein, HlyD family; Region: type_I_hlyD; TIGR01843 114615010071 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 114615010072 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi...; Region: TPR; cd00189 114615010073 TPR motif; other site 114615010074 Flp pilus assembly protein TadD, contains TPR repeats [Intracellular trafficking and secretion]; Region: TadD; COG5010 114615010075 binding surface 114615010076 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi...; Region: TPR; cd00189 114615010077 binding surface 114615010078 TPR motif; other site 114615010079 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi...; Region: TPR; cd00189 114615010080 TPR motif; other site 114615010081 binding surface 114615010082 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi...; Region: TPR; cd00189 114615010083 binding surface 114615010084 TPR motif; other site 114615010085 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi...; Region: TPR; cd00189 114615010086 binding surface 114615010087 TPR motif; other site 114615010088 Sulfotransferase domain; Region: Sulfotransfer_1; pfam00685 114615010089 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi...; Region: TPR; cd00189 114615010090 binding surface 114615010091 TPR motif; other site 114615010092 FOG: TPR repeat [General function prediction only]; Region: NrfG; COG0457 114615010093 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi...; Region: TPR; cd00189 114615010094 binding surface 114615010095 TPR motif; other site 114615010096 Sulfotransferase domain; Region: Sulfotransfer_1; pfam00685 114615010097 Formyl transferase catalytic core domain found in a group of proteins with unknown functions; Region: FMT_core_like_2; cd08822 114615010098 putative active site [active] 114615010099 putative substrate binding site [chemical binding]; other site 114615010100 putative cosubstrate binding site; other site 114615010101 catalytic site [active] 114615010102 EamA-like transporter family; Region: EamA; cl01037 114615010103 Caspase, interleukin-1 beta converting enzyme (ICE) homologues; Cysteine-dependent aspartate-directed proteases that mediate programmed cell death (apoptosis). Caspases are synthesized as inactive zymogens and activated by proteolysis of the peptide...; Region: CASc; cl00042 114615010104 substrate pocket [chemical binding]; other site 114615010105 active site 114615010106 proteolytic cleavage site; other site 114615010107 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 114615010108 Caspase, interleukin-1 beta converting enzyme (ICE) homologues; Cysteine-dependent aspartate-directed proteases that mediate programmed cell death (apoptosis). Caspases are synthesized as inactive zymogens and activated by proteolysis of the peptide...; Region: CASc; cl00042 114615010109 active site 114615010110 substrate pocket [chemical binding]; other site 114615010111 proteolytic cleavage site; other site 114615010112 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 114615010113 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 114615010114 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459 114615010115 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via trans-...; Region: HisKA; cl00080 114615010116 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 114615010117 ATP binding site [chemical binding]; other site 114615010118 Mg2+ binding site [ion binding]; other site 114615010119 G-X-G motif; other site 114615010120 Response regulator receiver domain; Region: Response_reg; pfam00072 114615010121 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156 114615010122 active site 114615010123 phosphorylation site [posttranslational modification] 114615010124 intermolecular recognition site; other site 114615010125 dimerization interface [polypeptide binding]; other site 114615010126 circadian clock protein KaiC; Reviewed; Region: PRK09302 114615010127 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 114615010128 Walker A motif; other site 114615010129 ATP binding site [chemical binding]; other site 114615010130 Walker B motif; other site 114615010131 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 114615010132 Walker A motif; other site 114615010133 ATP binding site [chemical binding]; other site 114615010134 Walker B motif; other site 114615010135 KaiB-like family; composed of the circadian clock proteins, KaiB and the N-terminal KaiB-like sensory domain of SasA. KaiB is an essential protein in maintaining circadian rhythm. It was originally discovered from the cyanobacterium Synechococcus as...; Region: KaiB_like; cd02978 114615010136 tetramer interface [polypeptide binding]; other site 114615010137 dimer interface [polypeptide binding]; other site 114615010138 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156 114615010139 active site 114615010140 phosphorylation site [posttranslational modification] 114615010141 intermolecular recognition site; other site 114615010142 dimerization interface [polypeptide binding]; other site 114615010143 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3514 114615010144 cysteine synthases; Region: cysKM; TIGR01136 114615010145 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine...; Region: CBS_like; cd01561 114615010146 dimer interface [polypeptide binding]; other site 114615010147 pyridoxal 5'-phosphate binding site [chemical binding]; other site 114615010148 catalytic residue [active] 114615010149 Queuine tRNA-ribosyltransferase; Region: TGT; cl00409 114615010150 aspartate-semialdehyde dehydrogenase; Provisional; Region: PRK14874 114615010151 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 114615010152 Semialdehyde dehydrogenase, dimerisation domain; Region: Semialdhyde_dhC; pfam02774 114615010153 Queuosine biosynthesis protein; Region: Queuosine_synth; cl00523 114615010154 S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Provisional; Region: queA; PRK00147 114615010155 cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the...; Region: cyclophilin; cd00317 114615010156 active site 114615010157 cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the...; Region: cyclophilin; cd00317 114615010158 active site 114615010159 Nicotinic acid mononucleotide adenylyltransferase [Coenzyme metabolism]; Region: NadD; COG1057 114615010160 Phosphopantetheine adenylyltransferase; Region: PPAT; cd02163 114615010161 active site 114615010162 (T/H)XGH motif; other site 114615010163 DNA gyrase subunit A; Validated; Region: PRK05560 114615010164 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes in...; Region: TOP4c; cd00187 114615010165 CAP-like domain; other site 114615010166 Active site [active] 114615010167 primary dimer interface [polypeptide binding]; other site 114615010168 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 114615010169 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 114615010170 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 114615010171 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 114615010172 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 114615010173 Transcriptional regulator [Transcription]; Region: LysR; COG0583 114615010174 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 114615010175 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_5; cd08474 114615010176 putative effector binding pocket; other site 114615010177 putative dimerization interface [polypeptide binding]; other site 114615010178 Predicted oxidoreductases (related to aryl-alcohol dehydrogenases) [Energy production and conversion]; Region: Tas; COG0667 114615010179 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and...; Region: Aldo_ket_red; cd06660 114615010180 active site 114615010181 catalytic tetrad [active] 114615010182 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 114615010183 dimer interface [polypeptide binding]; other site 114615010184 ssDNA binding site [nucleotide binding]; other site 114615010185 tetramer (dimer of dimers) interface [polypeptide binding]; other site 114615010186 Surface antigen; Region: Surface_Ag_2; cl01155 114615010187 Surface antigen; Region: Surface_Ag_2; cl01155 114615010188 Surface antigen; Region: Surface_Ag_2; cl01155 114615010189 Surface antigen; Region: Surface_Ag_2; cl01155 114615010190 Surface antigen; Region: Surface_Ag_2; cl01155 114615010191 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 114615010192 excinuclease ABC subunit A; Reviewed; Region: uvrA; PRK00349 114615010193 The excision repair protein UvrA domain I; Nucleotide excision repair in eubacteria is a process that repairs DNA damage by the removal of a 12-13-mer oligonucleotide containing the lesion. Recognition and cleavage of the damaged DNA is a multistep...; Region: ABC_UvrA_I; cd03270 114615010194 The excision repair protein UvrA domain I; Nucleotide excision repair in eubacteria is a process that repairs DNA damage by the removal of a 12-13-mer oligonucleotide containing the lesion. Recognition and cleavage of the damaged DNA is a multistep...; Region: ABC_UvrA_I; cd03270 114615010195 The excision repair protein UvrA domain II; Nucleotide excision repair in eubacteria is a process that repairs DNA damage by the removal of a 12-13-mer oligonucleotide containing the lesion. Recognition and cleavage of the damaged DNA is a multistep...; Region: ABC_UvrA_II; cd03271 114615010196 Predicted phosphatases [General function prediction only]; Region: Gph; COG0546 114615010197 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others...; Region: HAD_like; cl11391 114615010198 PQQ-dependent catabolism-associated beta-propeller protein; Region: PQQ_ABC_repeats; TIGR03866 114615010199 40-residue YVTN family beta-propeller repeat; Region: beta_rpt_yvtn; TIGR02276 114615010200 40-residue YVTN family beta-propeller repeat; Region: beta_rpt_yvtn; TIGR02276 114615010201 40-residue YVTN family beta-propeller repeat; Region: beta_rpt_yvtn; TIGR02276 114615010202 40-residue YVTN family beta-propeller repeat; Region: beta_rpt_yvtn; TIGR02276 114615010203 40-residue YVTN family beta-propeller repeat; Region: beta_rpt_yvtn; TIGR02276 114615010204 Pyrabactin resistance 1 (PYR1), PYR1-like (PYL), regulatory component of abscisic acid receptors (RCARs), and related proteins; Region: PYR_PYL_RCAR_like; cd07821 114615010205 putative hydrophobic ligand binding site [chemical binding]; other site 114615010206 protein interface [polypeptide binding]; other site 114615010207 gate; other site 114615010208 Uncharacterised protein family (UPF0149); Region: UPF0149; cl01173 114615010209 hypothetical protein; Provisional; Region: PRK02250 114615010210 SEC-C motif; Region: SEC-C; cl12132 114615010211 Predicted ATPase [General function prediction only]; Region: COG3910 114615010212 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 114615010213 Walker A/P-loop; other site 114615010214 ATP binding site [chemical binding]; other site 114615010215 Q-loop/lid; other site 114615010216 ABC transporter signature motif; other site 114615010217 Walker B; other site 114615010218 D-loop; other site 114615010219 H-loop/switch region; other site 114615010220 acyl-CoA synthetase; Validated; Region: PRK07470 114615010221 Acyl-protein synthetase, LuxE; Region: LuxE; cl10450 114615010222 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 114615010223 Domain of unknown function (DUF1127); Region: DUF1127; cl02276 114615010224 Domain of unknown function (DUF3597); Region: DUF3597; pfam12200 114615010225 Predicted integral membrane protein (DUF2189); Region: DUF2189; cl02291 114615010226 lysozyme_like domain. This contains several members including Soluble Lytic Transglycosylases (SLT), Goose Egg-White Lysozymes (GEWL), Hen Egg-White Lysozymes (HEWL), chitinases, bacteriophage lambda lysozymes, endolysins, autolysins, and chitosanases...; Region: lysozyme_like; cl00222 114615010227 lytic murein transglycosylase; Region: MltB_2; TIGR02283 114615010228 Domain of unknown function (DUF1127); Region: DUF1127; cl02276 114615010229 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 114615010230 Glucose inhibited division protein A; Region: GIDA; pfam01134 114615010231 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 114615010232 Probable taurine catabolism dioxygenase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: TauD; COG2175 114615010233 Clavaminic acid synthetase (CAS) -like; CAS is a trifunctional Fe(II)/ 2-oxoglutarate (2OG) oxygenase carrying out three reactions in the biosynthesis of clavulanic acid, an inhibitor of class A serine beta-lactamases. In general, Fe(II)-2OG...; Region: CAS_like; cl00184 114615010234 active site 114615010235 iron coordination sites [ion binding]; other site 114615010236 substrate binding pocket [chemical binding]; other site 114615010237 Probable taurine catabolism dioxygenase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: TauD; COG2175 114615010238 Clavaminic acid synthetase (CAS) -like; CAS is a trifunctional Fe(II)/ 2-oxoglutarate (2OG) oxygenase carrying out three reactions in the biosynthesis of clavulanic acid, an inhibitor of class A serine beta-lactamases. In general, Fe(II)-2OG...; Region: CAS_like; cl00184 114615010239 Isoprenoid Biosynthesis enzymes, Class 1; Region: Isoprenoid_Biosyn_C1; cl00210 114615010240 substrate binding pocket [chemical binding]; other site 114615010241 substrate-Mg2+ binding site; other site 114615010242 aspartate-rich region 1; other site 114615010243 aspartate-rich region 2; other site 114615010244 Mth938-like domain. The members of this family include: Mth938, 2P1, Xcr35, Rpa2829, and several uncharacterized sequences. Mth938 is a hypothetical protein encoded by the Methanobacterium thermoautotrophicum (Mth) genome. This protein crystallizes as...; Region: Mth938-like; cd00248 114615010245 preprotein translocase subunit SecF; Reviewed; Region: secF; PRK13022 114615010246 SecD/SecF GG Motif; Region: Sec_GG; pfam07549 114615010247 Protein export membrane protein; Region: SecD_SecF; cl14618 114615010248 preprotein translocase subunit SecD; Reviewed; Region: secD; PRK05812 114615010249 Protein export membrane protein; Region: SecD_SecF; cl14618 114615010250 Preprotein translocase subunit; Region: YajC; cl00806 114615010251 Predicted ATPase (AAA+ superfamily) [General function prediction only]; Region: COG2607 114615010252 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 114615010253 Lysin domain, found in a variety of enzymes involved in bacterial cell wall degradation. This domain may have a general peptidoglycan binding function; Region: LysM; cl00107 114615010254 Lysin domain, found in a variety of enzymes involved in bacterial cell wall degradation. This domain may have a general peptidoglycan binding function; Region: LysM; cl00107 114615010255 Peptidase family M23; Region: Peptidase_M23; pfam01551 114615010256 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cd02440 114615010257 S-adenosylmethionine binding site [chemical binding]; other site 114615010258 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 114615010259 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156 114615010260 active site 114615010261 phosphorylation site [posttranslational modification] 114615010262 intermolecular recognition site; other site 114615010263 dimerization interface [polypeptide binding]; other site 114615010264 Survival protein SurE; Region: SurE; cl00448 114615010265 seryl-tRNA synthetase; Provisional; Region: PRK05431 114615010266 Seryl-tRNA synthetase N-terminal domain; Region: Seryl_tRNA_N; pfam02403 114615010267 Seryl-tRNA synthetase (SerRS) class II core catalytic domain. SerRS is responsible for the attachment of serine to the 3' OH group of ribose of the appropriate tRNA. This domain It is primarily responsible for ATP-dependent formation of the enzyme...; Region: SerRS_core; cd00770 114615010268 dimer interface [polypeptide binding]; other site 114615010269 active site 114615010270 motif 1; other site 114615010271 motif 2; other site 114615010272 motif 3; other site 114615010273 Sec-independent protein translocase protein (TatC); Region: TatC; cl00521 114615010274 mttA/Hcf106 family; Region: MttA_Hcf106; cl00788 114615010275 mttA/Hcf106 family; Region: MttA_Hcf106; cl00788 114615010276 Putative transcriptional regulators (Ypuh-like); Region: DUF387; cl00612 114615010277 ScpA/B protein; Region: ScpA_ScpB; cl00598 114615010278 Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; cl07971 114615010279 Sporulation related domain; Region: SPOR; cl10051 114615010280 arginyl-tRNA synthetase; Reviewed; Region: argS; PRK01611 114615010281 Arginyl tRNA synthetase N terminal domain; Region: Arg_tRNA_synt_N; cl04104 114615010282 catalytic core domain of arginyl-tRNA synthetases; Region: ArgRS_core; cd00671 114615010283 active site 114615010284 HIGH motif; other site 114615010285 KMSK motif region; other site 114615010286 Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020 114615010287 tRNA binding surface [nucleotide binding]; other site 114615010288 anticodon binding site; other site 114615010289 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cl00076 114615010290 Iron-sulphur cluster biosynthesis; Region: Fe-S_biosyn; cl00400 114615010291 Bacteriophytochrome (light-regulated signal transduction histidine kinase) [Signal transduction mechanisms]; Region: COG4251 114615010292 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via trans-...; Region: HisKA; cd00082 114615010293 dimer interface [polypeptide binding]; other site 114615010294 phosphorylation site [posttranslational modification] 114615010295 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 114615010296 ATP binding site [chemical binding]; other site 114615010297 Mg2+ binding site [ion binding]; other site 114615010298 G-X-G motif; other site 114615010299 Response regulator receiver domain; Region: Response_reg; pfam00072 114615010300 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156 114615010301 active site 114615010302 phosphorylation site [posttranslational modification] 114615010303 intermolecular recognition site; other site 114615010304 dimerization interface [polypeptide binding]; other site 114615010305 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 114615010306 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 114615010307 active site 114615010308 metal binding site [ion binding]; metal-binding site 114615010309 Transcriptional regulator [Transcription]; Region: LysR; COG0583 114615010310 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 114615010311 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 114615010312 putative effector binding pocket; other site 114615010313 dimerization interface [polypeptide binding]; other site 114615010314 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases [Coenzyme metabolism / Energy production and conversion]; Region: UbiH; COG0654 114615010315 Flavin Reductases; Region: FlaRed; cl00801 114615010316 Predicted oxidoreductases (related to aryl-alcohol dehydrogenases) [Energy production and conversion]; Region: Tas; COG0667 114615010317 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and...; Region: Aldo_ket_red; cd06660 114615010318 active site 114615010319 catalytic tetrad [active] 114615010320 Escherichia coli exonuclease III (ExoIII) and Neisseria meningitides NExo-like subfamily of the ExoIII family purinic/apyrimidinic (AP) endonucleases; Region: ExoIII-like_AP-endo; cd09086 114615010321 putative phosphate binding site [ion binding]; other site 114615010322 putative catalytic site [active] 114615010323 active site 114615010324 metal binding site A [ion binding]; metal-binding site 114615010325 DNA binding site [nucleotide binding] 114615010326 putative AP binding site [nucleotide binding]; other site 114615010327 putative metal binding site B [ion binding]; other site 114615010328 Beta-lactamase; Region: Beta-lactamase; cl01009 114615010329 UreD urease accessory protein; Region: UreD; cl00530 114615010330 Ras-like GTPase superfamily. The Ras-like superfamily of small GTPases consists of several families with an extremely high degree of structural and functional similarity. The Ras superfamily is divided into at least four families in eukaryotes: the Ras...; Region: Ras_like_GTPase; cl10444 114615010331 Ras-like GTPase superfamily. The Ras-like superfamily of small GTPases consists of several families with an extremely high degree of structural and functional similarity. The Ras superfamily is divided into at least four families in eukaryotes: the Ras...; Region: Ras_like_GTPase; cl10444 114615010332 G4 box; other site 114615010333 G5 box; other site 114615010334 urease subunit alpha; Reviewed; Region: ureC; PRK13308 114615010335 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have...; Region: metallo-dependent_hydrolases; cl00281 114615010336 active site 114615010337 bifunctional urease subunit gamma/beta; Reviewed; Region: PRK13192 114615010338 Urease gamma-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, archaea, fungi and plants. Their primary role is to allow the use...; Region: Urease_gamma; cd00390 114615010339 alpha-gamma subunit interface [polypeptide binding]; other site 114615010340 beta-gamma subunit interface [polypeptide binding]; other site 114615010341 Urease beta-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, archaea, fungi and plants. Their primary role is to allow the use...; Region: Urease_beta; cd00407 114615010342 gamma-beta subunit interface [polypeptide binding]; other site 114615010343 alpha-beta subunit interface [polypeptide binding]; other site 114615010344 Urease accessory protein UreF [Posttranslational modification, protein turnover, chaperones]; Region: UreF; COG0830 114615010345 UreF; Region: UreF; pfam01730 114615010346 UreE urease accessory protein. UreE is a metallochaperone assisting the insertion of a Ni2+ ion in the active site of urease, an important step in the in vivo assembly of urease, an enzyme that hydrolyses urea into ammonia and carbamic acid. The C-...; Region: UreE; cl03727 114615010347 dimer interface [polypeptide binding]; other site 114615010348 catalytic residues [active] 114615010349 Antibiotic biosynthesis monooxygenase; Region: ABM; cl10022 114615010350 GGCT-like domains, also called AIG2-like family. Gamma-glutamyl cyclotransferase (GGCT) catalyzes the formation of pyroglutamic acid (5-oxoproline) from dipeptides containing gamma-glutamyl, and is a dimeric protein. In Homo sapiens, the protein is...; Region: GGCT_like; cl11426 114615010351 amidase; Provisional; Region: PRK07139 114615010352 LivF (TM1139) is part of the LIV-I bacterial ABC-type two-component transport system that imports neutral, branched-chain amino acids. The E. coli branched-chain amino acid transporter comprises a heterodimer of ABC transporters (LivF and LivG), a...; Region: ABC_TM1139_LivF_branched; cd03224 114615010353 urea ABC transporter, ATP-binding protein UrtE; Region: urea_trans_UrtE; TIGR03410 114615010354 Walker A/P-loop; other site 114615010355 ATP binding site [chemical binding]; other site 114615010356 Q-loop/lid; other site 114615010357 ABC transporter signature motif; other site 114615010358 Walker B; other site 114615010359 D-loop; other site 114615010360 H-loop/switch region; other site 114615010361 urea ABC transporter, ATP-binding protein UrtD; Region: urea_trans_UrtD; TIGR03411 114615010362 The Mj1267/LivG ABC transporter subfamily is involved in the transport of the hydrophobic amino acids leucine, isoleucine and valine. MJ1267 is a branched-chain amino acid transporter with 29% similarity to both the LivF and LivG components of the E...; Region: ABC_Mj1267_LivG_branched; cd03219 114615010363 Walker A/P-loop; other site 114615010364 ATP binding site [chemical binding]; other site 114615010365 Q-loop/lid; other site 114615010366 ABC transporter signature motif; other site 114615010367 Walker B; other site 114615010368 D-loop; other site 114615010369 H-loop/switch region; other site 114615010370 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 114615010371 TM-ABC transporter signature motif; other site 114615010372 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 114615010373 TM-ABC transporter signature motif; other site 114615010374 ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683 114615010375 Periplasmic component (FmdD) of an active transport system for short-chain amides and urea (FmdDEF); Region: PBP1_Amide_Urea_BP_like; cd06356 114615010376 putative ligand binding site [chemical binding]; other site 114615010377 Type I periplasmic-binding protein of the nitrile hydratase (NHase) system that selectively converts nitriles to corresponding amides; Region: PBP1_NHase; cd06358 114615010378 putative ligand binding site [chemical binding]; other site 114615010379 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 114615010380 FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790 114615010381 Sel1 repeat; Region: Sel1; cl02723 114615010382 Dehydratase family; Region: ILVD_EDD; cl00340 114615010383 dihydroxy-acid dehydratase; Region: ilvD; TIGR00110 114615010384 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3181 114615010385 Tripartite tricarboxylate transporter family receptor; Region: TctC; cl15260 114615010386 threonine synthase; Validated; Region: PRK08197 114615010387 Threonine synthase is a pyridoxal phosphate (PLP) dependent enzyme that catalyses the last reaction in the synthesis of threonine from aspartate. It proceeds by converting O-phospho-L-homoserine (OPH) into threonine and inorganic phosphate. In plants...; Region: Thr-synth_1; cd01563 114615010388 homodimer interface [polypeptide binding]; other site 114615010389 pyridoxal 5'-phosphate binding site [chemical binding]; other site 114615010390 catalytic residue [active] 114615010391 dihydrolipoamide dehydrogenase; Reviewed; Region: PRK06416 114615010392 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 114615010393 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 114615010394 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 114615010395 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 114615010396 pyruvate dehydrogenase complex dihydrolipoamide acetyltransferase, long form; Region: PDHac_trf_mito; TIGR01349 114615010397 E3 interaction surface; other site 114615010398 lipoyl attachment site [posttranslational modification]; other site 114615010399 e3 binding domain; Region: E3_binding; pfam02817 114615010400 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; cl02008 114615010401 pyruvate dehydrogenase subunit beta; Provisional; Region: PRK11892 114615010402 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 114615010403 E3 interaction surface; other site 114615010404 lipoyl attachment site [posttranslational modification]; other site 114615010405 Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036 114615010406 alpha subunit interface [polypeptide binding]; other site 114615010407 TPP binding site [chemical binding]; other site 114615010408 heterodimer interface [polypeptide binding]; other site 114615010409 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 114615010410 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, alpha subunit [Energy production and conversion]; Region: AcoA; COG1071 114615010411 Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000 114615010412 tetramer interface [polypeptide binding]; other site 114615010413 TPP-binding site [chemical binding]; other site 114615010414 heterodimer interface [polypeptide binding]; other site 114615010415 phosphorylation loop region [posttranslational modification] 114615010416 Septum formation initiator; Region: DivIC; cl11433 114615010417 Class II Aldolase and Adducin head (N-terminal) domain. Aldolases are ubiquitous enzymes catalyzing central steps of carbohydrate metabolism. Based on enzymatic mechanisms, this superfamily has been divided into two distinct classes (Class I and II)...; Region: Aldolase_II; cl00214 114615010418 intersubunit interface [polypeptide binding]; other site 114615010419 active site 114615010420 Zn2+ binding site [ion binding]; other site 114615010421 NADPH-dependent FMN reductase; Region: FMN_red; cl00438 114615010422 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 114615010423 Beta-lactamase; Region: Beta-lactamase; cl01009 114615010424 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 114615010425 2-enoyl thioester reductase (ETR) like proteins, child 1; Region: ETR_like_1; cd08291 114615010426 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 114615010427 NADP binding site [chemical binding]; other site 114615010428 dimer interface [polypeptide binding]; other site 114615010429 enolase; Provisional; Region: eno; PRK00077 114615010430 Enolase: Enolases are homodimeric enzymes that catalyse the reversible dehydration of 2-phospho-D-glycerate to phosphoenolpyruvate as part of the glycolytic and gluconeogenesis pathways. The reaction is facilitated by the presence of metal ions; Region: enolase; cd03313 114615010431 dimer interface [polypeptide binding]; other site 114615010432 metal binding site [ion binding]; metal-binding site 114615010433 substrate binding pocket [chemical binding]; other site 114615010434 Tunnelling fold (T-fold). The five known T-folds are found in five different enzymes with different functions: dihydroneopterin-triphosphate epimerase (DHNTPE), dihydroneopterin aldolase (DHNA) , GTP cyclohydrolase I (GTPCH-1), 6-pyrovoyl...; Region: TFold; cl00263 114615010435 putative transposase OrfB; Reviewed; Region: PHA02517 114615010436 Integrase core domain; Region: rve; cl01316 114615010437 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 114615010438 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 114615010439 putative substrate translocation pore; other site 114615010440 DAHP synthetase I family; Region: DAHP_synth_1; pfam00793 114615010441 NeuB family; Region: NeuB; cl00496 114615010442 NIPSNAP; Region: NIPSNAP; pfam07978 114615010443 CTP synthetase; Validated; Region: pyrG; PRK05380 114615010444 CTP synthetase (CTPs) is a two-domain protein, which consists of an N-terminal synthetase domain and C-terminal glutaminase domain. The enzymes hydrolyze the amide bond of glutamine to ammonia and glutamate at the glutaminase domains and transfer...; Region: CTGs; cd03113 114615010445 Catalytic site [active] 114615010446 Active site [active] 114615010447 UTP binding site [chemical binding]; other site 114615010448 Type 1 glutamine amidotransferase (GATase1) domain found in Cytidine Triphosphate Synthetase; Region: GATase1_CTP_Synthase; cd01746 114615010449 active site 114615010450 putative oxyanion hole; other site 114615010451 catalytic triad [active] 114615010452 Preprotein translocase SecG subunit; Region: SecG; cl09123 114615010453 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 114615010454 non-specific DNA binding site [nucleotide binding]; other site 114615010455 salt bridge; other site 114615010456 sequence-specific DNA binding site [nucleotide binding]; other site 114615010457 Cupin domain; Region: Cupin_2; cl09118 114615010458 Triosephosphate isomerase (TIM) is a glycolytic enzyme that catalyzes the interconversion of dihydroxyacetone phosphate and D-glyceraldehyde-3-phosphate. The reaction is very efficient and requires neither cofactors nor metal ions. TIM, usually...; Region: TIM; cd00311 114615010459 substrate binding site [chemical binding]; other site 114615010460 dimer interface [polypeptide binding]; other site 114615010461 catalytic triad [active] 114615010462 periplasmic folding chaperone; Provisional; Region: PRK10788 114615010463 PPIC-type PPIASE domain; Region: Rotamase; cl08278 114615010464 anthranilate phosphoribosyltransferase; Provisional; Region: trpD; PRK00188 114615010465 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 114615010466 Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591 114615010467 Indole-3-glycerol phosphate synthase (IGPS); an enzyme in the tryptophan biosynthetic pathway, catalyzing the ring closure reaction of 1-(o-carboxyphenylamino)-1-deoxyribulose-5-phosphate (CdRP) to indole-3-glycerol phosphate (IGP), accompanied by the...; Region: IGPS; cd00331 114615010468 active site 114615010469 ribulose/triose binding site [chemical binding]; other site 114615010470 phosphate binding site [ion binding]; other site 114615010471 substrate (anthranilate) binding pocket [chemical binding]; other site 114615010472 product (indole) binding pocket [chemical binding]; other site 114615010473 MoaC family, prokaryotic and eukaryotic. Members of this family are involved in molybdenum cofactor (Moco) biosynthesis, an essential cofactor of a diverse group of redox enzymes. MoaC, a small hexameric protein, converts, together with MoaA, a...; Region: MoaC_PE; cd01420 114615010474 trimer interface [polypeptide binding]; other site 114615010475 dimer interface [polypeptide binding]; other site 114615010476 putative active site [active] 114615010477 PAS fold; Region: PAS_7; pfam12860 114615010478 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 114615010479 metal binding site [ion binding]; metal-binding site 114615010480 active site 114615010481 I-site; other site 114615010482 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 114615010483 Periplasmic protease [Cell envelope biogenesis, outer membrane]; Region: Prc; COG0793 114615010484 C-terminal processing peptidase family S41; Region: Peptidase_S41; cl02526 114615010485 PDZ domain of C-terminal processing-, tail-specific-, and tricorn proteases, which function in posttranslational protein processing, maturation, and disassembly or degradation, in Bacteria, Archaea, and plant chloroplasts. May be responsible for...; Region: PDZ_CTP_protease; cd00988 114615010486 protein binding site [polypeptide binding]; other site 114615010487 C-terminal processing peptidase; serine protease family S41; Region: Peptidase_S41_CPP; cd07560 114615010488 Catalytic dyad [active] 114615010489 Family of homologous FMN-dependent alpha-hydroxyacid oxidizing enzymes. This family occurs in both prokaryotes and eukaryotes. Members of this family include flavocytochrome b2 (FCB2), glycolate oxidase (GOX), lactate monooxygenase (LMO), mandelate...; Region: alpha_hydroxyacid_oxid_FMN; cd02809 114615010490 FMN-dependent dehydrogenase; Region: FMN_dh; pfam01070 114615010491 active site 114615010492 substrate binding site [chemical binding]; other site 114615010493 FMN binding site [chemical binding]; other site 114615010494 putative catalytic residues [active] 114615010495 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others...; Region: HAD_like; cl11391 114615010496 TfoX N-terminal domain; Region: TfoX_N; cl01167 114615010497 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 114615010498 Molybdopterin biosynthesis enzyme [Coenzyme metabolism]; Region: MoeA; COG0303 114615010499 MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoeA; cd00887 114615010500 dimer interface [polypeptide binding]; other site 114615010501 putative functional site; other site 114615010502 putative MPT binding site; other site 114615010503 LexA repressor; Validated; Region: PRK00215 114615010504 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 114615010505 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (...; Region: S24_LexA-like; cd06529 114615010506 Catalytic site [active] 114615010507 Competence protein; Region: Competence; cl00471 114615010508 glutaminyl-tRNA synthetase; Provisional; Region: PRK05347 114615010509 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 114615010510 active site 114615010511 HIGH motif; other site 114615010512 nucleotide binding site [chemical binding]; other site 114615010513 catalytic core domain of glutaminyl-tRNA synthetase; Region: GlnRS_core; cd00807 114615010514 KMSKS motif; other site 114615010515 tRNA synthetases class I (E and Q), anti-codon binding domain; Region: tRNA-synt_1c_C; pfam03950 114615010516 glutamyl-tRNA synthetase; Reviewed; Region: gltX; PRK01406 114615010517 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 114615010518 HIGH motif; other site 114615010519 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 114615010520 active site 114615010521 KMSKS motif; other site 114615010522 Escherichia coli (Ec) citrate synthase (CS) GltA_like. CS catalyzes the condensation of acetyl coenzyme A (AcCoA) and oxalacetate (OAA) to form citrate and coenzyme A (CoA), the first step in the citric acid cycle (TCA or Krebs cycle). The overall CS...; Region: EcCS_like; cd06114 114615010523 dimer interface [polypeptide binding]; other site 114615010524 Citrate synthase; Region: Citrate_synt; pfam00285 114615010525 active site 114615010526 citrylCoA binding site [chemical binding]; other site 114615010527 NADH binding [chemical binding]; other site 114615010528 cationic pore residues; other site 114615010529 oxalacetate/citrate binding site [chemical binding]; other site 114615010530 coenzyme A binding site [chemical binding]; other site 114615010531 catalytic triad [active] 114615010532 lipid-A-disaccharide synthase; Reviewed; Region: lpxB; PRK00025 114615010533 ipid-A-disaccharide synthase; Provisional; Region: PRK14089 114615010534 Protein of unknown function (DUF1009); Region: DUF1009; cl09182 114615010535 UDP-N-acetylglucosamine acyltransferase; Provisional; Region: PRK05289 114615010536 UDP-N-acetylglucosamine O-acyltransferase (UDP-GlcNAc acyltransferase): Proteins in this family catalyze the transfer of (R)-3-hydroxymyristic acid from its acyl carrier protein thioester to UDP-GlcNAc. It is the first enzyme in the lipid A...; Region: LbH_UDP-GlcNAc_AT; cd03351 114615010537 active site 114615010538 FabZ is a 17kD beta-hydroxyacyl-acyl carrier protein (ACP) dehydratase that primarily catalyzes the dehydration of beta-hydroxyacyl-ACP to trans-2-acyl-ACP, the third step in the elongation phase of the bacterial/ plastid, type II, fatty-acid...; Region: FabZ; cd01288 114615010539 UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase; Region: lipid_A_lpxD; TIGR01853 114615010540 UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase, LpxD; Region: LpxD; pfam04613 114615010541 UDP-3-O-acyl-glucosamine N-acyltransferase (LpxD): The enzyme catalyzes the transfer of 3-hydroxymyristic acid or 3-hydroxy-arachidic acid, depending on the organism, from the acyl carrier protein (ACP) to UDP-3-O-acyl-glucosamine to produce UDP-2,3-...; Region: LbH_LpxD; cd03352 114615010542 trimer interface [polypeptide binding]; other site 114615010543 active site 114615010544 UDP-GlcNAc binding site [chemical binding]; other site 114615010545 lipid binding site [chemical binding]; lipid-binding site 114615010546 outer membrane protein assembly complex, YaeT protein; Region: OM_YaeT; TIGR03303 114615010547 Surface antigen variable number repeat; Region: Surf_Ag_VNR; cl10520 114615010548 Surface antigen variable number repeat; Region: Surf_Ag_VNR; cl10520 114615010549 Surface antigen variable number repeat; Region: Surf_Ag_VNR; cl10520 114615010550 Surface antigen variable number repeat; Region: Surf_Ag_VNR; cl10520 114615010551 Surface antigen variable number repeat; Region: Surf_Ag_VNR; cl10520 114615010552 Surface antigen; Region: Bac_surface_Ag; cl03097 114615010553 Predicted membrane-associated Zn-dependent proteases 1 [Cell envelope biogenesis, outer membrane]; Region: COG0750 114615010554 RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163 114615010555 active site 114615010556 PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most...; Region: PDZ_metalloprotease; cd00989 114615010557 protein binding site [polypeptide binding]; other site 114615010558 RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163 114615010559 putative substrate binding region [chemical binding]; other site 114615010560 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Provisional; Region: PRK05447 114615010561 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Region: DXP_reductoisom; pfam02670 114615010562 1-deoxy-D-xylulose 5-phosphate reductoisomerase C-terminal; Region: DXP_redisom_C; pfam08436 114615010563 Cytidylyltransferase family; Region: CTP_transf_1; cl00347 114615010564 Undecaprenyl pyrophosphate synthase [Lipid metabolism]; Region: UppS; COG0020 114615010565 Cis (Z)-Isoprenyl Diphosphate Synthases (cis-IPPS); homodimers which catalyze the successive 1'-4 condensation of the isopentenyl diphosphate (IPP) molecule to trans,trans-farnesyl diphosphate (FPP) or to cis,trans-FPP to form long-chain polyprenyl...; Region: CIS_IPPS; cl00230 114615010566 catalytic residue [active] 114615010567 putative FPP diphosphate binding site; other site 114615010568 putative FPP binding hydrophobic cleft; other site 114615010569 dimer interface [polypeptide binding]; other site 114615010570 putative IPP diphosphate binding site; other site 114615010571 Ribosome recycling factor (RRF). Ribosome recycling factor dissociates the posttermination complex, composed of the ribosome, deacylated tRNA, and mRNA, after termination of translation. Thus ribosomes are 'recycled' and ready for another round of...; Region: RRF; cd00520 114615010572 hinge region; other site 114615010573 UMP kinase (UMPK)-Ec, the microbial/chloroplast uridine monophosphate kinase (uridylate kinase) enzyme that catalyzes UMP phosphorylation and plays a key role in pyrimidine nucleotide biosynthesis; regulation of this process is via feed-back control...; Region: AAK_UMPK-PyrH-Ec; cd04254 114615010574 putative nucleotide binding site [chemical binding]; other site 114615010575 uridine monophosphate binding site [chemical binding]; other site 114615010576 homohexameric interface [polypeptide binding]; other site 114615010577 elongation factor Ts; Provisional; Region: tsf; PRK09377 114615010578 Ubiquitin Associated domain. The UBA domain is a commonly occurring sequence motif in some members of the ubiquitination pathway, UV excision repair proteins, and certain protein kinases. Although its specific role is so far unknown, it has been...; Region: UBA; cl00153 114615010579 Elongation factor TS; Region: EF_TS; pfam00889 114615010580 Elongation factor TS; Region: EF_TS; pfam00889 114615010581 30S ribosomal protein S2/unknown domain fusion protein; Provisional; Region: rpsB; PRK12311 114615010582 Ribosomal protein S2 (RPS2), involved in formation of the translation initiation complex, where it might contact the messenger RNA and several components of the ribosome. It has been shown that in Escherichia coli RPS2 is essential for the binding of...; Region: RPS2; cd01425 114615010583 rRNA interaction site [nucleotide binding]; other site 114615010584 S8 interaction site; other site 114615010585 putative laminin-1 binding site; other site 114615010586 Uncharacterized conserved protein [Function unknown]; Region: COG3743 114615010587 Protein of unknown function (DUF2846); Region: DUF2846; pfam11008 114615010588 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 114615010589 phosphopeptide binding site; other site 114615010590 Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic...; Region: Tryp_SPc; cl00149 114615010591 Uncharacterized protein containing caspase domain [General function prediction only]; Region: COG4249 114615010592 Caspase, interleukin-1 beta converting enzyme (ICE) homologues; Cysteine-dependent aspartate-directed proteases that mediate programmed cell death (apoptosis). Caspases are synthesized as inactive zymogens and activated by proteolysis of the peptide...; Region: CASc; cl00042 114615010593 DNA polymerase III subunit alpha; Validated; Region: dnaE; PRK05673 114615010594 DNA polymerase alpha chain like domain; Region: POLIIIAc; smart00481 114615010595 Bacterial DNA polymerase III alpha subunit; Region: DNA_pol3_alpha; pfam07733 114615010596 DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli...; Region: DnaE_OBF; cd04485 114615010597 generic binding surface I; other site 114615010598 generic binding surface II; other site 114615010599 Surface antigen; Region: Surface_Ag_2; cl01155 114615010600 Protein of unknown function (DUF3551); Region: DUF3551; pfam12071 114615010601 Surface antigen; Region: Surface_Ag_2; cl01155 114615010602 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl15258 114615010603 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cd05188 114615010604 NAD(P) binding site [chemical binding]; other site 114615010605 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 114615010606 This family is comprised of MJ0796 ATP-binding cassette, macrolide-specific ABC-type efflux carrier (MacAB), and proteins involved in cell division (FtsE), and release of liporoteins from the cytoplasmic membrane (LolCDE). They are clustered together...; Region: ABC_MJ0796_Lo1CDE_FtsE; cd03255 114615010607 Walker A/P-loop; other site 114615010608 ATP binding site [chemical binding]; other site 114615010609 Q-loop/lid; other site 114615010610 ABC transporter signature motif; other site 114615010611 Walker B; other site 114615010612 D-loop; other site 114615010613 H-loop/switch region; other site 114615010614 LolC/E family; Region: lolCE; TIGR02212 114615010615 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 114615010616 FtsX-like permease family; Region: FtsX; pfam02687 114615010617 prolyl-tRNA synthetase; Provisional; Region: PRK12325 114615010618 Prolyl-tRNA synthetase (ProRS) class II core catalytic domain. ProRS is a homodimer. It is responsible for the attachment of proline to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent formation...; Region: ProRS_core_prok; cd00779 114615010619 dimer interface [polypeptide binding]; other site 114615010620 motif 1; other site 114615010621 active site 114615010622 motif 2; other site 114615010623 motif 3; other site 114615010624 ProRS Prolyl-anticodon binding domain, short version found predominantly in bacteria. ProRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-...; Region: ProRS_anticodon_short; cd00861 114615010625 anticodon binding site; other site 114615010626 Copper resistance protein CopC; Region: CopC; cl01012 114615010627 Copper resistance protein D; Region: CopD; cl00563 114615010628 Reeler-like domain of YcnI and similar proteins; Region: YcnI_like; cd08545 114615010629 Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629 114615010630 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 114615010631 N-terminal plug; other site 114615010632 ligand-binding site [chemical binding]; other site 114615010633 Type 1 glutamine amidotransferase (GATase1)-like domain found in a subgroup of proteins similar to PfpI from Pyrococcus furiosus; Region: GATase1_PfpI_2; cd03139 114615010634 conserved cys residue [active] 114615010635 Protein of unknown function (DUF461); Region: DUF461; cl01071 114615010636 Protein of unknown function (DUF2946); Region: DUF2946; pfam11162 114615010637 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 114615010638 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 114615010639 active site 114615010640 metal binding site [ion binding]; metal-binding site 114615010641 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: RbsB; COG1879 114615010642 Periplasmic sugar-binding domain of uncharacterized ABC-type transport systems; Region: PBP1_ABC_sugar_binding_like_5; cd06313 114615010643 putative ligand binding site [chemical binding]; other site 114615010644 ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129 114615010645 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 114615010646 Walker A/P-loop; other site 114615010647 ATP binding site [chemical binding]; other site 114615010648 Q-loop/lid; other site 114615010649 ABC transporter signature motif; other site 114615010650 Walker B; other site 114615010651 D-loop; other site 114615010652 H-loop/switch region; other site 114615010653 This family represents domain II of the carbohydrate uptake proteins that transport only monosaccharides (Monos). The Carb_Monos family is involved in the uptake of monosaccharides, such as pentoses (such as xylose, arabinose, and ribose) and hexoses (; Region: ABC_Carb_Monos_II; cd03215 114615010654 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 114615010655 TM-ABC transporter signature motif; other site 114615010656 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 114615010657 Phosphotransferase enzyme family; Region: APH; pfam01636 114615010658 Protein of unknown function (DUF1467); Region: DUF1467; cl11569 114615010659 Methylmalonyl-CoA epimerase (MMCE); Region: MMCE; cd07249 114615010660 dimer interface [polypeptide binding]; other site 114615010661 substrate binding site [chemical binding]; other site 114615010662 metal binding site [ion binding]; metal-binding site 114615010663 mRNA degradation ribonucleases J1/J2 (metallo-beta-lactamase superfamily) [Translation, ribosomal structure and biogenesis; Replication, recombination and repair]; Region: COG0595 114615010664 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 114615010665 RNA-metabolising metallo-beta-lactamase; Region: RMMBL; pfam07521 114615010666 Biotin-(acetyl-CoA carboxylase) ligase [Coenzyme metabolism]; Region: BirA; COG0340 114615010667 Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; cl14057 114615010668 Biotin protein ligase C terminal domain; Region: BPL_C; pfam02237 114615010669 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; cl14187 114615010670 NADH dehydrogenase subunit 2; Provisional; Region: ND2; MTH00196 114615010671 NADH:ubiquinone oxidoreductase subunit M; Reviewed; Region: PRK05846 114615010672 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; cl14187 114615010673 NADH:ubiquinone oxidoreductase subunit L; Reviewed; Region: PRK06590 114615010674 NADH-Ubiquinone oxidoreductase (complex I), chain 5 N-terminus; Region: Oxidored_q1_N; pfam00662 114615010675 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; cl14187 114615010676 NADH-ubiquinone/plastoquinone oxidoreductase chain 4L; Region: Oxidored_q2; cl00492 114615010677 NADH:ubiquinone oxidoreductase subunit J; Provisional; Region: PRK06638 114615010678 NADH dehydrogenase subunit J; Provisional; Region: PRK06433; cl14634 114615010679 NADH dehydrogenase subunit I; Provisional; Region: PRK05888 114615010680 4Fe-4S binding domain; Region: Fer4; cl02805 114615010681 4Fe-4S binding domain; Region: Fer4; cl02805 114615010682 NADH dehydrogenase; Region: NADHdh; cl00469 114615010683 NADH dehydrogenase subunit G; Validated; Region: PRK09130 114615010684 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 114615010685 catalytic loop [active] 114615010686 iron binding site [ion binding]; other site 114615010687 NADH-ubiquinone oxidoreductase-G iron-sulfur binding region; Region: NADH-G_4Fe-4S_3; cl11210 114615010688 MopB_Res_Cmplx1_Nad11: The second domain of the Nad11/75-kDa subunit of the NADH-quinone oxidoreductase/respiratory complex I/NADH dehydrogenase-1(NDH-1) of eukaryotes and the Nqo3/G subunit of alphaproteobacteria NDH-1. The NADH-quinone oxidoreductase...; Region: MopB_Res-Cmplx1_Nad11; cd02773 114615010689 Domain of unknown function (DUF1982); Region: DUF1982; pfam09326 114615010690 NADH dehydrogenase I subunit F; Provisional; Region: PRK13596 114615010691 Respiratory-chain NADH dehydrogenase 51 Kd subunit; Region: Complex1_51K; pfam01512 114615010692 SLBB domain; Region: SLBB; pfam10531 114615010693 NADH-ubiquinone oxidoreductase-F iron-sulfur binding region; Region: NADH_4Fe-4S; cl11211 114615010694 NADH dehydrogenase subunit E; Provisional; Region: PRK12373 114615010695 TRX-like [2Fe-2S] Ferredoxin (Fd) family, NADH:ubiquinone oxidoreductase (Nuo) subunit E subfamily; Nuo, also called respiratory chain Complex 1, is the entry point for electrons into the respiratory chains of bacteria and the mitochondria of...; Region: TRX_Fd_NuoE; cd03064 114615010696 putative dimer interface [polypeptide binding]; other site 114615010697 [2Fe-2S] cluster binding site [ion binding]; other site 114615010698 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cl12011 114615010699 Respiratory-chain NADH dehydrogenase, 49 Kd subunit; Region: Complex1_49kDa; cl00417 114615010700 Respiratory-chain NADH dehydrogenase, 30 Kd subunit; Region: Complex1_30kDa; cl00539 114615010701 NADH ubiquinone oxidoreductase, 20 Kd subunit; Region: Oxidored_q6; cl00419 114615010702 NADH-ubiquinone/plastoquinone oxidoreductase, chain 3; Region: Oxidored_q4; cl00535 114615010703 M20 Peptidase T specifically cleaves tripeptides; Region: M20_peptT; cd03892 114615010704 peptidase T; Region: peptidase-T; TIGR01882 114615010705 metal binding site [ion binding]; metal-binding site 114615010706 dimer interface [polypeptide binding]; other site 114615010707 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cd02440 114615010708 S-adenosylmethionine binding site [chemical binding]; other site 114615010709 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 114615010710 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 114615010711 active site 114615010712 metal binding site [ion binding]; metal-binding site 114615010713 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 114615010714 ligand binding site [chemical binding]; other site 114615010715 flexible hinge region; other site 114615010716 ATP-dependent metalloprotease FtsH; Region: FtsH_fam; TIGR01241 114615010717 ATP-dependent Lon protease, bacterial type [Posttranslational modification, protein turnover, chaperones]; Region: Lon; COG0466 114615010718 Found in ATP-dependent protease La (LON); Region: LON; smart00464 114615010719 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes...; Region: AAA; cd00009 114615010720 Walker A motif; other site 114615010721 ATP binding site [chemical binding]; other site 114615010722 Walker B motif; other site 114615010723 arginine finger; other site 114615010724 Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362 114615010725 ATP-dependent protease ATP-binding subunit ClpX; Provisional; Region: clpX; PRK05342 114615010726 ClpX C4-type zinc finger; Region: zf-C4_ClpX; cl05964 114615010727 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes...; Region: AAA; cd00009 114615010728 Walker A motif; other site 114615010729 ATP binding site [chemical binding]; other site 114615010730 Walker B motif; other site 114615010731 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; cl11083 114615010732 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017 114615010733 oligomer interface [polypeptide binding]; other site 114615010734 active site residues [active] 114615010735 trigger factor; Provisional; Region: tig; PRK01490 114615010736 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; cl11587 114615010737 Bacterial trigger factor protein (TF) C-terminus; Region: Trigger_C; pfam05698 114615010738 Putative multicopper oxidases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: SufI; COG2132 114615010739 Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; cl11412 114615010740 L-alanine-DL-glutamate epimerase and related enzymes of enolase superfamily [Cell envelope biogenesis, outer membrane / General function prediction only]; Region: COG4948 114615010741 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl09108 114615010742 metal binding site [ion binding]; metal-binding site 114615010743 substrate binding pocket [chemical binding]; other site 114615010744 YjeF-related protein N-terminus; Region: YjeF_N; cl00318 114615010745 putative carbohydrate kinase; Provisional; Region: PRK10565 114615010746 B.subtilis YXKO protein of unknown function and related proteins. Based on the conservation of the ATP binding site, the substrate binding site and the Mg2+binding site and structural homology this group is a member of the ribokinase-like superfamily; Region: YXKO-related; cd01171 114615010747 putative substrate binding site [chemical binding]; other site 114615010748 putative ATP binding site [chemical binding]; other site 114615010749 NIF3 (NGG1p interacting factor 3); Region: NIF3; cl00412 114615010750 glutamine synthetase; Provisional; Region: glnA; PRK09469 114615010751 Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951 114615010752 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 114615010753 Peptidase C26; Region: Peptidase_C26; pfam07722 114615010754 Subgroup of proteins having the Type 1 glutamine amidotransferase (GATase1) domain; Region: GATase1_2; cd01745 114615010755 catalytic triad [active] 114615010756 Domain of unknown function DUF20; Region: UPF0118; cl00465 114615010757 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 114615010758 M20 Peptidase Aminoacylase 1 subfamily; Region: M20_Acy1_like1; cd05666 114615010759 metal binding site [ion binding]; metal-binding site 114615010760 putative dimer interface [polypeptide binding]; other site 114615010761 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 114615010762 metabolite-proton symporter; Region: 2A0106; TIGR00883 114615010763 putative substrate translocation pore; other site 114615010764 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cl00076 114615010765 Antibiotic biosynthesis monooxygenase; Region: ABM; cl10022 114615010766 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 114615010767 metal binding site [ion binding]; metal-binding site 114615010768 active site 114615010769 I-site; other site 114615010770 Ribosomal protein S9/S16; Region: Ribosomal_S9; cl00334 114615010771 Ribosomal protein L13. Protein L13, a large ribosomal subunit protein, is one of five proteins required for an early folding intermediate of 23S rRNA in the assembly of the large subunit. L13 is situated on the bottom of the large subunit, near the...; Region: Ribosomal_L13; cd00392 114615010772 23S rRNA interface [nucleotide binding]; other site 114615010773 L3 interface [polypeptide binding]; other site 114615010774 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 114615010775 CoenzymeA binding site [chemical binding]; other site 114615010776 subunit interaction site [polypeptide binding]; other site 114615010777 PHB binding site; other site 114615010778 enoyl-CoA hydratase; Validated; Region: PRK08139 114615010779 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase...; Region: crotonase-like; cd06558 114615010780 substrate binding site [chemical binding]; other site 114615010781 oxyanion hole (OAH) forming residues; other site 114615010782 trimer interface [polypeptide binding]; other site 114615010783 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 114615010784 O-acetylhomoserine aminocarboxypropyltransferase; Validated; Region: PRK05994 114615010785 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 114615010786 homodimer interface [polypeptide binding]; other site 114615010787 substrate-cofactor binding pocket; other site 114615010788 pyridoxal 5'-phosphate binding site [chemical binding]; other site 114615010789 catalytic residue [active] 114615010790 cytochrome c oxidase assembly protein; Provisional; Region: PTZ00127 114615010791 Cytochrome oxidase assembly protein; Region: COX15-CtaA; pfam02628 114615010792 Protein of unknown function (DUF2842); Region: DUF2842; pfam11003 114615010793 Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726 114615010794 Polysaccharide deacetylase; Region: Polysacc_deac_1; cl12061 114615010795 Polysaccharide deacetylase; Region: Polysacc_deac_1; cl12061 114615010796 Protein involved in cellulose biosynthesis (CelD) [Cell envelope biogenesis, outer membrane]; Region: COG5653 114615010797 exopolysaccharide transport protein family; Region: eps_transp_fam; TIGR01005 114615010798 Antiactivator of flagellar biosynthesis FleN, an ATPase [Cell motility]; Region: flhG; COG0455 114615010799 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 114615010800 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 114615010801 Undecaprenyl-phosphate glucose phosphotransferase; Region: WcaJ_sugtrans; TIGR03023 114615010802 Bacterial sugar transferase; Region: Bac_transf; cl00939 114615010803 Uncharacterized conserved protein [Function unknown]; Region: COG3268 114615010804 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 114615010805 NAD(P) binding pocket [chemical binding]; other site 114615010806 Uncharacterised ArCR, COG2043; Region: DUF169; cl00894 114615010807 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi...; Region: TPR; cd00189 114615010808 binding surface 114615010809 TPR motif; other site 114615010810 FOG: TPR repeat [General function prediction only]; Region: NrfG; COG0457 114615010811 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi...; Region: TPR; cd00189 114615010812 TPR motif; other site 114615010813 binding surface 114615010814 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi...; Region: TPR; cd00189 114615010815 binding surface 114615010816 TPR motif; other site 114615010817 ADP-heptose:LPS heptosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaF; COG0859 114615010818 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 114615010819 YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259 114615010820 putative active site [active] 114615010821 Acetamidase/Formamidase family; Region: FmdA_AmdA; cl01023 114615010822 Polyphosphate kinase 2 (PPK2); Region: PPK2; cl11971 114615010823 GcrA cell cycle regulator; Region: GcrA; cl11564 114615010824 classical (c) SDRs; Region: SDR_c; cd05233 114615010825 NAD(P) binding site [chemical binding]; other site 114615010826 active site 114615010827 Periplasmic binding domain of the basic membrane lipoprotein Med in Bacillus and its close homologs from other bacteria and Archaea; Region: PBP1_BmpA_Med_like; cd06353 114615010828 putative ligand binding site [chemical binding]; other site 114615010829 Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (; Region: TM_PBP1_transp_TpRbsC_like; cd06580 114615010830 TM-ABC transporter signature motif; other site 114615010831 Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (; Region: TM_PBP1_transp_TpRbsC_like; cd06580 114615010832 TM-ABC transporter signature motif; other site 114615010833 Isochorismatase family; Region: Isochorismatase; pfam00857 114615010834 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cd00431 114615010835 catalytic triad [active] 114615010836 conserved cis-peptide bond; other site 114615010837 ABC-type uncharacterized transport systems, ATPase components [General function prediction only]; Region: COG3845 114615010838 This family represents the domain I of the carbohydrate uptake proteins that transport only monosaccharides (Monos). The Carb_Monos family is involved in the uptake of monosaccharides, such as pentoses (such as xylose, arabinose, and ribose) and...; Region: ABC_Carb_Monos_I; cd03216 114615010839 Walker A/P-loop; other site 114615010840 ATP binding site [chemical binding]; other site 114615010841 Q-loop/lid; other site 114615010842 ABC transporter signature motif; other site 114615010843 Walker B; other site 114615010844 D-loop; other site 114615010845 H-loop/switch region; other site 114615010846 This family represents domain II of the carbohydrate uptake proteins that transport only monosaccharides (Monos). The Carb_Monos family is involved in the uptake of monosaccharides, such as pentoses (such as xylose, arabinose, and ribose) and hexoses (; Region: ABC_Carb_Monos_II; cd03215 114615010847 Streptococcal 67 kDa myosin-cross-reactive antigen like family; Region: Strep_67kDa_ant; cl01939 114615010848 Streptococcal 67 kDa myosin-cross-reactive antigen like family; Region: Strep_67kDa_ant; cl01939 114615010849 Caspase, interleukin-1 beta converting enzyme (ICE) homologues; Cysteine-dependent aspartate-directed proteases that mediate programmed cell death (apoptosis). Caspases are synthesized as inactive zymogens and activated by proteolysis of the peptide...; Region: CASc; cl00042 114615010850 Sporulation related domain; Region: SPOR; cl10051 114615010851 Helix-turn-helix domain; Region: HTH_18; pfam12833 114615010852 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 114615010853 Bacterial transcription activator, effector binding domain; Region: AraC_E_bind; cl01368 114615010854 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cd02440 114615010855 S-adenosylmethionine binding site [chemical binding]; other site 114615010856 RDD family; Region: RDD; cl00746 114615010857 Integral membrane protein DUF95; Region: DUF95; cl00572 114615010858 Uncharacterized conserved protein (some members contain a von Willebrand factor type A (vWA) domain) [General function prediction only]; Region: COG1721 114615010859 Protein of unknown function DUF58; Region: DUF58; pfam01882 114615010860 MoxR-like ATPases [General function prediction only]; Region: COG0714 114615010861 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes...; Region: AAA; cd00009 114615010862 Walker A motif; other site 114615010863 ATP binding site [chemical binding]; other site 114615010864 Walker B motif; other site 114615010865 arginine finger; other site 114615010866 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 114615010867 PIN (PilT N terminus) domain: Superfamily; Region: PIN_SF; cl14812 114615010868 putative transposase OrfB; Reviewed; Region: PHA02517 114615010869 Integrase core domain; Region: rve; cl01316 114615010870 Alkanesulfonate monoxygenase is the monoxygenase of a two-component system that catalyzes the conversion of alkanesulfonates to the corresponding aldehyde and sulfite. Alkanesulfonate monoxygenase (SsuD) has an absolute requirement for reduced flavin...; Region: Alkanesulfonate_monoxygenase; cd01094 114615010871 Luciferase-like monooxygenase; Region: Bac_luciferase; pfam00296 114615010872 active site 114615010873 dimer interface [polypeptide binding]; other site 114615010874 non-prolyl cis peptide bond; other site 114615010875 insertion regions; other site 114615010876 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 114615010877 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cl00427 114615010878 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 114615010879 sulfate ABC transporter, ATP-binding protein; Region: 3a0106s01; TIGR00968 114615010880 NrtD and SsuB are the ATP-binding subunits of the bacterial ABC-type nitrate and sulfonate transport systems, respectively. ABC transporters are a large family of proteins involved in the transport of a wide variety of different compounds, like sugars...; Region: ABC_NrtD_SsuB_transporters; cd03293 114615010881 Walker A/P-loop; other site 114615010882 ATP binding site [chemical binding]; other site 114615010883 Q-loop/lid; other site 114615010884 ABC transporter signature motif; other site 114615010885 Walker B; other site 114615010886 D-loop; other site 114615010887 H-loop/switch region; other site 114615010888 ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components [Inorganic ion transport and metabolism]; Region: TauA; COG0715 114615010889 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and...; Region: PBPb; cd00134 114615010890 substrate binding pocket [chemical binding]; other site 114615010891 membrane-bound complex binding site; other site 114615010892 hinge residues; other site 114615010893 sulfur acquisition oxidoreductase, SfnB family; Region: sulfur_SfnB; TIGR04022 114615010894 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 114615010895 active site 114615010896 Flavin Reductases; Region: FlaRed; cl00801 114615010897 serine O-acetyltransferase; Region: cysE; TIGR01172 114615010898 Serine acetyltransferase (SAT): SAT catalyzes the CoA-dependent acetylation of the side chain hydroxyl group of L-serine to form O-acetylserine, as the first step of a two-step biosynthetic pathway in bacteria and plants leading to the formation of L-...; Region: LbH_SAT; cd03354 114615010899 trimer interface [polypeptide binding]; other site 114615010900 active site 114615010901 substrate binding site [chemical binding]; other site 114615010902 CoA binding site [chemical binding]; other site 114615010903 nitrilotriacetate monoxygenase oxidizes nitrilotriacetate utilizing reduced flavin mononucleotide (FMNH2) and oxygen. The FMNH2 is provided by an NADH:flavin mononucleotide (FMN) oxidorductase that uses NADH to reduce FMN to FMNH2; Region: Nitrilotriacetate_monoxgenase; cd01095 114615010904 FMN-dependent oxidoreductase, nitrilotriacetate monooxygenase family; Region: FMN_nitrolo; TIGR03860 114615010905 active site 114615010906 non-prolyl cis peptide bond; other site 114615010907 Tripartite tricarboxylate transporter family receptor; Region: TctC; cl15260 114615010908 This family contains NADPH-dependent flavin reductase and oxygen-insensitive nitroreductase. These enzymes are homodimeric flavoproteins that contain one FMN per monomer as a cofactor. Flavin reductase catalyzes the reduction of flavin by using NADPH...; Region: NfsA_FRP; cd02146 114615010909 dimer interface [polypeptide binding]; other site 114615010910 FMN binding site [chemical binding]; other site 114615010911 NADPH bind site [chemical binding]; other site 114615010912 Alkanesulfonate monoxygenase is the monoxygenase of a two-component system that catalyzes the conversion of alkanesulfonates to the corresponding aldehyde and sulfite. Alkanesulfonate monoxygenase (SsuD) has an absolute requirement for reduced flavin...; Region: Alkanesulfonate_monoxygenase; cd01094 114615010913 Luciferase-like monooxygenase; Region: Bac_luciferase; pfam00296 114615010914 dimer interface [polypeptide binding]; other site 114615010915 active site 114615010916 non-prolyl cis peptide bond; other site 114615010917 insertion regions; other site 114615010918 Ferredoxin [Energy production and conversion]; Region: COG1146 114615010919 RPB11 and RPB3 subunits of RNA polymerase; Region: RNAP_RPB11_RPB3; cl11409 114615010920 FAD dependent oxidoreductase; Region: DAO; pfam01266 114615010921 Succinate dehydrogenase/fumarate reductase, flavoprotein subunit [Energy production and conversion]; Region: SdhA; COG1053 114615010922 domain; Region: Succ_DH_flav_C; pfam02910 114615010923 hypothetical protein; Provisional; Region: PRK09897 114615010924 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4529 114615010925 Tripartite tricarboxylate transporter family receptor; Region: TctC; cl15260 114615010926 Class II Aldolase and Adducin head (N-terminal) domain. Aldolases are ubiquitous enzymes catalyzing central steps of carbohydrate metabolism. Based on enzymatic mechanisms, this superfamily has been divided into two distinct classes (Class I and II)...; Region: Aldolase_II; cl00214 114615010927 intersubunit interface [polypeptide binding]; other site 114615010928 active site 114615010929 Zn2+ binding site [ion binding]; other site 114615010930 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cl00427 114615010931 DL-methionine transporter ATP-binding subunit; Provisional; Region: metN; PRK11153 114615010932 MetN (also known as YusC) is an ABC-type transporter encoded by metN of the metNPQ operon in Bacillus subtilis that is involved in methionine transport. Other members of this system include the MetP permease and the MetQ substrate binding protein; Region: ABC_MetN_methionine_transporter; cd03258 114615010933 Walker A/P-loop; other site 114615010934 ATP binding site [chemical binding]; other site 114615010935 Q-loop/lid; other site 114615010936 ABC transporter signature motif; other site 114615010937 Walker B; other site 114615010938 D-loop; other site 114615010939 H-loop/switch region; other site 114615010940 NIL domain; Region: NIL; cl09633 114615010941 Probable taurine catabolism dioxygenase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: TauD; COG2175 114615010942 Clavaminic acid synthetase (CAS) -like; CAS is a trifunctional Fe(II)/ 2-oxoglutarate (2OG) oxygenase carrying out three reactions in the biosynthesis of clavulanic acid, an inhibitor of class A serine beta-lactamases. In general, Fe(II)-2OG...; Region: CAS_like; cl00184 114615010943 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3293 114615010944 Predicted acyltransferases [Lipid metabolism]; Region: COG1835 114615010945 Protein required for attachment to host cells; Region: Host_attach; cl02398 114615010946 Protein of unknown function (DUF3775); Region: DUF3775; pfam12616 114615010947 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 114615010948 active site 114615010949 metal binding site [ion binding]; metal-binding site 114615010950 Four helix bundle sensory module for signal transduction; Region: 4HB_MCP_2; pfam12729 114615010951 PAS domain S-box; Region: sensory_box; TIGR00229 114615010952 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 114615010953 putative active site [active] 114615010954 heme pocket [chemical binding]; other site 114615010955 sensory histidine kinase AtoS; Provisional; Region: PRK11360 114615010956 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 114615010957 ATP binding site [chemical binding]; other site 114615010958 Mg2+ binding site [ion binding]; other site 114615010959 G-X-G motif; other site 114615010960 Dihydrodipicolinate synthase family; Region: DHDPS-like; cd00408 114615010961 inhibitor site; inhibition site 114615010962 active site 114615010963 dimer interface [polypeptide binding]; other site 114615010964 catalytic residue [active] 114615010965 (3R)-hydroxyacyl-CoA dehydrogenase-like, classical(c)-like SDRs; Region: hydroxyacyl-CoA-like_DH_SDR_c-like; cd05353 114615010966 homodimer interface [polypeptide binding]; other site 114615010967 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 114615010968 NAD binding site [chemical binding]; other site 114615010969 active site 114615010970 enoyl-CoA hydratase; Region: PLN02864 114615010971 HDE_HSD The R-hydratase-like hot dog fold of the 17-beta-hydroxysteriod dehydrogenase (HSD), and Hydratase-Dehydrogenase-Epimerase (HDE) proteins. Other enzymes with this fold include MaoC dehydratase, and the fatty acid synthase beta subunit; Region: HDE_HSD; cd03448 114615010972 dimer interaction site [polypeptide binding]; other site 114615010973 substrate-binding tunnel; other site 114615010974 active site 114615010975 catalytic site [active] 114615010976 substrate binding site [chemical binding]; other site 114615010977 Rubredoxin-like zinc ribbon domain (DUF35_N); Region: DUF35_N; pfam12172 114615010978 DUF35 OB-fold domain; Region: DUF35; pfam01796 114615010979 acetyl-CoA acetyltransferase; Provisional; Region: PRK08142 114615010980 Thiolase domain associated with sterol carrier protein (SCP)-x isoform and related proteins; SCP-2 has multiple roles in intracellular lipid circulation and metabolism. The N-terminal presequence in the SCP-x isoform represents a peroxisomal 3-ketacyl-; Region: SCP-x_thiolase; cd00829 114615010981 active site 114615010982 indolepyruvate ferredoxin oxidoreductase; Validated; Region: PRK09193 114615010983 Pyrimidine (PYR) binding domain of pyruvate ferredoxin oxidoreductase (PFOR), indolepyruvate ferredoxin oxidoreductase alpha subunit (IOR-alpha), and related proteins; Region: TPP_PYR_PFOR_IOR-alpha_like; cd07034 114615010984 dimer interface [polypeptide binding]; other site 114615010985 PYR/PP interface [polypeptide binding]; other site 114615010986 TPP binding site [chemical binding]; other site 114615010987 substrate binding site [chemical binding]; other site 114615010988 Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin...; Region: TPP_enzymes; cl01629 114615010989 TPP-binding site [chemical binding]; other site 114615010990 Pyruvate ferredoxin/flavodoxin oxidoreductase; Region: POR; cl00546 114615010991 Predicted membrane protein [Function unknown]; Region: COG2860 114615010992 UPF0126 domain; Region: UPF0126; pfam03458 114615010993 UPF0126 domain; Region: UPF0126; pfam03458 114615010994 Photosystem P840 reaction-centre cytochrome c-551; Region: Cytochrome-c551; pfam10643 114615010995 Members of the ICL/PEPM enzyme family catalyze either P-C or C-C bond formation/cleavage. Known members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate hydrolase (OAH), isocitrate...; Region: ICL_PEPM; cd00377 114615010996 tetramer interface [polypeptide binding]; other site 114615010997 active site 114615010998 Mg2+/Mn2+ binding site [ion binding]; other site 114615010999 NIPSNAP; Region: NIPSNAP; pfam07978 114615011000 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 114615011001 dimerization interface [polypeptide binding]; other site 114615011002 putative DNA binding site [nucleotide binding]; other site 114615011003 putative Zn2+ binding site [ion binding]; other site 114615011004 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 114615011005 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 114615011006 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 114615011007 EthD protein; Region: EthD; cl06234 114615011008 methylmalonyl-CoA decarboxylase alpha subunit; Region: mmdA; TIGR01117 114615011009 Acetyl co-enzyme A carboxylase carboxyltransferase alpha subunit; Region: ACCA; cl00513 114615011010 Acetyl co-enzyme A carboxylase carboxyltransferase alpha subunit; Region: ACCA; cl00513 114615011011 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 114615011012 RNA polymerase sigma-70 factor, TIGR02960 family; Region: SigX5 114615011013 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl15258 114615011014 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: FabG; COG1028 114615011015 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 114615011016 peptidase T-like protein; Region: PepT-like; TIGR01883 114615011017 