-- dump date 20140619_005817 -- class Genbank::misc_feature -- table misc_feature_note -- id note 114615000001 DnaA N-terminal domain; Region: DnaA_N; pfam11638 114615000002 chromosomal replication initiator protein DnaA; Region: DnaA; TIGR00362 114615000003 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 114615000004 Walker A motif; other site 114615000005 ATP binding site [chemical binding]; other site 114615000006 Walker B motif; other site 114615000007 arginine finger; other site 114615000008 C-terminal domain of bacterial DnaA proteins. The DNA-binding C-terminal domain of DnaA contains a helix-turn-helix motif that specifically interacts with the DnaA box, a 9-mer motif that occurs repetitively in the replication origin oriC. Multiple...; Region: Bac_DnaA_C; cd06571 114615000009 DnaA box-binding interface [nucleotide binding]; other site 114615000010 DNA polymerase III subunit beta; Validated; Region: PRK05643 114615000011 Beta clamp domain. The beta subunit (processivity factor) of DNA polymerase III holoenzyme, refered to as the beta clamp, forms a ring shaped dimer that encircles dsDNA (sliding clamp) in bacteria. The beta-clamp is structurally similar to the trimeric...; Region: beta_clamp; cd00140 114615000012 putative DNA binding surface [nucleotide binding]; other site 114615000013 dimer interface [polypeptide binding]; other site 114615000014 beta-clamp/clamp loader binding surface; other site 114615000015 beta-clamp/translesion DNA polymerase binding surface; other site 114615000016 recombination protein F; Reviewed; Region: recF; PRK00064 114615000017 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 114615000018 Walker A/P-loop; other site 114615000019 ATP binding site [chemical binding]; other site 114615000020 Q-loop/lid; other site 114615000021 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 114615000022 ABC transporter signature motif; other site 114615000023 Walker B; other site 114615000024 D-loop; other site 114615000025 H-loop/switch region; other site 114615000026 DNA gyrase subunit B; Provisional; Region: gyrB; PRK14939 114615000027 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 114615000028 Mg2+ binding site [ion binding]; other site 114615000029 G-X-G motif; other site 114615000030 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822 114615000031 anchoring element; other site 114615000032 dimer interface [polypeptide binding]; other site 114615000033 ATP binding site [chemical binding]; other site 114615000034 TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of the...; Region: TOPRIM_TopoIIA_GyrB; cd03366 114615000035 active site 114615000036 putative metal-binding site [ion binding]; other site 114615000037 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 114615000038 UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Region: murA; TIGR01072 114615000039 UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555 114615000040 hinge; other site 114615000041 active site 114615000042 Protein of unknown function (DUF2867); Region: DUF2867; pfam11066 114615000043 Sterol desaturase [Lipid metabolism]; Region: ERG3; COG3000 114615000044 Fatty acid hydroxylase superfamily; Region: FA_hydroxylase; pfam04116 114615000045 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 114615000046 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 114615000047 DNA binding residues [nucleotide binding] 114615000048 dimerization interface [polypeptide binding]; other site 114615000049 Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Vibrio cholerae NorM; Region: MATE_NorM_like; cd13131 114615000050 multidrug efflux protein; Reviewed; Region: PRK01766 114615000051 cation binding site [ion binding]; other site 114615000052 Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515 114615000053 MmgE/PrpD family; Region: MmgE_PrpD; cl00912 114615000054 Beta-lactamase; Region: Beta-lactamase; pfam00144 114615000055 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 114615000056 Helix-turn-helix domain; Region: HTH_18; pfam12833 114615000057 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 114615000058 Pirin-related protein [General function prediction only]; Region: COG1741 114615000059 Pirin; Region: Pirin; pfam02678 114615000060 Pirin C-terminal cupin domain; Region: Pirin_C; pfam05726 114615000061 non-metazoan 5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide (SAICAR) synthase; Region: SAICAR_synt_Sc; cd01414 114615000062 ATP binding site [chemical binding]; other site 114615000063 active site 114615000064 substrate binding site [chemical binding]; other site 114615000065 LysR family transcriptional regulator; Provisional; Region: PRK14997 114615000066 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 114615000067 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 114615000068 putative effector binding pocket; other site 114615000069 dimerization interface [polypeptide binding]; other site 114615000070 short chain dehydrogenase; Provisional; Region: PRK06500 114615000071 classical (c) SDRs; Region: SDR_c; cd05233 114615000072 NAD(P) binding site [chemical binding]; other site 114615000073 active site 114615000074 SnoaL-like domain; Region: SnoaL_2; pfam12680 114615000075 Nitroreductase family. Members of this family utilize FMN as a cofactor and catalyze reduction of a variety of nitroaromatic compounds, including nitrofurans, nitrobenzens, nitrophenol, nitrobenzoate and quinones by using either NADH or NADPH as a source...; Region: Nitroreductase; cd02136 114615000076 putative FMN binding site [chemical binding]; other site 114615000077 Predicted phosphatases [General function prediction only]; Region: Gph; COG0546 114615000078 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 114615000079 motif II; other site 114615000080 ornithine carbamoyltransferase; Region: orni_carb_tr; TIGR00658 114615000081 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 114615000082 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 114615000083 L-alanine-DL-glutamate epimerase and related enzymes of enolase superfamily [Cell envelope biogenesis, outer membrane / General function prediction only]; Region: COG4948 114615000084 Mandelate racemase (MR)-like subfamily of the enolase superfamily. Enzymes of this subgroup share three conserved carboxylate ligands for the essential divalent metal ion (usually Mg2+), two aspartates and a glutamate, and conserved catalytic residues; Region: MR_like; cd03316 114615000085 active site pocket [active] 114615000086 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 114615000087 GST_N family, Saccharomyces cerevisiae GTT2-like subfamily; composed of predominantly uncharacterized proteins with similarity to the S. cerevisiae GST protein, GTT2. GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing...; Region: GST_N_GTT2_like; cd03051 114615000088 putative C-terminal domain interface [polypeptide binding]; other site 114615000089 putative GSH binding site (G-site) [chemical binding]; other site 114615000090 putative dimer interface [polypeptide binding]; other site 114615000091 C-terminal, alpha helical domain of the Glutathione S-transferase family; Region: GST_C_family; cl02776 114615000092 N-terminal domain interface [polypeptide binding]; other site 114615000093 dimer interface [polypeptide binding]; other site 114615000094 substrate binding pocket (H-site) [chemical binding]; other site 114615000095 Phytanoyl-CoA dioxygenase (PhyH); Region: PhyH; pfam05721 114615000096 Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659 114615000097 Sulfate transporter family; Region: Sulfate_transp; pfam00916 114615000098 Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function; Region: STAS_SulP_like_sulfate_transporter; cd07042 114615000099 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 114615000100 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 114615000101 ligand binding site [chemical binding]; other site 114615000102 flexible hinge region; other site 114615000103 succinic semialdehyde dehydrogenase; Region: PLN02278 114615000104 Mitochondrial succinate-semialdehyde dehydrogenase and ALDH family members 5A1 and 5F1-like; Region: ALDH_F5_SSADH_GabD; cd07103 114615000105 tetramerization interface [polypeptide binding]; other site 114615000106 NAD(P) binding site [chemical binding]; other site 114615000107 catalytic residues [active] 114615000108 Beta-lactamase; Region: Beta-lactamase; pfam00144 114615000109 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 114615000110 Adenosine kinase (AK) catalyzes the phosphorylation of ribofuranosyl-containing nucleoside analogues at the 5'-hydroxyl using ATP or GTP as the phosphate donor.The physiological function of AK is associated with the regulation of extracellular...; Region: adenosine_kinase; cd01168 114615000111 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 114615000112 substrate binding site [chemical binding]; other site 114615000113 ATP binding site [chemical binding]; other site 114615000114 Uncharacterized membrane protein, putative virulence factor [General function prediction only]; Region: MviN; COG0728 114615000115 MurJ/MviN, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_MurJ_like; cd13123 114615000116 tryptophanyl-tRNA synthetase II; Reviewed; Region: PRK12282 114615000117 catalytic core domain of tryptophanyl-tRNA synthetase; Region: TrpRS_core; cd00806 114615000118 active site 114615000119 HIGH motif; other site 114615000120 dimer interface [polypeptide binding]; other site 114615000121 KMSKS motif; other site 114615000122 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 114615000123 Ligand Binding Site [chemical binding]; other site 114615000124 Scaffold protein Nfu/NifU N terminal; Region: Nfu_N; pfam08712 114615000125 Thioredoxin-like proteins and domains [Posttranslational modification, protein turnover, chaperones]; Region: COG0694 114615000126 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 114615000127 FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202 114615000128 putative active site [active] 114615000129 heme pocket [chemical binding]; other site 114615000130 FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202 114615000131 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 114615000132 putative active site [active] 114615000133 heme pocket [chemical binding]; other site 114615000134 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 114615000135 putative active site [active] 114615000136 heme pocket [chemical binding]; other site 114615000137 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 114615000138 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 114615000139 dimer interface [polypeptide binding]; other site 114615000140 putative CheW interface [polypeptide binding]; other site 114615000141 tRNA threonylcarbamoyl adenosine modification protein YeaZ; Region: T6A_YeaZ; TIGR03725 114615000142 Glycoprotease family; Region: Peptidase_M22; pfam00814 114615000143 ribosomal-protein-alanine acetyltransferase; Region: rimI; TIGR01575 114615000144 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 114615000145 Coenzyme A binding pocket [chemical binding]; other site 114615000146 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 114615000147 metal binding site 2 [ion binding]; metal-binding site 114615000148 putative DNA binding helix; other site 114615000149 metal binding site 1 [ion binding]; metal-binding site 114615000150 dimer interface [polypeptide binding]; other site 114615000151 structural Zn2+ binding site [ion binding]; other site 114615000152 Predicted phosphatase/phosphohexomutase [General function prediction only]; Region: COG0637 114615000153 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 114615000154 motif II; other site 114615000155 (dimethylallyl)adenosine tRNA methylthiotransferase; Provisional; Region: PRK14325 114615000156 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 114615000157 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 114615000158 FeS/SAM binding site; other site 114615000159 TRAM domain; Region: TRAM; cl01282 114615000160 Phosphate starvation-inducible protein PhoH, predicted ATPase [Signal transduction mechanisms]; Region: PhoH; COG1702 114615000161 PhoH-like protein; Region: PhoH; pfam02562 114615000162 Predicted metal-dependent hydrolase [General function prediction only]; Region: COG0319 114615000163 Putative Mg2+ and Co2+ transporter CorC [Inorganic ion transport and metabolism]; Region: CorC; COG4535 114615000164 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 114615000165 Transporter associated domain; Region: CorC_HlyC; pfam03471 114615000166 apolipoprotein N-acyltransferase; Reviewed; Region: lnt; PRK00302 114615000167 Apolipoprotein N-acyl transferase (class 9 nitrilases); Region: ALP_N-acyl_transferase; cd07571 114615000168 putative active site [active] 114615000169 catalytic triad [active] 114615000170 putative dimer interface [polypeptide binding]; other site 114615000171 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 114615000172 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 114615000173 non-specific DNA binding site [nucleotide binding]; other site 114615000174 salt bridge; other site 114615000175 sequence-specific DNA binding site [nucleotide binding]; other site 114615000176 hypothetical protein; Provisional; Region: PRK07338 114615000177 M20 Peptidase Glutamate carboxypeptidase, a periplasmic enzyme; Region: M20_CPDG2; cd03885 114615000178 metal binding site [ion binding]; metal-binding site 114615000179 dimer interface [polypeptide binding]; other site 114615000180 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 114615000181 S-adenosylmethionine binding site [chemical binding]; other site 114615000182 Uncharacterized protein conserved in bacteria (DUF2336); Region: DUF2336; pfam10098 114615000183 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG0779 114615000184 Sm and related proteins; Region: Sm_like; cl00259 114615000185 Bacillus subtilis YxlS-like, C-terminal domain; Region: YlxS_C; cd01734 114615000186 putative oligomer interface [polypeptide binding]; other site 114615000187 putative RNA binding site [nucleotide binding]; other site 114615000188 transcription elongation factor NusA; Validated; Region: nusA; PRK09202 114615000189 NusA N-terminal domain; Region: NusA_N; pfam08529 114615000190 S1_NusA: N-utilizing substance A protein (NusA), S1-like RNA-binding domain. S1-like RNA-binding domains are found in a wide variety of RNA-associated proteins. NusA is a transcription elongation factor containing an N-terminal catalytic domain and three...; Region: S1_NusA; cd04455 114615000191 RNA binding site [nucleotide binding]; other site 114615000192 homodimer interface [polypeptide binding]; other site 114615000193 NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134 114615000194 G-X-X-G motif; other site 114615000195 NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134 114615000196 G-X-X-G motif; other site 114615000197 transcription termination factor NusA, C-terminal duplication; Region: nusA_Cterm_rpt; TIGR01954 114615000198 hypothetical protein; Provisional; Region: PRK09190 114615000199 Ylxr homologs; group of conserved hypothetical bacterial proteins of unknown function; structure revealed putative RNA binding cleft; proteins are encoded by an operon that includes other proteins involved in transcription and/or translation; Region: YlxR; cd00279 114615000200 putative RNA binding cleft [nucleotide binding]; other site 114615000201 Bacterial translation initiation factor IF-2 associated region; Region: IF2_assoc; pfam08364 114615000202 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 114615000203 Translation initiation factor 2 (IF-2; GTPase) [Translation, ribosomal structure and biogenesis]; Region: InfB; COG0532 114615000204 Initiation Factor 2 (IF2)/ eukaryotic Initiation Factor 5B (eIF5B) family; Region: IF2_eIF5B; cd01887 114615000205 G1 box; other site 114615000206 putative GEF interaction site [polypeptide binding]; other site 114615000207 GTP/Mg2+ binding site [chemical binding]; other site 114615000208 Switch I region; other site 114615000209 G2 box; other site 114615000210 G3 box; other site 114615000211 Switch II region; other site 114615000212 G4 box; other site 114615000213 G5 box; other site 114615000214 This family represents the domain II of bacterial Initiation Factor 2 (IF2) and its eukaryotic mitochondrial homologue mtIF2. IF2, the largest initiation factor is an essential GTP binding protein. In E. coli three natural forms of IF2 exist in the cell; Region: IF2_mtIF2_II; cd03702 114615000215 Translation-initiation factor 2; Region: IF-2; pfam11987 114615000216 mtIF2_IVc: this family represents the C2 subdomain of domain IV of mitochondrial translation initiation factor 2 (mtIF2) which adopts a beta-barrel fold displaying a high degree of structural similarity with domain II of the translation elongation factor...; Region: mtIF2_IVc; cd03692 114615000217 ribosome-binding factor A; Validated; Region: rbfA; PRK00521 114615000218 tRNA pseudouridine synthase B; Provisional; Region: truB; PRK05389 114615000219 Pseudouridine synthase, Escherichia coli TruB like; Region: PseudoU_synth_EcTruB; cd02573 114615000220 RNA binding site [nucleotide binding]; other site 114615000221 active site 114615000222 Ribosomal protein S15 (prokaryotic)_S13 (eukaryotic) binds the central domain of 16S rRNA and is required for assembly of the small ribosomal subunit and for intersubunit association, thus representing a key element in the assembly of the whole ribosome; Region: Ribosomal_S15p_S13e; cd00353 114615000223 16S/18S rRNA binding site [nucleotide binding]; other site 114615000224 S13e-L30e interaction site [polypeptide binding]; other site 114615000225 25S rRNA binding site [nucleotide binding]; other site 114615000226 polynucleotide phosphorylase/polyadenylase; Provisional; Region: PRK11824 114615000227 Polyribonucleotide nucleotidyltransferase, repeat 1; Region: RNase_PH_PNPase_1; cd11363 114615000228 RNase E interface [polypeptide binding]; other site 114615000229 trimer interface [polypeptide binding]; other site 114615000230 Polyribonucleotide nucleotidyltransferase, RNA binding domain; Region: PNPase; pfam03726 114615000231 Polyribonucleotide nucleotidyltransferase, repeat 2; Region: RNase_PH_PNPase_2; cd11364 114615000232 RNase E interface [polypeptide binding]; other site 114615000233 trimer interface [polypeptide binding]; other site 114615000234 active site 114615000235 Polynucleotide phosphorylase (PNPase) K homology RNA-binding domain (KH). PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA in prokaryotes and plant chloroplasts. The C-terminal region of PNPase contains domains homologous to...; Region: PNPase_KH; cd02393 114615000236 putative nucleic acid binding region [nucleotide binding]; other site 114615000237 G-X-X-G motif; other site 114615000238 S1_PNPase: Polynucleotide phosphorylase (PNPase), ), S1-like RNA-binding domain. PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA. It is a trimeric multidomain protein. The C-terminus contains the S1 domain which binds ssRNA; Region: S1_PNPase; cd04472 114615000239 RNA binding site [nucleotide binding]; other site 114615000240 domain interface; other site 114615000241 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 114615000242 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 114615000243 Coenzyme A binding pocket [chemical binding]; other site 114615000244 Autotransporter beta-domain; Region: Autotransporter; pfam03797 114615000245 enoyl-(acyl carrier protein) reductase; Provisional; Region: PRK06505 114615000246 Enoyl acyl carrier protein (ACP) reductase (ENR), divergent SDR; Region: ENR_SDR; cd05372 114615000247 NAD binding site [chemical binding]; other site 114615000248 homotetramer interface [polypeptide binding]; other site 114615000249 homodimer interface [polypeptide binding]; other site 114615000250 substrate binding site [chemical binding]; other site 114615000251 active site 114615000252 3-oxoacyl-(acyl carrier protein) synthase I; Reviewed; Region: PRK07967 114615000253 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 114615000254 dimer interface [polypeptide binding]; other site 114615000255 active site 114615000256 3-hydroxydecanoyl-(acyl carrier protein) dehydratase; Validated; Region: PRK05174 114615000257 active site 2 [active] 114615000258 active site 1 [active] 114615000259 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 114615000260 metal binding site 2 [ion binding]; metal-binding site 114615000261 putative DNA binding helix; other site 114615000262 metal binding site 1 [ion binding]; metal-binding site 114615000263 dimer interface [polypeptide binding]; other site 114615000264 structural Zn2+ binding site [ion binding]; other site 114615000265 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3807 114615000266 Bacterial SH3 domain; Region: SH3_4; pfam06347 114615000267 Bacterial SH3 domain; Region: SH3_4; pfam06347 114615000268 Lactate dehydrogenase and related dehydrogenases [Energy production and conversion / Coenzyme metabolism / General function prediction only]; Region: LdhA; COG1052 114615000269 D-glycerate dehydrogenase/hydroxypyruvate reductase (GDH); Region: GDH; cd05301 114615000270 dimerization interface [polypeptide binding]; other site 114615000271 ligand binding site [chemical binding]; other site 114615000272 NADP binding site [chemical binding]; other site 114615000273 catalytic site [active] 114615000274 Transcriptional regulator [Transcription]; Region: LysR; COG0583 114615000275 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 114615000276 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_5; cd08474 114615000277 putative effector binding pocket; other site 114615000278 putative dimerization interface [polypeptide binding]; other site 114615000279 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 114615000280 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 114615000281 active site 114615000282 catalytic tetrad [active] 114615000283 molybdopterin biosynthesis protein MoeB; Provisional; Region: PRK05690 114615000284 ThiF_MoeB_HesA. Family of E1-like enzymes involved in molybdopterin and thiamine biosynthesis family. The common reaction mechanism catalyzed by MoeB and ThiF, like other E1 enzymes, begins with a nucleophilic attack of the C-terminal carboxylate of MoaD...; Region: ThiF_MoeB_HesA_family; cd00757 114615000285 ATP binding site [chemical binding]; other site 114615000286 substrate interface [chemical binding]; other site 114615000287 His-Xaa-Ser repeat protein HxsA; Region: His_Ser_Rich; TIGR03979 114615000288 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 114615000289 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 114615000290 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 114615000291 ParA-like protein; Provisional; Region: PHA02518 114615000292 P-loop; other site 114615000293 Magnesium ion binding site [ion binding]; other site 114615000294 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 114615000295 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 114615000296 ligand binding site [chemical binding]; other site 114615000297 formamidopyrimidine/5-formyluracil/ 5-hydroxymethyluracil DNA glycosylase; Validated; Region: PRK01103 114615000298 N-terminal domain of Escherichia coli Fpg1/MutM and related bacterial DNA glycosylases; Region: EcFpg-like_N; cd08966 114615000299 DNA binding site [nucleotide binding] 114615000300 catalytic residue [active] 114615000301 H2TH interface [polypeptide binding]; other site 114615000302 putative catalytic residues [active] 114615000303 turnover-facilitating residue; other site 114615000304 intercalation triad [nucleotide binding]; other site 114615000305 8OG recognition residue [nucleotide binding]; other site 114615000306 putative reading head residues; other site 114615000307 Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831 114615000308 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 114615000309 Methylase involved in ubiquinone/menaquinone biosynthesis [Coenzyme metabolism]; Region: UbiE; COG2226 114615000310 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 114615000311 S-adenosylmethionine binding site [chemical binding]; other site 114615000312 ABC1 family; Region: ABC1; cl17513 114615000313 2-polyprenylphenol 6-hydroxylase; Region: UbiB; TIGR01982 114615000314 bifunctional SbtC-like/phosphopantothenoylcysteine decarboxylase/phosphopantothenate synthase; Provisional; Region: PRK13982 114615000315 Plasmid stability protein [General function prediction only]; Region: StbC; COG4691 114615000316 Flavoprotein; Region: Flavoprotein; pfam02441 114615000317 DNA / pantothenate metabolism flavoprotein; Region: DFP; pfam04127 114615000318 Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557 114615000319 trimer interface [polypeptide binding]; other site 114615000320 active site 114615000321 PAS fold; Region: PAS_7; pfam12860 114615000322 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 114615000323 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 114615000324 dimer interface [polypeptide binding]; other site 114615000325 phosphorylation site [posttranslational modification] 114615000326 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 114615000327 ATP binding site [chemical binding]; other site 114615000328 Mg2+ binding site [ion binding]; other site 114615000329 G-X-G motif; other site 114615000330 Predicted ATPase or kinase [General function prediction only]; Region: COG0802 114615000331 Predicted phosphotransferase related to Ser/Thr protein kinases [General function prediction only]; Region: COG3178 114615000332 Phosphotransferase enzyme family; Region: APH; pfam01636 114615000333 PilZ domain; Region: PilZ; pfam07238 114615000334 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis/translation initiation factor 2B, gamma/epsilon subunits (eIF-2Bgamma/eIF-2Bepsilon) [Cell envelope biogenesis, outer membrane / Translation, ribosomal structure...; Region: GCD1; COG1208 114615000335 NTP_transferase_like_1 is a member of the nucleotidyl transferase family; Region: NTP_transferase_like_1; cd06422 114615000336 Substrate binding site; other site 114615000337 metal-binding site 114615000338 double-strand break repair protein AddB, alphaproteobacterial type; Region: addB_alphas; TIGR02786 114615000339 CRISPR/Cas system-associated protein Cas4; Region: Cas4_I-A_I-B_I-C_I-D_II-B; cl00641 114615000340 double-strand break repair helicase AddA, alphaproteobacterial type; Region: addA_alphas; TIGR02784 114615000341 Part of AAA domain; Region: AAA_19; pfam13245 114615000342 Family description; Region: UvrD_C_2; pfam13538 114615000343 PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705 114615000344 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 114615000345 catalytic residues [active] 114615000346 ATP-dependent DNA ligase; Reviewed; Region: ligC; PRK08224 114615000347 Adenylation domain of Mycobacterium tuberculosis LigC-like ATP-dependent DNA ligases; Region: Adenylation_DNA_ligase_LigC; cd07905 114615000348 active site 114615000349 DNA binding site [nucleotide binding] 114615000350 The Oligonucleotide/oligosaccharide binding (OB)-fold domain of ATP-dependent DNA ligase LigC is a DNA-binding module that is part of the catalytic core unit; Region: OBF_DNA_ligase_LigC; cd07970 114615000351 DNA binding site [nucleotide binding] 114615000352 Calcineurin-like phosphoesterase superfamily domain; Region: Metallophos_2; pfam12850 114615000353 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 114615000354 active site 114615000355 metal binding site [ion binding]; metal-binding site 114615000356 Folylpolyglutamate synthase [Coenzyme metabolism]; Region: FolC; COG0285 114615000357 Amidinotransferase; Region: Amidinotransf; cl12043 114615000358 acetyl-CoA carboxylase subunit beta; Validated; Region: PRK05654 114615000359 malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682 114615000360 Ttryptophan synthase (TRPS) alpha subunit (TSA). TPRS is a bifunctional tetrameric enzyme (2 alpha and 2 beta subunits) that catalyzes the last two steps of L-tryptophan biosynthesis. Alpha and beta subunit catalyze two distinct reactions which are both...; Region: Tryptophan_synthase_alpha; cd04724 114615000361 substrate binding site [chemical binding]; other site 114615000362 active site 114615000363 catalytic residues [active] 114615000364 heterodimer interface [polypeptide binding]; other site 114615000365 tryptophan synthase, beta subunit; Region: trpB; TIGR00263 114615000366 Tryptophan synthase-beta: Trptophan synthase is a bifunctional enzyme that catalyses the last two steps in the biosynthesis of L-tryptophan via its alpha and beta reactions. In the alpha reaction, indole 3-glycerol phosphate is cleaved reversibly to...; Region: Trp-synth_B; cd06446 114615000367 pyridoxal 5'-phosphate binding site [chemical binding]; other site 114615000368 catalytic residue [active] 114615000369 Phosphoribosylanthranilate isomerase (PRAI) catalyzes the fourth step of the tryptophan biosynthesis, the conversion of N-(5'- phosphoribosyl)-anthranilate (PRA) to 1-(o-carboxyphenylamino)- 1-deoxyribulose 5-phosphate (CdRP). Most PRAIs are...; Region: PRAI; cd00405 114615000370 active site 114615000371 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 114615000372 IHF dimer interface [polypeptide binding]; other site 114615000373 IHF - DNA interface [nucleotide binding]; other site 114615000374 Signal peptide peptidase A (SppA), a serine protease, has catalytic Ser-Lys dyad; Region: S49_Sppa_N_C; cd07023 114615000375 signal peptide peptidase SppA, 36K type; Region: SppA_dom; TIGR00706 114615000376 tandem repeat interface [polypeptide binding]; other site 114615000377 oligomer interface [polypeptide binding]; other site 114615000378 active site residues [active] 114615000379 30S ribosomal protein S1; Reviewed; Region: rpsA; PRK06299 114615000380 S1_RPS1_repeat_ec1_hs1: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec1_hs1; cd05687 114615000381 RNA binding site [nucleotide binding]; other site 114615000382 S1_RPS1_repeat_ec2_hs2: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec2_hs2; cd04465 114615000383 RNA binding site [nucleotide binding]; other site 114615000384 S1_RPS1_repeat_ec3: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec3; cd05688 114615000385 RNA binding site [nucleotide binding]; other site 114615000386 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 114615000387 RNA binding site [nucleotide binding]; other site 114615000388 S1_RPS1_repeat_ec5: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec5; cd05690 114615000389 RNA binding site [nucleotide binding]; other site 114615000390 S1_RPS1_repeat_ec6: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec6; cd05691 114615000391 RNA binding site [nucleotide binding]; other site 114615000392 cytidylate kinase; Provisional; Region: cmk; PRK00023 114615000393 Cytidine monophosphate kinase (CMPK) catalyzes the reversible phosphorylation of cytidine monophosphate (CMP) to produce cytidine diphosphate (CDP), using ATP as the preferred phosphoryl donor; Region: CMPK; cd02020 114615000394 CMP-binding site; other site 114615000395 The sites determining sugar specificity; other site 114615000396 3-phosphoshikimate 1-carboxyvinyltransferase; Provisional; Region: PRK02427 114615000397 EPSP synthase domain. 3-phosphoshikimate 1-carboxyvinyltransferase (5-enolpyruvylshikimate-3-phosphate synthase) (EC 2.5.1.19) catalyses the reaction between shikimate-3-phosphate (S3P) and phosphoenolpyruvate (PEP) to form...; Region: EPSP_synthase; cd01556 114615000398 hinge; other site 114615000399 active site 114615000400 TIGR02300 family protein; Region: FYDLN_acid 114615000401 Protein of unknown function (FYDLN_acid); Region: FYDLN_acid; pfam09538 114615000402 Catalytic GIY-YIG domain of yeast structure-specific endonuclease subunit SLX1 and its homologs; Region: GIY-YIG_SLX1_like; cd10449 114615000403 GIY-YIG motif/motif A; other site 114615000404 putative active site [active] 114615000405 putative metal binding site [ion binding]; other site 114615000406 Transcriptional regulators [Transcription]; Region: MarR; COG1846 114615000407 MarR family; Region: MarR; pfam01047 114615000408 peroxiredoxin, Ohr subfamily; Region: organ_hyd_perox; TIGR03561 114615000409 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 114615000410 CoA-transferase family III; Region: CoA_transf_3; pfam02515 114615000411 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 114615000412 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 114615000413 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 114615000414 putative PBP binding loops; other site 114615000415 dimer interface [polypeptide binding]; other site 114615000416 ABC-ATPase subunit interface; other site 114615000417 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 114615000418 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 114615000419 dimer interface [polypeptide binding]; other site 114615000420 conserved gate region; other site 114615000421 putative PBP binding loops; other site 114615000422 ABC-ATPase subunit interface; other site 114615000423 glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650 114615000424 The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301 114615000425 Walker A/P-loop; other site 114615000426 ATP binding site [chemical binding]; other site 114615000427 Q-loop/lid; other site 114615000428 ABC transporter signature motif; other site 114615000429 Walker B; other site 114615000430 D-loop; other site 114615000431 H-loop/switch region; other site 114615000432 TOBE domain; Region: TOBE_2; pfam08402 114615000433 Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071 114615000434 Alpha-crystallin domain (ACD) found in Escherichia coli inclusion body-associated proteins IbpA and IbpB, and similar proteins. IbpA and IbpB are 16 kDa small heat shock proteins (sHsps). sHsps are molecular chaperones that suppress protein aggregation...; Region: ACD_IbpA-B_like; cd06470 114615000435 putative dimer interface [polypeptide binding]; other site 114615000436 Protein of unknown function (DUF1150); Region: DUF1150; pfam06620 114615000437 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 114615000438 Coenzyme A binding pocket [chemical binding]; other site 114615000439 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 114615000440 active site 114615000441 phosphorylation site [posttranslational modification] 114615000442 RaiA ("ribosome-associated inhibitor A", also known as Protein Y (PY), YfiA, and SpotY, is a stress-response protein that binds the ribosomal subunit interface and arrests translation by interfering with aminoacyl-tRNA binding to the ribosomal...; Region: RaiA; cd00552 114615000443 30S subunit binding site; other site 114615000444 RNA polymerase factor sigma-54; Provisional; Region: PRK12469 114615000445 Sigma-54 factor, Activator interacting domain (AID); Region: Sigma54_AID; pfam00309 114615000446 Sigma-54 factor, core binding domain; Region: Sigma54_CBD; pfam04963 114615000447 Sigma-54, DNA binding domain; Region: Sigma54_DBD; pfam04552 114615000448 ABC-type (unclassified) transport system, ATPase component [General function prediction only]; Region: YhbG; COG1137 114615000449 ATP-binding cassette component of YhbG transport system; Region: ABC_YhbG; cd03218 114615000450 Walker A/P-loop; other site 114615000451 ATP binding site [chemical binding]; other site 114615000452 Q-loop/lid; other site 114615000453 ABC transporter signature motif; other site 114615000454 Walker B; other site 114615000455 D-loop; other site 114615000456 H-loop/switch region; other site 114615000457 lipopolysaccharide transport periplasmic protein LptA; Region: outer_YhbN_LptA; TIGR03002 114615000458 OstA-like protein; Region: OstA; pfam03968 114615000459 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5375 114615000460 Ribonuclease D [Translation, ribosomal structure and biogenesis]; Region: Rnd; COG0349 114615000461 DEDDy 3'-5' exonuclease domain of Ribonuclease D and similar proteins; Region: RNaseD_exo; cd06142 114615000462 catalytic site [active] 114615000463 putative active site [active] 114615000464 putative substrate binding site [chemical binding]; other site 114615000465 TRAP-type C4-dicarboxylate transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: DctP; COG1638 114615000466 Bacterial extracellular solute-binding protein, family 7; Region: SBP_bac_7; pfam03480 114615000467 TRAP-type C4-dicarboxylate transport system, small permease component [Carbohydrate transport and metabolism]; Region: DctM; COG3090 114615000468 DctM-like transporters; Region: DctM; pfam06808 114615000469 TRAP-type C4-dicarboxylate transport system, large permease component [Carbohydrate transport and metabolism]; Region: DctQ; COG1593 114615000470 Bacterial periplasmic substrate-binding proteins; Region: PBPb; smart00062 114615000471 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 114615000472 substrate binding pocket [chemical binding]; other site 114615000473 membrane-bound complex binding site; other site 114615000474 hinge residues; other site 114615000475 Cytochrome C oxidase, cbb3-type, subunit III; Region: Cytochrome_CBB3; pfam13442 114615000476 PQQ-dependent dehydrogenases and related proteins; Region: PQQ_DH_like; cl11493 114615000477 PQQ-dependent dehydrogenase, methanol/ethanol family; Region: PQQ_enz_alc_DH; TIGR03075 114615000478 Trp docking motif [polypeptide binding]; other site 114615000479 active site 114615000480 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084 114615000481 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 114615000482 Predicted nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG0702 114615000483 NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, subunit 9, 39 kDa, (NDUFA9) -like, atypical (a) SDRs; Region: NDUFA9_like_SDR_a; cd05271 114615000484 putative NAD(P) binding site [chemical binding]; other site 114615000485 active site 114615000486 undecaprenyl pyrophosphate phosphatase; Reviewed; Region: PRK00281 114615000487 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 114615000488 Glutathione S-transferase (GST) family, N-terminal domain; a large, diverse group of cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of endogenous and xenobiotic...; Region: GST_N_family; cd00570 114615000489 C-terminal domain interface [polypeptide binding]; other site 114615000490 GSH binding site (G-site) [chemical binding]; other site 114615000491 dimer interface [polypeptide binding]; other site 114615000492 C-terminal, alpha helical domain of the Glutathione S-transferase family; Region: GST_C_family; cl02776 114615000493 N-terminal domain interface [polypeptide binding]; other site 114615000494 dimer interface [polypeptide binding]; other site 114615000495 substrate binding pocket (H-site) [chemical binding]; other site 114615000496 Domain of unknown function (DUF1730); Region: DUF1730; pfam08331 114615000497 4Fe-4S double cluster binding domain; Region: Fer4_16; pfam13484 114615000498 HEAT repeats; Region: HEAT_2; pfam13646 114615000499 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 114615000500 translation initiation factor IF-3; Reviewed; Region: infC; PRK00028 114615000501 Translation initiation factor IF-3, N-terminal domain; Region: IF3_N; pfam05198 114615000502 Translation initiation factor IF-3, C-terminal domain; Region: IF3_C; pfam00707 114615000503 50S ribosomal protein L35; Reviewed; Region: rpmI; PRK00172 114615000504 Ribosomal protein L20; Region: Ribosomal_L20; cd07026 114615000505 23S rRNA binding site [nucleotide binding]; other site 114615000506 L21 binding site [polypeptide binding]; other site 114615000507 L13 binding site [polypeptide binding]; other site 114615000508 phenylalanyl-tRNA synthetase subunit alpha; Validated; Region: pheS; PRK00488 114615000509 Aminoacyl tRNA synthetase class II, N-terminal domain; Region: Phe_tRNA-synt_N; pfam02912 114615000510 Phenylalanyl-tRNA synthetase (PheRS) alpha chain catalytic core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs. This domain is primarily responsible...; Region: PheRS_alpha_core; cd00496 114615000511 dimer interface [polypeptide binding]; other site 114615000512 motif 1; other site 114615000513 active site 114615000514 motif 2; other site 114615000515 motif 3; other site 114615000516 ASC-1 homology domain, subfamily similar to Enterococcus faecalis Ef3133. The ASCH domain, a small beta-barrel domain found in all three kingdoms of life, resembles the RNA-binding PUA domain and may also interact with RNA. ASCH has been proposed to...; Region: ASCH_Ef3133_like; cd06553 114615000517 phenylalanyl-tRNA synthetase subunit beta; Reviewed; Region: pheT; PRK00629 114615000518 tRNA-binding-domain-containing prokaryotic phenylalanly tRNA synthetase (PheRS) beta chain. PheRS aminoacylate phenylalanine transfer RNAs (tRNAphe). PheRSs belong structurally to class II aminoacyl tRNA synthetases (aaRSs) but, as they aminoacylate...; Region: tRNA_bind_bactPheRS; cd02796 114615000519 putative tRNA-binding site [nucleotide binding]; other site 114615000520 B3/4 domain; Region: B3_4; pfam03483 114615000521 tRNA synthetase B5 domain; Region: B5; smart00874 114615000522 Phenylalanyl-tRNA synthetase (PheRS) beta chain core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure. While class II aaRSs generally aminoacylate the 3'-OH ribose of the appropriate tRNA, PheRS is an...; Region: PheRS_beta_core; cd00769 114615000523 dimer interface [polypeptide binding]; other site 114615000524 motif 1; other site 114615000525 motif 3; other site 114615000526 motif 2; other site 114615000527 Ferredoxin-fold anticodon binding domain; Region: FDX-ACB; smart00896 114615000528 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 114615000529 Metal-dependent hydrolases of the beta-lactamase superfamily III [General function prediction only]; Region: ElaC; COG1234 114615000530 Flavin containing amine oxidoreductase; Region: Amino_oxidase; pfam01593 114615000531 Orthopoxvirus protein of unknown function (DUF830); Region: DUF830; cl13998 114615000532 Transcriptional regulators CsoR (copper-sensitive operon repressor), RcnR, and FrmR, and related domains; this domain superfamily was previously known as DUF156; Region: CsoR-like_DUF156; cd10148 114615000533 putative homodimer interface [polypeptide binding]; other site 114615000534 putative homotetramer interface [polypeptide binding]; other site 114615000535 putative allosteric switch controlling residues; other site 114615000536 putative metal binding site [ion binding]; other site 114615000537 putative homodimer-homodimer interface [polypeptide binding]; other site 114615000538 metallochaperone-like domain; Region: TRASH; smart00746 114615000539 YHS domain; Region: YHS; pfam04945 114615000540 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 114615000541 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 114615000542 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 114615000543 motif II; other site 114615000544 CysZ-like protein; Reviewed; Region: PRK12768 114615000545 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 114615000546 putative substrate translocation pore; other site 114615000547 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 114615000548 Phospholipid methyltransferase; Region: PEMT; cl17370 114615000549 Predicted naringenin-chalcone synthase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: BcsA; COG3424 114615000550 Chalcone and stilbene synthases; plant-specific polyketide synthases (PKS) and related enzymes, also called type III PKSs. PKS generate an array of different products, dependent on the nature of the starter molecule. They share a common chemical strategy; Region: CHS_like; cd00831 114615000551 malonyl-CoA binding site [chemical binding]; other site 114615000552 dimer interface [polypeptide binding]; other site 114615000553 active site 114615000554 product binding site; other site 114615000555 Predicted EndoIII-related endonuclease [DNA replication, recombination, and repair]; Region: Nth; COG0177 114615000556 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 114615000557 minor groove reading motif; other site 114615000558 helix-hairpin-helix signature motif; other site 114615000559 substrate binding pocket [chemical binding]; other site 114615000560 active site 114615000561 iron-sulpphur binding domain in DNA-(apurinic or apyrimidinic site) lyase (subfamily of ENDO3); Region: FES; smart00525 114615000562 Integral membrane protein (DUF2244); Region: DUF2244; pfam10003 114615000563 Helix-turn-helix domain; Region: HTH_18; pfam12833 114615000564 Methylated DNA-protein cysteine methyltransferase [DNA replication, recombination, and repair]; Region: Ada; COG0350 114615000565 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 114615000566 DNA binding site [nucleotide binding] 114615000567 active site 114615000568 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 114615000569 catalytic core [active] 114615000570 dihydrodipicolinate reductase; Provisional; Region: PRK00048 114615000571 Dihydrodipicolinate reductase, N-terminus; Region: DapB_N; pfam01113 114615000572 Dihydrodipicolinate reductase, C-terminus; Region: DapB_C; pfam05173 114615000573 Uncharacterized conserved protein [Function unknown]; Region: COG5470 114615000574 Orotidine 5'-phosphate decarboxylase (ODCase) is a dimeric enzyme that decarboxylates orotidine 5'-monophosphate (OMP) to form uridine 5'-phosphate (UMP), an essential step in the pyrimidine biosynthetic pathway. In mammals, UMP synthase...; Region: OMP_decarboxylase_like; cd04725 114615000575 active site 114615000576 dimer interface [polypeptide binding]; other site 114615000577 Predicted flavoprotein [General function prediction only]; Region: COG0431 114615000578 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 114615000579 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 114615000580 S-adenosylmethionine binding site [chemical binding]; other site 114615000581 chaperone protein DnaJ; Provisional; Region: PRK10767 114615000582 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 114615000583 HSP70 interaction site [polypeptide binding]; other site 114615000584 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cl03262 114615000585 substrate binding site [polypeptide binding]; other site 114615000586 Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719 114615000587 Zn binding sites [ion binding]; other site 114615000588 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747 114615000589 dimer interface [polypeptide binding]; other site 114615000590 molecular chaperone DnaK; Provisional; Region: dnaK; PRK00290 114615000591 Nucleotide-binding domain of human HSPA9, Escherichia coli DnaK, and similar proteins; Region: HSPA9-like_NBD; cd11733 114615000592 nucleotide binding site [chemical binding]; other site 114615000593 NEF interaction site [polypeptide binding]; other site 114615000594 SBD interface [polypeptide binding]; other site 114615000595 Methyltransferase domain; Region: Methyltransf_23; pfam13489 114615000596 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 114615000597 S-adenosylmethionine binding site [chemical binding]; other site 114615000598 undecaprenyl phosphate 4-deoxy-4-formamido-L-arabinose transferase; Provisional; Region: PRK10714 114615000599 Bacterial DPM1_like enzymes are related to eukaryotic DPM1; Region: DPM1_like_bac; cd04187 114615000600 Ligand binding site; other site 114615000601 Putative Catalytic site; other site 114615000602 DXD motif; other site 114615000603 Methyltransferase domain; Region: Methyltransf_23; pfam13489 114615000604 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 114615000605 S-adenosylmethionine binding site [chemical binding]; other site 114615000606 Molecular chaperone GrpE (heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: GrpE; COG0576 114615000607 GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70)-type ATPases. The GrpE dimer binds to the ATPase domain of Hsp70 catalyzing the dissociation of ADP, which enables rebinding of ATP, one step in the Hsp70 reaction cycle in protein folding; Region: GrpE; cd00446 114615000608 dimer interface [polypeptide binding]; other site 114615000609 hsp70 (ATPase domain) interactions [polypeptide binding]; other site 114615000610 heat-inducible transcription repressor; Provisional; Region: hrcA; PRK00082 114615000611 ribonuclease PH; Reviewed; Region: rph; PRK00173 114615000612 Ribonuclease PH; Region: RNase_PH_bact; cd11362 114615000613 hexamer interface [polypeptide binding]; other site 114615000614 active site 114615000615 NTPase/HAM1. This family consists of the HAM1 protein and pyrophosphate-releasing xanthosine/ inosine triphosphatase. HAM1 protects the cell against mutagenesis by the base analog 6-N-hydroxylaminopurine (HAP) in E. Coli and S. cerevisiae. A...; Region: HAM1; cd00515 114615000616 active site 114615000617 dimerization interface [polypeptide binding]; other site 114615000618 coproporphyrinogen III oxidase; Provisional; Region: PRK09057 114615000619 HemN C-terminal domain; Region: HemN_C; pfam06969 114615000620 Periplasmic binding component of lipoprotein LppC, an immunodominant antigen; Region: PBP1_YraM_LppC_lipoprotein_like; cd06339 114615000621 putative ligand binding site [chemical binding]; other site 114615000622 Predicted methyltransferases [General function prediction only]; Region: COG0313 114615000623 Ribosomal RNA small subunit methyltransferase I, also known as rRNA (cytidine-2'-O-)-methyltransferase RsmI; Region: RsmI; cd11648 114615000624 putative SAM binding site [chemical binding]; other site 114615000625 putative homodimer interface [polypeptide binding]; other site 114615000626 hypothetical protein; Reviewed; Region: PRK12497 114615000627 glutathione synthetase; Provisional; Region: PRK05246 114615000628 Prokaryotic glutathione synthetase, N-terminal domain; Region: GSH-S_N; pfam02951 114615000629 Prokaryotic glutathione synthetase, ATP-grasp domain; Region: GSH-S_ATP; pfam02955 114615000630 Escherichia coli exonuclease III (ExoIII) and Neisseria meningitides NExo-like subfamily of the ExoIII family purinic/apyrimidinic (AP) endonucleases; Region: ExoIII-like_AP-endo; cd09086 114615000631 putative catalytic site [active] 114615000632 putative phosphate binding site [ion binding]; other site 114615000633 active site 114615000634 metal binding site A [ion binding]; metal-binding site 114615000635 DNA binding site [nucleotide binding] 114615000636 putative AP binding site [nucleotide binding]; other site 114615000637 putative metal binding site B [ion binding]; other site 114615000638 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 114615000639 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 114615000640 ligand binding site [chemical binding]; other site 114615000641 flexible hinge region; other site 114615000642 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 114615000643 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 114615000644 active site 114615000645 phosphorylation site [posttranslational modification] 114615000646 intermolecular recognition site; other site 114615000647 dimerization interface [polypeptide binding]; other site 114615000648 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 114615000649 DNA binding site [nucleotide binding] 114615000650 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3786 114615000651 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; cl11421 114615000652 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes, YBL036c-like proteins; Region: PLPDE_III_YBL036c_like; cd00635 114615000653 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 114615000654 catalytic residue [active] 114615000655 HAMP domain; Region: HAMP; pfam00672 114615000656 dimerization interface [polypeptide binding]; other site 114615000657 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 114615000658 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 114615000659 metal binding site [ion binding]; metal-binding site 114615000660 active site 114615000661 I-site; other site 114615000662 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 114615000663 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 114615000664 metal binding site [ion binding]; metal-binding site 114615000665 active site 114615000666 I-site; other site 114615000667 leucyl-tRNA synthetase; Validated; Region: leuS; PRK00390 114615000668 catalytic core domain of leucyl-tRNA synthetases; Region: LeuRS_core; cd00812 114615000669 HIGH motif; other site 114615000670 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 114615000671 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 114615000672 active site 114615000673 KMSKS motif; other site 114615000674 Anticodon-binding domain of bacterial and eukaryotic mitochondrial leucyl tRNA synthetases; Region: Anticodon_Ia_Leu_BEm; cd07958 114615000675 tRNA binding surface [nucleotide binding]; other site 114615000676 Lipopolysaccharide-assembly; Region: LptE; pfam04390 114615000677 DNA polymerase III subunit delta; Reviewed; Region: holA; PRK06585 114615000678 DNA polymerase III, delta subunit; Region: DNA_pol3_delta; pfam06144 114615000679 ParB/RepB/Spo0J family partition protein; Region: parB_part; TIGR00180 114615000680 ParB-like nuclease domain; Region: ParB; smart00470 114615000681 KorB domain; Region: KorB; pfam08535 114615000682 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 114615000683 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 114615000684 P-loop; other site 114615000685 Magnesium ion binding site [ion binding]; other site 114615000686 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 114615000687 Magnesium ion binding site [ion binding]; other site 114615000688 16S rRNA methyltransferase GidB; Reviewed; Region: gidB; PRK00107 114615000689 rRNA small subunit methyltransferase G; Region: GidB; pfam02527 114615000690 tRNA uridine 5-carboxymethylaminomethyl modification enzyme GidA; Validated; Region: PRK05192 114615000691 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 114615000692 tRNA (uracil-5-)-methyltransferase Gid; Reviewed; Region: PRK05335 114615000693 GidA associated domain 3; Region: GIDA_assoc_3; pfam13932 114615000694 tRNA modification GTPase TrmE; Reviewed; Region: trmE; PRK05291 114615000695 GTP-binding protein TrmE N-terminus; Region: TrmE_N; pfam10396 114615000696 trmE is a tRNA modification GTPase; Region: trmE; cd04164 114615000697 G1 box; other site 114615000698 GTP/Mg2+ binding site [chemical binding]; other site 114615000699 Switch I region; other site 114615000700 G2 box; other site 114615000701 Switch II region; other site 114615000702 G3 box; other site 114615000703 G4 box; other site 114615000704 G5 box; other site 114615000705 Catalytic cysteine-containing C-terminus of GTPase, MnmE; Region: GTPase_Cys_C; pfam12631 114615000706 transcription termination factor Rho; Provisional; Region: rho; PRK09376 114615000707 Rho termination factor, N-terminal domain; Region: Rho_N; pfam07498 114615000708 Rho_CSD: Rho protein cold-shock domain (CSD). Rho protein is a transcription termination factor in most bacteria. In bacteria, there are two distinct mechanisms for mRNA transcription termination. In intrinsic termination, RNA polymerase and nascent mRNA...; Region: Rho_CSD; cd04459 114615000709 RNA binding site [nucleotide binding]; other site 114615000710 Transcription termination factor rho is a bacterial ATP-dependent RNA/DNA helicase. It is a homohexamer. Each monomer consists of an N-terminal domain of the OB fold, which is responsible for binding to cysteine rich nucleotides. This alignment is of the...; Region: rho_factor; cd01128 114615000711 multimer interface [polypeptide binding]; other site 114615000712 Walker A motif; other site 114615000713 ATP binding site [chemical binding]; other site 114615000714 Walker B motif; other site 114615000715 Uncharacterized protein family (UPF0093); Region: UPF0093; pfam03653 114615000716 PEP synthetase regulatory protein; Provisional; Region: PRK05339 114615000717 Nucleotide binding protein Maf. Maf has been implicated in inhibition of septum formation in eukaryotes, bacteria and archaea, but homologs in B.subtilis and S.cerevisiae are nonessential for cell division. Maf has been predicted to be a nucleotide- or...; Region: Maf; cd00555 114615000718 active site 114615000719 dimer interface [polypeptide binding]; other site 114615000720 Dephospho-CoA kinase [Coenzyme metabolism]; Region: CoaE; COG0237 114615000721 Dephospho-coenzyme A kinase (DPCK, EC 2.7.1.24) catalyzes the phosphorylation of dephosphocoenzyme A (dCoA) to yield CoA, which is the final step in CoA biosynthesis; Region: DPCK; cd02022 114615000722 CoA-binding site [chemical binding]; other site 114615000723 ATP-binding [chemical binding]; other site 114615000724 DNA polymerase III, epsilon subunit, Proteobacterial; Region: dnaQ_proteo; TIGR01406 114615000725 DEDDh 3'-5' exonuclease domain of the epsilon subunit of Escherichia coli DNA polymerase III and similar proteins; Region: DNA_pol_III_epsilon_Ecoli_like; cd06131 114615000726 active site 114615000727 catalytic site [active] 114615000728 substrate binding site [chemical binding]; other site 114615000729 preprotein translocase subunit SecB; Validated; Region: PRK05751 114615000730 SecA binding site; other site 114615000731 Preprotein binding site; other site 114615000732 Tim44-like domain; Region: Tim44; pfam04280 114615000733 Membrane-bound lytic murein transglycosylase [Cell envelope biogenesis, outer membrane]; Region: MltA; COG2821 114615000734 MltA specific insert domain; Region: MltA; smart00925 114615000735 3D domain; Region: 3D; pfam06725 114615000736 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2840 114615000737 Smr domain; Region: Smr; pfam01713 114615000738 ATP-dependent protease ATP-binding subunit HslU; Provisional; Region: hslU; PRK05201 114615000739 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 114615000740 Walker A motif; other site 114615000741 ATP binding site [chemical binding]; other site 114615000742 AAA domain (Cdc48 subfamily); Region: AAA_2; pfam07724 114615000743 Walker B motif; other site 114615000744 arginine finger; other site 114615000745 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 114615000746 Acetyltransferase (GNAT) domain; Region: Acetyltransf_8; pfam13523 114615000747 Siderophore biosynthesis protein domain; Region: AlcB; smart01006 114615000748 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 114615000749 Protein of unknown function (DUF2585); Region: DUF2585; cl07906 114615000750 Protease HslV and the ATPase/chaperone HslU are part of an ATP-dependent proteolytic system that is the prokaryotic homolog of the proteasome. HslV is a dimer of hexamers (a dodecamer) that forms a central proteolytic chamber with active sites on the...; Region: protease_HslV; cd01913 114615000751 active site 114615000752 HslU subunit interaction site [polypeptide binding]; other site 114615000753 Imidazoleglycerol-phosphate dehydratase; Region: IGPD; cd07914 114615000754 putative active site pocket [active] 114615000755 4-fold oligomerization interface [polypeptide binding]; other site 114615000756 metal binding residues [ion binding]; metal-binding site 114615000757 3-fold/trimer interface [polypeptide binding]; other site 114615000758 Protein of unknown function (DUF2628); Region: DUF2628; pfam10947 114615000759 imidazole glycerol phosphate synthase subunit HisH; Provisional; Region: hisH; PRK13146 114615000760 Type 1 glutamine amidotransferase (GATase1) domain found in imidazole glycerol phosphate synthase (IGPS); Region: GATase1_IGP_Synthase; cd01748 114615000761 putative active site [active] 114615000762 oxyanion strand; other site 114615000763 catalytic triad [active] 114615000764 HisA. Phosphoribosylformimino-5-aminoimidazole carboxamide ribonucleotide (ProFAR) isomerase catalyzes the fourth step in histidine biosynthesis, an isomerisation of the aminoaldose moiety of ProFAR to the aminoketose of PRFAR (N-(5'-phospho-D-1...; Region: HisA; cd04732 114615000765 phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase; Region: TIGR00007 114615000766 catalytic residues [active] 114615000767 The cyclase subunit of imidazoleglycerol phosphate synthase (HisF). Imidazole glycerol phosphate synthase (IGPS) catalyzes the fifth step of histidine biosynthesis, the formation of the imidazole ring. IGPS converts N1-(5'-phosphoribulosyl)...; Region: HisF; cd04731 114615000768 Histidine biosynthesis protein; Region: His_biosynth; pfam00977 114615000769 substrate binding site [chemical binding]; other site 114615000770 glutamase interaction surface [polypeptide binding]; other site 114615000771 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in Escherichia coli phosphoribosyl-ATP pyrophosphohydrolase (HisIE or PRATP-PH) and its homologs; Region: NTP-PPase_HisIE_like; cd11534 114615000772 metal binding site [ion binding]; metal-binding site 114615000773 pantothenate kinase; Provisional; Region: PRK05439 114615000774 Pantothenate kinase (PanK) catalyzes the phosphorylation of pantothenic acid to form 4'-phosphopantothenic, which is the first of five steps in coenzyme A (CoA) biosynthetic pathway. The reaction carried out by this enzyme is a key regulatory point...; Region: PanK; cd02025 114615000775 ATP-binding site [chemical binding]; other site 114615000776 CoA-binding site [chemical binding]; other site 114615000777 Mg2+-binding site [ion binding]; other site 114615000778 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 114615000779 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 114615000780 putative active site [active] 114615000781 heme pocket [chemical binding]; other site 114615000782 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 114615000783 dimer interface [polypeptide binding]; other site 114615000784 phosphorylation site [posttranslational modification] 114615000785 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 114615000786 ATP binding site [chemical binding]; other site 114615000787 Mg2+ binding site [ion binding]; other site 114615000788 G-X-G motif; other site 114615000789 Response regulator receiver domain; Region: Response_reg; pfam00072 114615000790 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 114615000791 active site 114615000792 phosphorylation site [posttranslational modification] 114615000793 intermolecular recognition site; other site 114615000794 dimerization interface [polypeptide binding]; other site 114615000795 Predicted ATPase with chaperone activity [Posttranslational modification, protein turnover, chaperones]; Region: COG0606 114615000796 Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541 114615000797 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 114615000798 Walker A motif; other site 114615000799 ATP binding site [chemical binding]; other site 114615000800 Walker B motif; other site 114615000801 arginine finger; other site 114615000802 Magnesium chelatase, subunit ChlI; Region: Mg_chelatase_2; pfam13335 114615000803 Uncharacterized protein conserved in bacteria (DUF2336); Region: DUF2336; pfam10098 114615000804 Outer membrane lipoprotein-sorting protein [Cell envelope biogenesis, outer membrane]; Region: LolA; COG2834 114615000805 Outer membrane lipoprotein carrier protein LolA; Region: LolA; pfam03548 114615000806 Domain of unknown function (DUF4117); Region: DUF4117; pfam13491 114615000807 DNA segregation ATPase FtsK/SpoIIIE and related proteins [Cell division and chromosome partitioning]; Region: FtsK; COG1674 114615000808 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 114615000809 Ftsk gamma domain; Region: Ftsk_gamma; pfam09397 114615000810 succinyldiaminopimelate transaminase; Provisional; Region: PRK09147 114615000811 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 114615000812 pyridoxal 5'-phosphate binding site [chemical binding]; other site 114615000813 homodimer interface [polypeptide binding]; other site 114615000814 catalytic residue [active] 114615000815 outer membrane protein assembly complex, YaeT protein; Region: OM_YaeT; TIGR03303 114615000816 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 114615000817 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 114615000818 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 114615000819 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 114615000820 Surface antigen; Region: Bac_surface_Ag; pfam01103 114615000821 classical (c) SDRs; Region: SDR_c; cd05233 114615000822 NAD(P) binding site [chemical binding]; other site 114615000823 active site 114615000824 malonyl-CoA synthase; Validated; Region: PRK07514 114615000825 Malonyl-CoA synthetase (MCS); Region: MCS; cd05941 114615000826 acyl-activating enzyme (AAE) consensus motif; other site 114615000827 active site 114615000828 AMP binding site [chemical binding]; other site 114615000829 CoA binding site [chemical binding]; other site 114615000830 Succinate:quinone oxidoreductase (SQR) Type C subfamily, Succinate dehydrogenase C (SdhC) subunit; composed of bacterial SdhC and eukaryotic large cytochrome b binding (CybL) proteins. SQR catalyzes the oxidation of succinate to fumarate coupled to the...; Region: SQR_TypeC_SdhC; cd03499 114615000831 Iron-sulfur protein interface; other site 114615000832 proximal quinone binding site [chemical binding]; other site 114615000833 SdhD (CybS) interface [polypeptide binding]; other site 114615000834 proximal heme binding site [chemical binding]; other site 114615000835 Succinate:quinone oxidoreductase (SQR) Type C subfamily, Succinate dehydrogenase D (SdhD) subunit-like; composed of predominantly uncharacterized bacterial proteins with similarity to the E. coli SdhD subunit. One characterized protein is the respiratory...; Region: SQR_TypeC_SdhD_like; cd03495 114615000836 putative SdhC subunit interface [polypeptide binding]; other site 114615000837 putative proximal heme binding site [chemical binding]; other site 114615000838 putative Iron-sulfur protein interface [polypeptide binding]; other site 114615000839 putative proximal quinone binding site; other site 114615000840 succinate dehydrogenase flavoprotein subunit; Reviewed; Region: sdhA; PRK09078 114615000841 L-aspartate oxidase; Provisional; Region: PRK06175 114615000842 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 114615000843 succinate dehydrogenase iron-sulfur subunit; Reviewed; Region: sdhB; PRK05950 114615000844 2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_3; pfam13085 114615000845 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 114615000846 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 114615000847 dimer interface [polypeptide binding]; other site 114615000848 phosphorylation site [posttranslational modification] 114615000849 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 114615000850 ATP binding site [chemical binding]; other site 114615000851 Mg2+ binding site [ion binding]; other site 114615000852 G-X-G motif; other site 114615000853 Response regulator receiver domain; Region: Response_reg; pfam00072 114615000854 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 114615000855 active site 114615000856 phosphorylation site [posttranslational modification] 114615000857 intermolecular recognition site; other site 114615000858 dimerization interface [polypeptide binding]; other site 114615000859 ABC-type uncharacterized transport system, permease and ATPase components [General function prediction only]; Region: COG4178 114615000860 ABC transporter transmembrane region 2; Region: ABC_membrane_2; cl00549 114615000861 ATP-binding cassette domain of peroxisomal transporter, subfamily D; Region: ABCD_peroxisomal_ALDP; cd03223 114615000862 methyltransferase, FkbM family; Region: fkbM_fam; TIGR01444 114615000863 Uncharacterized stress protein (general stress protein 26) [General function prediction only]; Region: COG3871 114615000864 Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_oxidase; pfam01243 114615000865 Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885 114615000866 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 114615000867 ligand binding site [chemical binding]; other site 114615000868 argininosuccinate synthase; Provisional; Region: PRK13820 114615000869 Argininosuccinate synthase. The Argininosuccinate synthase is a urea cycle enzyme that catalyzes the penultimate step in arginine biosynthesis: the ATP-dependent ligation of citrulline to aspartate to form argininosuccinate, AMP and pyrophosphate . In...; Region: Argininosuccinate_Synthase; cd01999 114615000870 ANP binding site [chemical binding]; other site 114615000871 Substrate Binding Site II [chemical binding]; other site 114615000872 Substrate Binding Site I [chemical binding]; other site 114615000873 PAP2_like_6 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which mainly contains bacterial proteins, lacks functional characterization and may act as a membrane-associated lipid phosphatase; Region: PAP2_like_6; cd03396 114615000874 active site 114615000875 Predicted Fe-S-cluster redox enzyme [General function prediction only]; Region: COG0820 114615000876 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 114615000877 FeS/SAM binding site; other site 114615000878 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 114615000879 Quinone oxidoreductase (QOR); Region: QOR1; cd08241 114615000880 NAD(P) binding site [chemical binding]; other site 114615000881 TRAP transporter solute receptor, TAXI family; Region: TRAP_TAXI; TIGR02122 114615000882 TRAP-type uncharacterized transport system, periplasmic component [General function prediction only]; Region: Imp; COG2358 114615000883 Uncharacterized conserved protein [Function unknown]; Region: COG3339 114615000884 PCD_DCoH: The bifunctional protein pterin-4alpha-carbinolamine dehydratase (PCD), also known as DCoH (dimerization cofactor of hepatocyte nuclear factor-1), is both a transcription activator and a metabolic enzyme. DCoH stimulates gene expression by...; Region: PCD_DCoH_subfamily_b; cd00914 114615000885 aromatic arch; other site 114615000886 DCoH dimer interaction site [polypeptide binding]; other site 114615000887 DCoH /HNF-1 dimer interaction site [polypeptide binding]; other site 114615000888 DCoH tetramer interaction site [polypeptide binding]; other site 114615000889 substrate binding site [chemical binding]; other site 114615000890 TRAP transporter solute receptor, TAXI family; Region: TRAP_TAXI; TIGR02122 114615000891 Phosphodiesterase/alkaline phosphatase D [Inorganic ion transport and metabolism]; Region: PhoD; COG3540 114615000892 Bacillus subtilis PhoD and related proteins, metallophosphatase domain; Region: MPP_PhoD; cd07389 114615000893 putative active site [active] 114615000894 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 114615000895 Response regulator receiver domain; Region: Response_reg; pfam00072 114615000896 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 114615000897 active site 114615000898 phosphorylation site [posttranslational modification] 114615000899 intermolecular recognition site; other site 114615000900 dimerization interface [polypeptide binding]; other site 114615000901 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 114615000902 Crp-like helix-turn-helix domain; Region: HTH_Crp_2; pfam13545 114615000903 Prolipoprotein diacylglyceryl transferase; Region: LGT; cl00478 114615000904 Predicted Fe-S oxidoreductases [General function prediction only]; Region: COG1964 114615000905 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 114615000906 FeS/SAM binding site; other site 114615000907 Predicted membrane GTPase involved in stress response [Signal transduction mechanisms]; Region: TypA; COG1217 114615000908 Tyrosine phosphorylated protein A (TypA)/BipA family belongs to ribosome-binding GTPases; Region: TypA_BipA; cd01891 114615000909 G1 box; other site 114615000910 putative GEF interaction site [polypeptide binding]; other site 114615000911 GTP/Mg2+ binding site [chemical binding]; other site 114615000912 Switch I region; other site 114615000913 G2 box; other site 114615000914 G3 box; other site 114615000915 Switch II region; other site 114615000916 G4 box; other site 114615000917 G5 box; other site 114615000918 BipA_TypA_II: domain II of BipA (also called TypA) having homology to domain II of the elongation factors (EFs) EF-G and EF-Tu. BipA is a highly conserved protein with global regulatory properties in Escherichia coli. BipA is phosphorylated on a...; Region: BipA_TypA_II; cd03691 114615000919 BipA_TypA_C: a C-terminal portion of BipA or TypA having homology to the C terminal domains of the elongation factors EF-G and EF-2. A member of the ribosome binding GTPase superfamily, BipA is widely distributed in bacteria and plants. BipA is a highly...; Region: BipA_TypA_C; cd03710 114615000920 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 114615000921 Flavin containing amine oxidoreductase; Region: Amino_oxidase; pfam01593 114615000922 putative DNA-binding transcriptional regulator; Provisional; Region: PRK10837 114615000923 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 114615000924 C-terminal substrate binding domain of LysR-type transcriptional regulator CysL, which activates the transcription of the cysJI operon encoding sulfite reductase, contains the type 2 periplasmic binding fold; Region: PBP2_CysL_like; cd08420 114615000925 putative dimerization interface [polypeptide binding]; other site 114615000926 Predicted membrane protein [Function unknown]; Region: COG2855 114615000927 Predicted thiol-disulfide oxidoreductase [General function prediction only]; Region: COG3011 114615000928 Predicted nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG0702 114615000929 NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, subunit 9, 39 kDa, (NDUFA9) -like, atypical (a) SDRs; Region: NDUFA9_like_SDR_a; cd05271 114615000930 putative NAD(P) binding site [chemical binding]; other site 114615000931 active site 114615000932 DoxX-like family; Region: DoxX_3; pfam13781 114615000933 Predicted integral membrane protein (DUF2269); Region: DUF2269; pfam10027 114615000934 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 114615000935 Coenzyme A binding pocket [chemical binding]; other site 114615000936 Inorganic pyrophosphatase. These enzymes hydrolyze inorganic pyrophosphate (PPi) to two molecules of orthophosphates (Pi). The reaction requires bivalent cations. The enzymes in general exist as homooligomers; Region: pyrophosphatase; cd00412 114615000937 dimer interface [polypeptide binding]; other site 114615000938 substrate binding site [chemical binding]; other site 114615000939 metal binding sites [ion binding]; metal-binding site 114615000940 hypothetical protein; Provisional; Region: PRK08262 114615000941 M20 Peptidase, carboxypeptidase yscS; Region: M20_yscS; cd05674 114615000942 metal binding site [ion binding]; metal-binding site 114615000943 bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate cyclohydrolase; Provisional; Region: PRK14188 114615000944 Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain; Region: THF_DHG_CYH; pfam00763 114615000945 NADP binding domain of methylene-tetrahydrofolate dehydrogenase/cyclohydrolase; Region: NAD_bind_m-THF_DH_Cyclohyd; cd01080 114615000946 homodimer interface [polypeptide binding]; other site 114615000947 NADP binding site [chemical binding]; other site 114615000948 substrate binding site [chemical binding]; other site 114615000949 hypothetical protein; Validated; Region: PRK01310 114615000950 YGGT family; Region: YGGT; pfam02325 114615000951 GMP synthase - Glutamine amidotransferase domain [Nucleotide transport and metabolism]; Region: GuaA; COG0518 114615000952 Subgroup of proteins having the Type 1 glutamine amidotransferase (GATase1) domain; Region: GATase1_1; cd01741 114615000953 catalytic triad [active] 114615000954 Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300 114615000955 classical (c) SDRs; Region: SDR_c; cd05233 114615000956 NAD(P) binding site [chemical binding]; other site 114615000957 active site 114615000958 tellurium resistance terB-like protein, subgroup 2; Region: terB_like_2; cd07313 114615000959 putative metal binding site [ion binding]; other site 114615000960 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 114615000961 Cytochrome P450; Region: p450; cl12078 114615000962 Lipase (class 2); Region: Lipase_2; pfam01674 114615000963 alpha/beta hydrolase fold; Region: Abhydrolase_1; pfam00561 114615000964 Transmembrane secretion effector; Region: MFS_3; pfam05977 114615000965 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 114615000966 Cysteine rich repeat; Region: Cys_rich_FGFR; pfam00839 114615000967 Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726 114615000968 Catalytic NodB homology domain of rhizobial NodB-like proteins; Region: CE4_NodB_like_6s_7s; cd10917 114615000969 NodB motif; other site 114615000970 active site 114615000971 catalytic site [active] 114615000972 metal binding site [ion binding]; metal-binding site 114615000973 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 114615000974 TPR motif; other site 114615000975 binding surface 114615000976 GSCFA family; Region: GSCFA; pfam08885 114615000977 Transposase; Region: HTH_Tnp_1; pfam01527 114615000978 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 114615000979 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436 114615000980 IS66 Orf2 like protein; Region: TnpB_IS66; pfam05717 114615000981 putative Helix-turn-helix domain of transposase IS66; Region: HTH_Tnp_IS66; pfam13005 114615000982 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436 114615000983 Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050 114615000984 IS66 C-terminal element; Region: DDE_Tnp_IS66_C; pfam13817 114615000985 Phage protein Gp37/Gp68; Region: Gp37_Gp68; cl15384 114615000986 Uncharacterized membrane-bound protein [Function unknown]; Region: COG3898 114615000987 HemY protein N-terminus; Region: HemY_N; pfam07219 114615000988 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4223 114615000989 Uroporphyrinogen-III synthase [Coenzyme metabolism]; Region: HemD; COG1587 114615000990 Uroporphyrinogen-III synthase (HemD) catalyzes the asymmetrical cyclization of tetrapyrrole (linear) to uroporphyrinogen-III, the fourth step in the biosynthesis of heme. This ubiquitous enzyme is present in eukaryotes, bacteria and archaea. Mutations in...; Region: HemD; cd06578 114615000991 active site 114615000992 UGMP family protein; Validated; Region: PRK09604 114615000993 Inactive homolog of metal-dependent proteases, putative molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: COG1214; cl17884 114615000994 FGGY family of carbohydrate kinases, C-terminal domain; Region: FGGY_C; pfam02782 114615000995 NAD(P)H-dependent glycerol-3-phosphate dehydrogenase; Validated; Region: gpsA; PRK00094 114615000996 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210 114615000997 NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus; Region: NAD_Gly3P_dh_C; pfam07479 114615000998 EVE domain; Region: EVE; pfam01878 114615000999 Ammonia permease [Inorganic ion transport and metabolism]; Region: AmtB; COG0004 114615001000 Nitrogen regulatory protein P-II; Region: P-II; pfam00543 114615001001 Nitrogen regulatory protein P-II; Region: P-II; smart00938 114615001002 Ammonia permease [Inorganic ion transport and metabolism]; Region: AmtB; COG0004 114615001003 Nitrogen regulatory protein PII [Amino acid transport and metabolism]; Region: GlnK; COG0347 114615001004 Nitrogen regulatory protein P-II; Region: P-II; smart00938 114615001005 Domain of unknown function (DUF4339); Region: DUF4339; pfam14237 114615001006 Acyl-CoA thioesterase [Lipid metabolism]; Region: TesB; COG1946 114615001007 Thioesterase II (TEII) is thought to regenerate misprimed nonribosomal peptide synthetases (NRPSs) as well as modular polyketide synthases (PKSs) by hydrolyzing acetyl groups bound to the peptidyl carrier protein (PCP) and acyl carrier protein (ACP)...; Region: Thioesterase_II_repeat2; cd03445 114615001008 active site 114615001009 Thioesterase II (TEII) is thought to regenerate misprimed nonribosomal peptide synthetases (NRPSs) as well as modular polyketide synthases (PKSs) by hydrolyzing acetyl groups bound to the peptidyl carrier protein (PCP) and acyl carrier protein (ACP)...; Region: Thioesterase_II_repeat1; cd03444 114615001010 catalytic triad [active] 114615001011 dimer interface [polypeptide binding]; other site 114615001012 2-octaprenyl-6-methoxyphenyl hydroxylase; Provisional; Region: PRK07333 114615001013 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 114615001014 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 114615001015 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 114615001016 Uncharacterized conserved protein [Function unknown]; Region: COG2835 114615001017 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 114615001018 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 114615001019 Cupredoxin-like domain; Region: Cupredoxin_1; pfam13473 114615001020 Iron permease FTR1 family; Region: FTR1; cl00475 114615001021 Uncharacterized protein, similar to the N-terminal domain of Lon protease [General function prediction only]; Region: COG2802 114615001022 Thioredoxin domain-containing protein [Posttranslational modification, protein turnover, chaperones]; Region: COG3118 114615001023 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 114615001024 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 114615001025 binding surface 114615001026 TPR motif; other site 114615001027 Caspase domain; Region: Peptidase_C14; pfam00656 114615001028 Nicotinic acid phosphoribosyltransferase [Coenzyme metabolism]; Region: PncB; COG1488 114615001029 nicotinate phosphoribosyltransferase; Provisional; Region: PRK05321 114615001030 active site 114615001031 Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154 114615001032 Amidase; Region: Amidase; cl11426 114615001033 Glucose/sorbosone dehydrogenases [Carbohydrate transport and metabolism]; Region: COG2133 114615001034 Cytochrome c553 [Energy production and conversion]; Region: COG2863 114615001035 Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010 114615001036 Cytochrome c; Region: Cytochrom_C; cl11414 114615001037 2-dehydropantoate 2-reductase; Provisional; Region: PRK12921 114615001038 Ketopantoate reductase PanE/ApbA; Region: ApbA; pfam02558 114615001039 Ketopantoate reductase PanE/ApbA C terminal; Region: ApbA_C; pfam08546 114615001040 Short-chain alcohol dehydrogenase of unknown specificity [General function prediction only]; Region: COG4221 114615001041 classical (c) SDR, subgroup 10; Region: SDR_c10; cd05373 114615001042 putative NAD(P) binding site [chemical binding]; other site 114615001043 active site 114615001044 Helix-turn-helix domain; Region: HTH_28; pfam13518 114615001045 Winged helix-turn helix; Region: HTH_29; pfam13551 114615001046 Homeodomain-like domain; Region: HTH_32; pfam13565 114615001047 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: Tra5; COG2801 114615001048 Integrase core domain; Region: rve; pfam00665 114615001049 Integrase core domain; Region: rve_3; pfam13683 114615001050 2-hydroxychromene-2-carboxylate isomerase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: NahD; COG3917 114615001051 DsbA family, 2-hydroxychromene-2-carboxylate (HCCA) isomerase subfamily; HCCA isomerase is a glutathione (GSH) dependent enzyme involved in the naphthalene catabolic pathway. It converts HCCA, a hemiketal formed spontaneously after ring cleavage of 1; Region: DsbA_HCCA_Iso; cd03022 114615001052 putative catalytic residue [active] 114615001053 Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534 114615001054 Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Bacillus subtilis yoeA; Region: MATE_yoeA_like; cd13138 114615001055 Uncharacterized protein conserved in bacteria (DUF2239); Region: DUF2239; pfam09998 114615001056 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 114615001057 GST_N family, Saccharomyces cerevisiae GTT1-like subfamily; composed of predominantly uncharacterized proteins with similarity to the S. cerevisiae GST protein, GTT1, and the Schizosaccharomyces pombe GST-III. GSTs are cytosolic dimeric proteins involved...; Region: GST_N_GTT1_like; cd03046 114615001058 putative C-terminal domain interface [polypeptide binding]; other site 114615001059 putative GSH binding site (G-site) [chemical binding]; other site 114615001060 putative dimer interface [polypeptide binding]; other site 114615001061 C-terminal, alpha helical domain of GTT1-like Glutathione S-transferases; Region: GST_C_GTT1_like; cd03189 114615001062 putative N-terminal domain interface [polypeptide binding]; other site 114615001063 putative dimer interface [polypeptide binding]; other site 114615001064 putative substrate binding pocket (H-site) [chemical binding]; other site 114615001065 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 114615001066 Beta-lactamase; Region: Beta-lactamase; pfam00144 114615001067 Gamma-glutamyltransferase [Amino acid transport and metabolism]; Region: Ggt; COG0405 114615001068 Gamma-glutamyltranspeptidase; Region: G_glu_transpept; pfam01019 114615001069 Permeases of the major facilitator superfamily [General function prediction only]; Region: COG2270 114615001070 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 114615001071 putative substrate translocation pore; other site 114615001072 bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; Provisional; Region: purH; PRK00881 114615001073 Inosine monophosphate cyclohydrolase domain. This is the N-terminal domain in the purine biosynthesis pathway protein ATIC (purH). The bifunctional ATIC protein contains a C-terminal ATIC formylase domain that formylates...; Region: IMPCH; cd01421 114615001074 purine monophosphate binding site [chemical binding]; other site 114615001075 dimer interface [polypeptide binding]; other site 114615001076 putative catalytic residues [active] 114615001077 AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; smart00798 114615001078 AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; cl03362 114615001079 Heparinase II/III-like protein; Region: Hepar_II_III; cl15421 114615001080 RNA binding domain of NusB (N protein-Utilization Substance B) and Sun (also known as RrmB or Fmu) proteins. This family includes two orthologous groups exemplified by the transcription termination factor NusB and the N-terminal domain of the...; Region: NusB_Sun; cl00223 114615001081 putative RNA binding site [nucleotide binding]; other site 114615001082 tRNA and rRNA cytosine-C5-methylases [Translation, ribosomal structure and biogenesis]; Region: Sun; COG0144 114615001083 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 114615001084 S-adenosylmethionine binding site [chemical binding]; other site 114615001085 Uncharacterized conserved small protein [Function unknown]; Region: COG5508 114615001086 Protein of unknown function (DUF1674); Region: DUF1674; pfam07896 114615001087 Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376 114615001088 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 114615001089 acetyl-CoA synthetase; Provisional; Region: PRK00174 114615001090 Acetyl-CoA synthetase (also known as acetate-CoA ligase and acetyl-activating enzyme); Region: ACS; cd05966 114615001091 active site 114615001092 CoA binding site [chemical binding]; other site 114615001093 acyl-activating enzyme (AAE) consensus motif; other site 114615001094 AMP binding site [chemical binding]; other site 114615001095 acetate binding site [chemical binding]; other site 114615001096 Topoisomerase IB [DNA replication, recombination, and repair]; Region: COG3569 114615001097 DNA topoisomerase IB, C-terminal catalytic domain. Topoisomerase I promotes the relaxation of both positive and negative DNA superhelical tension by introducing a transient single-stranded break in duplex DNA. This function is vital for the processes of...; Region: Topo_IB_C; cd00659 114615001098 active site 114615001099 DNA binding site [nucleotide binding] 114615001100 Int/Topo IB signature motif; other site 114615001101 catalytic residues [active] 114615001102 Secreted and surface protein containing fasciclin-like repeats [Cell envelope biogenesis, outer membrane]; Region: COG2335 114615001103 Fasciclin domain; Region: Fasciclin; pfam02469 114615001104 Cytochrome b(N-terminal)/b6/petB; Region: Cytochrom_B_N; pfam00033 114615001105 Sulfite oxidase and related enzymes [General function prediction only]; Region: COG2041 114615001106 bacterial subgroup of the sulfite oxidase (SO) family of molybdopterin binding domains. This domain is found in a variety of oxidoreductases. Common features of all known members of this family, like sulfite oxidase and nitrite reductase, are that they...; Region: bact_SO_family_Moco; cd02108 114615001107 Moco binding site; other site 114615001108 metal coordination site [ion binding]; other site 114615001109 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 114615001110 putative substrate translocation pore; other site 114615001111 Major Facilitator Superfamily; Region: MFS_1; pfam07690 114615001112 tartrate dehydrogenase; Region: TTC; TIGR02089 114615001113 3-isopropylmalate dehydrogenase; Provisional; Region: PRK00772 114615001114 aspartate-semialdehyde dehydrogenase; Provisional; Region: PRK14874 114615001115 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 114615001116 hypothetical protein; Provisional; Region: PRK05208 114615001117 Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA_cladeB; cd00884 114615001118 active site clefts [active] 114615001119 zinc binding site [ion binding]; other site 114615001120 dimer interface [polypeptide binding]; other site 114615001121 Citrate lyase beta subunit [Carbohydrate transport and metabolism]; Region: CitE; COG2301 114615001122 Cytochrome c; Region: Cytochrom_C; pfam00034 114615001123 isopropylmalate isomerase small subunit; Provisional; Region: leuD; PRK01641 114615001124 Aconatase-like swivel domain of 3-isopropylmalate dehydratase and related uncharacterized proteins. 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate...; Region: IPMI_Swivel; cd01577 114615001125 substrate binding site [chemical binding]; other site 114615001126 Minimal MMP-like domain found in Acidothermus cellulolyticus hypothetical protein ACEL2062 and similar protein; Region: MMP_ACEL2062; cd12952 114615001127 3-isopropylmalate dehydratase large subunit; Reviewed; Region: PRK00402 114615001128 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate; Region: IPMI; cd01583 114615001129 substrate binding site [chemical binding]; other site 114615001130 ligand binding site [chemical binding]; other site 114615001131 50S ribosomal protein L19; Provisional; Region: rplS; PRK05338 114615001132 tRNA (guanine-N(1)-)-methyltransferase; Reviewed; Region: trmD; PRK00026 114615001133 RimM N-terminal domain; Region: RimM; pfam01782 114615001134 16S rRNA-processing protein RimM; Provisional; Region: rimM; PRK13828 114615001135 PRC-barrel domain; Region: PRC; pfam05239 114615001136 30S ribosomal protein S16; Reviewed; Region: rpsP; PRK00040 114615001137 signal recognition particle protein; Provisional; Region: PRK10867 114615001138 SRP54-type protein, helical bundle domain; Region: SRP54_N; smart00963 114615001139 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115 114615001140 P loop; other site 114615001141 GTP binding site [chemical binding]; other site 114615001142 Signal peptide binding domain; Region: SRP_SPB; pfam02978 114615001143 Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220 114615001144 Beta-lactamase superfamily domain; Region: Lactamase_B_2; pfam12706 114615001145 Uncharacterized conserved protein [Function unknown]; Region: COG2968 114615001146 Protein of unknown function (DUF541); Region: SIMPL; pfam04402 114615001147 Bacterial transcription activator, effector binding domain; Region: AraC_E_bind; smart00871 114615001148 diaminopimelate epimerase; Provisional; Region: dapF; PRK00450 114615001149 Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678 114615001150 Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678 114615001151 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 114615001152 MiaB-like tRNA modifying enzyme; Region: MiaB-like-C; TIGR01579 114615001153 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 114615001154 FeS/SAM binding site; other site 114615001155 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 114615001156 active site 114615001157 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 114615001158 signal recognition particle-docking protein FtsY; Provisional; Region: PRK10416 114615001159 SRP54-type protein, helical bundle domain; Region: SRP54_N; pfam02881 114615001160 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115 114615001161 P loop; other site 114615001162 GTP binding site [chemical binding]; other site 114615001163 intracellular septation protein A; Reviewed; Region: PRK00259 114615001164 TlpA-like family, DsbE (also known as CcmG and CycY) subfamily; DsbE is a membrane-anchored, periplasmic TRX-like reductase containing a CXXC motif that specifically donates reducing equivalents to apocytochrome c via CcmH, another cytochrome c...; Region: TlpA_like_DsbE; cd03010 114615001165 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 114615001166 catalytic residues [active] 114615001167 central insert; other site 114615001168 heme exporter protein CcmC; Region: ccmC; TIGR01191 114615001169 heme exporter protein CcmB; Region: ccmB; TIGR01190 114615001170 cytochrome c biogenesis protein CcmA; Provisional; Region: PRK13539 114615001171 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 114615001172 Walker A/P-loop; other site 114615001173 ATP binding site [chemical binding]; other site 114615001174 Q-loop/lid; other site 114615001175 ABC transporter signature motif; other site 114615001176 Walker B; other site 114615001177 D-loop; other site 114615001178 H-loop/switch region; other site 114615001179 aconitate hydratase; Validated; Region: PRK09277 114615001180 Aconitase A catalytic domain; Region: AcnA_IRP; cd01586 114615001181 substrate binding site [chemical binding]; other site 114615001182 ligand binding site [chemical binding]; other site 114615001183 Aconitase A swivel domain. This is the major form of the TCA cycle enzyme aconitate hydratase, also known as aconitase and citrate hydro-lyase. It includes bacterial and archaeal aconitase A, and the eukaryotic cytosolic form of aconitase. This group...; Region: AcnA_IRP_Swivel; cd01580 114615001184 substrate binding site [chemical binding]; other site 114615001185 Protein of unknown function (DUF1223); Region: DUF1223; pfam06764 114615001186 Protein of unknown function (DUF2794); Region: DUF2794; pfam10984 114615001187 Sortase and related acyltransferases [Cell envelope biogenesis, outer membrane]; Region: COG1247 114615001188 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 114615001189 Coenzyme A binding pocket [chemical binding]; other site 114615001190 Integral membrane protein, interacts with FtsH [General function prediction only]; Region: COG0670 114615001191 Bacterial BAX inhibitor (BI)-1/YccA-like proteins; Region: BI-1-like_bacterial; cd10432 114615001192 Predicted ABC-type transport system involved in lysophospholipase L1 biosynthesis, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3127 114615001193 FtsX-like permease family; Region: FtsX; pfam02687 114615001194 Predicted ABC-type transport system involved in lysophospholipase L1 biosynthesis, ATPase component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG4181 114615001195 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 114615001196 Walker A/P-loop; other site 114615001197 ATP binding site [chemical binding]; other site 114615001198 Q-loop/lid; other site 114615001199 ABC transporter signature motif; other site 114615001200 Walker B; other site 114615001201 D-loop; other site 114615001202 H-loop/switch region; other site 114615001203 Lysophospholipase L1-like subgroup of SGNH-hydrolases. The best characterized member in this family is TesA, an E. coli periplasmic protein with thioesterase, esterase, arylesterase, protease and lysophospholipase activity; Region: Lysophospholipase_L1_like; cd01822 114615001204 active site 114615001205 oxyanion hole [active] 114615001206 switch loop; other site 114615001207 catalytic triad [active] 114615001208 2'-5' RNA ligase; Region: 2_5_ligase; TIGR02258 114615001209 LigT like Phosphoesterase; Region: LigT_PEase; pfam02834 114615001210 LigT like Phosphoesterase; Region: LigT_PEase; pfam02834 114615001211 AFG1-like ATPase; Region: AFG1_ATPase; pfam03969 114615001212 malate dehydrogenase; Reviewed; Region: PRK06223 114615001213 L-lactate dehydrogenase-like malate dehydrogenase proteins; Region: LDH-like_MDH; cd01339 114615001214 NAD(P) binding site [chemical binding]; other site 114615001215 dimer interface [polypeptide binding]; other site 114615001216 tetramer (dimer of dimers) interface [polypeptide binding]; other site 114615001217 substrate binding site [chemical binding]; other site 114615001218 succinyl-CoA synthetase subunit beta; Provisional; Region: sucC; PRK00696 114615001219 ATP-grasp domain; Region: ATP-grasp_2; pfam08442 114615001220 CoA-ligase; Region: Ligase_CoA; pfam00549 114615001221 succinyl-CoA synthetase subunit alpha; Validated; Region: PRK05678 114615001222 CoA binding domain; Region: CoA_binding; smart00881 114615001223 CoA-ligase; Region: Ligase_CoA; pfam00549 114615001224 2-oxoglutarate dehydrogenase E1 component; Reviewed; Region: sucA; PRK09404 114615001225 Thiamine pyrophosphate (TPP) family, E1 of OGDC-like subfamily, TPP-binding module; composed of proteins similar to the E1 component of the 2-oxoglutarate dehydrogenase multienzyme complex (OGDC). OGDC catalyzes the oxidative decarboxylation of...; Region: TPP_E1_OGDC_like; cd02016 114615001226 TPP-binding site [chemical binding]; other site 114615001227 Transketolase, pyrimidine binding domain; Region: Transket_pyr; pfam02779 114615001228 dimer interface [polypeptide binding]; other site 114615001229 PYR/PP interface [polypeptide binding]; other site 114615001230 TPP binding site [chemical binding]; other site 114615001231 dihydrolipoamide succinyltransferase; Validated; Region: PRK05704 114615001232 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 114615001233 E3 interaction surface; other site 114615001234 lipoyl attachment site [posttranslational modification]; other site 114615001235 e3 binding domain; Region: E3_binding; pfam02817 114615001236 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 114615001237 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 114615001238 short chain dehydrogenase; Provisional; Region: PRK06123 114615001239 NAD(P) binding site [chemical binding]; other site 114615001240 active site 114615001241 dihydrolipoamide dehydrogenase; Validated; Region: PRK06292 114615001242 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 114615001243 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 114615001244 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 114615001245 Domain of unknown function (DUF4337); Region: DUF4337; pfam14235 114615001246 site-specific tyrosine recombinase XerC; Reviewed; Region: xerC; PRK00236 114615001247 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 114615001248 active site 114615001249 DNA binding site [nucleotide binding] 114615001250 Int/Topo IB signature motif; other site 114615001251 primosome assembly protein PriA; Validated; Region: PRK05580 114615001252 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 114615001253 ATP binding site [chemical binding]; other site 114615001254 putative Mg++ binding site [ion binding]; other site 114615001255 Lipoproteins [Cell envelope biogenesis, outer membrane]; Region: RlpA; COG0797 114615001256 Rare lipoprotein A (RlpA)-like double-psi beta-barrel; Region: DPBB_1; pfam03330 114615001257 F0F1 ATP synthase subunit delta; Validated; Region: PRK05758 114615001258 ATP synthase delta (OSCP) subunit; Region: OSCP; pfam00213 114615001259 F0F1 ATP synthase subunit alpha; Validated; Region: PRK09281 114615001260 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 114615001261 F1 ATP synthase alpha, central domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a proton gradient to...; Region: F1_ATPase_alpha; cd01132 114615001262 beta subunit interaction interface [polypeptide binding]; other site 114615001263 Walker A motif; other site 114615001264 ATP binding site [chemical binding]; other site 114615001265 Walker B motif; other site 114615001266 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 114615001267 mitochondrial ATP synthase gamma subunit; Region: F1-ATPase_gamma; cd12151 114615001268 core domain interface [polypeptide binding]; other site 114615001269 delta subunit interface [polypeptide binding]; other site 114615001270 epsilon subunit interface [polypeptide binding]; other site 114615001271 F0F1 ATP synthase subunit beta; Validated; Region: PRK09280 114615001272 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 114615001273 F1 ATP synthase beta subunit, nucleotide-binding domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a...; Region: F1-ATPase_beta; cd01133 114615001274 alpha subunit interaction interface [polypeptide binding]; other site 114615001275 Walker A motif; other site 114615001276 ATP binding site [chemical binding]; other site 114615001277 Walker B motif; other site 114615001278 inhibitor binding site; inhibition site 114615001279 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 114615001280 F0F1 ATP synthase subunit epsilon; Provisional; Region: atpC; PRK13448 114615001281 mitochondrial ATP synthase delta subunit; Region: F1-ATPase_delta; cd12152 114615001282 gamma subunit interface [polypeptide binding]; other site 114615001283 epsilon subunit interface [polypeptide binding]; other site 114615001284 LBP interface [polypeptide binding]; other site 114615001285 cyclase homology domain; Region: CHD; cd07302 114615001286 Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114 114615001287 nucleotidyl binding site; other site 114615001288 metal binding site [ion binding]; metal-binding site 114615001289 dimer interface [polypeptide binding]; other site 114615001290 Diadenosine tetraphosphate (Ap4A) hydrolase is a member of the Nudix hydrolase superfamily. Members of this family are well represented in a variety of prokaryotic and eukaryotic organisms. Phylogenetic analysis reveals two distinct subgroups where plant...; Region: Ap4A_hydrolase_plant_like; cd03671 114615001291 putative active site [active] 114615001292 Ap4A binding site [chemical binding]; other site 114615001293 nudix motif; other site 114615001294 putative metal binding site [ion binding]; other site 114615001295 Diadenosine tetraphosphate (Ap4A) hydrolase is a member of the Nudix hydrolase superfamily. Members of this family are well represented in a variety of prokaryotic and eukaryotic organisms. Phylogenetic analysis reveals two distinct subgroups where plant...; Region: Ap4A_hydrolase_plant_like; cd03671 114615001296 putative active site [active] 114615001297 Ap4A binding site [chemical binding]; other site 114615001298 nudix motif; other site 114615001299 putative metal binding site [ion binding]; other site 114615001300 Putative catalytic domain of family 2 polysaccharide deacetylases (DACs) from bacteria; Region: CE4_DAC2; cd10936 114615001301 putative active site [active] 114615001302 NodB motif; other site 114615001303 Periplasmic protease [Cell envelope biogenesis, outer membrane]; Region: Prc; COG0793 114615001304 C-terminal processing peptidase family S41; Region: Peptidase_S41; cl02526 114615001305 PDZ domain of C-terminal processing-, tail-specific-, and tricorn proteases, which function in posttranslational protein processing, maturation, and disassembly or degradation, in Bacteria, Archaea, and plant chloroplasts. May be responsible for...; Region: PDZ_CTP_protease; cd00988 114615001306 protein binding site [polypeptide binding]; other site 114615001307 C-terminal processing peptidase; serine protease family S41; Region: Peptidase_S41_CPP; cd07560 114615001308 Catalytic dyad [active] 114615001309 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 114615001310 Peptidase family M23; Region: Peptidase_M23; pfam01551 114615001311 rRNA large subunit methyltransferase; Provisional; Region: PRK00103 114615001312 iojap-like ribosome-associated protein; Region: iojap_ybeB; TIGR00090 114615001313 nicotinic acid mononucleotide adenylyltransferase; Provisional; Region: nadD; PRK00071 114615001314 Nicotinamide/nicotinate mononucleotide adenylyltransferase; Region: NMNAT; cd02165 114615001315 active site 114615001316 (T/H)XGH motif; other site 114615001317 Gamma-glutamyl phosphate reductase (GPR), aldehyde dehydrogenase families 18 and 19; Region: ALDH_F18-19_ProA-GPR; cd07079 114615001318 gamma-glutamyl phosphate reductase; Region: proA; TIGR00407 114615001319 putative catalytic cysteine [active] 114615001320 gamma-glutamyl kinase; Provisional; Region: PRK05429 114615001321 AAK_G5K_ProB: Glutamate-5-kinase (G5K) catalyzes glutamate-dependent ATP cleavage; G5K transfers the terminal phosphoryl group of ATP to the gamma-carboxyl group of glutamate, in the first and controlling step of proline (and, in mammals, ornithine)...; Region: AAK_G5K_ProB; cd04242 114615001322 nucleotide binding site [chemical binding]; other site 114615001323 homotetrameric interface [polypeptide binding]; other site 114615001324 putative phosphate binding site [ion binding]; other site 114615001325 putative allosteric binding site; other site 114615001326 PUA domain; Region: PUA; pfam01472 114615001327 GTPase CgtA; Reviewed; Region: obgE; PRK12299 114615001328 GTP1/OBG; Region: GTP1_OBG; pfam01018 114615001329 Obg GTPase; Region: Obg; cd01898 114615001330 G1 box; other site 114615001331 GTP/Mg2+ binding site [chemical binding]; other site 114615001332 Switch I region; other site 114615001333 G2 box; other site 114615001334 G3 box; other site 114615001335 Switch II region; other site 114615001336 G4 box; other site 114615001337 G5 box; other site 114615001338 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 114615001339 Putative exonuclease, RdgC; Region: RdgC; cl01122 114615001340 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 114615001341 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 114615001342 50S ribosomal protein L27; Validated; Region: rpmA; PRK05435 114615001343 50S ribosomal protein L21/unknown domain fusion protein; Provisional; Region: PRK12278 114615001344 50S ribosomal protein L21; Validated; Region: rplU; PRK05573 114615001345 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 114615001346 nucleotide binding site [chemical binding]; other site 114615001347 Homeodomain-like domain; Region: HTH_23; pfam13384 114615001348 Predicted unusual protein kinase [General function prediction only]; Region: AarF; COG0661 114615001349 ABC1 family; Region: ABC1; cl17513 114615001350 Deoxyribodipyrimidine photolyase [DNA replication, recombination, and repair]; Region: PhrB; COG0415 114615001351 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 114615001352 Predicted NAD/FAD-dependent oxidoreductase [General function prediction only]; Region: COG3380 114615001353 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 114615001354 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 114615001355 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 114615001356 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 114615001357 AP endonuclease family 2 C terminus; Region: AP_endonuc_2_N; pfam07582 114615001358 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 114615001359 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 114615001360 Aerobic-type carbon monoxide dehydrogenase, small subunit CoxS/CutS homologs [Energy production and conversion]; Region: CoxS; COG2080 114615001361 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 114615001362 catalytic loop [active] 114615001363 iron binding site [ion binding]; other site 114615001364 [2Fe-2S] binding domain; Region: Fer2_2; pfam01799 114615001365 Aerobic-type carbon monoxide dehydrogenase, large subunit CoxL/CutL homologs [Energy production and conversion]; Region: CoxL; COG1529 114615001366 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 114615001367 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; smart01008 114615001368 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 114615001369 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 114615001370 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 114615001371 Transcriptional regulator containing an amidase domain and an AraC-type DNA-binding HTH domain [Transcription]; Region: COG4977 114615001372 AraC transcriptional regulators having a Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GATase1_AraC_1; cd03137 114615001373 conserved cys residue [active] 114615001374 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 114615001375 Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300 114615001376 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 114615001377 NAD(P) binding site [chemical binding]; other site 114615001378 active site 114615001379 HNH endonuclease; Region: HNH_2; pfam13391 114615001380 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 114615001381 active site 114615001382 DNA binding site [nucleotide binding] 114615001383 Int/Topo IB signature motif; other site 114615001384 Superfamily of nucleases including Short Patch Repair (Vsr) Endonucleases, archaeal Holliday junction resolvases, MutH methy-directed DNA mismatch-repair endonucleases, and catalytic domains of many restriction endonucleases, such as EcoRI, BamHI, and...; Region: Restriction_endonuclease_like; cl00277 114615001385 putative active site [active] 114615001386 TSCPD domain; Region: TSCPD; cl14834 114615001387 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 114615001388 Walker A motif; other site 114615001389 ATP binding site [chemical binding]; other site 114615001390 Walker B motif; other site 114615001391 ribbon-helix-helix domain containing protein; Region: PHA00617 114615001392 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 114615001393 non-specific DNA binding site [nucleotide binding]; other site 114615001394 salt bridge; other site 114615001395 sequence-specific DNA binding site [nucleotide binding]; other site 114615001396 HNH endonuclease; Region: HNH; pfam01844 114615001397 Restriction endonuclease [Defense mechanisms]; Region: McrA; COG1403 114615001398 active site 114615001399 Uncharacterized conserved protein [Function unknown]; Region: COG2135 114615001400 methyltransferase, FkbM family; Region: fkbM_fam; TIGR01444 114615001401 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 114615001402 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 114615001403 active site 114615001404 catalytic tetrad [active] 114615001405 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961 114615001406 Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cd00338 114615001407 catalytic residues [active] 114615001408 catalytic nucleophile [active] 114615001409 Recombinase; Region: Recombinase; pfam07508 114615001410 Uncharacterized ACR, COG2135; Region: DUF159; cl03646 114615001411 hypothetical protein; Provisional; Region: PRK11770 114615001412 Domain of unknown function (DUF307); Region: DUF307; pfam03733 114615001413 Domain of unknown function (DUF307); Region: DUF307; pfam03733 114615001414 PAS fold; Region: PAS_7; pfam12860 114615001415 PAS fold; Region: PAS_4; pfam08448 114615001416 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 114615001417 putative active site [active] 114615001418 heme pocket [chemical binding]; other site 114615001419 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 114615001420 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 114615001421 metal binding site [ion binding]; metal-binding site 114615001422 active site 114615001423 I-site; other site 114615001424 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 114615001425 ABC-type branched-chain amino acid transport system, permease component [Amino acid transport and metabolism]; Region: LivM; COG4177 114615001426 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 114615001427 TM-ABC transporter signature motif; other site 114615001428 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 114615001429 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 114615001430 TM-ABC transporter signature motif; other site 114615001431 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410 114615001432 ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224 114615001433 Walker A/P-loop; other site 114615001434 ATP binding site [chemical binding]; other site 114615001435 Q-loop/lid; other site 114615001436 ABC transporter signature motif; other site 114615001437 Walker B; other site 114615001438 D-loop; other site 114615001439 H-loop/switch region; other site 114615001440 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411 114615001441 ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219 114615001442 Walker A/P-loop; other site 114615001443 ATP binding site [chemical binding]; other site 114615001444 Q-loop/lid; other site 114615001445 ABC transporter signature motif; other site 114615001446 Walker B; other site 114615001447 D-loop; other site 114615001448 H-loop/switch region; other site 114615001449 Periplasmic binding protein; Region: Peripla_BP_6; pfam13458 114615001450 Periplasmic solute-binding domain of active transport proteins found in gram-negative and gram-positive bacteria; Region: PBP1_SBP_like_2; cd06328 114615001451 putative ligand binding site [chemical binding]; other site 114615001452 PAS domain S-box; Region: sensory_box; TIGR00229 114615001453 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 114615001454 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 114615001455 metal binding site [ion binding]; metal-binding site 114615001456 active site 114615001457 I-site; other site 114615001458 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 114615001459 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920 114615001460 HWE histidine kinase; Region: HWE_HK; smart00911 114615001461 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 114615001462 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK07231 114615001463 NAD(P) binding site [chemical binding]; other site 114615001464 active site 114615001465 Cytochrome P450; Region: p450; cl12078 114615001466 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 114615001467 Response regulator receiver domain; Region: Response_reg; pfam00072 114615001468 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 114615001469 active site 114615001470 phosphorylation site [posttranslational modification] 114615001471 intermolecular recognition site; other site 114615001472 dimerization interface [polypeptide binding]; other site 114615001473 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 114615001474 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases [Energy production and conversion]; Region: COG2141 114615001475 esterase, PHB depolymerase family; Region: esterase_phb; TIGR01840 114615001476 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 114615001477 Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491 114615001478 Alpha amylase catalytic domain found in oligo-1,6-glucosidase (also called isomaltase; sucrase-isomaltase; alpha-limit dextrinase) and related proteins; Region: AmyAc_OligoGlu_like; cd11331 114615001479 alpha,alpha-phosphotrehalase; Region: trehalose_treC; TIGR02403 114615001480 active site 114615001481 catalytic site [active] 114615001482 Domain of unknown function (DUF3459); Region: DUF3459; pfam11941 114615001483 trehalose synthase; Region: treS_nterm; TIGR02456 114615001484 Alpha amylase catalytic domain found in Trehalose synthetase; Region: AmyAc_TreS; cd11334 114615001485 active site 114615001486 catalytic site [active] 114615001487 Protein of unknown function (DUF1052); Region: DUF1052; pfam06319 114615001488 Response regulator consisting of a CheY-like receiver domain and a Fis-type HTH domain [Signal transduction mechanisms / Transcription]; Region: COG4567 114615001489 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 114615001490 active site 114615001491 phosphorylation site [posttranslational modification] 114615001492 intermolecular recognition site; other site 114615001493 dimerization interface [polypeptide binding]; other site 114615001494 PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556 114615001495 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 114615001496 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 114615001497 dimer interface [polypeptide binding]; other site 114615001498 phosphorylation site [posttranslational modification] 114615001499 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 114615001500 ATP binding site [chemical binding]; other site 114615001501 Mg2+ binding site [ion binding]; other site 114615001502 G-X-G motif; other site 114615001503 ABC-type Na+ transport system, ATPase component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatA; COG4555 114615001504 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 114615001505 Walker A/P-loop; other site 114615001506 ATP binding site [chemical binding]; other site 114615001507 Q-loop/lid; other site 114615001508 ABC transporter signature motif; other site 114615001509 Walker B; other site 114615001510 D-loop; other site 114615001511 H-loop/switch region; other site 114615001512 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 114615001513 ABC-2 type transporter; Region: ABC2_membrane; cl17235 114615001514 Poly-beta-hydroxyalkanoate depolymerase [Lipid metabolism]; Region: DepA; COG4553 114615001515 PHB de-polymerase C-terminus; Region: PHB_depo_C; pfam06850 114615001516 Protein of unknown function DUF45; Region: DUF45; pfam01863 114615001517 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 114615001518 cyclic-di-GMP phosphodiesterase; Provisional; Region: PRK11359 114615001519 putative active site [active] 114615001520 heme pocket [chemical binding]; other site 114615001521 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 114615001522 putative active site [active] 114615001523 heme pocket [chemical binding]; other site 114615001524 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 114615001525 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 114615001526 metal binding site [ion binding]; metal-binding site 114615001527 active site 114615001528 I-site; other site 114615001529 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 114615001530 Transglycosylase; Region: Transgly; pfam00912 114615001531 penicillin-binding protein, 1A family; Region: PBP_1a_fam; TIGR02074 114615001532 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 114615001533 Protein of unknown function (DUF1330); Region: DUF1330; cl02288 114615001534 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 114615001535 dimerization interface [polypeptide binding]; other site 114615001536 putative DNA binding site [nucleotide binding]; other site 114615001537 putative Zn2+ binding site [ion binding]; other site 114615001538 Putative hydrophobic ligand-binding SRPBCC domain of Micromonospora echinospora CalC, human Aha1, and related proteins; Region: SRPBCC_CalC_Aha1-like; cd07814 114615001539 Protease subunit of ATP-dependent Clp proteases [Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: ClpP; COG0740 114615001540 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017 114615001541 oligomer interface [polypeptide binding]; other site 114615001542 active site residues [active] 114615001543 Type I periplasmic ligand-binding domain of uncharacterized ABC (ATPase Binding Cassette)-type active transport systems that are predicted to be involved in uptake of amino acids, peptides, or inorganic ions; Region: PBP1_ABC_ligand_binding_like_8; cd06343 114615001544 Periplasmic binding protein; Region: Peripla_BP_6; pfam13458 114615001545 putative ligand binding site [chemical binding]; other site 114615001546 Type I periplasmic ligand-binding domain of uncharacterized ABC (ATPase Binding Cassette)-type active transport systems that are predicted to be involved in uptake of amino acids, peptides, or inorganic ions; Region: PBP1_ABC_ligand_binding_like_8; cd06343 114615001547 Periplasmic binding protein; Region: Peripla_BP_6; pfam13458 114615001548 putative ligand binding site [chemical binding]; other site 114615001549 Protein of unknown function (DUF1304); Region: DUF1304; pfam06993 114615001550 PII uridylyl-transferase; Provisional; Region: PRK05092 114615001551 Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401 114615001552 metal binding triad; other site 114615001553 GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335 114615001554 HD domain; Region: HD; pfam01966 114615001555 ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141 114615001556 C-terminal ACT domains of the bacterial signal-transducing uridylyltransferase /uridylyl-removing (UUR) enzyme, GlnD and related domains; Region: ACT_ACR-UUR-like_2; cd04899 114615001557 NMT1/THI5 like; Region: NMT1; pfam09084 114615001558 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 114615001559 substrate binding pocket [chemical binding]; other site 114615001560 membrane-bound complex binding site; other site 114615001561 hinge residues; other site 114615001562 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 114615001563 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 114615001564 dimer interface [polypeptide binding]; other site 114615001565 conserved gate region; other site 114615001566 putative PBP binding loops; other site 114615001567 ABC-ATPase subunit interface; other site 114615001568 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 114615001569 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 114615001570 Walker A/P-loop; other site 114615001571 ATP binding site [chemical binding]; other site 114615001572 Q-loop/lid; other site 114615001573 ABC transporter signature motif; other site 114615001574 Walker B; other site 114615001575 D-loop; other site 114615001576 H-loop/switch region; other site 114615001577 OsmC-like protein; Region: OsmC; pfam02566 114615001578 TIGR02594 family protein; Region: TIGR02594 114615001579 DNA mismatch repair protein MutS; Provisional; Region: PRK05399 114615001580 MutS domain I; Region: MutS_I; pfam01624 114615001581 MutS domain II; Region: MutS_II; pfam05188 114615001582 MutS domain III; Region: MutS_III; pfam05192 114615001583 ATP-binding cassette domain of MutS1 homolog; Region: ABC_MutS1; cd03284 114615001584 Walker A/P-loop; other site 114615001585 ATP binding site [chemical binding]; other site 114615001586 Q-loop/lid; other site 114615001587 ABC transporter signature motif; other site 114615001588 Walker B; other site 114615001589 D-loop; other site 114615001590 H-loop/switch region; other site 114615001591 beta-ketoadipyl CoA thiolase; Validated; Region: PRK09050 114615001592 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 114615001593 dimer interface [polypeptide binding]; other site 114615001594 active site 114615001595 Intradiol dioxygenases catalyze the critical ring-cleavage step in the conversion of catecholate derivatives to citric acid cycle intermediates. This family contains catechol 1,2-dioxygenases and protocatechuate 3,4-dioxygenases which are mononuclear...; Region: intradiol_dioxygenase; cl17208 114615001596 chlorocatechol 1,2-dioxygenase; Region: chlorocat_1_2; TIGR02465 114615001597 active site 114615001598 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 114615001599 Major Facilitator Superfamily; Region: MFS_1; pfam07690 114615001600 putative substrate translocation pore; other site 114615001601 Multidrug resistance efflux pump [Defense mechanisms]; Region: EmrA; COG1566 114615001602 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 114615001603 HlyD family secretion protein; Region: HlyD_3; pfam13437 114615001604 Transcriptional regulators [Transcription]; Region: MarR; COG1846 114615001605 MarR family; Region: MarR; pfam01047 114615001606 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 114615001607 metal binding site 2 [ion binding]; metal-binding site 114615001608 putative DNA binding helix; other site 114615001609 metal binding site 1 [ion binding]; metal-binding site 114615001610 dimer interface [polypeptide binding]; other site 114615001611 structural Zn2+ binding site [ion binding]; other site 114615001612 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 114615001613 EamA-like transporter family; Region: EamA; pfam00892 114615001614 EamA-like transporter family; Region: EamA; pfam00892 114615001615 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Reviewed; Region: ispG; PRK00366 114615001616 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694 114615001617 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694 114615001618 NB-ARC domain; Region: NB-ARC; pfam00931 114615001619 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 114615001620 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 114615001621 Coenzyme A binding pocket [chemical binding]; other site 114615001622 Plasmid stabilisation system protein; Region: Plasmid_stabil; pfam05016 114615001623 Na+/H+ antiporter, bacterial form; Region: a_cpa1; TIGR00831 114615001624 Putative lumazine-binding; Region: Lumazine_bd_2; pfam12893 114615001625 Caspase domain; Region: Peptidase_C14; pfam00656 114615001626 Protein of unknown function (DUF1345); Region: DUF1345; pfam07077 114615001627 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 114615001628 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 114615001629 substrate binding pocket [chemical binding]; other site 114615001630 chain length determination region; other site 114615001631 substrate-Mg2+ binding site; other site 114615001632 catalytic residues [active] 114615001633 aspartate-rich region 1; other site 114615001634 active site lid residues [active] 114615001635 aspartate-rich region 2; other site 114615001636 monofunctional biosynthetic peptidoglycan transglycosylase; Provisional; Region: mtgA; PRK00056 114615001637 Transglycosylase; Region: Transgly; cl17702 114615001638 Ribosomal protein L32 [Translation, ribosomal structure and biogenesis]; Region: RpmF; COG0333 114615001639 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 114615001640 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 114615001641 metal binding site [ion binding]; metal-binding site 114615001642 active site 114615001643 I-site; other site 114615001644 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 114615001645 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5394 114615001646 PHB/PHA accumulation regulator DNA-binding domain; Region: PHB_acc_N; pfam07879 114615001647 PHB accumulation regulatory domain; Region: PHB_acc; pfam05233 114615001648 putative acyltransferase; Provisional; Region: PRK05790 114615001649 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 114615001650 dimer interface [polypeptide binding]; other site 114615001651 active site 114615001652 acetoacetyl-CoA reductase; Region: AcAcCoA_reduct; TIGR01829 114615001653 beta-Keto acyl carrier protein reductase (BKR), involved in Type II FAS, classical (c) SDRs; Region: BKR_SDR_c; cd05333 114615001654 NAD(P) binding site [chemical binding]; other site 114615001655 homotetramer interface [polypeptide binding]; other site 114615001656 homodimer interface [polypeptide binding]; other site 114615001657 active site 114615001658 aromatic amino acid exporter; Provisional; Region: PRK11689 114615001659 EamA-like transporter family; Region: EamA; pfam00892 114615001660 Predicted signal transduction protein containing a membrane domain, an EAL and a GGDEF domain [Signal transduction mechanisms]; Region: COG5001 114615001661 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 114615001662 metal binding site [ion binding]; metal-binding site 114615001663 active site 114615001664 I-site; other site 114615001665 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 114615001666 Cupin superfamily (DUF985); Region: Cupin_5; cl01418 114615001667 hydroxyacylglutathione hydrolase; Region: GSH_gloB; TIGR03413 114615001668 Methyltransferase domain; Region: Methyltransf_23; pfam13489 114615001669 Methyltransferase domain; Region: Methyltransf_11; pfam08241 114615001670 Domain of unknown function (DUF4167); Region: DUF4167; pfam13763 114615001671 N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase; Provisional; Region: PRK09328 114615001672 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 114615001673 S-adenosylmethionine binding site [chemical binding]; other site 114615001674 peptide chain release factor 2; Provisional; Region: PRK06746 114615001675 This domain is found in peptide chain release factors; Region: PCRF; smart00937 114615001676 RF-1 domain; Region: RF-1; pfam00472 114615001677 Signal transduction protein containing GAF and PtsI domains [Signal transduction mechanisms]; Region: PtsP; COG3605 114615001678 GAF domain; Region: GAF; pfam01590 114615001679 PEP-utilising enzyme, N-terminal; Region: PEP-utilisers_N; pfam05524 114615001680 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 114615001681 PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896 114615001682 aspartate kinase; Reviewed; Region: PRK06635 114615001683 AAK_AKii-LysC-BS: Amino Acid Kinase Superfamily (AAK), AKii; this CD includes the N-terminal catalytic aspartokinase (AK) domain of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis 168, and the lysine plus threonine-sensitive...; Region: AAK_AKii-LysC-BS; cd04261 114615001684 putative nucleotide binding site [chemical binding]; other site 114615001685 putative catalytic residues [active] 114615001686 putative Mg ion binding site [ion binding]; other site 114615001687 putative aspartate binding site [chemical binding]; other site 114615001688 ACT domains of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related proteins; Region: ACT_AKii-LysC-BS-like_1; cd04913 114615001689 putative allosteric regulatory site; other site 114615001690 ACT domains of the lysine-sensitive, aspartokinase (AK) isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related domains; Region: ACT_AKii-LysC-BS-like_2; cd04936 114615001691 putative allosteric regulatory residue; other site 114615001692 Bacterial PH domain; Region: DUF304; pfam03703 114615001693 bifunctional 3-demethylubiquinone-9 3-methyltransferase/ 2-octaprenyl-6-hydroxy phenol methylase; Provisional; Region: PRK05134 114615001694 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 114615001695 S-adenosylmethionine binding site [chemical binding]; other site 114615001696 GIY-YIG domain of uncharacterized hypothetical protein found in bacteria; Region: GIY-YIG_unchar_3; cd10448 114615001697 GIY-YIG motif/motif A; other site 114615001698 putative active site [active] 114615001699 putative metal binding site [ion binding]; other site 114615001700 Predicted membrane protein [Function unknown]; Region: COG2510 114615001701 Protein of unknown function (DUF1178); Region: DUF1178; pfam06676 114615001702 Nit1, Nit 2, and related proteins, and the Nit1-like domain of NitFhit (class 10 nitrilases); Region: nit; cd07572 114615001703 nitrilase; Region: PLN02798 114615001704 putative active site [active] 114615001705 catalytic triad [active] 114615001706 dimer interface [polypeptide binding]; other site 114615001707 Glutaredoxin (GRX) family, GRX bacterial class 1 and 3 (b_1_3)-like subfamily; composed of bacterial GRXs, approximately 10 kDa in size, and proteins containing a GRX or GRX-like domain. GRX is a glutathione (GSH) dependent reductase, catalyzing the...; Region: GRX_GRXb_1_3_like; cd03418 114615001708 GSH binding site [chemical binding]; other site 114615001709 catalytic residues [active] 114615001710 Predicted amidophosphoribosyltransferases [General function prediction only]; Region: ComFC; COG1040 114615001711 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 114615001712 active site 114615001713 Methyltransferase domain; Region: Methyltransf_23; pfam13489 114615001714 Methyltransferase domain; Region: Methyltransf_11; pfam08241 114615001715 The MutT pyrophosphohydrolase is a prototypical Nudix hydrolase that catalyzes the hydrolysis of nucleoside and deoxynucleoside triphosphates (NTPs and dNTPs) by substitution at a beta-phosphorus to yield a nucleotide monophosphate (NMP) and inorganic...; Region: MutT_pyrophosphohydrolase; cd03425 114615001716 active site 114615001717 8-oxo-dGMP binding site [chemical binding]; other site 114615001718 nudix motif; other site 114615001719 metal binding site [ion binding]; metal-binding site 114615001720 Putative Flp pilus-assembly TadE/G-like; Region: Tad; pfam13400 114615001721 Putative Tad-like Flp pilus-assembly; Region: Tad_C; pfam09977 114615001722 Ornithine acetyltransferase (OAT) family; also referred to as ArgJ. OAT catalyzes the first and fifth steps in arginine biosynthesis, coupling acetylation of glutamate with deacetylation of N-acetylornithine, which allows recycling of the acetyl group in...; Region: OAT; cd02152 114615001723 heterotetramer interface [polypeptide binding]; other site 114615001724 active site pocket [active] 114615001725 cleavage site 114615001726 PPIC-type PPIASE domain; Region: Rotamase; pfam00639 114615001727 preprotein translocase subunit SecA; Reviewed; Region: PRK12904 114615001728 SecA preprotein cross-linking domain; Region: SecA_PP_bind; smart00958 114615001729 SEC-C motif; Region: SEC-C; pfam02810 114615001730 Beta-glucosidase-related glycosidases [Carbohydrate transport and metabolism]; Region: BglX; COG1472 114615001731 Resolvase, N terminal domain; Region: Resolvase; smart00857 114615001732 Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; cl07971 114615001733 hypothetical protein; Provisional; Region: PRK07538 114615001734 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 114615001735 AMP-binding domain protein; Validated; Region: PRK07529 114615001736 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 114615001737 Uncharacterized subfamily of fatty acid CoA ligase (FACL); Region: FACL_like_4; cd05944 114615001738 acyl-activating enzyme (AAE) consensus motif; other site 114615001739 acyl-activating enzyme (AAE) consensus motif; other site 114615001740 putative AMP binding site [chemical binding]; other site 114615001741 putative active site [active] 114615001742 putative CoA binding site [chemical binding]; other site 114615001743 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3666 114615001744 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 114615001745 Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751 114615001746 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 114615001747 MarR family; Region: MarR_2; pfam12802 114615001748 Periplasmic binding protein; Region: Peripla_BP_6; pfam13458 114615001749 Type I periplasmic-binding protein of the nitrile hydratase (NHase) system that selectively converts nitriles to corresponding amides; Region: PBP1_NHase; cd06358 114615001750 putative ligand binding site [chemical binding]; other site 114615001751 MHYT domain (predicted integral membrane sensor domain) [Signal transduction mechanisms]; Region: COG3300 114615001752 Bacterial signalling protein N terminal repeat; Region: MHYT; pfam03707 114615001753 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 114615001754 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 114615001755 metal binding site [ion binding]; metal-binding site 114615001756 active site 114615001757 I-site; other site 114615001758 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 114615001759 membrane-bound PQQ-dependent dehydrogenase, glucose/quinate/shikimate family; Region: PQQ_membr_DH; TIGR03074 114615001760 Membrane-bound PQQ-dependent glucose dehydrogenase; Region: PQQ_mGDH; cd10280 114615001761 Trp docking motif [polypeptide binding]; other site 114615001762 putative active site [active] 114615001763 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3034 114615001764 acetyl-CoA carboxylase carboxyltransferase subunit alpha; Validated; Region: PRK05724 114615001765 acetyl-CoA carboxylase carboxyltransferase alpha subunit; Provisional; Region: accA; CHL00198 114615001766 tyrosine recombinase XerD; Region: recomb_XerD; TIGR02225 114615001767 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 114615001768 active site 114615001769 DNA binding site [nucleotide binding] 114615001770 Int/Topo IB signature motif; other site 114615001771 shikimate kinase; Provisional; Region: PRK13946 114615001772 Shikimate kinase (SK) is the fifth enzyme in the shikimate pathway, a seven-step biosynthetic pathway which converts erythrose-4-phosphate to chorismic acid, found in bacteria, fungi and plants. Chorismic acid is a important intermediate in the synthesis...; Region: SK; cd00464 114615001773 ADP binding site [chemical binding]; other site 114615001774 magnesium binding site [ion binding]; other site 114615001775 putative shikimate binding site; other site 114615001776 Dehydroquinate synthase (DHQS) catalyzes the conversion of DAHP to DHQ in shikimate pathway for aromatic compounds synthesis; Region: DHQS; cd08195 114615001777 Iron-containing alcohol dehydrogenase; Region: Fe-ADH; pfam00465 114615001778 active site 114615001779 dimer interface [polypeptide binding]; other site 114615001780 metal binding site [ion binding]; metal-binding site 114615001781 Putative Mg2+ and Co2+ transporter CorB [Inorganic ion transport and metabolism]; Region: CorB; COG4536 114615001782 Domain of unknown function DUF21; Region: DUF21; pfam01595 114615001783 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 114615001784 Transporter associated domain; Region: CorC_HlyC; smart01091 114615001785 Stress-induced morphogen (activity unknown) [Signal transduction mechanisms]; Region: BolA; COG0271 114615001786 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 114615001787 HSP70 interaction site [polypeptide binding]; other site 114615001788 Bacillus subtilis (Bs) citrate synthase CS-I_like. CS catalyzes the condensation of acetyl coenzyme A (AcCoA) and oxalacetate (OAA) to form citrate and coenzyme A (CoA), the first step in the citric acid cycle (TCA or Krebs cycle). 