M28, and M42; Region: Zinc_peptidase_like; cl14876 114615011018 metal binding site [ion binding]; metal-binding site 114615011019 RbsD / FucU transport protein family; Region: RbsD_FucU; cl00809 114615011020 Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cl00264 114615011021 Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285 114615011022 nucleoside/Zn binding site; other site 114615011023 dimer interface [polypeptide binding]; other site 114615011024 catalytic motif [active] 114615011025 Transcriptional activator of acetoin/glycerol metabolism [Secondary metabolites biosynthesis, transport, and catabolism / Transcription]; Region: AcoR; COG3284 114615011026 GAF domain; Region: GAF; cl00853 114615011027 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes...; Region: AAA; cd00009 114615011028 Walker A motif; other site 114615011029 ATP binding site [chemical binding]; other site 114615011030 Walker B motif; other site 114615011031 arginine finger; other site 114615011032 Bacterial regulatory protein, Fis family; Region: HTH_8; cl01091 114615011033 chaperonin GroEL; Reviewed; Region: groEL; PRK12849 114615011034 GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344 114615011035 ring oligomerisation interface [polypeptide binding]; other site 114615011036 ATP/Mg binding site [chemical binding]; other site 114615011037 stacking interactions; other site 114615011038 hinge regions; other site 114615011039 Domain of unknown function DUF59; Region: DUF59; cl00941 114615011040 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have...; Region: metallo-dependent_hydrolases; cd01292 114615011041 active site 114615011042 MmoB/DmpM family; Region: MmoB_DmpM; pfam02406 114615011043 Aromatic and Alkene Monooxygenase Hydroxylase, subunit B, ferritin-like diiron-binding domain; Region: AAMH_B; cd01058 114615011044 dimerization interface [polypeptide binding]; other site 114615011045 CDP-6-deoxy-delta-3,4-glucoseen reductase; Validated; Region: PRK07609 114615011046 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 114615011047 catalytic loop [active] 114615011048 iron binding site [ion binding]; other site 114615011049 The oxygenase reductase FAD/NADH binding domain acts as part of the multi-component bacterial oxygenases which oxidize hydrocarbons. These flavoprotein monooxygenases use molecular oxygen as a substrate and require reduced FAD. One atom of oxygen is...; Region: monooxygenase_like; cd06212 114615011050 FAD binding pocket [chemical binding]; other site 114615011051 FAD binding motif [chemical binding]; other site 114615011052 phosphate binding motif [ion binding]; other site 114615011053 beta-alpha-beta structure motif; other site 114615011054 NAD binding pocket [chemical binding]; other site 114615011055 Aromatic and Alkene Monooxygenase Hydroxylase, subunit A, ferritin-like diiron-binding domain; Region: AAMH_A; cd01057 114615011056 dimerization interface [polypeptide binding]; other site 114615011057 putative path to active site cavity [active] 114615011058 diiron center [ion binding]; other site 114615011059 Zn-dependent alcohol dehydrogenases [General function prediction only]; Region: AdhP; COG1064 114615011060 D-arabinose dehydrogenase; Region: arabinose_DH_like; cd05284 114615011061 NAD binding site [chemical binding]; other site 114615011062 substrate binding site [chemical binding]; other site 114615011063 catalytic Zn binding site [ion binding]; other site 114615011064 structural Zn binding site [ion binding]; other site 114615011065 Transcriptional activator of acetoin/glycerol metabolism [Secondary metabolites biosynthesis, transport, and catabolism / Transcription]; Region: AcoR; COG3284 114615011066 GAF domain; Region: GAF; cl00853 114615011067 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459 114615011068 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes...; Region: AAA; cd00009 114615011069 Walker A motif; other site 114615011070 ATP binding site [chemical binding]; other site 114615011071 Walker B motif; other site 114615011072 arginine finger; other site 114615011073 Bacterial regulatory protein, Fis family; Region: HTH_8; cl01091 114615011074 SseB protein; Region: SseB; cl06279 114615011075 Domain of unknown function (DUF1989); Region: DUF1989; cl01474 114615011076 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and...; Region: PBPb; cd00134 114615011077 substrate binding pocket [chemical binding]; other site 114615011078 membrane-bound complex binding site; other site 114615011079 hinge residues; other site 114615011080 Alkanesulfonate monoxygenase is the monoxygenase of a two-component system that catalyzes the conversion of alkanesulfonates to the corresponding aldehyde and sulfite. Alkanesulfonate monoxygenase (SsuD) has an absolute requirement for reduced flavin...; Region: Alkanesulfonate_monoxygenase; cd01094 114615011081 active site 114615011082 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases [Energy production and conversion]; Region: COG2141 114615011083 dimer interface [polypeptide binding]; other site 114615011084 non-prolyl cis peptide bond; other site 114615011085 insertion regions; other site 114615011086 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 114615011087 Acyl-CoA dehydrogenase, N-terminal domain; Region: Acyl-CoA_dh_N; pfam02771 114615011088 Acyl-CoA dehydrogenase; Region: ACAD; cd00567 114615011089 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 114615011090 NrtD and SsuB are the ATP-binding subunits of the bacterial ABC-type nitrate and sulfonate transport systems, respectively. ABC transporters are a large family of proteins involved in the transport of a wide variety of different compounds, like sugars...; Region: ABC_NrtD_SsuB_transporters; cd03293 114615011091 Walker A/P-loop; other site 114615011092 ATP binding site [chemical binding]; other site 114615011093 Q-loop/lid; other site 114615011094 ABC transporter signature motif; other site 114615011095 Walker B; other site 114615011096 D-loop; other site 114615011097 H-loop/switch region; other site 114615011098 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 114615011099 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261 114615011100 dimer interface [polypeptide binding]; other site 114615011101 conserved gate region; other site 114615011102 putative PBP binding loops; other site 114615011103 ABC-ATPase subunit interface; other site 114615011104 ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components [Inorganic ion transport and metabolism]; Region: TauA; COG0715 114615011105 Tripartite tricarboxylate transporter family receptor; Region: TctC; cl15260 114615011106 Low-density lipoprotein receptor repeat class B; Region: Ldl_recept_b; cl10508 114615011107 alpha-L-glutamate ligases, RimK family; Region: rimK_fam; TIGR00768 114615011108 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; cl03087 114615011109 Bacterial Ig-like domain (group 2); Region: Big_2; cl02708 114615011110 Uncharacterized protein conserved in bacteria (DUF2313); Region: DUF2313; cl01542 114615011111 Baseplate J-like protein; Region: Baseplate_J; cl01294 114615011112 Baseplate J-like protein; Region: Baseplate_J; cl01294 114615011113 Baseplate J-like protein; Region: Baseplate_J; cl01294 114615011114 Baseplate J-like protein; Region: Baseplate_J; cl01294 114615011115 Gene 25-like lysozyme; Region: GPW_gp25; cl01403 114615011116 Phage-related baseplate assembly protein; Region: Phage_base_V; cl11432 114615011117 Uncharacterized protein conserved in bacteria [Function unknown]; Region: VgrG; COG3501 114615011118 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes...; Region: AAA; cd00009 114615011119 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 114615011120 Walker A motif; other site 114615011121 ATP binding site [chemical binding]; other site 114615011122 Walker B motif; other site 114615011123 arginine finger; other site 114615011124 DNA polymerase III subunits gamma and tau; Provisional; Region: PRK12323 114615011125 T4-like virus tail tube protein gp19; Region: Phage_T4_gp19; cl12125 114615011126 Phage tail sheath protein; Region: Phage_sheath_1; cl01389 114615011127 Phage tail sheath protein; Region: Phage_sheath_1; cl01389 114615011128 Alpha-glucosidases, family 31 of glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: COG1501 114615011129 Glycosyl hydrolase family 31 (GH31) domain of a bacterial protein family represented by Escherichia coli protein Aec37. The gene encoding Aec37 (aec-37) is located within a genomic island (AGI-3) isolated from the extraintestinal avian pathogenic...; Region: GH31_glycosidase_Aec37; cd06599 114615011130 putative active site [active] 114615011131 putative catalytic site [active] 114615011132 glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650 114615011133 The N-terminal ATPase domain of the maltose transporter, MalK. ATP binding cassette (ABC) proteins function from bacteria to human, mediating the translocation of substances into and out of cells or organelles. ABC transporters contain two...; Region: ABC_MalK_N; cd03301 114615011134 Walker A/P-loop; other site 114615011135 ATP binding site [chemical binding]; other site 114615011136 Q-loop/lid; other site 114615011137 ABC transporter signature motif; other site 114615011138 Walker B; other site 114615011139 D-loop; other site 114615011140 H-loop/switch region; other site 114615011141 TOBE domain; Region: TOBE_2; cl01440 114615011142 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261 114615011143 dimer interface [polypeptide binding]; other site 114615011144 conserved gate region; other site 114615011145 putative PBP binding loops; other site 114615011146 ABC-ATPase subunit interface; other site 114615011147 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 114615011148 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261 114615011149 dimer interface [polypeptide binding]; other site 114615011150 conserved gate region; other site 114615011151 putative PBP binding loops; other site 114615011152 ABC-ATPase subunit interface; other site 114615011153 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 114615011154 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 114615011155 catabolite control protein A; Region: ccpA; TIGR01481 114615011156 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 114615011157 DNA binding site [nucleotide binding] 114615011158 domain linker motif; other site 114615011159 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 114615011160 dimerization interface [polypeptide binding]; other site 114615011161 ligand binding site [chemical binding]; other site 114615011162 VRR-NUC domain; Region: VRR_NUC; cl08494 114615011163 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 114615011164 active site 114615011165 substrate binding site [chemical binding]; other site 114615011166 catalytic site [active] 114615011167 GGCT-like domains, also called AIG2-like family. Gamma-glutamyl cyclotransferase (GGCT) catalyzes the formation of pyroglutamic acid (5-oxoproline) from dipeptides containing gamma-glutamyl, and is a dimeric protein. In Homo sapiens, the protein is...; Region: GGCT_like; cl11426 114615011168 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_7; cd08512 114615011169 Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496 114615011170 putative amidase; Provisional; Region: PRK06169 114615011171 GGCT-like domains, also called AIG2-like family. Gamma-glutamyl cyclotransferase (GGCT) catalyzes the formation of pyroglutamic acid (5-oxoproline) from dipeptides containing gamma-glutamyl, and is a dimeric protein. In Homo sapiens, the protein is...; Region: GGCT_like; cl11426 114615011172 ABC-type oligopeptide transport system, ATPase component [Amino acid transport and metabolism]; Region: AppF; COG4608 114615011173 The ABC transporter subfamily specific for the transport of dipeptides, oligopeptides (OppD), and nickel (NikDE). The NikABCDE system of E. coli belongs to this family and is composed of the periplasmic binding protein NikA, two integral membrane...; Region: ABC_NikE_OppD_transporters; cd03257 114615011174 Walker A/P-loop; other site 114615011175 ATP binding site [chemical binding]; other site 114615011176 Q-loop/lid; other site 114615011177 ABC transporter signature motif; other site 114615011178 Walker B; other site 114615011179 D-loop; other site 114615011180 H-loop/switch region; other site 114615011181 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 114615011182 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 114615011183 The ABC transporter subfamily specific for the transport of dipeptides, oligopeptides (OppD), and nickel (NikDE). The NikABCDE system of E. coli belongs to this family and is composed of the periplasmic binding protein NikA, two integral membrane...; Region: ABC_NikE_OppD_transporters; cd03257 114615011184 Walker A/P-loop; other site 114615011185 ATP binding site [chemical binding]; other site 114615011186 Q-loop/lid; other site 114615011187 ABC transporter signature motif; other site 114615011188 Walker B; other site 114615011189 D-loop; other site 114615011190 H-loop/switch region; other site 114615011191 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 114615011192 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261 114615011193 dimer interface [polypeptide binding]; other site 114615011194 conserved gate region; other site 114615011195 putative PBP binding loops; other site 114615011196 ABC-ATPase subunit interface; other site 114615011197 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 114615011198 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cl00427 114615011199 DNA-binding transcriptional repressor PuuR; Provisional; Region: PRK09943 114615011200 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 114615011201 non-specific DNA binding site [nucleotide binding]; other site 114615011202 salt bridge; other site 114615011203 sequence-specific DNA binding site [nucleotide binding]; other site 114615011204 Cupin domain; Region: Cupin_2; cl09118 114615011205 Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154 114615011206 GGCT-like domains, also called AIG2-like family. Gamma-glutamyl cyclotransferase (GGCT) catalyzes the formation of pyroglutamic acid (5-oxoproline) from dipeptides containing gamma-glutamyl, and is a dimeric protein. In Homo sapiens, the protein is...; Region: GGCT_like; cl11426 114615011207 Type 1 glutamine amidotransferase (GATase1)-like domain found in proteins similar to Escherichia coli Hsp31 protein; Region: GATase1_Hsp31_like; cd03141 114615011208 potential catalytic triad [active] 114615011209 conserved cys residue [active] 114615011210 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 114615011211 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 114615011212 Transcriptional regulator containing an amidase domain and an AraC-type DNA-binding HTH domain [Transcription]; Region: COG4977 114615011213 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 114615011214 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 114615011215 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 114615011216 The (Largely Gram-negative Bacterial) Hydrophobe/Amphiphile Efflux-1 (HAE1) Family; Region: 2A0602; TIGR00915 114615011217 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 114615011218 Helix-Turn-Helix DNA binding domain of putative MlrA-like transcription regulators; Region: HTH_MlrA-like_sg2; cd04765 114615011219 DNA binding residues [nucleotide binding] 114615011220 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and higher-...; Region: HU_IHF; cd00591 114615011221 IHF dimer interface [polypeptide binding]; other site 114615011222 IHF - DNA interface [nucleotide binding]; other site 114615011223 3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK09352 114615011224 Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830 114615011225 dimer interface [polypeptide binding]; other site 114615011226 active site 114615011227 CoA binding pocket [chemical binding]; other site 114615011228 Phosphate acetyl/butaryl transferase; Region: PTA_PTB; cl00390 114615011229 Uncharacterized ACR, COG1399; Region: DUF177; cl00616 114615011230 Ubiquinol-cytochrome C chaperone; Region: Ubiq_cyt_C_chap; cl12045 114615011231 SmpA / OmlA family; Region: SmpA_OmlA; cl01095 114615011232 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5330 114615011233 Uncharacterized protein conserved in bacteria (DUF2336); Region: DUF2336; pfam10098 114615011234 Inorganic pyrophosphatase [Energy production and conversion]; Region: OVP1; cl11452 114615011235 membrane-bound proton-translocating pyrophosphatase; Validated; Region: hppA; PRK00733 114615011236 thiamine monophosphate kinase; Provisional; Region: PRK05731 114615011237 ThiL (Thiamine-monophosphate kinase) plays a dual role in de novo biosynthesis and in salvage of exogenous thiamine. Thiamine salvage occurs in two steps, with thiamine kinase catalyzing the formation of thiamine phosphate, and ThiL catalyzing the...; Region: ThiL; cd02194 114615011238 ATP binding site [chemical binding]; other site 114615011239 dimerization interface [polypeptide binding]; other site 114615011240 RNA binding domain of NusB (N protein-Utilization Substance B) and Sun (also known as RrmB or Fmu) proteins. This family includes two orthologous groups exemplified by the transcription termination factor NusB and the N-terminal domain of the rRNA-...; Region: NusB_Sun; cl00223 114615011241 putative RNA binding site [nucleotide binding]; other site 114615011242 lumazine synthase (6,7-dimethyl-8-ribityllumazine synthase, LS), catalyzes the penultimate step in the biosynthesis of riboflavin (vitamin B2); type-I; Region: Lumazine_synthase-I; cd09209 114615011243 homopentamer interface [polypeptide binding]; other site 114615011244 active site 114615011245 riboflavin synthase subunit alpha; Provisional; Region: PRK09289 114615011246 Lumazine binding domain; Region: Lum_binding; pfam00677 114615011247 Lumazine binding domain; Region: Lum_binding; pfam00677 114615011248 riboflavin biosynthesis protein RibD; Region: eubact_ribD; TIGR00326 114615011249 Riboflavin-specific deaminase. Riboflavin biosynthesis protein RibD (Diaminohydroxyphosphoribosylaminopyrimidine deaminase) catalyzes the deamination of 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate, which is an intermediate step in the...; Region: Riboflavin_deaminase-reductase; cd01284 114615011250 catalytic motif [active] 114615011251 Zn binding site [ion binding]; other site 114615011252 Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5,10-...; Region: DHFR; cl00161 114615011253 transcriptional regulator NrdR; Validated; Region: nrdR; PRK00464 114615011254 ATP cone domain; Region: ATP-cone; pfam03477 114615011255 serine hydroxymethyltransferase; Reviewed; Region: glyA; PRK00011 114615011256 Serine-glycine hydroxymethyltransferase (SHMT). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). SHMT carries out interconversion of serine and glycine; it catalyzes the transfer of...; Region: SHMT; cd00378 114615011257 dimer interface [polypeptide binding]; other site 114615011258 glycine-pyridoxal phosphate binding site [chemical binding]; other site 114615011259 active site 114615011260 folate binding site [chemical binding]; other site 114615011261 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 114615011262 Porphobilinogen synthase (PBGS), which is also called delta-aminolevulinic acid dehydratase (ALAD), catalyzes the condensation of two 5-aminolevulinic acid (ALA) molecules to form the pyrrole porphobilinogen (PBG), which is the second step in the...; Region: ALAD_PBGS_aspartate_rich; cd04823 114615011263 dimer interface [polypeptide binding]; other site 114615011264 allosteric magnesium binding site [ion binding]; other site 114615011265 active site 114615011266 aspartate-rich active site metal binding site; other site 114615011267 Schiff base residues; other site 114615011268 RDD family; Region: RDD; cl00746 114615011269 arginyl-tRNA-protein transferase; Provisional; Region: PRK01305 114615011270 Arginine-tRNA-protein transferase, N terminus; Region: ATE_N; pfam04376 114615011271 Arginine-tRNA-protein transferase, C terminus; Region: ATE_C; pfam04377 114615011272 Natural resistance-associated macrophage protein; Region: Nramp; cl00836 114615011273 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cl12011 114615011274 Bacterial protein of unknown function (DUF894); Region: DUF894; pfam05977 114615011275 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cl12011 114615011276 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 114615011277 Ligand Binding Site [chemical binding]; other site 114615011278 cyclase homology domain; Region: CHD; cd07302 114615011279 nucleotidyl binding site; other site 114615011280 metal binding site [ion binding]; metal-binding site 114615011281 dimer interface [polypeptide binding]; other site 114615011282 Arsenate Reductase (ArsC) family, ArsC subfamily; arsenic reductases similar to that encoded by arsC on the R733 plasmid of Escherichia coli. E. coli ArsC catalyzes the reduction of arsenate [As(V)] to arsenite [As(III)], the first step in the...; Region: ArsC_ArsC; cd03034 114615011283 catalytic residues [active] 114615011284 GlpE sulfurtransferase (ST) and homologs are members of the Rhodanese Homology Domain superfamily. Unlike other rhodanese sulfurtransferases, GlpE is a single domain protein but indications are that it functions as a dimer. The active site contains a...; Region: GlpE_ST; cd01444 114615011285 active site residue [active] 114615011286 Chromate resistance exported protein; Region: Chrome_Resist; cl01744 114615011287 Chromate transporter; Region: Chromate_transp; pfam02417 114615011288 Chromate transporter; Region: Chromate_transp; pfam02417 114615011289 Cation efflux family; Region: Cation_efflux; cl00316 114615011290 DNA topoisomerase IV subunit A; Validated; Region: PRK05561 114615011291 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes in...; Region: TOP4c; cd00187 114615011292 CAP-like domain; other site 114615011293 Active site [active] 114615011294 primary dimer interface [polypeptide binding]; other site 114615011295 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 114615011296 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 114615011297 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 114615011298 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 114615011299 C-terminal, alpha helical domain of the Glutathione S-transferase family; Region: GST_C_family; cl02776 114615011300 dimer interface [polypeptide binding]; other site 114615011301 substrate binding pocket (H-site) [chemical binding]; other site 114615011302 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 114615011303 3-ketosteroid-delta-1-dehydrogenase; Provisional; Region: PRK12837 114615011304 hypothetical protein; Validated; Region: PRK07586 114615011305 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 114615011306 PYR/PP interface [polypeptide binding]; other site 114615011307 dimer interface [polypeptide binding]; other site 114615011308 TPP binding site [chemical binding]; other site 114615011309 TPP-binding module; composed of proteins similar to Pseudomonas putida benzoylformate decarboxylase (BFDC). P. putida BFDC plays a role in the mandelate pathway, catalyzing the conversion of benzoylformate to benzaldehyde and carbon dioxide. This...; Region: TPP_BFDC; cd02002 114615011310 TPP-binding site [chemical binding]; other site 114615011311 dimer interface [polypeptide binding]; other site 114615011312 Transcriptional regulator [Transcription]; Region: LysR; COG0583 114615011313 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 114615011314 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 114615011315 dimerization interface [polypeptide binding]; other site 114615011316 ACT domain; Region: ACT_3; cl01447 114615011317 Predicted glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: ECM4; COG0435 114615011318 C-terminal, alpha helical domain of Class Omega-like Glutathione S-transferases; Region: GST_C_Omega_like; cd03190 114615011319 putative dimer interface [polypeptide binding]; other site 114615011320 N-terminal domain interface [polypeptide binding]; other site 114615011321 putative substrate binding pocket (H-site) [chemical binding]; other site 114615011322 DNA repair protein RecO; Reviewed; Region: recO; PRK00085 114615011323 Recombination protein O N terminal; Region: RecO_N; pfam11967 114615011324 Recombination protein O C terminal; Region: RecO_C; pfam02565 114615011325 GTPase Era; Reviewed; Region: era; PRK00089 114615011326 Era subfamily. Era (E. coli Ras-like protein) is a multifunctional GTPase found in all bacteria except some eubacteria. It binds to the 16S ribosomal RNA (rRNA) of the 30S subunit and appears to play a role in the assembly of the 30S subunit...; Region: Era; cd04163 114615011327 G1 box; other site 114615011328 GTP/Mg2+ binding site [chemical binding]; other site 114615011329 Switch I region; other site 114615011330 G2 box; other site 114615011331 Switch II region; other site 114615011332 G3 box; other site 114615011333 G4 box; other site 114615011334 G5 box; other site 114615011335 K homology RNA-binding domain, type I. KH binds single-stranded RNA or DNA. It is found in a wide variety of proteins including ribosomal proteins, transcription factors and post-transcriptional modifiers of mRNA. There are two different KH domains...; Region: KH-I; cl00098 114615011336 2-oxoglutarate dehydrogenase, E2 component, dihydrolipoamide succinyltransferase; Region: SucB_Actino; TIGR02927 114615011337 ribonuclease III, bacterial; Region: RNaseIII; TIGR02191 114615011338 RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in post-...; Region: RIBOc; cd00593 114615011339 dimerization interface [polypeptide binding]; other site 114615011340 active site 114615011341 metal binding site [ion binding]; metal-binding site 114615011342 Double-stranded RNA binding motif. Binding is not sequence specific but is highly specific for double stranded RNA. Found in a variety of proteins including dsRNA dependent protein kinase PKR, RNA helicases, Drosophila staufen protein, E. coli RNase...; Region: DSRM; cd00048 114615011343 dsRNA binding site [nucleotide binding]; other site 114615011344 signal peptidase I; Provisional; Region: PRK10861 114615011345 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 114615011346 Catalytic site [active] 114615011347 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 114615011348 4'-phosphopantetheinyl transferase superfamily; Region: ACPS; cl00500 114615011349 Pyridoxine 5'-phosphate (PNP) synthase domain; pyridoxal 5'-phosphate is the active form of vitamin B6 that acts as an essential, ubiquitous coenzyme in amino acid metabolism. In bacteria, formation of pyridoxine 5'-phosphate is a step in the...; Region: PNPsynthase; cd00003 114615011350 active site 114615011351 hydrophilic channel; other site 114615011352 dimerization interface [polypeptide binding]; other site 114615011353 catalytic residues [active] 114615011354 active site lid [active] 114615011355 Guanosine polyphosphate pyrophosphohydrolases/synthetases [Signal transduction mechanisms / Transcription]; Region: SpoT; COG0317 114615011356 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cl00076 114615011357 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 114615011358 synthetase active site [active] 114615011359 NTP binding site [chemical binding]; other site 114615011360 metal binding site [ion binding]; metal-binding site 114615011361 TGS_RelA_SpoT: The RelA (SpoT) protein, also referred to as ppGpp hydrolase/synthetase, is a ribosome-associated protein that is activated during amino acid starvation and thought to mediate the stringent response. RelA contains a TGS domain, named...; Region: TGS_RelA_SpoT; cd01668 114615011362 ACT domain found C-terminal of the RelA/SpoT domains; Region: ACT_RelA-SpoT; cd04876 114615011363 RNA polymerase Rpb6; Region: RNA_pol_Rpb6; cl14651 114615011364 Uncharacterized conserved protein [Function unknown]; Region: COG1432 114615011365 LabA_like proteins. A well conserved group of bacterial proteins with no defined function. LabA, a member from Synechococcus elongatus PCC 7942, has been shown to play a role in cyanobacterial circadian timing. It is required for negative feedback...; Region: LabA_like; cd06167 114615011366 putative metal binding site [ion binding]; other site 114615011367 Family-5 Uracil-DNA glycosylases (UDG), found in thermophilic organisms; Region: UDG_F5_TTUDGB_like; cd10031 114615011368 Fe-S cluster binding site [ion binding]; other site 114615011369 DNA binding site [nucleotide binding] 114615011370 active site 114615011371 Peroxiredoxin (PRX) family, Bacterioferritin comigratory protein (BCP) subfamily; composed of thioredoxin-dependent thiol peroxidases, widely expressed in pathogenic bacteria, that protect cells against toxicity from reactive oxygen species by...; Region: PRX_BCP; cd03017 114615011372 catalytic triad [active] 114615011373 Small protein B (SmpB) is a component of the trans-translation system in prokaryotes for releasing stalled ribosome from damaged messenger RNAs; Region: SmpB; cd09294 114615011374 SmpB-tmRNA interface; other site 114615011375 Large-conductance mechanosensitive channel, MscL; Region: MscL; cl00860 114615011376 Dihydrodipicolinate synthase (DHDPS); Region: DHDPS; cd00950 114615011377 dihydrodipicolinate synthase; Region: dapA; TIGR00674 114615011378 dimer interface [polypeptide binding]; other site 114615011379 active site 114615011380 catalytic residue [active] 114615011381 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic 'goose-type' lysozymes (GEWL). LTs catalyze...; Region: LT_GEWL; cd00254 114615011382 N-acetyl-D-glucosamine binding site [chemical binding]; other site 114615011383 catalytic residue [active] 114615011384 Porin subfamily; Region: Porin_2; pfam02530 114615011385 Porin subfamily; Region: Porin_2; pfam02530 114615011386 aspartyl/glutamyl-tRNA amidotransferase subunit B; Validated; Region: gatB; PRK05477 114615011387 GatB/GatE catalytic domain; Region: GatB_N; pfam02934 114615011388 GatB domain; Region: GatB_Yqey; cl11497 114615011389 Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154 114615011390 GGCT-like domains, also called AIG2-like family. Gamma-glutamyl cyclotransferase (GGCT) catalyzes the formation of pyroglutamic acid (5-oxoproline) from dipeptides containing gamma-glutamyl, and is a dimeric protein. In Homo sapiens, the protein is...; Region: GGCT_like; cl11426 114615011391 Glu-tRNAGln amidotransferase C subunit; Region: Glu-tRNAGln; cl00495 114615011392 Dioxygenases related to 2-nitropropane dioxygenase [General function prediction only]; Region: COG2070 114615011393 2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin...; Region: NPD_like; cd04730 114615011394 FMN binding site [chemical binding]; other site 114615011395 substrate binding site [chemical binding]; other site 114615011396 putative catalytic residue [active] 114615011397 Nitronate monooxygenase; Region: NMO; pfam03060 114615011398 2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin...; Region: NPD_like; cd04730 114615011399 FMN binding site [chemical binding]; other site 114615011400 substrate binding site [chemical binding]; other site 114615011401 putative catalytic residue [active] 114615011402 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 114615011403 The C-terminal substrate binding domain of LysR-type transcriptional regulators, YofA and SoxR, contains the type 2 periplasmic binding fold; Region: PBP2_YofA_SoxR_like; cd08442 114615011404 putative dimerization interface [polypeptide binding]; other site 114615011405 Putative cyclase; Region: Cyclase; cl00814 114615011406 heme ABC exporter, ATP-binding protein CcmA; Region: ccmA; TIGR01189 114615011407 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 114615011408 Walker A/P-loop; other site 114615011409 ATP binding site [chemical binding]; other site 114615011410 Q-loop/lid; other site 114615011411 ABC transporter signature motif; other site 114615011412 Walker B; other site 114615011413 D-loop; other site 114615011414 H-loop/switch region; other site 114615011415 ABCF_EF-3 Elongation factor 3 (EF-3) is a cytosolic protein required by fungal ribosomes for in vitro protein synthesis and for in vivo growth. EF-3 stimulates the binding of the EF-1: GTP: aa-tRNA ternary complex to the ribosomal A site by...; Region: ABCF_EF-3; cd03221 114615011416 cobalt transport protein ATP-binding subunit; Region: cbiO; TIGR01166 114615011417 Holliday junction resolvases (HJRs) are endonucleases that specifically resolve Holliday junction DNA intermediates during homologous recombination. HJR's occur in archaea, bacteria, and in the mitochondria of certain fungi, however this CD includes...; Region: RuvC_resolvase; cl00243 114615011418 Membrane transport protein; Region: Mem_trans; cl09117 114615011419 CAAX amino terminal protease self- immunity; Region: Abi; cl00558 114615011420 CAAX amino terminal protease self- immunity; Region: Abi; cl00558 114615011421 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 114615011422 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 114615011423 active site 114615011424 aspartate carbamoyltransferase catalytic subunit; Provisional; Region: pyrB; PRK00856 114615011425 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 114615011426 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 114615011427 dihydroorotase; Validated; Region: PRK09059 114615011428 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have...; Region: metallo-dependent_hydrolases; cl00281 114615011429 Dihydroorotase (DHOase), subgroup IIa; DHOases catalyze the reversible interconversion of carbamoyl aspartate to dihydroorotate, a key reaction in pyrimidine biosynthesis. This subgroup also contains proteins that lack the active site, like unc-33, a C...; Region: DHOase_IIa; cd01317 114615011430 active site 114615011431 Domain of unknown function (DUF205); Region: DUF205; cl00410 114615011432 Patatins and Phospholipases; Region: Patatin_and_cPLA2; cl11396 114615011433 active site 114615011434 nucleophile elbow; other site 114615011435 Predicted Rossmann fold nucleotide-binding protein involved in DNA uptake [DNA replication, recombination, and repair / Intracellular trafficking and secretion]; Region: Smf; COG0758 114615011436 DNA recombination-mediator protein A; Region: DNA_processg_A; cl00695 114615011437 DNA topoisomerase I subunit omega; Validated; Region: PRK07561 114615011438 TOPRIM_TopoIA_TopoI: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to Escherichia coli DNA topoisomerase I. Type IA DNA topoisomerases remove (relax) negative supercoils in...; Region: TOPRIM_TopoIA_TopoI; cd03363 114615011439 active site 114615011440 interdomain interaction site; other site 114615011441 putative metal-binding site [ion binding]; other site 114615011442 nucleotide binding site [chemical binding]; other site 114615011443 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded...; Region: TOP1Ac; cd00186 114615011444 domain I; other site 114615011445 DNA binding groove [nucleotide binding] 114615011446 phosphate binding site [ion binding]; other site 114615011447 domain II; other site 114615011448 domain III; other site 114615011449 nucleotide binding site [chemical binding]; other site 114615011450 catalytic site [active] 114615011451 domain IV; other site 114615011452 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; cl11977 114615011453 ribonuclease R; Region: RNase_R; TIGR02063 114615011454 RNB domain; Region: RNB; pfam00773 114615011455 S1_RNase_R: RNase R C-terminal S1 domain. RNase R is a processive 3' to 5' exoribonuclease, which is a homolog of RNase II. RNase R degrades RNA with secondary structure having a 3' overhang of at least 7 nucleotides. RNase R and PNPase play an...; Region: S1_RNase_R; cd04471 114615011456 RNA binding site [nucleotide binding]; other site 114615011457 Protein of unknown function (DUF983); Region: DUF983; cl02211 114615011458 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or...; Region: Nudix_Hydrolase; cl00447 114615011459 nudix motif; other site 114615011460 nitrilotriacetate monoxygenase oxidizes nitrilotriacetate utilizing reduced flavin mononucleotide (FMNH2) and oxygen. The FMNH2 is provided by an NADH:flavin mononucleotide (FMN) oxidorductase that uses NADH to reduce FMN to FMNH2; Region: Nitrilotriacetate_monoxgenase; cd01095 114615011461 FMN-dependent oxidoreductase, nitrilotriacetate monooxygenase family; Region: FMN_nitrolo; TIGR03860 114615011462 active site 114615011463 non-prolyl cis peptide bond; other site 114615011464 Ribosomal protein L33; Region: Ribosomal_L33; cl00383 114615011465 Globin domain present in Globin-Coupled-Sensors (GCS). These domains detect changes in intracellular concentrations of oxygen, carbon monoxyde, or nitrous oxide, which result in aerotaxis and/or gene regulation. One subgroup, the HemATs, are...; Region: sensor_globin; cd01068 114615011466 heme-binding site [chemical binding]; other site 114615011467 Taxis toward Aspartate and Related amino acids and Homologs (TarH). The Tar chemoreceptor of Escherichia coli mediates attractant responses to aspartate, maltose, and phenol, repellent responses to Ni2+ and Co2+, and thermoresponses. These...; Region: TarH; cl00144 114615011468 Domain of unknown function (DUF1127); Region: DUF1127; cl02276 114615011469 Domain of unknown function (DUF1127); Region: DUF1127; cl02276 114615011470 DNA gyrase subunit B; Provisional; Region: gyrB; PRK14939 114615011471 response regulator PleD; Reviewed; Region: pleD; PRK09581 114615011472 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156 114615011473 active site 114615011474 phosphorylation site [posttranslational modification] 114615011475 intermolecular recognition site; other site 114615011476 dimerization interface [polypeptide binding]; other site 114615011477 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156 114615011478 active site 114615011479 phosphorylation site [posttranslational modification] 114615011480 intermolecular recognition site; other site 114615011481 dimerization interface [polypeptide binding]; other site 114615011482 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 114615011483 metal binding site [ion binding]; metal-binding site 114615011484 active site 114615011485 I-site; other site 114615011486 Response regulator receiver domain; Region: Response_reg; pfam00072 114615011487 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156 114615011488 active site 114615011489 phosphorylation site [posttranslational modification] 114615011490 intermolecular recognition site; other site 114615011491 dimerization interface [polypeptide binding]; other site 114615011492 Protein of unknown function (DUF3572); Region: DUF3572; pfam12096 114615011493 DNA polymerase IV; Provisional; Region: PRK02794 114615011494 DNA Polymerase IV/Kappa; Region: PolY_Pol_IV_kappa; cd03586 114615011495 active site 114615011496 DNA binding site [nucleotide binding] 114615011497 Domain of unknown function (DUF1849); Region: DUF1849; pfam08904 114615011498 This group of proteins belong to a large family of YjgF/YER057c/UK114-like proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence...; Region: YjgF_YER057c_UK114_like_1; cd02199 114615011499 homotrimer interaction site [polypeptide binding]; other site 114615011500 putative active site [active] 114615011501 Catalytic domain of phosphoinositide-specific phospholipase C-like phosphodiesterases superfamily; Region: PI-PLCc_GDPD_SF; cl14615 114615011502 active site 114615011503 catalytic site [active] 114615011504 FemAB family; Region: FemAB; cl11444 114615011505 Protein of unknown function, DUF482; Region: DUF482; pfam04339 114615011506 HINT (histidine triad nucleotide-binding protein) subgroup: Members of this CD belong to the superfamily of histidine triad hydrolases that act on alpha-phosphate of ribonucleotides. This subgroup includes members from all three forms of cellular life...; Region: HINT_subgroup; cd01277 114615011507 HIT family signature motif; other site 114615011508 catalytic residue [active] 114615011509 nicotinate-nucleotide pyrophosphorylase; Provisional; Region: PRK06106 114615011510 Quinolinate phosphoribosyl transferase (QAPRTase or QPRTase), also called nicotinate-nucleotide pyrophosphorylase, is involved in the de novo synthesis of NAD in both prokaryotes and eukaryotes. It catalyses the reaction of quinolinic acid (QA) with 5-...; Region: QPRTase; cd01572 114615011511 dimerization interface [polypeptide binding]; other site 114615011512 active site 114615011513 L-aspartate oxidase; Provisional; Region: PRK07512 114615011514 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 114615011515 domain; Region: Succ_DH_flav_C; pfam02910 114615011516 Quinolinate synthetase A protein; Region: NadA; cl00420 114615011517 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or...; Region: Nudix_Hydrolase; cl00447 114615011518 Escherichia coli YaeB and related proteins; Region: UPF0066; cd09281 114615011519 homodimer interaction site [polypeptide binding]; other site 114615011520 cofactor binding site; other site 114615011521 AzlC protein; Region: AzlC; cl00570 114615011522 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic 'goose-type' lysozymes (GEWL). LTs catalyze...; Region: LT_GEWL; cd00254 114615011523 N-acetyl-D-glucosamine binding site [chemical binding]; other site 114615011524 catalytic residue [active] 114615011525 Sporulation related domain; Region: SPOR; cl10051 114615011526 Glycine/sarcosine/betaine reductase selenoprotein B (GRDB); Region: GRDB; cl06409 114615011527 PEGA domain; Region: PEGA; pfam08308 114615011528 Predicted amidohydrolase [General function prediction only]; Region: COG0388 114615011529 Nitrilases, cyanide hydratase (CH)s, and similar proteins (class 1 nitrilases); Region: nitrilases_CHs; cd07564 114615011530 putative active site [active] 114615011531 catalytic triad [active] 114615011532 putative dimer interface [polypeptide binding]; other site 114615011533 DNA-binding transcriptional activator FeaR; Provisional; Region: PRK09685 114615011534 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 114615011535 Cytochrome c; Region: Cytochrom_C; cl11414 114615011536 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 114615011537 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 114615011538 putative substrate translocation pore; other site 114615011539 Predicted permeases [General function prediction only]; Region: COG0730; cl00498 114615011540 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 114615011541 ATP-dependent Clp protease ATP-binding subunit clpA; Region: ClpA; TIGR02639 114615011542 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes...; Region: AAA; cd00009 114615011543 Walker A motif; other site 114615011544 ATP binding site [chemical binding]; other site 114615011545 Walker B motif; other site 114615011546 arginine finger; other site 114615011547 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes...; Region: AAA; cd00009 114615011548 Walker A motif; other site 114615011549 ATP binding site [chemical binding]; other site 114615011550 Walker B motif; other site 114615011551 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; cl11083 114615011552 ATP-dependent Clp protease adaptor protein ClpS; Region: ClpS; cl00933 114615011553 Phasin protein; Region: Phasin_2; cl11491 114615011554 Beta-lactamase; Region: Beta-lactamase; cl01009 114615011555 Sporulation related domain; Region: SPOR; cl10051 114615011556 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of...; Region: DnaJ; cd06257 114615011557 HSP70 interaction site [polypeptide binding]; other site 114615011558 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 114615011559 ATPase MipZ; Region: MipZ; pfam09140 114615011560 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following...; Region: ParA; cd02042 114615011561 P-loop; other site 114615011562 Magnesium ion binding site [ion binding]; other site 114615011563 Pantoate-beta-alanine ligase; Region: PanC; cd00560 114615011564 pantoate--beta-alanine ligase; Region: panC; TIGR00018 114615011565 active site 114615011566 ATP-binding site [chemical binding]; other site 114615011567 pantoate-binding site; other site 114615011568 HXXH motif; other site 114615011569 Protein of unknown function (DUF1489); Region: DUF1489; cl11570 114615011570 Bacterial protein of unknown function (DUF937); Region: DUF937; cl01528 114615011571 GST_N family, unknown subfamily 1; composed of uncharacterized proteins, predominantly from bacteria, with similarity to GSTs. GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH)...; Region: GST_N_1; cd03043 114615011572 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 114615011573 putative C-terminal domain interface [polypeptide binding]; other site 114615011574 putative GSH binding site (G-site) [chemical binding]; other site 114615011575 putative dimer interface [polypeptide binding]; other site 114615011576 C-terminal, alpha helical domain of an unknown subfamily 3 of Glutathione S-transferases; Region: GST_C_3; cd03194 114615011577 putative substrate binding pocket (H-site) [chemical binding]; other site 114615011578 putative N-terminal domain interface [polypeptide binding]; other site 114615011579 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and...; Region: Aldo_ket_red; cd06660 114615011580 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 114615011581 active site 114615011582 catalytic tetrad [active] 114615011583 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl15258 114615011584 Mg/Co/Ni transporter MgtE (contains CBS domain) [Inorganic ion transport and metabolism]; Region: MgtE; COG2239 114615011585 MgtE intracellular N domain; Region: MgtE_N; cl15244 114615011586 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domain in the magnesium transporter, MgtE. MgtE and its homologs are found in eubacteria, archaebacteria, and eukaryota. Members of this family transport Mg2+ or other...; Region: CBS_pair_Mg_transporter; cd04606 114615011587 Divalent cation transporter; Region: MgtE; cl00786 114615011588 Polysaccharide deacetylase; Region: Polysacc_deac_1; cl12061 114615011589 Polysaccharide deacetylase; Region: Polysacc_deac_1; cl12061 114615011590 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 114615011591 Malate:quinone oxidoreductase (Mqo); Region: Mqo; cl14881 114615011592 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 114615011593 homotrimer interaction site [polypeptide binding]; other site 114615011594 putative active site [active] 114615011595 amidase; Provisional; Region: PRK07486 114615011596 GGCT-like domains, also called AIG2-like family. Gamma-glutamyl cyclotransferase (GGCT) catalyzes the formation of pyroglutamic acid (5-oxoproline) from dipeptides containing gamma-glutamyl, and is a dimeric protein. In Homo sapiens, the protein is...; Region: GGCT_like; cl11426 114615011597 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 114615011598 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 114615011599 non-specific DNA binding site [nucleotide binding]; other site 114615011600 salt bridge; other site 114615011601 sequence-specific DNA binding site [nucleotide binding]; other site 114615011602 Cupin domain; Region: Cupin_2; cl09118 114615011603 PIN (PilT N terminus) domain: Superfamily; Region: PIN_SF; cl14812 114615011604 putative active site [active] 114615011605 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 114615011606 NAD(P) binding site [chemical binding]; other site 114615011607 active site 114615011608 Transcriptional regulator [Transcription]; Region: LysR; COG0583 114615011609 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 114615011610 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 114615011611 dimerization interface [polypeptide binding]; other site 114615011612 Conserved hypothetical protein (Lin0512_fam); Region: Lin0512_fam; cl09807 114615011613 ethanolamine ammonia lyase large subunit; Provisional; Region: PRK15067 114615011614 Ethanolamine ammonia lyase large subunit (EutB); Region: EutB; cl09205 114615011615 Ethanolamine ammonia-lyase light chain (EutC); Region: EutC; cl01762 114615011616 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410 114615011617 LivF (TM1139) is part of the LIV-I bacterial ABC-type two-component transport system that imports neutral, branched-chain amino acids. The E. coli branched-chain amino acid transporter comprises a heterodimer of ABC transporters (LivF and LivG), a...; Region: ABC_TM1139_LivF_branched; cd03224 114615011618 Walker A/P-loop; other site 114615011619 ATP binding site [chemical binding]; other site 114615011620 Q-loop/lid; other site 114615011621 ABC transporter signature motif; other site 114615011622 Walker B; other site 114615011623 D-loop; other site 114615011624 H-loop/switch region; other site 114615011625 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411 114615011626 The Mj1267/LivG ABC transporter subfamily is involved in the transport of the hydrophobic amino acids leucine, isoleucine and valine. MJ1267 is a branched-chain amino acid transporter with 29% similarity to both the LivF and LivG components of the E...; Region: ABC_Mj1267_LivG_branched; cd03219 114615011627 Walker A/P-loop; other site 114615011628 ATP binding site [chemical binding]; other site 114615011629 Q-loop/lid; other site 114615011630 ABC transporter signature motif; other site 114615011631 Walker B; other site 114615011632 D-loop; other site 114615011633 H-loop/switch region; other site 114615011634 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 114615011635 TM-ABC transporter signature motif; other site 114615011636 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 114615011637 TM-ABC transporter signature motif; other site 114615011638 ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683 114615011639 Periplasmic solute-binding domain of active transport proteins that belong to the type I periplasmic binding fold protein family; Region: PBP1_SBP_like_1; cd06327 114615011640 putative ligand binding site [chemical binding]; other site 114615011641 carbon-monoxide dehydrogenase, large subunit; Region: CO_dehy_Mo_lg; TIGR02416 114615011642 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; cl03161 114615011643 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 114615011644 Aerobic-type carbon monoxide dehydrogenase, small subunit CoxS/CutS homologs [Energy production and conversion]; Region: CoxS; COG2080 114615011645 [2Fe-2S] binding domain; Region: Fer2_2; pfam01799 114615011646 FAD binding domain in molybdopterin dehydrogenase; Region: FAD_binding_5; pfam00941 114615011647 CO dehydrogenase flavoprotein C-terminal domain; Region: CO_deh_flav_C; cl08390 114615011648 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 114615011649 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 114615011650 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 114615011651 TOMM system kinase/cyclase multidomain protein; Region: TOMM_kin_cyc; TIGR03903 114615011652 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 114615011653 Walker A motif; other site 114615011654 ATP binding site [chemical binding]; other site 114615011655 cytochrome c oxidase accessory protein FixG; Region: ccoG_rdxA_fixG; TIGR02745 114615011656 4Fe-4S binding domain; Region: Fer4_5; pfam12801 114615011657 Ubp3 associated protein Bre5; Region: Bre5; pfam11614 114615011658 Protein of unknown function (DUF2892); Region: DUF2892; pfam11127 114615011659 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 114615011660 Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841 114615011661 Protein export membrane protein; Region: SecD_SecF; cl14618 114615011662 Carboxymuconolactone decarboxylase family; Region: CMD; cl00460 114615011663 M28, and M42; Region: Zinc_peptidase_like; cl14876 114615011664 The ABC transporter subfamily specific for the transport of dipeptides, oligopeptides (OppD), and nickel (NikDE). The NikABCDE system of E. coli belongs to this family and is composed of the periplasmic binding protein NikA, two integral membrane...; Region: ABC_NikE_OppD_transporters; cd03257 114615011665 Walker A/P-loop; other site 114615011666 ATP binding site [chemical binding]; other site 114615011667 Q-loop/lid; other site 114615011668 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 114615011669 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 114615011670 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cl00427 114615011671 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cl00427 114615011672 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cl01709 114615011673 UTRA domain; Region: UTRA; cl01230 114615011674 dihydroxyacetone kinase subunit DhaK; Provisional; Region: PRK14481; cl10557 114615011675 Dihydroxyacetone kinase [Carbohydrate transport and metabolism]; Region: DAK1; COG2376 114615011676 Phosphoenolpyruvate-protein kinase (PTS system EI component in bacteria) [Carbohydrate transport and metabolism]; Region: PtsA; COG1080 114615011677 PEP-utilising enzyme, N-terminal; Region: PEP-utilisers_N; pfam05524 114615011678 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; cl01586 114615011679 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl09155 114615011680 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367 114615011681 dimerization domain swap beta strand [polypeptide binding]; other site 114615011682 regulatory protein interface [polypeptide binding]; other site 114615011683 active site 114615011684 regulatory phosphorylation site [posttranslational modification]; other site 114615011685 PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_man; cl00025 114615011686 active pocket/dimerization site; other site 114615011687 active site 114615011688 phosphorylation site [posttranslational modification] 114615011689 DAK2 domain; Region: Dak2; cl03685 114615011690 ABC-type sugar transport systems, ATPase components [Carbohydrate transport and metabolism]; Region: MalK; COG3839 114615011691 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 114615011692 Walker A/P-loop; other site 114615011693 ATP binding site [chemical binding]; other site 114615011694 Q-loop/lid; other site 114615011695 ABC transporter signature motif; other site 114615011696 Walker B; other site 114615011697 D-loop; other site 114615011698 H-loop/switch region; other site 114615011699 glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650 114615011700 The N-terminal ATPase domain of the maltose transporter, MalK. ATP binding cassette (ABC) proteins function from bacteria to human, mediating the translocation of substances into and out of cells or organelles. ABC transporters contain two...; Region: ABC_MalK_N; cd03301 114615011701 Walker A/P-loop; other site 114615011702 ATP binding site [chemical binding]; other site 114615011703 Q-loop/lid; other site 114615011704 ABC transporter signature motif; other site 114615011705 Walker B; other site 114615011706 D-loop; other site 114615011707 H-loop/switch region; other site 114615011708 TOBE domain; Region: TOBE_2; cl01440 114615011709 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 114615011710 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261 114615011711 dimer interface [polypeptide binding]; other site 114615011712 conserved gate region; other site 114615011713 putative PBP binding loops; other site 114615011714 ABC-ATPase subunit interface; other site 114615011715 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cl00427 114615011716 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 114615011717 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261 114615011718 dimer interface [polypeptide binding]; other site 114615011719 conserved gate region; other site 114615011720 putative PBP binding loops; other site 114615011721 ABC-ATPase subunit interface; other site 114615011722 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 114615011723 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 114615011724 The (Largely Gram-negative Bacterial) Hydrophobe/Amphiphile Efflux-1 (HAE1) Family; Region: 2A0602; TIGR00915 114615011725 periplasmic multidrug efflux lipoprotein precursor; Reviewed; Region: PRK09578 114615011726 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 114615011727 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 114615011728 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01039 114615011729 Flagellar hook-length control protein FliK; Region: Flg_hook; cl15269 114615011730 ATP12 chaperone protein; Region: ATP12; cl02228 114615011731 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 114615011732 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cl09940 114615011733 PseudoU_synth_RsuA/RluD: Pseudouridine synthase, RsuA/RluD family. This group is comprised of eukaryotic, bacterial and archeal proteins similar to eight site specific Escherichia coli pseudouridine synthases: RsuA, RluA, RluB, RluC, RluD, RluE, RluF...; Region: PseudoU_synth_RluCD_like; cd02869 114615011734 active site 114615011735 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 114615011736 substrate binding pocket [chemical binding]; other site 114615011737 recombination factor protein RarA; Reviewed; Region: PRK13342 114615011738 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes...; Region: AAA; cd00009 114615011739 Walker A motif; other site 114615011740 ATP binding site [chemical binding]; other site 114615011741 Walker B motif; other site 114615011742 arginine finger; other site 114615011743 MgsA AAA+ ATPase C terminal; Region: MgsA_C; pfam12002 114615011744 periplasmic serine protease, Do/DeqQ family; Region: degP_htrA_DO; TIGR02037 114615011745 Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic...; Region: Tryp_SPc; cl00149 114615011746 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind C-...; Region: PDZ_serine_protease; cd00987 114615011747 protein binding site [polypeptide binding]; other site 114615011748 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind C-...; Region: PDZ_serine_protease; cd00987 114615011749 protein binding site [polypeptide binding]; other site 114615011750 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 114615011751 Arginate lyase and other MDR family members; Region: AL_MDR; cd08252 114615011752 zinc-binding alcohol dehydrogenase family protein; Region: adh_fam_1; TIGR02817 114615011753 putative NAD(P) binding site [chemical binding]; other site 114615011754 dimer interface [polypeptide binding]; other site 114615011755 Beta-lactamase; Region: Beta-lactamase; cl01009 114615011756 Isoprenylcysteine carboxyl methyltransferase (ICMT) family; Region: ICMT; cl00763 114615011757 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 114615011758 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cl11420 114615011759 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 114615011760 NmrA-like family; Region: NmrA; pfam05368 114615011761 NAD(P) binding site [chemical binding]; other site 114615011762 active site 114615011763 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 114615011764 Uncharacterized conserved protein [Function unknown]; Region: COG3945 114615011765 Glutathione-dependent formaldehyde-activating enzyme; Region: GFA; cl01553 114615011766 Uncharacterized homologs of Site-2 protease (S2P), zinc metalloproteases (MEROPS family M50) which cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of the...; Region: S2P-M50_like_1; cd06158 114615011767 active site 114615011768 putative substrate binding region [chemical binding]; other site 114615011769 Gram-negative bacterial tonB protein; Region: TonB; cl10048 114615011770 Biopolymer transport protein ExbD/TolR; Region: ExbD; cl00537 114615011771 MotA/TolQ/ExbB proton channel family; Region: MotA_ExbB; cl00568 114615011772 Biopolymer transport proteins [Intracellular trafficking and secretion]; Region: TolQ; COG0811 114615011773 2OG-Fe(II) oxygenase superfamily; Region: 2OG-FeII_Oxy; cl01206 114615011774 Outer membrane receptor for monomeric catechols [Inorganic ion transport and metabolism]; Region: Fiu; COG4774 114615011775 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 114615011776 N-terminal plug; other site 114615011777 ligand-binding site [chemical binding]; other site 114615011778 transcriptional regulator SlyA; Provisional; Region: PRK03573 114615011779 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 114615011780 multidrug efflux system subunit MdtA; Provisional; Region: PRK11556 114615011781 multidrug efflux system subunit MdtB; Provisional; Region: PRK10503 114615011782 Protein export membrane protein; Region: SecD_SecF; cl14618 114615011783 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi...; Region: TPR; cd00189 114615011784 binding surface 114615011785 TPR motif; other site 114615011786 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi...; Region: TPR; cd00189 114615011787 TPR motif; other site 114615011788 binding surface 114615011789 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi...; Region: TPR; cd00189 114615011790 binding surface 114615011791 TPR motif; other site 114615011792 Predicted O-linked N-acetylglucosamine transferase, SPINDLY family [Posttranslational modification, protein turnover, chaperones]; Region: Spy; COG3914 114615011793 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily requires a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_26; cd04685 114615011794 nudix motif; other site 114615011795 The Class III extradiol dioxygenase, homoprotocatechuate 2,3-dioxygenase, catalyzes the key ring cleavage step in the metabolism of homoprotocatechuate; Region: HPCD; cd07370 114615011796 Catalytic LigB subunit of aromatic ring-opening dioxygenase; Region: LigB; pfam02900 114615011797 putative active site [active] 114615011798 putative metal binding site [ion binding]; other site 114615011799 Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071 114615011800 Alpha-crystallin domain (ACD) of alpha-crystallin-type small(s) heat shock proteins (Hsps). sHsps are small stress induced proteins with monomeric masses between 12 -43 kDa, whose common feature is the Alpha-crystallin domain (ACD). sHsps are...; Region: ACD_sHsps-like; cd06464 114615011801 putative dimer interface [polypeptide binding]; other site 114615011802 Domain of unknown function DUF87; Region: DUF87; pfam01935 114615011803 AAA-like domain; Region: AAA_10; pfam12846 114615011804 transcriptional regulator SlyA; Provisional; Region: PRK03573 114615011805 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 114615011806 Fusaric acid resistance protein family; Region: FUSC; pfam04632 114615011807 Bacterial protein of unknown function (DUF939); Region: DUF939; cl12136 114615011808 Bacterial protein of unknown function (DUF939); Region: DUF939; cl12136 114615011809 Multidrug resistance efflux pump [Defense mechanisms]; Region: EmrA; COG1566 114615011810 uncharacterized peroxidase-related enzyme; Region: peroxid_rel; TIGR01926 114615011811 Carboxymuconolactone decarboxylase family; Region: CMD; cl00460 114615011812 Putative ParB-like nuclease; Region: ParBc_2; cl01772 114615011813 Phosphopantetheine attachment site; Region: PP-binding; cl09936 114615011814 FabZ is a 17kD beta-hydroxyacyl-acyl carrier protein (ACP) dehydratase that primarily catalyzes the dehydration of beta-hydroxyacyl-ACP to trans-2-acyl-ACP, the third step in the elongation phase of the bacterial/ plastid, type II, fatty-acid...; Region: FabZ; cd01288 114615011815 3-oxoacyl-(acyl carrier protein) synthase II; Reviewed; Region: PRK06519 114615011816 Condensing enzymes; Family of enzymes that catalyze a (decarboxylating or non-decarboxylating) Claisen-like condensation reaction. Members are share strong structural similarity, and are involved in the synthesis and degradation of fatty acids, and the...; Region: cond_enzymes; cl09938 114615011817 active site 114615011818 3-oxoacyl-(acyl carrier protein) synthase II; Reviewed; Region: PRK06501 114615011819 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 114615011820 dimer interface [polypeptide binding]; other site 114615011821 active site 114615011822 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LABLAT-like; Region: LPLAT_LABLAT-like; cd07984 114615011823 putative acyl-acceptor binding pocket; other site 114615011824 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_19; cd07262 114615011825 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 114615011826 Spermidine/putrescine-binding periplasmic protein [Amino acid transport and metabolism]; Region: PotD; COG0687 114615011827 hypothetical protein; Provisional; Region: PRK08912 114615011828 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 114615011829 pyridoxal 5'-phosphate binding site [chemical binding]; other site 114615011830 homodimer interface [polypeptide binding]; other site 114615011831 catalytic residue [active] 114615011832 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cl00125 114615011833 active site residue [active] 114615011834 K+ potassium transporter; Region: K_trans; cl01227 114615011835 potassium uptake protein; Region: kup; TIGR00794 114615011836 K+ potassium transporter; Region: K_trans; cl01227 114615011837 potassium uptake protein; Region: kup; TIGR00794 114615011838 Flagellar motor protein [Cell motility and secretion]; Region: MotB; COG1360 114615011839 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 114615011840 ligand binding site [chemical binding]; other site 114615011841 MotA/TolQ/ExbB proton channel family; Region: MotA_ExbB; cl00568 114615011842 Flagellar motor component [Cell motility and secretion]; Region: MotA; COG1291 114615011843 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via trans-...; Region: HisKA; cd00082 114615011844 dimer interface [polypeptide binding]; other site 114615011845 phosphorylation site [posttranslational modification] 114615011846 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 114615011847 ATP binding site [chemical binding]; other site 114615011848 Mg2+ binding site [ion binding]; other site 114615011849 G-X-G motif; other site 114615011850 Response regulator receiver domain; Region: Response_reg; pfam00072 114615011851 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156 114615011852 active site 114615011853 phosphorylation site [posttranslational modification] 114615011854 intermolecular recognition site; other site 114615011855 dimerization interface [polypeptide binding]; other site 114615011856 Demethylmenaquinone methyltransferase; Region: Methyltransf_6; cl00480 114615011857 Phosphatidylserine synthase [Lipid metabolism]; Region: PssA; COG1183 114615011858 CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; cl00453 114615011859 Phosphatidylserine decarboxylase; Region: PS_Dcarbxylase; cl03656 114615011860 ABC transporter transmembrane region; Region: ABC_membrane; cl00549 114615011861 ABC-type transport system involved in Fe-S cluster assembly, permease and ATPase components [Posttranslational modification, protein turnover, chaperones]; Region: ATM1; COG5265 114615011862 ATM1 is an ABC transporter that is expressed in the mitochondria. Although the specific function of ATM1 is unknown, its disruption results in the accumulation of excess mitochondrial iron, loss of mitochondrial cytochromes, oxidative damage to...; Region: ABCC_ATM1_transporter; cd03253 114615011863 Walker A/P-loop; other site 114615011864 ATP binding site [chemical binding]; other site 114615011865 Q-loop/lid; other site 114615011866 ABC transporter signature motif; other site 114615011867 Walker B; other site 114615011868 D-loop; other site 114615011869 H-loop/switch region; other site 114615011870 DNA recombination-mediator protein A; Region: DNA_processg_A; cl00695 114615011871 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_19; cd07262 114615011872 putative alpha-isopropylmalate/homocitrate synthase family transferase; Provisional; Region: PRK12344 114615011873 Desulfobacterium autotrophicum LeuA3 and related proteins, N-terminal catalytic TIM barrel domain; Region: DRE_TIM_LeuA3; cd07941 114615011874 active site 114615011875 catalytic residues [active] 114615011876 metal binding site [ion binding]; metal-binding site 114615011877 LeuA allosteric (dimerisation) domain; Region: LeuA_dimer; cl07212 114615011878 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 114615011879 Coenzyme A binding pocket [chemical binding]; other site 114615011880 cysteinyl-tRNA synthetase; Validated; Region: cysS; PRK00260 114615011881 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 114615011882 active site 114615011883 HIGH motif; other site 114615011884 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 114615011885 KMSKS motif; other site 114615011886 Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020 114615011887 Protein of unknown function (DUF2865); Region: DUF2865; pfam11064 114615011888 Predicted amidohydrolase [General function prediction only]; Region: COG0388 114615011889 Glutamine aminotransferase (GAT, glutaminase) domain of glutamine-dependent NAD synthetases (class 7 and 8 nitrilases); Region: GAT_Gln-NAD-synth; cd07570 114615011890 multimer interface [polypeptide binding]; other site 114615011891 active site 114615011892 catalytic triad [active] 114615011893 protein interface 1 [polypeptide binding]; other site 114615011894 Adenine nucleotide alpha hydrolases superfamily including N type ATP PPases, ATP sulphurylases Universal Stress Response protein and electron transfer flavoprotein (ETF). The domain forms a apha/beta/apha fold which binds to Adenosine nucleotide; Region: AANH_like; cl00292 114615011895 Ligand Binding Site [chemical binding]; other site 114615011896 Prokaryotic diacylglycerol kinase; Region: DAGK_prokar; cl00526 114615011897 Class-II DAHP synthetase family; Region: DAHP_synth_2; cl03230 114615011898 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 114615011899 dimerization interface [polypeptide binding]; other site 114615011900 putative DNA binding site [nucleotide binding]; other site 114615011901 putative Zn2+ binding site [ion binding]; other site 114615011902 Putative hydrophobic ligand-binding SRPBCC domain of Micromonospora echinospora CalC, human Aha1, and related proteins; Region: SRPBCC_CalC_Aha1-like; cd07814 114615011903 putative hydrophobic ligand binding site [chemical binding]; other site 114615011904 Cupin domain; Region: Cupin_2; cl09118 114615011905 glutathione reductase; Validated; Region: PRK06116 114615011906 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 114615011907 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 114615011908 Uncharacterized protein conserved in bacteria (DUF2059); Region: DUF2059; cl01243 114615011909 RPI_A: Ribose 5-phosphate isomerase type A (RPI_A) subfamily; RPI catalyzes the reversible conversion of ribose-5-phosphate to ribulose 5-phosphate, the first step of the non-oxidative branch of the pentose phosphate pathway. This reaction leads to the...; Region: RPI_A; cd01398 114615011910 tetramer (dimer of dimers) interface [polypeptide binding]; other site 114615011911 active site 114615011912 dimer interface [polypeptide binding]; other site 114615011913 Predicted phosphatases [General function prediction only]; Region: Gph; COG0546 114615011914 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others...; Region: HAD_like; cd01427 114615011915 motif II; other site 114615011916 molybdenum cofactor biosynthesis protein A; Reviewed; Region: moaA; PRK00164 114615011917 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster...; Region: Radical_SAM; cd01335 114615011918 FeS/SAM binding site; other site 114615011919 Molybdenum Cofactor Synthesis C; Region: Mob_synth_C; pfam06463 114615011920 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cl12011 114615011921 Cation efflux family; Region: Cation_efflux; cl00316 114615011922 Tripartite ATP-independent periplasmic transporters, DctQ component; Region: DctQ; cl01181 114615011923 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl09110 114615011924 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 114615011925 Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices connected by an extended linker. The...; Region: HAMP; cl01054 114615011926 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via trans-...; Region: HisKA; cd00082 114615011927 dimer interface [polypeptide binding]; other site 114615011928 phosphorylation site [posttranslational modification] 114615011929 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 114615011930 ATP binding site [chemical binding]; other site 114615011931 Mg2+ binding site [ion binding]; other site 114615011932 G-X-G motif; other site 114615011933 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 114615011934 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156 114615011935 active site 114615011936 phosphorylation site [posttranslational modification] 114615011937 intermolecular recognition site; other site 114615011938 dimerization interface [polypeptide binding]; other site 114615011939 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase...; Region: trans_reg_C; cd00383 114615011940 DNA binding site [nucleotide binding] 114615011941 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 114615011942 Putative silver efflux pump [Inorganic ion transport and metabolism]; Region: COG3696 114615011943 NodT family; Region: outer_NodT; TIGR01845 114615011944 Outer membrane efflux protein; Region: OEP; pfam02321 114615011945 Bacterial extracellular solute-binding protein, family 7; Region: SBP_bac_7; cl00710 114615011946 Bacterial extracellular solute-binding protein, family 7; Region: SBP_bac_7; cl00710 114615011947 MRP (Multiple Resistance and pH adaptation) is a homologue of the Fer4_NifH superfamily. Like the other members of the superfamily, MRP contains a ATP-binding domain at the N-termini. It is found in bacteria as a membrane-spanning protein and functions...; Region: MRP-like; cd02037 114615011948 Ras-like GTPase superfamily. The Ras-like superfamily of small GTPases consists of several families with an extremely high degree of structural and functional similarity. The Ras superfamily is divided into at least four families in eukaryotes: the Ras...; Region: Ras_like_GTPase; cl10444 114615011949 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_9; cd07245 114615011950 dimer interface [polypeptide binding]; other site 114615011951 putative metal binding site [ion binding]; other site 114615011952 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 114615011953 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084 114615011954 NAD(P) binding pocket [chemical binding]; other site 114615011955 Phage Tail Collar Domain; Region: Collar; pfam07484 114615011956 Phage Tail Collar Domain; Region: Collar; pfam07484 114615011957 Phage Tail Collar Domain; Region: Collar; pfam07484 114615011958 Microcystin-dependent protein [Function unknown]; Region: MdpB; COG4675 114615011959 TonB-dependent siderophore receptor; Region: TonB-siderophor; TIGR01783 114615011960 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 114615011961 N-terminal plug; other site 114615011962 ligand-binding site [chemical binding]; other site 114615011963 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via trans-...; Region: HisKA; cd00082 114615011964 dimer interface [polypeptide binding]; other site 114615011965 phosphorylation site [posttranslational modification] 114615011966 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 114615011967 ATP binding site [chemical binding]; other site 114615011968 Mg2+ binding site [ion binding]; other site 114615011969 G-X-G motif; other site 114615011970 Protein of unknown function (DUF1289); Region: DUF1289; cl01304 114615011971 Bacterial aspartate proteases, retropepsin-like protease family; Region: retropepsin_like_bacteria; cd05483 114615011972 catalytic motif [active] 114615011973 Catalytic residue [active] 114615011974 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 114615011975 histidinol-phosphate aminotransferase; Region: hisC; TIGR01141 114615011976 pyridoxal 5'-phosphate binding site [chemical binding]; other site 114615011977 homodimer interface [polypeptide binding]; other site 114615011978 catalytic residue [active] 114615011979 tRNA-dihydrouridine synthase A; Provisional; Region: PRK11815 114615011980 Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and...; Region: DUS_like_FMN; cd02801 114615011981 FMN binding site [chemical binding]; other site 114615011982 active site 114615011983 catalytic residues [active] 114615011984 substrate binding site [chemical binding]; other site 114615011985 Exostosin family; Region: Exostosin; pfam03016 114615011986 Uncharacterized protein involved in exopolysaccharide biosynthesis [Cell envelope biogenesis, outer membrane]; Region: GumC; COG3206 114615011987 Chain length determinant protein; Region: Wzz; cl01623 114615011988 Glycosyl hydrolase family 26; Region: Glyco_hydro_26; cl09200 114615011989 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 114615011990 ExoA is involved in the biosynthesis of succinoglycan; Region: Succinoglycan_BP_ExoA; cd02525 114615011991 Ligand binding site [chemical binding]; other site 114615011992 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and...; Region: Aldo_ket_red; cd06660 114615011993 active site 114615011994 catalytic tetrad [active] 114615011995 Choline dehydrogenase and related flavoproteins [Amino acid transport and metabolism]; Region: BetA; COG2303 114615011996 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 114615011997 sugar transferase, PEP-CTERM/EpsH1 system associated; Region: stp1; TIGR03087 114615011998 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 114615011999 Bacterial sugar transferase; Region: Bac_transf; cl00939 114615012000 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cd02440 114615012001 S-adenosylmethionine binding site [chemical binding]; other site 114615012002 Imidazolonepropionase and related amidohydrolases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: HutI; COG1228 114615012003 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have...; Region: metallo-dependent_hydrolases; cl00281 114615012004 Metallo-dependent hydrolases, subgroup A is part of the superfamily of metallo-dependent hydrolases, a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the...; Region: Met_dep_hydrolase_A; cd01299 114615012005 active site 114615012006 Tripartite ATP-independent periplasmic transporters, DctQ component; Region: DctQ; cl01181 114615012007 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl09110 114615012008 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl09110 114615012009 Bacterial extracellular solute-binding protein, family 7; Region: SBP_bac_7; cl00710 114615012010 Transketolase, C-terminal subunit [Carbohydrate transport and metabolism]; Region: COG3958 114615012011 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 114615012012 PYR/PP interface [polypeptide binding]; other site 114615012013 dimer interface [polypeptide binding]; other site 114615012014 TPP binding site [chemical binding]; other site 114615012015 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 114615012016 Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012 114615012017 TPP-binding site [chemical binding]; other site 114615012018 dimer interface [polypeptide binding]; other site 114615012019 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 114615012020 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 114615012021 NAD(P) binding site [chemical binding]; other site 114615012022 active site 114615012023 DNA-binding transcriptional activator GcvA; Provisional; Region: PRK11139 114615012024 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 114615012025 HvR and beta-lactamase regulators, and that of other closely related homologs; contains the type 2 periplasmic binding fold; Region: PBP2_GcdR_TrpI_HvrB_AmpR_like; cd08432 114615012026 dimerization interface [polypeptide binding]; other site 114615012027 substrate binding pocket [chemical binding]; other site 114615012028 NADPH-dependent FMN reductase; Region: FMN_red; cl00438 114615012029 Gluconolactonase [Carbohydrate transport and metabolism]; Region: COG3386 114615012030 Isochorismatase family; Region: Isochorismatase; pfam00857 114615012031 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cd00431 114615012032 catalytic triad [active] 114615012033 conserved cis-peptide bond; other site 114615012034 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 114615012035 Predicted metal-dependent hydrolase of the TIM-barrel fold [General function prediction only]; Region: COG3618 114615012036 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have...; Region: metallo-dependent_hydrolases; cl00281 114615012037 Protein containing von Willebrand factor type A (vWA) domain [General function prediction only]; Region: CoxE; COG3552 114615012038 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057 114615012039 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes...; Region: AAA; cd00009 114615012040 AAA domain (dynein-related subfamily); Region: AAA_5; pfam07728 114615012041 ATP binding site [chemical binding]; other site 114615012042 Walker A motif; other site 114615012043 Walker B motif; other site 114615012044 arginine finger; other site 114615012045 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 114615012046 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; cl03161 114615012047 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 114615012048 Aerobic-type carbon monoxide dehydrogenase, small subunit CoxS/CutS homologs [Energy production and conversion]; Region: CoxS; COG2080 114615012049 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cl00159 114615012050 [2Fe-2S] binding domain; Region: Fer2_2; pfam01799 114615012051 Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM/CutM homologs [Energy production and conversion]; Region: CoxM; COG1319 114615012052 CO dehydrogenase flavoprotein C-terminal domain; Region: CO_deh_flav_C; cl08390 114615012053 Pyrabactin resistance 1 (PYR1), PYR1-like (PYL), regulatory component of abscisic acid receptors (RCARs), and related proteins; Region: PYR_PYL_RCAR_like; cd07821 114615012054 putative hydrophobic ligand binding site [chemical binding]; other site 114615012055 protein interface [polypeptide binding]; other site 114615012056 gate; other site 114615012057 Pyrabactin resistance 1 (PYR1), PYR1-like (PYL), regulatory component of abscisic acid receptors (RCARs), and related proteins; Region: PYR_PYL_RCAR_like; cd07821 114615012058 putative hydrophobic ligand binding site [chemical binding]; other site 114615012059 protein interface [polypeptide binding]; other site 114615012060 gate; other site 114615012061 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2268 114615012062 Band_7_flotillin: a subgroup of the band 7 domain of flotillin (reggie) like proteins. This subgroup contains proteins similar to stomatin, prohibitin, flotillin, HlfK/C and podicin. These two proteins are lipid raft-associated. Individual proteins...; Region: Band_7_flotillin; cd03399 114615012063 Predicted TIM-barrel enzyme, possibly a dioxygenase [General function prediction only]; Region: COG5564 114615012064 TIM-barrel signal transduction protein; Region: TIM-br_sig_trns; pfam09370 114615012065 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410 114615012066 LivF (TM1139) is part of the LIV-I bacterial ABC-type two-component transport system that imports neutral, branched-chain amino acids. The E. coli branched-chain amino acid transporter comprises a heterodimer of ABC transporters (LivF and LivG), a...; Region: ABC_TM1139_LivF_branched; cd03224 114615012067 Walker A/P-loop; other site 114615012068 ATP binding site [chemical binding]; other site 114615012069 Q-loop/lid; other site 114615012070 ABC transporter signature motif; other site 114615012071 Walker B; other site 114615012072 D-loop; other site 114615012073 H-loop/switch region; other site 114615012074 Uncharacterised protein family (UPF0261); Region: UPF0261; cl02262 114615012075 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411 114615012076 The Mj1267/LivG ABC transporter subfamily is involved in the transport of the hydrophobic amino acids leucine, isoleucine and valine. MJ1267 is a branched-chain amino acid transporter with 29% similarity to both the LivF and LivG components of the E...; Region: ABC_Mj1267_LivG_branched; cd03219 114615012077 Walker A/P-loop; other site 114615012078 ATP binding site [chemical binding]; other site 114615012079 Q-loop/lid; other site 114615012080 ABC transporter signature motif; other site 114615012081 Walker B; other site 114615012082 D-loop; other site 114615012083 H-loop/switch region; other site 114615012084 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 114615012085 TM-ABC transporter signature motif; other site 114615012086 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 114615012087 TM-ABC transporter signature motif; other site 114615012088 Cupin domain; Region: Cupin_2; cl09118 114615012089 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 114615012090 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 114615012091 ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683 114615012092 Type I periplasmic binding component of active transport systems that are predicted be involved in anaerobic biodegradation of alkylbenzenes such as toluene and ethylbenzene; Region: PBP1_alkylbenzenes_like; cd06360 114615012093 putative ligand binding site [chemical binding]; other site 114615012094 Periplasmic sugar-binding component of uncharacterized ABC-type transport systems that are members of the pentose/hexose sugar-binding protein family of the type I periplasmic binding protein superfamily; Region: PBP1_ABC_sugar_binding_like_1; cd06300 114615012095 putative ligand binding site [chemical binding]; other site 114615012096 ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129 114615012097 This family represents the domain I of the carbohydrate uptake proteins that transport only monosaccharides (Monos). The Carb_Monos family is involved in the uptake of monosaccharides, such as pentoses (such as xylose, arabinose, and ribose) and...; Region: ABC_Carb_Monos_I; cd03216 114615012098 Walker A/P-loop; other site 114615012099 ATP binding site [chemical binding]; other site 114615012100 Q-loop/lid; other site 114615012101 ABC transporter signature motif; other site 114615012102 Walker B; other site 114615012103 D-loop; other site 114615012104 H-loop/switch region; other site 114615012105 This family represents domain II of the carbohydrate uptake proteins that transport only monosaccharides (Monos). The Carb_Monos family is involved in the uptake of monosaccharides, such as pentoses (such as xylose, arabinose, and ribose) and hexoses (; Region: ABC_Carb_Monos_II; cd03215 114615012106 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 114615012107 TM-ABC transporter signature motif; other site 114615012108 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 114615012109 TM-ABC transporter signature motif; other site 114615012110 glycerol-3-phosphate dehydrogenase; Provisional; Region: PRK13369 114615012111 Class II Aldolase and Adducin head (N-terminal) domain. Aldolases are ubiquitous enzymes catalyzing central steps of carbohydrate metabolism. Based on enzymatic mechanisms, this superfamily has been divided into two distinct classes (Class I and II)...; Region: Aldolase_II; cl00214 114615012112 intersubunit interface [polypeptide binding]; other site 114615012113 active site 114615012114 Zn2+ binding site [ion binding]; other site 114615012115 Phosphoglycerate dehydrogenase and related dehydrogenases [Amino acid transport and metabolism]; Region: SerA; COG0111 114615012116 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 114615012117 Sugar (pentulose and hexulose) kinases [Carbohydrate transport and metabolism]; Region: XylB; COG1070 114615012118 L-xylulose kinases; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_L-XK; cd07802 114615012119 putative N- and C-terminal domain interface [polypeptide binding]; other site 114615012120 putative active site [active] 114615012121 putative MgATP binding site [chemical binding]; other site 114615012122 catalytic site [active] 114615012123 metal binding site [ion binding]; metal-binding site 114615012124 putative xylulose binding site [chemical binding]; other site 114615012125 ABC-type sugar transport systems, ATPase components [Carbohydrate transport and metabolism]; Region: MalK; COG3839 114615012126 ABC Carbohydrate and Solute Transporters-like subgroup. This family is comprised of proteins involved in the transport of apparently unrelated solutes and proteins specific for di- and oligosaccharides and polyols. ABC transporters are a large family...; Region: ABC_Carb_Solutes_like; cd03259 114615012127 Walker A/P-loop; other site 114615012128 ATP binding site [chemical binding]; other site 114615012129 Q-loop/lid; other site 114615012130 ABC transporter signature motif; other site 114615012131 Walker B; other site 114615012132 D-loop; other site 114615012133 H-loop/switch region; other site 114615012134 TOBE domain; Region: TOBE_2; cl01440 114615012135 ABC-type sugar transport systems, ATPase components [Carbohydrate transport and metabolism]; Region: MalK; COG3839 114615012136 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 114615012137 Walker A/P-loop; other site 114615012138 ATP binding site [chemical binding]; other site 114615012139 Q-loop/lid; other site 114615012140 ABC transporter signature motif; other site 114615012141 Walker B; other site 114615012142 D-loop; other site 114615012143 H-loop/switch region; other site 114615012144 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 114615012145 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cl00427 114615012146 ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555 114615012147 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261 114615012148 dimer interface [polypeptide binding]; other site 114615012149 conserved gate region; other site 114615012150 putative PBP binding loops; other site 114615012151 ABC-ATPase subunit interface; other site 114615012152 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 114615012153 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 114615012154 Transcriptional regulator, contains sigma factor-related N-terminal domain [Transcription]; Region: DeoR; COG2390 114615012155 Putative sugar-binding domain; Region: Sugar-bind; pfam04198 114615012156 FGGY family of carbohydrate kinases; Region: FGGY; cl08364 114615012157 N- and C-terminal domain interface [polypeptide binding]; other site 114615012158 D-xylulose kinase; Region: XylB; TIGR01312 114615012159 active site 114615012160 MgATP binding site [chemical binding]; other site 114615012161 catalytic site [active] 114615012162 metal binding site [ion binding]; metal-binding site 114615012163 carbohydrate binding site [chemical binding]; other site 114615012164 HAD-superfamily class IIA hydrolase, TIGR01459; Region: HAD-SF-IIA-hyp4 114615012165 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others...; Region: HAD_like; cd01427 114615012166 active site 114615012167 motif I; other site 114615012168 motif II; other site 114615012169 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others...; Region: HAD_like; cd01427 114615012170 Uncharacterized conserved protein [Function unknown]; Region: COG3347 114615012171 Class II Aldolase and Adducin head (N-terminal) domain. Aldolases are ubiquitous enzymes catalyzing central steps of carbohydrate metabolism. Based on enzymatic mechanisms, this superfamily has been divided into two distinct classes (Class I and II)...; Region: Aldolase_II; cl00214 114615012172 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109 114615012173 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 114615012174 Glutathione S-transferase (GST) family, N-terminal domain; a large, diverse group of cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of endogenous and xenobiotic...; Region: GST_N_family; cd00570 114615012175 C-terminal domain interface [polypeptide binding]; other site 114615012176 GSH binding site (G-site) [chemical binding]; other site 114615012177 dimer interface [polypeptide binding]; other site 114615012178 short chain dehydrogenase; Provisional; Region: PRK12939 114615012179 classical (c) SDRs; Region: SDR_c; cd05233 114615012180 NAD(P) binding site [chemical binding]; other site 114615012181 active site 114615012182 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 114615012183 C-terminal, alpha helical domain of the Glutathione S-transferase family; Region: GST_C_family; cl02776 114615012184 N-terminal domain interface [polypeptide binding]; other site 114615012185 ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683 114615012186 Periplasmic solute-binding domain of active transport proteins that belong to the type I periplasmic binding fold protein family; Region: PBP1_SBP_like_1; cd06327 114615012187 putative ligand binding site [chemical binding]; other site 114615012188 CoA-transferase family III; Region: CoA_transf_3; cl00778 114615012189 DNA-binding transcriptional activator XapR; Provisional; Region: PRK09986 114615012190 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 114615012191 The C-terminal substrate binding domain of LysR-type transcrptional regulator BudR, which is responsible for activation of the expression of the butanediol operon genes; contains the type 2 periplasmic binding fold; Region: PBP2_BudR; cd08451 114615012192 putative dimerization interface [polypeptide binding]; other site 114615012193 putative substrate binding pocket [chemical binding]; other site 114615012194 Chain length determinant protein; Region: Wzz; cl01623 114615012195 exopolysaccharide transport protein family; Region: eps_transp_fam; TIGR01005 114615012196 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 114615012197 Walker A motif; other site 114615012198 ATP binding site [chemical binding]; other site 114615012199 Walker B motif; other site 114615012200 The glycosyltransferase WecG/TagA superfamily contains Escherichia coli WecG, Bacillus subtilis TagA and related proteins. E. coli WecG is believed to be a UDP-N-acetyl-D-mannosaminuronic acid transferase, and is involved in enterobacterial common...; Region: Glyco_transf_WecG_TagA; cd06533 114615012201 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 114615012202 anti sigma factor interaction site; other site 114615012203 regulatory phosphorylation site [posttranslational modification]; other site 114615012204 CESA_like is the cellulose synthase superfamily; Region: CESA_like; cd06423 114615012205 DXD motif; other site 114615012206 Predicted acyltransferases [Lipid metabolism]; Region: COG1835 114615012207 Predicted ATP-grasp enzyme [General function prediction only]; Region: COG3919 114615012208 Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072 114615012209 exosortase 1 system-associated amidotransferase 1; Region: eps_aminotran_1; TIGR03108 114615012210 Glutamine amidotransferases class-II (GATase) asparagine synthase_B type. Asparagine synthetase B catalyses the ATP-dependent conversion of aspartate to asparagine. This enzyme is a homodimer, with each monomer composed of a glutaminase domain and a...; Region: AsnB; cd00712 114615012211 active site 114615012212 dimer interface [polypeptide binding]; other site 114615012213 The C-terminal domain of Asparagine Synthase B. This domain is always found associated n-terminal amidotransferase domain. Family members that contain this domain catalyse the conversion of aspartate to asparagine. Asparagine synthetase B catalyzes...; Region: Asn_Synthase_B_C; cd01991 114615012214 Ligand Binding Site [chemical binding]; other site 114615012215 Molecular Tunnel; other site 114615012216 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 114615012217 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 114615012218 NAD(P) binding site [chemical binding]; other site 114615012219 active site 114615012220 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 114615012221 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 114615012222 sugar transferase, PEP-CTERM/EpsH1 system associated; Region: stp1; TIGR03087 114615012223 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 114615012224 MatE; Region: MatE; cl10513 114615012225 M28 Zn-Peptidases; Region: M28_like_3; cd05644 114615012226 Domain of unknown function (DUF2172); Region: DUF2172; pfam09940 114615012227 active site 114615012228 metal binding site [ion binding]; metal-binding site 114615012229 Cupin domain; Region: Cupin_2; cl09118 114615012230 Hypothetical methyltransferase; Region: Methyltransf_13; pfam08421 114615012231 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cl12011 114615012232 C-methyltransferase C-terminal domain; Region: Methyltransf_14; pfam08484 114615012233 extended (e) SDRs; Region: SDR_e; cd08946 114615012234 NAD dependent epimerase/dehydratase family; Region: Epimerase; pfam01370 114615012235 NAD(P) binding site [chemical binding]; other site 114615012236 active site 114615012237 substrate binding site [chemical binding]; other site 114615012238 GlcNAc-PI de-N-acetylase; Region: PIG-L; cl00929 114615012239 G1P_cytidylyltransferase catalyzes the production of CDP-D-Glucose; Region: G1P_cytidylyltransferase; cd02524 114615012240 substrate binding site [chemical binding]; other site 114615012241 Undecaprenyl-phosphate glucose phosphotransferase; Region: WcaJ_sugtrans; TIGR03023 114615012242 Bacterial sugar transferase; Region: Bac_transf; cl00939 114615012243 H-NS histone family; Region: Histone_HNS; pfam00816 114615012244 Domain in histone-like proteins of HNS family; Region: HNS; cl09251 114615012245 Periplasmic protein involved in polysaccharide export, contains SLBB domain of b-grasp fold [Cell wall/membrane/envelope biogenesis]; Region: Wza; COG1596 114615012246 Polysaccharide biosynthesis/export protein; Region: Poly_export; pfam02563 114615012247 Dopa 4,5-dioxygenase family; Region: DOPA_dioxygen; cl01562 114615012248 Predicted amidohydrolase [General function prediction only]; Region: COG0388 114615012249 First nitrilase domain of an uncharacterized subgroup of the nitrilase superfamily (putative class 13 nitrilases); Region: nitrilase_1_R1; cd07578 114615012250 putative active site [active] 114615012251 catalytic triad [active] 114615012252 putative dimer interface [polypeptide binding]; other site 114615012253 Second nitrilase domain of an uncharacterized subgroup of the nitrilase superfamily (putative class 13 nitrilases); Region: nitrilase_1_R2; cd07579 114615012254 Predicted amidohydrolase [General function prediction only]; Region: COG0388 114615012255 putative active site [active] 114615012256 catalytic triad [active] 114615012257 putative dimer interface [polypeptide binding]; other site 114615012258 Acetamidase/Formamidase family; Region: FmdA_AmdA; cl01023 114615012259 urea ABC transporter, ATP-binding protein UrtE; Region: urea_trans_UrtE; TIGR03410 114615012260 LivF (TM1139) is part of the LIV-I bacterial ABC-type two-component transport system that imports neutral, branched-chain amino acids. The E. coli branched-chain amino acid transporter comprises a heterodimer of ABC transporters (LivF and LivG), a...; Region: ABC_TM1139_LivF_branched; cd03224 114615012261 Walker A/P-loop; other site 114615012262 ATP binding site [chemical binding]; other site 114615012263 Q-loop/lid; other site 114615012264 ABC transporter signature motif; other site 114615012265 Walker B; other site 114615012266 D-loop; other site 114615012267 H-loop/switch region; other site 114615012268 urea ABC transporter, ATP-binding protein UrtD; Region: urea_trans_UrtD; TIGR03411 114615012269 The Mj1267/LivG ABC transporter subfamily is involved in the transport of the hydrophobic amino acids leucine, isoleucine and valine. MJ1267 is a branched-chain amino acid transporter with 29% similarity to both the LivF and LivG components of the E...; Region: ABC_Mj1267_LivG_branched; cd03219 114615012270 Walker A/P-loop; other site 114615012271 ATP binding site [chemical binding]; other site 114615012272 Q-loop/lid; other site 114615012273 ABC transporter signature motif; other site 114615012274 Walker B; other site 114615012275 D-loop; other site 114615012276 H-loop/switch region; other site 114615012277 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 114615012278 TM-ABC transporter signature motif; other site 114615012279 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 114615012280 TM-ABC transporter signature motif; other site 114615012281 ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683 114615012282 Periplasmic component (FmdD) of an active transport system for short-chain amides and urea (FmdDEF); Region: PBP1_Amide_Urea_BP_like; cd06356 114615012283 putative ligand binding site [chemical binding]; other site 114615012284 Response regulator with putative antiterminator output domain [Signal transduction mechanisms]; Region: AmiR; COG3707 114615012285 ANTAR domain; Region: ANTAR; cl04297 114615012286 ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683 114615012287 Periplasmic binding domain of amidase (AmiC) that belongs to the type I periplasmic binding fold protein family; Region: PBP1_AmiC; cd06357 114615012288 ligand binding site [chemical binding]; other site 114615012289 regulator interaction site; other site 114615012290 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_9; cd04666 114615012291 nudix motif; other site 114615012292 Tannase and feruloyl esterase; Region: Tannase; pfam07519 114615012293 FMN-dependent oxidoreductase, nitrilotriacetate monooxygenase family; Region: FMN_nitrolo; TIGR03860 114615012294 nitrilotriacetate monoxygenase oxidizes nitrilotriacetate utilizing reduced flavin mononucleotide (FMNH2) and oxygen. The FMNH2 is provided by an NADH:flavin mononucleotide (FMN) oxidorductase that uses NADH to reduce FMN to FMNH2; Region: Nitrilotriacetate_monoxgenase; cd01095 114615012295 active site 114615012296 non-prolyl cis peptide bond; other site 114615012297 Asp/Glu/Hydantoin racemase; Region: Asp_Glu_race; cl00518 114615012298 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cl12011 114615012299 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 114615012300 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 114615012301 ABC transporter, substrate-binding protein, aliphatic sulfonates family; Region: SsuA_fam; TIGR01728 114615012302 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and...; Region: PBPb; cd00134 114615012303 substrate binding pocket [chemical binding]; other site 114615012304 membrane-bound complex binding site; other site 114615012305 hinge residues; other site 114615012306 Nitroreductase-like family 2. A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes, nitrofurans and...; Region: Nitroreductase_2; cd02138 114615012307 putative FMN binding site [chemical binding]; other site 114615012308 O-acetylhomoserine aminocarboxypropyltransferase; Validated; Region: PRK08134 114615012309 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 114615012310 homodimer interface [polypeptide binding]; other site 114615012311 substrate-cofactor binding pocket; other site 114615012312 pyridoxal 5'-phosphate binding site [chemical binding]; other site 114615012313 catalytic residue [active] 114615012314 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 114615012315 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 114615012316 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 114615012317 BA14K-like protein; Region: BA14K; pfam07886 114615012318 Heme/copper-type cytochrome/quinol oxidases, subunit 1 [Energy production and conversion]; Region: CyoB; COG0843 114615012319 Ubiquinol oxidase subunit I. Ubiquinol oxidase, the terminal oxidase in the respiratory chains of aerobic bacteria, is a multi-chain transmembrane protein located in the cell membrane. It catalyzes the reduction of O2 and simultaneously pumps protons...; Region: Ubiquinol_Oxidase_I; cd01662 114615012320 D-pathway; other site 114615012321 Putative ubiquinol binding site [chemical binding]; other site 114615012322 Low-spin heme (heme b) binding site [chemical binding]; other site 114615012323 Putative water exit pathway; other site 114615012324 Binuclear center (heme o3/CuB) [ion binding]; other site 114615012325 K-pathway; other site 114615012326 Putative proton exit pathway; other site 114615012327 short chain dehydrogenase; Provisional; Region: PRK06139 114615012328 classical (c) SDR, subgroup 3; Region: SDR_c3; cd05360 114615012329 putative NAD(P) binding site [chemical binding]; other site 114615012330 active site 114615012331 flagellar hook-associated protein FlgL; Validated; Region: flgL; PRK08913 114615012332 Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669 114615012333 flagellar hook-associated protein FlgK; Region: flgK_ends; TIGR02492 114615012334 flagellar hook-associated protein FlgK; Validated; Region: flgK; PRK08471 114615012335 flagellar hook protein FlgE; Validated; Region: flgE; PRK05682 114615012336 Flagellar basal body protein FlaE; Region: FlaE; pfam07559 114615012337 flagellar basal-body rod protein FlgF; Region: flgF; TIGR02490 114615012338 Flagellar hook capping protein; Region: FlgD; cl04347 114615012339 Flagellar protein FliS; Region: FliS; cl00654 114615012340 flagellar capping protein; Reviewed; Region: fliD; PRK08032 114615012341 Flagellar hook-associated protein 2 C-terminus; Region: FliD_C; pfam07195 114615012342 flagellin; Provisional; Region: PRK12804 114615012343 Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669 114615012344 Bacterial flagellin C-terminal helical region; Region: Flagellin_C; pfam00700 114615012345 RNA polymerase sigma factor; Provisional; Region: PRK12538 114615012346 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 114615012347 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial...; Region: Sigma70_r4; cd06171 114615012348 DNA binding residues [nucleotide binding] 114615012349 Formyltransferase, catalytic core domain; Region: FMT_core; cl00395 114615012350 active site 114615012351 cosubstrate binding site; other site 114615012352 substrate binding site [chemical binding]; other site 114615012353 catalytic site [active] 114615012354 Subfamily of the nitroreductase family that includes BluB protein in Rhodobacter capsulatus is involved in the conversion of cobinamide to cobalamin in Cobalamin (vitamin B12) biosynthesis. Nitroreductases typically reduce their substrates by using NAD(; Region: BluB; cd02145 114615012355 putative FMN binding site [chemical binding]; other site 114615012356 cobyrinic acid a,c-diamide synthase; Validated; Region: PRK01077 114615012357 Type 1 glutamine amidotransferase (GATase1) domain found in Cobyrinic Acid a,c-Diamide Synthase; Region: GATase1_CobB; cd03130 114615012358 CbiD; Region: CbiD; cl00828 114615012359 Tetrapyrrole (Corrin/Porphyrin) Methylases; Region: TP_methylase; cl00304 114615012360 Cobalamin synthesis G C-terminus; Region: CbiG_C; cl12133 114615012361 Tetrapyrrole (Corrin/Porphyrin) Methylases; Region: TP_methylase; cl00304 114615012362 Precorrin-6B methylase 2 [Coenzyme metabolism]; Region: CobL; COG2242 114615012363 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cl12011 114615012364 Precorrin-6x reductase [Coenzyme metabolism]; Region: CobK; COG2099 114615012365 Precorrin-6x reductase CbiJ/CobK; Region: CbiJ; cl00922 114615012366 Tetrapyrrole (Corrin/Porphyrin) Methylases; Region: TP_methylase; cl00304 114615012367 Tetrapyrrole (Corrin/Porphyrin) Methylases; Region: TP_methylase; cl00304 114615012368 Precorrin isomerase [Coenzyme metabolism]; Region: CobH; cl00913 114615012369 Precorrin-8X methylmutase; Region: CbiC; pfam02570 114615012370 precorrin-3B synthase; Region: CobG; TIGR02435 114615012371 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 114615012372 cobaltochelatase subunit CobN; Reviewed; Region: cobN; PRK12321 114615012373 cobalamin biosynthesis protein CobW; Region: CobW; TIGR02475 114615012374 Ras-like GTPase superfamily. The Ras-like superfamily of small GTPases consists of several families with an extremely high degree of structural and functional similarity. The Ras superfamily is divided into at least four families in eukaryotes: the Ras...; Region: Ras_like_GTPase; cl10444 114615012375 Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; cl08458 114615012376 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 114615012377 HupE / UreJ protein; Region: HupE_UreJ; cl01011 114615012378 Adenosylcobinamide kinase / adenosylcobinamide phosphate guanyltransferase (CobU). CobU is bifunctional cobalbumin biosynthesis enzymes which display adenosylcobinamide kinase and adenosylcobinamide phosphate guanyltransferase activity. This enzyme is...; Region: CobU; cd00544 114615012379 homotrimer interface [polypeptide binding]; other site 114615012380 Walker A motif; other site 114615012381 GTP binding site [chemical binding]; other site 114615012382 Walker B motif; other site 114615012383 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 114615012384 ATP:corrinoid adenosyltransferase [Coenzyme metabolism]; Region: BtuR; COG2109 114615012385 ATP:corrinoid adenosyltransferase BtuR/CobO/CobP. This family consists of the BtuR, CobO, CobP proteins all of which are Cob(I)alamin (vitamin B12) adenosyltransferase, which is involved in cobalamin (vitamin B12) biosynthesis. This enzyme is a...; Region: CobA_CobO_BtuR; cd00561 114615012386 homodimer interface [polypeptide binding]; other site 114615012387 Walker A motif; other site 114615012388 ATP binding site [chemical binding]; other site 114615012389 hydroxycobalamin binding site [chemical binding]; other site 114615012390 Walker B motif; other site 114615012391 cobyric acid synthase; Provisional; Region: PRK00784 114615012392 Type 1 glutamine amidotransferase (GATase1) domain found in Cobyric Acid Synthase (CobQ); Region: GATase1_CobQ; cd01750 114615012393 catalytic triad [active] 114615012394 CobD/Cbib protein; Region: CobD_Cbib; cl00561 114615012395 Histidinol-phosphate/aromatic aminotransferase and cobyric acid decarboxylase [Amino acid transport and metabolism]; Region: HisC; COG0079 114615012396 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 114615012397 pyridoxal 5'-phosphate binding site [chemical binding]; other site 114615012398 homodimer interface [polypeptide binding]; other site 114615012399 catalytic residue [active] 114615012400 Cobalamin-5-phosphate synthase; Region: CobS; cl00415 114615012401 Histidine phosphatase domain found in a functionally diverse set of proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP; cd07040 114615012402 Histidine phosphatase superfamily (branch 1); Region: His_Phos_1; pfam00300 114615012403 catalytic core [active] 114615012404 Phosphoribosyltransferase; Region: DBI_PRT; pfam02277 114615012405 Nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase (DMB-PRT), also called CobT; Region: DMB-PRT_CobT; cd02439 114615012406 putative dimer interface [polypeptide binding]; other site 114615012407 active site pocket [active] 114615012408 putative cataytic base [active] 114615012409 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cl09944 114615012410 ornithine decarboxylase; Provisional; Region: PRK13578 114615012411 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 114615012412 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 114615012413 catalytic residue [active] 114615012414 Orn/Lys/Arg decarboxylase, C-terminal domain; Region: OKR_DC_1_C; pfam03711 114615012415 Sortase and related acyltransferases [Cell envelope biogenesis, outer membrane]; Region: COG1247 114615012416 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 114615012417 Coenzyme A binding pocket [chemical binding]; other site 114615012418 Phosphoglycerate dehydrogenase and related dehydrogenases [Amino acid transport and metabolism]; Region: SerA; COG0111 114615012419 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 114615012420 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 114615012421 PYR/PP interface [polypeptide binding]; other site 114615012422 dimer interface [polypeptide binding]; other site 114615012423 TPP binding site [chemical binding]; other site 114615012424 hypothetical protein; Provisional; Region: PRK06163 114615012425 TPP-binding module; composed of proteins similar to Methanococcus jannaschii sulfopyruvate decarboxylase beta subunit (ComE). M. jannaschii sulfopyruvate decarboxylase (ComDE) is a dodecamer of six alpha (D) subunits and six (E) beta subunits, which...; Region: TPP_ComE; cd03372 114615012426 TPP-binding site; other site 114615012427 Protein of unknown function (DUF1236); Region: DUF1236; pfam06823 114615012428 lysyl-tRNA synthetase; Provisional; Region: lysS; PRK02983 114615012429 GST_N family, Saccharomyces cerevisiae GTT1-like subfamily; composed of predominantly uncharacterized proteins with similarity to the S. cerevisiae GST protein, GTT1, and the Schizosaccharomyces pombe GST-III. GSTs are cytosolic dimeric proteins...; Region: GST_N_GTT1_like; cd03046 114615012430 putative C-terminal domain interface [polypeptide binding]; other site 114615012431 putative GSH binding site (G-site) [chemical binding]; other site 114615012432 putative dimer interface [polypeptide binding]; other site 114615012433 C-terminal, alpha helical domain of the Glutathione S-transferase family; Region: GST_C_family; cl02776 114615012434 4-hydroxyphenylacetate permease; Region: HpaX; TIGR02332 114615012435 FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790 114615012436 stage V sporulation protein K; Region: spore_V_K; TIGR02881 114615012437 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes...; Region: AAA; cd00009 114615012438 Walker A motif; other site 114615012439 ATP binding site [chemical binding]; other site 114615012440 Walker B motif; other site 114615012441 arginine finger; other site 114615012442 stage V sporulation protein K; Region: spore_V_K; TIGR02881 114615012443 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes...; Region: AAA; cd00009 114615012444 Walker A motif; other site 114615012445 ATP binding site [chemical binding]; other site 114615012446 Walker B motif; other site 114615012447 arginine finger; other site 114615012448 Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic...; Region: Tryp_SPc; cl00149 114615012449 hydroxypyruvate isomerase; Region: OH-pyruv-isom; TIGR03234 114615012450 glyoxylate carboligase; Provisional; Region: PRK11269 114615012451 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 114615012452 PYR/PP interface [polypeptide binding]; other site 114615012453 dimer interface [polypeptide binding]; other site 114615012454 TPP binding site [chemical binding]; other site 114615012455 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 114615012456 Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin...; Region: TPP_enzymes; cl01629 114615012457 TPP-binding site [chemical binding]; other site 114615012458 Adenine deaminase [Nucleotide transport and metabolism]; Region: AdeC; COG1001 114615012459 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have...; Region: metallo-dependent_hydrolases; cl00281 114615012460 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have...; Region: metallo-dependent_hydrolases; cl00281 114615012461 active site 114615012462 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have...; Region: metallo-dependent_hydrolases; cl00281 114615012463 transcriptional repressor IclR; Provisional; Region: PRK11569 114615012464 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 114615012465 Bacterial transcriptional regulator; Region: IclR; pfam01614 114615012466 Acyl-CoA synthetase (NDP forming) [Energy production and conversion]; Region: COG1042 114615012467 acetyl coenzyme A synthetase (ADP forming), alpha domain; Region: AcCoA-syn-alpha; TIGR02717 114615012468 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 114615012469 Transcriptional regulators [Transcription]; Region: GntR; COG1802 114615012470 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 114615012471 DNA-binding site [nucleotide binding]; DNA binding site 114615012472 FCD domain; Region: FCD; cl11656 114615012473 putative oxalyl-CoA decarboxylase; Validated; Region: PRK09259 114615012474 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 114615012475 PYR/PP interface [polypeptide binding]; other site 114615012476 dimer interface [polypeptide binding]; other site 114615012477 TPP binding site [chemical binding]; other site 114615012478 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 114615012479 TPP-binding module; composed of proteins similar to benzaldehyde lyase (BZL), oxalyl-CoA decarboxylase (OCoD) and 2-hydroxyphytanoyl-CoA lyase (2-HPCL). Pseudomonas fluorescens biovar I BZL cleaves the acyloin linkage of benzoin producing 2 molecules...; Region: TPP_BZL_OCoD_HPCL; cd02004 114615012480 TPP-binding site; other site 114615012481 dimer interface [polypeptide binding]; other site 114615012482 CoA-transferase family III; Region: CoA_transf_3; cl00778 114615012483 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 114615012484 Uncharacterized membrane-anchored protein conserved in bacteria [Function unknown]; Region: COG4705 114615012485 Repeat of Unknown Function (DUF347); Region: DUF347; pfam03988 114615012486 Oxalate/Formate Antiporter; Region: 2A0111; TIGR00890 114615012487 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 114615012488 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 114615012489 putative substrate translocation pore; other site 114615012490 Oxalate/Formate Antiporter; Region: 2A0111; TIGR00890 114615012491 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 114615012492 putative substrate translocation pore; other site 114615012493 FOG: CBS domain [General function prediction only]; Region: COG0517 114615012494 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-...; Region: CBS_pair_10; cd04623 114615012495 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl14614 114615012496 putative NAD(P)H quinone oxidoreductase, PIG3 family; Region: quinone_pig3; TIGR02824 114615012497 NAD(P) binding site [chemical binding]; other site 114615012498 Cation efflux family; Region: Cation_efflux; cl00316 114615012499 Cation efflux family; Region: Cation_efflux; cl00316 114615012500 Cation efflux family; Region: Cation_efflux; cl00316 114615012501 putative diguanylate cyclase; Provisional; Region: PRK09776 114615012502 Motif C-terminal to PAS motifs (likely to contribute to PAS structural domain); Region: PAC; smart00086 114615012503 PAS fold; Region: PAS_7; pfam12860 114615012504 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via trans-...; Region: HisKA; cd00082 114615012505 dimer interface [polypeptide binding]; other site 114615012506 phosphorylation site [posttranslational modification] 114615012507 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 114615012508 ATP binding site [chemical binding]; other site 114615012509 Mg2+ binding site [ion binding]; other site 114615012510 G-X-G motif; other site 114615012511 Transposase domain (DUF772); Region: DUF772; cl12084 114615012512 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 114615012513 YeeE/YedE family (DUF395); Region: DUF395; cl01018 114615012514 putative inner membrane protein; Provisional; Region: PRK11099 114615012515 Transcriptional regulator [Transcription]; Region: LysR; COG0583 114615012516 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 114615012517 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 114615012518 dimerization interface [polypeptide binding]; other site 114615012519 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 114615012520 TRX-like [2Fe-2S] Ferredoxin (Fd) family, NAD-dependent formate dehydrogenase (FDH) beta subunit; composed of proteins similar to the beta subunit of NAD-linked FDH of Ralstonia eutropha, a soluble enzyme that catalyzes the irreversible oxidation of...; Region: TRX_Fd_FDH_beta; cd03063 114615012521 putative dimer interface [polypeptide binding]; other site 114615012522 NADH:ubiquinone oxidoreductase, NADH-binding (51 kD) subunit [Energy production and conversion]; Region: NuoF; COG1894 114615012523 Respiratory-chain NADH dehydrogenase 51 Kd subunit; Region: Complex1_51K; pfam01512 114615012524 SLBB domain; Region: SLBB; pfam10531 114615012525 NADH-ubiquinone oxidoreductase-F iron-sulfur binding region; Region: NADH_4Fe-4S; cl11211 114615012526 Uncharacterized anaerobic dehydrogenase [General function prediction only]; Region: COG3383 114615012527 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 114615012528 catalytic loop [active] 114615012529 iron binding site [ion binding]; other site 114615012530 NADH-ubiquinone oxidoreductase-G iron-sulfur binding region; Region: NADH-G_4Fe-4S_3; cl11210 114615012531 Formate dehydrogenase H (Formate-Dh-H) catalyzes the reversible oxidation of formate to CO2 with the release of a proton and two electrons. It is a component of the anaerobic formate hydrogen lyase complex. The E. coli formate dehydrogenase H (Fdh-H)...; Region: MopB_Formate-Dh-H; cd02753 114615012532 [4Fe-4S] binding site [ion binding]; other site 114615012533 molybdopterin cofactor binding site; other site 114615012534 This CD includes formate dehydrogenases (Fdh) H and N; nitrate reductases, Nap and Nas; and other related proteins. Formate dehydrogenase H is a component of the anaerobic formate hydrogen lyase complex and catalyzes the reversible oxidation of...; Region: MopB_CT_Fdh-Nap-like; cd00508 114615012535 molybdopterin cofactor binding site; other site 114615012536 FdhD/NarQ family; Region: FdhD-NarQ; cl00659 114615012537 NADH-dependant formate dehydrogenase delta subunit FdsD; Region: FdsD; pfam11390 114615012538 Ion transport protein; Region: Ion_trans; pfam00520 114615012539 Ion channel; Region: Ion_trans_2; cl11596 114615012540 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 114615012541 ligand binding site [chemical binding]; other site 114615012542 flexible hinge region; other site 114615012543 alanyl-tRNA synthetase; Reviewed; Region: alaS; PRK00252 114615012544 Alanyl-tRNA synthetase (AlaRS) class II core catalytic domain. AlaRS is a homodimer. It is responsible for the attachment of alanine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent formation...; Region: AlaRS_core; cd00673 114615012545 motif 1; other site 114615012546 active site 114615012547 motif 2; other site 114615012548 motif 3; other site 114615012549 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; cl08469 114615012550 glycine cleavage system aminomethyltransferase T; Provisional; Region: gcvT; PRK13579 114615012551 Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669 114615012552 Glycine cleavage H-protein. Glycine cleavage H-proteins are part of the glycine cleavage system (GCS) found in bacteria, archea and the mitochondria of eukaryotes. GCS is a multienzyme complex consisting of 4 different components (P-, H-, T- and L-...; Region: GCS_H; cd06848 114615012553 lipoyl attachment site [posttranslational modification]; other site 114615012554 glycine dehydrogenase; Provisional; Region: PRK05367 114615012555 Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2...; Region: GDC-P; cd00613 114615012556 tetramer interface [polypeptide binding]; other site 114615012557 pyridoxal 5'-phosphate binding site [chemical binding]; other site 114615012558 catalytic residue [active] 114615012559 Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2...; Region: GDC-P; cd00613 114615012560 tetramer interface [polypeptide binding]; other site 114615012561 pyridoxal 5'-phosphate binding site [chemical binding]; other site 114615012562 catalytic residue [active] 114615012563 recombinase A; Provisional; Region: recA; PRK09354 114615012564 RecA is a bacterial enzyme which has roles in homologous recombination, DNA repair, and the induction of the SOS response. RecA couples ATP hydrolysis to DNA strand exchange; Region: recA; cd00983 114615012565 hexamer interface [polypeptide binding]; other site 114615012566 Walker A motif; other site 114615012567 ATP binding site [chemical binding]; other site 114615012568 Walker B motif; other site 114615012569 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 114615012570 CoenzymeA binding site [chemical binding]; other site 114615012571 subunit interaction site [polypeptide binding]; other site 114615012572 PHB binding site; other site 114615012573 PilZ domain; Region: PilZ; cl01260 114615012574 Caspase, interleukin-1 beta converting enzyme (ICE) homologues; Cysteine-dependent aspartate-directed proteases that mediate programmed cell death (apoptosis). Caspases are synthesized as inactive zymogens and activated by proteolysis of the peptide...; Region: CASc; cl00042 114615012575 substrate pocket [chemical binding]; other site 114615012576 active site 114615012577 dimer interface [polypeptide binding]; other site 114615012578 proteolytic cleavage site; other site 114615012579 Response regulator containing a CheY-like receiver domain and an HD-GYP domain [Transcription / Signal transduction mechanisms]; Region: COG3437 114615012580 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 114615012581 Zn2+ binding site [ion binding]; other site 114615012582 Mg2+ binding site [ion binding]; other site 114615012583 Protein involved in cellulose biosynthesis (CelD) [Cell envelope biogenesis, outer membrane]; Region: COG5653 114615012584 Predicted dithiol-disulfide isomerase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: FrnE; COG2761 114615012585 DsbA family, FrnE subfamily; FrnE is a DsbA-like protein containing a CXXC motif. It is presumed to be a thiol oxidoreductase involved in polyketide biosynthesis, specifically in the production of the aromatic antibiotics frenolicin and nanaomycins; Region: DsbA_FrnE; cd03024 114615012586 catalytic residues [active] 114615012587 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 114615012588 non-specific DNA binding site [nucleotide binding]; other site 114615012589 salt bridge; other site 114615012590 sequence-specific DNA binding site [nucleotide binding]; other site 114615012591 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cd02440 114615012592 S-adenosylmethionine binding site [chemical binding]; other site 114615012593 SET domain; Region: SET; cl02566 114615012594 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 114615012595 Lignostilbene-alpha,beta-dioxygenase and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3670 114615012596 Retinal pigment epithelial membrane protein; Region: RPE65; cl10080 114615012597 Protein of unknown function (DUF429); Region: DUF429; cl12046 114615012598 YdeM is a Bacillus subtilis protein that belongs to a family of prokaryotic proteins of unkown function. YdeM has sequence similarity to the hot-dog fold of (R)-specific enoyl-CoA hydratase. Other enzymes with this fold include the peroxisomal...; Region: YdeM; cd03454 114615012599 putative active site [active] 114615012600 putative catalytic site [active] 114615012601 fumarate hydratase; Provisional; Region: PRK15389 114615012602 Fumarate hydratase (Fumerase); Region: Fumerase; cl00851 114615012603 Fumarase C-terminus; Region: Fumerase_C; cl00795 114615012604 GST_N family, Class Sigma_like; composed of GSTs belonging to class Sigma and similar proteins, including GSTs from class Mu, Pi and Alpha. GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of...; Region: GST_N_Sigma_like; cd03039 114615012605 glutathione s-transferase; Provisional; Region: PTZ00057 114615012606 GSH binding site (G-site) [chemical binding]; other site 114615012607 C-terminal domain interface [polypeptide binding]; other site 114615012608 dimer interface [polypeptide binding]; other site 114615012609 C-terminal, alpha helical domain of Class Sigma-like Glutathione S-transferases; Region: GST_C_Sigma_like; cd03192 114615012610 dimer interface [polypeptide binding]; other site 114615012611 N-terminal domain interface [polypeptide binding]; other site 114615012612 substrate binding pocket (H-site) [chemical binding]; other site 114615012613 Tim44-like domain; Region: Tim44; cl09208 114615012614 PAS fold; Region: PAS_4; pfam08448 114615012615 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 114615012616 putative active site [active] 114615012617 heme pocket [chemical binding]; other site 114615012618 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 114615012619 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via trans-...; Region: HisKA; cd00082 114615012620 dimer interface [polypeptide binding]; other site 114615012621 phosphorylation site [posttranslational modification] 114615012622 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 114615012623 ATP binding site [chemical binding]; other site 114615012624 Mg2+ binding site [ion binding]; other site 114615012625 G-X-G motif; other site 114615012626 Response regulator receiver domain; Region: Response_reg; pfam00072 114615012627 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156 114615012628 active site 114615012629 phosphorylation site [posttranslational modification] 114615012630 intermolecular recognition site; other site 114615012631 dimerization interface [polypeptide binding]; other site 114615012632 flagellar biosynthesis protein FlhB; Reviewed; Region: flhB; PRK05702 114615012633 Flagellar biosynthesis pathway, component FlhB [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FlhB; cl12017 114615012634 Bacterial export proteins, family 1; Region: Bac_export_1; cl00734 114615012635 Bacterial export proteins, family 3; Region: Bac_export_3; cl00867 114615012636 Flagellar hook-basal body complex protein FliE; Region: FliE; cl09139 114615012637 flagellar basal body rod protein FlgC; Reviewed; Region: flgC; PRK05681 114615012638 Domain of unknown function (DUF1078); Region: DUF1078; pfam06429 114615012639 flagellar basal body rod protein FlgB; Reviewed; Region: flgB; PRK06004 114615012640 FliP family; Region: FliP; cl00593 114615012641 Peptidase S46; Region: Peptidase_S46; pfam10459 114615012642 MgtE intracellular N domain; Region: MgtE_N; cl15244 114615012643 flagellar motor switch protein FliM; Reviewed; Region: fliM; PRK12795 114615012644 Surface presentation of antigens (SPOA); Region: SpoA; cl00819 114615012645 Flagellar basal body-associated protein FliL; Region: FliL; cl00681 114615012646 flagellar basal body rod protein FlgF; Reviewed; Region: flgF; PRK12689 114615012647 flagellar basal-body rod protein FlgF; Region: flgF; TIGR02490 114615012648 flagellar basal body rod protein FlgG; Reviewed; Region: flgG; PRK12691 114615012649 Flagella basal body rod protein; Region: Flg_bb_rod; cl15245 114615012650 flagellar basal-body rod protein FlgF; Region: flgF; TIGR02490 114615012651 flagellar basal body P-ring biosynthesis protein FlgA; Reviewed; Region: flgA; PRK12786 114615012652 SAF domain; Region: SAF; cl00555 114615012653 Flagellar L-ring protein; Region: FlgH; cl00905 114615012654 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; cl11421 114615012655 hopanoid-associated sugar epimerase; Region: HpnA; TIGR03466 114615012656 aldehyde reductase, extended (e) SDRs; Region: AR_SDR_e; cd05227 114615012657 NADP binding site [chemical binding]; other site 114615012658 putative substrate binding site [chemical binding]; other site 114615012659 active site 114615012660 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 114615012661 PAS fold; Region: PAS_3; pfam08447 114615012662 putative active site [active] 114615012663 heme pocket [chemical binding]; other site 114615012664 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920 114615012665 Histidine kinase; Region: HisKA_2; cl06527 114615012666 Prokaryotic dksA/traR C4-type zinc finger; Region: zf-dskA_traR; cl00755 114615012667 biliverdin IX beta reductase (BVR-B, aka flavin reductase)-like proteins; atypical (a) SDRs; Region: BVR-B_like_SDR_a; cd05244 114615012668 NAD binding site [chemical binding]; other site 114615012669 putative active site [active] 114615012670 substrate binding site [chemical binding]; other site 114615012671 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 114615012672 Class II flagellar assembly regulator; Region: FliX; cl11677 114615012673 flagellar basal body P-ring protein; Provisional; Region: flgI; PRK05303 114615012674 flagellar basal body P-ring protein; Reviewed; Region: flgI; cl14622 114615012675 Rod binding protein; Region: Rod-binding; cl01626 114615012676 Flagellar protein FlaF; Region: FlaF; cl11454 114615012677 flagellin; Reviewed; Region: PRK12688 114615012678 flagellin; Reviewed; Region: PRK12688 114615012679 flagellin; Reviewed; Region: PRK12688 114615012680 Flagellar protein FlbT; Region: FlbT; cl11455 114615012681 flagellin; Reviewed; Region: PRK12688 114615012682 flagellin; Reviewed; Region: PRK12688 114615012683 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 114615012684 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 114615012685 catalytic residue [active] 114615012686 Glutathione synthase/Ribosomal protein S6 modification enzyme (glutaminyl transferase) [Coenzyme metabolism / Translation, ribosomal structure and biogenesis]; Region: RimK; COG0189 114615012687 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl14614 114615012688 flagellar hook-associated protein FlgL; Validated; Region: flgL; PRK07701 114615012689 flagellin; Provisional; Region: PRK14708 114615012690 flagellar hook-associated protein FlgL; Validated; Region: flgL; PRK06008 114615012691 flagellar hook-associated protein FlgK; Region: flgK_ends; TIGR02492 114615012692 Flagella basal body rod protein; Region: Flg_bb_rod; cl15245 114615012693 flagellar hook-associated protein FlgK; Validated; Region: flgK; PRK07521 114615012694 Domain of unknown function (DUF1078); Region: DUF1078; pfam06429 114615012695 fagellar hook-basal body proteins; Region: FlgEFG_subfam; TIGR03506 114615012696 flagellar hook protein FlgE; Validated; Region: flgE; PRK06803 114615012697 Flagellar basal body protein FlaE; Region: FlaE; pfam07559 114615012698 Domain of unknown function (DUF1078); Region: DUF1078; pfam06429 114615012699 SelR domain; Region: SelR; cl00369 114615012700 Malate:quinone oxidoreductase (Mqo); Region: Mqo; cl14881 114615012701 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 114615012702 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 114615012703 catalytic core [active] 114615012704 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 114615012705 Ligand Binding Site [chemical binding]; other site 114615012706 Transposase domain (DUF772); Region: DUF772; cl12084 114615012707 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 114615012708 YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259 114615012709 putative active site [active] 114615012710 YciF bacterial stress response protein, ferritin-like iron-binding domain; Region: YciF; cd07909 114615012711 dimerization interface [polypeptide binding]; other site 114615012712 metal binding site [ion binding]; metal-binding site 114615012713 Uncharacterised protein family (UPF0104); Region: UPF0104; cl04219 114615012714 SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cl01053 114615012715 active site 114615012716 oxyanion hole [active] 114615012717 Uncharacterized protein conserved in bacteria (DUF2147); Region: DUF2147; cl01951 114615012718 Thioredoxin reductase [Posttranslational modification, protein turnover, chaperones]; Region: TrxB; COG0492 114615012719 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 114615012720 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 114615012721 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active...; Region: 4HBT; cd00586 114615012722 active site 114615012723 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cl00159 114615012724 gp58-like protein; Region: Gp58; pfam07902 114615012725 ABC-type transport system involved in resistance to organic solvents, periplasmic component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2C; COG1463 114615012726 mce related protein; Region: MCE; pfam02470 114615012727 ABC-type transport system involved in resistance to organic solvents, ATPase component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2A; COG1127 114615012728 ABC (ATP-binding cassette) transport system involved in resistant to organic solvents; ABC transporters are a large family of proteins involved in the transport of a wide variety of different compounds, like sugars, ions, peptides, and more complex...; Region: ABC_Org_Solvent_Resistant; cd03261 114615012729 Walker A/P-loop; other site 114615012730 ATP binding site [chemical binding]; other site 114615012731 Q-loop/lid; other site 114615012732 ABC transporter signature motif; other site 114615012733 Walker B; other site 114615012734 D-loop; other site 114615012735 H-loop/switch region; other site 114615012736 Domain of unknown function DUF140; Region: DUF140; cl00510 114615012737 L-Ala-D/L-Glu epimerase catalyzes the epimerization of L-Ala-D/L-Glu and other dipeptides. The genomic context and the substrate specificity of characterized members of this family from E.coli and B.subtilis indicates a possible role in the metabolism...; Region: L-Ala-DL-Glu_epimerase; cd03319 114615012738 L-Ala-D/L-Glu epimerase; Provisional; Region: PRK15129 114615012739 active site 114615012740 putative 3-phenylpropionic acid transporter; Provisional; Region: PRK11128 114615012741 Caspase, interleukin-1 beta converting enzyme (ICE) homologues; Cysteine-dependent aspartate-directed proteases that mediate programmed cell death (apoptosis). Caspases are synthesized as inactive zymogens and activated by proteolysis of the peptide...; Region: CASc; cl00042 114615012742 substrate pocket [chemical binding]; other site 114615012743 active site 114615012744 proteolytic cleavage site; other site 114615012745 dimer interface [polypeptide binding]; other site 114615012746 serine/threonine dehydratase; Validated; Region: PRK07048 114615012747 Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562 114615012748 tetramer interface [polypeptide binding]; other site 114615012749 pyridoxal 5'-phosphate binding site [chemical binding]; other site 114615012750 catalytic residue [active] 114615012751 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 114615012752 Escherichia coli YbbF/LpxH and related proteins, metallophosphatase domain; Region: MPP_YbbF-LpxH; cd07398 114615012753 putative active site [active] 114615012754 putative metal binding site [ion binding]; other site 114615012755 pyruvate kinase; Provisional; Region: PRK06247 114615012756 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl09155 114615012757 domain interfaces; other site 114615012758 active site 114615012759 Isocitrate/isopropylmalate dehydrogenase; Region: Iso_dh; cl00445 114615012760 isocitrate dehydrogenase; Validated; Region: PRK06451 114615012761 DNA-binding transcriptional regulator HcaR; Provisional; Region: PRK09906 114615012762 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 114615012763 The C-terminal substrate binding domain of LysR-type transcriptional regulators involved in the catabolism of aromatic compounds and that of other related regulators, contains type 2 periplasmic binding fold; Region: PBP2_LTTR_aromatics_like; cd08414 114615012764 dimerization interface [polypeptide binding]; other site 114615012765 substrate binding pocket [chemical binding]; other site 114615012766 glycogen debranching enzyme GlgX; Region: glgX_debranch; TIGR02100 114615012767 Glycogen_debranching_enzyme N-terminal domain. Glycogen debranching enzymes have both 4-alpha-glucanotransferase and amylo-1,6-glucosidase activities. As a transferase it transfers a segment of a 1,4-alpha-D-glucan to a new 4-position in an acceptor...; Region: Glycogen_debranching_enzyme_N_term; cd02856 114615012768 Alpha amylase, catalytic domain; Region: Alpha-amylase; cl07893 114615012769 Protein of unknown function (DUF3606); Region: DUF3606; pfam12244 114615012770 Protein of unknown function (DUF3551); Region: DUF3551; pfam12071 114615012771 sensor protein PhoQ; Provisional; Region: PRK10815 114615012772 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 114615012773 ATP binding site [chemical binding]; other site 114615012774 Mg2+ binding site [ion binding]; other site 114615012775 G-X-G motif; other site 114615012776 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 114615012777 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156 114615012778 active site 114615012779 phosphorylation site [posttranslational modification] 114615012780 intermolecular recognition site; other site 114615012781 dimerization interface [polypeptide binding]; other site 114615012782 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase...; Region: trans_reg_C; cd00383 114615012783 DNA binding site [nucleotide binding] 114615012784 Peptidase propeptide and YPEB domain; Region: PepSY; pfam03413 114615012785 Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane channels that selectively transport water, small neutral molecules, and ions out of and between cells. The channel proteins share a common fold: the N-...; Region: MIP; cl00200 114615012786 Low molecular weight phosphatase family; Region: LMWPc; cd00115 114615012787 Active site [active] 114615012788 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 114615012789 dimerization interface [polypeptide binding]; other site 114615012790 putative DNA binding site [nucleotide binding]; other site 114615012791 putative Zn2+ binding site [ion binding]; other site 114615012792 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 114615012793 dimerization interface [polypeptide binding]; other site 114615012794 putative DNA binding site [nucleotide binding]; other site 114615012795 putative Zn2+ binding site [ion binding]; other site 114615012796 Major Facilitator Superfamily; Region: MFS_1; pfam07690 114615012797 Predicted signal transduction protein containing sensor and EAL domains [Signal transduction mechanisms]; Region: COG4943 114615012798 CSS motif domain associated with EAL; Region: CSS-motif; pfam12792 114615012799 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 114615012800 CHRD domain; Region: CHRD; cl06473 114615012801 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 114615012802 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 114615012803 Transcriptional regulators [Transcription]; Region: GntR; COG1802 114615012804 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 114615012805 DNA-binding site [nucleotide binding]; DNA binding site 114615012806 FCD domain; Region: FCD; cl11656 114615012807 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 114615012808 active site 114615012809 metal binding site [ion binding]; metal-binding site 114615012810 3,4-dihydroxyphenylacetate 2,3-dioxygenase; Region: HpaD; TIGR02295 114615012811 C-terminal, catalytic, domain of BphC5 (2,3-dihydroxybiphenyl 1,2-dioxygenase) from Bacterium Rhodococcus rhodochrous K37 and similar proteins; Region: BphC5-RK37_C_like; cd07239 114615012812 putative active site [active] 114615012813 Mn binding site [ion binding]; other site 114615012814 putative oligomer interface [polypeptide binding]; other site 114615012815 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 114615012816 3-(3-hydroxyphenyl)propionate hydroxylase; Validated; Region: mhpA; PRK06183 114615012817 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 114615012818 D-galactonate transporter; Region: 2A0114; TIGR00893 114615012819 putative substrate translocation pore; other site 114615012820 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; cl11421 114615012821 Transposase domain (DUF772); Region: DUF772; cl12084 114615012822 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 114615012823 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 114615012824 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 114615012825 putative substrate translocation pore; other site 114615012826 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 114615012827 Multidrug resistance efflux pump [Defense mechanisms]; Region: EmrA; COG1566 114615012828 Protein of unknown function (DUF1275); Region: DUF1275; cl01453 114615012829 DoxX; Region: DoxX; cl00976 114615012830 Predicted metal-dependent hydrolase with the TIM-barrel fold [General function prediction only]; Region: COG1574 114615012831 YtcJ_like metal dependent amidohydrolases. YtcJ is a Bacillus subtilis ORF of unknown function. The Arabidopsis homolog LAF3 has been identified as a factor required for photochrome A signalling; Region: YtcJ_like; cd01300 114615012832 active site 114615012833 Protein of unknown function (DUF1427); Region: DUF1427; cl01771 114615012834 Isochorismatase family; Region: Isochorismatase; pfam00857 114615012835 YcaC related amidohydrolases; E.coli YcaC is an homooctameric hydrolase with unknown specificity. Despite its weak sequence similarity, it is structurally related to other amidohydrolases and shares conserved active site residues with them...; Region: YcaC_related; cd01012 114615012836 catalytic triad [active] 114615012837 dimer interface [polypeptide binding]; other site 114615012838 conserved cis-peptide bond; other site 114615012839 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 114615012840 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 114615012841 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 114615012842 Arabinose-binding domain of AraC transcription regulator, N-term; Region: Arabinose_bd; pfam12625 114615012843 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl09108 114615012844 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 114615012845 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 114615012846 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109 114615012847 bifunctional hydroxy-methylpyrimidine kinase/ hydroxy-phosphomethylpyrimidine kinase; Reviewed; Region: PRK06427 114615012848 4-amino-5-hydroxymethyl-2-methyl-pyrimidine phosphate kinase (HMPP-kinase) catalyzes two consecutive phosphorylation steps in the thiamine phosphate biosynthesis pathway, leading to the synthesis of vitamin B1. The first step is the phosphorylation of...; Region: HMPP_kinase; cd01169 114615012849 dimer interface [polypeptide binding]; other site 114615012850 substrate binding site [chemical binding]; other site 114615012851 ATP binding site [chemical binding]; other site 114615012852 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 114615012853 DNA-binding transcriptional activator FeaR; Provisional; Region: PRK09685 114615012854 CHASE domain; Region: CHASE; cl01369 114615012855 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 114615012856 metal binding site [ion binding]; metal-binding site 114615012857 active site 114615012858 I-site; other site 114615012859 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 114615012860 ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683 114615012861 Type I periplasmic binding domain of uncharacterized extracellular ligand-binding proteins; Region: PBP1_STKc_like; cd06326 114615012862 putative ligand binding site [chemical binding]; other site 114615012863 Cytochrome c; Region: Cytochrom_C; cl11414 114615012864 Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010 114615012865 Cytochrome c; Region: Cytochrom_C; cl11414 114615012866 Cytochrome C'; Region: Cytochrom_C_2; cl01610 114615012867 Aerobic-type carbon monoxide dehydrogenase, large subunit CoxL/CutL homologs [Energy production and conversion]; Region: CoxL; COG1529 114615012868 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; cl03161 114615012869 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 114615012870 Reeler-like domain of YcnI and similar proteins; Region: YcnI_like; cd08545 114615012871 Protein of unknown function (DUF461); Region: DUF461; cl01071 114615012872 TonB-dependent siderophore receptor; Region: TonB-siderophor; TIGR01783 114615012873 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 114615012874 N-terminal plug; other site 114615012875 ligand-binding site [chemical binding]; other site 114615012876 Uncharacterized membrane protein, putative virulence factor [General function prediction only]; Region: MviN; COG0728 114615012877 Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WecE; COG0399 114615012878 3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616 114615012879 inhibitor-cofactor binding pocket; inhibition site 114615012880 pyridoxal 5'-phosphate binding site [chemical binding]; other site 114615012881 catalytic residue [active] 114615012882 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 114615012883 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 114615012884 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; cl11611 114615012885 Protein of unknown function (DUF1223); Region: DUF1223; cl10501 114615012886 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi...; Region: TPR; cd00189 114615012887 binding surface 114615012888 TPR motif; other site 114615012889 Predicted O-linked N-acetylglucosamine transferase, SPINDLY family [Posttranslational modification, protein turnover, chaperones]; Region: Spy; COG3914 114615012890 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi...; Region: TPR; cd00189 114615012891 binding surface 114615012892 TPR motif; other site 114615012893 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi...; Region: TPR; cd00189 114615012894 binding surface 114615012895 TPR motif; other site 114615012896 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi...; Region: TPR; cd00189 114615012897 binding surface 114615012898 TPR motif; other site 114615012899 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi...; Region: TPR; cd00189 114615012900 binding surface 114615012901 TPR motif; other site 114615012902 Predicted O-linked N-acetylglucosamine transferase, SPINDLY family [Posttranslational modification, protein turnover, chaperones]; Region: Spy; COG3914 114615012903 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi...; Region: TPR; cd00189 114615012904 binding surface 114615012905 TPR motif; other site 114615012906 mannose-1-phosphate guanylyltransferase/mannose-6-phosphate isomerase; Region: GMP_PMI; TIGR01479 114615012907 GDP-M1P_Guanylyltransferase catalyzes the formation of GDP-Mannose; Region: GDP-M1P_Guanylyltransferase; cd02509 114615012908 Substrate binding site [chemical binding]; other site 114615012909 Cupin domain; Region: Cupin_2; cl09118 114615012910 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 114615012911 UDP glucuronic acid epimerase, extended (e) SDRs; Region: UDP_GE_SDE_e; cd05253 114615012912 putative NAD(P) binding site [chemical binding]; other site 114615012913 active site 114615012914 putative substrate binding site [chemical binding]; other site 114615012915 Vi polysaccharide biosynthesis protein TviB; Provisional; Region: PRK15182 114615012916 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 114615012917 UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984 114615012918 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 114615012919 Uncharacterised protein family (UPF0104); Region: UPF0104; cl04219 114615012920 exosortase 1 system-associated amidotransferase 1; Region: eps_aminotran_1; TIGR03108 114615012921 Glutamine amidotransferases class-II (GATase) asparagine synthase_B type. Asparagine synthetase B catalyses the ATP-dependent conversion of aspartate to asparagine. This enzyme is a homodimer, with each monomer composed of a glutaminase domain and a...; Region: AsnB; cd00712 114615012922 active site 114615012923 dimer interface [polypeptide binding]; other site 114615012924 The C-terminal domain of Asparagine Synthase B. This domain is always found associated n-terminal amidotransferase domain. Family members that contain this domain catalyse the conversion of aspartate to asparagine. Asparagine synthetase B catalyzes...; Region: Asn_Synthase_B_C; cd01991 114615012925 Ligand Binding Site [chemical binding]; other site 114615012926 Molecular Tunnel; other site 114615012927 Predicted acyltransferases [Lipid metabolism]; Region: COG1835 114615012928 Predicted acyltransferases [Lipid metabolism]; Region: COG1835 114615012929 Predicted acyltransferases [Lipid metabolism]; Region: COG1835 114615012930 MBOAT family; Region: MBOAT; cl00738 114615012931 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 114615012932 active site 114615012933 nucleotide binding site [chemical binding]; other site 114615012934 HIGH motif; other site 114615012935 KMSKS motif; other site 114615012936 RfaE encodes a bifunctional ADP-heptose synthase involved in the biosynthesis of the lipopolysaccharide (LPS) core precursor ADP-L-glycero-D-manno-heptose. LPS plays an important role in maintaining the structural integrity of the bacterial outer...; Region: RfaE_like; cd01172 114615012937 pfkB family carbohydrate kinase; Region: PfkB; pfam00294 114615012938 putative ribose interaction site [chemical binding]; other site 114615012939 putative ADP binding site [chemical binding]; other site 114615012940 NTP_transferases catalyze the transfer of nucleotides onto phosphosugars; Region: NTP_transferase; cd04181 114615012941 active site 114615012942 Substrate binding site [chemical binding]; other site 114615012943 Mg++ binding site [ion binding]; other site 114615012944 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 114615012945 extended (e) SDRs; Region: SDR_e; cd08946 114615012946 NAD(P) binding site [chemical binding]; other site 114615012947 active site 114615012948 substrate binding site [chemical binding]; other site 114615012949 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 114615012950 Phosphoheptose isomerase is a member of the SIS (Sugar ISomerase) superfamily. Phosphoheptose isomerase catalyzes the isomerization of sedoheptulose 7-phosphate into D-glycero-D-mannoheptose 7-phosphate. This is the first step of the biosynthesis of...; Region: SIS_GmhA; cd05006 114615012951 dimer interface [polypeptide binding]; other site 114615012952 active site 114615012953 dTDP-D-glucose 4,6-dehydratase [Cell envelope biogenesis, outer