2MCS catalyzes the...; Region: BsCS-I_like; cd06109 114615001789 dimer interface [polypeptide binding]; other site 114615001790 Citrate synthase; Region: Citrate_synt; pfam00285 114615001791 active site 114615001792 citrylCoA binding site [chemical binding]; other site 114615001793 oxalacetate/citrate binding site [chemical binding]; other site 114615001794 coenzyme A binding site [chemical binding]; other site 114615001795 catalytic triad [active] 114615001796 Citrate synthase (CS) catalyzes the condensation of acetyl coenzyme A (AcCoA) and oxalacetate (OAA) to form citrate and coenzyme A (CoA), the first step in the oxidative citric acid cycle (TCA or Krebs cycle). Peroxisomal CS is involved in the glyoxylate...; Region: citrate_synt_like_2; cd06102 114615001797 dimer interface [polypeptide binding]; other site 114615001798 Citrate synthase; Region: Citrate_synt; pfam00285 114615001799 active site 114615001800 oxalacetate/citrate binding site [chemical binding]; other site 114615001801 citrylCoA binding site [chemical binding]; other site 114615001802 coenzyme A binding site [chemical binding]; other site 114615001803 catalytic triad [active] 114615001804 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 114615001805 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 114615001806 cobaltochelatase, CobS subunit; Region: PD_CobS; TIGR01650 114615001807 Cobaltochelatase CobS subunit N terminal; Region: CobS_N; pfam12556 114615001808 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189 114615001809 Cobalamin biosynthesis protein CobT; Region: CobT; pfam06213 114615001810 cobaltochelatase, CobT subunit; Region: CobT; TIGR01651 114615001811 norD type: Denitrifying bacteria contain both membrane bound and periplasmic nitrate reductases. Denitrification plays a major role in completing the nitrogen cycle by converting nitrate or nitrite to nitrogen gas. The pathway for microbial...; Region: vWA_norD_type; cd01454 114615001812 metal ion-dependent adhesion site (MIDAS); other site 114615001813 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4246 114615001814 Esterase-like activity of phytase; Region: Phytase-like; pfam13449 114615001815 NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902 114615001816 Old yellow enzyme (OYE) YqjM-like FMN binding domain. YqjM is involved in the oxidative stress response of Bacillus subtilis. Like the other OYE members, each monomer of YqjM contains FMN as a non-covalently bound cofactor and uses NADPH as a reducing...; Region: OYE_YqiM_FMN; cd02932 114615001817 active site 114615001818 FMN binding site [chemical binding]; other site 114615001819 substrate binding site [chemical binding]; other site 114615001820 homotetramer interface [polypeptide binding]; other site 114615001821 catalytic residue [active] 114615001822 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 114615001823 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases [Energy production and conversion]; Region: COG2141 114615001824 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_13; cd08517 114615001825 Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496 114615001826 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 114615001827 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 114615001828 dimer interface [polypeptide binding]; other site 114615001829 conserved gate region; other site 114615001830 putative PBP binding loops; other site 114615001831 ABC-ATPase subunit interface; other site 114615001832 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 114615001833 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 114615001834 dimer interface [polypeptide binding]; other site 114615001835 conserved gate region; other site 114615001836 putative PBP binding loops; other site 114615001837 ABC-ATPase subunit interface; other site 114615001838 ATPase components of various ABC-type transport systems, contain duplicated ATPase [General function prediction only]; Region: COG1123 114615001839 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 114615001840 Walker A/P-loop; other site 114615001841 ATP binding site [chemical binding]; other site 114615001842 Q-loop/lid; other site 114615001843 ABC transporter signature motif; other site 114615001844 Walker B; other site 114615001845 D-loop; other site 114615001846 H-loop/switch region; other site 114615001847 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; pfam08352 114615001848 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 114615001849 Walker A/P-loop; other site 114615001850 ATP binding site [chemical binding]; other site 114615001851 Q-loop/lid; other site 114615001852 ABC transporter signature motif; other site 114615001853 Walker B; other site 114615001854 D-loop; other site 114615001855 H-loop/switch region; other site 114615001856 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 114615001857 30S ribosomal protein S21; Reviewed; Region: rpsU; PRK00270 114615001858 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 114615001859 DNA-binding site [nucleotide binding]; DNA binding site 114615001860 RNA-binding motif; other site 114615001861 Uncharacterized conserved protein (DUF2235); Region: DUF2235; pfam09994 114615001862 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 114615001863 50S ribosomal protein L28; Reviewed; Region: rpmB; PRK00359 114615001864 Protein of unknown function (DUF3108); Region: DUF3108; pfam11306 114615001865 Superfamily II DNA and RNA helicases [DNA replication, recombination, and repair / Transcription / Translation, ribosomal structure and biogenesis]; Region: SrmB; COG0513 114615001866 DEAD/DEAH box helicase; Region: DEAD; pfam00270 114615001867 ATP binding site [chemical binding]; other site 114615001868 putative Mg++ binding site [ion binding]; other site 114615001869 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 114615001870 nucleotide binding region [chemical binding]; other site 114615001871 ATP-binding site [chemical binding]; other site 114615001872 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 114615001873 RNA binding surface [nucleotide binding]; other site 114615001874 Domain of unknown function (DUF3470); Region: DUF3470; pfam11953 114615001875 Transcriptional regulators, similar to M. xanthus CarD [Transcription]; Region: COG1329 114615001876 Putative Zn-dependent protease [General function prediction only]; Region: COG4784 114615001877 Peptidase family M48; Region: Peptidase_M48; pfam01435 114615001878 Micrococcal nuclease (thermonuclease) homologs [DNA replication, recombination, and repair]; Region: COG1525 114615001879 Periplasmic binding protein; Region: Peripla_BP_6; pfam13458 114615001880 Periplasmic solute-binding domain of active transport proteins that belong to the type I periplasmic binding fold protein family; Region: PBP1_SBP_like_1; cd06327 114615001881 putative ligand binding site [chemical binding]; other site 114615001882 enoyl-CoA hydratase; Provisional; Region: PRK06688 114615001883 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 114615001884 substrate binding site [chemical binding]; other site 114615001885 oxyanion hole (OAH) forming residues; other site 114615001886 trimer interface [polypeptide binding]; other site 114615001887 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 114615001888 active site 114615001889 metal binding site [ion binding]; metal-binding site 114615001890 PGDYG protein; Region: PGDYG; pfam14083 114615001891 TIR domain; Region: TIR_2; pfam13676 114615001892 CHAT domain; Region: CHAT; cl17868 114615001893 Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024 114615001894 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 114615001895 substrate binding site [chemical binding]; other site 114615001896 oxyanion hole (OAH) forming residues; other site 114615001897 trimer interface [polypeptide binding]; other site 114615001898 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 114615001899 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 114615001900 active site 114615001901 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 114615001902 Acyl-CoA dehydrogenase, N-terminal domain; Region: Acyl-CoA_dh_N; pfam02771 114615001903 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 114615001904 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK07231 114615001905 classical (c) SDRs; Region: SDR_c; cd05233 114615001906 NAD(P) binding site [chemical binding]; other site 114615001907 active site 114615001908 Predicted membrane protein [Function unknown]; Region: COG2261 114615001909 Bacterial protein of unknown function (DUF937); Region: DUF937; cl01528 114615001910 carotene isomerase; Region: carot_isom; TIGR02730 114615001911 M28 Zn-Peptidases; Region: M28_like_6; cd08656 114615001912 Peptidase family M28; Region: Peptidase_M28; pfam04389 114615001913 metal binding site [ion binding]; metal-binding site 114615001914 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 114615001915 S-adenosylmethionine binding site [chemical binding]; other site 114615001916 Conserved protein/domain typically associated with flavoprotein oxygenases, DIM6/NTAB family [General function prediction only]; Region: COG1853 114615001917 PAP2_like proteins, a super-family of histidine phosphatases and vanadium haloperoxidases, includes type 2 phosphatidic acid phosphatase or lipid phosphate phosphatase (LPP), Glucose-6-phosphatase, Phosphatidylglycerophosphatase B and bacterial acid...; Region: PAP2_like; cl00474 114615001918 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 114615001919 active site 114615001920 Uncharacterized protein with a C-terminal OMP (outer membrane protein) domain [Function unknown]; Region: COG4625 114615001921 Autotransporter beta-domain; Region: Autotransporter; smart00869 114615001922 TPR repeat; Region: TPR_11; pfam13414 114615001923 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 114615001924 binding surface 114615001925 TPR motif; other site 114615001926 TPR repeat; Region: TPR_11; pfam13414 114615001927 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 114615001928 binding surface 114615001929 TPR motif; other site 114615001930 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 114615001931 probable oxidoreductase, LLM family; Region: LLM_2I7G; TIGR03858 114615001932 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases [Energy production and conversion]; Region: COG2141 114615001933 hypothetical protein; Validated; Region: PRK07581 114615001934 Homoserine acetyltransferase [Amino acid transport and metabolism]; Region: MET2; COG2021 114615001935 This CD includes the putative hydrocarbon oxygenase, MocD, a bacterial rhizopine (3-O-methyl-scyllo-inosamine, 3-O-MSI) oxygenase, and other related proteins. It has been proposed that MocD, MocE (Rieske-like ferredoxin), and MocF (ferredoxin reductase)...; Region: Rhizopine-oxygenase-like; cd03511 114615001936 Fatty acid desaturase; Region: FA_desaturase; pfam00487 114615001937 putative di-iron ligands [ion binding]; other site 114615001938 Superfamily I DNA and RNA helicases [DNA replication, recombination, and repair]; Region: UvrD; COG0210 114615001939 Part of AAA domain; Region: AAA_19; pfam13245 114615001940 Family description; Region: UvrD_C_2; pfam13538 114615001941 Transcriptional accessory protein [Transcription]; Region: Tex; COG2183 114615001942 Tex-like protein N-terminal domain; Region: Tex_N; pfam09371 114615001943 Likely ribonuclease with RNase H fold; Region: YqgFc; smart00732 114615001944 S1_Tex: The C-terminal S1 domain of a transcription accessory factor called Tex, which has been characterized in Bordetella pertussis and Pseudomonas aeruginosa. The tex gene is essential in Bortella pertusis and is named for its role in toxin expression; Region: S1_Tex; cd05685 114615001945 RNA binding site [nucleotide binding]; other site 114615001946 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 114615001947 NAD(P) binding site [chemical binding]; other site 114615001948 active site 114615001949 tryptophan tryptophylquinone biosynthesis enzyme MauG; Region: TTQ_mauG; TIGR03791 114615001950 Cupredoxin-like domain; Region: Cupredoxin_1; cl17234 114615001951 Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840 114615001952 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 114615001953 dimerization interface [polypeptide binding]; other site 114615001954 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 114615001955 dimer interface [polypeptide binding]; other site 114615001956 putative CheW interface [polypeptide binding]; other site 114615001957 TRAP-type C4-dicarboxylate transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: DctP; COG1638 114615001958 Bacterial extracellular solute-binding protein, family 7; Region: SBP_bac_7; cl15441 114615001959 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 114615001960 dimerization interface [polypeptide binding]; other site 114615001961 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 114615001962 dimer interface [polypeptide binding]; other site 114615001963 putative CheW interface [polypeptide binding]; other site 114615001964 Predicted hydrolase of the alpha/beta-hydrolase fold [General function prediction only]; Region: COG3571 114615001965 ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components [Inorganic ion transport and metabolism]; Region: TauA; COG0715 114615001966 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cl17432 114615001967 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 114615001968 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 114615001969 Walker A/P-loop; other site 114615001970 ATP binding site [chemical binding]; other site 114615001971 Q-loop/lid; other site 114615001972 ABC transporter signature motif; other site 114615001973 Walker B; other site 114615001974 D-loop; other site 114615001975 H-loop/switch region; other site 114615001976 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 114615001977 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 114615001978 dimer interface [polypeptide binding]; other site 114615001979 conserved gate region; other site 114615001980 putative PBP binding loops; other site 114615001981 ABC-ATPase subunit interface; other site 114615001982 gentisate 1,2-dioxygenase; Region: gentisate_1_2; TIGR02272 114615001983 Cupin domain; Region: Cupin_2; pfam07883 114615001984 Cupin domain; Region: Cupin_2; cl17218 114615001985 GST_N family, Class Zeta subfamily; GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of endogenous and xenobiotic alkylating agents, including carcinogens; Region: GST_N_Zeta; cd03042 114615001986 maleylacetoacetate isomerase; Region: maiA; TIGR01262 114615001987 C-terminal domain interface [polypeptide binding]; other site 114615001988 GSH binding site (G-site) [chemical binding]; other site 114615001989 putative dimer interface [polypeptide binding]; other site 114615001990 C-terminal, alpha helical domain of Class Zeta Glutathione S-transferases; Region: GST_C_Zeta; cd03191 114615001991 dimer interface [polypeptide binding]; other site 114615001992 N-terminal domain interface [polypeptide binding]; other site 114615001993 maleylacetoacetate (MAA) substrate binding site (H site) [chemical binding]; other site 114615001994 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 114615001995 MarR family; Region: MarR_2; pfam12802 114615001996 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 114615001997 benzoate-CoA ligase family; Region: benz_CoA_lig; TIGR02262 114615001998 acyl-activating enzyme (AAE) consensus motif; other site 114615001999 AMP binding site [chemical binding]; other site 114615002000 active site 114615002001 CoA binding site [chemical binding]; other site 114615002002 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases [Coenzyme metabolism / Energy production and conversion]; Region: UbiH; COG0654 114615002003 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 114615002004 Sodium:dicarboxylate symporter family; Region: SDF; pfam00375 114615002005 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 114615002006 glutamate and aspartate transporter subunit; Provisional; Region: PRK10797 114615002007 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 114615002008 substrate binding pocket [chemical binding]; other site 114615002009 membrane-bound complex binding site; other site 114615002010 hinge residues; other site 114615002011 cyanophycin synthetase; Region: cya_phycin_syn; TIGR02068 114615002012 Flavodoxin reductases (ferredoxin-NADPH reductases) family 1 [Energy production and conversion]; Region: Hmp; COG1018 114615002013 Ferredoxin-NADP+ (oxido)reductase is an FAD-containing enzyme that catalyzes the reversible electron transfer between NADP(H) and electron carrier proteins such as ferredoxin and flavodoxin. Isoforms of these flavoproteins (i.e. having a non-covalently...; Region: FNR1; cd06195 114615002014 FAD binding pocket [chemical binding]; other site 114615002015 FAD binding motif [chemical binding]; other site 114615002016 phosphate binding motif [ion binding]; other site 114615002017 beta-alpha-beta structure motif; other site 114615002018 NAD binding pocket [chemical binding]; other site 114615002019 acyl-CoA synthetase; Validated; Region: PRK08316 114615002020 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 114615002021 Bacterial Bile acid CoA ligases and similar proteins; Region: BACL_like; cd05929 114615002022 acyl-activating enzyme (AAE) consensus motif; other site 114615002023 putative AMP binding site [chemical binding]; other site 114615002024 putative active site [active] 114615002025 putative CoA binding site [chemical binding]; other site 114615002026 Glutamate synthase domain 2 [Amino acid transport and metabolism]; Region: GltB; COG0069 114615002027 Glutamate synthase (GltS) FMN-binding domain. GltS is a complex iron-sulfur flavoprotein that catalyzes the reductive synthesis of L-glutamate from 2-oxoglutarate and L-glutamine via intramolecular channelling of ammonia, a reaction in the plant, yeast...; Region: GltS_FMN; cd02808 114615002028 active site 114615002029 FMN binding site [chemical binding]; other site 114615002030 substrate binding site [chemical binding]; other site 114615002031 3Fe-4S cluster binding site [ion binding]; other site 114615002032 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 114615002033 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 114615002034 Walker A/P-loop; other site 114615002035 ATP binding site [chemical binding]; other site 114615002036 Q-loop/lid; other site 114615002037 ABC transporter signature motif; other site 114615002038 Walker B; other site 114615002039 D-loop; other site 114615002040 H-loop/switch region; other site 114615002041 ABC nitrate/sulfonate/bicarbonate family transporter, ATPase subunit; Region: ABC_transp; pfam09821 114615002042 ABC-type anion transport system, duplicated permease component [Inorganic ion transport and metabolism]; Region: COG4986 114615002043 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 114615002044 dimer interface [polypeptide binding]; other site 114615002045 conserved gate region; other site 114615002046 putative PBP binding loops; other site 114615002047 ABC-ATPase subunit interface; other site 114615002048 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 114615002049 dimer interface [polypeptide binding]; other site 114615002050 ABC-ATPase subunit interface; other site 114615002051 putative PBP binding loops; other site 114615002052 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 114615002053 Domain of unknown function DUF21; Region: DUF21; pfam01595 114615002054 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 114615002055 Transporter associated domain; Region: CorC_HlyC; smart01091 114615002056 Opacity protein and related surface antigens [Cell envelope biogenesis, outer membrane]; Region: COG3637 114615002057 Carbohydrate-selective porin, OprB family; Region: OprB; pfam04966 114615002058 Creatinine amidohydrolase; Region: Creatininase; pfam02633 114615002059 ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components [Inorganic ion transport and metabolism]; Region: TauA; COG0715 114615002060 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cl17432 114615002061 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 114615002062 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 114615002063 Walker A/P-loop; other site 114615002064 ATP binding site [chemical binding]; other site 114615002065 Q-loop/lid; other site 114615002066 ABC transporter signature motif; other site 114615002067 Walker B; other site 114615002068 D-loop; other site 114615002069 H-loop/switch region; other site 114615002070 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 114615002071 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 114615002072 Lactate dehydrogenase and related dehydrogenases [Energy production and conversion / Coenzyme metabolism / General function prediction only]; Region: LdhA; COG1052 114615002073 Hydroxy(phenyl)pyruvate Reductase, D-isomer-specific 2-hydroxyacid-related dehydrogenase; Region: HPPR; cd12156 114615002074 putative ligand binding site [chemical binding]; other site 114615002075 NAD binding site [chemical binding]; other site 114615002076 catalytic site [active] 114615002077 PAS fold; Region: PAS_7; pfam12860 114615002078 PAS fold; Region: PAS_4; pfam08448 114615002079 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 114615002080 putative active site [active] 114615002081 heme pocket [chemical binding]; other site 114615002082 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 114615002083 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 114615002084 DNA-binding site [nucleotide binding]; DNA binding site 114615002085 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 114615002086 pyridoxal 5'-phosphate binding site [chemical binding]; other site 114615002087 homodimer interface [polypeptide binding]; other site 114615002088 catalytic residue [active] 114615002089 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 114615002090 EamA-like transporter family; Region: EamA; pfam00892 114615002091 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 114615002092 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 114615002093 ligand binding site [chemical binding]; other site 114615002094 flexible hinge region; other site 114615002095 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 114615002096 putative switch regulator; other site 114615002097 non-specific DNA interactions [nucleotide binding]; other site 114615002098 DNA binding site [nucleotide binding] 114615002099 sequence specific DNA binding site [nucleotide binding]; other site 114615002100 putative cAMP binding site [chemical binding]; other site 114615002101 hypothetical protein; Reviewed; Region: PRK00024 114615002102 Dehydroquinate synthase-like (DHQ-like) and iron-containing alcohol dehydrogenases (Fe-ADH); Region: DHQ_Fe-ADH; cl02872 114615002103 Mov34/MPN/PAD-1 family; Region: MPN_DUF2466; cd08071 114615002104 MPN+ (JAMM) motif; other site 114615002105 Zinc-binding site [ion binding]; other site 114615002106 Bacterial transcriptional activator domain; Region: BTAD; smart01043 114615002107 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 114615002108 Putative protein-S-isoprenylcysteine methyltransferase [Posttranslational modification, protein turnover, chaperones]; Region: STE14; COG2020 114615002109 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 114615002110 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 114615002111 putative substrate translocation pore; other site 114615002112 Intradiol dioxygenase supgroup. Intradiol dioxygenases catalyze the critical ring-cleavage step in the conversion of catecholate derivatives to citric acid cycle intermediates. They break the catechol C1-C2 bond and utilize Fe3+, as opposed to the...; Region: intradiol_dioxygenase_like; cd03457 114615002113 putative active site [active] 114615002114 Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086 114615002115 active site 114615002116 Mechanosensitive ion channel; Region: MS_channel; pfam00924 114615002117 potassium/proton antiporter; Reviewed; Region: PRK05326 114615002118 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; cl10482 114615002119 TrkA-C domain; Region: TrkA_C; pfam02080 114615002120 Transporter associated domain; Region: CorC_HlyC; smart01091 114615002121 Plasmid stabilization system protein [General function prediction only]; Region: ParE; COG3668 114615002122 penicillin-insensitive murein endopeptidase; Reviewed; Region: mepA; PRK09429 114615002123 PAS fold; Region: PAS_7; pfam12860 114615002124 PAS domain S-box; Region: sensory_box; TIGR00229 114615002125 PAS domain; Region: PAS; smart00091 114615002126 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 114615002127 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 114615002128 metal binding site [ion binding]; metal-binding site 114615002129 active site 114615002130 I-site; other site 114615002131 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 114615002132 transcriptional activator FtrA; Provisional; Region: ftrA; PRK09393 114615002133 AraC transcriptional regulators having a Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GATase1_AraC_1; cd03137 114615002134 conserved cys residue [active] 114615002135 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 114615002136 Member of the Rhodanese Homology Domain superfamily. This CD includes the putative rhodanese-like protein, Psp2, of Yersinia pestis biovar Medievalis and other similar uncharacterized proteins; Region: RHOD_PspE2; cd01521 114615002137 active site residue [active] 114615002138 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 114615002139 dimerization interface [polypeptide binding]; other site 114615002140 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 114615002141 dimer interface [polypeptide binding]; other site 114615002142 putative CheW interface [polypeptide binding]; other site 114615002143 GTP-binding protein LepA; Provisional; Region: PRK05433 114615002144 LepA also known as Elongation Factor 4 (EF4); Region: LepA; cd01890 114615002145 G1 box; other site 114615002146 putative GEF interaction site [polypeptide binding]; other site 114615002147 GTP/Mg2+ binding site [chemical binding]; other site 114615002148 Switch I region; other site 114615002149 G2 box; other site 114615002150 G3 box; other site 114615002151 Switch II region; other site 114615002152 G4 box; other site 114615002153 G5 box; other site 114615002154 Translation_Factor_II_like: Elongation factor Tu (EF-Tu) domain II-like proteins. Elongation factor Tu consists of three structural domains, this family represents the second domain. Domain II adopts a beta barrel structure and is involved in binding to...; Region: Translation_Factor_II_like; cl02787 114615002155 lepA_C: This family represents the C-terminal region of LepA, a GTP-binding protein localized in the cytoplasmic membrane. LepA is ubiquitous in Bacteria and Eukaryota (e.g. Saccharomyces cerevisiae GUF1p), but is missing from Archaea. LepA exhibits...; Region: lepA_C; cd03709 114615002156 GTP-binding protein LepA C-terminus; Region: LepA_C; pfam06421 114615002157 4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family [Cell envelope biogenesis, outer membrane]; Region: ArnT; COG1807 114615002158 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; pfam13231 114615002159 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367 114615002160 dimerization domain swap beta strand [polypeptide binding]; other site 114615002161 regulatory protein interface [polypeptide binding]; other site 114615002162 active site 114615002163 regulatory phosphorylation site [posttranslational modification]; other site 114615002164 PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cl00025 114615002165 active site 114615002166 HprK/P, the bifunctional histidine-containing protein kinase/phosphatase, controls the phosphorylation state of the phosphocarrier protein HPr and regulates the utilization of carbon sources by gram-positive bacteria. It catalyzes both the ATP-dependent...; Region: HprK_C; cd01918 114615002167 Hpr binding site; other site 114615002168 active site 114615002169 homohexamer subunit interaction site [polypeptide binding]; other site 114615002170 Sensor N-terminal transmembrane domain; Region: Sensor_TM1; pfam13755 114615002171 Stimulus-sensing domain; Region: Stimulus_sens_1; pfam13756 114615002172 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 114615002173 HAMP domain; Region: HAMP; pfam00672 114615002174 dimerization interface [polypeptide binding]; other site 114615002175 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 114615002176 dimer interface [polypeptide binding]; other site 114615002177 phosphorylation site [posttranslational modification] 114615002178 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 114615002179 ATP binding site [chemical binding]; other site 114615002180 Mg2+ binding site [ion binding]; other site 114615002181 G-X-G motif; other site 114615002182 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 114615002183 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 114615002184 active site 114615002185 phosphorylation site [posttranslational modification] 114615002186 intermolecular recognition site; other site 114615002187 dimerization interface [polypeptide binding]; other site 114615002188 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 114615002189 DNA binding site [nucleotide binding] 114615002190 Pyridoxamine 5'-phosphate oxidase; Region: Pyrid_oxidase_2; pfam13883 114615002191 Putative heme iron utilization protein [Inorganic ion transport and metabolism]; Region: HugZ; COG0748 114615002192 Protein of unknown function (DUF2470); Region: DUF2470; pfam10615 114615002193 Phosphoenolpyruvate carboxykinase; Region: PEPCK_ATP; pfam01293 114615002194 Phosphoenolpyruvate carboxykinase (PEPCK), a critical gluconeogenic enzyme, catalyzes the first committed step in the diversion of tricarboxylic acid cycle intermediates toward gluconeogenesis. It catalyzes the reversible decarboxylation and...; Region: PEPCK_ATP; cd00484 114615002195 active site 114615002196 substrate-binding site [chemical binding]; other site 114615002197 metal-binding site [ion binding] 114615002198 ATP binding site [chemical binding]; other site 114615002199 Thioesterase-like superfamily; Region: 4HBT_3; pfam13622 114615002200 This is a family of oligosaccharide phosphorylases. It includes yeast and mammalian glycogen phosphorylases, plant starch/glucan phosphorylase, as well as the maltodextrin phosphorylases of bacteria. The members of this family catalyze the breakdown of...; Region: GT1_Glycogen_Phosphorylase; cd04300 114615002201 homodimer interface [polypeptide binding]; other site 114615002202 glycogen/starch/alpha-glucan phosphorylases; Region: P_ylase; TIGR02093 114615002203 active site pocket [active] 114615002204 Protein of unknown function (DUF2865); Region: DUF2865; pfam11064 114615002205 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 114615002206 active site 114615002207 GSH-dependent disulfide bond oxidoreductase; Provisional; Region: PRK13972 114615002208 GST_N family, Ure2p-like subfamily; composed of the Saccharomyces cerevisiae Ure2p and related GSTs. Ure2p is a regulator for nitrogen catabolism in yeast. It represses the expression of several gene products involved in the use of poor nitrogen sources...; Region: GST_N_Ure2p_like; cd03048 114615002209 C-terminal domain interface [polypeptide binding]; other site 114615002210 GSH binding site (G-site) [chemical binding]; other site 114615002211 dimer interface [polypeptide binding]; other site 114615002212 C-terminal, alpha helical domain of Escherichia coli YfcG Glutathione S-transferases and related uncharacterized proteins; Region: GST_C_YfcG_like; cd10291 114615002213 N-terminal domain interface [polypeptide binding]; other site 114615002214 putative dimer interface [polypeptide binding]; other site 114615002215 active site 114615002216 Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885 114615002217 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 114615002218 ligand binding site [chemical binding]; other site 114615002219 Protein of unknown function (DUF2029); Region: DUF2029; pfam09594 114615002220 5'-3' exonuclease; Region: 53EXOc; smart00475 114615002221 PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859 114615002222 active site 114615002223 metal binding site 1 [ion binding]; metal-binding site 114615002224 putative 5' ssDNA interaction site; other site 114615002225 metal binding site 3; metal-binding site 114615002226 metal binding site 2 [ion binding]; metal-binding site 114615002227 H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898 114615002228 putative DNA binding site [nucleotide binding]; other site 114615002229 putative metal binding site [ion binding]; other site 114615002230 DNA polymerase I - 3'-5' exonuclease and polymerase domains [DNA replication, recombination, and repair]; Region: PolA; COG0749 114615002231 DEDDy 3'-5' exonuclease domain of Escherichia coli DNA polymerase I and similar bacterial family-A DNA polymerases; Region: DNA_polA_I_Ecoli_like_exo; cd06139 114615002232 active site 114615002233 catalytic site [active] 114615002234 substrate binding site [chemical binding]; other site 114615002235 Polymerase I functions primarily to fill DNA gaps that arise during DNA repair, recombination and replication; Region: DNA_pol_A_pol_I_C; cd08637 114615002236 active site 114615002237 DNA binding site [nucleotide binding] 114615002238 catalytic site [active] 114615002239 Predicted membrane protein [Function unknown]; Region: COG4763 114615002240 Acyltransferase family; Region: Acyl_transf_3; pfam01757 114615002241 Predicted UDP-glucose 6-dehydrogenase [Cell envelope biogenesis, outer membrane]; Region: Ugd; COG1004 114615002242 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210 114615002243 UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984 114615002244 UDP binding domain; Region: UDPG_MGDP_dh_C; smart00984 114615002245 ATP-dependent helicase HrpB; Region: DEAH_box_HrpB; TIGR01970 114615002246 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 114615002247 ATP binding site [chemical binding]; other site 114615002248 putative Mg++ binding site [ion binding]; other site 114615002249 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 114615002250 nucleotide binding region [chemical binding]; other site 114615002251 ATP-binding site [chemical binding]; other site 114615002252 ATP-dependent helicase C-terminal; Region: HrpB_C; pfam08482 114615002253 Bacterial aspartate proteases, retropepsin-like protease family; Region: retropepsin_like_bacteria; cd05483 114615002254 catalytic motif [active] 114615002255 Catalytic residue [active] 114615002256 Phosphomannomutase [Carbohydrate transport and metabolism]; Region: {ManB}; COG1109 114615002257 The phosphomannomutase/phosphoglucomutase (PMM/PGM) bifunctional enzyme catalyzes the reversible conversion of 1-phospho to 6-phospho-sugars (e.g. between mannose-1-phosphate and mannose-6-phosphate or glucose-1-phosphate and glucose-6-phosphate) via a...; Region: PMM_PGM; cd03089 114615002258 active site 114615002259 substrate binding site [chemical binding]; other site 114615002260 metal binding site [ion binding]; metal-binding site 114615002261 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 114615002262 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 114615002263 dimer interface [polypeptide binding]; other site 114615002264 putative CheW interface [polypeptide binding]; other site 114615002265 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 114615002266 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 114615002267 putative DNA binding site [nucleotide binding]; other site 114615002268 putative Zn2+ binding site [ion binding]; other site 114615002269 AsnC family; Region: AsnC_trans_reg; pfam01037 114615002270 NTP pyrophosphohydrolases containing a Zn-finger, probably nucleic-acid-binding [DNA replication, recombination, and repair]; Region: NPY1; COG2816 114615002271 NADH pyrophosphatase-like rudimentary NUDIX domain; Region: NUDIX-like; pfam09296 114615002272 NADH pyrophosphatase zinc ribbon domain; Region: zf-NADH-PPase; pfam09297 114615002273 NADH pyrophosphatase, a member of the Nudix hydrolase superfamily, catalyzes the cleavage of NADH into reduced nicotinamide mononucleotide (NMNH) and AMP. Like other members of the Nudix family, it requires a divalent cation, such as Mg2+ or Mn2+, for...; Region: NADH_pyrophosphatase; cd03429 114615002274 putative NADH binding site [chemical binding]; other site 114615002275 putative active site [active] 114615002276 nudix motif; other site 114615002277 putative metal binding site [ion binding]; other site 114615002278 Diadenosine tetraphosphate (Ap4A) hydrolase and other HIT family hydrolases [Nucleotide transport and metabolism / Carbohydrate transport and metabolism / General function prediction only]; Region: Hit; COG0537 114615002279 nucleotide binding site/active site [active] 114615002280 HIT family signature motif; other site 114615002281 catalytic residue [active] 114615002282 DNA polymerase III subunits gamma and tau; Validated; Region: PRK09111 114615002283 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 114615002284 Walker A motif; other site 114615002285 ATP binding site [chemical binding]; other site 114615002286 Walker B motif; other site 114615002287 arginine finger; other site 114615002288 DNA polymerase III subunits gamma and tau domain III; Region: DNA_pol3_gamma3; pfam12169 114615002289 DNA polymerase III gamma and tau subunits C terminal; Region: DUF3646; pfam12362 114615002290 hypothetical protein; Validated; Region: PRK00153 114615002291 recombination protein RecR; Reviewed; Region: recR; PRK00076 114615002292 RecR protein; Region: RecR; pfam02132 114615002293 TOPRIM_recR: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in Escherichia coli RecR. RecR participates in the RecFOR pathway of homologous recombinational repair in prokaryotes. This pathway provides a...; Region: TOPRIM_recR; cd01025 114615002294 tetramer interface [polypeptide binding]; other site 114615002295 putative active site [active] 114615002296 putative metal-binding site [ion binding]; other site 114615002297 muropeptide transporter; Validated; Region: ampG; cl17669 114615002298 muropeptide transporter; Reviewed; Region: ampG; PRK11902 114615002299 GIY-YIG domain of uncharacterized hypothetical protein found in bacteria; Region: GIY-YIG_unchar_3; cd10448 114615002300 GIY-YIG motif/motif A; other site 114615002301 putative active site [active] 114615002302 putative metal binding site [ion binding]; other site 114615002303 RmuC family; Region: RmuC; pfam02646 114615002304 Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487 114615002305 active site 114615002306 catalytic residues [active] 114615002307 metal binding site [ion binding]; metal-binding site 114615002308 methionyl-tRNA formyltransferase; Reviewed; Region: fmt; PRK00005 114615002309 Methionyl-tRNA formyltransferase, N-terminal hydrolase domain; Region: FMT_core_Met-tRNA-FMT_N; cd08646 114615002310 putative active site [active] 114615002311 substrate binding site [chemical binding]; other site 114615002312 putative cosubstrate binding site; other site 114615002313 catalytic site [active] 114615002314 C-terminal domain of Formyltransferase and other enzymes; Region: Met_tRNA_FMT_C; cd08704 114615002315 substrate binding site [chemical binding]; other site 114615002316 tRNA pseudouridine synthase A; Validated; Region: truA; PRK00021 114615002317 Eukaryotic and bacterial pseudouridine synthases similar to E. coli TruA; Region: PseudoU_synth_EcTruA; cd02570 114615002318 dimerization interface 3.5A [polypeptide binding]; other site 114615002319 active site 114615002320 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 114615002321 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 114615002322 dimer interface [polypeptide binding]; other site 114615002323 putative CheW interface [polypeptide binding]; other site 114615002324 succinyl-diaminopimelate desuccinylase; Reviewed; Region: PRK13009 114615002325 M20 Peptidase proteobacterial DapE encoded N-succinyl-L,L-diaminopimelic acid desuccinylase; Region: M20_DapE_proteobac; cd03891 114615002326 metal binding site [ion binding]; metal-binding site 114615002327 dimer interface [polypeptide binding]; other site 114615002328 2,3,4,5-tetrahydropyridine-2,6-carboxylate N-succinyltransferase; Provisional; Region: dapD; PRK11830 114615002329 2,3,4,5-tetrahydropyridine-2,6-dicarboxylate (THDP) N-succinyltransferase (also called THP succinyltransferase): THDP N-succinyltransferase catalyzes the conversion of tetrahydrodipicolinate and succinyl-CoA to N-succinyltetrahydrodipicolinate and CoA; Region: LbH_THP_succinylT; cd03350 114615002330 trimer interface [polypeptide binding]; other site 114615002331 active site 114615002332 substrate binding site [chemical binding]; other site 114615002333 CoA binding site [chemical binding]; other site 114615002334 pyrimidine 5'-nucleotidase; Region: Pyr-5-nucltdase; TIGR01993 114615002335 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 114615002336 motif II; other site 114615002337 Protein of unknown function (DUF1036); Region: DUF1036; cl02296 114615002338 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 114615002339 Protein of unknown function (DUF1036); Region: DUF1036; pfam06282 114615002340 AAK_NAGK-C: N-Acetyl-L-glutamate kinase - cyclic (NAGK-C) catalyzes the phosphorylation of the gamma-COOH group of N-acetyl-L-glutamate (NAG) by ATP in the second step of arginine biosynthesis found in some bacteria and photosynthetic organisms using the...; Region: AAK_NAGK-C; cd04250 114615002341 feedback inhibition sensing region; other site 114615002342 homohexameric interface [polypeptide binding]; other site 114615002343 nucleotide binding site [chemical binding]; other site 114615002344 N-acetyl-L-glutamate binding site [chemical binding]; other site 114615002345 Protein of unknown function (DUF423); Region: DUF423; pfam04241 114615002346 YihA (EngB) GTPase family; Region: YihA_EngB; cd01876 114615002347 G1 box; other site 114615002348 GTP/Mg2+ binding site [chemical binding]; other site 114615002349 Switch I region; other site 114615002350 G2 box; other site 114615002351 G3 box; other site 114615002352 Switch II region; other site 114615002353 G4 box; other site 114615002354 G5 box; other site 114615002355 membrane protein insertase; Provisional; Region: PRK01318 114615002356 membrane protein insertase, YidC/Oxa1 family, C-terminal domain; Region: yidC_oxa1_cterm; TIGR03592 114615002357 Ribonuclease P; Region: Ribonuclease_P; cl00457 114615002358 Ribosomal protein L34; Region: Ribosomal_L34; cl00370 114615002359 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 114615002360 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 114615002361 ATP binding site [chemical binding]; other site 114615002362 Mg2+ binding site [ion binding]; other site 114615002363 G-X-G motif; other site 114615002364 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 114615002365 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 114615002366 non-specific DNA binding site [nucleotide binding]; other site 114615002367 salt bridge; other site 114615002368 sequence-specific DNA binding site [nucleotide binding]; other site 114615002369 Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5-; Region: TMP_TenI; cd00564 114615002370 pyrophosphate binding site [ion binding]; other site 114615002371 conjugal transfer relaxase TraA; Provisional; Region: PRK13889 114615002372 MobA/MobL family; Region: MobA_MobL; pfam03389 114615002373 AAA domain; Region: AAA_30; pfam13604 114615002374 Family description; Region: UvrD_C_2; pfam13538 114615002375 Conjugal transfer protein TraD; Region: TraD; pfam06412 114615002376 SIR2 superfamily of proteins includes silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein/histone deacetylation, where the acetyl group from the lysine epsilon-amino group is transferred to the ADP-ribose moiety of NAD+; Region: SIR2; cl00195 114615002377 SIR2-like domain; Region: SIR2_2; pfam13289 114615002378 Piwi_piwi-like_ProArk: PIWI domain, Piwi-like subfamily found in Archaea and Bacteria. RNA silencing refers to a group of related gene-silencing mechanisms mediated by short RNA molecules, including siRNAs, miRNAs, and heterochromatin-related guide RNAs; Region: Piwi_piwi-like_ProArk; cd04659 114615002379 5' RNA guide strand anchoring site; other site 114615002380 active site 114615002381 Type I restriction enzyme R protein N terminus (HSDR_N); Region: HSDR_N; cl14958 114615002382 Domain of unknown function (DUF4365); Region: DUF4365; pfam14280 114615002383 Peptidase S8 family domain, uncharacterized subfamily 12; Region: Peptidases_S8_12; cd07480 114615002384 active site 114615002385 catalytic triad [active] 114615002386 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 114615002387 active site 114615002388 Int/Topo IB signature motif; other site 114615002389 Histidinol-phosphate/aromatic aminotransferase and cobyric acid decarboxylase [Amino acid transport and metabolism]; Region: HisC; COG0079 114615002390 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 114615002391 pyridoxal 5'-phosphate binding site [chemical binding]; other site 114615002392 homodimer interface [polypeptide binding]; other site 114615002393 catalytic residue [active] 114615002394 chemotaxis-specific methylesterase; Provisional; Region: PRK00742 114615002395 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 114615002396 active site 114615002397 phosphorylation site [posttranslational modification] 114615002398 intermolecular recognition site; other site 114615002399 dimerization interface [polypeptide binding]; other site 114615002400 CheB methylesterase; Region: CheB_methylest; pfam01339 114615002401 CheR methyltransferase, all-alpha domain; Region: CheR_N; pfam03705 114615002402 Methyltransferase, chemotaxis proteins; Region: MeTrc; smart00138 114615002403 CheR methyltransferase, SAM binding domain; Region: CheR; pfam01739 114615002404 CheW, a small regulator protein, unique to the chemotaxis signalling in prokaryotes and archea. CheW interacts with the histidine kinase CheA, most likely with the related regulatory domain of CheA. CheW is proposed to form signalling arrays together...; Region: CheW; cd00732 114615002405 putative CheA interaction surface; other site 114615002406 Four helix bundle sensory module for signal transduction; Region: 4HB_MCP_1; pfam12729 114615002407 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 114615002408 dimerization interface [polypeptide binding]; other site 114615002409 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 114615002410 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 114615002411 dimer interface [polypeptide binding]; other site 114615002412 putative CheW interface [polypeptide binding]; other site 114615002413 Four helix bundle sensory module for signal transduction; Region: 4HB_MCP_1; pfam12729 114615002414 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 114615002415 dimerization interface [polypeptide binding]; other site 114615002416 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 114615002417 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 114615002418 dimer interface [polypeptide binding]; other site 114615002419 putative CheW interface [polypeptide binding]; other site 114615002420 CheW-like domain. CheW proteins are part of the chemotaxis signalling mechanism in bacteria. CheW interacts with the methyl accepting chemotaxis proteins (MCPs) and relays signals to CheY, which affects flageller rotation. This family includes CheW and...; Region: CheW_like; cl00256 114615002421 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 114615002422 Chemotaxis protein histidine kinase and related kinases [Cell motility and secretion / Signal transduction mechanisms]; Region: CheA; COG0643 114615002423 putative binding surface; other site 114615002424 active site 114615002425 Signal transducing histidine kinase, homodimeric domain; Region: H-kinase_dim; pfam02895 114615002426 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 114615002427 ATP binding site [chemical binding]; other site 114615002428 Mg2+ binding site [ion binding]; other site 114615002429 G-X-G motif; other site 114615002430 CheA regulatory domain; CheA is a histidine protein kinase present in bacteria and archea. Activated by the chemotaxis receptor a histidine phosphoryl group from CheA is passed directly to an aspartate in the response regulator CheY. This signalling...; Region: CheA_reg; cd00731 114615002431 STAS domain; Region: STAS_2; pfam13466 114615002432 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057 114615002433 metal ion-dependent adhesion site (MIDAS); other site 114615002434 TIGR04222 domain; Region: near_uncomplex 114615002435 Uncharacterized conserved protein [Function unknown]; Region: COG4278 114615002436 Peptidase family M48; Region: Peptidase_M48; cl12018 114615002437 VWA domain containing CoxE-like protein; Region: VWA_CoxE; pfam05762 114615002438 VWA YIEM type: Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b...; Region: VWA_YIEM_type; cd01462 114615002439 metal ion-dependent adhesion site (MIDAS); other site 114615002440 MoxR-like ATPases [General function prediction only]; Region: COG0714 114615002441 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 114615002442 Walker A motif; other site 114615002443 ATP binding site [chemical binding]; other site 114615002444 Walker B motif; other site 114615002445 arginine finger; other site 114615002446 SWIM zinc finger; Region: SWIM; pfam04434 114615002447 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; pfam13231 114615002448 TRAP transporter solute receptor, TAXI family; Region: TRAP_TAXI; TIGR02122 114615002449 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 114615002450 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 114615002451 active site 114615002452 catalytic tetrad [active] 114615002453 hypothetical protein; Provisional; Region: PRK01254 114615002454 Radical SAM N-terminal; Region: Radical_SAM_N; pfam08497 114615002455 Domain of unknown function (DUF3362); Region: DUF3362; pfam11842 114615002456 haloacid dehalogenase-like hydrolase family protein; Region: PLN02770 114615002457 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 114615002458 motif II; other site 114615002459 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2268 114615002460 SPFH domain / Band 7 family; Region: Band_7; pfam01145 114615002461 GMP synthase - Glutamine amidotransferase domain [Nucleotide transport and metabolism]; Region: GuaA; COG0518 114615002462 Subgroup of proteins having the Type 1 glutamine amidotransferase (GATase1) domain; Region: GATase1_1; cd01741 114615002463 catalytic triad [active] 114615002464 Putative effector of murein hydrolase [Cell envelope biogenesis, outer membrane]; Region: LrgB; COG1346 114615002465 LrgA family; Region: LrgA; cl00608 114615002466 Transcriptional regulator [Transcription]; Region: LysR; COG0583 114615002467 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 114615002468 The C-terminal substrate binding domain of LysR-like transcriptional regulator CidR, contains the type 2 periplasmic binding fold; Region: PBP2_CidR; cd08438 114615002469 putative dimerization interface [polypeptide binding]; other site 114615002470 ergothioneine biosynthesis protein EgtC; Region: TIGR03442 114615002471 Glutamine amidotransferases class-II (Gn-AT)_YafJ-type. YafJ is a glutamine amidotransferase-like protein of unknown function found in prokaryotes, eukaryotes and archaea. YafJ has a conserved structural fold similar to those of other class II...; Region: YafJ; cd01908 114615002472 putative active site [active] 114615002473 putative dimer interface [polypeptide binding]; other site 114615002474 asparagine synthase family amidotransferase; Region: trio_amidotrans; TIGR03104 114615002475 Glutamine amidotransferases class-II (GATase) asparagine synthase_B type. Asparagine synthetase B catalyses the ATP-dependent conversion of aspartate to asparagine. This enzyme is a homodimer, with each monomer composed of a glutaminase domain and a...; Region: AsnB; cd00712 114615002476 active site 114615002477 dimer interface [polypeptide binding]; other site 114615002478 The C-terminal domain of Asparagine Synthase B. This domain is always found associated n-terminal amidotransferase domain. Family members that contain this domain catalyse the conversion of aspartate to asparagine. Asparagine synthetase B catalyzes the...; Region: Asn_Synthase_B_C; cd01991 114615002479 Ligand Binding Site [chemical binding]; other site 114615002480 Molecular Tunnel; other site 114615002481 carboxylate-amine ligase; Provisional; Region: PRK13515 114615002482 carboxylate-amine ligase, YbdK family; Region: gshA_cyan_rel; TIGR02050 114615002483 cytosine deaminase; Provisional; Region: PRK05985 114615002484 Bacterial cytosine deaminase and related metal-dependent hydrolases. Cytosine deaminases (CDs) catalyze the deamination of cytosine, producing uracil and ammonia. They play an important role in pyrimidine salvage. CDs are present in prokaryotes and fungi; Region: Bact_CD; cd01293 114615002485 active site 114615002486 Predicted esterase [General function prediction only]; Region: COG0400 114615002487 putative hydrolase; Provisional; Region: PRK11460 114615002488 N-terminal domain of Sphingobium chlorophenolicum 2,6-dichloro-p-hydroquinone 1,2-dioxygenase (PcpA), and similar proteins; Region: PcpA_N_like; cd08346 114615002489 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 114615002490 Zn binding site [ion binding]; other site 114615002491 C-terminal domain of Sphingobium chlorophenolicum 2,6-dichloro-p-hydroquinone 1,2-dioxygenase (PcpA), and similar proteins; Region: PcpA_C_like; cd08347 114615002492 Zn binding site [ion binding]; other site 114615002493 Transcriptional regulator [Transcription]; Region: LysR; COG0583 114615002494 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 114615002495 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 114615002496 putative effector binding pocket; other site 114615002497 dimerization interface [polypeptide binding]; other site 114615002498 HIUase (5-hydroxyisourate hydrolase) catalyzes the second step in a three-step ureide pathway in which 5-hydroxyisourate (HIU), a product of the uricase (urate oxidase) reaction, is hydrolyzed to 2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline (OHCU); Region: TLP_HIUase; cd05822 114615002499 active site 114615002500 homotetramer interface [polypeptide binding]; other site 114615002501 putative urate catabolism protein; Region: uraD_N-term-dom; TIGR03212 114615002502 Catalytic domain of bacterial PuuE allantoinases, Schizosaccharomyces pombe chitin deacetylase 1 (SpCDA1), and similar proteins; Region: CE4_PuuE_SpCDA1; cd10977 114615002503 active site 114615002504 catalytic site [active] 114615002505 tetramer interface [polypeptide binding]; other site 114615002506 OHCU decarboxylase; Region: OHCU_decarbox; pfam09349 114615002507 Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154 114615002508 Amidase; Region: Amidase; cl11426 114615002509 Major Facilitator Superfamily; Region: MFS_1; pfam07690 114615002510 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 114615002511 putative substrate translocation pore; other site 114615002512 HIUase (5-hydroxyisourate hydrolase) catalyzes the second step in a three-step ureide pathway in which 5-hydroxyisourate (HIU), a product of the uricase (urate oxidase) reaction, is hydrolyzed to 2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline (OHCU); Region: TLP_HIUase; cd05822 114615002513 active site 114615002514 homotetramer interface [polypeptide binding]; other site 114615002515 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 114615002516 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 114615002517 dimer interface [polypeptide binding]; other site 114615002518 conserved gate region; other site 114615002519 putative PBP binding loops; other site 114615002520 ABC-ATPase subunit interface; other site 114615002521 2-aminoethylphosphonate transport system permease PhnU; Provisional; Region: PRK15050 114615002522 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 114615002523 dimer interface [polypeptide binding]; other site 114615002524 conserved gate region; other site 114615002525 putative PBP binding loops; other site 114615002526 ABC-ATPase subunit interface; other site 114615002527 Spermidine/putrescine-binding periplasmic protein [Amino acid transport and metabolism]; Region: PotD; COG0687 114615002528 ABC-type Fe3+ transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: AfuA; COG1840 114615002529 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 114615002530 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 114615002531 Walker A/P-loop; other site 114615002532 ATP binding site [chemical binding]; other site 114615002533 Q-loop/lid; other site 114615002534 ABC transporter signature motif; other site 114615002535 Walker B; other site 114615002536 D-loop; other site 114615002537 H-loop/switch region; other site 114615002538 TOBE domain; Region: TOBE_2; pfam08402 114615002539 Asp/Glu/Hydantoin racemase; Region: Asp_Glu_race; cl00518 114615002540 Protein of unknown function (DUF3429); Region: DUF3429; pfam11911 114615002541 Uncharacterized protein conserved in bacteria (DUF2256); Region: DUF2256; pfam10013 114615002542 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 114615002543 NAD(P) binding site [chemical binding]; other site 114615002544 active site 114615002545 ABC-type Na+ transport system, ATPase component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatA; COG4555 114615002546 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 114615002547 Walker A/P-loop; other site 114615002548 ATP binding site [chemical binding]; other site 114615002549 Q-loop/lid; other site 114615002550 ABC transporter signature motif; other site 114615002551 Walker B; other site 114615002552 D-loop; other site 114615002553 H-loop/switch region; other site 114615002554 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 114615002555 Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220 114615002556 Beta-lactamase superfamily domain; Region: Lactamase_B_3; pfam13483 114615002557 Protein of unknown function (DUF861); Region: Cupin_3; cl17594 114615002558 Domain of unknown function (DUF4399); Region: DUF4399; pfam14347 114615002559 Leucyl aminopeptidase (aminopeptidase T) [Amino acid transport and metabolism]; Region: AmpS; COG2309 114615002560 Thermophilic metalloprotease (M29); Region: Peptidase_M29; pfam02073 114615002561 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 114615002562 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 114615002563 active site 114615002564 metal binding site [ion binding]; metal-binding site 114615002565 short chain dehydrogenase; Validated; Region: PRK08264 114615002566 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 114615002567 NAD(P) binding site [chemical binding]; other site 114615002568 active site 114615002569 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124 114615002570 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 114615002571 Walker A/P-loop; other site 114615002572 ATP binding site [chemical binding]; other site 114615002573 Q-loop/lid; other site 114615002574 ABC transporter signature motif; other site 114615002575 Walker B; other site 114615002576 D-loop; other site 114615002577 H-loop/switch region; other site 114615002578 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 114615002579 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 114615002580 nickel import ATP-binding protein NikD; Region: nickel_nikD; TIGR02770 114615002581 Walker A/P-loop; other site 114615002582 ATP binding site [chemical binding]; other site 114615002583 Q-loop/lid; other site 114615002584 ABC transporter signature motif; other site 114615002585 Walker B; other site 114615002586 D-loop; other site 114615002587 H-loop/switch region; other site 114615002588 nickel ABC transporter, permease subunit NikC; Region: nickel_nikC; TIGR02790 114615002589 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 114615002590 dimer interface [polypeptide binding]; other site 114615002591 conserved gate region; other site 114615002592 putative PBP binding loops; other site 114615002593 ABC-ATPase subunit interface; other site 114615002594 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 114615002595 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 114615002596 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cl01709 114615002597 Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496 114615002598 Dienelactone hydrolase and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG0412 114615002599 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109 114615002600 MarR family; Region: MarR_2; cl17246 114615002601 heavy metal efflux pump, CzcA family; Region: 2A0601; TIGR00914 114615002602 Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154 114615002603 Amidase; Region: Amidase; cl11426 114615002604 Bacterial transglutaminase-like cysteine proteinase BTLCP; Region: BTLCP; cl17596 114615002605 FecR protein; Region: FecR; pfam04773 114615002606 Domain of unknown function (DUF4353); Region: DUF4353; pfam14262 114615002607 VCBS repeat; Region: VCBS_repeat; TIGR01965 114615002608 CHASE2 domain; Region: CHASE2; pfam05226 114615002609 Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114 114615002610 cyclase homology domain; Region: CHD; cd07302 114615002611 nucleotidyl binding site; other site 114615002612 metal binding site [ion binding]; metal-binding site 114615002613 dimer interface [polypeptide binding]; other site 114615002614 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_8; cd08495 114615002615 Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496 114615002616 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 114615002617 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_8; cd08495 114615002618 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 114615002619 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 114615002620 dimer interface [polypeptide binding]; other site 114615002621 conserved gate region; other site 114615002622 putative PBP binding loops; other site 114615002623 ABC-ATPase subunit interface; other site 114615002624 nickel ABC transporter, permease subunit NikC; Region: nickel_nikC; TIGR02790 114615002625 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 114615002626 dimer interface [polypeptide binding]; other site 114615002627 conserved gate region; other site 114615002628 putative PBP binding loops; other site 114615002629 ABC-ATPase subunit interface; other site 114615002630 dipeptide transporter ATP-binding subunit; Provisional; Region: dppF; PRK11308 114615002631 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 114615002632 Walker A/P-loop; other site 114615002633 ATP binding site [chemical binding]; other site 114615002634 Q-loop/lid; other site 114615002635 ABC transporter signature motif; other site 114615002636 Walker B; other site 114615002637 D-loop; other site 114615002638 H-loop/switch region; other site 114615002639 oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727 114615002640 Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154 114615002641 Amidase; Region: Amidase; cl11426 114615002642 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 114615002643 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 114615002644 Walker A/P-loop; other site 114615002645 ATP binding site [chemical binding]; other site 114615002646 Q-loop/lid; other site 114615002647 ABC transporter signature motif; other site 114615002648 Walker B; other site 114615002649 D-loop; other site 114615002650 H-loop/switch region; other site 114615002651 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 114615002652 ABC-type protease/lipase transport system, ATPase and permease components [General function prediction only]; Region: ArpD; COG4618 114615002653 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 114615002654 ATP-binding cassette domain of PrtD, subfamily C; Region: ABCC_Protease_Secretion; cd03246 114615002655 Walker A/P-loop; other site 114615002656 ATP binding site [chemical binding]; other site 114615002657 Q-loop/lid; other site 114615002658 ABC transporter signature motif; other site 114615002659 Walker B; other site 114615002660 D-loop; other site 114615002661 H-loop/switch region; other site 114615002662 type I secretion membrane fusion protein, HlyD family; Region: type_I_hlyD; TIGR01843 114615002663 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 114615002664 HlyD family secretion protein; Region: HlyD_3; pfam13437 114615002665 Competence-damaged protein; Region: CinA; pfam02464 114615002666 citrate-proton symporter; Provisional; Region: PRK15075 114615002667 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 114615002668 putative substrate translocation pore; other site 114615002669 DNA-binding transcriptional activator GcvA; Provisional; Region: PRK11139 114615002670 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 114615002671 The C-terminal substrate domain of LysR-type GcdR, TrPI, HvR and beta-lactamase regulators, and that of other closely related homologs; contains the type 2 periplasmic binding fold; Region: PBP2_GcdR_TrpI_HvrB_AmpR_like; cd08432 114615002672 dimerization interface [polypeptide binding]; other site 114615002673 substrate binding pocket [chemical binding]; other site 114615002674 Uncharacterized conserved small protein [Function unknown]; Region: COG5457 114615002675 Short-chain alcohol dehydrogenase of unknown specificity [General function prediction only]; Region: COG4221 114615002676 classical (c) SDR, subgroup 10; Region: SDR_c10; cd05373 114615002677 putative NAD(P) binding site [chemical binding]; other site 114615002678 active site 114615002679 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 114615002680 Glutathione S-transferase, N-terminal domain; Region: GST_N_3; pfam13417 114615002681 C-terminal, alpha helical domain of the Glutathione S-transferase family; Region: GST_C_family; cd00299 114615002682 N-terminal domain interface [polypeptide binding]; other site 114615002683 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 114615002684 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 114615002685 active site 114615002686 Zn-dependent alcohol dehydrogenases, class III [Energy production and conversion]; Region: AdhC; COG1062 114615002687 Class III alcohol dehydrogenase; Region: Zn_ADH_class_III; cd08279 114615002688 NAD binding site [chemical binding]; other site 114615002689 catalytic Zn binding site [ion binding]; other site 114615002690 substrate binding site [chemical binding]; other site 114615002691 structural Zn binding site [ion binding]; other site 114615002692 amidase; Provisional; Region: PRK06170 114615002693 Amidase; Region: Amidase; cl11426 114615002694 Cytochrome B561 [Energy production and conversion]; Region: CybB; COG3038 114615002695 Uncharacterized family of ferritin-like proteins found in archaea and bacteria; Region: Ferritin_like_AB; cd01045 114615002696 diiron binding motif [ion binding]; other site 114615002697 Uncharacterized conserved protein [Function unknown]; Region: COG1633 114615002698 CCC1-related family of proteins; Region: CCC1_like; cl00278 114615002699 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 114615002700 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 114615002701 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 114615002702 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK08276 114615002703 Bacterial Bile acid CoA ligases and similar proteins; Region: BACL_like; cd05929 114615002704 acyl-activating enzyme (AAE) consensus motif; other site 114615002705 acyl-activating enzyme (AAE) consensus motif; other site 114615002706 putative AMP binding site [chemical binding]; other site 114615002707 putative active site [active] 114615002708 putative CoA binding site [chemical binding]; other site 114615002709 acetyl-CoA acetyltransferase; Provisional; Region: PRK06504 114615002710 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 114615002711 dimer interface [polypeptide binding]; other site 114615002712 active site 114615002713 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 114615002714 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 114615002715 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 114615002716 NAD(P) binding site [chemical binding]; other site 114615002717 active site 114615002718 enoyl-CoA hydratase; Provisional; Region: PRK06688 114615002719 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 114615002720 substrate binding site [chemical binding]; other site 114615002721 oxyanion hole (OAH) forming residues; other site 114615002722 trimer interface [polypeptide binding]; other site 114615002723 acyl-CoA synthetase; Provisional; Region: PRK12582 114615002724 Feruloyl-CoA synthetase (FCS); Region: FCS; cd05921 114615002725 acyl-activating enzyme (AAE) consensus motif; other site 114615002726 putative AMP binding site [chemical binding]; other site 114615002727 putative active site [active] 114615002728 putative CoA binding site [chemical binding]; other site 114615002729 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 114615002730 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 114615002731 active site 114615002732 Putative acyl-CoA dehydrogenases similar to fadE6, fadE17, and fadE26; Region: ACAD_fadE6_17_26; cd01152 114615002733 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 114615002734 FAD binding site [chemical binding]; other site 114615002735 substrate binding site [chemical binding]; other site 114615002736 catalytic base [active] 114615002737 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 114615002738 Putative acyl-CoA dehydrogenases similar to fadE6, fadE17, and fadE26; Region: ACAD_fadE6_17_26; cd01152 114615002739 FAD binding site [chemical binding]; other site 114615002740 substrate binding site [chemical binding]; other site 114615002741 catalytic base [active] 114615002742 Nitroreductase family. Members of this family utilize FMN as a cofactor and catalyze reduction of a variety of nitroaromatic compounds, including nitrofurans, nitrobenzens, nitrophenol, nitrobenzoate and quinones by using either NADH or NADPH as a source...; Region: Nitroreductase; cd02136 114615002743 putative FMN binding site [chemical binding]; other site 114615002744 Autoinducer synthetase; Region: Autoind_synth; cl17404 114615002745 Autoinducer binding domain; Region: Autoind_bind; pfam03472 114615002746 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 114615002747 DNA binding residues [nucleotide binding] 114615002748 Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024 114615002749 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 114615002750 substrate binding site [chemical binding]; other site 114615002751 oxyanion hole (OAH) forming residues; other site 114615002752 trimer interface [polypeptide binding]; other site 114615002753 Ion transport protein; Region: Ion_trans; pfam00520 114615002754 Ion channel; Region: Ion_trans_2; pfam07885 114615002755 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 114615002756 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 114615002757 ligand binding site [chemical binding]; other site 114615002758 flexible hinge region; other site 114615002759 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 114615002760 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 114615002761 ligand binding site [chemical binding]; other site 114615002762 flexible hinge region; other site 114615002763 putative indolepyruvate oxidoreductase subunit B; Reviewed; Region: PRK08312 114615002764 Protein of unknown function (DUF3307); Region: DUF3307; pfam11750 114615002765 Predicted Fe-S-cluster oxidoreductase [General function prediction only]; Region: COG0727 114615002766 Predicted transcriptional regulator [Transcription]; Region: COG2378 114615002767 HTH domain; Region: HTH_11; pfam08279 114615002768 WYL domain; Region: WYL; pfam13280 114615002769 GST_N family, Metaxin subfamily, Metaxin-like proteins; a heterogenous group of proteins, predominantly uncharacterized, with similarity to metaxins and GSTs. Metaxin 1 is a component of a preprotein import complex of the mitochondrial outer membrane. It...; Region: GST_N_Metaxin_like; cd03080 114615002770 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 114615002771 putative C-terminal domain interface [polypeptide binding]; other site 114615002772 putative GSH binding site [chemical binding]; other site 114615002773 putative dimer interface [polypeptide binding]; other site 114615002774 C-terminal, alpha helical domain of Metaxin and related proteins; Region: GST_C_Metaxin; cd03193 114615002775 putative N-terminal domain interface [polypeptide binding]; other site 114615002776 Pyridoxine 5'-phosphate (PNP) oxidase-like proteins; Region: PNPOx_like; cl00381 114615002777 transcriptional regulator; Provisional; Region: PRK10632 114615002778 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 114615002779 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_2; cd08471 114615002780 putative effector binding pocket; other site 114615002781 putative dimerization interface [polypeptide binding]; other site 114615002782 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 114615002783 CoenzymeA binding site [chemical binding]; other site 114615002784 subunit interaction site [polypeptide binding]; other site 114615002785 PHB binding site; other site 114615002786 TRAP-type C4-dicarboxylate transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: DctP; COG1638 114615002787 Bacterial extracellular solute-binding protein, family 7; Region: SBP_bac_7; cl15441 114615002788 Tripartite ATP-independent periplasmic transporters, DctQ component; Region: DctQ; pfam04290 114615002789 DctM-like transporters; Region: DctM; pfam06808 114615002790 TRAP-type C4-dicarboxylate transport system, large permease component [Carbohydrate transport and metabolism]; Region: DctQ; COG1593 114615002791 hypothetical protein; Provisional; Region: PRK00872 114615002792 Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024 114615002793 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 114615002794 substrate binding site [chemical binding]; other site 114615002795 oxyanion hole (OAH) forming residues; other site 114615002796 trimer interface [polypeptide binding]; other site 114615002797 feruloyl-CoA synthase; Reviewed; Region: PRK08180 114615002798 Feruloyl-CoA synthetase (FCS); Region: FCS; cd05921 114615002799 acyl-activating enzyme (AAE) consensus motif; other site 114615002800 putative AMP binding site [chemical binding]; other site 114615002801 putative active site [active] 114615002802 putative CoA binding site [chemical binding]; other site 114615002803 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 114615002804 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 114615002805 NAD(P) binding site [chemical binding]; other site 114615002806 active site 114615002807 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 114615002808 active site 114615002809 Type I periplasmic binding component of ABC (ATPase Binding Cassette)-type transport systems that are predicted to be involved in uptake of amino acids; Region: PBP1_ABC-type_HAAT_like; cd06333 114615002810 ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683 114615002811 putative ligand binding site [chemical binding]; other site 114615002812 Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501 114615002813 NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065 114615002814 shikimate binding site; other site 114615002815 NAD(P) binding site [chemical binding]; other site 114615002816 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410 114615002817 ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224 114615002818 Walker A/P-loop; other site 114615002819 ATP binding site [chemical binding]; other site 114615002820 Q-loop/lid; other site 114615002821 ABC transporter signature motif; other site 114615002822 Walker B; other site 114615002823 D-loop; other site 114615002824 H-loop/switch region; other site 114615002825 ABC-type branched-chain amino acid transport system, permease component [Amino acid transport and metabolism]; Region: LivM; COG4177 114615002826 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 114615002827 TM-ABC transporter signature motif; other site 114615002828 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411 114615002829 ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219 114615002830 Walker A/P-loop; other site 114615002831 ATP binding site [chemical binding]; other site 114615002832 Q-loop/lid; other site 114615002833 ABC transporter signature motif; other site 114615002834 Walker B; other site 114615002835 D-loop; other site 114615002836 H-loop/switch region; other site 114615002837 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 114615002838 TM-ABC transporter signature motif; other site 114615002839 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 114615002840 MarR family; Region: MarR; pfam01047 114615002841 Putative glycerate kinase [Carbohydrate transport and metabolism]; Region: GckA; COG2379 114615002842 Domain of unknown function (DUF4147); Region: DUF4147; pfam13660 114615002843 MOFRL family; Region: MOFRL; pfam05161 114615002844 Type I periplasmic ligand-binding domain of uncharacterized ABC (ATPase Binding Cassette)-type active transport systems that are predicted to be involved in uptake of amino acids, peptides, or inorganic ions; Region: PBP1_ABC_ligand_binding_like_8; cd06343 114615002845 Periplasmic binding protein; Region: Peripla_BP_6; pfam13458 114615002846 putative ligand binding site [chemical binding]; other site 114615002847 Type I periplasmic ligand-binding domain of uncharacterized ABC (ATPase Binding Cassette)-type active transport systems that are predicted to be involved in uptake of amino acids, peptides, or inorganic ions; Region: PBP1_ABC_ligand_binding_like_8; cd06343 114615002848 Periplasmic binding protein; Region: Peripla_BP_6; pfam13458 114615002849 putative ligand binding site [chemical binding]; other site 114615002850 ABC-type branched-chain amino acid transport system, permease component [Amino acid transport and metabolism]; Region: LivM; COG4177 114615002851 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 114615002852 TM-ABC transporter signature motif; other site 114615002853 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 114615002854 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 114615002855 TM-ABC transporter signature motif; other site 114615002856 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410 114615002857 ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224 114615002858 Walker A/P-loop; other site 114615002859 ATP binding site [chemical binding]; other site 114615002860 Q-loop/lid; other site 114615002861 ABC transporter signature motif; other site 114615002862 Walker B; other site 114615002863 D-loop; other site 114615002864 H-loop/switch region; other site 114615002865 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411 114615002866 ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219 114615002867 Walker A/P-loop; other site 114615002868 ATP binding site [chemical binding]; other site 114615002869 Q-loop/lid; other site 114615002870 ABC transporter signature motif; other site 114615002871 Walker B; other site 114615002872 D-loop; other site 114615002873 H-loop/switch region; other site 114615002874 Transcriptional regulator [Transcription]; Region: IclR; COG1414 114615002875 IclR helix-turn-helix domain; Region: HTH_IclR; pfam09339 114615002876 Bacterial transcriptional regulator; Region: IclR; pfam01614 114615002877 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 114615002878 multifunctional fatty acid oxidation complex subunit alpha; Reviewed; Region: fadJ; PRK11154 114615002879 substrate binding site [chemical binding]; other site 114615002880 oxyanion hole (OAH) forming residues; other site 114615002881 trimer interface [polypeptide binding]; other site 114615002882 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 114615002883 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 114615002884 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 114615002885 dicarboxylate--CoA ligase PimA; Region: pimA; TIGR03205 114615002886 Prokaryotic long-chain fatty acid CoA synthetases similar to Escherichia coli FadD; Region: FC-FACS_FadD_like; cd05936 114615002887 acyl-activating enzyme (AAE) consensus motif; other site 114615002888 putative AMP binding site [chemical binding]; other site 114615002889 putative active site [active] 114615002890 putative CoA binding site [chemical binding]; other site 114615002891 acetyl-CoA acetyltransferase; Provisional; Region: PRK07108 114615002892 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 114615002893 dimer interface [polypeptide binding]; other site 114615002894 active site 114615002895 pimeloyl-CoA dehydrogenase, large subunit; Region: pimC_large; TIGR03204 114615002896 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 114615002897 active site 114615002898 pimeloyl-CoA dehydrogenase, small subunit; Region: pimD_small; TIGR03203 114615002899 Acyl-CoA dehydrogenase; Region: ACAD; cd00567 114615002900 active site 114615002901 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK07231 114615002902 classical (c) SDRs; Region: SDR_c; cd05233 114615002903 NAD(P) binding site [chemical binding]; other site 114615002904 active site 114615002905 glycerol kinase; Provisional; Region: glpK; PRK00047 114615002906 Escherichia coli glycerol kinase-like proteins; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_EcGK_like; cd07786 114615002907 N- and C-terminal domain interface [polypeptide binding]; other site 114615002908 active site 114615002909 MgATP binding site [chemical binding]; other site 114615002910 catalytic site [active] 114615002911 metal binding site [ion binding]; metal-binding site 114615002912 glycerol binding site [chemical binding]; other site 114615002913 homotetramer interface [polypeptide binding]; other site 114615002914 homodimer interface [polypeptide binding]; other site 114615002915 FBP binding site [chemical binding]; other site 114615002916 protein IIAGlc interface [polypeptide binding]; other site 114615002917 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 114615002918 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 114615002919 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 114615002920 Coenzyme A binding pocket [chemical binding]; other site 114615002921 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 114615002922 Glutathione S-transferase (GST) family, N-terminal domain; a large, diverse group of cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of endogenous and xenobiotic...; Region: GST_N_family; cd00570 114615002923 C-terminal domain interface [polypeptide binding]; other site 114615002924 GSH binding site (G-site) [chemical binding]; other site 114615002925 dimer interface [polypeptide binding]; other site 114615002926 C-terminal, alpha helical domain of the Glutathione S-transferase family; Region: GST_C_family; cl02776 114615002927 N-terminal domain interface [polypeptide binding]; other site 114615002928 dimer interface [polypeptide binding]; other site 114615002929 substrate binding pocket (H-site) [chemical binding]; other site 114615002930 Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404 114615002931 Multidrug resistance efflux pump [Defense mechanisms]; Region: EmrA; COG1566 114615002932 HlyD family secretion protein; Region: HlyD_3; pfam13437 114615002933 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 114615002934 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 114615002935 Walker A/P-loop; other site 114615002936 ATP binding site [chemical binding]; other site 114615002937 Q-loop/lid; other site 114615002938 ABC transporter signature motif; other site 114615002939 Walker B; other site 114615002940 D-loop; other site 114615002941 H-loop/switch region; other site 114615002942 DevC protein; Region: devC; TIGR01185 114615002943 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 114615002944 FtsX-like permease family; Region: FtsX; pfam02687 114615002945 B12-dependent methionine synthase; Provisional; Region: metH; PRK09490 114615002946 Methionine synthase I (cobalamin-dependent), methyltransferase domain [Amino acid transport and metabolism]; Region: MetH; COG0646 114615002947 MeTr subgroup of pterin binding enzymes. This family includes cobalamin-dependent methyltransferases such as methyltetrahydrofolate, corrinoid iron-sulfur protein methyltransferase (MeTr) and methionine synthase (MetH). Cobalamin-dependent...; Region: MeTr; cd00740 114615002948 substrate binding pocket [chemical binding]; other site 114615002949 B12 binding domain of methionine synthase. This domain binds methylcobalamin, which it uses as an intermediate methyl carrier from methyltetrahydrofolate (CH3H4folate) to homocysteine (Hcy); Region: methionine_synthase_B12_BD; cd02069 114615002950 B12 binding site [chemical binding]; other site 114615002951 cobalt ligand [ion binding]; other site 114615002952 Vitamin B12 dependent methionine synthase, activation domain; Region: Met_synt_B12; pfam02965 114615002953 Methylenetetrahydrofolate reductase (MTHFR). 5,10-Methylenetetrahydrofolate is reduced to 5-methyltetrahydrofolate by methylenetetrahydrofolate reductase, a cytoplasmic, NAD(P)-dependent enzyme. 5-methyltetrahydrofolate is utilized by methionine synthase...; Region: MTHFR; cd00537 114615002954 FAD binding site [chemical binding]; other site 114615002955 luciferase family oxidoreductase, group 1; Region: oxido_grp_1; TIGR03558 114615002956 probable oxidoreductase, LLM family; Region: LLM_2I7G; TIGR03858 114615002957 biliverdin IX beta reductase (BVR-B, aka flavin reductase)-like proteins; atypical (a) SDRs; Region: BVR-B_like_SDR_a; cd05244 114615002958 NADH(P)-binding; Region: NAD_binding_10; pfam13460 114615002959 NAD binding site [chemical binding]; other site 114615002960 substrate binding site [chemical binding]; other site 114615002961 putative active site [active] 114615002962 LysR family transcriptional regulator; Provisional; Region: PRK14997 114615002963 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 114615002964 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 114615002965 dimerization interface [polypeptide binding]; other site 114615002966 prephenate dehydratase; Provisional; Region: PRK11899 114615002967 Prephenate dehydratase; Region: PDT; pfam00800 114615002968 C-terminal ACT domain of the bifunctional chorismate mutase-prephenate dehydratase (CM-PDT) enzyme and the prephenate dehydratase (PDT) enzyme; Region: ACT_CM-PDT; cd04905 114615002969 putative L-Phe binding site [chemical binding]; other site 114615002970 3-deoxy-manno-octulosonate cytidylyltransferase; Provisional; Region: PRK05450 114615002971 CMP-KDO synthetase catalyzes the activation of KDO which is an essential component of the lipopolysaccharide; Region: CMP-KDO-Synthetase; cd02517 114615002972 Ligand binding site; other site 114615002973 oligomer interface; other site 114615002974 Cytochrome c2 [Energy production and conversion]; Region: COG3474 114615002975 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 114615002976 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_14; cd08497 114615002977 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 114615002978 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_14; cd08497 114615002979 ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG4174 114615002980 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 114615002981 dimer interface [polypeptide binding]; other site 114615002982 conserved gate region; other site 114615002983 putative PBP binding loops; other site 114615002984 ABC-ATPase subunit interface; other site 114615002985 ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG4239 114615002986 N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911 114615002987 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 114615002988 dimer interface [polypeptide binding]; other site 114615002989 conserved gate region; other site 114615002990 ABC-ATPase subunit interface; other site 114615002991 ABC-type uncharacterized transport system, duplicated ATPase component [General function prediction only]; Region: COG4172 114615002992 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 114615002993 Walker A/P-loop; other site 114615002994 ATP binding site [chemical binding]; other site 114615002995 Q-loop/lid; other site 114615002996 ABC transporter signature motif; other site 114615002997 Walker B; other site 114615002998 D-loop; other site 114615002999 H-loop/switch region; other site 114615003000 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 114615003001 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 114615003002 Walker A/P-loop; other site 114615003003 ATP binding site [chemical binding]; other site 114615003004 Q-loop/lid; other site 114615003005 ABC transporter signature motif; other site 114615003006 Walker B; other site 114615003007 D-loop; other site 114615003008 H-loop/switch region; other site 114615003009 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 114615003010 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 114615003011 NlpC/P60 family; Region: NLPC_P60; cl17555 114615003012 Leucyl aminopeptidase [Amino acid transport and metabolism]; Region: PepB; COG0260 114615003013 Cytosol aminopeptidase family, N-terminal and catalytic domains. Family M17 contains zinc- and manganese-dependent exopeptidases ( EC 3.4.11.1), including leucine aminopeptidase. They catalyze removal of amino acids from the N-terminus of a protein and...; Region: Peptidase_M17; cd00433 114615003014 interface (dimer of trimers) [polypeptide binding]; other site 114615003015 Substrate-binding/catalytic site; other site 114615003016 Zn-binding sites [ion binding]; other site 114615003017 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 114615003018 TPR motif; other site 114615003019 TPR repeat; Region: TPR_11; pfam13414 114615003020 binding surface 114615003021 Tetratricopeptide repeat; Region: TPR_12; pfam13424 114615003022 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 114615003023 TPR motif; other site 114615003024 binding surface 114615003025 TPR repeat; Region: TPR_11; pfam13414 114615003026 allantoate amidohydrolase; Reviewed; Region: PRK12892 114615003027 M20 Peptidase beta-alanine synthase, an amidohydrolase; Region: M20_bAS; cd03884 114615003028 active site 114615003029 metal binding site [ion binding]; metal-binding site 114615003030 dimer interface [polypeptide binding]; other site 114615003031 Flp pilus assembly protein TadC [Cell motility and secretion / Intracellular trafficking and secretion]; Region: TadC; COG2064 114615003032 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 114615003033 Flp pilus assembly protein TadB [Intracellular trafficking and secretion]; Region: TadB; COG4965 114615003034 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 114615003035 Flp pilus assembly protein, ATPase CpaF [Intracellular trafficking and secretion]; Region: CpaF; COG4962 114615003036 Type IV secretory pathway component VirB11, and related ATPases. The homohexamer, VirB11 is one of eleven Vir proteins, which are required for T-pilus biogenesis and virulence in the transfer of T-DNA from the Ti (tumor-inducing) plasmid of bacterial to...; Region: VirB11-like_ATPase; cd01130 114615003037 ATP binding site [chemical binding]; other site 114615003038 Walker A motif; other site 114615003039 hexamer interface [polypeptide binding]; other site 114615003040 Walker B motif; other site 114615003041 Antiactivator of flagellar biosynthesis FleN, an ATPase [Cell motility]; Region: flhG; COG0455 114615003042 This protein family consists of proteins similar to the cpaE protein of the Caulobacter pilus assembly and the orf4 protein of Actinobacillus pilus formation gene cluster. The function of these proteins are unkown. The Caulobacter pilus assembly contains...; Region: CpaE_like; cd03111 114615003043 This protein family consists of proteins similar to the cpaE protein of the Caulobacter pilus assembly and the orf4 protein of Actinobacillus pilus formation gene cluster. The function of these proteins are unkown. The Caulobacter pilus assembly contains...; Region: CpaE_like; cd03111 114615003044 Type IV pili component [Cell motility and secretion]; Region: COG5461 114615003045 Pilus biogenesis CpaD protein (pilus_cpaD); Region: Pilus_CpaD; pfam09476 114615003046 Pilus formation protein N terminal region; Region: T2SS-T3SS_pil_N; pfam13629 114615003047 Flp pilus assembly protein, secretin CpaC [Intracellular trafficking and secretion]; Region: CpaC; COG4964 114615003048 Bacterial type II and III secretion system protein; Region: Secretin; pfam00263 114615003049 Flp pilus assembly protein CpaB [Intracellular trafficking and secretion]; Region: CpaB; COG3745 114615003050 SAF domains of the flagella basal body P-ring formation protein FlgA and the flp pilus assembly CpaB; Region: SAF_CpaB_FlgA_like; cd11614 114615003051 Flp pilus assembly protein, protease CpaA [Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: CpaA; COG4960 114615003052 Sterol desaturase [Lipid metabolism]; Region: ERG3; COG3000 114615003053 Fatty acid hydroxylase superfamily; Region: FA_hydroxylase; pfam04116 114615003054 Pilus formation protein N terminal region; Region: T2SS-T3SS_pil_N; pfam13629 114615003055 TadE-like protein; Region: TadE; pfam07811 114615003056 Flp pilus assembly protein TadG [Intracellular trafficking and secretion]; Region: TadG; COG4961 114615003057 TadE-like protein; Region: TadE; pfam07811 114615003058 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 114615003059 DNA-binding site [nucleotide binding]; DNA binding site 114615003060 RNA-binding motif; other site 114615003061 S1_IF1: Translation Initiation Factor IF1, S1-like RNA-binding domain. IF1 contains an S1-like RNA-binding domain, which is found in a wide variety of RNA-associated proteins. Translation initiation includes a number of interrelated steps preceding the...; Region: S1_IF1; cd04451 114615003062 rRNA binding site [nucleotide binding]; other site 114615003063 predicted 30S ribosome binding site; other site 114615003064 ATP-dependent RNA helicase RhlE; Provisional; Region: PRK10590 114615003065 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 114615003066 ATP binding site [chemical binding]; other site 114615003067 Mg++ binding site [ion binding]; other site 114615003068 motif III; other site 114615003069 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 114615003070 nucleotide binding region [chemical binding]; other site 114615003071 ATP-binding site [chemical binding]; other site 114615003072 Periplasmic binding protein; Region: Peripla_BP_6; pfam13458 114615003073 Periplasmic component (FmdD) of an active transport system for short-chain amides and urea (FmdDEF); Region: PBP1_FmdD_like; cd06355 114615003074 putative ligand binding site [chemical binding]; other site 114615003075 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 114615003076 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 114615003077 TM-ABC transporter signature motif; other site 114615003078 ABC-type branched-chain amino acid transport system, permease component [Amino acid transport and metabolism]; Region: LivM; COG4177 114615003079 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 114615003080 TM-ABC transporter signature motif; other site 114615003081 urea ABC transporter, ATP-binding protein UrtD; Region: urea_trans_UrtD; TIGR03411 114615003082 ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219 114615003083 Walker A/P-loop; other site 114615003084 ATP binding site [chemical binding]; other site 114615003085 Q-loop/lid; other site 114615003086 ABC transporter signature motif; other site 114615003087 Walker B; other site 114615003088 D-loop; other site 114615003089 H-loop/switch region; other site 114615003090 urea ABC transporter, ATP-binding protein UrtE; Region: urea_trans_UrtE; TIGR03410 114615003091 ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224 114615003092 Walker A/P-loop; other site 114615003093 ATP binding site [chemical binding]; other site 114615003094 Q-loop/lid; other site 114615003095 ABC transporter signature motif; other site 114615003096 Walker B; other site 114615003097 D-loop; other site 114615003098 H-loop/switch region; other site 114615003099 UreD urease accessory protein; Region: UreD; pfam01774 114615003100 Urease gamma-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, archaea, fungi and plants. Their primary role is to allow the use...; Region: Urease_gamma; cd00390 114615003101 alpha-gamma subunit interface [polypeptide binding]; other site 114615003102 beta-gamma subunit interface [polypeptide binding]; other site 114615003103 Urease beta-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, archaea, fungi and plants. Their primary role is to allow the use of...; Region: Urease_beta; cd00407 114615003104 gamma-beta subunit interface [polypeptide binding]; other site 114615003105 alpha-beta subunit interface [polypeptide binding]; other site 114615003106 HD domain; Region: HD_4; pfam13328 114615003107 urease subunit alpha; Reviewed; Region: ureC; PRK13207 114615003108 Urease alpha-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, fungi and plants. Their primary role is to allow the use of...; Region: Urease_alpha; cd00375 114615003109 subunit interactions [polypeptide binding]; other site 114615003110 active site 114615003111 flap region; other site 114615003112 Uncharacterized conserved protein [Function unknown]; Region: COG1359 114615003113 urease accessory protein UreE; Provisional; Region: ureE; PRK13261 114615003114 UreE urease accessory protein. UreE is a metallochaperone assisting the insertion of a Ni2+ ion in the active site of urease, an important step in the in vivo assembly of urease, an enzyme that hydrolyses urea into ammonia and carbamic acid. The...; Region: UreE; cd00571 114615003115 dimer interface [polypeptide binding]; other site 114615003116 catalytic residues [active] 114615003117 Urease accessory protein UreF [Posttranslational modification, protein turnover, chaperones]; Region: UreF; COG0830 114615003118 UreF; Region: UreF; pfam01730 114615003119 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 114615003120 This domain is found in the extracellular portion of receptor-like proteins - such as serine/threonine kinases and adenylyl cyclases; Region: CHASE; smart01079 114615003121 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920 114615003122 HWE histidine kinase; Region: HWE_HK; pfam07536 114615003123 RNA polymerase sigma factor; Provisional; Region: PRK12540 114615003124 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 114615003125 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 114615003126 DNA binding residues [nucleotide binding] 114615003127 two-component response regulator; Provisional; Region: PRK09191 114615003128 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 114615003129 active site 114615003130 phosphorylation site [posttranslational modification] 114615003131 intermolecular recognition site; other site 114615003132 dimerization interface [polypeptide binding]; other site 114615003133 Periplasmic protein TonB, links inner and outer membranes [Cell envelope biogenesis, outer membrane]; Region: TonB; COG0810 114615003134 TonB family C-terminal domain; Region: tonB_Cterm; TIGR01352 114615003135 Bacterial protein of unknown function (DUF883); Region: DUF883; pfam05957 114615003136 Domain of unknown function DUF20; Region: UPF0118; pfam01594 114615003137 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 114615003138 Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376 114615003139 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 114615003140 Protein of unknown function (DUF2865); Region: DUF2865; pfam11064 114615003141 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 114615003142 dimerization interface [polypeptide binding]; other site 114615003143 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 114615003144 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 114615003145 dimer interface [polypeptide binding]; other site 114615003146 putative CheW interface [polypeptide binding]; other site 114615003147 malate synthase G; Provisional; Region: PRK02999 114615003148 active site 114615003149 Predicted periplasmic protein [Function unknown]; Region: COG3904 114615003150 tryptophan tryptophylquinone biosynthesis enzyme MauG; Region: TTQ_mauG; TIGR03791 114615003151 Cytochrome c; Region: Cytochrom_C; pfam00034 114615003152 CysN, together with protein CysD, forms the ATP sulfurylase (ATPS) complex; Region: CysN_ATPS; cd04166 114615003153 bifunctional sulfate adenylyltransferase subunit 1/adenylylsulfate kinase protein; Provisional; Region: PRK05506 114615003154 G1 box; other site 114615003155 putative GEF interaction site [polypeptide binding]; other site 114615003156 GTP/Mg2+ binding site [chemical binding]; other site 114615003157 Switch I region; other site 114615003158 G2 box; other site 114615003159 CysD dimerization site [polypeptide binding]; other site 114615003160 G3 box; other site 114615003161 Switch II region; other site 114615003162 G4 box; other site 114615003163 G5 box; other site 114615003164 CysN_NodQ_II: This subfamily represents the domain II of the large subunit of ATP sulfurylase (ATPS): CysN or the N-terminal portion of NodQ, found mainly in proteobacteria and homologous to the domain II of EF-Tu. Escherichia coli ATPS consists of CysN...; Region: CysN_NodQ_II; cd03695 114615003165 TCysN_NoDQ_II: This subfamily represents the domain II of the large subunit of ATP sulfurylase (ATPS): CysN or the N-terminal portion of NodQ, found mainly in proteobacteria and homologous to the domain II of EF-Tu. Escherichia coli ATPS consists of CysN...; Region: CysN_NoDQ_III; cd04095 114615003166 Adenosine 5'-phosphosulfate kinase (APSK) catalyzes the phosphorylation of adenosine 5'-phosphosulfate to form 3'-phosphoadenosine 5'-phosphosulfate (PAPS). The end-product PAPS is a biologically "activated" sulfate form...; Region: APSK; cd02027 114615003167 ligand-binding site [chemical binding]; other site 114615003168 sulfate adenylyltransferase, small subunit; Region: CysD; TIGR02039 114615003169 This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713 114615003170 Active Sites [active] 114615003171 siroheme synthase; Provisional; Region: cysG; PRK10637 114615003172 Putative NAD(P)-binding; Region: NAD_binding_7; pfam13241 114615003173 Putative NAD(P)-binding; Region: NAD_binding_7; cl17660 114615003174 Sirohaem synthase dimerisation region; Region: CysG_dimeriser; pfam10414 114615003175 Uroporphyrin-III C-methyltransferase (S-Adenosyl-L-methionine:uroporphyrinogen III methyltransferase, SUMT); Region: SUMT; cd11642 114615003176 active site 114615003177 SAM binding site [chemical binding]; other site 114615003178 homodimer interface [polypeptide binding]; other site 114615003179 Protein of unknown function (DUF2849); Region: DUF2849; pfam11011 114615003180 Sulfite reductase, beta subunit (hemoprotein) [Inorganic ion transport and metabolism]; Region: CysI; COG0155 114615003181 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 114615003182 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 114615003183 Bacterial protein of unknown function (DUF934); Region: DUF934; pfam06073 114615003184 3'-phosphoadenosine 5'-phosphosulfate sulfotransferase (PAPS reductase)/FAD synthetase and related enzymes [Amino acid transport and metabolism / Coenzyme metabolism]; Region: CysH; COG0175 114615003185 This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713 114615003186 Active Sites [active] 114615003187 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 114615003188 Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531 114615003189 substrate binding pocket [chemical binding]; other site 114615003190 membrane-bound complex binding site; other site 114615003191 ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555 114615003192 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 114615003193 dimer interface [polypeptide binding]; other site 114615003194 conserved gate region; other site 114615003195 putative PBP binding loops; other site 114615003196 ABC-ATPase subunit interface; other site 114615003197 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 114615003198 dimer interface [polypeptide binding]; other site 114615003199 conserved gate region; other site 114615003200 putative PBP binding loops; other site 114615003201 ABC-ATPase subunit interface; other site 114615003202 ABC-type sulfate/molybdate transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: CysA; COG1118 114615003203 ATP-binding cassette domain of the sulfate transporter; Region: ABC_CysA_sulfate_importer; cd03296 114615003204 Walker A/P-loop; other site 114615003205 ATP binding site [chemical binding]; other site 114615003206 Q-loop/lid; other site 114615003207 ABC transporter signature motif; other site 114615003208 Walker B; other site 114615003209 D-loop; other site 114615003210 H-loop/switch region; other site 114615003211 TOBE-like domain; Region: TOBE_3; pfam12857 114615003212 SCP_bacterial: SCP-like extracellular protein domain, as found in bacteria and archaea. The wider family of SCP containing proteins includes plant pathogenesis-related protein 1 (PR-1), CRISPs, mammalian cysteine-rich secretory proteins, and allergen 5...; Region: SCP_bacterial; cd05379 114615003213 Predicted esterase of the alpha-beta hydrolase superfamily [General function prediction only]; Region: RssA; COG1752 114615003214 Hypothetical patatin similar to Z1214 protein of Escherichia coli; Region: Pat_hypo_Ecoli_Z1214_like; cd07209 114615003215 active site 114615003216 nucleophile elbow; other site 114615003217 Patatin phospholipase; Region: DUF3734; pfam12536 114615003218 d-3-hydroxybutyrate dehydrogenase (HBDH), classical (c) SDRs; Region: HBDH_SDR_c; cd08940 114615003219 3-hydroxybutyrate dehydrogenase; Region: PHB_DH; TIGR01963 114615003220 NAD binding site [chemical binding]; other site 114615003221 homotetramer interface [polypeptide binding]; other site 114615003222 homodimer interface [polypeptide binding]; other site 114615003223 substrate binding site [chemical binding]; other site 114615003224 active site 114615003225 Uncharacterized conserved protein [Function unknown]; Region: COG4095 114615003226 Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376 114615003227 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 114615003228 Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244 114615003229 Wzx, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_Wzx_like; cd13128 114615003230 Disulphide bond corrector protein DsbC; Region: DsbC; cl15830 114615003231 hypothetical protein; Validated; Region: PRK00228 114615003232 Probable taurine catabolism dioxygenase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: TauD; COG2175 114615003233 Taurine catabolism dioxygenase TauD, TfdA family; Region: TauD; pfam02668 114615003234 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 114615003235 classical (c) SDRs; Region: SDR_c; cd05233 114615003236 NAD(P) binding site [chemical binding]; other site 114615003237 active site 114615003238 dehydrogenase, PQQ-dependent, s-GDH family; Region: non_repeat_PQQ; TIGR03606 114615003239 Glucose / Sorbosone dehydrogenase; Region: GSDH; pfam07995 114615003240 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: FabG; COG1028 114615003241 classical (c) SDRs; Region: SDR_c; cd05233 114615003242 NAD(P) binding site [chemical binding]; other site 114615003243 active site 114615003244 CsbD-like; Region: CsbD; pfam05532 114615003245 Bacterial protein of unknown function (DUF883); Region: DUF883; cl01888 114615003246 SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cl01053 114615003247 active site 114615003248 oxyanion hole [active] 114615003249 SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cl01053 114615003250 catalytic triad [active] 114615003251 Transglycosylase SLT domain; Region: SLT_2; pfam13406 114615003252 murein hydrolase B; Provisional; Region: PRK10760; cl17906 114615003253 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 114615003254 Prokaryotic UGPase catalyses the synthesis of UDP-glucose; Region: UGPase_prokaryotic; cd02541 114615003255 dTDP-glucose pyrophosphorylase [Cell envelope biogenesis, outer membrane]; Region: RfbA; COG1209 114615003256 active site 114615003257 tetramer interface; other site 114615003258 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 114615003259 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 114615003260 metal binding site [ion binding]; metal-binding site 114615003261 active site 114615003262 I-site; other site 114615003263 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 114615003264 The substrate-binding component of ABC-type thermophilic oligopeptide-binding protein Hb8-like import systems, contains the type 2 periplasmic binding fold; Region: PBP2_thermophilic_Hb8_like; cd08513 114615003265 peptide binding site [polypeptide binding]; other site 114615003266 dimer interface [polypeptide binding]; other site 114615003267 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 114615003268 The substrate-binding component of ABC-type thermophilic oligopeptide-binding protein Hb8-like import systems, contains the type 2 periplasmic binding fold; Region: PBP2_thermophilic_Hb8_like; cd08513 114615003269 peptide binding site [polypeptide binding]; other site 114615003270 dimer interface [polypeptide binding]; other site 114615003271 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 114615003272 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 114615003273 dimer interface [polypeptide binding]; other site 114615003274 conserved gate region; other site 114615003275 putative PBP binding loops; other site 114615003276 ABC-ATPase subunit interface; other site 114615003277 nickel ABC transporter, permease subunit NikC; Region: nickel_nikC; TIGR02790 114615003278 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 114615003279 dimer interface [polypeptide binding]; other site 114615003280 conserved gate region; other site 114615003281 putative PBP binding loops; other site 114615003282 ABC-ATPase subunit interface; other site 114615003283 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 114615003284 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 114615003285 Walker A/P-loop; other site 114615003286 ATP binding site [chemical binding]; other site 114615003287 Q-loop/lid; other site 114615003288 ABC transporter signature motif; other site 114615003289 Walker B; other site 114615003290 D-loop; other site 114615003291 H-loop/switch region; other site 114615003292 oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727 114615003293 dipeptide transporter ATP-binding subunit; Provisional; Region: dppF; PRK11308 114615003294 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 114615003295 Walker A/P-loop; other site 114615003296 ATP binding site [chemical binding]; other site 114615003297 Q-loop/lid; other site 114615003298 ABC transporter signature motif; other site 114615003299 Walker B; other site 114615003300 D-loop; other site 114615003301 H-loop/switch region; other site 114615003302 oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727 114615003303 Cache is an extracellular domain that is predicted to have a role in small-molecule recognition in a wide range of proteins; Region: Cache_2; smart01049 114615003304 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 114615003305 dimer interface [polypeptide binding]; other site 114615003306 putative CheW interface [polypeptide binding]; other site 114615003307 PilZ domain; Region: PilZ; pfam07238 114615003308 feruloyl-CoA synthase; Reviewed; Region: PRK08180 114615003309 Feruloyl-CoA synthetase (FCS); Region: FCS; cd05921 114615003310 acyl-activating enzyme (AAE) consensus motif; other site 114615003311 putative AMP binding site [chemical binding]; other site 114615003312 putative active site [active] 114615003313 putative CoA binding site [chemical binding]; other site 114615003314 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 114615003315 MarR family; Region: MarR; pfam01047 114615003316 7TMR-DISM extracellular 2; Region: 7TMR-DISMED2; pfam07696 114615003317 7TM diverse intracellular signalling; Region: 7TMR-DISM_7TM; pfam07695 114615003318 Predicted acyltransferases [Lipid metabolism]; Region: COG1835 114615003319 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 114615003320 PAS fold; Region: PAS_3; pfam08447 114615003321 putative active site [active] 114615003322 heme pocket [chemical binding]; other site 114615003323 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 114615003324 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 114615003325 metal binding site [ion binding]; metal-binding site 114615003326 active site 114615003327 I-site; other site 114615003328 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 114615003329 putative NAD(P)H quinone oxidoreductase, PIG3 family; Region: quinone_pig3; TIGR02824 114615003330 PIG3 p53-inducible quinone oxidoreductase; Region: p53_inducible_oxidoreductase; cd05276 114615003331 NAD(P) binding site [chemical binding]; other site 114615003332 Protein of unknown function (DUF1192); Region: DUF1192; pfam06698 114615003333 Protein of unknown function (DUF1465); Region: DUF1465; pfam07323 114615003334 50S ribosomal protein L31; Reviewed; Region: rpmE; PRK00528 114615003335 ABC transporter, permease/ATP-binding protein; Region: MsbA_rel; TIGR02204 114615003336 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 114615003337 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 114615003338 Walker A/P-loop; other site 114615003339 ATP binding site [chemical binding]; other site 114615003340 Q-loop/lid; other site 114615003341 ABC transporter signature motif; other site 114615003342 Walker B; other site 114615003343 D-loop; other site 114615003344 H-loop/switch region; other site 114615003345 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 114615003346 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 114615003347 Coenzyme A binding pocket [chemical binding]; other site 114615003348 hypothetical protein; Validated; Region: PRK09039 114615003349 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 114615003350 ligand binding site [chemical binding]; other site 114615003351 Protein of unknown function (DUF1295); Region: DUF1295; cl17837 114615003352 Cyclopropane fatty acid synthase and related methyltransferases [Cell envelope biogenesis, outer membrane]; Region: Cfa; COG2230 114615003353 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 114615003354 S-adenosylmethionine binding site [chemical binding]; other site 114615003355 periplasmic multidrug efflux lipoprotein precursor; Reviewed; Region: PRK09578 114615003356 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 114615003357 HlyD family secretion protein; Region: HlyD_3; pfam13437 114615003358 The (Largely Gram-negative Bacterial) Hydrophobe/Amphiphile Efflux-1 (HAE1) Family; Region: 2A0602; TIGR00915 114615003359 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483 114615003360 IMPase, inositol monophosphatase and related domains. A family of Mg++ dependent phosphatases, inhibited by lithium, many of which may act on inositol monophosphate substrate. They dephosphorylate inositol phosphate to generate inositol, which may be...; Region: IMPase; cd01639 114615003361 active site 114615003362 dimerization interface [polypeptide binding]; other site 114615003363 FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790 114615003364 Sel1-like repeats; Region: SEL1; smart00671 114615003365 Sel1-like repeats; Region: SEL1; smart00671 114615003366 Sel1 repeat; Region: Sel1; cl02723 114615003367 Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5-; Region: TMP_TenI; cd00564 114615003368 thiamine phosphate binding site [chemical binding]; other site 114615003369 active site 114615003370 pyrophosphate binding site [ion binding]; other site 114615003371 fructose-bisphosphate aldolase; Provisional; Region: PRK09197 114615003372 Tagatose-1,6-bisphosphate (TBP) aldolase and related Type B Class II aldolases. TBP aldolase is a tetrameric class II aldolase that catalyzes the reversible condensation of dihydroxyacetone phosphate with glyceraldehyde 3-phsophate to produce tagatose 1; Region: TBP_aldolase_IIB; cd00947 114615003373 intersubunit interface [polypeptide binding]; other site 114615003374 active site 114615003375 zinc binding site [ion binding]; other site 114615003376 Na+ binding site [ion binding]; other site 114615003377 Phosphoglycerate kinase; Region: PGK; pfam00162 114615003378 Phosphoglycerate kinase (PGK) is a monomeric enzyme which catalyzes the transfer of the high-energy phosphate group of 1,3-bisphosphoglycerate to ADP, forming ATP and 3-phosphoglycerate. This reaction represents the first of the two substrate-level...; Region: Phosphoglycerate_kinase; cd00318 114615003379 substrate binding site [chemical binding]; other site 114615003380 hinge regions; other site 114615003381 ADP binding site [chemical binding]; other site 114615003382 catalytic site [active] 114615003383 Glyceraldehyde-3-phosphate dehydrogenase/erythrose-4-phosphate dehydrogenase [Carbohydrate transport and metabolism]; Region: GapA; COG0057 114615003384 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; smart00846 114615003385 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800 114615003386 ATP-dependent DNA helicase RecQ; Region: recQ; TIGR01389 114615003387 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 114615003388 ATP binding site [chemical binding]; other site 114615003389 putative Mg++ binding site [ion binding]; other site 114615003390 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 114615003391 nucleotide binding region [chemical binding]; other site 114615003392 ATP-binding site [chemical binding]; other site 114615003393 This DNA-binding domain is found in the RecQ helicase among others and has a helix-turn-helix structure; Region: RQC; smart00956 114615003394 HRDC domain; Region: HRDC; pfam00570 114615003395 Transketolase [Carbohydrate transport and metabolism]; Region: TktA; COG0021 114615003396 Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012 114615003397 TPP-binding site [chemical binding]; other site 114615003398 dimer interface [polypeptide binding]; other site 114615003399 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 114615003400 PYR/PP interface [polypeptide binding]; other site 114615003401 dimer interface [polypeptide binding]; other site 114615003402 TPP binding site [chemical binding]; other site 114615003403 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 114615003404 Domain of unknown function (DUF4164); Region: DUF4164; pfam13747 114615003405 Cell division protein ZapA; Region: ZapA; pfam05164 114615003406 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109 114615003407 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 114615003408 Beta-lactamase; Region: Beta-lactamase; pfam00144 114615003409 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 114615003410 GST_N family, Saccharomyces cerevisiae GTT1-like subfamily; composed of predominantly uncharacterized proteins with similarity to the S. cerevisiae GST protein, GTT1, and the Schizosaccharomyces pombe GST-III. GSTs are cytosolic dimeric proteins involved...; Region: GST_N_GTT1_like; cd03046 114615003411 putative C-terminal domain interface [polypeptide binding]; other site 114615003412 putative GSH binding site (G-site) [chemical binding]; other site 114615003413 putative dimer interface [polypeptide binding]; other site 114615003414 C-terminal, alpha helical domain of the Glutathione S-transferase family; Region: GST_C_family; cl02776 114615003415 N-terminal domain interface [polypeptide binding]; other site 114615003416 dimer interface [polypeptide binding]; other site 114615003417 substrate binding pocket (H-site) [chemical binding]; other site 114615003418 TRAP transporter solute receptor, TAXI family; Region: TRAP_TAXI; TIGR02122 114615003419 DsrE/DsrF-like family; Region: DrsE; pfam02635 114615003420 5,10-methenyltetrahydrofolate synthetase; Region: MTHFS_bact; TIGR02727 114615003421 Deinococcus radiodurans DR1281 and related proteins, metallophosphatase domain; Region: MPP_DR1281; cd07382 114615003422 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 114615003423 putative active site [active] 114615003424 metal binding site [ion binding]; metal-binding site 114615003425 homodimer binding site [polypeptide binding]; other site 114615003426 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 114615003427 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 114615003428 dimer interface [polypeptide binding]; other site 114615003429 putative CheW interface [polypeptide binding]; other site 114615003430 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 114615003431 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 114615003432 dimer interface [polypeptide binding]; other site 114615003433 putative CheW interface [polypeptide binding]; other site 114615003434 hypothetical protein; Validated; Region: PRK00110 114615003435 Holliday junction resolvases (HJRs) are endonucleases that specifically resolve Holliday junction DNA intermediates during homologous recombination. HJR's occur in archaea, bacteria, and in the mitochondria of certain fungi, however this CD...; Region: RuvC_resolvase; cd00529 114615003436 active site 114615003437 putative DNA-binding cleft [nucleotide binding]; other site 114615003438 dimer interface [polypeptide binding]; other site 114615003439 Holliday junction DNA helicase RuvA; Reviewed; Region: ruvA; PRK00116 114615003440 RuvA N terminal domain; Region: RuvA_N; pfam01330 114615003441 Cytidine deaminase zinc-binding domain. These enzymes are Zn dependent. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a water molecule to form a hydroxide ion that performs a nucleophilic attack on...; Region: cytidine_deaminase; cd01283 114615003442 active site 114615003443 catalytic motif [active] 114615003444 Zn binding site [ion binding]; other site 114615003445 Holliday junction DNA helicase RuvB; Reviewed; Region: ruvB; PRK00080 114615003446 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 114615003447 Walker A motif; other site 114615003448 ATP binding site [chemical binding]; other site 114615003449 Walker B motif; other site 114615003450 arginine finger; other site 114615003451 Holliday junction DNA helicase ruvB C-terminus; Region: RuvB_C; pfam05491 114615003452 Bacillus subtilis YkuE and related proteins, C-terminal metallophosphatase domain; Region: MPP_YkuE_C; cd07385 114615003453 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 114615003454 putative active site [active] 114615003455 putative metal binding site [ion binding]; other site 114615003456 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 114615003457 active site 114615003458 Protein of unknown function (DUF4011); Region: DUF4011; pfam13195 114615003459 Part of AAA domain; Region: AAA_19; pfam13245 114615003460 Superfamily I DNA and RNA helicases and helicase subunits [DNA replication, recombination, and repair]; Region: COG1112 114615003461 AAA domain; Region: AAA_12; pfam13087 114615003462 Superfamily of nucleases including Short Patch Repair (Vsr) Endonucleases, archaeal Holliday junction resolvases, MutH methy-directed DNA mismatch-repair endonucleases, and catalytic domains of many restriction endonucleases, such as EcoRI, BamHI, and...; Region: Restriction_endonuclease_like; cl00277 114615003463 putative active site [active] 114615003464 Protein of unknown function (DUF3320); Region: DUF3320; pfam11784 114615003465 glutathionine S-transferase; Provisional; Region: PRK10542 114615003466 GST_N family, Class Beta subfamily; GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of endogenous and xenobiotic alkylating agents, including carcinogens; Region: GST_N_Beta; cd03057 114615003467 C-terminal domain interface [polypeptide binding]; other site 114615003468 GSH binding site (G-site) [chemical binding]; other site 114615003469 dimer interface [polypeptide binding]; other site 114615003470 C-terminal, alpha helical domain of Class Beta Glutathione S-transferases; Region: GST_C_Beta; cd03188 114615003471 dimer interface [polypeptide binding]; other site 114615003472 N-terminal domain interface [polypeptide binding]; other site 114615003473 substrate binding pocket (H-site) [chemical binding]; other site 114615003474 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 114615003475 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 114615003476 Putative glycerate dehydrogenase and related proteins of the D-specific 2-hydroxy dehydrogenase family; Region: GDH_like_2; cd12164 114615003477 Phosphoglycerate dehydrogenase and related dehydrogenases [Amino acid transport and metabolism]; Region: SerA; COG0111 114615003478 putative ligand binding site [chemical binding]; other site 114615003479 NAD binding site [chemical binding]; other site 114615003480 dimerization interface [polypeptide binding]; other site 114615003481 catalytic site [active] 114615003482 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3795 114615003483 Predicted RNA polymerase sigma factor containing a TPR repeat domain [Transcription]; Region: COG4941 114615003484 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 114615003485 Sigma-70, region 4; Region: Sigma70_r4_2; pfam08281 114615003486 DNA binding residues [nucleotide binding] 114615003487 DoxX-like family; Region: DoxX_2; pfam13564 114615003488 Escherichia coli PhnB and similar proteins; the E. coli phnB gene is found next to an operon involved in the cleavage of carbon-phosphorus bonds in unactivated alkylphosphonates; Region: PhnB_like; cd06588 114615003489 dimer interface [polypeptide binding]; other site 114615003490 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 114615003491 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 114615003492 classical (c) SDRs; Region: SDR_c; cd05233 114615003493 NAD(P) binding site [chemical binding]; other site 114615003494 active site 114615003495 alpha-ketoglutarate decarboxylase; Reviewed; Region: kgd; PRK12270 114615003496 Predicted transcriptional regulators [Transcription]; Region: COG1733 114615003497 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 114615003498 Dihydrofolate reductase [Coenzyme metabolism]; Region: FolA; COG0262 114615003499 RibD C-terminal domain; Region: RibD_C; cl17279 114615003500 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 114615003501 Glutathione S-transferase (GST) family, N-terminal domain; a large, diverse group of cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of endogenous and xenobiotic...; Region: GST_N_family; cd00570 114615003502 C-terminal domain interface [polypeptide binding]; other site 114615003503 GSH binding site (G-site) [chemical binding]; other site 114615003504 dimer interface [polypeptide binding]; other site 114615003505 Glutathione S-transferase, C-terminal domain; Region: GST_C; pfam00043 114615003506 N-terminal domain interface [polypeptide binding]; other site 114615003507 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3795 114615003508 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3795 114615003509 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 114615003510 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 114615003511 WHG domain; Region: WHG; pfam13305 114615003512 Protein of unknown function (DUF2852); Region: DUF2852; pfam11014 114615003513 TolQ protein; Region: tolQ; TIGR02796 114615003514 Biopolymer transport protein [Intracellular trafficking and secretion]; Region: ExbD; COG0848 114615003515 TolR protein; Region: tolR; TIGR02801 114615003516 TolB amino-terminal domain; Region: TolB_N; pfam04052 114615003517 translocation protein TolB; Provisional; Region: tolB; PRK05137 114615003518 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 114615003519 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 114615003520 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 114615003521 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 114615003522 PAS fold; Region: PAS_7; pfam12860 114615003523 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 114615003524 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 114615003525 metal binding site [ion binding]; metal-binding site 114615003526 active site 114615003527 I-site; other site 114615003528 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 114615003529 Autoinducer synthetase; Region: Autoind_synth; cl17404 114615003530 Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885 114615003531 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 114615003532 ligand binding site [chemical binding]; other site 114615003533 tol-pal system protein YbgF; Region: tol_pal_ybgF; TIGR02795 114615003534 N-terminal domain of predicted ATPase of the PP-loop faimly implicated in cell cycle control [Cell division and chromosome partitioning]. This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases...; Region: PP-ATPase; cd01992 114615003535 tRNA(Ile)-lysidine synthase MesJ [Cell cycle control, cell division, chromosome partitioning]; Region: MesJ; COG0037 114615003536 Ligand Binding Site [chemical binding]; other site 114615003537 FtsH Extracellular; Region: FtsH_ext; pfam06480 114615003538 ATP-dependent metalloprotease FtsH; Region: FtsH_fam; TIGR01241 114615003539 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 114615003540 Walker A motif; other site 114615003541 ATP binding site [chemical binding]; other site 114615003542 Walker B motif; other site 114615003543 arginine finger; other site 114615003544 Peptidase family M41; Region: Peptidase_M41; pfam01434 114615003545 Autotransporter beta-domain; Region: Autotransporter; smart00869 114615003546 Protein of unknown function (DUF2029); Region: DUF2029; pfam09594 114615003547 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 114615003548 Protein of unknown function (DUF2029); Region: DUF2029; pfam09594 114615003549 pyruvate kinase; Provisional; Region: PRK06247 114615003550 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl17342 114615003551 domain interfaces; other site 114615003552 active site 114615003553 Protein of unknown function (DUF1036); Region: DUF1036; pfam06282 114615003554 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3492 114615003555 hypothetical protein; Provisional; Region: PRK13694 114615003556 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3108 114615003557 Peptidase M15; Region: Peptidase_M15_3; cl01194 114615003558 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2989 114615003559 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 114615003560 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 114615003561 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204 114615003562 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 114615003563 active site 114615003564 phosphorylation site [posttranslational modification] 114615003565 intermolecular recognition site; other site 114615003566 dimerization interface [polypeptide binding]; other site 114615003567 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 114615003568 Walker A motif; other site 114615003569 ATP binding site [chemical binding]; other site 114615003570 Walker B motif; other site 114615003571 arginine finger; other site 114615003572 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 114615003573 oligoendopeptidase, pepF/M3 family; Region: M3_fam_3; TIGR02290 114615003574 Peptidase family M3B Oligopeptidase F (PepF); Region: M3B_PepF_5; cd09610 114615003575 active site 114615003576 Zn binding site [ion binding]; other site 114615003577 putative addiction module antidote; Region: doc_partner; TIGR02609 114615003578 Fic/DOC family; Region: Fic; cl00960 114615003579 Bacterial aa3 type cytochrome c oxidase subunit IV; Region: COX4_pro_2; pfam07835 114615003580 Rubrum transdehydrogenase NAD-binding and catalytic domains; Region: Rubrum_tdh; cd05304 114615003581 NAD/NADP transhydrogenase alpha subunit [Energy production and conversion]; Region: PntA; COG3288 114615003582 ligand binding site [chemical binding]; other site 114615003583 homodimer interface [polypeptide binding]; other site 114615003584 NAD(P) binding site [chemical binding]; other site 114615003585 trimer interface B [polypeptide binding]; other site 114615003586 trimer interface A [polypeptide binding]; other site 114615003587 Domain of unknown function (DUF3814); Region: DUF3814; pfam12769 114615003588 NAD/NADP transhydrogenase beta subunit [Energy production and conversion]; Region: PntB; COG1282 114615003589 NAD(P) transhydrogenase beta subunit; Region: PNTB; pfam02233 114615003590 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 114615003591 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cd00625 114615003592 Na+/H+ antiporter NhaD and related arsenite permeases [Inorganic ion transport and metabolism]; Region: ArsB; COG1055 114615003593 transmembrane helices; other site 114615003594 Ca2+/H+ antiporter [Inorganic ion transport and metabolism]; Region: ChaA; COG0387 114615003595 Sodium/calcium exchanger protein; Region: Na_Ca_ex; pfam01699 114615003596 30S ribosomal protein S21; Reviewed; Region: rpsU; PRK00270 114615003597 phosphoribosylaminoimidazole carboxylase ATPase subunit; Reviewed; Region: PRK06019 114615003598 ATP-grasp domain; Region: ATP-grasp; pfam02222 114615003599 Phosphoribosylcarboxyaminoimidazole (NCAIR) mutase [Nucleotide transport and metabolism]; Region: PurE; COG0041 114615003600 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 114615003601 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 114615003602 metal binding site [ion binding]; metal-binding site 114615003603 active site 114615003604 I-site; other site 114615003605 Predicted dehydrogenase [General function prediction only]; Region: COG0579 114615003606 hydroxyglutarate oxidase; Provisional; Region: PRK11728 114615003607 PAS domain; Region: PAS; smart00091 114615003608 PAS fold; Region: PAS_7; pfam12860 114615003609 PAS fold; Region: PAS_4; pfam08448 114615003610 PAS fold; Region: PAS_4; pfam08448 114615003611 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 114615003612 putative active site [active] 114615003613 heme pocket [chemical binding]; other site 114615003614 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 114615003615 metal binding site [ion binding]; metal-binding site 114615003616 active site 114615003617 I-site; other site 114615003618 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 114615003619 glycerol-3-phosphate dehydrogenase; Provisional; Region: PRK13369 114615003620 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 114615003621 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 114615003622 ATP-binding cassette domain of the polyamine transporter; Region: ABC_PotA_N; cd03300 114615003623 Walker A/P-loop; other site 114615003624 ATP binding site [chemical binding]; other site 114615003625 Q-loop/lid; other site 114615003626 ABC transporter signature motif; other site 114615003627 Walker B; other site 114615003628 D-loop; other site 114615003629 H-loop/switch region; other site 114615003630 TOBE domain; Region: TOBE_2; pfam08402 114615003631 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 114615003632 dimer interface [polypeptide binding]; other site 114615003633 conserved gate region; other site 114615003634 putative PBP binding loops; other site 114615003635 ABC-ATPase subunit interface; other site 114615003636 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 114615003637 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 114615003638 dimer interface [polypeptide binding]; other site 114615003639 conserved gate region; other site 114615003640 putative PBP binding loops; other site 114615003641 ABC-ATPase subunit interface; other site 114615003642 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 114615003643 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 114615003644 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 114615003645 dimer interface [polypeptide binding]; other site 114615003646 conserved gate region; other site 114615003647 putative PBP binding loops; other site 114615003648 ABC-ATPase subunit interface; other site 114615003649 ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555 114615003650 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 114615003651 dimer interface [polypeptide binding]; other site 114615003652 conserved gate region; other site 114615003653 putative PBP binding loops; other site 114615003654 ABC-ATPase subunit interface; other site 114615003655 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 114615003656 Uncharacterized protein involved in outer membrane biogenesis [Cell envelope biogenesis, outer membrane]; Region: AsmA; COG2982 114615003657 AsmA-like C-terminal region; Region: AsmA_2; pfam13502 114615003658 Acyl CoA:acetate/3-ketoacid CoA transferase, alpha subunit [Lipid metabolism]; Region: AtoD; COG1788 114615003659 3-oxoacid CoA-transferase, B subunit; Region: pcaJ_scoB_fam; TIGR02428 114615003660 Phosphorylase superfamily; Region: PNP_UDP_1; cl00303 114615003661 Uncharacterized conserved protein [Function unknown]; Region: COG1262 114615003662 Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; pfam03781 114615003663 nitrite reductase, copper-containing; Region: Cu_nitrite_red; TIGR02376 114615003664 Multicopper oxidase; Region: Cu-oxidase_3; pfam07732 114615003665 Multicopper oxidase; Region: Cu-oxidase; pfam00394 114615003666 coproporphyrinogen III oxidase; Provisional; Region: PRK09249 114615003667 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 114615003668 FeS/SAM binding site; other site 114615003669 HemN C-terminal domain; Region: HemN_C; pfam06969 114615003670 hybrid cluster protein-associated redox disulfide domain; Region: prismane_assoc; TIGR03980 114615003671 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 114615003672 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 114615003673 ligand binding site [chemical binding]; other site 114615003674 flexible hinge region; other site 114615003675 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 114615003676 putative switch regulator; other site 114615003677 non-specific DNA interactions [nucleotide binding]; other site 114615003678 DNA binding site [nucleotide binding] 114615003679 sequence specific DNA binding site [nucleotide binding]; other site 114615003680 putative cAMP binding site [chemical binding]; other site 114615003681 NnrS protein; Region: NnrS; pfam05940 114615003682 PAS domain; Region: PAS_9; pfam13426 114615003683 PAS domain; Region: PAS_8; pfam13188 114615003684 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 114615003685 putative active site [active] 114615003686 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 114615003687 heme pocket [chemical binding]; other site 114615003688 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 114615003689 dimer interface [polypeptide binding]; other site 114615003690 phosphorylation site [posttranslational modification] 114615003691 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 114615003692 ATP binding site [chemical binding]; other site 114615003693 Mg2+ binding site [ion binding]; other site 114615003694 G-X-G motif; other site 114615003695 Phasin protein; Region: Phasin_2; cl11491 114615003696 phasin; Region: phasin_2; TIGR01985 114615003697 conjugal transfer relaxase TraA; Provisional; Region: PRK13889 114615003698 MobA/MobL family; Region: MobA_MobL; pfam03389 114615003699 AAA domain; Region: AAA_30; pfam13604 114615003700 Family description; Region: UvrD_C_2; pfam13538 114615003701 Conjugal transfer protein TraD; Region: TraD; pfam06412 114615003702 Caspase domain; Region: Peptidase_C14; pfam00656 114615003703 Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cl10459 114615003704 Subtilisin-like serine proteases [Posttranslational modification, protein turnover, chaperones]; Region: AprE; COG1404 114615003705 active site 114615003706 catalytic residues [active] 114615003707 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 114615003708 AAA domain; Region: AAA_21; pfam13304 114615003709 Walker A/P-loop; other site 114615003710 ATP binding site [chemical binding]; other site 114615003711 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 114615003712 Q-loop/lid; other site 114615003713 ABC transporter signature motif; other site 114615003714 Walker B; other site 114615003715 D-loop; other site 114615003716 H-loop/switch region; other site 114615003717 Family description; Region: UvrD_C_2; pfam13538 114615003718 Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cl10459 114615003719 active site 114615003720 catalytic residues [active] 114615003721 PAP2_like proteins, a super-family of histidine phosphatases and vanadium haloperoxidases, includes type 2 phosphatidic acid phosphatase or lipid phosphate phosphatase (LPP), Glucose-6-phosphatase, Phosphatidylglycerophosphatase B and bacterial acid...; Region: PAP2_like; cl00474 114615003722 active site 114615003723 Predicted integral membrane protein [Function unknown]; Region: COG5616 114615003724 TPR repeat; Region: TPR_11; pfam13414 114615003725 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 114615003726 TPR motif; other site 114615003727 binding surface 114615003728 Zinc-dependent metalloprotease. This super-family of metalloproteases contains two major branches, the astacin-like proteases and the adamalysin/reprolysin-like proteases. Both branches have wide phylogenetic distribution, and contain sub-families, which...; Region: ZnMc; cl00064 114615003729 active site 114615003730 Dyp-type peroxidase family; Region: Dyp_perox; cl01067 114615003731 PAP2, haloperoxidase_like subfamily. Haloperoxidases catalyze the oxidation of halides such as bromide or chloride by hydrogen peroxide, which results in subsequent halogenation of organic substrates, or halide-assisted disproportionation of hydrogen...; Region: PAP2_haloperoxidase; cd03398 114615003732 active site 114615003733 Bacteriophage P4 integrase. P4-like integrases are found in temperate bacteriophages, integrative plasmids, pathogenicity and symbiosis islands, and other mobile genetic elements. They share the same fold in their catalytic domain and the overall...; Region: INT_P4; cd00801 114615003734 Integrase [DNA replication, recombination, and repair]; Region: XerC; COG0582 114615003735 active site 114615003736 Int/Topo IB signature motif; other site 114615003737 FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202 114615003738 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 114615003739 putative active site [active] 114615003740 heme pocket [chemical binding]; other site 114615003741 FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202 114615003742 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 114615003743 putative active site [active] 114615003744 heme pocket [chemical binding]; other site 114615003745 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 114615003746 putative active site [active] 114615003747 heme pocket [chemical binding]; other site 114615003748 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 114615003749 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 114615003750 dimer interface [polypeptide binding]; other site 114615003751 putative CheW interface [polypeptide binding]; other site 114615003752 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 114615003753 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 114615003754 DNA binding residues [nucleotide binding] 114615003755 dimerization interface [polypeptide binding]; other site 114615003756 PAS fold; Region: PAS_2; pfam08446 114615003757 GAF domain; Region: GAF; cl17456 114615003758 Phytochrome region; Region: PHY; pfam00360 114615003759 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 114615003760 anti sigma factor interaction site; other site 114615003761 regulatory phosphorylation site [posttranslational modification]; other site 114615003762 Heme oxygenase catalyzes the rate limiting step in the degradation of heme to bilirubin, it is essential for recycling of iron from heme. Heme is used as a substrate and cofactor for its own degradation to biliverdin, iron, and carbon monoxide. This...; Region: HemeO; cl17299 114615003763 heme ligand [chemical binding]; other site 114615003764 heme binding pocket [chemical binding]; other site 114615003765 Ferredoxin-dependent bilin reductase; Region: Fe_bilin_red; cl07930 114615003766 pyridoxal phosphate-dependent acyltransferase, putative; Region: gly_Cac_T_rel; TIGR01825 114615003767 KBL_like; this family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to serine palmitoyltransferase (SPT), 5-aminolevulinate synthase (ALAS); Region: KBL_like; cd06454 114615003768 substrate-cofactor binding pocket; other site 114615003769 pyridoxal 5'-phosphate binding site [chemical binding]; other site 114615003770 catalytic residue [active] 114615003771 gas vesicle protein GvpN; Region: gas_vesic_GvpN; TIGR02640 114615003772 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 114615003773 Walker A motif; other site 114615003774 ATP binding site [chemical binding]; other site 114615003775 Walker B motif; other site 114615003776 arginine finger; other site 114615003777 Gas vesicle synthesis protein GvpO; Region: GvpO; pfam05800 114615003778 Gas vesicle protein; Region: Gas_vesicle; pfam00741 114615003779 Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071 114615003780 This domain family includes the alpha-crystallin domain (ACD) of alpha-crystallin-type small heat shock proteins (sHsps) and a similar domain found in p23-like proteins. sHsps are small stress induced proteins with monomeric masses between 12 -43 kDa; Region: ACD_sHsps_p23-like; cd00298 114615003781 Gas vesicle synthesis protein GvpL/GvpF; Region: GvpL_GvpF; pfam06386 114615003782 Gas vesicle protein G; Region: GvpG; pfam05120 114615003783 Cell division protein 48 (CDC48), N-terminal domain; Region: CDC48_N; pfam02359 114615003784 AAA family ATPase, CDC48 subfamily; Region: CDC48; TIGR01243 114615003785 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 114615003786 Walker A motif; other site 114615003787 ATP binding site [chemical binding]; other site 114615003788 Walker B motif; other site 114615003789 arginine finger; other site 114615003790 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 114615003791 Walker A motif; other site 114615003792 ATP binding site [chemical binding]; other site 114615003793 Walker B motif; other site 114615003794 arginine finger; other site 114615003795 Gas vesicle synthesis protein GvpL/GvpF; Region: GvpL_GvpF; pfam06386 114615003796 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 114615003797 HSP70 interaction site [polypeptide binding]; other site 114615003798 Gas vesicle synthesis protein GvpL/GvpF; Region: GvpL_GvpF; pfam06386 114615003799 Gas vesicle protein; Region: Gas_vesicle; pfam00741 114615003800 Gas vesicle protein K; Region: GvpK; pfam05121 114615003801 chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168 114615003802 gas vesicle synthesis protein GvpA; Provisional; Region: PRK09371 114615003803 Y-family of DNA polymerases; Region: PolY; cl12025 114615003804 Domain of unknown function (DUF4399); Region: DUF4399; pfam14347 114615003805 Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; pfam03781 114615003806 Uncharacterized conserved protein [Function unknown]; Region: COG1262 114615003807 type II secretion system protein D; Region: type_II_gspD; TIGR02517 114615003808 Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958 114615003809 Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958 114615003810 Bacterial type II and III secretion system protein; Region: Secretin; pfam00263 114615003811 FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790 114615003812 Sel1-like repeats; Region: SEL1; smart00671 114615003813 Type II secretion system (T2SS), protein E, N-terminal domain; Region: T2SE_Nter; pfam05157 114615003814 type II secretion system protein E; Region: type_II_gspE; TIGR02533 114615003815 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 114615003816 Walker A motif; other site 114615003817 ATP binding site [chemical binding]; other site 114615003818 Walker B motif; other site 114615003819 Type II secretory pathway, component PulF [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulF; COG1459 114615003820 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 114615003821 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 114615003822 type II secretion system protein G; Region: typeII_sec_gspG; TIGR01710 114615003823 Type II secretion system (T2SS), protein G; Region: T2SG; pfam08334 114615003824 Helix-hairpin-helix motif; Region: HHH_3; pfam12836 114615003825 Fimbrial assembly protein (PilN); Region: PilN; pfam05137 114615003826 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 114615003827 Type II secretion system (T2SS), protein M subtype b; Region: T2SM_b; pfam10741 114615003828 Multicopper oxidase; Region: Cu-oxidase_3; pfam07732 114615003829 Multicopper oxidase; Region: Cu-oxidase_2; pfam07731 114615003830 FMN-binding domain; Region: FMN_bind; pfam04205 114615003831 Membrane-associated lipoprotein involved in thiamine biosynthesis [Coenzyme metabolism]; Region: ApbE; COG1477 114615003832 ApbE family; Region: ApbE; pfam02424 114615003833 Methyltransferase domain; Region: Methyltransf_23; pfam13489 114615003834 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 114615003835 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 114615003836 S-adenosylmethionine binding site [chemical binding]; other site 114615003837 Toxic anion resistance protein (TelA); Region: TelA; pfam05816 114615003838 Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531 114615003839 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198 114615003840 metal ion-dependent adhesion site (MIDAS); other site 114615003841 5-bromo-4-chloroindolyl phosphate hydrolysis protein; Region: Halogen_Hydrol; pfam10112 114615003842 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 114615003843 P-loop; other site 114615003844 Magnesium ion binding site [ion binding]; other site 114615003845 Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329 114615003846 Dihydrodipicolinate synthase (DHDPS); Region: DHDPS; cd00950 114615003847 dimer interface [polypeptide binding]; other site 114615003848 active site 114615003849 catalytic residue [active] 114615003850 Transcriptional regulator [Transcription]; Region: LysR; COG0583 114615003851 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 114615003852 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 114615003853 putative effector binding pocket; other site 114615003854 dimerization interface [polypeptide binding]; other site 114615003855 thioredoxin-disulfide reductase; Region: TRX_reduct; TIGR01292 114615003856 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 114615003857 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 114615003858 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 114615003859 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 114615003860 putative DNA binding site [nucleotide binding]; other site 114615003861 putative Zn2+ binding site [ion binding]; other site 114615003862 AsnC family; Region: AsnC_trans_reg; pfam01037 114615003863 Predicted membrane protein [Function unknown]; Region: COG2259 114615003864 transcription elongation factor GreA; Reviewed; Region: greA; PRK00226 114615003865 Transcription elongation factor, N-terminal; Region: GreA_GreB_N; pfam03449 114615003866 Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272 114615003867 carbamoyl phosphate synthase large subunit; Reviewed; Region: carB; PRK05294 114615003868 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 114615003869 ATP-grasp domain; Region: ATP-grasp_4; cl17255 114615003870 Carbamoyl-phosphate synthetase large chain, oligomerisation domain; Region: CPSase_L_D3; pfam02787 114615003871 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 114615003872 ATP-grasp domain; Region: ATP-grasp_4; cl17255 114615003873 Methylglyoxal synthase-like domain from type II glutamine-dependent carbamoyl phosphate synthetase (CSP). CSP, a CarA and CarB heterodimer, catalyzes the production of carbamoyl phosphate which is subsequently employed in the metabolic pathways...; Region: MGS_CPS_II; cd01424 114615003874 IMP binding site; other site 114615003875 dimer interface [polypeptide binding]; other site 114615003876 interdomain contacts; other site 114615003877 partial ornithine binding site; other site 114615003878 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 114615003879 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 114615003880 putative substrate translocation pore; other site 114615003881 helix_turn_helix, Arsenical Resistance Operon Repressor; Region: HTH_ARSR; smart00418 114615003882 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 114615003883 S-adenosylmethionine binding site [chemical binding]; other site 114615003884 DPS protein, ferritin-like diiron-binding domain; Region: DPS; cd01043 114615003885 Ferritin-like domain; Region: Ferritin; pfam00210 114615003886 dimerization interface [polypeptide binding]; other site 114615003887 DPS ferroxidase diiron center [ion binding]; other site 114615003888 ion pore; other site 114615003889 Predicted transporter component [General function prediction only]; Region: COG2391 114615003890 Sulphur transport; Region: Sulf_transp; pfam04143 114615003891 Predicted transporter component [General function prediction only]; Region: COG2391 114615003892 Domain of unknown function (DUF4341); Region: DUF4341; pfam14241 114615003893 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 114615003894 dimerization interface [polypeptide binding]; other site 114615003895 putative DNA binding site [nucleotide binding]; other site 114615003896 putative Zn2+ binding site [ion binding]; other site 114615003897 Uncharacterized protein containing double-stranded beta helix domain [Function unknown]; Region: COG4297 114615003898 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 114615003899 putative DNA binding site [nucleotide binding]; other site 114615003900 putative Zn2+ binding site [ion binding]; other site 114615003901 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_16; cd08502 114615003902 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 114615003903 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 114615003904 CoenzymeA binding site [chemical binding]; other site 114615003905 subunit interaction site [polypeptide binding]; other site 114615003906 PHB binding site; other site 114615003907 carbamoyl phosphate synthase small subunit; Reviewed; Region: PRK12564 114615003908 Carbamoyl-phosphate synthase small chain, CPSase domain; Region: CPSase_sm_chain; smart01097 114615003909 Small chain of the glutamine-dependent form of carbamoyl phosphate synthase, CPSase II; Region: GATase1_CPSase; cd01744 114615003910 catalytic site [active] 114615003911 subunit interface [polypeptide binding]; other site 114615003912 Yqey-like protein; Region: YqeY; pfam09424 114615003913 Acyl-coenzyme A synthetases/AMP-(fatty) acid ligases [Lipid metabolism]; Region: Acs; COG0365 114615003914 Uncharacterized subfamily of medium-chain acyl-CoA synthetase (MACS); Region: MACS_like_3; cd05971 114615003915 active site 114615003916 acyl-activating enzyme (AAE) consensus motif; other site 114615003917 putative CoA binding site [chemical binding]; other site 114615003918 AMP binding site [chemical binding]; other site 114615003919 Predicted integral membrane protein (DUF2189); Region: DUF2189; cl02291 114615003920 Putative hydrophobic ligand-binding SRPBCC domain of an uncharacterized subgroup of CalC- and Aha1-like proteins; some contain an N-terminal GntR family winged HTH DNA-binding domain; Region: SRPBCC_CalC_Aha1-like_GntR-HTH; cd08893 114615003921 putative hydrophobic ligand binding site [chemical binding]; other site 114615003922 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 114615003923 dimerization interface [polypeptide binding]; other site 114615003924 putative DNA binding site [nucleotide binding]; other site 114615003925 putative Zn2+ binding site [ion binding]; other site 114615003926 Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280 114615003927 Predicted epimerase, PhzC/PhzF homolog [General function prediction only]; Region: COG0384 114615003928 Domain of unknown function (DUF1127); Region: DUF1127; cl02276 114615003929 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 114615003930 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 114615003931 DNA-binding site [nucleotide binding]; DNA binding site 114615003932 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 114615003933 pyridoxal 5'-phosphate binding site [chemical binding]; other site 114615003934 homodimer interface [polypeptide binding]; other site 114615003935 catalytic residue [active] 114615003936 N-formylglutamate amidohydrolase; Region: FGase; cl01522 114615003937 Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305 114615003938 Transglutaminase-like superfamily; Region: Transglut_core; pfam01841 114615003939 GGCT-like domains, also called AIG2-like family. Gamma-glutamyl cyclotransferase (GGCT) catalyzes the formation of pyroglutamic acid (5-oxoproline) from dipeptides containing gamma-glutamyl, and is a dimeric protein. In Homo sapiens, the protein is...; Region: GGCT_like; cd06661 114615003940 putative active site pocket [active] 114615003941 dimerization interface [polypeptide binding]; other site 114615003942 putative catalytic residue [active] 114615003943 DNA primase; Validated; Region: dnaG; PRK05667 114615003944 CHC2 zinc finger; Region: zf-CHC2; cl17510 114615003945 DNA primase catalytic core, N-terminal domain; Region: Toprim_N; pfam08275 114615003946 TOPRIM_DnaG_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of proteins similar to Escherichia coli DnaG. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_DnaG_primases; cd03364 114615003947 active site 114615003948 metal binding site [ion binding]; metal-binding site 114615003949 interdomain interaction site; other site 114615003950 DnaB-helicase binding domain of primase; Region: DnaB_bind; pfam10410 114615003951 RNA polymerase sigma factor RpoD; Validated; Region: PRK05658 114615003952 Sigma-70 factor, region 1.1; Region: Sigma70_r1_1; pfam03979 114615003953 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 114615003954 Sigma-70, non-essential region; Region: Sigma70_ner; pfam04546 114615003955 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 114615003956 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 114615003957 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 114615003958 DNA binding residues [nucleotide binding] 114615003959 Protein of unknown function (DUF817); Region: DUF817; pfam05675 114615003960 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 114615003961 binding surface 114615003962 TPR motif; other site 114615003963 FOG: TPR repeat [General function prediction only]; Region: NrfG; COG0457 114615003964 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 114615003965 binding surface 114615003966 TPR motif; other site 114615003967 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 114615003968 binding surface 114615003969 TPR motif; other site 114615003970 Predicted O-linked N-acetylglucosamine transferase, SPINDLY family [Posttranslational modification, protein turnover, chaperones]; Region: Spy; COG3914 114615003971 Protein of unknown function, DUF393; Region: DUF393; cl01136 114615003972 lytic murein transglycosylase; Region: MltB_2; TIGR02283 114615003973 murein hydrolase B; Provisional; Region: PRK10760; cl17906 114615003974 short chain dehydrogenase; Provisional; Region: PRK06181 114615003975 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 114615003976 NAD(P) binding site [chemical binding]; other site 114615003977 active site 114615003978 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 114615003979 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 114615003980 active site 114615003981 phosphorylation site [posttranslational modification] 114615003982 intermolecular recognition site; other site 114615003983 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 114615003984 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 114615003985 metal binding site [ion binding]; metal-binding site 114615003986 active site 114615003987 I-site; other site 114615003988 Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583 114615003989 amidase catalytic site [active] 114615003990 Zn binding residues [ion binding]; other site 114615003991 substrate binding site [chemical binding]; other site 114615003992 RNA polymerase factor sigma-32; Reviewed; Region: PRK06596 114615003993 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 114615003994 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 114615003995 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 114615003996 DNA binding residues [nucleotide binding] 114615003997 pseudouridine synthase, RluA family; Region: rluA_subfam; TIGR00005 114615003998 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 114615003999 RNA binding surface [nucleotide binding]; other site 114615004000 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 114615004001 active site 114615004002 Adenine specific DNA methylase Mod [DNA replication, recombination, and repair]; Region: COG2189 114615004003 DNA methylase; Region: N6_N4_Mtase; cl17433 114615004004 DNA methylase; Region: N6_N4_Mtase; cl17433 114615004005 DEAD-like helicases superfamily; Region: DEXDc; smart00487 114615004006 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 114615004007 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 114615004008 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 114615004009 Cytochrome P450; Region: p450; cl12078 114615004010 ParB-like nuclease domain; Region: ParB; smart00470 114615004011 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 114615004012 active site 114615004013 Catalase-like heme-binding proteins similar to the uncharacterized srpA; Region: srpA_like; cd08153 114615004014 putative heme binding pocket [chemical binding]; other site 114615004015 Opacity protein and related surface antigens [Cell envelope biogenesis, outer membrane]; Region: COG3637 114615004016 Protein of unknown function (DUF3160); Region: DUF3160; pfam11369 114615004017 Bacterial capsule synthesis protein PGA_cap; Region: PGA_cap; smart00854 114615004018 CapA and related proteins, metallophosphatase domain; Region: MPP_CapA; cd07381 114615004019 putative active site [active] 114615004020 putative metal binding site [ion binding]; other site 114615004021 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 114615004022 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 114615004023 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 114615004024 Dehydroquinase (DHQase), type II. Dehydroquinase (or 3-dehydroquinate dehydratase) catalyzes the reversible dehydration of 3-dehydroquinate to form 3-dehydroshikimate. This reaction is part of two metabolic pathways: the biosynthetic shikimate pathway...; Region: DHQase_II; cd00466 114615004025 Dehydroquinase class II; Region: DHquinase_II; pfam01220 114615004026 trimer interface [polypeptide binding]; other site 114615004027 active site 114615004028 dimer interface [polypeptide binding]; other site 114615004029 Transcriptional activator of acetoin/glycerol metabolism [Secondary metabolites biosynthesis, transport, and catabolism / Transcription]; Region: AcoR; COG3284 114615004030 GAF domain; Region: GAF; pfam01590 114615004031 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 114615004032 Ralstonia eutrophus NAD+-dependent acetaldehyde dehydrogenase II-like; Region: ALDH_ACDHII-AcoD; cd07116 114615004033 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 114615004034 NAD(P) binding site [chemical binding]; other site 114615004035 catalytic residues [active] 114615004036 Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cl00938 114615004037 iron-sulfur cluster [ion binding]; other site 114615004038 [2Fe-2S] cluster binding site [ion binding]; other site 114615004039 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cl02542 114615004040 HSP70 interaction site [polypeptide binding]; other site 114615004041 PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705 114615004042 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 114615004043 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: RbsB; COG1879 114615004044 Periplasmic sugar-binding domain of uncharacterized ABC-type transport systems; Region: PBP1_ABC_sugar_binding_like_11; cd06321 114615004045 putative ligand binding site [chemical binding]; other site 114615004046 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 114615004047 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 114615004048 TM-ABC transporter signature motif; other site 114615004049 ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129 114615004050 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 114615004051 Walker A/P-loop; other site 114615004052 ATP binding site [chemical binding]; other site 114615004053 Q-loop/lid; other site 114615004054 ABC transporter signature motif; other site 114615004055 Walker B; other site 114615004056 D-loop; other site 114615004057 H-loop/switch region; other site 114615004058 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 114615004059 Sugar (pentulose and hexulose) kinases [Carbohydrate transport and metabolism]; Region: XylB; COG1070 114615004060 Escherichia coli xylulokinase-like D-xylulose kinases; a subgroup of the FGGY family of carbohydrate kinases; Region: FGGY_D-XK_EcXK-like; cd07808 114615004061 N- and C-terminal domain interface [polypeptide binding]; other site 114615004062 active site 114615004063 MgATP binding site [chemical binding]; other site 114615004064 catalytic site [active] 114615004065 metal binding site [ion binding]; metal-binding site 114615004066 xylulose binding site [chemical binding]; other site 114615004067 homodimer interface [polypeptide binding]; other site 114615004068 glucose-1-dehydrogenase; Provisional; Region: PRK08936 114615004069 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 114615004070 NAD(P) binding site [chemical binding]; other site 114615004071 active site 114615004072 Protein of unknown function (DUF1446); Region: DUF1446; pfam07287 114615004073 Choline dehydrogenase and related flavoproteins [Amino acid transport and metabolism]; Region: BetA; COG2303 114615004074 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 114615004075 Gamma-glutamyltransferase [Amino acid transport and metabolism]; Region: Ggt; COG0405 114615004076 Gamma-glutamyltranspeptidase; Region: G_glu_transpept; pfam01019 114615004077 D-glutamate deacylase; Validated; Region: PRK09061 114615004078 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 114615004079 active site 114615004080 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 114615004081 Putative GTPases (G3E family) [General function prediction only]; Region: COG0523 114615004082 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 114615004083 Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; smart00833 114615004084 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 114615004085 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 114615004086 metal binding site [ion binding]; metal-binding site 114615004087 active site 114615004088 I-site; other site 114615004089 DnaJ-class molecular chaperone with C-terminal Zn finger domain [Posttranslational modification, protein turnover, chaperones]; Region: DnaJ; COG0484 114615004090 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 114615004091 HSP70 interaction site [polypeptide binding]; other site 114615004092 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 114615004093 TPR repeat; Region: TPR_11; pfam13414 114615004094 binding surface 114615004095 TPR motif; other site 114615004096 Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329 114615004097 Dihydrodipicolinate synthase family; Region: DHDPS-like; cd00408 114615004098 inhibitor site; inhibition site 114615004099 active site 114615004100 dimer interface [polypeptide binding]; other site 114615004101 catalytic residue [active] 114615004102 Aerobic-type carbon monoxide dehydrogenase, large subunit CoxL/CutL homologs [Energy production and conversion]; Region: CoxL; COG1529 114615004103 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; smart01008 114615004104 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 114615004105 Two-component sensor kinase N-terminal; Region: 2CSK_N; pfam08521 114615004106 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 114615004107 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 114615004108 dimer interface [polypeptide binding]; other site 114615004109 phosphorylation site [posttranslational modification] 114615004110 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 114615004111 ATP binding site [chemical binding]; other site 114615004112 G-X-G motif; other site 114615004113 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 114615004114 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 114615004115 active site 114615004116 phosphorylation site [posttranslational modification] 114615004117 intermolecular recognition site; other site 114615004118 dimerization interface [polypeptide binding]; other site 114615004119 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 114615004120 DNA binding site [nucleotide binding] 114615004121 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 114615004122 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 114615004123 Walker A/P-loop; other site 114615004124 ATP binding site [chemical binding]; other site 114615004125 Q-loop/lid; other site 114615004126 ABC transporter signature motif; other site 114615004127 Walker B; other site 114615004128 D-loop; other site 114615004129 H-loop/switch region; other site 114615004130 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 114615004131 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 114615004132 NMT1-like family; Region: NMT1_2; pfam13379 114615004133 ABC transporter, substrate-binding protein, aliphatic sulfonates family; Region: SsuA_fam; TIGR01728 114615004134 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054 114615004135 dimerization interface [polypeptide binding]; other site 114615004136 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 114615004137 ATP binding site [chemical binding]; other site 114615004138 Mg2+ binding site [ion binding]; other site 114615004139 G-X-G motif; other site 114615004140 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 114615004141 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 114615004142 active site 114615004143 phosphorylation site [posttranslational modification] 114615004144 intermolecular recognition site; other site 114615004145 dimerization interface [polypeptide binding]; other site 114615004146 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 114615004147 DNA binding site [nucleotide binding] 114615004148 Uncharacterized conserved protein [Function unknown]; Region: LemA; COG1704 114615004149 Beta-propeller domains of methanol dehydrogenase type [General function prediction only]; Region: COG1512 114615004150 Repair protein; Region: Repair_PSII; pfam04536 114615004151 Repair protein; Region: Repair_PSII; pfam04536 114615004152 Predicted transcriptional regulator [Transcription]; Region: COG2378 114615004153 HTH domain; Region: HTH_11; pfam08279 114615004154 WYL domain; Region: WYL; pfam13280 114615004155 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 114615004156 GST_N family, Saccharomyces cerevisiae GTT1-like subfamily; composed of predominantly uncharacterized proteins with similarity to the S. cerevisiae GST protein, GTT1, and the Schizosaccharomyces pombe GST-III. GSTs are cytosolic dimeric proteins involved...; Region: GST_N_GTT1_like; cd03046 114615004157 putative C-terminal domain interface [polypeptide binding]; other site 114615004158 putative GSH binding site (G-site) [chemical binding]; other site 114615004159 putative dimer interface [polypeptide binding]; other site 114615004160 C-terminal, alpha helical domain of an unknown subfamily 8 of Glutathione S-transferases; Region: GST_C_8; cd03207 114615004161 dimer interface [polypeptide binding]; other site 114615004162 N-terminal domain interface [polypeptide binding]; other site 114615004163 putative substrate binding pocket (H-site) [chemical binding]; other site 114615004164 Predicted acyl esterases [General function prediction only]; Region: COG2936 114615004165 X-Pro dipeptidyl-peptidase C-terminal non-catalytic domain; Region: PepX_C; smart00939 114615004166 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 114615004167 AsnC-type helix-turn-helix domain; Region: HTH_AsnC-type; pfam13404 114615004168 putative DNA binding site [nucleotide binding]; other site 114615004169 putative Zn2+ binding site [ion binding]; other site 114615004170 AsnC family; Region: AsnC_trans_reg; pfam01037 114615004171 Cupin domain; Region: Cupin_2; cl17218 114615004172 Protein of unknown function (DUF1493); Region: DUF1493; pfam07377 114615004173 TATA element modulatory factor 1 TATA binding; Region: TMF_TATA_bd; pfam12325 114615004174 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 114615004175 CoA-transferase family III; Region: CoA_transf_3; pfam02515 114615004176 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 114615004177 DNA-binding site [nucleotide binding]; DNA binding site 114615004178 RNA-binding motif; other site 114615004179 Ferredoxin [Energy production and conversion]; Region: Fdx; COG0633 114615004180 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 114615004181 catalytic loop [active] 114615004182 iron binding site [ion binding]; other site 114615004183 Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114 114615004184 cyclase homology domain; Region: CHD; cd07302 114615004185 nucleotidyl binding site; other site 114615004186 metal binding site [ion binding]; metal-binding site 114615004187 dimer interface [polypeptide binding]; other site 114615004188 4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family [Cell envelope biogenesis, outer membrane]; Region: ArnT; COG1807 114615004189 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; pfam13231 114615004190 hypothetical protein; Provisional; Region: PRK05415 114615004191 Domain of unknown function (DUF697); Region: DUF697; cl12064 114615004192 YcjX-like family, DUF463; Region: DUF463; pfam04317 114615004193 Predicted membrane protein, hemolysin III homolog [General function prediction only]; Region: COG1272 114615004194 channel protein, hemolysin III family; Region: hlyIII; TIGR01065 114615004195 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK05565 114615004196 classical (c) SDRs; Region: SDR_c; cd05233 114615004197 NAD(P) binding site [chemical binding]; other site 114615004198 active site 114615004199 Uncharacterized protein conserved in bacteria (DUF2320); Region: DUF2320; pfam10082 114615004200 benzoylformate decarboxylase; Reviewed; Region: PRK07092 114615004201 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 114615004202 PYR/PP interface [polypeptide binding]; other site 114615004203 dimer interface [polypeptide binding]; other site 114615004204 TPP binding site [chemical binding]; other site 114615004205 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 114615004206 Thiamine pyrophosphate (TPP) family, BFDC subfamily, TPP-binding module; composed of proteins similar to Pseudomonas putida benzoylformate decarboxylase (BFDC). P. putida BFDC plays a role in the mandelate pathway, catalyzing the conversion of...; Region: TPP_BFDC; cd02002 114615004207 TPP-binding site [chemical binding]; other site 114615004208 dimer interface [polypeptide binding]; other site 114615004209 Uncharacterized conserved protein [Function unknown]; Region: COG3777 114615004210 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 114615004211 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 114615004212 active site 2 [active] 114615004213 active site 1 [active] 114615004214 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 114615004215 CoA-transferase family III; Region: CoA_transf_3; pfam02515 114615004216 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 114615004217 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 114615004218 active site 114615004219 hypothetical protein; Provisional; Region: PRK06163 114615004220 Thiamine pyrophosphate (TPP) family, ComE subfamily, TPP-binding module; composed of proteins similar to Methanococcus jannaschii sulfopyruvate decarboxylase beta subunit (ComE). M. jannaschii sulfopyruvate decarboxylase (ComDE) is a dodecamer of six...; Region: TPP_ComE; cd03372 114615004221 TPP-binding site; other site 114615004222 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 114615004223 PYR/PP interface [polypeptide binding]; other site 114615004224 dimer interface [polypeptide binding]; other site 114615004225 TPP binding site [chemical binding]; other site 114615004226 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 114615004227 Cytochrome P450; Region: p450; cl12078 114615004228 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 114615004229 Cytochrome P450; Region: p450; cl12078 114615004230 Isovaleryl-CoA dehydrogenase; Region: IVD; cd01156 114615004231 isovaleryl-CoA dehydrogenase; Region: PLN02519 114615004232 substrate binding site [chemical binding]; other site 114615004233 FAD binding site [chemical binding]; other site 114615004234 catalytic base [active] 114615004235 Bacterial protein of unknown function (DUF898); Region: DUF898; pfam05987 114615004236 Zn-dependent protease with chaperone function [Posttranslational modification, protein turnover, chaperones]; Region: HtpX; COG0501 114615004237 Protein of unknown function (DUF2927); Region: DUF2927; pfam11150 114615004238 Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376 114615004239 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 114615004240 hypothetical protein; Validated; Region: PRK07586 114615004241 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 114615004242 PYR/PP interface [polypeptide binding]; other site 114615004243 dimer interface [polypeptide binding]; other site 114615004244 TPP binding site [chemical binding]; other site 114615004245 Thiamine pyrophosphate (TPP) family, BFDC subfamily, TPP-binding module; composed of proteins similar to Pseudomonas putida benzoylformate decarboxylase (BFDC). P. putida BFDC plays a role in the mandelate pathway, catalyzing the conversion of...; Region: TPP_BFDC; cd02002 114615004246 TPP-binding site [chemical binding]; other site 114615004247 dimer interface [polypeptide binding]; other site 114615004248 Cytochrome c; Region: Cytochrom_C; cl11414 114615004249 Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010 114615004250 Uncharacterized conserved protein [Function unknown]; Region: COG3287 114615004251 FIST N domain; Region: FIST; pfam08495 114615004252 FIST C domain; Region: FIST_C; pfam10442 114615004253 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 114615004254 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 114615004255 ATP binding site [chemical binding]; other site 114615004256 Mg2+ binding site [ion binding]; other site 114615004257 G-X-G motif; other site 114615004258 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 114615004259 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 114615004260 active site 114615004261 phosphorylation site [posttranslational modification] 114615004262 intermolecular recognition site; other site 114615004263 dimerization interface [polypeptide binding]; other site 114615004264 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 114615004265 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 114615004266 active site 114615004267 phosphorylation site [posttranslational modification] 114615004268 intermolecular recognition site; other site 114615004269 dimerization interface [polypeptide binding]; other site 114615004270 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 114615004271 DNA binding residues [nucleotide binding] 114615004272 dimerization interface [polypeptide binding]; other site 114615004273 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 114615004274 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 114615004275 active site 114615004276 phosphorylation site [posttranslational modification] 114615004277 intermolecular recognition site; other site 114615004278 dimerization interface [polypeptide binding]; other site 114615004279 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 114615004280 DNA binding residues [nucleotide binding] 114615004281 dimerization interface [polypeptide binding]; other site 114615004282 quinoprotein dehydrogenase-associated probable ABC transporter substrate-binding protein; Region: ABC_peri_MoxJ_2; TIGR03871 114615004283 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 114615004284 substrate binding pocket [chemical binding]; other site 114615004285 membrane-bound complex binding site; other site 114615004286 hinge residues; other site 114615004287 Cytochrome c; Region: Cytochrom_C; pfam00034 114615004288 PQQ-dependent dehydrogenase, methanol/ethanol family; Region: PQQ_enz_alc_DH; TIGR03075 114615004289 PQQ-dependent dehydrogenases and related proteins; Region: PQQ_DH_like; cl11493 114615004290 Trp docking motif [polypeptide binding]; other site 114615004291 active site 114615004292 TPR repeat; Region: TPR_11; pfam13414 114615004293 DNA Polymerase IV/Kappa; Region: PolY_Pol_IV_kappa; cd03586 114615004294 active site 114615004295 DNA polymerase IV; Validated; Region: PRK02406 114615004296 DNA binding site [nucleotide binding] 114615004297 ribonuclease Z; Region: RNase_Z; TIGR02651 114615004298 K+ transporter [Inorganic ion transport and metabolism]; Region: Kup; COG3158 114615004299 potassium uptake protein; Region: kup; TIGR00794 114615004300 chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168 114615004301 Protein of unknown function (DUF1134); Region: DUF1134; pfam06577 114615004302 Ribosomal protein L24e/L24 is a ribosomal protein found in eukaryotes (L24) and in archaea (L24e, distinct from archaeal L24). L24e/L24 is located on the surface of the large subunit, adjacent to proteins L14 and L3, and near the translation factor...; Region: Ribosomal_L24e_L24; cl00909 114615004303 CysQ, a 3'-Phosphoadenosine-5'-phosphosulfate (PAPS) 3'-phosphatase, is a bacterial member of the inositol monophosphatase family. It has been proposed that CysQ helps control intracellular levels of PAPS, which is an intermediate in...; Region: CysQ; cd01638 114615004304 active site 114615004305 Uncharacterized protein conserved in bacteria (DUF2328); Region: DUF2328; pfam10090 114615004306 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 114615004307 putative binding surface; other site 114615004308 active site 114615004309 Chemotaxis protein histidine kinase and related kinases [Cell motility and secretion / Signal transduction mechanisms]; Region: CheA; COG0643 114615004310 Signal transducing histidine kinase, homodimeric domain; Region: H-kinase_dim; pfam02895 114615004311 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 114615004312 ATP binding site [chemical binding]; other site 114615004313 Mg2+ binding site [ion binding]; other site 114615004314 G-X-G motif; other site 114615004315 CheA regulatory domain; CheA is a histidine protein kinase present in bacteria and archea. Activated by the chemotaxis receptor a histidine phosphoryl group from CheA is passed directly to an aspartate in the response regulator CheY. This signalling...; Region: CheA_reg; cd00731 114615004316 CheW-like domain; Region: CheW; pfam01584 114615004317 Response regulator receiver domain; Region: Response_reg; pfam00072 114615004318 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 114615004319 active site 114615004320 phosphorylation site [posttranslational modification] 114615004321 intermolecular recognition site; other site 114615004322 dimerization interface [polypeptide binding]; other site 114615004323 CheW-like domain. CheW proteins are part of the chemotaxis signalling mechanism in bacteria. CheW interacts with the methyl accepting chemotaxis proteins (MCPs) and relays signals to CheY, which affects flageller rotation. This family includes CheW and...; Region: CheW_like; cl00256 114615004324 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 114615004325 Response regulator receiver domain; Region: Response_reg; pfam00072 114615004326 active site 114615004327 phosphorylation site [posttranslational modification] 114615004328 intermolecular recognition site; other site 114615004329 dimerization interface [polypeptide binding]; other site 114615004330 chemotaxis-specific methylesterase; Provisional; Region: PRK00742 114615004331 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 114615004332 active site 114615004333 phosphorylation site [posttranslational modification] 114615004334 intermolecular recognition site; other site 114615004335 dimerization interface [polypeptide binding]; other site 114615004336 CheB methylesterase; Region: CheB_methylest; pfam01339 114615004337 CheR methyltransferase, all-alpha domain; Region: CheR_N; pfam03705 114615004338 Methylase of chemotaxis methyl-accepting proteins [Cell motility and secretion / Signal transduction mechanisms]; Region: CheR; COG1352 114615004339 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 114615004340 S-adenosylmethionine binding site [chemical binding]; other site 114615004341 circadian clock protein KaiC; Reviewed; Region: PRK09302 114615004342 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 114615004343 Walker A motif; other site 114615004344 ATP binding site [chemical binding]; other site 114615004345 Walker B motif; other site 114615004346 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 114615004347 Walker A motif; other site 114615004348 ATP binding site [chemical binding]; other site 114615004349 Walker B motif; other site 114615004350 KaiB-like family; composed of the circadian clock proteins, KaiB and the N-terminal KaiB-like sensory domain of SasA. KaiB is an essential protein in maintaining circadian rhythm. It was originally discovered from the cyanobacterium Synechococcus as part...; Region: KaiB_like; cd02978 114615004351 tetramer interface [polypeptide binding]; other site 114615004352 dimer interface [polypeptide binding]; other site 114615004353 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 114615004354 FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202 114615004355 putative active site [active] 114615004356 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459 114615004357 putative active site [active] 114615004358 heme pocket [chemical binding]; other site 114615004359 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920 114615004360 HWE histidine kinase; Region: HWE_HK; pfam07536 114615004361 cheY-homologous receiver domain; Region: REC; smart00448 114615004362 Response regulator receiver domain; Region: Response_reg; pfam00072 114615004363 active site 114615004364 phosphorylation site [posttranslational modification] 114615004365 intermolecular recognition site; other site 114615004366 dimerization interface [polypeptide binding]; other site 114615004367 Glutathionylspermidine synthase [Amino acid transport and metabolism]; Region: Gsp; COG0754 114615004368 Predicted membrane protein [Function unknown]; Region: COG3766 114615004369 Transcriptional regulators [Transcription]; Region: GntR; COG1802 114615004370 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 114615004371 DNA-binding site [nucleotide binding]; DNA binding site 114615004372 FCD domain; Region: FCD; pfam07729 114615004373 NMT1-like family; Region: NMT1_2; pfam13379 114615004374 ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components [Inorganic ion transport and metabolism]; Region: TauA; COG0715 114615004375 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 114615004376 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 114615004377 dimer interface [polypeptide binding]; other site 114615004378 conserved gate region; other site 114615004379 putative PBP binding loops; other site 114615004380 ABC-ATPase subunit interface; other site 114615004381 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 114615004382 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 114615004383 Walker A/P-loop; other site 114615004384 ATP binding site [chemical binding]; other site 114615004385 Q-loop/lid; other site 114615004386 ABC transporter signature motif; other site 114615004387 Walker B; other site 114615004388 D-loop; other site 114615004389 H-loop/switch region; other site 114615004390 Asp/Glu/Hydantoin racemase; Region: Asp_Glu_race; cl00518 114615004391 dihydropyrimidinase; Provisional; Region: PRK13404 114615004392 D-hydantoinases (D-HYD) also called dihydropyrimidases (DHPase) and related proteins; DHPases are a family of enzymes that catalyze the reversible hydrolytic ring opening of the amide bond in five- or six-membered cyclic diamides, like dihydropyrimidine...; Region: D-HYD; cd01314 114615004393 tetramer interface [polypeptide binding]; other site 114615004394 active site 114615004395 Catalytic domain of phospholipase D superfamily proteins; Region: PLDc_SF; cl15239 114615004396 PLD-like domain; Region: PLDc_2; pfam13091 114615004397 putative active site [active] 114615004398 catalytic site [active] 114615004399 Putative catalytic domain, repeat 2, of uncharacterized hypothetical proteins similar to Nuc, an endonuclease from Salmonella typhimurium; Region: PLDc_Nuc_like_unchar1_2; cd09173 114615004400 Phosphatidylserine/phosphatidylglycerophosphate/car diolipin synthases and related enzymes [Lipid metabolism]; Region: Cls; COG1502 114615004401 putative active site [active] 114615004402 catalytic site [active] 114615004403 OstA-like protein; Region: OstA; pfam03968 114615004404 Cytochrome c; Region: Cytochrom_C; pfam00034 114615004405 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 114615004406 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 114615004407 active site 114615004408 phosphorylation site [posttranslational modification] 114615004409 intermolecular recognition site; other site 114615004410 dimerization interface [polypeptide binding]; other site 114615004411 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 114615004412 DNA binding site [nucleotide binding] 114615004413 flagellum-specific ATP synthase; Validated; Region: fliI; PRK08927 114615004414 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 114615004415 Flagellum-specific ATPase/type III secretory pathway virulence-related protein. This group of ATPases are responsible for the export of flagellum and virulence-related proteins. The bacterial flagellar motor is similar to the F0F1-ATPase, in that they...; Region: ATPase_flagellum-secretory_path_III; cd01136 114615004416 Walker A motif/ATP binding site; other site 114615004417 Walker B motif; other site 114615004418 flagellar export protein FliJ; Region: flagell_FliJ; TIGR02473 114615004419 RNA polymerase sigma factor; Provisional; Region: PRK12514 114615004420 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 114615004421 Sigma-70, region 4; Region: Sigma70_r4_2; pfam08281 114615004422 DNA binding residues [nucleotide binding] 114615004423 Anti-sigma-K factor rskA; Region: RskA; pfam10099 114615004424 flagellar biosynthesis protein FlhA; Validated; Region: flhA; PRK06012 114615004425 FHIPEP family; Region: FHIPEP; pfam00771 114615004426 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312 114615004427 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 114615004428 substrate binding pocket [chemical binding]; other site 114615004429 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 114615004430 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 114615004431 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 114615004432 binding surface 114615004433 TPR repeat; Region: TPR_11; pfam13414 114615004434 TPR motif; other site 114615004435 TPR repeat; Region: TPR_11; pfam13414 114615004436 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 114615004437 binding surface 114615004438 TPR motif; other site 114615004439 TPR repeat; Region: TPR_11; pfam13414 114615004440 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 114615004441 binding surface 114615004442 TPR motif; other site 114615004443 Predicted O-linked N-acetylglucosamine transferase, SPINDLY family [Posttranslational modification, protein turnover, chaperones]; Region: Spy; COG3914 114615004444 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 114615004445 Coenzyme A binding pocket [chemical binding]; other site 114615004446 shikimate kinase; Reviewed; Region: aroK; PRK00131 114615004447 AAA domain; Region: AAA_17; pfam13207 114615004448 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 114615004449 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 114615004450 dimer interface [polypeptide binding]; other site 114615004451 putative CheW interface [polypeptide binding]; other site 114615004452 Copper binding periplasmic protein CusF; Region: CusF_Ec; pfam11604 114615004453 Putative multicopper oxidases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: SufI; COG2132 114615004454 Multicopper oxidase; Region: Cu-oxidase_3; pfam07732 114615004455 Multicopper oxidase; Region: Cu-oxidase_2; pfam07731 114615004456 Outer membrane protein [Cell envelope biogenesis, outer membrane / Intracellular trafficking and secretion]; Region: TolC; COG1538 114615004457 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 114615004458 Major Facilitator Superfamily; Region: MFS_1; pfam07690 114615004459 putative substrate translocation pore; other site 114615004460 TRAP transporter solute receptor, TAXI family; Region: TRAP_TAXI; TIGR02122 114615004461 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 114615004462 kynureninase; Region: kynureninase; TIGR01814 114615004463 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 114615004464 catalytic residue [active] 114615004465 tryptophan 2,3-dioxygenase; Region: trp_2_3_diox; TIGR03036 114615004466 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 114615004467 amidase; Provisional; Region: PRK07235 114615004468 Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154 114615004469 2-haloalkanoic acid dehalogenase, type II; Region: HAD_type_II; TIGR01428 114615004470 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 114615004471 motif I; other site 114615004472 motif II; other site 114615004473 Transcriptional regulator [Transcription]; Region: LysR; COG0583 114615004474 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 114615004475 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 114615004476 dimerization interface [polypeptide binding]; other site 114615004477 Gamma-glutamyltransferase [Amino acid transport and metabolism]; Region: Ggt; cl08040 114615004478 Gamma-glutamyltranspeptidase; Region: G_glu_transpept; pfam01019 114615004479 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 114615004480 homotrimer interaction site [polypeptide binding]; other site 114615004481 putative active site [active] 114615004482 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 114615004483 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 114615004484 Predicted acetamidase/formamidase [Energy production and conversion]; Region: COG2421 114615004485 Predicted acetamidase/formamidase [Energy production and conversion]; Region: COG2421 114615004486 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 114615004487 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 114615004488 dimer interface [polypeptide binding]; other site 114615004489 conserved gate region; other site 114615004490 putative PBP binding loops; other site 114615004491 ABC-ATPase subunit interface; other site 114615004492 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 114615004493 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 114615004494 Walker A/P-loop; other site 114615004495 ATP binding site [chemical binding]; other site 114615004496 Q-loop/lid; other site 114615004497 ABC transporter signature motif; other site 114615004498 Walker B; other site 114615004499 D-loop; other site 114615004500 H-loop/switch region; other site 114615004501 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 114615004502 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 114615004503 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 114615004504 substrate binding pocket [chemical binding]; other site 114615004505 membrane-bound complex binding site; other site 114615004506 hinge residues; other site 114615004507 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 114615004508 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 114615004509 dimer interface [polypeptide binding]; other site 114615004510 conserved gate region; other site 114615004511 putative PBP binding loops; other site 114615004512 ABC-ATPase subunit interface; other site 114615004513 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 114615004514 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 114615004515 Walker A/P-loop; other site 114615004516 ATP binding site [chemical binding]; other site 114615004517 Q-loop/lid; other site 114615004518 ABC transporter signature motif; other site 114615004519 Walker B; other site 114615004520 D-loop; other site 114615004521 H-loop/switch region; other site 114615004522 TOBE domain; Region: TOBE_2; pfam08402 114615004523 Spermidine/putrescine-binding periplasmic protein [Amino acid transport and metabolism]; Region: PotD; COG0687 114615004524 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 114615004525 ABC-type Fe3+ transport system, permease component [Inorganic ion transport and metabolism]; Region: ThiP; COG1178 114615004526 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 114615004527 dimer interface [polypeptide binding]; other site 114615004528 conserved gate region; other site 114615004529 putative PBP binding loops; other site 114615004530 ABC-ATPase subunit interface; other site 114615004531 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 114615004532 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 114615004533 active site 114615004534 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 114615004535 Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; pfam07683 114615004536 Transcriptional regulator [Transcription]; Region: IclR; COG1414 114615004537 IclR helix-turn-helix domain; Region: HTH_IclR; pfam09339 114615004538 Bacterial transcriptional regulator; Region: IclR; pfam01614 114615004539 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 114615004540 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 114615004541 Walker A/P-loop; other site 114615004542 ATP binding site [chemical binding]; other site 114615004543 Q-loop/lid; other site 114615004544 ABC transporter signature motif; other site 114615004545 Walker B; other site 114615004546 D-loop; other site 114615004547 H-loop/switch region; other site 114615004548 TOBE domain; Region: TOBE_2; pfam08402 114615004549 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 114615004550 dimer interface [polypeptide binding]; other site 114615004551 conserved gate region; other site 114615004552 putative PBP binding loops; other site 114615004553 ABC-ATPase subunit interface; other site 114615004554 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 114615004555 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 114615004556 dimer interface [polypeptide binding]; other site 114615004557 ABC-ATPase subunit interface; other site 114615004558 putative PBP binding loops; other site 114615004559 2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_4; pfam13510 114615004560 Uncharacterized NAD(FAD)-dependent dehydrogenases [General function prediction only]; Region: HcaD; COG0446 114615004561 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 114615004562 Spermidine/putrescine-binding periplasmic protein [Amino acid transport and metabolism]; Region: PotD; COG0687 114615004563 ABC-type Fe3+ transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: AfuA; COG1840 114615004564 Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_ox_2; pfam12900 114615004565 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 114615004566 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 114615004567 DNA-binding site [nucleotide binding]; DNA binding site 114615004568 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 114615004569 pyridoxal 5'-phosphate binding site [chemical binding]; other site 114615004570 homodimer interface [polypeptide binding]; other site 114615004571 catalytic residue [active] 114615004572 Beta-lactamase superfamily domain; Region: Lactamase_B_2; pfam12706 114615004573 Peptidase M4 family containing mostly uncharacterized proteins; Region: M4_uncharacterized; cd09598 114615004574 Zn binding site [ion binding]; other site 114615004575 Patatin-like phospholipase; Region: Patatin; pfam01734 114615004576 active site 114615004577 nucleophile elbow; other site 114615004578 Class II Aldolase and Adducin N-terminal domain; Region: Aldolase_II; pfam00596 114615004579 active site 114615004580 intersubunit interface [polypeptide binding]; other site 114615004581 Zn2+ binding site [ion binding]; other site 114615004582 Domains similar to fish antifreeze type III protein; Region: SAF_AH_GD; cd11613 114615004583 galactarate dehydratase; Region: galactar-dH20; TIGR03248 114615004584 D-galactarate dehydratase / Altronate hydrolase, C terminus; Region: GD_AH_C; pfam04295 114615004585 Bacillus subtilis NADP+-dependent alpha-ketoglutaric semialdehyde dehydrogenase ycbD-like; Region: ALDH_KGSADH-YcbD; cd07097 114615004586 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 114615004587 NAD(P) binding site [chemical binding]; other site 114615004588 catalytic residues [active] 114615004589 glucarate dehydratase; Region: glucar-dehydr; TIGR03247 114615004590 D-Glucarate dehydratase (GlucD) catalyzes the dehydration of both D-glucarate and L-idarate to form 5-keto-4-deoxy-D-glucarate (5-KDG) , the initial reaction of the catabolic pathway for (D)-glucarate. GlucD belongs to the enolase superfamily of enzymes; Region: D-glucarate_dehydratase; cd03323 114615004591 active site 114615004592 tetramer interface [polypeptide binding]; other site 114615004593 Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329 114615004594 5-dehydro-4-deoxyglucarate dehydratase, also called 5-keto-4-deoxy-glucarate dehydratase (KDGDH); Region: KDGDH; cd00951 114615004595 putative active site [active] 114615004596 catalytic residue [active] 114615004597 DNA-binding transcriptional regulator HcaR; Provisional; Region: PRK09906 114615004598 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 114615004599 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator similar to regulators involved in the catabolism of aromatic compounds, contains type 2 periplasmic binding fold; Region: PBP2_LTTR_aromatics_like_1; cd08447 114615004600 putative dimerization interface [polypeptide binding]; other site 114615004601 putative substrate binding pocket [chemical binding]; other site 114615004602 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 114615004603 D-galactonate transporter; Region: 2A0114; TIGR00893 114615004604 putative substrate translocation pore; other site 114615004605 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 114615004606 Histone deacetylase class IIa; Region: HDAC_classII_APAH; cd10001 114615004607 Deacetylases, including yeast histone deacetylase and acetoin utilization protein [Chromatin structure and dynamics / Secondary metabolites biosynthesis, transport, and catabolism]; Region: AcuC; COG0123 114615004608 active site 114615004609 Zn binding site [ion binding]; other site 114615004610 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 114615004611 dimerization interface [polypeptide binding]; other site 114615004612 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 114615004613 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 114615004614 dimer interface [polypeptide binding]; other site 114615004615 putative CheW interface [polypeptide binding]; other site 114615004616 phosphoenolpyruvate synthase; Validated; Region: PRK06464 114615004617 Pyruvate phosphate dikinase, PEP/pyruvate binding domain; Region: PPDK_N; pfam01326 114615004618 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 114615004619 PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896 114615004620 ABC transporter transmembrane region 2; Region: ABC_membrane_2; cl00549 114615004621 Fructose-1-phosphate kinase and related fructose-6-phosphate kinase (PfkB) [Carbohydrate transport and metabolism]; Region: FruK; COG1105 114615004622 1-phosphofructokinase (FruK), minor 6-phosphofructokinase (pfkB) and related sugar kinases. FruK plays an important role in the predominant pathway for fructose utilisation.This group also contains tagatose-6-phophate kinase, an enzyme of the tagatose...; Region: FruK_PfkB_like; cd01164 114615004623 putative substrate binding site [chemical binding]; other site 114615004624 putative ATP binding site [chemical binding]; other site 114615004625 Glucokinase; Region: Glucokinase; pfam02685 114615004626 glucokinase, proteobacterial type; Region: glk; TIGR00749 114615004627 beta-galactosidase; Region: BGL; TIGR03356 114615004628 Glycosyl hydrolase family 1; Region: Glyco_hydro_1; cl01046 114615004629 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 114615004630 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 114615004631 dimer interface [polypeptide binding]; other site 114615004632 ABC-ATPase subunit interface; other site 114615004633 putative PBP binding loops; other site 114615004634 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 114615004635 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 114615004636 dimer interface [polypeptide binding]; other site 114615004637 conserved gate region; other site 114615004638 putative PBP binding loops; other site 114615004639 ABC-ATPase subunit interface; other site 114615004640 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 114615004641 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 114615004642 Walker A/P-loop; other site 114615004643 ATP binding site [chemical binding]; other site 114615004644 Q-loop/lid; other site 114615004645 ABC transporter signature motif; other site 114615004646 Walker B; other site 114615004647 D-loop; other site 114615004648 H-loop/switch region; other site 114615004649 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 114615004650 dipeptide transporter ATP-binding subunit; Provisional; Region: dppF; PRK11308 114615004651 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 114615004652 Walker A/P-loop; other site 114615004653 ATP binding site [chemical binding]; other site 114615004654 Q-loop/lid; other site 114615004655 ABC transporter signature motif; other site 114615004656 Walker B; other site 114615004657 D-loop; other site 114615004658 H-loop/switch region; other site 114615004659 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; pfam08352 114615004660 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 114615004661 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_6; cd08494 114615004662 thioredoxin-disulfide reductase; Region: TRX_reduct; TIGR01292 114615004663 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 114615004664 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 114615004665 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 114615004666 dimer interface [polypeptide binding]; other site 114615004667 conserved gate region; other site 114615004668 ABC-ATPase subunit interface; other site 114615004669 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 114615004670 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 114615004671 dimer interface [polypeptide binding]; other site 114615004672 conserved gate region; other site 114615004673 putative PBP binding loops; other site 114615004674 ABC-ATPase subunit interface; other site 114615004675 ABC-type oligopeptide transport system, ATPase component [Amino acid transport and metabolism]; Region: AppF; COG4608 114615004676 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 114615004677 Walker A/P-loop; other site 114615004678 ATP binding site [chemical binding]; other site 114615004679 Q-loop/lid; other site 114615004680 ABC transporter signature motif; other site 114615004681 Walker B; other site 114615004682 D-loop; other site 114615004683 H-loop/switch region; other site 114615004684 oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727 114615004685 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 114615004686 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 114615004687 Walker A/P-loop; other site 114615004688 ATP binding site [chemical binding]; other site 114615004689 Q-loop/lid; other site 114615004690 ABC transporter signature motif; other site 114615004691 Walker B; other site 114615004692 D-loop; other site 114615004693 H-loop/switch region; other site 114615004694 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 114615004695 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_10; cd08515 114615004696 Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496 114615004697 Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261 114615004698 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cl12060 114615004699 Metal-binding active site; metal-binding site 114615004700 Glutamine cyclotransferase [Posttranslational modification, protein turnover, chaperones]; Region: COG3823 114615004701 Bacterial protein of unknown function (DUF899); Region: DUF899; cl17828 114615004702 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 114615004703 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 114615004704 Walker A/P-loop; other site 114615004705 ATP binding site [chemical binding]; other site 114615004706 Q-loop/lid; other site 114615004707 ABC transporter signature motif; other site 114615004708 Walker B; other site 114615004709 D-loop; other site 114615004710 H-loop/switch region; other site 114615004711 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 114615004712 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 114615004713 dimer interface [polypeptide binding]; other site 114615004714 conserved gate region; other site 114615004715 putative PBP binding loops; other site 114615004716 ABC-ATPase subunit interface; other site 114615004717 ABC transporter, substrate-binding protein, aliphatic sulfonates family; Region: SsuA_fam; TIGR01728 114615004718 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 114615004719 substrate binding pocket [chemical binding]; other site 114615004720 membrane-bound complex binding site; other site 114615004721 hinge residues; other site 114615004722 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 114615004723 DNA-binding site [nucleotide binding]; DNA binding site 114615004724 histidine utilization repressor, proteobacterial; Region: his_ut_repres; TIGR02018 114615004725 UTRA domain; Region: UTRA; pfam07702 114615004726 N-formimino-L-glutamate deiminase; Validated; Region: PRK09229 114615004727 Metallo-dependent hydrolases, subgroup D is part of the superfamily of metallo-dependent hydrolases, a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the...; Region: Met_dep_hydrolase_E; cd01313 114615004728 active site 114615004729 imidazolonepropionase; Validated; Region: PRK09356 114615004730 Imidazolonepropionase/imidazolone-5-propionate hydrolase (Imidazolone-5PH) catalyzes the third step in the histidine degradation pathway, the hydrolysis of (S)-3-(5-oxo-4,5-dihydro-3H-imidazol-4-yl)propanoate to N-formimidoyl-L-glutamate. In bacteria; Region: Imidazolone-5PH; cd01296 114615004731 active site 114615004732 Phenylalanine ammonia-lyase (PAL) and histidine ammonia-lyase (HAL); Region: PAL-HAL; cd00332 114615004733 active sites [active] 114615004734 tetramer interface [polypeptide binding]; other site 114615004735 urocanate hydratase; Provisional; Region: PRK05414 114615004736 magnesium chelatase subunit I; Provisional; Region: bchI; PRK13407 114615004737 Magnesium chelatase, subunit ChlI; Region: Mg_chelatase; pfam01078 114615004738 magnesium chelatase subunit D; Provisional; Region: bchD; PRK13406 114615004739 Magnesium chelatase: Mg-chelatase catalyses the insertion of Mg into protoporphyrin IX (Proto). In chlorophyll biosynthesis, insertion of Mg2+ into protoporphyrin IX is catalysed by magnesium chelatase in an ATP-dependent reaction. Magnesium chelatase is...; Region: vWA_Magnesium_chelatase; cd01451 114615004740 metal ion-dependent adhesion site (MIDAS); other site 114615004741 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 114615004742 putative magnesium chelatase accessory protein; Region: bchO_mg_che_rel; TIGR03056 114615004743 phytoene desaturase; Region: crtI_fam; TIGR02734 114615004744 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 114615004745 Trans-Isoprenyl Diphosphate Synthases, head-to-head; Region: Trans_IPPS_HH; cd00683 114615004746 active site lid residues [active] 114615004747 substrate binding pocket [chemical binding]; other site 114615004748 catalytic residues [active] 114615004749 substrate-Mg2+ binding site; other site 114615004750 aspartate-rich region 1; other site 114615004751 aspartate-rich region 2; other site 114615004752 Hydroxyneurosporene synthase (CrtC); Region: CrtC; pfam07143 114615004753 phytoene desaturase; Region: crtI_fam; TIGR02734 114615004754 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 114615004755 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 114615004756 substrate binding pocket [chemical binding]; other site 114615004757 chain length determination region; other site 114615004758 substrate-Mg2+ binding site; other site 114615004759 catalytic residues [active] 114615004760 aspartate-rich region 1; other site 114615004761 active site lid residues [active] 114615004762 aspartate-rich region 2; other site 114615004763 O-methyltransferase; Region: Methyltransf_2; pfam00891 114615004764 2-desacetyl-2-hydroxyethyl bacteriochlorophyllide A dehydrogenase; Region: bchC; TIGR01202 114615004765 2-desacetyl-2-hydroxyethyl bacteriochlorophyllide and other MDR family members; Region: 2-desacetyl-2-hydroxyethyl_bacteriochlorophyllide_; cd08255 114615004766 putative NAD(P) binding site [chemical binding]; other site 114615004767 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 114615004768 chlorophyllide reductase iron protein subunit X; Region: BchX; TIGR02016 114615004769 Chlide_reductase_Y : Y subunit of chlorophyllide (chlide) reductase (BchY). Chlide reductase participates in photosynthetic pigment synthesis playing a role in the conversion of chlorophylls(Chl) into bacteriochlorophylls (BChl). Chlide reductase...; Region: Chlide_reductase_Y; cd01980 114615004770 chlorophyllide reductase subunit Y; Region: BchY; TIGR02015 114615004771 The nitrogenase enzyme system catalyzes the ATP-dependent reduction of dinitrogen to ammonia. This group contains both alpha and beta subunits of component 1 of the three known genetically distinct types of nitrogenase systems: a molybdenum-dependent; Region: Oxidoreductase_nitrogenase; cl02775 114615004772 chlorophyllide reductase subunit Z; Region: BchZ; TIGR02014 114615004773 Proto-chlorophyllide reductase 57 kD subunit; Region: PCP_red; pfam08369 114615004774 Antenna complex alpha/beta subunit; Region: LHC; pfam00556 114615004775 Antenna complex alpha/beta subunit; Region: LHC; pfam00556 114615004776 Subunit L of bacterial photosynthetic reaction center; Region: Photo-RC_L; cd09290 114615004777 subunit M interface; other site 114615004778 subunit H interface; other site 114615004779 quinone binding site; other site 114615004780 bacteriopheophytin binding site; other site 114615004781 bacteriochlorophyll binding site; other site 114615004782 cytochrome C subunit interface; other site 114615004783 Fe binding site [ion binding]; other site 114615004784 Subunit M of bacterial photosynthetic reaction center; Region: Photo-RC_M; cd09291 114615004785 subunit H interface; other site 114615004786 subunit L interface; other site 114615004787 bacteriopheophytin binding site; other site 114615004788 carotenoid binding site; other site 114615004789 bacteriochlorophyll binding site; other site 114615004790 cytochrome C interface; other site 114615004791 quinone binding site; other site 114615004792 Fe binding site [ion binding]; other site 114615004793 Heme oxygenase catalyzes the rate limiting step in the degradation of heme to bilirubin, it is essential for recycling of iron from heme. Heme is used as a substrate and cofactor for its own degradation to biliverdin, iron, and carbon monoxide. This...; Region: HemeO; cd00232 114615004794 heme binding pocket [chemical binding]; other site 114615004795 heme ligand [chemical binding]; other site 114615004796 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3666 114615004797 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 114615004798 Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751 114615004799 PAS fold; Region: PAS_2; pfam08446 114615004800 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 114615004801 GAF domain; Region: GAF; pfam01590 114615004802 Phytochrome region; Region: PHY; pfam00360 114615004803 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 114615004804 PAS domain; Region: PAS_9; pfam13426 114615004805 putative active site [active] 114615004806 heme pocket [chemical binding]; other site 114615004807 transcriptional regulator PpsR; Region: PpsR-CrtJ; TIGR02040 114615004808 PAS domain; Region: PAS; smart00091 114615004809 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 114615004810 putative active site [active] 114615004811 heme pocket [chemical binding]; other site 114615004812 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 114615004813 Cytochrome c; Region: Cytochrom_C; cl11414 114615004814 putative heme-binding domain, Pirellula/Verrucomicrobium type; Region: CxxCH_TIGR02603 114615004815 geranylgeranyl reductase; Region: BchP-ChlP; TIGR02023 114615004816 PUCC protein; Region: PUCC; pfam03209 114615004817 bacteriochlorophyll/chlorophyll a synthase; Reviewed; Region: PRK07566 114615004818 UbiA prenyltransferase family; Region: UbiA; pfam01040 114615004819 transcriptional regulator PpsR; Region: PpsR-CrtJ; TIGR02040 114615004820 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 114615004821 putative active site [active] 114615004822 heme pocket [chemical binding]; other site 114615004823 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 114615004824 B12 binding domain (B12-BD). Most of the members bind different cobalamid derivates, like B12 (adenosylcobamide) or methylcobalamin or methyl-Co(III) 5-hydroxybenzimidazolylcobamide. This domain is found in several enzymes, such as glutamate mutase; Region: B12-binding_like; cl00293 114615004825 2-vinyl bacteriochlorophyllide hydratase (BCHF); Region: BCHF; pfam07284 114615004826 light-independent protochlorophyllide reductase subunit N; Provisional; Region: PRK02842 114615004827 light-independent protochlorophyllide reductase, N subunit; Region: DPOR_bchN; TIGR01279 114615004828 light-independent protochlorophyllide reductase subunit B; Provisional; Region: PRK02910 114615004829 Pchlide_reductase_B: B protein of the NB protein complex of Protochlorophyllide (Pchlide)_reductase. Pchlide reductase catalyzes the reductive formation of chlorophyllide (chlide) from protochlorophyllide (pchlide) during biosynthesis of chlorophylls and...; Region: Pchlide_reductase_B; cd01981 114615004830 Proto-chlorophyllide reductase 57 kD subunit; Region: PCP_red; pfam08369 114615004831 magnesium chelatase subunit H; Provisional; Region: bchH; PRK13405 114615004832 CobN subunit of cobaltochelatase, bchH and chlH subunits of magnesium chelatases, and similar proteins; Region: CobN_like; cd10150 114615004833 protochlorophyllide reductase iron-sulfur ATP-binding protein; Provisional; Region: chlL; PRK13185 114615004834 This family of proteins contains bchL and chlL. Protochlorophyllide reductase catalyzes the reductive formation of chlorophyllide from protochlorophyllide during biosynthesis of chlorophylls and bacteriochlorophylls. Three genes, bchL, bchN and bchB, are...; Region: Bchl_like; cd02032 114615004835 P-loop; other site 114615004836 Mg-protoporphyrin IX methyl transferase; Validated; Region: PRK07580 114615004837 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 114615004838 S-adenosylmethionine binding site [chemical binding]; other site 114615004839 Magnesium-protoporphyrin IX methyltransferase C-terminus; Region: Mg-por_mtran_C; pfam07109 114615004840 PUCC protein; Region: PUCC; pfam03209 114615004841 photosynthetic reaction center, subunit H, bacterial; Region: puhA; TIGR01150 114615004842 Photosynthetic reaction center (RC) complex, subunit H; RC is an integral membrane protein-pigment complex which catalyzes light-induced reduction of ubiquinone to ubiquinol, generating a transmembrane electrochemical gradient of protons used to produce...; Region: PRCH; cl17581 114615004843 subunit M interaction residues [polypeptide binding]; other site 114615004844 subunit L interaction residues [polypeptide binding]; other site 114615004845 putative proton transfer pathway, P1; other site 114615004846 putative proton transfer pathway, P2; other site 114615004847 putative photosynthetic complex assembly protein; Region: photo_alph_chp1; TIGR03054 114615004848 Aerobic Cyclase System Fe-containing subunit (ACSF), ferritin-like diiron-binding domain; Region: ACSF; cd01047 114615004849 diiron binding motif [ion binding]; other site 114615004850 Protein of unknown function (DUF3623); Region: DUF3623; pfam12291 114615004851 pyridoxal phosphate-dependent acyltransferase, putative; Region: gly_Cac_T_rel; TIGR01825 114615004852 KBL_like; this family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to serine palmitoyltransferase (SPT), 5-aminolevulinate synthase (ALAS); Region: KBL_like; cd06454 114615004853 substrate-cofactor binding pocket; other site 114615004854 pyridoxal 5'-phosphate binding site [chemical binding]; other site 114615004855 catalytic residue [active] 114615004856 magnesium-protoporphyrin IX monomethyl ester anaerobic oxidative cyclase; Region: BchE; TIGR02026 114615004857 B12 binding domain_like associated with radical SAM domain. This domain shows similarity with B12 (adenosylcobamide) binding domains found in several enzymes, such as glutamate mutase, methionine synthase and methylmalonyl-CoA mutase, but it lacks the...; Region: radical_SAM_B12_BD; cd02068 114615004858 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 114615004859 FeS/SAM binding site; other site 114615004860 V4R domain; Region: V4R; cl15268 114615004861 Transcriptional regulator [Transcription]; Region: LysR; COG0583 114615004862 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 114615004863 The C-terminal substrate binding of LysR-type transcriptional regulator (CbbR) of RubisCO operon, which is involved in the carbon dioxide fixation, contains the type 2 periplasmic binding fold; Region: PBP2_CbbR_RubisCO_like; cd08419 114615004864 putative dimerization interface [polypeptide binding]; other site 114615004865 Fructose-1,6-bisphosphatase, an enzyme that catalyzes the hydrolysis of fructose-1,6-biphosphate into fructose-6-phosphate and is critical in gluconeogenesis pathway. The alignment model also includes chloroplastic FBPases and sedoheptulose-1; Region: FBPase; cd00354 114615004866 AMP binding site [chemical binding]; other site 114615004867 metal binding site [ion binding]; metal-binding site 114615004868 active site 114615004869 phosphoribulokinase; Provisional; Region: PRK15453 114615004870 Transketolase [Carbohydrate transport and metabolism]; Region: TktA; COG0021 114615004871 Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012 114615004872 TPP-binding site [chemical binding]; other site 114615004873 dimer interface [polypeptide binding]; other site 114615004874 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 114615004875 PYR/PP interface [polypeptide binding]; other site 114615004876 dimer interface [polypeptide binding]; other site 114615004877 TPP binding site [chemical binding]; other site 114615004878 fructose-bisphosphate aldolase; Provisional; Region: PRK09197 114615004879 Tagatose-1,6-bisphosphate (TBP) aldolase and related Type B Class II aldolases. TBP aldolase is a tetrameric class II aldolase that catalyzes the reversible condensation of dihydroxyacetone phosphate with glyceraldehyde 3-phsophate to produce tagatose 1; Region: TBP_aldolase_IIB; cd00947 114615004880 intersubunit interface [polypeptide binding]; other site 114615004881 active site 114615004882 zinc binding site [ion binding]; other site 114615004883 Na+ binding site [ion binding]; other site 114615004884 ribulose bisophosphate carboxylase; Reviewed; Region: rbcL; PRK04208 114615004885 Ribulose bisphosphate carboxylase large chain, Form I; Region: RuBisCO_large_I; cd08212 114615004886 homodimer interface [polypeptide binding]; other site 114615004887 active site 114615004888 heterodimer interface [polypeptide binding]; other site 114615004889 catalytic residue [active] 114615004890 metal binding site [ion binding]; metal-binding site 114615004891 Ribulose bisphosphate carboxylase/oxygenase (Rubisco), small subunit. Rubisco is a bifunctional enzyme catalyzes the initial steps of two opposing metabolic pathways: photosynthetic carbon fixation and the competing process of photorespiration. Rubisco...; Region: RuBisCO_small; cd03527 114615004892 multimerization interface [polypeptide binding]; other site 114615004893 probable Rubsico expression protein CbbX; Region: cbbX_cfxQ; TIGR02880 114615004894 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 114615004895 Walker A motif; other site 114615004896 ATP binding site [chemical binding]; other site 114615004897 Walker B motif; other site 114615004898 arginine finger; other site 114615004899 Predicted phosphatase/phosphohexomutase [General function prediction only]; Region: COG0637 114615004900 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 114615004901 motif II; other site 114615004902 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 114615004903 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 114615004904 Peptidase propeptide and YPEB domain; Region: PepSY; pfam03413 114615004905 Transglycosylase SLT domain; Region: SLT_2; pfam13406 114615004906 murein hydrolase B; Provisional; Region: PRK10760; cl17906 114615004907 catalase/hydroperoxidase HPI(I); Provisional; Region: PRK15061 114615004908 N-terminal catalytic domain of catalase-peroxidases; Region: catalase_peroxidase_1; cd00649 114615004909 dimer interface [polypeptide binding]; other site 114615004910 active site 114615004911 heme binding site [chemical binding]; other site 114615004912 C-terminal non-catalytic domain of catalase-peroxidases; Region: catalase_peroxidase_2; cd08200 114615004913 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 114615004914 DNA-binding transcriptional regulator OxyR; Provisional; Region: PRK11151 114615004915 The C-terminal substrate-binding domain of the LysR-type transcriptional regulator OxyR, a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_OxyR; cd08411 114615004916 dimerization interface [polypeptide binding]; other site 114615004917 Uncharacterized protein family (UPF0150); Region: UPF0150; pfam03681 114615004918 PBP superfamily domain; Region: PBP_like_2; cl17296 114615004919 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 114615004920 dimer interface [polypeptide binding]; other site 114615004921 conserved gate region; other site 114615004922 putative PBP binding loops; other site 114615004923 ABC-ATPase subunit interface; other site 114615004924 phosphate transporter permease subunit PtsA; Provisional; Region: pstA; PRK11268 114615004925 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 114615004926 dimer interface [polypeptide binding]; other site 114615004927 conserved gate region; other site 114615004928 putative PBP binding loops; other site 114615004929 ABC-ATPase subunit interface; other site 114615004930 phosphate transporter ATP-binding protein; Provisional; Region: pstB; PRK10744 114615004931 ATP-binding cassette domain of the phosphate transport system; Region: ABC_PstB_phosphate_transporter; cd03260 114615004932 Walker A/P-loop; other site 114615004933 ATP binding site [chemical binding]; other site 114615004934 Q-loop/lid; other site 114615004935 ABC transporter signature motif; other site 114615004936 Walker B; other site 114615004937 D-loop; other site 114615004938 H-loop/switch region; other site 114615004939 phosphate transport system regulatory protein PhoU; Region: phoU_full; TIGR02135 114615004940 PhoU domain; Region: PhoU; pfam01895 114615004941 PhoU domain; Region: PhoU; pfam01895 114615004942 phosphate regulon transcriptional regulatory protein PhoB; Region: PhoB; TIGR02154 114615004943 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 114615004944 active site 114615004945 phosphorylation site [posttranslational modification] 114615004946 intermolecular recognition site; other site 114615004947 dimerization interface [polypeptide binding]; other site 114615004948 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 114615004949 DNA binding site [nucleotide binding] 114615004950 FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790 114615004951 Sel1-like repeats; Region: SEL1; smart00671 114615004952 Sel1-like repeats; Region: SEL1; smart00671 114615004953 Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad...; Region: Tryp_SPc; cl00149 114615004954 active site 114615004955 substrate binding sites [chemical binding]; other site 114615004956 High-affinity nickel-transport protein; Region: NicO; cl00964 114615004957 NADH ubiquinone oxidoreductase, 20 Kd subunit; Region: Oxidored_q6; pfam01058 114615004958 Ni,Fe-hydrogenase I large subunit [Energy production and conversion]; Region: HyaB; COG0374 114615004959 Coenzyme F420-reducing hydrogenase, alpha subunit [Energy production and conversion]; Region: FrhA; COG3259 114615004960 Nickel-dependent hydrogenase; Region: NiFeSe_Hases; pfam00374 114615004961 Ni,Fe-hydrogenase I small subunit [Energy production and conversion]; Region: HyaA; COG1740 114615004962 NADH ubiquinone oxidoreductase, 20 Kd subunit; Region: Oxidored_q6; pfam01058 114615004963 Ni,Fe-hydrogenase I large subunit [Energy production and conversion]; Region: HyaB; COG0374 114615004964 Nickel-dependent hydrogenase; Region: NiFeSe_Hases; pfam00374 114615004965 Ni/Fe-hydrogenase, b-type cytochrome subunit; Region: CytB-hydogenase; TIGR02125 114615004966 coenzyme F420-reducing hydrogenase delta subunit (putative coenzyme F420 hydrogenase processing subunit); Region: frhD; TIGR00130 114615004967 Endopeptidases belonging to membrane-bound hydrogenases group. These hydrogenases transfer electrons from H2 to a cytochrome that is bound to a membrane-located complex coupling electron transfer to transmembrane proton translocation. Endopeptidase HybD...; Region: H2MP_MemB-H2up; cd06062 114615004968 putative substrate-binding site; other site 114615004969 nickel binding site [ion binding]; other site 114615004970 HupF/HypC family; Region: HupF_HypC; pfam01455 114615004971 HyaE family; HyaE is also called HupG and HoxO. They are proteins serving a critical role in the assembly of multimeric [NiFe] hydrogenases, the enzymes that catalyze the oxidation of molecular hydrogen to enable microorganisms to utilize hydrogen as the...; Region: HyaE; cd02965 114615004972 HupH hydrogenase expression protein, C-terminal conserved region; Region: HupH_C; pfam04809 114615004973 Rubredoxin; nonheme iron binding domains containing a [Fe(SCys)4] center. Rubredoxins are small nonheme iron proteins. The iron atom is coordinated by four cysteine residues (Fe(S-Cys)4), but iron can also be replaced by cobalt, nickel or zinc. They are...; Region: rubredoxin; cd00730 114615004974 Rubredoxin; Region: Rubredoxin; pfam00301 114615004975 iron binding site [ion binding]; other site 114615004976 Protein of unknown function (DUF3457); Region: DUF3457; pfam11939 114615004977 Zn finger protein HypA/HybF (possibly regulating hydrogenase expression) [General function prediction only]; Region: HybF; COG0375 114615004978 Hydrogenase expression/synthesis hypA family; Region: HypA; cl17671 114615004979 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 114615004980 Hydrogenase maturation factor [Posttranslational modification, protein turnover, chaperones]; Region: HypF; COG0068 114615004981 Acylphosphatase; Region: Acylphosphatase; pfam00708 114615004982 HypF finger; Region: zf-HYPF; pfam07503 114615004983 HypF finger; Region: zf-HYPF; pfam07503 114615004984 Telomere recombination; Region: Sua5_yciO_yrdC; pfam01300 114615004985 HupF/HypC family; Region: HupF_HypC; pfam01455 114615004986 hydrogenase isoenzymes formation protein HypD; Provisional; Region: PRK15062 114615004987 hydrogenase expression/formation protein HypD; Region: hypD; TIGR00075 114615004988 HypE (Hydrogenase expression/formation protein). HypE is involved in Ni-Fe hydrogenase biosynthesis. HypE dehydrates its own carbamoyl moiety in an ATP-dependent process to yield the enzyme thiocyanate. The N-terminal domain of HypE is related to the...; Region: HypE; cd02197 114615004989 dimerization interface [polypeptide binding]; other site 114615004990 hydrogenase expression/formation protein HypE; Region: hypE; TIGR02124 114615004991 ATP binding site [chemical binding]; other site 114615004992 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204 114615004993 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 114615004994 active site 114615004995 phosphorylation site [posttranslational modification] 114615004996 intermolecular recognition site; other site 114615004997 dimerization interface [polypeptide binding]; other site 114615004998 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 114615004999 Walker A motif; other site 114615005000 ATP binding site [chemical binding]; other site 114615005001 Walker B motif; other site 114615005002 arginine finger; other site 114615005003 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 114615005004 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 114615005005 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 114615005006 putative active site [active] 114615005007 heme pocket [chemical binding]; other site 114615005008 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 114615005009 dimer interface [polypeptide binding]; other site 114615005010 phosphorylation site [posttranslational modification] 114615005011 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 114615005012 ATP binding site [chemical binding]; other site 114615005013 Mg2+ binding site [ion binding]; other site 114615005014 G-X-G motif; other site 114615005015 Formate/nitrite transporter; Region: Form_Nir_trans; pfam01226 114615005016 Transcriptional regulators [Transcription]; Region: GntR; COG1802 114615005017 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 114615005018 DNA-binding site [nucleotide binding]; DNA binding site 114615005019 FCD domain; Region: FCD; pfam07729 114615005020 Transcriptional regulators [Transcription]; Region: GntR; COG1802 114615005021 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 114615005022 DNA-binding site [nucleotide binding]; DNA binding site 114615005023 FCD domain; Region: FCD; pfam07729 114615005024 Protein of unknown function (DUF461); Region: DUF461; pfam04314 114615005025 PQQ-dependent dehydrogenase, methanol/ethanol family; Region: PQQ_enz_alc_DH; TIGR03075 114615005026 Ethanol dehydrogenase, a bacterial quinoprotein (PQQ-dependent type I alcohol dehydrogenase); Region: PQQ_ADH_I; cd10277 114615005027 dimer interface [polypeptide binding]; other site 114615005028 Trp docking motif [polypeptide binding]; other site 114615005029 active site 114615005030 Cytochrome c; Region: Cytochrom_C; cl11414 114615005031 coenzyme PQQ synthesis protein PqqA; Provisional; Region: pqqA; PRK00284 114615005032 Aerobic-type carbon monoxide dehydrogenase, small subunit CoxS/CutS homologs [Energy production and conversion]; Region: CoxS; COG2080 114615005033 2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_3; pfam13085 114615005034 [2Fe-2S] binding domain; Region: Fer2_2; pfam01799 114615005035 Aerobic-type carbon monoxide dehydrogenase, large subunit CoxL/CutL homologs [Energy production and conversion]; Region: CoxL; COG1529 114615005036 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 114615005037 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; smart01008 114615005038 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 114615005039 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 114615005040 TRAP-type C4-dicarboxylate transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: DctP; COG1638 114615005041 Bacterial extracellular solute-binding protein, family 7; Region: SBP_bac_7; cl15441 114615005042 TRAP-type C4-dicarboxylate transport system, small permease component [Carbohydrate transport and metabolism]; Region: DctM; COG3090 114615005043 DctM-like transporters; Region: DctM; pfam06808 114615005044 TRAP-type C4-dicarboxylate transport system, large permease component [Carbohydrate transport and metabolism]; Region: DctQ; COG1593 114615005045 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK06187 114615005046 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 114615005047 Bacterial Bile acid CoA ligases and similar proteins; Region: BACL_like; cd05929 114615005048 acyl-activating enzyme (AAE) consensus motif; other site 114615005049 acyl-activating enzyme (AAE) consensus motif; other site 114615005050 putative AMP binding site [chemical binding]; other site 114615005051 putative active site [active] 114615005052 putative CoA binding site [chemical binding]; other site 114615005053 Predicted permeases [General function prediction only]; Region: COG0679 114615005054 Thiamine pyrophosphate-requiring enzymes [acetolactate synthase, pyruvate dehydrogenase (cytochrome), glyoxylate carboligase, phosphonopyruvate decarboxylase] [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvB; COG0028 114615005055 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 114615005056 PYR/PP interface [polypeptide binding]; other site 114615005057 dimer interface [polypeptide binding]; other site 114615005058 TPP binding site [chemical binding]; other site 114615005059 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 114615005060 Thiamine pyrophosphate (TPP) family, BZL_OCoD_HPCL subfamily, TPP-binding module; composed of proteins similar to benzaldehyde lyase (BZL), oxalyl-CoA decarboxylase (OCoD) and 2-hydroxyphytanoyl-CoA lyase (2-HPCL). Pseudomonas fluorescens biovar I BZL...; Region: TPP_BZL_OCoD_HPCL; cd02004 114615005061 TPP-binding site; other site 114615005062 dimer interface [polypeptide binding]; other site 114615005063 Major Facilitator Superfamily; Region: MFS_1; pfam07690 114615005064 cytochrome o ubiquinol oxidase subunit II; Region: CyoA; TIGR01433 114615005065 Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; pfam00116 114615005066 COX Aromatic Rich Motif; Region: COX_ARM; pfam06481 114615005067 Heme/copper-type cytochrome/quinol oxidases, subunit 1 [Energy production and conversion]; Region: CyoB; COG0843 114615005068 Ubiquinol oxidase subunit I. Ubiquinol oxidase, the terminal oxidase in the respiratory chains of aerobic bacteria, is a multi-chain transmembrane protein located in the cell membrane. It catalyzes the reduction of O2 and simultaneously pumps protons...; Region: Ubiquinol_Oxidase_I; cd01662 114615005069 D-pathway; other site 114615005070 Putative ubiquinol binding site [chemical binding]; other site 114615005071 Low-spin heme (heme b) binding site [chemical binding]; other site 114615005072 Putative water exit pathway; other site 114615005073 Binuclear center (heme o3/CuB) [ion binding]; other site 114615005074 K-pathway; other site 114615005075 Putative proton exit pathway; other site 114615005076 Ubiquinol oxidase subunit III subfamily. Ubiquinol oxidase, the terminal oxidase in the respiratory chains of aerobic bacteria, is a multi-chain transmembrane protein located in the cell membrane. It catalyzes the reduction of O2 and simultaneously...; Region: Ubiquinol_oxidase_III; cd02863 114615005077 Subunit I/III interface [polypeptide binding]; other site 114615005078 Subunit III/IV interface [polypeptide binding]; other site 114615005079 Heme/copper-type cytochrome/quinol oxidase, subunit 4 [Energy production and conversion]; Region: CyoD; COG3125 114615005080 SURF1 superfamily. Surf1/Shy1 has been implicated in the posttranslational steps of the biogenesis of the mitochondrially-encoded Cox1 subunit of cytochrome c oxidase (complex IV). Cytochrome c oxidase (complex IV), the terminal electron-transferring...; Region: SURF1; cd06662 114615005081 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 114615005082 dimer interface [polypeptide binding]; other site 114615005083 phosphorylation site [posttranslational modification] 114615005084 Histidine kinase-like ATPase domain; Region: HATPase_c_2; pfam13581 114615005085 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 114615005086 ATP binding site [chemical binding]; other site 114615005087 Mg2+ binding site [ion binding]; other site 114615005088 G-X-G motif; other site 114615005089 Response regulator consisting of a CheY-like receiver domain and a Fis-type HTH domain [Signal transduction mechanisms / Transcription]; Region: COG4567 114615005090 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 114615005091 active site 114615005092 phosphorylation site [posttranslational modification] 114615005093 intermolecular recognition site; other site 114615005094 dimerization interface [polypeptide binding]; other site 114615005095 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 114615005096 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4487 114615005097 Uncharacterized protein conserved in bacteria (DUF2130); Region: DUF2130; pfam09903 114615005098 Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841 114615005099 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 114615005100 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 114615005101 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 114615005102 HlyD family secretion protein; Region: HlyD_3; pfam13437 114615005103 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 114615005104 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 114615005105 Protein of unknown function (DUF989); Region: DUF989; pfam06181 114615005106 Predicted membrane protein [Function unknown]; Region: COG3748 114615005107 Cytochrome c; Region: Cytochrom_C; pfam00034 114615005108 xanthine permease; Region: pbuX; TIGR03173 114615005109 Aerobic-type carbon monoxide dehydrogenase, small subunit CoxS/CutS homologs [Energy production and conversion]; Region: CoxS; COG2080 114615005110 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 114615005111 catalytic loop [active] 114615005112 iron binding site [ion binding]; other site 114615005113 [2Fe-2S] binding domain; Region: Fer2_2; pfam01799 114615005114 Aerobic-type carbon monoxide dehydrogenase, large subunit CoxL/CutL homologs [Energy production and conversion]; Region: CoxL; COG1529 114615005115 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; smart01008 114615005116 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 114615005117 FAD binding domain in molybdopterin dehydrogenase; Region: FAD_binding_5; pfam00941 114615005118 hydroxydechloroatrazine ethylaminohydrolase; Reviewed; Region: PRK08203 114615005119 TRZ/ATZ family contains enzymes from the atrazine degradation pathway and related hydrolases. Atrazine, a chlorinated herbizide, can be catabolized by a variety of different bacteria. The first three steps of the atrazine dehalogenation pathway are...; Region: ATZ_TRZ_like; cd01298 114615005120 active site 114615005121 putative substrate binding pocket [chemical binding]; other site 114615005122 dipeptide transporter ATP-binding subunit; Provisional; Region: dppF; PRK11308 114615005123 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 114615005124 Walker A/P-loop; other site 114615005125 ATP binding site [chemical binding]; other site 114615005126 Q-loop/lid; other site 114615005127 ABC transporter signature motif; other site 114615005128 Walker B; other site 114615005129 D-loop; other site 114615005130 H-loop/switch region; other site 114615005131 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 114615005132 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 114615005133 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 114615005134 Walker A/P-loop; other site 114615005135 ATP binding site [chemical binding]; other site 114615005136 Q-loop/lid; other site 114615005137 ABC transporter signature motif; other site 114615005138 Walker B; other site 114615005139 D-loop; other site 114615005140 H-loop/switch region; other site 114615005141 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 114615005142 dipeptide transporter; Provisional; Region: PRK10913 114615005143 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 114615005144 dimer interface [polypeptide binding]; other site 114615005145 conserved gate region; other site 114615005146 putative PBP binding loops; other site 114615005147 ABC-ATPase subunit interface; other site 114615005148 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 114615005149 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 114615005150 dimer interface [polypeptide binding]; other site 114615005151 conserved gate region; other site 114615005152 putative PBP binding loops; other site 114615005153 ABC-ATPase subunit interface; other site 114615005154 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 114615005155 The substrate-binding component of an ABC-type dipeptide import system contains the type 2 periplasmic binding fold; Region: PBP2_DppA_like; cd08493 114615005156 peptide binding site [polypeptide binding]; other site 114615005157 Uncharacterized ABC-type transport system, periplasmic component/surface lipoprotein [General function prediction only]; Region: Med; COG1744 114615005158 Periplasmic binding domain of the basic membrane lipoprotein Med in Bacillus and its close homologs from other bacteria and Archaea; Region: PBP1_BmpA_Med_like; cd06353 114615005159 putative ligand binding site [chemical binding]; other site 114615005160 Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette; Region: TM_PBP1_transp_TpRbsC_like; cd06580 114615005161 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 114615005162 TM-ABC transporter signature motif; other site 114615005163 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 114615005164 Transmembrane subunit (TM) of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which are involved in the uptake of branched-chain amino acids (AAs), as well as TMs of transporters involved in the uptake of...; Region: TM_PBP1_branched-chain-AA_like; cl00454 114615005165 Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette; Region: TM_PBP1_transp_TpRbsC_like; cd06580 114615005166 TM-ABC transporter signature motif; other site 114615005167 ABC-type uncharacterized transport systems, ATPase components [General function prediction only]; Region: COG3845 114615005168 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 114615005169 Walker A/P-loop; other site 114615005170 ATP binding site [chemical binding]; other site 114615005171 Q-loop/lid; other site 114615005172 ABC transporter signature motif; other site 114615005173 Walker B; other site 114615005174 D-loop; other site 114615005175 H-loop/switch region; other site 114615005176 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 114615005177 Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285 114615005178 nucleoside/Zn binding site; other site 114615005179 dimer interface [polypeptide binding]; other site 114615005180 catalytic motif [active] 114615005181 Cation efflux family; Region: Cation_efflux; pfam01545 114615005182 Uncharacterized conserved protein [Function unknown]; Region: COG2155 114615005183 2-keto-3-deoxy-galactonokinase [Carbohydrate transport and metabolism]; Region: DgoK; COG3734 114615005184 2-keto-3-deoxy-galactonokinase; Region: DGOK; pfam05035 114615005185 2-dehydro-3-deoxy-6-phosphogalactonate aldolase; Reviewed; Region: PRK09140 114615005186 KDPG and KHG aldolase; Region: KDPG_aldolase; cd00452 114615005187 active site 114615005188 intersubunit interface [polypeptide binding]; other site 114615005189 catalytic residue [active] 114615005190 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 114615005191 MarR family; Region: MarR_2; pfam12802 114615005192 Fusaric acid resistance protein family; Region: FUSC; pfam04632 114615005193 Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072 114615005194 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738 114615005195 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312 114615005196 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 114615005197 substrate binding pocket [chemical binding]; other site 114615005198 D-3-phosphoglycerate dehydrogenase; Provisional; Region: PRK11790 114615005199 Phosphoglycerate dehydrogenases, NAD-binding and catalytic domains; Region: PGDH_3; cd12176 114615005200 ligand binding site [chemical binding]; other site 114615005201 NAD binding site [chemical binding]; other site 114615005202 tetramer interface [polypeptide binding]; other site 114615005203 catalytic site [active] 114615005204 C-terminal ACT (regulatory) domain of D-3-Phosphoglycerate Dehydrogenase (3PGDH) found in fungi and bacteria; Region: ACT_3PGDH; cd04901 114615005205 L-serine binding site [chemical binding]; other site 114615005206 ACT domain interface; other site 114615005207 TOBE domain; Region: TOBE; cl01440 114615005208 N-terminal domain of molybdenum-binding protein [General function prediction only]; Region: ModE; cl17549 114615005209 Protein of unknown function (DUF2478); Region: DUF2478; pfam10649 114615005210 selenium-dependent molybdenum hydroxylase system protein, YqeB family; Region: matur_yqeB; TIGR03309 114615005211 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 114615005212 molybdenum ABC transporter, ATP-binding protein; Region: modC_ABC; TIGR02142 114615005213 Walker A/P-loop; other site 114615005214 ATP binding site [chemical binding]; other site 114615005215 Q-loop/lid; other site 114615005216 ABC transporter signature motif; other site 114615005217 Walker B; other site 114615005218 D-loop; other site 114615005219 H-loop/switch region; other site 114615005220 TOBE domain; Region: TOBE; cl01440 114615005221 ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555 114615005222 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 114615005223 dimer interface [polypeptide binding]; other site 114615005224 conserved gate region; other site 114615005225 putative PBP binding loops; other site 114615005226 ABC-ATPase subunit interface; other site 114615005227 Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531 114615005228 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 114615005229 amidase; Provisional; Region: PRK07487 114615005230 Amidase; Region: Amidase; cl11426 114615005231 M20 Peptidase Aminoacylase 1-like protein 2 aminobenzoyl-glutamate utilization protein B subfamily; Region: M20_Acy1L2_AbgB; cd05673 114615005232 amidohydrolase; Region: amidohydrolases; TIGR01891 114615005233 putative metal binding site [ion binding]; other site 114615005234 NorE_like subfamily of heme-copper oxidase subunit III. Heme-copper oxidases include cytochrome c and ubiquinol oxidases. Alcaligenes faecalis norE is found in a gene cluster containing norCB. norCB encodes the cytochrome c and cytochrome b subunits of...; Region: NorE_like; cd02862 114615005235 Subunit I/III interface [polypeptide binding]; other site 114615005236 Cytochrome c; Region: Cytochrom_C; pfam00034 114615005237 Cytochrome C and Quinol oxidase polypeptide I; Region: COX1; pfam00115 114615005238 Heme-copper oxidase subunit I. Heme-copper oxidases are transmembrane protein complexes in the respiratory chains of prokaryotes and mitochondria which catalyze the reduction of O2 and simultaneously pump protons across the membrane. The superfamily is...; Region: Heme_Cu_Oxidase_I; cl00275 114615005239 D-pathway; other site 114615005240 K-pathway; other site 114615005241 Binuclear center (active site) [active] 114615005242 Putative proton exit pathway; other site 114615005243 MoxR-like ATPases [General function prediction only]; Region: COG0714 114615005244 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 114615005245 Walker A motif; other site 114615005246 ATP binding site [chemical binding]; other site 114615005247 Walker B motif; other site 114615005248 CbbQ/NirQ/NorQ C-terminal; Region: CbbQ_C; pfam08406 114615005249 Nitric oxide reductase activation protein [Inorganic ion transport and metabolism]; Region: NorD; COG4548 114615005250 norD type: Denitrifying bacteria contain both membrane bound and periplasmic nitrate reductases. Denitrification plays a major role in completing the nitrogen cycle by converting nitrate or nitrite to nitrogen gas. The pathway for microbial...; Region: vWA_norD_type; cd01454 114615005251 metal ion-dependent adhesion site (MIDAS); other site 114615005252 Uncharacterized conserved protein (DUF2267); Region: DUF2267; pfam10025 114615005253 2-oxoacid dehydrogenase subunit E1; Provisional; Region: PRK13012 114615005254 N-carbamyl-D-amino acid amidohydrolase (DCase, class 6 nitrilases); Region: DCase; cd07569 114615005255 Predicted amidohydrolase [General function prediction only]; Region: COG0388 114615005256 tetramer interface [polypeptide binding]; other site 114615005257 active site 114615005258 catalytic triad [active] 114615005259 dimer interface [polypeptide binding]; other site 114615005260 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 114615005261 active site 114615005262 Protein of unknown function (DUF1688); Region: DUF1688; pfam07958 114615005263 hypothetical protein; Validated; Region: PRK07198 114615005264 GTP cyclohydrolase N terminal; Region: GTP_CH_N; pfam12471 114615005265 GTP cyclohydrolase II (RibA). GTP cyclohydrolase II catalyzes the conversion of GTP to 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5' phosphate, formate, pyrophosphate (APy), and GMP in the biosynthetic pathway of riboflavin. Riboflavin is the...; Region: GTP_cyclohydro2; cd00641 114615005266 dimerization interface [polypeptide binding]; other site 114615005267 active site 114615005268 cytosine deaminase; Provisional; Region: PRK05985 114615005269 Bacterial cytosine deaminase and related metal-dependent hydrolases. Cytosine deaminases (CDs) catalyze the deamination of cytosine, producing uracil and ammonia. They play an important role in pyrimidine salvage. CDs are present in prokaryotes and fungi; Region: Bact_CD; cd01293 114615005270 active site 114615005271 N-carbamyl-D-amino acid amidohydrolase (DCase, class 6 nitrilases); Region: DCase; cd07569 114615005272 Predicted amidohydrolase [General function prediction only]; Region: COG0388 114615005273 tetramer interface [polypeptide binding]; other site 114615005274 active site 114615005275 catalytic triad [active] 114615005276 dimer interface [polypeptide binding]; other site 114615005277 Asp/Glu/Hydantoin racemase; Region: Asp_Glu_race; cl00518 114615005278 dihydropyrimidinase; Provisional; Region: PRK13404 114615005279 D-hydantoinases (D-HYD) also called dihydropyrimidases (DHPase) and related proteins; DHPases are a family of enzymes that catalyze the reversible hydrolytic ring opening of the amide bond in five- or six-membered cyclic diamides, like dihydropyrimidine...; Region: D-HYD; cd01314 114615005280 tetramer interface [polypeptide binding]; other site 114615005281 active site 114615005282 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 114615005283 extended (e) SDRs; Region: SDR_e; cd08946 114615005284 NAD(P) binding site [chemical binding]; other site 114615005285 active site 114615005286 substrate binding site [chemical binding]; other site 114615005287 short chain dehydrogenase; Provisional; Region: PRK06138 114615005288 classical (c) SDRs; Region: SDR_c; cd05233 114615005289 NAD(P) binding site [chemical binding]; other site 114615005290 active site 114615005291 DNA-binding transcriptional regulator LysR; Provisional; Region: PRK11013 114615005292 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 114615005293 The C-terminal substrate-domain of LysR-type transcriptional regulators involved in the catabolism of opines and that of related regulators, contains the type 2 periplasmic binding fold; Region: PBP2_LysR_opines_like; cd08415 114615005294 putative dimerization interface [polypeptide binding]; other site 114615005295 FAD dependent oxidoreductase; Region: DAO; pfam01266 114615005296 FAD-NAD(P)-binding; Region: NAD_binding_9; pfam13454 114615005297 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 114615005298 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_7; cd08512 114615005299 Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496 114615005300 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 114615005301 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 114615005302 dimer interface [polypeptide binding]; other site 114615005303 conserved gate region; other site 114615005304 putative PBP binding loops; other site 114615005305 ABC-ATPase subunit interface; other site 114615005306 nickel ABC transporter, permease subunit NikC; Region: nickel_nikC; TIGR02790 114615005307 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 114615005308 dimer interface [polypeptide binding]; other site 114615005309 conserved gate region; other site 114615005310 putative PBP binding loops; other site 114615005311 ABC-ATPase subunit interface; other site 114615005312 ATPase components of various ABC-type transport systems, contain duplicated ATPase [General function prediction only]; Region: COG1123 114615005313 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 114615005314 Walker A/P-loop; other site 114615005315 ATP binding site [chemical binding]; other site 114615005316 Q-loop/lid; other site 114615005317 ABC transporter signature motif; other site 114615005318 Walker B; other site 114615005319 D-loop; other site 114615005320 H-loop/switch region; other site 114615005321 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 114615005322 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 114615005323 Walker A/P-loop; other site 114615005324 ATP binding site [chemical binding]; other site 114615005325 Q-loop/lid; other site 114615005326 ABC transporter signature motif; other site 114615005327 Walker B; other site 114615005328 D-loop; other site 114615005329 H-loop/switch region; other site 114615005330 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 114615005331 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 114615005332 FAD binding domain; Region: FAD_binding_4; pfam01565 114615005333 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 114615005334 putative substrate translocation pore; other site 114615005335 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 114615005336 mannonate dehydratase; Region: uxuA; TIGR00695 114615005337 mannonate dehydratase; Provisional; Region: PRK03906 114615005338 L-idonate 5-dehydrogenase; Provisional; Region: PRK09880 114615005339 L-idonate 5-dehydrogenase; Region: idonate-5-DH; cd08232 114615005340 putative NAD(P) binding site [chemical binding]; other site 114615005341 catalytic Zn binding site [ion binding]; other site 114615005342 2-keto-3-deoxygluconate kinase (KdgK) phosphorylates 2-keto-3-deoxygluconate (KDG) to form 2-keto-3-deoxy-6-phosphogluconate (KDGP). KDG is the common intermediate product, that allows organisms to channel D-glucuronate and/or D-galacturinate into the...; Region: KdgK; cd01166 114615005343 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 114615005344 substrate binding site [chemical binding]; other site 114615005345 ATP binding site [chemical binding]; other site 114615005346 keto-hydroxyglutarate-aldolase/keto-deoxy- phosphogluconate aldolase; Provisional; Region: PRK05718 114615005347 KDPG and KHG aldolase; Region: KDPG_aldolase; cd00452 114615005348 active site 114615005349 intersubunit interface [polypeptide binding]; other site 114615005350 catalytic residue [active] 114615005351 Periplasmic binding domain of ABC-type YtfQ-like transport systems; Region: PBP1_YtfQ_like; cd06309 114615005352 Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407 114615005353 putative ligand binding site [chemical binding]; other site 114615005354 ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129 114615005355 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 114615005356 Walker A/P-loop; other site 114615005357 ATP binding site [chemical binding]; other site 114615005358 Q-loop/lid; other site 114615005359 ABC transporter signature motif; other site 114615005360 Walker B; other site 114615005361 D-loop; other site 114615005362 H-loop/switch region; other site 114615005363 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 114615005364 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 114615005365 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 114615005366 TM-ABC transporter signature motif; other site 114615005367 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 114615005368 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 114615005369 TM-ABC transporter signature motif; other site 114615005370 Transcriptional regulators [Transcription]; Region: FadR; COG2186 114615005371 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 114615005372 DNA-binding site [nucleotide binding]; DNA binding site 114615005373 This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895 114615005374 dihydroxy-acid dehydratase; Validated; Region: PRK06131 114615005375 Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329 114615005376 Dihydrodipicolinate synthase family; Region: DHDPS-like; cd00408 114615005377 inhibitor site; inhibition site 114615005378 active site 114615005379 dimer interface [polypeptide binding]; other site 114615005380 catalytic residue [active] 114615005381 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 114615005382 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 114615005383 galactose mutarotase_like; Region: galactose_mutarotase_like; cd09019 114615005384 active site 114615005385 catalytic residues [active] 114615005386 Gluconolactonase [Carbohydrate transport and metabolism]; Region: COG3386 114615005387 ABC-type xylose transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: XylF; COG4213 114615005388 Periplasmic xylose-binding component of the ABC-type transport systems that belong to a family of pentose/hexose sugar-binding proteins of the type I periplasmic binding protein (PBP1) superfamily; Region: PBP1_ABC_xylose_binding; cd01538 114615005389 putative ligand binding site [chemical binding]; other site 114615005390 ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129 114615005391 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 114615005392 Walker A/P-loop; other site 114615005393 ATP binding site [chemical binding]; other