membrane]; Region: RfbB; COG1088 114615012954 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 114615012955 NAD(P) binding site [chemical binding]; other site 114615012956 active site 114615012957 Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012 114615012958 TPP-binding site [chemical binding]; other site 114615012959 dimer interface [polypeptide binding]; other site 114615012960 Transketolase, C-terminal subunit [Carbohydrate transport and metabolism]; Region: COG3958 114615012961 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 114615012962 PYR/PP interface [polypeptide binding]; other site 114615012963 dimer interface [polypeptide binding]; other site 114615012964 TPP binding site [chemical binding]; other site 114615012965 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 114615012966 Zn-dependent alcohol dehydrogenases, class III [Energy production and conversion]; Region: AdhC; COG1062 114615012967 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl14614 114615012968 NAD(P) binding site [chemical binding]; other site 114615012969 Predicted aminoglycoside phosphotransferase [General function prediction only]; Region: COG3173 114615012970 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 114615012971 active site 114615012972 ATP binding site [chemical binding]; other site 114615012973 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 114615012974 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cd02440 114615012975 S-adenosylmethionine binding site [chemical binding]; other site 114615012976 Hypothetical methyltransferase; Region: Methyltransf_13; pfam08421 114615012977 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cl12011 114615012978 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 114615012979 classical (c) SDRs; Region: SDR_c; cd05233 114615012980 NAD(P) binding site [chemical binding]; other site 114615012981 active site 114615012982 Hypothetical methyltransferase; Region: Methyltransf_13; pfam08421 114615012983 hypothetical protein; Provisional; Region: PRK08317 114615012984 C-methyltransferase C-terminal domain; Region: Methyltransf_14; pfam08484 114615012985 ABC-2 type transporter; Region: ABC2_membrane; cl11417 114615012986 ABC-type polysaccharide/polyol phosphate transport system, ATPase component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagH; COG1134 114615012987 ABC_KpsT_Wzt The KpsT/Wzt ABC transporter subfamily is involved in extracellular polysaccharide export. Among the variety of membrane-linked or extracellular polysaccharides excreted by bacteria, only capsular polysaccharides, lipopolysaccharides...; Region: ABC_KpsT_Wzt; cd03220 114615012988 Walker A/P-loop; other site 114615012989 ATP binding site [chemical binding]; other site 114615012990 Q-loop/lid; other site 114615012991 ABC transporter signature motif; other site 114615012992 Walker B; other site 114615012993 D-loop; other site 114615012994 H-loop/switch region; other site 114615012995 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 114615012996 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 114615012997 active site 114615012998 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi...; Region: TPR; cd00189 114615012999 binding surface 114615013000 TPR motif; other site 114615013001 WcxM-like, Left-handed parallel beta-Helix (LbH) N-terminal domain: This group is composed of Xanthomonas campestris WcxM and proteins with similarity to the WcxM N-terminal domain. WcxM is thought to be bifunctional, catalyzing both the isomerization...; Region: LbH_WxcM_N_like; cd03358 114615013002 putative trimer interface [polypeptide binding]; other site 114615013003 putative active site [active] 114615013004 putative substrate binding site [chemical binding]; other site 114615013005 putative CoA binding site [chemical binding]; other site 114615013006 Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WecE; COG0399 114615013007 3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616 114615013008 inhibitor-cofactor binding pocket; inhibition site 114615013009 pyridoxal 5'-phosphate binding site [chemical binding]; other site 114615013010 catalytic residue [active] 114615013011 Stf0 sulphotransferase; Region: Sulphotransf; cl01835 114615013012 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 114615013013 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 114615013014 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 114615013015 NAD dependent epimerase/dehydratase family; Region: Epimerase; pfam01370 114615013016 NAD(P) binding site [chemical binding]; other site 114615013017 active site 114615013018 Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WecE; COG0399 114615013019 3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616 114615013020 inhibitor-cofactor binding pocket; inhibition site 114615013021 pyridoxal 5'-phosphate binding site [chemical binding]; other site 114615013022 catalytic residue [active] 114615013023 sulfate adenylyltransferase, small subunit; Region: CysD; TIGR02039 114615013024 This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713 114615013025 Active Sites [active] 114615013026 bifunctional sulfate adenylyltransferase subunit 1/adenylylsulfate kinase protein; Provisional; Region: PRK05506 114615013027 CysN_ATPS subfamily. CysN, together with protein CysD, form the ATP sulfurylase (ATPS) complex in some bacteria and lower eukaryotes. ATPS catalyzes the production of ATP sulfurylase (APS) and pyrophosphate (PPi) from ATP and sulfate. CysD, which...; Region: CysN_ATPS; cd04166 114615013028 CysD dimerization site [polypeptide binding]; other site 114615013029 G1 box; other site 114615013030 putative GEF interaction site [polypeptide binding]; other site 114615013031 GTP/Mg2+ binding site [chemical binding]; other site 114615013032 Switch I region; other site 114615013033 G2 box; other site 114615013034 G3 box; other site 114615013035 Switch II region; other site 114615013036 G4 box; other site 114615013037 G5 box; other site 114615013038 CysN_NodQ_II: This subfamily represents the domain II of the large subunit of ATP sulfurylase (ATPS): CysN or the N-terminal portion of NodQ, found mainly in proteobacteria and homologous to the domain II of EF-Tu. Escherichia coli ATPS consists of...; Region: CysN_NodQ_II; cd03695 114615013039 TCysN_NoDQ_II: This subfamily represents the domain II of the large subunit of ATP sulfurylase (ATPS): CysN or the N-terminal portion of NodQ, found mainly in proteobacteria and homologous to the domain II of EF-Tu. Escherichia coli ATPS consists of...; Region: CysN_NoDQ_III; cd04095 114615013040 Adenosine 5'-phosphosulfate kinase (APSK) catalyzes the phosphorylation of adenosine 5'-phosphosulfate to form 3'-phosphoadenosine 5'-phosphosulfate (PAPS). The end-product PAPS is a biologically 'activated' sulfate form important for the assimilation...; Region: APSK; cd02027 114615013041 ligand-binding site [chemical binding]; other site 114615013042 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cd02440 114615013043 S-adenosylmethionine binding site [chemical binding]; other site 114615013044 Polysaccharide deacetylase; Region: Polysacc_deac_1; cl12061 114615013045 undecaprenyl phosphate 4-deoxy-4-formamido-L-arabinose transferase; Provisional; Region: PRK10714 114615013046 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 114615013047 This family is most closely related to the GT1 family of glycosyltransferases. cap1E in Streptococcus pneumoniae is required for the synthesis of type 1 capsular polysaccharides; Region: GT1_cap1E_like; cd03808 114615013048 putative ADP-binding pocket [chemical binding]; other site 114615013049 The members of this subfamily catalyze the formation of a phosphodiester bond between a membrane-associated undecaprenyl-phosphate (Und-P) molecule and N-acetylhexosamine 1-phosphate, which is usually donated by a soluble UDP-N-acetylhexosamine...; Region: GT_WbpL_WbcO_like; cd06854 114615013050 Mg++ binding site [ion binding]; other site 114615013051 putative catalytic motif [active] 114615013052 putative substrate binding site [chemical binding]; other site 114615013053 Predicted nucleoside-diphosphate sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG1086 114615013054 UDP-Glcnac (UDP-linked N-acetylglucosamine) inverting 4,6-dehydratase, extended (e) SDRs; Region: UDP_invert_4-6DH_SDR_e; cd05237 114615013055 NAD(P) binding site [chemical binding]; other site 114615013056 homodimer interface [polypeptide binding]; other site 114615013057 substrate binding site [chemical binding]; other site 114615013058 active site 114615013059 O-Antigen ligase; Region: Wzy_C; cl04850 114615013060 ADP-heptose synthase, bifunctional sugar kinase/adenylyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaE; COG2870 114615013061 RfaE encodes a bifunctional ADP-heptose synthase involved in the biosynthesis of the lipopolysaccharide (LPS) core precursor ADP-L-glycero-D-manno-heptose. LPS plays an important role in maintaining the structural integrity of the bacterial outer...; Region: RfaE_like; cd01172 114615013062 putative ribose interaction site [chemical binding]; other site 114615013063 putative ADP binding site [chemical binding]; other site 114615013064 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 114615013065 active site 114615013066 HIGH motif; other site 114615013067 nucleotide binding site [chemical binding]; other site 114615013068 ADP-L-glycero-D-mannoheptose 6-epimerase (GME), extended (e) SDRs; Region: ADP_GME_SDR_e; cd05248 114615013069 ADP-L-glycero-D-manno-heptose-6-epimerase; Region: heptose_epim; TIGR02197 114615013070 NADP binding site [chemical binding]; other site 114615013071 homopentamer interface [polypeptide binding]; other site 114615013072 substrate binding site [chemical binding]; other site 114615013073 active site 114615013074 Lipopolysaccharide heptosyltransferase is involved in the biosynthesis of lipooligosaccharide (LOS). Lipopolysaccharide (LPS) is a major component of the outer membrane of gram-negative bacteria. LPS heptosyltransferase transfers heptose molecules from...; Region: GT1_LPS_heptosyltransferase; cd03789 114615013075 ADP-heptose:LPS heptosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaF; COG0859 114615013076 putative active site [active] 114615013077 Phosphoheptose isomerase is a member of the SIS (Sugar ISomerase) superfamily. Phosphoheptose isomerase catalyzes the isomerization of sedoheptulose 7-phosphate into D-glycero-D-mannoheptose 7-phosphate. This is the first step of the biosynthesis of...; Region: SIS_GmhA; cd05006 114615013078 dimer interface [polypeptide binding]; other site 114615013079 active site 114615013080 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others...; Region: HAD_like; cd01427 114615013081 active site 114615013082 motif I; other site 114615013083 motif II; other site 114615013084 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 114615013085 UDP-glucose 4-epimerase [Cell envelope biogenesis, outer membrane]; Region: GalE; COG1087 114615013086 UDP-glucose 4 epimerase, subgroup 1, extended (e) SDRs; Region: UDP_G4E_1_SDR_e; cd05247 114615013087 NAD binding site [chemical binding]; other site 114615013088 homodimer interface [polypeptide binding]; other site 114615013089 active site 114615013090 substrate binding site [chemical binding]; other site 114615013091 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 114615013092 ABC transporter transmembrane region; Region: ABC_membrane; cl00549 114615013093 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 114615013094 Walker A/P-loop; other site 114615013095 ATP binding site [chemical binding]; other site 114615013096 Q-loop/lid; other site 114615013097 ABC transporter signature motif; other site 114615013098 Walker B; other site 114615013099 D-loop; other site 114615013100 H-loop/switch region; other site 114615013101 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; cl11421 114615013102 RT_G2_intron: Reverse transcriptases (RTs) with group II intron origin. RT transcribes DNA using RNA as template. Proteins in this subfamily are found in bacterial and mitochondrial group II introns. Their most probable ancestor was a retrotransposable...; Region: RT_G2_intron; cd01651 114615013103 putative active site [active] 114615013104 putative NTP binding site [chemical binding]; other site 114615013105 putative nucleic acid binding site [nucleotide binding]; other site 114615013106 Putative cyclase; Region: Cyclase; cl00814 114615013107 Putative GTPases (G3E family) [General function prediction only]; Region: COG0523 114615013108 Ras-like GTPase superfamily. The Ras-like superfamily of small GTPases consists of several families with an extremely high degree of structural and functional similarity. The Ras superfamily is divided into at least four families in eukaryotes: the Ras...; Region: Ras_like_GTPase; cl10444 114615013109 Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; cl08458 114615013110 Aspartyl/Asparaginyl beta-hydroxylase; Region: Asp_Arg_Hydrox; cl01426 114615013111 PilZ domain; Region: PilZ; cl01260 114615013112 SAF domain; Region: SAF; cl00555 114615013113 Flp pilus assembly protein, secretin CpaC [Intracellular trafficking and secretion]; Region: CpaC; COG4964 114615013114 Bacterial type II and III secretion system protein; Region: Secretin; cl02829 114615013115 Type IV pili component [Cell motility and secretion]; Region: COG5461; cl02279 114615013116 Pilus biogenesis CpaD protein (pilus_cpaD); Region: Pilus_CpaD; pfam09476 114615013117 Flp pilus assembly protein, ATPase CpaE [Intracellular trafficking and secretion]; Region: CpaE; COG4963 114615013118 This protein family consists of proteins similar to the cpaE protein of the Caulobacter pilus assembly and the orf4 protein of Actinobacillus pilus formation gene cluster. The function of these proteins are unkown. The Caulobacter pilus assembly...; Region: CpaE_like; cd03111 114615013119 Flp pilus assembly protein TadD, contains TPR repeats [Intracellular trafficking and secretion]; Region: TadD; COG5010 114615013120 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi...; Region: TPR; cd00189 114615013121 TPR motif; other site 114615013122 binding surface 114615013123 cellulose synthase catalytic subunit (UDP-forming); Region: CelA; TIGR03030 114615013124 phenol 2-monooxygenase; Provisional; Region: PRK08294 114615013125 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 114615013126 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 114615013127 FAD-dependent Phenol hydoxylase (PHOX) family, C-terminal TRX-fold domain; composed of proteins similar to PHOX from the aerobic topsoil yeast Trichosporon cutaneum. PHOX is a flavoprotein monooxygenase that catalyzes the hydroxylation of phenol and...; Region: PHOX_C; cd02979 114615013128 dimer interface [polypeptide binding]; other site 114615013129 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 114615013130 Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072 114615013131 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 114615013132 Predicted metal-dependent hydrolases related to alanyl-tRNA synthetase HxxxH domain [General function prediction only]; Region: COG2872 114615013133 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 114615013134 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; cl08469 114615013135 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 114615013136 Phosphoinositide 3-kinase (PI3K)-like family, catalytic domain; The PI3K-like catalytic domain family is part of a larger superfamily that includes the catalytic domains of other kinases such as the typical serine/threonine/tyrosine protein kinases (...; Region: PI3Kc_like; cl00119 114615013137 catalytic loop [active] 114615013138 Cytochrome b (N-terminus)/b6/petB: Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria...; Region: Cytochrome_b_N; cl00859 114615013139 D-alanyl-D-alanine carboxypeptidase; Region: VanY; cl00813 114615013140 S-adenosyl-L-homocysteine hydrolase; Provisional; Region: PRK05476 114615013141 S-adenosyl-L-homocysteine hydrolase (AdoHycase) catalyzes the hydrolysis of S-adenosyl-L-homocysteine (AdoHyc) to form adenosine (Ado) and homocysteine (Hcy). The equilibrium lies far on the side of AdoHyc synthesis, but in nature the removal of Ado...; Region: AdoHcyase; cd00401 114615013142 oligomerization interface [polypeptide binding]; other site 114615013143 active site 114615013144 NAD+ binding site [chemical binding]; other site 114615013145 S-adenosylmethionine synthetase; Validated; Region: PRK05250 114615013146 S-adenosylmethionine synthetase, N-terminal domain; Region: S-AdoMet_synt_N; pfam00438 114615013147 S-adenosylmethionine synthetase, central domain; Region: S-AdoMet_synt_M; pfam02772 114615013148 S-adenosylmethionine synthetase, C-terminal domain; Region: S-AdoMet_synt_C; pfam02773 114615013149 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi...; Region: TPR; cd00189 114615013150 binding surface 114615013151 TPR motif; other site 114615013152 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi...; Region: TPR; cd00189 114615013153 binding surface 114615013154 TPR motif; other site 114615013155 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi...; Region: TPR; cd00189 114615013156 binding surface 114615013157 TPR motif; other site 114615013158 Caspase, interleukin-1 beta converting enzyme (ICE) homologues; Cysteine-dependent aspartate-directed proteases that mediate programmed cell death (apoptosis). Caspases are synthesized as inactive zymogens and activated by proteolysis of the peptide...; Region: CASc; cl00042 114615013159 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cl12011 114615013160 Uncharacterized protein conserved in bacteria (DUF2147); Region: DUF2147; cl01951 114615013161 SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cl01053 114615013162 active site 114615013163 catalytic triad [active] 114615013164 oxyanion hole [active] 114615013165 Predicted acyltransferases [Lipid metabolism]; Region: COG1835 114615013166 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl15258 114615013167 C-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme catalyses the last step in the production of methionine by...; Region: CIMS_C_terminal_like; cd03311 114615013168 substrate binding site [chemical binding]; other site 114615013169 THF binding site; other site 114615013170 zinc-binding site [ion binding]; other site 114615013171 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410 114615013172 LivF (TM1139) is part of the LIV-I bacterial ABC-type two-component transport system that imports neutral, branched-chain amino acids. The E. coli branched-chain amino acid transporter comprises a heterodimer of ABC transporters (LivF and LivG), a...; Region: ABC_TM1139_LivF_branched; cd03224 114615013173 Walker A/P-loop; other site 114615013174 ATP binding site [chemical binding]; other site 114615013175 Q-loop/lid; other site 114615013176 ABC transporter signature motif; other site 114615013177 Walker B; other site 114615013178 D-loop; other site 114615013179 H-loop/switch region; other site 114615013180 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411 114615013181 The Mj1267/LivG ABC transporter subfamily is involved in the transport of the hydrophobic amino acids leucine, isoleucine and valine. MJ1267 is a branched-chain amino acid transporter with 29% similarity to both the LivF and LivG components of the E...; Region: ABC_Mj1267_LivG_branched; cd03219 114615013182 Walker A/P-loop; other site 114615013183 ATP binding site [chemical binding]; other site 114615013184 Q-loop/lid; other site 114615013185 ABC transporter signature motif; other site 114615013186 Walker B; other site 114615013187 D-loop; other site 114615013188 H-loop/switch region; other site 114615013189 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 114615013190 TM-ABC transporter signature motif; other site 114615013191 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 114615013192 TM-ABC transporter signature motif; other site 114615013193 ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683 114615013194 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 114615013195 formyltetrahydrofolate deformylase; Reviewed; Region: purU; PRK06027 114615013196 N-terminal ACT domain of formyltetrahydrofolate deformylase (F4HF-DF; formyltetrahydrofolate hydrolase); Region: ACT_F4HF-DF; cd04875 114615013197 Formyltetrahydrofolate deformylase (Formyl-FH4 hydrolase), C-terminal hydrolase domain; Region: FMT_core_Formyl-FH4-Hydrolase_C; cd08648 114615013198 putative active site [active] 114615013199 putative substrate binding site [chemical binding]; other site 114615013200 putative cosubstrate binding site; other site 114615013201 catalytic site [active] 114615013202 Uroporphyrinogen-III synthase (HemD) catalyzes the asymmetrical cyclization of tetrapyrrole (linear) to uroporphyrinogen-III, the fourth step in the biosynthesis of heme. This ubiquitous enzyme is present in eukaryotes, bacteria and archaea. Mutations...; Region: HemD; cd06578 114615013203 active site 114615013204 Uroporphyrinogen-III synthase HemD; Region: HEM4; pfam02602 114615013205 GDP-4-keto-6-deoxymannose-3, 5-epimerase-4-reductase; Region: PLN02725 114615013206 GDP-fucose synthetase, extended (e) SDRs; Region: GDP_FS_SDR_e; cd05239 114615013207 NADP binding site [chemical binding]; other site 114615013208 active site 114615013209 putative substrate binding site [chemical binding]; other site 114615013210 GDP-mannose 4,6-dehydratase; Region: gmd; TIGR01472 114615013211 GDP-mannose 4,6 dehydratase, extended (e) SDRs; Region: GDP_MD_SDR_e; cd05260 114615013212 NADP-binding site; other site 114615013213 homotetramer interface [polypeptide binding]; other site 114615013214 substrate binding site [chemical binding]; other site 114615013215 homodimer interface [polypeptide binding]; other site 114615013216 active site 114615013217 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 114615013218 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 114615013219 ligand binding site [chemical binding]; other site 114615013220 flexible hinge region; other site 114615013221 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 114615013222 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411 114615013223 The Mj1267/LivG ABC transporter subfamily is involved in the transport of the hydrophobic amino acids leucine, isoleucine and valine. MJ1267 is a branched-chain amino acid transporter with 29% similarity to both the LivF and LivG components of the E...; Region: ABC_Mj1267_LivG_branched; cd03219 114615013224 Walker A/P-loop; other site 114615013225 ATP binding site [chemical binding]; other site 114615013226 Q-loop/lid; other site 114615013227 ABC transporter signature motif; other site 114615013228 Walker B; other site 114615013229 D-loop; other site 114615013230 H-loop/switch region; other site 114615013231 Long-chain acyl-CoA synthetases (AMP-forming) [Lipid metabolism]; Region: FAA1; COG1022 114615013232 Acyl-protein synthetase, LuxE; Region: LuxE; cl10450 114615013233 Acyl-protein synthetase, LuxE; Region: LuxE; cl10450 114615013234 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 114615013235 TM-ABC transporter signature motif; other site 114615013236 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 114615013237 TM-ABC transporter signature motif; other site 114615013238 ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683 114615013239 Type I periplasmic ligand-binding domain of uncharacterized ABC (ATPase Binding Cassette)-type active transport systems that are predicted to be involved in transport of amino acids, peptides, or inorganic ions; Region: PBP1_ABC_ligand_binding_like_1; cd06334 114615013240 putative ligand binding site [chemical binding]; other site 114615013241 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410 114615013242 LivF (TM1139) is part of the LIV-I bacterial ABC-type two-component transport system that imports neutral, branched-chain amino acids. The E. coli branched-chain amino acid transporter comprises a heterodimer of ABC transporters (LivF and LivG), a...; Region: ABC_TM1139_LivF_branched; cd03224 114615013243 Walker A/P-loop; other site 114615013244 ATP binding site [chemical binding]; other site 114615013245 Q-loop/lid; other site 114615013246 ABC transporter signature motif; other site 114615013247 Walker B; other site 114615013248 D-loop; other site 114615013249 H-loop/switch region; other site 114615013250 Acyl-protein synthetase, LuxE; Region: LuxE; cl10450 114615013251 CoA-transferase family III; Region: CoA_transf_3; cl00778 114615013252 Tripartite tricarboxylate transporter TctA family; Region: TctA; cl00772 114615013253 Tripartite tricarboxylate transporter TctB family; Region: TctB; pfam07331 114615013254 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3181 114615013255 Tripartite tricarboxylate transporter family receptor; Region: TctC; cl15260 114615013256 enoyl-CoA hydratase; Provisional; Region: PRK06144 114615013257 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase...; Region: crotonase-like; cd06558 114615013258 substrate binding site [chemical binding]; other site 114615013259 oxyanion hole (OAH) forming residues; other site 114615013260 trimer interface [polypeptide binding]; other site 114615013261 Serine-pyruvate aminotransferase/archaeal aspartate aminotransferase [Amino acid transport and metabolism]; Region: COG0075 114615013262 Alanine-glyoxylate aminotransferase (AGAT) family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to alanine-glyoxylate aminotransferase (AGAT), serine-...; Region: AGAT_like; cd06451 114615013263 homodimer interface [polypeptide binding]; other site 114615013264 pyridoxal 5'-phosphate binding site [chemical binding]; other site 114615013265 catalytic residue [active] 114615013266 Alanine-glyoxylate aminotransferase (AGAT) family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to alanine-glyoxylate aminotransferase (AGAT), serine-...; Region: AGAT_like; cd06451 114615013267 Serine-pyruvate aminotransferase/archaeal aspartate aminotransferase [Amino acid transport and metabolism]; Region: COG0075 114615013268 homodimer interface [polypeptide binding]; other site 114615013269 pyridoxal 5'-phosphate binding site [chemical binding]; other site 114615013270 catalytic residue [active] 114615013271 Transcriptional regulators [Transcription]; Region: GntR; COG1802 114615013272 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 114615013273 DNA-binding site [nucleotide binding]; DNA binding site 114615013274 FCD domain; Region: FCD; cl11656 114615013275 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 114615013276 FAD binding domain; Region: FAD_binding_4; pfam01565 114615013277 sn-glycerol-3-phosphate dehydrogenase subunit C; Provisional; Region: glpC; PRK11168 114615013278 Domain of unknown function (DUF336); Region: DUF336; cl01249 114615013279 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 114615013280 short chain dehydrogenase; Provisional; Region: PRK07109 114615013281 classical (c) SDR, subgroup 3; Region: SDR_c3; cd05360 114615013282 putative NAD(P) binding site [chemical binding]; other site 114615013283 active site 114615013284 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 114615013285 active site 114615013286 metal binding site [ion binding]; metal-binding site 114615013287 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 114615013288 Predicted membrane protein [Function unknown]; Region: COG2311 114615013289 Protein of unknown function (DUF418); Region: DUF418; cl12135 114615013290 enoyl-CoA hydratase; Provisional; Region: PRK05995 114615013291 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase...; Region: crotonase-like; cd06558 114615013292 substrate binding site [chemical binding]; other site 114615013293 oxyanion hole (OAH) forming residues; other site 114615013294 trimer interface [polypeptide binding]; other site 114615013295 Predicted acetyltransferases and hydrolases with the alpha/beta hydrolase fold [General function prediction only]; Region: LipA; COG1075 114615013296 Lipase. Lipases are esterases that can hydrolyze long-chain acyl-triglycerides into di- and monoglycerides, glycerol, and free fatty acids at a water/lipid interface. A typical feature of lipases is 'interfacial activation', the process of becoming...; Region: Lipase; cl14883 114615013297 nucleophilic elbow; other site 114615013298 catalytic triad; other site 114615013299 acylglycerophosphoethanolamine acyltransferase; Provisional; Region: PRK06814 114615013300 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 114615013301 putative substrate translocation pore; other site 114615013302 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 114615013303 putative acyl-acceptor binding pocket; other site 114615013304 Acyl-protein synthetase, LuxE; Region: LuxE; cl10450 114615013305 Anaerobic dehydrogenases, typically selenocysteine-containing [Energy production and conversion]; Region: BisC; COG0243 114615013306 The MopB_3 CD includes a group of related uncharacterized bacterial and archaeal molybdopterin-binding oxidoreductase-like domains with a putative N-terminal iron-sulfur [4Fe-4S] cluster binding site and molybdopterin cofactor binding site. These...; Region: MopB_3; cd02766 114615013307 putative [4Fe-4S] binding site [ion binding]; other site 114615013308 putative molybdopterin cofactor binding site [chemical binding]; other site 114615013309 The MopB_CT_3 CD includes a group of related uncharacterized bacterial molybdopterin-binding oxidoreductase-like domains with a putative N-terminal iron-sulfur [4Fe-4S] cluster binding site and molybdopterin cofactor binding site. This CD is of the...; Region: MopB_CT_3; cd02786 114615013310 putative molybdopterin cofactor binding site; other site 114615013311 Transcriptional regulators [Transcription]; Region: GntR; COG1802 114615013312 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 114615013313 DNA-binding site [nucleotide binding]; DNA binding site 114615013314 FCD domain; Region: FCD; cl11656 114615013315 Bacterial extracellular solute-binding protein, family 7; Region: SBP_bac_7; cl00710 114615013316 Tripartite ATP-independent periplasmic transporters, DctQ component; Region: DctQ; cl01181 114615013317 DctM-like transporters; Region: DctM; pfam06808 114615013318 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl09110 114615013319 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 114615013320 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 114615013321 ligand binding site [chemical binding]; other site 114615013322 flexible hinge region; other site 114615013323 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 114615013324 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 114615013325 ligand binding site [chemical binding]; other site 114615013326 flexible hinge region; other site 114615013327 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 114615013328 putative switch regulator; other site 114615013329 non-specific DNA interactions [nucleotide binding]; other site 114615013330 DNA binding site [nucleotide binding] 114615013331 sequence specific DNA binding site [nucleotide binding]; other site 114615013332 putative cAMP binding site [chemical binding]; other site 114615013333 Cytochrome c; Region: Cytochrom_C; cl11414 114615013334 ABC-type transport system involved in resistance to organic solvents, periplasmic component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2C; COG1463 114615013335 mce related protein; Region: MCE; pfam02470 114615013336 Protein of unknown function (DUF330); Region: DUF330; cl01135 114615013337 ABC-type transport system involved in resistance to organic solvents, ATPase component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2A; COG1127 114615013338 ABC (ATP-binding cassette) transport system involved in resistant to organic solvents; ABC transporters are a large family of proteins involved in the transport of a wide variety of different compounds, like sugars, ions, peptides, and more complex...; Region: ABC_Org_Solvent_Resistant; cd03261 114615013339 Walker A/P-loop; other site 114615013340 ATP binding site [chemical binding]; other site 114615013341 Q-loop/lid; other site 114615013342 ABC transporter signature motif; other site 114615013343 Walker B; other site 114615013344 D-loop; other site 114615013345 H-loop/switch region; other site 114615013346 Domain of unknown function DUF140; Region: DUF140; cl00510 114615013347 Acyl-CoA synthetase (NDP forming) [Energy production and conversion]; Region: COG1042 114615013348 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 114615013349 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 114615013350 Zn-dependent alcohol dehydrogenases [General function prediction only]; Region: AdhP; COG1064 114615013351 Cinnamyl alcohol dehydrogenases (CAD); Region: CAD2; cd08298 114615013352 putative NAD(P) binding site [chemical binding]; other site 114615013353 putative substrate binding site [chemical binding]; other site 114615013354 catalytic Zn binding site [ion binding]; other site 114615013355 structural Zn binding site [ion binding]; other site 114615013356 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2187 114615013357 Predicted kinase [General function prediction only]; Region: COG0645 114615013358 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 114615013359 Active site [active] 114615013360 Poly-beta-hydroxybutyrate polymerase N terminal; Region: PHBC_N; pfam12551 114615013361 poly(R)-hydroxyalkanoic acid synthase, class I; Region: PHA_synth_I; TIGR01838 114615013362 Poly-beta-hydroxybutyrate polymerase (PhaC) N-terminus; Region: PhaC_N; pfam07167 114615013363 FOG: CBS domain [General function prediction only]; Region: COG0517 114615013364 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the BON (bacterial OsmY and nodulation domain) domain. BON is a putative phospholipid-binding domain found in a family of osmotic shock protection...; Region: CBS_pair_BON_assoc; cd04586 114615013365 FOG: CBS domain [General function prediction only]; Region: COG0517 114615013366 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-...; Region: CBS_pair; cl09141 114615013367 CoA-transferase family III; Region: CoA_transf_3; cl00778 114615013368 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 114615013369 hypothetical protein; Region: PHA00649 114615013370 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 114615013371 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via trans-...; Region: HisKA; cd00082 114615013372 dimer interface [polypeptide binding]; other site 114615013373 phosphorylation site [posttranslational modification] 114615013374 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 114615013375 ATP binding site [chemical binding]; other site 114615013376 Mg2+ binding site [ion binding]; other site 114615013377 G-X-G motif; other site 114615013378 Response regulator receiver domain; Region: Response_reg; pfam00072 114615013379 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156 114615013380 active site 114615013381 phosphorylation site [posttranslational modification] 114615013382 intermolecular recognition site; other site 114615013383 dimerization interface [polypeptide binding]; other site 114615013384 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459 114615013385 Signal transduction histidine kinase, nitrogen specific [Signal transduction mechanisms]; Region: NtrB; COG3852 114615013386 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via trans-...; Region: HisKA; cd00082 114615013387 dimer interface [polypeptide binding]; other site 114615013388 phosphorylation site [posttranslational modification] 114615013389 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 114615013390 ATP binding site [chemical binding]; other site 114615013391 Mg2+ binding site [ion binding]; other site 114615013392 G-X-G motif; other site 114615013393 Response regulator receiver domain; Region: Response_reg; pfam00072 114615013394 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156 114615013395 active site 114615013396 phosphorylation site [posttranslational modification] 114615013397 intermolecular recognition site; other site 114615013398 dimerization interface [polypeptide binding]; other site 114615013399 Natural resistance-associated macrophage protein; Region: Nramp; cl00836 114615013400 malate dehydrogenase; Provisional; Region: PRK13529 114615013401 Malic enzyme, N-terminal domain; Region: malic; pfam00390 114615013402 NAD(P) binding domain of malic enzyme (ME), subgroup 1; Region: NAD_bind_1_malic_enz; cd05312 114615013403 NAD(P) binding site [chemical binding]; other site 114615013404 Arginase family; Region: Arginase; cl00306 114615013405 OpgC protein; Region: OpgC_C; cl10497 114615013406 Acyltransferase family; Region: Acyl_transf_3; pfam01757 114615013407 Phasin protein; Region: Phasin_2; cl11491 114615013408 Isoprenylcysteine carboxyl methyltransferase (ICMT) family; Region: ICMT; cl00763 114615013409 outer membrane protein assembly complex, YaeT protein; Region: OM_YaeT; TIGR03303 114615013410 Surface antigen variable number repeat; Region: Surf_Ag_VNR; cl10520 114615013411 Surface antigen variable number repeat; Region: Surf_Ag_VNR; cl10520 114615013412 Surface antigen variable number repeat; Region: Surf_Ag_VNR; cl10520 114615013413 Surface antigen variable number repeat; Region: Surf_Ag_VNR; cl10520 114615013414 Surface antigen; Region: Bac_surface_Ag; cl03097 114615013415 GcrA cell cycle regulator; Region: GcrA; cl11564 114615013416 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl15258 114615013417 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (...; Region: S24_LexA-like; cd06529 114615013418 Catalytic site [active] 114615013419 quinone oxidoreductase, NADPH-dependent; Provisional; Region: PRK10754 114615013420 Quinone oxidoreductase (QOR); Region: QOR2; cd05286 114615013421 NADP binding site [chemical binding]; other site 114615013422 dimer interface [polypeptide binding]; other site 114615013423 Small Multidrug Resistance protein; Region: Multi_Drug_Res; cl00910 114615013424 Predicted integral membrane protein [Function unknown]; Region: COG0392 114615013425 Pyridoxine 5'-phosphate (PNP) oxidase-like proteins; Region: PNPOx_like; cl00381 114615013426 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 114615013427 Active site [active] 114615013428 phosphonate metabolism protein PhnM; Provisional; Region: PRK15446 114615013429 PhnM is believed to be a subunit of the membrane associated C-P lyase complex. C-P lyase is thought to catalyze the direct cleavage of inactivated C-P bonds to yield inorganic phosphate and the corresponding hydrocarbons. It is responsible for cleavage...; Region: PhnM; cd01306 114615013430 active site 114615013431 phosphonate C-P lyase system protein PhnL; Region: CP_lyasePhnL; TIGR02324 114615013432 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 114615013433 Walker A/P-loop; other site 114615013434 ATP binding site [chemical binding]; other site 114615013435 Q-loop/lid; other site 114615013436 ABC transporter signature motif; other site 114615013437 Walker B; other site 114615013438 D-loop; other site 114615013439 phosphonate C-P lyase system protein PhnK; Provisional; Region: phnK; PRK11701 114615013440 The ABC transporter subfamily specific for the transport of dipeptides, oligopeptides (OppD), and nickel (NikDE). The NikABCDE system of E. coli belongs to this family and is composed of the periplasmic binding protein NikA, two integral membrane...; Region: ABC_NikE_OppD_transporters; cd03257 114615013441 Walker A/P-loop; other site 114615013442 ATP binding site [chemical binding]; other site 114615013443 Q-loop/lid; other site 114615013444 ABC transporter signature motif; other site 114615013445 Walker B; other site 114615013446 D-loop; other site 114615013447 H-loop/switch region; other site 114615013448 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 114615013449 Phosphonate metabolism protein PhnJ; Region: PhnJ; cl01457 114615013450 Bacterial phosphonate metabolism protein (PhnI); Region: PhnI; cl01456 114615013451 Bacterial phosphonate metabolism protein (PhnH); Region: PhnH; cl01455 114615013452 Phosphonate metabolism protein PhnG; Region: PhnG; cl01454 114615013453 phosphonates metabolism transcriptional regulator PhnF; Region: C_P_lyase_phnF; TIGR02325 114615013454 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 114615013455 DNA-binding site [nucleotide binding]; DNA binding site 114615013456 UTRA domain; Region: UTRA; cl01230 114615013457 Enterobacter aerogenes GpdQ and related proteins, metallophosphatase domain; Region: MPP_GpdQ; cd07402 114615013458 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 114615013459 active site 114615013460 metal binding site [ion binding]; metal-binding site 114615013461 hexamer interface [polypeptide binding]; other site 114615013462 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 114615013463 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 114615013464 Walker A/P-loop; other site 114615013465 ATP binding site [chemical binding]; other site 114615013466 Q-loop/lid; other site 114615013467 ABC transporter signature motif; other site 114615013468 Walker B; other site 114615013469 D-loop; other site 114615013470 H-loop/switch region; other site 114615013471 TOBE domain; Region: TOBE_2; cl01440 114615013472 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261 114615013473 putative PBP binding loops; other site 114615013474 dimer interface [polypeptide binding]; other site 114615013475 ABC-ATPase subunit interface; other site 114615013476 ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555 114615013477 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cl00427 114615013478 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 114615013479 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cl00427 114615013480 phosphonate ABC transporter, permease protein PhnE; Region: PhnE; TIGR01097 114615013481 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261 114615013482 dimer interface [polypeptide binding]; other site 114615013483 conserved gate region; other site 114615013484 putative PBP binding loops; other site 114615013485 ABC-ATPase subunit interface; other site 114615013486 Tripartite tricarboxylate transporter family receptor; Region: TctC; cl15260 114615013487 phosphonate ABC transporter, periplasmic phosphonate binding protein; Region: PhnD; TIGR03431 114615013488 phosphonate ABC transporter, ATP-binding protein; Region: ABC_phnC; TIGR02315 114615013489 ABC-type phosphate/phosphonate transport system. Phosphonates are a class of organophosphorus compounds characterized by a chemically stable carbon-to-phosphorus (C-P) bond. Phosphonates are widespread among naturally occurring compounds in all...; Region: ABC_PhnC_transporter; cd03256 114615013490 Walker A/P-loop; other site 114615013491 ATP binding site [chemical binding]; other site 114615013492 Q-loop/lid; other site 114615013493 ABC transporter signature motif; other site 114615013494 Walker B; other site 114615013495 D-loop; other site 114615013496 H-loop/switch region; other site 114615013497 phosphonate metabolim protein, transferase hexapeptide repeat family; Region: phn_thr-fam; TIGR03308 114615013498 Xenobiotic acyltransferase (XAT): The XAT class of hexapeptide acyltransferases is composed of a large number of microbial enzymes that catalyze the CoA-dependent acetylation of a variety of hydroxyl-bearing acceptors such as chloramphenicol and...; Region: LbH_XAT; cd03349 114615013499 trimer interface [polypeptide binding]; other site 114615013500 active site 114615013501 substrate binding site [chemical binding]; other site 114615013502 CoA binding site [chemical binding]; other site 114615013503 phosphonate metabolism protein PhnM; Provisional; Region: PRK15446 114615013504 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have...; Region: metallo-dependent_hydrolases; cl00281 114615013505 active site 114615013506 putative phosphonate metabolism protein; Region: Phn_opern_protn; TIGR03223 114615013507 Protein of unknown function (DUF1045); Region: DUF1045; pfam06299 114615013508 Mechanosensitive ion channel; Region: MS_channel; pfam00924 114615013509 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 114615013510 classical (c) SDRs; Region: SDR_c; cd05233 114615013511 NAD(P) binding site [chemical binding]; other site 114615013512 active site 114615013513 Acetamidase/Formamidase family; Region: FmdA_AmdA; cl01023 114615013514 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 114615013515 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cl00427 114615013516 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 114615013517 NrtD and SsuB are the ATP-binding subunits of the bacterial ABC-type nitrate and sulfonate transport systems, respectively. ABC transporters are a large family of proteins involved in the transport of a wide variety of different compounds, like sugars...; Region: ABC_NrtD_SsuB_transporters; cd03293 114615013518 Walker A/P-loop; other site 114615013519 ATP binding site [chemical binding]; other site 114615013520 Q-loop/lid; other site 114615013521 ABC transporter signature motif; other site 114615013522 Walker B; other site 114615013523 D-loop; other site 114615013524 H-loop/switch region; other site 114615013525 ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components [Inorganic ion transport and metabolism]; Region: TauA; COG0715 114615013526 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cl01709 114615013527 Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450 114615013528 Peroxiredoxin (PRX) family, Typical 2-Cys PRX subfamily; PRXs are thiol-specific antioxidant (TSA) proteins, which confer a protective role in cells through its peroxidase activity by reducing hydrogen peroxide, peroxynitrite, and organic...; Region: PRX_Typ2cys; cd03015 114615013529 dimer interface [polypeptide binding]; other site 114615013530 decamer (pentamer of dimers) interface [polypeptide binding]; other site 114615013531 catalytic triad [active] 114615013532 peroxidatic and resolving cysteines [active] 114615013533 alkylhydroperoxidase, AhpD family; Region: ahpD; TIGR00777 114615013534 Carboxymuconolactone decarboxylase family; Region: CMD; cl00460 114615013535 ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683 114615013536 Type I periplasmic ligand-binding domain of uncharacterized ABC (ATPase Binding Cassette)-type active transport systems that are predicted to be involved in uptake of amino acids, peptides, or inorganic ions; Region: PBP1_ABC_ligand_binding_like_8; cd06343 114615013537 putative ligand binding site [chemical binding]; other site 114615013538 Tripartite tricarboxylate transporter family receptor; Region: TctC; cl15260 114615013539 Phosphoribosyltransferase (PRTase) type II; This family contains two enzymes that play an important role in NAD production by either allowing quinolinic acid (QA) , quinolinate phosphoribosyl transferase (QAPRTase), or nicotinic acid (NA), nicotinate...; Region: PRTase_typeII; cl12019 114615013540 putative molybdenum utilization protein ModD; Region: modD; TIGR01334 114615013541 active site 114615013542 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 114615013543 TOBE domain; Region: TOBE_2; cl01440 114615013544 Ferredoxin-like protein [Energy production and conversion]; Region: FixX; COG2440 114615013545 putative oxidoreductase FixC; Provisional; Region: PRK10157 114615013546 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 114615013547 Electron transfer flavoprotein, alpha subunit [Energy production and conversion]; Region: FixB; COG2025 114615013548 The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_alpha; cd01715 114615013549 Electron transfer flavoprotein FAD-binding domain; Region: ETF_alpha; pfam00766 114615013550 Electron transfer flavoprotein, beta subunit [Energy production and conversion]; Region: FixA; COG2086 114615013551 The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_beta; cd01714 114615013552 Ligand binding site [chemical binding]; other site 114615013553 Nitrogen fixation protein NifW; Region: NifW; cl03935 114615013554 serine O-acetyltransferase; Region: cysE; TIGR01172 114615013555 Serine acetyltransferase, N-terminal; Region: SATase_N; cl05762 114615013556 Serine acetyltransferase (SAT): SAT catalyzes the CoA-dependent acetylation of the side chain hydroxyl group of L-serine to form O-acetylserine, as the first step of a two-step biosynthetic pathway in bacteria and plants leading to the formation of L-...; Region: LbH_SAT; cd03354 114615013557 trimer interface [polypeptide binding]; other site 114615013558 active site 114615013559 substrate binding site [chemical binding]; other site 114615013560 CoA binding site [chemical binding]; other site 114615013561 homocitrate synthase NifV; Region: nifV_homocitr; TIGR02660 114615013562 Streptomyces rubellomurinus FrbC and related proteins, catalytic TIM barrel domain; Region: DRE_TIM_NifV; cd07939 114615013563 active site 114615013564 catalytic residues [active] 114615013565 metal binding site [ion binding]; metal-binding site 114615013566 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 114615013567 metal binding site 2 [ion binding]; metal-binding site 114615013568 putative DNA binding helix; other site 114615013569 metal binding site 1 [ion binding]; metal-binding site 114615013570 dimer interface [polypeptide binding]; other site 114615013571 structural Zn2+ binding site [ion binding]; other site 114615013572 NifQ; Region: NifQ; pfam04891 114615013573 nitrogenase reductase; Reviewed; Region: nifH; PRK13234 114615013574 NifH gene encodes component II (iron protein) of nitrogenase. Nitrogenase is responsible for the biological nitrogen fixation, i.e. reduction of molecular nitrogen to ammonia. NifH consists of two oxygen-sensitive metallosulfur proteins: the...; Region: NifH; cd02040 114615013575 Nucleotide-binding sites [chemical binding]; other site 114615013576 Walker A motif; other site 114615013577 Switch I region of nucleotide binding site; other site 114615013578 Fe4S4 binding sites [ion binding]; other site 114615013579 Switch II region of nucleotide binding site; other site 114615013580 Response regulator receiver domain; Region: Response_reg; pfam00072 114615013581 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156 114615013582 active site 114615013583 phosphorylation site [posttranslational modification] 114615013584 intermolecular recognition site; other site 114615013585 dimerization interface [polypeptide binding]; other site 114615013586 Arsenate Reductase (ArsC) family, 15kD protein subfamily; composed of proteins of unknown function with similarity to thioredoxin-fold arsenic reductases, ArsC. It is encoded by an ORF present in a gene cluster associated with nitrogen fixation that...; Region: ArsC_15kD; cd03033 114615013587 putative catalytic residues [active] 114615013588 Thioredoxin (TRX)-like [2Fe-2S] Ferredoxin (Fd) family; composed of [2Fe-2S] Fds with a TRX fold (TRX-like Fds) and proteins containing domains similar to TRX-like Fd including formate dehydrogenases, NAD-reducing hydrogenases and the subunit E of NADH:; Region: TRX_Fd_family; cd02980 114615013589 dimer interface [polypeptide binding]; other site 114615013590 [2Fe-2S] cluster binding site [ion binding]; other site 114615013591 Glutaredoxin (GRX) family, PKC-interacting cousin of TRX (PICOT)-like subfamily; composed of PICOT and GRX-PICOT-like proteins. The non-PICOT members of this family contain only the GRX-like domain, whereas PICOT contains an N-terminal TRX-like domain...; Region: GRX_PICOT_like; cd03028 114615013592 putative GSH binding site [chemical binding]; other site 114615013593 catalytic residues [active] 114615013594 BolA-like protein; Region: BolA; cl00386 114615013595 Domain of unknown function DUF59; Region: DUF59; cl00941 114615013596 Dienelactone hydrolase family; Region: DLH; pfam01738 114615013597 Transposase domain (DUF772); Region: DUF772; cl12084 114615013598 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 114615013599 Truncated hemoglobins (trHbs) are a family of oxygen-binding heme proteins found in cyanobacteria, eubacteria, unicellular eukaryotes, and plants. The truncated hemoglobins have a characteristic two-over-two alpha helical folding pattern that is...; Region: Trunc_globin; cd00454 114615013600 apolar tunnel; other site 114615013601 heme binding site [chemical binding]; other site 114615013602 dimerization interface [polypeptide binding]; other site 114615013603 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 114615013604 catalytic loop [active] 114615013605 iron binding site [ion binding]; other site 114615013606 Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WecE; COG0399 114615013607 3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616 114615013608 inhibitor-cofactor binding pocket; inhibition site 114615013609 pyridoxal 5'-phosphate binding site [chemical binding]; other site 114615013610 catalytic residue [active] 114615013611 Protein of unknown function (DUF3024); Region: DUF3024; pfam11225 114615013612 NifZ domain; Region: NifZ; pfam04319 114615013613 NifZ domain; Region: NifZ; pfam04319 114615013614 LRV protein FeS4 cluster; Region: LRV_FeS; pfam05484 114615013615 Iron-sulphur cluster biosynthesis; Region: Fe-S_biosyn; cl00400 114615013616 archaeoflavoprotein, MJ0208 family; Region: flavo_MJ0208; TIGR02700 114615013617 nitrogenase cofactor biosynthesis protein NifB; Region: nifB; TIGR01290 114615013618 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster...; Region: Radical_SAM; cd01335 114615013619 FeS/SAM binding site; other site 114615013620 NifB belongs to a family of iron-molybdenum cluster-binding proteins that includes NifX, and NifY, all of which are involved in the synthesis of an iron-molybdenum cofactor (FeMo-co) that binds the active site of the dinitrogenase enzyme as part of...; Region: NifB; cd00852 114615013621 SIR2 superfamily of proteins includes silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein/histone deacetylation, where the acetyl group from the lysine epsilon-amino group is transferred to the ADP-ribose moiety of NAD+...; Region: SIR2; cl00195 114615013622 NifT/FixU protein; Region: NifT; cl02351 114615013623 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 114615013624 cysteine desulfurase DndA; Region: DNA_S_dndA; TIGR03235 114615013625 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 114615013626 catalytic residue [active] 114615013627 NifU-like domain; Region: NifU; cl00484 114615013628 Iron-sulphur cluster biosynthesis; Region: Fe-S_biosyn; cl00400 114615013629 Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1)...; Region: Rieske; cd03467 114615013630 iron-sulfur cluster [ion binding]; other site 114615013631 [2Fe-2S] cluster binding site [ion binding]; other site 114615013632 3-mercaptopyruvate sulfurtransferase; Region: PLN02723 114615013633 Thiosulfate sulfurtransferase (TST), N-terminal, inactive domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the 1st repeat, which does not contain the catalytically active Cys residue. The role of the 1st repeat is uncertain, but...; Region: TST_Repeat_1; cd01448 114615013634 active site residue [active] 114615013635 Thiosulfate sulfurtransferase (TST), C-terminal, catalytic domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the second repeat. Only the second repeat contains the catalytically active Cys residue; Region: TST_Repeat_2; cd01449 114615013636 active site residue [active] 114615013637 Hemimethylated DNA-binding protein YccV like; Region: YccV-like; cl01548 114615013638 ferredoxin III, nif-specific; Region: fdxN_nitrog; TIGR02936 114615013639 Protein of unknown function (DUF683); Region: DUF683; cl02247 114615013640 Protein of unknown function, DUF269; Region: DUF269; cl03973 114615013641 NifX belongs to a family of iron-molybdenum cluster-binding proteins that includes NifB, and NifY, all of which are involved in the synthesis of an iron-molybdenum cofactor (FeMo-co) that binds the active site of the dinitrogenase enzyme. The protein...; Region: NifX; cd00853 114615013642 nitrogenase molybdenum-iron cofactor biosynthesis protein NifN; Region: nifN; TIGR01285 114615013643 Nitrogenase_nifN1: A subgroup of the NifN subunit of the NifEN complex: NifN forms an alpha2beta2 tetramer with NifE. NifN and nifE are structurally homologous to nitrogenase MoFe protein beta and alpha subunits respectively. NifEN participates in...; Region: Nitrogenase_NifN_1; cd01966 114615013644 nitrogenase molybdenum-cofactor biosynthesis protein NifE; Provisional; Region: PRK14478 114615013645 Nitrogenase_NifE_I: a subgroup of the NifE subunit of the NifEN complex: NifE forms an alpha2beta2 tetramer with NifN. NifE and NifN are structurally homologous to nitrogenase MoFe protein alpha and beta subunits respectively. NifEN participates in...; Region: Nitrogenase_NifE_I; cd01968 114615013646 BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; cl01093 114615013647 nitrogenase molybdenum-iron protein beta chain; Region: nifK; TIGR01286 114615013648 Domain of unknown function (DUF3364); Region: DUF3364; pfam11844 114615013649 Nitrogenase_MoFe_beta: Nitrogenase MoFe protein, beta subunit. The nitrogenase enzyme catalyzes the ATP-dependent reduction of dinitrogen to ammonia. The Molybdenum (Mo-) nitrogenase is the most widespread and best characterized of these systems. Mo-...; Region: Nitrogenase_MoFe_beta; cd01974 114615013650 MoFe protein beta/alpha subunit interactions; other site 114615013651 Beta subunit P cluster binding residues; other site 114615013652 MoFe protein beta subunit/Fe protein contacts; other site 114615013653 MoFe protein dimer/ dimer interactions; other site 114615013654 nitrogenase molybdenum-iron cofactor biosynthesis protein NifE; Region: nifE; TIGR01283 114615013655 Nitrogenase_MoFe_alpha_II: Nitrogenase MoFe protein, beta subunit. A group of proteins similar to the alpha subunit of the MoFe protein of the molybdenum (Mo-) nitrogenase. The nitrogenase enzyme catalyzes the ATP-dependent reduction of dinitrogen to...; Region: Nitrogenase_MoFe_alpha; cd01976 114615013656 MoFe protein alpha/beta subunit interactions; other site 114615013657 Alpha subunit P cluster binding residues; other site 114615013658 FeMoco binding residues [chemical binding]; other site 114615013659 MoFe protein alpha subunit/Fe protein contacts; other site 114615013660 MoFe protein dimer/ dimer interactions; other site 114615013661 nitrogenase reductase; Reviewed; Region: nifH; PRK13234 114615013662 NifH gene encodes component II (iron protein) of nitrogenase. Nitrogenase is responsible for the biological nitrogen fixation, i.e. reduction of molecular nitrogen to ammonia. NifH consists of two oxygen-sensitive metallosulfur proteins: the...; Region: NifH; cd02040 114615013663 Nucleotide-binding sites [chemical binding]; other site 114615013664 Walker A motif; other site 114615013665 Switch I region of nucleotide binding site; other site 114615013666 Fe4S4 binding sites [ion binding]; other site 114615013667 Switch II region of nucleotide binding site; other site 114615013668 Response regulator receiver domain; Region: Response_reg; pfam00072 114615013669 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156 114615013670 active site 114615013671 phosphorylation site [posttranslational modification] 114615013672 intermolecular recognition site; other site 114615013673 dimerization interface [polypeptide binding]; other site 114615013674 Fe-S metabolism associated domain; Region: SufE; cl00951 114615013675 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 114615013676 Cysteine desulfurase (SufS)-like. This family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to cysteine desulfurase (SufS) and selenocysteine lyase. SufS...; Region: SufS_like; cd06453 114615013677 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 114615013678 catalytic residue [active] 114615013679 cysteine desulfurase activator complex subunit SufB; Provisional; Region: PRK11814; cl03223 114615013680 Uncharacterized protein family (UPF0051); Region: UPF0051; pfam01458 114615013681 FeS assembly ATPase SufC; Region: sufC; TIGR01978 114615013682 ABC-type transport system involved in Fe-S cluster assembly, ATPase component. Biosynthesis of iron-sulfur clusters (Fe-S) depends on multiprotein systems. The SUF system of E. coli and Erwinia chrysanthemi is important for Fe-S biogenesis under...; Region: ABC_FeS_Assembly; cd03217 114615013683 Walker A/P-loop; other site 114615013684 ATP binding site [chemical binding]; other site 114615013685 Q-loop/lid; other site 114615013686 ABC transporter signature motif; other site 114615013687 Walker B; other site 114615013688 D-loop; other site 114615013689 H-loop/switch region; other site 114615013690 cysteine desulfurase activator complex subunit SufB; Provisional; Region: PRK11814; cl03223 114615013691 putative ABC transporter; Region: ycf24; CHL00085 114615013692 hypothetical protein; Provisional; Region: PRK13795 114615013693 Nif-specific regulatory protein; Region: nifA; TIGR01817 114615013694 GAF domain; Region: GAF; cl00853 114615013695 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes...; Region: AAA; cd00009 114615013696 Walker A motif; other site 114615013697 ATP binding site [chemical binding]; other site 114615013698 Walker B motif; other site 114615013699 arginine finger; other site 114615013700 Bacterial regulatory protein, Fis family; Region: HTH_8; cl01091 114615013701 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 114615013702 classical (c) SDRs; Region: SDR_c; cd05233 114615013703 NAD(P) binding site [chemical binding]; other site 114615013704 active site 114615013705 Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2...; Region: Biotinyl_lipoyl_domains; cl11404 114615013706 BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; cl01093 114615013707 classical (c) SDR, subgroup 1; Region: SDR_c1; cd05355 114615013708 short chain dehydrogenase; Provisional; Region: PRK06701 114615013709 NAD binding site [chemical binding]; other site 114615013710 metal binding site [ion binding]; metal-binding site 114615013711 active site 114615013712 Protein of unknown function (DUF2934); Region: DUF2934; pfam11154 114615013713 Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices connected by an extended linker. The...; Region: HAMP; cl01054 114615013714 Histidine kinase; Region: HisKA_3; pfam07730 114615013715 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075 114615013716 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 114615013717 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156 114615013718 active site 114615013719 phosphorylation site [posttranslational modification] 114615013720 intermolecular recognition site; other site 114615013721 dimerization interface [polypeptide binding]; other site 114615013722 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors...; Region: LuxR_C_like; cd06170 114615013723 DNA binding residues [nucleotide binding] 114615013724 dimerization interface [polypeptide binding]; other site 114615013725 Predicted esterase [General function prediction only]; Region: COG0627 114615013726 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 114615013727 Protein of unknown function (DUF2380); Region: DUF3280; pfam11684 114615013728 Periplasmic binding domain of ATP-binding cassette transporter-like systems that belong to the type I periplasmic binding fold protein superfamily; Region: PBP1_ABC_transporter_LIVBP_like; cd06268 114615013729 ligand binding site [chemical binding]; other site 114615013730 PQQ-dependent catabolism-associated beta-propeller protein; Region: PQQ_ABC_repeats; TIGR03866 114615013731 40-residue YVTN family beta-propeller repeat; Region: beta_rpt_yvtn; TIGR02276 114615013732 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues...; Region: WD40; cl02567 114615013733 structural tetrad; other site 114615013734 40-residue YVTN family beta-propeller repeat; Region: beta_rpt_yvtn; TIGR02276 114615013735 PQQ-dependent alcohol dehydrogenase system; Region: PQQ_ABC_ATP; TIGR03864 114615013736 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 114615013737 Walker A/P-loop; other site 114615013738 ATP binding site [chemical binding]; other site 114615013739 Q-loop/lid; other site 114615013740 ABC transporter signature motif; other site 114615013741 Walker B; other site 114615013742 D-loop; other site 114615013743 H-loop/switch region; other site 114615013744 ABC-2 type transporter; Region: ABC2_membrane; cl11417 114615013745 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cl00125 114615013746 quinoprotein dehydrogenase-associated probable ABC transporter substrate-binding protein; Region: ABC_peri_MoxJ_2; TIGR03871 114615013747 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and...; Region: PBPb; cd00134 114615013748 substrate binding pocket [chemical binding]; other site 114615013749 membrane-bound complex binding site; other site 114615013750 hinge residues; other site 114615013751 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 114615013752 Predicted secreted protein [Function unknown]; Region: COG5501; cl02313 114615013753 Sulphur oxidation protein SoxZ; Region: SoxZ; pfam08770 114615013754 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and...; Region: PBPb; cd00134 114615013755 substrate binding pocket [chemical binding]; other site 114615013756 membrane-bound complex binding site; other site 114615013757 hinge residues; other site 114615013758 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261 114615013759 dimer interface [polypeptide binding]; other site 114615013760 conserved gate region; other site 114615013761 putative PBP binding loops; other site 114615013762 ABC-ATPase subunit interface; other site 114615013763 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 114615013764 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 114615013765 Walker A/P-loop; other site 114615013766 ATP binding site [chemical binding]; other site 114615013767 Q-loop/lid; other site 114615013768 ABC transporter signature motif; other site 114615013769 Walker B; other site 114615013770 D-loop; other site 114615013771 H-loop/switch region; other site 114615013772 EthD protein; Region: EthD; cl06234 114615013773 coenzyme PQQ synthesis protein PqqA; Provisional; Region: pqqA; cl14189 114615013774 PQQ-dependent dehydrogenase, methanol/ethanol family; Region: PQQ_enz_alc_DH; TIGR03075 114615013775 Dehydrogenases with pyrrolo-quinoline quinone (PQQ) as cofactor, like ethanol, methanol, and membrane bound glucose dehydrogenases. The alignment model contains an 8-bladed beta-propeller; Region: PQQ_DH; cl11493 114615013776 Trp docking motif; other site 114615013777 'Velcro' closure; other site 114615013778 active site 114615013779 Cytochrome c; Region: Cytochrom_C; cl11414 114615013780 Bacterial periplasmic substrate-binding proteins; Region: PBPb; smart00062 114615013781 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and...; Region: PBPb; cd00134 114615013782 substrate binding pocket [chemical binding]; other site 114615013783 membrane-bound complex binding site; other site 114615013784 hinge residues; other site 114615013785 DNA-binding transcriptional activator FeaR; Provisional; Region: PRK09685 114615013786 PQQ-dependent dehydrogenase, methanol/ethanol family; Region: PQQ_enz_alc_DH; TIGR03075 114615013787 Dehydrogenases with pyrrolo-quinoline quinone (PQQ) as cofactor, like ethanol, methanol, and membrane bound glucose dehydrogenases. The alignment model contains an 8-bladed beta-propeller; Region: PQQ_DH; cl11493 114615013788 Trp docking motif; other site 114615013789 'Velcro' closure; other site 114615013790 active site 114615013791 c-type cytochrome, methanol metabolism-related; Region: 4cys_cytochr; TIGR03874 114615013792 class III alcohol dehydrogenases; Region: alcohol_DH_class_III; cd08300 114615013793 S-(hydroxymethyl)glutathione dehydrogenase/class III alcohol dehydrogenase; Region: adh_III_F_hyde; TIGR02818 114615013794 substrate binding site [chemical binding]; other site 114615013795 catalytic Zn binding site [ion binding]; other site 114615013796 NAD binding site [chemical binding]; other site 114615013797 structural Zn binding site [ion binding]; other site 114615013798 dimer interface [polypeptide binding]; other site 114615013799 Glutathione-dependent formaldehyde-activating enzyme; Region: GFA; cl01553 114615013800 Aerobic-type carbon monoxide dehydrogenase, small subunit CoxS/CutS homologs [Energy production and conversion]; Region: CoxS; COG2080 114615013801 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cl00159 114615013802 [2Fe-2S] binding domain; Region: Fer2_2; pfam01799 114615013803 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 114615013804 Aerobic-type carbon monoxide dehydrogenase, large subunit CoxL/CutL homologs [Energy production and conversion]; Region: CoxL; COG1529 114615013805 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; cl03161 114615013806 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 114615013807 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 114615013808 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cl01116 114615013809 Acetamidase/Formamidase family; Region: FmdA_AmdA; cl01023 114615013810 cytochrome c oxidase accessory protein FixG; Region: ccoG_rdxA_fixG; TIGR02745 114615013811 Ubp3 associated protein Bre5; Region: Bre5; pfam11614 114615013812 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; cl11421 114615013813 SOUL heme-binding protein; Region: SOUL; pfam04832 114615013814 Putative cyclase; Region: Cyclase; cl00814 114615013815 2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179 114615013816 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; cl11421 114615013817 ABC transporter, substrate-binding protein, aliphatic sulfonates family; Region: SsuA_fam; TIGR01728 114615013818 Tripartite tricarboxylate transporter family receptor; Region: TctC; cl15260 114615013819 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 114615013820 DNA-binding site [nucleotide binding]; DNA binding site 114615013821 FCD domain; Region: FCD; cl11656 114615013822 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 114615013823 NrtD and SsuB are the ATP-binding subunits of the bacterial ABC-type nitrate and sulfonate transport systems, respectively. ABC transporters are a large family of proteins involved in the transport of a wide variety of different compounds, like sugars...; Region: ABC_NrtD_SsuB_transporters; cd03293 114615013824 Walker A/P-loop; other site 114615013825 ATP binding site [chemical binding]; other site 114615013826 Q-loop/lid; other site 114615013827 ABC transporter signature motif; other site 114615013828 Walker B; other site 114615013829 D-loop; other site 114615013830 H-loop/switch region; other site 114615013831 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cl00427 114615013832 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cl00427 114615013833 flavocytochrome c; Region: flavo_cyto_c; TIGR01813 114615013834 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 114615013835 Isochorismatase family; Region: Isochorismatase; pfam00857 114615013836 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cd00431 114615013837 catalytic triad [active] 114615013838 conserved cis-peptide bond; other site 114615013839 N-methylhydantoinase A/acetone carboxylase, beta subunit [Amino acid transport and metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: HyuA; COG0145 114615013840 Hydantoinase/oxoprolinase N-terminal region; Region: Hydant_A_N; pfam05378 114615013841 Hydantoinase/oxoprolinase; Region: Hydantoinase_A; cl00668 114615013842 N-methylhydantoinase B/acetone carboxylase, alpha subunit [Amino acid transport and metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: HyuB; COG0146 114615013843 PEP phosphonomutase and related enzymes [Carbohydrate transport and metabolism]; Region: PrpB; COG2513 114615013844 Members of the ICL/PEPM enzyme family catalyze either P-C or C-C bond formation/cleavage. Known members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate hydrolase (OAH), isocitrate...; Region: ICL_PEPM; cd00377 114615013845 tetramer interface [polypeptide binding]; other site 114615013846 active site 114615013847 Mg2+/Mn2+ binding site [ion binding]; other site 114615013848 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410 114615013849 LivF (TM1139) is part of the LIV-I bacterial ABC-type two-component transport system that imports neutral, branched-chain amino acids. The E. coli branched-chain amino acid transporter comprises a heterodimer of ABC transporters (LivF and LivG), a...; Region: ABC_TM1139_LivF_branched; cd03224 114615013850 Walker A/P-loop; other site 114615013851 ATP binding site [chemical binding]; other site 114615013852 Q-loop/lid; other site 114615013853 ABC transporter signature motif; other site 114615013854 Walker B; other site 114615013855 D-loop; other site 114615013856 H-loop/switch region; other site 114615013857 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411 114615013858 The Mj1267/LivG ABC transporter subfamily is involved in the transport of the hydrophobic amino acids leucine, isoleucine and valine. MJ1267 is a branched-chain amino acid transporter with 29% similarity to both the LivF and LivG components of the E...; Region: ABC_Mj1267_LivG_branched; cd03219 114615013859 Walker A/P-loop; other site 114615013860 ATP binding site [chemical binding]; other site 114615013861 Q-loop/lid; other site 114615013862 ABC transporter signature motif; other site 114615013863 Walker B; other site 114615013864 D-loop; other site 114615013865 H-loop/switch region; other site 114615013866 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 114615013867 TM-ABC transporter signature motif; other site 114615013868 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 114615013869 TM-ABC transporter signature motif; other site 114615013870 ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683 114615013871 Type I periplasmic ligand-binding domain of uncharacterized ABC (ATPase Binding Cassette)-type active transport systems that are predicted to be involved in transport of amino acids, peptides, or inorganic ions; Region: PBP1_ABC_ligand_binding_like_6; cd06340 114615013872 putative ligand binding site [chemical binding]; other site 114615013873 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 114615013874 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 114615013875 DNA-binding site [nucleotide binding]; DNA binding site 114615013876 UTRA domain; Region: UTRA; cl01230 114615013877 mycofactocin system FadH/OYE family oxidoreductase 2; Region: mycofact_OYE_2; TIGR03997 114615013878 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl09108 114615013879 phosphate binding site [ion binding]; other site 114615013880 3-isopropylmalate dehydratase large subunit; Reviewed; Region: PRK00402 114615013881 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate; Region: IPMI; cd01583 114615013882 substrate binding site [chemical binding]; other site 114615013883 ligand binding site [chemical binding]; other site 114615013884 Aconatase-like swivel domain of 3-isopropylmalate dehydratase and related uncharacterized proteins. 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate 3-...; Region: IPMI_Swivel; cd01577 114615013885 substrate binding site [chemical binding]; other site 114615013886 Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cl00264 114615013887 Acetylornithine deacetylase/Succinyl-diaminopimelate desuccinylase and related deacylases [Amino acid transport and metabolism]; Region: ArgE; COG0624 114615013888 Uncharacterized M20 Dipeptidases; Region: M20_dipept_like_3; cd05680 114615013889 metal binding site [ion binding]; metal-binding site 114615013890 putative dimer interface [polypeptide binding]; other site 114615013891 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 114615013892 SIR2 superfamily of proteins includes silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein/histone deacetylation, where the acetyl group from the lysine epsilon-amino group is transferred to the ADP-ribose moiety of NAD+...; Region: SIR2; cl00195 114615013893 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 114615013894 Walker A motif; other site 114615013895 ATP binding site [chemical binding]; other site 114615013896 Walker B motif; other site 114615013897 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl09110 114615013898 DctM-like transporters; Region: DctM; pfam06808 114615013899 Tripartite ATP-independent periplasmic transporters, DctQ component; Region: DctQ; cl01181 114615013900 Bacterial extracellular solute-binding protein, family 7; Region: SBP_bac_7; cl00710 114615013901 2-isopropylmalate synthase; Validated; Region: PRK00915 114615013902 2-isopropylmalate synthase (IPMS), N-terminal catalytic TIM barrel domain; Region: DRE_TIM_IPMS; cd07940 114615013903 active site 114615013904 catalytic residues [active] 114615013905 metal binding site [ion binding]; metal-binding site 114615013906 LeuA allosteric (dimerisation) domain; Region: LeuA_dimer; cl07212 114615013907 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cl01116 114615013908 putative transposase OrfB; Reviewed; Region: PHA02517 114615013909 Integrase core domain; Region: rve; cl01316 114615013910 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 114615013911 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 114615013912 Beta-lactamase; Region: Beta-lactamase; cl01009 114615013913 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 114615013914 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 114615013915 ligand binding site [chemical binding]; other site 114615013916 flexible hinge region; other site 114615013917 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 114615013918 SCP_bacterial: SCP-like extracellular protein domain, as found in bacteria and archaea. The wider family of SCP containing proteins includes plant pathogenesis-related protein 1 (PR-1), CRISPs, mammalian cysteine-rich secretory proteins, and allergen 5...; Region: SCP_bacterial; cd05379 114615013919 NIF3 (NGG1p interacting factor 3); Region: NIF3; cl00412 114615013920 drug resistance transporter, Bcr/CflA subfamily; Region: efflux_Bcr_CflA; TIGR00710 114615013921 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 114615013922 putative substrate translocation pore; other site 114615013923 Surface antigen variable number repeat; Region: Surf_Ag_VNR; cl10520 114615013924 Surface antigen; Region: Bac_surface_Ag; cl03097 114615013925 Surface antigen; Region: Bac_surface_Ag; cl03097 114615013926 FecR protein; Region: FecR; pfam04773 114615013927 CHASE2 domain; Region: CHASE2; cl01732 114615013928 CHASE2 is an extracellular sensory domain, which is present in various classes of transmembrane receptors that are parts of signal transduction pathways in bacteria; Region: CHASE2; smart01080 114615013929 sensory histidine kinase DcuS; Provisional; Region: PRK11086 114615013930 PAS domain S-box; Region: sensory_box; TIGR00229 114615013931 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 114615013932 putative active site [active] 114615013933 heme pocket [chemical binding]; other site 114615013934 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 114615013935 metal binding site [ion binding]; metal-binding site 114615013936 active site 114615013937 I-site; other site 114615013938 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 114615013939 Polyphosphate kinase 2 (PPK2); Region: PPK2; cl11971 114615013940 Uncharacterized conserved protein [Function unknown]; Region: COG2326 114615013941 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or...; Region: Nudix_Hydrolase; cl00447 114615013942 ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components [Inorganic ion transport and metabolism]; Region: TauA; COG0715 114615013943 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and...; Region: PBPb; cd00134 114615013944 substrate binding pocket [chemical binding]; other site 114615013945 membrane-bound complex binding site; other site 114615013946 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261 114615013947 dimer interface [polypeptide binding]; other site 114615013948 conserved gate region; other site 114615013949 putative PBP binding loops; other site 114615013950 ABC-ATPase subunit interface; other site 114615013951 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 114615013952 NrtD and SsuB are the ATP-binding subunits of the bacterial ABC-type nitrate and sulfonate transport systems, respectively. ABC transporters are a large family of proteins involved in the transport of a wide variety of different compounds, like sugars...; Region: ABC_NrtD_SsuB_transporters; cd03293 114615013953 Walker A/P-loop; other site 114615013954 ATP binding site [chemical binding]; other site 114615013955 Q-loop/lid; other site 114615013956 ABC transporter signature motif; other site 114615013957 Walker B; other site 114615013958 D-loop; other site 114615013959 H-loop/switch region; other site 114615013960 sulfate ABC transporter, ATP-binding protein; Region: 3a0106s01; TIGR00968 114615013961 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 114615013962 Walker A/P-loop; other site 114615013963 ATP binding site [chemical binding]; other site 114615013964 Q-loop/lid; other site 114615013965 ABC transporter signature motif; other site 114615013966 Walker B; other site 114615013967 D-loop; other site 114615013968 H-loop/switch region; other site 114615013969 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261 114615013970 dimer interface [polypeptide binding]; other site 114615013971 conserved gate region; other site 114615013972 ABC-ATPase subunit interface; other site 114615013973 Tripartite tricarboxylate transporter family receptor; Region: TctC; cl15260 114615013974 Substrate binding domain of ABC-type glycine betaine transport system; Region: OpuAC; pfam04069 114615013975 Polysulfide-sulfurtransferase - Rhodanese Homology Domain. This domain is believed to serve as a polysulfide binding and transferase domain in anaerobic gram-negative bacteria, functioning in oxidative phosphorylation with polysulfide-sulfur as a...; Region: Polysulfide_ST; cd01447 114615013976 active site 114615013977 catalytic residue [active] 114615013978 Sulfatase; Region: Sulfatase; cl10460 114615013979 Protein of unknown function (DUF3592); Region: DUF3592; pfam12158 114615013980 short chain dehydrogenase; Provisional; Region: PRK05693 114615013981 17beta hydroxysteroid dehydrogenase-like, classical (c) SDRs; Region: 17beta-HSD-like_SDR_c; cd05374 114615013982 NADP binding site [chemical binding]; other site 114615013983 active site 114615013984 steroid binding site; other site 114615013985 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5330 114615013986 Uncharacterized protein conserved in bacteria (DUF2336); Region: DUF2336; pfam10098 114615013987 ketol-acid reductoisomerase; Provisional; Region: PRK05479 114615013988 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 114615013989 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvC; pfam01450 114615013990 LysE type translocator; Region: LysE; cl00565 114615013991 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cd02440 114615013992 S-adenosylmethionine binding site [chemical binding]; other site 114615013993 acetolactate synthase 3 regulatory subunit; Reviewed; Region: ilvH; PRK11895 114615013994 N-terminal ACT domain of the Escherichia coli IlvH-like regulatory subunit of acetohydroxyacid synthase (AHAS); Region: ACT_AHAS; cd04878 114615013995 putative valine binding site [chemical binding]; other site 114615013996 dimer interface [polypeptide binding]; other site 114615013997 Small subunit of acetolactate synthase; Region: ALS_ss_C; pfam10369 114615013998 Threonine dehydratase [Amino acid transport and metabolism]; Region: IlvA; COG1171 114615013999 Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562 114615014000 tetramer interface [polypeptide binding]; other site 114615014001 pyridoxal 5'-phosphate binding site [chemical binding]; other site 114615014002 catalytic residue [active] 114615014003 acetolactate synthase 3 catalytic subunit; Validated; Region: PRK09107 114615014004 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 114615014005 PYR/PP interface [polypeptide binding]; other site 114615014006 dimer interface [polypeptide binding]; other site 114615014007 TPP binding site [chemical binding]; other site 114615014008 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 114615014009 Thiamine pyrophosphate (TPP) family, Acetohydroxyacid synthase (AHAS) subfamily, TPP-binding module; composed of proteins similar to the large catalytic subunit of AHAS. AHAS catalyzes the condensation of two molecules of pyruvate to give the...; Region: TPP_AHAS; cd02015 114615014010 TPP-binding site [chemical binding]; other site 114615014011 dimer interface [polypeptide binding]; other site 114615014012 PIN domain of ribonucleases (toxins), VapC and FitB, of prokaryotic toxin/antitoxin operons, Pyrococcus horikoshii protein PH0500, and other similar bacterial and archaeal homologs; Region: PIN_VapC-FitB; cd09881 114615014013 oligomeric interface; other site 114615014014 putative active site [active] 114615014015 homodimer interface [polypeptide binding]; other site 114615014016 IPP transferase; Region: IPPT; cl00403 114615014017 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others...; Region: HAD_like; cl11391 114615014018 Phosphoserine phosphatase [Amino acid transport and metabolism]; Region: SerB; COG0560 114615014019 NADPH-dependent FMN reductase; Region: FMN_red; cl00438 114615014020 periplasmic serine protease, Do/DeqQ family; Region: degP_htrA_DO; TIGR02037 114615014021 Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic...; Region: Tryp_SPc; cl00149 114615014022 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind C-...; Region: PDZ_serine_protease; cd00987 114615014023 protein binding site [polypeptide binding]; other site 114615014024 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind C-...; Region: PDZ_serine_protease; cd00987 114615014025 protein binding site [polypeptide binding]; other site 114615014026 Uncharacterized protein conserved in bacteria (DUF2065); Region: DUF2065; cl01275 114615014027 FtsH protease regulator HflC; Provisional; Region: PRK11029 114615014028 Band_7_HflC: The band 7 domain of flotillin (reggie) like proteins. This group includes proteins similar to prokaryotic HlfC (High frequency of lysogenization C). Although many members of the band 7 family are lipid raft associated, prokaryote plasma...; Region: Band_7_HflC; cd03405 114615014029 Band_7_HflK: The band 7 domain of flotillin (reggie) like proteins. This group includes proteins similar to prokaryotic HlfK (High frequency of lysogenization K). Although many members of the band 7 family are lipid raft associated, prokaryote plasma...; Region: Band_7_HflK; cd03404 114615014030 HflK protein; Region: hflK; TIGR01933 114615014031 Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5,10-...; Region: DHFR; cd00209 114615014032 folate binding site [chemical binding]; other site 114615014033 NADP+ binding site [chemical binding]; other site 114615014034 Sortase and related acyltransferases [Cell envelope biogenesis, outer membrane]; Region: COG1247 114615014035 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 114615014036 Coenzyme A binding pocket [chemical binding]; other site 114615014037 Thymidylate synthase and pyrimidine hydroxymethylase: Thymidylate synthase (TS) and deoxycytidylate hydroxymethylase (dCMP-HMase) are homologs that catalyze analogous alkylation of C5 of pyrimidine nucleotides. Both enzymes are involved in the...; Region: TS_Pyrimidine_HMase; cd00351 114615014038 dimerization interface [polypeptide binding]; other site 114615014039 active site 114615014040 Tripartite tricarboxylate transporter TctA family; Region: TctA; cl00772 114615014041 Tripartite tricarboxylate transporter TctB family; Region: TctB; pfam07331 114615014042 Chromate transporter; Region: Chromate_transp; pfam02417 114615014043 Chromate transporter; Region: Chromate_transp; pfam02417 114615014044 Stringent starvation protein B; Region: SspB; cl01120 114615014045 fumarate hydratase; Reviewed; Region: fumC; PRK00485 114615014046 Class II fumarases; Region: Fumarase_classII; cd01362 114615014047 active site 114615014048 tetramer interface [polypeptide binding]; other site 114615014049 Uncharacterized protein related to arylsulfate sulfotransferase involved in siderophore biosynthesis [General function prediction only]; Region: COG4321 114615014050 FeoA domain; Region: FeoA; cl00838 114615014051 Ferrous iron transport protein B (FeoB) subfamily. E. coli has an iron(II) transport system, known as feo, which may make an important contribution to the iron supply of the cell under anaerobic conditions. FeoB has been identified as part of this...; Region: FeoB; cd01879 114615014052 ferrous iron transporter FeoB; Region: feoB; TIGR00437 114615014053 G1 box; other site 114615014054 GTP/Mg2+ binding site [chemical binding]; other site 114615014055 Switch I region; other site 114615014056 G2 box; other site 114615014057 G3 box; other site 114615014058 Switch II region; other site 114615014059 G4 box; other site 114615014060 G5 box; other site 114615014061 Nucleoside recognition; Region: Gate; cl00486 114615014062 Ferrous iron transport protein B C terminus; Region: FeoB_C; pfam07664 114615014063 Nucleoside recognition; Region: Gate; cl00486 114615014064 NADPH-dependent FMN reductase; Region: FMN_red; cl00438 114615014065 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 114615014066 LysR family transcriptional regulator; Provisional; Region: PRK14997 114615014067 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 114615014068 putative effector binding pocket; other site 114615014069 dimerization interface [polypeptide binding]; other site 114615014070 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 114615014071 Carboxylesterase family; Region: COesterase; pfam00135 114615014072 substrate binding pocket [chemical binding]; other site 114615014073 catalytic triad [active] 114615014074 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 114615014075 4-hydroxyphenylpyruvate dioxygenase and related hemolysins [Amino acid transport and metabolism / General function prediction only]; Region: COG3185 114615014076 N-terminal domain of 4-hydroxyphenylpyruvate dioxygenase (HPPD) and hydroxymandelate Synthase (HmaS); Region: HPPD_N_like; cd08342 114615014077 dimer interface [polypeptide binding]; other site 114615014078 C-terminal domain of 4-hydroxyphenylpyruvate dioxygenase (HppD) and hydroxymandelate Synthase (HmaS); Region: HPPD_C_like; cd07250 114615014079 active site 114615014080 Fe binding site [ion binding]; other site 114615014081 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410 114615014082 LivF (TM1139) is part of the LIV-I bacterial ABC-type two-component transport system that imports neutral, branched-chain amino acids. The E. coli branched-chain amino acid transporter comprises a heterodimer of ABC transporters (LivF and LivG), a...; Region: ABC_TM1139_LivF_branched; cd03224 114615014083 Walker A/P-loop; other site 114615014084 ATP binding site [chemical binding]; other site 114615014085 Q-loop/lid; other site 114615014086 ABC transporter signature motif; other site 114615014087 Walker B; other site 114615014088 D-loop; other site 114615014089 H-loop/switch region; other site 114615014090 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411 114615014091 The Mj1267/LivG ABC transporter subfamily is involved in the transport of the hydrophobic amino acids leucine, isoleucine and valine. MJ1267 is a branched-chain amino acid transporter with 29% similarity to both the LivF and LivG components of the E...; Region: ABC_Mj1267_LivG_branched; cd03219 114615014092 Walker A/P-loop; other site 114615014093 ATP binding site [chemical binding]; other site 114615014094 Q-loop/lid; other site 114615014095 ABC transporter signature motif; other site 114615014096 Walker B; other site 114615014097 D-loop; other site 114615014098 H-loop/switch region; other site 114615014099 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 114615014100 TM-ABC transporter signature motif; other site 114615014101 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 114615014102 TM-ABC transporter signature motif; other site 114615014103 ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683 114615014104 Periplasmic binding domain of ATP-binding cassette transporter-like systems that belong to the type I periplasmic binding fold protein superfamily; Region: PBP1_ABC_transporter_LIVBP_like; cd06268 114615014105 ligand binding site [chemical binding]; other site 114615014106 shikimate 5-dehydrogenase; Reviewed; Region: PRK12549 114615014107 Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501 114615014108 NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065 114615014109 NAD(P) binding site [chemical binding]; other site 114615014110 shikimate binding site; other site 114615014111 DNA-binding transcriptional regulator LysR; Provisional; Region: PRK11013 114615014112 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 114615014113 The C-terminal substrate-domain of LysR-type transcriptional regulators involved in the catabolism of opines and that of related regulators, contains the type 2 periplasmic binding fold; Region: PBP2_LysR_opines_like; cd08415 114615014114 putative dimerization interface [polypeptide binding]; other site 114615014115 putative assembly protein; Provisional; Region: PRK10833 114615014116 Cytochrome P450; Region: p450; cl12078 114615014117 Oxalate/Formate Antiporter; Region: 2A0111; TIGR00890 114615014118 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 114615014119 putative substrate translocation pore; other site 114615014120 The Class III extradiol dioxygenase, 4,5-DOPA Dioxygenase, catalyzes the incorporation of both atoms of molecular oxygen into 4,5-dihydroxy-phenylalanine; Region: 45_DOPA_Dioxygenase; cd07363 114615014121 putative active site [active] 114615014122 metal binding site [ion binding]; metal-binding site 114615014123 DoxX; Region: DoxX; cl00976 114615014124 transcriptional regulator; Provisional; Region: PRK10632 114615014125 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 114615014126 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 114615014127 putative effector binding pocket; other site 114615014128 dimerization interface [polypeptide binding]; other site 114615014129 Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659 114615014130 Sulfate transporter family; Region: Sulfate_transp; cl00967 114615014131 Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function; Region: STAS_SulP_like_sulfate_transporter; cd07042 114615014132 D-lactate dehydrogenase [cytochrome]; Region: PLN02805 114615014133 FAD binding domain; Region: FAD_binding_4; pfam01565 114615014134 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active...; Region: 4HBT; cd00586 114615014135 active site 114615014136 Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154 114615014137 GGCT-like domains, also called AIG2-like family. Gamma-glutamyl cyclotransferase (GGCT) catalyzes the formation of pyroglutamic acid (5-oxoproline) from dipeptides containing gamma-glutamyl, and is a dimeric protein. In Homo sapiens, the protein is...; Region: GGCT_like; cl11426 114615014138 Roadblock/LC7 domain; Region: Robl_LC7; cl00886 114615014139 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 114615014140 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 114615014141 ligand binding site [chemical binding]; other site 114615014142 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 114615014143 ligand binding site [chemical binding]; other site 114615014144 Superfamily I DNA and RNA helicases [DNA replication, recombination, and repair]; Region: UvrD; COG0210 114615014145 UvrD/REP helicase; Region: UvrD-helicase; cl14126 114615014146 ATP-dependent DNA helicase PcrA; Region: pcrA; TIGR01073 114615014147 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 114615014148 ligand binding site [chemical binding]; other site 114615014149 Protein of unknown function (DUF962); Region: DUF962; cl01879 114615014150 hopanoid-associated sugar epimerase; Region: HpnA; TIGR03466 114615014151 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 114615014152 NAD(P) binding site [chemical binding]; other site 114615014153 active site 114615014154 Isoprenylcysteine carboxyl methyltransferase (ICMT) family; Region: ICMT; cl00763 114615014155 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 114615014156 Lysin domain, found in a variety of enzymes involved in bacterial cell wall degradation. This domain may have a general peptidoglycan binding function; Region: LysM; cl00107 114615014157 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 114615014158 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 114615014159 Walker A/P-loop; other site 114615014160 ATP binding site [chemical binding]; other site 114615014161 Q-loop/lid; other site 114615014162 ABC transporter signature motif; other site 114615014163 Walker B; other site 114615014164 D-loop; other site 114615014165 H-loop/switch region; other site 114615014166 ABC-2 type transporter; Region: ABC2_membrane; cl11417 114615014167 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 114615014168 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 114615014169 TM-ABC transporter signature motif; other site 114615014170 ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129 114615014171 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 114615014172 Walker A/P-loop; other site 114615014173 ATP binding site [chemical binding]; other site 114615014174 Q-loop/lid; other site 114615014175 ABC transporter signature motif; other site 114615014176 Walker B; other site 114615014177 D-loop; other site 114615014178 H-loop/switch region; other site 114615014179 This family represents domain II of the carbohydrate uptake proteins that transport only monosaccharides (Monos). The Carb_Monos family is involved in the uptake of monosaccharides, such as pentoses (such as xylose, arabinose, and ribose) and hexoses (; Region: ABC_Carb_Monos_II; cd03215 114615014180 Periplasmic sugar-binding domain of Thermotoga maritima glucose-binding protein (tmGBP) and its close homologs; Region: PBP1_tmGBP; cd06314 114615014181 ligand binding site [chemical binding]; other site 114615014182 dimerization interface [polypeptide binding]; other site 114615014183 Phosphopantetheine attachment site; Region: PP-binding; cl09936 114615014184 peptide synthase; Validated; Region: PRK05691 114615014185 Acyl-protein synthetase, LuxE; Region: LuxE; cl10450 114615014186 MBOAT family; Region: MBOAT; cl00738 114615014187 The Delta9 Fatty Acid Desaturase (Delta9-FADS)-like CD includes the delta-9 and delta-11 acyl CoA desaturases found in various eukaryotes including vertebrates, insects, higher plants, and fungi. The delta-9 acyl-lipid desaturases are found in a wide...; Region: Delta9-FADS-like; cd03505 114615014188 Di-iron ligands [ion binding]; other site 114615014189 The Delta9 Fatty Acid Desaturase (Delta9-FADS)-like CD includes the delta-9 and delta-11 acyl CoA desaturases found in various eukaryotes including vertebrates, insects, higher plants, and fungi. The delta-9 acyl-lipid desaturases are found in a wide...; Region: Delta9-FADS-like; cd03505 114615014190 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cl12011 114615014191 Phytoene dehydrogenase and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG1233 114615014192 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 114615014193 Flp/Fap pilin component; Region: Flp_Fap; cl01585 114615014194 ribosomal protein L11 methyltransferase; Reviewed; Region: prmA; PRK00517 114615014195 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cd02440 114615014196 S-adenosylmethionine binding site [chemical binding]; other site 114615014197 Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321 114615014198 Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006 114615014199 X-Prolyl Aminopeptidase 2. E.C. 3.4.11.9. Also known as X-Pro aminopeptidase, proline aminopeptidase, aminopeptidase P, and aminoacylproline aminopeptidase. Catalyses release of any N-terminal amino acid, including proline, that is linked with proline...; Region: APP; cd01085 114615014200 active site 114615014201 bicyclomycin/multidrug efflux system; Provisional; Region: PRK11102 114615014202 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 114615014203 putative substrate translocation pore; other site 114615014204 NAD-dependent DNA ligase LigA; Validated; Region: ligA; PRK07956 114615014205 NAD+ dependent DNA ligase adenylation domain. DNA ligases catalyze the crucial step of joining the breaks in duplex DNA during DNA replication, repair and recombination, utilizing either ATP or NAD(+) as a cofactor, but using the same basic reaction...; Region: LIGANc; cd00114 114615014206 nucleotide binding pocket [chemical binding]; other site 114615014207 K-X-D-G motif; other site 114615014208 catalytic site [active] 114615014209 NAD-dependent DNA ligase OB-fold domain; Region: DNA_ligase_OB; pfam03120 114615014210 Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo/...; Region: BRCT; cd00027 114615014211 Dimer interface [polypeptide binding]; other site 114615014212 BRCT sequence motif; other site 114615014213 ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: RecN; COG0497 114615014214 RecN ATPase involved in DNA repair; ABC (ATP-binding cassette) transporter nucleotide-binding domain; ABC transporters are a large family of proteins involved in the transport of a wide variety of different compounds including sugars, ions, peptides...; Region: ABC_RecN; cd03241 114615014215 Walker A/P-loop; other site 114615014216 ATP binding site [chemical binding]; other site 114615014217 Q-loop/lid; other site 114615014218 RecN ATPase involved in DNA repair; ABC (ATP-binding cassette) transporter nucleotide-binding domain; ABC transporters are a large family of proteins involved in the transport of a wide variety of different compounds including sugars, ions, peptides...; Region: ABC_RecN; cd03241 114615014219 ABC transporter signature motif; other site 114615014220 Walker B; other site 114615014221 D-loop; other site 114615014222 H-loop/switch region; other site 114615014223 outer membrane assembly lipoprotein YfiO; Region: OM_YfiO; TIGR03302 114615014224 UDP-3-O-acyl-N-acetylglucosamine deacetylase [Cell envelope biogenesis, outer membrane]; Region: LpxC; cl00512 114615014225 UDP-3-O-acyl N-acetylglycosamine deacetylase; Region: LpxC; pfam03331 114615014226 Cell division GTPase [Cell division and chromosome partitioning]; Region: FtsZ; COG0206 114615014227 FtsZ is a GTPase that is similar to the eukaryotic tubulins and is essential for cell division in prokaryotes. FtsZ is capable of polymerizing in a GTP-driven process into structures similar to those formed by tubulin. FtsZ forms a ring-shaped septum...; Region: FtsZ_type1; cd02201 114615014228 nucleotide binding site [chemical binding]; other site 114615014229 SulA interaction site; other site 114615014230 cell division protein FtsZ, alphaProteobacterial C-terminal extension; Region: FtsZ_alphas_C; TIGR03483 114615014231 Cell division ATPase FtsA [Cell division and chromosome partitioning]; Region: ftsA; COG0849 114615014232 Cell division protein FtsA; Region: FtsA; cl11496 114615014233 Cell division protein FtsA; Region: FtsA; cl11496 114615014234 POTRA domain, FtsQ-type; Region: POTRA_1; pfam08478 114615014235 Cell division protein FtsQ; Region: FtsQ; pfam03799 114615014236 D-alanine--D-alanine ligase; Reviewed; Region: ddl; PRK01372 114615014237 D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820 114615014238 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; cl03087 114615014239 UDP-N-acetylenolpyruvoylglucosamine reductase; Provisional; Region: murB; PRK13905 114615014240 FAD binding domain; Region: FAD_binding_4; pfam01565 114615014241 UDP-N-acetylenolpyruvoylglucosamine reductase, C-terminal domain; Region: MurB_C; pfam02873 114615014242 UDP-N-acetylmuramate--L-alanine ligase; Provisional; Region: murC; PRK00421 114615014243 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 114615014244 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 114615014245 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 114615014246 MurG is an N-acetylglucosaminyltransferase, the last enzyme involved in the intracellular phase of peptidoglycan biosynthesis. It transfers N-acetyl-D-glucosamine (GlcNAc) from UDP-GlcNAc to the C4 hydroxyl of a lipid-linked N-acetylmuramoyl...; Region: GT1_MurG; cd03785 114615014247 undecaprenyldiphospho-muramoylpentapeptide beta-N-acetylglucosaminyltransferase; Region: murG; TIGR01133 114615014248 active site 114615014249 homodimer interface [polypeptide binding]; other site 114615014250 Cell cycle protein; Region: FTSW_RODA_SPOVE; cl00511 114615014251 UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase; Provisional; Region: murD; PRK01390 114615014252 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 114615014253 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 114615014254 phospho-N-acetylmuramoyl-pentapeptide-transferase; Provisional; Region: mraY; PRK00108 114615014255 Phospho-N-acetylmuramoyl-pentapeptide-transferase (mraY) is an enzyme responsible for the formation of the first lipid intermediate in the synthesis of bacterial cell wall peptidoglycan. It catalyzes the formation of undecaprenyl-pyrophosphoryl-N-...; Region: GT_MraY; cd06852 114615014256 Mg++ binding site [ion binding]; other site 114615014257 putative catalytic motif [active] 114615014258 putative substrate binding site [chemical binding]; other site 114615014259 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 114615014260 UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D-alanine ligase; Region: murF; TIGR01143 114615014261 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 114615014262 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 114615014263 UDP-N-acetylmuramoylalanyl-D-glutamate--2, 6-diaminopimelate ligase; Provisional; Region: murE; PRK00139 114615014264 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 114615014265 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 114615014266 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 114615014267 Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768 114615014268 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 114615014269 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01039 114615014270 Predicted secreted (periplasmic) protein [Function unknown]; Region: COG5462 114615014271 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cl12011 114615014272 Predicted S-adenosylmethionine-dependent methyltransferase involved in cell envelope biogenesis [Cell envelope biogenesis, outer membrane]; Region: COG0275 114615014273 N-acetyl-anhydromuramyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: ampD; COG3023 114615014274 Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583 114615014275 amidase catalytic site [active] 114615014276 Zn binding residues [ion binding]; other site 114615014277 substrate binding site [chemical binding]; other site 114615014278 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 114615014279 Predicted RNA polymerase sigma factor containing a TPR repeat domain [Transcription]; Region: COG4941 114615014280 YCII-related domain; Region: YCII; cl00999 114615014281 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 114615014282 MsbA is an essential ABC transporter, closely related to eukaryotic MDR proteins. ABC transporters are a large family of proteins involved in the transport of a wide variety of different compounds, like sugars, ions, peptides, and more complex organic...; Region: ABCC_MsbA; cd03251 114615014283 Walker A/P-loop; other site 114615014284 ATP binding site [chemical binding]; other site 114615014285 Q-loop/lid; other site 114615014286 ABC transporter signature motif; other site 114615014287 Walker B; other site 114615014288 D-loop; other site 114615014289 H-loop/switch region; other site 114615014290 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 114615014291 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 114615014292 putative substrate translocation pore; other site 114615014293 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 114615014294 Multidrug resistance efflux pump [Defense mechanisms]; Region: EmrA; COG1566 114615014295 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 114615014296 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 114615014297 nickel responsive regulator; Provisional; Region: PRK02967 114615014298 NikR C terminal nickel binding domain; Region: NikR_C; pfam08753 114615014299 TonB-dependent siderophore receptor; Region: TonB-siderophor; TIGR01783 114615014300 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 114615014301 N-terminal plug; other site 114615014302 ligand-binding site [chemical binding]; other site 114615014303 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3921 114615014304 Extensin-like protein C-terminus; Region: Extensin-like_C; pfam06904 114615014305 Uncharacterized protein conserved in bacteria (DUF2147); Region: DUF2147; cl01951 114615014306 Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices connected by an extended linker. The...; Region: HAMP; cl01054 114615014307 sensor protein RstB; Provisional; Region: PRK10604 114615014308 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 114615014309 ATP binding site [chemical binding]; other site 114615014310 Mg2+ binding site [ion binding]; other site 114615014311 G-X-G motif; other site 114615014312 osmolarity response regulator; Provisional; Region: ompR; PRK09468 114615014313 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156 114615014314 active site 114615014315 phosphorylation site [posttranslational modification] 114615014316 intermolecular recognition site; other site 114615014317 dimerization interface [polypeptide binding]; other site 114615014318 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase...; Region: trans_reg_C; cd00383 114615014319 DNA binding site [nucleotide binding] 114615014320 NodT family; Region: outer_NodT; TIGR01845 114615014321 Outer membrane efflux protein; Region: OEP; pfam02321 114615014322 Outer membrane efflux protein; Region: OEP; pfam02321 114615014323 macrolide transporter subunit MacA; Provisional; Region: PRK11578 114615014324 macrolide transporter ATP-binding /permease protein; Provisional; Region: PRK10535 114615014325 This family is comprised of MJ0796 ATP-binding cassette, macrolide-specific ABC-type efflux carrier (MacAB), and proteins involved in cell division (FtsE), and release of liporoteins from the cytoplasmic membrane (LolCDE). They are clustered together...; Region: ABC_MJ0796_Lo1CDE_FtsE; cd03255 114615014326 Walker A/P-loop; other site 114615014327 ATP binding site [chemical binding]; other site 114615014328 Q-loop/lid; other site 114615014329 ABC transporter signature motif; other site 114615014330 Walker B; other site 114615014331 D-loop; other site 114615014332 H-loop/switch region; other site 114615014333 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 114615014334 FtsX-like permease family; Region: FtsX; pfam02687 114615014335 Protein of unknown function (DUF3313); Region: DUF3313; pfam11769 114615014336 EamA-like transporter family; Region: EamA; cl01037 114615014337 Aerobic-type carbon monoxide dehydrogenase, large subunit CoxL/CutL homologs [Energy production and conversion]; Region: CoxL; COG1529 114615014338 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; cl03161 114615014339 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 114615014340 Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM/CutM homologs [Energy production and conversion]; Region: CoxM; COG1319 114615014341 CO dehydrogenase flavoprotein C-terminal domain; Region: CO_deh_flav_C; cl08390 114615014342 aldehyde oxidoreductase 2Fe-2S subunit; Provisional; Region: PRK11433 114615014343 [2Fe-2S] binding domain; Region: Fer2_2; pfam01799 114615014344 Diadenosine hexaphosphate (Ap6A) hydrolase is a member of the Nudix hydrolase superfamily. Ap6A hydrolase specifically hydrolyzes diadenosine polyphosphates, but not ATP or diadenosine triphosphate, and it generates ATP as the product. Ap6A, the most...; Region: Ap6A_hydrolase; cd03673 114615014345 active site 114615014346 Ap6A binding site [chemical binding]; other site 114615014347 nudix motif; other site 114615014348 metal binding site [ion binding]; metal-binding site 114615014349 terminal organelle assembly protein TopJ; Region: termin_org_DnaJ; TIGR03835 114615014350 Phosphatidylserine decarboxylase; Region: PS_Dcarbxylase; cl03656 114615014351 Glutamate-1-semialdehyde aminotransferase [Coenzyme metabolism]; Region: HemL; COG0001 114615014352 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 114615014353 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 114615014354 catalytic residue [active] 114615014355 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cd02440 114615014356 S-adenosylmethionine binding site [chemical binding]; other site 114615014357 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 114615014358 This family is most closely related to the GT1 family of glycosyltransferases. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule...; Region: GT1_like_2; cd03814 114615014359 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 114615014360 Flp/Fap pilin component; Region: Flp_Fap; cl01585 114615014361 ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683 114615014362 Periplasmic solute-binding domain of active transport proteins that belong to the type I periplasmic binding fold protein family; Region: PBP1_SBP_like_1; cd06327 114615014363 putative ligand binding site [chemical binding]; other site 114615014364 osmolarity response regulator; Provisional; Region: ompR; PRK09468 114615014365 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156 114615014366 active site 114615014367 phosphorylation site [posttranslational modification] 114615014368 intermolecular recognition site; other site 114615014369 dimerization interface [polypeptide binding]; other site 114615014370 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase...; Region: trans_reg_C; cd00383 114615014371 DNA binding site [nucleotide binding] 114615014372 Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices connected by an extended linker. The...; Region: HAMP; cl01054 114615014373 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via trans-...; Region: HisKA; cl00080 114615014374 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 114615014375 ATP binding site [chemical binding]; other site 114615014376 Mg2+ binding site [ion binding]; other site 114615014377 G-X-G motif; other site 114615014378 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic 'goose-type' lysozymes (GEWL). LTs catalyze...; Region: LT_GEWL; cd00254 114615014379 N-acetyl-D-glucosamine binding site [chemical binding]; other site 114615014380 catalytic residue [active] 114615014381 glycine oxidase ThiO; Region: thiamin_ThiO; TIGR02352 114615014382 ThiaminS ubiquitin-like sulfur carrier protein; Region: ThiS; cd00565 114615014383 thiS-thiF/thiG interaction site; other site 114615014384 Thiazole synthase (ThiG) is the tetrameric enzyme that is involved in the formation of the thiazole moiety of thiamin pyrophosphate, an essential ubiquitous cofactor that plays an important role in carbohydrate and amino acid metabolism. ThiG catalyzes...; Region: ThiG; cd04728 114615014385 ThiS interaction site; other site 114615014386 putative active site [active] 114615014387 tetramer interface [polypeptide binding]; other site 114615014388 Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5- (beta-...; Region: TMP_TenI; cd00564 114615014389 active site 114615014390 thiamine phosphate binding site [chemical binding]; other site 114615014391 pyrophosphate binding site [ion binding]; other site 114615014392 ThiC family; Region: ThiC; cl08031 114615014393 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 114615014394 homotrimer interaction site [polypeptide binding]; other site 114615014395 putative active site [active] 114615014396 GST_N family, unknown subfamily 4; composed of uncharacterized bacterial proteins with similarity to GSTs. GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of...; Region: GST_N_4; cd03056 114615014397 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 114615014398 putative C-terminal domain interface [polypeptide binding]; other site 114615014399 putative GSH binding site (G-site) [chemical binding]; other site 114615014400 putative dimer interface [polypeptide binding]; other site 114615014401 C-terminal, alpha helical domain of an unknown subfamily 7 of Glutathione S-transferases; Region: GST_C_7; cd03206 114615014402 putative N-terminal domain interface [polypeptide binding]; other site 114615014403 putative dimer interface [polypeptide binding]; other site 114615014404 putative substrate binding pocket (H-site) [chemical binding]; other site 114615014405 G:T/U mismatch specific DNA glcosylase (MUG); Region: UDG_F2_MUG; cd10028 114615014406 active site 114615014407 SUMO-1 interface [polypeptide binding]; other site 114615014408 Bacterial regulatory protein, Fis family; Region: HTH_8; cl01091 114615014409 Uncharacterized conserved protein (DUF2277); Region: DUF2277; cl02349 114615014410 hypothetical protein; Provisional; Region: PRK06489 114615014411 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 114615014412 Predicted membrane protein [Function unknown]; Region: COG4270 114615014413 Pyridoxine 5'-phosphate (PNP) oxidase-like proteins; Region: PNPOx_like; cl00381 114615014414 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 114615014415 Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2...; Region: Biotinyl_lipoyl_domains; cl11404 114615014416 Putative silver efflux pump [Inorganic ion transport and metabolism]; Region: COG3696 114615014417 Protein of unknown function (DUF3240); Region: DUF3240; pfam11582 114615014418 Bacterioferritin, ferritin-like diiron-binding domain; Region: Bacterioferritin; cd00907 114615014419 Ferritin-like domain; Region: Ferritin; pfam00210 114615014420 heme binding site [chemical binding]; other site 114615014421 ferroxidase pore; other site 114615014422 ferroxidase diiron center [ion binding]; other site 114615014423 BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; cl01093 114615014424 lysozyme_like domain. This contains several members including Soluble Lytic Transglycosylases (SLT), Goose Egg-White Lysozymes (GEWL), Hen Egg-White Lysozymes (HEWL), chitinases, bacteriophage lambda lysozymes, endolysins, autolysins, and chitosanases...; Region: lysozyme_like; cl00222 114615014425 lytic murein transglycosylase; Region: MltB_2; TIGR02283 114615014426 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 114615014427 Uncharacterized protein family, UPF0114; Region: UPF0114; cl01078 114615014428 putative ABC transporter ATP-binding protein; Reviewed; Region: PRK11819 114615014429 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 114615014430 Walker A/P-loop; other site 114615014431 ATP binding site [chemical binding]; other site 114615014432 Q-loop/lid; other site 114615014433 ABC transporter signature motif; other site 114615014434 Walker B; other site 114615014435 D-loop; other site 114615014436 H-loop/switch region; other site 114615014437 ABC transporter; Region: ABC_tran_2; pfam12848 114615014438 ABCF_EF-3 Elongation factor 3 (EF-3) is a cytosolic protein required by fungal ribosomes for in vitro protein synthesis and for in vivo growth. EF-3 stimulates the binding of the EF-1: GTP: aa-tRNA ternary complex to the ribosomal A site by...; Region: ABCF_EF-3; cd03221 114615014439 Lactate dehydrogenase and related dehydrogenases [Energy production and conversion / Coenzyme metabolism / General function prediction only]; Region: LdhA; COG1052 114615014440 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 114615014441 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 114615014442 Thiosulfate sulfurtransferase (TST), N-terminal, inactive domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the 1st repeat, which does not contain the catalytically active Cys residue. The role of the 1st repeat is uncertain, but...; Region: TST_Repeat_1; cd01448 114615014443 3-mercaptopyruvate sulfurtransferase; Provisional; Region: sseA; PRK11493 114615014444 active site residue [active] 114615014445 Thiosulfate sulfurtransferase (TST), C-terminal, catalytic domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the second repeat. Only the second repeat contains the catalytically active Cys residue; Region: TST_Repeat_2; cd01449 114615014446 active site residue [active] 114615014447 Polysulfide-sulfurtransferase - Rhodanese Homology Domain. This domain is believed to serve as a polysulfide binding and transferase domain in anaerobic gram-negative bacteria, functioning in oxidative phosphorylation with polysulfide-sulfur as a...; Region: Polysulfide_ST; cd01447 114615014448 active site 114615014449 catalytic residue [active] 114615014450 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057 114615014451 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 114615014452 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes...; Region: AAA; cd00009 114615014453 Walker A motif; other site 114615014454 ATP binding site [chemical binding]; other site 114615014455 Walker B motif; other site 114615014456 arginine finger; other site 114615014457 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 114615014458 response regulator; Provisional; Region: PRK13435 114615014459 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cl09944 114615014460 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via trans-...; Region: HisKA; cd00082 114615014461 dimer interface [polypeptide binding]; other site 114615014462 phosphorylation site [posttranslational modification] 114615014463 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 114615014464 ATP binding site [chemical binding]; other site 114615014465 Mg2+ binding site [ion binding]; other site 114615014466 G-X-G motif; other site 114615014467 Response regulator receiver domain; Region: Response_reg; pfam00072 114615014468 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156 114615014469 active site 114615014470 phosphorylation site [posttranslational modification] 114615014471 intermolecular recognition site; other site 114615014472 dimerization interface [polypeptide binding]; other site 114615014473 putative diguanylate cyclase; Provisional; Region: PRK09776 114615014474 Motif C-terminal to PAS motifs (likely to contribute to PAS structural domain); Region: PAC; smart00086 114615014475 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 114615014476 PAS fold; Region: PAS_3; pfam08447 114615014477 putative active site [active] 114615014478 heme pocket [chemical binding]; other site 114615014479 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920 114615014480 Histidine kinase; Region: HisKA_2; cl06527 114615014481 HerA helicase [Replication, recombination, and repair]; Region: COG0433 114615014482 Pseudomonas-type; Region: PC_PLC; TIGR03396 114615014483 Sulfatase; Region: Sulfatase; cl10460 114615014484 Domain of unknown function (DUF756); Region: DUF756; pfam05506 114615014485 Domain of unknown function (DUF756); Region: DUF756; pfam05506 114615014486 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via trans-...; Region: HisKA; cd00082 114615014487 dimer interface [polypeptide binding]; other site 114615014488 phosphorylation site [posttranslational modification] 114615014489 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 114615014490 ATP binding site [chemical binding]; other site 114615014491 Mg2+ binding site [ion binding]; other site 114615014492 G-X-G motif; other site 114615014493 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 114615014494 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156 114615014495 active site 114615014496 phosphorylation site [posttranslational modification] 114615014497 intermolecular recognition site; other site 114615014498 dimerization interface [polypeptide binding]; other site 114615014499 OstA-like protein; Region: OstA; cl00844 114615014500 Organic solvent tolerance protein OstA [Cell envelope biogenesis, outer membrane]; Region: Imp; COG1452 114615014501 Organic solvent tolerance protein; Region: OstA_C; pfam04453 114615014502 Cytochrome P450; Region: p450; cl12078 114615014503 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors...; Region: LuxR_C_like; cd06170 114615014504 DNA binding residues [nucleotide binding] 114615014505 dimerization interface [polypeptide binding]; other site 114615014506 ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683 114615014507 Type I periplasmic binding component of ABC (ATPase Binding Cassette)-type transport systems that are predicted to be involved in uptake of amino acids; Region: PBP1_ABC-type_HAAT_like; cd06333 114615014508 putative ligand binding site [chemical binding]; other site 114615014509 choline dehydrogenase; Validated; Region: PRK02106 114615014510 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 114615014511 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 114615014512 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 114615014513 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 114615014514 SMP-30/Gluconolaconase/LRE-like region; Region: SGL; pfam08450 114615014515 Arylesterase; Region: Arylesterase; pfam01731 114615014516 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 114615014517 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 114615014518 Bacterial transcription activator, effector binding domain; Region: AraC_E_bind; cl01368 114615014519 Cupin domain; Region: Cupin_2; cl09118 114615014520 GST_N family, unknown subfamily 1; composed of uncharacterized proteins, predominantly from bacteria, with similarity to GSTs. GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH)...; Region: GST_N_1; cd03043 114615014521 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 114615014522 putative C-terminal domain interface [polypeptide binding]; other site 114615014523 putative GSH binding site (G-site) [chemical binding]; other site 114615014524 putative dimer interface [polypeptide binding]; other site 114615014525 C-terminal, alpha helical domain of an unknown subfamily 3 of Glutathione S-transferases; Region: GST_C_3; cd03194 114615014526 putative N-terminal domain interface [polypeptide binding]; other site 114615014527 putative dimer interface [polypeptide binding]; other site 114615014528 putative substrate binding pocket (H-site) [chemical binding]; other site 114615014529 polyhydroxyalkanoate depolymerase, intracellular; Region: PHB_depoly_PhaZ; TIGR01849 114615014530 PHB de-polymerase C-terminus; Region: PHB_depo_C; cl14907 114615014531 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 114615014532 Cupin domain; Region: Cupin_2; cl09118 114615014533 Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072 114615014534 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 114615014535 Bacterial periplasmic substrate-binding proteins; Region: PBPb; smart00062 114615014536 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and...; Region: PBPb; cd00134 114615014537 substrate binding pocket [chemical binding]; other site 114615014538 membrane-bound complex binding site; other site 114615014539 hinge residues; other site 114615014540 The (Largely Gram-negative Bacterial) Hydrophobe/Amphiphile Efflux-1 (HAE1) Family; Region: 2A0602; TIGR00915 114615014541 Bacterial periplasmic substrate-binding proteins; Region: PBPb; smart00062 114615014542 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and...; Region: PBPb; cd00134 114615014543 substrate binding pocket [chemical binding]; other site 114615014544 membrane-bound complex binding site; other site 114615014545 hinge residues; other site 114615014546 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 114615014547 putative substrate translocation pore; other site 114615014548 Cupin domain; Region: Cupin_2; cl09118 114615014549 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 114615014550 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 114615014551 Malonyl-CoA decarboxylase (MCD); Region: MCD; pfam05292 114615014552 Putative hydrophobic ligand-binding SRPBCC domain of an uncharacterized subgroup of CalC- and Aha1-like proteins; Region: SRPBCC_CalC_Aha1-like_4; cd08897 114615014553 putative hydrophobic ligand binding site [chemical binding]; other site 114615014554 Protein of unknown function (DUF3297); Region: DUF3297; pfam11730 114615014555 Glutathione (GSH) peroxidase family; tetrameric selenoenzymes that catalyze the reduction of a variety of hydroperoxides including lipid peroxidases, using GSH as a specific electron donor substrate. GSH peroxidase contains one selenocysteine residue...; Region: GSH_Peroxidase; cd00340 114615014556 catalytic residues [active] 114615014557 dimer interface [polypeptide binding]; other site 114615014558 amidase; Provisional; Region: PRK07487 114615014559 GGCT-like domains, also called AIG2-like family. Gamma-glutamyl cyclotransferase (GGCT) catalyzes the formation of pyroglutamic acid (5-oxoproline) from dipeptides containing gamma-glutamyl, and is a dimeric protein. In Homo sapiens, the protein is...; Region: GGCT_like; cl11426 114615014560 Lactonase, 7-bladed beta-propeller; Region: Lactonase; pfam10282 114615014561 Truncated hemoglobins (trHbs) are a family of oxygen-binding heme proteins found in cyanobacteria, eubacteria, unicellular eukaryotes, and plants. The truncated hemoglobins have a characteristic two-over-two alpha helical folding pattern that is...; Region: Trunc_globin; cd00454 114615014562 apolar tunnel; other site 114615014563 heme binding site [chemical binding]; other site 114615014564 dimerization interface [polypeptide binding]; other site 114615014565 coenzyme PQQ synthesis protein PqqA; Provisional; Region: pqqA; cl14189 114615014566 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 114615014567 Heme oxygenase catalyzes the rate limiting step in the degradation of heme to bilirubin, it is essential for recycling of iron from heme. Heme is used as a substrate and cofactor for its own degradation to biliverdin, iron, and carbon monoxide. This...; Region: HemeO; cl15243 114615014568 Coenzyme PQQ synthesis protein D (PqqD); Region: PqqD; cl05126 114615014569 pyrroloquinoline quinone biosynthesis protein PqqE; Provisional; Region: PRK05301 114615014570 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster...; Region: Radical_SAM; cd01335 114615014571 FeS/SAM binding site; other site 114615014572 radical SAM additional 4Fe4S-binding domain; Region: rSAM_more_4Fe4S; TIGR04085 114615014573 proline iminopeptidase, Neisseria-type subfamily; Region: pro_imino_pep_1; TIGR01249 114615014574 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 114615014575 putative glutamate synthase (NADPH) small subunit; Provisional; Region: PRK12771 114615014576 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 114615014577 2-oxoacid:acceptor oxidoreductase, alpha subunit; Region: OAFO_sf; TIGR03710 114615014578 Pyruvate ferredoxin/flavodoxin oxidoreductase; Region: POR; cl00546 114615014579 Pyrimidine (PYR) binding domain of pyruvate ferredoxin oxidoreductase (PFOR), indolepyruvate ferredoxin oxidoreductase alpha subunit (IOR-alpha), and related proteins; Region: TPP_PYR_PFOR_IOR-alpha_like; cd07034 114615014580 dimer interface [polypeptide binding]; other site 114615014581 PYR/PP interface [polypeptide binding]; other site 114615014582 TPP binding site [chemical binding]; other site 114615014583 substrate binding site [chemical binding]; other site 114615014584 2-oxoglutarate ferredoxin oxidoreductase subunit beta; Validated; Region: PRK05778 114615014585 Thiamine pyrophosphate (TPP family), 2-oxoglutarate ferredoxin oxidoreductase (OGFOR) subfamily, TPP-binding module; OGFOR catalyzes the oxidative decarboxylation of 2-oxo-acids, with ferredoxin acting as an electron acceptor. In the TCA cycle, OGFOR...; Region: TPP_OGFOR; cd03375 114615014586 TPP-binding site [chemical binding]; other site 114615014587 Pyruvate ferredoxin oxidoreductase beta subunit C terminal; Region: PFO_beta_C; pfam12367 114615014588 Protein of unknown function (DUF3754); Region: DUF3754; pfam12576 114615014589 SpoVR family protein; Provisional; Region: PRK11767 114615014590 Uncharacterized conserved protein [Function unknown]; Region: SpoVR; COG2719 114615014591 Protein of unknown function (DUF444); Region: DUF444; pfam04285 114615014592 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057 114615014593 PrkA family serine protein kinase; Provisional; Region: PRK15455 114615014594 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 114615014595 PrkA serine protein kinase C-terminal domain; Region: PrkA; pfam06798 114615014596 bifunctional transaldolase/phosoglucose isomerase; Validated; Region: PRK09533 114615014597 Transaldolase-like proteins from plants and bacteria; Region: Transaldolase_like; cd00955 114615014598 putative active site [active] 114615014599 catalytic residue [active] 114615014600 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the first SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_1; cd05015 114615014601 active site 114615014602 dimer interface [polypeptide binding]; other site 114615014603 SIS_TAL_PGI: Transaldolase (TAL)/ Phosphoglucose isomerase (PGI). This group represents the SIS (Sugar ISomerase) PGI domain, of a multifunctional protein (TAL-PGI ) having both TAL and PGI activities. TAL_PGI contains an N-terminal TAL domain and a C-...; Region: SIS_TAL_PGI; cd05798 114615014604 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 114615014605 Predicted 6-phosphogluconate dehydrogenase [Carbohydrate transport and metabolism]; Region: Gnd; COG1023 114615014606 glucose-6-phosphate 1-dehydrogenase; Validated; Region: PRK05722 114615014607 Glucose-6-phosphate dehydrogenase, NAD binding domain; Region: G6PD_N; pfam00479 114615014608 Glucose-6-phosphate dehydrogenase, C-terminal domain; Region: G6PD_C; pfam02781 114615014609 6PGL: 6-Phosphogluconolactonase (6PGL) subfamily; 6PGL catalyzes the second step of the oxidative phase of the pentose phosphate pathway, the hydrolyzation of 6-phosphoglucono-1,5-lactone (delta form) to 6-phosphogluconate. 6PGL is thought to guard...; Region: 6PGL; cd01400 114615014610 putative active site [active] 114615014611 Gluconate kinase (GntK) catalyzes the phosphoryl transfer from ATP to gluconate. The resulting product gluconate-6-phoshate is an important precursor of gluconate metabolism. GntK acts as a dimmer composed of two identical subunits; Region: GntK; cd02021 114615014612 Gluconate kinase [Carbohydrate transport and metabolism]; Region: GntK; COG3265 114615014613 ATP-binding site [chemical binding]; other site 114615014614 Gluconate-6-phosphate binding site [chemical binding]; other site 114615014615 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 114615014616 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others...; Region: HAD_like; cl11391 114615014617 Glucoamylase and related glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: SGA1; COG3387 114615014618 Glycosyl hydrolases family 15; Region: Glyco_hydro_15; pfam00723 114615014619 4-alpha-glucanotransferase; Provisional; Region: malQ; PRK11052 114615014620 4-alpha-glucanotransferase; Region: Glyco_hydro_77; cl00711 114615014621 trehalose synthase; Region: treS_nterm; TIGR02456 114615014622 Alpha amylase, catalytic domain; Region: Alpha-amylase; cl07893 114615014623 Uncharacterized protein, probably involved in trehalose biosynthesis [Carbohydrate transport and metabolism]; Region: Ble; cl01286 114615014624 glycogen branching enzyme; Provisional; Region: PRK05402 114615014625 Glycogen branching enzyme N-terminus domain. Glycogen branching enzyme (AKA 1,4 alpha glucan branching enzyme) catalyzes the formation of alpha-1,6 branch points in either glycogen or starch by cleavage of the alpha-1,4 glucosidic linkage yielding a...; Region: Glycogen_branching_enzyme_N_term; cd02855 114615014626 Alpha amylase, catalytic domain; Region: Alpha-amylase; cl07893 114615014627 Alpha amylase, C-terminal all-beta domain; Region: Alpha-amylase_C; cl02706 114615014628 glycogen debranching enzyme GlgX; Region: glgX_debranch; TIGR02100 114615014629 Glycogen_debranching_enzyme N-terminal domain. Glycogen debranching enzymes have both 4-alpha-glucanotransferase and amylo-1,6-glucosidase activities. As a transferase it transfers a segment of a 1,4-alpha-D-glucan to a new 4-position in an acceptor...; Region: Glycogen_debranching_enzyme_N_term; cd02856 114615014630 Alpha amylase, catalytic domain; Region: Alpha-amylase; cl07893 114615014631 Maltooligosyl trehalose synthase (MTSase) N-terminus domain. MTSase and maltooligosyl trehalose trehalohydrolase (MTHase) work together to produce trehalose. MTSase is responsible for converting the alpha-1,4-glucosidic linkage to an alpha,alpha-1,1-...; Region: MTHase_N_term; cd02853 114615014632 malto-oligosyltrehalose trehalohydrolase; Region: trehalose_TreZ; TIGR02402 114615014633 Alpha amylase, catalytic domain; Region: Alpha-amylase; cl07893 114615014634 Domain of unknown function (DUF3459); Region: DUF3459; pfam11941 114615014635 malto-oligosyltrehalose synthase; Region: trehalose_TreY; TIGR02401 114615014636 Alpha amylase, catalytic domain; Region: Alpha-amylase; cl07893 114615014637 Putative polyhydroxyalkanoic acid system protein (PHA_gran_rgn); Region: PHA_gran_rgn; cl09865 114615014638 ATP-dependent DNA ligase; Reviewed; Region: ligD; PRK05972 114615014639 DNA ligase D, 3'-phosphoesterase domain; Region: LigD_PE_dom; TIGR02777 114615014640 Adenylation domain of Mycobacterium tuberculosis LigD and LigC-like ATP-dependent DNA ligases; Region: Adenylation_DNA_ligase_LigD_LigC; cd07906 114615014641 active site 114615014642 DNA binding site [nucleotide binding] 114615014643 The Oligonucleotide/oligosaccharide binding (OB)-fold domain of ATP-dependent DNA ligase LigD is a DNA-binding module that is part of the catalytic core unit; Region: OBF_DNA_ligase_LigD; cd07971 114615014644 DNA binding site [nucleotide binding] 114615014645 PaeLigD_Pol_like: Polymerase (Pol) domain of bacterial LigD proteins similar to Pseudomonas aeruginosa (Pae) LigD. The LigD Pol domain belongs to the archaeal/eukaryal primase (AEP) superfamily. In prokaryotes, LigD along with Ku is required for non-...; Region: PaeLigD_Pol_like; cd04862 114615014646 nucleotide binding site [chemical binding]; other site 114615014647 Ku protein, prokaryotic; Region: Ku_bact; TIGR02772 114615014648 Ku-core domain, Ku-like subfamily; composed of prokaryotic homologs of the eukaryotic DNA binding protein Ku. The alignment includes the core domain shared by the prokaryotic YkoV-like proteins and the eukaryotic Ku70 and Ku80. The prokaryotic Ku...; Region: KU_like; cd00789 114615014649 putative DNA binding site [nucleotide binding]; other site 114615014650 putative homodimer interface [polypeptide binding]; other site 114615014651 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 114615014652 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156 114615014653 active site 114615014654 phosphorylation site [posttranslational modification] 114615014655 intermolecular recognition site; other site 114615014656 dimerization interface [polypeptide binding]; other site 114615014657 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase...; Region: trans_reg_C; cd00383 114615014658 DNA binding site [nucleotide binding] 114615014659 Osmosensitive K+ channel histidine kinase [Signal transduction mechanisms]; Region: KdpD; COG2205 114615014660 Osmosensitive K+ channel His kinase sensor domain; Region: KdpD; pfam02702 114615014661 USP domain is located between the N-terminal sensor domain and C-terminal catalytic domain of this Osmosensitive K+ channel histidine kinase family. The family of KdpD sensor kinase proteins regulates the kdpFABC operon responsible for potassium...; Region: USP_OKCHK; cd01987 114615014662 Ligand Binding Site [chemical binding]; other site 114615014663 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via trans-...; Region: HisKA; cd00082 114615014664 dimer interface [polypeptide binding]; other site 114615014665 phosphorylation site [posttranslational modification] 114615014666 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 114615014667 ATP binding site [chemical binding]; other site 114615014668 Mg2+ binding site [ion binding]; other site 114615014669 G-X-G motif; other site 114615014670 K+-transporting ATPase, c chain; Region: KdpC; cl00944 114615014671 potassium-transporting ATPase subunit B; Provisional; Region: PRK01122 114615014672 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 114615014673 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others...; Region: HAD_like; cl11391 114615014674 K+-transporting ATPase, A chain [Inorganic ion transport and metabolism]; Region: KdpA; cl00903 114615014675 Potassium-transporting ATPase A subunit; Region: KdpA; pfam03814 114615014676 Oxalate/Formate Antiporter; Region: 2A0111; TIGR00890 114615014677 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 114615014678 SirA, YedF, and YeeD. Two-layered alpha/beta sandwich domain. SirA (also known as UvrY, and YhhP) belongs to a family of bacterial two-component response regulators that controls secondary metabolism and virulence. The other member of this two-...; Region: SirA_YedF_YeeD; cd00291 114615014679 CPxP motif; other site 114615014680 Molybdenum is an essential trace element in the form of molybdenum cofactor (Moco) which is associated with the metabolism of nitrogen, carbon and sulfur by redox active enzymes. In E. coli, the synthesis of Moco involves genes from several loci: moa...; Region: MobB; cd03116 114615014681 Walker A motif; other site 114615014682 MobA catalyzes the formation of molybdopterin guanine dinucleotide; Region: MobA; cd02503 114615014683 GTP binding site [chemical binding]; other site 114615014684 Cation efflux family; Region: Cation_efflux; cl00316 114615014685 ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683 114615014686 Periplasmic solute-binding domain of active transport proteins that belong to the type I periplasmic binding fold protein family; Region: PBP1_SBP_like_1; cd06327 114615014687 putative ligand binding site [chemical binding]; other site 114615014688 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3181 114615014689 Tripartite tricarboxylate transporter family receptor; Region: TctC; cl15260 114615014690 DNA or RNA helicases of superfamily II [Transcription / DNA replication, recombination, and repair]; Region: SSL2; COG1061 114615014691 AE_Prim_S_like: primase domain similar to that found in the small subunit of archaeal and eukaryotic (A/E) DNA primases. The replication machineries of A/Es are distinct from that of bacteria. Primases are DNA-dependent RNA polymerases which synthesis...; Region: AE_Prim_S_like; cl01287 114615014692 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 114615014693 ATP binding site [chemical binding]; other site 114615014694 putative Mg++ binding site [ion binding]; other site 114615014695 Nucleotidyl transferase of unknown function (DUF1814); Region: DUF1814; cl00973 114615014696 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084 114615014697 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 114615014698 Carboxymuconolactone decarboxylase family; Region: CMD; cl00460 114615014699 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 114615014700 Uncharacterized Saccharopolyspora spinosa aldehyde dehydrogenase (AAS00426)-like; Region: ALDH_AAS00426; cd07109 114615014701 NAD(P) binding site [chemical binding]; other site 114615014702 catalytic residues [active] 114615014703 catalytic residues [active] 114615014704 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410 114615014705 LivF (TM1139) is part of the LIV-I bacterial ABC-type two-component transport system that imports neutral, branched-chain amino acids. The E. coli branched-chain amino acid transporter comprises a heterodimer of ABC transporters (LivF and LivG), a...; Region: ABC_TM1139_LivF_branched; cd03224 114615014706 Walker A/P-loop; other site 114615014707 ATP binding site [chemical binding]; other site 114615014708 Q-loop/lid; other site 114615014709 ABC transporter signature motif; other site 114615014710 Walker B; other site 114615014711 D-loop; other site 114615014712 H-loop/switch region; other site 114615014713 ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683 114615014714 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 114615014715 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 114615014716 TM-ABC transporter signature motif; other site 114615014717 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 114615014718 TM-ABC transporter signature motif; other site 114615014719 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411 114615014720 The Mj1267/LivG ABC transporter subfamily is involved in the transport of the hydrophobic amino acids leucine, isoleucine and valine. MJ1267 is a branched-chain amino acid transporter with 29% similarity to both the LivF and LivG components of the E...; Region: ABC_Mj1267_LivG_branched; cd03219 114615014721 Walker A/P-loop; other site 114615014722 ATP binding site [chemical binding]; other site 114615014723 Q-loop/lid; other site 114615014724 ABC transporter signature motif; other site 114615014725 Walker B; other site 114615014726 D-loop; other site 114615014727 H-loop/switch region; other site 114615014728 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459 114615014729 PAS fold; Region: PAS_4; pfam08448 114615014730 Motif C-terminal to PAS motifs (likely to contribute to PAS structural domain); Region: PAC; smart00086 114615014731 sensor protein ZraS; Provisional; Region: PRK10364 114615014732 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 114615014733 ATP binding site [chemical binding]; other site 114615014734 Mg2+ binding site [ion binding]; other site 114615014735 G-X-G motif; other site 114615014736 Response regulator receiver domain; Region: Response_reg; pfam00072 114615014737 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156 114615014738 active site 114615014739 phosphorylation site [posttranslational modification] 114615014740 intermolecular recognition site; other site 114615014741 dimerization interface [polypeptide binding]; other site 114615014742 Predicted homoserine dehydrogenase [Amino acid transport and metabolism]; Region: COG4091 114615014743 AAA domain (dynein-related subfamily); Region: AAA_5; pfam07728 114615014744 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 114615014745 CbbQ/NirQ/NorQ C-terminal; Region: CbbQ_C; pfam08406 114615014746 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057 114615014747 metal ion-dependent adhesion site (MIDAS); other site 114615014748 UreD urease accessory protein; Region: UreD; cl00530 114615014749 Ras-like GTPase superfamily. The Ras-like superfamily of small GTPases consists of several families with an extremely high degree of structural and functional similarity. The Ras superfamily is divided into at least four families in eukaryotes: the Ras...; Region: Ras_like_GTPase; cl10444 114615014750 urease subunit alpha; Reviewed; Region: ureC; PRK13308 114615014751 Urease alpha-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, fungi and plants. Their primary role is to allow the use of...; Region: Urease_alpha; cd00375 114615014752 subunit interactions [polypeptide binding]; other site 114615014753 active site 114615014754 flap region; other site 114615014755 bifunctional urease subunit gamma/beta; Reviewed; Region: PRK13192 114615014756 Urease gamma-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, archaea, fungi and plants. Their primary role is to allow the use...; Region: Urease_gamma; cd00390 114615014757 alpha-gamma subunit interface [polypeptide binding]; other site 114615014758 beta-gamma subunit interface [polypeptide binding]; other site 114615014759 Urease beta-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, archaea, fungi and plants. Their primary role is to allow the use...; Region: Urease_beta; cd00407 114615014760 alpha-beta subunit interface [polypeptide binding]; other site 114615014761 Urease accessory protein UreF [Posttranslational modification, protein turnover, chaperones]; Region: UreF; COG0830 114615014762 UreF; Region: UreF; pfam01730 114615014763 UreE urease accessory protein. UreE is a metallochaperone assisting the insertion of a Ni2+ ion in the active site of urease, an important step in the in vivo assembly of urease, an enzyme that hydrolyses urea into ammonia and carbamic acid. The C-...; Region: UreE; cl03727 114615014764 dimer interface [polypeptide binding]; other site 114615014765 catalytic residues [active] 114615014766 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 114615014767 Homoserine acetyltransferase [Amino acid transport and metabolism]; Region: MET2; COG2021 114615014768 Purine-cytosine permease and related proteins [Nucleotide transport and metabolism]; Region: CodB; COG1457 114615014769 Sodium:solute symporter family; Region: SSF; cl00456 114615014770 aliphatic amidases (class 2 nitrilases); Region: aliphatic_amidase; cd07565 114615014771 Predicted amidohydrolase [General function prediction only]; Region: COG0388 114615014772 multimer interface [polypeptide binding]; other site 114615014773 active site 114615014774 catalytic triad [active] 114615014775 dimer interface [polypeptide binding]; other site 114615014776 urea ABC transporter, ATP-binding protein UrtE; Region: urea_trans_UrtE; TIGR03410 114615014777 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 114615014778 Walker A/P-loop; other site 114615014779 ATP binding site [chemical binding]; other site 114615014780 Q-loop/lid; other site 114615014781 ABC transporter signature motif; other site 114615014782 Walker B; other site 114615014783 D-loop; other site 114615014784 H-loop/switch region; other site 114615014785 urea ABC transporter, ATP-binding protein UrtD; Region: urea_trans_UrtD; TIGR03411 114615014786 The Mj1267/LivG ABC transporter subfamily is involved in the transport of the hydrophobic amino acids leucine, isoleucine and valine. MJ1267 is a branched-chain amino acid transporter with 29% similarity to both the LivF and LivG components of the E...; Region: ABC_Mj1267_LivG_branched; cd03219 114615014787 Walker A/P-loop; other site 114615014788 ATP binding site [chemical binding]; other site 114615014789 Q-loop/lid; other site 114615014790 ABC transporter signature motif; other site 114615014791 Walker B; other site 114615014792 D-loop; other site 114615014793 H-loop/switch region; other site 114615014794 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 114615014795 TM-ABC transporter signature motif; other site 114615014796 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 114615014797 TM-ABC transporter signature motif; other site 114615014798 ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683 114615014799 Type I periplasmic components of amide-binding protein (AmiC) and the active transport system for short-chain and urea (FmdDEF); Region: PBP1_AmiC_like; cd06331 114615014800 ligand binding site [chemical binding]; other site 114615014801 Response regulator with putative antiterminator output domain [Signal transduction mechanisms]; Region: AmiR; COG3707 114615014802 ANTAR domain; Region: ANTAR; cl04297 114615014803 ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683 114615014804 Periplasmic binding domain of amidase (AmiC) that belongs to the type I periplasmic binding fold protein family; Region: PBP1_AmiC; cd06357 114615014805 ligand binding site [chemical binding]; other site 114615014806 regulator interaction site; other site 114615014807 Transcriptional regulator containing an amidase domain and an AraC-type DNA-binding HTH domain [Transcription]; Region: COG4977 114615014808 AraC transcriptional regulators having an N-terminal Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GATase1_AraC_ArgR_like; cd03136 114615014809 conserved cys residue [active] 114615014810 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 114615014811 sarcosine oxidase, beta subunit family, heterotetrameric form; Region: soxB; TIGR01373 114615014812 Malate:quinone oxidoreductase (Mqo); Region: Mqo; cl14881 114615014813 Sarcosine oxidase, delta subunit family; Region: SoxD; cl01767 114615014814 sarcosine oxidase, alpha subunit family, heterotetrameric form; Region: soxA; TIGR01372 114615014815 Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669 114615014816 Sarcosine oxidase, gamma subunit family; Region: SoxG; cl01893 114615014817 glutamine synthetase, type III; Region: gln_synth_III; TIGR03105 114615014818 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 114615014819 Glutamate synthase (GltS) FMN-binding domain. GltS is a complex iron-sulfur flavoprotein that catalyzes the reductive synthesis of L-glutamate from 2-oxoglutarate and L-glutamine via intramolecular channelling of ammonia, a reaction in the plant...; Region: GltS_FMN; cd02808 114615014820 Conserved region in glutamate synthase; Region: Glu_synthase; pfam01645 114615014821 active site 114615014822 FMN binding site [chemical binding]; other site 114615014823 substrate binding site [chemical binding]; other site 114615014824 3Fe-4S cluster binding site [ion binding]; other site 114615014825 GXGXG domain. This domain of unknown function is found at the C-terminus of the large subunit (gltB) of glutamate synthase (GltS), in subunit C of tungsten formylmethanofuran dehydrogenase (FwdC) and in subunit C of molybdenum formylmethanofuran...; Region: GXGXG; cd00504 114615014826 domain_subunit