site 114615005394 Q-loop/lid; other site 114615005395 ABC transporter signature motif; other site 114615005396 Walker B; other site 114615005397 D-loop; other site 114615005398 H-loop/switch region; other site 114615005399 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 114615005400 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 114615005401 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 114615005402 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 114615005403 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 114615005404 TM-ABC transporter signature motif; other site 114615005405 Response regulator receiver domain; Region: Response_reg; pfam00072 114615005406 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 114615005407 active site 114615005408 phosphorylation site [posttranslational modification] 114615005409 intermolecular recognition site; other site 114615005410 dimerization interface [polypeptide binding]; other site 114615005411 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 114615005412 Chemotaxis protein histidine kinase and related kinases [Cell motility and secretion / Signal transduction mechanisms]; Region: CheA; COG0643 114615005413 putative binding surface; other site 114615005414 active site 114615005415 Signal transducing histidine kinase, homodimeric domain; Region: H-kinase_dim; pfam02895 114615005416 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 114615005417 ATP binding site [chemical binding]; other site 114615005418 Mg2+ binding site [ion binding]; other site 114615005419 G-X-G motif; other site 114615005420 CheA regulatory domain; CheA is a histidine protein kinase present in bacteria and archea. Activated by the chemotaxis receptor a histidine phosphoryl group from CheA is passed directly to an aspartate in the response regulator CheY. This signalling...; Region: CheA_reg; cd00731 114615005421 CheW, a small regulator protein, unique to the chemotaxis signalling in prokaryotes and archea. CheW interacts with the histidine kinase CheA, most likely with the related regulatory domain of CheA. CheW is proposed to form signalling arrays together...; Region: CheW; cd00732 114615005422 putative CheA interaction surface; other site 114615005423 PAS domain; Region: PAS; smart00091 114615005424 FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202 114615005425 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 114615005426 FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202 114615005427 putative active site [active] 114615005428 heme pocket [chemical binding]; other site 114615005429 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 114615005430 putative active site [active] 114615005431 heme pocket [chemical binding]; other site 114615005432 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 114615005433 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 114615005434 dimer interface [polypeptide binding]; other site 114615005435 putative CheW interface [polypeptide binding]; other site 114615005436 CheR methyltransferase, all-alpha domain; Region: CheR_N; pfam03705 114615005437 Methyltransferase, chemotaxis proteins; Region: MeTrc; smart00138 114615005438 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 114615005439 S-adenosylmethionine binding site [chemical binding]; other site 114615005440 CheD chemotactic sensory transduction; Region: CheD; cl00810 114615005441 chemotaxis-specific methylesterase; Provisional; Region: PRK00742 114615005442 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 114615005443 active site 114615005444 phosphorylation site [posttranslational modification] 114615005445 intermolecular recognition site; other site 114615005446 dimerization interface [polypeptide binding]; other site 114615005447 CheB methylesterase; Region: CheB_methylest; pfam01339 114615005448 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 114615005449 anti sigma factor interaction site; other site 114615005450 regulatory phosphorylation site [posttranslational modification]; other site 114615005451 Histidine kinase-like ATPase domain; Region: HATPase_c_2; pfam13581 114615005452 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075 114615005453 Response regulator receiver domain; Region: Response_reg; pfam00072 114615005454 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 114615005455 active site 114615005456 phosphorylation site [posttranslational modification] 114615005457 intermolecular recognition site; other site 114615005458 dimerization interface [polypeptide binding]; other site 114615005459 Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228 114615005460 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 114615005461 PAS fold; Region: PAS_3; pfam08447 114615005462 putative active site [active] 114615005463 heme pocket [chemical binding]; other site 114615005464 PAS fold; Region: PAS_7; pfam12860 114615005465 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 114615005466 dimer interface [polypeptide binding]; other site 114615005467 phosphorylation site [posttranslational modification] 114615005468 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 114615005469 ATP binding site [chemical binding]; other site 114615005470 Mg2+ binding site [ion binding]; other site 114615005471 G-X-G motif; other site 114615005472 Response regulator receiver domain; Region: Response_reg; pfam00072 114615005473 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 114615005474 active site 114615005475 phosphorylation site [posttranslational modification] 114615005476 intermolecular recognition site; other site 114615005477 dimerization interface [polypeptide binding]; other site 114615005478 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cl00125 114615005479 active site residue [active] 114615005480 Member of the Rhodanese Homology Domain superfamily, repeat 2. This CD includes putative rhodanese-related sulfurtransferases which contain 4 copies of the Rhodanese Homology Domain. This CD aligns the 2nd repeat which does contain the putative catalytic...; Region: 4RHOD_Repeat_2; cd01533 114615005481 active site residue [active] 114615005482 Member of the Rhodanese Homology Domain superfamily, repeat 3. This CD includes putative rhodanese-related sulfurtransferases which contain 4 copies of the Rhodanese Homology Domain. This CD aligns the 3rd repeat which does not contain the putative...; Region: 4RHOD_Repeat_3; cd01534 114615005483 active site residue [active] 114615005484 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cl00125 114615005485 active site residue [active] 114615005486 Predicted metal-dependent enzyme of the double-stranded beta helix superfamily [General function prediction only]; Region: COG5553 114615005487 SnoaL-like domain; Region: SnoaL_3; pfam13474 114615005488 Monoamine oxidase [Amino acid transport and metabolism]; Region: COG1231 114615005489 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 114615005490 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 114615005491 Walker A motif; other site 114615005492 ATP binding site [chemical binding]; other site 114615005493 Walker B motif; other site 114615005494 arginine finger; other site 114615005495 glutathionine S-transferase; Provisional; Region: PRK10542 114615005496 GST_N family, Class Beta subfamily; GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of endogenous and xenobiotic alkylating agents, including carcinogens; Region: GST_N_Beta; cd03057 114615005497 C-terminal domain interface [polypeptide binding]; other site 114615005498 GSH binding site (G-site) [chemical binding]; other site 114615005499 dimer interface [polypeptide binding]; other site 114615005500 C-terminal, alpha helical domain of Class Beta Glutathione S-transferases; Region: GST_C_Beta; cd03188 114615005501 dimer interface [polypeptide binding]; other site 114615005502 substrate binding pocket (H-site) [chemical binding]; other site 114615005503 N-terminal domain interface [polypeptide binding]; other site 114615005504 Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cl00938 114615005505 iron-sulfur cluster [ion binding]; other site 114615005506 [2Fe-2S] cluster binding site [ion binding]; other site 114615005507 GlpE sulfurtransferase (ST) and homologs are members of the Rhodanese Homology Domain superfamily. Unlike other rhodanese sulfurtransferases, GlpE is a single domain protein but indications are that it functions as a dimer. The active site contains a...; Region: GlpE_ST; cd01444 114615005508 active site residue [active] 114615005509 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 114615005510 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 114615005511 This family is the oxydase domain of NRPS (non-ribosomal peptide synthetase) and other proteins that modify polypeptides by cyclizing a thioester to form a ring. These include epoB, part of the epothilone biosynthesis pathway; tubD, part of the tubulysin...; Region: mcbC-like_oxidoreductase; cd02142 114615005512 NADPH bind site [chemical binding]; other site 114615005513 This family is the oxydase domain of NRPS (non-ribosomal peptide synthetase) and other proteins that modify polypeptides by cyclizing a thioester to form a ring. These include epoB, part of the epothilone biosynthesis pathway; tubD, part of the tubulysin...; Region: mcbC-like_oxidoreductase; cd02142 114615005514 putative FMN binding site [chemical binding]; other site 114615005515 NADPH bind site [chemical binding]; other site 114615005516 Flavodoxin reductases (ferredoxin-NADPH reductases) family 1 [Energy production and conversion]; Region: Hmp; COG1018 114615005517 Phthalate dioxygenase reductase (PDR) is an FMN-dependent reductase that mediates electron transfer from NADH to FMN to an iron sulfur cluster. PDR has an an N-terminal ferrredoxin reductase (FNR)-like NAD(H) binding domain and a C-terminal iron-sulfur; Region: PDR_like; cd06185 114615005518 FMN-binding pocket [chemical binding]; other site 114615005519 flavin binding motif; other site 114615005520 phosphate binding motif [ion binding]; other site 114615005521 beta-alpha-beta structure motif; other site 114615005522 NAD binding pocket [chemical binding]; other site 114615005523 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 114615005524 catalytic loop [active] 114615005525 iron binding site [ion binding]; other site 114615005526 PcfJ-like protein; Region: PcfJ; pfam14284 114615005527 protocatechuate 4,5-dioxygenase; Provisional; Region: PRK13367 114615005528 Subunit B of Class III Extradiol ring-cleavage dioxygenases; Region: Extradiol_Dioxygenase_3B_like; cl00599 114615005529 active site 114615005530 metal binding site [ion binding]; metal-binding site 114615005531 The C-terminal domain of Gallate Dioxygenase, which catalyzes the oxidization and subsequent ring-opening of gallate; Region: Gallate_dioxygenase_C; cd07923 114615005532 putative dimer interface [polypeptide binding]; other site 114615005533 putative N- and C-terminal domain interface [polypeptide binding]; other site 114615005534 Transcriptional regulator [Transcription]; Region: LysR; COG0583 114615005535 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 114615005536 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 114615005537 putative effector binding pocket; other site 114615005538 dimerization interface [polypeptide binding]; other site 114615005539 Transcriptional regulator [Transcription]; Region: LysR; COG0583 114615005540 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 114615005541 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator similar to DntR, which is involved in the catabolism of dinitrotoluene; contains the type 2 periplasmic binding fold; Region: PBP2_DntR_like_2; cd08464 114615005542 putative substrate binding pocket [chemical binding]; other site 114615005543 putative dimerization interface [polypeptide binding]; other site 114615005544 Isochorismatase family; Region: Isochorismatase; pfam00857 114615005545 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cl00220 114615005546 catalytic triad [active] 114615005547 conserved cis-peptide bond; other site 114615005548 Methyltransferase domain; Region: Methyltransf_23; pfam13489 114615005549 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 114615005550 S-adenosylmethionine binding site [chemical binding]; other site 114615005551 Escherichia coli PhnB and similar proteins; the E. coli phnB gene is found next to an operon involved in the cleavage of carbon-phosphorus bonds in unactivated alkylphosphonates; Region: PhnB_like; cd06588 114615005552 dimer interface [polypeptide binding]; other site 114615005553 Peptidase family M23; Region: Peptidase_M23; pfam01551 114615005554 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 114615005555 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 114615005556 DNA-binding site [nucleotide binding]; DNA binding site 114615005557 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 114615005558 pyridoxal 5'-phosphate binding site [chemical binding]; other site 114615005559 homodimer interface [polypeptide binding]; other site 114615005560 catalytic residue [active] 114615005561 Uncharacterized Fe-S protein [General function prediction only]; Region: COG3217 114615005562 MOSC N-terminal beta barrel domain; Region: MOSC_N; pfam03476 114615005563 MOSC domain; Region: MOSC; pfam03473 114615005564 Rubredoxin; nonheme iron binding domains containing a [Fe(SCys)4] center. Rubredoxins are small nonheme iron proteins. The iron atom is coordinated by four cysteine residues (Fe(S-Cys)4), but iron can also be replaced by cobalt, nickel or zinc. They are...; Region: rubredoxin; cd00730 114615005565 Rubredoxin; Region: Rubredoxin; pfam00301 114615005566 iron binding site [ion binding]; other site 114615005567 Periplasmic binding protein; Region: Peripla_BP_6; pfam13458 114615005568 Periplasmic component (FmdD) of an active transport system for short-chain amides and urea (FmdDEF); Region: PBP1_FmdD_like; cd06355 114615005569 putative ligand binding site [chemical binding]; other site 114615005570 Group II intron, maturase-specific domain; Region: GIIM; pfam08388 114615005571 SnoaL-like domain; Region: SnoaL_4; pfam13577 114615005572 SnoaL-like domain; Region: SnoaL_3; pfam13474 114615005573 Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638 114615005574 Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cl00938 114615005575 iron-sulfur cluster [ion binding]; other site 114615005576 [2Fe-2S] cluster binding site [ion binding]; other site 114615005577 C-terminal catalytic domain of the oxygenase alpha subunit of dicamba O-demethylase and related aromatic ring hydroxylating dioxygenases; Region: RHO_alpha_C_DMO-like; cd08878 114615005578 alpha subunit interface [polypeptide binding]; other site 114615005579 active site 114615005580 substrate binding site [chemical binding]; other site 114615005581 Fe binding site [ion binding]; other site 114615005582 Transcriptional regulators [Transcription]; Region: FadR; COG2186 114615005583 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 114615005584 DNA-binding site [nucleotide binding]; DNA binding site 114615005585 This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895 114615005586 Flavodoxin reductases (ferredoxin-NADPH reductases) family 1 [Energy production and conversion]; Region: Hmp; COG1018 114615005587 Phthalate dioxygenase reductase (PDR) is an FMN-dependent reductase that mediates electron transfer from NADH to FMN to an iron sulfur cluster. PDR has an an N-terminal ferrredoxin reductase (FNR)-like NAD(H) binding domain and a C-terminal iron-sulfur; Region: PDR_like; cd06185 114615005588 FMN-binding pocket [chemical binding]; other site 114615005589 flavin binding motif; other site 114615005590 phosphate binding motif [ion binding]; other site 114615005591 beta-alpha-beta structure motif; other site 114615005592 NAD binding pocket [chemical binding]; other site 114615005593 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 114615005594 catalytic loop [active] 114615005595 iron binding site [ion binding]; other site 114615005596 methionine synthase; Provisional; Region: PRK01207 114615005597 CIMS - Cobalamine-independent methonine synthase, or MetE, C-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_C_terminal_like; cd03311 114615005598 substrate binding site [chemical binding]; other site 114615005599 THF binding site; other site 114615005600 zinc-binding site [ion binding]; other site 114615005601 acetate kinase A/propionate kinase 2; Reviewed; Region: PRK00180 114615005602 propionate/acetate kinase; Provisional; Region: PRK12379 114615005603 choline dehydrogenase; Validated; Region: PRK02106 114615005604 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 114615005605 porphobilinogen deaminase; Reviewed; Region: hemC; PRK00072 114615005606 Hydroxymethylbilane synthase (HMBS), also known as porphobilinogen deaminase (PBGD), is an intermediate enzyme in the biosynthetic pathway of tetrapyrrolic ring systems, such as heme, chlorophylls, and vitamin B12. HMBS catalyzes the conversion of...; Region: HMBS; cl17708 114615005607 domain interfaces; other site 114615005608 active site 114615005609 methylcobalamin:coenzyme M methyltransferase; Validated; Region: PRK06252 114615005610 Uroporphyrinogen decarboxylase (URO-D) is a dimeric cytosolic enzyme that decarboxylates the four acetate side chains of uroporphyrinogen III (uro-III) to create coproporphyrinogen III, without requiring any prosthetic groups or cofactors. This reaction...; Region: URO-D; cd00717 114615005611 substrate binding site [chemical binding]; other site 114615005612 active site 114615005613 Cache domain; Region: Cache_1; pfam02743 114615005614 PAS domain S-box; Region: sensory_box; TIGR00229 114615005615 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 114615005616 putative active site [active] 114615005617 heme pocket [chemical binding]; other site 114615005618 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 114615005619 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 114615005620 metal binding site [ion binding]; metal-binding site 114615005621 active site 114615005622 I-site; other site 114615005623 SlyX; Region: SlyX; pfam04102 114615005624 rhodanese superfamily protein; Provisional; Region: PRK05320 114615005625 Member of the Rhodanese Homology Domain superfamily. This CD includes Escherichia coli YceA, Bacillus subtilis YbfQ, and similar uncharacterized proteins; Region: RHOD_YceA; cd01518 114615005626 active site residue [active] 114615005627 Gamma-glutamyltransferase [Amino acid transport and metabolism]; Region: Ggt; COG0405 114615005628 Gamma-glutamyltranspeptidase; Region: G_glu_transpept; pfam01019 114615005629 FKBP-type peptidyl-prolyl cis-trans isomerases 1 [Posttranslational modification, protein turnover, chaperones]; Region: FkpA; COG0545 114615005630 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 114615005631 CsbD-like; Region: CsbD; pfam05532 114615005632 Cupin domain; Region: Cupin_2; cl17218 114615005633 Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; Region: MATE_like_3; cd13148 114615005634 Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534 114615005635 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; cl17364 114615005636 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 114615005637 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 114615005638 dimer interface [polypeptide binding]; other site 114615005639 phosphorylation site [posttranslational modification] 114615005640 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 114615005641 ATP binding site [chemical binding]; other site 114615005642 Mg2+ binding site [ion binding]; other site 114615005643 G-X-G motif; other site 114615005644 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 114615005645 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 114615005646 active site 114615005647 phosphorylation site [posttranslational modification] 114615005648 intermolecular recognition site; other site 114615005649 dimerization interface [polypeptide binding]; other site 114615005650 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 114615005651 Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885 114615005652 ligand binding site [chemical binding]; other site 114615005653 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3214 114615005654 Protein of unknown function (DUF1006); Region: DUF1006; pfam06224 114615005655 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 114615005656 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 114615005657 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 114615005658 Protein of unknown function (DUF2809); Region: DUF2809; pfam10990 114615005659 4-hydroxyphenylacetate permease; Region: HpaX; TIGR02332 114615005660 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 114615005661 putative substrate translocation pore; other site 114615005662 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 114615005663 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 114615005664 HlyD family secretion protein; Region: HlyD_3; pfam13437 114615005665 Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841 114615005666 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 114615005667 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 114615005668 Conserved protein/domain typically associated with flavoprotein oxygenases, DIM6/NTAB family [General function prediction only]; Region: COG1853 114615005669 Brown fat-inducible thioesterase (BFIT). Brain acyl-CoA hydrolase (BACH). These enzymes deacylate long-chain fatty acids by hydrolyzing acyl-CoA thioesters to free fatty acids and CoA-SH. Eukaryotic members of this family are expressed in brain, testis; Region: BFIT_BACH; cd03442 114615005670 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 114615005671 DeoR-like helix-turn-helix domain; Region: HTH_DeoR; pfam08220 114615005672 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 114615005673 glycerol-3-phosphate dehydrogenase; Reviewed; Region: glpD; PRK12266 114615005674 ABC-type sugar transport systems, ATPase components [Carbohydrate transport and metabolism]; Region: MalK; COG3839 114615005675 ATP-binding cassette domain of the carbohydrate and solute transporters-like; Region: ABC_Carb_Solutes_like; cd03259 114615005676 Walker A/P-loop; other site 114615005677 ATP binding site [chemical binding]; other site 114615005678 Q-loop/lid; other site 114615005679 ABC transporter signature motif; other site 114615005680 Walker B; other site 114615005681 D-loop; other site 114615005682 H-loop/switch region; other site 114615005683 TOBE domain; Region: TOBE; cl01440 114615005684 ABC-type sugar transport systems, ATPase components [Carbohydrate transport and metabolism]; Region: MalK; COG3839 114615005685 ATP-binding cassette domain of the carbohydrate and solute transporters-like; Region: ABC_Carb_Solutes_like; cd03259 114615005686 Walker A/P-loop; other site 114615005687 ATP binding site [chemical binding]; other site 114615005688 Q-loop/lid; other site 114615005689 ABC transporter signature motif; other site 114615005690 Walker B; other site 114615005691 D-loop; other site 114615005692 H-loop/switch region; other site 114615005693 TOBE domain; Region: TOBE_2; pfam08402 114615005694 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 114615005695 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 114615005696 dimer interface [polypeptide binding]; other site 114615005697 conserved gate region; other site 114615005698 putative PBP binding loops; other site 114615005699 ABC-ATPase subunit interface; other site 114615005700 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 114615005701 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 114615005702 dimer interface [polypeptide binding]; other site 114615005703 conserved gate region; other site 114615005704 putative PBP binding loops; other site 114615005705 ABC-ATPase subunit interface; other site 114615005706 Predicted small integral membrane protein (DUF2160); Region: DUF2160; pfam09928 114615005707 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 114615005708 MotA/TolQ/ExbB proton channel family; Region: MotA_ExbB; cl00568 114615005709 Biopolymer transport protein ExbD/TolR; Region: ExbD; cl00537 114615005710 Biopolymer transport protein [Intracellular trafficking and secretion]; Region: ExbD; COG0848 114615005711 Gram-negative bacterial tonB protein; Region: TonB; cl10048 114615005712 EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to...; Region: EFh; cl17302 114615005713 EF-hand domain pair; Region: EF_hand_5; pfam13499 114615005714 Ca2+ binding site [ion binding]; other site 114615005715 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 114615005716 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 114615005717 active site 114615005718 phosphorylation site [posttranslational modification] 114615005719 intermolecular recognition site; other site 114615005720 dimerization interface [polypeptide binding]; other site 114615005721 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 114615005722 DNA binding residues [nucleotide binding] 114615005723 dimerization interface [polypeptide binding]; other site 114615005724 Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629 114615005725 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 114615005726 NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902 114615005727 Old yellow enzyme (OYE)-like FMN binding domain. OYE was the first flavin-dependent enzyme identified, however its true physiological role remains elusive to this day. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a...; Region: OYE_like_FMN; cd02933 114615005728 FMN binding site [chemical binding]; other site 114615005729 active site 114615005730 substrate binding site [chemical binding]; other site 114615005731 catalytic residue [active] 114615005732 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: RbsB; COG1879 114615005733 Periplasmic sugar-binding component of uncharacterized ABC-type transport systems that are members of the pentose/hexose sugar-binding protein family of the type I periplasmic binding protein superfamily; Region: PBP1_ABC_sugar_binding_like_1; cd06300 114615005734 putative ligand binding site [chemical binding]; other site 114615005735 ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129 114615005736 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 114615005737 Walker A/P-loop; other site 114615005738 ATP binding site [chemical binding]; other site 114615005739 Q-loop/lid; other site 114615005740 ABC transporter signature motif; other site 114615005741 Walker B; other site 114615005742 D-loop; other site 114615005743 H-loop/switch region; other site 114615005744 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 114615005745 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 114615005746 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 114615005747 TM-ABC transporter signature motif; other site 114615005748 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 114615005749 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 114615005750 TM-ABC transporter signature motif; other site 114615005751 Domain of unknown function (DUF1993); Region: DUF1993; pfam09351 114615005752 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 114615005753 NAD dependent epimerase/dehydratase family; Region: Epimerase; pfam01370 114615005754 NAD(P) binding site [chemical binding]; other site 114615005755 active site 114615005756 4-Oxalocrotonate Tautomerase: Catalyzes the isomerization of unsaturated ketones. The structure is a homohexamer that is arranged as a trimer of dimers. The hexamer contains six active sites, each formed by residues from three monomers, two from one...; Region: 4Oxalocrotonate_Tautomerase; cl00235 114615005757 active site 1 [active] 114615005758 dimer interface [polypeptide binding]; other site 114615005759 hexamer interface [polypeptide binding]; other site 114615005760 active site 2 [active] 114615005761 lytic murein transglycosylase; Region: MltB_2; TIGR02283 114615005762 murein hydrolase B; Provisional; Region: PRK10760; cl17906 114615005763 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 114615005764 phosphoglucomutase; Validated; Region: PRK07564 114615005765 This bacterial PGM-like (phosphoglucomutase-like) protein of unknown function belongs to the alpha-D-phosphohexomutase superfamily. The alpha-D-phosphohexomutases include several related enzymes that catalyze a reversible intramolecular phosphoryl...; Region: PGM_like3; cd05801 114615005766 active site 114615005767 substrate binding site [chemical binding]; other site 114615005768 metal binding site [ion binding]; metal-binding site 114615005769 alpha-ketoglutarate decarboxylase; Reviewed; Region: kgd; PRK12270 114615005770 Glutathione-dependent formaldehyde dehydrogenase related proteins, child 1; Region: FDH_like_1; cd08283 114615005771 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 114615005772 NAD binding site [chemical binding]; other site 114615005773 catalytic Zn binding site [ion binding]; other site 114615005774 structural Zn binding site [ion binding]; other site 114615005775 Flp pilus assembly protein TadG [Intracellular trafficking and secretion]; Region: TadG; COG4961 114615005776 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 114615005777 Glucan_BSP_ModH catalyzes the elongation of beta-1,2 polyglucose chains of glucan; Region: Glucan_BSP_ModH; cd04191 114615005778 Ligand binding site; other site 114615005779 DXD motif; other site 114615005780 glucan biosynthesis protein G; Provisional; Region: mdoG; PRK13274 114615005781 glucan biosynthesis protein D; Provisional; Region: mdoD; PRK13273 114615005782 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3666 114615005783 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 114615005784 Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751 114615005785 DNA-binding transcriptional activator GcvA; Provisional; Region: PRK11139 114615005786 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 114615005787 L-2-amino-thiazoline-4-carboxylic acid hydrolase; Region: ATC_hydrolase; pfam14196 114615005788 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 114615005789 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 114615005790 non-specific DNA binding site [nucleotide binding]; other site 114615005791 salt bridge; other site 114615005792 sequence-specific DNA binding site [nucleotide binding]; other site 114615005793 Predicted transcriptional regulator [General function prediction only]; Region: COG3800 114615005794 Domain of unknown function (DUF955); Region: DUF955; pfam06114 114615005795 Predicted transcriptional regulator (DUF2083); Region: DUF2083; pfam09856 114615005796 Predicted phosphohydrolases [General function prediction only]; Region: Icc; COG1409 114615005797 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 114615005798 active site 114615005799 metal binding site [ion binding]; metal-binding site 114615005800 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_21; cd04680 114615005801 nudix motif; other site 114615005802 glycosyltransferase, TIGR04182 family; Region: glyco_TIGR04182 114615005803 DPM_DPG-synthase_like is a member of the Glycosyltransferase 2 superfamily; Region: DPM_DPG-synthase_like; cd04179 114615005804 Ligand binding site; other site 114615005805 Putative Catalytic site; other site 114615005806 DXD motif; other site 114615005807 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 114615005808 M20 Peptidase Aminoacylase 1 subfamily; Region: M20_Acy1_like1; cd05666 114615005809 metal binding site [ion binding]; metal-binding site 114615005810 putative dimer interface [polypeptide binding]; other site 114615005811 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 114615005812 Coenzyme A binding pocket [chemical binding]; other site 114615005813 Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629 114615005814 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 114615005815 Protein of unknown function (DUF1355); Region: DUF1355; cl17712 114615005816 N-terminal double-transmembrane domain; Region: two_anch; TIGR02226 114615005817 A4 beta-galactosidase middle domain: a type 1 glutamine amidotransferase (GATase1)-like domain; Region: A4_beta-galactosidase_middle_domain; cd03143 114615005818 Domain of unknown function (DUF4159); Region: DUF4159; pfam13709 114615005819 Uncharacterized conserved protein (some members contain a von Willebrand factor type A (vWA) domain) [General function prediction only]; Region: COG1721 114615005820 Protein of unknown function DUF58; Region: DUF58; pfam01882 114615005821 MoxR-like ATPases [General function prediction only]; Region: COG0714 114615005822 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 114615005823 Walker A motif; other site 114615005824 ATP binding site [chemical binding]; other site 114615005825 Walker B motif; other site 114615005826 arginine finger; other site 114615005827 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3816 114615005828 Protein of unknown function (DUF1285); Region: DUF1285; pfam06938 114615005829 Coenzyme A pyrophosphatase (CoAse), a member of the Nudix hydrolase superfamily, functions to catalyze the elimination of oxidized inactive CoA, which can inhibit CoA-utilizing enzymes. The need of CoAses mainly arises under conditions of oxidative...; Region: CoAse; cd03426 114615005830 putative active site [active] 114615005831 putative CoA binding site [chemical binding]; other site 114615005832 nudix motif; other site 114615005833 metal binding site [ion binding]; metal-binding site 114615005834 tRNA nucleotidyltransferase/poly(A) polymerase [Translation, ribosomal structure and biogenesis]; Region: PcnB; COG0617 114615005835 Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398 114615005836 active site 114615005837 NTP binding site [chemical binding]; other site 114615005838 metal binding triad [ion binding]; metal-binding site 114615005839 Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627 114615005840 Four helix bundle sensory module for signal transduction; Region: 4HB_MCP_1; pfam12729 114615005841 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 114615005842 dimerization interface [polypeptide binding]; other site 114615005843 GAF domain; Region: GAF_3; pfam13492 114615005844 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 114615005845 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 114615005846 metal binding site [ion binding]; metal-binding site 114615005847 active site 114615005848 I-site; other site 114615005849 Predicted hydrolase (HAD superfamily) [General function prediction only]; Region: COG1011 114615005850 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 114615005851 motif II; other site 114615005852 coproporphyrinogen III oxidase; Provisional; Region: PRK05330 114615005853 Coproporphyrinogen III oxidase; Region: Coprogen_oxidas; cl17752 114615005854 6-pyruvoyl tetrahydropterin synthase; Region: PTPS; pfam01242 114615005855 active site 114615005856 Organic radical activating enzymes [Posttranslational modification, protein turnover, chaperones]; Region: NrdG; COG0602 114615005857 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 114615005858 FeS/SAM binding site; other site 114615005859 Predicted rRNA methylase (SpoU class) [Translation, ribosomal structure and biogenesis]; Region: CspR; COG0219 114615005860 ubiquinol-cytochrome c reductase, iron-sulfur subunit; Region: Rieske_proteo; TIGR01416 114615005861 Ubiquitinol-cytochrome C reductase Fe-S subunit TAT signal; Region: UCR_Fe-S_N; pfam10399 114615005862 Iron-sulfur protein (ISP) component of the bc(1) complex family, Rieske domain; The Rieske domain is a [2Fe-2S] cluster binding domain involved in electron transfer. The bc(1) complex is a multisubunit enzyme found in many different organisms including...; Region: Rieske_cytochrome_bc1; cd03470 114615005863 [2Fe-2S] cluster binding site [ion binding]; other site 114615005864 Cytochrome b (N-terminus)/b6/petB: Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria; Region: Cytochrome_b_N; cd00284 114615005865 cytochrome b; Provisional; Region: CYTB; MTH00156 114615005866 Qi binding site; other site 114615005867 intrachain domain interface; other site 114615005868 interchain domain interface [polypeptide binding]; other site 114615005869 heme bH binding site [chemical binding]; other site 114615005870 heme bL binding site [chemical binding]; other site 114615005871 Qo binding site; other site 114615005872 Cytochrome b(C-terminus)/b6/petD: Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria; Region: cytochrome_b_C; cd00290 114615005873 interchain domain interface [polypeptide binding]; other site 114615005874 intrachain domain interface; other site 114615005875 Qi binding site; other site 114615005876 Qo binding site; other site 114615005877 Cytochrome C1 family; Region: Cytochrom_C1; pfam02167 114615005878 Ankyrin repeats (many copies); Region: Ank_4; pfam13637 114615005879 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 114615005880 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 114615005881 Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376 114615005882 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 114615005883 Dienelactone hydrolase and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG0412 114615005884 Domain of unknown function (DUF1835); Region: DUF1835; pfam08874 114615005885 Protein of unknown function; Region: DUF3658; pfam12395 114615005886 anthranilate synthase; Provisional; Region: PRK13566 114615005887 Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715 114615005888 chorismate binding enzyme; Region: Chorismate_bind; pfam00425 114615005889 Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743 114615005890 glutamine binding [chemical binding]; other site 114615005891 catalytic triad [active] 114615005892 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 114615005893 active site 114615005894 Peptidase family M48; Region: Peptidase_M48; cl12018 114615005895 Uncharacterized conserved protein [Function unknown]; Region: LemA; COG1704 114615005896 Secreted repeat of unknown function; Region: Lipoprotein_15; pfam03640 114615005897 Secreted repeat of unknown function; Region: Lipoprotein_15; pfam03640 114615005898 Mitochondrial small ribosomal subunit Rsm22; Region: Rsm22; cl17847 114615005899 chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168 114615005900 ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278 114615005901 Walker A/P-loop; other site 114615005902 ATP binding site [chemical binding]; other site 114615005903 Q-loop/lid; other site 114615005904 SMC proteins Flexible Hinge Domain; Region: SMC_hinge; pfam06470 114615005905 ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278 114615005906 ABC transporter signature motif; other site 114615005907 Walker B; other site 114615005908 D-loop; other site 114615005909 H-loop/switch region; other site 114615005910 Thioredoxin; Region: Thioredoxin_4; pfam13462 114615005911 DSBA-like thioredoxin domain; Region: DSBA; pfam01323 114615005912 Protein of unknown function (DUF721); Region: DUF721; cl02324 114615005913 Plasmid maintenance system antidote protein [General function prediction only]; Region: VapI; COG3093 114615005914 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 114615005915 non-specific DNA binding site [nucleotide binding]; other site 114615005916 salt bridge; other site 114615005917 sequence-specific DNA binding site [nucleotide binding]; other site 114615005918 A/G-specific DNA glycosylase [DNA replication, recombination, and repair]; Region: MutY; COG1194 114615005919 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 114615005920 minor groove reading motif; other site 114615005921 helix-hairpin-helix signature motif; other site 114615005922 substrate binding pocket [chemical binding]; other site 114615005923 active site 114615005924 iron-sulpphur binding domain in DNA-(apurinic or apyrimidinic site) lyase (subfamily of ENDO3); Region: FES; smart00525 114615005925 DNA glycosylase (MutY in bacteria and hMYH in humans) is responsible for repairing misread A*oxoG residues to C*G by removing the inappropriately paired adenine base from the DNA backbone. It belongs to the Nudix hydrolase superfamily and is important...; Region: DNA_Glycosylase_C; cd03431 114615005926 DNA binding and oxoG recognition site [nucleotide binding] 114615005927 glutathionine S-transferase; Provisional; Region: PRK10542 114615005928 GST_N family, Class Beta subfamily; GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of endogenous and xenobiotic alkylating agents, including carcinogens; Region: GST_N_Beta; cd03057 114615005929 C-terminal domain interface [polypeptide binding]; other site 114615005930 GSH binding site (G-site) [chemical binding]; other site 114615005931 dimer interface [polypeptide binding]; other site 114615005932 C-terminal, alpha helical domain of Class Beta Glutathione S-transferases; Region: GST_C_Beta; cd03188 114615005933 dimer interface [polypeptide binding]; other site 114615005934 N-terminal domain interface [polypeptide binding]; other site 114615005935 substrate binding pocket (H-site) [chemical binding]; other site 114615005936 Heme oxygenase catalyzes the rate limiting step in the degradation of heme to bilirubin, it is essential for recycling of iron from heme. Heme is used as a substrate and cofactor for its own degradation to biliverdin, iron, and carbon monoxide. This...; Region: HemeO; cl17299 114615005937 Bacteriophytochrome (light-regulated signal transduction histidine kinase) [Signal transduction mechanisms]; Region: COG4251 114615005938 GAF domain; Region: GAF; pfam01590 114615005939 Phytochrome region; Region: PHY; pfam00360 114615005940 HWE histidine kinase; Region: HWE_HK; pfam07536 114615005941 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 114615005942 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 114615005943 active site 114615005944 phosphorylation site [posttranslational modification] 114615005945 intermolecular recognition site; other site 114615005946 dimerization interface [polypeptide binding]; other site 114615005947 DNA modification methylase [DNA replication, recombination, and repair]; Region: COG0863 114615005948 DNA methylase; Region: N6_N4_Mtase; pfam01555 114615005949 Predicted metalloprotease [General function prediction only]; Region: COG2321 114615005950 Putative neutral zinc metallopeptidase; Region: Zn_peptidase; pfam04228 114615005951 MogA_MoaB family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF) an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea; Region: MogA_MoaB; cd00886 114615005952 MPT binding site; other site 114615005953 trimer interface [polypeptide binding]; other site 114615005954 Transcriptional regulators [Transcription]; Region: MarR; COG1846 114615005955 MarR family; Region: MarR; pfam01047 114615005956 Acetyltransferase (GNAT) domain; Region: Acetyltransf_8; pfam13523 114615005957 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 114615005958 Coenzyme A binding pocket [chemical binding]; other site 114615005959 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 114615005960 active site 114615005961 putative phosphoketolase; Provisional; Region: PRK05261 114615005962 Thiamine pyrophosphate (TPP) family, Phosphoketolase (PK) subfamily, TPP-binding module; PK catalyzes the conversion of D-xylulose 5-phosphate and phosphate to acetyl phosphate, D-glyceraldehyde-3-phosphate and H2O. This enzyme requires divalent...; Region: TPP_PK; cd02011 114615005963 TPP-binding site; other site 114615005964 XFP C-terminal domain; Region: XFP_C; pfam09363 114615005965 DNA repair photolyase [DNA replication, recombination, and repair]; Region: SplB; COG1533 114615005966 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 114615005967 FeS/SAM binding site; other site 114615005968 bacterial Ribonuclease HII-like; Region: RNase_HII_bacteria_HII_like; cd07182 114615005969 RNA/DNA hybrid binding site [nucleotide binding]; other site 114615005970 active site 114615005971 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; pfam13231 114615005972 Family 4 Uracil-DNA glycosylase (UDG), found exclusively in thermophilic organisms; Region: UDG_F4_TTUDGA_like; cd10030 114615005973 Fe-S cluster binding site [ion binding]; other site 114615005974 active site 114615005975 Dehydrogenases (flavoproteins) [Energy production and conversion]; Region: FixC; COG0644 114615005976 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 114615005977 Electron transfer flavoprotein-ubiquinone oxidoreductase; Region: ETF_QO; pfam05187 114615005978 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 114615005979 binding surface 114615005980 TPR motif; other site 114615005981 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 114615005982 binding surface 114615005983 TPR motif; other site 114615005984 TPR repeat; Region: TPR_11; pfam13414 114615005985 TPR repeat; Region: TPR_11; pfam13414 114615005986 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 114615005987 binding surface 114615005988 TPR motif; other site 114615005989 TPR repeat; Region: TPR_11; pfam13414 114615005990 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase; Provisional; Region: PRK14608 114615005991 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 114615005992 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 114615005993 substrate binding pocket [chemical binding]; other site 114615005994 chain length determination region; other site 114615005995 substrate-Mg2+ binding site; other site 114615005996 catalytic residues [active] 114615005997 aspartate-rich region 1; other site 114615005998 active site lid residues [active] 114615005999 aspartate-rich region 2; other site 114615006000 Domain of unknown function (DUF2007); Region: DUF2007; pfam09413 114615006001 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 114615006002 Signal peptide peptidase A (SppA), a serine protease, has catalytic Ser-Lys dyad; Region: S49_Sppa_N_C; cd07023 114615006003 signal peptide peptidase SppA, 36K type; Region: SppA_dom; TIGR00706 114615006004 tandem repeat interface [polypeptide binding]; other site 114615006005 oligomer interface [polypeptide binding]; other site 114615006006 active site residues [active] 114615006007 Class II Glycyl-tRNA synthetase (GlyRS) alpha subunit core catalytic domain. GlyRS functions as a homodimer in eukaryotes, archaea and some bacteria and as a heterotetramer in the remainder of prokaryotes and in arabidopsis. It is responsible for the...; Region: GlyRS_alpha_core; cd00733 114615006008 dimer interface [polypeptide binding]; other site 114615006009 motif 1; other site 114615006010 active site 114615006011 motif 2; other site 114615006012 motif 3; other site 114615006013 Iron-binding zinc finger CDGSH type; Region: zf-CDGSH; pfam09360 114615006014 Iron-binding zinc finger CDGSH type; Region: zf-CDGSH; pfam09360 114615006015 glycyl-tRNA synthetase subunit beta; Validated; Region: glyS; PRK01233 114615006016 Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020 114615006017 Protein of unknown function (DUF1236); Region: DUF1236; pfam06823 114615006018 pyruvate phosphate dikinase; Provisional; Region: PRK09279 114615006019 Pyruvate phosphate dikinase, PEP/pyruvate binding domain; Region: PPDK_N; pfam01326 114615006020 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 114615006021 PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896 114615006022 Cell wall hydrolyses involved in spore germination [Cell envelope biogenesis, outer membrane]; Region: SleB; COG3773 114615006023 Cell Wall Hydrolase; Region: Hydrolase_2; pfam07486 114615006024 L-aspartate oxidase; Provisional; Region: PRK07512 114615006025 L-aspartate oxidase; Provisional; Region: PRK06175 114615006026 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 114615006027 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 114615006028 Major Facilitator Superfamily; Region: MFS_1; pfam07690 114615006029 putative substrate translocation pore; other site 114615006030 Yhdh putative quinone oxidoreductases; Region: MDR_yhdh; cd08288 114615006031 putative quinone oxidoreductase, YhdH/YhfP family; Region: oxido_YhdH; TIGR02823 114615006032 NADP binding site [chemical binding]; other site 114615006033 dimer interface [polypeptide binding]; other site 114615006034 Four helix bundle sensory module for signal transduction; Region: 4HB_MCP_1; pfam12729 114615006035 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 114615006036 dimer interface [polypeptide binding]; other site 114615006037 putative CheW interface [polypeptide binding]; other site 114615006038 Four helix bundle sensory module for signal transduction; Region: 4HB_MCP_1; pfam12729 114615006039 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 114615006040 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 114615006041 dimer interface [polypeptide binding]; other site 114615006042 putative CheW interface [polypeptide binding]; other site 114615006043 Predicted membrane protein (DUF2339); Region: DUF2339; pfam10101 114615006044 Predicted protein tyrosine phosphatase [General function prediction only]; Region: COG5350 114615006045 Predicted hydrolases of HD superfamily [General function prediction only]; Region: COG1896 114615006046 Methyladenine glycosylase; Region: Adenine_glyco; pfam03352 114615006047 Predicted aminomethyltransferase related to GcvT [General function prediction only]; Region: COG0354 114615006048 folate-binding protein YgfZ; Region: ygfZ_signature; TIGR03317 114615006049 Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669 114615006050 dihydroorotase; Validated; Region: PRK09060 114615006051 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 114615006052 Dihydroorotase (DHOase), subgroup IIb; DHOases catalyze the reversible interconversion of carbamoyl aspartate to dihydroorotate, a key reaction in pyrimidine biosynthesis. This group contains the archeal members of the DHOase family; Region: DHOase_IIb; cd01318 114615006053 active site 114615006054 Chemotaxis phosphatase, CheZ; Region: CheZ; cl01219 114615006055 PTS system sorbose-specific iic component; Region: EII-Sor; cl01506 114615006056 Protein of unknown function (DUF2385); Region: DUF2385; pfam09539 114615006057 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_15; cd04673 114615006058 nudix motif; other site 114615006059 Uncharacterized ACR, COG2135; Region: DUF159; pfam02586 114615006060 GDP-mannose pyrophosphatase NudK; Provisional; Region: PRK15009 114615006061 ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424 114615006062 dimer interface [polypeptide binding]; other site 114615006063 ADP-ribose binding site [chemical binding]; other site 114615006064 active site 114615006065 nudix motif; other site 114615006066 metal binding site [ion binding]; metal-binding site 114615006067 putative acetyltransferase; Provisional; Region: PRK03624 114615006068 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 114615006069 Coenzyme A binding pocket [chemical binding]; other site 114615006070 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 114615006071 FAD binding domain; Region: FAD_binding_4; pfam01565 114615006072 Putative translation factor (SUA5) [Translation, ribosomal structure and biogenesis]; Region: SUA5; COG0009 114615006073 Putative GTP-binding controlling metal-binding; Region: SUA5; pfam03481 114615006074 hypothetical protein; Provisional; Region: PRK06126 114615006075 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 114615006076 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 114615006077 HAMP domain; Region: HAMP; pfam00672 114615006078 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 114615006079 dimer interface [polypeptide binding]; other site 114615006080 putative CheW interface [polypeptide binding]; other site 114615006081 Domain of unknown function (DUF4142); Region: DUF4142; pfam13628 114615006082 UDP-glucuronate decarboxylase (UGD) and related proteins, extended (e) SDRs; Region: UGD_SDR_e; cd05230 114615006083 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 114615006084 NAD binding site [chemical binding]; other site 114615006085 putative substrate binding site 2 [chemical binding]; other site 114615006086 putative substrate binding site 1 [chemical binding]; other site 114615006087 active site 114615006088 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4641 114615006089 Glycosyl transferases group 1; Region: Glyco_trans_1_2; pfam13524 114615006090 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4641 114615006091 Glycosyl transferases group 1; Region: Glyco_trans_1_2; pfam13524 114615006092 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4641 114615006093 Glycosyl transferases group 1; Region: Glyco_trans_1_2; pfam13524 114615006094 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 114615006095 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 114615006096 B12-binding domain/radical SAM domain protein, rhizo-twelve system; Region: B12_rSAM_oligo; TIGR04295 114615006097 B12 binding domain; Region: B12-binding; pfam02310 114615006098 B12 binding site [chemical binding]; other site 114615006099 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 114615006100 FeS/SAM binding site; other site 114615006101 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 114615006102 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 114615006103 NAD(P) binding site [chemical binding]; other site 114615006104 active site 114615006105 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 114615006106 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 114615006107 NAD(P) binding site [chemical binding]; other site 114615006108 active site 114615006109 phosphopentomutase; Provisional; Region: PRK05362 114615006110 Metalloenzyme superfamily; Region: Metalloenzyme; pfam01676 114615006111 Beta-xylosidase [Carbohydrate transport and metabolism]; Region: XynB; COG3664 114615006112 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 114615006113 S-adenosylmethionine binding site [chemical binding]; other site 114615006114 NTP_transferases catalyze the transfer of nucleotides onto phosphosugars; Region: NTP_transferase; cd04181 114615006115 active site 114615006116 Substrate binding site; other site 114615006117 Mg++ binding site; other site 114615006118 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 114615006119 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4641 114615006120 Glycosyl transferases group 1; Region: Glyco_trans_1_2; pfam13524 114615006121 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 114615006122 catalytic core [active] 114615006123 Myo-inositol-1-phosphate synthase [Lipid metabolism]; Region: INO1; COG1260 114615006124 Myo-inositol-1-phosphate synthase; Region: NAD_binding_5; cl00554 114615006125 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 114615006126 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 114615006127 Cyclic nucleotide-binding domain; Region: cNMP_binding; pfam00027 114615006128 ligand binding site [chemical binding]; other site 114615006129 Crp-like helix-turn-helix domain; Region: HTH_Crp_2; pfam13545 114615006130 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 114615006131 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 114615006132 Coenzyme A binding pocket [chemical binding]; other site 114615006133 Protein of unknown function (DUF3551); Region: DUF3551; pfam12071 114615006134 Ribonuclease BN family enzyme [Replication, recombination, and repair]; Region: Rbn; COG1295 114615006135 circadian clock protein KaiC; Reviewed; Region: PRK09302 114615006136 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 114615006137 Walker A motif; other site 114615006138 ATP binding site [chemical binding]; other site 114615006139 Walker B motif; other site 114615006140 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 114615006141 Walker A motif; other site 114615006142 ATP binding site [chemical binding]; other site 114615006143 Walker B motif; other site 114615006144 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 114615006145 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 114615006146 dimer interface [polypeptide binding]; other site 114615006147 phosphorylation site [posttranslational modification] 114615006148 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 114615006149 ATP binding site [chemical binding]; other site 114615006150 G-X-G motif; other site 114615006151 Response regulator receiver domain; Region: Response_reg; pfam00072 114615006152 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 114615006153 active site 114615006154 phosphorylation site [posttranslational modification] 114615006155 intermolecular recognition site; other site 114615006156 dimerization interface [polypeptide binding]; other site 114615006157 amidase; Provisional; Region: PRK07487 114615006158 Amidase; Region: Amidase; cl11426 114615006159 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 114615006160 PAS domain; Region: PAS_9; pfam13426 114615006161 putative active site [active] 114615006162 heme pocket [chemical binding]; other site 114615006163 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 114615006164 PAS fold; Region: PAS_3; pfam08447 114615006165 putative active site [active] 114615006166 heme pocket [chemical binding]; other site 114615006167 PAS fold; Region: PAS_3; pfam08447 114615006168 Motif C-terminal to PAS motifs (likely to contribute to PAS structural domain); Region: PAC; smart00086 114615006169 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 114615006170 dimer interface [polypeptide binding]; other site 114615006171 phosphorylation site [posttranslational modification] 114615006172 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 114615006173 ATP binding site [chemical binding]; other site 114615006174 Mg2+ binding site [ion binding]; other site 114615006175 G-X-G motif; other site 114615006176 DoxX; Region: DoxX; pfam07681 114615006177 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4312 114615006178 Serine acetyltransferase, N-terminal; Region: SATase_N; cl05762 114615006179 serine O-acetyltransferase; Region: cysE; TIGR01172 114615006180 Serine acetyltransferase (SAT): SAT catalyzes the CoA-dependent acetylation of the side chain hydroxyl group of L-serine to form O-acetylserine, as the first step of a two-step biosynthetic pathway in bacteria and plants leading to the formation of...; Region: LbH_SAT; cd03354 114615006181 trimer interface [polypeptide binding]; other site 114615006182 active site 114615006183 substrate binding site [chemical binding]; other site 114615006184 CoA binding site [chemical binding]; other site 114615006185 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_24; cd04683 114615006186 nudix motif; other site 114615006187 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 114615006188 classical (c) SDRs; Region: SDR_c; cd05233 114615006189 NAD(P) binding site [chemical binding]; other site 114615006190 active site 114615006191 aldehyde dehydrogenase family 7 member; Region: PLN02315 114615006192 NAD+-dependent alpha-aminoadipic semialdehyde dehydrogenase, ALDH family members 7A1 and 7B; Region: ALDH_F7_AASADH; cd07130 114615006193 tetrameric interface [polypeptide binding]; other site 114615006194 NAD binding site [chemical binding]; other site 114615006195 catalytic residues [active] 114615006196 Protein of unknown function (DUF3606); Region: DUF3606; pfam12244 114615006197 Nicotinamidase/pyrazinamidase (PZase). Nicotinamidase, a ubiquitous enzyme in prokaryotes, converts nicotinamide to nicotinic acid (niacin) and ammonia, which in turn can be recycled to make nicotinamide adenine dinucleotide (NAD). The same enzyme is...; Region: nicotinamidase; cd01011 114615006198 Isochorismatase family; Region: Isochorismatase; pfam00857 114615006199 catalytic triad [active] 114615006200 metal binding site [ion binding]; metal-binding site 114615006201 conserved cis-peptide bond; other site 114615006202 N-methylhydantoinase A/acetone carboxylase, beta subunit [Amino acid transport and metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: HyuA; COG0145 114615006203 Hydantoinase/oxoprolinase N-terminal region; Region: Hydant_A_N; pfam05378 114615006204 Hydantoinase/oxoprolinase; Region: Hydantoinase_A; pfam01968 114615006205 Protein of unknown function (DUF917); Region: DUF917; pfam06032 114615006206 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 114615006207 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 114615006208 Walker A/P-loop; other site 114615006209 ATP binding site [chemical binding]; other site 114615006210 Q-loop/lid; other site 114615006211 ABC transporter signature motif; other site 114615006212 Walker B; other site 114615006213 D-loop; other site 114615006214 H-loop/switch region; other site 114615006215 TOBE domain; Region: TOBE_2; pfam08402 114615006216 Spermidine/putrescine-binding periplasmic protein [Amino acid transport and metabolism]; Region: PotD; COG0687 114615006217 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 114615006218 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 114615006219 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 114615006220 dimer interface [polypeptide binding]; other site 114615006221 conserved gate region; other site 114615006222 putative PBP binding loops; other site 114615006223 ABC-ATPase subunit interface; other site 114615006224 ABC-type Fe3+ transport system, permease component [Inorganic ion transport and metabolism]; Region: ThiP; COG1178 114615006225 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 114615006226 dimer interface [polypeptide binding]; other site 114615006227 conserved gate region; other site 114615006228 putative PBP binding loops; other site 114615006229 ABC-ATPase subunit interface; other site 114615006230 IclR helix-turn-helix domain; Region: HTH_IclR; cl17605 114615006231 Transcriptional regulator [Transcription]; Region: IclR; COG1414 114615006232 Bacterial transcriptional regulator; Region: IclR; pfam01614 114615006233 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 114615006234 Aerobic-type carbon monoxide dehydrogenase, large subunit CoxL/CutL homologs [Energy production and conversion]; Region: CoxL; COG1529 114615006235 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; smart01008 114615006236 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 114615006237 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 114615006238 Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010 114615006239 Cytochrome c; Region: Cytochrom_C; pfam00034 114615006240 Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010 114615006241 Cytochrome C oxidase, cbb3-type, subunit III; Region: Cytochrome_CBB3; pfam13442 114615006242 Aerobic-type carbon monoxide dehydrogenase, small subunit CoxS/CutS homologs [Energy production and conversion]; Region: CoxS; COG2080 114615006243 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 114615006244 catalytic loop [active] 114615006245 iron binding site [ion binding]; other site 114615006246 [2Fe-2S] binding domain; Region: Fer2_2; pfam01799 114615006247 hypothetical protein; Provisional; Region: PRK04334 114615006248 Amino acid synthesis; Region: AA_synth; pfam06684 114615006249 Periplasmic binding protein; Region: Peripla_BP_6; pfam13458 114615006250 Periplasmic solute-binding domain of active transport proteins; Region: PBP1_Arsenic_SBP_like; cd06330 114615006251 putative ligand binding site [chemical binding]; other site 114615006252 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 114615006253 TM-ABC transporter signature motif; other site 114615006254 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 114615006255 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 114615006256 TM-ABC transporter signature motif; other site 114615006257 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411 114615006258 ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219 114615006259 Walker A/P-loop; other site 114615006260 ATP binding site [chemical binding]; other site 114615006261 Q-loop/lid; other site 114615006262 ABC transporter signature motif; other site 114615006263 Walker B; other site 114615006264 D-loop; other site 114615006265 H-loop/switch region; other site 114615006266 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410 114615006267 ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224 114615006268 Walker A/P-loop; other site 114615006269 ATP binding site [chemical binding]; other site 114615006270 Q-loop/lid; other site 114615006271 ABC transporter signature motif; other site 114615006272 Walker B; other site 114615006273 D-loop; other site 114615006274 H-loop/switch region; other site 114615006275 MarR family; Region: MarR_2; pfam12802 114615006276 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 114615006277 Imidazolonepropionase and related amidohydrolases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: HutI; COG1228 114615006278 Amidohydrolase; Region: Amidohydro_5; pfam13594 114615006279 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cd01292 114615006280 active site 114615006281 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 114615006282 Aldose 1-epimerase, similar to Lactococcus lactis lacX; Region: Aldose_epim_lacX; cd09024 114615006283 active site 114615006284 catalytic residues [active] 114615006285 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 114615006286 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 114615006287 active site 114615006288 catalytic tetrad [active] 114615006289 dihydroorotase; Provisional; Region: PRK09237 114615006290 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 114615006291 active site 114615006292 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 114615006293 Aminotransferase class I and II; Region: Aminotran_1_2; pfam00155 114615006294 pyridoxal 5'-phosphate binding site [chemical binding]; other site 114615006295 homodimer interface [polypeptide binding]; other site 114615006296 catalytic residue [active] 114615006297 bifunctional 3,4-dihydroxy-2-butanone 4-phosphate synthase/GTP cyclohydrolase II protein; Provisional; Region: PRK09311 114615006298 3,4-dihydroxy-2-butanone 4-phosphate synthase; Region: DHBP_synthase; pfam00926 114615006299 GTP cyclohydrolase II; Region: GTP_cyclohydro2; pfam00925 114615006300 dimerization interface [polypeptide binding]; other site 114615006301 active site 114615006302 Glutaryl-CoA dehydrogenase; Region: GCD; cd01151 114615006303 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 114615006304 FAD binding site [chemical binding]; other site 114615006305 substrate binding pocket [chemical binding]; other site 114615006306 catalytic base [active] 114615006307 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 114615006308 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 114615006309 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 114615006310 active site 114615006311 metal binding site [ion binding]; metal-binding site 114615006312 Protein of unknown function (DUF1499); Region: DUF1499; pfam07386 114615006313 Periplasmic binding protein; Region: Peripla_BP_6; pfam13458 114615006314 Periplasmic solute-binding domain of active transport proteins that belong to the type I periplasmic binding fold protein family; Region: PBP1_SBP_like_1; cd06327 114615006315 putative ligand binding site [chemical binding]; other site 114615006316 putative acyl-CoA synthetase; Provisional; Region: PRK06018 114615006317 Fatty acyl-CoA synthetases similar to LC-FACS from Thermus thermophiles; Region: ttLC_FACS_AlkK_like; cd12119 114615006318 dimer interface [polypeptide binding]; other site 114615006319 acyl-activating enzyme (AAE) consensus motif; other site 114615006320 putative active site [active] 114615006321 AMP binding site [chemical binding]; other site 114615006322 putative CoA binding site [chemical binding]; other site 114615006323 Extensin-like protein C-terminus; Region: Extensin-like_C; pfam06904 114615006324 Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376 114615006325 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 114615006326 Mg2+ and Co2+ transporters [Inorganic ion transport and metabolism]; Region: CorA; COG0598 114615006327 uncharacterized subgroup of the Escherichia coli Mg2+ transporter CorA_like subfamily; Region: EcCorA-like_u1; cd12837 114615006328 Cl binding site [ion binding]; other site 114615006329 oligomer interface [polypeptide binding]; other site 114615006330 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: FabG; COG1028 114615006331 classical (c) SDRs; Region: SDR_c; cd05233 114615006332 NAD(P) binding site [chemical binding]; other site 114615006333 active site 114615006334 pyridoxamine 5'-phosphate oxidase; Provisional; Region: PRK05679 114615006335 Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_oxidase; pfam01243 114615006336 Pyridoxine 5'-phosphate oxidase C-terminal dimerisation region; Region: PNPOx_C; pfam10590 114615006337 curved DNA-binding protein CbpA; Provisional; Region: PRK10266 114615006338 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 114615006339 HSP70 interaction site [polypeptide binding]; other site 114615006340 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747 114615006341 substrate binding site [polypeptide binding]; other site 114615006342 dimer interface [polypeptide binding]; other site 114615006343 Predicted transmembrane transcriptional regulator (anti-sigma factor) [Transcription]; Region: COG5662 114615006344 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 114615006345 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 114615006346 DNA binding residues [nucleotide binding] 114615006347 enoyl-(acyl carrier protein) reductase; Provisional; Region: PRK08159 114615006348 Enoyl acyl carrier protein (ACP) reductase (ENR), divergent SDR; Region: ENR_SDR; cd05372 114615006349 NAD binding site [chemical binding]; other site 114615006350 homotetramer interface [polypeptide binding]; other site 114615006351 homodimer interface [polypeptide binding]; other site 114615006352 substrate binding site [chemical binding]; other site 114615006353 active site 114615006354 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 114615006355 catalytic core [active] 114615006356 Chorismate synthase [Amino acid transport and metabolism]; Region: AroC; COG0082 114615006357 Chorismase synthase, the enzyme catalyzing the final step of the shikimate pathway; Region: Chorismate_synthase; cd07304 114615006358 Tetramer interface [polypeptide binding]; other site 114615006359 active site 114615006360 FMN-binding site [chemical binding]; other site 114615006361 Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114 114615006362 cyclase homology domain; Region: CHD; cd07302 114615006363 nucleotidyl binding site; other site 114615006364 metal binding site [ion binding]; metal-binding site 114615006365 dimer interface [polypeptide binding]; other site 114615006366 ATP-dependent Clp protease adaptor; Reviewed; Region: clpS; PRK13019 114615006367 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198 114615006368 metal ion-dependent adhesion site (MIDAS); other site 114615006369 Lipoproteins [Cell envelope biogenesis, outer membrane]; Region: RlpA; COG0797 114615006370 Rare lipoprotein A (RlpA)-like double-psi beta-barrel; Region: DPBB_1; pfam03330 114615006371 SAM-dependent methyltransferases related to tRNA (uracil-5-)-methyltransferase [Translation, ribosomal structure and biogenesis]; Region: TrmA; COG2265 114615006372 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 114615006373 S-adenosylmethionine binding site [chemical binding]; other site 114615006374 Predicted rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: COG1189 114615006375 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 114615006376 RNA binding surface [nucleotide binding]; other site 114615006377 FtsJ-like methyltransferase; Region: FtsJ; pfam01728 114615006378 Nucleoside 2-deoxyribosyltransferase; Region: Nuc_deoxyrib_tr; pfam05014 114615006379 1-deoxy-D-xylulose-5-phosphate synthase; Provisional; Region: PRK05444 114615006380 Thiamine pyrophosphate (TPP) family, DXS subfamily, TPP-binding module; 1-Deoxy-D-xylulose-5-phosphate synthase (DXS) is a regulatory enzyme of the mevalonate-independent pathway involved in terpenoid biosynthesis. Terpeniods are plant natural products...; Region: TPP_DXS; cd02007 114615006381 TPP-binding site; other site 114615006382 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 114615006383 PYR/PP interface [polypeptide binding]; other site 114615006384 dimer interface [polypeptide binding]; other site 114615006385 TPP binding site [chemical binding]; other site 114615006386 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 114615006387 exodeoxyribonuclease VII small subunit; Provisional; Region: PRK00977 114615006388 Deacetylases, including yeast histone deacetylase and acetoin utilization protein [Chromatin structure and dynamics / Secondary metabolites biosynthesis, transport, and catabolism]; Region: AcuC; COG0123 114615006389 Histone deacetylases and histone-like deacetylases, classII; Region: HDAC_classII_2; cd11599 114615006390 putative active site [active] 114615006391 Zn binding site [ion binding]; other site 114615006392 5'-nucleotidase/2',3'-cyclic phosphodiesterase and related esterases [Nucleotide transport and metabolism]; Region: UshA; COG0737 114615006393 Bacillus subtilis YhcR endonuclease and related proteins, N-terminal metallophosphatase domain; Region: MPP_YhcR_N; cd07412 114615006394 putative active site [active] 114615006395 putative metal binding site [ion binding]; other site 114615006396 5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872 114615006397 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 114615006398 N-methyltryptophan oxidase; Provisional; Region: solA; PRK11259 114615006399 Superfamily of activating enzymes (E1) of the ubiquitin-like proteins. This family includes classical ubiquitin-activating enzymes E1, ubiquitin-like (ubl) activating enzymes and other mechanistic homologes, like MoeB, Thif1 and others. The common...; Region: E1_enzyme_family; cl17196 114615006400 enoyl-CoA hydratase; Provisional; Region: PRK06688 114615006401 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 114615006402 substrate binding site [chemical binding]; other site 114615006403 oxyanion hole (OAH) forming residues; other site 114615006404 trimer interface [polypeptide binding]; other site 114615006405 Manganese catalase, ferritin-like diiron-binding domain; Region: Mn_catalase; cd01051 114615006406 dimanganese center [ion binding]; other site 114615006407 YciF bacterial stress response protein, ferritin-like iron-binding domain; Region: YciF; cd07909 114615006408 dimerization interface [polypeptide binding]; other site 114615006409 metal binding site [ion binding]; metal-binding site 114615006410 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 114615006411 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 114615006412 active site 114615006413 Acetyl-CoA dehydrogenase C-terminal like; Region: Acyl-CoA_dh_C; pfam12806 114615006414 TIR domain; Region: TIR_2; pfam13676 114615006415 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cl02567 114615006416 FOG: WD40 repeat [General function prediction only]; Region: COG2319 114615006417 GDP-fucose synthetase, extended (e) SDRs; Region: GDP_FS_SDR_e; cd05239 114615006418 GDP-4-keto-6-deoxymannose-3, 5-epimerase-4-reductase; Region: PLN02725 114615006419 NADP binding site [chemical binding]; other site 114615006420 active site 114615006421 putative substrate binding site [chemical binding]; other site 114615006422 GDP-D-mannose dehydratase [Cell envelope biogenesis, outer membrane]; Region: Gmd; COG1089 114615006423 GDP-mannose 4,6 dehydratase, extended (e) SDRs; Region: GDP_MD_SDR_e; cd05260 114615006424 NADP-binding site; other site 114615006425 homotetramer interface [polypeptide binding]; other site 114615006426 substrate binding site [chemical binding]; other site 114615006427 homodimer interface [polypeptide binding]; other site 114615006428 active site 114615006429 Hint domain; Region: Hint_2; pfam13403 114615006430 Hint domain; Region: Hint_2; pfam13403 114615006431 Bacterial transglutaminase-like cysteine proteinase BTLCP; Region: BTLCP; cl17596 114615006432 FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790 114615006433 Sel1-like repeats; Region: SEL1; smart00671 114615006434 Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958 114615006435 Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958 114615006436 pilus (MSHA type) biogenesis protein MshL; Region: pilus_MshL; TIGR02519 114615006437 Bacterial type II and III secretion system protein; Region: Secretin; pfam00263 114615006438 Type II secretory pathway, component PulJ [Intracellular trafficking and secretion]; Region: PulJ; COG4795 114615006439 Type II secretion system (T2SS), protein K; Region: T2SK; pfam03934 114615006440 O-antigen ligase like membrane protein; Region: O-antigen_lig; pfam13425 114615006441 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4627 114615006442 putative glycosyl transferase; Provisional; Region: PRK10307 114615006443 This family is most closely related to the GT1 family of glycosyltransferases. wbuB in E. coli is involved in the biosynthesis of the O26 O-antigen. It has been proposed to function as an N-acetyl-L-fucosamine (L-FucNAc) transferase; Region: GT1_wbuB_like; cd03794 114615006444 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 114615006445 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 114615006446 active site 114615006447 catalytic tetrad [active] 114615006448 Choline dehydrogenase and related flavoproteins [Amino acid transport and metabolism]; Region: BetA; COG2303 114615006449 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 114615006450 Predicted membrane protein involved in D-alanine export [Cell envelope biogenesis, outer membrane]; Region: DltB; COG1696 114615006451 SAM-dependent methyltransferases [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: SmtA; COG0500 114615006452 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 114615006453 S-adenosylmethionine binding site [chemical binding]; other site 114615006454 Predicted carbamoyl transferase, NodU family [Posttranslational modification, protein turnover, chaperones]; Region: COG2192 114615006455 Inactive homolog of metal-dependent proteases, putative molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: COG1214; cl17884 114615006456 Carbamoyltransferase; Region: CmcH_NodU; pfam02543 114615006457 Pectate lyase superfamily protein; Region: Pectate_lyase_3; pfam12708 114615006458 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 114615006459 UDP-glucose LOS-beta-1,4 glucosyltransferase is required for biosynthesis of lipooligosaccharide; Region: Beta4Glucosyltransferase; cd02511 114615006460 putative metal binding site; other site 114615006461 peptidylprolyl isomerase; Provisional; Region: prsA; PRK00059 114615006462 PPIC-type PPIASE domain; Region: Rotamase; pfam00639 114615006463 PBP superfamily domain; Region: PBP_like_2; cl17296 114615006464 filamentous hemagglutinin family N-terminal domain; Region: adhes_NPXG; TIGR01901 114615006465 Filamentous haemagglutinin family outer membrane protein; Region: DUF3739; pfam12545 114615006466 Polysaccharide biosynthesis/export protein; Region: Poly_export; pfam02563 114615006467 polysaccharide export protein EpsE; Region: EpsE; TIGR03028 114615006468 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 114615006469 This family is most closely related to the GT1 family of glycosyltransferases. Bme6 in Brucella melitensis has been shown to be involved in the biosynthesis of a polysaccharide; Region: GT1_Bme6_like; cd03821 114615006470 putative ADP-binding pocket [chemical binding]; other site 114615006471 Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741 114615006472 murein hydrolase B; Provisional; Region: PRK10760; cl17906 114615006473 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 114615006474 N-acetyl-D-glucosamine binding site [chemical binding]; other site 114615006475 catalytic residue [active] 114615006476 DNA-directed RNA polymerase specialized sigma subunit, sigma24 homolog [Transcription]; Region: RpoE; COG1595 114615006477 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 114615006478 Sigma-70, region 4; Region: Sigma70_r4_2; pfam08281 114615006479 DNA binding residues [nucleotide binding] 114615006480 Hemolysin activation/secretion protein [Intracellular trafficking and secretion]; Region: FhaC; COG2831 114615006481 POTRA domain, ShlB-type; Region: POTRA_2; pfam08479 114615006482 Surface antigen; Region: Bac_surface_Ag; pfam01103 114615006483 Domain of unknown function (DUF2341); Region: DUF2341; pfam10102 114615006484 Concanavalin A-like lectin/glucanases superfamily; Region: Laminin_G_3; pfam13385 114615006485 Biopolymer transport proteins [Intracellular trafficking and secretion]; Region: TolQ; COG0811 114615006486 Biopolymer transport protein ExbD/TolR; Region: ExbD; pfam02472 114615006487 Biopolymer transport protein [Intracellular trafficking and secretion]; Region: ExbD; COG0848 114615006488 Gram-negative bacterial tonB protein; Region: TonB; cl10048 114615006489 Protein of unknown function (DUF3450); Region: DUF3450; pfam11932 114615006490 peptidyl-prolyl cis-trans isomerase, EpsD family; Region: cis_trans_EpsD; TIGR02925 114615006491 PPIC-type PPIASE domain; Region: Rotamase; pfam00639 114615006492 Undecaprenyl-phosphate glucose phosphotransferase; Region: WcaJ_sugtrans; TIGR03023 114615006493 Bacterial sugar transferase; Region: Bac_transf; pfam02397 114615006494 Homeodomain-like domain; Region: HTH_23; pfam13384 114615006495 exopolysaccharide transport protein family; Region: eps_transp_fam; TIGR01005 114615006496 Chain length determinant protein; Region: Wzz; pfam02706 114615006497 ArsA ATPase functionas as an efflux pump located on the inner membrane of the cell. This ATP-driven oxyanion pump catalyzes the extrusion of arsenite, antimonite and arsenate. Maintenance of a low intracellular concentration of oxyanion produces...; Region: ArsA; cd02035 114615006498 Nucleotide binding site [chemical binding]; other site 114615006499 Predicted carbamoyl transferase, NodU family [Posttranslational modification, protein turnover, chaperones]; Region: COG2192 114615006500 Carbamoyltransferase; Region: CmcH_NodU; pfam02543 114615006501 SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cd00229 114615006502 active site 114615006503 catalytic triad [active] 114615006504 oxyanion hole [active] 114615006505 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 114615006506 Acetolactate synthase [Amino acid transport and metabolism]; Region: COG3962 114615006507 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 114615006508 TPP binding site [chemical binding]; other site 114615006509 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 114615006510 Thiamine pyrophosphate (TPP) family, IolD subfamily, TPP-binding module; composed of proteins similar to Rhizobium leguminosarum bv. viciae IolD. IolD plays an important role in myo-inositol catabolism; Region: TPP_IolD; cd02003 114615006511 TPP-binding site; other site 114615006512 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 114615006513 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 114615006514 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 114615006515 Integrase core domain; Region: rve_3; pfam13683 114615006516 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 114615006517 FAD binding domain; Region: FAD_binding_4; pfam01565 114615006518 Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247 114615006519 Cysteine-rich domain; Region: CCG; pfam02754 114615006520 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 114615006521 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 114615006522 Multidrug resistance efflux pump [Defense mechanisms]; Region: EmrA; COG1566 114615006523 HlyD family secretion protein; Region: HlyD_3; pfam13437 114615006524 ABC-2 family transporter protein; Region: ABC2_membrane_3; pfam12698 114615006525 ABC-2 family transporter protein; Region: ABC2_membrane_3; pfam12698 114615006526 YhgE/Pip N-terminal domain; Region: pip_yhgE_Nterm; TIGR03061 114615006527 ABC-2 family transporter protein; Region: ABC2_membrane_3; pfam12698 114615006528 efflux pump membrane protein (multidrug resistance protein A); Region: 8a0101; TIGR00998 114615006529 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 114615006530 Arabinose-binding domain of AraC transcription regulator, N-term; Region: Arabinose_bd; pfam12625 114615006531 Helix-turn-helix domain; Region: HTH_18; pfam12833 114615006532 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 114615006533 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 114615006534 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 114615006535 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 114615006536 Peptidase propeptide and YPEB domain; Region: PepSY; pfam03413 114615006537 Cytochrome c; Region: Cytochrom_C; cl11414 114615006538 Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010 114615006539 Cytochrome c; Region: Cytochrom_C; cl11414 114615006540 Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010 114615006541 Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010 114615006542 Cytochrome c; Region: Cytochrom_C; pfam00034 114615006543 Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; pfam00116 114615006544 ba3-like heme-copper oxidase subunit I. The ba3 family of heme-copper oxidases are transmembrane protein complexes in the respiratory chains of prokaryotes and some archaea which catalyze the reduction of O2 and simultaneously pump protons across the...; Region: ba3-like_Oxidase_I; cd01660 114615006545 Putative D-pathway homolog; other site 114615006546 Cytochrome C and Quinol oxidase polypeptide I; Region: COX1; pfam00115 114615006547 Low-spin heme binding site [chemical binding]; other site 114615006548 Subunit I/II interface [polypeptide binding]; other site 114615006549 Putative Q-pathway; other site 114615006550 Putative alternate electron transfer pathway; other site 114615006551 Putative water exit pathway; other site 114615006552 Binuclear center (active site) [active] 114615006553 Putative K-pathway homolog; other site 114615006554 Putative proton exit pathway; other site 114615006555 Subunit I/IIa interface [polypeptide binding]; other site 114615006556 Electron transfer pathway; other site 114615006557 Cytochrome c; Region: Cytochrom_C; cl11414 114615006558 Cytochrome c; Region: Cytochrom_C; cl11414 114615006559 Transcriptional regulator [Transcription]; Region: LysR; COG0583 114615006560 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 114615006561 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 114615006562 dimerization interface [polypeptide binding]; other site 114615006563 Intradiol dioxygenases catalyze the critical ring-cleavage step in the conversion of catecholate derivatives to citric acid cycle intermediates. This family contains catechol 1,2-dioxygenases and protocatechuate 3,4-dioxygenases which are mononuclear...; Region: intradiol_dioxygenase; cl17208 114615006564 chlorocatechol 1,2-dioxygenase; Region: chlorocat_1_2; TIGR02465 114615006565 active site 114615006566 Maleylacetate reductase is involved in many aromatic compounds degradation pathways of aerobic microbes; Region: MAR; cd08177 114615006567 Alcohol dehydrogenase, class IV [Energy production and conversion]; Region: EutG; COG1454 114615006568 active site 114615006569 dimer interface [polypeptide binding]; other site 114615006570 metal binding site [ion binding]; metal-binding site 114615006571 Type I periplasmic ligand-binding domain of uncharacterized ABC (ATPase Binding Cassette)-type active transport systems that are predicted to be involved in transport of amino acids, peptides, or inorganic ions; Region: PBP1_ABC_ligand_binding_like_4; cd06337 114615006572 Periplasmic binding protein; Region: Peripla_BP_6; pfam13458 114615006573 putative ligand binding site [chemical binding]; other site 114615006574 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411 114615006575 ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219 114615006576 Walker A/P-loop; other site 114615006577 ATP binding site [chemical binding]; other site 114615006578 Q-loop/lid; other site 114615006579 ABC transporter signature motif; other site 114615006580 Walker B; other site 114615006581 D-loop; other site 114615006582 H-loop/switch region; other site 114615006583 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410 114615006584 ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224 114615006585 Walker A/P-loop; other site 114615006586 ATP binding site [chemical binding]; other site 114615006587 Q-loop/lid; other site 114615006588 ABC transporter signature motif; other site 114615006589 Walker B; other site 114615006590 D-loop; other site 114615006591 H-loop/switch region; other site 114615006592 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 114615006593 TM-ABC transporter signature motif; other site 114615006594 ABC-type branched-chain amino acid transport system, permease component [Amino acid transport and metabolism]; Region: LivM; COG4177 114615006595 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 114615006596 TM-ABC transporter signature motif; other site 114615006597 FAD binding domain; Region: FAD_binding_3; pfam01494 114615006598 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 114615006599 Hydroxyquinol 1,2-dioxygenase (1,2-HQD) catalyzes the ring cleavage of hydroxyquinol (1,2,4-trihydroxybenzene), a intermediate in the degradation of a large variety of aromatic compounds including some polychloro- and nitroaromatic pollutants, to form...; Region: 1,2-HQD; cd03461 114615006600 dimer interface [polypeptide binding]; other site 114615006601 Protocatechuate 3,4-dioxygenase beta subunit [Secondary metabolites biosynthesis, transport, and catabolism]; Region: PcaH; COG3485 114615006602 active site 114615006603 Transcriptional regulator [Transcription]; Region: LysR; COG0583 114615006604 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 114615006605 The C-terminal substrate binding of LysR-type transcriptional regulator (CbbR) of RubisCO operon, which is involved in the carbon dioxide fixation, contains the type 2 periplasmic binding fold; Region: PBP2_CbbR_RubisCO_like; cd08419 114615006606 putative dimerization interface [polypeptide binding]; other site 114615006607 ribulose bisophosphate carboxylase; Reviewed; Region: rbcL; PRK04208 114615006608 Ribulose bisphosphate carboxylase large chain; Region: RuBisCO_large; cl08232 114615006609 dimer interface [polypeptide binding]; other site 114615006610 catalytic residue [active] 114615006611 metal binding site [ion binding]; metal-binding site 114615006612 Ribulose bisphosphate carboxylase/oxygenase (Rubisco), small subunit. Rubisco is a bifunctional enzyme catalyzes the initial steps of two opposing metabolic pathways: photosynthetic carbon fixation and the competing process of photorespiration. Rubisco...; Region: RuBisCO_small; cd03527 114615006613 multimerization interface [polypeptide binding]; other site 114615006614 Carboxysome shell peptide mid-region; Region: CsoS2_M; pfam12288 114615006615 Carboxysome Shell Carbonic Anhydrase; Region: CsoSCA; cl07510 114615006616 Ethanolamine utilisation protein and carboxysome structural protein domain family; Region: EutN_CcmL; cd01614 114615006617 Hexamer/Pentamer interface [polypeptide binding]; other site 114615006618 central pore; other site 114615006619 Ethanolamine utilisation protein and carboxysome structural protein domain family; Region: EutN_CcmL; cd01614 114615006620 Hexamer/Pentamer interface [polypeptide binding]; other site 114615006621 central pore; other site 114615006622 Carbon dioxide concentrating mechanism/carboxysome shell protein [Secondary metabolites biosynthesis, transport, and catabolism / Energy production and conversion]; Region: CcmK; COG4577 114615006623 Carboxysome Shell 1 (CsoS1); Bacterial Micro-Compartment (BCM) domain; Region: BMC_CsoS1; cd07058 114615006624 Hexamer interface [polypeptide binding]; other site 114615006625 Hexagonal pore residue; other site 114615006626 Hexagonal pore; other site 114615006627 Carboxysome Shell 1 (CsoS1); Bacterial Micro-Compartment (BCM) domain; Region: BMC_CsoS1; cd07058 114615006628 Carbon dioxide concentrating mechanism/carboxysome shell protein [Secondary metabolites biosynthesis, transport, and catabolism / Energy production and conversion]; Region: CcmK; COG4577 114615006629 Hexamer interface [polypeptide binding]; other site 114615006630 Hexagonal pore residue; other site 114615006631 Hexagonal pore; other site 114615006632 PCD_DCoH: The bifunctional protein pterin-4alpha-carbinolamine dehydratase (PCD), also known as DCoH (dimerization cofactor of hepatocyte nuclear factor-1), is both a transcription activator and a metabolic enzyme. DCoH stimulates gene expression by...; Region: PCD_DCoH; cl00942 114615006633 aromatic arch; other site 114615006634 DCoH dimer interaction site [polypeptide binding]; other site 114615006635 DCoH /HNF-1 dimer interaction site [polypeptide binding]; other site 114615006636 DCoH tetramer interaction site [polypeptide binding]; other site 114615006637 substrate binding site [chemical binding]; other site 114615006638 hypothetical protein; Provisional; Region: PRK08999 114615006639 The MutT pyrophosphohydrolase is a prototypical Nudix hydrolase that catalyzes the hydrolysis of nucleoside and deoxynucleoside triphosphates (NTPs and dNTPs) by substitution at a beta-phosphorus to yield a nucleotide monophosphate (NMP) and inorganic...; Region: MutT_pyrophosphohydrolase; cd03425 114615006640 active site 114615006641 8-oxo-dGMP binding site [chemical binding]; other site 114615006642 nudix motif; other site 114615006643 metal binding site [ion binding]; metal-binding site 114615006644 NADH dehydrogenase subunit L; Provisional; Region: PRK08168 114615006645 NADH-Ubiquinone oxidoreductase (complex I), chain 5 N-terminus; Region: Oxidored_q1_N; pfam00662 114615006646 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 114615006647 Uncharacterized protein conserved in bacteria (DUF2309); Region: DUF2309; pfam10070 114615006648 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3002 114615006649 Transcription-repair coupling factor (superfamily II helicase) [DNA replication, recombination, and repair / Transcription]; Region: Mfd; COG1197 114615006650 CarD-like/TRCF domain; Region: CarD_CdnL_TRCF; pfam02559 114615006651 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 114615006652 ATP binding site [chemical binding]; other site 114615006653 putative Mg++ binding site [ion binding]; other site 114615006654 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 114615006655 nucleotide binding region [chemical binding]; other site 114615006656 ATP-binding site [chemical binding]; other site 114615006657 TRCF domain; Region: TRCF; pfam03461 114615006658 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 114615006659 PIN (PilT N terminus) domain: Superfamily; Region: PIN_SF; cl14812 114615006660 CheB methylesterase; Region: CheB_methylest; pfam01339 114615006661 CheB methylesterase; Region: CheB_methylest; pfam01339 114615006662 Methylase of chemotaxis methyl-accepting proteins [Cell motility and secretion / Signal transduction mechanisms]; Region: CheR; COG1352 114615006663 CheR methyltransferase, all-alpha domain; Region: CheR_N; pfam03705 114615006664 CheR methyltransferase, SAM binding domain; Region: CheR; pfam01739 114615006665 PAS domain; Region: PAS_9; pfam13426 114615006666 IncA protein; Region: IncA; pfam04156 114615006667 Leucine-rich repeats of kinetochore protein Cenp-F/LEK1; Region: Cenp-F_leu_zip; pfam10473 114615006668 PAS domain; Region: PAS_10; pfam13596 114615006669 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920 114615006670 HWE histidine kinase; Region: HWE_HK; smart00911 114615006671 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 114615006672 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 114615006673 ligand binding site [chemical binding]; other site 114615006674 flexible hinge region; other site 114615006675 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 114615006676 non-specific DNA interactions [nucleotide binding]; other site 114615006677 DNA binding site [nucleotide binding] 114615006678 sequence specific DNA binding site [nucleotide binding]; other site 114615006679 putative cAMP binding site [chemical binding]; other site 114615006680 Uncharacterized iron-regulated membrane protein [Function unknown]; Region: PiuB; COG3182 114615006681 PepSY-associated TM helix; Region: PepSY_TM_1; pfam13172 114615006682 PepSY-associated TM helix; Region: PepSY_TM_2; pfam13703 114615006683 TonB-dependent siderophore receptor; Region: TonB-siderophor; TIGR01783 114615006684 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 114615006685 N-terminal plug; other site 114615006686 ligand-binding site [chemical binding]; other site 114615006687 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 114615006688 C4-dicarboxylate transporter DctA; Reviewed; Region: PRK01663 114615006689 NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252 114615006690 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 114615006691 Signal transduction histidine kinase regulating C4-dicarboxylate transport system [Signal transduction mechanisms]; Region: COG4191 114615006692 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 114615006693 dimer interface [polypeptide binding]; other site 114615006694 phosphorylation site [posttranslational modification] 114615006695 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 114615006696 ATP binding site [chemical binding]; other site 114615006697 Mg2+ binding site [ion binding]; other site 114615006698 G-X-G motif; other site 114615006699 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204 114615006700 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 114615006701 active site 114615006702 phosphorylation site [posttranslational modification] 114615006703 intermolecular recognition site; other site 114615006704 dimerization interface [polypeptide binding]; other site 114615006705 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 114615006706 Walker A motif; other site 114615006707 ATP binding site [chemical binding]; other site 114615006708 Walker B motif; other site 114615006709 arginine finger; other site 114615006710 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 114615006711 This group of proteins belong to a large family of YjgF/YER057c/UK114-like proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence...; Region: YjgF_YER057c_UK114_like_2; cd06150 114615006712 homotrimer interaction site [polypeptide binding]; other site 114615006713 putative active site [active] 114615006714 ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components [Inorganic ion transport and metabolism]; Region: TauA; COG0715 114615006715 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 114615006716 substrate binding pocket [chemical binding]; other site 114615006717 membrane-bound complex binding site; other site 114615006718 dihydroxy-acid dehydratase; Provisional; Region: PRK00911 114615006719 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 114615006720 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 114615006721 Walker A/P-loop; other site 114615006722 ATP binding site [chemical binding]; other site 114615006723 Q-loop/lid; other site 114615006724 ABC transporter signature motif; other site 114615006725 Walker B; other site 114615006726 D-loop; other site 114615006727 H-loop/switch region; other site 114615006728 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 114615006729 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 114615006730 dimer interface [polypeptide binding]; other site 114615006731 conserved gate region; other site 114615006732 putative PBP binding loops; other site 114615006733 ABC-ATPase subunit interface; other site 114615006734 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 114615006735 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 114615006736 dimer interface [polypeptide binding]; other site 114615006737 conserved gate region; other site 114615006738 putative PBP binding loops; other site 114615006739 ABC-ATPase subunit interface; other site 114615006740 Leucyl aminopeptidase (aminopeptidase T) [Amino acid transport and metabolism]; Region: AmpS; COG2309 114615006741 3-hydroxybutyryl-CoA dehydrogenase; Validated; Region: PRK08269 114615006742 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 114615006743 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 114615006744 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210 114615006745 NAD/NADP octopine/nopaline dehydrogenase, alpha-helical domain; Region: Octopine_DH; pfam02317 114615006746 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 114615006747 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK06187 114615006748 acyl-activating enzyme (AAE) consensus motif; other site 114615006749 AMP binding site [chemical binding]; other site 114615006750 active site 114615006751 CoA binding site [chemical binding]; other site 114615006752 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 114615006753 Acyl-CoA dehydrogenase, N-terminal domain; Region: Acyl-CoA_dh_N; pfam02771 114615006754 Acyl-CoA dehydrogenase; Region: ACAD; cd00567 114615006755 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 114615006756 3-oxoadipate enol-lactonase; Region: protocat_pcaD; TIGR02427 114615006757 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 114615006758 classical (c) SDRs; Region: SDR_c; cd05233 114615006759 NAD(P) binding site [chemical binding]; other site 114615006760 active site 114615006761 Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024 114615006762 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 114615006763 substrate binding site [chemical binding]; other site 114615006764 oxyanion hole (OAH) forming residues; other site 114615006765 trimer interface [polypeptide binding]; other site 114615006766 salicylyl-CoA 5-hydroxylase; Reviewed; Region: PRK08255 114615006767 hypothetical protein; Provisional; Region: PRK07236 114615006768 hypothetical protein; Provisional; Region: PRK07236 114615006769 Old yellow enzyme (OYE) YqjM-like FMN binding domain. YqjM is involved in the oxidative stress response of Bacillus subtilis. Like the other OYE members, each monomer of YqjM contains FMN as a non-covalently bound cofactor and uses NADPH as a reducing...; Region: OYE_YqiM_FMN; cd02932 114615006770 active site 114615006771 FMN binding site [chemical binding]; other site 114615006772 substrate binding site [chemical binding]; other site 114615006773 homotetramer interface [polypeptide binding]; other site 114615006774 catalytic residue [active] 114615006775 hypothetical protein; Provisional; Region: PRK07538 114615006776 hypothetical protein; Provisional; Region: PRK07236 114615006777 Cupin domain; Region: Cupin_2; pfam07883 114615006778 Periplasmic binding protein; Region: Peripla_BP_6; pfam13458 114615006779 Type I periplasmic binding component of active transport systems that are predicted to be involved in 2-nitrobenzoic acid degradation pathway; Region: PBP1_Nba_like; cd06359 114615006780 putative ligand binding site [chemical binding]; other site 114615006781 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 114615006782 MarR family; Region: MarR; pfam01047 114615006783 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 114615006784 Acyl-coenzyme A synthetases/AMP-(fatty) acid ligases [Lipid metabolism]; Region: Acs; COG0365 114615006785 acyl-activating enzyme (AAE) consensus motif; other site 114615006786 AMP binding site [chemical binding]; other site 114615006787 active site 114615006788 CoA binding site [chemical binding]; other site 114615006789 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 114615006790 homotrimer interaction site [polypeptide binding]; other site 114615006791 putative active site [active] 114615006792 Protein of unknown function (DUF1236); Region: DUF1236; pfam06823 114615006793 von Willebrand factor (vWF) type A domain; Region: VWA; smart00327 114615006794 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 114615006795 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 114615006796 Walker A motif; other site 114615006797 ATP binding site [chemical binding]; other site 114615006798 Walker B motif; other site 114615006799 arginine finger; other site 114615006800 TspO/MBR family; Region: TspO_MBR; pfam03073 114615006801 Transcriptional regulator [Transcription]; Region: LysR; COG0583 114615006802 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 114615006803 The C-teminal substrate binding domain of LysR-like nitrogen assimilation control (NAC) protein, contains the type 2 periplasmic binding fold; Region: PBP2_Nac; cd08433 114615006804 putative dimerization interface [polypeptide binding]; other site 114615006805 benzoate transport; Region: 2A0115; TIGR00895 114615006806 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 114615006807 putative substrate translocation pore; other site 114615006808 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 114615006809 Amidohydrolase; Region: Amidohydro_2; pfam04909 114615006810 hypothetical protein; Provisional; Region: PRK09262 114615006811 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084 114615006812 Formate/glycerate dehydrogenases, D-specific 2-hydroxy acid dehydrogenases and related dehydrogenases; Region: FDH_GDH_like; cl17240 114615006813 NAD binding site [chemical binding]; other site 114615006814 Domain of unknown function (DUF1932); Region: DUF1932; pfam09130 114615006815 Predicted metal-dependent hydrolase of the TIM-barrel fold [General function prediction only]; Region: COG3618 114615006816 2-pyrone-4,6-dicarboxylic acid (PDC) hydrolase hydrolyzes PDC to yield 4-oxalomesaconic acid (OMA) or its tautomer, 4-carboxy-2-hydroxymuconic acid (CHM). This reaction is part of the protocatechuate (PCA) 4,5-cleavage pathway. PCA is one of the most...; Region: PDC_hydrolase; cd01311 114615006817 active site 114615006818 The A subunit of Protocatechuate 4,5-dioxygenase (LigAB) is the smaller, non-catalytic subunit; Region: PCA_45_Doxase_A; cd07924 114615006819 tetramer interface [polypeptide binding]; other site 114615006820 dimer interface [polypeptide binding]; other site 114615006821 active site 114615006822 Subunit B of the Class III extradiol dioxygenase, Protocatechuate 4,5-dioxygenase, which catalyzes the oxidization and subsequent ring-opening of protocatechuate; Region: PCA_45_Dioxygenase_B; cd07364 114615006823 Catalytic LigB subunit of aromatic ring-opening dioxygenase; Region: LigB; pfam02900 114615006824 active site 114615006825 Fe(II) binding site [ion binding]; other site 114615006826 dimer interface [polypeptide binding]; other site 114615006827 tetramer interface [polypeptide binding]; other site 114615006828 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 114615006829 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 114615006830 Periplasmic binding protein; Region: Peripla_BP_6; pfam13458 114615006831 Periplasmic binding domain of ATP-binding cassette transporter-like systems that belong to the type I periplasmic binding fold protein superfamily; Region: PBP1_ABC_transporter_LIVBP_like; cd06268 114615006832 ligand binding site [chemical binding]; other site 114615006833 Predicted metal-dependent hydrolase of the TIM-barrel fold [General function prediction only]; Region: COG3618 114615006834 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 114615006835 active site 114615006836 shikimate 5-dehydrogenase; Reviewed; Region: aroE; PRK00258 114615006837 Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501 114615006838 NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065 114615006839 shikimate binding site; other site 114615006840 NAD(P) binding site [chemical binding]; other site 114615006841 AMP nucleosidase; Provisional; Region: PRK08292 114615006842 Bacterial AMP nucleoside phosphorylase N-terminus; Region: AMNp_N; pfam10423 114615006843 Nucleoside phosphorylase [Nucleotide transport and metabolism]; Region: Pfs; COG0775 114615006844 Predicted transcriptional regulators [Transcription]; Region: COG1733 114615006845 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 114615006846 Old yellow enzyme (OYE)-related FMN binding domain, group 5. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a reducing agent with oxygens, quinones, and alpha,beta-unsaturated aldehydes and ketones, and can act as...; Region: OYE_like_5_FMN; cd04747 114615006847 NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902 114615006848 putative active site [active] 114615006849 putative FMN binding site [chemical binding]; other site 114615006850 putative substrate binding site [chemical binding]; other site 114615006851 putative catalytic residue [active] 114615006852 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 114615006853 Cytochrome P450; Region: p450; cl12078 114615006854 4-hydroxyphenylacetate catabolism regulatory protein HpaA; Region: HpaA; TIGR02297 114615006855 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 114615006856 4-hydroxybenzoate 3-monooxygenase; Validated; Region: PRK08243 114615006857 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 114615006858 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 114615006859 Tannase and feruloyl esterase; Region: Tannase; pfam07519 114615006860 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3666 114615006861 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 114615006862 Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751 114615006863 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 114615006864 GAF domain; Region: GAF; pfam01590 114615006865 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 114615006866 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 114615006867 metal binding site [ion binding]; metal-binding site 114615006868 active site 114615006869 I-site; other site 114615006870 PAN domain; Region: PAN_4; pfam14295 114615006871 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 114615006872 DNA binding site [nucleotide binding] 114615006873 Periplasmic sugar-binding domain of uncharacterized transport systems; Region: PBP1_uncharacterized_sugar_binding; cd06307 114615006874 Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407 114615006875 putative ligand binding site [chemical binding]; other site 114615006876 Escherichia coli xylulokinase-like D-xylulose kinases; a subgroup of the FGGY family of carbohydrate kinases; Region: FGGY_D-XK_EcXK-like; cd07808 114615006877 N- and C-terminal domain interface [polypeptide binding]; other site 114615006878 D-xylulose kinase; Region: XylB; TIGR01312 114615006879 active site 114615006880 MgATP binding site [chemical binding]; other site 114615006881 catalytic site [active] 114615006882 metal binding site [ion binding]; metal-binding site 114615006883 xylulose binding site [chemical binding]; other site 114615006884 homodimer interface [polypeptide binding]; other site 114615006885 xylose isomerase; Provisional; Region: PRK05474 114615006886 xylose isomerase; Region: xylose_isom_A; TIGR02630 114615006887 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411 114615006888 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 114615006889 Walker A/P-loop; other site 114615006890 ATP binding site [chemical binding]; other site 114615006891 Q-loop/lid; other site 114615006892 ABC transporter signature motif; other site 114615006893 Walker B; other site 114615006894 D-loop; other site 114615006895 H-loop/switch region; other site 114615006896 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 114615006897 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 114615006898 TM-ABC transporter signature motif; other site 114615006899 Periplasmic sugar-binding domain of active transport systems that are members of the type I periplasmic binding protein (PBP1) superfamily; Region: PBP1_ABC_sugar_binding_like; cd01536 114615006900 Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407 114615006901 ligand binding site [chemical binding]; other site 114615006902 MarR family; Region: MarR_2; pfam12802 114615006903 Transcriptional regulators [Transcription]; Region: MarR; COG1846 114615006904 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 114615006905 Coenzyme A binding pocket [chemical binding]; other site 114615006906 3-hydroxydecanoyl-(acyl carrier protein) dehydratase; Validated; Region: PRK05174 114615006907 active site 2 [active] 114615006908 active site 1 [active] 114615006909 hypothetical protein; Provisional; Region: PRK12472 114615006910 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 114615006911 chromosome segregation protein; Provisional; Region: PRK02224 114615006912 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 114615006913 CoenzymeA binding site [chemical binding]; other site 114615006914 subunit interaction site [polypeptide binding]; other site 114615006915 PHB binding site; other site 114615006916 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 114615006917 CoenzymeA binding site [chemical binding]; other site 114615006918 subunit interaction site [polypeptide binding]; other site 114615006919 PHB binding site; other site 114615006920 Uncharacterized protein conserved in bacteria (DUF2200); Region: DUF2200; pfam09966 114615006921 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 114615006922 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 114615006923 RibD C-terminal domain; Region: RibD_C; cl17279 114615006924 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 114615006925 Flavin containing amine oxidoreductase; Region: Amino_oxidase; pfam01593 114615006926 Type I phosphodiesterase / nucleotide pyrophosphatase; Region: Phosphodiest; pfam01663 114615006927 phosphonoacetate hydrolase; Region: hydr_PhnA; TIGR02335 114615006928 Uncharacterized conserved protein [Function unknown]; Region: COG3379 114615006929 Transcriptional regulator [Transcription]; Region: LysR; COG0583 114615006930 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 114615006931 The C-terminal substrate binding domain of LysR-type transcriptional regulators that involved in the catabolism of nitroaromatic/naphthalene compounds and that of related regulators; contains the type 2 periplasmic binding fold; Region: PBP2_Nitroaromatics_like; cd08417 114615006932 substrate binding pocket [chemical binding]; other site 114615006933 dimerization interface [polypeptide binding]; other site 114615006934 The A subunit of Uncharacterized proteins with similarity to Protocatechuate 4,5-dioxygenase (LigAB); Region: LigA_like_1; cd07925 114615006935 putative dimer interface [polypeptide binding]; other site 114615006936 putative tetramer interface [polypeptide binding]; other site 114615006937 putative active site [active] 114615006938 The B subunit of unknown Class III extradiol dioxygenases with similarity to Protocatechuate 4,5-dioxygenase; Region: PCA_45_Doxase_B_like_1; cd07949 114615006939 Catalytic LigB subunit of aromatic ring-opening dioxygenase; Region: LigB; pfam02900 114615006940 putative active site [active] 114615006941 Fe(II) binding site [ion binding]; other site 114615006942 putative dimer interface [polypeptide binding]; other site 114615006943 putative tetramer interface [polypeptide binding]; other site 114615006944 Domain of Unknown Function with PDB structure (DUF3861); Region: DUF3861; pfam12977 114615006945 Predicted transcriptional regulators [Transcription]; Region: COG1695 114615006946 Transcriptional regulator PadR-like family; Region: PadR; pfam03551 114615006947 multidrug efflux protein; Reviewed; Region: PRK09579 114615006948 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 114615006949 HlyD family secretion protein; Region: HlyD_3; pfam13437 114615006950 efflux transporter, outer membrane factor (OMF) lipoprotein, NodT family; Region: outer_NodT; TIGR01845 114615006951 PepSY-associated TM helix; Region: PepSY_TM_3; pfam13706 114615006952 MarR family; Region: MarR_2; cl17246 114615006953 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 114615006954 Amidohydrolase; Region: Amidohydro_2; pfam04909 114615006955 Bacterial periplasmic substrate-binding proteins; Region: PBPb; smart00062 114615006956 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 114615006957 substrate binding pocket [chemical binding]; other site 114615006958 membrane-bound complex binding site; other site 114615006959 hinge residues; other site 114615006960 C4-dicarboxylate transporter DctA; Reviewed; Region: PRK01663 114615006961 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 114615006962 Predicted metal-dependent hydrolase of the TIM-barrel fold [General function prediction only]; Region: COG3618 114615006963 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 114615006964 active site 114615006965 Uncharacterized protein involved in propionate catabolism [General function prediction only]; Region: PrpD; COG2079 114615006966 acetyl-CoA acetyltransferase; Provisional; Region: PRK06025 114615006967 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 114615006968 dimer interface [polypeptide binding]; other site 114615006969 active site 114615006970 Chloride channel protein EriC [Inorganic ion transport and metabolism]; Region: EriC; COG0038 114615006971 CLC voltage-gated chloride channel. The ClC chloride channels catalyse the selective flow of Cl- ions across cell membranes, thereby regulating electrical excitation in skeletal muscle and the flow of salt and water across epithelial barriers. This...; Region: Voltage_gated_ClC; cd00400 114615006972 Cl- selectivity filter; other site 114615006973 Cl- binding residues [ion binding]; other site 114615006974 pore gating glutamate residue; other site 114615006975 dimer interface [polypeptide binding]; other site 114615006976 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in association with the metalloprotease peptidase M50. CBS is a small domain originally identified in cystathionine beta-synthase and subsequently found in a wide...; Region: CBS_pair_M50_like; cd04801 114615006977 Glucose/sorbosone dehydrogenases [Carbohydrate transport and metabolism]; Region: COG2133 114615006978 cytochrome o ubiquinol oxidase subunit II; Region: CyoA; TIGR01433 114615006979 Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; pfam00116 114615006980 COX Aromatic Rich Motif; Region: COX_ARM; pfam06481 114615006981 Ubiquinol oxidase subunit III subfamily. Ubiquinol oxidase, the terminal oxidase in the respiratory chains of aerobic bacteria, is a multi-chain transmembrane protein located in the cell membrane. It catalyzes the reduction of O2 and simultaneously...; Region: Ubiquinol_oxidase_III; cd02863 114615006982 Subunit I/III interface [polypeptide binding]; other site 114615006983 Subunit III/IV interface [polypeptide binding]; other site 114615006984 cytochrome o ubiquinol oxidase subunit IV; Region: CyoD; TIGR02847 114615006985 Micrococcal nuclease (thermonuclease) homologs [DNA replication, recombination, and repair]; Region: COG1525 114615006986 Staphylococcal nuclease homologues. SNase homologues are found in bacteria, archaea, and eukaryotes. They contain no disufide bonds; Region: SNc; cl00140 114615006987 Catalytic site; other site 114615006988 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 114615006989 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 114615006990 protein binding site [polypeptide binding]; other site 114615006991 Isochorismatase family; Region: Isochorismatase; pfam00857 114615006992 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cd00431 114615006993 catalytic triad [active] 114615006994 conserved cis-peptide bond; other site 114615006995 Xanthine/uracil/vitamin C permease [Nucleotide transport and metabolism]; Region: COG2252 114615006996 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966 114615006997 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 114615006998 catalytic residues [active] 114615006999 DsrE/DsrF-like family; Region: DrsE; cl00672 114615007000 DoxX-like family; Region: DoxX_2; pfam13564 114615007001 Transcriptional regulator [Transcription]; Region: LysR; COG0583 114615007002 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 114615007003 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 114615007004 putative effector binding pocket; other site 114615007005 dimerization interface [polypeptide binding]; other site 114615007006 Cytochrome c [Energy production and conversion]; Region: COG3258 114615007007 Cytochrome c [Energy production and conversion]; Region: COG3258 114615007008 Sulphur oxidation protein SoxZ; Region: SoxZ; pfam08770 114615007009 sulfur oxidation protein SoxY; Provisional; Region: PRK07474 114615007010 Sulfur oxidation protein SoxY; Region: SoxY; pfam13501 114615007011 Cytochrome c; Region: Cytochrom_C; pfam00034 114615007012 Uncharacterized NAD(FAD)-dependent dehydrogenases [General function prediction only]; Region: HcaD; COG0446 114615007013 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 114615007014 Flavocytochrome c sulphide dehydrogenase, flavin-binding; Region: FCSD-flav_bind; pfam09242 114615007015 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 114615007016 Aerobic-type carbon monoxide dehydrogenase, large subunit CoxL/CutL homologs [Energy production and conversion]; Region: CoxL; COG1529 114615007017 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; smart01008 114615007018 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 114615007019 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 114615007020 Aerobic-type carbon monoxide dehydrogenase, small subunit CoxS/CutS homologs [Energy production and conversion]; Region: CoxS; COG2080 114615007021 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 114615007022 catalytic loop [active] 114615007023 iron binding site [ion binding]; other site 114615007024 [2Fe-2S] binding domain; Region: Fer2_2; pfam01799 114615007025 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 114615007026 Major Facilitator Superfamily; Region: MFS_1; pfam07690 114615007027 putative substrate translocation pore; other site 114615007028 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair_10; cd04623 114615007029 Cupin domain; Region: Cupin_2; pfam07883 114615007030 DNA-binding winged-HTH domains [Transcription]; Region: CadC; COG3710 114615007031 DNA binding site [nucleotide binding] 114615007032 Predicted integral membrane protein [Function unknown]; Region: COG5616 114615007033 SnoaL-like domain; Region: SnoaL_2; pfam12680 114615007034 Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072 114615007035 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738 114615007036 Transcriptional regulators [Transcription]; Region: GntR; COG1802 114615007037 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 114615007038 DNA-binding site [nucleotide binding]; DNA binding site 114615007039 This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895 114615007040 biotin synthase; Region: bioB; TIGR00433 114615007041 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 114615007042 FeS/SAM binding site; other site 114615007043 Biotin and Thiamin Synthesis associated domain; Region: BATS; smart00876 114615007044 Alkyl sulfatase and related hydrolases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2015 114615007045 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 114615007046 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 114615007047 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 114615007048 metal binding site [ion binding]; metal-binding site 114615007049 active site 114615007050 I-site; other site 114615007051 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 114615007052 This family is most closely related to the GT1 family of glycosyltransferases. aviGT4 in Streptomyces viridochromogenes has been shown to be involved in biosynthesis of oligosaccharide antibiotic avilamycin A. Inactivation of aviGT4 resulted in a mutant...; Region: GT1_AviGT4_like; cd03802 114615007053 putative ADP-binding pocket [chemical binding]; other site 114615007054 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 114615007055 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 114615007056 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 114615007057 Walker A/P-loop; other site 114615007058 ATP binding site [chemical binding]; other site 114615007059 Q-loop/lid; other site 114615007060 ABC transporter signature motif; other site 114615007061 Walker B; other site 114615007062 D-loop; other site 114615007063 H-loop/switch region; other site 114615007064 Glycogen debranching enzyme [Carbohydrate transport and metabolism]; Region: GDB1; COG3408 114615007065 Protein of unknown function, DUF608; Region: DUF608; pfam04685 114615007066 Amylo-alpha-1,6-glucosidase; Region: GDE_C; pfam06202 114615007067 PRC-barrel domain; Region: PRC; pfam05239 114615007068 Major Facilitator Superfamily; Region: MFS_1; pfam07690 114615007069 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 114615007070 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 114615007071 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 114615007072 ligand binding site [chemical binding]; other site 114615007073 flexible hinge region; other site 114615007074 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 114615007075 putative switch regulator; other site 114615007076 non-specific DNA interactions [nucleotide binding]; other site 114615007077 DNA binding site [nucleotide binding] 114615007078 sequence specific DNA binding site [nucleotide binding]; other site 114615007079 putative cAMP binding site [chemical binding]; other site 114615007080 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 114615007081 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 114615007082 active site 114615007083 phosphorylation site [posttranslational modification] 114615007084 intermolecular recognition site; other site 114615007085 dimerization interface [polypeptide binding]; other site 114615007086 response regulator FixJ; Provisional; Region: fixJ; PRK09390 114615007087 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 114615007088 active site 114615007089 phosphorylation site [posttranslational modification] 114615007090 intermolecular recognition site; other site 114615007091 dimerization interface [polypeptide binding]; other site 114615007092 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 114615007093 DNA binding residues [nucleotide binding] 114615007094 dimerization interface [polypeptide binding]; other site 114615007095 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 114615007096 PAS fold; Region: PAS_3; pfam08447 114615007097 putative active site [active] 114615007098 heme pocket [chemical binding]; other site 114615007099 PAS domain S-box; Region: sensory_box; TIGR00229 114615007100 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 114615007101 putative active site [active] 114615007102 heme pocket [chemical binding]; other site 114615007103 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 114615007104 dimer interface [polypeptide binding]; other site 114615007105 phosphorylation site [posttranslational modification] 114615007106 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 114615007107 ATP binding site [chemical binding]; other site 114615007108 Mg2+ binding site [ion binding]; other site 114615007109 G-X-G motif; other site 114615007110 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 114615007111 Ligand Binding Site [chemical binding]; other site 114615007112 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354 114615007113 Cytochrome cbb3 oxidase subunit I. Cytochrome cbb3 oxidase, the terminal oxidase in the respiratory chains of proteobacteria, is a multi-chain transmembrane protein located in the cell membrane. Like other cytochrome oxidases, it catalyzes the reduction...; Region: cbb3_Oxidase_I; cd01661 114615007114 Low-spin heme binding site [chemical binding]; other site 114615007115 Cytochrome C and Quinol oxidase polypeptide I; Region: COX1; pfam00115 114615007116 Putative water exit pathway; other site 114615007117 Binuclear center (active site) [active] 114615007118 Putative proton exit pathway; other site 114615007119 Cbb3-type cytochrome oxidase, cytochrome c subunit [Energy production and conversion]; Region: CcoO; COG2993 114615007120 Cytochrome C oxidase, mono-heme subunit/FixO; Region: FixO; pfam02433 114615007121 Cytochrome cbb oxidase CcoQ. Cytochrome cbb3 oxidase, the terminal oxidase in the respiratory chains of proteobacteria, is a multi-chain transmembrane protein located in the cell membrane. Like other cytochrome oxidases, it catalyzes the reduction of O2...; Region: cbb3_Oxidase_CcoQ; cd01324 114615007122 cytochrome c oxidase, cbb3-type, subunit III; Region: ccoP; TIGR00782 114615007123 Cytochrome c; Region: Cytochrom_C; cl11414 114615007124 Cytochrome C oxidase, cbb3-type, subunit III; Region: Cytochrome_CBB3; pfam13442 114615007125 cytochrome c oxidase accessory protein FixG; Region: ccoG_rdxA_fixG; TIGR02745 114615007126 4Fe-4S binding domain; Region: Fer4_5; pfam12801 114615007127 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 114615007128 Ubp3 associated protein Bre5; Region: Bre5; pfam11614 114615007129 FixH; Region: FixH; pfam05751 114615007130 Predicted integral membrane protein linked to a cation pump [Inorganic ion transport and metabolism]; Region: COG5456 114615007131 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 114615007132 metal-binding site [ion binding] 114615007133 copper-(or silver)-translocating P-type ATPase; Region: ATPase-IB1_Cu; TIGR01511 114615007134 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 114615007135 Soluble P-type ATPase [General function prediction only]; Region: COG4087 114615007136 Cytochrome oxidase maturation protein cbb3-type; Region: CcoS; cl01253 114615007137 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 114615007138 putative substrate translocation pore; other site 114615007139 Uncharacterized conserved protein, contains double-stranded beta-helix domain [Function unknown]; Region: COG1917 114615007140 Peroxiredoxin (PRX)-like 2 family; hypothetical proteins that show sequence similarity to PRXs. Members of this group contain a CXXC motif, similar to TRX. The second cysteine in the motif corresponds to the peroxidatic cysteine of PRX, however, these...; Region: PRX_like2; cd02970 114615007141 putative catalytic residues [active] 114615007142 Transcriptional regulator [Transcription]; Region: LysR; COG0583 114615007143 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 114615007144 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 114615007145 dimerization interface [polypeptide binding]; other site 114615007146 Hypothetical patatin similar to Z1214 protein of Escherichia coli; Region: Pat_hypo_Ecoli_Z1214_like; cd07209 114615007147 Predicted esterase of the alpha-beta hydrolase superfamily [General function prediction only]; Region: RssA; COG1752 114615007148 nucleophile elbow; other site 114615007149 Patatin phospholipase; Region: DUF3734; pfam12536 114615007150 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 114615007151 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 114615007152 dimer interface [polypeptide binding]; other site 114615007153 putative CheW interface [polypeptide binding]; other site 114615007154 glycogen synthase; Provisional; Region: glgA; PRK00654 114615007155 This family is most closely related to the GT1 family of glycosyltransferases. Glycogen synthase catalyzes the formation and elongation of the alpha-1,4-glucose backbone using ADP-glucose, the second and key step of glycogen biosynthesis. This family...; Region: GT1_Glycogen_synthase_DULL1_like; cd03791 114615007156 ADP-binding pocket [chemical binding]; other site 114615007157 homodimer interface [polypeptide binding]; other site 114615007158 putative CoA-transferase; Provisional; Region: PRK11430 114615007159 CoA-transferase family III; Region: CoA_transf_3; pfam02515 114615007160 Zn-dependent alcohol dehydrogenases [General function prediction only]; Region: AdhP; COG1064 114615007161 6-hydroxyhexanoate dehydrogenase; Region: 6_hydroxyhexanoate_dh_like; cd08240 114615007162 putative NAD(P) binding site [chemical binding]; other site 114615007163 catalytic Zn binding site [ion binding]; other site 114615007164 Isocitrate/isopropylmalate dehydrogenase [Amino acid transport and metabolism]; Region: LeuB; COG0473 114615007165 tartrate dehydrogenase; Region: TTC; TIGR02089 114615007166 Xanthine/uracil/vitamin C permease [Nucleotide transport and metabolism]; Region: COG2252 114615007167 Adenine deaminase [Nucleotide transport and metabolism]; Region: AdeC; COG1001 114615007168 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 114615007169 active site 114615007170 Adenine deaminase C-terminal domain; Region: Adenine_deam_C; pfam13382 114615007171 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 114615007172 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 114615007173 enoyl-CoA hydratase; Provisional; Region: PRK06127 114615007174 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 114615007175 substrate binding site [chemical binding]; other site 114615007176 oxyanion hole (OAH) forming residues; other site 114615007177 trimer interface [polypeptide binding]; other site 114615007178 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 114615007179 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 114615007180 non-specific DNA binding site [nucleotide binding]; other site 114615007181 salt bridge; other site 114615007182 sequence-specific DNA binding site [nucleotide binding]; other site 114615007183 Transcriptional regulator [Transcription]; Region: LysR; COG0583 114615007184 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 114615007185 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 114615007186 dimerization