interface; other site 114615014827 Glutamine amidotransferases class-II (GATase). The glutaminase domain catalyzes an amide nitrogen transfer from glutamine to the appropriate substrate. In this process, glutamine is hydrolyzed to glutamic acid and ammonia. This domain is related to...; Region: Gn_AT_II; cl00319 114615014828 Glutamine amidotransferases class-II (Gn-AT)_GlxB-type. GlxB is a glutamine amidotransferase-like protein of unknown function found in bacteria and archaea. GlxB has a structural fold similar to that of other class II glutamine amidotransferases...; Region: GlxB; cd01907 114615014829 putative active site [active] 114615014830 Cupin domain; Region: Cupin_2; cl09118 114615014831 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cd02440 114615014832 S-adenosylmethionine binding site [chemical binding]; other site 114615014833 Predicted tRNA(5-methylaminomethyl-2-thiouridylate) methyltransferase, contains the PP-loop ATPase domain [Translation, ribosomal structure and biogenesis]; Region: TrmU; COG0482 114615014834 tRNA methyl transferase. This family represents tRNA(5-methylaminomethyl-2-thiouridine)-methyltransferase which is involved in the biosynthesis of the modified nucleoside 5-methylaminomethyl-2-thiouridine present in the wobble position of some tRNAs...; Region: tRNA_Me_trans; cd01998 114615014835 Ligand Binding Site [chemical binding]; other site 114615014836 Flagellar hook-length control protein FliK; Region: Flg_hook; cl15269 114615014837 Flagellar hook capping protein; Region: FlgD; cl04347 114615014838 Protein of unknown function (DUF1153); Region: DUF1153; pfam06627 114615014839 flagellar MS-ring protein; Reviewed; Region: fliF; PRK06007 114615014840 Secretory protein of YscJ/FliF family; Region: YscJ_FliF; cl01907 114615014841 Flagellar M-ring protein C-terminal; Region: YscJ_FliF_C; pfam08345 114615014842 flagellar motor switch protein G; Validated; Region: fliG; PRK05686 114615014843 MgtE intracellular N domain; Region: MgtE_N; cl15244 114615014844 FliG C-terminal domain; Region: FliG_C; pfam01706 114615014845 flagellar assembly protein H; Validated; Region: fliH; PRK06032 114615014846 Flagellar assembly protein FliH; Region: FliH; pfam02108 114615014847 Surface presentation of antigens (SPOA); Region: SpoA; cl00819 114615014848 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204 114615014849 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes...; Region: AAA; cd00009 114615014850 Walker A motif; other site 114615014851 ATP binding site [chemical binding]; other site 114615014852 Walker B motif; other site 114615014853 arginine finger; other site 114615014854 Bacterial regulatory protein, Fis family; Region: HTH_8; cl01091 114615014855 Autotransporter beta-domain; Region: Autotransporter; cl02365 114615014856 Surface antigen; Region: Surface_Ag_2; cl01155 114615014857 Caspase, interleukin-1 beta converting enzyme (ICE) homologues; Cysteine-dependent aspartate-directed proteases that mediate programmed cell death (apoptosis). Caspases are synthesized as inactive zymogens and activated by proteolysis of the peptide...; Region: CASc; cl00042 114615014858 Flavin Reductases; Region: FlaRed; cl00801 114615014859 aliphatic sulfonates transport ATP-binding subunit; Provisional; Region: ssuB; PRK11247 114615014860 NrtD and SsuB are the ATP-binding subunits of the bacterial ABC-type nitrate and sulfonate transport systems, respectively. ABC transporters are a large family of proteins involved in the transport of a wide variety of different compounds, like sugars...; Region: ABC_NrtD_SsuB_transporters; cd03293 114615014861 Walker A/P-loop; other site 114615014862 ATP binding site [chemical binding]; other site 114615014863 Q-loop/lid; other site 114615014864 ABC transporter signature motif; other site 114615014865 Walker B; other site 114615014866 D-loop; other site 114615014867 H-loop/switch region; other site 114615014868 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 114615014869 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261 114615014870 dimer interface [polypeptide binding]; other site 114615014871 conserved gate region; other site 114615014872 putative PBP binding loops; other site 114615014873 ABC-ATPase subunit interface; other site 114615014874 Alkanesulfonate monoxygenase is the monoxygenase of a two-component system that catalyzes the conversion of alkanesulfonates to the corresponding aldehyde and sulfite. Alkanesulfonate monoxygenase (SsuD) has an absolute requirement for reduced flavin...; Region: Alkanesulfonate_monoxygenase; cd01094 114615014875 active site 114615014876 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases [Energy production and conversion]; Region: COG2141 114615014877 dimer interface [polypeptide binding]; other site 114615014878 non-prolyl cis peptide bond; other site 114615014879 insertion regions; other site 114615014880 ABC transporter, substrate-binding protein, aliphatic sulfonates family; Region: SsuA_fam; TIGR01728 114615014881 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and...; Region: PBPb; cd00134 114615014882 substrate binding pocket [chemical binding]; other site 114615014883 membrane-bound complex binding site; other site 114615014884 hinge residues; other site 114615014885 Periplasmic nitrate reductase protein NapE; Region: NapE; cl01848 114615014886 NapD protein; Region: NapD; cl01163 114615014887 nitrate reductase catalytic subunit; Provisional; Region: PRK13532 114615014888 NasA, and NarB catalyze the reduction of nitrate to nitrite. Monomeric Nas is located in the cytoplasm and participates in nitrogen assimilation. Dimeric Nap is located in the periplasm and is coupled to quinol oxidation via a membrane-anchored...; Region: MopB_Nitrate-R-NapA-like; cd02754 114615014889 [4Fe-4S] binding site [ion binding]; other site 114615014890 molybdopterin cofactor binding site; other site 114615014891 NasA, and NarB catalyze the reduction of nitrate to nitrite. Monomeric Nas is located in the cytoplasm and participates in nitrogen assimilation. Dimeric Nap is located in the periplasm and is coupled to quinol oxidation via a membrane-anchored...; Region: MopB_CT_Nitrate-R-NapA-like; cd02791 114615014892 molybdopterin cofactor binding site; other site 114615014893 Nitrate reductase cytochrome c-type subunit (NapB); Region: NapB; cl01153 114615014894 cytochrome c-type protein NapC; Provisional; Region: PRK10617; cl09485 114615014895 ATP-dependent exoDNAse (exonuclease V), alpha subunit - helicase superfamily I member [DNA replication, recombination, and repair]; Region: RecD; COG0507 114615014896 UvrD/REP helicase; Region: UvrD-helicase; cl14126 114615014897 Uncharacterized conserved protein [Function unknown]; Region: COG2326 114615014898 Polyphosphate kinase 2 (PPK2); Region: PPK2; cl11971 114615014899 Transposase domain (DUF772); Region: DUF772; cl12084 114615014900 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 114615014901 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi...; Region: TPR; cd00189 114615014902 binding surface 114615014903 TPR motif; other site 114615014904 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi...; Region: TPR; cd00189 114615014905 binding surface 114615014906 TPR motif; other site 114615014907 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi...; Region: TPR; cd00189 114615014908 binding surface 114615014909 TPR motif; other site 114615014910 tetratricopeptide repeat protein; Provisional; Region: PRK11788 114615014911 Caspase, interleukin-1 beta converting enzyme (ICE) homologues; Cysteine-dependent aspartate-directed proteases that mediate programmed cell death (apoptosis). Caspases are synthesized as inactive zymogens and activated by proteolysis of the peptide...; Region: CASc; cl00042 114615014912 Peptide methionine sulfoxide reductase; Region: PMSR; cl00366 114615014913 SelR domain; Region: SelR; cl00369 114615014914 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 114615014915 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 114615014916 adenylosuccinate synthetase; Provisional; Region: PRK01117 114615014917 Adenylosuccinate synthetase (AdSS) catalyzes the first step in the de novo biosynthesis of AMP. IMP and L-aspartate are conjugated in a two-step reaction accompanied by the hydrolysis of GTP to GDP in the presence of Mg2+. In the first step, the r-...; Region: AdSS; cd03108 114615014918 GDP-binding site [chemical binding]; other site 114615014919 ACT binding site; other site 114615014920 IMP binding site; other site 114615014921 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 114615014922 This family is comprised of MJ0796 ATP-binding cassette, macrolide-specific ABC-type efflux carrier (MacAB), and proteins involved in cell division (FtsE), and release of liporoteins from the cytoplasmic membrane (LolCDE). They are clustered together...; Region: ABC_MJ0796_Lo1CDE_FtsE; cd03255 114615014923 Walker A/P-loop; other site 114615014924 ATP binding site [chemical binding]; other site 114615014925 Q-loop/lid; other site 114615014926 ABC transporter signature motif; other site 114615014927 Walker B; other site 114615014928 D-loop; other site 114615014929 H-loop/switch region; other site 114615014930 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 114615014931 FtsX-like permease family; Region: FtsX; pfam02687 114615014932 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 114615014933 Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2...; Region: Biotinyl_lipoyl_domains; cl11404 114615014934 Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; cl02930 114615014935 magnesium-translocating P-type ATPase; Region: ATPase-IIIB_Mg; TIGR01524 114615014936 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 114615014937 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others...; Region: HAD_like; cl11391 114615014938 Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689 114615014939 EamA-like transporter family; Region: EamA; cl01037 114615014940 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 114615014941 EamA-like transporter family; Region: EamA; cl01037 114615014942 EamA-like transporter family; Region: EamA; cl01037 114615014943 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 114615014944 EamA-like transporter family; Region: EamA; cl01037 114615014945 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4222 114615014946 Cache domain; Region: Cache_2; cl07034 114615014947 Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices connected by an extended linker. The...; Region: HAMP; cl01054 114615014948 Taxis toward Aspartate and Related amino acids and Homologs (TarH). The Tar chemoreceptor of Escherichia coli mediates attractant responses to aspartate, maltose, and phenol, repellent responses to Ni2+ and Co2+, and thermoresponses. These...; Region: TarH; cl00144 114615014949 FtsH Extracellular; Region: FtsH_ext; pfam06480 114615014950 ATP-dependent metalloprotease FtsH; Region: FtsH_fam; TIGR01241 114615014951 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 114615014952 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes...; Region: AAA; cd00009 114615014953 Walker A motif; other site 114615014954 ATP binding site [chemical binding]; other site 114615014955 Walker B motif; other site 114615014956 arginine finger; other site 114615014957 Peptidase family M41; Region: Peptidase_M41; pfam01434 114615014958 ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683 114615014959 Type I periplasmic binding domain of uncharacterized extracellular ligand-binding proteins; Region: PBP1_STKc_like; cd06326 114615014960 putative ligand binding site [chemical binding]; other site 114615014961 conserved hypothetical protein; Region: TIGR02231 114615014962 D-3-phosphoglycerate dehydrogenase; Provisional; Region: PRK13581 114615014963 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 114615014964 C-terminal ACT (regulatory) domain of D-3-phosphoglycerate dehydrogenase (3PGDH); Region: ACT_3PGDH-xct; cd04902 114615014965 putative L-serine binding site [chemical binding]; other site 114615014966 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cd01494 114615014967 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 114615014968 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 114615014969 catalytic residue [active] 114615014970 Predicted oxidoreductases (related to aryl-alcohol dehydrogenases) [Energy production and conversion]; Region: Tas; COG0667 114615014971 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and...; Region: Aldo_ket_red; cd06660 114615014972 active site 114615014973 catalytic tetrad [active] 114615014974 Predicted metal-dependent hydrolase of the TIM-barrel fold [General function prediction only]; Region: COG3618 114615014975 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have...; Region: metallo-dependent_hydrolases; cl00281 114615014976 active site 114615014977 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 114615014978 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 114615014979 Coenzyme A binding pocket [chemical binding]; other site 114615014980 Surface antigen; Region: Surface_Ag_2; cl01155 114615014981 phosphoglucosamine mutase; Provisional; Region: glmM; PRK14315 114615014982 GlmM is a bacterial phosphoglucosamine mutase (PNGM) that belongs to the alpha-D-phosphohexomutase superfamily. It is required for the interconversion of glucosamine-6-phosphate and glucosamine-1-phosphate in the biosynthetic pathway of UDP-N-...; Region: GlmM; cd05802 114615014983 active site 114615014984 substrate binding site [chemical binding]; other site 114615014985 metal binding site [ion binding]; metal-binding site 114615014986 L-lactate dehydrogenase; Provisional; Region: lldD; PRK11197 114615014987 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl09108 114615014988 phosphate binding site [ion binding]; other site 114615014989 shikimate 5-dehydrogenase; Reviewed; Region: aroE; PRK00258 114615014990 Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501 114615014991 NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065 114615014992 shikimate binding site; other site 114615014993 NAD(P) binding site [chemical binding]; other site 114615014994 Protein of unknown function (DUF1275); Region: DUF1275; cl01453 114615014995 putative transporter; Provisional; Region: PRK11660 114615014996 Sulfate transporter family; Region: Sulfate_transp; cl00967 114615014997 Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function; Region: STAS_SulP_like_sulfate_transporter; cd07042 114615014998 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl15258 114615014999 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920 114615015000 Histidine kinase; Region: HisKA_2; cl06527 114615015001 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 114615015002 ATP binding site [chemical binding]; other site 114615015003 Mg2+ binding site [ion binding]; other site 114615015004 G-X-G motif; other site 114615015005 haemagglutination activity domain; Region: Haemagg_act; cl05436 114615015006 Pertactin-like passenger domains (virulence factors) of autotransporter proteins of the type V secretion system. Autotransporters are proteins used by Gram-negative bacteria to transport proteins across their outer membranes. The C-terminal (beta)...; Region: PL_Passenger_AT; cl00185 114615015007 AIDA autotransporter-like protein ShdA; Provisional; Region: PRK15319 114615015008 Pertactin-like passenger domains (virulence factors) of autotransporter proteins of the type V secretion system. Autotransporters are proteins used by Gram-negative bacteria to transport proteins across their outer membranes. The C-terminal (beta)...; Region: PL_Passenger_AT; cl00185 114615015009 putative lipoprotein/autotransporter domain-containing protein; Provisional; Region: PRK14849 114615015010 haemagglutination activity domain; Region: Haemagg_act; cl05436 114615015011 Surface antigen; Region: Bac_surface_Ag; cl03097 114615015012 Elongation factor G (EF-G) subfamily. Translocation is mediated by EF-G (also called translocase). The structure of EF-G closely resembles that of the complex between EF-Tu and tRNA. This is an example of molecular mimicry; a protein domain evolved...; Region: EF-G_bact; cd04170 114615015013 elongation factor G; Reviewed; Region: PRK12740 114615015014 G1 box; other site 114615015015 putative GEF interaction site [polypeptide binding]; other site 114615015016 GTP/Mg2+ binding site [chemical binding]; other site 114615015017 Switch I region; other site 114615015018 G2 box; other site 114615015019 G3 box; other site 114615015020 Switch II region; other site 114615015021 G4 box; other site 114615015022 G5 box; other site 114615015023 EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide...; Region: EFG_mtEFG_II; cd04088 114615015024 EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor...; Region: EFG_mtEFG1_IV; cd01434 114615015025 EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G. Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor...; Region: EFG_mtEFG_C; cd03713 114615015026 Protein of unknown function (DUF992); Region: DUF992; pfam06186 114615015027 Protein of unknown function (DUF992); Region: DUF992; pfam06186 114615015028 hypothetical protein; Validated; Region: PRK07682 114615015029 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 114615015030 pyridoxal 5'-phosphate binding site [chemical binding]; other site 114615015031 homodimer interface [polypeptide binding]; other site 114615015032 catalytic residue [active] 114615015033 Protein of unknown function (DUF2029); Region: DUF2029; cl09812 114615015034 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 114615015035 GST_N family, unknown subfamily 4; composed of uncharacterized bacterial proteins with similarity to GSTs. GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of...; Region: GST_N_4; cd03056 114615015036 putative C-terminal domain interface [polypeptide binding]; other site 114615015037 putative GSH binding site (G-site) [chemical binding]; other site 114615015038 putative dimer interface [polypeptide binding]; other site 114615015039 C-terminal, alpha helical domain of the Glutathione S-transferase family; Region: GST_C_family; cl02776 114615015040 N-terminal domain interface [polypeptide binding]; other site 114615015041 dimer interface [polypeptide binding]; other site 114615015042 substrate binding pocket (H-site) [chemical binding]; other site 114615015043 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 114615015044 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 114615015045 Coenzyme A binding pocket [chemical binding]; other site 114615015046 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 114615015047 Domain of unknown function DUF20; Region: UPF0118; cl00465 114615015048 Antibiotic biosynthesis monooxygenase; Region: ABM; cl10022 114615015049 Protein of unknown function (DUF1501); Region: DUF1501; cl01699 114615015050 Protein of unknown function (DUF1800); Region: DUF1800; pfam08811 114615015051 beta-phosphoglucomutase family hydrolase; Region: PGMB-YQAB-SF; TIGR02009 114615015052 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others...; Region: HAD_like; cd01427 114615015053 motif II; other site 114615015054 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 114615015055 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 114615015056 enoyl-CoA hydratase; Provisional; Region: PRK05980 114615015057 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase...; Region: crotonase-like; cd06558 114615015058 substrate binding site [chemical binding]; other site 114615015059 oxyanion hole (OAH) forming residues; other site 114615015060 trimer interface [polypeptide binding]; other site 114615015061 GST_N family, Beta etherase LigE subfamily; composed of proteins similar to Sphingomonas paucimobilis beta etherase, LigE, a GST-like protein that catalyzes the cleavage of the beta-aryl ether linkages present in low-moleculer weight lignins using GSH...; Region: GST_N_etherase_LigE; cd03038 114615015062 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 114615015063 putative C-terminal domain interface [polypeptide binding]; other site 114615015064 putative GSH binding site (G-site) [chemical binding]; other site 114615015065 putative dimer interface [polypeptide binding]; other site 114615015066 C-terminal, alpha helical domain of Beta etherase LigE; Region: GST_C_etherase_LigE; cd03202 114615015067 putative dimer interface [polypeptide binding]; other site 114615015068 putative substrate binding pocket (H-site) [chemical binding]; other site 114615015069 putative N-terminal domain interface [polypeptide binding]; other site 114615015070 DNA-binding transcriptional activator GcvA; Provisional; Region: PRK11139 114615015071 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 114615015072 HvR and beta-lactamase regulators, and that of other closely related homologs; contains the type 2 periplasmic binding fold; Region: PBP2_GcdR_TrpI_HvrB_AmpR_like; cd08432 114615015073 dimerization interface [polypeptide binding]; other site 114615015074 substrate binding pocket [chemical binding]; other site 114615015075 excinuclease ABC subunit B; Provisional; Region: PRK05298 114615015076 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 114615015077 ATP binding site [chemical binding]; other site 114615015078 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 114615015079 nucleotide binding region [chemical binding]; other site 114615015080 ATP-binding site [chemical binding]; other site 114615015081 Ultra-violet resistance protein B; Region: UvrB; pfam12344 114615015082 UvrB/uvrC motif; Region: UVR; pfam02151 114615015083 hypothetical protein; Provisional; Region: PRK00183 114615015084 SEC-C motif; Region: SEC-C; cl12132 114615015085 Phosphoribosylpyrophosphate synthetase [Nucleotide transport and metabolism / Amino acid transport and metabolism]; Region: PrsA; COG0462 114615015086 Phosphoribosyl transferase domain; Region: Pribosyltran; cl00309 114615015087 Multicopper polyphenol oxidase (laccase) [Secondary metabolites biosynthesis, transport and catabolism]; Region: yfiH; COG1496 114615015088 Multi-copper polyphenol oxidoreductase laccase; Region: Cu-oxidase_4; cl00650 114615015089 Uncharacterized conserved protein [Function unknown]; Region: COG1565 114615015090 Uncharacterized ACR, COG1565; Region: DUF185; pfam02636 114615015091 Prolipoprotein diacylglyceryl transferase; Region: LGT; cl00478 114615015092 Membrane fusogenic activity; Region: BMFP; cl01115 114615015093 50S ribosomal protein L25/general stress protein Ctc; Reviewed; Region: PRK05618 114615015094 Ribosomal L25/TL5/CTC N-terminal 5S rRNA binding domain; Region: Ribosomal_L25_TL5_CTC; cd00495 114615015095 CTC domain interface [polypeptide binding]; other site 114615015096 L16 interface [polypeptide binding]; other site 114615015097 Peptidyl-tRNA hydrolase (PTH) is a monomeric protein that cleaves the ester bond linking the nascent peptide and tRNA when peptidyl-tRNA is released prematurely from the ribosome. This ensures the recycling of peptidyl-tRNAs into tRNAs produced through...; Region: PTH; cd00462 114615015098 putative active site [active] 114615015099 catalytic residue [active] 114615015100 GTP-binding protein YchF; Reviewed; Region: PRK09601 114615015101 YchF subfamily. YchF is a member of the Obg family, which includes four other subfamilies of GTPases: Obg, DRG, Ygr210, and NOG1. Obg is an essential gene that is involved in DNA replication in C. crescentus and Streptomyces griseus and is associated...; Region: YchF; cd01900 114615015102 G1 box; other site 114615015103 GTP/Mg2+ binding site [chemical binding]; other site 114615015104 Switch I region; other site 114615015105 G2 box; other site 114615015106 Switch II region; other site 114615015107 G3 box; other site 114615015108 G4 box; other site 114615015109 G5 box; other site 114615015110 TGS_YchF_C: This subfamily represents TGS domain-containing YchF GTP-binding protein, a universally conserved GTPase whose function is unknown. The N-terminal domain of the YchF protein belongs to the Obg-like family of GTPases, and some members of the...; Region: TGS_YchF_C; cd04867 114615015111 YdeM is a Bacillus subtilis protein that belongs to a family of prokaryotic proteins of unkown function. YdeM has sequence similarity to the hot-dog fold of (R)-specific enoyl-CoA hydratase. Other enzymes with this fold include the peroxisomal...; Region: YdeM; cd03454 114615015112 putative active site [active] 114615015113 putative catalytic site [active] 114615015114 YdeM is a Bacillus subtilis protein that belongs to a family of prokaryotic proteins of unkown function. YdeM has sequence similarity to the hot-dog fold of (R)-specific enoyl-CoA hydratase. Other enzymes with this fold include the peroxisomal...; Region: YdeM; cd03454 114615015115 putative active site [active] 114615015116 putative catalytic site [active] 114615015117 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109 114615015118 Sulfate transporter family; Region: Sulfate_transp; cl00967 114615015119 Uncharacterized protein involved in benzoate metabolism [Secondary metabolites biosynthesis, transport, and catabolism]; Region: BenE; COG3135 114615015120 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 114615015121 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 114615015122 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261 114615015123 dimer interface [polypeptide binding]; other site 114615015124 conserved gate region; other site 114615015125 putative PBP binding loops; other site 114615015126 ABC-ATPase subunit interface; other site 114615015127 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 114615015128 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261 114615015129 dimer interface [polypeptide binding]; other site 114615015130 conserved gate region; other site 114615015131 putative PBP binding loops; other site 114615015132 ABC-ATPase subunit interface; other site 114615015133 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 114615015134 GAF domain; Region: GAF; cl00853 114615015135 hypothetical protein; Provisional; Region: PRK13559 114615015136 Histidine kinase; Region: HisKA_2; cl06527 114615015137 Xanthine and CO dehydrogenases maturation factor, XdhC/CoxF family [Posttranslational modification, protein turnover, chaperones]; Region: XdhC; COG1975 114615015138 XdhC and CoxI family; Region: XdhC_CoxI; pfam02625 114615015139 Protein containing von Willebrand factor type A (vWA) domain [General function prediction only]; Region: CoxE; COG3552 114615015140 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198 114615015141 metal ion-dependent adhesion site (MIDAS); other site 114615015142 MoxR-like ATPases [General function prediction only]; Region: COG0714 114615015143 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes...; Region: AAA; cd00009 114615015144 Walker A motif; other site 114615015145 ATP binding site [chemical binding]; other site 114615015146 Walker B motif; other site 114615015147 carbon-monoxide dehydrogenase, large subunit; Region: CO_dehy_Mo_lg; TIGR02416 114615015148 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; cl03161 114615015149 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 114615015150 Aerobic-type carbon monoxide dehydrogenase, small subunit CoxS/CutS homologs [Energy production and conversion]; Region: CoxS; COG2080 114615015151 [2Fe-2S] binding domain; Region: Fer2_2; pfam01799 114615015152 Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM/CutM homologs [Energy production and conversion]; Region: CoxM; COG1319 114615015153 CO dehydrogenase flavoprotein C-terminal domain; Region: CO_deh_flav_C; cl08390 114615015154 MHYT domain (predicted integral membrane sensor domain) [Signal transduction mechanisms]; Region: COG3300 114615015155 Bacterial signalling protein N terminal repeat; Region: MHYT; pfam03707 114615015156 LytTr DNA-binding domain; Region: LytTR; cl04498 114615015157 lumazine synthase and riboflavin synthase; involved in the riboflavin (vitamin B2) biosynthetic pathway; Region: Lumazine_synthase-like; cl00317 114615015158 active site 114615015159 homopentamer interface [polypeptide binding]; other site 114615015160 Family of unknown function (DUF1790); Region: DUF1790; cl02283 114615015161 pyrroline-5-carboxylate reductase; Reviewed; Region: PRK11880 114615015162 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 114615015163 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 114615015164 4-Oxalocrotonate Tautomerase: Catalyzes the isomerization of unsaturated ketones. The structure is a homohexamer that is arranged as a trimer of dimers. The hexamer contains six active sites, each formed by residues from three monomers, two from one...; Region: 4Oxalocrotonate_Tautomerase; cl00235 114615015165 histidyl-tRNA synthetase; Region: hisS; TIGR00442 114615015166 Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: HisRS-like_core; cd00773 114615015167 dimer interface [polypeptide binding]; other site 114615015168 motif 1; other site 114615015169 motif 2; other site 114615015170 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 114615015171 active site 114615015172 motif 3; other site 114615015173 HisRS Histidyl-anticodon binding domain. HisRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: HisRS_anticodon; cd00859 114615015174 anticodon binding site; other site 114615015175 branched-chain amino acid aminotransferase; Provisional; Region: PRK13357 114615015176 BCAT_beta_family: Branched-chain aminotransferase catalyses the transamination of the branched-chain amino acids leusine, isoleucine and valine to their respective alpha-keto acids, alpha-ketoisocaproate, alpha-keto-beta-methylvalerate and alpha-...; Region: BCAT_beta_family; cd01557 114615015177 homodimer interface [polypeptide binding]; other site 114615015178 substrate-cofactor binding pocket; other site 114615015179 catalytic residue [active] 114615015180 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 114615015181 heavy metal response regulator; Region: cztR_silR_copR; TIGR01387 114615015182 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156 114615015183 active site 114615015184 phosphorylation site [posttranslational modification] 114615015185 intermolecular recognition site; other site 114615015186 dimerization interface [polypeptide binding]; other site 114615015187 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase...; Region: trans_reg_C; cd00383 114615015188 DNA binding site [nucleotide binding] 114615015189 Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices connected by an extended linker. The...; Region: HAMP; cl01054 114615015190 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via trans-...; Region: HisKA; cl00080 114615015191 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 114615015192 ATP binding site [chemical binding]; other site 114615015193 Mg2+ binding site [ion binding]; other site 114615015194 G-X-G motif; other site 114615015195 2,3-dihydroxybiphenyl 1,2-dioxygenase; Region: 23dbph12diox; TIGR03213 114615015196 N-terminal domain of 2,3-dihydroxybiphenyl 1,2-dioxygenase (BphC, EC 1.13.11.39) 1 from Rhodococcus globerulus P6 (BphC1-RGP6) and similar proteins; Region: BphC1-RGP6_N_like; cd07252 114615015197 C-terminal domain of 2,3-dihydroxybiphenyl 1,2-dioxygenase (BphC, EC 1.13.11.39) 1 from Rhodococcus globerulus P6 (BphC1-RGP6) and similar proteins; Region: BphC1-RGP6_C_like; cd07237 114615015198 active site 114615015199 Fe binding site [ion binding]; other site 114615015200 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 114615015201 Transcriptional regulator [Transcription]; Region: IclR; COG1414 114615015202 Bacterial transcriptional regulator; Region: IclR; pfam01614 114615015203 3-(3-hydroxyphenyl)propionate hydroxylase; Validated; Region: mhpA; PRK06183 114615015204 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 114615015205 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 114615015206 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; cl11421 114615015207 ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683 114615015208 Periplasmic solute-binding domain of active transport proteins that belong to the type I periplasmic binding fold protein family; Region: PBP1_SBP_like_1; cd06327 114615015209 putative ligand binding site [chemical binding]; other site 114615015210 Protein of unknown function (DUF3617); Region: DUF3617; pfam12276 114615015211 Ribonuclease T2 (RNase T2) is a widespread family of secreted RNases found in every organism examined thus far. This family includes RNase Rh, RNase MC1, RNase LE, and self-incompatibility RNases (S-RNases). Plant T2 RNases are expressed during leaf...; Region: RNase_T2_prok; cd01062 114615015212 B1 nucleotide binding pocket [chemical binding]; other site 114615015213 B2 nucleotide binding pocket [chemical binding]; other site 114615015214 CAS motifs; other site 114615015215 Active site [active] 114615015216 Protein involved in catabolism of external DNA [General function prediction only]; Region: ComJ; COG2961 114615015217 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box protein...; Region: CSP_CDS; cd04458 114615015218 DNA-binding site [nucleotide binding]; DNA binding site 114615015219 RNA-binding motif; other site 114615015220 Surface antigen; Region: Surface_Ag_2; cl01155 114615015221 excinuclease ABC subunit C; Validated; Region: uvrC; PRK00558 114615015222 Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434 114615015223 GIY-YIG motif/motif A; other site 114615015224 active site 114615015225 catalytic site [active] 114615015226 putative DNA binding site [nucleotide binding]; other site 114615015227 metal binding site [ion binding]; metal-binding site 114615015228 UvrB/uvrC motif; Region: UVR; pfam02151 114615015229 UvrC Helix-hairpin-helix N-terminal; Region: UvrC_HhH_N; pfam08459 114615015230 GIY-YIG domain of LuxR and ArsR family transcriptional regulators, and uncharacterized hypothetical proteins found in bacteria; Region: GIY-YIG_LuxR_like; cd10451 114615015231 GIY-YIG motif/motif A; other site 114615015232 CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; cl00453 114615015233 Ubiquitin domain of MoaD-like proteins; Region: MoaD; cd00754 114615015234 MoaE interaction surface [polypeptide binding]; other site 114615015235 MoeB interaction surface [polypeptide binding]; other site 114615015236 thiocarboxylated glycine; other site 114615015237 MoaE family. Members of this family are involved in biosynthesis of the molybdenum cofactor (Moco), an essential cofactor for a diverse group of redox enzymes. Moco biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoaE; cd00756 114615015238 MoaE homodimer interface [polypeptide binding]; other site 114615015239 MoaD interaction [polypeptide binding]; other site 114615015240 active site residues [active] 114615015241 N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase; Provisional; Region: PRK09328 114615015242 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cd02440 114615015243 S-adenosylmethionine binding site [chemical binding]; other site 114615015244 beta alanine--pyruvate transaminase; Provisional; Region: PRK09221 114615015245 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase...; Region: OAT_like; cd00610 114615015246 inhibitor-cofactor binding pocket; inhibition site 114615015247 pyridoxal 5'-phosphate binding site [chemical binding]; other site 114615015248 catalytic residue [active] 114615015249 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 114615015250 Predicted sugar phosphatases of the HAD superfamily [Carbohydrate transport and metabolism]; Region: NagD; COG0647 114615015251 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others...; Region: HAD_like; cd01427 114615015252 active site 114615015253 motif I; other site 114615015254 motif II; other site 114615015255 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others...; Region: HAD_like; cd01427 114615015256 Response regulator receiver domain; Region: Response_reg; pfam00072 114615015257 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156 114615015258 active site 114615015259 phosphorylation site [posttranslational modification] 114615015260 intermolecular recognition site; other site 114615015261 dimerization interface [polypeptide binding]; other site 114615015262 bifunctional riboflavin kinase/FMN adenylyltransferase; Reviewed; Region: PRK05627 114615015263 FAD synthetase, N-terminal domain of the bifunctional enzyme; Region: FAD_synthetase_N; cd02064 114615015264 active site 114615015265 Riboflavin kinase; Region: Flavokinase; cl03312 114615015266 isoleucyl-tRNA synthetase; Provisional; Region: ileS; PRK13804 114615015267 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 114615015268 active site 114615015269 HIGH motif; other site 114615015270 nucleotide binding site [chemical binding]; other site 114615015271 catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818 114615015272 active site 114615015273 KMSKS motif; other site 114615015274 Anticodon-binding domain of bacterial and eukaryotic mitochondrial isoleucyl tRNA synthetases; Region: Anticodon_Ia_Ile_BEm; cd07960 114615015275 tRNA binding surface [nucleotide binding]; other site 114615015276 anticodon binding site; other site 114615015277 Signal peptidase (SPase) II; Region: Peptidase_A8; cl00458 114615015278 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 114615015279 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 114615015280 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 114615015281 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 114615015282 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 114615015283 RF-1 domain; Region: RF-1; cl02875 114615015284 Cytochrome c; Region: Cytochrom_C; cl11414 114615015285 Glyoxalase I catalyzes the isomerization of the hemithioacetal, formed by a 2-oxoaldehyde and glutathione, to S-D-lactoylglutathione; Region: Glyoxalase_I; cd07233 114615015286 dimer interface [polypeptide binding]; other site 114615015287 active site 114615015288 metal binding site [ion binding]; metal-binding site 114615015289 glutathione binding site [chemical binding]; other site 114615015290 Choline dehydrogenase and related flavoproteins [Amino acid transport and metabolism]; Region: BetA; COG2303 114615015291 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 114615015292 Uncharacterized protein related to arylsulfate sulfotransferase involved in siderophore biosynthesis [General function prediction only]; Region: COG4321 114615015293 DNA mismatch repair protein; Reviewed; Region: mutL; PRK00095 114615015294 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075 114615015295 MutL_Trans: transducer domain, having a ribosomal S5 domain 2-like fold, conserved in the C-terminal domain of type II DNA topoisomerases (Topo II) and DNA mismatch repair (MutL/MLH1/PMS2) proteins. This transducer domain is homologous to the second...; Region: TopoII_MutL_Trans; cl02783 114615015296 ATP binding site [chemical binding]; other site 114615015297 MutL C terminal dimerisation domain; Region: MutL_C; cl07336 114615015298 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cd02440 114615015299 S-adenosylmethionine binding site [chemical binding]; other site 114615015300 transcription termination factor Rho; Provisional; Region: PRK12678 114615015301 16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187 114615015302 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 114615015303 RNA binding surface [nucleotide binding]; other site 114615015304 PseudoU_synth: Pseudouridine synthases catalyze the isomerization of specific uridines in an RNA molecule to pseudouridines (5-ribosyluracil, psi). Pseudouridine synthases contains the RsuA/RluD, TruA, TruB and TruD families. This group consists of...; Region: PseudoU_synth; cl00130 114615015305 active site 114615015306 Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285 114615015307 nucleoside/Zn binding site; other site 114615015308 dimer interface [polypeptide binding]; other site 114615015309 catalytic motif [active] 114615015310 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 114615015311 Cytochrome P450; Region: p450; cl12078 114615015312 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cl12011 114615015313 Double zinc ribbon; Region: DZR; pfam12773 114615015314 TOMM system kinase/cyclase multidomain protein; Region: TOMM_kin_cyc; TIGR03903 114615015315 cyclase homology domain; Region: CHD; cd07302 114615015316 nucleotidyl binding site; other site 114615015317 metal binding site [ion binding]; metal-binding site 114615015318 dimer interface [polypeptide binding]; other site 114615015319 phosphoribosylamine--glycine ligase; Provisional; Region: PRK00885 114615015320 Phosphoribosylglycinamide synthetase, N domain; Region: GARS_N; pfam02844 114615015321 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; cl03087 114615015322 Phosphoribosylglycinamide synthetase, C domain; Region: GARS_C; pfam02843 114615015323 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 114615015324 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 114615015325 exodeoxyribonuclease VII large subunit; Reviewed; Region: xseA; PRK00286 114615015326 ExoVII_LU_OBF: A subfamily of OB folds corresponding to the N-terminal OB-fold domain of Escherichia coli exodeoxyribonuclease VII (ExoVII) large subunit. E. coli ExoVII is composed of two non-identical subunits. E. coli ExoVII is a single-strand-...; Region: ExoVII_LU_OBF; cd04489 114615015327 generic binding surface II; other site 114615015328 generic binding surface I; other site 114615015329 Dienelactone hydrolase and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG0412 114615015330 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 114615015331 Uncharacterized protein conserved in bacteria (DUF2093); Region: DUF2093; cl11535 114615015332 Tetraacyldisaccharide-1-P 4'-kinase; Region: LpxK; cl03652 114615015333 3-deoxy-D-manno-octulosonic-acid transferase; Reviewed; Region: PRK05749 114615015334 3-Deoxy-D-manno-octulosonic-acid transferase (kdotransferase); Region: Glycos_transf_N; pfam04413 114615015335 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: DUF374; Region: LPLAT_DUF374-like; cd07983 114615015336 putative acyl-acceptor binding pocket; other site 114615015337 CysQ, a 3'-Phosphoadenosine-5'-phosphosulfate (PAPS) 3'-phosphatase, is a bacterial member of the inositol monophosphatase family. It has been proposed that CysQ helps control intracellular levels of PAPS, which is an intermediate in cysteine...; Region: CysQ; cd01638 114615015338 active site 114615015339 Putative modulator of DNA gyrase; Region: PmbA_TldD; pfam01523 114615015340 Predicted Zn-dependent proteases and their inactivated homologs [General function prediction only]; Region: TldD; cl00398 114615015341 UbiA prenyltransferase family; Region: UbiA; cl00337 114615015342 RNA methyltransferase; Region: Methyltrans_RNA; cl00611 114615015343 ATP phosphoribosyltransferase regulatory subunit; Provisional; Region: hisZ; PRK12295 114615015344 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 114615015345 motif 1; other site 114615015346 dimer interface [polypeptide binding]; other site 114615015347 active site 114615015348 motif 2; other site 114615015349 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 114615015350 active site 114615015351 motif 3; other site 114615015352 ATP phosphoribosyltransferase; Reviewed; Region: hisG; PRK00489 114615015353 ATP phosphoribosyltransferase; Region: HisG; cl15266 114615015354 undecaprenyl phosphate 4-deoxy-4-formamido-L-arabinose transferase; Provisional; Region: PRK10714 114615015355 Bacterial DPM1_like enzymes are related to eukaryotic DPM1; Region: DPM1_like_bac; cd04187 114615015356 Ligand binding site [chemical binding]; other site 114615015357 Putative Catalytic site [active] 114615015358 DXD motif; other site 114615015359 YdjC-like protein; Region: YdjC; cl01344 114615015360 Uncharacterized protein conserved in bacteria (DUF2076); Region: DUF2076; cl01353 114615015361 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 114615015362 Chemotaxis phosphatase, CheZ; Region: CheZ; cl01219 114615015363 Chaperonin 10 Kd subunit (cpn10 or GroES); Cpn10 cooperates with chaperonin 60 (cpn60 or GroEL), an ATPase, to assist the folding and assembly of proteins and is found in eubacterial cytosol, as well as in the matrix of mitochondria and chloroplasts...; Region: cpn10; cd00320 114615015364 oligomerisation interface [polypeptide binding]; other site 114615015365 mobile loop; other site 114615015366 roof hairpin; other site 114615015367 chaperonin GroEL; Reviewed; Region: groEL; PRK12852 114615015368 GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344 114615015369 ring oligomerisation interface [polypeptide binding]; other site 114615015370 ATP/Mg binding site [chemical binding]; other site 114615015371 stacking interactions; other site 114615015372 hinge regions; other site 114615015373 L-lactate permease; Region: Lactate_perm; cl00701 114615015374 glycolate transporter; Provisional; Region: PRK09695 114615015375 ABC-type uncharacterized transport system, permease and ATPase components [General function prediction only]; Region: COG4178 114615015376 ABC transporter transmembrane region; Region: ABC_membrane; cl00549 114615015377 Peroxisomal ATP-binding cassette transporter (Pat) is involved in the import of very long-chain fatty acids (VLCFA) into the peroxisome. The peroxisomal membrane forms a permeability barrier for a wide variety of metabolites required for and formed...; Region: ABCD_peroxisomal_ALDP; cd03223 114615015378 Bacterial protein of unknown function (Gcw_chp); Region: Gcw_chp; cl09901 114615015379 glycolate oxidase iron-sulfur subunit; Provisional; Region: glcF; PRK11274 114615015380 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved alpha-; Region: HCP_like; cl14655 114615015381 Cysteine-rich domain; Region: CCG; pfam02754 114615015382 Cysteine-rich domain; Region: CCG; pfam02754 114615015383 FAD binding domain; Region: FAD_binding_4; pfam01565 114615015384 glycolate oxidase FAD binding subunit; Provisional; Region: glcE; PRK11282 114615015385 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3514 114615015386 Protein of unknown function DUF262; Region: DUF262; cl14890 114615015387 Uncharacterized conserved protein (DUF2081); Region: DUF2081; cl09179 114615015388 Uncharacterized conserved protein (DUF2081); Region: DUF2081; cl09179 114615015389 glycolate oxidase subunit GlcD; Provisional; Region: PRK11230 114615015390 FAD binding domain; Region: FAD_binding_4; pfam01565 114615015391 Cytochrome c; Region: Cytochrom_C; cl11414 114615015392 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 114615015393 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi...; Region: TPR; cd00189 114615015394 binding surface 114615015395 TPR motif; other site 114615015396 Ribosomal protein L36; Region: Ribosomal_L36; cl00380 114615015397 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have...; Region: metallo-dependent_hydrolases; cl00281 114615015398 This CD, composed mainly of bacterial single-domain proteins, includes the Thermus thermophilus (Tt) YbaK-like protein, a homolog of the trans-acting Escherichia coli YbaK Cys-tRNA(Pro) deacylase and the Agrobacterium tumefaciens ProX Ala-tRNA(Pro)...; Region: ProX_deacylase; cd04333 114615015399 putative deacylase active site [active] 114615015400 LysR family transcriptional regulator; Provisional; Region: PRK14997 114615015401 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 114615015402 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 114615015403 putative effector binding pocket; other site 114615015404 dimerization interface [polypeptide binding]; other site 114615015405 Pirin-related protein [General function prediction only]; Region: COG1741 114615015406 Cupin domain; Region: Cupin_2; cl09118 114615015407 NADPH-dependent FMN reductase; Region: FMN_red; cl00438 114615015408 Domain of Unknown Function (DUF1080); Region: DUF1080; pfam06439 114615015409 PyridoxaL 5'-Phosphate Dependent Enzymes class IV (PLPDE_IV). This D-amino acid superfamily, one of five classes of PLPDE, consists of branched-chain amino acid aminotransferases (BCAT), D-amino acid transferases (DAAT), and 4-amino-4-deoxychorismate...; Region: PLPDE_IV; cl00224 114615015410 homodimer interface [polypeptide binding]; other site 114615015411 substrate-cofactor binding pocket; other site 114615015412 Aminotransferase class IV; Region: Aminotran_4; pfam01063 114615015413 pyridoxal 5'-phosphate binding site [chemical binding]; other site 114615015414 catalytic residue [active] 114615015415 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 114615015416 HisP and GlnQ are the ATP-binding components of the bacterial periplasmic histidine and glutamine permeases, repectively. Histidine permease is a multisubunit complex containing the HisQ and HisM integral membrane subunits and two copies of HisP; Region: ABC_HisP_GlnQ_permeases; cd03262 114615015417 Walker A/P-loop; other site 114615015418 ATP binding site [chemical binding]; other site 114615015419 Q-loop/lid; other site 114615015420 ABC transporter signature motif; other site 114615015421 Walker B; other site 114615015422 D-loop; other site 114615015423 H-loop/switch region; other site 114615015424 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261 114615015425 dimer interface [polypeptide binding]; other site 114615015426 conserved gate region; other site 114615015427 putative PBP binding loops; other site 114615015428 ABC-ATPase subunit interface; other site 114615015429 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 114615015430 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261 114615015431 dimer interface [polypeptide binding]; other site 114615015432 conserved gate region; other site 114615015433 putative PBP binding loops; other site 114615015434 ABC-ATPase subunit interface; other site 114615015435 glutamate and aspartate transporter subunit; Provisional; Region: PRK10797 114615015436 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and...; Region: PBPb; cd00134 114615015437 substrate binding pocket [chemical binding]; other site 114615015438 membrane-bound complex binding site; other site 114615015439 hinge residues; other site 114615015440 Uncharacterized M20 Dipeptidases; Region: M20_dipept_like_2; cd05679 114615015441 Acetylornithine deacetylase/Succinyl-diaminopimelate desuccinylase and related deacylases [Amino acid transport and metabolism]; Region: ArgE; COG0624 114615015442 metal binding site [ion binding]; metal-binding site 114615015443 putative dimer interface [polypeptide binding]; other site 114615015444 benzoylformate decarboxylase; Reviewed; Region: PRK07092 114615015445 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 114615015446 PYR/PP interface [polypeptide binding]; other site 114615015447 dimer interface [polypeptide binding]; other site 114615015448 TPP binding site [chemical binding]; other site 114615015449 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 114615015450 TPP-binding module; composed of proteins similar to Pseudomonas putida benzoylformate decarboxylase (BFDC). P. putida BFDC plays a role in the mandelate pathway, catalyzing the conversion of benzoylformate to benzaldehyde and carbon dioxide. This...; Region: TPP_BFDC; cd02002 114615015451 TPP-binding site [chemical binding]; other site 114615015452 dimer interface [polypeptide binding]; other site 114615015453 NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902 114615015454 Old yellow enzyme (OYE)-like FMN binding domain. OYE was the first flavin-dependent enzyme identified, however its true physiological role remains elusive to this day. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a...; Region: OYE_like_FMN; cd02933 114615015455 FMN binding site [chemical binding]; other site 114615015456 active site 114615015457 substrate binding site [chemical binding]; other site 114615015458 catalytic residue [active] 114615015459 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 114615015460 hypothetical protein; Provisional; Region: PRK06194 114615015461 classical (c) SDRs; Region: SDR_c; cd05233 114615015462 NAD(P) binding site [chemical binding]; other site 114615015463 active site 114615015464 yiaA/B two helix domain; Region: YiaAB; cl01759 114615015465 PspA/IM30 family; Region: PspA_IM30; pfam04012 114615015466 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 114615015467 ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683 114615015468 Type I periplasmic binding domain of uncharacterized extracellular ligand-binding proteins; Region: PBP1_STKc_like; cd06326 114615015469 putative ligand binding site [chemical binding]; other site 114615015470 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 114615015471 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 114615015472 Predicted O-acyltransferase [General function prediction only]; Region: COG3274; cl00792 114615015473 Acyltransferase family; Region: Acyl_transf_3; pfam01757 114615015474 phenylhydantoinase; Validated; Region: PRK08323 114615015475 D-hydantoinases (D-HYD) also called dihydropyrimidases (DHPase) and related proteins; DHPases are a family of enzymes that catalyze the reversible hydrolytic ring opening of the amide bond in five- or six-membered cyclic diamides, like...; Region: D-HYD; cd01314 114615015476 tetramer interface [polypeptide binding]; other site 114615015477 active site 114615015478 UDP-glucose 4-epimerase [Cell envelope biogenesis, outer membrane]; Region: GalE; COG1087 114615015479 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 114615015480 NAD(P) binding site [chemical binding]; other site 114615015481 active site 114615015482 Multidrug resistance efflux pump [Defense mechanisms]; Region: EmrA; COG1566 114615015483 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 114615015484 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 114615015485 putative substrate translocation pore; other site 114615015486 Phosphate-selective porin O and P; Region: Porin_O_P; cl01524 114615015487 Uncharacterized conserved protein [Function unknown]; Region: COG5476 114615015488 Protein of unknown function (DUF1485); Region: DUF1485; pfam07364 114615015489 MlrC C-terminus; Region: MlrC_C; pfam07171 114615015490 cyclase homology domain; Region: CHD; cd07302 114615015491 nucleotidyl binding site; other site 114615015492 metal binding site [ion binding]; metal-binding site 114615015493 dimer interface [polypeptide binding]; other site 114615015494 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 114615015495 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 114615015496 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 114615015497 AcrB/AcrD/AcrF family; Region: ACR_tran; pfam00873 114615015498 triphenylmethane reductase (TMR)-like proteins, NMRa-like, atypical (a) SDRs; Region: TMR_SDR_a; cd05269 114615015499 Predicted nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG0702 114615015500 NADP binding site [chemical binding]; other site 114615015501 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 114615015502 Spermidine/putrescine-binding periplasmic protein [Amino acid transport and metabolism]; Region: PotD; COG0687 114615015503 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 114615015504 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 114615015505 PotA is an ABC-type transporter and the ATPase component of the spermidine/putrescine-preferential uptake system consisting of PotA, -B, -C, and -D. PotA has two domains with the N-terminal domain containing the ATPase activity and the residues...; Region: ABC_PotA_N; cd03300 114615015506 Walker A/P-loop; other site 114615015507 ATP binding site [chemical binding]; other site 114615015508 Q-loop/lid; other site 114615015509 ABC transporter signature motif; other site 114615015510 Walker B; other site 114615015511 D-loop; other site 114615015512 H-loop/switch region; other site 114615015513 TOBE domain; Region: TOBE_2; cl01440 114615015514 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261 114615015515 dimer interface [polypeptide binding]; other site 114615015516 conserved gate region; other site 114615015517 putative PBP binding loops; other site 114615015518 ABC-ATPase subunit interface; other site 114615015519 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261 114615015520 dimer interface [polypeptide binding]; other site 114615015521 conserved gate region; other site 114615015522 putative PBP binding loops; other site 114615015523 ABC-ATPase subunit interface; other site 114615015524 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 114615015525 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 114615015526 NAD(P) binding site [chemical binding]; other site 114615015527 active site 114615015528 Beta-lactamase; Region: Beta-lactamase; cl01009 114615015529 Tripartite tricarboxylate transporter family receptor; Region: TctC; cl15260 114615015530 LysR family transcriptional regulator; Provisional; Region: PRK14997 114615015531 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 114615015532 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 114615015533 putative effector binding pocket; other site 114615015534 dimerization interface [polypeptide binding]; other site 114615015535 NADPH-dependent FMN reductase; Region: FMN_red; cl00438 114615015536 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084 114615015537 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 114615015538 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 114615015539 Coenzyme A binding pocket [chemical binding]; other site 114615015540 LanC-like proteins. LanC is the cyclase enzyme of the lanthionine synthetase. Lanthionine is a lantibiotic, a unique class of peptide antibiotics. They are ribosomally synthesized as a precursor peptide and then post-translationally modified to contain...; Region: LanC_like; cl04955 114615015541 active site 114615015542 zinc binding site [ion binding]; other site 114615015543 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 114615015544 Coenzyme A binding pocket [chemical binding]; other site 114615015545 Histone acetyltransferase [Transcription / Chromatin structure and dynamics]; Region: ELP3; COG1243 114615015546 Glycosyltransferase family 9 (heptosyltransferase); Region: Glyco_transf_9; pfam01075 114615015547 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 114615015548 hypothetical protein; Provisional; Region: PRK09945 114615015549 type I secretion membrane fusion protein, HlyD family; Region: type_I_hlyD; TIGR01843 114615015550 Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2...; Region: Biotinyl_lipoyl_domains; cl11404 114615015551 A sub-family of peptidase C39 which contains Cyclolysin and Hemolysin processing peptidases. Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the 'double-glycine'...; Region: Peptidase_C39_likeA; cd02417 114615015552 type I secretion system ABC transporter, HlyB family; Region: type_I_sec_HlyB; TIGR01846 114615015553 ABC transporter transmembrane region; Region: ABC_membrane; cl00549 114615015554 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 114615015555 Walker A/P-loop; other site 114615015556 ATP binding site [chemical binding]; other site 114615015557 Q-loop/lid; other site 114615015558 ABC transporter signature motif; other site 114615015559 Walker B; other site 114615015560 D-loop; other site 114615015561 H-loop/switch region; other site 114615015562 Transposase, Mutator family; Region: Transposase_mut; pfam00872 114615015563 Conjugal transfer protein TraD; Region: TraD; cl05753 114615015564 Conjugal transfer protein TraD; Region: TraD; cl05753 114615015565 conjugal transfer relaxase TraA; Provisional; Region: PRK13889 114615015566 MobA/MobL family; Region: MobA_MobL; pfam03389 114615015567 Helicase; Region: Herpes_Helicase; pfam02689 114615015568 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 114615015569 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 114615015570 Int/Topo IB signature motif; other site 114615015571 active site 114615015572 DNA binding site [nucleotide binding] 114615015573 Response regulator receiver domain; Region: Response_reg; pfam00072 114615015574 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156 114615015575 active site 114615015576 phosphorylation site [posttranslational modification] 114615015577 intermolecular recognition site; other site 114615015578 dimerization interface [polypeptide binding]; other site 114615015579 N-formylglutamate amidohydrolase; Region: FGase; cl01522 114615015580 Predominantly bacterial family of Mg++ dependend phosphatases, related to inositol monophosphatases. These enzymes may dephosphorylate fructose-1,6-bisphosphate, inositol monophospate, 3'-phosphoadenosine-5'-phosphate, or similar substrates; Region: Bacterial_IMPase_like_1; cd01641 114615015581 active site 114615015582 Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices connected by an extended linker. The...; Region: HAMP; cl01054 114615015583 Taxis toward Aspartate and Related amino acids and Homologs (TarH). The Tar chemoreceptor of Escherichia coli mediates attractant responses to aspartate, maltose, and phenol, repellent responses to Ni2+ and Co2+, and thermoresponses. These...; Region: TarH; cl00144 114615015584 Transcriptional regulator [Transcription]; Region: LysR; COG0583 114615015585 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 114615015586 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator, contains the type 2 periplasmic binding fold; Region: PBP2_LTTR_like_1; cd08421 114615015587 putative dimerization interface [polypeptide binding]; other site 114615015588 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 114615015589 LysE type translocator; Region: LysE; cl00565 114615015590 cyclase homology domain; Region: CHD; cd07302 114615015591 nucleotidyl binding site; other site 114615015592 metal binding site [ion binding]; metal-binding site 114615015593 dimer interface [polypeptide binding]; other site 114615015594 Curli production assembly/transport component CsgG; Region: CsgG; cl00639 114615015595 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi...; Region: TPR; cd00189 114615015596 TPR motif; other site 114615015597 binding surface 114615015598 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi...; Region: TPR; cd00189 114615015599 TPR motif; other site 114615015600 binding surface 114615015601 cyclase homology domain; Region: CHD; cd07302 114615015602 nucleotidyl binding site; other site 114615015603 metal binding site [ion binding]; metal-binding site 114615015604 dimer interface [polypeptide binding]; other site 114615015605 Curli production assembly/transport component CsgG; Region: CsgG; cl00639 114615015606 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi...; Region: TPR; cd00189 114615015607 TPR motif; other site 114615015608 binding surface 114615015609 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi...; Region: TPR; cd00189 114615015610 TPR motif; other site 114615015611 binding surface 114615015612 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3002 114615015613 Uncharacterized protein conserved in bacteria (DUF2309); Region: DUF2309; pfam10070 114615015614 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; cl14187 114615015615 transcriptional activator NhaR; Provisional; Region: nhaR; PRK11062 114615015616 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 114615015617 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 114615015618 dimerization interface [polypeptide binding]; other site 114615015619 hypothetical protein; Provisional; Region: PRK13559 114615015620 Histidine kinase; Region: HisKA_2; cl06527 114615015621 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cl12011 114615015622 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 114615015623 DNA-binding site [nucleotide binding]; DNA binding site 114615015624 FCD domain; Region: FCD; cl11656 114615015625 ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683 114615015626 Type I periplasmic ligand-binding domain of uncharacterized ABC (ATPase Binding Cassette)-type active transport systems that are predicted to be involved in uptake of amino acids, peptides, or inorganic ions; Region: PBP1_ABC_ligand_binding_like_8; cd06343 114615015627 putative ligand binding site [chemical binding]; other site 114615015628 Lysophospholipase [Lipid metabolism]; Region: PldB; COG2267 114615015629 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 114615015630 Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071 114615015631 Alpha-crystallin domain (ACD) found in Escherichia coli inclusion body-associated proteins IbpA and IbpB, and similar proteins. IbpA and IbpB are 16 kDa small heat shock proteins (sHsps). sHsps are molecular chaperones that suppress protein...; Region: ACD_IbpA-B_like; cd06470 114615015632 putative dimer interface [polypeptide binding]; other site 114615015633 glutamate synthase subunit alpha; Provisional; Region: gltB; PRK11750 114615015634 Glutamine amidotransferases class-II (Gn-AT), glutamate synthase (GltS)-type. GltS is a homodimer that synthesizes L-glutamate from 2-oxoglutarate and L-glutamine, an important step in ammonia assimilation in bacteria, cyanobacteria and plants. The N-...; Region: GltS; cd00713 114615015635 active site 114615015636 dimer interface [polypeptide binding]; other site 114615015637 Glutamate synthase central domain; Region: Glu_syn_central; pfam04898 114615015638 Glutamate synthase (GltS) FMN-binding domain. GltS is a complex iron-sulfur flavoprotein that catalyzes the reductive synthesis of L-glutamate from 2-oxoglutarate and L-glutamine via intramolecular channelling of ammonia, a reaction in the plant...; Region: GltS_FMN; cd02808 114615015639 active site 114615015640 FMN binding site [chemical binding]; other site 114615015641 substrate binding site [chemical binding]; other site 114615015642 3Fe-4S cluster binding site [ion binding]; other site 114615015643 gltb_C. This domain is found at the C-terminus of the large subunit (gltB) of glutamate synthase (GltS). GltS encodes a complex iron-sulfur flavoprotein that catalyzes the synthesis of L-glutamate from L-glutamine and 2-oxoglutarate. It requires the...; Region: gltB_C; cd00982 114615015644 domain interface; other site 114615015645 glutamate synthase subunit beta; Reviewed; Region: gltD; PRK12810 114615015646 N-acetyltransferase; Region: Acetyltransf_2; cl00949 114615015647 N-acetyltransferase; Region: Acetyltransf_2; cl00949 114615015648 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 114615015649 Uncharacterized conserved protein [Function unknown]; Region: COG2128 114615015650 Carboxymuconolactone decarboxylase family; Region: CMD; cl00460 114615015651 KpsF/GutQ family protein; Region: kpsF; TIGR00393 114615015652 KpsF-like protein. KpsF is an arabinose-5-phosphate isomerase which contains SIS (Sugar ISomerase) domains. SIS domains are found in many phosphosugar isomerases and phosphosugar binding proteins. KpsF catalyzes the reversible reaction of ribulose 5-...; Region: SIS_Kpsf; cd05014 114615015653 putative active site [active] 114615015654 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with KpsF/GutQ domains in the API [A5P (D-arabinose 5-phosphate) isomerase] protein. These APIs catalyze the conversion of the pentose pathway...; Region: CBS_pair_KpsF_GutQ_assoc; cd04604 114615015655 Uncharacterized protein conserved in bacteria (DUF2320); Region: DUF2320; cl12051 114615015656 NfeD-like C-terminal, partner-binding; Region: NfeD; cl00686 114615015657 Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330 114615015658 Band_7_stomatin_like: A subgroup of the band 7 domain of flotillin (reggie) like proteins similar to stomatin and podicin (two lipid raft-associated integral membrane proteins). Individual proteins of this band 7 domain family may cluster to form...; Region: Band_7_stomatin_like; cd03403 114615015659 ferrochelatase; Reviewed; Region: hemH; PRK00035 114615015660 Ferrochelatase, N-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_N; cd03411 114615015661 C-terminal domain interface [polypeptide binding]; other site 114615015662 active site 114615015663 Ferrochelatase, C-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_C; cd00419 114615015664 active site 114615015665 N-terminal domain interface [polypeptide binding]; other site 114615015666 MAPEG family; Region: MAPEG; cl09190 114615015667 Squalene cyclase (SQCY) domain subgroup 1; found in class II terpene cyclases that have an alpha 6 - alpha 6 barrel fold. Squalene cyclase (SQCY) and 2,3-oxidosqualene cyclase (OSQCY) are integral membrane proteins that catalyze a cationic cyclization...; Region: SQCY_1; cd02892 114615015668 squalene-hopene cyclase; Region: hopene_cyclase; TIGR01507 114615015669 Active site cavity [active] 114615015670 catalytic acid [active] 114615015671 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 114615015672 NAD(P) binding site [chemical binding]; other site 114615015673 active site 114615015674 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109 114615015675 Transcriptional regulator [Transcription]; Region: LysR; COG0583 114615015676 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 114615015677 The C-terminal substrate binding domain of LysR-type transcriptional regulators that involved in the catabolism of nitroaromatic/naphthalene compounds and that of related regulators; contains the type 2 periplasmic binding fold; Region: PBP2_Nitroaromatics_like; cd08417 114615015678 substrate binding pocket [chemical binding]; other site 114615015679 dimerization interface [polypeptide binding]; other site 114615015680 High-affinity nickel-transport protein; Region: NicO; cl00964 114615015681 High-affinity nickel-transport protein; Region: NicO; cl00964 114615015682 Protein of unknown function (DUF1007); Region: DUF1007; cl01487 114615015683 Zn-dependent oligopeptidases [Amino acid transport and metabolism]; Region: Dcp; COG0339 114615015684 Peptidase family M3 dipeptidyl carboxypeptidase (DCP); Region: M3A_DCP; cd06456 114615015685 active site 114615015686 Zn binding site [ion binding]; other site 114615015687 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Ornithine Decarboxylase; Region: PLPDE_III_ODC; cd00622 114615015688 dimer interface [polypeptide binding]; other site 114615015689 Diaminopimelate decarboxylase [Amino acid transport and metabolism]; Region: LysA; COG0019 114615015690 active site 114615015691 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 114615015692 catalytic residues [active] 114615015693 substrate binding site [chemical binding]; other site 114615015694 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 114615015695 This group of proteins belong to a large family of YjgF/YER057c/UK114-like proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence...; Region: YjgF_YER057c_UK114_like_6; cd06154 114615015696 homotrimer interaction site [polypeptide binding]; other site 114615015697 putative active site [active] 114615015698 Homospermidine synthase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG5310 114615015699 Saccharopine dehydrogenase; Region: Saccharop_dh; pfam03435 114615015700 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues...; Region: WD40; cl02567 114615015701 structural tetrad; other site 114615015702 Putative GTPases (G3E family) [General function prediction only]; Region: COG0523 114615015703 The function of this protein family is unkown. The amino acid sequence of YjiA protein in E. coli contains several conserved motifs that characterizes it as a P-loop GTPase. YijA gene is among the genes significantly induced in response to DNA-damage...; Region: CobW_like; cd03112 114615015704 P-loop, Walker A motif; other site 114615015705 Base recognition motif; other site 114615015706 Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; cl08458 114615015707 Metal binding protein PsaA. These proteins have been shown to function as initial receptors in ABC transport of Mn2+ and as surface adhesins in some eubacterial species. They belong to the TroA superfamily of periplasmic metal binding proteins that...; Region: PsaA; cd01137 114615015708 Periplasmic solute binding protein family; Region: SBP_bac_9; pfam01297 114615015709 metal binding site [ion binding]; metal-binding site 114615015710 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist...; Region: TM_ABC_iron-siderophores_like; cd06550 114615015711 ABC-ATPase subunit interface; other site 114615015712 dimer interface [polypeptide binding]; other site 114615015713 putative PBP binding regions; other site 114615015714 ABC-type Mn/Zn transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: ZnuC; COG1121 114615015715 ABC component of the metal-type transporters. This family includes transporters involved in the uptake of various metallic cations such as iron, manganese, and zinc. The ATPases of this group of transporters are very similar to members of iron-...; Region: ABC_Metallic_Cations; cd03235 114615015716 CrcB-like protein; Region: CRCB; cl09114 114615015717 Superoxide dismutase [Inorganic ion transport and metabolism]; Region: SodA; COG0605 114615015718 Iron/manganese superoxide dismutases, alpha-hairpin domain; Region: Sod_Fe_N; pfam00081 114615015719 Iron/manganese superoxide dismutases, C-terminal domain; Region: Sod_Fe_C; pfam02777 114615015720 Predicted acetyltransferase involved in intracellular survival and related acetyltransferases [General function prediction only]; Region: Eis; COG4552 114615015721 Uncharacterized protein conserved in bacteria (DUF2147); Region: DUF2147; cl01951 114615015722 Protein of unknown function (DUF3095); Region: DUF3095; pfam11294 114615015723 Uncharacterised ACR, YagE family COG1723; Region: DUF155; cl00751 114615015724 Uncharacterized membrane protein [Function unknown]; Region: SapB; COG1285 114615015725 MgtC family; Region: MgtC; cl12207 114615015726 Cytochrome c; Region: Cytochrom_C; cl11414 114615015727 Cytochrome c; Region: Cytochrom_C; cl11414 114615015728 Cytochrome c; Region: Cytochrom_C; cl11414 114615015729 Cytochrome c; Region: Cytochrom_C; cl11414 114615015730 Surface antigen; Region: Surface_Ag_2; cl01155 114615015731 Cytochrome c; Region: Cytochrom_C; cl11414 114615015732 Cytochrome c; Region: Cytochrom_C; cl11414 114615015733 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 114615015734 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 114615015735 ligand binding site [chemical binding]; other site 114615015736 flexible hinge region; other site 114615015737 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 114615015738 putative switch regulator; other site 114615015739 non-specific DNA interactions [nucleotide binding]; other site 114615015740 DNA binding site [nucleotide binding] 114615015741 sequence specific DNA binding site [nucleotide binding]; other site 114615015742 putative cAMP binding site [chemical binding]; other site 114615015743 heavy metal-(Cd/Co/Hg/Pb/Zn)-translocating P-type ATPase; Region: ATPase-IB2_Cd; TIGR01512 114615015744 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 114615015745 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 114615015746 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 114615015747 NAD(P) binding site [chemical binding]; other site 114615015748 active site 114615015749 Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318 114615015750 Acyl-protein synthetase, LuxE; Region: LuxE; cl10450 114615015751 long-chain-acyl-CoA synthetase; Validated; Region: PRK08279 114615015752 Acyl-protein synthetase, LuxE; Region: LuxE; cl10450 114615015753 Tripartite tricarboxylate transporter family receptor; Region: TctC; cl15260 114615015754 heat shock protein 90; Provisional; Region: PRK05218 114615015755 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 114615015756 ATP binding site [chemical binding]; other site 114615015757 Mg2+ binding site [ion binding]; other site 114615015758 G-X-G motif; other site 114615015759 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 114615015760 N-terminal domain of Sphingobium chlorophenolicum 2,6-dichloro-p-hydroquinone 1,2-dioxygenase (PcpA), and similar proteins; Region: PcpA_N_like; cd08346 114615015761 Zn binding site [ion binding]; other site 114615015762 FAD-dependent oxidoreductase; Provisional; Region: PRK08132 114615015763 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 114615015764 Protein of unknown function (DUF2783); Region: DUF2783; pfam10932 114615015765 Putative silver efflux pump [Inorganic ion transport and metabolism]; Region: COG3696 114615015766 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 114615015767 Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; cl00556 114615015768 Cytochrome b (N-terminus)/b6/petB: Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria...; Region: Cytochrome_b_N; cl00859 114615015769 Imelysin; Region: Peptidase_M75; cl09159 114615015770 Uncharacterized protein conserved in bacteria (DUF2320); Region: DUF2320; cl12051 114615015771 Periplasmic protein TonB, links inner and outer membranes [Cell envelope biogenesis, outer membrane]; Region: TonB; COG0810 114615015772 Gram-negative bacterial tonB protein; Region: TonB; cl10048 114615015773 Biopolymer transport protein ExbD/TolR; Region: ExbD; cl00537 114615015774 MotA/TolQ/ExbB proton channel family; Region: MotA_ExbB; cl00568 114615015775 Biopolymer transport proteins [Intracellular trafficking and secretion]; Region: TolQ; COG0811 114615015776 2OG-Fe(II) oxygenase superfamily; Region: 2OG-FeII_Oxy; cl01206 114615015777 catecholate siderophore receptor Fiu; Provisional; Region: PRK09840 114615015778 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 114615015779 N-terminal plug; other site 114615015780 ligand-binding site [chemical binding]; other site 114615015781 Outer membrane receptor for monomeric catechols [Inorganic ion transport and metabolism]; Region: Fiu; COG4774 114615015782 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 114615015783 N-terminal plug; other site 114615015784 ligand-binding site [chemical binding]; other site 114615015785 Amidohydrolase ring-opening protein (Amido_AtzD_TrzD); Region: Amido_AtzD_TrzD; pfam09663 114615015786 ring-opening amidohydrolases; Region: amido_AtzD_TrzD; TIGR02714 114615015787 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 114615015788 Domain of unknown function (DUF427); Region: DUF427; cl00998 114615015789 thiamine pyrophosphate protein; Provisional; Region: PRK08273 114615015790 Pyrimidine (PYR) binding domain of POX; Region: TPP_PYR_POX; cd07039 114615015791 PYR/PP interface [polypeptide binding]; other site 114615015792 tetramer interface [polypeptide binding]; other site 114615015793 dimer interface [polypeptide binding]; other site 114615015794 TPP binding site [chemical binding]; other site 114615015795 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 114615015796 Thiamine pyrophosphate (TPP) family, Pyruvate oxidase (POX) subfamily, TPP-binding module; composed of proteins similar to Lactobacillus plantarum POX, which plays a key role in controlling acetate production under aerobic conditions. POX...; Region: TPP_POX; cd02014 114615015797 TPP-binding site [chemical binding]; other site 114615015798 Mandelate racemase (MR)-like subfamily of the enolase superfamily, subgroup 3. Enzymes of this subgroup share three conserved carboxylate ligands for the essential divalent metal ion (usually Mg2+), two aspartates and a glutamate, and conserved...; Region: MR_like_3; cd03328 114615015799 L-alanine-DL-glutamate epimerase and related enzymes of enolase superfamily [Cell envelope biogenesis, outer membrane / General function prediction only]; Region: COG4948 114615015800 putative active site pocket [active] 114615015801 putative metal binding site [ion binding]; other site 114615015802 Choline dehydrogenase and related flavoproteins [Amino acid transport and metabolism]; Region: BetA; COG2303 114615015803 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 114615015804 Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490 114615015805 Jacalin-like lectin domains of putative endonucleases/exonucleases/phosphatases and related proteins; Region: Jacalin_EEP; cd09615 114615015806 putative sugar binding site [chemical binding]; other site 114615015807 Ricin-type beta-trefoil; Carbohydrate-binding domain formed from presumed gene triplication. The domain is found in a variety of molecules serving diverse functions such as enzymatic activity, inhibitory toxicity and signal transduction. Highly...; Region: RICIN; cd00161 114615015808 putative sugar binding sites [chemical binding]; other site 114615015809 Q-X-W motif; other site 114615015810 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cl12011 114615015811 conserved hypothetical protein; Region: TIGR02466 114615015812 HupE / UreJ protein; Region: HupE_UreJ; cl01011 114615015813 HupE / UreJ protein; Region: HupE_UreJ; cl01011 114615015814 General secretion pathway protein M; Region: GspM_II; pfam10741 114615015815 Fimbrial assembly protein (PilN); Region: PilN; pfam05137 114615015816 General secretion pathway protein K; Region: GspK; pfam03934 114615015817 general secretion pathway protein H; Region: typeII_sec_gspH; TIGR01708 114615015818 Prokaryotic N-terminal methylation motif; Region: N_methyl; cl06830 114615015819 general secretion pathway protein G; Region: typeII_sec_gspG; TIGR01710 114615015820 Bacterial type II secretion system protein G; Region: GSPII_G; pfam08334 114615015821 Type II secretory pathway, component PulF [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulF; COG1459 114615015822 Bacterial type II secretion system protein F domain; Region: GSPII_F; cl00906 114615015823 Bacterial type II secretion system protein F domain; Region: GSPII_F; cl00906 114615015824 general secretory pathway protein E; Region: type_II_gspE; TIGR02533 114615015825 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 114615015826 Walker A motif; other site 114615015827 ATP binding site [chemical binding]; other site 114615015828 Walker B motif; other site 114615015829 general secretion pathway protein D; Region: type_II_gspD; TIGR02517 114615015830 Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958 114615015831 Bacterial type II and III secretion system protein; Region: Secretin; cl02829 114615015832 Sel1 repeat; Region: Sel1; cl02723 114615015833 Sel1 repeat; Region: Sel1; cl02723 114615015834 Sulfatase; Region: Sulfatase; cl10460 114615015835 Pyruvate phosphate dikinase, PEP/pyruvate binding domain; Region: PPDK_N; pfam01326 114615015836 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; cl01586 114615015837 Uncharacterized FAD-dependent dehydrogenases [General function prediction only]; Region: COG2509 114615015838 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 114615015839 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 114615015840 Carbohydrate-selective porin [Cell envelope biogenesis, outer membrane]; Region: OprB; COG3659 114615015841 Carbohydrate-selective porin, OprB family; Region: OprB; pfam04966 114615015842 magnesium/nickel/cobalt transporter CorA; Provisional; Region: PRK11085; cl00459 114615015843 CorA-like Mg2+ transporter protein; Region: CorA; pfam01544 114615015844 Phosphate transporter family; Region: PHO4; cl00396 114615015845 Phosphate transporter family; Region: PHO4; cl00396 114615015846 bifunctional enoyl-CoA hydratase/phosphate acetyltransferase; Validated; Region: PRK08190 114615015847 (R)-hydratase [(R)-specific enoyl-CoA hydratase] catalyzes the hydration of trans-2-enoyl CoA to (R)-3-hydroxyacyl-CoA as part of the PHA (polyhydroxyalkanoate) biosynthetic pathway. (R)-hydratase contains a hot-dog fold similar to those of...; Region: R_hydratase; cd03449 114615015848 dimer interaction site [polypeptide binding]; other site 114615015849 substrate-binding tunnel; other site 114615015850 active site 114615015851 catalytic site [active] 114615015852 substrate binding site [chemical binding]; other site 114615015853 Phosphate acetyl/butaryl transferase; Region: PTA_PTB; cl00390 114615015854 Acetokinase family; Region: Acetate_kinase; cl01029 114615015855 PHB de-polymerase C-terminus; Region: PHB_depo_C; cl14907 114615015856 Enoyl-[acyl-carrier-protein]; Region: FabI; COG0623 114615015857 Enoyl acyl carrier protein (ACP) reductase (ENR), divergent SDR; Region: ENR_SDR; cd05372 114615015858 NAD binding site [chemical binding]; other site 114615015859 homotetramer interface [polypeptide binding]; other site 114615015860 homodimer interface [polypeptide binding]; other site 114615015861 substrate binding site [chemical binding]; other site 114615015862 active site 114615015863 Beta-lactamase; Region: Beta-lactamase; cl01009 114615015864 Predicted acyltransferases [Lipid metabolism]; Region: COG1835 114615015865 PAP2_like proteins, a super-family of histidine phosphatases and vanadium haloperoxidases, includes type 2 phosphatidic acid phosphatase or lipid phosphate phosphatase (LPP), Glucose-6-phosphatase, Phosphatidylglycerophosphatase B and bacterial acid...; Region: PAP2_like; cl00474 114615015866 active site 114615015867 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 114615015868 Type IV secretion-system coupling protein DNA-binding domain; Region: TrwB_AAD_bind; pfam10412 114615015869 Walker A motif; other site 114615015870 ATP binding site [chemical binding]; other site 114615015871 Walker B motif; other site 114615015872 Peptidase family M48; Region: Peptidase_M48; cl12018 114615015873 Replication protein; Region: Rep_1; cl02412 114615015874 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 114615015875 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 114615015876 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 114615015877 6-phosphofructo-2-kinase/fructose-2, 6-biphosphatase; Provisional; Region: PTZ00322 114615015878 Nitrilase superfamily, including nitrile- or amide-hydrolyzing enzymes and amide-condensing enzymes; Region: nitrilase; cd07197 114615015879 active site 114615015880 catalytic triad [active] 114615015881 dimer interface [polypeptide binding]; other site 114615015882 Antirestriction protein [DNA replication, recombination, and repair]; Region: COG4227 114615015883 Domain of unknown function (DUF1738); Region: DUF1738; pfam08401 114615015884 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl15258 114615015885 Domain of unknown function (DUF955); Region: DUF955; cl01076 114615015886 Predicted nucleotide-binding protein containing TIR-like domain; Region: TIR-like; cl01740 114615015887 Fic family protein [Function unknown]; Region: COG3177 114615015888 Fic/DOC family; Region: Fic; cl00960 114615015889 WGR domain of molybdate metabolism regulator and related proteins; Region: WGR_MMR_like; cd07996 114615015890 multiple promoter invertase; Provisional; Region: mpi; PRK13413 114615015891 Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and...; Region: SR_ResInv; cd03768 114615015892 catalytic residues [active] 114615015893 catalytic nucleophile [active] 114615015894 Presynaptic Site I dimer interface [polypeptide binding]; other site 114615015895 Synaptic Antiparallel dimer interface [polypeptide binding]; other site 114615015896 Synaptic Flat tetramer interface [polypeptide binding]; other site 114615015897 Synaptic Site I dimer interface [polypeptide binding]; other site 114615015898 DNA binding site [nucleotide binding] 114615015899 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cd00569 114615015900 DNA-binding interface [nucleotide binding]; DNA binding site 114615015901 Phage integrase, N-terminal; Region: Integrase_l_N; pfam12834 114615015902 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 114615015903 Int/Topo IB signature motif; other site 114615015904 active site 114615015905 DNA binding site [nucleotide binding] 114615015906 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 114615015907 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following...; Region: ParA; cd02042 114615015908 P-loop; other site 114615015909 Magnesium ion binding site [ion binding]; other site 114615015910 Replication initiator protein A; Region: RPA; cl02339 114615015911 Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and...; Region: SR_ResInv; cd03768 114615015912 catalytic residues [active] 114615015913 catalytic nucleophile [active] 114615015914 Presynaptic Site I dimer interface [polypeptide binding]; other site 114615015915 Synaptic Antiparallel dimer interface [polypeptide binding]; other site 114615015916 Synaptic Flat tetramer interface [polypeptide binding]; other site 114615015917 Synaptic Site I dimer interface [polypeptide binding]; other site 114615015918 DNA binding site [nucleotide binding] 114615015919 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cd00569 114615015920 DNA-binding interface [nucleotide binding]; DNA binding site 114615015921 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961 114615015922 Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cd00338 114615015923 catalytic residues [active] 114615015924 catalytic nucleophile [active] 114615015925 Recombinase; Region: Recombinase; pfam07508 114615015926 Coniferyl aldehyde dehydrogenase-like; Region: ALDH_CALDH_CalB; cd07133 114615015927 NAD(P) binding site [chemical binding]; other site 114615015928 catalytic residues [active] 114615015929 choline dehydrogenase; Validated; Region: PRK02106 114615015930 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 114615015931 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 114615015932 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 114615015933 NAD(P) binding site [chemical binding]; other site 114615015934 active site 114615015935 Colicin V production protein; Region: Colicin_V; cl00567 114615015936 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 114615015937 putative beta-ketoacyl acyl carrier protein [ACP] reductase (BKR)-like, SDR; Region: BKR_like_SDR_like; cd05344 114615015938 putative NAD(P) binding site [chemical binding]; other site 114615015939 putative active site [active] 114615015940 Protein of unknown function (DUF3775); Region: DUF3775; pfam12616 114615015941 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 114615015942 2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179 114615015943 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; cl11421 114615015944 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 114615015945 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 114615015946 C-terminal, alpha helical domain of an unknown subfamily 6 of Glutathione S-transferases; Region: GST_C_6; cd03205 114615015947 dimer interface [polypeptide binding]; other site 114615015948 N-terminal domain interface [polypeptide binding]; other site 114615015949 putative substrate binding pocket (H-site) [chemical binding]; other site 114615015950 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 114615015951 Methylated DNA-protein cysteine methyltransferase [DNA replication, recombination, and repair]; Region: Ada; COG0350 114615015952 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 114615015953 DNA binding site [nucleotide binding] 114615015954 active site 114615015955 hypothetical protein; Provisional; Region: PRK07338 114615015956 M20 Peptidase Glutamate carboxypeptidase, a periplasmic enzyme; Region: M20_CPDG2; cd03885 114615015957 metal binding site [ion binding]; metal-binding site 114615015958 dimer interface [polypeptide binding]; other site 114615015959 Phytanoyl-CoA dioxygenase (PhyH); Region: PhyH; cl02184 114615015960 Predicted homoserine dehydrogenase [Amino acid transport and metabolism]; Region: COG4091 114615015961 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl14614 114615015962 NAD(P) binding site [chemical binding]; other site 114615015963 SAF domain; Region: SAF; cl00555 114615015964 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cl01116 114615015965 putative Helix-turn-helix domain of transposase IS66; Region: HTH_Tnp_IS66; cl14891 114615015966 putative Helix-turn-helix domain of transposase IS66; Region: HTH_Tnp_IS66; cl14891 114615015967 Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050 114615015968 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 114615015969 Peptidase family M23; Region: Peptidase_M23; pfam01551 114615015970 ATP-dependent chaperone ClpB; Region: chaperone_ClpB; TIGR03346 114615015971 Clp amino terminal domain; Region: Clp_N; pfam02861 114615015972 Clp amino terminal domain; Region: Clp_N; pfam02861 114615015973 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes...; Region: AAA; cd00009 114615015974 Walker A motif; other site 114615015975 ATP binding site [chemical binding]; other site 114615015976 Walker B motif; other site 114615015977 arginine finger; other site 114615015978 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes...; Region: AAA; cd00009 114615015979 Walker A motif; other site 114615015980 ATP binding site [chemical binding]; other site 114615015981 Walker B motif; other site 114615015982 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; cl11083 114615015983 Uncharacterized Fe-S protein [General function prediction only]; Region: COG3217 114615015984 MOSC N-terminal beta barrel domain; Region: MOSC_N; pfam03476 114615015985 MOSC domain; Region: MOSC; pfam03473 114615015986 NlpC/P60 family; Region: NLPC_P60; cl11438 114615015987 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 114615015988 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 114615015989 transcriptional regulator; Provisional; Region: PRK10632 114615015990 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 114615015991 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_2; cd08471 114615015992 putative effector binding pocket; other site 114615015993 putative dimerization interface [polypeptide binding]; other site 114615015994 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 114615015995 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 114615015996 Uncharacterised protein family UPF0047; Region: UPF0047; cl00439 114615015997 hypothetical protein; Provisional; Region: PRK06849 114615015998 SAM-dependent methyltransferases [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: SmtA; COG0500 114615015999 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cd02440 114615016000 S-adenosylmethionine binding site [chemical binding]; other site 114615016001 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 114615016002 Homoserine acetyltransferase [Amino acid transport and metabolism]; Region: MET2; COG2021 114615016003 hypothetical protein; Provisional; Region: PRK06034 114615016004 Chorismate mutase type II; Region: CM_2; cl00693 114615016005 Histidinol-phosphate/aromatic aminotransferase and cobyric acid decarboxylase [Amino acid transport and metabolism]; Region: HisC; COG0079 114615016006 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 114615016007 pyridoxal 5'-phosphate binding site [chemical binding]; other site 114615016008 homodimer interface [polypeptide binding]; other site 114615016009 catalytic residue [active] 114615016010 cyclohexadienyl dehydrogenase; Validated; Region: PRK07502 114615016011 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 114615016012 Uncharacterized protein conserved in bacteria (DUF2125); Region: DUF2125; cl11537 114615016013 GGCT-like domains, also called AIG2-like family. Gamma-glutamyl cyclotransferase (GGCT) catalyzes the formation of pyroglutamic acid (5-oxoproline) from dipeptides containing gamma-glutamyl, and is a dimeric protein. In Homo sapiens, the protein is...; Region: GGCT_like; cd06661 114615016014 putative active site pocket [active] 114615016015 dimerization interface [polypeptide binding]; other site 114615016016 putative catalytic residue [active] 114615016017 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 114615016018 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 114615016019 putative acyl-acceptor binding pocket; other site 114615016020 YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259 114615016021 putative active site [active] 114615016022 Cell division protein [Cell division and chromosome partitioning]; Region: FtsX; COG2177 114615016023 Predicted ATPase involved in cell division [Cell division and chromosome partitioning]; Region: FtsE; COG2884 114615016024 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 114615016025 Walker A/P-loop; other site 114615016026 ATP binding site [chemical binding]; other site 114615016027 Q-loop/lid; other site 114615016028 ABC transporter signature motif; other site 114615016029 Walker B; other site 114615016030 D-loop; other site 114615016031 H-loop/switch region; other site 114615016032 Protein of unknown function (DUF3426); Region: DUF3426; pfam11906 114615016033 Response regulator receiver domain; Region: Response_reg; pfam00072 114615016034 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156 114615016035 active site 114615016036 phosphorylation site [posttranslational modification] 114615016037 intermolecular recognition site; other site 114615016038 dimerization interface [polypeptide binding]; other site 114615016039 transcription elongation factor regulatory protein; Validated; Region: PRK06342 114615016040 C-term; Region: GreA_GreB; pfam01272 114615016041 Escherichia coli YfcE and related proteins, metallophosphatase domain; Region: MPP_YfcE; cd00841 114615016042 active site 114615016043 metal binding site [ion binding]; metal-binding site 114615016044 homotetramer interface [polypeptide binding]; other site 114615016045 TIGR02302 family protein; Region: aProt_lowcomp 114615016046 TIGR02302 family protein; Region: aProt_lowcomp 114615016047 Plasmid stabilisation system protein; Region: Plasmid_stabil; cl11422 114615016048 Domain of unknown function (DUF1902); Region: DUF1902; pfam08972 114615016049 putative transposase OrfB; Reviewed; Region: PHA02517 114615016050 Integrase core domain; Region: rve; cl01316 114615016051 N-acetyl-gamma-glutamyl-phosphate reductase; Validated; Region: argC; PRK00436 114615016052 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 114615016053 Semialdehyde dehydrogenase, dimerisation domain; Region: Semialdhyde_dhC; pfam02774 114615016054 diaminopimelate decarboxylase; Region: lysA; TIGR01048 114615016055 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Diaminopimelate Decarboxylase; Region: PLPDE_III_DapDC; cd06828 114615016056 active site 114615016057 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 114615016058 substrate binding site [chemical binding]; other site 114615016059 catalytic residues [active] 114615016060 dimer interface [polypeptide binding]; other site 114615016061 argininosuccinate lyase; Provisional; Region: PRK00855 114615016062 Argininosuccinate lyase (argininosuccinase, ASAL); Region: Argininosuccinate_lyase; cd01359 114615016063 active sites [active] 114615016064 tetramer interface [polypeptide binding]; other site 114615016065 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing...; Region: TlpA_like_family; cd02966 114615016066 catalytic residues [active] 114615016067 3-hydroxybutyryl-CoA dehydrogenase; Validated; Region: PRK07530 114615016068 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 114615016069 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 114615016070 The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_alpha; cd01715 114615016071 Electron transfer flavoprotein FAD-binding domain; Region: ETF_alpha; pfam00766 114615016072 Electron transfer flavoprotein, beta subunit [Energy production and conversion]; Region: FixA; COG2086 114615016073 The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_beta; cd01714 114615016074 Ligand binding site [chemical binding]; other site 114615016075 Cobalamin adenosyltransferase; Region: Cob_adeno_trans; cl00920 114615016076 Hypoxia induced protein conserved region; Region: HIG_1_N; pfam04588 114615016077 Ribonuclease BN-like family; Region: Ribonuclease_BN; cl07918 114615016078 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via trans-...; Region: HisKA; cl00080 114615016079 proteobacterial dedicated sortase system histidine kinase; Region: marine_sort_HK; TIGR03785 114615016080 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 114615016081 ATP binding site [chemical binding]; other site 114615016082 Mg2+ binding site [ion binding]; other site 114615016083 G-X-G motif; other site 114615016084 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156 114615016085 active site 114615016086 phosphorylation site [posttranslational modification] 114615016087 intermolecular recognition site; other site 114615016088 dimerization interface [polypeptide binding]; other site 114615016089 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 114615016090 active site 114615016091 HIGH motif; other site 114615016092 nucleotide binding site [chemical binding]; other site 114615016093 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 114615016094 active site 114615016095 KMSKS motif; other site 114615016096 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 114615016097 endonuclease III; Region: ENDO3c; smart00478 114615016098 minor groove reading motif; other site 114615016099 helix-hairpin-helix signature motif; other site 114615016100 substrate binding pocket [chemical binding]; other site 114615016101 active site 114615016102 Protein of unknown function (DUF2855); Region: DUF2855; pfam11017 114615016103 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl14614 114615016104 Uncharacterized conserved protein [Function unknown]; Region: COG3391 114615016105 SdiA-regulated; Region: SdiA-regulated; cl06158 114615016106 NHL repeat; Region: NHL; pfam01436 114615016107 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins...; Region: HNHc; cd00085 114615016108 active site 114615016109 PQQ-dependent alcohol dehydrogenase system; Region: PQQ_ABC_ATP; TIGR03864 114615016110 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 114615016111 Walker A/P-loop; other site 114615016112 ATP binding site [chemical binding]; other site 114615016113 Q-loop/lid; other site 114615016114 ABC transporter signature motif; other site 114615016115 Walker B; other site 114615016116 D-loop; other site 114615016117 H-loop/switch region; other site 114615016118 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 114615016119 ABC-2 type transporter; Region: ABC2_membrane; cl11417 114615016120 Beta-carotene ketolase/oxygenase (CrtW, also known as CrtO), the carotenoid astaxanthin biosynthetic enzyme, initially catalyzes the addition of two keto groups to carbons C4 and C4' of beta-carotene. Carotenoids are important natural pigments produced...; Region: CrtW_beta-carotene-ketolase; cd03513 114615016121 putative di-iron ligands [ion binding]; other site 114615016122 Trans-Isoprenyl Diphosphate Synthases, head-to-head; Region: Trans_IPPS_HH; cd00683 114615016123 active site lid residues [active] 114615016124 substrate binding pocket [chemical binding]; other site 114615016125 catalytic residues [active] 114615016126 substrate-Mg2+ binding site; other site 114615016127 aspartate-rich region 1; other site 114615016128 aspartate-rich region 2; other site 114615016129 Phytoene dehydrogenase and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG1233 114615016130 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 114615016131 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 114615016132 lycopene cyclase family protein; Region: carotene-cycl; TIGR01790 114615016133 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 114615016134 substrate binding pocket [chemical binding]; other site 114615016135 chain length determination region; other site 114615016136 substrate-Mg2+ binding site; other site 114615016137 catalytic residues [active] 114615016138 aspartate-rich region 1; other site 114615016139 active site lid residues [active] 114615016140 aspartate-rich region 2; other site 114615016141 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 114615016142 metal binding site [ion binding]; metal-binding site 114615016143 active site 114615016144 I-site; other site 114615016145 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 114615016146 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 114615016147 active site 114615016148 ATP binding site [chemical binding]; other site 114615016149 hypothetical protein; Reviewed; Region: PRK09588 114615016150 Hedgehog/Intein domain, found in Hedgehog proteins as well as proteins which contain inteins and undergo protein splicing (e.g. DnaB, RIR1-2, GyrA and Pol). In protein splicing an intervening polypeptide sequence - the intein - is excised from a...; Region: Hint; cl12032 114615016151 RF-1 domain; Region: RF-1; cl02875 114615016152 putative chaperone; Provisional; Region: PRK11678 114615016153 DNA polymerase III subunits gamma and tau; Validated; Region: PRK07994 114615016154 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 114615016155 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 114615016156 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 114615016157 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase...; Region: trans_reg_C; cd00383 114615016158 DNA binding site [nucleotide binding] 114615016159 Curli production assembly/transport component CsgG; Region: CsgG; cl00639 114615016160 putative PEP-CTERM system TPR-repeat lipoprotein; Region: PEP_TPR_lipo; TIGR02917 114615016161 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi...; Region: TPR; cd00189 114615016162 TPR motif; other site 114615016163 Flp/Fap pilin component; Region: Flp_Fap; cl01585 114615016164 tyramine oxidase; Provisional; Region: tynA; PRK11504 114615016165 Copper amine oxidase, N2 domain; Region: Cu_amine_oxidN2; pfam02727 114615016166 Copper amine oxidase, N3 domain; Region: Cu_amine_oxidN3; pfam02728 114615016167 Copper amine oxidase, enzyme domain; Region: Cu_amine_oxid; pfam01179 114615016168 Beta-lactamase; Region: Beta-lactamase; cl01009 114615016169 transcriptional regulator EutR; Provisional; Region: PRK10130 114615016170 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK08276 114615016171 Acyl-protein synthetase, LuxE; Region: LuxE; cl10450 114615016172 Acyl-protein synthetase, LuxE; Region: LuxE; cl10450 114615016173 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 114615016174 FAD binding domain; Region: FAD_binding_4; pfam01565 114615016175 Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]; Region: DegQ; COG0265 114615016176 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind C-...; Region: PDZ_serine_protease; cd00987 114615016177 protein binding site [polypeptide binding]; other site 114615016178 Predicted esterase [General function prediction only]; Region: COG0400 114615016179 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase...; Region: crotonase-like; cl14780 114615016180 DsbA family, Com1-like subfamily; composed of proteins similar to Com1, a 27-kDa outer membrane-associated immunoreactive protein originally found in both acute and chronic disease strains of the pathogenic bacteria Coxiella burnetti. It contains a...; Region: DsbA_Com1_like; cd03023 114615016181 DSBA-like thioredoxin domain; Region: DSBA; pfam01323 114615016182 catalytic residues [active] 114615016183 membrane protein AbrB duplication; Region: Gneg_AbrB_dup; TIGR03082 114615016184 Putative ammonia monooxygenase; Region: AmoA; pfam05145 114615016185 membrane protein AbrB duplication; Region: Gneg_AbrB_dup; TIGR03082 114615016186 Disulfide bond formation protein DsbB; Region: DsbB; cl00649 114615016187 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 114615016188 putative substrate translocation pore; other site 114615016189 Major Facilitator Superfamily; Region: MFS_1; pfam07690 114615016190 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 114615016191 NAD synthetase; Reviewed; Region: nadE; PRK02628 114615016192 Glutamine aminotransferase (GAT, glutaminase) domain of glutamine-dependent NAD synthetases (class 7 and 8 nitrilases); Region: GAT_Gln-NAD-synth; cd07570 114615016193 multimer interface [polypeptide binding]; other site 114615016194 active site 114615016195 catalytic triad [active] 114615016196 protein interface 1 [polypeptide binding]; other site 114615016197 NAD+ synthase is a homodimer, which catalyzes the final step in de novo nicotinamide adenine dinucleotide (NAD+) biosynthesis, an amide transfer from either ammonia or glutamine to nicotinic acid adenine dinucleotide (NaAD). The conversion of NaAD to...; Region: NAD_synthase; cd00553 114615016198 homodimer interface [polypeptide binding]; other site 114615016199 NAD binding pocket [chemical binding]; other site 114615016200 ATP binding pocket [chemical binding]; other site 114615016201 Mg binding site [ion binding]; other site 114615016202 active-site loop [active] 114615016203 atypical (a) SDRs, subgroup 4; Region: SDR_a4; cd05266 114615016204 putative NAD(P) binding site [chemical binding]; other site 114615016205 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 114615016206 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 114615016207 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 114615016208 classical (c) SDRs; Region: SDR_c; cd05233 114615016209 NAD(P) binding site [chemical binding]; other site 114615016210 active site 114615016211 alpha-ketoglutarate decarboxylase; Reviewed; Region: kgd; PRK12270 114615016212 Dioxygenases related to 2-nitropropane dioxygenase [General function prediction only]; Region: COG2070 114615016213 2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin...; Region: NPD_like; cd04730 114615016214 FMN binding site [chemical binding]; other site 114615016215 substrate binding site [chemical binding]; other site 114615016216 putative catalytic residue [active] 114615016217 acyl-CoA synthetase; Validated; Region: PRK06188 114615016218 Acyl-protein synthetase, LuxE; Region: LuxE; cl10450 114615016219 This CD represents a family of iron-molybdenum cluster-binding proteins that includes NifB, NifX, and NifY, all of which are involved in the synthesis of an iron-molybdenum cofactor (FeMo-co) that binds the active site of the dinitrogenase enzyme; Region: NifX_NifB; cl00252 114615016220 Four helix bundle sensory module for signal transduction; Region: 4HB_MCP_2; pfam12729 114615016221 Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices connected by an extended linker. The...; Region: HAMP; cl01054 114615016222 Taxis toward Aspartate and Related amino acids and Homologs (TarH). The Tar chemoreceptor of Escherichia coli mediates attractant responses to aspartate, maltose, and phenol, repellent responses to Ni2+ and Co2+, and thermoresponses. These...; Region: TarH; cl00144 114615016223 Septum formation topological specificity factor MinE; Region: MinE; cl00538 114615016224 Bacterial cell division requires the formation of a septum at mid-cell. The site is determined by the min operon products MinC, MinD and MinE. MinC is a nonspecific inhibitor of the septum protein FtsZ. MinE is the supressor of MinC. MinD plays a...; Region: MinD; cd02036 114615016225 Switch I; other site 114615016226 Switch II; other site 114615016227 septum formation inhibitor; Reviewed; Region: minC; PRK05177 114615016228 Septum formation inhibitor MinC, C-terminal domain; Region: MinC_C; pfam03775 114615016229 Type I periplasmic binding domain of uncharacterized extracellular ligand-binding proteins; Region: PBP1_STKc_like; cd06326 114615016230 putative ligand binding site [chemical binding]; other site 114615016231 ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683 114615016232 Type I periplasmic binding domain of uncharacterized extracellular ligand-binding proteins; Region: PBP1_STKc_like; cd06326 114615016233 putative ligand binding site [chemical binding]; other site 114615016234 ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683 114615016235 Type I periplasmic binding domain of uncharacterized extracellular ligand-binding proteins; Region: PBP1_STKc_like; cd06326 114615016236 putative ligand binding site [chemical binding]; other site 114615016237 Dioxygenases related to 2-nitropropane dioxygenase [General function prediction only]; Region: COG2070 114615016238 2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin...; Region: NPD_like; cd04730 114615016239 FMN binding site [chemical binding]; other site 114615016240 substrate binding site [chemical binding]; other site 114615016241 putative catalytic residue [active] 114615016242 SNARE associated Golgi protein; Region: SNARE_assoc; cl00429 114615016243 MazG nucleotide pyrophosphohydrolase domain; Region: MazG; cl00345 114615016244 NMT1/THI5 like; Region: NMT1; pfam09084 114615016245 Tripartite tricarboxylate transporter family receptor; Region: TctC; cl15260 114615016246 cyclic beta-1,2-glucan ABC transporter; Provisional; Region: PRK13657 114615016247 ABC transporter transmembrane region; Region: ABC_membrane; cl00549 114615016248 MTABC3 (also known as ABCB6) is a mitochondrial ATP-binding cassette protein involved in iron homeostasis and one of four ABC transporters expressed in the mitochondrial inner membrane, the other three being MDL1(ABC7), MDL2, and ATM1. In fact, the...; Region: ABC_MTABC3_MDL1_MDL2; cd03249 114615016249 Walker A/P-loop; other site 114615016250 ATP binding site [chemical binding]; other site 114615016251 Q-loop/lid; other site 114615016252 ABC transporter signature motif; other site 114615016253 Walker B; other site 114615016254 D-loop; other site 114615016255 H-loop/switch region; other site 114615016256 Beta-lactamase; Region: Beta-lactamase; cl01009 114615016257 D-alanyl-D-alanine carboxypeptidase; Region: Peptidase_S11; pfam00768 114615016258 Long-chain-fatty-acid--CoA ligase; Validated; Region: PRK07059 114615016259 Acyl-protein synthetase, LuxE; Region: LuxE; cl10450 114615016260 Peroxiredoxin (PRX) family, PRX5-like subfamily; members are similar to the human protein, PRX5, a homodimeric TRX peroxidase, widely expressed in tissues and found cellularly in mitochondria, peroxisomes and the cytosol. The cellular location of PRX5...; Region: PRX5_like; cd03013 114615016261 catalytic triad [active] 114615016262 dimer interface [polypeptide binding]; other site 114615016263 RNase HI family found mainly in prokaryotes; Region: RNase_HI_prokaryote_like; cd09278 114615016264 RNA/DNA hybrid binding site [nucleotide binding]; other site 114615016265 active site 114615016266 Homoserine Kinase, type II. Homoserine kinase is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs), RIO kinases, actin-fragmin kinase (AFK), and...; Region: HomoserineK_II; cd05153 114615016267 Phosphotransferase enzyme family; Region: APH; pfam01636 114615016268 putative active site [active] 114615016269 putative substrate binding site [chemical binding]; other site 114615016270 ATP binding site [chemical binding]; other site 114615016271 LytB protein; Region: LYTB; cl00507 114615016272 (E)-4-hydroxy-3-methyl-but-2-enyl pyrophosphate reductase (IPP and DMAPP forming); Region: ispH_lytB; TIGR00216 114615016273 Protein of unknown function (DUF1013); Region: DUF1013; cl11533 114615016274 Surface antigen; Region: Surface_Ag_2; cl01155 114615016275 Domain of unknown function (DUF3448); Region: DUF3448; pfam11930 114615016276 propionyl-CoA synthetase; Provisional; Region: prpE; PRK10524 114615016277 Acyl-protein synthetase, LuxE; Region: LuxE; cl10450 114615016278 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi...; Region: TPR; cd00189 114615016279 binding surface 114615016280 TPR motif; other site 114615016281 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 114615016282 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 114615016283 NAD(P) binding site [chemical binding]; other site 114615016284 active site 114615016285 Domain of unknown function (DUF1850); Region: DUF1850; cl01950 114615016286 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl09110 114615016287 DctM-like transporters; Region: DctM; pfam06808 114615016288 Tripartite tricarboxylate transporter family receptor; Region: TctC; cl15260 114615016289 TRAP-type uncharacterized transport system, periplasmic component [General function prediction only]; Region: Imp; COG2358 114615016290 Coenzyme A pyrophosphatase (CoAse), a member of the Nudix hydrolase superfamily, functions to catalyze the elimination of oxidized inactive CoA, which can inhibit CoA-utilizing enzymes. The need of CoAses mainly arises under conditions of oxidative...; Region: CoAse; cd03426 114615016291 putative active site [active] 114615016292 putative CoA binding site [chemical binding]; other site 114615016293 nudix motif; other site 114615016294 metal binding site [ion binding]; metal-binding site 114615016295 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 114615016296 CoenzymeA binding site [chemical binding]; other site 114615016297 subunit interaction site [polypeptide binding]; other site 114615016298 PHB binding site; other site 114615016299 Predicted oxidoreductases (related to aryl-alcohol dehydrogenases) [Energy production and conversion]; Region: Tas; COG0667 114615016300 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and...; Region: Aldo_ket_red; cd06660 114615016301 active site 114615016302 catalytic tetrad [active] 114615016303 StaR_like; a well-conserved protein found in bacteria, plants, and animals. A family member from Streptomyces toyocaensis, StaR is part of a gene cluster involved in the biosynthesis of glycopeptide antibiotics (GPAs), specifically A47934. It has been...; Region: StaR_like; cd05804 114615016304 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084 114615016305 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 114615016306 Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006 114615016307 A family including aminopeptidase P, aminopeptidase M, and prolidase. Also known as metallopeptidase family M24. This family of enzymes is able to cleave amido-, imido- and amidino-containing bonds. Members exibit relatively narrow substrate...; Region: APP_MetAP; cd01066 114615016308 active site 114615016309 Transcriptional regulators [Transcription]; Region: PurR; COG1609 114615016310 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl15258 114615016311 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 114615016312 dimerization interface [polypeptide binding]; other site 114615016313 ligand binding site [chemical binding]; other site 114615016314 N-acyl-D-aspartate/D-glutamate deacylase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3653 114615016315 D-aminoacylases (N-acyl-D-Amino acid amidohydrolases) catalyze the hydrolysis of N-acyl-D-amino acids to produce the corresponding D-amino acids, which are used as intermediates in the synthesis of pesticides, bioactive peptides, and antibiotics; Region: D-aminoacylase; cd01297 114615016316 active site 114615016317 putative substrate binding pocket [chemical binding]; other site 114615016318 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have...; Region: metallo-dependent_hydrolases; cl00281 114615016319 formaldehyde dehydrogenase (FDH)-like; Region: FDH_like_ADH2; cd08286 114615016320 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 114615016321 catalytic Zn binding site [ion binding]; other site 114615016322 structural Zn binding site [ion binding]; other site 114615016323 NAD(P) binding site [chemical binding]; other site 114615016324 glycogen synthase; Provisional; Region: PRK14099 114615016325 This family is most closely related to the GT1 family of glycosyltransferases. Glycogen synthase catalyzes the formation and elongation of the alpha-1,4-glucose backbone using ADP-glucose, the second and key step of glycogen biosynthesis. This family...; Region: GT1_Glycogen_synthase_DULL1_like; cd03791 114615016326 ADP-binding pocket [chemical binding]; other site 114615016327 homodimer interface [polypeptide binding]; other site 114615016328 glucose-1-phosphate adenylyltransferase; Provisional; Region: glgC; PRK00725 114615016329 ADP-glucose pyrophosphorylase is involved in the biosynthesis of glycogen or starch; Region: ADP_Glucose_PP; cd02508 114615016330 ligand binding site [chemical binding]; other site 114615016331 oligomer interface [polypeptide binding]; other site 114615016332 Glucose-1-phosphate adenylyltransferase, C-terminal Left-handed parallel beta helix (LbH) domain: Glucose-1-phosphate adenylyltransferase is also known as ADP-glucose synthase or ADP-glucose pyrophosphorylase. It catalyzes the first committed and rate-...; Region: LbH_G1P_AT_C; cd04651 114615016333 dimer interface [polypeptide binding]; other site 114615016334 N-terminal domain interface [polypeptide binding]; other site 114615016335 sulfate 1 binding site; other site 114615016336 pfkB family carbohydrate kinase; Region: PfkB; pfam00294 114615016337 Fructokinases (FRKs) mainly from bacteria and plants are enzymes with high specificity for fructose, as are all FRKs, but they catalyzes the conversion of fructose to fructose-6-phosphate, which is an entry point into glycolysis via conversion into...; Region: bac_FRK; cd01167 114615016338 putative substrate binding site [chemical binding]; other site 114615016339 putative ATP binding site [chemical binding]; other site 114615016340 Yersinia Pseudotuberculosis carbohydrate kinase-like subgroup; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_YpCarbK_like; cd07782 114615016341 FGGY-family pentulose kinase; Region: 5C_CHO_kinase; TIGR01315 114615016342 N- and C-terminal domain interface [polypeptide binding]; other site 114615016343 putative active site [active] 114615016344 putative MgATP binding site [chemical binding]; other site 114615016345 catalytic site [active] 114615016346 metal binding site [ion binding]; metal-binding site 114615016347 carbohydrate binding site [chemical binding]; other site 114615016348 putative homodimer interface [polypeptide binding]; other site 114615016349 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 114615016350 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 114615016351 NAD(P) binding site [chemical binding]; other site 114615016352 active site 114615016353 glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650 114615016354 The N-terminal ATPase domain of the maltose transporter, MalK. ATP binding cassette (ABC) proteins function from bacteria to human, mediating the translocation of substances into and out of cells or organelles. ABC transporters contain two...; Region: ABC_MalK_N; cd03301 114615016355 Walker A/P-loop; other site 114615016356 ATP binding site [chemical binding]; other site 114615016357 Q-loop/lid; other site 114615016358 ABC transporter signature motif; other site 114615016359 Walker B; other site 114615016360 D-loop; other site 114615016361 H-loop/switch region; other site 114615016362 TOBE domain; Region: TOBE_2; cl01440 114615016363 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cl00427 114615016364 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 114615016365 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261 114615016366 dimer interface [polypeptide binding]; other site 114615016367 conserved gate region; other site 114615016368 putative PBP binding loops; other site 114615016369 ABC-ATPase subunit interface; other site 114615016370 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 114615016371 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 114615016372 Transcriptional regulator, contains sigma factor-related N-terminal domain [Transcription]; Region: DeoR; COG2390 114615016373 Putative sugar-binding domain; Region: Sugar-bind; pfam04198 114615016374 Flagellar basal body rod protein [Cell motility and secretion]; Region: FlgC; COG1558 114615016375 Domain of unknown function (DUF1078); Region: DUF1078; pfam06429 114615016376 Isoprenylcysteine carboxyl methyltransferase (ICMT) family; Region: ICMT; cl00763 114615016377 bifunctional 3-demethylubiquinone-9 3-methyltransferase/ 2-octaprenyl-6-hydroxy phenol methylase; Provisional; Region: PRK05134 114615016378 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cd02440 114615016379 S-adenosylmethionine binding site [chemical binding]; other site 114615016380 Bacterial SH3 domain; Region: SH3_3; cl02551 114615016381 Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices connected by an extended linker. The...; Region: HAMP; cl01054 114615016382 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 114615016383 Taxis toward Aspartate and Related amino acids and Homologs (TarH). The Tar chemoreceptor of Escherichia coli mediates attractant responses to aspartate, maltose, and phenol, repellent responses to Ni2+ and Co2+, and thermoresponses. These...; Region: TarH; cl00144 114615016384 Domain of unknown function (DUF329); Region: DUF329; cl01144 114615016385 Maf-like protein; Region: Maf; pfam02545 114615016386 Nucleotide binding protein Maf. Maf has been implicated in inhibition of septum formation in eukaryotes, bacteria and archaea, but homologs in B.subtilis and S.cerevisiae are nonessential for cell division. Maf has been predicted to be a nucleotide- or...; Region: Maf; cd00555 114615016387 active site 114615016388 dimer interface [polypeptide binding]; other site 114615016389 Low molecular weight phosphatase family; Region: LMWPc; cd00115 114615016390 Active site [active] 114615016391 Uncharacterised protein family (UPF0262); Region: UPF0262; cl11489 114615016392 E.C 1.1.1.23. Histidinol dehydrogenase catalyzes the last two steps in the L-histidine biosynthesis pathway, which is conserved in bacteria, archaea, fungi, and plants. These last two steps are (i) the NAD-dependent oxidation of L-histidinol to L-...; Region: Histidinol_dh; cd06572 114615016393 NAD binding site [chemical binding]; other site 114615016394 dimerization interface [polypeptide binding]; other site 114615016395 product binding site; other site 114615016396 substrate binding site [chemical binding]; other site 114615016397 zinc binding site [ion binding]; other site 114615016398 catalytic residues [active] 114615016399 Protein of unknown function (DUF2948); Region: DUF2948; pfam11164 114615016400 UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Validated; Region: PRK09369 114615016401 UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555 114615016402 hinge; other site 114615016403 active site 114615016404 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 114615016405 ligand binding site [chemical binding]; other site 114615016406 flexible hinge region; other site 114615016407 thioredoxin-disulfide reductase; Region: TRX_reduct; TIGR01292 114615016408 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 114615016409 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 114615016410 pyruvate dehydrogenase; Provisional; Region: PRK09124 114615016411 Pyrimidine (PYR) binding domain of POX; Region: TPP_PYR_POX; cd07039 114615016412 PYR/PP interface [polypeptide binding]; other site 114615016413 tetramer interface [polypeptide binding]; other site 114615016414 dimer interface [polypeptide binding]; other site 114615016415 TPP binding site [chemical binding]; other site 114615016416 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 114615016417 Thiamine pyrophosphate (TPP) family, Pyruvate oxidase (POX) subfamily, TPP-binding module; composed of proteins similar to Lactobacillus plantarum POX, which plays a key role in controlling acetate production under aerobic conditions. POX...; Region: TPP_POX; cd02014 114615016418 TPP-binding site [chemical binding]; other site 114615016419 Predicted P-loop ATPase [General function prediction only]; Region: COG4928 114615016420 KAP family P-loop domain; Region: KAP_NTPase; pfam07693 114615016421 Carboxymuconolactone decarboxylase family; Region: CMD; cl00460 114615016422 Uncharacterized conserved protein [Function unknown]; Region: COG2128 114615016423 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK05565 114615016424 classical (c) SDRs; Region: SDR_c; cd05233 114615016425 NAD(P) binding site [chemical binding]; other site 114615016426 active site 114615016427 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_7; cd08512 114615016428 Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496 114615016429 Mg2+ and Co2+ transporters [Inorganic ion transport and metabolism]; Region: CorA; COG0598 114615016430 magnesium/nickel/cobalt transporter CorA; Provisional; Region: PRK11085; cl00459 114615016431 histidine kinase; Provisional; Region: PRK13557 114615016432 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 114615016433 putative active site [active] 114615016434 heme pocket [chemical binding]; other site 114615016435 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via trans-...; Region: HisKA; cd00082 114615016436 dimer interface [polypeptide binding]; other site 114615016437 phosphorylation site [posttranslational modification] 114615016438 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 114615016439 ATP binding site [chemical binding]; other site 114615016440 Mg2+ binding site [ion binding]; other site 114615016441 G-X-G motif; other site 114615016442 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156 114615016443 active site 114615016444 phosphorylation site [posttranslational modification] 114615016445 intermolecular recognition site; other site 114615016446 dimerization interface [polypeptide binding]; other site 114615016447 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 114615016448 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 114615016449 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 114615016450 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 114615016451 dimerization interface [polypeptide binding]; other site 114615016452 putative beta-ketoacyl acyl carrier protein [ACP] reductase (BKR)-like, SDR; Region: BKR_like_SDR_like; cd05344 114615016453 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK05565 114615016454 putative NAD(P) binding site [chemical binding]; other site 114615016455 putative active site [active] 114615016456 Glutamine synthetase [Amino acid transport and metabolism]; Region: GlnA; COG0174 114615016457 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 114615016458 Rieske non-heme iron oxygenase (RO) family, Phthalate 4,5-dioxygenase (PhDO)-like subfamily, N-terminal Rieske domain of the oxygenase alpha subunit; composed of the oxygenase alpha subunits of PhDO and similar proteins including 3-chlorobenzoate 3,4-...; Region: Rieske_RO_Alpha_PhDO_like; cd03479 114615016459 C-terminal catalytic domain of the oxygenase alpha subunit of dicamba O-demethylase and related aromatic ring hydroxylating dioxygenases; Region: RHO_alpha_C_DMO-like; cd08878 114615016460 alpha subunit interface [polypeptide binding]; other site 114615016461 active site 114615016462 substrate binding site [chemical binding]; other site 114615016463 Fe binding site [ion binding]; other site 114615016464 beta-ketoadipate pathway transcriptional regulators, PcaR/PcaU/PobR family; Region: pcaR_pcaU; TIGR02431 114615016465 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 114615016466 Bacterial transcriptional regulator; Region: IclR; pfam01614 114615016467 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 114615016468 DNA-binding transcriptional regulator EnvR; Provisional; Region: PRK09975 114615016469 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 114615016470 Aerobic-type carbon monoxide dehydrogenase, small subunit CoxS/CutS homologs [Energy production and conversion]; Region: CoxS; COG2080 114615016471 [2Fe-2S] binding domain; Region: Fer2_2; pfam01799 114615016472 Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM/CutM homologs [Energy production and conversion]; Region: CoxM; COG1319 114615016473 CO dehydrogenase flavoprotein C-terminal domain; Region: CO_deh_flav_C; cl08390 114615016474 Aerobic-type carbon monoxide dehydrogenase, large subunit CoxL/CutL homologs [Energy production and conversion]; Region: CoxL; COG1529 114615016475 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; cl03161 114615016476 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 114615016477 Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840 114615016478 Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices connected by an extended linker. The...; Region: HAMP; cl01054 114615016479 Taxis toward Aspartate and Related amino acids and Homologs (TarH). The Tar chemoreceptor of Escherichia coli mediates attractant responses to aspartate, maltose, and phenol, repellent responses to Ni2+ and Co2+, and thermoresponses. These...; Region: TarH; cl00144 114615016480 PilZ domain; Region: PilZ; cl01260 114615016481 TMAO reductase sytem sensor TorS; Region: TMAO_torS; TIGR02956 114615016482 Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices connected by an extended linker. The...; Region: HAMP; cl01054 114615016483 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 114615016484 Taxis toward Aspartate and Related amino acids and Homologs (TarH). The Tar chemoreceptor of Escherichia coli mediates attractant responses to aspartate, maltose, and phenol, repellent responses to Ni2+ and Co2+, and thermoresponses. These...; Region: TarH; cl00144 114615016485 Surface antigen; Region: Surface_Ag_2; cl01155 114615016486 TMAO reductase sytem sensor TorS; Region: TMAO_torS; TIGR02956 114615016487 Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices connected by an extended linker. The...; Region: HAMP; cl01054 114615016488 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 114615016489 Taxis toward Aspartate and Related amino acids and Homologs (TarH). The Tar chemoreceptor of Escherichia coli mediates attractant responses to aspartate, maltose, and phenol, repellent responses to Ni2+ and Co2+, and thermoresponses. These...; Region: TarH; cl00144 114615016490 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 114615016491 7-keto-8-aminopelargonate synthetase and related enzymes [Coenzyme metabolism]; Region: BioF; COG0156 114615016492 KBL_like; this family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to serine palmitoyltransferase (SPT), 5-aminolevulinate synthase (ALAS), 8-amino-7-...; Region: KBL_like; cd06454 114615016493 substrate-cofactor binding pocket; other site 114615016494 pyridoxal 5'-phosphate binding site [chemical binding]; other site 114615016495 catalytic residue [active] 114615016496 Sodium:solute symporter family; Region: SSF; cl00456 114615016497 PAS fold; Region: PAS_7; pfam12860 114615016498 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via trans-...; Region: HisKA; cl00080 114615016499 Signal transduction histidine kinase, glucose-6-phosphate specific [Signal transduction mechanisms]; Region: UhpB; COG3851 114615016500 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 114615016501 ATP binding site [chemical binding]; other site 114615016502 Mg2+ binding site [ion binding]; other site 114615016503 G-X-G motif; other site 114615016504 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 114615016505 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156 114615016506 active site 114615016507 phosphorylation site [posttranslational modification] 114615016508 intermolecular recognition site; other site 114615016509 dimerization interface [polypeptide binding]; other site 114615016510 Cupin domain; Region: Cupin_2; cl09118 114615016511 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 114615016512 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 114615016513 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 114615016514 Carboxymuconolactone decarboxylase family; Region: CMD; cl00460 114615016515 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 114615016516 LysR family transcriptional regulator; Provisional; Region: PRK14997 114615016517 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 114615016518 dimerization interface [polypeptide binding]; other site 114615016519 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 114615016520 Domain of Unknown Function with PDB structure; Region: DUF3857; pfam12969 114615016521 Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305 114615016522 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 114615016523 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156 114615016524 active site 114615016525 phosphorylation site [posttranslational modification] 114615016526 intermolecular recognition site; other site 114615016527 dimerization interface [polypeptide binding]; other site 114615016528 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors...; Region: LuxR_C_like; cd06170 114615016529 DNA binding residues [nucleotide binding] 114615016530 dimerization interface [polypeptide binding]; other site 114615016531 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 114615016532 putative substrate translocation pore; other site 114615016533 metabolite-proton symporter; Region: 2A0106; TIGR00883 114615016534 Uncharacterised protein family UPF0047; Region: UPF0047; cl00439 114615016535 2-hydroxychromene-2-carboxylate isomerase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: NahD; COG3917 114615016536 DsbA family, 2-hydroxychromene-2-carboxylate (HCCA) isomerase subfamily; HCCA isomerase is a glutathione (GSH) dependent enzyme involved in the naphthalene catabolic pathway. It converts HCCA, a hemiketal formed spontaneously after ring cleavage of 1,2-; Region: DsbA_HCCA_Iso; cd03022 114615016537 putative catalytic residue [active] 114615016538 Putative F0F1-ATPase subunit (ATPase_gene1); Region: ATPase_gene1; cl09754 114615016539 ATP synthase A chain; Region: ATP-synt_A; cl00413 114615016540 ATP synthase subunit C; Region: ATP-synt_C; cl00466 114615016541 ATP synthase B/B' CF(0); Region: ATP-synt_B; cl07975 114615016542 F0F1-type ATP synthase, subunit b [Energy production and conversion]; Region: AtpF; COG0711 114615016543 ATP synthase B/B' CF(0); Region: ATP-synt_B; cl07975 114615016544 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 114615016545 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 114615016546 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 114615016547 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 114615016548 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 114615016549 Threonine synthase [Amino acid transport and metabolism]; Region: ThrC; COG0498 114615016550 Threonine synthase catalyzes the final step of threonine biosynthesis. The conversion of O-phosphohomoserine into threonine and inorganic phosphate is pyridoxal 5'-phosphate dependent. The Thr-synth_1 CD includes members from higher plants...; Region: Thr-synth_2; cd01560 114615016551 pyridoxal 5'-phosphate binding site [chemical binding]; other site 114615016552 catalytic residue [active] 114615016553 Domain of unknown function (DUF74); Region: DUF74; cl00426 114615016554 Carboxymuconolactone decarboxylase family; Region: CMD; cl00460 114615016555 Helix-Turn-Helix DNA binding domain of the MerR-like transcription regulators YyaN and YraB; Region: HTH_YyaN; cd01109 114615016556 DNA binding residues [nucleotide binding] 114615016557 putative dimer interface [polypeptide binding]; other site 114615016558 SURF1 superfamily. Surf1/Shy1 has been implicated in the posttranslational steps of the biogenesis of the mitochondrially-encoded Cox1 subunit of cytochrome c oxidase (complex IV). Cytochrome c oxidase (complex IV), the terminal electron-transferring...; Region: SURF1; cd06662 114615016559 Protein of unknown function (DUF983); Region: DUF983; cl02211 114615016560 Cytochrome c oxidase subunit III. Cytochrome c oxidase (CcO), the terminal oxidase in the respiratory chains of eukaryotes and most bacteria, is a multi-chain transmembrane protein located in the inner membrane of mitochondria and the cell membrane of...; Region: Cyt_c_Oxidase_III; cd01665 114615016561 Subunit III/VIIa interface [polypeptide binding]; other site 114615016562 Phospholipid binding site [chemical binding]; other site 114615016563 Subunit I/III interface [polypeptide binding]; other site 114615016564 Subunit III/VIb interface [polypeptide binding]; other site 114615016565 Subunit III/VIa interface; other site 114615016566 Subunit III/Vb interface [polypeptide binding]; other site 114615016567 Cytochrome c oxidase assembly protein CtaG/Cox11; Region: CtaG_Cox11; cl01240 114615016568 UbiA prenyltransferase family; Region: UbiA; cl00337 114615016569 Heme/copper-type cytochrome/quinol oxidases, subunit 1 [Energy production and conversion]; Region: CyoB; COG0843 114615016570 Cytochrome C oxidase subunit I. Cytochrome c oxidase (CcO), the terminal oxidase in the respiratory chains of eukaryotes and most bacteria, is a multi-chain transmembrane protein located in the inner membrane of mitochondria and the cell membrane of...; Region: Cyt_c_Oxidase_I; cd01663 114615016571 Subunit I/III interface [polypeptide binding]; other site 114615016572 D-pathway; other site 114615016573 Subunit I/VIIc interface [polypeptide binding]; other site 114615016574 Subunit I/IV interface [polypeptide binding]; other site 114615016575 Subunit I/II interface [polypeptide binding]; other site 114615016576 Low-spin heme (heme a) binding site [chemical binding]; other site 114615016577 Subunit I/VIIa interface [polypeptide binding]; other site 114615016578 Subunit I/VIa interface [polypeptide binding]; other site 114615016579 Dimer interface; other site 114615016580 Putative water exit pathway; other site 114615016581 Binuclear center (heme a3/CuB) [ion binding]; other site 114615016582 K-pathway; other site 114615016583 Subunit I/Vb interface [polypeptide binding]; other site 114615016584 Putative proton exit pathway; other site 114615016585 Subunit I/VIb interface; other site 114615016586 Subunit I/VIc interface [polypeptide binding]; other site 114615016587 Electron transfer pathway; other site 114615016588 Subunit I/VIIIb interface [polypeptide binding]; other site 114615016589 Subunit I/VIIb interface [polypeptide binding]; other site 114615016590 Cytochrome C oxidase subunit II, transmembrane domain; Region: COX2_TM; pfam02790 114615016591 cytochrome c oxidase subunit II; Provisional; Region: COX2; MTH00154 114615016592 Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; cl11412 114615016593 Invasion associated locus B (IalB) protein; Region: IalB; cl02207 114615016594 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 114615016595 Predicted Zn-dependent proteases and their inactivated homologs [General function prediction only]; Region: TldD; cl00398 114615016596 Putative modulator of DNA gyrase; Region: PmbA_TldD; pfam01523 114615016597 signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227 114615016598 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 114615016599 Catalytic site [active] 114615016600 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 114615016601 Bacterial protein of unknown function (DUF925); Region: DUF925; cl01435 114615016602 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 114615016603 catalytic residues [active] 114615016604 PAN/APPLE-like domain; present in N-terminal (N) domains of plasminogen/ hepatocyte growth factor proteins, plasma prekallikrein/coagulation factor XI and microneme antigen proteins, plant receptor-like protein kinases, and various nematode and leech...; Region: PAN_APPLE; cl00112 114615016605 putative binding site; other site 114615016606 Glutamate-cysteine ligase family 2(GCS2); Region: GCS2; cl00954 114615016607 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 114615016608 glutathionine S-transferase; Provisional; Region: PRK10542 114615016609 GST_N family, Class Beta subfamily; GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of endogenous and xenobiotic alkylating agents, including carcinogens...; Region: GST_N_Beta; cd03057 114615016610 C-terminal domain interface [polypeptide binding]; other site 114615016611 GSH binding site (G-site) [chemical binding]; other site 114615016612 dimer interface [polypeptide binding]; other site 114615016613 C-terminal, alpha helical domain of Class Beta Glutathione S-transferases; Region: GST_C_Beta; cd03188 114615016614 N-terminal domain interface [polypeptide binding]; other site 114615016615 dimer interface [polypeptide binding]; other site 114615016616 substrate binding pocket (H-site) [chemical binding]; other site 114615016617 Plasmid stabilisation system protein; Region: Plasmid_stabil; cl11422 114615016618 Putative addiction module component; Region: Unstab_antitox; cl09921 114615016619 multifunctional fatty acid oxidation complex subunit alpha; Reviewed; Region: fadJ; PRK11154 114615016620 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase...; Region: crotonase-like; cd06558 114615016621 substrate binding site [chemical binding]; other site 114615016622 oxyanion hole (OAH) forming residues; other site 114615016623 trimer interface [polypeptide binding]; other site 114615016624 NAD-dependent, lactate dehydrogenase-like, 2-hydroxycarboxylate dehydrogenase family; Region: LDH_MDH_like; cl11406 114615016625 LDH/MDH dimer interface [polypeptide binding]; other site 114615016626 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 114615016627 acetyl-CoA acetyltransferase; Validated; Region: PRK08242 114615016628 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 114615016629 dimer interface [polypeptide binding]; other site 114615016630 active site 114615016631 acyl-CoA dehydrogenase; Provisional; Region: PTZ00456 114615016632 Acyl-CoA dehydrogenase N terminal; Region: AcylCoA_DH_N; pfam12418 114615016633 Putative acyl-CoA dehydrogenases similar to fadE5; Region: ACAD_fadE5; cd01153 114615016634 FAD binding site [chemical binding]; other site 114615016635 substrate binding site [chemical binding]; other site 114615016636 catalytic residues [active] 114615016637 Acetyl-CoA dehydrogenase C-terminal like; Region: Acyl-CoA_dh_C; pfam12806 114615016638 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109 114615016639 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 114615016640 Virulence activator alpha C-term; Region: Vir_act_alpha_C; pfam10400 114615016641 chromosome segregation protein SMC, primarily archaeal type; Region: SMC_prok_A; TIGR02169 114615016642 Sel1 repeat; Region: Sel1; cl02723 114615016643 Sel1 repeat; Region: Sel1; cl02723 114615016644 Sel1 repeat; Region: Sel1; cl02723 114615016645 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase...; Region: crotonase-like; cl14780 114615016646 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 114615016647 Putative transmembrane protein (Alph_Pro_TM); Region: Alph_Pro_TM; cl09826 114615016648 putative DMT superfamily transporter inner membrane protein; Provisional; Region: PRK11272 114615016649 EamA-like transporter family; Region: EamA; cl01037 114615016650 EamA-like transporter family; Region: EamA; cl01037 114615016651 Transcriptional regulator [Transcription]; Region: LysR; COG0583 114615016652 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 114615016653 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 114615016654 dimerization interface [polypeptide binding]; other site 114615016655 Pyrococcus furiosus PF1019 and related proteins, metallophosphatase domain; Region: MPP_PF1019; cd07391 114615016656 putative active site [active] 114615016657 putative metal binding site [ion binding]; other site 114615016658 Lhr-like helicases [General function prediction only]; Region: Lhr; COG1201 114615016659 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 114615016660 ATP binding site [chemical binding]; other site 114615016661 putative Mg++ binding site [ion binding]; other site 114615016662 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 114615016663 nucleotide binding region [chemical binding]; other site 114615016664 ATP-binding site [chemical binding]; other site 114615016665 DEAD/H associated; Region: DEAD_assoc; pfam08494 114615016666 ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683 114615016667 Type I periplasmic ligand-binding domain of uncharacterized ABC (ATPase Binding Cassette)-type active transport systems that are predicted to be involved in uptake of amino acids, peptides, or inorganic ions; Region: PBP1_ABC_ligand_binding_like_8; cd06343 114615016668 putative ligand binding site [chemical binding]; other site 114615016669 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi...; Region: TPR; cd00189 114615016670 binding surface 114615016671 Predicted methyltransferase (contains TPR repeat) [General function prediction only]; Region: COG4976 114615016672 TPR motif; other site 114615016673 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cd02440 114615016674 S-adenosylmethionine binding site [chemical binding]; other site 114615016675 Predicted exonuclease of the beta-lactamase fold involved in RNA processing [Translation, ribosomal structure and biogenesis]; Region: YSH1; COG1236 114615016676 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 114615016677 ATP-dependent DNA ligase; Validated; Region: PRK09247 114615016678 Adenylation domain of putative bacterial ATP-dependent DNA ligases; Region: Adenylation_DNA_ligase_Bac1; cd07897 114615016679 DNA polymerase LigD, ligase domain; Region: NHEJ_ligase_lig; TIGR02779 114615016680 active site 114615016681 DNA binding site [nucleotide binding] 114615016682 The Oligonucleotide/oligosaccharide binding (OB)-fold domain of archaeal and bacterial ATP-dependent DNA ligases is a DNA-binding module that is part of the catalytic core unit; Region: OBF_DNA_ligase_Arch_LigB; cd07972 114615016683 DNA binding site [nucleotide binding] 114615016684 DNA-damage-inducible SOS response protein; Provisional; Region: PRK10367 114615016685 MatE; Region: MatE; cl10513 114615016686 MatE; Region: MatE; cl10513 114615016687 Dihydroorotate dehydrogenase (DHOD) class 2. DHOD catalyzes the oxidation of (S)-dihydroorotate to orotate. This is the fourth step and the only redox reaction in the de novo biosynthesis of UMP, the precursor of all pyrimidine nucleotides. DHOD...; Region: DHOD_2_like; cd04738 114615016688 quinone interaction residues [chemical binding]; other site 114615016689 Dihydroorotate dehydrogenase [Nucleotide transport and metabolism]; Region: PyrD; COG0167 114615016690 active site 114615016691 catalytic residues [active] 114615016692 FMN binding site [chemical binding]; other site 114615016693 substrate binding site [chemical binding]; other site 114615016694 Protein of unknown function (DUF952); Region: DUF952; cl01393 114615016695 Carbonic anhydrase alpha, prokaryotic-like subfamily. Carbonic anhydrases (CAs) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism: a nucleophilic attack of a zinc-bound hydroxide ion on carbon...; Region: alpha_CA_prokaryotic_like; cd03124 114615016696 active site 114615016697 zinc binding site [ion binding]; other site 114615016698 lysyl-tRNA synthetase; Reviewed; Region: lysK; PRK00750 114615016699 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 114615016700 active site 114615016701 nucleotide binding site [chemical binding]; other site 114615016702 HIGH motif; other site 114615016703 KMSKS motif; other site 114615016704 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and...; Region: PBPb; cd00134 114615016705 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 114615016706 substrate binding pocket [chemical binding]; other site 114615016707 membrane-bound complex binding site; other site 114615016708 hinge residues; other site 114615016709 SCO (an acronym for Synthesis of Cytochrome c Oxidase) family; composed of proteins similar to Sco1, a membrane-anchored protein possessing a soluble domain with a TRX fold. Members of this family are required for the proper assembly of cytochrome c...; Region: SCO; cd02968 114615016710 Cu(I) binding site [ion binding]; other site 114615016711 Acyl-protein synthetase, LuxE; Region: LuxE; cl10450 114615016712 Transcriptional regulators [Transcription]; Region: PurR; COG1609 114615016713 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 114615016714 DNA binding site [nucleotide binding] 114615016715 domain linker motif; other site 114615016716 Ligand-binding domain of DNA transcription repressor GntR specific for gluconate, a member of the LacI-GalR family of bacterial transcription regulators; Region: PBP1_GntR; cd01575 114615016717 putative dimerization interface [polypeptide binding]; other site 114615016718 putative ligand binding site [chemical binding]; other site 114615016719 ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129 114615016720 This family represents the domain I of the carbohydrate uptake proteins that transport only monosaccharides (Monos). The Carb_Monos family is involved in the uptake of monosaccharides, such as pentoses (such as xylose, arabinose, and ribose) and...; Region: ABC_Carb_Monos_I; cd03216 114615016721 Walker A/P-loop; other site 114615016722 ATP binding site [chemical binding]; other site 114615016723 Q-loop/lid; other site 114615016724 ABC transporter signature motif; other site 114615016725 Walker B; other site 114615016726 D-loop; other site 114615016727 H-loop/switch region; other site 114615016728 This family represents domain II of the carbohydrate uptake proteins that transport only monosaccharides (Monos). The Carb_Monos family is involved in the uptake of monosaccharides, such as pentoses (such as xylose, arabinose, and ribose) and hexoses (; Region: ABC_Carb_Monos_II; cd03215 114615016729 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 114615016730 TM-ABC transporter signature motif; other site 114615016731 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 114615016732 Antibiotic biosynthesis monooxygenase; Region: ABM; cl10022 114615016733 Gluconolactonase [Carbohydrate transport and metabolism]; Region: COG3386 114615016734 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084 114615016735 gluconate 5-dehydrogenase (Ga5DH)-like, classical (c) SDRs; Region: Ga5DH-like_SDR_c; cd05347 114615016736 gluconate 5-dehydrogenase; Provisional; Region: PRK06124 114615016737 NADP binding site [chemical binding]; other site 114615016738 homodimer interface [polypeptide binding]; other site 114615016739 active site 114615016740 Methylated DNA-protein cysteine methyltransferase [DNA replication, recombination, and repair]; Region: Ada; COG0350 114615016741 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 114615016742 DNA binding site [nucleotide binding] 114615016743 active site 114615016744 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 114615016745 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 114615016746 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_19; cd07262 114615016747 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643 114615016748 hydrophobic ligand binding site; other site 114615016749 putative efflux protein, MATE family; Region: matE; TIGR00797 114615016750 MatE; Region: MatE; cl10513 114615016751 MatE; Region: MatE; cl10513 114615016752 2'-deoxycytidine 5'-triphosphate deaminase; Provisional; Region: PRK07559 114615016753 Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cl00493 114615016754 Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557 114615016755 trimer interface [polypeptide binding]; other site 114615016756 active site 114615016757 Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cl00493 114615016758 O-succinylhomoserine sulfhydrylase; Reviewed; Region: PRK07504 114615016759 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 114615016760 homodimer interface [polypeptide binding]; other site 114615016761 substrate-cofactor binding pocket; other site 114615016762 pyridoxal 5'-phosphate binding site [chemical binding]; other site 114615016763 catalytic residue [active] 114615016764 SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cd00229 114615016765 active site 114615016766 catalytic triad [active] 114615016767 oxyanion hole [active] 114615016768 SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cl01053 114615016769 active site 114615016770 oxyanion hole [active] 114615016771 OpgC protein; Region: OpgC_C; cl10497 114615016772 Protein of unknown function (DUF525); Region: DUF525; cl01119 114615016773 Heat shock protein 33 (Hsp33): Cytosolic protein that acts as a molecular chaperone under oxidative conditions. In normal (reducing) cytosolic conditions, four conserved Cys residues are coordinated by a Zn ion. Under oxidative stress (such as heat...; Region: Hsp33; cd00498 114615016774 Hsp33-like chaperonin; Reviewed; Region: hslO; PRK00114 114615016775 dimerization interface [polypeptide binding]; other site 114615016776 domain crossover interface; other site 114615016777 redox-dependent activation switch; other site 114615016778 Domain of unknown function, appears to be related to a diverse group of endonucleases; Region: Endonuclease_DUF559; cd01038 114615016779 putative active site [active] 114615016780 ornithine carbamoyltransferase; Provisional; Region: PRK00779 114615016781 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 114615016782 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 114615016783 acetylornithine transaminase protein; Provisional; Region: argD; PRK01278 114615016784 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase...; Region: OAT_like; cd00610 114615016785 inhibitor-cofactor binding pocket; inhibition site 114615016786 pyridoxal 5'-phosphate binding site [chemical binding]; other site 114615016787 catalytic residue [active] 114615016788 GcrA cell cycle regulator; Region: GcrA; cl11564 114615016789 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 114615016790 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via trans-...; Region: HisKA; cd00082 114615016791 dimer interface [polypeptide binding]; other site 114615016792 phosphorylation site [posttranslational modification] 114615016793 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 114615016794 ATP binding site [chemical binding]; other site 114615016795 Mg2+ binding site [ion binding]; other site 114615016796 G-X-G motif; other site 114615016797 Predicted integral membrane protein [Function unknown]; Region: COG0392 114615016798 Uncharacterised protein family (UPF0104); Region: UPF0104; cl04219 114615016799 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 114615016800 ligand binding site [chemical binding]; other site 114615016801 Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726 114615016802 Polysaccharide deacetylase; Region: Polysacc_deac_1; cl12061 114615016803 Polysaccharide deacetylase; Region: Polysacc_deac_1; cl12061 114615016804 gluconate 5-dehydrogenase; Provisional; Region: PRK08213 114615016805 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 114615016806 NAD(P) binding site [chemical binding]; other site 114615016807 active site 114615016808 Phenylacetic acid catabolic protein; Region: PaaA_PaaC; cl01346 114615016809 benzoyl-CoA-dihydrodiol lyase; Provisional; Region: PRK08184 114615016810 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase...; Region: crotonase-like; cd06558 114615016811 substrate binding site [chemical binding]; other site 114615016812 oxyanion hole (OAH) forming residues; other site 114615016813 trimer interface [polypeptide binding]; other site 114615016814 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase...; Region: crotonase-like; cd06558 114615016815 substrate binding site [chemical binding]; other site 114615016816 trimer interface [polypeptide binding]; other site 114615016817 oxyanion hole (OAH) forming residues; other site 114615016818 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 114615016819 benzoate-CoA ligase family; Region: benz_CoA_lig; TIGR02262 114615016820 Acyl-protein synthetase, LuxE; Region: LuxE; cl10450 114615016821 anaerobic benzoate catabolism transcriptional regulator; Reviewed; Region: PRK08154 114615016822 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 114615016823 non-specific DNA binding site [nucleotide binding]; other site 114615016824 salt bridge; other site 114615016825 sequence-specific DNA binding site [nucleotide binding]; other site 114615016826 Shikimate kinase (SK) is the fifth enzyme in the shikimate pathway, a seven-step biosynthetic pathway which converts erythrose-4-phosphate to chorismic acid, found in bacteria, fungi and plants. Chorismic acid is a important intermediate in the...; Region: SK; cd00464 114615016827 ADP binding site [chemical binding]; other site 114615016828 magnesium binding site [ion binding]; other site 114615016829 putative shikimate binding site; other site 114615016830 Arginase family; Region: Arginase; cl00306 114615016831 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 114615016832 NrtD and SsuB are the ATP-binding subunits of the bacterial ABC-type nitrate and sulfonate transport systems, respectively. ABC transporters are a large family of proteins involved in the transport of a wide variety of different compounds, like sugars...; Region: ABC_NrtD_SsuB_transporters; cd03293 114615016833 Walker A/P-loop; other site 114615016834 ATP binding site [chemical binding]; other site 114615016835 Q-loop/lid; other site 114615016836 ABC transporter signature motif; other site 114615016837 Walker B; other site 114615016838 D-loop; other site 114615016839 H-loop/switch region; other site 114615016840 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261 114615016841 dimer interface [polypeptide binding]; other site 114615016842 conserved gate region; other site 114615016843 putative PBP binding loops; other site 114615016844 ABC-ATPase subunit interface; other site 114615016845 Tripartite tricarboxylate transporter family receptor; Region: TctC; cl15260 114615016846 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410 114615016847 LivF (TM1139) is part of the LIV-I bacterial ABC-type two-component transport system that imports neutral, branched-chain amino acids. The E. coli branched-chain amino acid transporter comprises a heterodimer of ABC transporters (LivF and LivG), a...; Region: ABC_TM1139_LivF_branched; cd03224 114615016848 Walker A/P-loop; other site 114615016849 ATP binding site [chemical binding]; other site 114615016850 Q-loop/lid; other site 114615016851 ABC transporter signature motif; other site 114615016852 Walker B; other site 114615016853 D-loop; other site 114615016854 H-loop/switch region; other site 114615016855 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411 114615016856 The Mj1267/LivG ABC transporter subfamily is involved in the transport of the hydrophobic amino acids leucine, isoleucine and valine. MJ1267 is a branched-chain amino acid transporter with 29% similarity to both the LivF and LivG components of the E...; Region: ABC_Mj1267_LivG_branched; cd03219 114615016857 Walker A/P-loop; other site 114615016858 ATP binding site [chemical binding]; other site 114615016859 Q-loop/lid; other site 114615016860 ABC transporter signature motif; other site 114615016861 Walker B; other site 114615016862 D-loop; other site 114615016863 H-loop/switch region; other site 114615016864 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 114615016865 TM-ABC transporter signature motif; other site 114615016866 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 114615016867 TM-ABC transporter signature motif; other site 114615016868 ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683 114615016869 Type I periplasmic binding component of active transport systems that are predicted to be involved in 2-nitrobenzoic acid degradation pathway; Region: PBP1_Nba_like; cd06359 114615016870 putative ligand binding site [chemical binding]; other site 114615016871 ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683 114615016872 Periplasmic solute-binding domain of active transport proteins that belong to the type I periplasmic binding fold protein family; Region: PBP1_SBP_like_1; cd06327 114615016873 putative ligand binding site [chemical binding]; other site 114615016874 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 114615016875 catalytic loop [active] 114615016876 iron binding site [ion binding]; other site 114615016877 Cytochrome P450; Region: p450; cl12078 114615016878 Transcriptional regulators [Transcription]; Region: MarR; COG1846 114615016879 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 114615016880 NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252 114615016881 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 114615016882 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 114615016883 allophanate hydrolase; Provisional; Region: PRK08186 114615016884 GGCT-like domains, also called AIG2-like family. Gamma-glutamyl cyclotransferase (GGCT) catalyzes the formation of pyroglutamic acid (5-oxoproline) from dipeptides containing gamma-glutamyl, and is a dimeric protein. In Homo sapiens, the protein is...; Region: GGCT_like; cl11426 114615016885 Transposase domain (DUF772); Region: DUF772; cl12084 114615016886 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 114615016887 Transcriptional regulators [Transcription]; Region: GntR; COG1802 114615016888 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 114615016889 DNA-binding site [nucleotide binding]; DNA binding site 114615016890 FCD domain; Region: FCD; cl11656 114615016891 Protein of unknown function (DUF3225); Region: DUF3225; pfam11533 114615016892 amidase; Provisional; Region: PRK09201 114615016893 GGCT-like domains, also called AIG2-like family. Gamma-glutamyl cyclotransferase (GGCT) catalyzes the formation of pyroglutamic acid (5-oxoproline) from dipeptides containing gamma-glutamyl, and is a dimeric protein. In Homo sapiens, the protein is...; Region: GGCT_like; cl11426 114615016894 ATPase components of various ABC-type transport systems, contain duplicated ATPase [General function prediction only]; Region: COG1123 114615016895 The ABC transporter subfamily specific for the transport of dipeptides, oligopeptides (OppD), and nickel (NikDE). The NikABCDE system of E. coli belongs to this family and is composed of the periplasmic binding protein NikA, two integral membrane...; Region: ABC_NikE_OppD_transporters; cd03257 114615016896 Walker A/P-loop; other site 114615016897 ATP binding site [chemical binding]; other site 114615016898 Q-loop/lid; other site 114615016899 ABC transporter signature motif; other site 114615016900 Walker B; other site 114615016901 D-loop; other site 114615016902 H-loop/switch region; other site 114615016903 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 114615016904 The ABC transporter subfamily specific for the transport of dipeptides, oligopeptides (OppD), and nickel (NikDE). The NikABCDE system of E. coli belongs to this family and is composed of the periplasmic binding protein NikA, two integral membrane...; Region: ABC_NikE_OppD_transporters; cd03257 114615016905 Walker A/P-loop; other site 114615016906 ATP binding site [chemical binding]; other site 114615016907 Q-loop/lid; other site 114615016908 ABC transporter signature motif; other site 114615016909 Walker B; other site 114615016910 D-loop; other site 114615016911 H-loop/switch region; other site 114615016912 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 114615016913 N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911 114615016914 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261 114615016915 dimer interface [polypeptide binding]; other site 114615016916 conserved gate region; other site 114615016917 putative PBP binding loops; other site 114615016918 ABC-ATPase subunit interface; other site 114615016919 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 114615016920 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261 114615016921 dimer interface [polypeptide binding]; other site 114615016922 conserved gate region; other site 114615016923 putative PBP binding loops; other site 114615016924 ABC-ATPase subunit interface; other site 114615016925 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_7; cd08512 114615016926 Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496 114615016927 Caspase, interleukin-1 beta converting enzyme (ICE) homologues; Cysteine-dependent aspartate-directed proteases that mediate programmed cell death (apoptosis). Caspases are synthesized as inactive zymogens and activated by proteolysis of the peptide...; Region: CASc; cl00042 114615016928 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cd05120 114615016929 active site 114615016930 ATP binding site [chemical binding]; other site 114615016931 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 114615016932 active site 114615016933 ATP binding site [chemical binding]; other site 114615016934 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 114615016935 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 114615016936 Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices connected by an extended linker. The...; Region: HAMP; cl01054 114615016937 Signal transduction histidine kinase regulating C4-dicarboxylate transport system [Signal transduction mechanisms]; Region: COG4191 114615016938 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 114615016939 ATP binding site [chemical binding]; other site 114615016940 Mg2+ binding site [ion binding]; other site 114615016941 G-X-G motif; other site 114615016942 Response regulator receiver domain; Region: Response_reg; pfam00072 114615016943 Domain of unknown function (DUF3369); Region: DUF3369; pfam11849 114615016944 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 114615016945 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via trans-...; Region: HisKA; cd00082 114615016946 dimer interface [polypeptide binding]; other site 114615016947 phosphorylation site [posttranslational modification] 114615016948 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 114615016949 ATP binding site [chemical binding]; other site 114615016950 Mg2+ binding site [ion binding]; other site 114615016951 G-X-G motif; other site 114615016952 osmolarity response regulator; Provisional; Region: ompR; PRK09468 114615016953 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156 114615016954 active site 114615016955 phosphorylation site [posttranslational modification] 114615016956 intermolecular recognition site; other site 114615016957 dimerization interface [polypeptide binding]; other site 114615016958 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase...; Region: trans_reg_C; cd00383 114615016959 DNA binding site [nucleotide binding] 114615016960 RNA polymerase sigma factor; Provisional; Region: PRK12515 114615016961 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 114615016962 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial...; Region: Sigma70_r4; cd06171 114615016963 DNA binding residues [nucleotide binding] 114615016964 Bacterial Cytochrome Ubiquinol Oxidase; Region: Bac_Ubq_Cox; cl00562 114615016965 Cytochrome oxidase subunit II; Region: Cyto_ox_2; pfam02322 114615016966 cytochrome d ubiquinol oxidase subunit 2; Provisional; Region: PRK15003; cl12219 114615016967 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 114615016968 Bacterial periplasmic substrate-binding proteins; Region: PBPb; smart00062 114615016969 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and...; Region: PBPb; cd00134 114615016970 substrate binding pocket [chemical binding]; other site 114615016971 membrane-bound complex binding site; other site 114615016972 hinge residues; other site 114615016973 Fasciclin domain; Region: Fasciclin; cl02663 114615016974 pimeloyl-CoA dehydrogenase, small subunit; Region: pimD_small; TIGR03203 114615016975 Acyl-CoA dehydrogenase; Region: ACAD; cd00567 114615016976 active site 114615016977 pimeloyl-CoA dehydrogenase, large subunit; Region: pimC_large; TIGR03204 114615016978 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 114615016979 active site 114615016980 drug resistance transporter, Bcr/CflA subfamily; Region: efflux_Bcr_CflA; TIGR00710 114615016981 Serine proteases of the peptidase family S9A [Amino acid transport and metabolism]; Region: COG1505 114615016982 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 114615016983 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cl12011 114615016984 Cytochrome c; Region: Cytochrom_C; cl11414 114615016985 Predicted secreted protein [Function unknown]; Region: COG5501; cl02313 114615016986 Sulphur oxidation protein SoxZ; Region: SoxZ; pfam08770 114615016987 Cytochrome c [Energy production and conversion]; Region: COG3258 114615016988 Cytochrome c [Energy production and conversion]; Region: COG3258 114615016989 Thermus thermophilus SoxB and related proteins, N-terminal metallophosphatase domain; Region: MPP_SoxB_N; cd07411 114615016990 active site 114615016991 metal binding site [ion binding]; metal-binding site 114615016992 5'-nucleotidase/2',3'-cyclic phosphodiesterase and related esterases [Nucleotide transport and metabolism]; Region: UshA; COG0737 114615016993 5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872 114615016994 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 114615016995 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cl00125 114615016996 active site residue [active] 114615016997 choline dehydrogenase; Validated; Region: PRK02106 114615016998 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 114615016999 ABC transporter, substrate-binding protein, aliphatic sulfonates family; Region: SsuA_fam; TIGR01728 114615017000 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and...; Region: PBPb; cd00134 114615017001 substrate binding pocket [chemical binding]; other site 114615017002 membrane-bound complex binding site; other site 114615017003 Tripartite tricarboxylate transporter family receptor; Region: TctC; cl15260 114615017004 ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components [Inorganic ion transport and metabolism]; Region: TauA; COG0715 114615017005 Tripartite tricarboxylate transporter family receptor; Region: TctC; cl15260 114615017006 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and...; Region: PBPb; cd00134 114615017007 substrate binding pocket [chemical binding]; other site 114615017008 membrane-bound complex binding site; other site 114615017009 hinge residues; other site 114615017010 NrtD and SsuB are the ATP-binding subunits of the bacterial ABC-type nitrate and sulfonate transport systems, respectively. ABC transporters are a large family of proteins involved in the transport of a wide variety of different compounds, like sugars...; Region: ABC_NrtD_SsuB_transporters; cd03293 114615017011 nitrate transport ATP-binding subunits C and D; Region: ntrCD; TIGR01184 114615017012 Walker A/P-loop; other site 114615017013 ATP binding site [chemical binding]; other site 114615017014 Q-loop/lid; other site 114615017015 ABC transporter signature motif; other site 114615017016 Walker B; other site 114615017017 D-loop; other site 114615017018 H-loop/switch region; other site 114615017019 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 114615017020 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261 114615017021 dimer interface [polypeptide binding]; other site 114615017022 conserved gate region; other site 114615017023 putative PBP binding loops; other site 114615017024 ABC-ATPase subunit interface; other site 114615017025 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 114615017026 N-acyl-D-aspartate/D-glutamate deacylase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3653 114615017027 D-aminoacylases (N-acyl-D-Amino acid amidohydrolases) catalyze the hydrolysis of N-acyl-D-amino acids to produce the corresponding D-amino acids, which are used as intermediates in the synthesis of pesticides, bioactive peptides, and antibiotics; Region: D-aminoacylase; cd01297 114615017028 active site 114615017029 putative substrate binding pocket [chemical binding]; other site 114615017030 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have...; Region: metallo-dependent_hydrolases; cl00281 114615017031 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 114615017032 D-galactonate transporter; Region: 2A0114; TIGR00893 114615017033 putative substrate translocation pore; other site 114615017034 This family is comprised of MJ0796 ATP-binding cassette, macrolide-specific ABC-type efflux carrier (MacAB), and proteins involved in cell division (FtsE), and release of liporoteins from the cytoplasmic membrane (LolCDE). They are clustered together...; Region: ABC_MJ0796_Lo1CDE_FtsE; cd03255 114615017035 cobalt transport protein ATP-binding subunit; Region: cbiO; TIGR01166 114615017036 Walker A/P-loop; other site 114615017037 ATP binding site [chemical binding]; other site 114615017038 Q-loop/lid; other site 114615017039 ABC transporter signature motif; other site 114615017040 Walker B; other site 114615017041 D-loop; other site 114615017042 H-loop/switch region; other site 114615017043 Predicted ABC-type transport system involved in lysophospholipase L1 biosynthesis, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3127 114615017044 FtsX-like permease family; Region: FtsX; pfam02687 114615017045 Hydroxyneurosporene synthase (CrtC); Region: CrtC; cl12101 114615017046 MAPEG family; Region: MAPEG; cl09190 114615017047 ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683 114615017048 Periplasmic solute-binding domain of active transport proteins that belong to the type I periplasmic binding fold protein family; Region: PBP1_SBP_like_1; cd06327 114615017049 putative ligand binding site [chemical binding]; other site 114615017050 acyl-CoA synthetase; Provisional; Region: PRK13391 114615017051 Acyl-protein synthetase, LuxE; Region: LuxE; cl10450 114615017052 FOG: CBS domain [General function prediction only]; Region: COG0517 114615017053 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the BON (bacterial OsmY and nodulation domain) domain. BON is a putative phospholipid-binding domain found in a family of osmotic shock protection...; Region: CBS_pair_BON_assoc; cd04586 114615017054 BON domain; Region: BON; cl02771 114615017055 PAS domain S-box; Region: sensory_box; TIGR00229 114615017056 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 114615017057 putative active site [active] 114615017058 heme pocket [chemical binding]; other site 114615017059 PAS domain S-box; Region: sensory_box; TIGR00229 114615017060 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 114615017061 putative active site [active] 114615017062 heme pocket [chemical binding]; other site 114615017063 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920 114615017064 Histidine kinase; Region: HisKA_2; cl06527 114615017065 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156 114615017066 active site 114615017067 phosphorylation site [posttranslational modification] 114615017068 intermolecular recognition site; other site 114615017069 dimerization interface [polypeptide binding]; other site 114615017070 Acetyl/propionyl-CoA carboxylase, alpha subunit [Lipid metabolism]; Region: COG4770 114615017071 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 114615017072 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; cl03087 114615017073 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; cl08365 114615017074 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase...; Region: biotinyl_domain; cd06850 114615017075 carboxyltransferase (CT) interaction site; other site 114615017076 biotinylation site [posttranslational modification]; other site 114615017077 3-methylcrotonyl-CoA carboxylase, beta chain; Region: PLN02820 114615017078 Acetyl co-enzyme A carboxylase carboxyltransferase alpha subunit; Region: ACCA; cl00513 114615017079 Acetyl co-enzyme A carboxylase carboxyltransferase alpha subunit; Region: ACCA; cl00513 114615017080 Prokaryotic protein of unknown function (DUF849); Region: DUF849; cl01276 114615017081 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 114615017082 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 114615017083 GST_N family, Saccharomyces cerevisiae GTT1-like subfamily; composed of predominantly uncharacterized proteins with similarity to the S. cerevisiae GST protein, GTT1, and the Schizosaccharomyces pombe GST-III. GSTs are cytosolic dimeric proteins...; Region: GST_N_GTT1_like; cd03046 114615017084 putative C-terminal domain interface [polypeptide binding]; other site 114615017085 putative GSH binding site (G-site) [chemical binding]; other site 114615017086 putative dimer interface [polypeptide binding]; other site 114615017087 C-terminal, alpha helical domain of the Glutathione S-transferase family; Region: GST_C_family; cl02776 114615017088 N-terminal domain interface [polypeptide binding]; other site 114615017089 dimer interface [polypeptide binding]; other site 114615017090 substrate binding pocket (H-site) [chemical binding]; other site 114615017091 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 114615017092 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 114615017093 active site 114615017094 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 114615017095 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 114615017096 active site 114615017097 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK06187 114615017098 Acyl-protein synthetase, LuxE; Region: LuxE; cl10450 114615017099 ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683 114615017100 Type I periplasmic ligand-binding domain of uncharacterized ABC (ATPase Binding Cassette)-type active transport systems that are predicted to be involved in uptake of amino acids, peptides, or inorganic ions; Region: PBP1_ABC_ligand_binding_like_8; cd06343 114615017101 putative ligand binding site [chemical binding]; other site 114615017102 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl15258 114615017103 marine proteobacterial sortase target protein; Region: marine_srt_targ; TIGR03788 114615017104 Vault protein inter-alpha-trypsin; Region: VIT; cl02699 114615017105 vWA_interalpha trypsin inhibitor (ITI): ITI is a glycoprotein composed of three polypeptides- two heavy chains and one light chain (bikunin). Bikunin confers the protease-inhibitor function while the heavy chains are involved in rendering stability to...; Region: vWA_interalpha_trypsin_inhibitor; cd01461 114615017106 metal ion-dependent adhesion site (MIDAS); other site 114615017107 Sortase D (SrtD) is a membrane transpeptidase found in gram-positive bacteria that anchors surface proteins to peptidoglycans of the bacterial cell wall envelope. This involves a transpeptidation reaction in which the surface protein substrate is...; Region: Sortase_D_4; cd05828 114615017108 active site 114615017109 catalytic site [active] 114615017110 Protein of unknown function (DUF1614); Region: DUF1614; pfam07758 114615017111 mce related protein; Region: MCE; pfam02470 114615017112 Cytochrome b562; Region: Cytochrom_B562; cl01546 114615017113 Zinc ribbon domain; Region: CxxC_CxxC_SSSS; cl00993 114615017114 Acetamidase/Formamidase family; Region: FmdA_AmdA; cl01023 114615017115 urea ABC transporter, ATP-binding protein UrtE; Region: urea_trans_UrtE; TIGR03410 114615017116 LivF (TM1139) is part of the LIV-I bacterial ABC-type two-component transport system that imports neutral, branched-chain amino acids. The E. coli branched-chain amino acid transporter comprises a heterodimer of ABC transporters (LivF and LivG), a...; Region: ABC_TM1139_LivF_branched; cd03224 114615017117 Walker A/P-loop; other site 114615017118 ATP binding site [chemical binding]; other site 114615017119 Q-loop/lid; other site 114615017120 ABC transporter signature motif; other site 114615017121 Walker B; other site 114615017122 D-loop; other site 114615017123 H-loop/switch region; other site 114615017124 urea ABC transporter, ATP-binding protein UrtD; Region: urea_trans_UrtD; TIGR03411 114615017125 The Mj1267/LivG ABC transporter subfamily is involved in the transport of the hydrophobic amino acids leucine, isoleucine and valine. MJ1267 is a branched-chain amino acid transporter with 29% similarity to both the LivF and LivG components of the E...; Region: ABC_Mj1267_LivG_branched; cd03219 114615017126 Walker A/P-loop; other site 114615017127 ATP binding site [chemical binding]; other site 114615017128 Q-loop/lid; other site 114615017129 ABC transporter signature motif; other site 114615017130 Walker B; other site 114615017131 D-loop; other site 114615017132 H-loop/switch region; other site 114615017133 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 114615017134 TM-ABC transporter signature motif; other site 114615017135 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 114615017136 TM-ABC transporter signature motif; other site 114615017137 ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683 114615017138 Periplasmic component (FmdD) of an active transport system for short-chain amides and urea (FmdDEF); Region: PBP1_FmdD_like; cd06355 114615017139 putative ligand binding site [chemical binding]; other site 114615017140 Sodium:solute symporter family; Region: SSF; cl00456 114615017141 Purine-cytosine permease and related proteins [Nucleotide transport and metabolism]; Region: CodB; COG1457 114615017142 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via trans-...; Region: HisKA; cd00082 114615017143 dimer interface [polypeptide binding]; other site 114615017144 phosphorylation site [posttranslational modification] 114615017145 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 114615017146 ATP binding site [chemical binding]; other site 114615017147 Mg2+ binding site [ion binding]; other site 114615017148 G-X-G motif; other site 114615017149 Response regulator receiver domain; Region: Response_reg; pfam00072 114615017150 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156 114615017151 active site 114615017152 phosphorylation site [posttranslational modification] 114615017153 intermolecular recognition site; other site 114615017154 dimerization interface [polypeptide binding]; other site 114615017155 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156 114615017156 Response regulator receiver domain; Region: Response_reg; pfam00072 114615017157 active site 114615017158 phosphorylation site [posttranslational modification] 114615017159 intermolecular recognition site; other site 114615017160 dimerization interface [polypeptide binding]; other site 114615017161 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors...; Region: LuxR_C_like; cd06170 114615017162 DNA binding residues [nucleotide binding] 114615017163 dimerization interface [polypeptide binding]; other site 114615017164 Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072 114615017165 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 114615017166 NAD(P) binding pocket [chemical binding]; other site 114615017167 Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic...; Region: Tryp_SPc; cl00149 114615017168 active site 114615017169 substrate binding sites [chemical binding]; other site 114615017170 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others...; Region: HAD_like; cl11391 114615017171 haloacid dehalogenase-like hydrolase; Region: Hydrolase; pfam00702 114615017172 Predicted translation initiation factor 2B subunit, eIF-2B alpha/beta/delta family [Translation, ribosomal structure and biogenesis]; Region: COG0182; cl00348 114615017173 Initiation factor 2 subunit family; Region: IF-2B; pfam01008 114615017174 Phosphorylase superfamily; Region: PNP_UDP_1; cl00303 114615017175 Phosphopantetheine attachment site; Region: PP-binding; cl09936 114615017176 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 114615017177 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 114615017178 active site 114615017179 Gly_His_Pro_Ser_Thr_tRNA synthetase class II core domain. This domain is the core catalytic domain of tRNA synthetases of the subgroup containing glycyl, histidyl, prolyl, seryl and threonyl tRNA synthetases. It is primarily responsible for ATP-...; Region: Gly_His_Pro_Ser_Thr_tRS_core; cd00670 114615017180 dimer interface [polypeptide binding]; other site 114615017181 motif 1; other site 114615017182 active site 114615017183 motif 2; other site 114615017184 motif 3; other site 114615017185 PyridoxaL 5'-Phosphate Dependent Enzymes class IV (PLPDE_IV). This D-amino acid superfamily, one of five classes of PLPDE, consists of branched-chain amino acid aminotransferases (BCAT), D-amino acid transferases (DAAT), and 4-amino-4-deoxychorismate...; Region: PLPDE_IV; cl00224 114615017186 homodimer interface [polypeptide binding]; other site 114615017187 substrate-cofactor binding pocket; other site 114615017188 Aminotransferase class IV; Region: Aminotran_4; pfam01063 114615017189 pyridoxal 5'-phosphate binding site [chemical binding]; other site 114615017190 catalytic residue [active] 114615017191 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 114615017192 OAH/OAS sulfhydrylase; Region: OAH_OAS_sulfhy; TIGR01326 114615017193 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 114615017194 homodimer interface [polypeptide binding]; other site 114615017195 substrate-cofactor binding pocket; other site 114615017196 pyridoxal 5'-phosphate binding site [chemical binding]; other site 114615017197 catalytic residue [active] 114615017198 Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GAT_1; cl00020 114615017199 conserved cys residue [active] 114615017200 bifunctional proline dehydrogenase/pyrroline-5-carboxylate dehydrogenase; Reviewed; Region: PRK11904 114615017201 Proline dehydrogenase; Region: Pro_dh; cl03282 114615017202 Delta(1)-pyrroline-5-carboxylate dehydrogenase, PutA; Region: ALDH_PutA-P5CDH; cd07125 114615017203 Glutamate binding site [chemical binding]; other site 114615017204 NAD binding site [chemical binding]; other site 114615017205 catalytic residues [active] 114615017206 Protein of unknown function (DUF763); Region: DUF763; cl00620 114615017207 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or...; Region: Nudix_Hydrolase; cl00447 114615017208 nudix motif; other site 114615017209 Cache domain; Region: Cache_2; cl07034 114615017210 Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices connected by an extended linker. The...; Region: HAMP; cl01054 114615017211 Taxis toward Aspartate and Related amino acids and Homologs (TarH). The Tar chemoreceptor of Escherichia coli mediates attractant responses to aspartate, maltose, and phenol, repellent responses to Ni2+ and Co2+, and thermoresponses. These...; Region: TarH; cl00144 114615017212 acetoacetyl-CoA reductase; Region: AcAcCoA_reduct; TIGR01829 114615017213 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 114615017214 NAD(P) binding site [chemical binding]; other site 114615017215 active site 114615017216 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 114615017217 Transcriptional regulator [Transcription]; Region: LysR; COG0583 114615017218 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 114615017219 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 114615017220 putative effector binding pocket; other site 114615017221 dimerization interface [polypeptide binding]; other site 114615017222 hypothetical protein; Provisional; Region: PRK06184 114615017223 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 114615017224 autotransport protein MisL; Provisional; Region: PRK15313 114615017225 Protein of unknown function (DUF1629); Region: DUF1629; pfam07791 114615017226 type I secretion membrane fusion protein, HlyD family; Region: type_I_hlyD; TIGR01843 114615017227 Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the 'double-glycine' leader peptides from the precursors of various bacteriocins (mostly non-lantibiotic). The...; Region: Peptidase_C39_like; cl00296 114615017228 putative active site [active] 114615017229 type I secretion system ABC transporter, HlyB family; Region: type_I_sec_HlyB; TIGR01846 114615017230 ABC transporter transmembrane region; Region: ABC_membrane; cl00549 114615017231 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 114615017232 Walker A/P-loop; other site 114615017233 ATP binding site [chemical binding]; other site 114615017234 Q-loop/lid; other site 114615017235 ABC transporter signature motif; other site 114615017236 Walker B; other site 114615017237 D-loop; other site 114615017238 H-loop/switch region; other site 114615017239 RTX toxin acyltransferase family; Region: HlyC; cl01131 114615017240 putative Helix-turn-helix domain of transposase IS66; Region: HTH_Tnp_IS66; cl14891 114615017241 Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050 114615017242 Protein of unknown function (DUF2924); Region: DUF2924; pfam11149 114615017243 integrase; Provisional; Region: PRK09692 114615017244 Bacteriophage P4 integrase. P4-like integrases are found in temperate bacteriophages, integrative plasmids, pathogenicity and symbiosis islands, and other mobile genetic elements. They share the same fold in their catalytic domain and the overall...; Region: INT_P4; cd00801 114615017245 active site 114615017246 Int/Topo IB signature motif; other site 114615017247 Trehalose-6-Phosphate Synthase (TPS) is a glycosyltransferase that catalyses the synthesis of alpha,alpha-1,1-trehalose-6-phosphate from glucose-6-phosphate using a UDP-glucose donor. It is a key enzyme in the trehalose synthesis pathway. Trehalose is...; Region: GT1_TPS; cd03788 114615017248 active site 114615017249 homotetramer interface [polypeptide binding]; other site 114615017250 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others...; Region: HAD_like; cl11391 114615017251 HAD-superfamily hydrolase, subfamily IIB; Region: HAD-SF-IIB; TIGR01484 114615017252 Sugar (and other) transporter; Region: Sugar_tr; pfam00083 114615017253 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 114615017254 Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices connected by an extended linker. The...; Region: HAMP; cl01054 114615017255 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 114615017256 Taxis toward Aspartate and Related amino acids and Homologs (TarH). The Tar chemoreceptor of Escherichia coli mediates attractant responses to aspartate, maltose, and phenol, repellent responses to Ni2+ and Co2+, and thermoresponses. These...; Region: TarH; cl00144 114615017257 Aerobic-type carbon monoxide dehydrogenase, small subunit CoxS/CutS homologs [Energy production and conversion]; Region: CoxS; COG2080 114615017258 [2Fe-2S] binding domain; Region: Fer2_2; pfam01799 114615017259 Aerobic-type carbon monoxide dehydrogenase, large subunit CoxL/CutL homologs [Energy production and conversion]; Region: CoxL; COG1529 114615017260 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; cl03161 114615017261 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 114615017262 Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM/CutM homologs [Energy production and conversion]; Region: CoxM; COG1319 114615017263 CO dehydrogenase flavoprotein C-terminal domain; Region: CO_deh_flav_C; cl08390 114615017264 CoA-transferase family III; Region: CoA_transf_3; cl00778 114615017265 4-hydroxyphenylpyruvate dioxygenase and related hemolysins [Amino acid transport and metabolism / General function prediction only]; Region: COG3185 114615017266 N-terminal domain of 4-hydroxyphenylpyruvate dioxygenase (HPPD) and hydroxymandelate Synthase (HmaS); Region: HPPD_N_like; cd08342 114615017267 dimer interface [polypeptide binding]; other site 114615017268 C-terminal domain of 4-hydroxyphenylpyruvate dioxygenase (HppD) and hydroxymandelate Synthase (HmaS); Region: HPPD_C_like; cd07250 114615017269 active site 114615017270 Fe binding site [ion binding]; other site 114615017271 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 114615017272 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 114615017273 Protein of unknown function (DUF1272); Region: DUF1272; cl01568 114615017274 fumarylacetoacetase; Region: PLN02856 114615017275 Domain of unknown function (DUF1969); Region: DUF1969; pfam09298 114615017276 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; cl11421 114615017277 homogentisate 1,2-dioxygenase; Region: HgmA; cl10473 114615017278 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 114615017279 Protein of unknown function (DUF2783); Region: DUF2783; pfam10932 114615017280 FAD-dependent oxidoreductase; Provisional; Region: PRK08132 114615017281 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 114615017282 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 114615017283 Transcriptional regulators [Transcription]; Region: MarR; COG1846 114615017284 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 114615017285 Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices connected by an extended linker. The...; Region: HAMP; cl01054 114615017286 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 114615017287 GAF domain; Region: GAF; cl00853 114615017288 cyclase homology domain; Region: CHD; cd07302 114615017289 nucleotidyl binding site; other site 114615017290 metal binding site [ion binding]; metal-binding site 114615017291 dimer interface [polypeptide binding]; other site 114615017292 AsmA family; Region: AsmA; pfam05170 114615017293 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 114615017294 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 114615017295 ligand binding site [chemical binding]; other site 114615017296 flexible hinge region; other site 114615017297 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 114615017298 Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841 114615017299 HlyD family secretion protein; Region: HlyD_2; pfam12700 114615017300 Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2...; Region: Biotinyl_lipoyl_domains; cl11404 114615017301 lipoyl-biotinyl attachment site [posttranslational modification]; other site 114615017302 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 114615017303 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 114615017304 ligand binding site [chemical binding]; other site 114615017305 Caspase, interleukin-1 beta converting enzyme (ICE) homologues; Cysteine-dependent aspartate-directed proteases that mediate programmed cell death (apoptosis). Caspases are synthesized as inactive zymogens and activated by proteolysis of the peptide...; Region: CASc; cl00042 114615017306 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi...; Region: TPR; cd00189 114615017307 binding surface 114615017308 TPR motif; other site 114615017309 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 114615017310 Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376 114615017311 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 114615017312 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 114615017313 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 114615017314 Caspase, interleukin-1 beta converting enzyme (ICE) homologues; Cysteine-dependent aspartate-directed proteases that mediate programmed cell death (apoptosis). Caspases are synthesized as inactive zymogens and activated by proteolysis of the peptide...; Region: CASc; cl00042 114615017315 Staphylococcal nuclease homologues; Region: SNc; smart00318 114615017316 Staphylococcal nuclease homologues. SNase homologues are found in bacteria, archaea, and eukaryotes. They contain no disufide bonds; Region: SNc; cl00140 114615017317 Catalytic site; other site 114615017318 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 114615017319 Serine-pyruvate aminotransferase/archaeal aspartate aminotransferase [Amino acid transport and metabolism]; Region: COG0075 114615017320 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 114615017321 catalytic residue [active] 114615017322 Protease II [Amino acid transport and metabolism]; Region: PtrB; COG1770 114615017323 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 114615017324 Demethylmenaquinone methyltransferase; Region: Methyltransf_6; cl00480 114615017325 dihydroxy-acid dehydratase; Provisional; Region: PRK13017 114615017326 Dehydratase family; Region: ILVD_EDD; cl00340 114615017327 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cl00427 114615017328 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 114615017329 NrtD and SsuB are the ATP-binding subunits of the bacterial ABC-type nitrate and sulfonate transport systems, respectively. ABC transporters are a large family of proteins involved in the transport of a wide variety of different compounds, like sugars...; Region: ABC_NrtD_SsuB_transporters; cd03293 114615017330 Walker A/P-loop; other site 114615017331 ATP binding site [chemical binding]; other site 114615017332 Q-loop/lid; other site 114615017333 ABC transporter signature motif; other site 114615017334 Walker B; other site 114615017335 D-loop; other site 114615017336 H-loop/switch region; other site 114615017337 ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components [Inorganic ion transport and metabolism]; Region: TauA; COG0715 114615017338 Transcriptional regulators [Transcription]; Region: GntR; COG1802 114615017339 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 114615017340 DNA-binding site [nucleotide binding]; DNA binding site 114615017341 FCD domain; Region: FCD; cl11656 114615017342 Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840 114615017343 Taxis toward Aspartate and Related amino acids and Homologs (TarH). The Tar chemoreceptor of Escherichia coli mediates attractant responses to aspartate, maltose, and phenol, repellent responses to Ni2+ and Co2+, and thermoresponses. These...; Region: TarH; cl00144 114615017344 Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840 114615017345 Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices connected by an extended linker. The...; Region: HAMP; cl01054 114615017346 Taxis toward Aspartate and Related amino acids and Homologs (TarH). The Tar chemoreceptor of Escherichia coli mediates attractant responses to aspartate, maltose, and phenol, repellent responses to Ni2+ and Co2+, and thermoresponses. These...; Region: TarH; cl00144 114615017347 Response regulator receiver domain; Region: Response_reg; pfam00072 114615017348 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156 114615017349 active site 114615017350 phosphorylation site [posttranslational modification] 114615017351 intermolecular recognition site; other site 114615017352 dimerization interface [polypeptide binding]; other site 114615017353 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and tungsten-...; Region: Molybdopterin-Binding; cl09928 114615017354 Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices connected by an extended linker. The...; Region: HAMP; cl01054 114615017355 PAS domain S-box; Region: sensory_box; TIGR00229 114615017356 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 114615017357 putative active site [active] 114615017358 heme pocket [chemical binding]; other site 114615017359 PAS domain S-box; Region: sensory_box; TIGR00229 114615017360 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 114615017361 putative active site [active] 114615017362 heme pocket [chemical binding]; other site 114615017363 Signal transduction histidine kinase, nitrogen specific [Signal transduction mechanisms]; Region: NtrB; COG3852 114615017364 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459 114615017365 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via trans-...; Region: HisKA; cd00082 114615017366 dimer interface [polypeptide binding]; other site 114615017367 phosphorylation site [posttranslational modification] 114615017368 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 114615017369 ATP binding site [chemical binding]; other site 114615017370 Mg2+ binding site [ion binding]; other site 114615017371 G-X-G motif; other site 114615017372 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 114615017373 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156 114615017374 active site 114615017375 phosphorylation site [posttranslational modification] 114615017376 intermolecular recognition site; other site 114615017377 dimerization interface [polypeptide binding]; other site 114615017378 response regulator FixJ; Provisional; Region: fixJ; PRK09390 114615017379 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156 114615017380 active site 114615017381 phosphorylation site [posttranslational modification] 114615017382 intermolecular recognition site; other site 114615017383 dimerization interface [polypeptide binding]; other site 114615017384 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors...; Region: LuxR_C_like; cd06170 114615017385 DNA binding residues [nucleotide binding] 114615017386 dimerization interface [polypeptide binding]; other site 114615017387 Response regulator receiver domain; Region: Response_reg; pfam00072 114615017388 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156 114615017389 active site 114615017390 phosphorylation site [posttranslational modification] 114615017391 intermolecular recognition site; other site 114615017392 Methyltransferase, chemotaxis proteins; Region: MeTrc; smart00138 114615017393 CheR methyltransferase, all-alpha domain; Region: CheR_N; pfam03705 114615017394 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cl12011 114615017395 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156 114615017396 Response regulator receiver domain; Region: Response_reg; pfam00072 114615017397 active site 114615017398 phosphorylation site [posttranslational modification] 114615017399 intermolecular recognition site; other site 114615017400 dimerization interface [polypeptide binding]; other site 114615017401 CheW, a small regulator protein, unique to the chemotaxis signalling in prokaryotes and archea. CheW interacts with the histidine kinase CheA, most likely with the related regulatory domain of CheA. CheW is proposed to form signalling arrays together...; Region: CheW; cd00732 114615017402 putative CheA interaction surface; other site 114615017403 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 114615017404 putative binding surface; other site 114615017405 active site 114615017406 Signal transducing histidine kinase, homodimeric domain; Region: H-kinase_dim; pfam02895 114615017407 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 114615017408 ATP binding site [chemical binding]; other site 114615017409 Mg2+ binding site [ion binding]; other site 114615017410 G-X-G motif; other site 114615017411 CheA regulatory domain; CheA is a histidine protein kinase present in bacteria and archea. Activated by the chemotaxis receptor a histidine phosphoryl group from CheA is passed directly to an aspartate in the response regulator CheY. This signalling...; Region: CheA_reg; cd00731 114615017412 CheW-like domain. CheW proteins are part of the chemotaxis signalling mechanism in bacteria. CheW interacts with the methyl accepting chemotaxis proteins (MCPs) and relays signals to CheY, which affects flageller rotation. This family includes CheW and...; Region: CheW_like; cl00256 114615017413 Response regulator receiver domain; Region: Response_reg; pfam00072 114615017414 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156 114615017415 active site 114615017416 phosphorylation site [posttranslational modification] 114615017417 intermolecular recognition site; other site 114615017418 dimerization interface [polypeptide binding]; other site 114615017419 Flagellar protein FlbT; Region: FlbT; cl11455 114615017420 flagellin; Reviewed; Region: PRK12688 114615017421 flagellin; Reviewed; Region: PRK12688 114615017422 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via trans-...; Region: HisKA; cd00082 114615017423 histidine kinase; Provisional; Region: PRK13557 114615017424 dimer interface [polypeptide binding]; other site 114615017425 phosphorylation site [posttranslational modification] 114615017426 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 114615017427 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 114615017428 ligand binding site [chemical binding]; other site 114615017429 flexible hinge region; other site 114615017430 Response regulator receiver domain; Region: Response_reg; pfam00072 114615017431 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156 114615017432 active site 114615017433 phosphorylation site [posttranslational modification] 114615017434 intermolecular recognition site; other site 114615017435 dimerization interface [polypeptide binding]; other site 114615017436 Response regulator receiver domain; Region: Response_reg; pfam00072 114615017437 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156 114615017438 active site 114615017439 phosphorylation site [posttranslational modification] 114615017440 intermolecular recognition site; other site 114615017441 dimerization interface [polypeptide binding]; other site 114615017442 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via trans-...; Region: HisKA; cd00082 114615017443 dimer interface [polypeptide binding]; other site 114615017444 phosphorylation site [posttranslational modification] 114615017445 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 114615017446 ATP binding site [chemical binding]; other site 114615017447 Mg2+ binding site [ion binding]; other site 114615017448 G-X-G motif; other site 114615017449 Response regulator receiver domain; Region: Response_reg; pfam00072 114615017450 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156 114615017451 active site 114615017452 phosphorylation site [posttranslational modification] 114615017453 intermolecular recognition site; other site 114615017454 dimerization interface [polypeptide binding]; other site 114615017455 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cl00086 114615017456 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors...; Region: LuxR_C_like; cd06170 114615017457 DNA binding residues [nucleotide binding] 114615017458 dimerization interface [polypeptide binding]; other site 114615017459 indolepyruvate/phenylpyruvate decarboxylase, Azospirillum family; Region: indol_phenyl_DC; TIGR03394 114615017460 Pyrimidine (PYR) binding domain of thiamine pyrophosphate (TPP)-dependent enzymes; Region: TPP_enzyme_PYR; cl11410 114615017461 PYR/PP interface [polypeptide binding]; other site 114615017462 dimer interface [polypeptide binding]; other site 114615017463 TPP binding site [chemical binding]; other site 114615017464 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 114615017465 Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin...; Region: TPP_enzymes; cl01629 114615017466 TPP-binding site [chemical binding]; other site 114615017467 lipoxygenase; Region: PLN02337 114615017468 Transglutaminase-like superfamily; Region: Transglut_core; cl10469 114615017469 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 114615017470 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following...; Region: ParA; cd02042 114615017471 P-loop; other site 114615017472 Magnesium ion binding site [ion binding]; other site 114615017473 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 114615017474 This family is most closely related to the GT1 family of glycosyltransferases. ExpC in Rhizobium meliloti has been shown to be involved in the biosynthesis of galactoglucan (exopolysaccharide II); Region: GT1_ExpC_like; cd03818 114615017475 putative ADP-binding pocket [chemical binding]; other site 114615017476 Subfamily of Glycosyltransferase Family GT2 of unknown function; Region: GT_2_like_c; cd04186 114615017477 Probable Catalytic site [active] 114615017478 metal binding site [ion binding]; metal-binding site 114615017479 Subfamily of Glycosyltransferase Family GT2 of unknown function; Region: GT_2_like_c; cd04186 114615017480 Probable Catalytic site [active] 114615017481 metal binding site [ion binding]; metal-binding site 114615017482 dTDP-6-deoxy-L-lyxo-4-hexulose reductase and related proteins, extended (e) SDRs; Region: dTDP_HR_like_SDR_e; cd05254 114615017483 RmlD substrate binding domain; Region: RmlD_sub_bind; pfam04321 114615017484 NADP binding site [chemical binding]; other site 114615017485 active site 114615017486 putative substrate binding site [chemical binding]; other site 114615017487 Cupin domain; Region: Cupin_2; cl09118 114615017488 G1P_TT_short is the short form of glucose-1-phosphate thymidylyltransferase; Region: G1P_TT_short; cd02538 114615017489 glucose-1-phosphate thymidylyltransferase, short form; Region: rmlA; TIGR01207 114615017490 substrate binding site [chemical binding]; other site 114615017491 tetramer interface [polypeptide binding]; other site 114615017492 dTDP-D-glucose 4,6-dehydratase, extended (e) SDRs; Region: dTDP_GD_SDR_e; cd05246 114615017493 dTDP-glucose 4,6 dehydratase; Provisional; Region: PRK10084 114615017494 NAD binding site [chemical binding]; other site 114615017495 substrate binding site [chemical binding]; other site 114615017496 homodimer interface [polypeptide binding]; other site 114615017497 active site 114615017498 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 114615017499 active site 114615017500 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 114615017501 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 114615017502 FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790 114615017503 Sel1 repeat; Region: Sel1; cl02723 114615017504 FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790 114615017505 Sel1 repeat; Region: Sel1; cl02723 114615017506 Sel1 repeat; Region: Sel1; cl02723 114615017507 Sel1 repeat; Region: Sel1; cl02723 114615017508 FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790 114615017509 Sel1 repeat; Region: Sel1; cl02723 114615017510 Sel1 repeat; Region: Sel1; cl02723 114615017511 Sel1 repeat; Region: Sel1; cl02723 114615017512 Sel1 repeat; Region: Sel1; cl02723 114615017513 type I secretion membrane fusion protein, HlyD family; Region: type_I_hlyD; TIGR01843 114615017514 ABC-type bacteriocin/lantibiotic exporters, contain an N-terminal double-glycine peptidase domain [Defense mechanisms]; Region: SunT; COG2274 114615017515 Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the 'double-glycine' leader peptides from the precursors of various bacteriocins (mostly non-lantibiotic). The...; Region: Peptidase_C39_like; cl00296 114615017516 putative active site [active] 114615017517 ABC transporter transmembrane region; Region: ABC_membrane; cl00549 114615017518 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 114615017519 Walker A/P-loop; other site 114615017520 ATP binding site [chemical binding]; other site 114615017521 Q-loop/lid; other site 114615017522 ABC transporter signature motif; other site 114615017523 Walker B; other site 114615017524 D-loop; other site 114615017525 H-loop/switch region; other site 114615017526 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cl12011 114615017527 Peptidase M10 serralysin C terminal; Region: Peptidase_M10_C; pfam08548 114615017528 Peptidase M10 serralysin C terminal; Region: Peptidase_M10_C; pfam08548 114615017529 Peptidase M10 serralysin C terminal; Region: Peptidase_M10_C; pfam08548 114615017530 Peptidase M10 serralysin C terminal; Region: Peptidase_M10_C; pfam08548 114615017531 Peptidase M10 serralysin C terminal; Region: Peptidase_M10_C; pfam08548 114615017532 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 114615017533 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 114615017534 Alginate Lyase A1-III; enzymatically depolymerizes alginate, a complex copolymer of beta-D-mannuronate and alpha-L-guluronate, by cleaving the beta-(1,4) glycosidic bond; Region: AlgLyase; cl00179 114615017535 Heparinase II/III-like protein; Region: Hepar_II_III; pfam07940 114615017536 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 114615017537 2-desacetyl-2-hydroxyethyl bacteriochlorophyllide and other MDR family members; Region: 2-desacetyl-2-hydroxyethyl_bacteriochlorophyllide_; cd08255 114615017538 putative NAD(P) binding site [chemical binding]; other site 114615017539 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 114615017540 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 114615017541 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; cl11611 114615017542 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 114615017543 This family is most closely related to the GT1 family of glycosyltransferases. wbuB in E. coli is involved in the biosynthesis of the O26 O-antigen. It has been proposed to function as an N-acetyl-L-fucosamine (L-FucNAc) transferase; Region: GT1_wbuB_like; cd03794 114615017544 nucleotide sugar dehydrogenase; Region: NDP-sugDHase; TIGR03026 114615017545 UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984 114615017546 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 114615017547 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cd02440 114615017548 S-adenosylmethionine binding site [chemical binding]; other site 114615017549 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cl12011 114615017550 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cl12011 114615017551 Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244 114615017552 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 114615017553 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cl12011 114615017554 Chain length determinant protein; Region: Wzz; cl01623 114615017555 exopolysaccharide transport protein family; Region: eps_transp_fam; TIGR01005 114615017556 Syntaxin N-terminus domain; syntaxins are nervous system-specific proteins implicated in the docking of synaptic vesicles with the presynaptic plasma membrane; they are a family of receptors for intracellular transport vesicles; each target membrane...; Region: SynN; cl00143 114615017557 interdomain interaction site; other site 114615017558 nSec1 interaction sites; other site 114615017559 O-Antigen ligase; Region: Wzy_C; cl04850 114615017560 Periplasmic protein involved in polysaccharide export, contains SLBB domain of b-grasp fold [Cell wall/membrane/envelope biogenesis]; Region: Wza; COG1596 114615017561 Polysaccharide biosynthesis/export protein; Region: Poly_export; pfam02563 114615017562 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 114615017563 phosphoprotein phosphatases of the metallophosphatase superfamily, metallophosphatase domain; Region: MPP_PPP_family; cd00144 114615017564 active site 114615017565 metal binding site [ion binding]; metal-binding site 114615017566 Undecaprenyl-phosphate glucose phosphotransferase; Region: WcaJ_sugtrans; TIGR03023 114615017567 Bacterial sugar transferase; Region: Bac_transf; cl00939 114615017568 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 114615017569 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 114615017570 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 114615017571 This family is most closely related to the GT1 family of glycosyltransferases. wlbH in Bordetella parapertussis has been shown to be required for the biosynthesis of a trisaccharide that, when attached to the B. pertussis lipopolysaccharide (LPS) core (; Region: GT1_wlbH_like; cd03798 114615017572 Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726 114615017573 Polysaccharide deacetylase; Region: Polysacc_deac_1; cl12061 114615017574 Polysaccharide deacetylase; Region: Polysacc_deac_1; cl12061 114615017575 Uncharacterized membrane protein, putative virulence factor [General function prediction only]; Region: MviN; COG0728 114615017576 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 114615017577 Chain length determinant protein; Region: Wzz; cl01623 114615017578 Uncharacterized protein involved in exopolysaccharide biosynthesis [Cell envelope biogenesis, outer membrane]; Region: GumC; COG3206 114615017579 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Mrp; COG0489 114615017580 Ras-like GTPase superfamily. The Ras-like superfamily of small GTPases consists of several families with an extremely high degree of structural and functional similarity. The Ras superfamily is divided into at least four families in eukaryotes: the Ras...; Region: Ras_like_GTPase; cl10444 114615017581 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 114615017582 This family is most closely related to the GT1 family of glycosyltransferases. wbaZ in Salmonella enterica has been shown to possess the mannosyl transferase activity. The members of this family are found in certain bacteria and Archaea; Region: GT1_wbaZ_like; cd03804 114615017583 putative ADP-binding pocket [chemical binding]; other site 114615017584 Protein of unknown function (DUF2848); Region: DUF2848; pfam11010 114615017585 Protein of unknown function (DUF3422); Region: DUF3422; cl02073 114615017586 Uncharacterized conserved protein [Function unknown]; Region: COG3586 114615017587 Phd_YefM; Region: PhdYeFM; cl09153 114615017588 PIN domain of ribonucleases (toxins), VapC and FitB, of prokaryotic toxin/antitoxin operons, Pyrococcus horikoshii protein PH0500, and other similar bacterial and archaeal homologs; Region: PIN_VapC-FitB; cd09881 114615017589 oligomeric interface; other site 114615017590 putative active site [active] 114615017591 homodimer interface [polypeptide binding]; other site 114615017592 Glucose/sorbosone dehydrogenases [Carbohydrate transport and metabolism]; Region: COG2133 114615017593 Membrane bound L-sorbosone dehydrogenase; Region: SNDH; pfam12303 114615017594 NAD-dependent deacetylase; Provisional; Region: PRK05333 114615017595 SIRT4: Eukaryotic and prokaryotic group (class2) which includes human sirtuin SIRT4 and several bacterial homologs; and are members of the SIR2 family of proteins, silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein/...; Region: SIRT4; cd01409 114615017596 NAD+ binding site [chemical binding]; other site 114615017597 substrate binding site [chemical binding]; other site 114615017598 Zn binding site [ion binding]; other site 114615017599 putative urate catabolism protein; Region: uraD_N-term-dom; TIGR03212 114615017600 Polysaccharide deacetylase; Region: Polysacc_deac_1; cl12061 114615017601 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261 114615017602 dimer interface [polypeptide binding]; other site 114615017603 conserved gate region; other site 114615017604 putative PBP binding loops; other site 114615017605 ABC-ATPase subunit interface; other site 114615017606 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261 114615017607 dimer interface [polypeptide binding]; other site 114615017608 conserved gate region; other site 114615017609 putative PBP binding loops; other site 114615017610 ABC-ATPase subunit interface; other site 114615017611 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 114615017612 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 114615017613 Walker A/P-loop; other site 114615017614 ATP binding site [chemical binding]; other site 114615017615 Q-loop/lid; other site 114615017616 ABC transporter signature motif; other site 114615017617 Walker B; other site 114615017618 D-loop; other site 114615017619 H-loop/switch region; other site 114615017620 TOBE domain; Region: TOBE_2; cl01440 114615017621 Spermidine/putrescine-binding periplasmic protein [Amino acid transport and metabolism]; Region: PotD; COG0687 114615017622 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 114615017623 Transcriptional regulators [Transcription]; Region: GntR; COG1802 114615017624 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 114615017625 DNA-binding site [nucleotide binding]; DNA binding site 114615017626 FCD domain; Region: FCD; cl11656 114615017627 cyclase homology domain; Region: CHD; cd07302 114615017628 nucleotidyl binding site; other site 114615017629 metal binding site [ion binding]; metal-binding site 114615017630 dimer interface [polypeptide binding]; other site 114615017631 Predicted integral membrane protein (DUF2282); Region: DUF2282; cl02366 114615017632 Protein of unknown function (DUF692); Region: DUF692; cl01263 114615017633 hypothetical protein; Provisional; Region: PRK05409 114615017634 Uncharacterized protein conserved in bacteria (DUF2063); Region: DUF2063; cl01262 114615017635 DoxX; Region: DoxX; cl00976 114615017636 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cd02440 114615017637 S-adenosylmethionine binding site [chemical binding]; other site 114615017638 DPM_DPG-synthase_like is a member of the Glycosyltransferase 2 superfamily; Region: DPM_DPG-synthase_like; cd04179 114615017639 Ligand binding site [chemical binding]; other site 114615017640 Putative Catalytic site [active] 114615017641 DXD motif; other site 114615017642 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3012 114615017643 SEC-C motif; Region: SEC-C; cl12132 114615017644 SEC-C motif; Region: SEC-C; cl12132 114615017645 Protein of unknown function (DUF419); Region: DUF419; cl15265 114615017646 Carboxymuconolactone decarboxylase family; Region: CMD; cl00460 114615017647 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 114615017648 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 114615017649 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl15258 114615017650 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 114615017651 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 114615017652 active site 114615017653 aliphatic amidases (class 2 nitrilases); Region: aliphatic_amidase; cd07565 114615017654 Predicted amidohydrolase [General function prediction only]; Region: COG0388 114615017655 multimer interface [polypeptide binding]; other site 114615017656 active site 114615017657 catalytic triad [active] 114615017658 dimer interface [polypeptide binding]; other site 114615017659 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 114615017660 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 114615017661 Protein of unknown function (DUF1348); Region: DUF1348; pfam07080 114615017662 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109 114615017663 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via trans-...; Region: HisKA; cd00082 114615017664 dimer interface [polypeptide binding]; other site 114615017665 phosphorylation site [posttranslational modification] 114615017666 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 114615017667 ATP binding site [chemical binding]; other site 114615017668 Mg2+ binding site [ion binding]; other site 114615017669 G-X-G motif; other site 114615017670 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 114615017671 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156 114615017672 active site 114615017673 phosphorylation site [posttranslational modification] 114615017674 intermolecular recognition site; other site 114615017675 dimerization interface [polypeptide binding]; other site 114615017676 Surface antigen; Region: Surface_Ag_2; cl01155 114615017677 ABC-2 type transporter; Region: ABC2_membrane; cl11417 114615017678 ATPase components of various ABC-type transport systems, contain duplicated ATPase [General function prediction only]; Region: COG1123 114615017679 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 114615017680 Walker A/P-loop; other site 114615017681 ATP binding site [chemical binding]; other site 114615017682 Q-loop/lid; other site 114615017683 ABC transporter signature motif; other site 114615017684 Walker B; other site 114615017685 D-loop; other site 114615017686 H-loop/switch region; other site 114615017687 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 114615017688 Walker A/P-loop; other site 114615017689 ATP binding site [chemical binding]; other site 114615017690 Q-loop/lid; other site 114615017691 ABC transporter signature motif; other site 114615017692 Walker B; other site 114615017693 D-loop; other site 114615017694 H-loop/switch region; other site 114615017695 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 114615017696 ABC-2 type transporter; Region: ABC2_membrane; cl11417 114615017697 putative efflux pump membrane fusion protein; Provisional; Region: PRK03598 114615017698 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi...; Region: TPR; cd00189 114615017699 TPR motif; other site 114615017700 binding surface 114615017701 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi...; Region: TPR; cd00189 114615017702 TPR motif; other site 114615017703 binding surface 114615017704 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi...; Region: TPR; cd00189 114615017705 binding surface 114615017706 TPR motif; other site 114615017707 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi...; Region: TPR; cd00189 114615017708 binding surface 114615017709 TPR motif; other site 114615017710 Anaphase-promoting complex, cyclosome, subunit 3; Region: Apc3; pfam12895 114615017711 Undecaprenyl pyrophosphate synthase [Lipid metabolism]; Region: UppS; COG0020 114615017712 Cis (Z)-Isoprenyl Diphosphate Synthases (cis-IPPS); homodimers which catalyze the successive 1'-4 condensation of the isopentenyl diphosphate (IPP) molecule to trans,trans-farnesyl diphosphate (FPP) or to cis,trans-FPP to form long-chain polyprenyl...; Region: CIS_IPPS; cl00230 114615017713 catalytic residue [active] 114615017714 putative FPP diphosphate binding site; other site 114615017715 putative FPP binding hydrophobic cleft; other site 114615017716 dimer interface [polypeptide binding]; other site 114615017717 putative IPP diphosphate binding site; other site 114615017718 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 114615017719 Hypothetical protein (DUF2513); Region: DUF2513; pfam10711 114615017720 Protein of unknown function (DUF3551); Region: DUF3551; pfam12071 114615017721 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3181 114615017722 Tripartite tricarboxylate transporter family receptor; Region: TctC; cl15260 114615017723 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_2; cd07253 114615017724 dimer interface [polypeptide binding]; other site 114615017725 metal binding site [ion binding]; metal-binding site 114615017726 Uncharacterized protein conserved in bacteria (DUF2330); Region: DUF2330; cl01827 114615017727 Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318 114615017728 Acyl-protein synthetase, LuxE; Region: LuxE; cl10450 114615017729 Cytochrome P450; Region: p450; cl12078 114615017730 Cytochrome P450; Region: p450; cl12078 114615017731 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cl09944 114615017732 active site 114615017733 phosphorylation site [posttranslational modification] 114615017734 dimerization interface [polypeptide binding]; other site 114615017735 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 114615017736 Zn2+ binding site [ion binding]; other site 114615017737 Mg2+ binding site [ion binding]; other site 114615017738 Aerobic-type carbon monoxide dehydrogenase, large subunit CoxL/CutL homologs [Energy production and conversion]; Region: CoxL; COG1529 114615017739 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 114615017740 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; cl03161 114615017741 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 114615017742 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 114615017743 Aerobic-type carbon monoxide dehydrogenase, small subunit CoxS/CutS homologs [Energy production and conversion]; Region: CoxS; COG2080 114615017744 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cl00159 114615017745 [2Fe-2S] binding domain; Region: Fer2_2; pfam01799 114615017746 Dienelactone hydrolase family; Region: DLH; pfam01738 114615017747 Polysaccharide biosynthesis/export protein; Region: Poly_export; pfam02563 114615017748 putative polysaccharide export protein, PEP-CTERM sytem-associated; Region: pepcterm_export; TIGR03027 114615017749 SLBB domain; Region: SLBB; pfam10531 114615017750 Peptide methionine sulfoxide reductase; Region: PMSR; cl00366 114615017751 Ribosomal protein S20; Region: Ribosomal_S20p; cl00384