interface [polypeptide binding]; other site 114615007187 Cytochrome c biogenesis protein [Posttranslational modification, protein turnover, chaperones]; Region: CcdA; COG0785 114615007188 Cytochrome C biogenesis protein transmembrane region; Region: DsbD; cl15788 114615007189 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920 114615007190 HWE histidine kinase; Region: HWE_HK; pfam07536 114615007191 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 114615007192 Beta-lactamase; Region: Beta-lactamase; pfam00144 114615007193 Intradiol dioxygenases catalyze the critical ring-cleavage step in the conversion of catecholate derivatives to citric acid cycle intermediates. This family contains catechol 1,2-dioxygenases and protocatechuate 3,4-dioxygenases which are mononuclear...; Region: intradiol_dioxygenase; cl17208 114615007194 catechol 1,2-dioxygenase, proteobacterial; Region: catechol_proteo; TIGR02439 114615007195 active site 114615007196 ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components [Inorganic ion transport and metabolism]; Region: TauA; COG0715 114615007197 NMT1-like family; Region: NMT1_2; pfam13379 114615007198 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 114615007199 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 114615007200 putative PBP binding loops; other site 114615007201 dimer interface [polypeptide binding]; other site 114615007202 ABC-ATPase subunit interface; other site 114615007203 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 114615007204 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 114615007205 Walker A/P-loop; other site 114615007206 ATP binding site [chemical binding]; other site 114615007207 Q-loop/lid; other site 114615007208 ABC transporter signature motif; other site 114615007209 Walker B; other site 114615007210 D-loop; other site 114615007211 H-loop/switch region; other site 114615007212 Globins are heme proteins, which bind and transport oxygen. This family summarizes a diverse set of homologous protein domains, including: (1) tetrameric vertebrate hemoglobins, which are the major protein component of erythrocytes and transport oxygen...; Region: globin; cd01040 114615007213 heme-binding site [chemical binding]; other site 114615007214 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_2; pfam07992 114615007215 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 114615007216 Anaerobic dehydrogenases, typically selenocysteine-containing [Energy production and conversion]; Region: BisC; COG0243 114615007217 Nitrate reductases, NapA (Nitrate-R-NapA), NasA, and NarB catalyze the reduction of nitrate to nitrite. Monomeric Nas is located in the cytoplasm and participates in nitrogen assimilation. Dimeric Nap is located in the periplasm and is coupled to quinol...; Region: MopB_Nitrate-R-NapA-like; cd02754 114615007218 [4Fe-4S] binding site [ion binding]; other site 114615007219 molybdopterin cofactor binding site; other site 114615007220 Nitrate reductases, NapA (Nitrate-R-NapA), NasA, and NarB catalyze the reduction of nitrate to nitrite. Monomeric Nas is located in the cytoplasm and participates in nitrogen assimilation. Dimeric Nap is located in the periplasm and is coupled to quinol...; Region: MopB_CT_Nitrate-R-NapA-like; cd02791 114615007221 molybdopterin cofactor binding site; other site 114615007222 BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324 114615007223 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 114615007224 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 114615007225 active site 114615007226 catalytic tetrad [active] 114615007227 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 114615007228 EamA-like transporter family; Region: EamA; pfam00892 114615007229 EamA-like transporter family; Region: EamA; pfam00892 114615007230 Fumarylacetoacetate (FAA) hydrolase family protein [General function prediction only]; Region: COG3970 114615007231 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557 114615007232 TRAP transporter solute receptor, TAXI family; Region: TRAP_TAXI; TIGR02122 114615007233 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 114615007234 CDP-6-deoxy-delta-3,4-glucoseen reductase; Validated; Region: PRK07609 114615007235 catalytic loop [active] 114615007236 iron binding site [ion binding]; other site 114615007237 Iron-sulfur binding ferredoxin reductase (FNR) proteins combine the FAD and NAD(P) binding regions of FNR with an N-terminal Iron-Sulfur binding cluster domain. Ferredoxin-NADP+ (oxido)reductase is an FAD-containing enzyme that catalyzes the reversible...; Region: FNR_N-term_Iron_sulfur_binding; cd06194 114615007238 FAD binding pocket [chemical binding]; other site 114615007239 FAD binding motif [chemical binding]; other site 114615007240 phosphate binding motif [ion binding]; other site 114615007241 beta-alpha-beta structure motif; other site 114615007242 NAD binding pocket [chemical binding]; other site 114615007243 ferredoxin-type protein NapF; Region: napF; TIGR00402 114615007244 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 114615007245 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 114615007246 putative DNA binding site [nucleotide binding]; other site 114615007247 putative Zn2+ binding site [ion binding]; other site 114615007248 AsnC family; Region: AsnC_trans_reg; pfam01037 114615007249 Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cl01629 114615007250 TPP-binding site [chemical binding]; other site 114615007251 PYR/PP interface [polypeptide binding]; other site 114615007252 dimer interface [polypeptide binding]; other site 114615007253 TPP binding site [chemical binding]; other site 114615007254 Transketolase, pyrimidine binding domain; Region: Transket_pyr; smart00861 114615007255 Rhodococcus ruber 6-oxolauric acid dehydrogenase-like; Region: ALDH_CddD_SSP0762; cd07138 114615007256 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 114615007257 NAD binding site [chemical binding]; other site 114615007258 catalytic residues [active] 114615007259 SMP-30/Gluconolaconase/LRE-like region; Region: SGL; pfam08450 114615007260 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 114615007261 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 114615007262 NAD(P) binding site [chemical binding]; other site 114615007263 active site 114615007264 dihydroxy-acid dehydratase; Validated; Region: PRK06131 114615007265 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 114615007266 Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024 114615007267 substrate binding site [chemical binding]; other site 114615007268 oxyanion hole (OAH) forming residues; other site 114615007269 trimer interface [polypeptide binding]; other site 114615007270 phenylpropionate dioxygenase ferredoxin reductase subunit; Provisional; Region: PRK09754 114615007271 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 114615007272 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 114615007273 Ribokinase catalyses the phosphorylation of ribose to ribose-5-phosphate using ATP. This reaction is the first step in the ribose metabolism. It traps ribose within the cell after uptake and also prepares the sugar for use in the synthesis of nucleotides...; Region: ribokinase; cd01174 114615007274 substrate binding site [chemical binding]; other site 114615007275 dimer interface [polypeptide binding]; other site 114615007276 ATP binding site [chemical binding]; other site 114615007277 Ribokinase-like subgroup B. Found in bacteria and plants, this subgroup is part of the ribokinase/pfkB superfamily. Its oligomerization state is unknown at this time; Region: ribokinase_group_B; cd01945 114615007278 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 114615007279 substrate binding site [chemical binding]; other site 114615007280 ATP binding site [chemical binding]; other site 114615007281 Glutamate dehydrogenase/leucine dehydrogenase [Amino acid transport and metabolism]; Region: GdhA; COG0334 114615007282 Glu/Leu/Phe/Val dehydrogenase, dimerisation domain; Region: ELFV_dehydrog_N; pfam02812 114615007283 NAD(P) binding domain of glutamate dehydrogenase, subgroup 1; Region: NAD_bind_1_Glu_DH; cd01076 114615007284 NAD(P) binding site [chemical binding]; other site 114615007285 Glyoxalase-like domain; Region: Glyoxalase_3; pfam13468 114615007286 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 114615007287 active site 114615007288 NADH(P)-binding; Region: NAD_binding_10; pfam13460 114615007289 atypical (a) SDRs, subgroup 5; Region: SDR_a5; cd05243 114615007290 NAD(P) binding site [chemical binding]; other site 114615007291 putative active site [active] 114615007292 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436 114615007293 putative Helix-turn-helix domain of transposase IS66; Region: HTH_Tnp_IS66; pfam13005 114615007294 Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050 114615007295 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 114615007296 Cytochrome P450; Region: p450; cl12078 114615007297 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 114615007298 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 114615007299 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 114615007300 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 114615007301 HlyD family secretion protein; Region: HlyD_3; pfam13437 114615007302 multidrug efflux protein; Reviewed; Region: PRK09579 114615007303 Protein export membrane protein; Region: SecD_SecF; cl14618 114615007304 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 114615007305 N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911 114615007306 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 114615007307 dimer interface [polypeptide binding]; other site 114615007308 conserved gate region; other site 114615007309 putative PBP binding loops; other site 114615007310 ABC-ATPase subunit interface; other site 114615007311 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 114615007312 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 114615007313 dimer interface [polypeptide binding]; other site 114615007314 conserved gate region; other site 114615007315 putative PBP binding loops; other site 114615007316 ABC-ATPase subunit interface; other site 114615007317 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 114615007318 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_5; cd08511 114615007319 Family of unknown function (DUF1028); Region: DUF1028; pfam06267 114615007320 Gamma-glutamyltransferase [Amino acid transport and metabolism]; Region: Ggt; COG0405 114615007321 Gamma-glutamyltranspeptidase; Region: G_glu_transpept; pfam01019 114615007322 dipeptide transporter ATP-binding subunit; Provisional; Region: dppF; PRK11308 114615007323 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 114615007324 Walker A/P-loop; other site 114615007325 ATP binding site [chemical binding]; other site 114615007326 Q-loop/lid; other site 114615007327 ABC transporter signature motif; other site 114615007328 Walker B; other site 114615007329 D-loop; other site 114615007330 H-loop/switch region; other site 114615007331 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 114615007332 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 114615007333 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 114615007334 Walker A/P-loop; other site 114615007335 ATP binding site [chemical binding]; other site 114615007336 Q-loop/lid; other site 114615007337 ABC transporter signature motif; other site 114615007338 Walker B; other site 114615007339 D-loop; other site 114615007340 H-loop/switch region; other site 114615007341 oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727 114615007342 dipeptide transporter; Provisional; Region: PRK10913 114615007343 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 114615007344 dimer interface [polypeptide binding]; other site 114615007345 conserved gate region; other site 114615007346 putative PBP binding loops; other site 114615007347 ABC-ATPase subunit interface; other site 114615007348 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 114615007349 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 114615007350 dimer interface [polypeptide binding]; other site 114615007351 conserved gate region; other site 114615007352 putative PBP binding loops; other site 114615007353 ABC-ATPase subunit interface; other site 114615007354 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 114615007355 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_2; cd08498 114615007356 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 114615007357 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 114615007358 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 114615007359 homoserine O-acetyltransferase; Provisional; Region: metX; cl17114 114615007360 TAP-like protein; Region: Abhydrolase_4; pfam08386 114615007361 Phasin protein; Region: Phasin_2; cl11491 114615007362 PaaX-like protein; Region: PaaX; pfam07848 114615007363 phenylacetic acid degradation operon negative regulatory protein PaaX; Region: PaaX_trns_reg; TIGR02277 114615007364 PaaX-like protein C-terminal domain; Region: PaaX_C; pfam08223 114615007365 phenylacetate-CoA oxygenase subunit PaaA; Provisional; Region: paaA; PRK13778 114615007366 phenylacetate-CoA oxygenase, PaaG subunit; Region: PA_CoA_Oxy1; TIGR02156 114615007367 phenylacetate-CoA oxygenase subunit PaaB; Provisional; Region: paaB; PRK13781 114615007368 Phenylacetic acid catabolic protein; Region: PaaA_PaaC; pfam05138 114615007369 Predicted metal-sulfur cluster biosynthetic enzyme [General function prediction only]; Region: PaaD; COG2151 114615007370 phenylacetate-CoA oxygenase, PaaJ subunit; Region: PA_CoA_Oxy4; TIGR02159 114615007371 phenylacetate-CoA oxygenase/reductase, PaaK subunit; Region: PA_CoA_Oxy5; TIGR02160 114615007372 NAD(P) binding domain of ferredoxin reductase like phenylacetic acid (PA) degradation oxidoreductase. PA oxidoreductases of E. coli hydroxylate PA-CoA in the second step of PA degradation. Members of this group typically fuse a ferredoxin reductase-like...; Region: PA_degradation_oxidoreductase_like; cd06214 114615007373 FAD binding pocket [chemical binding]; other site 114615007374 FAD binding motif [chemical binding]; other site 114615007375 phosphate binding motif [ion binding]; other site 114615007376 beta-alpha-beta structure motif; other site 114615007377 NAD(p) ribose binding residues [chemical binding]; other site 114615007378 NAD binding pocket [chemical binding]; other site 114615007379 NAD(P)-pyrophosphate-nicotinamide binding residues [chemical binding]; other site 114615007380 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 114615007381 catalytic loop [active] 114615007382 iron binding site [ion binding]; other site 114615007383 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 114615007384 phenylacetate-CoA ligase; Region: PA_CoA_ligase; TIGR02155 114615007385 acyl-activating enzyme (AAE) consensus motif; other site 114615007386 AMP binding site [chemical binding]; other site 114615007387 active site 114615007388 CoA binding site [chemical binding]; other site 114615007389 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 114615007390 CoenzymeA binding site [chemical binding]; other site 114615007391 subunit interaction site [polypeptide binding]; other site 114615007392 PHB binding site; other site 114615007393 Sulphur transport; Region: Sulf_transp; pfam04143 114615007394 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 114615007395 Predicted redox protein, regulator of disulfide bond formation [Posttranslational modification, protein turnover, chaperones]; Region: COG1765 114615007396 Sulfite oxidase and related enzymes [General function prediction only]; Region: COG2041 114615007397 bacterial and archael members of the sulfite oxidase (SO) family of molybdopterin binding domains. This molybdopterin cofactor (Moco) binding domain is found in a variety of oxidoreductases, main members of this family are nitrate reductase (NR) and...; Region: arch_bact_SO_family_Moco; cd02109 114615007398 Moco binding site; other site 114615007399 metal coordination site [ion binding]; other site 114615007400 alpha-ketoglutarate transporter; Provisional; Region: PRK10406 114615007401 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 114615007402 putative substrate translocation pore; other site 114615007403 amidase; Provisional; Region: PRK07486 114615007404 Amidase; Region: Amidase; pfam01425 114615007405 short chain dehydrogenase; Provisional; Region: PRK06125 114615007406 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 114615007407 NAD(P) binding site [chemical binding]; other site 114615007408 active site 114615007409 tartrate dehydrogenase; Region: TTC; TIGR02089 114615007410 Isocitrate/isopropylmalate dehydrogenase [Amino acid transport and metabolism]; Region: LeuB; COG0473 114615007411 Phosphoglycerate dehydrogenase and related dehydrogenases [Amino acid transport and metabolism]; Region: SerA; COG0111 114615007412 Formate/glycerate dehydrogenases, D-specific 2-hydroxy acid dehydrogenases and related dehydrogenases; Region: FDH_GDH_like; cl17240 114615007413 NAD binding site [chemical binding]; other site 114615007414 allantoate amidohydrolase; Reviewed; Region: PRK09290 114615007415 M20 Peptidase beta-alanine synthase, an amidohydrolase; Region: M20_bAS; cd03884 114615007416 active site 114615007417 metal binding site [ion binding]; metal-binding site 114615007418 dimer interface [polypeptide binding]; other site 114615007419 Transcriptional regulator [Transcription]; Region: LysR; COG0583 114615007420 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 114615007421 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 114615007422 dimerization interface [polypeptide binding]; other site 114615007423 hypothetical protein; Provisional; Region: PRK05463 114615007424 ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683 114615007425 Type I periplasmic ligand-binding domain of uncharacterized ABC (ATPase Binding Cassette)-type active transport systems that are predicted to be involved in transport of amino acids, peptides, or inorganic ions; Region: PBP1_ABC_ligand_binding_like_6; cd06340 114615007426 putative ligand binding site [chemical binding]; other site 114615007427 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 114615007428 TM-ABC transporter signature motif; other site 114615007429 ABC-type branched-chain amino acid transport system, permease component [Amino acid transport and metabolism]; Region: LivM; COG4177 114615007430 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 114615007431 TM-ABC transporter signature motif; other site 114615007432 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411 114615007433 ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219 114615007434 Walker A/P-loop; other site 114615007435 ATP binding site [chemical binding]; other site 114615007436 Q-loop/lid; other site 114615007437 ABC transporter signature motif; other site 114615007438 Walker B; other site 114615007439 D-loop; other site 114615007440 H-loop/switch region; other site 114615007441 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410 114615007442 ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224 114615007443 Walker A/P-loop; other site 114615007444 ATP binding site [chemical binding]; other site 114615007445 Q-loop/lid; other site 114615007446 ABC transporter signature motif; other site 114615007447 Walker B; other site 114615007448 D-loop; other site 114615007449 H-loop/switch region; other site 114615007450 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 114615007451 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 114615007452 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 114615007453 dimer interface [polypeptide binding]; other site 114615007454 ABC-ATPase subunit interface; other site 114615007455 putative PBP binding loops; other site 114615007456 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 114615007457 putative PBP binding loops; other site 114615007458 ABC-ATPase subunit interface; other site 114615007459 Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416 114615007460 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 114615007461 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 114615007462 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 114615007463 Walker A/P-loop; other site 114615007464 ATP binding site [chemical binding]; other site 114615007465 Q-loop/lid; other site 114615007466 ABC transporter signature motif; other site 114615007467 Walker B; other site 114615007468 D-loop; other site 114615007469 H-loop/switch region; other site 114615007470 TOBE domain; Region: TOBE_2; pfam08402 114615007471 putative aldolase; Validated; Region: PRK08130 114615007472 intersubunit interface [polypeptide binding]; other site 114615007473 active site 114615007474 Zn2+ binding site [ion binding]; other site 114615007475 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084 114615007476 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 114615007477 Hydroxypyruvate isomerase [Carbohydrate transport and metabolism]; Region: Hfi; COG3622 114615007478 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3395 114615007479 HAMP domain; Region: HAMP; pfam00672 114615007480 dimerization interface [polypeptide binding]; other site 114615007481 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 114615007482 dimer interface [polypeptide binding]; other site 114615007483 putative CheW interface [polypeptide binding]; other site 114615007484 HAMP domain; Region: HAMP; pfam00672 114615007485 dimerization interface [polypeptide binding]; other site 114615007486 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 114615007487 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 114615007488 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 114615007489 dimer interface [polypeptide binding]; other site 114615007490 putative CheW interface [polypeptide binding]; other site 114615007491 Four helix bundle sensory module for signal transduction; Region: 4HB_MCP_1; pfam12729 114615007492 Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840 114615007493 HAMP domain; Region: HAMP; pfam00672 114615007494 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 114615007495 dimer interface [polypeptide binding]; other site 114615007496 putative CheW interface [polypeptide binding]; other site 114615007497 Cache is an extracellular domain that is predicted to have a role in small-molecule recognition in a wide range of proteins; Region: Cache_2; smart01049 114615007498 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 114615007499 dimerization interface [polypeptide binding]; other site 114615007500 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 114615007501 dimer interface [polypeptide binding]; other site 114615007502 Methyl-accepting chemotaxis protein (MCP) signalling domain; Region: MCPsignal; pfam00015 114615007503 putative CheW interface [polypeptide binding]; other site 114615007504 Periplasmic binding protein; Region: Peripla_BP_6; pfam13458 114615007505 Type I periplasmic binding domain of uncharacterized extracellular ligand-binding proteins; Region: PBP1_STKc_like; cd06326 114615007506 putative ligand binding site [chemical binding]; other site 114615007507 Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840 114615007508 HAMP domain; Region: HAMP; pfam00672 114615007509 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 114615007510 dimer interface [polypeptide binding]; other site 114615007511 putative CheW interface [polypeptide binding]; other site 114615007512 CHASE3 domain; Region: CHASE3; pfam05227 114615007513 HAMP domain; Region: HAMP; pfam00672 114615007514 dimerization interface [polypeptide binding]; other site 114615007515 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 114615007516 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 114615007517 dimer interface [polypeptide binding]; other site 114615007518 putative CheW interface [polypeptide binding]; other site 114615007519 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 114615007520 PAS fold; Region: PAS_3; pfam08447 114615007521 putative active site [active] 114615007522 heme pocket [chemical binding]; other site 114615007523 HAMP domain; Region: HAMP; pfam00672 114615007524 dimerization interface [polypeptide binding]; other site 114615007525 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 114615007526 Methyl-accepting chemotaxis protein (MCP) signalling domain; Region: MCPsignal; pfam00015 114615007527 dimer interface [polypeptide binding]; other site 114615007528 putative CheW interface [polypeptide binding]; other site 114615007529 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 114615007530 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 114615007531 HSP70 interaction site [polypeptide binding]; other site 114615007532 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 114615007533 binding surface 114615007534 TPR motif; other site 114615007535 TPR repeat; Region: TPR_11; pfam13414 114615007536 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 114615007537 binding surface 114615007538 TPR motif; other site 114615007539 TPR repeat; Region: TPR_11; pfam13414 114615007540 Antibiotic biosynthesis monooxygenase; Region: ABM; pfam03992 114615007541 acetyl-CoA acetyltransferase; Validated; Region: PRK08257 114615007542 Thiolase domain associated with sterol carrier protein (SCP)-x isoform and related proteins; SCP-2 has multiple roles in intracellular lipid circulation and metabolism. The N-terminal presequence in the SCP-x isoform represents a peroxisomal...; Region: SCP-x_thiolase; cd00829 114615007543 active site 114615007544 putative S-transferase; Provisional; Region: PRK11752 114615007545 GST_N family, Ure2p-like subfamily; composed of the Saccharomyces cerevisiae Ure2p and related GSTs. Ure2p is a regulator for nitrogen catabolism in yeast. It represses the expression of several gene products involved in the use of poor nitrogen sources...; Region: GST_N_Ure2p_like; cd03048 114615007546 C-terminal domain interface [polypeptide binding]; other site 114615007547 GSH binding site (G-site) [chemical binding]; other site 114615007548 dimer interface [polypeptide binding]; other site 114615007549 C-terminal, alpha helical domain of Escherichia coli Yghu Glutathione S-transferases and related uncharacterized proteins; Region: GST_C_YghU_like; cd10292 114615007550 dimer interface [polypeptide binding]; other site 114615007551 N-terminal domain interface [polypeptide binding]; other site 114615007552 active site 114615007553 Conserved protein/domain typically associated with flavoprotein oxygenases, DIM6/NTAB family [General function prediction only]; Region: COG1853 114615007554 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 114615007555 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 114615007556 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 114615007557 NAD(P) binding site [chemical binding]; other site 114615007558 active site 114615007559 enoyl-CoA hydratase; Provisional; Region: PRK05981 114615007560 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 114615007561 substrate binding site [chemical binding]; other site 114615007562 oxyanion hole (OAH) forming residues; other site 114615007563 trimer interface [polypeptide binding]; other site 114615007564 Acyl-CoA dehydrogenase (ACAD) 10 and 11, N-terminal domain, and similar proteins. This subfamily is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs); Region: ACAD10_11_like; cd05154 114615007565 Phosphotransferase enzyme family; Region: APH; pfam01636 114615007566 putative active site [active] 114615007567 putative substrate binding site [chemical binding]; other site 114615007568 ATP binding site [chemical binding]; other site 114615007569 enoyl-CoA hydratase; Provisional; Region: PRK06494 114615007570 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 114615007571 substrate binding site [chemical binding]; other site 114615007572 oxyanion hole (OAH) forming residues; other site 114615007573 trimer interface [polypeptide binding]; other site 114615007574 2-enoyl-CoA Hydratase C-terminal region; Region: ECH_C; pfam13766 114615007575 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 114615007576 Acyl-CoA dehydrogenase, N-terminal domain; Region: Acyl-CoA_dh_N; pfam02771 114615007577 Acyl-CoA dehydrogenase; Region: ACAD; cd00567 114615007578 active site 114615007579 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK06187 114615007580 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 114615007581 Bacterial Bile acid CoA ligases and similar proteins; Region: BACL_like; cd05929 114615007582 acyl-activating enzyme (AAE) consensus motif; other site 114615007583 acyl-activating enzyme (AAE) consensus motif; other site 114615007584 putative AMP binding site [chemical binding]; other site 114615007585 putative active site [active] 114615007586 putative CoA binding site [chemical binding]; other site 114615007587 Trans-2-enoyl-CoA reductase (TER) and 2,4-dienoyl-CoA reductase (DECR), atypical (a) SDR; Region: TER_DECR_SDR_a; cd05369 114615007588 short chain dehydrogenase; Provisional; Region: PRK07677 114615007589 NAD(P) binding site [chemical binding]; other site 114615007590 substrate binding site [chemical binding]; other site 114615007591 homotetramer interface [polypeptide binding]; other site 114615007592 active site 114615007593 homodimer interface [polypeptide binding]; other site 114615007594 enoyl-CoA hydratase; Provisional; Region: PRK07509 114615007595 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 114615007596 substrate binding site [chemical binding]; other site 114615007597 oxyanion hole (OAH) forming residues; other site 114615007598 trimer interface [polypeptide binding]; other site 114615007599 long-chain-fatty-acid--CoA ligase; Provisional; Region: PRK12406 114615007600 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 114615007601 Bacterial Bile acid CoA ligases and similar proteins; Region: BACL_like; cd05929 114615007602 acyl-activating enzyme (AAE) consensus motif; other site 114615007603 putative AMP binding site [chemical binding]; other site 114615007604 putative active site [active] 114615007605 putative CoA binding site [chemical binding]; other site 114615007606 phosphoenolpyruvate carboxylase; Reviewed; Region: PRK00009 114615007607 Phosphoenolpyruvate carboxylase [Energy production and conversion]; Region: Ppc; COG2352 114615007608 Gluconolactonase [Carbohydrate transport and metabolism]; Region: COG3386 114615007609 Strictosidine synthase; Region: Str_synth; pfam03088 114615007610 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 114615007611 short chain dehydrogenase; Provisional; Region: PRK07791 114615007612 NAD(P) binding site [chemical binding]; other site 114615007613 active site 114615007614 thiolase; Provisional; Region: PRK06158 114615007615 Thiolase domain associated with sterol carrier protein (SCP)-x isoform and related proteins; SCP-2 has multiple roles in intracellular lipid circulation and metabolism. The N-terminal presequence in the SCP-x isoform represents a peroxisomal...; Region: SCP-x_thiolase; cd00829 114615007616 active site 114615007617 Predicted nucleic-acid-binding protein containing a Zn-ribbon [General function prediction only]; Region: COG1545 114615007618 Rubredoxin-like zinc ribbon domain (DUF35_N); Region: DUF35_N; pfam12172 114615007619 DUF35 OB-fold domain; Region: DUF35; pfam01796 114615007620 amidase; Provisional; Region: PRK07056 114615007621 Amidase; Region: Amidase; cl11426 114615007622 Transglycosylase; Region: Transgly; pfam00912 114615007623 Uncharacterized protein conserved in bacteria (DUF2086); Region: DUF2086; pfam09859 114615007624 alpha-ketoglutarate-dependent dioxygenase AlkB; Provisional; Region: PRK15401 114615007625 hypothetical protein; Provisional; Region: PRK08266 114615007626 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 114615007627 PYR/PP interface [polypeptide binding]; other site 114615007628 dimer interface [polypeptide binding]; other site 114615007629 TPP binding site [chemical binding]; other site 114615007630 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 114615007631 Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cl01629 114615007632 TPP-binding site [chemical binding]; other site 114615007633 2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179 114615007634 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557 114615007635 5-carboxymethyl-2-hydroxymuconate semialdehyde dehydrogenase; Region: HpaE; TIGR02299 114615007636 Human aldehyde dehydrogenase family 8 member A1-like; Region: ALDH_F8_HMSADH; cd07093 114615007637 NAD binding site [chemical binding]; other site 114615007638 catalytic residues [active] 114615007639 5-carboxymethyl-2-hydroxymuconate isomerase (CHMI) is a trimeric enzyme catalyzing the isomerization of the unsaturated ketone 5-(carboxymethyl)-2-hydroxymuconate to 5-(carboxymethyl)-2-oxo-3-hexene-1,6-dionate. This is one step in the...; Region: CHMI; cd00580 114615007640 putative substrate binding pocket [chemical binding]; other site 114615007641 trimer interface [polypeptide binding]; other site 114615007642 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; cl11421 114615007643 homoprotocatechuate degradation operon regulator, HpaR; Region: HpaR; TIGR02337 114615007644 Transcriptional regulators [Transcription]; Region: MarR; COG1846 114615007645 Malate/L-lactate dehydrogenases [Energy production and conversion]; Region: COG2055 114615007646 HpcH/HpaI aldolase/citrate lyase family; Region: HpcH_HpaI; cl17231 114615007647 Domains similar to fish antifreeze type III protein; Region: SAF_AH_GD; cd11613 114615007648 galactarate dehydratase; Region: galactar-dH20; TIGR03248 114615007649 D-galactarate dehydratase / Altronate hydrolase, C terminus; Region: GD_AH_C; pfam04295 114615007650 Bacterial transglutaminase-like N-terminal region; Region: Bact_transglu_N; pfam08379 114615007651 Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305 114615007652 Transglutaminase-like superfamily; Region: Transglut_core; pfam01841 114615007653 Putative amidoligase enzyme (DUF2126); Region: DUF2126; pfam09899 114615007654 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4196 114615007655 A circularly permuted ATPgrasp; Region: CP_ATPgrasp_1; cl17448 114615007656 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2307 114615007657 A predicted alpha-helical domain with a conserved ER motif; Region: Alpha-E; pfam04168 114615007658 Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305 114615007659 Bacterial transglutaminase-like N-terminal region; Region: Bact_transglu_N; pfam08379 114615007660 Transglutaminase-like superfamily; Region: Transglut_core; pfam01841 114615007661 SMP-30/Gluconolaconase/LRE-like region; Region: SGL; pfam08450 114615007662 Glucose/sorbosone dehydrogenases [Carbohydrate transport and metabolism]; Region: COG2133 114615007663 NHAD transporter family protein; Provisional; Region: PLN00137; cl17324 114615007664 Na+/H+ antiporter NhaD and related arsenite permeases [Inorganic ion transport and metabolism]; Region: ArsB; COG1055 114615007665 Uncharacterized protein related to deoxyribodipyrimidine photolyase [General function prediction only]; Region: COG3046 114615007666 Deoxyribodipyrimidine photo-lyase-related protein; Region: DPRP; pfam04244 114615007667 RNA polymerase sigma factor; Provisional; Region: PRK12514 114615007668 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 114615007669 anti-sigma factor, putative, ChrR family; Region: anti_sig_ChrR; TIGR02451 114615007670 Putative zinc-finger; Region: zf-HC2; pfam13490 114615007671 ChrR Cupin-like domain; Region: Cupin_7; pfam12973 114615007672 RNA polymerase sigma factor RpoE; Provisional; Region: PRK09652 114615007673 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 114615007674 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 114615007675 DNA binding residues [nucleotide binding] 114615007676 GTP cyclohydrolase I; Provisional; Region: folE; PRK09347 114615007677 GTP cyclohydrolase I; Provisional; Region: PLN03044 114615007678 active site 114615007679 omega amino acid--pyruvate transaminase; Provisional; Region: PRK13360 114615007680 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 114615007681 inhibitor-cofactor binding pocket; inhibition site 114615007682 pyridoxal 5'-phosphate binding site [chemical binding]; other site 114615007683 catalytic residue [active] 114615007684 Transcriptional regulators [Transcription]; Region: GntR; COG1802 114615007685 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 114615007686 DNA-binding site [nucleotide binding]; DNA binding site 114615007687 Transcriptional regulators [Transcription]; Region: FadR; COG2186 114615007688 This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895 114615007689 Acyl-coenzyme A:6-aminopenicillanic acid acyl-transferase; Region: AAT; pfam03417 114615007690 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 114615007691 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_16; cd08502 114615007692 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 114615007693 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 114615007694 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 114615007695 putative PBP binding loops; other site 114615007696 dimer interface [polypeptide binding]; other site 114615007697 ABC-ATPase subunit interface; other site 114615007698 nickel ABC transporter, permease subunit NikC; Region: nickel_nikC; TIGR02790 114615007699 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 114615007700 dimer interface [polypeptide binding]; other site 114615007701 conserved gate region; other site 114615007702 putative PBP binding loops; other site 114615007703 ABC-ATPase subunit interface; other site 114615007704 ATPase components of various ABC-type transport systems, contain duplicated ATPase [General function prediction only]; Region: COG1123 114615007705 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 114615007706 Walker A/P-loop; other site 114615007707 ATP binding site [chemical binding]; other site 114615007708 Q-loop/lid; other site 114615007709 ABC transporter signature motif; other site 114615007710 Walker B; other site 114615007711 D-loop; other site 114615007712 H-loop/switch region; other site 114615007713 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 114615007714 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 114615007715 Walker A/P-loop; other site 114615007716 ATP binding site [chemical binding]; other site 114615007717 Q-loop/lid; other site 114615007718 ABC transporter signature motif; other site 114615007719 Walker B; other site 114615007720 D-loop; other site 114615007721 H-loop/switch region; other site 114615007722 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 114615007723 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 114615007724 dimerization interface [polypeptide binding]; other site 114615007725 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 114615007726 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 114615007727 dimer interface [polypeptide binding]; other site 114615007728 putative CheW interface [polypeptide binding]; other site 114615007729 B12 binding domain; Region: B12-binding; pfam02310 114615007730 B12 binding site [chemical binding]; other site 114615007731 Elongator protein 3, MiaB family, Radical SAM; Region: Elp3; smart00729 114615007732 Domain of unknown function (DUF4070); Region: DUF4070; pfam13282 114615007733 Predicted exporters of the RND superfamily [General function prediction only]; Region: COG1033 114615007734 Trans-Isoprenyl Diphosphate Synthases, head-to-head; Region: Trans_IPPS_HH; cd00683 114615007735 active site lid residues [active] 114615007736 substrate binding pocket [chemical binding]; other site 114615007737 catalytic residues [active] 114615007738 substrate-Mg2+ binding site; other site 114615007739 aspartate-rich region 1; other site 114615007740 aspartate-rich region 2; other site 114615007741 Trans-Isoprenyl Diphosphate Synthases, head-to-head; Region: Trans_IPPS_HH; cd00683 114615007742 active site lid residues [active] 114615007743 substrate binding pocket [chemical binding]; other site 114615007744 catalytic residues [active] 114615007745 substrate-Mg2+ binding site; other site 114615007746 aspartate-rich region 1; other site 114615007747 aspartate-rich region 2; other site 114615007748 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 114615007749 squalene-associated FAD-dependent desaturase; Region: HpnE; TIGR03467 114615007750 hypothetical protein; Provisional; Region: PRK07077 114615007751 hopanoid biosynthesis associated radical SAM protein HpnH; Region: HpnH; TIGR03470 114615007752 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 114615007753 FeS/SAM binding site; other site 114615007754 Domain of unknown function (DUF3463); Region: DUF3463; pfam11946 114615007755 4-hydroxy-3-methylbut-2-enyl diphosphate reductase; Reviewed; Region: ispH; PRK01045 114615007756 4-Hydroxy-3-methylbut-2-enyl diphosphate reductase IspH [Lipid metabolism]; Region: lytB; COG0761 114615007757 hopanoid biosynthesis associated RND transporter like protein HpnN; Region: HpnN; TIGR03480 114615007758 Uncharacterized protein conserved in bacteria (DUF2147); Region: DUF2147; pfam09917 114615007759 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 114615007760 Ornithine/acetylornithine aminotransferase [Amino acid transport and metabolism]; Region: ArgD; COG4992 114615007761 inhibitor-cofactor binding pocket; inhibition site 114615007762 pyridoxal 5'-phosphate binding site [chemical binding]; other site 114615007763 catalytic residue [active] 114615007764 Predicted transmembrane transcriptional regulator (anti-sigma factor) [Transcription]; Region: COG5662 114615007765 Putative zinc-finger; Region: zf-HC2; pfam13490 114615007766 RNA polymerase sigma factor; Provisional; Region: PRK11924 114615007767 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 114615007768 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 114615007769 DNA binding residues [nucleotide binding] 114615007770 Plastocyanin [Energy production and conversion]; Region: PetE; COG3794 114615007771 Cupredoxin-like domain; Region: Cupredoxin_1; cl17234 114615007772 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 114615007773 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 114615007774 active site 114615007775 metal binding site [ion binding]; metal-binding site 114615007776 glucans biosynthesis protein; Provisional; Region: opgC; PRK03854 114615007777 Acyltransferase family; Region: Acyl_transf_3; pfam01757 114615007778 choline dehydrogenase; Validated; Region: PRK02106 114615007779 lycopene cyclase; Region: lycopene_cycl; TIGR01789 114615007780 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 114615007781 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 114615007782 M20 Peptidase Aminoacylase 1 subfamily; Region: M20_Acy1_like1; cd05666 114615007783 metal binding site [ion binding]; metal-binding site 114615007784 putative dimer interface [polypeptide binding]; other site 114615007785 probable DNA metabolism protein; Region: SAM_7_link_chp; TIGR03915 114615007786 Family 4 Uracil-DNA glycosylase (UDG), found exclusively in thermophilic organisms; Region: UDG_F4_TTUDGA_like; cd10030 114615007787 Fe-S cluster binding site [ion binding]; other site 114615007788 active site 114615007789 putative DNA modification/repair radical SAM protein; Region: rSAM_link_UDG; TIGR03916 114615007790 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 114615007791 FeS/SAM binding site; other site 114615007792 Uncharacterized conserved protein [Function unknown]; Region: COG4544 114615007793 DNA Polymerase Y-family; Region: PolY_like; cd03468 114615007794 active site 114615007795 Nucleotidyltransferase/DNA polymerase involved in DNA repair [DNA replication, recombination, and repair]; Region: DinP; COG0389 114615007796 DNA binding site [nucleotide binding] 114615007797 Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III at DnaE2 gene; Region: PHP_PolIIIA_DnaE2; cd07434 114615007798 putative active site [active] 114615007799 DNA polymerase alpha chain like domain; Region: POLIIIAc; smart00481 114615007800 putative PHP Thumb interface [polypeptide binding]; other site 114615007801 Bacterial DNA polymerase III alpha subunit; Region: DNA_pol3_alpha; pfam07733 114615007802 DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485 114615007803 generic binding surface I; other site 114615007804 generic binding surface II; other site 114615007805 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG1943 114615007806 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 114615007807 Membrane Fusion Protein cluster 2 (function with RND porters); Region: 8a0102; TIGR00999 114615007808 HlyD family secretion protein; Region: HlyD_3; pfam13437 114615007809 Putative silver efflux pump [Inorganic ion transport and metabolism]; Region: COG3696 114615007810 ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224 114615007811 urea ABC transporter, ATP-binding protein UrtE; Region: urea_trans_UrtE; TIGR03410 114615007812 Walker A/P-loop; other site 114615007813 ATP binding site [chemical binding]; other site 114615007814 Q-loop/lid; other site 114615007815 ABC transporter signature motif; other site 114615007816 Walker B; other site 114615007817 D-loop; other site 114615007818 H-loop/switch region; other site 114615007819 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 114615007820 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 114615007821 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 114615007822 TM-ABC transporter signature motif; other site 114615007823 ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219 114615007824 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411 114615007825 Walker A/P-loop; other site 114615007826 ATP binding site [chemical binding]; other site 114615007827 Q-loop/lid; other site 114615007828 ABC transporter signature motif; other site 114615007829 Walker B; other site 114615007830 D-loop; other site 114615007831 H-loop/switch region; other site 114615007832 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 114615007833 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 114615007834 TM-ABC transporter signature motif; other site 114615007835 Periplasmic binding protein; Region: Peripla_BP_6; pfam13458 114615007836 Type I periplasmic-binding protein of the nitrile hydratase (NHase) system that selectively converts nitriles to corresponding amides; Region: PBP1_NHase; cd06358 114615007837 putative ligand binding site [chemical binding]; other site 114615007838 Predicted amidohydrolase [General function prediction only]; Region: COG0388 114615007839 Uncharacterized subgroup of the nitrilase superfamily (putative class 13 nitrilases); Region: nitrilase_2; cd07580 114615007840 putative active site [active] 114615007841 catalytic triad [active] 114615007842 putative dimer interface [polypeptide binding]; other site 114615007843 Response regulator with putative antiterminator output domain [Signal transduction mechanisms]; Region: AmiR; COG3707 114615007844 ANTAR domain; Region: ANTAR; pfam03861 114615007845 Periplasmic binding protein; Region: Peripla_BP_6; pfam13458 114615007846 Periplasmic binding domain of amidase (AmiC) that belongs to the type I periplasmic binding fold protein family; Region: PBP1_AmiC; cd06357 114615007847 ligand binding site [chemical binding]; other site 114615007848 regulator interaction site; other site 114615007849 Domain of unknown function DUF20; Region: UPF0118; pfam01594 114615007850 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 114615007851 Predicted metal-dependent hydrolase of the TIM-barrel fold [General function prediction only]; Region: COG3618 114615007852 2-pyrone-4,6-dicarboxylic acid (PDC) hydrolase hydrolyzes PDC to yield 4-oxalomesaconic acid (OMA) or its tautomer, 4-carboxy-2-hydroxymuconic acid (CHM). This reaction is part of the protocatechuate (PCA) 4,5-cleavage pathway. PCA is one of the most...; Region: PDC_hydrolase; cd01311 114615007853 active site 114615007854 type I secretion outer membrane protein, TolC family; Region: type_I_sec_TolC; TIGR01844 114615007855 enoyl-CoA hydratase; Provisional; Region: PRK05862 114615007856 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 114615007857 substrate binding site [chemical binding]; other site 114615007858 oxyanion hole (OAH) forming residues; other site 114615007859 trimer interface [polypeptide binding]; other site 114615007860 RNA polymerase sigma factor; Provisional; Region: PRK12512 114615007861 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 114615007862 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 114615007863 DNA binding residues [nucleotide binding] 114615007864 Protein of unknown function (DUF1109); Region: DUF1109; pfam06532 114615007865 Uncharacterized protein conserved in bacteria (DUF2336); Region: DUF2336; pfam10098 114615007866 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 114615007867 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 114615007868 metal binding site [ion binding]; metal-binding site 114615007869 active site 114615007870 I-site; other site 114615007871 RNA polymerase sigma factor; Provisional; Region: PRK12515 114615007872 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 114615007873 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 114615007874 DNA binding residues [nucleotide binding] 114615007875 TIGR03809 family protein; Region: TIGR03809 114615007876 twin-arg-translocated uncharacterized repeat protein; Region: RR_plus_rpt_1; TIGR03808 114615007877 putative cofactor-binding repeat; Region: RR_fam_repeat; TIGR03807 114615007878 putative cofactor-binding repeat; Region: RR_fam_repeat; TIGR03807 114615007879 Transglycosylase associated protein; Region: Transgly_assoc; cl00978 114615007880 Pyroglutamyl peptidase (PGP) type I, also known as pyrrolidone carboxyl peptidase (pcp) type I: Enzymes responsible for cleaving pyroglutamate (pGlu) from the N-terminal end of specialized proteins. The N-terminal pGlu protects these proteins from...; Region: Peptidase_C15; cd00501 114615007881 putative substrate binding pocket [chemical binding]; other site 114615007882 AC domain interface; other site 114615007883 catalytic triad [active] 114615007884 AB domain interface; other site 114615007885 interchain disulfide; other site 114615007886 membrane ATPase/protein kinase; Provisional; Region: PRK09435 114615007887 The function of this protein family is unkown. The protein sequences are similar to the ArgK protein in E. coli. ArgK protein is a membrane ATPase which is required for transporting arginine, ornithine and lysine into the cells by the arginine and...; Region: ArgK-like; cd03114 114615007888 Walker A; other site 114615007889 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170 114615007890 G4 box; other site 114615007891 G5 box; other site 114615007892 Protein of unknown function (DUF3298); Region: DUF3298; pfam11738 114615007893 methylmalonyl-CoA mutase; Reviewed; Region: PRK09426 114615007894 Coenzyme B12-dependent-methylmalonyl coenzyme A (CoA) mutase (MCM) family, Alpha subunit-like subfamily; contains proteins similar to the alpha subunit of Propionbacterium shermanni MCM, as well as human and E. coli MCM. Members of this subfamily contain...; Region: MM_CoA_mutase_alpha_like; cd03679 114615007895 active site 114615007896 substrate binding site [chemical binding]; other site 114615007897 coenzyme B12 binding site [chemical binding]; other site 114615007898 methylmalonyl CoA mutase B12 binding domain. This domain binds to B12 (adenosylcobamide), which initiates the conversion of succinyl CoA and methylmalonyl CoA by forming an adenosyl radical, which then undergoes a rearrangement exchanging a hydrogen atom...; Region: MM_CoA_mut_B12_BD; cd02071 114615007899 B12 binding site [chemical binding]; other site 114615007900 cobalt ligand [ion binding]; other site 114615007901 Uncharacterized conserved protein [Function unknown]; Region: COG3791 114615007902 methylmalonyl-CoA mutase, heterodimeric type, beta chain; Region: mmCoA_mut_beta; TIGR00642 114615007903 Coenzyme B12-dependent-methylmalonyl coenzyme A (CoA) mutase (MCM) family, Beta subunit-like subfamily; contains bacterial proteins similar to the beta subunit of MCMs from Propionbacterium shermanni and Streptomyces cinnamonensis, which are alpha/beta...; Region: MM_CoA_mutase_beta; cd03677 114615007904 heterodimer interface [polypeptide binding]; other site 114615007905 substrate interaction site [chemical binding]; other site 114615007906 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase (HPPK). Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and amino acids as well as formyl-tRNA. Mammalian cells are able to utilize pre-formed folates after...; Region: HPPK; cd00483 114615007907 catalytic center binding site [active] 114615007908 ATP binding site [chemical binding]; other site 114615007909 Dihydroneopterin aldolase; Region: FolB; pfam02152 114615007910 active site 114615007911 DHPS subgroup of Pterin binding enzymes. DHPS (dihydropteroate synthase), a functional homodimer, catalyzes the condensation of p-aminobenzoic acid (pABA) in the de novo biosynthesis of folate, which is an essential cofactor in both nucleic acid and...; Region: DHPS; cd00739 114615007912 dihydropteroate synthase; Region: DHPS; TIGR01496 114615007913 substrate binding pocket [chemical binding]; other site 114615007914 dimer interface [polypeptide binding]; other site 114615007915 inhibitor binding site; inhibition site 114615007916 Domain of unknown function (DUF4332); Region: DUF4332; pfam14229 114615007917 Bacterial protein of unknown function (DUF853); Region: DUF853; pfam05872 114615007918 hypothetical protein; Validated; Region: PRK09104 114615007919 Uncharacterized M20 Dipeptidases; Region: M20_dipept_like_3; cd05680 114615007920 metal binding site [ion binding]; metal-binding site 114615007921 putative dimer interface [polypeptide binding]; other site 114615007922 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 114615007923 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 114615007924 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 114615007925 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 114615007926 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 114615007927 Predicted nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG0702 114615007928 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 114615007929 NAD(P) binding site [chemical binding]; other site 114615007930 active site 114615007931 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 114615007932 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 114615007933 metal binding site [ion binding]; metal-binding site 114615007934 active site 114615007935 I-site; other site 114615007936 Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]; Region: DegQ; COG0265 114615007937 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 114615007938 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 114615007939 Chaperonin 10 Kd subunit (cpn10 or GroES); Cpn10 cooperates with chaperonin 60 (cpn60 or GroEL), an ATPase, to assist the folding and assembly of proteins and is found in eubacterial cytosol, as well as in the matrix of mitochondria and chloroplasts. It...; Region: cpn10; cd00320 114615007940 oligomerisation interface [polypeptide binding]; other site 114615007941 mobile loop; other site 114615007942 roof hairpin; other site 114615007943 chaperonin GroEL; Reviewed; Region: groEL; PRK12849 114615007944 GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344 114615007945 ring oligomerisation interface [polypeptide binding]; other site 114615007946 ATP/Mg binding site [chemical binding]; other site 114615007947 stacking interactions; other site 114615007948 hinge regions; other site 114615007949 Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071 114615007950 Alpha-crystallin domain (ACD) found in Escherichia coli inclusion body-associated proteins IbpA and IbpB, and similar proteins. IbpA and IbpB are 16 kDa small heat shock proteins (sHsps). sHsps are molecular chaperones that suppress protein aggregation...; Region: ACD_IbpA-B_like; cd06470 114615007951 putative dimer interface [polypeptide binding]; other site 114615007952 aldolase II superfamily protein; Provisional; Region: PRK07044 114615007953 intersubunit interface [polypeptide binding]; other site 114615007954 active site 114615007955 Zn2+ binding site [ion binding]; other site 114615007956 ROS/MUCR transcriptional regulator protein; Region: ROS_MUCR; pfam05443 114615007957 Cysteine desulfurase SufE subunit [Posttranslational modification, protein turnover, chaperones]; Region: sufE; COG2166 114615007958 PAS domain S-box; Region: sensory_box; TIGR00229 114615007959 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 114615007960 putative active site [active] 114615007961 heme pocket [chemical binding]; other site 114615007962 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 114615007963 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 114615007964 dimer interface [polypeptide binding]; other site 114615007965 phosphorylation site [posttranslational modification] 114615007966 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 114615007967 ATP binding site [chemical binding]; other site 114615007968 Mg2+ binding site [ion binding]; other site 114615007969 G-X-G motif; other site 114615007970 His-Xaa-Ser repeat protein HxsA; Region: His_Ser_Rich; TIGR03979 114615007971 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 114615007972 Protein of unknown function (DUF1491); Region: DUF1491; pfam07372 114615007973 Uncharacterized protein conserved in bacteria (DUF2336); Region: DUF2336; pfam10098 114615007974 succinate CoA transferase; Region: YgfH_subfam; TIGR03458 114615007975 Acetyl-CoA hydrolase/transferase N-terminal domain; Region: AcetylCoA_hydro; pfam02550 114615007976 Acetyl-CoA hydrolase/transferase C-terminal domain; Region: AcetylCoA_hyd_C; pfam13336 114615007977 CYTH-like Clostridium thermocellum TTM-like subgroup 1; Region: CYTH-like_CthTTM-like_1; cd07891 114615007978 putative active site [active] 114615007979 putative metal binding residues [ion binding]; other site 114615007980 signature motif; other site 114615007981 putative dimer interface [polypeptide binding]; other site 114615007982 putative phosphate binding site [ion binding]; other site 114615007983 Predicted integral membrane protein [Function unknown]; Region: COG5436 114615007984 Protein of unknown function (DUF1214); Region: DUF1214; cl08447 114615007985 Transglycosylase; Region: Transgly; pfam00912 114615007986 penicillin-binding protein, 1A family; Region: PBP_1a_fam; TIGR02074 114615007987 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 114615007988 hypothetical protein; Provisional; Region: PRK05170 114615007989 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 114615007990 Major Facilitator Superfamily; Region: MFS_1; pfam07690 114615007991 putative substrate translocation pore; other site 114615007992 Uncharacterized conserved protein [Function unknown]; Region: COG3743 114615007993 Uncharacterized conserved protein [Function unknown]; Region: COG3743 114615007994 Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885 114615007995 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 114615007996 ligand binding site [chemical binding]; other site 114615007997 Predicted exonuclease of the beta-lactamase fold involved in RNA processing [Translation, ribosomal structure and biogenesis]; Region: YSH1; COG1236 114615007998 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 114615007999 Beta-Casp domain; Region: Beta-Casp; smart01027 114615008000 thymidine phosphorylase; Provisional; Region: PRK04350 114615008001 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 114615008002 Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591 114615008003 Pyrimidine nucleoside phosphorylase C-terminal domain; Region: PYNP_C; smart00941 114615008004 Flp/Fap pilin component; Region: Flp_Fap; pfam04964 114615008005 Ku-homolog [Replication, recombination, and repair]; Region: COG1273 114615008006 Ku-core domain, Ku-like subfamily; composed of prokaryotic homologs of the eukaryotic DNA binding protein Ku. The alignment includes the core domain shared by the prokaryotic YkoV-like proteins and the eukaryotic Ku70 and Ku80. The prokaryotic Ku...; Region: KU_like; cd00789 114615008007 putative DNA binding site [nucleotide binding]; other site 114615008008 putative homodimer interface [polypeptide binding]; other site 114615008009 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 114615008010 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 114615008011 active site 114615008012 phosphorylation site [posttranslational modification] 114615008013 intermolecular recognition site; other site 114615008014 dimerization interface [polypeptide binding]; other site 114615008015 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 114615008016 DNA binding site [nucleotide binding] 114615008017 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 114615008018 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054 114615008019 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 114615008020 ATP binding site [chemical binding]; other site 114615008021 Mg2+ binding site [ion binding]; other site 114615008022 G-X-G motif; other site 114615008023 Cytochrome c biogenesis factor [Posttranslational modification, protein turnover, chaperones]; Region: COG4235 114615008024 cytochrome c-type biogenesis protein CcmI; Region: cytochro_ccmI; TIGR03142 114615008025 cytochrome c-type biogenesis protein CcmE; Reviewed; Region: PRK13254 114615008026 Cytochrome c biogenesis factor [Posttranslational modification, protein turnover, chaperones]; Region: CcmF; COG1138 114615008027 Cytochrome C biogenesis protein; Region: CcmH; pfam03918 114615008028 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 114615008029 dimerization interface [polypeptide binding]; other site 114615008030 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 114615008031 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 114615008032 dimer interface [polypeptide binding]; other site 114615008033 putative CheW interface [polypeptide binding]; other site 114615008034 Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840 114615008035 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 114615008036 dimerization interface [polypeptide binding]; other site 114615008037 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 114615008038 dimer interface [polypeptide binding]; other site 114615008039 putative CheW interface [polypeptide binding]; other site 114615008040 AAA domain; Region: AAA_21; pfam13304 114615008041 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 114615008042 ABC transporter signature motif; other site 114615008043 Walker B; other site 114615008044 D-loop; other site 114615008045 H-loop/switch region; other site 114615008046 periplasmic serine protease, Do/DeqQ family; Region: degP_htrA_DO; TIGR02037 114615008047 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 114615008048 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 114615008049 protein binding site [polypeptide binding]; other site 114615008050 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 114615008051 protein binding site [polypeptide binding]; other site 114615008052 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 114615008053 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 114615008054 active site 114615008055 phosphorylation site [posttranslational modification] 114615008056 intermolecular recognition site; other site 114615008057 dimerization interface [polypeptide binding]; other site 114615008058 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 114615008059 DNA binding site [nucleotide binding] 114615008060 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 114615008061 dimerization interface [polypeptide binding]; other site 114615008062 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 114615008063 dimer interface [polypeptide binding]; other site 114615008064 phosphorylation site [posttranslational modification] 114615008065 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 114615008066 ATP binding site [chemical binding]; other site 114615008067 Mg2+ binding site [ion binding]; other site 114615008068 G-X-G motif; other site 114615008069 bifunctional glutamine-synthetase adenylyltransferase/deadenyltransferase; Provisional; Region: PRK14108 114615008070 Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401 114615008071 metal binding triad; other site 114615008072 GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335 114615008073 Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401 114615008074 metal binding triad; other site 114615008075 GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335 114615008076 Adenylyl- / guanylyl cyclase, catalytic domain; Region: CYCc; smart00044 114615008077 cyclase homology domain; Region: CHD; cd07302 114615008078 nucleotidyl binding site; other site 114615008079 metal binding site [ion binding]; metal-binding site 114615008080 dimer interface [polypeptide binding]; other site 114615008081 Protein of unknown function (DUF3303); Region: DUF3303; pfam11746 114615008082 Caspase domain; Region: Peptidase_C14; pfam00656 114615008083 glutamate and aspartate transporter subunit; Provisional; Region: PRK10797 114615008084 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 114615008085 substrate binding pocket [chemical binding]; other site 114615008086 membrane-bound complex binding site; other site 114615008087 hinge residues; other site 114615008088 dihydroxy-acid dehydratase; Provisional; Region: PRK12448 114615008089 CopC domain; Region: CopC; pfam04234 114615008090 Copper resistance protein D; Region: CopD; cl00563 114615008091 Protein of unknown function (DUF3455); Region: DUF3455; pfam11937 114615008092 isocitrate dehydrogenase; Validated; Region: PRK08299 114615008093 rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: LasT; COG0565 114615008094 SpoU rRNA Methylase family; Region: SpoU_methylase; cl17307 114615008095 Domain of unknown function, appears to be related to a diverse group of endonucleases; Region: Endonuclease_DUF559; cd01038 114615008096 putative active site [active] 114615008097 TPR repeat; Region: TPR_11; pfam13414 114615008098 Tetratricopeptide repeat; Region: TPR_1; pfam00515 114615008099 Calpains, domains IIa, IIb; calcium-dependent cytoplasmic cysteine proteinases, papain-like. Functions in cytoskeletal remodeling processes, cell differentiation, apoptosis and signal transduction; Region: CysPc; cl00051 114615008100 catalytic site [active] 114615008101 A sub-family of peptidase C39 which contains Cyclolysin and Hemolysin processing peptidases. Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the "double-glycine...; Region: Peptidase_C39_likeA; cd02417 114615008102 type I secretion system ABC transporter, HlyB family; Region: type_I_sec_HlyB; TIGR01846 114615008103 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 114615008104 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 114615008105 Walker A/P-loop; other site 114615008106 ATP binding site [chemical binding]; other site 114615008107 Q-loop/lid; other site 114615008108 ABC transporter signature motif; other site 114615008109 Walker B; other site 114615008110 D-loop; other site 114615008111 H-loop/switch region; other site 114615008112 type I secretion membrane fusion protein, HlyD family; Region: type_I_hlyD; TIGR01843 114615008113 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 114615008114 HlyD family secretion protein; Region: HlyD_3; pfam13437 114615008115 Uncharacterized protein conserved in bacteria (DUF2336); Region: DUF2336; pfam10098 114615008116 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 114615008117 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 114615008118 OsmC-like protein; Region: OsmC; pfam02566 114615008119 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 114615008120 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 114615008121 active site 114615008122 Rhodanese-related sulfurtransferase [Inorganic ion transport and metabolism]; Region: SseA; COG2897 114615008123 Rhodanese-like domain; Region: Rhodanese; pfam00581 114615008124 active site residue [active] 114615008125 Thiosulfate sulfurtransferase (TST), C-terminal, catalytic domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the second repeat. Only the second repeat contains the catalytically active Cys residue; Region: TST_Repeat_2; cd01449 114615008126 active site residue [active] 114615008127 ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components [Inorganic ion transport and metabolism]; Region: TauA; COG0715 114615008128 NMT1-like family; Region: NMT1_2; pfam13379 114615008129 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 114615008130 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 114615008131 dimer interface [polypeptide binding]; other site 114615008132 conserved gate region; other site 114615008133 putative PBP binding loops; other site 114615008134 ABC-ATPase subunit interface; other site 114615008135 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 114615008136 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 114615008137 Walker A/P-loop; other site 114615008138 ATP binding site [chemical binding]; other site 114615008139 Q-loop/lid; other site 114615008140 ABC transporter signature motif; other site 114615008141 Walker B; other site 114615008142 D-loop; other site 114615008143 H-loop/switch region; other site 114615008144 cyanate hydratase; Validated; Region: PRK02866 114615008145 Cyanase C-terminal domain. Cyanase (Cyanate lyase) is responsible for the hydrolysis of cyanate. It catalyzes the reaction of cyanate with bicarbonate to produce ammonia and carbon dioxide. This allows organisms that possess the enzyme to overcome the...; Region: Cyanase_C; cd00559 114615008146 oligomer interface [polypeptide binding]; other site 114615008147 active site 114615008148 Domain of unknown function (DUF1476); Region: DUF1476; pfam07345 114615008149 phosphoribosylaminoimidazole-succinocarboxamide synthase; Reviewed; Region: PRK09362 114615008150 bacterial and archaeal 5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide (SAICAR) synthase; Region: SAICAR_synt_PurC; cd01415 114615008151 ATP binding site [chemical binding]; other site 114615008152 active site 114615008153 substrate binding site [chemical binding]; other site 114615008154 phosphoribosylformylglycinamidine synthase subunit PurS; Reviewed; Region: PRK05974 114615008155 phosphoribosylformylglycinamidine synthase I; Provisional; Region: PRK03619 114615008156 Type 1 glutamine amidotransferase (GATase1)-like domain found in Formylglycinamide ribonucleotide amidotransferase; Region: GATase1_FGAR_AT; cd01740 114615008157 putative active site [active] 114615008158 catalytic triad [active] 114615008159 Protein of unknown function (DUF1236); Region: DUF1236; pfam06823 114615008160 Uncharacterized protein conserved in bacteria containing a divergent form of TPR repeats [Function unknown]; Region: COG4700 114615008161 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 114615008162 TPR motif; other site 114615008163 binding surface 114615008164 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 114615008165 CoenzymeA binding site [chemical binding]; other site 114615008166 subunit interaction site [polypeptide binding]; other site 114615008167 PHB binding site; other site 114615008168 phosphoribosylformylglycinamidine synthase II; Provisional; Region: PRK01213 114615008169 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), first repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat1; cd02203 114615008170 dimerization interface [polypeptide binding]; other site 114615008171 ATP binding site [chemical binding]; other site 114615008172 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), second repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat2; cd02204 114615008173 dimerization interface [polypeptide binding]; other site 114615008174 ATP binding site [chemical binding]; other site 114615008175 Acyltransferase family; Region: Acyl_transf_3; pfam01757 114615008176 glucans biosynthesis protein; Provisional; Region: opgC; PRK03854 114615008177 Small integral membrane protein [Function unknown]; Region: COG5487; cl17674 114615008178 Domain of unknown function (DUF427); Region: DUF427; pfam04248 114615008179 Stress-induced morphogen (activity unknown) [Signal transduction mechanisms]; Region: BolA; COG0271 114615008180 Bacterial low temperature requirement A protein (LtrA); Region: LtrA; cl01754 114615008181 dimethylhistidine N-methyltransferase; Region: egtD_ergothio; TIGR03438 114615008182 Uncharacterized conserved protein (DUF2260); Region: DUF2260; pfam10017 114615008183 ergothioneine biosynthesis protein EgtB; Region: egtB_TIGR03440 114615008184 Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; pfam03781 114615008185 Glutaredoxin (GRX) family, PKC-interacting cousin of TRX (PICOT)-like subfamily; composed of PICOT and GRX-PICOT-like proteins. The non-PICOT members of this family contain only the GRX-like domain, whereas PICOT contains an N-terminal TRX-like domain...; Region: GRX_PICOT_like; cd03028 114615008186 putative GSH binding site [chemical binding]; other site 114615008187 catalytic residues [active] 114615008188 Macro domain, Appr-1"-pase_like family. The macro domain is a high-affinity ADP-ribose binding module found in a variety of proteins as a stand-alone domain or in combination with other domains like in histone macroH2A and some PARPs (poly...; Region: Macro_Appr_pase_like; cd02908 114615008189 putative ADP-ribose binding site [chemical binding]; other site 114615008190 putative active site [active] 114615008191 Beta-lactamase; Region: Beta-lactamase; pfam00144 114615008192 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 114615008193 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 114615008194 Beta-eliminating lyase; Region: Beta_elim_lyase; pfam01212 114615008195 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 114615008196 catalytic residue [active] 114615008197 30S ribosomal protein S4; Validated; Region: rpsD; PRK05327 114615008198 Ribosomal protein S4/S9 N-terminal domain; Region: Ribosomal_S4; pfam00163 114615008199 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 114615008200 RNA binding surface [nucleotide binding]; other site 114615008201 Cupin domain; Region: Cupin_2; pfam07883 114615008202 HpcH/HpaI aldolase/citrate lyase family; Region: HpcH_HpaI; cl17231 114615008203 glutamate racemase; Provisional; Region: PRK00865 114615008204 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 114615008205 putative DNA binding site [nucleotide binding]; other site 114615008206 dimerization interface [polypeptide binding]; other site 114615008207 putative Zn2+ binding site [ion binding]; other site 114615008208 Putative hydrophobic ligand-binding SRPBCC domain of Micromonospora echinospora CalC, human Aha1, and related proteins; Region: SRPBCC_CalC_Aha1-like; cd07814 114615008209 putative hydrophobic ligand binding site [chemical binding]; other site 114615008210 Uncharacterized conserved protein [Function unknown]; Region: COG3791 114615008211 Protein of unknown function, DUF393; Region: DUF393; pfam04134 114615008212 D-alanyl-alanine synthetase A; Reviewed; Region: ddl; PRK01966 114615008213 D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820 114615008214 ATP-grasp domain; Region: ATP-grasp_4; cl17255 114615008215 Staphylococcal nuclease homologues; Region: SNc; smart00318 114615008216 Staphylococcal nuclease homologues. SNase homologues are found in bacteria, archaea, and eukaryotes. They contain no disufide bonds; Region: SNc; cl00140 114615008217 Catalytic site; other site 114615008218 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920 114615008219 HWE histidine kinase; Region: HWE_HK; smart00911 114615008220 Medium chain dehydrogenases/reductase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR7; cd08276 114615008221 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 114615008222 putative NAD(P) binding site [chemical binding]; other site 114615008223 putative DMT superfamily transporter inner membrane protein; Provisional; Region: PRK11272 114615008224 EamA-like transporter family; Region: EamA; pfam00892 114615008225 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 114615008226 M20 Peptidase Aminoacylase 1 subfamily; Region: M20_Acy1_like1; cd05666 114615008227 metal binding site [ion binding]; metal-binding site 114615008228 putative dimer interface [polypeptide binding]; other site 114615008229 zinc-ribbon domain; Region: zinc_ribbon_5; cl11777 114615008230 Uncharacterized conserved protein [Function unknown]; Region: COG3025 114615008231 Uncharacterized subgroup of the CYTH-like superfamily having an associated CHAD domain; Region: CYTH-like_Pase_CHAD; cd07756 114615008232 putative active site [active] 114615008233 putative metal binding residues [ion binding]; other site 114615008234 signature motif; other site 114615008235 putative triphosphate binding site [ion binding]; other site 114615008236 The CHAD domain is an alpha-helical domain functionally associated with some members of the adenylate cyclase family; Region: CHAD; smart00880 114615008237 Exopolysaccharide synthesis, ExoD; Region: ExoD; pfam06055 114615008238 integral membrane protein, TerC family; Region: R_switched_Alx; TIGR03718 114615008239 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; pfam00781 114615008240 putative lipid kinase; Reviewed; Region: PRK13057 114615008241 FtsH Extracellular; Region: FtsH_ext; pfam06480 114615008242 ATP-dependent metalloprotease FtsH; Region: FtsH_fam; TIGR01241 114615008243 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 114615008244 Walker A motif; other site 114615008245 ATP binding site [chemical binding]; other site 114615008246 Walker B motif; other site 114615008247 arginine finger; other site 114615008248 Peptidase family M41; Region: Peptidase_M41; pfam01434 114615008249 Cytochrome b (N-terminus)/b6/petB: Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria; Region: Cytochrome_b_N; cl00859 114615008250 Cytochrome B561 [Energy production and conversion]; Region: CybB; COG3038 114615008251 Cytochrome B561 [Energy production and conversion]; Region: CybB; COG3038 114615008252 adenylosuccinate lyase; Provisional; Region: PRK07492 114615008253 Adenylsuccinate lyase (ASL)_subgroup 1; Region: Adenylsuccinate_lyase_1; cd01360 114615008254 tetramer interface [polypeptide binding]; other site 114615008255 active site 114615008256 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 114615008257 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 114615008258 S1/P1 nucleases and related enzymes; Region: S1-P1_nuclease; cd11010 114615008259 active site 114615008260 Zn binding site [ion binding]; other site 114615008261 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 114615008262 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cd00838 114615008263 active site 114615008264 metal binding site [ion binding]; metal-binding site 114615008265 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 114615008266 Catalytic domain of Protein Kinases; Region: PKc; cd00180 114615008267 active site 114615008268 ATP binding site [chemical binding]; other site 114615008269 substrate binding site [chemical binding]; other site 114615008270 activation loop (A-loop); other site 114615008271 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 114615008272 Ligand Binding Site [chemical binding]; other site 114615008273 C4-dicarboxylate transporter DctA; Reviewed; Region: PRK01663 114615008274 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 114615008275 hypothetical protein; Provisional; Region: PRK11171 114615008276 Cupin domain; Region: Cupin_2; pfam07883 114615008277 Cupin domain; Region: Cupin_2; pfam07883 114615008278 Ureidoglycolate hydrolase [Nucleotide transport and metabolism]; Region: DAL3; COG3194 114615008279 Ureidoglycolate hydrolase; Region: Ureidogly_hydro; pfam04115 114615008280 Pentose-5-phosphate-3-epimerase [Carbohydrate transport and metabolism]; Region: Rpe; COG0036 114615008281 Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose...; Region: RPE; cd00429 114615008282 substrate binding site [chemical binding]; other site 114615008283 hexamer interface [polypeptide binding]; other site 114615008284 metal binding site [ion binding]; metal-binding site 114615008285 EF hand; Region: EF_hand_3; pfam13202 114615008286 EF-hand domain pair; Region: EF_hand_5; pfam13499 114615008287 Ca2+ binding site [ion binding]; other site 114615008288 nylC-like family; composed of proteins with similarity to Flavobacterium endo-type 6-aminohexanoate-oligomer hydrolase (EIII), the product of the nylon oligomer degradation gene, nylC. EIII is an amide hydrolase that catalyzes the degradation of...; Region: nylC_like; cd02252 114615008289 putative active site pocket [active] 114615008290 cleavage site 114615008291 PAS domain S-box; Region: sensory_box; TIGR00229 114615008292 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 114615008293 putative active site [active] 114615008294 heme pocket [chemical binding]; other site 114615008295 PAS domain S-box; Region: sensory_box; TIGR00229 114615008296 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 114615008297 putative active site [active] 114615008298 heme pocket [chemical binding]; other site 114615008299 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 114615008300 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 114615008301 dimer interface [polypeptide binding]; other site 114615008302 phosphorylation site [posttranslational modification] 114615008303 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 114615008304 ATP binding site [chemical binding]; other site 114615008305 Mg2+ binding site [ion binding]; other site 114615008306 G-X-G motif; other site 114615008307 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 114615008308 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 114615008309 active site 114615008310 phosphorylation site [posttranslational modification] 114615008311 intermolecular recognition site; other site 114615008312 dimerization interface [polypeptide binding]; other site 114615008313 Response regulator receiver domain; Region: Response_reg; pfam00072 114615008314 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 114615008315 active site 114615008316 phosphorylation site [posttranslational modification] 114615008317 intermolecular recognition site; other site 114615008318 dimerization interface [polypeptide binding]; other site 114615008319 ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683 114615008320 Type I periplasmic ligand-binding domain of ABC (Atpase Binding Cassette)-type active transport systems that are involved in the transport of all three branched chain aliphatic amino acids (leucine, isoleucine and valine); Region: PBP1_ABC_LIVBP_like; cd06342 114615008321 dimerization interface [polypeptide binding]; other site 114615008322 ligand binding site [chemical binding]; other site 114615008323 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410 114615008324 ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224 114615008325 Walker A/P-loop; other site 114615008326 ATP binding site [chemical binding]; other site 114615008327 Q-loop/lid; other site 114615008328 ABC transporter signature motif; other site 114615008329 Walker B; other site 114615008330 D-loop; other site 114615008331 H-loop/switch region; other site 114615008332 leucine/isoleucine/valine transporter ATP-binding subunit; Provisional; Region: livG; PRK11300 114615008333 ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219 114615008334 Walker A/P-loop; other site 114615008335 ATP binding site [chemical binding]; other site 114615008336 Q-loop/lid; other site 114615008337 ABC transporter signature motif; other site 114615008338 Walker B; other site 114615008339 D-loop; other site 114615008340 H-loop/switch region; other site 114615008341 Domain of unknown function (DUF3382); Region: DUF3382; pfam11862 114615008342 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 114615008343 TM-ABC transporter signature motif; other site 114615008344 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 114615008345 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 114615008346 TM-ABC transporter signature motif; other site 114615008347 3-oxoadipate enol-lactonase; Region: protocat_pcaD; TIGR02427 114615008348 Carbon monoxide dehydrogenase subunit G (CoxG); Region: CoxG; cd05018 114615008349 putative hydrophobic ligand binding site [chemical binding]; other site 114615008350 Aerobic-type carbon monoxide dehydrogenase, small subunit CoxS/CutS homologs [Energy production and conversion]; Region: CoxS; COG2080 114615008351 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 114615008352 catalytic loop [active] 114615008353 iron binding site [ion binding]; other site 114615008354 [2Fe-2S] binding domain; Region: Fer2_2; pfam01799 114615008355 Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM/CutM homologs [Energy production and conversion]; Region: CoxM; COG1319 114615008356 CO dehydrogenase flavoprotein C-terminal domain; Region: CO_deh_flav_C; smart01092 114615008357 MoxR-like ATPases [General function prediction only]; Region: COG0714 114615008358 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 114615008359 Walker A motif; other site 114615008360 ATP binding site [chemical binding]; other site 114615008361 Walker B motif; other site 114615008362 arginine finger; other site 114615008363 Protein containing von Willebrand factor type A (vWA) domain [General function prediction only]; Region: CoxE; COG3552 114615008364 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198 114615008365 metal ion-dependent adhesion site (MIDAS); other site 114615008366 XdhC and CoxI family; Region: XdhC_CoxI; pfam02625 114615008367 Xanthine and CO dehydrogenases maturation factor, XdhC/CoxF family [Posttranslational modification, protein turnover, chaperones]; Region: XdhC; COG1975 114615008368 XdhC Rossmann domain; Region: XdhC_C; pfam13478 114615008369 MoeA_like. This domain is similar to a domain found in a variety of proteins involved in biosynthesis of molybdopterin cofactor, like MoaB, MogA, and MoeA. There this domain is presumed to bind molybdopterin. The exact function of this subgroup is...; Region: MoeA_like; cd03522 114615008370 putative MPT binding site; other site 114615008371 GT_2_like_f is a subfamily of the glycosyltransferase family 2 (GT-2) with unknown function; Region: GT_2_like_f; cd04182 114615008372 molybdopterin-guanine dinucleotide biosynthesis protein MobA; Reviewed; Region: mobA; PRK00317 114615008373 Ligand binding site; other site 114615008374 metal-binding site 114615008375 Domain of unknown function (DUF4189); Region: DUF4189; pfam13827 114615008376 Protein of unknown function (DUF2000); Region: DUF2000; pfam09391 114615008377 Zn-dependent alcohol dehydrogenases [General function prediction only]; Region: AdhP; COG1064 114615008378 Cinnamyl alcohol dehydrogenases (CAD); Region: CAD3; cd08297 114615008379 NAD binding site [chemical binding]; other site 114615008380 substrate binding site [chemical binding]; other site 114615008381 catalytic Zn binding site [ion binding]; other site 114615008382 tetramer interface [polypeptide binding]; other site 114615008383 structural Zn binding site [ion binding]; other site 114615008384 NAD-dependent, lactate dehydrogenase-like, 2-hydroxycarboxylate dehydrogenase family; Region: LDH_MDH_like; cl17195 114615008385 alpha-galactosidase; Provisional; Region: PRK15076 114615008386 NAD(P) binding site [chemical binding]; other site 114615008387 LDH/MDH dimer interface [polypeptide binding]; other site 114615008388 substrate binding site [chemical binding]; other site 114615008389 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 114615008390 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 114615008391 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 114615008392 HlyD family secretion protein; Region: HlyD_3; pfam13437 114615008393 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 114615008394 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 114615008395 Walker A/P-loop; other site 114615008396 ATP binding site [chemical binding]; other site 114615008397 Q-loop/lid; other site 114615008398 ABC transporter signature motif; other site 114615008399 Walker B; other site 114615008400 D-loop; other site 114615008401 H-loop/switch region; other site 114615008402 ABC-type Na+ efflux pump, permease component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatB; COG1668 114615008403 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 114615008404 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 114615008405 Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114 114615008406 cyclase homology domain; Region: CHD; cd07302 114615008407 nucleotidyl binding site; other site 114615008408 metal binding site [ion binding]; metal-binding site 114615008409 dimer interface [polypeptide binding]; other site 114615008410 Tannase and feruloyl esterase; Region: Tannase; pfam07519 114615008411 Protein of unknown function, DUF488; Region: DUF488; pfam04343 114615008412 Protein of unknown function DUF72; Region: DUF72; pfam01904 114615008413 dolichyl-phosphate beta-D-mannosyltransferase; Region: PLN02726 114615008414 DPM1_like represents putative enzymes similar to eukaryotic DPM1; Region: DPM1_like; cd06442 114615008415 Ligand binding site; other site 114615008416 Putative Catalytic site; other site 114615008417 DXD motif; other site 114615008418 Predicted membrane protein [Function unknown]; Region: COG2246 114615008419 GtrA-like protein; Region: GtrA; pfam04138 114615008420 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; pfam13231 114615008421 methyltransferase, FkbM family; Region: fkbM_fam; TIGR01444 114615008422 Protein of unknown function (DUF2778); Region: DUF2778; pfam10908 114615008423 Aerobic-type carbon monoxide dehydrogenase, small subunit CoxS/CutS homologs [Energy production and conversion]; Region: CoxS; COG2080 114615008424 [2Fe-2S] binding domain; Region: Fer2_2; pfam01799 114615008425 Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM/CutM homologs [Energy production and conversion]; Region: CoxM; COG1319 114615008426 CO dehydrogenase flavoprotein C-terminal domain; Region: CO_deh_flav_C; smart01092 114615008427 Aerobic-type carbon monoxide dehydrogenase, large subunit CoxL/CutL homologs [Energy production and conversion]; Region: CoxL; COG1529 114615008428 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; smart01008 114615008429 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 114615008430 Restriction endonuclease [Defense mechanisms]; Region: McrA; COG1403 114615008431 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 114615008432 active site 114615008433 hypothetical protein; Reviewed; Region: PRK09588 114615008434 Uncharacterized protein family UPF0027; Region: UPF0027; pfam01139 114615008435 signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227 114615008436 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 114615008437 Catalytic site [active] 114615008438 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 114615008439 Isochorismatase family; Region: Isochorismatase; pfam00857 114615008440 Nicotinamidase_ related amidohydrolases. Cysteine hydrolases of unknown function that share the catalytic triad with other amidohydrolases, like nicotinamidase, which converts nicotinamide to nicotinic acid and ammonia; Region: nicotinamidase_related; cd01014 114615008441 catalytic triad [active] 114615008442 conserved cis-peptide bond; other site 114615008443 Transcriptional regulator [Transcription]; Region: LysR; COG0583 114615008444 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 114615008445 LysR substrate binding domain; Region: LysR_substrate; pfam03466 114615008446 dimerization interface [polypeptide binding]; other site 114615008447 chaperonin GroEL; Reviewed; Region: groEL; PRK12849 114615008448 GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344 114615008449 ring oligomerisation interface [polypeptide binding]; other site 114615008450 ATP/Mg binding site [chemical binding]; other site 114615008451 stacking interactions; other site 114615008452 hinge regions; other site 114615008453 Chaperonin 10 Kd subunit (cpn10 or GroES); Cpn10 cooperates with chaperonin 60 (cpn60 or GroEL), an ATPase, to assist the folding and assembly of proteins and is found in eubacterial cytosol, as well as in the matrix of mitochondria and chloroplasts. It...; Region: cpn10; cd00320 114615008454 oligomerisation interface [polypeptide binding]; other site 114615008455 mobile loop; other site 114615008456 roof hairpin; other site 114615008457 Usg-like family; Region: Usg; pfam06233 114615008458 Cupin domain; Region: Cupin_2; cl17218 114615008459 Predicted acyltransferases [Lipid metabolism]; Region: COG1835 114615008460 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 114615008461 Nucleoside permease [Nucleotide transport and metabolism]; Region: NupC; COG1972 114615008462 Na+ dependent nucleoside transporter N-terminus; Region: Nucleos_tra2_N; pfam01773 114615008463 Nucleoside recognition; Region: Gate; pfam07670 114615008464 Na+ dependent nucleoside transporter C-terminus; Region: Nucleos_tra2_C; pfam07662 114615008465 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 114615008466 H+ Antiporter protein; Region: 2A0121; TIGR00900 114615008467 putative substrate translocation pore; other site 114615008468 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG1943 114615008469 classical (c) SDRs; Region: SDR_c; cd05233 114615008470 acetoacetyl-CoA reductase; Region: AcAcCoA_reduct; TIGR01829 114615008471 NAD(P) binding site [chemical binding]; other site 114615008472 active site 114615008473 Predicted proteasome-type protease [Posttranslational modification, protein turnover, chaperones]; Region: COG3484 114615008474 The Ntn hydrolases (N-terminal nucleophile) are a diverse superfamily of of enzymes that are activated autocatalytically via an N-terminally lcated nucleophilic amino acid. N-terminal nucleophile (NTN-) hydrolase superfamily, which contains a...; Region: Ntn_hydrolase; cl00467 114615008475 active site 114615008476 Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305 114615008477 Bacterial transglutaminase-like N-terminal region; Region: Bact_transglu_N; pfam08379 114615008478 Transglutaminase-like superfamily; Region: Transglut_core; pfam01841 114615008479 A predicted alpha-helical domain with a conserved ER motif; Region: Alpha-E; pfam04168 114615008480 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2307 114615008481 Uncharacterized conserved protein [Function unknown]; Region: COG2308 114615008482 Predicted nucleotide-utilizing enzyme related to molybdopterin-biosynthesis enzyme MoeA [General function prediction only]; Region: CinA; COG1058 114615008483 Competence-damaged protein. CinA is the first gene in the competence- inducible (cin) operon and is thought to be specifically required at some stage in the process of transformation. This domain is closely related to a domain, found in a variety of...; Region: cinA; cd00885 114615008484 putative MPT binding site; other site 114615008485 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 114615008486 active site 114615008487 CIMS - Cobalamine-independent methonine synthase, or MetE, C-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_C_terminal_like; cd03311 114615008488 substrate binding site [chemical binding]; other site 114615008489 methionine synthase; Provisional; Region: PRK01207 114615008490 THF binding site; other site 114615008491 zinc-binding site [ion binding]; other site 114615008492 GSH-dependent disulfide bond oxidoreductase; Provisional; Region: PRK13972 114615008493 GST_N family, Ure2p-like subfamily; composed of the Saccharomyces cerevisiae Ure2p and related GSTs. Ure2p is a regulator for nitrogen catabolism in yeast. It represses the expression of several gene products involved in the use of poor nitrogen sources...; Region: GST_N_Ure2p_like; cd03048 114615008494 C-terminal domain interface [polypeptide binding]; other site 114615008495 GSH binding site (G-site) [chemical binding]; other site 114615008496 dimer interface [polypeptide binding]; other site 114615008497 C-terminal, alpha helical domain of the Glutathione S-transferase family; Region: GST_C_family; cl02776 114615008498 N-terminal domain interface [polypeptide binding]; other site 114615008499 dimer interface [polypeptide binding]; other site 114615008500 substrate binding pocket (H-site) [chemical binding]; other site 114615008501 2-hydroxychromene-2-carboxylate isomerase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: NahD; COG3917 114615008502 DsbA family, 2-hydroxychromene-2-carboxylate (HCCA) isomerase subfamily; HCCA isomerase is a glutathione (GSH) dependent enzyme involved in the naphthalene catabolic pathway. It converts HCCA, a hemiketal formed spontaneously after ring cleavage of 1; Region: DsbA_HCCA_Iso; cd03022 114615008503 putative catalytic residue [active] 114615008504 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 114615008505 Quinone oxidoreductase (QOR); Region: QOR1; cd08241 114615008506 NAD(P) binding site [chemical binding]; other site 114615008507 enoyl-CoA hydratase; Provisional; Region: PRK08260 114615008508 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 114615008509 substrate binding site [chemical binding]; other site 114615008510 oxyanion hole (OAH) forming residues; other site 114615008511 trimer interface [polypeptide binding]; other site 114615008512 amidase; Provisional; Region: PRK07042 114615008513 Amidase; Region: Amidase; cl11426 114615008514 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 114615008515 M20 Peptidase Aminoacylase 1 subfamily; Region: M20_Acy1_like1; cd05666 114615008516 metal binding site [ion binding]; metal-binding site 114615008517 putative dimer interface [polypeptide binding]; other site 114615008518 Protein of unknown function (DUF1485); Region: DUF1485; pfam07364 114615008519 Uncharacterized conserved protein [Function unknown]; Region: COG5476 114615008520 MlrC C-terminus; Region: MlrC_C; pfam07171 114615008521 ATPase components of various ABC-type transport systems, contain duplicated ATPase [General function prediction only]; Region: COG1123 114615008522 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 114615008523 Walker A/P-loop; other site 114615008524 ATP binding site [chemical binding]; other site 114615008525 Q-loop/lid; other site 114615008526 ABC transporter signature motif; other site 114615008527 Walker B; other site 114615008528 D-loop; other site 114615008529 H-loop/switch region; other site 114615008530 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 114615008531 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 114615008532 Walker A/P-loop; other site 114615008533 ATP binding site [chemical binding]; other site 114615008534 Q-loop/lid; other site 114615008535 ABC transporter signature motif; other site 114615008536 Walker B; other site 114615008537 D-loop; other site 114615008538 H-loop/switch region; other site 114615008539 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 114615008540 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 114615008541 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 114615008542 dimer interface [polypeptide binding]; other site 114615008543 conserved gate region; other site 114615008544 putative PBP binding loops; other site 114615008545 ABC-ATPase subunit interface; other site 114615008546 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 114615008547 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 114615008548 dimer interface [polypeptide binding]; other site 114615008549 conserved gate region; other site 114615008550 putative PBP binding loops; other site 114615008551 ABC-ATPase subunit interface; other site 114615008552 hypothetical protein; Provisional; Region: PRK07338 114615008553 M20 Peptidase Glutamate carboxypeptidase, a periplasmic enzyme; Region: M20_CPDG2; cd03885 114615008554 metal binding site [ion binding]; metal-binding site 114615008555 dimer interface [polypeptide binding]; other site 114615008556 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 114615008557 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_16; cd08502 114615008558 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 114615008559 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_16; cd08502 114615008560 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 114615008561 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_16; cd08502 114615008562 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 114615008563 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 114615008564 dimer interface [polypeptide binding]; other site 114615008565 putative CheW interface [polypeptide binding]; other site 114615008566 MCP-signal associated domain; Region: MCPsignal_assoc; pfam13682 114615008567 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 114615008568 dimerization interface [polypeptide binding]; other site 114615008569 putative DNA binding site [nucleotide binding]; other site 114615008570 putative Zn2+ binding site [ion binding]; other site 114615008571 Ligand-binding SRPBCC domain of Micromonospora echinospora CalC and related proteins; Region: SRPBCC_CalC; cd08891 114615008572 putative hydrophobic ligand binding site [chemical binding]; other site 114615008573 CLM binding site; other site 114615008574 L1 loop; other site 114615008575 DNA binding site [nucleotide binding] 114615008576 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 114615008577 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 114615008578 C-terminal, alpha helical domain of the Glutathione S-transferase family; Region: GST_C_family; cd00299 114615008579 N-terminal domain interface [polypeptide binding]; other site 114615008580 PBP superfamily domain; Region: PBP_like_2; cl17296 114615008581 PBP superfamily domain; Region: PBP_like_2; cl17296 114615008582 Short-chain alcohol dehydrogenase of unknown specificity [General function prediction only]; Region: COG4221 114615008583 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 114615008584 NAD(P) binding site [chemical binding]; other site 114615008585 active site 114615008586 salicylate hydroxylase; Provisional; Region: PRK08163 114615008587 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 114615008588 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4391 114615008589 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 114615008590 serine acetyltransferase; Provisional; Region: cysE; PRK11132 114615008591 Serine acetyltransferase, N-terminal; Region: SATase_N; pfam06426 114615008592 Serine acetyltransferase (SAT): SAT catalyzes the CoA-dependent acetylation of the side chain hydroxyl group of L-serine to form O-acetylserine, as the first step of a two-step biosynthetic pathway in bacteria and plants leading to the formation of...; Region: LbH_SAT; cd03354 114615008593 trimer interface [polypeptide binding]; other site 114615008594 active site 114615008595 substrate binding site [chemical binding]; other site 114615008596 CoA binding site [chemical binding]; other site 114615008597 Protein of unknown function (DUF3126); Region: DUF3126; pfam11324 114615008598 Carbonic anhydrases/acetyltransferases, isoleucine patch superfamily [General function prediction only]; Region: PaaY; COG0663 114615008599 Gamma carbonic anhydrase-like: This family is composed of gamma carbonic anhydrase (CA), Ferripyochelin Binding Protein (FBP), E. coli paaY protein, and similar proteins. CAs are zinc-containing enzymes that catalyze the reversible hydration of carbon...; Region: LbH_gamma_CA_like; cd04645 114615008600 trimer interface [polypeptide binding]; other site 114615008601 putative metal binding site [ion binding]; other site 114615008602 Ribbon-helix-helix domain; Region: RHH_3; pfam12651 114615008603 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3666 114615008604 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 114615008605 Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751 114615008606 Dienelactone hydrolase family; Region: DLH; pfam01738 114615008607 Bacterial transglutaminase-like cysteine proteinase BTLCP; Region: BTLCP; pfam06035 114615008608 PilZ domain; Region: PilZ; pfam07238 114615008609 PilZ domain; Region: PilZ; pfam07238 114615008610 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5388 114615008611 PAS domain; Region: PAS_5; pfam07310 114615008612 Membrane associated serine protease [Amino acid transport and metabolism]; Region: COG0705 114615008613 FOG: CBS domain [General function prediction only]; Region: COG0517 114615008614 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair_10; cd04623 114615008615 hypothetical protein; Provisional; Region: PRK10279 114615008616 Patatins and Phospholipases; Region: Patatin_and_cPLA2; cl11396 114615008617 nucleophile elbow; other site 114615008618 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436 114615008619 putative Helix-turn-helix domain of transposase IS66; Region: HTH_Tnp_IS66; pfam13005 114615008620 Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050 114615008621 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3666 114615008622 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 114615008623 Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751 114615008624 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 114615008625 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 114615008626 WHG domain; Region: WHG; pfam13305 114615008627 O-Methyltransferase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3315 114615008628 Leucine carboxyl methyltransferase; Region: LCM; cl01306 114615008629 PAS domain S-box; Region: sensory_box; TIGR00229 114615008630 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 114615008631 putative active site [active] 114615008632 heme pocket [chemical binding]; other site 114615008633 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 114615008634 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 114615008635 metal binding site [ion binding]; metal-binding site 114615008636 active site 114615008637 I-site; other site 114615008638 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 114615008639 Nitroreductase-like family which includes NADH oxidase and arsenite oxidiase. NADH oxidase catalyses the oxidation of NAD(P)H and accepts a wide broad range of compounds as electron acceptors, such as nitrocompound. Arsenite oxidase in a...; Region: Arsenite_oxidase; cd02135 114615008640 putative FMN binding site [chemical binding]; other site 114615008641 threonyl-tRNA synthetase; Reviewed; Region: thrS; PRK00413 114615008642 TGS _ThrRS_N: ThrRS (threonyl-tRNA Synthetase) is a class II tRNA synthetase that couples threonine to its cognate tRNA. In addition to its catalytic and anticodon-binding domains, ThrRS has an N-terminal TGS domain, named after the ThrRS, GTPase, and...; Region: TGS_ThrRS_N; cd01667 114615008643 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863 114615008644 Threonyl-tRNA synthetase (ThrRS) class II core catalytic domain. ThrRS is a homodimer. It is responsible for the attachment of threonine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ThrRS_core; cd00771 114615008645 active site 114615008646 dimer interface [polypeptide binding]; other site 114615008647 motif 1; other site 114615008648 motif 2; other site 114615008649 motif 3; other site 114615008650 ThrRS Threonyl-anticodon binding domain. ThrRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: ThrRS_anticodon; cd00860 114615008651 anticodon binding site; other site 114615008652 Predicted periplasmic protein [Function unknown]; Region: COG3904 114615008653 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 114615008654 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 114615008655 putative substrate translocation pore; other site 114615008656 Amino acid permease; Region: AA_permease_2; pfam13520 114615008657 hypothetical protein; Validated; Region: PRK00041 114615008658 Predicted periplasmic protein [Function unknown]; Region: COG3904 114615008659 NifU homolog involved in Fe-S cluster formation [Energy production and conversion]; Region: IscU; COG0822 114615008660 Iron-sulfur cluster scaffold-like proteins; Region: IscU_like; cd06664 114615008661 trimerization site [polypeptide binding]; other site 114615008662 active site 114615008663 GTP cyclohydrolase I; Provisional; Region: folE; PRK09347 114615008664 GTP cyclohydrolase I; Provisional; Region: PLN03044 114615008665 active site 114615008666 phosphoribosyl-AMP cyclohydrolase; Reviewed; Region: hisI; PRK00051 114615008667 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 114615008668 N-acetyl-D-glucosamine binding site [chemical binding]; other site 114615008669 catalytic residue [active] 114615008670 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5330 114615008671 Uncharacterized protein conserved in bacteria (DUF2336); Region: DUF2336; pfam10098 114615008672 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cl00086 114615008673 putative binding surface; other site 114615008674 active site 114615008675 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 114615008676 Response regulator receiver domain; Region: Response_reg; pfam00072 114615008677 active site 114615008678 phosphorylation site [posttranslational modification] 114615008679 intermolecular recognition site; other site 114615008680 dimerization interface [polypeptide binding]; other site 114615008681 inorganic polyphosphate/ATP-NAD kinase; Reviewed; Region: ppnK; PRK04761 114615008682 CHASE2 domain; Region: CHASE2; pfam05226 114615008683 Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114 114615008684 cyclase homology domain; Region: CHD; cd07302 114615008685 nucleotidyl binding site; other site 114615008686 metal binding site [ion binding]; metal-binding site 114615008687 dimer interface [polypeptide binding]; other site 114615008688 Carboxypeptidase C (cathepsin A) [Amino acid transport and metabolism]; Region: COG2939 114615008689 Serine carboxypeptidase; Region: Peptidase_S10; cl08270 114615008690 Beta-lactamase; Region: Beta-lactamase; pfam00144 114615008691 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 114615008692 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 114615008693 TPR motif; other site 114615008694 TPR repeat; Region: TPR_11; pfam13414 114615008695 binding surface 114615008696 Opacity protein and related surface antigens [Cell envelope biogenesis, outer membrane]; Region: COG3637 114615008697 rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566 114615008698 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; smart00967 114615008699 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 114615008700 Predicted acyltransferases [Lipid metabolism]; Region: COG1835 114615008701 Protein of unknown function (DUF1211); Region: DUF1211; pfam06736 114615008702 Transcriptional regulator [Transcription]; Region: LysR; COG0583 114615008703 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 114615008704 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 114615008705 dimerization interface [polypeptide binding]; other site 114615008706 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084 114615008707 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 114615008708 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 114615008709 Uncharacterized Candidatus pelagibacter aldehyde dehydrogenase, DhaS-like; Region: ALDH_DhaS; cd07114 114615008710 NAD(P) binding site [chemical binding]; other site 114615008711 catalytic residues [active] 114615008712 N-carbamyl-D-amino acid amidohydrolase (DCase, class 6 nitrilases); Region: DCase; cd07569 114615008713 Predicted amidohydrolase [General function prediction only]; Region: COG0388 114615008714 tetramer interface [polypeptide binding]; other site 114615008715 active site 114615008716 catalytic triad [active] 114615008717 dimer interface [polypeptide binding]; other site 114615008718 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 114615008719 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_16; cd08502 114615008720 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 114615008721 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 114615008722 dimer interface [polypeptide binding]; other site 114615008723 conserved gate region; other site 114615008724 putative PBP binding loops; other site 114615008725 ABC-ATPase subunit interface; other site 114615008726 nickel ABC transporter, permease subunit NikC; Region: nickel_nikC; TIGR02790 114615008727 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 114615008728 dimer interface [polypeptide binding]; other site 114615008729 conserved gate region; other site 114615008730 putative PBP binding loops; other site 114615008731 ABC-ATPase subunit interface; other site 114615008732 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 114615008733 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 114615008734 Walker A/P-loop; other site 114615008735 ATP binding site [chemical binding]; other site 114615008736 Q-loop/lid; other site 114615008737 ABC transporter signature motif; other site 114615008738 Walker B; other site 114615008739 D-loop; other site 114615008740 H-loop/switch region; other site 114615008741 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 114615008742 dipeptide transporter ATP-binding subunit; Provisional; Region: dppF; PRK11308 114615008743 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 114615008744 Walker A/P-loop; other site 114615008745 ATP binding site [chemical binding]; other site 114615008746 Q-loop/lid; other site 114615008747 ABC transporter signature motif; other site 114615008748 Walker B; other site 114615008749 D-loop; other site 114615008750 H-loop/switch region; other site 114615008751 oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727 114615008752 tRNA-binding-domain-containing CsaA-like proteins. CsaA is a molecular chaperone with export related activities. CsaA has a putative tRNA binding activity. The functional unit of CsaA is a homodimer and this domain acts as a dimerization domain; Region: tRNA_bind_CsaA; cd02798 114615008753 dimer interface [polypeptide binding]; other site 114615008754 putative tRNA-binding site [nucleotide binding]; other site 114615008755 1,4-alpha-glucan branching enzyme [Carbohydrate transport and metabolism]; Region: GlgB; COG0296 114615008756 N-terminal Early set domain associated with the catalytic domain of prokaryotic glycogen branching enzyme; Region: E_set_GBE_prok_N; cd02855 114615008757 Alpha amylase catalytic domain found in Glycosyltrehalose trehalohydrolase (also called Maltooligosyl trehalose Trehalohydrolase); Region: AmyAc_GTHase; cd11325 114615008758 catalytic site [active] 114615008759 active site 114615008760 Alpha amylase, C-terminal all-beta domain; Region: Alpha-amylase_C; pfam02806 114615008761 NADH kinase; Region: PLN02929 114615008762 SPFH domain / Band 7 family; Region: Band_7; pfam01145 114615008763 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447 114615008764 Uncharacterized conserved protein [General function prediction only]; Region: COG4111 114615008765 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 114615008766 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 114615008767 dimer interface [polypeptide binding]; other site 114615008768 putative CheW interface [polypeptide binding]; other site 114615008769 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 114615008770 CoA-transferase family III; Region: CoA_transf_3; pfam02515 114615008771 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 114615008772 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 114615008773 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 114615008774 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 114615008775 active site 114615008776 Acyl-CoA dehydrogenase (ACAD) 10 and 11, N-terminal domain, and similar proteins. This subfamily is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs); Region: ACAD10_11_like; cd05154 114615008777 Phosphotransferase enzyme family; Region: APH; pfam01636 114615008778 putative active site [active] 114615008779 putative substrate binding site [chemical binding]; other site 114615008780 ATP binding site [chemical binding]; other site 114615008781 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK05565 114615008782 classical (c) SDRs; Region: SDR_c; cd05233 114615008783 NAD(P) binding site [chemical binding]; other site 114615008784 active site 114615008785 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 114615008786 catalytic core [active] 114615008787 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK07231 114615008788 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 114615008789 NAD(P) binding site [chemical binding]; other site 114615008790 active site 114615008791 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 114615008792 Beta-lactamase; Region: Beta-lactamase; pfam00144 114615008793 Periplasmic binding protein; Region: Peripla_BP_6; pfam13458 114615008794 Periplasmic solute-binding domain of active transport proteins that belong to the type I periplasmic binding fold protein family; Region: PBP1_SBP_like_1; cd06327 114615008795 putative ligand binding site [chemical binding]; other site 114615008796 preprotein translocase subunit SecE; Reviewed; Region: secE; PRK07597 114615008797 transcription antitermination protein NusG; Validated; Region: nusG; PRK05609 114615008798 Bacterial N-Utilization Substance G (NusG) N-terminal (NGN) domain, subgroup 1; Region: NGN_Bact_1; cd09891 114615008799 putative homodimer interface [polypeptide binding]; other site 114615008800 NusG contains an NGN domain at its N-terminus and KOW motif at its C-terminus; Region: KOW_NusG; cd06091 114615008801 heterodimer interface [polypeptide binding]; other site 114615008802 homodimer interface [polypeptide binding]; other site 114615008803 50S ribosomal protein L11; Validated; Region: rplK; PRK00140 114615008804 Ribosomal protein L11. Ribosomal protein L11, together with proteins L10 and L7/L12, and 23S rRNA, form the L7/L12 stalk on the surface of the large subunit of the ribosome. The homologous eukaryotic cytoplasmic protein is also called 60S ribosomal...; Region: Ribosomal_L11; cd00349 114615008805 23S rRNA interface [nucleotide binding]; other site 114615008806 L7/L12 interface [polypeptide binding]; other site 114615008807 putative thiostrepton binding site; other site 114615008808 L25 interface [polypeptide binding]; other site 114615008809 Ribosomal protein L1. The L1 protein, located near the E-site of the ribosome, forms part of the L1 stalk along with 23S rRNA. In bacteria and archaea, L1 functions both as a ribosomal protein that binds rRNA, and as a translation repressor that binds...; Region: Ribosomal_L1; cd00403 114615008810 mRNA/rRNA interface [nucleotide binding]; other site 114615008811 Lactate dehydrogenase and related dehydrogenases [Energy production and conversion / Coenzyme metabolism / General function prediction only]; Region: LdhA; COG1052 114615008812 Hydroxy(phenyl)pyruvate Reductase, D-isomer-specific 2-hydroxyacid-related dehydrogenase; Region: HPPR; cd12156 114615008813 putative ligand binding site [chemical binding]; other site 114615008814 NAD binding site [chemical binding]; other site 114615008815 catalytic site [active] 114615008816 Ribosomal protein L10 family, L10 subfamily; composed of bacterial 50S ribosomal protein and eukaryotic mitochondrial 39S ribosomal protein, L10. L10 occupies the L7/L12 stalk of the ribosome. The N-terminal domain (NTD) of L10 interacts with L11 protein...; Region: Ribosomal_L10; cd05797 114615008817 23S rRNA interface [nucleotide binding]; other site 114615008818 Interface with L7/L12 ribosomal proteins [polypeptide binding]; other site 114615008819 Ribosomal protein L7/L12. Ribosomal protein L7/L12 refers to the large ribosomal subunit proteins L7 and L12, which are identical except that L7 is acetylated at the N terminus. It is a component of the L7/L12 stalk, which is located at the surface of...; Region: Ribosomal_L7_L12; cd00387 114615008820 L11 interface [polypeptide binding]; other site 114615008821 putative EF-Tu interaction site [polypeptide binding]; other site 114615008822 putative EF-G interaction site [polypeptide binding]; other site 114615008823 DNA-directed RNA polymerase subunit beta; Reviewed; Region: rpoB; PRK00405 114615008824 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cl17585 114615008825 RNA polymerase Rpb2, domain 2; Region: RNA_pol_Rpb2_2; pfam04561 114615008826 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653 114615008827 RPB11 interaction site [polypeptide binding]; other site 114615008828 RPB12 interaction site [polypeptide binding]; other site 114615008829 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653 114615008830 RPB3 interaction site [polypeptide binding]; other site 114615008831 RPB1 interaction site [polypeptide binding]; other site 114615008832 RPB11 interaction site [polypeptide binding]; other site 114615008833 RPB10 interaction site [polypeptide binding]; other site 114615008834 RNA polymerase Rpb1, domain 1; Region: RNA_pol_Rpb1_1; pfam04997 114615008835 DNA-directed RNA polymerase, beta' subunit/160 kD subunit [Transcription]; Region: RpoC; COG0086 114615008836 RNA polymerase I subunit A N-terminus; Region: RPOLA_N; smart00663 114615008837 RNA polymerase Rpb1, domain 3; Region: RNA_pol_Rpb1_3; pfam04983 114615008838 RNA polymerase Rpb1, domain 4; Region: RNA_pol_Rpb1_4; pfam05000 114615008839 RNA polymerase Rpb1, domain 5; Region: RNA_pol_Rpb1_5; pfam04998 114615008840 Largest subunit of RNA polymerase (RNAP), C-terminal domain; Region: RNAP_largest_subunit_C; cl11429 114615008841 Rpb1 - Rpb6 interaction site [polypeptide binding]; other site 114615008842 Largest subunit of RNA polymerase (RNAP), C-terminal domain; Region: RNAP_largest_subunit_C; cl11429 114615008843 Largest subunit (beta') of Bacterial DNA-dependent RNA polymerase (RNAP), C-terminal domain; Region: RNAP_beta'_C; cd02655 114615008844 DNA binding site [nucleotide binding] 114615008845 Rpb1 (beta') - Rpb2 (beta) interaction site [polypeptide binding]; other site 114615008846 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 114615008847 Flavin containing amine oxidoreductase; Region: Amino_oxidase; pfam01593 114615008848 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 114615008849 S-adenosylmethionine binding site [chemical binding]; other site 114615008850 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 114615008851 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 114615008852 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 114615008853 Walker A/P-loop; other site 114615008854 ATP binding site [chemical binding]; other site 114615008855 Q-loop/lid; other site 114615008856 ABC transporter signature motif; other site 114615008857 Walker B; other site 114615008858 D-loop; other site 114615008859 H-loop/switch region; other site 114615008860 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases [Coenzyme metabolism / Energy production and conversion]; Region: UbiH; COG0654 114615008861 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3666 114615008862 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 114615008863 Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751 114615008864 S12-like family, 30S ribosomal protein S12 subfamily; S12 is located at the interface of the large and small ribosomal subunits of prokaryotes, chloroplasts and mitochondria, where it plays an important role in both tRNA and ribosomal subunit...; Region: Ribosomal_S12; cd03368 114615008865 S17 interaction site [polypeptide binding]; other site 114615008866 S8 interaction site; other site 114615008867 16S rRNA interaction site [nucleotide binding]; other site 114615008868 streptomycin interaction site [chemical binding]; other site 114615008869 23S rRNA interaction site [nucleotide binding]; other site 114615008870 aminoacyl-tRNA interaction site (A-site) [nucleotide binding]; other site 114615008871 30S ribosomal protein S7; Validated; Region: PRK05302 114615008872 elongation factor G; Reviewed; Region: PRK00007 114615008873 Elongation factor G (EF-G) family involved in both the elongation and ribosome recycling phases of protein synthesis; Region: EF-G; cd01886 114615008874 G1 box; other site 114615008875 putative GEF interaction site [polypeptide binding]; other site 114615008876 GTP/Mg2+ binding site [chemical binding]; other site 114615008877 Switch I region; other site 114615008878 G2 box; other site 114615008879 G3 box; other site 114615008880 Switch II region; other site 114615008881 G4 box; other site 114615008882 G5 box; other site 114615008883 EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088 114615008884 EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434 114615008885 EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G. Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713 114615008886 elongation factor Tu; Reviewed; Region: PRK00049 114615008887 Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884 114615008888 G1 box; other site 114615008889 GEF interaction site [polypeptide binding]; other site 114615008890 GTP/Mg2+ binding site [chemical binding]; other site 114615008891 Switch I region; other site 114615008892 G2 box; other site 114615008893 G3 box; other site 114615008894 Switch II region; other site 114615008895 G4 box; other site 114615008896 G5 box; other site 114615008897 EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697 114615008898 Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707 114615008899 Antibiotic Binding Site [chemical binding]; other site 114615008900 30S ribosomal protein S10; Reviewed; Region: rpsJ; PRK00596 114615008901 50S ribosomal protein L3; Validated; Region: rplC; PRK00001 114615008902 50S ribosomal protein L4; Provisional; Region: rplD; PRK05319 114615008903 50S ribosomal protein L23; Reviewed; Region: rplW; PRK05738 114615008904 50S ribosomal protein L2; Validated; Region: rplB; PRK09374 114615008905 Ribosomal Proteins L2, RNA binding domain; Region: Ribosomal_L2; pfam00181 114615008906 Ribosomal Proteins L2, C-terminal domain; Region: Ribosomal_L2_C; pfam03947 114615008907 30S ribosomal protein S19; Reviewed; Region: rpsS; PRK00357 114615008908 Ribosomal protein L22/L17e. L22 (L17 in eukaryotes) is a core protein of the large ribosomal subunit. It is the only ribosomal protein that interacts with all six domains of 23S rRNA, and is one of the proteins important for directing the proper...; Region: Ribosomal_L22; cd00336 114615008909 protein-rRNA interface [nucleotide binding]; other site 114615008910 putative translocon binding site; other site 114615008911 30S ribosomal protein S3; Reviewed; Region: rpsC; PRK00310 114615008912 K homology RNA-binding (KH) domain of the prokaryotic 30S small ribosomal subunit protein S3. S3 is part of the head region of the 30S ribosomal subunit and is believed to interact with mRNA as it threads its way from the latch into the channel. The KH...; Region: 30S_S3_KH; cd02412 114615008913 G-X-X-G motif; other site 114615008914 Ribosomal protein S3, C-terminal domain; Region: Ribosomal_S3_C; pfam00189 114615008915 Ribosomal_L16_L10e: L16 is an essential protein in the large ribosomal subunit of bacteria, mitochondria, and chloroplasts. Large subunits that lack L16 are defective in peptidyl transferase activity, peptidyl-tRNA hydrolysis activity, association with...; Region: Ribosomal_L16_L10e; cd01433 114615008916 23S rRNA interface [nucleotide binding]; other site 114615008917 5S rRNA interface [nucleotide binding]; other site 114615008918 putative antibiotic binding site [chemical binding]; other site 114615008919 L25 interface [polypeptide binding]; other site 114615008920 L27 interface [polypeptide binding]; other site 114615008921 Ribosomal L29 protein/HIP. L29 is a protein of the large ribosomal Subunit. A homolog, called heparin/heparan sulfate interacting protein (HIP), has also been identified in mammals. L29 is located on the surface of the large ribosomal subunit, where it...; Region: Ribosomal_L29_HIP; cd00427 114615008922 putative translocon interaction site; other site 114615008923 signal recognition particle (SRP54) interaction site; other site 114615008924 L23 interface [polypeptide binding]; other site 114615008925 trigger factor interaction site; other site 114615008926 23S rRNA interface [nucleotide binding]; other site 114615008927 30S ribosomal protein S17; Reviewed; Region: rpsQ; PRK05610 114615008928 50S ribosomal protein L14; Validated; Region: rplN; PRK05483 114615008929 50S ribosomal protein L24; Reviewed; Region: rplX; PRK00004 114615008930 KOW motif of Ribosomal Protein L26; Region: KOW_RPL26; cd06089 114615008931 RNA binding site [nucleotide binding]; other site 114615008932 50S ribosomal protein L5; Validated; Region: rplE; PRK00010 114615008933 Ribosomal protein L5; Region: Ribosomal_L5; pfam00281 114615008934 ribosomal L5P family C-terminus; Region: Ribosomal_L5_C; pfam00673 114615008935 30S ribosomal protein S14; Reviewed; Region: rpsN; PRK08881 114615008936 30S ribosomal protein S8; Validated; Region: rpsH; PRK00136 114615008937 50S ribosomal protein L6; Validated; Region: rplF; PRK05498 114615008938 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 114615008939 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 114615008940 Ribosomal L18/L5e: L18 (L5e) is a ribosomal protein found in the central protuberance (CP) of the large subunit. L18 binds 5S rRNA and induces a conformational change that stimulates the binding of L5 to 5S rRNA. Association of 5S rRNA with 23S rRNA...; Region: Ribosomal_L18_L5e; cd00432 114615008941 5S rRNA interface [nucleotide binding]; other site 114615008942 23S rRNA interface [nucleotide binding]; other site 114615008943 L5 interface [polypeptide binding]; other site 114615008944 30S ribosomal protein S5; Validated; Region: rpsE; PRK00550 114615008945 Ribosomal protein S5, N-terminal domain; Region: Ribosomal_S5; pfam00333 114615008946 Ribosomal protein S5, C-terminal domain; Region: Ribosomal_S5_C; pfam03719 114615008947 Ribosomal protein L30, which is found in eukaryotes and prokaryotes but not in archaea, is one of the smallest ribosomal proteins with a molecular mass of about 7kDa. L30 binds the 23SrRNA as well as the 5S rRNA and is one of five ribosomal proteins that...; Region: Ribosomal_L30; cd01658 114615008948 23S rRNA binding site [nucleotide binding]; other site 114615008949 50S ribosomal protein L15; Reviewed; Region: rplO; PRK05592 114615008950 preprotein translocase subunit SecY; Reviewed; Region: secY; PRK09204 114615008951 SecY translocase; Region: SecY; pfam00344 114615008952 adenylate kinase; Reviewed; Region: adk; PRK00279 114615008953 Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for...; Region: ADK; cd01428 114615008954 AMP-binding site [chemical binding]; other site 114615008955 ATP-AMP (Ap5A)-binding site [chemical binding]; other site 114615008956 Ribosomal protein S13 [Translation, ribosomal structure and biogenesis]; Region: RpsM; COG0099 114615008957 30S ribosomal protein S13; Region: bact_S13; TIGR03631 114615008958 30S ribosomal protein S11; Validated; Region: PRK05309 114615008959 DNA-directed RNA polymerase subunit alpha; Provisional; Region: PRK05182 114615008960 N-terminal domain of the Alpha subunit of Bacterial RNA polymerase; Region: RNAP_alpha_NTD; cd06928 114615008961 alphaNTD - beta interaction site [polypeptide binding]; other site 114615008962 alphaNTD homodimer interface [polypeptide binding]; other site 114615008963 alphaNTD - beta' interaction site [polypeptide binding]; other site 114615008964 Bacterial RNA polymerase, alpha chain C terminal domain; Region: RNA_pol_A_CTD; pfam03118 114615008965 50S ribosomal protein L17; Validated; Region: rplQ; PRK05591 114615008966 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: FabG; COG1028 114615008967 classical (c) SDRs; Region: SDR_c; cd05233 114615008968 NAD(P) binding site [chemical binding]; other site 114615008969 active site 114615008970 Protein of unknown function (DUF1330); Region: DUF1330; cl02288 114615008971 ClC chloride channel family. These protein sequences, closely related to the ClC Eric family, are putative halogen ion (Cl-, Br- and I-) transport proteins found in eubacteria. They belong to the ClC superfamily of chloride ion channels, which share a...; Region: EriC_like; cd01034 114615008972 Chloride channel protein EriC [Inorganic ion transport and metabolism]; Region: EriC; COG0038 114615008973 putative ion selectivity filter; other site 114615008974 putative pore gating glutamate residue; other site 114615008975 putative H+/Cl- coupling transport residue; other site 114615008976 NMT1/THI5 like; Region: NMT1; pfam09084 114615008977 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 114615008978 substrate binding pocket [chemical binding]; other site 114615008979 membrane-bound complex binding site; other site 114615008980 hinge residues; other site 114615008981 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 114615008982 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 114615008983 dimer interface [polypeptide binding]; other site 114615008984 conserved gate region; other site 114615008985 putative PBP binding loops; other site 114615008986 ABC-ATPase subunit interface; other site 114615008987 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 114615008988 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 114615008989 Walker A/P-loop; other site 114615008990 ATP binding site [chemical binding]; other site 114615008991 Q-loop/lid; other site 114615008992 ABC transporter signature motif; other site 114615008993 Walker B; other site 114615008994 D-loop; other site 114615008995 H-loop/switch region; other site 114615008996 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 114615008997 Cytosine deaminase and related metal-dependent hydrolases [Nucleotide transport and metabolism / General function prediction only]; Region: SsnA; COG0402 114615008998 active site 114615008999 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 114615009000 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 114615009001 NAD(P) binding site [chemical binding]; other site 114615009002 active site 114615009003 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK07231 114615009004 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 114615009005 NAD(P) binding site [chemical binding]; other site 114615009006 active site 114615009007 dihydroxy-acid dehydratase; Provisional; Region: PRK13017 114615009008 Transcriptional regulators [Transcription]; Region: PurR; COG1609 114615009009 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 114615009010 DNA binding site [nucleotide binding] 114615009011 domain linker motif; other site 114615009012 Ligand-binding domain of DNA transcription repressor GntR specific for gluconate, a member of the LacI-GalR family of bacterial transcription regulators; Region: PBP1_GntR; cd01575 114615009013 putative dimerization interface [polypeptide binding]; other site 114615009014 putative ligand binding site [chemical binding]; other site 114615009015 glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650 114615009016 The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301 114615009017 Walker A/P-loop; other site 114615009018 ATP binding site [chemical binding]; other site 114615009019 Q-loop/lid; other site 114615009020 ABC transporter signature motif; other site 114615009021 Walker B; other site 114615009022 D-loop; other site 114615009023 H-loop/switch region; other site 114615009024 TOBE domain; Region: TOBE_2; pfam08402 114615009025 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 114615009026 Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416 114615009027 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 114615009028 dimer interface [polypeptide binding]; other site 114615009029 conserved gate region; other site 114615009030 putative PBP binding loops; other site 114615009031 ABC-ATPase subunit interface; other site 114615009032 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 114615009033 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 114615009034 dimer interface [polypeptide binding]; other site 114615009035 conserved gate region; other site 114615009036 putative PBP binding loops; other site 114615009037 ABC-ATPase subunit interface; other site 114615009038 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 114615009039 Escherichia coli Gne (a nucleoside-diphosphate-sugar 4-epimerase)-like, extended (e) SDRs; Region: Gne_like_SDR_e; cd05238 114615009040 putative NAD(P) binding site [chemical binding]; other site 114615009041 active site 114615009042 putative substrate binding site [chemical binding]; other site 114615009043 acetyl-CoA acetyltransferase; Provisional; Region: PRK07516 114615009044 Thiolase domain associated with sterol carrier protein (SCP)-x isoform and related proteins; SCP-2 has multiple roles in intracellular lipid circulation and metabolism. The N-terminal presequence in the SCP-x isoform represents a peroxisomal...; Region: SCP-x_thiolase; cd00829 114615009045 active site 114615009046 ATP-dependent protease La (LON) domain; Region: LON; pfam02190 114615009047 Found in ATP-dependent protease La (LON); Region: LON; smart00464 114615009048 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 114615009049 DinB family; Region: DinB; cl17821 114615009050 DinB superfamily; Region: DinB_2; pfam12867 114615009051 Catalase-like heme-binding proteins similar to the uncharacterized y4iL; Region: y4iL_like; cd08152 114615009052 putative heme binding pocket [chemical binding]; other site 114615009053 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 114615009054 DNA binding site [nucleotide binding] 114615009055 AAA ATPase domain; Region: AAA_16; pfam13191 114615009056 AAA domain; Region: AAA_22; pfam13401 114615009057 Uncharacterized conserved protein [Function unknown]; Region: COG3791 114615009058 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 114615009059 CoA-transferase family III; Region: CoA_transf_3; pfam02515 114615009060 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 114615009061 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 114615009062 active site 114615009063 thiolase; Provisional; Region: PRK06158 114615009064 Thiolase domain associated with sterol carrier protein (SCP)-x isoform and related proteins; SCP-2 has multiple roles in intracellular lipid circulation and metabolism. The N-terminal presequence in the SCP-x isoform represents a peroxisomal...; Region: SCP-x_thiolase; cd00829 114615009065 active site 114615009066 Rubredoxin-like zinc ribbon domain (DUF35_N); Region: DUF35_N; pfam12172 114615009067 DUF35 OB-fold domain; Region: DUF35; pfam01796 114615009068 glutaminase A; Region: Gln_ase; TIGR03814 114615009069 Glutaminase [Amino acid transport and metabolism]; Region: GlsA; COG2066 114615009070 Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659 114615009071 Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function; Region: STAS_SulP_like_sulfate_transporter; cd07042 114615009072 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 114615009073 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 114615009074 ligand binding site [chemical binding]; other site 114615009075 flexible hinge region; other site 114615009076 Transcriptional regulator [Transcription]; Region: IclR; COG1414 114615009077 IclR helix-turn-helix domain; Region: HTH_IclR; pfam09339 114615009078 Bacterial transcriptional regulator; Region: IclR; pfam01614 114615009079 Acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta) [Lipid metabolism]; Region: COG4799 114615009080 malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682 114615009081 Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; cl17345 114615009082 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 114615009083 Major Facilitator Superfamily; Region: MFS_1; pfam07690 114615009084 putative substrate translocation pore; other site 114615009085 acetyl-CoA acetyltransferase; Provisional; Region: PRK06954 114615009086 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 114615009087 dimer interface [polypeptide binding]; other site 114615009088 active site 114615009089 Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024 114615009090 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 114615009091 substrate binding site [chemical binding]; other site 114615009092 oxyanion hole (OAH) forming residues; other site 114615009093 trimer interface [polypeptide binding]; other site 114615009094 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 114615009095 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 114615009096 Methylmalonate semialdehyde dehydrogenase and ALDH family members 6A1 and 6B2; Region: ALDH_F6_MMSDH; cd07085 114615009097 methylmalonic acid semialdehyde dehydrogenase; Region: MMSDH; TIGR01722 114615009098 tetrameric interface [polypeptide binding]; other site 114615009099 NAD binding site [chemical binding]; other site 114615009100 catalytic residues [active] 114615009101 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 114615009102 Isobutyryl-CoA dehydrogenase; Region: IBD; cd01162 114615009103 substrate binding pocket [chemical binding]; other site 114615009104 FAD binding site [chemical binding]; other site 114615009105 catalytic base [active] 114615009106 3-hydroxyisobutyryl-CoA hydrolase; Provisional; Region: PRK05617 114615009107 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 114615009108 substrate binding site [chemical binding]; other site 114615009109 oxyanion hole (OAH) forming residues; other site 114615009110 trimer interface [polypeptide binding]; other site 114615009111 2-enoyl-CoA Hydratase C-terminal region; Region: ECH_C; pfam13766 114615009112 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 114615009113 3-hydroxyisobutyrate dehydrogenase; Region: HIBADH; TIGR01692 114615009114 Acyl-coenzyme A synthetases/AMP-(fatty) acid ligases [Lipid metabolism]; Region: Acs; COG0365 114615009115 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 114615009116 acyl-activating enzyme (AAE) consensus motif; other site 114615009117 AMP binding site [chemical binding]; other site 114615009118 active site 114615009119 CoA binding site [chemical binding]; other site 114615009120 NodN (nodulation factor N) contains a single hot dog fold similar to those of the peroxisomal Hydratase-Dehydrogenase-Epimerase (HDE) protein, and the fatty acid synthase beta subunit. Rhizobium and related species form nodules on the roots of their...; Region: NodN; cd03450 114615009121 putative active site [active] 114615009122 putative catalytic site [active] 114615009123 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 114615009124 (3R)-hydroxyacyl-CoA dehydrogenase-like, classical(c)-like SDRs; Region: hydroxyacyl-CoA-like_DH_SDR_c-like; cd05353 114615009125 NAD binding site [chemical binding]; other site 114615009126 homodimer interface [polypeptide binding]; other site 114615009127 active site 114615009128 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 114615009129 uncharacterized flavoprotein, PP_4765 family; Region: flavo_PP4765; TIGR03862 114615009130 Predicted amino acid aldolase or racemase [Amino acid transport and metabolism]; Region: COG3616 114615009131 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes, Low Specificity D-Threonine Aldolase-like; Region: PLPDE_III_LS_D-TA_like; cd06820 114615009132 dimer interface [polypeptide binding]; other site 114615009133 active site 114615009134 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 114615009135 substrate binding site [chemical binding]; other site 114615009136 catalytic residue [active] 114615009137 ABC transporter ATPase component; Reviewed; Region: PRK11147 114615009138 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 114615009139 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 114615009140 hypothetical protein; Validated; Region: PRK00124 114615009141 Aerobic-type carbon monoxide dehydrogenase, large subunit CoxL/CutL homologs [Energy production and conversion]; Region: CoxL; COG1529 114615009142 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; smart01008 114615009143 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 114615009144 exopolyphosphatase; Region: exo_poly_only; TIGR03706 114615009145 Ppx/GppA phosphatase family; Region: Ppx-GppA; pfam02541 114615009146 23S rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: FtsJ; COG0293 114615009147 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 114615009148 S-adenosylmethionine binding site [chemical binding]; other site 114615009149 Protein of unknown function (DUF3551); Region: DUF3551; pfam12071 114615009150 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3181 114615009151 Tripartite tricarboxylate transporter TctB family; Region: TctB; pfam07331 114615009152 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3333 114615009153 Highly conserved protein containing a thioredoxin domain [Posttranslational modification, protein turnover, chaperones]; Region: COG1331 114615009154 Protein of unknown function (DUF1003); Region: DUF1003; pfam06210 114615009155 Protein of unknown function (DUF904); Region: DUF904; pfam06005 114615009156 Aerobic-type carbon monoxide dehydrogenase, large subunit CoxL/CutL homologs [Energy production and conversion]; Region: CoxL; COG1529 114615009157 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 114615009158 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; smart01008 114615009159 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 114615009160 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 114615009161 Aerobic-type carbon monoxide dehydrogenase, small subunit CoxS/CutS homologs [Energy production and conversion]; Region: CoxS; COG2080 114615009162 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 114615009163 catalytic loop [active] 114615009164 iron binding site [ion binding]; other site 114615009165 [2Fe-2S] binding domain; Region: Fer2_2; pfam01799 114615009166 Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010 114615009167 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 114615009168 putative transporter; Provisional; Region: PRK10504 114615009169 putative substrate translocation pore; other site 114615009170 inosine 5'-monophosphate dehydrogenase; Reviewed; Region: PRK05567 114615009171 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 114615009172 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in the inosine 5' monophosphate dehydrogenase (IMPDH) protein. IMPDH is an essential enzyme that catalyzes the first step unique to GTP synthesis, playing a...; Region: CBS_pair_IMPDH; cd04601 114615009173 IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381 114615009174 active site 114615009175 Putative NADP-dependent oxidoreductases [General function prediction only]; Region: COG2130 114615009176 Prostaglandin dehydrogenases; Region: PGDH; cd05288 114615009177 NAD(P) binding site [chemical binding]; other site 114615009178 substrate binding site [chemical binding]; other site 114615009179 dimer interface [polypeptide binding]; other site 114615009180 MAPEG family; Region: MAPEG; cl09190 114615009181 tRNA and rRNA cytosine-C5-methylases [Translation, ribosomal structure and biogenesis]; Region: Sun; COG0144 114615009182 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 114615009183 GMP synthase; Reviewed; Region: guaA; PRK00074 114615009184 Type 1 glutamine amidotransferase (GATase1) domain found in GMP synthetase; Region: GATase1_GMP_Synthase; cd01742 114615009185 AMP/PPi binding site [chemical binding]; other site 114615009186 candidate oxyanion hole; other site 114615009187 catalytic triad [active] 114615009188 potential glutamine specificity residues [chemical binding]; other site 114615009189 The C-terminal domain of GMP synthetase. It contains two subdomains; the ATP pyrophosphatase domain which closes to the N-termial and the dimerization domain at C-terminal end. The ATP-PPase is a twisted, five-stranded parallel beta-sheet sandwiched...; Region: GMP_synthase_C; cd01997 114615009190 ATP Binding subdomain [chemical binding]; other site 114615009191 Ligand Binding sites [chemical binding]; other site 114615009192 Dimerization subdomain; other site 114615009193 YcfA-like protein; Region: YcfA; pfam07927 114615009194 putative inner membrane protein; Provisional; Region: PRK11099 114615009195 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 114615009196 dimerization interface [polypeptide binding]; other site 114615009197 putative DNA binding site [nucleotide binding]; other site 114615009198 putative Zn2+ binding site [ion binding]; other site 114615009199 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 114615009200 Cytochrome c biogenesis protein [Posttranslational modification, protein turnover, chaperones]; Region: CcdA; COG0785 114615009201 Cytochrome C biogenesis protein transmembrane region; Region: DsbD; pfam02683 114615009202 SoxW family; SoxW is a bacterial periplasmic TRX, containing a redox active CXXC motif, encoded by a genetic locus (sox operon) involved in thiosulfate oxidation. Sulfur bacteria oxidize sulfur compounds to provide reducing equivalents for carbon dioxide...; Region: SoxW; cd02951 114615009203 catalytic residues [active] 114615009204 Cytochrome c; Region: Cytochrom_C; pfam00034 114615009205 sulfur oxidation protein SoxY; Provisional; Region: PRK07474 114615009206 Sulfur oxidation protein SoxY; Region: SoxY; pfam13501 114615009207 Sulphur oxidation protein SoxZ; Region: SoxZ; pfam08770 114615009208 Cytochrome c [Energy production and conversion]; Region: COG3258 114615009209 Cytochrome c [Energy production and conversion]; Region: COG3258 114615009210 5'-nucleotidase/2',3'-cyclic phosphodiesterase and related esterases [Nucleotide transport and metabolism]; Region: UshA; COG0737 114615009211 Thermus thermophilus SoxB and related proteins, N-terminal metallophosphatase domain; Region: MPP_SoxB_N; cd07411 114615009212 active site 114615009213 metal binding site [ion binding]; metal-binding site 114615009214 5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872 114615009215 bacterial SoxC is a member of the sulfite oxidase (SO) family of molybdopterin binding domains. SoxC is involved in oxidation of sulfur compounds during chemolithothrophic growth. Together with SoxD, a small c-type heme containing subunit, it forms a...; Region: bact_SoxC_Moco; cd02113 114615009216 Moco binding site; other site 114615009217 metal coordination site [ion binding]; other site 114615009218 dimerization interface [polypeptide binding]; other site 114615009219 Cytochrome c; Region: Cytochrom_C; pfam00034 114615009220 DsrE/DsrF-like family; Region: DrsE; cl00672 114615009221 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 114615009222 DsrE/DsrF-like family; Region: DrsE; cl00672 114615009223 Lyase class I_like superfamily: contains the lyase class I family, histidine ammonia-lyase and phenylalanine ammonia-lyase, which catalyze similar beta-elimination reactions; Region: Lyase_I_like; cl00013 114615009224 putative inner membrane protein; Provisional; Region: PRK11099 114615009225 Sulphur transport; Region: Sulf_transp; pfam04143 114615009226 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 114615009227 active site residue [active] 114615009228 DsbA family, Com1-like subfamily; composed of proteins similar to Com1, a 27-kDa outer membrane-associated immunoreactive protein originally found in both acute and chronic disease strains of the pathogenic bacteria Coxiella burnetti. It contains a CXXC...; Region: DsbA_Com1_like; cd03023 114615009229 DSBA-like thioredoxin domain; Region: DSBA; pfam01323 114615009230 catalytic residues [active] 114615009231 Disulphide bond corrector protein DsbC; Region: DsbC; cl15830 114615009232 Cytochrome C biogenesis protein transmembrane region; Region: DsbD; cl15788 114615009233 DsbD gamma family; DsbD gamma is the C-terminal periplasmic domain of the bacterial protein DsbD. It contains a CXXC motif in a TRX fold and shuttles the reducing potential from the membrane domain (DsbD beta) to the N-terminal periplasmic domain (DsbD...; Region: DsbDgamma; cd02953 114615009234 DsbD alpha interface [polypeptide binding]; other site 114615009235 catalytic residues [active] 114615009236 Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491 114615009237 Protein of unknown function (DUF2892); Region: DUF2892; pfam11127 114615009238 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 114615009239 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 114615009240 ligand binding site [chemical binding]; other site 114615009241 flexible hinge region; other site 114615009242 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 114615009243 putative switch regulator; other site 114615009244 non-specific DNA interactions [nucleotide binding]; other site 114615009245 DNA binding site [nucleotide binding] 114615009246 sequence specific DNA binding site [nucleotide binding]; other site 114615009247 putative cAMP binding site [chemical binding]; other site 114615009248 Uncharacterized homolog of gamma-carboxymuconolactone decarboxylase subunit [Function unknown]; Region: COG0599 114615009249 Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841 114615009250 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 114615009251 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 114615009252 HlyD family secretion protein; Region: HlyD_3; pfam13437 114615009253 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 114615009254 dimerization interface [polypeptide binding]; other site 114615009255 putative DNA binding site [nucleotide binding]; other site 114615009256 putative Zn2+ binding site [ion binding]; other site 114615009257 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_2; pfam07992 114615009258 thioredoxin 2; Provisional; Region: PRK10996 114615009259 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 114615009260 catalytic residues [active] 114615009261 Protein of unknown function (DUF2892); Region: DUF2892; pfam11127 114615009262 cytochrome c oxidase accessory protein FixG; Region: ccoG_rdxA_fixG; TIGR02745 114615009263 4Fe-4S binding domain; Region: Fer4_5; pfam12801 114615009264 Ubp3 associated protein Bre5; Region: Bre5; pfam11614 114615009265 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 114615009266 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 114615009267 Walker A motif; other site 114615009268 ATP binding site [chemical binding]; other site 114615009269 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189 114615009270 Walker B motif; other site 114615009271 arginine finger; other site 114615009272 Helix-turn-helix domain; Region: HTH_36; pfam13730 114615009273 Helix-turn-helix domain; Region: HTH_17; pfam12728 114615009274 Bacteriophage P4 integrase. P4-like integrases are found in temperate bacteriophages, integrative plasmids, pathogenicity and symbiosis islands, and other mobile genetic elements. They share the same fold in their catalytic domain and the overall...; Region: INT_P4; cd00801 114615009275 active site 114615009276 Int/Topo IB signature motif; other site 114615009277 DNA photolyase; Region: DNA_photolyase; pfam00875 114615009278 FAD binding domain of DNA photolyase; Region: FAD_binding_7; pfam03441 114615009279 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054 114615009280 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 114615009281 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 114615009282 dimer interface [polypeptide binding]; other site 114615009283 putative CheW interface [polypeptide binding]; other site 114615009284 DctM-like transporters; Region: DctM; pfam06808 114615009285 TRAP-type C4-dicarboxylate transport system, large permease component [Carbohydrate transport and metabolism]; Region: DctQ; cl17274 114615009286 Tripartite ATP-independent periplasmic transporters, DctQ component; Region: DctQ; pfam04290 114615009287 TRAP-type C4-dicarboxylate transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: DctP; COG1638 114615009288 Bacterial extracellular solute-binding protein, family 7; Region: SBP_bac_7; cl15441 114615009289 N-methylhydantoinase B/acetone carboxylase, alpha subunit [Amino acid transport and metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: HyuB; COG0146 114615009290 Hydantoinase B/oxoprolinase; Region: Hydantoinase_B; pfam02538 114615009291 N-methylhydantoinase A/acetone carboxylase, beta subunit [Amino acid transport and metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: HyuA; COG0145 114615009292 Hydantoinase/oxoprolinase N-terminal region; Region: Hydant_A_N; pfam05378 114615009293 Hydantoinase/oxoprolinase; Region: Hydantoinase_A; pfam01968 114615009294 Protein of unknown function (DUF1428); Region: DUF1428; pfam07237 114615009295 Superfamily II DNA and RNA helicases [DNA replication, recombination, and repair / Transcription / Translation, ribosomal structure and biogenesis]; Region: SrmB; COG0513 114615009296 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 114615009297 ATP binding site [chemical binding]; other site 114615009298 putative Mg++ binding site [ion binding]; other site 114615009299 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 114615009300 nucleotide binding region [chemical binding]; other site 114615009301 ATP-binding site [chemical binding]; other site 114615009302 RNA recognition motif in the DbpA subfamily of prokaryotic DEAD-box rRNA helicases; Region: RRM_DbpA; cd12252 114615009303 RNA binding site [nucleotide binding]; other site 114615009304 Predicted membrane protein (DUF2177); Region: DUF2177; pfam09945 114615009305 Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450 114615009306 Peroxiredoxin (PRX) family, 1-cys PRX subfamily; composed of PRXs containing only one conserved cysteine, which serves as the peroxidatic cysteine. They are homodimeric thiol-specific antioxidant (TSA) proteins that confer a protective role in cells by...; Region: PRX_1cys; cd03016 114615009307 dimer interface [polypeptide binding]; other site 114615009308 decamer (pentamer of dimers) interface [polypeptide binding]; other site 114615009309 catalytic triad [active] 114615009310 Sulfatase; Region: Sulfatase; cl17466 114615009311 Type I phosphodiesterase / nucleotide pyrophosphatase; Region: Phosphodiest; pfam01663 114615009312 YciF bacterial stress response protein, ferritin-like iron-binding domain; Region: YciF; cd07909 114615009313 dimerization interface [polypeptide binding]; other site 114615009314 metal binding site [ion binding]; metal-binding site 114615009315 Na+/H+ antiporter NhaD and related arsenite permeases [Inorganic ion transport and metabolism]; Region: ArsB; COG1055 114615009316 Anion permease ArsB. These permeases have been shown to export arsenate and antimonite in eubacteria and archaea. A typical ArsB permease contains 8-13 transmembrane helices and can function either independently as a chemiosmotic transporter or as a...; Region: ArsB_permease; cd01118 114615009317 transmembrane helices; other site 114615009318 Major Facilitator Superfamily; Region: MFS_1; pfam07690 114615009319 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 114615009320 Aminomethyltransferase folate-binding domain; Region: GCV_T; pfam01571 114615009321 Replication protein A, class 2b aminoacyl-tRNA synthetases, and related proteins with oligonucleotide/oligosaccharide (OB) fold; Region: RPA_2b-aaRSs_OBF_like; cl09930 114615009322 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204 114615009323 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 114615009324 active site 114615009325 phosphorylation site [posttranslational modification] 114615009326 intermolecular recognition site; other site 114615009327 dimerization interface [polypeptide binding]; other site 114615009328 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 114615009329 Walker A motif; other site 114615009330 ATP binding site [chemical binding]; other site 114615009331 Walker B motif; other site 114615009332 arginine finger; other site 114615009333 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 114615009334 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 114615009335 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 114615009336 dimer interface [polypeptide binding]; other site 114615009337 phosphorylation site [posttranslational modification] 114615009338 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 114615009339 ATP binding site [chemical binding]; other site 114615009340 Mg2+ binding site [ion binding]; other site 114615009341 G-X-G motif; other site 114615009342 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 114615009343 PAS fold; Region: PAS_3; pfam08447 114615009344 putative active site [active] 114615009345 heme pocket [chemical binding]; other site 114615009346 PAS domain S-box; Region: sensory_box; TIGR00229 114615009347 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 114615009348 putative active site [active] 114615009349 heme pocket [chemical binding]; other site 114615009350 Signal transduction histidine kinase, nitrogen specific [Signal transduction mechanisms]; Region: NtrB; COG3852 114615009351 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 114615009352 putative active site [active] 114615009353 heme pocket [chemical binding]; other site 114615009354 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 114615009355 dimer interface [polypeptide binding]; other site 114615009356 phosphorylation site [posttranslational modification] 114615009357 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 114615009358 ATP binding site [chemical binding]; other site 114615009359 Mg2+ binding site [ion binding]; other site 114615009360 G-X-G motif; other site 114615009361 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 114615009362 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 114615009363 active site 114615009364 phosphorylation site [posttranslational modification] 114615009365 intermolecular recognition site; other site 114615009366 dimerization interface [polypeptide binding]; other site 114615009367 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4307 114615009368 Uncharacterized protein conserved in bacteria (DUF2248); Region: DUF2248; pfam10005 114615009369 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 114615009370 Acetyl/propionyl-CoA carboxylase, alpha subunit [Lipid metabolism]; Region: COG4770 114615009371 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 114615009372 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786 114615009373 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; pfam02785 114615009374 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 114615009375 carboxyltransferase (CT) interaction site; other site 114615009376 biotinylation site [posttranslational modification]; other site 114615009377 Phosphoenolpyruvate phosphomutase; Region: PEP_mutase; pfam13714 114615009378 Members of the ICL/PEPM enzyme family catalyze either P-C or C-C bond formation/cleavage. Known members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate hydrolase (OAH), isocitrate...; Region: ICL_PEPM; cd00377 114615009379 tetramer interface [polypeptide binding]; other site 114615009380 active site 114615009381 Mg2+/Mn2+ binding site [ion binding]; other site 114615009382 Acylphosphatase; Region: Acylphosphatase; cl00551 114615009383 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 114615009384 S-adenosylmethionine binding site [chemical binding]; other site 114615009385 Predicted transcriptional regulators [Transcription]; Region: COG1510 114615009386 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 114615009387 putative DNA binding site [nucleotide binding]; other site 114615009388 putative Zn2+ binding site [ion binding]; other site 114615009389 Domain of unknown function (DUF4166); Region: DUF4166; pfam13761 114615009390 atypical (a) SDRs, subgroup 8; Region: SDR_a8; cd05242 114615009391 Predicted nucleoside-diphosphate sugar epimerase [General function prediction only]; Region: COG1090 114615009392 putative NAD(P) binding site [chemical binding]; other site 114615009393 putative active site [active] 114615009394 DNA-binding transcriptional activator FeaR; Provisional; Region: PRK09685 114615009395 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 114615009396 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 114615009397 Transcriptional regulator [Transcription]; Region: LysR; COG0583 114615009398 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 114615009399 LysR substrate binding domain; Region: LysR_substrate; pfam03466 114615009400 Uncharacterized protein, 4-oxalocrotonate tautomerase homolog [General function prediction only]; Region: COG1942 114615009401 active site 1 [active] 114615009402 dimer interface [polypeptide binding]; other site 114615009403 hexamer interface [polypeptide binding]; other site 114615009404 active site 2 [active] 114615009405 lipoate-protein ligase B; Provisional; Region: PRK14341 114615009406 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 114615009407 active site 114615009408 DNA binding site [nucleotide binding] 114615009409 Int/Topo IB signature motif; other site 114615009410 Cytidine and deoxycytidylate deaminase zinc-binding region. The family contains cytidine deaminases, nucleoside deaminases, deoxycytidylate deaminases and riboflavin deaminases. Also included are the apoBec family of mRNA editing enzymes. All members...; Region: cytidine_deaminase-like; cl00269 114615009411 active site 114615009412 Zn binding site [ion binding]; other site 114615009413 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 114615009414 Major Facilitator Superfamily; Region: MFS_1; pfam07690 114615009415 putative substrate translocation pore; other site 114615009416 Protein of unknown function (DUF1398); Region: DUF1398; cl11576 114615009417 Periplasmic binding protein; Region: Peripla_BP_6; pfam13458 114615009418 Periplasmic solute-binding domain of active transport proteins that belong to the type I periplasmic binding fold protein family; Region: PBP1_SBP_like_1; cd06327 114615009419 putative ligand binding site [chemical binding]; other site 114615009420 Uncharacterized conserved protein [Function unknown]; Region: COG3391 114615009421 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 114615009422 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 114615009423 Bacterial transcriptional repressor; Region: TetR_C_6; pfam13977 114615009424 Protein of unknown function (DUF3313); Region: DUF3313; pfam11769 114615009425 Patatins and Phospholipases; Region: Patatin_and_cPLA2; cl11396 114615009426 active site 114615009427 nucleophile elbow; other site 114615009428 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: FabG; COG1028 114615009429 classical (c) SDRs; Region: SDR_c; cd05233 114615009430 NAD(P) binding site [chemical binding]; other site 114615009431 active site 114615009432 IclR helix-turn-helix domain; Region: HTH_IclR; cl17605 114615009433 Predicted transcriptional regulators [Transcription]; Region: COG1695 114615009434 Transcriptional regulator PadR-like family; Region: PadR; cl17335 114615009435 amidophosphoribosyltransferase; Provisional; Region: PRK09123 114615009436 Glutamine amidotransferases class-II (GN-AT)_GPAT- type. This domain is found at the N-terminus of glutamine phosphoribosylpyrophosphate (Prpp) amidotransferase (GPATase) . The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the...; Region: GPATase_N; cd00715 114615009437 active site 114615009438 tetramer interface [polypeptide binding]; other site 114615009439 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 114615009440 active site 114615009441 Uncharacterized membrane protein, required for colicin V production [General function prediction only]; Region: CvpA; COG1286 114615009442 Colicin V production protein; Region: Colicin_V; pfam02674 114615009443 DNA repair protein RadA; Provisional; Region: PRK11823 114615009444 Sms (bacterial radA) DNA repair protein. This protein is not related to archael radA any more than is to other RecA-like NTPases. Sms has a role in recombination and recombinational repair and is responsible for the stabilization or processing of...; Region: Sms; cd01121 114615009445 Walker A motif/ATP binding site; other site 114615009446 ATP binding site [chemical binding]; other site 114615009447 Walker B motif; other site 114615009448 Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541 114615009449 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 114615009450 DNA-binding transcriptional activator FeaR; Provisional; Region: PRK09685 114615009451 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 114615009452 methyl indole-3-acetate methyltransferase; Region: PLN02211; cl17657 114615009453 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 114615009454 Escherichia coli exonuclease III (ExoIII) and Neisseria meningitides NExo-like subfamily of the ExoIII family purinic/apyrimidinic (AP) endonucleases; Region: ExoIII-like_AP-endo; cd09086 114615009455 putative catalytic site [active] 114615009456 putative phosphate binding site [ion binding]; other site 114615009457 active site 114615009458 metal binding site A [ion binding]; metal-binding site 114615009459 DNA binding site [nucleotide binding] 114615009460 putative AP binding site [nucleotide binding]; other site 114615009461 putative metal binding site B [ion binding]; other site 114615009462 Cysteine rich repeat; Region: Cys_rich_FGFR; pfam00839 114615009463 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 114615009464 Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300 114615009465 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 114615009466 NAD(P) binding site [chemical binding]; other site 114615009467 active site 114615009468 Lipocalin-like domain; Region: Lipocalin_2; pfam08212 114615009469 Threonyl-tRNA synthetase (ThrRS) class II core catalytic domain. ThrRS is a homodimer. It is responsible for the attachment of threonine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ThrRS_core; cd00771 114615009470 active site 114615009471 dimer interface [polypeptide binding]; other site 114615009472 motif 1; other site 114615009473 motif 2; other site 114615009474 motif 3; other site 114615009475 HGTP anticodon binding domain, as found at the C-terminus of histidyl, glycyl, threonyl and prolyl tRNA synthetases, which are classified as a group of class II aminoacyl-tRNA synthetases (aaRS). In aaRSs, the anticodon binding domain is responsible for...; Region: HGTP_anticodon; cl00266 114615009476 anticodon binding site; other site 114615009477 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 114615009478 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 114615009479 Coenzyme A binding pocket [chemical binding]; other site 114615009480 Alanine racemase [Cell envelope biogenesis, outer membrane]; Region: Alr; COG0787 114615009481 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Alanine Racemase; Region: PLPDE_III_AR; cd00430 114615009482 active site 114615009483 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 114615009484 dimer interface [polypeptide binding]; other site 114615009485 substrate binding site [chemical binding]; other site 114615009486 catalytic residues [active] 114615009487 replicative DNA helicase; Provisional; Region: PRK09165 114615009488 DnaB-like helicase N terminal domain; Region: DnaB; pfam00772 114615009489 DnaB helicase C terminal domain. The hexameric helicase DnaB unwinds the DNA duplex at the chromosome replication fork. Although the mechanism by which DnaB both couples ATP hydrolysis to translocation along DNA and denatures the duplex is unknown, a...; Region: DnaB_C; cd00984 114615009490 Walker A motif; other site 114615009491 ATP binding site [chemical binding]; other site 114615009492 Walker B motif; other site 114615009493 DNA binding loops [nucleotide binding] 114615009494 Cyclopropane fatty acid synthase and related methyltransferases [Cell envelope biogenesis, outer membrane]; Region: Cfa; COG2230 114615009495 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 114615009496 S-adenosylmethionine binding site [chemical binding]; other site 114615009497 50S ribosomal protein L9; Reviewed; Region: rplI; PRK00137 114615009498 Ribosomal protein L9, N-terminal domain; Region: Ribosomal_L9_N; pfam01281 114615009499 Ribosomal protein L9, C-terminal domain; Region: Ribosomal_L9_C; pfam03948 114615009500 30S ribosomal protein S18; Reviewed; Region: rpsR; PRK00391 114615009501 30S ribosomal protein S6; Reviewed; Region: rpsF; PRK00453 114615009502 (acyl-carrier-protein) S-malonyltransferase [Lipid metabolism]; Region: FabD; COG0331 114615009503 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 114615009504 3-ketoacyl-(acyl-carrier-protein) reductase NodG; Reviewed; Region: PRK12936 114615009505 beta-Keto acyl carrier protein reductase (BKR), involved in Type II FAS, classical (c) SDRs; Region: BKR_SDR_c; cd05333 114615009506 NAD(P) binding site [chemical binding]; other site 114615009507 homotetramer interface [polypeptide binding]; other site 114615009508 homodimer interface [polypeptide binding]; other site 114615009509 active site 114615009510 acyl carrier protein; Provisional; Region: acpP; PRK00982 114615009511 3-oxoacyl-(acyl carrier protein) synthase II; Reviewed; Region: PRK07314 114615009512 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 114615009513 dimer interface [polypeptide binding]; other site 114615009514 active site 114615009515 YceG-like family; Region: YceG; pfam02618 114615009516 proteins similar to Escherichia coli yceG; Region: yceG_like; cd08010 114615009517 dimerization interface [polypeptide binding]; other site 114615009518 hypothetical protein; Provisional; Region: PRK11820 114615009519 YicC-like family, N-terminal region; Region: YicC_N; pfam03755 114615009520 Domain of unknown function (DUF1732); Region: DUF1732; pfam08340 114615009521 Guanylate kinase [Nucleotide transport and metabolism]; Region: Gmk; COG0194 114615009522 Guanosine monophosphate kinase (GMPK, EC 2.7.4.8), also known as guanylate kinase (GKase), catalyzes the reversible phosphoryl transfer from adenosine triphosphate (ATP) to guanosine monophosphate (GMP) to yield adenosine diphosphate (ADP) and guanosine...; Region: GMPK; cd00071 114615009523 catalytic site [active] 114615009524 G-X2-G-X-G-K; other site 114615009525 Caspase domain; Region: Peptidase_C14; pfam00656 114615009526 Domain of unknown function (DUF4189); Region: DUF4189; pfam13827 114615009527 Zn-dependent alcohol dehydrogenases [General function prediction only]; Region: AdhP; COG1064 114615009528 6-hydroxyhexanoate dehydrogenase; Region: 6_hydroxyhexanoate_dh_like; cd08240 114615009529 putative NAD(P) binding site [chemical binding]; other site 114615009530 catalytic Zn binding site [ion binding]; other site 114615009531 16S ribosomal RNA methyltransferase KsgA/Dim1 family protein; Reviewed; Region: ksgA; PRK00274 114615009532 Dimethyladenosine transferase (rRNA methylation) [Translation, ribosomal structure and biogenesis]; Region: KsgA; COG0030 114615009533 4-hydroxythreonine-4-phosphate dehydrogenase; Provisional; Region: pdxA; PRK05312 114615009534 4-hydroxythreonine-4-phosphate dehydrogenase; Validated; Region: pdxA; PRK03743 114615009535 SurA N-terminal domain; Region: SurA_N; pfam09312 114615009536 Organic solvent tolerance protein OstA [Cell envelope biogenesis, outer membrane]; Region: Imp; COG1452 114615009537 OstA-like protein; Region: OstA; cl00844 114615009538 Organic solvent tolerance protein; Region: OstA_C; pfam04453 114615009539 Predicted permeases [General function prediction only]; Region: COG0795 114615009540 Predicted permease YjgP/YjgQ family; Region: YjgP_YjgQ; pfam03739 114615009541 Predicted permeases [General function prediction only]; Region: COG0795 114615009542 Predicted permease YjgP/YjgQ family; Region: YjgP_YjgQ; pfam03739 114615009543 multifunctional aminopeptidase A; Provisional; Region: PRK00913 114615009544 Cytosol aminopeptidase family, N-terminal and catalytic domains. Family M17 contains zinc- and manganese-dependent exopeptidases ( EC 3.4.11.1), including leucine aminopeptidase. They catalyze removal of amino acids from the N-terminus of a protein and...; Region: Peptidase_M17; cd00433 114615009545 interface (dimer of trimers) [polypeptide binding]; other site 114615009546 Substrate-binding/catalytic site; other site 114615009547 Zn-binding sites [ion binding]; other site 114615009548 DNA polymerase III subunit chi; Validated; Region: PRK05728 114615009549 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 114615009550 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 114615009551 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 114615009552 ABC transporter; Region: ABC_tran_2; pfam12848 114615009553 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 114615009554 Nucleoside diphosphate kinase Group I (NDPk_I)-like: NDP kinase domains are present in a large family of structurally and functionally conserved proteins from bacteria to humans that generally catalyze the transfer of gamma-phosphates of a nucleoside...; Region: NDPk_I; cd04413 114615009555 active site 114615009556 multimer interface [polypeptide binding]; other site 114615009557 integral membrane protein, YjbE family; Region: R_switched_YjbE; TIGR03717 114615009558 Amino Acid Kinases (AAK) superfamily, catalytic domain; present in such enzymes like N-acetylglutamate kinase (NAGK), carbamate kinase (CK), aspartokinase (AK), glutamate-5-kinase (G5K) and UMP kinase (UMPK). The AAK superfamily includes kinases that...; Region: AAK; cl00452 114615009559 nucleotide binding site [chemical binding]; other site 114615009560 substrate binding site [chemical binding]; other site 114615009561 AAK_UMPK-MosAB: This CD includes the alpha and beta subunits of the Mo storage protein (MosA and MosB) which are related to uridine monophosphate kinase (UMPK) enzymes that catalyze the phosphorylation of UMP by ATP, yielding UDP, and playing a key role...; Region: AAK_UMPK-MosAB; cd04255 114615009562 putative nucleotide binding site [chemical binding]; other site 114615009563 putative substrate binding site [chemical binding]; other site 114615009564 exopolyphosphatase; Region: exo_poly_only; TIGR03706 114615009565 Ppx/GppA phosphatase family; Region: Ppx-GppA; pfam02541 114615009566 polyphosphate kinase; Provisional; Region: PRK05443 114615009567 Polyphosphate kinase N-terminal domain; Region: PP_kinase_N; pfam13089 114615009568 Polyphosphate kinase middle domain; Region: PP_kinase; pfam02503 114615009569 Catalytic C-terminal domain, first repeat, of Pseudomonas aeruginosa polyphosphate kinase 1 and similar proteins; Region: PLDc_PaPPK1_C1_like; cd09165 114615009570 putative domain interface [polypeptide binding]; other site 114615009571 putative active site [active] 114615009572 catalytic site [active] 114615009573 Catalytic C-terminal domain, second repeat, of Pseudomonas aeruginosa polyphosphate kinase 1 and similar proteins; Region: PLDc_PaPPK1_C2_like; cd09168 114615009574 putative domain interface [polypeptide binding]; other site 114615009575 putative active site [active] 114615009576 catalytic site [active] 114615009577 ATPase involved in DNA replication initiation [DNA replication, recombination, and repair]; Region: DnaA; COG0593 114615009578 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189 114615009579 CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; cl00453 114615009580 phosphoribosylaminoimidazole synthetase; Provisional; Region: PRK05385 114615009581 PurM (Aminoimidazole Ribonucleotide [AIR] synthetase), one of eleven enzymes required for purine biosynthesis, catalyzes the conversion of formylglycinamide ribonucleotide (FGAM) and ATP to AIR, ADP, and Pi, the fifth step in de novo purine biosynthesis; Region: PurM; cd02196 114615009582 dimerization interface [polypeptide binding]; other site 114615009583 putative ATP binding site [chemical binding]; other site 114615009584 phosphoribosylglycinamide formyltransferase; Reviewed; Region: purN; PRK05647 114615009585 Phosphoribosylglycinamide formyltransferase (GAR transformylase, GART); Region: FMT_core_GART; cd08645 114615009586 active site 114615009587 substrate binding site [chemical binding]; other site 114615009588 cosubstrate binding site; other site 114615009589 catalytic site [active] 114615009590 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 114615009591 DNA-binding site [nucleotide binding]; DNA binding site 114615009592 RNA-binding motif; other site 114615009593 Transcriptional regulator [Transcription]; Region: LysR; COG0583 114615009594 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 114615009595 LysR substrate binding domain; Region: LysR_substrate; pfam03466 114615009596 dimerization interface [polypeptide binding]; other site 114615009597 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 114615009598 Coenzyme A binding pocket [chemical binding]; other site 114615009599 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cl00220 114615009600 Isochorismatase family; Region: Isochorismatase; pfam00857 114615009601 catalytic triad [active] 114615009602 conserved cis-peptide bond; other site 114615009603 Ribonuclease D [Translation, ribosomal structure and biogenesis]; Region: Rnd; COG0349 114615009604 DEDDy 3'-5' exonuclease domain of Ribonuclease D and similar proteins; Region: RNaseD_exo; cd06142 114615009605 catalytic site [active] 114615009606 putative active site [active] 114615009607 putative substrate binding site [chemical binding]; other site 114615009608 HRDC domain; Region: HRDC; pfam00570 114615009609 hypothetical protein; Validated; Region: PRK00029 114615009610 Uncharacterized conserved protein [Function unknown]; Region: COG0397 114615009611 aspartyl-tRNA synthetase; Validated; Region: aspS; PRK00476 114615009612 EcAspRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli aspartyl-tRNA synthetase (AspRS), the human mitochondrial (mt) AspRS-2, the discriminating (D) Thermus thermophilus AspRS-1, and the nondiscriminating (ND)...; Region: EcAspRS_like_N; cd04317 114615009613 dimer interface [polypeptide binding]; other site 114615009614 anticodon binding site; other site 114615009615 Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of...; Region: AspRS_core; cd00777 114615009616 homodimer interface [polypeptide binding]; other site 114615009617 motif 1; other site 114615009618 active site 114615009619 motif 2; other site 114615009620 GAD domain; Region: GAD; pfam02938 114615009621 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 114615009622 active site 114615009623 motif 3; other site 114615009624 Lipoproteins [Cell envelope biogenesis, outer membrane]; Region: RlpA; COG0797 114615009625 Rare lipoprotein A (RlpA)-like double-psi beta-barrel; Region: DPBB_1; pfam03330 114615009626 Fatty acid hydroxylase superfamily; Region: FA_hydroxylase; cl01132 114615009627 Flp pilus assembly protein TadG [Intracellular trafficking and secretion]; Region: TadG; COG4961 114615009628 TadE-like protein; Region: TadE; pfam07811 114615009629 Flp pilus assembly protein TadG [Intracellular trafficking and secretion]; Region: TadG; COG4961 114615009630 bifunctional malic enzyme oxidoreductase/phosphotransacetylase; Reviewed; Region: PRK07232 114615009631 Malic enzyme, N-terminal domain; Region: malic; pfam00390 114615009632 NAD(P) binding domain of malic enzyme (ME), subgroup 2; Region: NAD_bind_2_malic_enz; cd05311 114615009633 putative NAD(P) binding site [chemical binding]; other site 114615009634 Phosphotransacetylase [Energy production and conversion]; Region: Pta; COG0280 114615009635 Predicted membrane protein [Function unknown]; Region: COG2259 114615009636 Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5; Region: DHFR; cl17426 114615009637 NADP+ binding site [chemical binding]; other site 114615009638 folate binding site [chemical binding]; other site 114615009639 Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726 114615009640 Catalytic NodB homology domain of rhizobial NodB-like proteins; Region: CE4_NodB_like_6s_7s; cd10917 114615009641 NodB motif; other site 114615009642 active site 114615009643 catalytic site [active] 114615009644 metal binding site [ion binding]; metal-binding site 114615009645 Glutathione (GSH) peroxidase family; tetrameric selenoenzymes that catalyze the reduction of a variety of hydroperoxides including lipid peroxidases, using GSH as a specific electron donor substrate. GSH peroxidase contains one selenocysteine residue per...; Region: GSH_Peroxidase; cd00340 114615009646 catalytic residues [active] 114615009647 dimer interface [polypeptide binding]; other site 114615009648 hypothetical protein; Provisional; Region: PRK06132 114615009649 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 114615009650 Uncharacterized protein conserved in bacteria [Function unknown]; Region: CreA; COG3045 114615009651 CreA protein; Region: CreA; pfam05981 114615009652 ABC-type protease/lipase transport system, ATPase and permease components [General function prediction only]; Region: ArpD; COG4618 114615009653 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 114615009654 ATP-binding cassette domain of PrtD, subfamily C; Region: ABCC_Protease_Secretion; cd03246 114615009655 Walker A/P-loop; other site 114615009656 ATP binding site [chemical binding]; other site 114615009657 Q-loop/lid; other site 114615009658 ABC transporter signature motif; other site 114615009659 Walker B; other site 114615009660 D-loop; other site 114615009661 H-loop/switch region; other site 114615009662 Ferredoxin [Energy production and conversion]; Region: Fdx; COG0633 114615009663 Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114 114615009664 cyclase homology domain; Region: CHD; cd07302 114615009665 nucleotidyl binding site; other site 114615009666 dimer interface [polypeptide binding]; other site 114615009667 metal binding site [ion binding]; metal-binding site 114615009668 type I secretion membrane fusion protein, HlyD family; Region: type_I_hlyD; TIGR01843 114615009669 HlyD family secretion protein; Region: HlyD_3; pfam13437 114615009670 acetylornithine deacetylase; Provisional; Region: PRK06837 114615009671 M20 Peptidases with similarity to acetylornithine deacetylases and succinyl-diaminopimelate desuccinylases; Region: M20_ArgE_DapE_like2; cd03895 114615009672 metal binding site [ion binding]; metal-binding site 114615009673 dimer interface [polypeptide binding]; other site 114615009674 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 114615009675 CoenzymeA binding site [chemical binding]; other site 114615009676 subunit interaction site [polypeptide binding]; other site 114615009677 PHB binding site; other site 114615009678 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 114615009679 Coenzyme A binding pocket [chemical binding]; other site 114615009680 Uncharacterized conserved protein [Function unknown]; Region: COG5482 114615009681 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 114615009682 dihydropteridine reductase (DHPR), classical (c) SDRs; Region: DHPR_SDR_c_like; cd05334 114615009683 NAD binding site [chemical binding]; other site 114615009684 homodimer interface [polypeptide binding]; other site 114615009685 active site 114615009686 SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cd00229 114615009687 active site 114615009688 catalytic triad [active] 114615009689 oxyanion hole [active] 114615009690 Tyrosine phosphatase family; Region: Y_phosphatase3; pfam13350 114615009691 Tyrosine phosphatase family C-terminal region; Region: Y_phosphatase3C; pfam13348 114615009692 Protein of unknown function (DUF2735); Region: DUF2735; pfam10931 114615009693 glutamine synthetase; Region: PLN02284 114615009694 Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951 114615009695 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 114615009696 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 114615009697 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 114615009698 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 114615009699 ABC transporter; Region: ABC_tran_2; pfam12848 114615009700 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 114615009701 Dienelactone hydrolase and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG0412 114615009702 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 114615009703 PAS fold; Region: PAS_4; pfam08448 114615009704 PAS fold; Region: PAS_4; pfam08448 114615009705 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 114615009706 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 114615009707 dimer interface [polypeptide binding]; other site 114615009708 phosphorylation site [posttranslational modification] 114615009709 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 114615009710 ATP binding site [chemical binding]; other site 114615009711 Mg2+ binding site [ion binding]; other site 114615009712 G-X-G motif; other site 114615009713 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 114615009714 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 114615009715 active site 114615009716 phosphorylation site [posttranslational modification] 114615009717 intermolecular recognition site; other site 114615009718 dimerization interface [polypeptide binding]; other site 114615009719 Protein of unknown function (DUF1810); Region: DUF1810; pfam08837 114615009720 Protein of unknown function (DUF2778); Region: DUF2778; pfam10908 114615009721 dimethyl sulfone monooxygenase SfnG; Region: LLM_DMSO2_sfnG; TIGR04021 114615009722 Alkanesulfonate monoxygenase is the monoxygenase of a two-component system that catalyzes the conversion of alkanesulfonates to the corresponding aldehyde and sulfite. Alkanesulfonate monoxygenase (SsuD) has an absolute requirement for reduced flavin...; Region: Alkanesulfonate_monoxygenase; cd01094 114615009723 active site 114615009724 dimer interface [polypeptide binding]; other site 114615009725 non-prolyl cis peptide bond; other site 114615009726 insertion regions; other site 114615009727 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411 114615009728 ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219 114615009729 Walker A/P-loop; other site 114615009730 ATP binding site [chemical binding]; other site 114615009731 Q-loop/lid; other site 114615009732 ABC transporter signature motif; other site 114615009733 Walker B; other site 114615009734 D-loop; other site 114615009735 H-loop/switch region; other site 114615009736 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 114615009737 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 114615009738 TM-ABC transporter signature motif; other site 114615009739 ABC-type branched-chain amino acid transport system, permease component [Amino acid transport and metabolism]; Region: LivM; COG4177 114615009740 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 114615009741 TM-ABC transporter signature motif; other site 114615009742 Type I periplasmic ligand-binding domain of uncharacterized ABC (ATPase Binding Cassette)-type active transport systems that are predicted to be involved in transport of amino acids, peptides, or inorganic ions; Region: PBP1_ABC_ligand_binding_like_1; cd06334 114615009743 Periplasmic binding protein; Region: Peripla_BP_6; pfam13458 114615009744 putative ligand binding site [chemical binding]; other site 114615009745 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410 114615009746 ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224 114615009747 Walker A/P-loop; other site 114615009748 ATP binding site [chemical binding]; other site 114615009749 Q-loop/lid; other site 114615009750 ABC transporter signature motif; other site 114615009751 Walker B; other site 114615009752 D-loop; other site 114615009753 H-loop/switch region; other site 114615009754 Predicted flavoprotein [General function prediction only]; Region: COG0431 114615009755 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 114615009756 DNA-binding transcriptional activator GcvA; Provisional; Region: PRK11139 114615009757 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 114615009758 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 114615009759 dimerization interface [polypeptide binding]; other site 114615009760 4-aminobutyrate aminotransferase; Provisional; Region: PRK07495 114615009761 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 114615009762 inhibitor-cofactor binding pocket; inhibition site 114615009763 pyridoxal 5'-phosphate binding site [chemical binding]; other site 114615009764 catalytic residue [active] 114615009765 acetylornithine deacetylase; Provisional; Region: PRK06837 114615009766 M20 Peptidases with similarity to acetylornithine deacetylases and succinyl-diaminopimelate desuccinylases; Region: M20_ArgE_DapE_like2; cd03895 114615009767 metal binding site [ion binding]; metal-binding site 114615009768 dimer interface [polypeptide binding]; other site 114615009769 Putative glycerate dehydrogenase and related proteins of the D-specific 2-hydroxy dehydrogenase family; Region: GDH_like_2; cd12164 114615009770 bifunctional glyoxylate/hydroxypyruvate reductase A; Provisional; Region: ghrA; PRK15469 114615009771 putative ligand binding site [chemical binding]; other site 114615009772 NAD binding site [chemical binding]; other site 114615009773 dimerization interface [polypeptide binding]; other site 114615009774 catalytic site [active] 114615009775 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; smart00471 114615009776 Zn2+ binding site [ion binding]; other site 114615009777 Mg2+ binding site [ion binding]; other site 114615009778 Predicted phosphatases [General function prediction only]; Region: Gph; COG0546 114615009779 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 114615009780 motif II; other site 114615009781 PAS domain S-box; Region: sensory_box; TIGR00229 114615009782 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 114615009783 putative active site [active] 114615009784 heme pocket [chemical binding]; other site 114615009785 PAS domain; Region: PAS_9; pfam13426 114615009786 Motif C-terminal to PAS motifs (likely to contribute to PAS structural domain); Region: PAC; smart00086 114615009787 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920 114615009788 HWE histidine kinase; Region: HWE_HK; smart00911 114615009789 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 114615009790 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 114615009791 ligand binding site [chemical binding]; other site 114615009792 flexible hinge region; other site 114615009793 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 114615009794 non-specific DNA interactions [nucleotide binding]; other site 114615009795 DNA binding site [nucleotide binding] 114615009796 sequence specific DNA binding site [nucleotide binding]; other site 114615009797 putative cAMP binding site [chemical binding]; other site 114615009798 HAMP domain; Region: HAMP; pfam00672 114615009799 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 114615009800 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 114615009801 dimer interface [polypeptide binding]; other site 114615009802 putative CheW interface [polypeptide binding]; other site 114615009803 Domain of unknown function (DUF4142); Region: DUF4142; pfam13628 114615009804 Protein of unknown function DUF72; Region: DUF72; pfam01904 114615009805 Glucose/sorbosone dehydrogenases [Carbohydrate transport and metabolism]; Region: COG2133 114615009806 Predicted membrane protein [Function unknown]; Region: COG4244 114615009807 Chlorite dismutase; Region: Chlor_dismutase; cl01280 114615009808 3-hydroxybutyryl-CoA dehydrogenase; Validated; Region: PRK05808 114615009809 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 114615009810 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 114615009811 Copper binding periplasmic protein CusF; Region: CusF_Ec; cl02363 114615009812 Uncharacterized protein conserved in bacteria (DUF2066); Region: DUF2066; pfam09839 114615009813 Uncharacterized protein with a bacterial SH3 domain homologue [Function unknown]; Region: COG4991 114615009814 Bacterial SH3 domain; Region: SH3_3; pfam08239 114615009815 Protein of unknown function (DUF3750); Region: DUF3750; pfam12570 114615009816 Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cd03467 114615009817 iron-sulfur cluster [ion binding]; other site 114615009818 [2Fe-2S] cluster binding site [ion binding]; other site 114615009819 Zinc ribbon domain; Region: CxxC_CxxC_SSSS; pfam09723 114615009820 Predicted ring-cleavage extradiol dioxygenase [General function prediction only]; Region: COG2514 114615009821 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_12; cd07255 114615009822 putative metal binding site [ion binding]; other site 114615009823 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 114615009824 active site 114615009825 Uncharacterized Zn-ribbon-containing protein involved in phosphonate metabolism [Inorganic ion transport and metabolism]; Region: PhnA; COG2824 114615009826 PhnA Zinc-Ribbon; Region: PhnA_Zn_Ribbon; pfam08274 114615009827 PhnA protein; Region: PhnA; pfam03831 114615009828 Uncharacterized protein conserved in bacteria (DUF2312); Region: DUF2312; pfam10073 114615009829 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 114615009830 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 114615009831 active site 114615009832 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 114615009833 N-acetyl-D-glucosamine binding site [chemical binding]; other site 114615009834 catalytic residue [active] 114615009835 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 114615009836 dimer interface [polypeptide binding]; other site 114615009837 putative CheW interface [polypeptide binding]; other site 114615009838 Uncharacterized protein conserved in bacteria (DUF2171); Region: DUF2171; pfam09939 114615009839 Uncharacterized conserved protein [Function unknown]; Region: COG5276 114615009840 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 114615009841 Cytochrome P450; Region: p450; cl12078 114615009842 Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr; Region: PTPc; cl00053 114615009843 active site 114615009844 catalytic residues [active] 114615009845 ribonucleotide-diphosphate reductase subunit alpha; Validated; Region: PRK07562 114615009846 Class II vitamin B12-dependent ribonucleotide reductase; Region: Ribonuc_red_2_N; pfam08471 114615009847 Ribonucleotide reductase and Pyruvate formate lyase; Region: RNR_PFL; cl09939 114615009848 Class II ribonucleotide reductase, dimeric form; Region: RNR_II_dimer; cd02888 114615009849 active site 114615009850 Ribonucleotide reductase and Pyruvate formate lyase; Region: RNR_PFL; cl09939 114615009851 TSCPD domain; Region: TSCPD; pfam12637 114615009852 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 114615009853 EamA-like transporter family; Region: EamA; pfam00892 114615009854 EamA-like transporter family; Region: EamA; pfam00892 114615009855 CHASE3 domain; Region: CHASE3; pfam05227 114615009856 Signal transduction histidine kinase, nitrogen specific [Signal transduction mechanisms]; Region: NtrB; COG3852 114615009857 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 114615009858 putative active site [active] 114615009859 heme pocket [chemical binding]; other site 114615009860 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 114615009861 dimer interface [polypeptide binding]; other site 114615009862 phosphorylation site [posttranslational modification] 114615009863 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 114615009864 ATP binding site [chemical binding]; other site 114615009865 G-X-G motif; other site 114615009866 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 114615009867 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 114615009868 active site 114615009869 phosphorylation site [posttranslational modification] 114615009870 intermolecular recognition site; other site 114615009871 dimerization interface [polypeptide binding]; other site 114615009872 CHASE3 domain; Region: CHASE3; pfam05227 114615009873 Signal transduction histidine kinase, nitrogen specific [Signal transduction mechanisms]; Region: NtrB; COG3852 114615009874 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 114615009875 putative active site [active] 114615009876 heme pocket [chemical binding]; other site 114615009877 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 114615009878 dimer interface [polypeptide binding]; other site 114615009879 phosphorylation site [posttranslational modification] 114615009880 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 114615009881 ATP binding site [chemical binding]; other site 114615009882 Mg2+ binding site [ion binding]; other site 114615009883 G-X-G motif; other site 114615009884 Response regulator receiver domain; Region: Response_reg; pfam00072 114615009885 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 114615009886 active site 114615009887 phosphorylation site [posttranslational modification] 114615009888 intermolecular recognition site; other site 114615009889 dimerization interface [polypeptide binding]; other site 114615009890 BA14K-like protein; Region: BA14K; pfam07886 114615009891 NADH dehydrogenase; Validated; Region: PRK08183 114615009892 Type 1 glutamine amidotransferase (GATase1)-like domain found in a subgroup of proteins similar to PfpI from Pyrococcus furiosus; Region: GATase1_PfpI_2; cd03139 114615009893 Putative intracellular protease/amidase [General function prediction only]; Region: ThiJ; COG0693 114615009894 conserved cys residue [active] 114615009895 Transcriptional regulator containing an amidase domain and an AraC-type DNA-binding HTH domain [Transcription]; Region: COG4977 114615009896 AraC transcriptional regulators having a Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GATase1_AraC_1; cd03137 114615009897 conserved cys residue [active] 114615009898 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 114615009899 Peptidase M14 Succinylglutamate desuccinylase (ASTE)/aspartoacylase (ASPA)-like; uncharacterized subgroup; Region: M14_ASTE_ASPA_like_6; cd06256 114615009900 putative active site [active] 114615009901 Zn binding site [ion binding]; other site 114615009902 ATP-grasp domain; Region: ATP-grasp_4; cl17255 114615009903 3-oxoacyl-(acyl-carrier-protein) reductase; Region: 3oxo_ACP_reduc; TIGR01830 114615009904 classical (c) SDRs; Region: SDR_c; cd05233 114615009905 NAD(P) binding site [chemical binding]; other site 114615009906 active site 114615009907 FAD dependent oxidoreductase; Region: DAO; pfam01266 114615009908 NAD-dependent, lactate dehydrogenase-like, 2-hydroxycarboxylate dehydrogenase family; Region: LDH_MDH_like; cl17195 114615009909 hydroxyglutarate oxidase; Provisional; Region: PRK11728 114615009910 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 114615009911 dimer interface [polypeptide binding]; other site 114615009912 conserved gate region; other site 114615009913 putative PBP binding loops; other site 114615009914 ABC-ATPase subunit interface; other site 114615009915 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 114615009916 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 114615009917 substrate binding pocket [chemical binding]; other site 114615009918 membrane-bound complex binding site; other site 114615009919 hinge residues; other site 114615009920 Ketopantoate reductase PanE/ApbA; Region: ApbA; pfam02558 114615009921 Uncharacterized conserved protein [Function unknown]; Region: COG1284 114615009922 aromatic amino acid aminotransferase; Provisional; Region: PRK09257 114615009923 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 114615009924 pyridoxal 5'-phosphate binding site [chemical binding]; other site 114615009925 homodimer interface [polypeptide binding]; other site 114615009926 catalytic residue [active] 114615009927 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312 114615009928 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 114615009929 substrate binding pocket [chemical binding]; other site 114615009930 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 114615009931 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK05565 114615009932 classical (c) SDRs; Region: SDR_c; cd05233 114615009933 NAD(P) binding site [chemical binding]; other site 114615009934 active site 114615009935 Uncharacterized protein conserved in bacteria (DUF2155); Region: DUF2155; pfam09923 114615009936 leucyl/phenylalanyl-tRNA--protein transferase; Reviewed; Region: aat; PRK00301 114615009937 Response regulator receiver domain; Region: Response_reg; pfam00072 114615009938 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 114615009939 active site 114615009940 phosphorylation site [posttranslational modification] 114615009941 intermolecular recognition site; other site 114615009942 dimerization interface [polypeptide binding]; other site 114615009943 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920 114615009944 Histidine kinase; Region: HisKA_2; pfam07568 114615009945 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 114615009946 ATP binding site [chemical binding]; other site 114615009947 Mg2+ binding site [ion binding]; other site 114615009948 G-X-G motif; other site 114615009949 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 114615009950 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 114615009951 active site 114615009952 phosphorylation site [posttranslational modification] 114615009953 intermolecular recognition site; other site 114615009954 dimerization interface [polypeptide binding]; other site 114615009955 CHASE3 domain; Region: CHASE3; pfam05227 114615009956 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 114615009957 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cl00080 114615009958 dimer interface [polypeptide binding]; other site 114615009959 phosphorylation site [posttranslational modification] 114615009960 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 114615009961 ATP binding site [chemical binding]; other site 114615009962 Mg2+ binding site [ion binding]; other site 114615009963 G-X-G motif; other site 114615009964 acetyl-CoA carboxylase biotin carboxylase subunit; Validated; Region: PRK08591 114615009965 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 114615009966 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786 114615009967 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 114615009968 acetyl-CoA carboxylase biotin carboxyl carrier protein subunit; Validated; Region: PRK06302 114615009969 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 114615009970 carboxyltransferase (CT) interaction site; other site 114615009971 biotinylation site [posttranslational modification]; other site 114615009972 Dehydroquinase (DHQase), type II. Dehydroquinase (or 3-dehydroquinate dehydratase) catalyzes the reversible dehydration of 3-dehydroquinate to form 3-dehydroshikimate. This reaction is part of two metabolic pathways: the biosynthetic shikimate pathway...; Region: DHQase_II; cl00505 114615009973 dimer interface [polypeptide binding]; other site 114615009974 Protein of unknown function (DUF1236); Region: DUF1236; pfam06823 114615009975 tricarballylate utilization protein B; Provisional; Region: PRK15033 114615009976 tricarballylate dehydrogenase; Validated; Region: PRK08274 114615009977 Transcriptional regulators [Transcription]; Region: FadR; COG2186 114615009978 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 114615009979 DNA-binding site [nucleotide binding]; DNA binding site 114615009980 FCD domain; Region: FCD; pfam07729 114615009981 Protein-disulfide isomerase [Posttranslational modification, protein turnover, chaperones]; Region: DsbG; COG1651 114615009982 DsbA family, Com1-like subfamily; composed of proteins similar to Com1, a 27-kDa outer membrane-associated immunoreactive protein originally found in both acute and chronic disease strains of the pathogenic bacteria Coxiella burnetti. It contains a CXXC...; Region: DsbA_Com1_like; cd03023 114615009983 catalytic residues [active] 114615009984 Peptidase family M48; Region: Peptidase_M48; cl12018 114615009985 Tetratricopeptide repeat; Region: TPR_16; pfam13432 114615009986 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 114615009987 TPR motif; other site 114615009988 binding surface 114615009989 aspartate aminotransferase; Provisional; Region: PRK05764 114615009990 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 114615009991 pyridoxal 5'-phosphate binding site [chemical binding]; other site 114615009992 homodimer interface [polypeptide binding]; other site 114615009993 catalytic residue [active] 114615009994 C4-dicarboxylate transporter DctA; Reviewed; Region: PRK01663 114615009995 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 114615009996 S1_RNase_E: RNase E and RNase G, S1-like RNA-binding domain. RNase E is an essential endoribonuclease in the processing and degradation of RNA. In addition to its role in mRNA degradation, RNase E has also been implicated in the processing of rRNA, and...; Region: S1_RNase_E; cd04453 114615009997 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 114615009998 Ribonuclease E/G family; Region: RNase_E_G; pfam10150 114615009999 AMIN domain; Region: AMIN; pfam11741 114615010000 N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860 114615010001 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 114615010002 active site 114615010003 metal binding site [ion binding]; metal-binding site 114615010004 Membrane carboxypeptidase/penicillin-binding protein [Cell envelope biogenesis, outer membrane]; Region: MrcA; COG5009 114615010005 Transglycosylase; Region: Transgly; pfam00912 114615010006 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 114615010007 peptide chain release factor 2; Provisional; Region: PRK07342 114615010008 This domain is found in peptide chain release factors; Region: PCRF; smart00937 114615010009 RF-1 domain; Region: RF-1; pfam00472 114615010010 NAD binding domain of 6-phosphogluconate dehydrogenase; Region: NAD_binding_2; pfam03446 114615010011 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 114615010012 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 114615010013 active site 114615010014 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; COG0475 114615010015 Sodium/hydrogen exchanger family; Region: Na_H_Exchanger; pfam00999 114615010016 Kef-type K+ transport systems, predicted NAD-binding component [Inorganic ion transport and metabolism]; Region: Kch; COG1226 114615010017 TrkA-N domain; Region: TrkA_N; pfam02254 114615010018 Protein of unknown function (DUF3124); Region: DUF3124; pfam11322 114615010019 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 114615010020 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 114615010021 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 114615010022 DNA-binding site [nucleotide binding]; DNA binding site 114615010023 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 114615010024 pyridoxal 5'-phosphate binding site [chemical binding]; other site 114615010025 homodimer interface [polypeptide binding]; other site 114615010026 catalytic residue [active] 114615010027 capreomycidine synthase; Region: viomycin_VioD; TIGR03947 114615010028 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 114615010029 pyridoxal 5'-phosphate binding site [chemical binding]; other site 114615010030 homodimer interface [polypeptide binding]; other site 114615010031 catalytic residue [active] 114615010032 cystathionine beta-lyase; Provisional; Region: PRK07050 114615010033 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 114615010034 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 114615010035 catalytic residue [active] 114615010036 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 114615010037 Phosphopantetheine attachment site; Region: PP-binding; cl09936 114615010038 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 114615010039 Peptidase family M23; Region: Peptidase_M23; pfam01551 114615010040 Peroxiredoxin (PRX) family, Bacterioferritin comigratory protein (BCP) subfamily; composed of thioredoxin-dependent thiol peroxidases, widely expressed in pathogenic bacteria, that protect cells against toxicity from reactive oxygen species by reducing...; Region: PRX_BCP; cd03017 114615010041 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 114615010042 catalytic triad [active] 114615010043 Protein of unknown function; Region: DUF3971; pfam13116 114615010044 AsmA-like C-terminal region; Region: AsmA_2; pfam13502 114615010045 Major Facilitator Superfamily; Region: MFS_1; pfam07690 114615010046 tyrosyl-tRNA synthetase; Validated; Region: PRK05912 114615010047 catalytic core domain of tyrosinyl-tRNA synthetase; Region: TyrRS_core; cd00805 114615010048 active site 114615010049 HIGH motif; other site 114615010050 dimer interface [polypeptide binding]; other site 114615010051 KMSKS motif; other site 114615010052 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 114615010053 RNA binding surface [nucleotide binding]; other site 114615010054 anhydro-N-acetylmuramic acid kinase; Reviewed; Region: anmK; PRK09585 114615010055 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 114615010056 Glutathione S-transferase (GST) family, N-terminal domain; a large, diverse group of cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of endogenous and xenobiotic...; Region: GST_N_family; cd00570 114615010057 C-terminal domain interface [polypeptide binding]; other site 114615010058 GSH binding site (G-site) [chemical binding]; other site 114615010059 dimer interface [polypeptide binding]; other site 114615010060 C-terminal, alpha helical domain of the Glutathione S-transferase family; Region: GST_C_family; cd00299 114615010061 N-terminal domain interface [polypeptide binding]; other site 114615010062 dimer interface [polypeptide binding]; other site 114615010063 substrate binding pocket (H-site) [chemical binding]; other site 114615010064 Predicted hydrolase of the alpha/beta superfamily [General function prediction only]; Region: COG2945 114615010065 LytTr DNA-binding domain; Region: LytTR; smart00850 114615010066 glucans biosynthesis protein; Provisional; Region: opgC; PRK03854 114615010067 Acyltransferase family; Region: Acyl_transf_3; pfam01757 114615010068 Cysteine sulfinate desulfinase/cysteine desulfurase and related enzymes [Amino acid transport and metabolism]; Region: NifS; COG1104 114615010069 cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402 114615010070 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 114615010071 catalytic residue [active] 114615010072 cysteine desulfurase activator complex subunit SufB; Provisional; Region: PRK11814 114615010073 putative ABC transporter; Region: ycf24; CHL00085 114615010074 Cysteine desulfurase activator ATPase [Posttranslational modification, protein turnover, chaperones]; Region: sufC; COG0396 114615010075 ABC-type transport system involved in Fe-S cluster assembly, ATPase component; Region: ABC_FeS_Assembly; cd03217 114615010076 Walker A/P-loop; other site 114615010077 ATP binding site [chemical binding]; other site 114615010078 Q-loop/lid; other site 114615010079 ABC transporter signature motif; other site 114615010080 Walker B; other site 114615010081 D-loop; other site 114615010082 H-loop/switch region; other site 114615010083 Cysteine desulfurase activator SufB [Posttranslational modification, protein turnover, chaperones]; Region: SufB; COG0719 114615010084 FeS assembly protein SufD; Region: sufD; TIGR01981 114615010085 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 114615010086 Cysteine desulfurase (SufS)-like. This family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to cysteine desulfurase (SufS) and selenocysteine lyase. SufS...; Region: SufS_like; cd06453 114615010087 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 114615010088 catalytic residue [active] 114615010089 FeS assembly SUF system protein; Region: SUF_assoc; TIGR02945 114615010090 Fe-S cluster assembly scaffold protein [Posttranslational modification, protein turnover, chaperones]; Region: sufA; COG0316 114615010091 TfoX N-terminal domain; Region: TfoX_N; pfam04993 114615010092 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 114615010093 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 114615010094 metal binding site [ion binding]; metal-binding site 114615010095 active site 114615010096 I-site; other site 114615010097 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 114615010098 DEAD-like helicases superfamily; Region: DEXDc; smart00487 114615010099 ATP binding site [chemical binding]; other site 114615010100 Mg++ binding site [ion binding]; other site 114615010101 motif III; other site 114615010102 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 114615010103 nucleotide binding region [chemical binding]; other site 114615010104 ATP-binding site [chemical binding]; other site 114615010105 Protein of unknown function (DUF1211); Region: DUF1211; pfam06736 114615010106 Caspase domain; Region: Peptidase_C14; pfam00656 114615010107 active site 114615010108 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 114615010109 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 114615010110 NAD(P) binding site [chemical binding]; other site 114615010111 active site 114615010112 DNA topoisomerase IV subunit B; Reviewed; Region: PRK05559 114615010113 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 114615010114 ATP binding site [chemical binding]; other site 114615010115 Mg2+ binding site [ion binding]; other site 114615010116 G-X-G motif; other site 114615010117 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822 114615010118 anchoring element; other site 114615010119 dimer interface [polypeptide binding]; other site 114615010120 ATP binding site [chemical binding]; other site 114615010121 Topoisomerase-primase domain. This is a nucleotidyl transferase/hydrolase domain found in type IA, type IIA and type IIB topoisomerases, bacterial DnaG-type primases, small primase-like proteins from bacteria and archaea, OLD family nucleases from...; Region: TOPRIM; cl00718 114615010122 active site 114615010123 metal binding site [ion binding]; metal-binding site 114615010124 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 114615010125 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 114615010126 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 114615010127 Putative FMN-binding domain; Region: FMN_bind_2; pfam04299 114615010128 N-acetyl-gamma-glutamyl-phosphate reductase; Provisional; Region: PRK11863 114615010129 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 114615010130 threonine dehydratase; Provisional; Region: PRK07334 114615010131 Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562 114615010132 tetramer interface [polypeptide binding]; other site 114615010133 pyridoxal 5'-phosphate binding site [chemical binding]; other site 114615010134 catalytic residue [active] 114615010135 C-terminal ACT domain of biodegradative (catabolic) threonine dehydratase II (ThrD-II) and other related ACT domains; Region: ACT_ThrD-II-like; cd04886 114615010136 RNA ligase; Region: RNA_lig_T4_1; pfam09511 114615010137 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 114615010138 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 114615010139 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 114615010140 dimer interface [polypeptide binding]; other site 114615010141 conserved gate region; other site 114615010142 putative PBP binding loops; other site 114615010143 ABC-ATPase subunit interface; other site 114615010144 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 114615010145 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 114615010146 dimer interface [polypeptide binding]; other site 114615010147 conserved gate region; other site 114615010148 putative PBP binding loops; other site 114615010149 ABC-ATPase subunit interface; other site 114615010150 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 114615010151 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 114615010152 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 114615010153 Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GAT_1; cl00020 114615010154 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 114615010155 DNA binding site [nucleotide binding] 114615010156 domain linker motif; other site 114615010157 Periplasmic sugar-binding domain of uncharacterized transport systems; Region: PBP1_uncharacterized_sugar_binding; cd06307 114615010158 Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407 114615010159 putative ligand binding site [chemical binding]; other site 114615010160 MAPEG family; Region: MAPEG; pfam01124 114615010161 poly(R)-hydroxyalkanoic acid synthase, class I; Region: PHA_synth_I; TIGR01838 114615010162 Poly-beta-hydroxybutyrate polymerase (PhaC) N-terminus; Region: PhaC_N; pfam07167 114615010163 aminotransferase; Validated; Region: PRK09148 114615010164 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 114615010165 pyridoxal 5'-phosphate binding site [chemical binding]; other site 114615010166 homodimer interface [polypeptide binding]; other site 114615010167 catalytic residue [active] 114615010168 homoserine dehydrogenase; Provisional; Region: PRK06349 114615010169 Homoserine dehydrogenase, NAD binding domain; Region: NAD_binding_3; pfam03447 114615010170 Homoserine dehydrogenase; Region: Homoserine_dh; pfam00742 114615010171 ACT_HSDH_Hom CD includes the C-terminal ACT domain of the NAD(P)H-dependent, homoserine dehydrogenase (HSDH) and related domains; Region: ACT_HSDH-Hom; cd04881 114615010172 Bacterial fructose-1,6-bisphosphatase, glpX-encoded; Region: FBPase_glpX; pfam03320 114615010173 Bacterial fructose-1,6-bisphosphatase, glpX-encoded. A dimeric enzyme dependent on Mg(2+). glpX-encoded FPBase (FBPase class II) differs from other members of the inositol-phosphatase superfamily by permutation of secondary structure elements. The core...; Region: FBPase_glpX; cd01516 114615010174 putative active site [active] 114615010175 2-haloalkanoic acid dehalogenase, type II; Region: HAD_type_II; TIGR01428 114615010176 Haloacid dehalogenase superfamily, subfamily IA, variant 2 with 3rd motif like haloacid dehalogenase; Region: HAD-SF-IA-v2; TIGR01493 114615010177 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 114615010178 dimer interface [polypeptide binding]; other site 114615010179 putative CheW interface [polypeptide binding]; other site 114615010180 single-stranded-DNA-specific exonuclease RecJ; Region: recJ; TIGR00644 114615010181 DHH family; Region: DHH; pfam01368 114615010182 DHHA1 domain; Region: DHHA1; pfam02272 114615010183 Uncharacterized subfamily of N-terminal LabA-like domains; Region: LabA_like_N_1; cd11297 114615010184 putative metal binding site [ion binding]; other site 114615010185 Uncharacterized conserved protein [Function unknown]; Region: COG1432 114615010186 C-terminal domain of LabA_like proteins; Region: LabA_like_C; cd10146 114615010187 lytic murein transglycosylase; Region: MltB_2; TIGR02283 114615010188 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 114615010189 N-acetyl-D-glucosamine binding site [chemical binding]; other site 114615010190 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 114615010191 MarR family; Region: MarR_2; pfam12802 114615010192 Carboxymuconolactone decarboxylase family; Region: CMD; pfam02627 114615010193 Uncharacterized conserved protein [Function unknown]; Region: COG2128 114615010194 Peptidase family M23; Region: Peptidase_M23; pfam01551 114615010195 elongation factor P; Validated; Region: PRK00529 114615010196 Elongation factor P (EF-P) KOW-like domain; Region: EFP_N; pfam08207 114615010197 S1_EF-P_repeat_1: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_1; cd04470 114615010198 RNA binding site [nucleotide binding]; other site 114615010199 S1_EF-P_repeat_2: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_2; cd05794 114615010200 RNA binding site [nucleotide binding]; other site 114615010201 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 114615010202 EF-P lysine aminoacylase GenX; Region: genX; TIGR00462 114615010203 motif 1; other site 114615010204 dimer interface [polypeptide binding]; other site 114615010205 active site 114615010206 motif 2; other site 114615010207 motif 3; other site 114615010208 Lysine 2,3-aminomutase [Amino acid transport and metabolism]; Region: KamA; COG1509 114615010209 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 114615010210 FeS/SAM binding site; other site 114615010211 Lysine-2,3-aminomutase; Region: LAM_C; pfam12544 114615010212 phospho-2-dehydro-3-deoxyheptonate aldolase; Validated; Region: PRK09261 114615010213 DAHP synthetase I family; Region: DAHP_synth_1; pfam00793 114615010214 Uncharacterized conserved protein [Function unknown]; Region: HdeD; COG3247 114615010215 Protease prsW family; Region: PrsW-protease; pfam13367 114615010216 pyridoxal phosphate-dependent acyltransferase, putative; Region: gly_Cac_T_rel; TIGR01825 114615010217 KBL_like; this family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to serine palmitoyltransferase (SPT), 5-aminolevulinate synthase (ALAS); Region: KBL_like; cd06454 114615010218 substrate-cofactor binding pocket; other site 114615010219 pyridoxal 5'-phosphate binding site [chemical binding]; other site 114615010220 catalytic residue [active] 114615010221 Hemerythrin-like domain; Region: Hr-like; cd12108 114615010222 Fe binding site [ion binding]; other site 114615010223 Toluene-4-monooxygenase effector protein complex (T4mo), Rieske ferredoxin subunit; The Rieske domain is a [2Fe-2S] cluster binding domain involved in electron transfer. T4mo is a four-protein complex that catalyzes the NADH- and O2-dependent...; Region: Rieske_T4moC; cd03474 114615010224 [2Fe-2S] cluster binding site [ion binding]; other site 114615010225 DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182 114615010226 DNA binding site [nucleotide binding] 114615010227 Int/Topo IB signature motif; other site 114615010228 active site 114615010229 catalytic residues [active] 114615010230 Prophage CP4-57 regulatory protein (AlpA); Region: Phage_AlpA; cl17523 114615010231 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 114615010232 Catalytic site [active] 114615010233 Uncharacterized protein conserved in bacteria (DUF2312); Region: DUF2312; pfam10073 114615010234 HNH endonuclease; Region: HNH_3; pfam13392 114615010235 ParB-like nuclease domain; Region: ParBc; cl02129 114615010236 MT-A70; Region: MT-A70; cl01947 114615010237 Helix-turn-helix domain; Region: HTH_36; pfam13730 114615010238 Transcription termination factor nusG; Region: NusG; pfam02357 114615010239 transcription termination/antitermination factor NusG; Region: nusG; TIGR00922 114615010240 NusG contains an NGN domain at its N-terminus and KOW motif at its C-terminus; Region: KOW_NusG; cd06091 114615010241 heterodimer interface [polypeptide binding]; other site 114615010242 homodimer interface [polypeptide binding]; other site 114615010243 Restriction endonuclease [Defense mechanisms]; Region: McrA; COG1403 114615010244 This domain contains a conserved N-terminal (F/Y)RG motif. It is functionally uncharacterised; Region: FRG; smart00901 114615010245 Phage terminase-like protein, large subunit [General function prediction only]; Region: COG4626 114615010246 Phage portal protein; Region: Phage_portal; pfam04860 114615010247 Phage-related protein [Function unknown]; Region: COG4695; cl01923 114615010248 Signal peptide peptidase A (SppA) 36K type, a serine protease, has catalytic Ser-Lys dyad; Region: S49_Sppa_36K_type; cd07022 114615010249 tandem repeat interface [polypeptide binding]; other site 114615010250 oligomer interface [polypeptide binding]; other site 114615010251 active site residues [active] 114615010252 phage major capsid protein, HK97 family; Region: major_cap_HK97; TIGR01554 114615010253 Phage capsid family; Region: Phage_capsid; pfam05065 114615010254 phage conserved hypothetical protein, phiE125 gp8 family; Region: phage_chp_gp8; TIGR02215 114615010255 Head-Tail Connector Protein gp6 of Bacteriophage HK97 and similar proteins; Region: gp6; cd08054 114615010256 Domain of unknown function (DUF1833); Region: DUF1833; pfam08875 114615010257 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 114615010258 Putative phage tail protein; Region: Phage-tail_3; pfam13550 114615010259 TIGR02594 family protein; Region: TIGR02594 114615010260 PilZ domain; Region: PilZ; pfam07238 114615010261 Porin subfamily; Region: Porin_2; pfam02530 114615010262 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 114615010263 GST_N family, unknown subfamily 2; composed of uncharacterized bacterial proteins with similarity to GSTs. GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of...; Region: GST_N_2; cd03047 114615010264 putative C-terminal domain interface [polypeptide binding]; other site 114615010265 putative GSH binding site (G-site) [chemical binding]; other site 114615010266 putative dimer interface [polypeptide binding]; other site 114615010267 C-terminal, alpha helical domain of an unknown subfamily 2 of Glutathione S-transferases; Region: GST_C_2; cd03180 114615010268 putative N-terminal domain interface [polypeptide binding]; other site 114615010269 putative dimer interface [polypeptide binding]; other site 114615010270 putative substrate binding pocket (H-site) [chemical binding]; other site 114615010271 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 114615010272 Glyoxalase I catalyzes the isomerization of the hemithioacetal, formed by a 2-oxoaldehyde and glutathione, to S-D-lactoylglutathione; Region: Glyoxalase_I; cd07233 114615010273 dimer interface [polypeptide binding]; other site 114615010274 active site 114615010275 metal binding site [ion binding]; metal-binding site 114615010276 glutathione binding site [chemical binding]; other site 114615010277 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cl00257 114615010278 IHF dimer interface [polypeptide binding]; other site 114615010279 IHF - DNA interface [nucleotide binding]; other site 114615010280 NAD-dependent deacetylase; Provisional; Region: PRK00481 114615010281 SIR2 superfamily of proteins includes silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein/histone deacetylation, where the acetyl group from the lysine epsilon-amino group is transferred to the ADP-ribose moiety of NAD+; Region: SIR2; cl00195 114615010282 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 114615010283 DNA-binding site [nucleotide binding]; DNA binding site 114615010284 RNA-binding motif; other site 114615010285 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 114615010286 DNA-binding site [nucleotide binding]; DNA binding site 114615010287 RNA-binding motif; other site 114615010288 OpgC protein; Region: OpgC_C; pfam10129 114615010289 ETC complex I subunit conserved region; Region: ETC_C1_NDUFA4; pfam04800 114615010290 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 114615010291 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 114615010292 putative DNA binding site [nucleotide binding]; other site 114615010293 putative Zn2+ binding site [ion binding]; other site 114615010294 AsnC family; Region: AsnC_trans_reg; pfam01037 114615010295 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 114615010296 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 114615010297 Bacterial transcriptional repressor; Region: TetR_C_6; pfam13977 114615010298 3-methylcrotonyl-CoA carboxylase, beta chain; Region: PLN02820 114615010299 Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; cl17345 114615010300 Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; cl17345 114615010301 Acetyl/propionyl-CoA carboxylase, alpha subunit [Lipid metabolism]; Region: COG4770 114615010302 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 114615010303 ATP-grasp domain; Region: ATP-grasp_4; cl17255 114615010304 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 114615010305 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 114615010306 carboxyltransferase (CT) interaction site; other site 114615010307 biotinylation site [posttranslational modification]; other site 114615010308 Isopropylmalate/homocitrate/citramalate synthases [Amino acid transport and metabolism]; Region: LeuA; COG0119 114615010309 3-hydroxy-3-methylglutaryl-CoA lyase, catalytic TIM barrel domain; Region: DRE_TIM_HMGL; cd07938 114615010310 active site 114615010311 catalytic residues [active] 114615010312 metal binding site [ion binding]; metal-binding site 114615010313 DctM-like transporters; Region: DctM; pfam06808 114615010314 TRAP-type C4-dicarboxylate transport system, large permease component [Carbohydrate transport and metabolism]; Region: DctQ; COG1593 114615010315 Tripartite ATP-independent periplasmic transporters, DctQ component; Region: DctQ; pfam04290 114615010316 Bacterial extracellular solute-binding protein, family 7; Region: SBP_bac_7; cl15441 114615010317 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cd02883 114615010318 nudix motif; other site 114615010319 Truncated hemoglobins (trHbs) are a family of oxygen-binding heme proteins found in cyanobacteria, eubacteria, unicellular eukaryotes, and plants. The truncated hemoglobins have a characteristic two-over-two alpha helical folding pattern that is distinct...; Region: Trunc_globin; cd00454 114615010320 apolar tunnel; other site 114615010321 heme binding site [chemical binding]; other site 114615010322 dimerization interface [polypeptide binding]; other site 114615010323 Response regulator receiver domain; Region: Response_reg; pfam00072 114615010324 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 114615010325 active site 114615010326 phosphorylation site [posttranslational modification] 114615010327 intermolecular recognition site; other site 114615010328 dimerization interface [polypeptide binding]; other site 114615010329 Putative MetA-pathway of phenol degradation; Region: Phenol_MetA_deg; cl01768 114615010330 Transcriptional regulator [Transcription]; Region: LysR; COG0583 114615010331 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 114615010332 The C-terminal substsrate binding domain of NodD family of LysR-type transcriptional regulators that regulates the expression of nodulation (nod) genes; contains the type 2 periplasmic binding fold; Region: PBP2_NodD; cd08462 114615010333 putative substrate binding pocket [chemical binding]; other site 114615010334 putative dimerization interface [polypeptide binding]; other site 114615010335 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 114615010336 C-terminal domain of Burkholderia sp. NF100 MhqB and similar proteins; MhqB is a type I extradiol dioxygenase involved in the catabolism of methylhydroquinone, an intermediate in the degradation of fenitrothion; Region: MhqB_like_C; cd08360 114615010337 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 114615010338 putative active site [active] 114615010339 putative metal binding site [ion binding]; other site 114615010340 Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cd03467 114615010341 iron-sulfur cluster [ion binding]; other site 114615010342 [2Fe-2S] cluster binding site [ion binding]; other site 114615010343 hypothetical protein; Provisional; Region: PRK06847 114615010344 hypothetical protein; Provisional; Region: PRK07236 114615010345 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 114615010346 Cupin domain; Region: Cupin_2; pfam07883 114615010347 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557 114615010348 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 114615010349 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 114615010350 NAD(P) binding site [chemical binding]; other site 114615010351 active site 114615010352 short chain dehydrogenase; Provisional; Region: PRK06181 114615010353 classical (c) SDRs; Region: SDR_c; cd05233 114615010354 NAD(P) binding site [chemical binding]; other site 114615010355 active site 114615010356 Peroxiredoxin (PRX)-like 2 family; hypothetical proteins that show sequence similarity to PRXs. Members of this group contain a CXXC motif, similar to TRX. The second cysteine in the motif corresponds to the peroxidatic cysteine of PRX, however, these...; Region: PRX_like2; cd02970 114615010357 putative catalytic residues [active] 114615010358 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 114615010359 Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024 114615010360 substrate binding site [chemical binding]; other site 114615010361 oxyanion hole (OAH) forming residues; other site 114615010362 trimer interface [polypeptide binding]; other site 114615010363 Transcriptional regulator [Transcription]; Region: LysR; COG0583 114615010364 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 114615010365 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 114615010366 putative effector binding pocket; other site 114615010367 dimerization interface [polypeptide binding]; other site 114615010368 polynucleotide kinase-phosphatase; Region: bacter_Pnkp; TIGR04075 114615010369 Bacillus subtilis PrpE and related proteins, metallophosphatase domain; Region: MPP_PrpE; cd07423 114615010370 active site 114615010371 metal binding site [ion binding]; metal-binding site 114615010372 RNA repair, ligase-Pnkp-associating, region of Hen1; Region: Hen1_L; pfam12623 114615010373 3' terminal RNA ribose 2'-O-methyltransferase Hen1; Region: bacter_Hen1; TIGR04074 114615010374 TROVE domain; Region: TROVE; pfam05731 114615010375 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057 114615010376 metal ion-dependent adhesion site (MIDAS); other site 114615010377 Proteins of this family catalyze the reduction of flavin or nitrocompounds using NAD(P)H as electron donor in a obligatory two-electron transfer, utilizing FMN or FAD as cofactor. They are often found to be homodimers. Enzymes of this family are...; Region: Nitro_FMN_reductase; cl00514 114615010378 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 114615010379 GST_N family, Ure2p-like subfamily; composed of the Saccharomyces cerevisiae Ure2p and related GSTs. Ure2p is a regulator for nitrogen catabolism in yeast. It represses the expression of several gene products involved in the use of poor nitrogen sources...; Region: GST_N_Ure2p_like; cd03048 114615010380 C-terminal domain interface [polypeptide binding]; other site 114615010381 GSH binding site (G-site) [chemical binding]; other site 114615010382 dimer interface [polypeptide binding]; other site 114615010383 C-terminal, alpha helical domain of Ure2p and related Glutathione S-transferase-like proteins; Region: GST_C_Ure2p_like; cd03178 114615010384 dimer interface [polypeptide binding]; other site 114615010385 N-terminal domain interface [polypeptide binding]; other site 114615010386 Uncharacterized protein conserved in bacteria (DUF2236); Region: DUF2236; pfam09995 114615010387 Arsenate Reductase (ArsC) family, Yffb subfamily; Yffb is an uncharacterized bacterial protein encoded by the yffb gene, related to the thioredoxin-fold arsenic reductases, ArsC. The structure of Yffb and the conservation of the catalytic cysteine...; Region: ArsC_Yffb; cd03035 114615010388 ArsC family; Region: ArsC; pfam03960 114615010389 putative catalytic residues [active] 114615010390 Penicillinase repressor; Region: Pencillinase_R; pfam03965 114615010391 BlaR1 peptidase M56; Region: Peptidase_M56; pfam05569 114615010392 Domain of unknown function (DUF3471); Region: DUF3471; pfam11954 114615010393 Protein of unknown function (DUF1800); Region: DUF1800; pfam08811 114615010394 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4102 114615010395 Dipeptidyl aminopeptidases/acylaminoacyl-peptidases [Amino acid transport and metabolism]; Region: DAP2; COG1506 114615010396 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 114615010397 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411 114615010398 ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219 114615010399 Walker A/P-loop; other site 114615010400 ATP binding site [chemical binding]; other site 114615010401 Q-loop/lid; other site 114615010402 ABC transporter signature motif; other site 114615010403 Walker B; other site 114615010404 D-loop; other site 114615010405 H-loop/switch region; other site 114615010406 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410 114615010407 ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224 114615010408 Walker A/P-loop; other site 114615010409 ATP binding site [chemical binding]; other site 114615010410 Q-loop/lid; other site 114615010411 ABC transporter signature motif; other site 114615010412 Walker B; other site 114615010413 D-loop; other site 114615010414 H-loop/switch region; other site 114615010415 Periplasmic binding protein; Region: Peripla_BP_6; pfam13458 114615010416 Periplasmic solute-binding domain of active transport proteins that belong to the type I periplasmic binding fold protein family; Region: PBP1_SBP_like_1; cd06327 114615010417 putative ligand binding site [chemical binding]; other site 114615010418 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 114615010419 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 114615010420 TM-ABC transporter signature motif; other site 114615010421 ABC-type branched-chain amino acid transport system, permease component [Amino acid transport and metabolism]; Region: LivM; COG4177 114615010422 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 114615010423 TM-ABC transporter signature motif; other site 114615010424 Phosphate transport regulator (distant homolog of PhoU) [Inorganic ion transport and metabolism]; Region: COG1392 114615010425 Phosphate/sulphate permeases [Inorganic ion transport and metabolism]; Region: PitA; COG0306 114615010426 Peptide chain release factor RF-3 [Translation, ribosomal structure and biogenesis]; Region: PrfC; COG4108 114615010427 Release Factor 3 (RF3) protein involved in the terminal step of translocation in bacteria; Region: RF3; cd04169 114615010428 G1 box; other site 114615010429 putative GEF interaction site [polypeptide binding]; other site 114615010430 GTP/Mg2+ binding site [chemical binding]; other site 114615010431 Switch I region; other site 114615010432 G2 box; other site 114615010433 G3 box; other site 114615010434 Switch II region; other site 114615010435 G4 box; other site 114615010436 G5 box; other site 114615010437 RF3_II: this subfamily represents the domain II of bacterial Release Factor 3 (RF3). Termination of protein synthesis by the ribosome requires two release factor (RF) classes. The class II RF3 is a GTPase that removes class I RFs (RF1 or RF2) from the...; Region: RF3_II; cd03689 114615010438 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 114615010439 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 114615010440 DNA binding residues [nucleotide binding] 114615010441 dimerization interface [polypeptide binding]; other site 114615010442 Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]; Region: DegQ; COG0265 114615010443 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 114615010444 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 114615010445 protein binding site [polypeptide binding]; other site 114615010446 Asp/Glu/Hydantoin racemase; Region: Asp_Glu_race; cl00518 114615010447 NnrU protein; Region: NnrU; pfam07298 114615010448 Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318 114615010449 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 114615010450 acyl-activating enzyme (AAE) consensus motif; other site 114615010451 AMP binding site [chemical binding]; other site 114615010452 active site 114615010453 CoA binding site [chemical binding]; other site 114615010454 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4649 114615010455 GTP-binding protein Der; Reviewed; Region: PRK00093 114615010456 EngA1 GTPase contains the first domain of EngA; Region: EngA1; cd01894 114615010457 G1 box; other site 114615010458 GTP/Mg2+ binding site [chemical binding]; other site 114615010459 Switch I region; other site 114615010460 G2 box; other site 114615010461 Switch II region; other site 114615010462 G3 box; other site 114615010463 G4 box; other site 114615010464 G5 box; other site 114615010465 EngA2 GTPase contains the second domain of EngA; Region: EngA2; cd01895 114615010466 G1 box; other site 114615010467 GTP/Mg2+ binding site [chemical binding]; other site 114615010468 Switch I region; other site 114615010469 G2 box; other site 114615010470 G3 box; other site 114615010471 Switch II region; other site 114615010472 G4 box; other site 114615010473 G5 box; other site 114615010474 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 114615010475 sequence-specific DNA binding site [nucleotide binding]; other site 114615010476 salt bridge; other site 114615010477 Predicted transcriptional regulator [General function prediction only]; Region: COG3800 114615010478 Domain of unknown function (DUF955); Region: DUF955; pfam06114 114615010479 Predicted transcriptional regulator (DUF2083); Region: DUF2083; pfam09856 114615010480 isocitrate lyase; Provisional; Region: PRK15063 114615010481 Members of the ICL/PEPM enzyme family catalyze either P-C or C-C bond formation/cleavage. Known members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate hydrolase (OAH), isocitrate...; Region: ICL_PEPM; cd00377 114615010482 tetramer interface [polypeptide binding]; other site 114615010483 active site 114615010484 Mg2+/Mn2+ binding site [ion binding]; other site 114615010485 isocitrate lyase; Region: PLN02892 114615010486 Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280 114615010487 Exo-beta-1,3-glucanase [Carbohydrate transport and metabolism]; Region: COG5309 114615010488 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 114615010489 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 114615010490 active site 114615010491 Exo-beta-1,3-glucanase [Carbohydrate transport and metabolism]; Region: COG5309 114615010492 bifunctional N-acetylglucosamine-1-phosphate uridyltransferase/glucosamine-1-phosphate acetyltransferase; Provisional; Region: glmU; PRK14353 114615010493 N-terminal domain of bacterial GlmU; Region: GT2_GlmU_N_bac; cd02540 114615010494 Substrate binding site; other site 114615010495 Mg++ binding site; other site 114615010496 N-acetyl-glucosamine-1-phosphate uridyltransferase (GlmU), C-terminal left-handed beta-helix (LbH) acetyltransferase domain: GlmU is also known as UDP-N-acetylglucosamine pyrophosphorylase. It is a bifunctional bacterial enzyme that catalyzes two...; Region: LbH_GlmU_C; cd03353 114615010497 active site 114615010498 substrate binding site [chemical binding]; other site 114615010499 CoA binding site [chemical binding]; other site 114615010500 glucosamine--fructose-6-phosphate aminotransferase; Reviewed; Region: PRK00331 114615010501 Glutamine amidotransferases class-II (Gn-AT)_GFAT-type. This domain is found at the N-terminus of glucosamine-6P synthase (GlmS, or GFAT in humans). The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the appropriate substrate. In...; Region: GFAT; cd00714 114615010502 glutaminase active site [active] 114615010503 SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008 114615010504 dimer interface [polypeptide binding]; other site 114615010505 active site 114615010506 SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009 114615010507 dimer interface [polypeptide binding]; other site 114615010508 active site 114615010509 LysE type translocator; Region: LysE; cl00565 114615010510 Uncharacterized conserved protein [Function unknown]; Region: COG2928 114615010511 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_11; cd07261 114615010512 putative dimer interface [polypeptide binding]; other site 114615010513 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 114615010514 Triacylglycerol lipase-like subfamily of the SGNH hydrolases, a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its...; Region: Triacylglycerol_lipase_like; cd01847 114615010515 active site 114615010516 catalytic triad [active] 114615010517 oxyanion hole [active] 114615010518 type II secretion system protein G; Region: typeII_sec_gspG; TIGR01710 114615010519 Autotransporter beta-domain; Region: Autotransporter; pfam03797 114615010520 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084 114615010521 Domain of unknown function (DUF1932); Region: DUF1932; pfam09130 114615010522 ATP-dependent DNA helicase RecG; Provisional; Region: PRK10917 114615010523 RecG_wedge_OBF: A subfamily of OB folds corresponding to the OB fold found in the N-terminal (wedge) domain of Escherichia coli RecG. RecG is a branched-DNA-specific helicase, which catalyzes the interconversion of a DNA replication fork to a...; Region: RecG_wedge_OBF; cd04488 114615010524 ssDNA binding site; other site 114615010525 generic binding surface II; other site 114615010526 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 114615010527 ATP binding site [chemical binding]; other site 114615010528 putative Mg++ binding site [ion binding]; other site 114615010529 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 114615010530 nucleotide binding region [chemical binding]; other site 114615010531 ATP-binding site [chemical binding]; other site 114615010532 Flavinator of succinate dehydrogenase; Region: Sdh5; cl01110 114615010533 Transcription-repair coupling factor (superfamily II helicase) [DNA replication, recombination, and repair / Transcription]; Region: Mfd; COG1197 114615010534 CarD-like/TRCF domain; Region: CarD_TRCF; smart01058 114615010535 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 114615010536 ATP binding site [chemical binding]; other site 114615010537 putative Mg++ binding site [ion binding]; other site 114615010538 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 114615010539 nucleotide binding region [chemical binding]; other site 114615010540 ATP-binding site [chemical binding]; other site 114615010541 This domain is found in proteins necessary for strand-specific repair in DNA such as TRCF in Escherichia coli; Region: TRCF; smart00982 114615010542 PGAP1-like protein; Region: PGAP1; pfam07819 114615010543 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 114615010544 metal binding site [ion binding]; metal-binding site 114615010545 I-site; other site 114615010546 Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318 114615010547 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 114615010548 acyl-activating enzyme (AAE) consensus motif; other site 114615010549 active site 114615010550 AMP binding site [chemical binding]; other site 114615010551 CoA binding site [chemical binding]; other site 114615010552 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 114615010553 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_14; cd08497 114615010554 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cl01709 114615010555 Invasion associated locus B (IalB) protein; Region: IalB; pfam06776 114615010556 Hemimethylated DNA-binding protein YccV like; Region: YccV-like; pfam08755 114615010557 Predicted permeases [General function prediction only]; Region: COG0679 114615010558 2-octaprenyl-6-methoxyphenyl hydroxylase; Provisional; Region: PRK07494 114615010559 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 114615010560 Phosphatidylserine synthase [Lipid metabolism]; Region: PssA; COG1183 114615010561 CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; pfam01066 114615010562 Membrane protein TerC, possibly involved in tellurium resistance [Inorganic ion transport and metabolism]; Region: TerC; COG0861 114615010563 quinone oxidoreductase, NADPH-dependent; Provisional; Region: PRK10754 114615010564 Quinone oxidoreductase (QOR); Region: QOR2; cd05286 114615010565 NADP binding site [chemical binding]; other site 114615010566 dimer interface [polypeptide binding]; other site 114615010567 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 114615010568 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases [Energy production and conversion]; Region: COG2141 114615010569 acetylornithine transaminase protein; Provisional; Region: argD; PRK03715 114615010570 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 114615010571 inhibitor-cofactor binding pocket; inhibition site 114615010572 pyridoxal 5'-phosphate binding site [chemical binding]; other site 114615010573 catalytic residue [active] 114615010574 Uncharacterized protein conserved in bacteria (DUF2336); Region: DUF2336; pfam10098 114615010575 ribosomal protein S12 methylthiotransferase; Provisional; Region: rimO; PRK14862 114615010576 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 114615010577 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 114615010578 FeS/SAM binding site; other site 114615010579 Response regulator with putative antiterminator output domain [Signal transduction mechanisms]; Region: AmiR; COG3707 114615010580 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 114615010581 active site 114615010582 phosphorylation site [posttranslational modification] 114615010583 intermolecular recognition site; other site 114615010584 ANTAR domain; Region: ANTAR; pfam03861 114615010585 NMT1-like family; Region: NMT1_2; pfam13379 114615010586 ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components [Inorganic ion transport and metabolism]; Region: TauA; COG0715 114615010587 ferredoxin-nitrite reductase; Reviewed; Region: nirA; PRK09567 114615010588 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 114615010589 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 114615010590 sulfite reductase; Provisional; Region: PRK06214 114615010591 Cytochrome p450- like alpha subunits of E. coli sulfite reductase (SiR) multimerize with beta subunits to catalyze the NADPH dependent reduction of sulfite to sulfide. Beta subunits have an Fe4S4 cluster and a siroheme, while the alpha subunits (cysJ...; Region: SiR; cd06199 114615010592 FAD binding pocket [chemical binding]; other site 114615010593 FAD binding motif [chemical binding]; other site 114615010594 catalytic residues [active] 114615010595 NAD binding pocket [chemical binding]; other site 114615010596 phosphate binding motif [ion binding]; other site 114615010597 beta-alpha-beta structure motif; other site 114615010598 LamB/YcsF family of lactam utilization protein; Region: LamB_YcsF_like; cd10787 114615010599 putative active site [active] 114615010600 Allophanate hydrolase subunit 2; Region: AHS2; smart00797 114615010601 Allophanate hydrolase subunit 1; Region: AHS1; pfam02682 114615010602 Allophanate hydrolase subunit 1 [Amino acid transport and metabolism]; Region: DUR1; cl00896 114615010603 hypothetical protein; Validated; Region: PRK08245 114615010604 Uncharacterized conserved protein, contains double-stranded beta-helix domain [Function unknown]; Region: COG1917 114615010605 Uncharacterized protein conserved in bacteria (DUF2147); Region: DUF2147; pfam09917 114615010606 leucine-responsive transcriptional regulator; Provisional; Region: PRK11169 114615010607 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 114615010608 putative DNA binding site [nucleotide binding]; other site 114615010609 putative Zn2+ binding site [ion binding]; other site 114615010610 AsnC family; Region: AsnC_trans_reg; pfam01037 114615010611 1-aminocyclopropane-1-carboxylate deaminase [Amino acid transport and metabolism]; Region: Acd; COG2515 114615010612 Aminocyclopropane-1-carboxylate deaminase (ACCD): Pyridoxal phosphate (PLP)-dependent enzyme which catalyzes the conversion of 1-aminocyclopropane-L-carboxylate (ACC), a precursor of the plant hormone ethylene, to alpha-ketobutyrate and ammonia; Region: ACCD; cd06449 114615010613 pyridoxal 5'-phosphate binding site [chemical binding]; other site 114615010614 catalytic residue [active] 114615010615 elongation factor G; Reviewed; Region: PRK00007 114615010616 Elongation factor G (EF-G) family involved in both the elongation and ribosome recycling phases of protein synthesis; Region: EF-G; cd01886 114615010617 G1 box; other site 114615010618 putative GEF interaction site [polypeptide binding]; other site 114615010619 GTP/Mg2+ binding site [chemical binding]; other site 114615010620 Switch I region; other site 114615010621 G2 box; other site 114615010622 G3 box; other site 114615010623 Switch II region; other site 114615010624 G4 box; other site 114615010625 G5 box; other site 114615010626 EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088 114615010627 Elongation Factor G-like domain IV. This family includes the translational elongation factor termed EF-2 (for Archaea and Eukarya) and EF-G (for Bacteria), ribosomal protection proteins that mediate tetracycline resistance and, an evolutionarily...; Region: EFG_like_IV; cl02789 114615010628 EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G. Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713 114615010629 Acetyltransferase (GNAT) domain; Region: Acetyltransf_4; pfam13420 114615010630 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 114615010631 High-affinity nickel-transport protein; Region: NicO; cl00964 114615010632 High-affinity nickel-transport protein; Region: NicO; cl00964 114615010633 Transcriptional regulators RcnR and FrmR, and related domains; this domain family was previously known as part of DUF156; Region: RcnR-FrmR-like_DUF156; cd10153 114615010634 putative metal binding site [ion binding]; other site 114615010635 putative homodimer interface [polypeptide binding]; other site 114615010636 putative homotetramer interface [polypeptide binding]; other site 114615010637 putative homodimer-homodimer interface [polypeptide binding]; other site 114615010638 putative allosteric switch controlling residues; other site 114615010639 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 114615010640 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 114615010641 substrate binding pocket [chemical binding]; other site 114615010642 membrane-bound complex binding site; other site 114615010643 hinge residues; other site 114615010644 Domain of unknown function (DUF1993); Region: DUF1993; pfam09351 114615010645 Phosphoglycerate dehydrogenase and related dehydrogenases [Amino acid transport and metabolism]; Region: SerA; COG0111 114615010646 Phosphoglycerate dehydrogenases, NAD-binding and catalytic domains; Region: PGDH_4; cd12173 114615010647 ligand binding site [chemical binding]; other site 114615010648 NAD binding site [chemical binding]; other site 114615010649 dimerization interface [polypeptide binding]; other site 114615010650 catalytic site [active] 114615010651 glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650 114615010652 The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301 114615010653 Walker A/P-loop; other site 114615010654 ATP binding site [chemical binding]; other site 114615010655 Q-loop/lid; other site 114615010656 ABC transporter signature motif; other site 114615010657 Walker B; other site 114615010658 D-loop; other site 114615010659 H-loop/switch region; other site 114615010660 TOBE domain; Region: TOBE_2; pfam08402 114615010661 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 114615010662 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 114615010663 dimer interface [polypeptide binding]; other site 114615010664 conserved gate region; other site 114615010665 putative PBP binding loops; other site 114615010666 ABC-ATPase subunit interface; other site 114615010667 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 114615010668 dimer interface [polypeptide binding]; other site 114615010669 conserved gate region; other site 114615010670 putative PBP binding loops; other site 114615010671 ABC-ATPase subunit interface; other site 114615010672 Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416 114615010673 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 114615010674 Lipoproteins [Cell envelope biogenesis, outer membrane]; Region: RlpA; COG0797 114615010675 Rare lipoprotein A (RlpA)-like double-psi beta-barrel; Region: DPBB_1; pfam03330 114615010676 Immunoglobulin-like fold, Plexins, Transcription factors (IPT). IPTs are also known as Transcription factor ImmunoGlobin (TIG) domains. They are present in intracellular transcription factors, cell surface receptors (such as plexins and scatter factor...; Region: IPT; cd00102 114615010677 IPT domain of Plexins and Cell Surface Receptors (PCSR) and related proteins . This subgroup contains IPT domains of plexins, receptors, like the plasminogen-related growth factor receptors, the hepatocyte growth factor-scatter factors, and the...; Region: IPT_PCSR; cd00603 114615010678 Autotransporter beta-domain; Region: Autotransporter; smart00869 114615010679 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 114615010680 Coenzyme A binding pocket [chemical binding]; other site 114615010681 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 114615010682 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 114615010683 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872 114615010684 D-alanyl-D-alanine carboxypeptidase; Region: Peptidase_S11; pfam00768 114615010685 Penicillin-binding protein 5, C-terminal domain; Region: PBP5_C; pfam07943 114615010686 thymidylate kinase; Validated; Region: tmk; PRK00698 114615010687 Thymidine monophosphate kinase (TMPK), also known as thymidylate kinase, catalyzes the phosphorylation of thymidine monophosphate (TMP) to thymidine diphosphate (TDP) utilizing ATP as its preferred phophoryl donor. TMPK represents the rate-limiting step...; Region: TMPK; cd01672 114615010688 TMP-binding site; other site 114615010689 ATP-binding site [chemical binding]; other site 114615010690 DNA polymerase III subunit delta'; Validated; Region: PRK07471 114615010691 DNA polymerase III subunit delta'; Validated; Region: PRK08485 114615010692 methionyl-tRNA synthetase; Reviewed; Region: PRK11893 114615010693 catalytic core domain of methioninyl-tRNA synthetases; Region: MetRS_core; cd00814 114615010694 active site 114615010695 HIGH motif; other site 114615010696 KMSKS motif; other site 114615010697 Anticodon-binding domain of methionyl tRNA synthetases; Region: Anticodon_Ia_Met; cd07957 114615010698 tRNA binding surface [nucleotide binding]; other site 114615010699 anticodon binding site; other site 114615010700 Predicted metal-dependent hydrolases with the TIM-barrel fold [General function prediction only]; Region: COG1099 114615010701 TatD like proteins; E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310 114615010702 active site 114615010703 Metal-dependent hydrolases of the beta-lactamase superfamily I [General function prediction only]; Region: PhnP; COG1235 114615010704 putative hydrolase; Provisional; Region: PRK02113 114615010705 Antibiotic biosynthesis monooxygenase; Region: ABM; pfam03992 114615010706 acyl-CoA synthetase; Validated; Region: PRK08162 114615010707 Fatty acyl-CoA synthetases similar to LC-FACS from Thermus thermophiles and Arabidopsis; Region: ttLC_FACS_AEE21_like; cd12118 114615010708 acyl-activating enzyme (AAE) consensus motif; other site 114615010709 putative active site [active] 114615010710 AMP binding site [chemical binding]; other site 114615010711 putative CoA binding site [chemical binding]; other site 114615010712 TRAP-type C4-dicarboxylate transport system, small permease component [Carbohydrate transport and metabolism]; Region: DctM; COG3090 114615010713 DctM-like transporters; Region: DctM; pfam06808 114615010714 TRAP-type C4-dicarboxylate transport system, large permease component [Carbohydrate transport and metabolism]; Region: DctQ; COG1593 114615010715 TRAP-type C4-dicarboxylate transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: DctP; COG1638 114615010716 Bacterial extracellular solute-binding protein, family 7; Region: SBP_bac_7; pfam03480 114615010717 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411 114615010718 ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219 114615010719 Walker A/P-loop; other site 114615010720 ATP binding site [chemical binding]; other site 114615010721 Q-loop/lid; other site 114615010722 ABC transporter signature motif; other site 114615010723 Walker B; other site 114615010724 D-loop; other site 114615010725 H-loop/switch region; other site 114615010726 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410 114615010727 ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224 114615010728 Walker A/P-loop; other site 114615010729 ATP binding site [chemical binding]; other site 114615010730 Q-loop/lid; other site 114615010731 ABC transporter signature motif; other site 114615010732 Walker B; other site 114615010733 D-loop; other site 114615010734 H-loop/switch region; other site 114615010735 ABC-type branched-chain amino acid transport system, permease component [Amino acid transport and metabolism]; Region: LivM; COG4177 114615010736 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 114615010737 TM-ABC transporter signature motif; other site 114615010738 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 114615010739 TM-ABC transporter signature motif; other site 114615010740 ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683 114615010741 Type I periplasmic ligand-binding domain of uncharacterized ABC (Atpase Binding Cassette)-type active transport systems that are predicted to be involved in uptake of amino acids, peptides, or inorganic ions; Region: PBP1_ABC_ligand_binding_like_10; cd06345 114615010742 putative ligand binding site [chemical binding]; other site 114615010743 dihydrolipoamide succinyltransferase; Provisional; Region: PTZ00144 114615010744 Glycosyl hydrolase family 1; Region: Glyco_hydro_1; cl01046 114615010745 beta-galactosidase; Region: BGL; TIGR03356 114615010746 Nitrile hydratase, alpha chain; Region: NHase_alpha; pfam02979 114615010747 NHLP leader peptide domain; Region: TOMM_pelo; TIGR03793 114615010748 NHLP leader peptide domain; Region: TOMM_pelo; TIGR03793 114615010749 Nitrile hydratase beta subunit; Region: NHase_beta; pfam02211 114615010750 nitrile hydratase, beta subunit; Region: nitrile_beta; TIGR03888 114615010751 nitrile hydratase accessory protein; Region: nitrile_acc; TIGR03889 114615010752 ExsB is a transcription regulator related protein. It is a subfamily of a Adenosine nucleotide binding superfamily of proteins. This protein family is represented by a single member in nearly every completed large (> 1000 genes) prokaryotic genome. In...; Region: ExsB; cd01995 114615010753 Ligand Binding Site [chemical binding]; other site 114615010754 nucleoside triphosphate pyrophosphohydrolase; Reviewed; Region: mazG; PRK09562 114615010755 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) N-terminal tandem-domain of MazG proteins from Escherichia coli and bacterial homologs; Region: NTP-PPase_MazG_Nterm; cd11528 114615010756 homodimer interface [polypeptide binding]; other site 114615010757 metal binding site [ion binding]; metal-binding site 114615010758 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) C-terminal tandem-domain of MazG proteins from Escherichia coli and bacterial homologs' Region: NTP-PPase_MazG_Cterm; cd11529 114615010759 homodimer interface [polypeptide binding]; other site 114615010760 active site 114615010761 putative chemical substrate binding site [chemical binding]; other site 114615010762 metal binding site [ion binding]; metal-binding site 114615010763 Peptidase M15; Region: Peptidase_M15_3; cl01194 114615010764 GTP-binding protein HflX; Region: GTP_HflX; TIGR03156 114615010765 GTP-binding GTPase N-terminal; Region: GTP-bdg_N; pfam13167 114615010766 HflX GTPase family; Region: HflX; cd01878 114615010767 G1 box; other site 114615010768 GTP/Mg2+ binding site [chemical binding]; other site 114615010769 Switch I region; other site 114615010770 G2 box; other site 114615010771 G3 box; other site 114615010772 Switch II region; other site 114615010773 G4 box; other site 114615010774 G5 box; other site 114615010775 bacterial Hfq-like; Region: Hfq; cd01716 114615010776 hexamer interface [polypeptide binding]; other site 114615010777 Sm1 motif; other site 114615010778 RNA binding site [nucleotide binding]; other site 114615010779 Sm2 motif; other site 114615010780 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204 114615010781 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 114615010782 active site 114615010783 phosphorylation site [posttranslational modification] 114615010784 intermolecular recognition site; other site 114615010785 dimerization interface [polypeptide binding]; other site 114615010786 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 114615010787 Walker A motif; other site 114615010788 ATP binding site [chemical binding]; other site 114615010789 Walker B motif; other site 114615010790 arginine finger; other site 114615010791 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 114615010792 Signal transduction histidine kinase involved in nitrogen fixation and metabolism regulation [Signal transduction mechanisms]; Region: NtrY; COG5000 114615010793 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 114615010794 dimerization interface [polypeptide binding]; other site 114615010795 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 114615010796 putative active site [active] 114615010797 heme pocket [chemical binding]; other site 114615010798 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 114615010799 dimer interface [polypeptide binding]; other site 114615010800 phosphorylation site [posttranslational modification] 114615010801 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 114615010802 ATP binding site [chemical binding]; other site 114615010803 Mg2+ binding site [ion binding]; other site 114615010804 G-X-G motif; other site 114615010805 helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346 114615010806 Transcriptional regulator [Transcription]; Region: IclR; COG1414 114615010807 hypothetical protein; Validated; Region: PRK06201 114615010808 Demethylmenaquinone methyltransferase [Coenzyme metabolism]; Region: MenG; COG0684 114615010809 Phosphoglycerate dehydrogenases, NAD-binding and catalytic domains; Region: PGDH_4; cd12173 114615010810 ligand binding site [chemical binding]; other site 114615010811 NAD binding site [chemical binding]; other site 114615010812 dimerization interface [polypeptide binding]; other site 114615010813 catalytic site [active] 114615010814 4-hydroxyphenylacetate permease; Region: HpaX; TIGR02332 114615010815 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 114615010816 putative substrate translocation pore; other site 114615010817 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 114615010818 Predicted metal-dependent hydrolase of the TIM-barrel fold [General function prediction only]; Region: COG3618 114615010819 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 114615010820 active site 114615010821 Gluconolactonase [Carbohydrate transport and metabolism]; Region: COG3386 114615010822 Strictosidine synthase; Region: Str_synth; pfam03088 114615010823 Predicted metal-dependent hydrolase of the TIM-barrel fold [General function prediction only]; Region: COG3618 114615010824 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 114615010825 active site 114615010826 4-hydroxyphenylacetate permease; Region: HpaX; TIGR02332 114615010827 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 114615010828 putative substrate translocation pore; other site 114615010829 nitrogen regulation protein NR(I); Region: ntrC; TIGR01818 114615010830 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 114615010831 active site 114615010832 phosphorylation site [posttranslational modification] 114615010833 intermolecular recognition site; other site 114615010834 dimerization interface [polypeptide binding]; other site 114615010835 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 114615010836 Walker A motif; other site 114615010837 ATP binding site [chemical binding]; other site 114615010838 Walker B motif; other site 114615010839 Bacterial regulatory protein, Fis family; Region: HTH_8; cl17420 114615010840 Signal transduction histidine kinase, nitrogen specific [Signal transduction mechanisms]; Region: NtrB; COG3852 114615010841 PAS domain; Region: PAS; smart00091 114615010842 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 114615010843 dimer interface [polypeptide binding]; other site 114615010844 phosphorylation site [posttranslational modification] 114615010845 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 114615010846 ATP binding site [chemical binding]; other site 114615010847 Mg2+ binding site [ion binding]; other site 114615010848 G-X-G motif; other site 114615010849 putative TIM-barrel protein, nifR3 family; Region: nifR3_yhdG; TIGR00737 114615010850 Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801 114615010851 FMN binding site [chemical binding]; other site 114615010852 active site 114615010853 catalytic residues [active] 114615010854 substrate binding site [chemical binding]; other site 114615010855 bifunctional 2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase/2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase protein; Provisional; Region: ispDF; PRK09382 114615010856 CDP-ME synthetase is involved in mevalonate-independent isoprenoid production; Region: CDP-ME_synthetase; cd02516 114615010857 substrate binding site; other site 114615010858 dimer interface; other site 114615010859 MECDP_synthase (2-C-methyl-D-erythritol-2,4-cyclodiphosphate synthase), encoded by the ispF gene, catalyzes the formation of 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (MEC) in the non-mevalonate deoxyxylulose (DOXP) pathway for isoprenoid biosynthesis; Region: MECDP_synthase; cd00554 114615010860 homotrimer interaction site [polypeptide binding]; other site 114615010861 zinc binding site [ion binding]; other site 114615010862 CDP-binding sites; other site 114615010863 Competence-damaged protein; Region: CinA; pfam02464 114615010864 Guanosine polyphosphate pyrophosphohydrolases/synthetases [Signal transduction mechanisms / Transcription]; Region: SpoT; COG0317 114615010865 HD domain; Region: HD_4; pfam13328 114615010866 PAS domain; Region: PAS_9; pfam13426 114615010867 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459 114615010868 putative active site [active] 114615010869 heme pocket [chemical binding]; other site 114615010870 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 114615010871 dimer interface [polypeptide binding]; other site 114615010872 putative CheW interface [polypeptide binding]; other site 114615010873 Coenzyme Q-binding protein COQ10p and similar proteins; Region: COQ10p_like; cd07813 114615010874 putative coenzyme Q binding site [chemical binding]; other site 114615010875 lipoyl synthase; Provisional; Region: PRK05481 114615010876 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 114615010877 FeS/SAM binding site; other site 114615010878 Alkyladenine DNA glycosylase catalyzes the first step in base excision repair; Region: AAG; cd00540 114615010879 DNA binding site [nucleotide binding] 114615010880 active site 114615010881 valyl-tRNA synthetase; Reviewed; Region: valS; PRK05729 114615010882 catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817 114615010883 HIGH motif; other site 114615010884 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 114615010885 catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817 114615010886 active site 114615010887 KMSKS motif; other site 114615010888 Anticodon-binding domain of valyl tRNA synthetases; Region: Anticodon_Ia_Val; cd07962 114615010889 tRNA binding surface [nucleotide binding]; other site 114615010890 anticodon binding site; other site 114615010891 Valyl tRNA synthetase tRNA binding arm; Region: Val_tRNA-synt_C; pfam10458 114615010892 Protein of unknown function (DUF2497); Region: DUF2497; pfam10691 114615010893 type I secretion outer membrane protein, TolC family; Region: type_I_sec_TolC; TIGR01844 114615010894 Protein-L-isoaspartate carboxylmethyltransferase [Posttranslational modification, protein turnover, chaperones]; Region: Pcm; COG2518 114615010895 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 114615010896 S-adenosylmethionine binding site [chemical binding]; other site 114615010897 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447 114615010898 nudix motif; other site 114615010899 phosphonate utilization associated putative membrane protein; Region: phn_DUF6; TIGR03340 114615010900 Response regulator receiver domain; Region: Response_reg; pfam00072 114615010901 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 114615010902 active site 114615010903 phosphorylation site [posttranslational modification] 114615010904 intermolecular recognition site; other site 114615010905 dimerization interface [polypeptide binding]; other site 114615010906 Response regulator receiver domain; Region: Response_reg; pfam00072 114615010907 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 114615010908 active site 114615010909 phosphorylation site [posttranslational modification] 114615010910 intermolecular recognition site; other site 114615010911 dimerization interface [polypeptide binding]; other site 114615010912 PQQ-dependent dehydrogenase, methanol/ethanol family; Region: PQQ_enz_alc_DH; TIGR03075 114615010913 Ethanol dehydrogenase, a bacterial quinoprotein (PQQ-dependent type I alcohol dehydrogenase); Region: PQQ_ADH_I; cd10277 114615010914 dimer interface [polypeptide binding]; other site 114615010915 Trp docking motif [polypeptide binding]; other site 114615010916 active site 114615010917 Rieske Fe-S protein [Energy production and conversion]; Region: QcrA; COG0723 114615010918 Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cd03467 114615010919 iron-sulfur cluster [ion binding]; other site 114615010920 [2Fe-2S] cluster binding site [ion binding]; other site 114615010921 PBP superfamily domain; Region: PBP_like_2; cl17296 114615010922 Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885 114615010923 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 114615010924 ligand binding site [chemical binding]; other site 114615010925 DTW domain; Region: DTW; cl01221 114615010926 multidrug efflux system subunit MdtC; Provisional; Region: PRK10614 114615010927 multidrug efflux system subunit MdtB; Provisional; Region: PRK10503 114615010928 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 114615010929 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 114615010930 HlyD family secretion protein; Region: HlyD_3; pfam13437 114615010931 efflux transporter, outer membrane factor (OMF) lipoprotein, NodT family; Region: outer_NodT; TIGR01845 114615010932 Predicted NAD/FAD-binding protein [General function prediction only]; Region: COG2907 114615010933 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 114615010934 Protein of unknown function (DUF1365); Region: DUF1365; pfam07103 114615010935 Cyclopropane fatty acid synthase and related methyltransferases [Cell envelope biogenesis, outer membrane]; Region: Cfa; COG2230 114615010936 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 114615010937 S-adenosylmethionine binding site [chemical binding]; other site 114615010938 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 114615010939 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 114615010940 dimer interface [polypeptide binding]; other site 114615010941 pyridoxal 5'-phosphate binding site [chemical binding]; other site 114615010942 catalytic residue [active] 114615010943 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 114615010944 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 114615010945 Walker A/P-loop; other site 114615010946 ATP binding site [chemical binding]; other site 114615010947 Q-loop/lid; other site 114615010948 ABC transporter signature motif; other site 114615010949 Walker B; other site 114615010950 D-loop; other site 114615010951 H-loop/switch region; other site 114615010952 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 114615010953 dimer interface [polypeptide binding]; other site 114615010954 conserved gate region; other site 114615010955 putative PBP binding loops; other site 114615010956 ABC-ATPase subunit interface; other site 114615010957 ABC-type amino acid transport system, permease component [Amino acid transport and metabolism]; Region: BatB; COG4597 114615010958 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 114615010959 conserved gate region; other site 114615010960 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 114615010961 putative PBP binding loops; other site 114615010962 dimer interface [polypeptide binding]; other site 114615010963 ABC-ATPase subunit interface; other site 114615010964 lysine-arginine-ornithine-binding periplasmic protein; Region: 3A0103s03R; TIGR01096 114615010965 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 114615010966 substrate binding pocket [chemical binding]; other site 114615010967 membrane-bound complex binding site; other site 114615010968 hinge residues; other site 114615010969 cystathionine beta-lyase; Provisional; Region: PRK05967 114615010970 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 114615010971 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 114615010972 catalytic residue [active] 114615010973 Na+/phosphate symporter [Inorganic ion transport and metabolism]; Region: NptA; COG1283 114615010974 Na+/Pi-cotransporter; Region: Na_Pi_cotrans; pfam02690 114615010975 PhoU domain; Region: PhoU; pfam01895 114615010976 PhoU domain; Region: PhoU; pfam01895 114615010977 Lipid A Biosynthesis N-terminal domain; Region: LAB_N; cl01627 114615010978 dolichyl-phosphate beta-D-mannosyltransferase; Region: PLN02726 114615010979 DPM_DPG-synthase_like is a member of the Glycosyltransferase 2 superfamily; Region: DPM_DPG-synthase_like; cd04179 114615010980 Ligand binding site; other site 114615010981 Putative Catalytic site; other site 114615010982 DXD motif; other site 114615010983 PAP2_like proteins, a super-family of histidine phosphatases and vanadium haloperoxidases, includes type 2 phosphatidic acid phosphatase or lipid phosphate phosphatase (LPP), Glucose-6-phosphatase, Phosphatidylglycerophosphatase B and bacterial acid...; Region: PAP2_like; cl00474 114615010984 active site 114615010985 4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family [Cell envelope biogenesis, outer membrane]; Region: ArnT; COG1807 114615010986 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; cl17364 114615010987 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; cl17364 114615010988 penicillin-binding protein 1C; Region: PBP_1c; TIGR02073 114615010989 Transglycosylase; Region: Transgly; pfam00912 114615010990 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 114615010991 Penicillin-Binding Protein C-terminus Family; Region: BiPBP_C; pfam06832 114615010992 Large extracellular alpha-helical protein [General function prediction only]; Region: COG2373 114615010993 MG2 domain; Region: A2M_N; pfam01835 114615010994 Alpha-2-macroglobulin family; Region: A2M; pfam00207 114615010995 Proteins similar to alpha2-macroglobulin (alpha (2)-M). Alpha (2)-M is a major carrier protein in serum. It is a broadly specific proteinase inhibitor. The structural thioester of alpha (2)-M, is involved in the immobilization and entrapment of...; Region: A2M_like; cd02891 114615010996 surface patch; other site 114615010997 thioester region; other site 114615010998 specificity defining residues; other site 114615010999 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961 114615011000 Resolvase, N terminal domain; Region: Resolvase; smart00857 114615011001 Recombinase; Region: Recombinase; pfam07508 114615011002 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961 114615011003 Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cd00338 114615011004 catalytic nucleophile [active] 114615011005 methyltransferase, FkbM family; Region: fkbM_fam; TIGR01444 114615011006 PRC-barrel domain; Region: PRC; pfam05239 114615011007 oxidoreductase; Provisional; Region: PRK06128 114615011008 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 114615011009 NAD(P) binding site [chemical binding]; other site 114615011010 active site 114615011011 Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840 114615011012 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 114615011013 dimerization interface [polypeptide binding]; other site 114615011014 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 114615011015 dimerization interface [polypeptide binding]; other site 114615011016 Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840 114615011017 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 114615011018 dimerization interface [polypeptide binding]; other site 114615011019 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 114615011020 dimerization interface [polypeptide binding]; other site 114615011021 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 114615011022 dimerization interface [polypeptide binding]; other site 114615011023 Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840 114615011024 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 114615011025 dimerization interface [polypeptide binding]; other site 114615011026 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 114615011027 dimerization interface [polypeptide binding]; other site 114615011028 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 114615011029 dimerization interface [polypeptide binding]; other site 114615011030 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 114615011031 dimerization interface [polypeptide binding]; other site 114615011032 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 114615011033 dimerization interface [polypeptide binding]; other site 114615011034 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 114615011035 dimerization interface [polypeptide binding]; other site 114615011036 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 114615011037 GAF domain; Region: GAF; pfam01590 114615011038 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 114615011039 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 114615011040 dimer interface [polypeptide binding]; other site 114615011041 phosphorylation site [posttranslational modification] 114615011042 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 114615011043 ATP binding site [chemical binding]; other site 114615011044 Mg2+ binding site [ion binding]; other site 114615011045 G-X-G motif; other site 114615011046 Response regulator receiver domain; Region: Response_reg; pfam00072 114615011047 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 114615011048 active site 114615011049 phosphorylation site [posttranslational modification] 114615011050 intermolecular recognition site; other site 114615011051 dimerization interface [polypeptide binding]; other site 114615011052 Response regulator receiver domain; Region: Response_reg; pfam00072 114615011053 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 114615011054 active site 114615011055 phosphorylation site [posttranslational modification] 114615011056 intermolecular recognition site; other site 114615011057 dimerization interface [polypeptide binding]; other site 114615011058 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 114615011059 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 114615011060 active site 114615011061 phosphorylation site [posttranslational modification] 114615011062 intermolecular recognition site; other site 114615011063 dimerization interface [polypeptide binding]; other site 114615011064 Response regulator receiver domain; Region: Response_reg; pfam00072 114615011065 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 114615011066 active site 114615011067 phosphorylation site [posttranslational modification] 114615011068 intermolecular recognition site; other site 114615011069 dimerization interface [polypeptide binding]; other site 114615011070 PAS fold; Region: PAS_3; pfam08447 114615011071 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 114615011072 putative active site [active] 114615011073 heme pocket [chemical binding]; other site 114615011074 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920 114615011075 HWE histidine kinase; Region: HWE_HK; smart00911 114615011076 oxidoreductase alpha (molybdopterin) subunit; Region: Fdhalpha-like; TIGR01701 114615011077 The MopB_ydeP CD includes a group of related uncharacterized bacterial molybdopterin-binding oxidoreductase-like domains with a putative molybdopterin cofactor binding site. These members belong to the molybdopterin_binding (MopB) superfamily of proteins; Region: MopB_ydeP; cd02767 114615011078 putative molybdopterin cofactor binding site [chemical binding]; other site 114615011079 The MopB_CT_ydeP CD includes a group of related uncharacterized bacterial molybdopterin-binding oxidoreductase-like domains with a putative molybdopterin cofactor binding site. This CD is of the conserved molybdopterin_binding C-terminal (MopB_CT) region...; Region: MopB_CT_ydeP; cd02787 114615011080 putative molybdopterin cofactor binding site; other site 114615011081 A type 1 glutamine amidotransferase (GATase1)-like domain found in PfpI from Pyrococcus furiosus; Region: GATase1_PfpI_like; cd03134 114615011082 intracellular protease, PfpI family; Region: PfpI; TIGR01382 114615011083 proposed catalytic triad [active] 114615011084 conserved cys residue [active] 114615011085 Protein of unknown function (DUF3072); Region: DUF3072; pfam11272 114615011086 Beta-glucosidase-related glycosidases [Carbohydrate transport and metabolism]; Region: BglX; COG1472 114615011087 Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; cl07971 114615011088 Domain of unknown function (DUF4173); Region: DUF4173; pfam13777 114615011089 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 114615011090 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 114615011091 active site 114615011092 phosphorylation site [posttranslational modification] 114615011093 intermolecular recognition site; other site 114615011094 dimerization interface [polypeptide binding]; other site 114615011095 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 114615011096 DNA binding site [nucleotide binding] 114615011097 sensory histidine kinase CreC; Provisional; Region: PRK11100 114615011098 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054 114615011099 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 114615011100 dimer interface [polypeptide binding]; other site 114615011101 phosphorylation site [posttranslational modification] 114615011102 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 114615011103 ATP binding site [chemical binding]; other site 114615011104 Mg2+ binding site [ion binding]; other site 114615011105 G-X-G motif; other site 114615011106 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 114615011107 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_13; cd08517 114615011108 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 114615011109 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 114615011110 dimer interface [polypeptide binding]; other site 114615011111 conserved gate region; other site 114615011112 putative PBP binding loops; other site 114615011113 ABC-ATPase subunit interface; other site 114615011114 nickel ABC transporter, permease subunit NikC; Region: nickel_nikC; TIGR02790 114615011115 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 114615011116 dimer interface [polypeptide binding]; other site 114615011117 conserved gate region; other site 114615011118 putative PBP binding loops; other site 114615011119 ABC-ATPase subunit interface; other site 114615011120 ATPase components of various ABC-type transport systems, contain duplicated ATPase [General function prediction only]; Region: COG1123 114615011121 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 114615011122 Walker A/P-loop; other site 114615011123 ATP binding site [chemical binding]; other site 114615011124 Q-loop/lid; other site 114615011125 ABC transporter signature motif; other site 114615011126 Walker B; other site 114615011127 D-loop; other site 114615011128 H-loop/switch region; other site 114615011129 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 114615011130 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 114615011131 Walker A/P-loop; other site 114615011132 ATP binding site [chemical binding]; other site 114615011133 Q-loop/lid; other site 114615011134 ABC transporter signature motif; other site 114615011135 Walker B; other site 114615011136 D-loop; other site 114615011137 H-loop/switch region; other site 114615011138 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 114615011139 putative aminophosphonate oxidoreductase; Region: Phn_aa_oxid; TIGR03329 114615011140 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 114615011141 Glyoxalase-like domain; Region: Glyoxalase_3; pfam13468 114615011142 CDP-6-deoxy-delta-3,4-glucoseen reductase; Validated; Region: PRK07609 114615011143 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 114615011144 catalytic loop [active] 114615011145 iron binding site [ion binding]; other site 114615011146 Iron-sulfur binding ferredoxin reductase (FNR) proteins combine the FAD and NAD(P) binding regions of FNR with an N-terminal Iron-Sulfur binding cluster domain. Ferredoxin-NADP+ (oxido)reductase is an FAD-containing enzyme that catalyzes the reversible...; Region: FNR_N-term_Iron_sulfur_binding; cd06194 114615011147 FAD binding pocket [chemical binding]; other site 114615011148 FAD binding motif [chemical binding]; other site 114615011149 phosphate binding motif [ion binding]; other site 114615011150 beta-alpha-beta structure motif; other site 114615011151 NAD binding pocket [chemical binding]; other site 114615011152 Cytochrome b(N-terminal)/b6/petB; Region: Cytochrom_B_N; pfam00033 114615011153 DOMON-like domain of an uncharacterized protein family; Region: DOMON_like_cytochrome; cd09625 114615011154 putative ligand binding site [chemical binding]; other site 114615011155 ABC-type protease/lipase transport system, ATPase and permease components [General function prediction only]; Region: ArpD; COG4618 114615011156 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 114615011157 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 114615011158 Walker A/P-loop; other site 114615011159 ATP binding site [chemical binding]; other site 114615011160 Q-loop/lid; other site 114615011161 ABC transporter signature motif; other site 114615011162 Walker B; other site 114615011163 D-loop; other site 114615011164 H-loop/switch region; other site 114615011165 type I secretion membrane fusion protein, HlyD family; Region: type_I_hlyD; TIGR01843 114615011166 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 114615011167 HlyD family secretion protein; Region: HlyD_3; pfam13437 114615011168 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 114615011169 Tetratricopeptide repeat; Region: TPR_12; pfam13424 114615011170 Tetratricopeptide repeat; Region: TPR_12; pfam13424 114615011171 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 114615011172 TPR motif; other site 114615011173 Tetratricopeptide repeat; Region: TPR_12; pfam13424 114615011174 binding surface 114615011175 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 114615011176 binding surface 114615011177 TPR motif; other site 114615011178 FOG: TPR repeat [General function prediction only]; Region: NrfG; COG0457 114615011179 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 114615011180 TPR motif; other site 114615011181 binding surface 114615011182 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 114615011183 binding surface 114615011184 TPR motif; other site 114615011185 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 114615011186 binding surface 114615011187 TPR motif; other site 114615011188 Sulfotransferase domain; Region: Sulfotransfer_1; pfam00685 114615011189 FOG: TPR repeat [General function prediction only]; Region: NrfG; COG0457 114615011190 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 114615011191 binding surface 114615011192 TPR motif; other site 114615011193 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 114615011194 binding surface 114615011195 TPR motif; other site 114615011196 Tetratricopeptide repeat; Region: TPR_12; pfam13424 114615011197 Sulfotransferase domain; Region: Sulfotransfer_1; pfam00685 114615011198 Formyl transferase catalytic core domain found in a group of proteins with unknown functions; Region: FMT_core_like_2; cd08822 114615011199 putative active site [active] 114615011200 putative substrate binding site [chemical binding]; other site 114615011201 putative cosubstrate binding site; other site 114615011202 catalytic site [active] 114615011203 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 114615011204 EamA-like transporter family; Region: EamA; pfam00892 114615011205 Uncharacterized protein containing caspase domain [General function prediction only]; Region: COG4249 114615011206 Caspase domain; Region: Peptidase_C14; pfam00656 114615011207 active site 114615011208 substrate pocket [chemical binding]; other site 114615011209 proteolytic cleavage site; other site 114615011210 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 114615011211 Uncharacterized protein containing caspase domain [General function prediction only]; Region: COG4249 114615011212 Caspase domain; Region: Peptidase_C14; pfam00656 114615011213 active site 114615011214 substrate pocket [chemical binding]; other site 114615011215 proteolytic cleavage site; other site 114615011216 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 114615011217 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 114615011218 PAS domain; Region: PAS; smart00091 114615011219 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 114615011220 dimer interface [polypeptide binding]; other site 114615011221 phosphorylation site [posttranslational modification] 114615011222 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 114615011223 ATP binding site [chemical binding]; other site 114615011224 Mg2+ binding site [ion binding]; other site 114615011225 G-X-G motif; other site 114615011226 Response regulator receiver domain; Region: Response_reg; pfam00072 114615011227 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 114615011228 active site 114615011229 phosphorylation site [posttranslational modification] 114615011230 intermolecular recognition site; other site 114615011231 dimerization interface [polypeptide binding]; other site 114615011232 circadian clock protein KaiC; Reviewed; Region: PRK09302 114615011233 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 114615011234 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 114615011235 Walker A motif; other site 114615011236 Walker A motif; other site 114615011237 ATP binding site [chemical binding]; other site 114615011238 Walker B motif; other site 114615011239 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 114615011240 Walker A motif; other site 114615011241 ATP binding site [chemical binding]; other site 114615011242 Walker B motif; other site 114615011243 KaiB-like family; composed of the circadian clock proteins, KaiB and the N-terminal KaiB-like sensory domain of SasA. KaiB is an essential protein in maintaining circadian rhythm. It was originally discovered from the cyanobacterium Synechococcus as part...; Region: KaiB_like; cd02978 114615011244 tetramer interface [polypeptide binding]; other site 114615011245 dimer interface [polypeptide binding]; other site 114615011246 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 114615011247 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 114615011248 active site 114615011249 phosphorylation site [posttranslational modification] 114615011250 intermolecular recognition site; other site 114615011251 Domain of unknown function (DUF4415); Region: DUF4415; pfam14384 114615011252 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 114615011253 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 114615011254 dimer interface [polypeptide binding]; other site 114615011255 pyridoxal 5'-phosphate binding site [chemical binding]; other site 114615011256 catalytic residue [active] 114615011257 queuine tRNA-ribosyltransferase; Provisional; Region: tgt; PRK00112 114615011258 Queuine/archaeosine tRNA-ribosyltransferase [Translation, ribosomal structure and biogenesis]; Region: Tgt; COG0343 114615011259 aspartate-semialdehyde dehydrogenase; Provisional; Region: PRK14874 114615011260 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 114615011261 S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Provisional; Region: queA; PRK00147 114615011262 S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Region: queA; TIGR00113 114615011263 cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the...; Region: cyclophilin; cd00317 114615011264 active site 114615011265 cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the...; Region: cyclophilin; cd00317 114615011266 active site 114615011267 phosphopantetheine adenylyltransferase; Provisional; Region: coaD; PRK00168 114615011268 Phosphopantetheine adenylyltransferase; Region: PPAT; cd02163 114615011269 active site 114615011270 (T/H)XGH motif; other site 114615011271 DNA gyrase subunit A; Validated; Region: PRK05560 114615011272 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187 114615011273 CAP-like domain; other site 114615011274 active site 114615011275 primary dimer interface [polypeptide binding]; other site 114615011276 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 114615011277 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 114615011278 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 114615011279 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 114615011280 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 114615011281 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 114615011282 Transcriptional regulator [Transcription]; Region: LysR; COG0583 114615011283 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 114615011284 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_5; cd08474 114615011285 putative effector binding pocket; other site 114615011286 putative dimerization interface [polypeptide binding]; other site 114615011287 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 114615011288 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 114615011289 active site 114615011290 catalytic tetrad [active] 114615011291 Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629 114615011292 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 114615011293 dimer interface [polypeptide binding]; other site 114615011294 ssDNA binding site [nucleotide binding]; other site 114615011295 tetramer (dimer of dimers) interface [polypeptide binding]; other site 114615011296 Opacity protein and related surface antigens [Cell envelope biogenesis, outer membrane]; Region: COG3637 114615011297 Outer membrane protein beta-barrel domain; Region: OMP_b-brl; pfam13505 114615011298 Opacity protein and related surface antigens [Cell envelope biogenesis, outer membrane]; Region: COG3637 114615011299 Opacity protein and related surface antigens [Cell envelope biogenesis, outer membrane]; Region: COG3637 114615011300 Opacity protein and related surface antigens [Cell envelope biogenesis, outer membrane]; Region: COG3637 114615011301 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 114615011302 excinuclease ABC subunit A; Reviewed; Region: uvrA; PRK00349 114615011303 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 114615011304 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 114615011305 ATP-binding cassette domain II of the excision repair protein UvrA; Region: ABC_UvrA_II; cd03271 114615011306 Predicted phosphatases [General function prediction only]; Region: Gph; COG0546 114615011307 PQQ-dependent catabolism-associated beta-propeller protein; Region: PQQ_ABC_repeats; TIGR03866 114615011308 40-residue YVTN family beta-propeller repeat; Region: beta_rpt_yvtn; TIGR02276 114615011309 40-residue YVTN family beta-propeller repeat; Region: beta_rpt_yvtn; TIGR02276 114615011310 40-residue YVTN family beta-propeller repeat; Region: beta_rpt_yvtn; TIGR02276 114615011311 40-residue YVTN family beta-propeller repeat; Region: beta_rpt_yvtn; TIGR02276 114615011312 40-residue YVTN family beta-propeller repeat; Region: beta_rpt_yvtn; TIGR02276 114615011313 40-residue YVTN family beta-propeller repeat; Region: beta_rpt_yvtn; TIGR02276 114615011314 Pyrabactin resistance 1 (PYR1), PYR1-like (PYL), regulatory component of abscisic acid receptors (RCARs), and related proteins; Region: PYR_PYL_RCAR_like; cd07821 114615011315 putative hydrophobic ligand binding site [chemical binding]; other site 114615011316 protein interface [polypeptide binding]; other site 114615011317 gate; other site 114615011318 Uncharacterized protein family (UPF0149); Region: UPF0149; pfam03695 114615011319 SEC-C motif; Region: SEC-C; pfam02810 114615011320 Predicted ATPase [General function prediction only]; Region: COG3910 114615011321 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 114615011322 Walker A/P-loop; other site 114615011323 ATP binding site [chemical binding]; other site 114615011324 Q-loop/lid; other site 114615011325 ABC transporter signature motif; other site 114615011326 Walker B; other site 114615011327 D-loop; other site 114615011328 H-loop/switch region; other site 114615011329 Domain of unknown function found in archaea, bacteria, and plants; Region: DUF296; cl00720 114615011330 acyl-CoA synthetase; Validated; Region: PRK07470 114615011331 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 114615011332 Bacterial Bile acid CoA ligases and similar proteins; Region: BACL_like; cd05929 114615011333 acyl-activating enzyme (AAE) consensus motif; other site 114615011334 acyl-activating enzyme (AAE) consensus motif; other site 114615011335 putative AMP binding site [chemical binding]; other site 114615011336 putative active site [active] 114615011337 putative CoA binding site [chemical binding]; other site 114615011338 Predicted acetyltransferase [General function prediction only]; Region: COG2388 114615011339 Domain of unknown function (DUF1127); Region: DUF1127; pfam06568 114615011340 Domain of unknown function (DUF3597); Region: DUF3597; pfam12200 114615011341 Predicted integral membrane protein (DUF2189); Region: DUF2189; cl02291 114615011342 lytic murein transglycosylase; Region: MltB_2; TIGR02283 114615011343 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 114615011344 N-acetyl-D-glucosamine binding site [chemical binding]; other site 114615011345 Domain of unknown function (DUF1127); Region: DUF1127; pfam06568 114615011346 tRNA (uracil-5-)-methyltransferase Gid; Reviewed; Region: PRK05335 114615011347 Glucose inhibited division protein A; Region: GIDA; pfam01134 114615011348 serine/threonine protein kinase; Provisional; Region: PRK09188 114615011349 serine/threonine protein kinase; Provisional; Region: PRK12274 114615011350 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 114615011351 Taurine catabolism dioxygenase TauD, TfdA family; Region: TauD; pfam02668 114615011352 Probable taurine catabolism dioxygenase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: TauD; COG2175 114615011353 active site 114615011354 iron coordination sites [ion binding]; other site 114615011355 substrate binding pocket [chemical binding]; other site 114615011356 Probable taurine catabolism dioxygenase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: TauD; COG2175 114615011357 Taurine catabolism dioxygenase TauD, TfdA family; Region: TauD; pfam02668 114615011358 Squalene/phytoene synthase; Region: SQS_PSY; pfam00494 114615011359 substrate binding pocket [chemical binding]; other site 114615011360 substrate-Mg2+ binding site; other site 114615011361 aspartate-rich region 1; other site 114615011362 aspartate-rich region 2; other site 114615011363 Mth938-like domain. The members of this family include: Mth938, 2P1, Xcr35, Rpa2829, and several uncharacterized sequences. Mth938 is a hypothetical protein encoded by the Methanobacterium thermoautotrophicum (Mth) genome. This protein crystallizes as a...; Region: Mth938-like; cd00248 114615011364 preprotein translocase subunit SecF; Reviewed; Region: secF; PRK13022 114615011365 SecD/SecF GG Motif; Region: Sec_GG; pfam07549 114615011366 Protein export membrane protein; Region: SecD_SecF; pfam02355 114615011367 preprotein translocase subunit SecD; Reviewed; Region: secD; PRK05812 114615011368 SecD/SecF GG Motif; Region: Sec_GG; pfam07549 114615011369 protein-export membrane protein, SecD/SecF family; Region: 2A0604s01; TIGR00916 114615011370 preprotein translocase subunit YajC; Validated; Region: yajC; PRK05585 114615011371 Predicted ATPase (AAA+ superfamily) [General function prediction only]; Region: COG2607 114615011372 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 114615011373 Walker A motif; other site 114615011374 ATP binding site [chemical binding]; other site 114615011375 Walker B motif; other site 114615011376 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 114615011377 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 114615011378 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 114615011379 Peptidase family M23; Region: Peptidase_M23; pfam01551 114615011380 protein-L-isoaspartate O-methyltransferase; Reviewed; Region: pcm; PRK00312 114615011381 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 114615011382 S-adenosylmethionine binding site [chemical binding]; other site 114615011383 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 114615011384 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 114615011385 active site 114615011386 phosphorylation site [posttranslational modification] 114615011387 intermolecular recognition site; other site 114615011388 dimerization interface [polypeptide binding]; other site 114615011389 5'(3')-nucleotidase/polyphosphatase; Provisional; Region: surE; PRK00346 114615011390 seryl-tRNA synthetase; Provisional; Region: PRK05431 114615011391 Seryl-tRNA synthetase N-terminal domain; Region: Seryl_tRNA_N; pfam02403 114615011392 Seryl-tRNA synthetase (SerRS) class II core catalytic domain. SerRS is responsible for the attachment of serine to the 3' OH group of ribose of the appropriate tRNA. This domain It is primarily responsible for ATP-dependent formation of the enzyme...; Region: SerRS_core; cd00770 114615011393 dimer interface [polypeptide binding]; other site 114615011394 active site 114615011395 motif 1; other site 114615011396 motif 2; other site 114615011397 motif 3; other site 114615011398 Sec-independent protein secretion pathway component TatC [Intracellular trafficking and secretion]; Region: TatC; COG0805 114615011399 twin arginine-targeting protein translocase TatB; Region: tatB; TIGR01410 114615011400 twin arginine translocase protein A; Provisional; Region: tatA; PRK00720 114615011401 twin arginine translocase protein A; Provisional; Region: tatA; PRK00575 114615011402 Putative transcriptional regulators (Ypuh-like); Region: DUF387; pfam04079 114615011403 Rec8/ScpA/Scc1-like protein (kleisin family) [Replication, recombination, and repair]; Region: scpA; COG1354 114615011404 Beta-glucosidase-related glycosidases [Carbohydrate transport and metabolism]; Region: BglX; COG1472 114615011405 Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; cl07971 114615011406 Sporulation related domain; Region: SPOR; pfam05036 114615011407 arginyl-tRNA synthetase; Reviewed; Region: argS; PRK01611 114615011408 Arginyl tRNA synthetase N terminal dom; Region: Arg_tRNA_synt_N; smart01016 114615011409 catalytic core domain of arginyl-tRNA synthetases; Region: ArgRS_core; cd00671 114615011410 active site 114615011411 HIGH motif; other site 114615011412 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 114615011413 KMSK motif region; other site 114615011414 tRNA binding surface [nucleotide binding]; other site 114615011415 DALR anticodon binding domain; Region: DALR_1; smart00836 114615011416 anticodon binding site; other site 114615011417 deoxyguanosinetriphosphate triphosphohydrolase-like protein; Provisional; Region: PRK01286 114615011418 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 114615011419 Zn2+ binding site [ion binding]; other site 114615011420 Mg2+ binding site [ion binding]; other site 114615011421 Phosphohydrolase-associated domain; Region: HD_assoc; pfam13286 114615011422 Fe-S cluster assembly scaffold protein [Posttranslational modification, protein turnover, chaperones]; Region: sufA; COG0316 114615011423 PAS domain; Region: PAS_9; pfam13426 114615011424 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 114615011425 dimer interface [polypeptide binding]; other site 114615011426 phosphorylation site [posttranslational modification] 114615011427 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 114615011428 ATP binding site [chemical binding]; other site 114615011429 Mg2+ binding site [ion binding]; other site 114615011430 G-X-G motif; other site 114615011431 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 114615011432 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 114615011433 active site 114615011434 phosphorylation site [posttranslational modification] 114615011435 intermolecular recognition site; other site 114615011436 dimerization interface [polypeptide binding]; other site 114615011437 Calcineurin-like phosphoesterase superfamily domain; Region: Metallophos_2; pfam12850 114615011438 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 114615011439 active site 114615011440 metal binding site [ion binding]; metal-binding site 114615011441 Transcriptional regulator [Transcription]; Region: LysR; COG0583 114615011442 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 114615011443 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 114615011444 putative effector binding pocket; other site 114615011445 dimerization interface [polypeptide binding]; other site 114615011446 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases [Coenzyme metabolism / Energy production and conversion]; Region: UbiH; COG0654 114615011447 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 114615011448 Flavin reductase like domain; Region: Flavin_Reduct; smart00903 114615011449 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 114615011450 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 114615011451 active site 114615011452 catalytic tetrad [active] 114615011453 Escherichia coli exonuclease III (ExoIII) and Neisseria meningitides NExo-like subfamily of the ExoIII family purinic/apyrimidinic (AP) endonucleases; Region: ExoIII-like_AP-endo; cd09086 114615011454 putative catalytic site [active] 114615011455 putative phosphate binding site [ion binding]; other site 114615011456 active site 114615011457 metal binding site A [ion binding]; metal-binding site 114615011458 DNA binding site [nucleotide binding] 114615011459 putative AP binding site [nucleotide binding]; other site 114615011460 putative metal binding site B [ion binding]; other site 114615011461 beta-lactamase TEM; Provisional; Region: PRK15442 114615011462 Beta-lactamase enzyme family; Region: Beta-lactamase2; pfam13354 114615011463 UreD urease accessory protein; Region: UreD; pfam01774 114615011464 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 114615011465 urease subunit alpha; Reviewed; Region: ureC; PRK13308 114615011466 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 114615011467 active site 114615011468 bifunctional urease subunit gamma/beta; Reviewed; Region: PRK13192 114615011469 Urease gamma-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, archaea, fungi and plants. Their primary role is to allow the use...; Region: Urease_gamma; cd00390 114615011470 alpha-gamma subunit interface [polypeptide binding]; other site 114615011471 beta-gamma subunit interface [polypeptide binding]; other site 114615011472 Urease beta-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, archaea, fungi and plants. Their primary role is to allow the use of...; Region: Urease_beta; cd00407 114615011473 gamma-beta subunit interface [polypeptide binding]; other site 114615011474 alpha-beta subunit interface [polypeptide binding]; other site 114615011475 Urease accessory protein UreF [Posttranslational modification, protein turnover, chaperones]; Region: UreF; COG0830 114615011476 UreF; Region: UreF; pfam01730 114615011477 urease accessory protein UreE; Provisional; Region: ureE; PRK13261 114615011478 UreE urease accessory protein. UreE is a metallochaperone assisting the insertion of a Ni2+ ion in the active site of urease, an important step in the in vivo assembly of urease, an enzyme that hydrolyses urea into ammonia and carbamic acid. The...; Region: UreE; cl03727 114615011479 dimer interface [polypeptide binding]; other site 114615011480 catalytic residues [active] 114615011481 Uncharacterized conserved protein [Function unknown]; Region: COG1359 114615011482 amidase; Provisional; Region: PRK07235 114615011483 Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154 114615011484 ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224 114615011485 urea ABC transporter, ATP-binding protein UrtE; Region: urea_trans_UrtE; TIGR03410 114615011486 Walker A/P-loop; other site 114615011487 ATP binding site [chemical binding]; other site 114615011488 Q-loop/lid; other site 114615011489 ABC transporter signature motif; other site 114615011490 Walker B; other site 114615011491 D-loop; other site 114615011492 H-loop/switch region; other site 114615011493 urea ABC transporter, ATP-binding protein UrtD; Region: urea_trans_UrtD; TIGR03411 114615011494 ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219 114615011495 Walker A/P-loop; other site 114615011496 ATP binding site [chemical binding]; other site 114615011497 Q-loop/lid; other site 114615011498 ABC transporter signature motif; other site 114615011499 Walker B; other site 114615011500 D-loop; other site 114615011501 H-loop/switch region; other site 114615011502 ABC-type branched-chain amino acid transport system, permease component [Amino acid transport and metabolism]; Region: LivM; COG4177 114615011503 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 114615011504 TM-ABC transporter signature motif; other site 114615011505 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 114615011506 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 114615011507 TM-ABC transporter signature motif; other site 114615011508 Periplasmic binding protein; Region: Peripla_BP_6; pfam13458 114615011509 Periplasmic component (FmdD) of an active transport system for short-chain amides and urea (FmdDEF); Region: PBP1_Amide_Urea_BP_like; cd06356 114615011510 putative ligand binding site [chemical binding]; other site 114615011511 Type I periplasmic-binding protein of the nitrile hydratase (NHase) system that selectively converts nitriles to corresponding amides; Region: PBP1_NHase; cd06358 114615011512 Periplasmic binding protein; Region: Peripla_BP_6; pfam13458 114615011513 putative ligand binding site [chemical binding]; other site 114615011514 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 114615011515 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 114615011516 Coenzyme A binding pocket [chemical binding]; other site 114615011517 FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790 114615011518 Sel1-like repeats; Region: SEL1; smart00671 114615011519 dihydroxy-acid dehydratase; Provisional; Region: PRK00911 114615011520 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3181 114615011521 threonine synthase; Validated; Region: PRK08197 114615011522 Threonine synthase is a pyridoxal phosphate (PLP) dependent enzyme that catalyses the last reaction in the synthesis of threonine from aspartate. It proceeds by converting O-phospho-L-homoserine (OPH) into threonine and inorganic phosphate. In plants; Region: Thr-synth_1; cd01563 114615011523 homodimer interface [polypeptide binding]; other site 114615011524 pyridoxal 5'-phosphate binding site [chemical binding]; other site 114615011525 catalytic residue [active] 114615011526 dihydrolipoamide dehydrogenase; Reviewed; Region: PRK06416 114615011527 Anaerobic glycerol-3-phosphate dehydrogenase [Amino acid transport and metabolism]; Region: GlpB; cl17730 114615011528 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 114615011529 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 114615011530 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 114615011531 pyruvate dehydrogenase complex dihydrolipoamide acetyltransferase, long form; Region: PDHac_trf_mito; TIGR01349 114615011532 E3 interaction surface; other site 114615011533 lipoyl attachment site [posttranslational modification]; other site 114615011534 e3 binding domain; Region: E3_binding; pfam02817 114615011535 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 114615011536 pyruvate dehydrogenase subunit beta; Provisional; Region: PRK11892 114615011537 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 114615011538 E3 interaction surface; other site 114615011539 lipoyl attachment site [posttranslational modification]; other site 114615011540 Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036 114615011541 alpha subunit interface [polypeptide binding]; other site 114615011542 TPP binding site [chemical binding]; other site 114615011543 heterodimer interface [polypeptide binding]; other site 114615011544 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 114615011545 pyruvate dehydrogenase E1 component, alpha subunit; Region: PDH_E1_alph_y; TIGR03182 114615011546 Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000 114615011547 tetramer interface [polypeptide binding]; other site 114615011548 TPP-binding site [chemical binding]; other site 114615011549 heterodimer interface [polypeptide binding]; other site 114615011550 phosphorylation loop region [posttranslational modification] 114615011551 Septum formation initiator [Cell division and chromosome partitioning]; Region: COG2919 114615011552 Septum formation initiator; Region: DivIC; pfam04977 114615011553 hypothetical protein; Provisional; Region: PRK06486 114615011554 intersubunit interface [polypeptide binding]; other site 114615011555 active site 114615011556 Zn2+ binding site [ion binding]; other site 114615011557 Predicted flavoprotein [General function prediction only]; Region: COG0431 114615011558 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 114615011559 Beta-lactamase; Region: Beta-lactamase; pfam00144 114615011560 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 114615011561 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 114615011562 2-enoyl thioester reductase (ETR) like proteins, child 1; Region: ETR_like_1; cd08291 114615011563 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 114615011564 NADP binding site [chemical binding]; other site 114615011565 dimer interface [polypeptide binding]; other site 114615011566 enolase; Provisional; Region: eno; PRK00077 114615011567 Enolase: Enolases are homodimeric enzymes that catalyse the reversible dehydration of 2-phospho-D-glycerate to phosphoenolpyruvate as part of the glycolytic and gluconeogenesis pathways. The reaction is facilitated by the presence of metal ions; Region: enolase; cd03313 114615011568 dimer interface [polypeptide binding]; other site 114615011569 metal binding site [ion binding]; metal-binding site 114615011570 substrate binding pocket [chemical binding]; other site 114615011571 7-cyano-7-deazaguanine reductase; Provisional; Region: PRK13258 114615011572 putative transposase OrfB; Reviewed; Region: PHA02517 114615011573 HTH-like domain; Region: HTH_21; pfam13276 114615011574 Integrase core domain; Region: rve; pfam00665 114615011575 Integrase core domain; Region: rve_3; pfam13683 114615011576 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 114615011577 Major Facilitator Superfamily; Region: MFS_1; pfam07690 114615011578 putative substrate translocation pore; other site 114615011579 DAHP synthetase I family; Region: DAHP_synth_1; pfam00793 114615011580 2-dehydro-3-deoxyphosphooctonate aldolase; Provisional; Region: PRK05198 114615011581 NIPSNAP; Region: NIPSNAP; pfam07978 114615011582 CTP synthetase; Validated; Region: pyrG; PRK05380 114615011583 CTP synthetase (CTPs) is a two-domain protein, which consists of an N-terminal synthetase domain and C-terminal glutaminase domain. The enzymes hydrolyze the amide bond of glutamine to ammonia and glutamate at the glutaminase domains and transfer nascent...; Region: CTGs; cd03113 114615011584 Catalytic site [active] 114615011585 active site 114615011586 UTP binding site [chemical binding]; other site 114615011587 Type 1 glutamine amidotransferase (GATase1) domain found in Cytidine Triphosphate Synthetase; Region: GATase1_CTP_Synthase; cd01746 114615011588 active site 114615011589 putative oxyanion hole; other site 114615011590 catalytic triad [active] 114615011591 preprotein translocase subunit SecG; Reviewed; Region: secG; PRK06870 114615011592 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 114615011593 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 114615011594 non-specific DNA binding site [nucleotide binding]; other site 114615011595 salt bridge; other site 114615011596 sequence-specific DNA binding site [nucleotide binding]; other site 114615011597 Cupin domain; Region: Cupin_2; pfam07883 114615011598 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 114615011599 Triosephosphate isomerase (TIM) is a glycolytic enzyme that catalyzes the interconversion of dihydroxyacetone phosphate and D-glyceraldehyde-3-phosphate. The reaction is very efficient and requires neither cofactors nor metal ions. TIM, usually...; Region: TIM; cd00311 114615011600 triosephosphate isomerase; Provisional; Region: PRK14565 114615011601 substrate binding site [chemical binding]; other site 114615011602 dimer interface [polypeptide binding]; other site 114615011603 catalytic triad [active] 114615011604 SurA N-terminal domain; Region: SurA_N_3; cl07813 114615011605 Parvulin-like peptidyl-prolyl isomerase [Posttranslational modification, protein turnover, chaperones]; Region: SurA; COG0760 114615011606 PPIC-type PPIASE domain; Region: Rotamase_2; pfam13145 114615011607 PPIC-type PPIASE domain; Region: Rotamase_2; pfam13145 114615011608 anthranilate phosphoribosyltransferase; Provisional; Region: trpD; PRK00188 114615011609 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 114615011610 Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591 114615011611 Indole-3-glycerol phosphate synthase (IGPS); an enzyme in the tryptophan biosynthetic pathway, catalyzing the ring closure reaction of 1-(o-carboxyphenylamino)-1-deoxyribulose-5-phosphate (CdRP) to indole-3-glycerol phosphate (IGP), accompanied by the...; Region: IGPS; cd00331 114615011612 active site 114615011613 ribulose/triose binding site [chemical binding]; other site 114615011614 phosphate binding site [ion binding]; other site 114615011615 substrate (anthranilate) binding pocket [chemical binding]; other site 114615011616 product (indole) binding pocket [chemical binding]; other site 114615011617 MoaC family, prokaryotic and eukaryotic. Members of this family are involved in molybdenum cofactor (Moco) biosynthesis, an essential cofactor of a diverse group of redox enzymes. MoaC, a small hexameric protein, converts, together with MoaA, a guanosine...; Region: MoaC_PE; cd01420 114615011618 trimer interface [polypeptide binding]; other site 114615011619 dimer interface [polypeptide binding]; other site 114615011620 putative active site [active] 114615011621 PAS fold; Region: PAS_7; pfam12860 114615011622 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 114615011623 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 114615011624 metal binding site [ion binding]; metal-binding site 114615011625 active site 114615011626 I-site; other site 114615011627 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 114615011628 Periplasmic protease [Cell envelope biogenesis, outer membrane]; Region: Prc; COG0793 114615011629 C-terminal processing peptidase family S41; Region: Peptidase_S41; cl02526 114615011630 PDZ domain of C-terminal processing-, tail-specific-, and tricorn proteases, which function in posttranslational protein processing, maturation, and disassembly or degradation, in Bacteria, Archaea, and plant chloroplasts. May be responsible for...; Region: PDZ_CTP_protease; cd00988 114615011631 protein binding site [polypeptide binding]; other site 114615011632 C-terminal processing peptidase; serine protease family S41; Region: Peptidase_S41_CPP; cd07560 114615011633 Catalytic dyad [active] 114615011634 Family of homologous FMN-dependent alpha-hydroxyacid oxidizing enzymes. This family occurs in both prokaryotes and eukaryotes. Members of this family include flavocytochrome b2 (FCB2), glycolate oxidase (GOX), lactate monooxygenase (LMO), mandelate...; Region: alpha_hydroxyacid_oxid_FMN; cd02809 114615011635 FMN-dependent dehydrogenase; Region: FMN_dh; pfam01070 114615011636 active site 114615011637 substrate binding site [chemical binding]; other site 114615011638 FMN binding site [chemical binding]; other site 114615011639 putative catalytic residues [active] 114615011640 Haloacid dehalogenase-like hydrolase; Region: HAD_2; pfam13419 114615011641 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 114615011642 motif II; other site 114615011643 TfoX N-terminal domain; Region: TfoX_N; pfam04993 114615011644 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 114615011645 Novel bacterial esterase that cleaves esters on halogenated cyclic compounds; Region: Esterase_713_like; cl17303 114615011646 catalytic site [active] 114615011647 Molybdopterin biosynthesis enzyme [Coenzyme metabolism]; Region: MoeA; COG0303 114615011648 MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoeA; cd00887 114615011649 dimer interface [polypeptide binding]; other site 114615011650 putative functional site; other site 114615011651 putative MPT binding site; other site 114615011652 LexA repressor; Validated; Region: PRK00215 114615011653 LexA DNA binding domain; Region: LexA_DNA_bind; pfam01726 114615011654 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 114615011655 Catalytic site [active] 114615011656 Domain of unknown function (DUF4131); Region: DUF4131; pfam13567 114615011657 Predicted membrane metal-binding protein [General function prediction only]; Region: ComEC; COG0658 114615011658 Competence protein; Region: Competence; pfam03772 114615011659 glutaminyl-tRNA synthetase; Provisional; Region: PRK05347 114615011660 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 114615011661 active site 114615011662 HIGH motif; other site 114615011663 nucleotide binding site [chemical binding]; other site 114615011664 catalytic core domain of glutaminyl-tRNA synthetase; Region: GlnRS_core; cd00807 114615011665 KMSKS motif; other site 114615011666 tRNA synthetases class I (E and Q), anti-codon binding domain; Region: tRNA-synt_1c_C; pfam03950 114615011667 glutamyl-tRNA synthetase; Reviewed; Region: gltX; PRK01406 114615011668 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 114615011669 HIGH motif; other site 114615011670 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 114615011671 active site 114615011672 KMSKS motif; other site 114615011673 Escherichia coli (Ec) citrate synthase (CS) GltA_like. CS catalyzes the condensation of acetyl coenzyme A (AcCoA) and oxalacetate (OAA) to form citrate and coenzyme A (CoA), the first step in the citric acid cycle (TCA or Krebs cycle). The overall CS...; Region: EcCS_like; cd06114 114615011674 Citrate synthase [Energy production and conversion]; Region: GltA; COG0372 114615011675 dimer interface [polypeptide binding]; other site 114615011676 active site 114615011677 citrylCoA binding site [chemical binding]; other site 114615011678 NADH binding [chemical binding]; other site 114615011679 cationic pore residues; other site 114615011680 oxalacetate/citrate binding site [chemical binding]; other site 114615011681 coenzyme A binding site [chemical binding]; other site 114615011682 catalytic triad [active] 114615011683 lipid-A-disaccharide synthase; Reviewed; Region: lpxB; PRK00025 114615011684 ipid-A-disaccharide synthase; Provisional; Region: PRK14089 114615011685 Protein of unknown function (DUF1009); Region: DUF1009; pfam06230 114615011686 UDP-N-acetylglucosamine acyltransferase; Provisional; Region: PRK05289 114615011687 UDP-N-acetylglucosamine O-acyltransferase (UDP-GlcNAc acyltransferase): Proteins in this family catalyze the transfer of (R)-3-hydroxymyristic acid from its acyl carrier protein thioester to UDP-GlcNAc. It is the first enzyme in the lipid A biosynthetic...; Region: LbH_UDP-GlcNAc_AT; cd03351 114615011688 active site 114615011689 FabZ is a 17kD beta-hydroxyacyl-acyl carrier protein (ACP) dehydratase that primarily catalyzes the dehydration of beta-hydroxyacyl-ACP to trans-2-acyl-ACP, the third step in the elongation phase of the bacterial/ plastid, type II, fatty-acid...; Region: FabZ; cd01288 114615011690 UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase; Region: lipid_A_lpxD; TIGR01853 114615011691 UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase, LpxD; Region: LpxD; pfam04613 114615011692 UDP-3-O-acyl-glucosamine N-acyltransferase (LpxD): The enzyme catalyzes the transfer of 3-hydroxymyristic acid or 3-hydroxy-arachidic acid, depending on the organism, from the acyl carrier protein (ACP) to UDP-3-O-acyl-glucosamine to produce UDP-2; Region: LbH_LpxD; cd03352 114615011693 trimer interface [polypeptide binding]; other site 114615011694 active site 114615011695 UDP-GlcNAc binding site [chemical binding]; other site 114615011696 lipid binding site [chemical binding]; lipid-binding site 114615011697 outer membrane protein assembly complex, YaeT protein; Region: OM_YaeT; TIGR03303 114615011698 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 114615011699 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 114615011700 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 114615011701 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 114615011702 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 114615011703 Surface antigen; Region: Bac_surface_Ag; pfam01103 114615011704 Predicted membrane-associated Zn-dependent proteases 1 [Cell envelope biogenesis, outer membrane]; Region: COG0750 114615011705 RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163 114615011706 active site 114615011707 PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989 114615011708 protein binding site [polypeptide binding]; other site 114615011709 RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163 114615011710 putative substrate binding region [chemical binding]; other site 114615011711 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Provisional; Region: PRK05447 114615011712 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Region: DXP_reductoisom; pfam02670 114615011713 1-deoxy-D-xylulose 5-phosphate reductoisomerase C-terminal; Region: DXP_redisom_C; pfam08436 114615011714 DXP reductoisomerase C-terminal domain; Region: DXPR_C; pfam13288 114615011715 Cytidylyltransferase family; Region: CTP_transf_1; pfam01148 114615011716 CDP-diglyceride synthetase [Lipid metabolism]; Region: CdsA; COG0575 114615011717 Cis (Z)-Isoprenyl Diphosphate Synthases (cis-IPPS); homodimers which catalyze the successive 1'-4 condensation of the isopentenyl diphosphate (IPP) molecule to trans,trans-farnesyl diphosphate (FPP) or to cis,trans-FPP to form long-chain polyprenyl...; Region: CIS_IPPS; cl00230 114615011718 undecaprenyl pyrophosphate synthase; Provisional; Region: PRK14834 114615011719 catalytic residue [active] 114615011720 putative FPP diphosphate binding site; other site 114615011721 putative FPP binding hydrophobic cleft; other site 114615011722 dimer interface [polypeptide binding]; other site 114615011723 putative IPP diphosphate binding site; other site 114615011724 ribosome recycling factor; Reviewed; Region: frr; PRK00083 114615011725 Ribosome recycling factor (RRF). Ribosome recycling factor dissociates the posttermination complex, composed of the ribosome, deacylated tRNA, and mRNA, after termination of translation. Thus ribosomes are "recycled" and ready for another...; Region: RRF; cd00520 114615011726 hinge region; other site 114615011727 UMP kinase (UMPK)-Ec, the microbial/chloroplast uridine monophosphate kinase (uridylate kinase) enzyme that catalyzes UMP phosphorylation and plays a key role in pyrimidine nucleotide biosynthesis; regulation of this process is via feed-back control and...; Region: AAK_UMPK-PyrH-Ec; cd04254 114615011728 putative nucleotide binding site [chemical binding]; other site 114615011729 uridine monophosphate binding site [chemical binding]; other site 114615011730 homohexameric interface [polypeptide binding]; other site 114615011731 elongation factor Ts; Provisional; Region: tsf; PRK09377 114615011732 UBA/TS-N domain; Region: UBA; pfam00627 114615011733 Elongation factor TS; Region: EF_TS; pfam00889 114615011734 Elongation factor TS; Region: EF_TS; pfam00889 114615011735 30S ribosomal protein S2/unknown domain fusion protein; Provisional; Region: rpsB; PRK12311 114615011736 Ribosomal protein S2 (RPS2), involved in formation of the translation initiation complex, where it might contact the messenger RNA and several components of the ribosome. It has been shown that in Escherichia coli RPS2 is essential for the binding of...; Region: RPS2; cd01425 114615011737 rRNA interaction site [nucleotide binding]; other site 114615011738 S8 interaction site; other site 114615011739 putative laminin-1 binding site; other site 114615011740 Uncharacterized conserved protein [Function unknown]; Region: COG3743 114615011741 Protein of unknown function (DUF2846); Region: DUF2846; pfam11008 114615011742 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 114615011743 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 114615011744 phosphopeptide binding site; other site 114615011745 Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]; Region: DegQ; COG0265 114615011746 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 114615011747 Uncharacterized protein containing caspase domain [General function prediction only]; Region: COG4249 114615011748 Caspase domain; Region: Peptidase_C14; pfam00656 114615011749 DNA polymerase III subunit alpha; Validated; Region: dnaE; PRK05673 114615011750 Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III DnaE1; Region: PHP_PolIIIA_DnaE1; cd07433 114615011751 putative active site [active] 114615011752 putative PHP Thumb interface [polypeptide binding]; other site 114615011753 DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485 114615011754 generic binding surface I; other site 114615011755 generic binding surface II; other site 114615011756 Opacity protein and related surface antigens [Cell envelope biogenesis, outer membrane]; Region: COG3637 114615011757 Protein of unknown function (DUF3551); Region: DUF3551; pfam12071 114615011758 Opacity protein and related surface antigens [Cell envelope biogenesis, outer membrane]; Region: COG3637 114615011759 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 114615011760 sequence-specific DNA binding site [nucleotide binding]; other site 114615011761 salt bridge; other site 114615011762 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 114615011763 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cd05188 114615011764 NAD(P) binding site [chemical binding]; other site 114615011765 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 114615011766 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 114615011767 Walker A/P-loop; other site 114615011768 ATP binding site [chemical binding]; other site 114615011769 Q-loop/lid; other site 114615011770 ABC transporter signature motif; other site 114615011771 Walker B; other site 114615011772 D-loop; other site 114615011773 H-loop/switch region; other site 114615011774 lipoprotein releasing system, transmembrane protein, LolC/E family; Region: lolCE; TIGR02212 114615011775 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 114615011776 FtsX-like permease family; Region: FtsX; pfam02687 114615011777 prolyl-tRNA synthetase; Provisional; Region: PRK12325 114615011778 Prolyl-tRNA synthetase (ProRS) class II core catalytic domain. ProRS is a homodimer. It is responsible for the attachment of proline to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ProRS_core_prok; cd00779 114615011779 dimer interface [polypeptide binding]; other site 114615011780 motif 1; other site 114615011781 active site 114615011782 motif 2; other site 114615011783 motif 3; other site 114615011784 ProRS Prolyl-anticodon binding domain, short version found predominantly in bacteria. ProRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding; Region: ProRS_anticodon_short; cd00861 114615011785 anticodon binding site; other site 114615011786 CopC domain; Region: CopC; pfam04234 114615011787 Putative copper export protein [Inorganic ion transport and metabolism]; Region: PcoD; COG1276 114615011788 Reeler-like domain of YcnI and similar proteins; Region: YcnI_like; cd08545 114615011789 Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629 114615011790 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 114615011791 N-terminal plug; other site 114615011792 ligand-binding site [chemical binding]; other site 114615011793 Type 1 glutamine amidotransferase (GATase1)-like domain found in a subgroup of proteins similar to PfpI from Pyrococcus furiosus; Region: GATase1_PfpI_2; cd03139 114615011794 Putative intracellular protease/amidase [General function prediction only]; Region: ThiJ; COG0693 114615011795 conserved cys residue [active] 114615011796 Protein of unknown function (DUF461); Region: DUF461; pfam04314 114615011797 Protein of unknown function (DUF2946); Region: DUF2946; pfam11162 114615011798 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 114615011799 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 114615011800 active site 114615011801 metal binding site [ion binding]; metal-binding site 114615011802 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: RbsB; COG1879 114615011803 Periplasmic sugar-binding domain of uncharacterized ABC-type transport systems; Region: PBP1_ABC_sugar_binding_like_5; cd06313 114615011804 putative ligand binding site [chemical binding]; other site 114615011805 ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129 114615011806 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 114615011807 Walker A/P-loop; other site 114615011808 ATP binding site [chemical binding]; other site 114615011809 Q-loop/lid; other site 114615011810 ABC transporter signature motif; other site 114615011811 Walker B; other site 114615011812 D-loop; other site 114615011813 H-loop/switch region; other site 114615011814 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 114615011815 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 114615011816 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 114615011817 TM-ABC transporter signature motif; other site 114615011818 methylthioribose kinase; Reviewed; Region: mtnK; PRK09550 114615011819 Phosphotransferase enzyme family; Region: APH; pfam01636 114615011820 Protein of unknown function (DUF1467); Region: DUF1467; pfam07330 114615011821 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 114615011822 Methylmalonyl-CoA epimerase (MMCE); Region: MMCE; cd07249 114615011823 dimer interface [polypeptide binding]; other site 114615011824 substrate binding site [chemical binding]; other site 114615011825 metal binding site [ion binding]; metal-binding site 114615011826 mRNA degradation ribonucleases J1/J2 (metallo-beta-lactamase superfamily) [Translation, ribosomal structure and biogenesis; Replication, recombination and repair]; Region: COG0595 114615011827 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 114615011828 RNA-metabolising metallo-beta-lactamase; Region: RMMBL; pfam07521 114615011829 Biotin-(acetyl-CoA carboxylase) ligase [Coenzyme metabolism]; Region: BirA; COG0340 114615011830 Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; pfam03099 114615011831 Biotin protein ligase C terminal domain; Region: BPL_C; pfam02237 114615011832 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 114615011833 NADH dehydrogenase subunit 2; Provisional; Region: ND2; MTH00196 114615011834 NADH:ubiquinone oxidoreductase subunit M; Reviewed; Region: PRK05846 114615011835 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 114615011836 NADH:ubiquinone oxidoreductase subunit L; Reviewed; Region: PRK06590 114615011837 NADH-Ubiquinone oxidoreductase (complex I), chain 5 N-terminus; Region: Oxidored_q1_N; pfam00662 114615011838 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 114615011839 NADH:ubiquinone oxidoreductase subunit K; Validated; Region: PRK05715 114615011840 NADH:ubiquinone oxidoreductase subunit J; Provisional; Region: PRK06638 114615011841 NADH dehydrogenase subunit 6; Provisional; Region: ND6; MTH00213 114615011842 NADH dehydrogenase subunit I; Provisional; Region: PRK05888 114615011843 4Fe-4S binding domain; Region: Fer4; pfam00037 114615011844 4Fe-4S binding domain; Region: Fer4; pfam00037 114615011845 NADH:ubiquinone oxidoreductase subunit H; Provisional; Region: PRK06076 114615011846 NADH dehydrogenase subunit G; Validated; Region: PRK09130 114615011847 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 114615011848 catalytic loop [active] 114615011849 iron binding site [ion binding]; other site 114615011850 NADH-ubiquinone oxidoreductase-G iron-sulfur binding region; Region: NADH-G_4Fe-4S_3; pfam10588 114615011851 MopB_Res_Cmplx1_Nad11: The second domain of the Nad11/75-kDa subunit of the NADH-quinone oxidoreductase/respiratory complex I/NADH dehydrogenase-1(NDH-1) of eukaryotes and the Nqo3/G subunit of alphaproteobacteria NDH-1. The NADH-quinone oxidoreductase...; Region: MopB_Res-Cmplx1_Nad11; cd02773 114615011852 Domain of unknown function (DUF1982); Region: DUF1982; pfam09326 114615011853 NADH dehydrogenase I subunit F; Provisional; Region: PRK13596 114615011854 SLBB domain; Region: SLBB; pfam10531 114615011855 NADH-ubiquinone oxidoreductase-F iron-sulfur binding region; Region: NADH_4Fe-4S; smart00928 114615011856 NADH dehydrogenase subunit E; Validated; Region: PRK07539 114615011857 TRX-like [2Fe-2S] Ferredoxin (Fd) family, NADH:ubiquinone oxidoreductase (Nuo) subunit E subfamily; Nuo, also called respiratory chain Complex 1, is the entry point for electrons into the respiratory chains of bacteria and the mitochondria of eukaryotes; Region: TRX_Fd_NuoE; cd03064 114615011858 putative dimer interface [polypeptide binding]; other site 114615011859 [2Fe-2S] cluster binding site [ion binding]; other site 114615011860 methyltransferase, FkbM family; Region: fkbM_fam; TIGR01444 114615011861 NADH dehydrogenase subunit D; Validated; Region: PRK06075 114615011862 NADH:ubiquinone oxidoreductase 49 kD subunit 7 [Energy production and conversion]; Region: NuoD; COG0649 114615011863 NADH dehydrogenase subunit C; Provisional; Region: PRK06074 114615011864 NADH (or F420H2) dehydrogenase, subunit C; Region: NuoC_fam; TIGR01961 114615011865 NADH dehydrogenase subunit B; Validated; Region: PRK06411 114615011866 NADH:ubiquinone oxidoreductase subunit A; Validated; Region: PRK06602 114615011867 M20 Peptidase T specifically cleaves tripeptides; Region: M20_peptT; cd03892 114615011868 peptidase T; Region: peptidase-T; TIGR01882 114615011869 metal binding site [ion binding]; metal-binding site 114615011870 dimer interface [polypeptide binding]; other site 114615011871 Methyltransferase domain; Region: Methyltransf_23; pfam13489 114615011872 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 114615011873 S-adenosylmethionine binding site [chemical binding]; other site 114615011874 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 114615011875 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 114615011876 active site 114615011877 metal binding site [ion binding]; metal-binding site 114615011878 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 114615011879 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 114615011880 ligand binding site [chemical binding]; other site 114615011881 flexible hinge region; other site 114615011882 ATP-dependent metalloprotease FtsH; Region: FtsH_fam; TIGR01241 114615011883 ATP-dependent Lon protease, bacterial type [Posttranslational modification, protein turnover, chaperones]; Region: Lon; COG0466 114615011884 Found in ATP-dependent protease La (LON); Region: LON; smart00464 114615011885 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 114615011886 Walker A motif; other site 114615011887 ATP binding site [chemical binding]; other site 114615011888 Walker B motif; other site 114615011889 arginine finger; other site 114615011890 Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362 114615011891 ATP-dependent protease ATP-binding subunit ClpX; Provisional; Region: clpX; PRK05342 114615011892 ClpX C4-type zinc finger; Region: zf-C4_ClpX; pfam06689 114615011893 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 114615011894 Walker A motif; other site 114615011895 ATP binding site [chemical binding]; other site 114615011896 Walker B motif; other site 114615011897 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 114615011898 Protease subunit of ATP-dependent Clp proteases [Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: ClpP; COG0740 114615011899 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017 114615011900 oligomer interface [polypeptide binding]; other site 114615011901 active site residues [active] 114615011902 trigger factor; Provisional; Region: tig; PRK01490 114615011903 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 114615011904 Bacterial trigger factor protein (TF) C-terminus; Region: Trigger_C; pfam05698 114615011905 Putative multicopper oxidases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: SufI; COG2132 114615011906 Multicopper oxidase; Region: Cu-oxidase_2; pfam07731 114615011907 L-alanine-DL-glutamate epimerase and related enzymes of enolase superfamily [Cell envelope biogenesis, outer membrane / General function prediction only]; Region: COG4948 114615011908 Enolase-superfamily, characterized by the presence of an enolate anion intermediate which is generated by abstraction of the alpha-proton of the carboxylate substrate by an active site residue and is stabilized by coordination to the essential Mg2+ ion; Region: enolase_like; cl17188 114615011909 metal binding site [ion binding]; metal-binding site 114615011910 substrate binding pocket [chemical binding]; other site 114615011911 Uncharacterized conserved protein [Function unknown]; Region: COG0062 114615011912 putative carbohydrate kinase; Provisional; Region: PRK10565 114615011913 B.subtilis YXKO protein of unknown function and related proteins. Based on the conservation of the ATP binding site, the substrate binding site and the Mg2+binding site and structural homology this group is a member of the ribokinase-like superfamily; Region: YXKO-related; cd01171 114615011914 putative substrate binding site [chemical binding]; other site 114615011915 putative ATP binding site [chemical binding]; other site 114615011916 Nitrogen regulatory protein PII [Amino acid transport and metabolism]; Region: GlnK; COG0347 114615011917 Nitrogen regulatory protein P-II; Region: P-II; smart00938 114615011918 glutamine synthetase; Provisional; Region: glnA; PRK09469 114615011919 Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951 114615011920 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 114615011921 Peptidase C26; Region: Peptidase_C26; pfam07722 114615011922 Subgroup of proteins having the Type 1 glutamine amidotransferase (GATase1) domain; Region: GATase1_2; cd01745 114615011923 catalytic triad [active] 114615011924 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 114615011925 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 114615011926 M20 Peptidase Aminoacylase 1 subfamily; Region: M20_Acy1_like1; cd05666 114615011927 metal binding site [ion binding]; metal-binding site 114615011928 putative dimer interface [polypeptide binding]; other site 114615011929 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 114615011930 metabolite-proton symporter; Region: 2A0106; TIGR00883 114615011931 putative substrate translocation pore; other site 114615011932 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4339 114615011933 Antibiotic biosynthesis monooxygenase; Region: ABM; pfam03992 114615011934 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 114615011935 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 114615011936 metal binding site [ion binding]; metal-binding site 114615011937 active site 114615011938 I-site; other site 114615011939 30S ribosomal protein S9; Reviewed; Region: rpsI; PRK00132 114615011940 Ribosomal protein L13. Protein L13, a large ribosomal subunit protein, is one of five proteins required for an early folding intermediate of 23S rRNA in the assembly of the large subunit. L13 is situated on the bottom of the large subunit, near the...; Region: Ribosomal_L13; cd00392 114615011941 23S rRNA interface [nucleotide binding]; other site 114615011942 L3 interface [polypeptide binding]; other site 114615011943 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 114615011944 CoenzymeA binding site [chemical binding]; other site 114615011945 subunit interaction site [polypeptide binding]; other site 114615011946 PHB binding site; other site 114615011947 enoyl-CoA hydratase; Validated; Region: PRK08139 114615011948 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 114615011949 substrate binding site [chemical binding]; other site 114615011950 oxyanion hole (OAH) forming residues; other site 114615011951 trimer interface [polypeptide binding]; other site 114615011952 Predicted CoA-binding protein [General function prediction only]; Region: COG1832 114615011953 O-acetylhomoserine aminocarboxypropyltransferase; Validated; Region: PRK05994 114615011954 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 114615011955 homodimer interface [polypeptide binding]; other site 114615011956 substrate-cofactor binding pocket; other site 114615011957 pyridoxal 5'-phosphate binding site [chemical binding]; other site 114615011958 catalytic residue [active] 114615011959 Uncharacterized protein required for cytochrome oxidase assembly [Posttranslational modification, protein turnover, chaperones]; Region: CtaA; COG1612 114615011960 Cytochrome oxidase assembly protein; Region: COX15-CtaA; cl15852 114615011961 Protein of unknown function (DUF2842); Region: DUF2842; pfam11003 114615011962 Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726 114615011963 Putative catalytic NodB homology domain of Mesorhizobium loti Mlr8448 protein and its bacterial homologs; Region: CE4_Mlr8448_like_5s; cd10968 114615011964 Putative catalytic NodB homology domain of Mesorhizobium loti Mlr8448 protein and its bacterial homologs; Region: CE4_Mlr8448_like_5s; cd10968 114615011965 putative active site [active] 114615011966 Protein involved in cellulose biosynthesis (CelD) [Cell envelope biogenesis, outer membrane]; Region: COG5653 114615011967 Acetyltransferase (GNAT) domain; Region: Acetyltransf_6; pfam13480 114615011968 Uncharacterized protein involved in exopolysaccharide biosynthesis [Cell envelope biogenesis, outer membrane]; Region: GumC; COG3206 114615011969 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 114615011970 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 114615011971 Undecaprenyl-phosphate glucose phosphotransferase; Region: WcaJ_sugtrans; TIGR03023 114615011972 Sugar transferases involved in lipopolysaccharide synthesis [Cell envelope biogenesis, outer membrane]; Region: WcaJ; COG2148 114615011973 Uncharacterized conserved protein [Function unknown]; Region: COG3268 114615011974 NAD(P) binding domain of amino acid dehydrogenase-like proteins; Region: NAD_bind_amino_acid_DH; cl17226 114615011975 NAD(P) binding pocket [chemical binding]; other site 114615011976 Uncharacterized ArCR, COG2043; Region: DUF169; pfam02596 114615011977 FOG: TPR repeat [General function prediction only]; Region: NrfG; COG0457 114615011978 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 114615011979 TPR motif; other site 114615011980 binding surface 114615011981 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 114615011982 binding surface 114615011983 TPR motif; other site 114615011984 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 114615011985 Uncharacterized conserved protein [Function unknown]; Region: COG1434 114615011986 YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259 114615011987 putative active site [active] 114615011988 Predicted acetamidase/formamidase [Energy production and conversion]; Region: COG2421 114615011989 polyphosphate kinase 2, PA0141 family; Region: PPK2_P_aer; TIGR03707 114615011990 GcrA cell cycle regulator; Region: GcrA; cl11564 114615011991 classical (c) SDRs; Region: SDR_c; cd05233 114615011992 NAD(P) binding site [chemical binding]; other site 114615011993 active site 114615011994 Uncharacterized ABC-type transport system, periplasmic component/surface lipoprotein [General function prediction only]; Region: Med; COG1744 114615011995 Periplasmic binding domain of the basic membrane lipoprotein Med in Bacillus and its close homologs from other bacteria and Archaea; Region: PBP1_BmpA_Med_like; cd06353 114615011996 putative ligand binding site [chemical binding]; other site 114615011997 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 114615011998 Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette; Region: TM_PBP1_transp_TpRbsC_like; cd06580 114615011999 TM-ABC transporter signature motif; other site 114615012000 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 114615012001 Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette; Region: TM_PBP1_transp_TpRbsC_like; cd06580 114615012002 TM-ABC transporter signature motif; other site 114615012003 Isochorismatase family; Region: Isochorismatase; pfam00857 114615012004 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cd00431 114615012005 catalytic triad [active] 114615012006 conserved cis-peptide bond; other site 114615012007 ABC-type uncharacterized transport systems, ATPase components [General function prediction only]; Region: COG3845 114615012008 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 114615012009 Walker A/P-loop; other site 114615012010 ATP binding site [chemical binding]; other site 114615012011 Q-loop/lid; other site 114615012012 ABC transporter signature motif; other site 114615012013 Walker B; other site 114615012014 D-loop; other site 114615012015 H-loop/switch region; other site 114615012016 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 114615012017 myosin-cross-reactive antigen; Provisional; Region: PRK13977 114615012018 myosin-cross-reactive antigen; Provisional; Region: PRK13977 114615012019 Caspase domain; Region: Peptidase_C14; pfam00656 114615012020 Sporulation related domain; Region: SPOR; pfam05036 114615012021 Helix-turn-helix domain; Region: HTH_18; pfam12833 114615012022 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 114615012023 DNA gyrase inhibitor [DNA replication, recombination, and repair]; Region: COG3449 114615012024 Methyltransferase domain; Region: Methyltransf_31; pfam13847 114615012025 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 114615012026 S-adenosylmethionine binding site [chemical binding]; other site 114615012027 RDD family; Region: RDD; pfam06271 114615012028 Integral membrane protein DUF95; Region: DUF95; cl00572 114615012029 Uncharacterized conserved protein (some members contain a von Willebrand factor type A (vWA) domain) [General function prediction only]; Region: COG1721 114615012030 Protein of unknown function DUF58; Region: DUF58; pfam01882 114615012031 MoxR-like ATPases [General function prediction only]; Region: COG0714 114615012032 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 114615012033 Walker A motif; other site 114615012034 ATP binding site [chemical binding]; other site 114615012035 Walker B motif; other site 114615012036 arginine finger; other site 114615012037 PIN (PilT N terminus) domain: Superfamily; Region: PIN_SF; cl14812 114615012038 putative transposase OrfB; Reviewed; Region: PHA02517 114615012039 HTH-like domain; Region: HTH_21; pfam13276 114615012040 Integrase core domain; Region: rve; pfam00665 114615012041 Integrase core domain; Region: rve_3; pfam13683 114615012042 Helix-turn-helix domain; Region: HTH_28; pfam13518 114615012043 Alkanesulfonate monoxygenase is the monoxygenase of a two-component system that catalyzes the conversion of alkanesulfonates to the corresponding aldehyde and sulfite. Alkanesulfonate monoxygenase (SsuD) has an absolute requirement for reduced flavin...; Region: Alkanesulfonate_monoxygenase; cd01094 114615012044 active site 114615012045 dimethyl sulfone monooxygenase SfnG; Region: LLM_DMSO2_sfnG; TIGR04021 114615012046 dimer interface [polypeptide binding]; other site 114615012047 non-prolyl cis peptide bond; other site 114615012048 insertion regions; other site 114615012049 probable oxidoreductase, LLM family; Region: LLM_2I7G; TIGR03858 114615012050 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 114615012051 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 114615012052 dimer interface [polypeptide binding]; other site 114615012053 conserved gate region; other site 114615012054 putative PBP binding loops; other site 114615012055 ABC-ATPase subunit interface; other site 114615012056 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 114615012057 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 114615012058 Walker A/P-loop; other site 114615012059 ATP binding site [chemical binding]; other site 114615012060 Q-loop/lid; other site 114615012061 ABC transporter signature motif; other site 114615012062 Walker B; other site 114615012063 D-loop; other site 114615012064 H-loop/switch region; other site 114615012065 ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components [Inorganic ion transport and metabolism]; Region: TauA; COG0715 114615012066 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 114615012067 substrate binding pocket [chemical binding]; other site 114615012068 membrane-bound complex binding site; other site 114615012069 hinge residues; other site 114615012070 sulfur acquisition oxidoreductase, SfnB family; Region: sulfur_SfnB; TIGR04022 114615012071 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 114615012072 active site 114615012073 Flavin reductase like domain; Region: Flavin_Reduct; smart00903 114615012074 serine O-acetyltransferase; Region: cysE; TIGR01172 114615012075 Serine acetyltransferase (SAT): SAT catalyzes the CoA-dependent acetylation of the side chain hydroxyl group of L-serine to form O-acetylserine, as the first step of a two-step biosynthetic pathway in bacteria and plants leading to the formation of...; Region: LbH_SAT; cd03354 114615012076 trimer interface [polypeptide binding]; other site 114615012077 active site 114615012078 substrate binding site [chemical binding]; other site 114615012079 CoA binding site [chemical binding]; other site 114615012080 nitrilotriacetate monoxygenase oxidizes nitrilotriacetate utilizing reduced flavin mononucleotide (FMNH2) and oxygen. The FMNH2 is provided by an NADH:flavin mononucleotide (FMN) oxidorductase that uses NADH to reduce FMN to FMNH2; Region: Nitrilotriacetate_monoxgenase; cd01095 114615012081 FMN-dependent oxidoreductase, nitrilotriacetate monooxygenase family; Region: FMN_nitrolo; TIGR03860 114615012082 active site 114615012083 non-prolyl cis peptide bond; other site 114615012084 ABC-type metal ion transport system, periplasmic component/surface antigen [Inorganic ion transport and metabolism]; Region: NlpA; COG1464 114615012085 NLPA lipoprotein; Region: Lipoprotein_9; pfam03180 114615012086 This family contains NADPH-dependent flavin reductase and oxygen-insensitive nitroreductase. These enzymes are homodimeric flavoproteins that contain one FMN per monomer as a cofactor. Flavin reductase catalyzes the reduction of flavin by using NADPH as...; Region: NfsA_FRP; cd02146 114615012087 dimer interface [polypeptide binding]; other site 114615012088 FMN binding site [chemical binding]; other site 114615012089 NADPH bind site [chemical binding]; other site 114615012090 dimethyl sulfone monooxygenase SfnG; Region: LLM_DMSO2_sfnG; TIGR04021 114615012091 Alkanesulfonate monoxygenase is the monoxygenase of a two-component system that catalyzes the conversion of alkanesulfonates to the corresponding aldehyde and sulfite. Alkanesulfonate monoxygenase (SsuD) has an absolute requirement for reduced flavin...; Region: Alkanesulfonate_monoxygenase; cd01094 114615012092 dimer interface [polypeptide binding]; other site 114615012093 active site 114615012094 non-prolyl cis peptide bond; other site 114615012095 insertion regions; other site 114615012096 Ferredoxin [Energy production and conversion]; Region: COG1146 114615012097 RPB11 and RPB3 subunits of RNA polymerase; Region: RNAP_RPB11_RPB3; cl11409 114615012098 Succinate dehydrogenase/fumarate reductase, flavoprotein subunit [Energy production and conversion]; Region: SdhA; COG1053 114615012099 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 114615012100 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4529 114615012101 FAD-NAD(P)-binding; Region: NAD_binding_9; pfam13454 114615012102 ABC-type metal ion transport system, periplasmic component/surface antigen [Inorganic ion transport and metabolism]; Region: NlpA; COG1464 114615012103 NLPA lipoprotein; Region: Lipoprotein_9; pfam03180 114615012104 hypothetical protein; Provisional; Region: PRK06208 114615012105 intersubunit interface [polypeptide binding]; other site 114615012106 active site 114615012107 Zn2+ binding site [ion binding]; other site 114615012108 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 114615012109 dimer interface [polypeptide binding]; other site 114615012110 conserved gate region; other site 114615012111 ABC-ATPase subunit interface; other site 114615012112 DL-methionine transporter ATP-binding subunit; Provisional; Region: metN; PRK11153 114615012113 ATP-binding cassette domain of methionine transporter; Region: ABC_MetN_methionine_transporter; cd03258 114615012114 Walker A/P-loop; other site 114615012115 ATP binding site [chemical binding]; other site 114615012116 Q-loop/lid; other site 114615012117 ABC transporter signature motif; other site 114615012118 Walker B; other site 114615012119 D-loop; other site 114615012120 H-loop/switch region; other site 114615012121 This domain is found at the C-terminus of ABC transporter proteins involved in D-methionine transport as well as a number of ferredoxin-like proteins; Region: NIL; smart00930 114615012122 Clavaminic acid synthetase (CAS) -like; CAS is a trifunctional Fe(II)/ 2-oxoglutarate (2OG) oxygenase carrying out three reactions in the biosynthesis of clavulanic acid, an inhibitor of class A serine beta-lactamases. In general, Fe(II)-2OG oxygenases...; Region: CAS_like; cl00184 114615012123 Probable taurine catabolism dioxygenase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: TauD; COG2175 114615012124 Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340 114615012125 Predicted acyltransferases [Lipid metabolism]; Region: COG1835 114615012126 Protein required for attachment to host cells; Region: Host_attach; pfam10116 114615012127 Protein of unknown function (DUF3775); Region: DUF3775; pfam12616 114615012128 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 114615012129 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 114615012130 active site 114615012131 metal binding site [ion binding]; metal-binding site 114615012132 Four helix bundle sensory module for signal transduction; Region: 4HB_MCP_1; pfam12729 114615012133 PAS domain S-box; Region: sensory_box; TIGR00229 114615012134 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 114615012135 putative active site [active] 114615012136 heme pocket [chemical binding]; other site 114615012137 PAS fold; Region: PAS_4; pfam08448 114615012138 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 114615012139 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 114615012140 ATP binding site [chemical binding]; other site 114615012141 Mg2+ binding site [ion binding]; other site 114615012142 G-X-G motif; other site 114615012143 Dihydrodipicolinate synthase family; Region: DHDPS-like; cd00408 114615012144 inhibitor site; inhibition site 114615012145 active site 114615012146 dimer interface [polypeptide binding]; other site 114615012147 catalytic residue [active] 114615012148 short chain dehydrogenase; Provisional; Region: PRK07791 114615012149 (3R)-hydroxyacyl-CoA dehydrogenase-like, classical(c)-like SDRs; Region: hydroxyacyl-CoA-like_DH_SDR_c-like; cd05353 114615012150 homodimer interface [polypeptide binding]; other site 114615012151 NAD binding site [chemical binding]; other site 114615012152 active site 114615012153 enoyl-CoA hydratase; Region: PLN02864 114615012154 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 114615012155 HDE_HSD The R-hydratase-like hot dog fold of the 17-beta-hydroxysteriod dehydrogenase (HSD), and Hydratase-Dehydrogenase-Epimerase (HDE) proteins. Other enzymes with this fold include MaoC dehydratase, and the fatty acid synthase beta subunit; Region: HDE_HSD; cd03448 114615012156 dimer interaction site [polypeptide binding]; other site 114615012157 substrate-binding tunnel; other site 114615012158 active site 114615012159 catalytic site [active] 114615012160 substrate binding site [chemical binding]; other site 114615012161 Rubredoxin-like zinc ribbon domain (DUF35_N); Region: DUF35_N; pfam12172 114615012162 DUF35 OB-fold domain; Region: DUF35; pfam01796 114615012163 acetyl-CoA acetyltransferase; Provisional; Region: PRK08142 114615012164 Thiolase domain associated with sterol carrier protein (SCP)-x isoform and related proteins; SCP-2 has multiple roles in intracellular lipid circulation and metabolism. The N-terminal presequence in the SCP-x isoform represents a peroxisomal...; Region: SCP-x_thiolase; cd00829 114615012165 active site 114615012166 Microtubule-binding protein MIP-T3; Region: MIP-T3; pfam10243 114615012167 Domain of unknown function (DUF4262); Region: DUF4262; pfam14081 114615012168 indolepyruvate ferredoxin oxidoreductase; Validated; Region: PRK09193 114615012169 Pyrimidine (PYR) binding domain of pyruvate ferredoxin oxidoreductase (PFOR), indolepyruvate ferredoxin oxidoreductase alpha subunit (IOR-alpha), and related proteins; Region: TPP_PYR_PFOR_IOR-alpha_like; cd07034 114615012170 dimer interface [polypeptide binding]; other site 114615012171 PYR/PP interface [polypeptide binding]; other site 114615012172 TPP binding site [chemical binding]; other site 114615012173 substrate binding site [chemical binding]; other site 114615012174 Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cl01629 114615012175 TPP-binding site [chemical binding]; other site 114615012176 Pyruvate:ferredoxin oxidoreductase and related 2-oxoacid:ferredoxin oxidoreductases, gamma subunit [Energy production and conversion]; Region: PorG; COG1014 114615012177 Predicted membrane protein [Function unknown]; Region: COG2860 114615012178 UPF0126 domain; Region: UPF0126; pfam03458 114615012179 UPF0126 domain; Region: UPF0126; pfam03458 114615012180 Photosystem P840 reaction-centre cytochrome c-551; Region: Cytochrome-c551; pfam10643 114615012181 Phosphoenolpyruvate phosphomutase; Region: PEP_mutase; pfam13714 114615012182 Members of the ICL/PEPM enzyme family catalyze either P-C or C-C bond formation/cleavage. Known members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate hydrolase (OAH), isocitrate...; Region: ICL_PEPM; cd00377 114615012183 tetramer interface [polypeptide binding]; other site 114615012184 active site 114615012185 Mg2+/Mn2+ binding site [ion binding]; other site 114615012186 NIPSNAP; Region: NIPSNAP; pfam07978 114615012187 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 114615012188 dimerization interface [polypeptide binding]; other site 114615012189 putative DNA binding site [nucleotide binding]; other site 114615012190 putative Zn2+ binding site [ion binding]; other site 114615012191 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 114615012192 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 114615012193 homoserine O-acetyltransferase; Provisional; Region: metX; cl17114 114615012194 EthD domain; Region: EthD; cl17553 114615012195 Acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta) [Lipid metabolism]; Region: COG4799 114615012196 malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682 114615012197 Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; cl17345 114615012198 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 114615012199 RNA polymerase sigma-70 factor, TIGR02960 family; Region: SigX5 114615012200 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 114615012201 DNA binding residues [nucleotide binding] 114615012202 SnoaL-like domain; Region: SnoaL_2; pfam12680 114615012203 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: FabG; COG1028 114615012204 classical (c) SDRs; Region: SDR_c; cd05233 114615012205 NAD(P) binding site [chemical binding]; other site 114615012206 peptidase T-like protein; Region: PepT-like; TIGR01883 114615012207 Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876 114615012208 metal binding site [ion binding]; metal-binding site 114615012209 Fucose dissimilation pathway protein FucU [Carbohydrate transport and metabolism]; Region: FucU; COG4154 114615012210 Domain of unknown function (DUF2383); Region: DUF2383; pfam09537 114615012211 Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285 114615012212 nucleoside/Zn binding site; other site 114615012213 dimer interface [polypeptide binding]; other site 114615012214 catalytic motif [active] 114615012215 Domain of unknown function (DUF4174); Region: DUF4174; pfam13778 114615012216 GAF domain; Region: GAF; pfam01590 114615012217 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 114615012218 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 114615012219 Walker A motif; other site 114615012220 ATP binding site [chemical binding]; other site 114615012221 Walker B motif; other site 114615012222 arginine finger; other site 114615012223 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cd00569 114615012224 DNA-binding interface [nucleotide binding]; DNA binding site 114615012225 chaperonin GroEL; Reviewed; Region: groEL; PRK12849 114615012226 GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344 114615012227 ring oligomerisation interface [polypeptide binding]; other site 114615012228 ATP/Mg binding site [chemical binding]; other site 114615012229 stacking interactions; other site 114615012230 hinge regions; other site 114615012231 Domain of unknown function DUF59; Region: DUF59; cl00941 114615012232 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cd01292 114615012233 active site 114615012234 MmoB/DmpM family; Region: MmoB_DmpM; pfam02406 114615012235 Aromatic and Alkene Monooxygenase Hydroxylase, subunit B, ferritin-like diiron-binding domain; Region: AAMH_B; cd01058 114615012236 dimerization interface [polypeptide binding]; other site 114615012237 CDP-6-deoxy-delta-3,4-glucoseen reductase; Validated; Region: PRK07609 114615012238 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 114615012239 catalytic loop [active] 114615012240 iron binding site [ion binding]; other site 114615012241 The oxygenase reductase FAD/NADH binding domain acts as part of the multi-component bacterial oxygenases which oxidize hydrocarbons. These flavoprotein monooxygenases use molecular oxygen as a substrate and require reduced FAD. One atom of oxygen is...; Region: monooxygenase_like; cd06212 114615012242 FAD binding pocket [chemical binding]; other site 114615012243 FAD binding motif [chemical binding]; other site 114615012244 phosphate binding motif [ion binding]; other site 114615012245 beta-alpha-beta structure motif; other site 114615012246 NAD binding pocket [chemical binding]; other site 114615012247 Aromatic and Alkene Monooxygenase Hydroxylase, subunit A, ferritin-like diiron-binding domain; Region: AAMH_A; cd01057 114615012248 dimerization interface [polypeptide binding]; other site 114615012249 putative path to active site cavity [active] 114615012250 diiron center [ion binding]; other site 114615012251 emp24/gp25L/p24 family/GOLD; Region: EMP24_GP25L; pfam01105 114615012252 Zn-dependent alcohol dehydrogenases [General function prediction only]; Region: AdhP; COG1064 114615012253 D-arabinose dehydrogenase; Region: arabinose_DH_like; cd05284 114615012254 NAD binding site [chemical binding]; other site 114615012255 substrate binding site [chemical binding]; other site 114615012256 catalytic Zn binding site [ion binding]; other site 114615012257 structural Zn binding site [ion binding]; other site 114615012258 Transcriptional activator of acetoin/glycerol metabolism [Secondary metabolites biosynthesis, transport, and catabolism / Transcription]; Region: AcoR; COG3284 114615012259 PAS domain; Region: PAS; smart00091 114615012260 putative active site [active] 114615012261 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 114615012262 Walker A motif; other site 114615012263 ATP binding site [chemical binding]; other site 114615012264 Walker B motif; other site 114615012265 arginine finger; other site 114615012266 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 114615012267 SseB protein; Region: SseB; cl06279 114615012268 urea carboxylase-associated protein 1; Region: urea_degr_1; TIGR03424 114615012269 Domain of unknown function (DUF1989); Region: DUF1989; pfam09347 114615012270 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 114615012271 substrate binding pocket [chemical binding]; other site 114615012272 membrane-bound complex binding site; other site 114615012273 hinge residues; other site 114615012274 Alkanesulfonate monoxygenase is the monoxygenase of a two-component system that catalyzes the conversion of alkanesulfonates to the corresponding aldehyde and sulfite. Alkanesulfonate monoxygenase (SsuD) has an absolute requirement for reduced flavin...; Region: Alkanesulfonate_monoxygenase; cd01094 114615012275 active site 114615012276 alkanesulfonate monooxygenase, FMNH(2)-dependent; Region: alk_sulf_monoox; TIGR03565 114615012277 dimer interface [polypeptide binding]; other site 114615012278 non-prolyl cis peptide bond; other site 114615012279 insertion regions; other site 114615012280 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 114615012281 Acyl-CoA dehydrogenase, N-terminal domain; Region: Acyl-CoA_dh_N; pfam02771 114615012282 Acyl-CoA dehydrogenase; Region: ACAD; cd00567 114615012283 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 114615012284 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 114615012285 Walker A/P-loop; other site 114615012286 ATP binding site [chemical binding]; other site 114615012287 Q-loop/lid; other site 114615012288 ABC transporter signature motif; other site 114615012289 Walker B; other site 114615012290 D-loop; other site 114615012291 H-loop/switch region; other site 114615012292 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 114615012293 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 114615012294 dimer interface [polypeptide binding]; other site 114615012295 conserved gate region; other site 114615012296 putative PBP binding loops; other site 114615012297 ABC-ATPase subunit interface; other site 114615012298 NMT1/THI5 like; Region: NMT1; pfam09084 114615012299 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 114615012300 substrate binding pocket [chemical binding]; other site 114615012301 membrane-bound complex binding site; other site 114615012302 Low-density lipoprotein-receptor YWTD domain; Region: LY; smart00135 114615012303 ATP-grasp ribosomal peptide maturase, SAV_5884 family; Region: GRASP_SAV_5884; TIGR04187 114615012304 ATP-grasp domain; Region: ATP-grasp_4; cl17255 114615012305 Bacterial Ig-like domain (group 2); Region: Big_2; pfam02368 114615012306 Uncharacterized protein conserved in bacteria (DUF2313); Region: DUF2313; cl01542 114615012307 conserved hypothetical protein, phage tail-like region; Region: TIGR02243 114615012308 conserved hypothetical protein, phage tail-like region; Region: TIGR02243 114615012309 conserved hypothetical protein, phage tail-like region; Region: TIGR02243 114615012310 conserved hypothetical protein, phage tail-like region; Region: TIGR02243 114615012311 Gene 25-like lysozyme; Region: GPW_gp25; pfam04965 114615012312 Phage-related baseplate assembly protein; Region: Phage_base_V; pfam04717 114615012313 Domain of unknown function (DUF4157); Region: DUF4157; pfam13699 114615012314 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 114615012315 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 114615012316 Walker A motif; other site 114615012317 ATP binding site [chemical binding]; other site 114615012318 Walker B motif; other site 114615012319 arginine finger; other site 114615012320 Protein of unknown function (DUF4255); Region: DUF4255; pfam14065 114615012321 DNA polymerase III subunits gamma and tau; Provisional; Region: PRK12323 114615012322 T4-like virus tail tube protein gp19; Region: Phage_T4_gp19; pfam06841 114615012323 Phage tail sheath protein; Region: Phage_sheath_1; cl01389 114615012324 Phage tail sheath protein FI [General function prediction only]; Region: COG3497 114615012325 Alpha-glucosidases, family 31 of glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: COG1501 114615012326 Galactose mutarotase-like; Region: Gal_mutarotas_2; pfam13802 114615012327 Glycosyl hydrolase family 31 (GH31) domain of a bacterial protein family represented by Escherichia coli protein Aec37. The gene encoding Aec37 (aec-37) is located within a genomic island (AGI-3) isolated from the extraintestinal avian pathogenic...; Region: GH31_glycosidase_Aec37; cd06599 114615012328 putative active site [active] 114615012329 putative catalytic site [active] 114615012330 glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650 114615012331 The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301 114615012332 Walker A/P-loop; other site 114615012333 ATP binding site [chemical binding]; other site 114615012334 Q-loop/lid; other site 114615012335 ABC transporter signature motif; other site 114615012336 Walker B; other site 114615012337 D-loop; other site 114615012338 H-loop/switch region; other site 114615012339 TOBE domain; Region: TOBE_2; pfam08402 114615012340 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 114615012341 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 114615012342 dimer interface [polypeptide binding]; other site 114615012343 conserved gate region; other site 114615012344 putative PBP binding loops; other site 114615012345 ABC-ATPase subunit interface; other site 114615012346 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 114615012347 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 114615012348 dimer interface [polypeptide binding]; other site 114615012349 conserved gate region; other site 114615012350 putative PBP binding loops; other site 114615012351 ABC-ATPase subunit interface; other site 114615012352 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 114615012353 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 114615012354 catabolite control protein A; Region: ccpA; TIGR01481 114615012355 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 114615012356 DNA binding site [nucleotide binding] 114615012357 domain linker motif; other site 114615012358 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 114615012359 dimerization interface [polypeptide binding]; other site 114615012360 ligand binding site [chemical binding]; other site 114615012361 This model contains proteins with the VRR-NUC domain; Region: VRR_NUC; smart00990 114615012362 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 114615012363 active site 114615012364 catalytic site [active] 114615012365 substrate binding site [chemical binding]; other site 114615012366 amidase; Provisional; Region: PRK08310 114615012367 indole-3-acetamide amidohydrolase; Region: PLN02722 114615012368 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 114615012369 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_7; cd08512 114615012370 Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154 114615012371 Amidase; Region: Amidase; pfam01425 114615012372 ABC-type oligopeptide transport system, ATPase component [Amino acid transport and metabolism]; Region: AppF; COG4608 114615012373 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 114615012374 Walker A/P-loop; other site 114615012375 ATP binding site [chemical binding]; other site 114615012376 Q-loop/lid; other site 114615012377 ABC transporter signature motif; other site 114615012378 Walker B; other site 114615012379 D-loop; other site 114615012380 H-loop/switch region; other site 114615012381 oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727 114615012382 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 114615012383 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 114615012384 Walker A/P-loop; other site 114615012385 ATP binding site [chemical binding]; other site 114615012386 Q-loop/lid; other site 114615012387 ABC transporter signature motif; other site 114615012388 Walker B; other site 114615012389 D-loop; other site 114615012390 H-loop/switch region; other site 114615012391 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 114615012392 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 114615012393 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 114615012394 dimer interface [polypeptide binding]; other site 114615012395 conserved gate region; other site 114615012396 putative PBP binding loops; other site 114615012397 ABC-ATPase subunit interface; other site 114615012398 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 114615012399 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 114615012400 dimer interface [polypeptide binding]; other site 114615012401 conserved gate region; other site 114615012402 putative PBP binding loops; other site 114615012403 ABC-ATPase subunit interface; other site 114615012404 DNA-binding transcriptional repressor PuuR; Provisional; Region: PRK09943 114615012405 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 114615012406 non-specific DNA binding site [nucleotide binding]; other site 114615012407 salt bridge; other site 114615012408 sequence-specific DNA binding site [nucleotide binding]; other site 114615012409 Cupin domain; Region: Cupin_2; pfam07883 114615012410 Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154 114615012411 Amidase; Region: Amidase; cl11426 114615012412 Putative intracellular protease/amidase [General function prediction only]; Region: ThiJ; COG0693 114615012413 Type 1 glutamine amidotransferase (GATase1)-like domain found in proteins similar to Escherichia coli Hsp31 protein; Region: GATase1_Hsp31_like; cd03141 114615012414 potential catalytic triad [active] 114615012415 conserved cys residue [active] 114615012416 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 114615012417 homoserine O-acetyltransferase; Provisional; Region: metX; cl17114 114615012418 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 114615012419 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 114615012420 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 114615012421 The (Largely Gram-negative Bacterial) Hydrophobe/Amphiphile Efflux-1 (HAE1) Family; Region: 2A0602; TIGR00915 114615012422 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 114615012423 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 114615012424 HlyD family secretion protein; Region: HlyD_3; pfam13437 114615012425 Helix-Turn-Helix DNA binding domain of putative MlrA-like transcription regulators; Region: HTH_MlrA-like_sg2; cd04765 114615012426 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 114615012427 DNA binding residues [nucleotide binding] 114615012428 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 114615012429 IHF dimer interface [polypeptide binding]; other site 114615012430 IHF - DNA interface [nucleotide binding]; other site 114615012431 3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK09352 114615012432 Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830 114615012433 dimer interface [polypeptide binding]; other site 114615012434 active site 114615012435 CoA binding pocket [chemical binding]; other site 114615012436 putative phosphate acyltransferase; Provisional; Region: PRK05331 114615012437 Uncharacterized ACR, COG1399; Region: DUF177; pfam02620 114615012438 Ubiquinol-cytochrome C chaperone; Region: Ubiq_cyt_C_chap; cl12045 114615012439 Outer membrane lipoprotein OmlA (small protein A) [Cell envelope biogenesis, outer membrane]; Region: OlmA; COG2913 114615012440 SmpA / OmlA family; Region: SmpA_OmlA; pfam04355 114615012441 Uncharacterized protein conserved in bacteria (DUF2336); Region: DUF2336; pfam10098 114615012442 H(+) -translocating inorganic pyrophosphatase; Region: PLN02255; cl11452 114615012443 membrane-bound proton-translocating pyrophosphatase; Validated; Region: hppA; PRK00733 114615012444 thiamine monophosphate kinase; Provisional; Region: PRK05731 114615012445 ThiL (Thiamine-monophosphate kinase) plays a dual role in de novo biosynthesis and in salvage of exogenous thiamine. Thiamine salvage occurs in two steps, with thiamine kinase catalyzing the formation of thiamine phosphate, and ThiL catalyzing the...; Region: ThiL; cd02194 114615012446 ATP binding site [chemical binding]; other site 114615012447 dimerization interface [polypeptide binding]; other site 114615012448 transcription antitermination protein NusB; Reviewed; Region: nusB; PRK00202 114615012449 putative RNA binding site [nucleotide binding]; other site 114615012450 lumazine synthase (6,7-dimethyl-8-ribityllumazine synthase, LS), catalyzes the penultimate step in the biosynthesis of riboflavin (vitamin B2); type-I; Region: Lumazine_synthase-I; cd09209 114615012451 homopentamer interface [polypeptide binding]; other site 114615012452 active site 114615012453 riboflavin synthase subunit alpha; Provisional; Region: PRK09289 114615012454 Lumazine binding domain; Region: Lum_binding; pfam00677 114615012455 Lumazine binding domain; Region: Lum_binding; pfam00677 114615012456 riboflavin biosynthesis protein RibD; Region: eubact_ribD; TIGR00326 114615012457 Riboflavin-specific deaminase. Riboflavin biosynthesis protein RibD (Diaminohydroxyphosphoribosylaminopyrimidine deaminase) catalyzes the deamination of 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate, which is an intermediate step in the...; Region: Riboflavin_deaminase-reductase; cd01284 114615012458 catalytic motif [active] 114615012459 Zn binding site [ion binding]; other site 114615012460 RibD C-terminal domain; Region: RibD_C; cl17279 114615012461 transcriptional regulator NrdR; Validated; Region: nrdR; PRK00464 114615012462 ATP cone domain; Region: ATP-cone; pfam03477 114615012463 serine hydroxymethyltransferase; Reviewed; Region: glyA; PRK00011 114615012464 Serine-glycine hydroxymethyltransferase (SHMT). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). SHMT carries out interconversion of serine and glycine; it catalyzes the transfer of hydroxymethyl...; Region: SHMT; cd00378 114615012465 dimer interface [polypeptide binding]; other site 114615012466 active site 114615012467 glycine-pyridoxal phosphate binding site [chemical binding]; other site 114615012468 folate binding site [chemical binding]; other site 114615012469 Transcriptional regulators [Transcription]; Region: MarR; COG1846 114615012470 MarR family; Region: MarR_2; cl17246 114615012471 Porphobilinogen synthase (PBGS), which is also called delta-aminolevulinic acid dehydratase (ALAD), catalyzes the condensation of two 5-aminolevulinic acid (ALA) molecules to form the pyrrole porphobilinogen (PBG), which is the second step in the...; Region: ALAD_PBGS_aspartate_rich; cd04823 114615012472 dimer interface [polypeptide binding]; other site 114615012473 allosteric magnesium binding site [ion binding]; other site 114615012474 active site 114615012475 aspartate-rich active site metal binding site; other site 114615012476 Schiff base residues; other site 114615012477 RDD family; Region: RDD; pfam06271 114615012478 arginyl-tRNA-protein transferase; Provisional; Region: PRK01305 114615012479 Arginine-tRNA-protein transferase, N terminus; Region: ATE_N; pfam04376 114615012480 Arginine-tRNA-protein transferase, C terminus; Region: ATE_C; pfam04377 114615012481 manganese transport protein MntH; Reviewed; Region: PRK00701 114615012482 Natural resistance-associated macrophage protein; Region: Nramp; pfam01566 114615012483 Methyltransferase domain; Region: Methyltransf_23; pfam13489 114615012484 Methyltransferase domain; Region: Methyltransf_12; pfam08242 114615012485 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 114615012486 putative substrate translocation pore; other site 114615012487 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 114615012488 Ligand Binding Site [chemical binding]; other site 114615012489 Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114 114615012490 cyclase homology domain; Region: CHD; cd07302 114615012491 nucleotidyl binding site; other site 114615012492 metal binding site [ion binding]; metal-binding site 114615012493 dimer interface [polypeptide binding]; other site 114615012494 Arsenate Reductase (ArsC) family, ArsC subfamily; arsenic reductases similar to that encoded by arsC on the R733 plasmid of Escherichia coli. E. coli ArsC catalyzes the reduction of arsenate [As(V)] to arsenite [As(III)], the first step in the...; Region: ArsC_ArsC; cd03034 114615012495 ArsC family; Region: ArsC; pfam03960 114615012496 catalytic residues [active] 114615012497 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cl00125 114615012498 active site residue [active] 114615012499 Chromate resistance exported protein; Region: Chrome_Resist; pfam09828 114615012500 Chromate transport protein ChrA [Inorganic ion transport and metabolism]; Region: ChrA; COG2059 114615012501 Chromate transporter; Region: Chromate_transp; pfam02417 114615012502 Co/Zn/Cd efflux system component [Inorganic ion transport and metabolism]; Region: CzcD; COG1230 114615012503 DNA topoisomerase IV subunit A; Validated; Region: PRK05561 114615012504 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187 114615012505 CAP-like domain; other site 114615012506 active site 114615012507 primary dimer interface [polypeptide binding]; other site 114615012508 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 114615012509 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 114615012510 BAAT / Acyl-CoA thioester hydrolase C terminal; Region: BAAT_C; pfam08840 114615012511 Glutathione S-transferase (GST) family, N-terminal domain; a large, diverse group of cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of endogenous and xenobiotic...; Region: GST_N_family; cd00570 114615012512 C-terminal domain interface [polypeptide binding]; other site 114615012513 GSH binding site (G-site) [chemical binding]; other site 114615012514 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 114615012515 dimer interface [polypeptide binding]; other site 114615012516 C-terminal, alpha helical domain of the Glutathione S-transferase family; Region: GST_C_family; cl02776 114615012517 dimer interface [polypeptide binding]; other site 114615012518 substrate binding pocket (H-site) [chemical binding]; other site 114615012519 putative FAD-binding dehydrogenase; Reviewed; Region: PRK12834 114615012520 3-ketosteroid-delta-1-dehydrogenase; Reviewed; Region: PRK12844 114615012521 hypothetical protein; Validated; Region: PRK07586 114615012522 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 114615012523 PYR/PP interface [polypeptide binding]; other site 114615012524 dimer interface [polypeptide binding]; other site 114615012525 TPP binding site [chemical binding]; other site 114615012526 Thiamine pyrophosphate (TPP) family, BFDC subfamily, TPP-binding module; composed of proteins similar to Pseudomonas putida benzoylformate decarboxylase (BFDC). P. putida BFDC plays a role in the mandelate pathway, catalyzing the conversion of...; Region: TPP_BFDC; cd02002 114615012527 TPP-binding site [chemical binding]; other site 114615012528 dimer interface [polypeptide binding]; other site 114615012529 Transcriptional regulator [Transcription]; Region: LysR; COG0583 114615012530 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 114615012531 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 114615012532 dimerization interface [polypeptide binding]; other site 114615012533 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3602 114615012534 ACT domain; Region: ACT_3; pfam10000 114615012535 Family description; Region: ACT_7; pfam13840 114615012536 Predicted glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: ECM4; COG0435 114615012537 Glutathione S-transferase, N-terminal domain; Region: GST_N_2; pfam13409 114615012538 C-terminal, alpha helical domain of Class Omega-like Glutathione S-transferases; Region: GST_C_Omega_like; cd03190 114615012539 putative dimer interface [polypeptide binding]; other site 114615012540 N-terminal domain interface [polypeptide binding]; other site 114615012541 putative substrate binding pocket (H-site) [chemical binding]; other site 114615012542 DNA repair protein RecO; Reviewed; Region: recO; PRK00085 114615012543 Recombination protein O N terminal; Region: RecO_N; pfam11967 114615012544 Recombination protein O C terminal; Region: RecO_C; pfam02565 114615012545 GTPase Era; Reviewed; Region: era; PRK00089 114615012546 E. coli Ras-like protein (Era) is a multifunctional GTPase; Region: Era; cd04163 114615012547 G1 box; other site 114615012548 GTP/Mg2+ binding site [chemical binding]; other site 114615012549 Switch I region; other site 114615012550 G2 box; other site 114615012551 Switch II region; other site 114615012552 G3 box; other site 114615012553 G4 box; other site 114615012554 G5 box; other site 114615012555 KH domain; Region: KH_2; pfam07650 114615012556 ribonuclease III, bacterial; Region: RNaseIII; TIGR02191 114615012557 RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in...; Region: RIBOc; cd00593 114615012558 dimerization interface [polypeptide binding]; other site 114615012559 active site 114615012560 metal binding site [ion binding]; metal-binding site 114615012561 Double-stranded RNA binding motif. Binding is not sequence specific but is highly specific for double stranded RNA. Found in a variety of proteins including dsRNA dependent protein kinase PKR, RNA helicases, Drosophila staufen protein, E. coli RNase III; Region: DSRM; cd00048 114615012562 dsRNA binding site [nucleotide binding]; other site 114615012563 signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227 114615012564 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 114615012565 Catalytic site [active] 114615012566 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 114615012567 4'-phosphopantetheinyl transferase; Provisional; Region: acpS; PRK00070 114615012568 Pyridoxine 5'-phosphate (PNP) synthase domain; pyridoxal 5'-phosphate is the active form of vitamin B6 that acts as an essential, ubiquitous coenzyme in amino acid metabolism. In bacteria, formation of pyridoxine 5'-phosphate is a step in...; Region: PNPsynthase; cd00003 114615012569 active site 114615012570 hydrophilic channel; other site 114615012571 dimerization interface [polypeptide binding]; other site 114615012572 catalytic residues [active] 114615012573 active site lid [active] 114615012574 Guanosine polyphosphate pyrophosphohydrolases/synthetases [Signal transduction mechanisms / Transcription]; Region: SpoT; COG0317 114615012575 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 114615012576 Zn2+ binding site [ion binding]; other site 114615012577 Mg2+ binding site [ion binding]; other site 114615012578 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 114615012579 synthetase active site [active] 114615012580 NTP binding site [chemical binding]; other site 114615012581 metal binding site [ion binding]; metal-binding site 114615012582 TGS_RelA_SpoT: The RelA (SpoT) protein, also referred to as ppGpp hydrolase/synthetase, is a ribosome-associated protein that is activated during amino acid starvation and thought to mediate the stringent response. RelA contains a TGS domain, named after...; Region: TGS_RelA_SpoT; cd01668 114615012583 ACT domain found C-terminal of the RelA/SpoT domains; Region: ACT_RelA-SpoT; cd04876 114615012584 DNA-directed RNA polymerase subunit omega; Reviewed; Region: rpoZ; PRK00392 114615012585 LabA_like proteins; Region: LabA; cd10911 114615012586 Uncharacterized conserved protein [Function unknown]; Region: COG1432 114615012587 putative metal binding site [ion binding]; other site 114615012588 Family-5 Uracil-DNA glycosylases (UDG), found in thermophilic organisms; Region: UDG_F5_TTUDGB_like; cd10031 114615012589 Fe-S cluster binding site [ion binding]; other site 114615012590 DNA binding site [nucleotide binding] 114615012591 active site 114615012592 Peroxiredoxin (PRX) family, Bacterioferritin comigratory protein (BCP) subfamily; composed of thioredoxin-dependent thiol peroxidases, widely expressed in pathogenic bacteria, that protect cells against toxicity from reactive oxygen species by reducing...; Region: PRX_BCP; cd03017 114615012593 catalytic triad [active] 114615012594 Small protein B (SmpB) is a component of the trans-translation system in prokaryotes for releasing stalled ribosome from damaged messenger RNAs; Region: SmpB; cd09294 114615012595 SmpB-tmRNA interface; other site 114615012596 large-conductance mechanosensitive channel; Provisional; Region: mscL; PRK13952 114615012597 large-conductance mechanosensitive channel; Reviewed; Region: mscL; PRK00567 114615012598 Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329 114615012599 Dihydrodipicolinate synthase (DHDPS); Region: DHDPS; cd00950 114615012600 dimer interface [polypeptide binding]; other site 114615012601 active site 114615012602 catalytic residue [active] 114615012603 Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741 114615012604 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 114615012605 N-acetyl-D-glucosamine binding site [chemical binding]; other site 114615012606 catalytic residue [active] 114615012607 Porin subfamily; Region: Porin_2; pfam02530 114615012608 Porin subfamily; Region: Porin_2; pfam02530 114615012609 aspartyl/glutamyl-tRNA amidotransferase subunit B; Validated; Region: gatB; PRK05477 114615012610 GatB/GatE catalytic domain; Region: GatB_N; pfam02934 114615012611 GatB domain; Region: GatB_Yqey; smart00845 114615012612 Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154 114615012613 aspartyl/glutamyl-tRNA amidotransferase subunit A; Reviewed; Region: gatA; PRK00012 114615012614 aspartyl/glutamyl-tRNA amidotransferase subunit C; Reviewed; Region: gatC; PRK00034 114615012615 Dioxygenases related to 2-nitropropane dioxygenase [General function prediction only]; Region: COG2070 114615012616 2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730 114615012617 FMN binding site [chemical binding]; other site 114615012618 substrate binding site [chemical binding]; other site 114615012619 putative catalytic residue [active] 114615012620 Nitronate monooxygenase; Region: NMO; pfam03060 114615012621 2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730 114615012622 FMN binding site [chemical binding]; other site 114615012623 substrate binding site [chemical binding]; other site 114615012624 putative catalytic residue [active] 114615012625 Transcriptional regulator [Transcription]; Region: LysR; COG0583 114615012626 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 114615012627 The C-terminal substrate binding domain of LysR-type transcriptional regulators, YofA and SoxR, contains the type 2 periplasmic binding fold; Region: PBP2_YofA_SoxR_like; cd08442 114615012628 putative dimerization interface [polypeptide binding]; other site 114615012629 Putative cyclase; Region: Cyclase; pfam04199 114615012630 heme ABC exporter, ATP-binding protein CcmA; Region: ccmA; TIGR01189 114615012631 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 114615012632 Walker A/P-loop; other site 114615012633 ATP binding site [chemical binding]; other site 114615012634 Q-loop/lid; other site 114615012635 ABC transporter signature motif; other site 114615012636 Walker B; other site 114615012637 D-loop; other site 114615012638 H-loop/switch region; other site 114615012639 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 114615012640 ABC transporter; Region: ABC_tran; pfam00005 114615012641 Holliday junction resolvase-like protein; Reviewed; Region: PRK00109 114615012642 Predicted permeases [General function prediction only]; Region: COG0679 114615012643 CAAX protease self-immunity; Region: Abi; pfam02517 114615012644 CAAX protease self-immunity; Region: Abi; pfam02517 114615012645 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 114615012646 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 114615012647 active site 114615012648 aspartate carbamoyltransferase catalytic subunit; Provisional; Region: pyrB; PRK00856 114615012649 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 114615012650 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 114615012651 dihydroorotase; Validated; Region: PRK09059 114615012652 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 114615012653 Dihydroorotase (DHOase), subgroup IIa; DHOases catalyze the reversible interconversion of carbamoyl aspartate to dihydroorotate, a key reaction in pyrimidine biosynthesis. This subgroup also contains proteins that lack the active site, like unc-33, a C; Region: DHOase_IIa; cd01317 114615012654 active site 114615012655 putative glycerol-3-phosphate acyltransferase PlsY; Provisional; Region: PRK00220 114615012656 Patatins and Phospholipases; Region: Patatin_and_cPLA2; cl11396 114615012657 active site 114615012658 nucleophile elbow; other site 114615012659 Predicted Rossmann fold nucleotide-binding protein involved in DNA uptake [DNA replication, recombination, and repair / Intracellular trafficking and secretion]; Region: Smf; COG0758 114615012660 DNA protecting protein DprA; Region: dprA; TIGR00732 114615012661 DNA topoisomerase I subunit omega; Validated; Region: PRK07561 114615012662 TOPRIM_TopoIA_TopoI: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to Escherichia coli DNA topoisomerase I. Type IA DNA topoisomerases remove (relax) negative supercoils in the...; Region: TOPRIM_TopoIA_TopoI; cd03363 114615012663 active site 114615012664 interdomain interaction site; other site 114615012665 putative metal-binding site [ion binding]; other site 114615012666 nucleotide binding site [chemical binding]; other site 114615012667 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186 114615012668 domain I; other site 114615012669 DNA binding groove [nucleotide binding] 114615012670 phosphate binding site [ion binding]; other site 114615012671 domain II; other site 114615012672 domain III; other site 114615012673 nucleotide binding site [chemical binding]; other site 114615012674 catalytic site [active] 114615012675 domain IV; other site 114615012676 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 114615012677 Topoisomerase C-terminal repeat; Region: Toprim_C_rpt; pfam13368 114615012678 Topoisomerase C-terminal repeat; Region: Toprim_C_rpt; pfam13368 114615012679 ribonuclease R; Region: RNase_R; TIGR02063 114615012680 RNB domain; Region: RNB; pfam00773 114615012681 S1_RNase_R: RNase R C-terminal S1 domain. RNase R is a processive 3' to 5' exoribonuclease, which is a homolog of RNase II. RNase R degrades RNA with secondary structure having a 3' overhang of at least 7 nucleotides. RNase R and PNPase...; Region: S1_RNase_R; cd04471 114615012682 RNA binding site [nucleotide binding]; other site 114615012683 hypothetical protein; Provisional; Region: PRK05978 114615012684 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cd02883 114615012685 nudix motif; other site 114615012686 nitrilotriacetate monoxygenase oxidizes nitrilotriacetate utilizing reduced flavin mononucleotide (FMNH2) and oxygen. The FMNH2 is provided by an NADH:flavin mononucleotide (FMN) oxidorductase that uses NADH to reduce FMN to FMNH2; Region: Nitrilotriacetate_monoxgenase; cd01095 114615012687 FMN-dependent oxidoreductase, nitrilotriacetate monooxygenase family; Region: FMN_nitrolo; TIGR03860 114615012688 active site 114615012689 non-prolyl cis peptide bond; other site 114615012690 50S ribosomal protein L33; Validated; Region: rpmG; PRK00595 114615012691 Globin domain present in Globin-Coupled-Sensors (GCS). These domains detect changes in intracellular concentrations of oxygen, carbon monoxyde, or nitrous oxide, which result in aerotaxis and/or gene regulation. One subgroup, the HemATs, are aerotactic...; Region: sensor_globin; cd01068 114615012692 heme-binding site [chemical binding]; other site 114615012693 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 114615012694 dimer interface [polypeptide binding]; other site 114615012695 Methyl-accepting chemotaxis protein (MCP) signalling domain; Region: MCPsignal; pfam00015 114615012696 putative CheW interface [polypeptide binding]; other site 114615012697 Cysteine rich repeat; Region: Cys_rich_FGFR; pfam00839 114615012698 Domain of unknown function (DUF1127); Region: DUF1127; pfam06568 114615012699 Domain of unknown function (DUF1127); Region: DUF1127; pfam06568 114615012700 DNA gyrase subunit B; Provisional; Region: gyrB; PRK14939 114615012701 response regulator PleD; Reviewed; Region: pleD; PRK09581 114615012702 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 114615012703 active site 114615012704 phosphorylation site [posttranslational modification] 114615012705 intermolecular recognition site; other site 114615012706 dimerization interface [polypeptide binding]; other site 114615012707 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 114615012708 active site 114615012709 phosphorylation site [posttranslational modification] 114615012710 intermolecular recognition site; other site 114615012711 dimerization interface [polypeptide binding]; other site 114615012712 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 114615012713 metal binding site [ion binding]; metal-binding site 114615012714 active site 114615012715 I-site; other site 114615012716 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 114615012717 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 114615012718 active site 114615012719 phosphorylation site [posttranslational modification] 114615012720 intermolecular recognition site; other site 114615012721 dimerization interface [polypeptide binding]; other site 114615012722 Protein of unknown function (DUF3572); Region: DUF3572; pfam12096 114615012723 DNA polymerase IV; Provisional; Region: PRK02794 114615012724 DNA Polymerase IV/Kappa; Region: PolY_Pol_IV_kappa; cd03586 114615012725 active site 114615012726 DNA binding site [nucleotide binding] 114615012727 Domain of unknown function (DUF1849); Region: DUF1849; pfam08904 114615012728 This group of proteins belong to a large family of YjgF/YER057c/UK114-like proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence...; Region: YjgF_YER057c_UK114_like_1; cd02199 114615012729 homotrimer interaction site [polypeptide binding]; other site 114615012730 putative active site [active] 114615012731 Catalytic domain of phosphoinositide-specific phospholipase C-like phosphodiesterases superfamily; Region: PI-PLCc_GDPD_SF; cl14615 114615012732 Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584 114615012733 active site 114615012734 catalytic site [active] 114615012735 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3146 114615012736 Protein of unknown function, DUF482; Region: DUF482; pfam04339 114615012737 HINT (histidine triad nucleotide-binding protein) subgroup: Members of this CD belong to the superfamily of histidine triad hydrolases that act on alpha-phosphate of ribonucleotides. This subgroup includes members from all three forms of cellular life; Region: HINT_subgroup; cd01277 114615012738 HIT family signature motif; other site 114615012739 catalytic residue [active] 114615012740 nicotinate-nucleotide pyrophosphorylase; Provisional; Region: PRK06106 114615012741 Quinolinate phosphoribosyl transferase (QAPRTase or QPRTase), also called nicotinate-nucleotide pyrophosphorylase, is involved in the de novo synthesis of NAD in both prokaryotes and eukaryotes. It catalyses the reaction of quinolinic acid (QA) with...; Region: QPRTase; cd01572 114615012742 dimerization interface [polypeptide binding]; other site 114615012743 active site 114615012744 L-aspartate oxidase; Provisional; Region: PRK07512 114615012745 L-aspartate oxidase; Provisional; Region: PRK06175 114615012746 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 114615012747 quinolinate synthetase; Provisional; Region: PRK09375 114615012748 Uncharacterized conserved protein [General function prediction only]; Region: COG4111 114615012749 Escherichia coli YaeB and related proteins; Region: UPF0066; cd09281 114615012750 homodimer interaction site [polypeptide binding]; other site 114615012751 cofactor binding site; other site 114615012752 AzlC protein; Region: AzlC; pfam03591 114615012753 Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741 114615012754 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 114615012755 N-acetyl-D-glucosamine binding site [chemical binding]; other site 114615012756 catalytic residue [active] 114615012757 Sporulation related domain; Region: SPOR; pfam05036 114615012758 glycine reductase, selenoprotein B; Region: gly_red_sel_B; TIGR01917 114615012759 PEGA domain; Region: PEGA; pfam08308 114615012760 Nitrilases, cyanide hydratase (CH)s, and similar proteins (class 1 nitrilases); Region: nitrilases_CHs; cd07564 114615012761 Predicted amidohydrolase [General function prediction only]; Region: COG0388 114615012762 putative active site [active] 114615012763 catalytic triad [active] 114615012764 putative dimer interface [polypeptide binding]; other site 114615012765 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 114615012766 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 114615012767 Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010 114615012768 Cytochrome c; Region: Cytochrom_C; pfam00034 114615012769 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 114615012770 Major Facilitator Superfamily; Region: MFS_1; pfam07690 114615012771 putative substrate translocation pore; other site 114615012772 hypothetical protein; Provisional; Region: PRK10621 114615012773 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 114615012774 ATP-dependent Clp protease ATP-binding subunit clpA; Region: ClpA; TIGR02639 114615012775 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 114615012776 Walker A motif; other site 114615012777 ATP binding site [chemical binding]; other site 114615012778 Walker B motif; other site 114615012779 arginine finger; other site 114615012780 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 114615012781 Walker A motif; other site 114615012782 ATP binding site [chemical binding]; other site 114615012783 Walker B motif; other site 114615012784 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 114615012785 Uncharacterized conserved protein [Function unknown]; Region: COG2127 114615012786 Phasin protein; Region: Phasin_2; pfam09361 114615012787 D-alanyl-D-alanine carboxypeptidase [Cell envelope biogenesis, outer membrane]; Region: DacC; COG1686 114615012788 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872 114615012789 Sporulation related domain; Region: SPOR; pfam05036 114615012790 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 114615012791 HSP70 interaction site [polypeptide binding]; other site 114615012792 von Willebrand factor type A domain; Region: VWA_2; pfam13519 114615012793 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 114615012794 ATPase MipZ; Region: MipZ; pfam09140 114615012795 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 114615012796 P-loop; other site 114615012797 Magnesium ion binding site [ion binding]; other site 114615012798 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 114615012799 Magnesium ion binding site [ion binding]; other site 114615012800 Pantoate-beta-alanine ligase; Region: PanC; cd00560 114615012801 pantoate--beta-alanine ligase; Region: panC; TIGR00018 114615012802 active site 114615012803 ATP-binding site [chemical binding]; other site 114615012804 pantoate-binding site; other site 114615012805 HXXH motif; other site 114615012806 Protein of unknown function (DUF1489); Region: DUF1489; pfam07370 114615012807 Bacterial protein of unknown function (DUF937); Region: DUF937; cl01528 114615012808 GST_N family, unknown subfamily 1; composed of uncharacterized proteins, predominantly from bacteria, with similarity to GSTs. GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with...; Region: GST_N_1; cd03043 114615012809 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 114615012810 putative C-terminal domain interface [polypeptide binding]; other site 114615012811 putative GSH binding site (G-site) [chemical binding]; other site 114615012812 putative dimer interface [polypeptide binding]; other site 114615012813 C-terminal, alpha helical domain of an unknown subfamily 3 of Glutathione S-transferases; Region: GST_C_3; cd03194 114615012814 putative substrate binding pocket (H-site) [chemical binding]; other site 114615012815 putative N-terminal domain interface [polypeptide binding]; other site 114615012816 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 114615012817 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 114615012818 active site 114615012819 catalytic tetrad [active] 114615012820 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 114615012821 non-specific DNA binding site [nucleotide binding]; other site 114615012822 salt bridge; other site 114615012823 sequence-specific DNA binding site [nucleotide binding]; other site 114615012824 Mg/Co/Ni transporter MgtE (contains CBS domain) [Inorganic ion transport and metabolism]; Region: MgtE; COG2239 114615012825 MgtE intracellular N domain; Region: MgtE_N; smart00924 114615012826 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domain in the magnesium transporter, MgtE. MgtE and its homologs are found in eubacteria, archaebacteria, and eukaryota. Members of this family transport Mg2+ or other...; Region: CBS_pair_Mg_transporter; cd04606 114615012827 Divalent cation transporter; Region: MgtE; cl00786 114615012828 Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726 114615012829 Catalytic NodB homology domain of rhizobial NodB-like proteins; Region: CE4_NodB_like_6s_7s; cd10917 114615012830 NodB motif; other site 114615012831 active site 114615012832 catalytic site [active] 114615012833 metal binding site [ion binding]; metal-binding site 114615012834 Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726 114615012835 Catalytic NodB homology domain of rhizobial NodB-like proteins; Region: CE4_NodB_like_6s_7s; cd10917 114615012836 NodB motif; other site 114615012837 active site 114615012838 catalytic site [active] 114615012839 metal binding site [ion binding]; metal-binding site 114615012840 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 114615012841 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 114615012842 hydroxyglutarate oxidase; Provisional; Region: PRK11728 114615012843 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 114615012844 homotrimer interaction site [polypeptide binding]; other site 114615012845 putative active site [active] 114615012846 amidase; Provisional; Region: PRK07486 114615012847 Amidase; Region: Amidase; pfam01425 114615012848 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 114615012849 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 114615012850 non-specific DNA binding site [nucleotide binding]; other site 114615012851 salt bridge; other site 114615012852 sequence-specific DNA binding site [nucleotide binding]; other site 114615012853 Cupin domain; Region: Cupin_2; pfam07883 114615012854 PIN (PilT N terminus) domain: Superfamily; Region: PIN_SF; cl14812 114615012855 putative active site [active] 114615012856 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 114615012857 NAD(P) binding site [chemical binding]; other site 114615012858 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 114615012859 active site 114615012860 Transcriptional regulator [Transcription]; Region: LysR; COG0583 114615012861 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 114615012862 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 114615012863 dimerization interface [polypeptide binding]; other site 114615012864 Conserved hypothetical protein (Lin0512_fam); Region: Lin0512_fam; pfam09585 114615012865 ethanolamine ammonia lyase large subunit; Provisional; Region: PRK15067 114615012866 Ethanolamine ammonia lyase large subunit (EutB); Region: EutB; pfam06751 114615012867 Ethanolamine ammonia-lyase light chain (EutC); Region: EutC; pfam05985 114615012868 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410 114615012869 ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224 114615012870 Walker A/P-loop; other site 114615012871 ATP binding site [chemical binding]; other site 114615012872 Q-loop/lid; other site 114615012873 ABC transporter signature motif; other site 114615012874 Walker B; other site 114615012875 D-loop; other site 114615012876 H-loop/switch region; other site 114615012877 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411 114615012878 ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219 114615012879 Walker A/P-loop; other site 114615012880 ATP binding site [chemical binding]; other site 114615012881 Q-loop/lid; other site 114615012882 ABC transporter signature motif; other site 114615012883 Walker B; other site 114615012884 D-loop; other site 114615012885 H-loop/switch region; other site 114615012886 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 114615012887 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 114615012888 TM-ABC transporter signature motif; other site 114615012889 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 114615012890 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 114615012891 TM-ABC transporter signature motif; other site 114615012892 Periplasmic binding protein; Region: Peripla_BP_6; pfam13458 114615012893 Periplasmic solute-binding domain of active transport proteins that belong to the type I periplasmic binding fold protein family; Region: PBP1_SBP_like_1; cd06327 114615012894 putative ligand binding site [chemical binding]; other site 114615012895 Aerobic-type carbon monoxide dehydrogenase, large subunit CoxL/CutL homologs [Energy production and conversion]; Region: CoxL; COG1529 114615012896 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; smart01008 114615012897 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 114615012898 Aerobic-type carbon monoxide dehydrogenase, small subunit CoxS/CutS homologs [Energy production and conversion]; Region: CoxS; COG2080 114615012899 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 114615012900 catalytic loop [active] 114615012901 iron binding site [ion binding]; other site 114615012902 [2Fe-2S] binding domain; Region: Fer2_2; pfam01799 114615012903 Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM/CutM homologs [Energy production and conversion]; Region: CoxM; COG1319 114615012904 CO dehydrogenase flavoprotein C-terminal domain; Region: CO_deh_flav_C; pfam03450 114615012905 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 114615012906 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 114615012907 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cl17355 114615012908 TOMM system kinase/cyclase fusion protein; Region: TOMM_kin_cyc; TIGR03903 114615012909 AAA ATPase domain; Region: AAA_16; pfam13191 114615012910 cytochrome c oxidase accessory protein FixG; Region: ccoG_rdxA_fixG; TIGR02745 114615012911 4Fe-4S binding domain; Region: Fer4_5; pfam12801 114615012912 Ubp3 associated protein Bre5; Region: Bre5; pfam11614 114615012913 Protein of unknown function (DUF2892); Region: DUF2892; pfam11127 114615012914 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 114615012915 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 114615012916 HlyD family secretion protein; Region: HlyD_3; pfam13437 114615012917 Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841 114615012918 Protein export membrane protein; Region: SecD_SecF; cl14618 114615012919 Uncharacterized homolog of gamma-carboxymuconolactone decarboxylase subunit [Function unknown]; Region: COG0599 114615012920 Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876 114615012921 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 114615012922 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 114615012923 Walker A/P-loop; other site 114615012924 ATP binding site [chemical binding]; other site 114615012925 Q-loop/lid; other site 114615012926 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 114615012927 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 114615012928 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 114615012929 dimer interface [polypeptide binding]; other site 114615012930 conserved gate region; other site 114615012931 ABC-ATPase subunit interface; other site 114615012932 nickel transporter permease NikC; Provisional; Region: nikC; PRK10417 114615012933 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 114615012934 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 114615012935 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 114615012936 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 114615012937 dimer interface [polypeptide binding]; other site 114615012938 conserved gate region; other site 114615012939 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cl01709 114615012940 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 114615012941 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 114615012942 The UbiC transcription regulator-associated (UTRA) domain is a conserved ligand-binding domain; Region: UTRA; smart00866 114615012943 dihydroxyacetone kinase subunit DhaK; Provisional; Region: PRK14481 114615012944 Dihydroxyacetone kinase [Carbohydrate transport and metabolism]; Region: DAK1; COG2376 114615012945 Phosphoenolpyruvate-protein kinase (PTS system EI component in bacteria) [Carbohydrate transport and metabolism]; Region: PtsA; COG1080 114615012946 PEP-utilising enzyme, N-terminal; Region: PEP-utilisers_N; pfam05524 114615012947 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 114615012948 PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896 114615012949 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367 114615012950 dimerization domain swap beta strand [polypeptide binding]; other site 114615012951 regulatory protein interface [polypeptide binding]; other site 114615012952 active site 114615012953 regulatory phosphorylation site [posttranslational modification]; other site 114615012954 phosphotransferase mannnose-specific family component IIA; Provisional; Region: PRK14484 114615012955 active pocket/dimerization site; other site 114615012956 active site 114615012957 phosphorylation site [posttranslational modification] 114615012958 DAK2 domain; Region: Dak2; cl03685 114615012959 ABC-type sugar transport systems, ATPase components [Carbohydrate transport and metabolism]; Region: MalK; COG3839 114615012960 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 114615012961 Walker A/P-loop; other site 114615012962 ATP binding site [chemical binding]; other site 114615012963 Q-loop/lid; other site 114615012964 ABC transporter signature motif; other site 114615012965 Walker B; other site 114615012966 D-loop; other site 114615012967 H-loop/switch region; other site 114615012968 TOBE domain; Region: TOBE_2; pfam08402 114615012969 ABC-type sugar transport systems, ATPase components [Carbohydrate transport and metabolism]; Region: MalK; COG3839 114615012970 The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301 114615012971 Walker A/P-loop; other site 114615012972 ATP binding site [chemical binding]; other site 114615012973 Q-loop/lid; other site 114615012974 ABC transporter signature motif; other site 114615012975 Walker B; other site 114615012976 D-loop; other site 114615012977 H-loop/switch region; other site 114615012978 TOBE domain; Region: TOBE_2; pfam08402 114615012979 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 114615012980 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 114615012981 dimer interface [polypeptide binding]; other site 114615012982 conserved gate region; other site 114615012983 putative PBP binding loops; other site 114615012984 ABC-ATPase subunit interface; other site 114615012985 ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555 114615012986 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 114615012987 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 114615012988 dimer interface [polypeptide binding]; other site 114615012989 conserved gate region; other site 114615012990 putative PBP binding loops; other site 114615012991 ABC-ATPase subunit interface; other site 114615012992 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 114615012993 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 114615012994 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 114615012995 Domain of unknown function (DUF4253); Region: DUF4253; pfam14062 114615012996 The (Largely Gram-negative Bacterial) Hydrophobe/Amphiphile Efflux-1 (HAE1) Family; Region: 2A0602; TIGR00915 114615012997 Protein export membrane protein; Region: SecD_SecF; cl14618 114615012998 Solute carrier families 5 and 6-like; solute binding domain; Region: SLC5-6-like_sbd; cl00456 114615012999 periplasmic multidrug efflux lipoprotein precursor; Reviewed; Region: PRK09578 114615013000 HlyD family secretion protein; Region: HlyD_3; pfam13437 114615013001 Dienelactone hydrolase and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG0412 114615013002 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 114615013003 Beta-lactamase class D [Defense mechanisms]; Region: COG2602 114615013004 Flagellar hook-length control protein FliK; Region: Flg_hook; pfam02120 114615013005 ATP12 chaperone protein; Region: ATP12; cl02228 114615013006 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 114615013007 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 114615013008 RNA binding surface [nucleotide binding]; other site 114615013009 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 114615013010 active site 114615013011 Esterase/lipase [Lipid metabolism]; Region: Aes; COG0657 114615013012 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312 114615013013 substrate binding pocket [chemical binding]; other site 114615013014 recombination factor protein RarA; Reviewed; Region: PRK13342 114615013015 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 114615013016 Walker A motif; other site 114615013017 ATP binding site [chemical binding]; other site 114615013018 Walker B motif; other site 114615013019 arginine finger; other site 114615013020 MgsA AAA+ ATPase C terminal; Region: MgsA_C; pfam12002 114615013021 periplasmic serine protease, Do/DeqQ family; Region: degP_htrA_DO; TIGR02037 114615013022 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 114615013023 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 114615013024 protein binding site [polypeptide binding]; other site 114615013025 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 114615013026 protein binding site [polypeptide binding]; other site 114615013027 Predicted transcriptional regulators [Transcription]; Region: COG1733 114615013028 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 114615013029 Arginate lyase and other MDR family members; Region: AL_MDR; cd08252 114615013030 zinc-binding alcohol dehydrogenase family protein; Region: adh_fam_1; TIGR02817 114615013031 putative NAD(P) binding site [chemical binding]; other site 114615013032 dimer interface [polypeptide binding]; other site 114615013033 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 114615013034 Beta-lactamase; Region: Beta-lactamase; pfam00144 114615013035 Phospholipid methyltransferase; Region: PEMT; pfam04191 114615013036 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 114615013037 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cl17904 114615013038 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 114615013039 NmrA-like family; Region: NmrA; pfam05368 114615013040 NAD(P) binding site [chemical binding]; other site 114615013041 active site 114615013042 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 114615013043 MarR family; Region: MarR_2; pfam12802 114615013044 Hemerythrin-like domain; Region: Hr-like; cd12108 114615013045 Fe binding site [ion binding]; other site 114615013046 Uncharacterized conserved protein [Function unknown]; Region: COG3791 114615013047 Uncharacterized homologs of Site-2 protease (S2P), zinc metalloproteases (MEROPS family M50) which cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of the...; Region: S2P-M50_like_1; cd06158 114615013048 Peptidase family M50; Region: Peptidase_M50; pfam02163 114615013049 active site 114615013050 putative substrate binding region [chemical binding]; other site 114615013051 TonB family C-terminal domain; Region: tonB_Cterm; TIGR01352 114615013052 Biopolymer transport protein ExbD/TolR; Region: ExbD; cl00537 114615013053 Biopolymer transport protein [Intracellular trafficking and secretion]; Region: ExbD; COG0848 114615013054 MotA/TolQ/ExbB proton channel family; Region: MotA_ExbB; cl00568 114615013055 Fe(II)-dependent oxygenase superfamily protein; Provisional; Region: PRK05467 114615013056 Outer membrane receptor for monomeric catechols [Inorganic ion transport and metabolism]; Region: Fiu; COG4774 114615013057 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 114615013058 N-terminal plug; other site 114615013059 ligand-binding site [chemical binding]; other site 114615013060 Transcriptional regulators [Transcription]; Region: MarR; COG1846 114615013061 MarR family; Region: MarR; pfam01047 114615013062 multidrug efflux system subunit MdtA; Provisional; Region: PRK11556 114615013063 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 114615013064 HlyD family secretion protein; Region: HlyD_3; pfam13437 114615013065 multidrug efflux system subunit MdtB; Provisional; Region: PRK10503 114615013066 Protein export membrane protein; Region: SecD_SecF; cl14618 114615013067 FOG: TPR repeat [General function prediction only]; Region: NrfG; COG0457 114615013068 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 114615013069 binding surface 114615013070 TPR motif; other site 114615013071 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 114615013072 TPR motif; other site 114615013073 binding surface 114615013074 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 114615013075 TPR motif; other site 114615013076 binding surface 114615013077 Predicted O-linked N-acetylglucosamine transferase, SPINDLY family [Posttranslational modification, protein turnover, chaperones]; Region: Spy; COG3914 114615013078 ornithine decarboxylase SpeF; Region: ODC_inducible; TIGR04301 114615013079 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily requires a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_26; cd04685 114615013080 nudix motif; other site 114615013081 The Class III extradiol dioxygenase, homoprotocatechuate 2,3-dioxygenase, catalyzes the key ring cleavage step in the metabolism of homoprotocatechuate; Region: HPCD; cd07370 114615013082 Catalytic LigB subunit of aromatic ring-opening dioxygenase; Region: LigB; pfam02900 114615013083 putative active site [active] 114615013084 putative metal binding site [ion binding]; other site 114615013085 Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071 114615013086 Alpha-crystallin domain (ACD) of alpha-crystallin-type small(s) heat shock proteins (Hsps). sHsps are small stress induced proteins with monomeric masses between 12 -43 kDa, whose common feature is the Alpha-crystallin domain (ACD). sHsps are generally...; Region: ACD_sHsps-like; cd06464 114615013087 putative dimer interface [polypeptide binding]; other site 114615013088 HerA helicase [Replication, recombination, and repair]; Region: COG0433 114615013089 Domain of unknown function DUF87; Region: DUF87; pfam01935 114615013090 transcriptional regulator SlyA; Provisional; Region: PRK03573 114615013091 MarR family; Region: MarR_2; pfam12802 114615013092 Fusaric acid resistance protein family; Region: FUSC; pfam04632 114615013093 Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515 114615013094 Protein of unknown function (DUF1656); Region: DUF1656; cl11658 114615013095 multidrug resistance protein MdtN; Provisional; Region: PRK10476 114615013096 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 114615013097 HlyD family secretion protein; Region: HlyD_3; pfam13437 114615013098 uncharacterized peroxidase-related enzyme; Region: peroxid_rel; TIGR01926 114615013099 alkylhydroperoxidase AhpD family core domain; Region: ahpD_dom; TIGR00778 114615013100 Putative ParB-like nuclease; Region: ParBc_2; cl17538 114615013101 acyl carrier protein; Provisional; Region: PRK06508 114615013102 3-hydroxymyristoyl/3-hydroxydecanoyl-(acyl carrier protein) dehydratases [Lipid metabolism]; Region: FabA; COG0764 114615013103 active site 2 [active] 114615013104 active site 1 [active] 114615013105 3-oxoacyl-(acyl carrier protein) synthase II; Reviewed; Region: PRK06519 114615013106 Condensing enzymes; Family of enzymes that catalyze a (decarboxylating or non-decarboxylating) Claisen-like condensation reaction. Members are share strong structural similarity, and are involved in the synthesis and degradation of fatty acids, and the...; Region: cond_enzymes; cl09938 114615013107 active site 114615013108 3-oxoacyl-(acyl carrier protein) synthase II; Reviewed; Region: PRK06501 114615013109 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 114615013110 dimer interface [polypeptide binding]; other site 114615013111 active site 114615013112 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LABLAT-like; Region: LPLAT_LABLAT-like; cd07984 114615013113 putative acyl-acceptor binding pocket; other site 114615013114 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_19; cd07262 114615013115 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 114615013116 putrescine transporter subunit: periplasmic-binding component of ABC superfamily; Provisional; Region: PRK10682 114615013117 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 114615013118 hypothetical protein; Provisional; Region: PRK08912 114615013119 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 114615013120 pyridoxal 5'-phosphate binding site [chemical binding]; other site 114615013121 homodimer interface [polypeptide binding]; other site 114615013122 catalytic residue [active] 114615013123 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cl00125 114615013124 active site residue [active] 114615013125 K+ transporter [Inorganic ion transport and metabolism]; Region: Kup; COG3158 114615013126 potassium uptake protein; Region: kup; TIGR00794 114615013127 K+ transporter [Inorganic ion transport and metabolism]; Region: Kup; COG3158 114615013128 potassium uptake protein; Region: kup; TIGR00794 114615013129 Flagellar motor protein [Cell motility and secretion]; Region: MotB; COG1360 114615013130 Membrane MotB of proton-channel complex MotA/MotB; Region: MotB_plug; pfam13677 114615013131 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 114615013132 ligand binding site [chemical binding]; other site 114615013133 MotA/TolQ/ExbB proton channel family; Region: MotA_ExbB; cl00568 114615013134 Flagellar motor component [Cell motility and secretion]; Region: MotA; COG1291 114615013135 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 114615013136 dimer interface [polypeptide binding]; other site 114615013137 phosphorylation site [posttranslational modification] 114615013138 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 114615013139 ATP binding site [chemical binding]; other site 114615013140 Mg2+ binding site [ion binding]; other site 114615013141 G-X-G motif; other site 114615013142 Response regulator receiver domain; Region: Response_reg; pfam00072 114615013143 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 114615013144 active site 114615013145 phosphorylation site [posttranslational modification] 114615013146 intermolecular recognition site; other site 114615013147 dimerization interface [polypeptide binding]; other site 114615013148 Demethylmenaquinone methyltransferase; Region: Methyltransf_6; cl00480 114615013149 Phosphatidylserine synthase [Lipid metabolism]; Region: PssA; COG1183 114615013150 CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; pfam01066 114615013151 phosphatidylserine decarboxylase; Provisional; Region: PRK05305 114615013152 ABC-type transport system involved in Fe-S cluster assembly, permease and ATPase components [Posttranslational modification, protein turnover, chaperones]; Region: ATM1; COG5265 114615013153 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 114615013154 ATP-binding cassette domain of iron-sulfur clusters transporter, subfamily C; Region: ABCC_ATM1_transporter; cd03253 114615013155 Walker A/P-loop; other site 114615013156 ATP binding site [chemical binding]; other site 114615013157 Q-loop/lid; other site 114615013158 ABC transporter signature motif; other site 114615013159 Walker B; other site 114615013160 D-loop; other site 114615013161 H-loop/switch region; other site 114615013162 Possible lysine decarboxylase; Region: Lysine_decarbox; cl00695 114615013163 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_19; cd07262 114615013164 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 114615013165 putative alpha-isopropylmalate/homocitrate synthase family transferase; Provisional; Region: PRK12344 114615013166 Desulfobacterium autotrophicum LeuA3 and related proteins, N-terminal catalytic TIM barrel domain; Region: DRE_TIM_LeuA3; cd07941 114615013167 active site 114615013168 catalytic residues [active] 114615013169 metal binding site [ion binding]; metal-binding site 114615013170 LeuA allosteric (dimerisation) domain; Region: LeuA_dimer; smart00917 114615013171 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 114615013172 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 114615013173 Coenzyme A binding pocket [chemical binding]; other site 114615013174 cysteinyl-tRNA synthetase; Validated; Region: cysS; PRK00260 114615013175 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 114615013176 active site 114615013177 HIGH motif; other site 114615013178 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 114615013179 KMSKS motif; other site 114615013180 Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020 114615013181 Protein of unknown function (DUF2865); Region: DUF2865; pfam11064 114615013182 Predicted amidohydrolase [General function prediction only]; Region: COG0388 114615013183 Glutamine aminotransferase (GAT, glutaminase) domain of glutamine-dependent NAD synthetases (class 7 and 8 nitrilases); Region: GAT_Gln-NAD-synth; cd07570 114615013184 multimer interface [polypeptide binding]; other site 114615013185 active site 114615013186 catalytic triad [active] 114615013187 protein interface 1 [polypeptide binding]; other site 114615013188 Adenine nucleotide alpha hydrolases superfamily including N type ATP PPases, ATP sulphurylases Universal Stress Response protein and electron transfer flavoprotein (ETF). The domain forms a apha/beta/apha fold which binds to Adenosine nucleotide; Region: AANH_like; cl00292 114615013189 Ligand Binding Site [chemical binding]; other site 114615013190 Prokaryotic diacylglycerol kinase; Region: DAGK_prokar; pfam01219 114615013191 Class-II DAHP synthetase family; Region: DAHP_synth_2; pfam01474 114615013192 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 114615013193 dimerization interface [polypeptide binding]; other site 114615013194 putative DNA binding site [nucleotide binding]; other site 114615013195 putative Zn2+ binding site [ion binding]; other site 114615013196 Putative hydrophobic ligand-binding SRPBCC domain of Micromonospora echinospora CalC, human Aha1, and related proteins; Region: SRPBCC_CalC_Aha1-like; cd07814 114615013197 putative hydrophobic ligand binding site [chemical binding]; other site 114615013198 Uncharacterized conserved protein, contains double-stranded beta-helix domain [Function unknown]; Region: COG1917 114615013199 glutathione reductase; Validated; Region: PRK06116 114615013200 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 114615013201 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 114615013202 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 114615013203 Uncharacterized protein conserved in bacteria (DUF2059); Region: DUF2059; pfam09832 114615013204 RPI_A: Ribose 5-phosphate isomerase type A (RPI_A) subfamily; RPI catalyzes the reversible conversion of ribose-5-phosphate to ribulose 5-phosphate, the first step of the non-oxidative branch of the pentose phosphate pathway. This reaction leads to the...; Region: RPI_A; cd01398 114615013205 tetramer (dimer of dimers) interface [polypeptide binding]; other site 114615013206 active site 114615013207 dimer interface [polypeptide binding]; other site 114615013208 phosphoglycolate phosphatase; Provisional; Region: PRK13222 114615013209 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 114615013210 motif II; other site 114615013211 molybdenum cofactor biosynthesis protein A; Reviewed; Region: moaA; PRK00164 114615013212 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 114615013213 FeS/SAM binding site; other site 114615013214 Molybdenum Cofactor Synthesis C; Region: Mob_synth_C; pfam06463 114615013215 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 114615013216 S-adenosylmethionine binding site [chemical binding]; other site 114615013217 Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053 114615013218 cation diffusion facilitator family transporter; Region: CDF; TIGR01297 114615013219 TRAP-type mannitol/chloroaromatic compound transport system, small permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: FcbT2; COG4665 114615013220 TRAP-type mannitol/chloroaromatic compound transport system, large permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: FcbT3; COG4664 114615013221 DctM-like transporters; Region: DctM; pfam06808 114615013222 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 114615013223 HAMP domain; Region: HAMP; pfam00672 114615013224 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 114615013225 dimer interface [polypeptide binding]; other site 114615013226 phosphorylation site [posttranslational modification] 114615013227 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 114615013228 ATP binding site [chemical binding]; other site 114615013229 Mg2+ binding site [ion binding]; other site 114615013230 G-X-G motif; other site 114615013231 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 114615013232 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 114615013233 active site 114615013234 phosphorylation site [posttranslational modification] 114615013235 intermolecular recognition site; other site 114615013236 dimerization interface [polypeptide binding]; other site 114615013237 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 114615013238 DNA binding site [nucleotide binding] 114615013239 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 114615013240 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 114615013241 HlyD family secretion protein; Region: HlyD_3; pfam13437 114615013242 Putative silver efflux pump [Inorganic ion transport and metabolism]; Region: COG3696 114615013243 efflux transporter, outer membrane factor (OMF) lipoprotein, NodT family; Region: outer_NodT; TIGR01845 114615013244 TRAP-type mannitol/chloroaromatic compound transport system, periplasmic component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: FcbT1; COG4663 114615013245 Bacterial extracellular solute-binding protein, family 7; Region: SBP_bac_7; cl15441 114615013246 TRAP-type C4-dicarboxylate transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: DctP; COG1638 114615013247 Bacterial extracellular solute-binding protein, family 7; Region: SBP_bac_7; cl15441 114615013248 Domain of unknown function DUF59; Region: DUF59; pfam01883 114615013249 MRP (Multiple Resistance and pH adaptation) is a homologue of the Fer4_NifH superfamily. Like the other members of the superfamily, MRP contains a ATP-binding domain at the N-termini. It is found in bacteria as a membrane-spanning protein and functions...; Region: MRP-like; cd02037 114615013250 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 114615013251 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_9; cd07245 114615013252 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 114615013253 dimer interface [polypeptide binding]; other site 114615013254 putative metal binding site [ion binding]; other site 114615013255 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084 114615013256 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 114615013257 Phage Tail Collar Domain; Region: Collar; pfam07484 114615013258 Phage Tail Collar Domain; Region: Collar; pfam07484 114615013259 Phage Tail Collar Domain; Region: Collar; pfam07484 114615013260 Microcystin-dependent protein [Function unknown]; Region: MdpB; COG4675 114615013261 TonB-dependent siderophore receptor; Region: TonB-siderophor; TIGR01783 114615013262 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 114615013263 N-terminal plug; other site 114615013264 ligand-binding site [chemical binding]; other site 114615013265 PepSY-associated TM helix; Region: PepSY_TM_3; pfam13706 114615013266 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 114615013267 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 114615013268 dimer interface [polypeptide binding]; other site 114615013269 phosphorylation site [posttranslational modification] 114615013270 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 114615013271 ATP binding site [chemical binding]; other site 114615013272 Mg2+ binding site [ion binding]; other site 114615013273 G-X-G motif; other site 114615013274 Protein of unknown function (DUF1289); Region: DUF1289; pfam06945 114615013275 Bacterial aspartate proteases, retropepsin-like protease family; Region: retropepsin_like_bacteria; cd05483 114615013276 catalytic motif [active] 114615013277 Catalytic residue [active] 114615013278 Histidinol-phosphate/aromatic aminotransferase and cobyric acid decarboxylase [Amino acid transport and metabolism]; Region: HisC; COG0079 114615013279 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 114615013280 pyridoxal 5'-phosphate binding site [chemical binding]; other site 114615013281 homodimer interface [polypeptide binding]; other site 114615013282 catalytic residue [active] 114615013283 tRNA-dihydrouridine synthase A; Provisional; Region: PRK11815 114615013284 Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801 114615013285 FMN binding site [chemical binding]; other site 114615013286 active site 114615013287 catalytic residues [active] 114615013288 substrate binding site [chemical binding]; other site 114615013289 Exostosin family; Region: Exostosin; pfam03016 114615013290 Uncharacterized protein involved in exopolysaccharide biosynthesis [Cell envelope biogenesis, outer membrane]; Region: GumC; COG3206 114615013291 Chain length determinant protein; Region: Wzz; cl15801 114615013292 Beta-mannanase [Carbohydrate transport and metabolism]; Region: ManB; COG4124 114615013293 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 114615013294 ExoA is involved in the biosynthesis of succinoglycan; Region: Succinoglycan_BP_ExoA; cd02525 114615013295 Ligand binding site; other site 114615013296 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 114615013297 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 114615013298 active site 114615013299 catalytic tetrad [active] 114615013300 Choline dehydrogenase and related flavoproteins [Amino acid transport and metabolism]; Region: BetA; COG2303 114615013301 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 114615013302 sugar transferase, PEP-CTERM/EpsH1 system associated; Region: stp1; TIGR03087 114615013303 Glycosyl transferases group 1; Region: Glyco_trans_1_4; pfam13692 114615013304 Bacterial sugar transferase; Region: Bac_transf; pfam02397 114615013305 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 114615013306 S-adenosylmethionine binding site [chemical binding]; other site 114615013307 Imidazolonepropionase and related amidohydrolases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: HutI; COG1228 114615013308 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 114615013309 Metallo-dependent hydrolases, subgroup A is part of the superfamily of metallo-dependent hydrolases, a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the...; Region: Met_dep_hydrolase_A; cd01299 114615013310 active site 114615013311 TRAP-type C4-dicarboxylate transport system, small permease component [Carbohydrate transport and metabolism]; Region: DctM; COG3090 114615013312 TRAP-type C4-dicarboxylate transport system, large permease component [Carbohydrate transport and metabolism]; Region: DctQ; COG1593 114615013313 TRAP-type C4-dicarboxylate transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: DctP; COG1638 114615013314 Bacterial extracellular solute-binding protein, family 7; Region: SBP_bac_7; pfam03480 114615013315 Transketolase, C-terminal subunit [Carbohydrate transport and metabolism]; Region: COG3958 114615013316 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 114615013317 PYR/PP interface [polypeptide binding]; other site 114615013318 dimer interface [polypeptide binding]; other site 114615013319 TPP binding site [chemical binding]; other site 114615013320 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 114615013321 Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012 114615013322 TPP-binding site [chemical binding]; other site 114615013323 dimer interface [polypeptide binding]; other site 114615013324 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 114615013325 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 114615013326 NAD(P) binding site [chemical binding]; other site 114615013327 active site 114615013328 DNA-binding transcriptional activator GcvA; Provisional; Region: PRK11139 114615013329 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 114615013330 The C-terminal substrate domain of LysR-type GcdR, TrPI, HvR and beta-lactamase regulators, and that of other closely related homologs; contains the type 2 periplasmic binding fold; Region: PBP2_GcdR_TrpI_HvrB_AmpR_like; cd08432 114615013331 dimerization interface [polypeptide binding]; other site 114615013332 substrate binding pocket [chemical binding]; other site 114615013333 Flavodoxin-like fold; Region: Flavodoxin_2; cl00438 114615013334 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 114615013335 Gluconolactonase [Carbohydrate transport and metabolism]; Region: COG3386 114615013336 Isochorismatase family; Region: Isochorismatase; pfam00857 114615013337 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cd00431 114615013338 catalytic triad [active] 114615013339 conserved cis-peptide bond; other site 114615013340 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 114615013341 Predicted metal-dependent hydrolase of the TIM-barrel fold [General function prediction only]; Region: COG3618 114615013342 Amidohydrolase; Region: Amidohydro_2; pfam04909 114615013343 Protein containing von Willebrand factor type A (vWA) domain [General function prediction only]; Region: CoxE; COG3552 114615013344 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198 114615013345 metal ion-dependent adhesion site (MIDAS); other site 114615013346 MoxR-like ATPases [General function prediction only]; Region: COG0714 114615013347 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 114615013348 ATP binding site [chemical binding]; other site 114615013349 Walker A motif; other site 114615013350 Walker B motif; other site 114615013351 arginine finger; other site 114615013352 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 114615013353 Aerobic-type carbon monoxide dehydrogenase, large subunit CoxL/CutL homologs [Energy production and conversion]; Region: CoxL; COG1529 114615013354 Aerobic-type carbon monoxide dehydrogenase, large subunit CoxL/CutL homologs [Energy production and conversion]; Region: CoxL; COG1529 114615013355 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; smart01008 114615013356 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 114615013357 Aerobic-type carbon monoxide dehydrogenase, small subunit CoxS/CutS homologs [Energy production and conversion]; Region: CoxS; COG2080 114615013358 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 114615013359 catalytic loop [active] 114615013360 iron binding site [ion binding]; other site 114615013361 [2Fe-2S] binding domain; Region: Fer2_2; pfam01799 114615013362 Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM/CutM homologs [Energy production and conversion]; Region: CoxM; COG1319 114615013363 CO dehydrogenase flavoprotein C-terminal domain; Region: CO_deh_flav_C; pfam03450 114615013364 Pyrabactin resistance 1 (PYR1), PYR1-like (PYL), regulatory component of abscisic acid receptors (RCARs), and related proteins; Region: PYR_PYL_RCAR_like; cd07821 114615013365 putative hydrophobic ligand binding site [chemical binding]; other site 114615013366 protein interface [polypeptide binding]; other site 114615013367 gate; other site 114615013368 Pyrabactin resistance 1 (PYR1), PYR1-like (PYL), regulatory component of abscisic acid receptors (RCARs), and related proteins; Region: PYR_PYL_RCAR_like; cd07821 114615013369 putative hydrophobic ligand binding site [chemical binding]; other site 114615013370 protein interface [polypeptide binding]; other site 114615013371 gate; other site 114615013372 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2268 114615013373 Band_7_flotillin: a subgroup of the band 7 domain of flotillin (reggie) like proteins. This subgroup contains proteins similar to stomatin, prohibitin, flotillin, HlfK/C and podicin. These two proteins are lipid raft-associated. Individual proteins of...; Region: Band_7_flotillin; cd03399 114615013374 TIM-barrel signal transduction protein; Region: TIM-br_sig_trns; pfam09370 114615013375 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410 114615013376 ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224 114615013377 Walker A/P-loop; other site 114615013378 ATP binding site [chemical binding]; other site 114615013379 Q-loop/lid; other site 114615013380 ABC transporter signature motif; other site 114615013381 Walker B; other site 114615013382 D-loop; other site 114615013383 H-loop/switch region; other site 114615013384 Uncharacterized protein family (UPF0261); Region: UPF0261; pfam06792 114615013385 hypothetical protein; Provisional; Region: PRK02399 114615013386 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411 114615013387 ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219 114615013388 Walker A/P-loop; other site 114615013389 ATP binding site [chemical binding]; other site 114615013390 Q-loop/lid; other site 114615013391 ABC transporter signature motif; other site 114615013392 Walker B; other site 114615013393 D-loop; other site 114615013394 H-loop/switch region; other site 114615013395 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 114615013396 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 114615013397 TM-ABC transporter signature motif; other site 114615013398 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 114615013399 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 114615013400 TM-ABC transporter signature motif; other site 114615013401 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 114615013402 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 114615013403 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 114615013404 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 114615013405 Periplasmic binding protein; Region: Peripla_BP_6; pfam13458 114615013406 Type I periplasmic binding component of active transport systems that are predicted be involved in anaerobic biodegradation of alkylbenzenes such as toluene and ethylbenzene; Region: PBP1_alkylbenzenes_like; cd06360 114615013407 putative ligand binding site [chemical binding]; other site 114615013408 Periplasmic sugar-binding component of uncharacterized ABC-type transport systems that are members of the pentose/hexose sugar-binding protein family of the type I periplasmic binding protein superfamily; Region: PBP1_ABC_sugar_binding_like_1; cd06300 114615013409 Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407 114615013410 putative ligand binding site [chemical binding]; other site 114615013411 ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129 114615013412 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 114615013413 Walker A/P-loop; other site 114615013414 ATP binding site [chemical binding]; other site 114615013415 Q-loop/lid; other site 114615013416 ABC transporter signature motif; other site 114615013417 Walker B; other site 114615013418 D-loop; other site 114615013419 H-loop/switch region; other site 114615013420 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 114615013421 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 114615013422 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 114615013423 TM-ABC transporter signature motif; other site 114615013424 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 114615013425 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 114615013426 TM-ABC transporter signature motif; other site 114615013427 glycerol-3-phosphate dehydrogenase; Provisional; Region: PRK13369 114615013428 Class II Aldolase and Adducin head (N-terminal) domain. Aldolases are ubiquitous enzymes catalyzing central steps of carbohydrate metabolism. Based on enzymatic mechanisms, this superfamily has been divided into two distinct classes (Class I and II); Region: Aldolase_II; cl00214 114615013429 intersubunit interface [polypeptide binding]; other site 114615013430 active site 114615013431 Zn2+ binding site [ion binding]; other site 114615013432 Phosphoglycerate dehydrogenase and related dehydrogenases [Amino acid transport and metabolism]; Region: SerA; COG0111 114615013433 Putative D-isomer specific 2-hydroxyacid dehydrogenases; Region: 2-Hacid_dh_10; cd12171 114615013434 putative ligand binding site [chemical binding]; other site 114615013435 putative NAD binding site [chemical binding]; other site 114615013436 catalytic site [active] 114615013437 Sugar (pentulose and hexulose) kinases [Carbohydrate transport and metabolism]; Region: XylB; COG1070 114615013438 L-xylulose kinases; a subfamily of the FGGY family of carbohydrate kinases; Region: FGGY_L-XK; cd07802 114615013439 putative N- and C-terminal domain interface [polypeptide binding]; other site 114615013440 putative active site [active] 114615013441 MgATP binding site [chemical binding]; other site 114615013442 catalytic site [active] 114615013443 metal binding site [ion binding]; metal-binding site 114615013444 putative xylulose binding site [chemical binding]; other site 114615013445 ABC-type sugar transport systems, ATPase components [Carbohydrate transport and metabolism]; Region: MalK; COG3839 114615013446 ATP-binding cassette domain of the carbohydrate and solute transporters-like; Region: ABC_Carb_Solutes_like; cd03259 114615013447 Walker A/P-loop; other site 114615013448 ATP binding site [chemical binding]; other site 114615013449 Q-loop/lid; other site 114615013450 ABC transporter signature motif; other site 114615013451 Walker B; other site 114615013452 D-loop; other site 114615013453 H-loop/switch region; other site 114615013454 TOBE domain; Region: TOBE_2; pfam08402 114615013455 ABC-type sugar transport systems, ATPase components [Carbohydrate transport and metabolism]; Region: MalK; COG3839 114615013456 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 114615013457 Walker A/P-loop; other site 114615013458 ATP binding site [chemical binding]; other site 114615013459 Q-loop/lid; other site 114615013460 ABC transporter signature motif; other site 114615013461 Walker B; other site 114615013462 D-loop; other site 114615013463 H-loop/switch region; other site 114615013464 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 114615013465 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 114615013466 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 114615013467 dimer interface [polypeptide binding]; other site 114615013468 conserved gate region; other site 114615013469 putative PBP binding loops; other site 114615013470 ABC-ATPase subunit interface; other site 114615013471 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 114615013472 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 114615013473 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 114615013474 Transcriptional regulator, contains sigma factor-related N-terminal domain [Transcription]; Region: DeoR; COG2390 114615013475 Putative sugar-binding domain; Region: Sugar-bind; pfam04198 114615013476 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 114615013477 D-xylulose kinase; Region: XylB; TIGR01312 114615013478 nucleotide binding site [chemical binding]; other site 114615013479 HAD-superfamily class IIA hydrolase, TIGR01459; Region: HAD-SF-IIA-hyp4 114615013480 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 114615013481 active site 114615013482 motif I; other site 114615013483 motif II; other site 114615013484 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 114615013485 Uncharacterized conserved protein [Function unknown]; Region: COG3347 114615013486 Class II Aldolase and Adducin N-terminal domain; Region: Aldolase_II; pfam00596 114615013487 SnoaL-like polyketide cyclase; Region: SnoaL; pfam07366 114615013488 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 114615013489 Glutathione S-transferase (GST) family, N-terminal domain; a large, diverse group of cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of endogenous and xenobiotic...; Region: GST_N_family; cd00570 114615013490 C-terminal domain interface [polypeptide binding]; other site 114615013491 GSH binding site (G-site) [chemical binding]; other site 114615013492 dimer interface [polypeptide binding]; other site 114615013493 Glutathione S-transferase, C-terminal domain; Region: GST_C_2; pfam13410 114615013494 short chain dehydrogenase; Provisional; Region: PRK12939 114615013495 classical (c) SDRs; Region: SDR_c; cd05233 114615013496 NAD(P) binding site [chemical binding]; other site 114615013497 active site 114615013498 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 114615013499 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 114615013500 C-terminal, alpha helical domain of the Glutathione S-transferase family; Region: GST_C_family; cl02776 114615013501 N-terminal domain interface [polypeptide binding]; other site 114615013502 Periplasmic binding protein; Region: Peripla_BP_6; pfam13458 114615013503 Periplasmic solute-binding domain of active transport proteins that belong to the type I periplasmic binding fold protein family; Region: PBP1_SBP_like_1; cd06327 114615013504 putative ligand binding site [chemical binding]; other site 114615013505 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 114615013506 CoA-transferase family III; Region: CoA_transf_3; pfam02515 114615013507 DNA-binding transcriptional activator XapR; Provisional; Region: PRK09986 114615013508 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 114615013509 The C-terminal substrate binding domain of LysR-type transcrptional regulator BudR, which is responsible for activation of the expression of the butanediol operon genes; contains the type 2 periplasmic binding fold; Region: PBP2_BudR; cd08451 114615013510 putative dimerization interface [polypeptide binding]; other site 114615013511 putative substrate binding pocket [chemical binding]; other site 114615013512 Chain length determinant protein; Region: Wzz; pfam02706 114615013513 Uncharacterized protein involved in exopolysaccharide biosynthesis [Cell envelope biogenesis, outer membrane]; Region: GumC; COG3206 114615013514 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Mrp; COG0489 114615013515 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 114615013516 The glycosyltransferase WecG/TagA superfamily contains Escherichia coli WecG, Bacillus subtilis TagA and related proteins. E. coli WecG is believed to be a UDP-N-acetyl-D-mannosaminuronic acid transferase, and is involved in enterobacterial common...; Region: Glyco_transf_WecG_TagA; cd06533 114615013517 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 114615013518 anti sigma factor interaction site; other site 114615013519 regulatory phosphorylation site [posttranslational modification]; other site 114615013520 Lipid A core - O-antigen ligase and related enzymes [Cell envelope biogenesis, outer membrane]; Region: RfaL; COG3307 114615013521 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 114615013522 CESA_like is the cellulose synthase superfamily; Region: CESA_like; cd06423 114615013523 DXD motif; other site 114615013524 Predicted acyltransferases [Lipid metabolism]; Region: COG1835 114615013525 ATP-grasp domain; Region: ATP-grasp_4; pfam13535 114615013526 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 114615013527 exosortase A system-associated amidotransferase 1; Region: eps_aminotran_1; TIGR03108 114615013528 Glutamine amidotransferases class-II (GATase) asparagine synthase_B type. Asparagine synthetase B catalyses the ATP-dependent conversion of aspartate to asparagine. This enzyme is a homodimer, with each monomer composed of a glutaminase domain and a...; Region: AsnB; cd00712 114615013529 active site 114615013530 dimer interface [polypeptide binding]; other site 114615013531 The C-terminal domain of Asparagine Synthase B. This domain is always found associated n-terminal amidotransferase domain. Family members that contain this domain catalyse the conversion of aspartate to asparagine. Asparagine synthetase B catalyzes the...; Region: Asn_Synthase_B_C; cd01991 114615013532 Ligand Binding Site [chemical binding]; other site 114615013533 Molecular Tunnel; other site 114615013534 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 114615013535 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 114615013536 NAD(P) binding site [chemical binding]; other site 114615013537 active site 114615013538 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 114615013539 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 114615013540 sugar transferase, PEP-CTERM/EpsH1 system associated; Region: stp1; TIGR03087 114615013541 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 114615013542 Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; Region: MATE_tuaB_like; cd13127 114615013543 Glycosyl transferases group 1; Region: Glyco_trans_1_2; pfam13524 114615013544 M28 Zn-Peptidases; Region: M28_like_3; cd05644 114615013545 Domain of unknown function (DUF2172); Region: DUF2172; pfam09940 114615013546 active site 114615013547 metal binding site [ion binding]; metal-binding site 114615013548 dTDP-4-dehydrorhamnose 3,5-epimerase; Region: dTDP_sugar_isom; cl17405 114615013549 Putative zinc binding domain; Region: Methyltransf_13; pfam08421 114615013550 Methyltransferase domain; Region: Methyltransf_23; pfam13489 114615013551 Methyltransferase domain; Region: Methyltransf_12; pfam08242 114615013552 C-methyltransferase C-terminal domain; Region: Methyltransf_14; pfam08484 114615013553 NAD dependent epimerase/dehydratase family; Region: Epimerase; pfam01370 114615013554 extended (e) SDRs; Region: SDR_e; cd08946 114615013555 NAD(P) binding site [chemical binding]; other site 114615013556 active site 114615013557 substrate binding site [chemical binding]; other site 114615013558 Uncharacterized proteins, LmbE homologs [Function unknown]; Region: COG2120 114615013559 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis/translation initiation factor 2B, gamma/epsilon subunits (eIF-2Bgamma/eIF-2Bepsilon) [Cell envelope biogenesis, outer membrane / Translation, ribosomal structure...; Region: GCD1; COG1208 114615013560 G1P_cytidylyltransferase catalyzes the production of CDP-D-Glucose; Region: G1P_cytidylyltransferase; cd02524 114615013561 substrate binding site; other site 114615013562 Undecaprenyl-phosphate glucose phosphotransferase; Region: WcaJ_sugtrans; TIGR03023 114615013563 Bacterial sugar transferase; Region: Bac_transf; pfam02397 114615013564 H-NS histone family; Region: Histone_HNS; pfam00816 114615013565 Domain in histone-like proteins of HNS family; Region: HNS; smart00528 114615013566 polysaccharide export protein EpsE; Region: EpsE; TIGR03028 114615013567 Polysaccharide biosynthesis/export protein; Region: Poly_export; pfam02563 114615013568 SLBB domain; Region: SLBB; pfam10531 114615013569 Dopa 4,5-dioxygenase family; Region: DOPA_dioxygen; pfam08883 114615013570 Predicted amidohydrolase [General function prediction only]; Region: COG0388 114615013571 First nitrilase domain of an uncharacterized subgroup of the nitrilase superfamily (putative class 13 nitrilases); Region: nitrilase_1_R1; cd07578 114615013572 putative active site [active] 114615013573 catalytic triad [active] 114615013574 putative dimer interface [polypeptide binding]; other site 114615013575 Second nitrilase domain of an uncharacterized subgroup of the nitrilase superfamily (putative class 13 nitrilases); Region: nitrilase_1_R2; cd07579 114615013576 Predicted amidohydrolase [General function prediction only]; Region: COG0388 114615013577 putative active site [active] 114615013578 catalytic triad [active] 114615013579 putative dimer interface [polypeptide binding]; other site 114615013580 Predicted acetamidase/formamidase [Energy production and conversion]; Region: COG2421 114615013581 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410 114615013582 ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224 114615013583 Walker A/P-loop; other site 114615013584 ATP binding site [chemical binding]; other site 114615013585 Q-loop/lid; other site 114615013586 ABC transporter signature motif; other site 114615013587 Walker B; other site 114615013588 D-loop; other site 114615013589 H-loop/switch region; other site 114615013590 urea ABC transporter, ATP-binding protein UrtD; Region: urea_trans_UrtD; TIGR03411 114615013591 ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219 114615013592 Walker A/P-loop; other site 114615013593 ATP binding site [chemical binding]; other site 114615013594 Q-loop/lid; other site 114615013595 ABC transporter signature motif; other site 114615013596 Walker B; other site 114615013597 D-loop; other site 114615013598 H-loop/switch region; other site 114615013599 ABC-type branched-chain amino acid transport system, permease component [Amino acid transport and metabolism]; Region: LivM; COG4177 114615013600 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 114615013601 TM-ABC transporter signature motif; other site 114615013602 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 114615013603 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 114615013604 TM-ABC transporter signature motif; other site 114615013605 Periplasmic binding protein; Region: Peripla_BP_6; pfam13458 114615013606 Periplasmic component (FmdD) of an active transport system for short-chain amides and urea (FmdDEF); Region: PBP1_Amide_Urea_BP_like; cd06356 114615013607 putative ligand binding site [chemical binding]; other site 114615013608 Response regulator with putative antiterminator output domain [Signal transduction mechanisms]; Region: AmiR; COG3707 114615013609 ANTAR domain; Region: ANTAR; cl04297 114615013610 Periplasmic binding domain of amidase (AmiC) that belongs to the type I periplasmic binding fold protein family; Region: PBP1_AmiC; cd06357 114615013611 Periplasmic binding protein; Region: Peripla_BP_6; pfam13458 114615013612 ligand binding site [chemical binding]; other site 114615013613 regulator interaction site; other site 114615013614 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_9; cd04666 114615013615 nudix motif; other site 114615013616 Tannase and feruloyl esterase; Region: Tannase; pfam07519 114615013617 FMN-dependent oxidoreductase, nitrilotriacetate monooxygenase family; Region: FMN_nitrolo; TIGR03860 114615013618 nitrilotriacetate monoxygenase oxidizes nitrilotriacetate utilizing reduced flavin mononucleotide (FMNH2) and oxygen. The FMNH2 is provided by an NADH:flavin mononucleotide (FMN) oxidorductase that uses NADH to reduce FMN to FMNH2; Region: Nitrilotriacetate_monoxgenase; cd01095 114615013619 active site 114615013620 non-prolyl cis peptide bond; other site 114615013621 Asp/Glu/Hydantoin racemase; Region: Asp_Glu_race; cl00518 114615013622 Predicted O-methyltransferase [General function prediction only]; Region: COG4122 114615013623 Methyltransferase domain; Region: Methyltransf_24; pfam13578 114615013624 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 114615013625 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 114615013626 ABC transporter, substrate-binding protein, aliphatic sulfonates family; Region: SsuA_fam; TIGR01728 114615013627 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 114615013628 substrate binding pocket [chemical binding]; other site 114615013629 membrane-bound complex binding site; other site 114615013630 hinge residues; other site 114615013631 Nitroreductase-like family 2. A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes, nitrofurans and...; Region: Nitroreductase_2; cd02138 114615013632 putative FMN binding site [chemical binding]; other site 114615013633 O-acetylhomoserine aminocarboxypropyltransferase; Validated; Region: PRK08134 114615013634 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 114615013635 homodimer interface [polypeptide binding]; other site 114615013636 substrate-cofactor binding pocket; other site 114615013637 pyridoxal 5'-phosphate binding site [chemical binding]; other site 114615013638 catalytic residue [active] 114615013639 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 114615013640 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 114615013641 BAAT / Acyl-CoA thioester hydrolase C terminal; Region: BAAT_C; pfam08840 114615013642 BA14K-like protein; Region: BA14K; pfam07886 114615013643 Heme/copper-type cytochrome/quinol oxidases, subunit 1 [Energy production and conversion]; Region: CyoB; COG0843 114615013644 Ubiquinol oxidase subunit I. Ubiquinol oxidase, the terminal oxidase in the respiratory chains of aerobic bacteria, is a multi-chain transmembrane protein located in the cell membrane. It catalyzes the reduction of O2 and simultaneously pumps protons...; Region: Ubiquinol_Oxidase_I; cd01662 114615013645 D-pathway; other site 114615013646 Putative ubiquinol binding site [chemical binding]; other site 114615013647 Low-spin heme (heme b) binding site [chemical binding]; other site 114615013648 Putative water exit pathway; other site 114615013649 Binuclear center (heme o3/CuB) [ion binding]; other site 114615013650 K-pathway; other site 114615013651 Putative proton exit pathway; other site 114615013652 Domain of unknown function (DUF4336); Region: DUF4336; pfam14234 114615013653 short chain dehydrogenase; Provisional; Region: PRK06139 114615013654 classical (c) SDR, subgroup 3; Region: SDR_c3; cd05360 114615013655 putative NAD(P) binding site [chemical binding]; other site 114615013656 active site 114615013657 flagellar hook-associated protein FlgL; Validated; Region: flgL; PRK08913 114615013658 Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669 114615013659 flagellar hook-associated protein FlgK; Region: flgK_ends; TIGR02492 114615013660 flagellar hook-associated protein FlgK; Validated; Region: flgK; PRK08471 114615013661 flagellar hook protein FlgE; Validated; Region: flgE; PRK05682 114615013662 Flagellar basal body protein FlaE; Region: FlaE; pfam07559 114615013663 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; cl15855 114615013664 Flagellar hook capping protein - N-terminal region; Region: FlgD; pfam03963 114615013665 FlgD Tudor-like domain; Region: FLgD_tudor; pfam13861 114615013666 Flagellar protein FliS; Region: FliS; cl00654 114615013667 Flagellar hook-associated protein 2 C-terminus; Region: FliD_N; pfam02465 114615013668 Flagellar hook-associated protein 2 C-terminus; Region: FliD_C; pfam07195 114615013669 flagellin; Provisional; Region: PRK12804 114615013670 Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669 114615013671 Bacterial flagellin C-terminal helical region; Region: Flagellin_C; pfam00700 114615013672 RNA polymerase sigma factor; Provisional; Region: PRK12538 114615013673 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 114615013674 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 114615013675 DNA binding residues [nucleotide binding] 114615013676 Formyltransferase, catalytic core domain; Region: FMT_core; cl00395 114615013677 active site 114615013678 cosubstrate binding site; other site 114615013679 substrate binding site [chemical binding]; other site 114615013680 catalytic site [active] 114615013681 Proteins of this family catalyze the reduction of flavin or nitrocompounds using NAD(P)H as electron donor in a obligatory two-electron transfer, utilizing FMN or FAD as cofactor. They are often found to be homodimers. Enzymes of this family are...; Region: Nitro_FMN_reductase; cl00514 114615013682 FMN binding site [chemical binding]; other site 114615013683 dimer interface [polypeptide binding]; other site 114615013684 cobyrinic acid a,c-diamide synthase; Validated; Region: PRK01077 114615013685 Type 1 glutamine amidotransferase (GATase1) domain found in Cobyrinic Acid a,c-Diamide Synthase; Region: GATase1_CobB; cd03130 114615013686 cobalt-precorrin-6A synthase; Reviewed; Region: cbiD; PRK00075 114615013687 Precorrin-4 C11-methyltransferase (CbiF/CobM); Region: Precorrin-4_C11-MT; cd11641 114615013688 active site 114615013689 SAM binding site [chemical binding]; other site 114615013690 homodimer interface [polypeptide binding]; other site 114615013691 Cobalamin synthesis G C-terminus; Region: CbiG_C; pfam01890 114615013692 Precorrin-6Y methyltransferase, the cobalamin biosynthesis enzyme CbiE; Region: Precorrin-6Y-methylase; cd11644 114615013693 active site 114615013694 putative homodimer interface [polypeptide binding]; other site 114615013695 SAM binding site [chemical binding]; other site 114615013696 Precorrin-6B methylase 2 [Coenzyme metabolism]; Region: CobL; COG2242 114615013697 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 114615013698 S-adenosylmethionine binding site [chemical binding]; other site 114615013699 Precorrin-6x reductase [Coenzyme metabolism]; Region: CobK; COG2099 114615013700 Precorrin-6x reductase CbiJ/CobK; Region: CbiJ; pfam02571 114615013701 Precorrin-3B C(17)-methyltransferase (CobJ/CbiH); Region: Precorrin_3B_C17_MT; cd11646 114615013702 active site 114615013703 SAM binding site [chemical binding]; other site 114615013704 homodimer interface [polypeptide binding]; other site 114615013705 Precorrin-2 C20-methyltransferase, also named CobI or CbiL; Region: Precorrin_2_C20_MT; cd11645 114615013706 active site 114615013707 SAM binding site [chemical binding]; other site 114615013708 homodimer interface [polypeptide binding]; other site 114615013709 precorrin-8X methylmutase; Reviewed; Region: cobH; PRK08285 114615013710 Precorrin-8X methylmutase; Region: CbiC; pfam02570 114615013711 precorrin-3B synthase; Region: CobG; TIGR02435 114615013712 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 114615013713 cobaltochelatase subunit CobN; Reviewed; Region: cobN; PRK12321 114615013714 CobN subunit of cobaltochelatase, bchH and chlH subunits of magnesium chelatases, and similar proteins; Region: CobN_like; cd10150 114615013715 cobalamin biosynthesis protein CobW; Region: CobW; TIGR02475 114615013716 CobW/HypB/UreG, nucleotide-binding domain; Region: cobW; pfam02492 114615013717 Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; pfam07683 114615013718 Protein of unknown function (DUF1636); Region: DUF1636; pfam07845 114615013719 HupE / UreJ protein; Region: HupE_UreJ; cl01011 114615013720 Adenosylcobinamide kinase / adenosylcobinamide phosphate guanyltransferase (CobU). CobU is bifunctional cobalbumin biosynthesis enzymes which display adenosylcobinamide kinase and adenosylcobinamide phosphate guanyltransferase activity. This enzyme is a...; Region: CobU; cd00544 114615013721 homotrimer interface [polypeptide binding]; other site 114615013722 Walker A motif; other site 114615013723 GTP binding site [chemical binding]; other site 114615013724 Walker B motif; other site 114615013725 Cob(I)alamin adenosyltransferase N terminal; Region: Co_AT_N; pfam12557 114615013726 ATP:corrinoid adenosyltransferase [Coenzyme metabolism]; Region: BtuR; COG2109 114615013727 ATP:corrinoid adenosyltransferase BtuR/CobO/CobP. This family consists of the BtuR, CobO, CobP proteins all of which are Cob(I)alamin (vitamin B12) adenosyltransferase, which is involved in cobalamin (vitamin B12) biosynthesis. This enzyme is a homodimer; Region: CobA_CobO_BtuR; cd00561 114615013728 homodimer interface [polypeptide binding]; other site 114615013729 Walker A motif; other site 114615013730 ATP binding site [chemical binding]; other site 114615013731 hydroxycobalamin binding site [chemical binding]; other site 114615013732 Walker B motif; other site 114615013733 cobyric acid synthase; Provisional; Region: PRK00784 114615013734 Type 1 glutamine amidotransferase (GATase1) domain found in Cobyric Acid Synthase (CobQ); Region: GATase1_CobQ; cd01750 114615013735 catalytic triad [active] 114615013736 CobD/Cbib protein; Region: CobD_Cbib; pfam03186 114615013737 L-threonine-O-3-phosphate decarboxylase; Region: L_thr_O3P_dcar; TIGR01140 114615013738 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 114615013739 pyridoxal 5'-phosphate binding site [chemical binding]; other site 114615013740 homodimer interface [polypeptide binding]; other site 114615013741 catalytic residue [active] 114615013742 cobalamin synthase; Reviewed; Region: cobS; PRK00235 114615013743 Histidine phosphatase domain found in a functionally diverse set of proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP; cd07040 114615013744 catalytic core [active] 114615013745 Phosphoribosyltransferase; Region: DBI_PRT; pfam02277 114615013746 Nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase (DMB-PRT), also called CobT; Region: DMB-PRT_CobT; cd02439 114615013747 putative dimer interface [polypeptide binding]; other site 114615013748 active site pocket [active] 114615013749 putative cataytic base [active] 114615013750 Orn/Lys/Arg decarboxylase, N-terminal domain; Region: OKR_DC_1_N; pfam03709 114615013751 ornithine decarboxylase; Provisional; Region: PRK13578 114615013752 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 114615013753 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 114615013754 catalytic residue [active] 114615013755 Orn/Lys/Arg decarboxylase, C-terminal domain; Region: OKR_DC_1_C; pfam03711 114615013756 Sortase and related acyltransferases [Cell envelope biogenesis, outer membrane]; Region: COG1247 114615013757 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 114615013758 Coenzyme A binding pocket [chemical binding]; other site 114615013759 Phosphoglycerate dehydrogenase and related dehydrogenases [Amino acid transport and metabolism]; Region: SerA; COG0111 114615013760 Phosphoglycerate dehydrogenases, NAD-binding and catalytic domains; Region: PGDH_4; cd12173 114615013761 ligand binding site [chemical binding]; other site 114615013762 NAD binding site [chemical binding]; other site 114615013763 dimerization interface [polypeptide binding]; other site 114615013764 catalytic site [active] 114615013765 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 114615013766 PYR/PP interface [polypeptide binding]; other site 114615013767 dimer interface [polypeptide binding]; other site 114615013768 TPP binding site [chemical binding]; other site 114615013769 hypothetical protein; Provisional; Region: PRK06163 114615013770 Thiamine pyrophosphate (TPP) family, ComE subfamily, TPP-binding module; composed of proteins similar to Methanococcus jannaschii sulfopyruvate decarboxylase beta subunit (ComE). M. jannaschii sulfopyruvate decarboxylase (ComDE) is a dodecamer of six...; Region: TPP_ComE; cd03372 114615013771 TPP-binding site; other site 114615013772 Protein of unknown function (DUF1236); Region: DUF1236; pfam06823 114615013773 lysyl-tRNA synthetase; Provisional; Region: lysS; PRK02983 114615013774 GST_N family, Saccharomyces cerevisiae GTT1-like subfamily; composed of predominantly uncharacterized proteins with similarity to the S. cerevisiae GST protein, GTT1, and the Schizosaccharomyces pombe GST-III. GSTs are cytosolic dimeric proteins involved...; Region: GST_N_GTT1_like; cd03046 114615013775 putative C-terminal domain interface [polypeptide binding]; other site 114615013776 putative GSH binding site (G-site) [chemical binding]; other site 114615013777 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 114615013778 putative dimer interface [polypeptide binding]; other site 114615013779 C-terminal, alpha helical domain of the Glutathione S-transferase family; Region: GST_C_family; cl02776 114615013780 4-hydroxyphenylacetate permease; Region: HpaX; TIGR02332 114615013781 FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790 114615013782 Sel1 repeat; Region: Sel1; pfam08238 114615013783 stage V sporulation protein K; Region: spore_V_K; TIGR02881 114615013784 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 114615013785 Walker A motif; other site 114615013786 ATP binding site [chemical binding]; other site 114615013787 Walker B motif; other site 114615013788 arginine finger; other site 114615013789 stage V sporulation protein K; Region: spore_V_K; TIGR02881 114615013790 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 114615013791 Walker A motif; other site 114615013792 ATP binding site [chemical binding]; other site 114615013793 Walker B motif; other site 114615013794 arginine finger; other site 114615013795 Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]; Region: DegQ; COG0265 114615013796 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 114615013797 hydroxypyruvate isomerase; Region: OH-pyruv-isom; TIGR03234 114615013798 glyoxylate carboligase; Provisional; Region: PRK11269 114615013799 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 114615013800 PYR/PP interface [polypeptide binding]; other site 114615013801 dimer interface [polypeptide binding]; other site 114615013802 TPP binding site [chemical binding]; other site 114615013803 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 114615013804 Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cl01629 114615013805 TPP-binding site [chemical binding]; other site 114615013806 Adenine deaminase [Nucleotide transport and metabolism]; Region: AdeC; COG1001 114615013807 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 114615013808 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 114615013809 active site 114615013810 Adenine deaminase C-terminal domain; Region: Adenine_deam_C; pfam13382 114615013811 transcriptional repressor IclR; Provisional; Region: PRK11569 114615013812 helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346 114615013813 Bacterial transcriptional regulator; Region: IclR; pfam01614 114615013814 Acyl-CoA synthetase (NDP forming) [Energy production and conversion]; Region: COG1042 114615013815 ATP-grasp domain; Region: ATP-grasp_5; pfam13549 114615013816 acetyl coenzyme A synthetase (ADP forming), alpha domain; Region: AcCoA-syn-alpha; TIGR02717 114615013817 CoA binding domain; Region: CoA_binding_2; pfam13380 114615013818 Succinyl-CoA ligase like flavodoxin domain; Region: Succ_CoA_lig; pfam13607 114615013819 Transcriptional regulators [Transcription]; Region: GntR; COG1802 114615013820 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 114615013821 DNA-binding site [nucleotide binding]; DNA binding site 114615013822 FCD domain; Region: FCD; pfam07729 114615013823 putative oxalyl-CoA decarboxylase; Validated; Region: PRK09259 114615013824 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 114615013825 PYR/PP interface [polypeptide binding]; other site 114615013826 dimer interface [polypeptide binding]; other site 114615013827 TPP binding site [chemical binding]; other site 114615013828 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 114615013829 Thiamine pyrophosphate (TPP) family, BZL_OCoD_HPCL subfamily, TPP-binding module; composed of proteins similar to benzaldehyde lyase (BZL), oxalyl-CoA decarboxylase (OCoD) and 2-hydroxyphytanoyl-CoA lyase (2-HPCL). Pseudomonas fluorescens biovar I BZL...; Region: TPP_BZL_OCoD_HPCL; cd02004 114615013830 TPP-binding site; other site 114615013831 dimer interface [polypeptide binding]; other site 114615013832 formyl-coenzyme A transferase; Provisional; Region: PRK05398 114615013833 CoA-transferase family III; Region: CoA_transf_3; pfam02515 114615013834 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 114615013835 Uncharacterized membrane-anchored protein conserved in bacteria [Function unknown]; Region: COG4705 114615013836 Repeat of Unknown Function (DUF347); Region: DUF347; pfam03988 114615013837 Repeat of Unknown Function (DUF347); Region: DUF347; pfam03988 114615013838 Repeat of Unknown Function (DUF347); Region: DUF347; pfam03988 114615013839 oxalate/formate antiporter; Region: oxa_formateAnti; TIGR04259 114615013840 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 114615013841 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 114615013842 putative substrate translocation pore; other site 114615013843 oxalate/formate antiporter; Region: oxa_formateAnti; TIGR04259 114615013844 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 114615013845 putative substrate translocation pore; other site 114615013846 FOG: CBS domain [General function prediction only]; Region: COG0517 114615013847 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354 114615013848 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 114615013849 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 114615013850 NAD(P) binding site [chemical binding]; other site 114615013851 Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053 114615013852 Cation efflux family; Region: Cation_efflux; cl00316 114615013853 Cation efflux family; Region: Cation_efflux; cl00316 114615013854 Cation efflux family; Region: Cation_efflux; cl00316 114615013855 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459 114615013856 PAS fold; Region: PAS_3; pfam08447 114615013857 putative active site [active] 114615013858 heme pocket [chemical binding]; other site 114615013859 PAS fold; Region: PAS_7; pfam12860 114615013860 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 114615013861 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 114615013862 dimer interface [polypeptide binding]; other site 114615013863 phosphorylation site [posttranslational modification] 114615013864 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 114615013865 ATP binding site [chemical binding]; other site 114615013866 Mg2+ binding site [ion binding]; other site 114615013867 G-X-G motif; other site 114615013868 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3666 114615013869 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 114615013870 Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751 114615013871 Protein of unknown function (DUF4240); Region: DUF4240; pfam14024 114615013872 Predicted transporter component [General function prediction only]; Region: COG2391 114615013873 Sulphur transport; Region: Sulf_transp; pfam04143 114615013874 Transcriptional regulator [Transcription]; Region: LysR; COG0583 114615013875 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 114615013876 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 114615013877 dimerization interface [polypeptide binding]; other site 114615013878 formate dehydrogenase subunit gamma; Validated; Region: PRK05988 114615013879 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 114615013880 TRX-like [2Fe-2S] Ferredoxin (Fd) family, NAD-dependent formate dehydrogenase (FDH) beta subunit; composed of proteins similar to the beta subunit of NAD-linked FDH of Ralstonia eutropha, a soluble enzyme that catalyzes the irreversible oxidation of...; Region: TRX_Fd_FDH_beta; cd03063 114615013881 putative dimer interface [polypeptide binding]; other site 114615013882 NADH:ubiquinone oxidoreductase, NADH-binding (51 kD) subunit [Energy production and conversion]; Region: NuoF; COG1894 114615013883 SLBB domain; Region: SLBB; pfam10531 114615013884 NADH-ubiquinone oxidoreductase-F iron-sulfur binding region; Region: NADH_4Fe-4S; smart00928 114615013885 Uncharacterized anaerobic dehydrogenase [General function prediction only]; Region: COG3383 114615013886 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 114615013887 catalytic loop [active] 114615013888 iron binding site [ion binding]; other site 114615013889 NADH-ubiquinone oxidoreductase-G iron-sulfur binding region; Region: NADH-G_4Fe-4S_3; pfam10588 114615013890 Formate dehydrogenase H (Formate-Dh-H) catalyzes the reversible oxidation of formate to CO2 with the release of a proton and two electrons. It is a component of the anaerobic formate hydrogen lyase complex. The E. coli formate dehydrogenase H (Fdh-H) is...; Region: MopB_Formate-Dh-H; cd02753 114615013891 [4Fe-4S] binding site [ion binding]; other site 114615013892 molybdopterin cofactor binding site; other site 114615013893 This CD includes formate dehydrogenases (Fdh) H and N; nitrate reductases, Nap and Nas; and other related proteins. Formate dehydrogenase H is a component of the anaerobic formate hydrogen lyase complex and catalyzes the reversible oxidation of formate...; Region: MopB_CT_Fdh-Nap-like; cd00508 114615013894 molybdopterin cofactor binding site; other site 114615013895 formate dehydrogenase accessory protein; Reviewed; Region: PRK00724 114615013896 NADH-dependant formate dehydrogenase delta subunit FdsD; Region: FdsD; pfam11390 114615013897 Ion transport protein; Region: Ion_trans; pfam00520 114615013898 Ion channel; Region: Ion_trans_2; pfam07885 114615013899 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 114615013900 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 114615013901 ligand binding site [chemical binding]; other site 114615013902 flexible hinge region; other site 114615013903 alanyl-tRNA synthetase; Reviewed; Region: alaS; PRK00252 114615013904 Alanyl-tRNA synthetase (AlaRS) class II core catalytic domain. AlaRS is a homodimer. It is responsible for the attachment of alanine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: AlaRS_core; cd00673 114615013905 motif 1; other site 114615013906 active site 114615013907 motif 2; other site 114615013908 motif 3; other site 114615013909 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863 114615013910 DHHA1 domain; Region: DHHA1; pfam02272 114615013911 glycine cleavage system aminomethyltransferase T; Provisional; Region: gcvT; PRK13579 114615013912 Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669 114615013913 Glycine cleavage H-protein. Glycine cleavage H-proteins are part of the glycine cleavage system (GCS) found in bacteria, archea and the mitochondria of eukaryotes. GCS is a multienzyme complex consisting of 4 different components (P-, H-, T- and...; Region: GCS_H; cd06848 114615013914 lipoyl attachment site [posttranslational modification]; other site 114615013915 glycine dehydrogenase; Provisional; Region: PRK05367 114615013916 Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613 114615013917 tetramer interface [polypeptide binding]; other site 114615013918 pyridoxal 5'-phosphate binding site [chemical binding]; other site 114615013919 catalytic residue [active] 114615013920 Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613 114615013921 tetramer interface [polypeptide binding]; other site 114615013922 pyridoxal 5'-phosphate binding site [chemical binding]; other site 114615013923 catalytic residue [active] 114615013924 recombinase A; Provisional; Region: recA; PRK09354 114615013925 RecA is a bacterial enzyme which has roles in homologous recombination, DNA repair, and the induction of the SOS response. RecA couples ATP hydrolysis to DNA strand exchange; Region: recA; cd00983 114615013926 hexamer interface [polypeptide binding]; other site 114615013927 Walker A motif; other site 114615013928 ATP binding site [chemical binding]; other site 114615013929 Walker B motif; other site 114615013930 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 114615013931 CoenzymeA binding site [chemical binding]; other site 114615013932 subunit interaction site [polypeptide binding]; other site 114615013933 PHB binding site; other site 114615013934 PilZ domain; Region: PilZ; pfam07238 114615013935 Caspase domain; Region: Peptidase_C14; pfam00656 114615013936 active site 114615013937 substrate pocket [chemical binding]; other site 114615013938 proteolytic cleavage site; other site 114615013939 dimer interface [polypeptide binding]; other site 114615013940 Response regulator containing a CheY-like receiver domain and an HD-GYP domain [Transcription / Signal transduction mechanisms]; Region: COG3437 114615013941 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 114615013942 Zn2+ binding site [ion binding]; other site 114615013943 Mg2+ binding site [ion binding]; other site 114615013944 Acetyltransferase (GNAT) domain; Region: Acetyltransf_6; pfam13480 114615013945 Predicted dithiol-disulfide isomerase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: FrnE; COG2761 114615013946 DsbA family, FrnE subfamily; FrnE is a DsbA-like protein containing a CXXC motif. It is presumed to be a thiol oxidoreductase involved in polyketide biosynthesis, specifically in the production of the aromatic antibiotics frenolicin and nanaomycins; Region: DsbA_FrnE; cd03024 114615013947 catalytic residues [active] 114615013948 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 114615013949 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 114615013950 non-specific DNA binding site [nucleotide binding]; other site 114615013951 salt bridge; other site 114615013952 sequence-specific DNA binding site [nucleotide binding]; other site 114615013953 3-deoxy-D-arabino-heptulosonate 7-phosphate (DAHP) synthase [Amino acid transport and metabolism]; Region: AroG; cl17260 114615013954 Methyltransferase domain; Region: Methyltransf_23; pfam13489 114615013955 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 114615013956 S-adenosylmethionine binding site [chemical binding]; other site 114615013957 SET (Su(var)3-9, Enhancer-of-zeste, Trithorax) domain; Region: SET; smart00317 114615013958 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 114615013959 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 114615013960 WHG domain; Region: WHG; pfam13305 114615013961 Lignostilbene-alpha,beta-dioxygenase and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3670 114615013962 Retinal pigment epithelial membrane protein; Region: RPE65; pfam03055 114615013963 Intracellular septation protein A; Region: IspA; cl01098 114615013964 Protein of unknown function (DUF429); Region: DUF429; pfam04250 114615013965 YdeM is a Bacillus subtilis protein that belongs to a family of prokaryotic proteins of unkown function. YdeM has sequence similarity to the hot-dog fold of (R)-specific enoyl-CoA hydratase. Other enzymes with this fold include the peroxisomal...; Region: YdeM; cd03454 114615013966 putative active site [active] 114615013967 putative catalytic site [active] 114615013968 fumarate hydratase; Provisional; Region: PRK15389 114615013969 Fumarate hydratase (Fumerase); Region: Fumerase; pfam05681 114615013970 Fumarase C-terminus; Region: Fumerase_C; pfam05683 114615013971 GST_N family, Class Sigma_like; composed of GSTs belonging to class Sigma and similar proteins, including GSTs from class Mu, Pi and Alpha. GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of...; Region: GST_N_Sigma_like; cd03039 114615013972 glutathione s-transferase; Provisional; Region: PTZ00057 114615013973 GSH binding site (G-site) [chemical binding]; other site 114615013974 C-terminal domain interface [polypeptide binding]; other site 114615013975 dimer interface [polypeptide binding]; other site 114615013976 C-terminal, alpha helical domain of Class Sigma-like Glutathione S-transferases; Region: GST_C_Sigma_like; cd03192 114615013977 dimer interface [polypeptide binding]; other site 114615013978 N-terminal domain interface [polypeptide binding]; other site 114615013979 substrate binding pocket (H-site) [chemical binding]; other site 114615013980 Tim44-like domain; Region: Tim44; pfam04280 114615013981 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 114615013982 PAS domain; Region: PAS_9; pfam13426 114615013983 putative active site [active] 114615013984 heme pocket [chemical binding]; other site 114615013985 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 114615013986 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 114615013987 dimer interface [polypeptide binding]; other site 114615013988 phosphorylation site [posttranslational modification] 114615013989 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 114615013990 ATP binding site [chemical binding]; other site 114615013991 Mg2+ binding site [ion binding]; other site 114615013992 G-X-G motif; other site 114615013993 Response regulator receiver domain; Region: Response_reg; pfam00072 114615013994 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 114615013995 active site 114615013996 phosphorylation site [posttranslational modification] 114615013997 intermolecular recognition site; other site 114615013998 dimerization interface [polypeptide binding]; other site 114615013999 flagellar biosynthesis protein FlhB; Reviewed; Region: flhB; PRK05702 114615014000 Uncharacterized homolog of the cytoplasmic domain of flagellar protein FhlB [Function unknown]; Region: COG2257 114615014001 flagellar biosynthesis protein FliR; Reviewed; Region: fliR; PRK05701 114615014002 flagellar biosynthesis protein FliQ; Reviewed; Region: fliQ; PRK06010 114615014003 flagellar hook-basal body protein FliE; Reviewed; Region: fliE; PRK00732 114615014004 flagellar basal body rod protein FlgC; Reviewed; Region: flgC; PRK05681 114615014005 Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460 114615014006 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 114615014007 flagellar basal body rod protein FlgB; Reviewed; Region: flgB; PRK06004 114615014008 flagellar basal body rod protein FlgB; Reviewed; Region: flgB; PRK07182 114615014009 flagellar biosynthesis protein FliP; Reviewed; Region: fliP; PRK05699 114615014010 Peptidase S46; Region: Peptidase_S46; pfam10459 114615014011 Uncharacterized conserved protein [Function unknown]; Region: COG3334 114615014012 flagellar motor switch protein FliM; Reviewed; Region: fliM; PRK12795 114615014013 Surface presentation of antigens (SPOA); Region: SpoA; pfam01052 114615014014 flagellar basal body-associated protein FliL; Reviewed; Region: fliL; PRK12785 114615014015 flagellar basal body rod protein FlgF; Reviewed; Region: flgF; PRK12689 114615014016 flagellar basal-body rod protein FlgF; Region: flgF; TIGR02490 114615014017 flagellar basal body rod protein FlgG; Reviewed; Region: flgG; PRK12691 114615014018 Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460 114615014019 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 114615014020 flagellar basal body P-ring biosynthesis protein FlgA; Reviewed; Region: flgA; PRK12786 114615014021 SAF domains of the flagella basal body P-ring formation protein FlgA and the flp pilus assembly CpaB; Region: SAF_CpaB_FlgA_like; cd11614 114615014022 Flagellar basal body L-ring protein [Cell motility and secretion]; Region: FlgH; COG2063 114615014023 flagellar basal body L-ring protein; Reviewed; Region: flgH; PRK00249 114615014024 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; cl11421 114615014025 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 114615014026 aldehyde reductase, extended (e) SDRs; Region: AR_SDR_e; cd05227 114615014027 NADP binding site [chemical binding]; other site 114615014028 putative substrate binding site [chemical binding]; other site 114615014029 active site 114615014030 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 114615014031 PAS fold; Region: PAS_3; pfam08447 114615014032 putative active site [active] 114615014033 heme pocket [chemical binding]; other site 114615014034 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920 114615014035 HWE histidine kinase; Region: HWE_HK; pfam07536 114615014036 RNA polymerase-binding protein DksA; Region: dksA; TIGR02420 114615014037 biliverdin IX beta reductase (BVR-B, aka flavin reductase)-like proteins; atypical (a) SDRs; Region: BVR-B_like_SDR_a; cd05244 114615014038 NADH(P)-binding; Region: NAD_binding_10; pfam13460 114615014039 NAD binding site [chemical binding]; other site 114615014040 putative active site [active] 114615014041 substrate binding site [chemical binding]; other site 114615014042 Predicted transcriptional regulators [Transcription]; Region: COG1733 114615014043 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 114615014044 dimerization interface [polypeptide binding]; other site 114615014045 putative DNA binding site [nucleotide binding]; other site 114615014046 putative Zn2+ binding site [ion binding]; other site 114615014047 flagellar assembly regulator FliX; Reviewed; Region: fliX; PRK12787 114615014048 flagellar basal body P-ring protein; Provisional; Region: flgI; PRK05303 114615014049 flagellar basal body P-ring protein; Reviewed; Region: flgI; cl14622 114615014050 chemotactic signal-response protein CheL; Provisional; Region: PRK12790 114615014051 flagellar biosynthesis regulatory protein FlaF; Reviewed; Region: flaF; PRK12794 114615014052 flagellin; Reviewed; Region: PRK12688 114615014053 flagellin; Reviewed; Region: PRK12688 114615014054 flagellin; Reviewed; Region: PRK12688 114615014055 flagellar biosynthesis repressor FlbT; Reviewed; Region: flbT; PRK12791 114615014056 flagellin; Reviewed; Region: PRK12688 114615014057 flagellin; Reviewed; Region: PRK12688 114615014058 tyrosine decarboxylase; Region: PLN02880 114615014059 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 114615014060 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 114615014061 catalytic residue [active] 114615014062 Glutathione synthase/Ribosomal protein S6 modification enzyme (glutaminyl transferase) [Coenzyme metabolism / Translation, ribosomal structure and biogenesis]; Region: RimK; COG0189 114615014063 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 114615014064 flagellar hook-associated protein FlgL; Validated; Region: flgL; PRK07701 114615014065 flagellin; Provisional; Region: PRK14708 114615014066 flagellar hook-associated protein FlgL; Validated; Region: flgL; PRK06008 114615014067 flagellar hook-associated protein FlgK; Region: flgK_ends; TIGR02492 114615014068 Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460 114615014069 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 114615014070 flagellar hook-basal body protein; Region: FlgEFG_subfam; TIGR03506 114615014071 Flagellar basal body protein FlaE; Region: FlaE; pfam07559 114615014072 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 114615014073 methionine sulfoxide reductase B; Provisional; Region: PRK00222 114615014074 SelR domain; Region: SelR; pfam01641 114615014075 putative aminophosphonate oxidoreductase; Region: Phn_aa_oxid; TIGR03329 114615014076 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 114615014077 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 114615014078 catalytic core [active] 114615014079 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 114615014080 Ligand Binding Site [chemical binding]; other site 114615014081 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3666 114615014082 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 114615014083 Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751 114615014084 YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259 114615014085 putative active site [active] 114615014086 YciF bacterial stress response protein, ferritin-like iron-binding domain; Region: YciF; cd07909 114615014087 dimerization interface [polypeptide binding]; other site 114615014088 metal binding site [ion binding]; metal-binding site 114615014089 Predicted integral membrane protein [Function unknown]; Region: COG0392 114615014090 SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cl01053 114615014091 active site 114615014092 oxyanion hole [active] 114615014093 Uncharacterized protein conserved in bacteria (DUF2147); Region: DUF2147; pfam09917 114615014094 Thioredoxin reductase [Posttranslational modification, protein turnover, chaperones]; Region: TrxB; COG0492 114615014095 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 114615014096 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 114615014097 active site 114615014098 Ferredoxin [Energy production and conversion]; Region: Fdx; COG0633 114615014099 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 114615014100 catalytic loop [active] 114615014101 iron binding site [ion binding]; other site 114615014102 ABC-type transport system involved in resistance to organic solvents, periplasmic component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2C; COG1463 114615014103 mce related protein; Region: MCE; pfam02470 114615014104 ABC-type transport system involved in resistance to organic solvents, ATPase component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2A; COG1127 114615014105 ATP-binding cassette transport system involved in resistant to organic solvents; Region: ABC_Org_Solvent_Resistant; cd03261 114615014106 Walker A/P-loop; other site 114615014107 ATP binding site [chemical binding]; other site 114615014108 Q-loop/lid; other site 114615014109 ABC transporter signature motif; other site 114615014110 Walker B; other site 114615014111 D-loop; other site 114615014112 H-loop/switch region; other site 114615014113 ABC-type transport system involved in resistance to organic solvents, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2B; COG0767 114615014114 Permease; Region: Permease; pfam02405 114615014115 L-Ala-D/L-Glu epimerase; Provisional; Region: PRK15129 114615014116 L-Ala-D/L-Glu epimerase catalyzes the epimerization of L-Ala-D/L-Glu and other dipeptides. The genomic context and the substrate specificity of characterized members of this family from E.coli and B.subtilis indicates a possible role in the metabolism of...; Region: L-Ala-DL-Glu_epimerase; cd03319 114615014117 active site 114615014118 MFS_1 like family; Region: MFS_1_like; pfam12832 114615014119 putative 3-phenylpropionic acid transporter; Provisional; Region: PRK11128 114615014120 Caspase domain; Region: Peptidase_C14; pfam00656 114615014121 substrate pocket [chemical binding]; other site 114615014122 active site 114615014123 proteolytic cleavage site; other site 114615014124 dimer interface [polypeptide binding]; other site 114615014125 serine racemase; Region: PLN02970 114615014126 Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562 114615014127 tetramer interface [polypeptide binding]; other site 114615014128 pyridoxal 5'-phosphate binding site [chemical binding]; other site 114615014129 catalytic residue [active] 114615014130 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 114615014131 Escherichia coli YbbF/LpxH and related proteins, metallophosphatase domain; Region: MPP_YbbF-LpxH; cd07398 114615014132 putative active site [active] 114615014133 putative metal binding site [ion binding]; other site 114615014134 pyruvate kinase; Provisional; Region: PRK06247 114615014135 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl17342 114615014136 domain interfaces; other site 114615014137 active site 114615014138 Isocitrate/isopropylmalate dehydrogenase [Amino acid transport and metabolism]; Region: LeuB; COG0473 114615014139 tartrate dehydrogenase; Region: TTC; TIGR02089 114615014140 DNA-binding transcriptional regulator HcaR; Provisional; Region: PRK09906 114615014141 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 114615014142 The C-terminal substrate binding domain of LysR-type transcriptional regulators involved in the catabolism of aromatic compounds and that of other related regulators, contains type 2 periplasmic binding fold; Region: PBP2_LTTR_aromatics_like; cd08414 114615014143 dimerization interface [polypeptide binding]; other site 114615014144 substrate binding pocket [chemical binding]; other site 114615014145 glycogen debranching enzyme GlgX; Region: glgX_debranch; TIGR02100 114615014146 N-terminal Early set domain associated with the catalytic domain of Glycogen debranching enzyme and bacterial isoamylase (also called glycogen 6-glucanohydrolase); Region: E_set_GDE_Isoamylase_N; cd02856 114615014147 Alpha amylase catalytic domain found in glycogen debranching enzymes; Region: AmyAc_Glg_debranch; cd11326 114615014148 active site 114615014149 catalytic site [active] 114615014150 Immunoglobulin domain; Region: Ig; cl11960 114615014151 Protein of unknown function (DUF3606); Region: DUF3606; pfam12244 114615014152 Protein of unknown function (DUF3551); Region: DUF3551; pfam12071 114615014153 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 114615014154 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 114615014155 ATP binding site [chemical binding]; other site 114615014156 Mg2+ binding site [ion binding]; other site 114615014157 G-X-G motif; other site 114615014158 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 114615014159 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 114615014160 active site 114615014161 phosphorylation site [posttranslational modification] 114615014162 intermolecular recognition site; other site 114615014163 dimerization interface [polypeptide binding]; other site 114615014164 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 114615014165 DNA binding site [nucleotide binding] 114615014166 Predicted membrane protein [Function unknown]; Region: COG3212 114615014167 Peptidase propeptide and YPEB domain; Region: PepSY; pfam03413 114615014168 Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane channels that selectively transport water, small neutral molecules, and ions out of and between cells. The channel proteins share a common fold: the N-terminal...; Region: MIP; cl00200 114615014169 Asn-Pro-Ala signature motifs; other site 114615014170 Low molecular weight phosphatase family; Region: LMWPc; cd00115 114615014171 Protein-tyrosine-phosphatase [Signal transduction mechanisms]; Region: Wzb; COG0394 114615014172 active site 114615014173 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 114615014174 putative DNA binding site [nucleotide binding]; other site 114615014175 dimerization interface [polypeptide binding]; other site 114615014176 putative Zn2+ binding site [ion binding]; other site 114615014177 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 114615014178 dimerization interface [polypeptide binding]; other site 114615014179 putative DNA binding site [nucleotide binding]; other site 114615014180 putative Zn2+ binding site [ion binding]; other site 114615014181 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738 114615014182 Major Facilitator Superfamily; Region: MFS_1; pfam07690 114615014183 Predicted signal transduction protein containing sensor and EAL domains [Signal transduction mechanisms]; Region: COG4943 114615014184 CSS motif domain associated with EAL; Region: CSS-motif; pfam12792 114615014185 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 114615014186 CHRD domain; Region: CHRD; pfam07452 114615014187 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 114615014188 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 114615014189 Transcriptional regulators [Transcription]; Region: GntR; COG1802 114615014190 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 114615014191 DNA-binding site [nucleotide binding]; DNA binding site 114615014192 FCD domain; Region: FCD; pfam07729 114615014193 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 114615014194 active site 114615014195 metal binding site [ion binding]; metal-binding site 114615014196 3,4-dihydroxyphenylacetate 2,3-dioxygenase; Region: HpaD; TIGR02295 114615014197 C-terminal, catalytic, domain of BphC5 (2,3-dihydroxybiphenyl 1,2-dioxygenase) from Bacterium Rhodococcus rhodochrous K37 and similar proteins; Region: BphC5-RK37_C_like; cd07239 114615014198 putative active site [active] 114615014199 Mn binding site [ion binding]; other site 114615014200 putative oligomer interface [polypeptide binding]; other site 114615014201 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 114615014202 3-(3-hydroxyphenyl)propionate hydroxylase; Validated; Region: mhpA; PRK06183 114615014203 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 114615014204 D-galactonate transporter; Region: 2A0114; TIGR00893 114615014205 putative substrate translocation pore; other site 114615014206 2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179 114615014207 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557 114615014208 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3666 114615014209 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 114615014210 Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751 114615014211 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 114615014212 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 114615014213 putative substrate translocation pore; other site 114615014214 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 114615014215 efflux pump membrane protein (multidrug resistance protein A); Region: 8a0101; TIGR00998 114615014216 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 114615014217 HlyD family secretion protein; Region: HlyD_3; pfam13437 114615014218 Protein of unknown function (DUF1275); Region: DUF1275; pfam06912 114615014219 Domain of unknown function (DUF4104); Region: DUF4104; pfam13372 114615014220 Predicted membrane protein [Function unknown]; Region: COG2259 114615014221 Predicted metal-dependent hydrolase with the TIM-barrel fold [General function prediction only]; Region: COG1574 114615014222 YtcJ_like metal dependent amidohydrolases. YtcJ is a Bacillus subtilis ORF of unknown function. The Arabidopsis homolog LAF3 has been identified as a factor required for photochrome A signalling; Region: YtcJ_like; cd01300 114615014223 active site 114615014224 Protein of unknown function (DUF1427); Region: DUF1427; pfam07235 114615014225 Isochorismatase family; Region: Isochorismatase; pfam00857 114615014226 YcaC related amidohydrolases; E.coli YcaC is an homooctameric hydrolase with unknown specificity. Despite its weak sequence similarity, it is structurally related to other amidohydrolases and shares conserved active site residues with them; Region: YcaC_related; cd01012 114615014227 catalytic triad [active] 114615014228 dimer interface [polypeptide binding]; other site 114615014229 conserved cis-peptide bond; other site 114615014230 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 114615014231 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 114615014232 Arabinose-binding domain of AraC transcription regulator, N-term; Region: Arabinose_bd; pfam12625 114615014233 Enolase-superfamily, characterized by the presence of an enolate anion intermediate which is generated by abstraction of the alpha-proton of the carboxylate substrate by an active site residue and is stabilized by coordination to the essential Mg2+ ion; Region: enolase_like; cl17188 114615014234 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 114615014235 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 114615014236 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109 114615014237 4-amino-5-hydroxymethyl-2-methyl-pyrimidine phosphate kinase (HMPP-kinase) catalyzes two consecutive phosphorylation steps in the thiamine phosphate biosynthesis pathway, leading to the synthesis of vitamin B1. The first step is the phosphorylation of...; Region: HMPP_kinase; cd01169 114615014238 dimer interface [polypeptide binding]; other site 114615014239 substrate binding site [chemical binding]; other site 114615014240 ATP binding site [chemical binding]; other site 114615014241 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 114615014242 AsnC family; Region: AsnC_trans_reg; pfam01037 114615014243 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 114615014244 CHASE domain; Region: CHASE; pfam03924 114615014245 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 114615014246 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 114615014247 metal binding site [ion binding]; metal-binding site 114615014248 active site 114615014249 I-site; other site 114615014250 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 114615014251 Periplasmic binding protein; Region: Peripla_BP_6; pfam13458 114615014252 Type I periplasmic binding domain of uncharacterized extracellular ligand-binding proteins; Region: PBP1_STKc_like; cd06326 114615014253 putative ligand binding site [chemical binding]; other site 114615014254 Cytochrome c; Region: Cytochrom_C; cl11414 114615014255 Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010 114615014256 Cytochrome c; Region: Cytochrom_C; pfam00034 114615014257 Cytochrome C' Region: Cytochrom_C_2; pfam01322 114615014258 Aerobic-type carbon monoxide dehydrogenase, large subunit CoxL/CutL homologs [Energy production and conversion]; Region: CoxL; COG1529 114615014259 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; smart01008 114615014260 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 114615014261 Reeler-like domain of YcnI and similar proteins; Region: YcnI_like; cd08545 114615014262 Protein of unknown function (DUF461); Region: DUF461; pfam04314 114615014263 TonB-dependent siderophore receptor; Region: TonB-siderophor; TIGR01783 114615014264 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 114615014265 N-terminal plug; other site 114615014266 ligand-binding site [chemical binding]; other site 114615014267 Uncharacterized membrane protein, putative virulence factor [General function prediction only]; Region: MviN; COG0728 114615014268 MurJ/MviN, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_MurJ_like; cd13123 114615014269 Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WecE; COG0399 114615014270 3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616 114615014271 inhibitor-cofactor binding pocket; inhibition site 114615014272 pyridoxal 5'-phosphate binding site [chemical binding]; other site 114615014273 catalytic residue [active] 114615014274 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 114615014275 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 114615014276 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 114615014277 Protein of unknown function (DUF1223); Region: DUF1223; pfam06764 114615014278 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 114615014279 binding surface 114615014280 TPR motif; other site 114615014281 Predicted O-linked N-acetylglucosamine transferase, SPINDLY family [Posttranslational modification, protein turnover, chaperones]; Region: Spy; COG3914 114615014282 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 114615014283 binding surface 114615014284 TPR motif; other site 114615014285 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 114615014286 binding surface 114615014287 TPR motif; other site 114615014288 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 114615014289 binding surface 114615014290 Tetratricopeptide repeat; Region: TPR_16; pfam13432 114615014291 TPR motif; other site 114615014292 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 114615014293 binding surface 114615014294 TPR repeat; Region: TPR_11; pfam13414 114615014295 TPR motif; other site 114615014296 TPR repeat; Region: TPR_11; pfam13414 114615014297 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 114615014298 binding surface 114615014299 TPR motif; other site 114615014300 TPR repeat; Region: TPR_11; pfam13414 114615014301 mannose-1-phosphate guanylyltransferase/mannose-6-phosphate isomerase; Region: GMP_PMI; TIGR01479 114615014302 GDP-M1P_Guanylyltransferase catalyzes the formation of GDP-Mannose; Region: GDP-M1P_Guanylyltransferase; cd02509 114615014303 Substrate binding site; other site 114615014304 Cupin domain; Region: Cupin_2; cl17218 114615014305 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 114615014306 UDP glucuronic acid epimerase, extended (e) SDRs; Region: UDP_GE_SDE_e; cd05253 114615014307 putative NAD(P) binding site [chemical binding]; other site 114615014308 active site 114615014309 putative substrate binding site [chemical binding]; other site 114615014310 UDP-N-acetyl-D-mannosaminuronate dehydrogenase [Cell envelope biogenesis, outer membrane]; Region: WecC; COG0677 114615014311 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210 114615014312 UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984 114615014313 UDP binding domain; Region: UDPG_MGDP_dh_C; smart00984 114615014314 Uncharacterized protein family (UPF0104); Region: UPF0104; pfam03706 114615014315 exosortase A system-associated amidotransferase 1; Region: eps_aminotran_1; TIGR03108 114615014316 Glutamine amidotransferases class-II (GATase) asparagine synthase_B type. Asparagine synthetase B catalyses the ATP-dependent conversion of aspartate to asparagine. This enzyme is a homodimer, with each monomer composed of a glutaminase domain and a...; Region: AsnB; cd00712 114615014317 active site 114615014318 dimer interface [polypeptide binding]; other site 114615014319 The C-terminal domain of Asparagine Synthase B. This domain is always found associated n-terminal amidotransferase domain. Family members that contain this domain catalyse the conversion of aspartate to asparagine. Asparagine synthetase B catalyzes the...; Region: Asn_Synthase_B_C; cd01991 114615014320 Ligand Binding Site [chemical binding]; other site 114615014321 Molecular Tunnel; other site 114615014322 Predicted acyltransferases [Lipid metabolism]; Region: COG1835 114615014323 Predicted acyltransferases [Lipid metabolism]; Region: COG1835 114615014324 Predicted acyltransferases [Lipid metabolism]; Region: COG1835 114615014325 Predicted membrane protein involved in D-alanine export [Cell envelope biogenesis, outer membrane]; Region: DltB; COG1696 114615014326 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 114615014327 active site 114615014328 nucleotide binding site [chemical binding]; other site 114615014329 HIGH motif; other site 114615014330 KMSKS motif; other site 114615014331 RfaE encodes a bifunctional ADP-heptose synthase involved in the biosynthesis of the lipopolysaccharide (LPS) core precursor ADP-L-glycero-D-manno-heptose. LPS plays an important role in maintaining the structural integrity of the bacterial outer...; Region: RfaE_like; cd01172 114615014332 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 114615014333 putative ribose interaction site [chemical binding]; other site 114615014334 putative ADP binding site [chemical binding]; other site 114615014335 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis/translation initiation factor 2B, gamma/epsilon subunits (eIF-2Bgamma/eIF-2Bepsilon) [Cell envelope biogenesis, outer membrane / Translation, ribosomal structure...; Region: GCD1; COG1208 114615014336 NTP_transferases catalyze the transfer of nucleotides onto phosphosugars; Region: NTP_transferase; cd04181 114615014337 active site 114615014338 Substrate binding site; other site 114615014339 Mg++ binding site; other site 114615014340 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 114615014341 extended (e) SDRs; Region: SDR_e; cd08946 114615014342 NAD(P) binding site [chemical binding]; other site 114615014343 active site 114615014344 substrate binding site [chemical binding]; other site 114615014345 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 114615014346 Phosphoheptose isomerase is a member of the SIS (Sugar ISomerase) superfamily. Phosphoheptose isomerase catalyzes the isomerization of sedoheptulose 7-phosphate into D-glycero-D-mannoheptose 7-phosphate. This is the first step of the biosynthesis of...; Region: SIS_GmhA; cd05006 114615014347 dimer interface [polypeptide binding]; other site 114615014348 active site 114615014349 dTDP-D-glucose 4,6-dehydratase [Cell envelope biogenesis, outer membrane]; Region: RfbB; COG1088 114615014350 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 114615014351 NAD(P) binding site [chemical binding]; other site 114615014352 active site 114615014353 Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012 114615014354 TPP-binding site [chemical binding]; other site 114615014355 dimer interface [polypeptide binding]; other site 114615014356 Transketolase, C-terminal subunit [Carbohydrate transport and metabolism]; Region: COG3958 114615014357 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 114615014358 PYR/PP interface [polypeptide binding]; other site 114615014359 dimer interface [polypeptide binding]; other site 114615014360 TPP binding site [chemical binding]; other site 114615014361 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 114615014362 Zn-dependent alcohol dehydrogenases, class III [Energy production and conversion]; Region: AdhC; COG1062 114615014363 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 114615014364 NAD(P) binding site [chemical binding]; other site 114615014365 Phosphotransferase enzyme family; Region: APH; pfam01636 114615014366 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cd05120 114615014367 active site 114615014368 ATP binding site [chemical binding]; other site 114615014369 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270 114615014370 Methyltransferase domain; Region: Methyltransf_31; pfam13847 114615014371 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 114615014372 S-adenosylmethionine binding site [chemical binding]; other site 114615014373 Putative zinc binding domain; Region: Methyltransf_13; pfam08421 114615014374 Methyltransferase domain; Region: Methyltransf_23; pfam13489 114615014375 Methyltransferase domain; Region: Methyltransf_12; pfam08242 114615014376 C-methyltransferase C-terminal domain; Region: Methyltransf_14; pfam08484 114615014377 cupin fold metalloprotein, WbuC family; Region: cupin_WbuC; TIGR04366 114615014378 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 114615014379 classical (c) SDRs; Region: SDR_c; cd05233 114615014380 NAD(P) binding site [chemical binding]; other site 114615014381 active site 114615014382 Putative zinc binding domain; Region: Methyltransf_13; pfam08421 114615014383 Methyltransferase domain; Region: Methyltransf_23; pfam13489 114615014384 C-methyltransferase C-terminal domain; Region: Methyltransf_14; pfam08484 114615014385 ABC-type polysaccharide/polyol phosphate export systems, permease component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagG; COG1682 114615014386 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 114615014387 ABC-type polysaccharide/polyol phosphate transport system, ATPase component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagH; COG1134 114615014388 ATP-binding cassette component of polysaccharide transport system; Region: ABC_KpsT_Wzt; cd03220 114615014389 Walker A/P-loop; other site 114615014390 ATP binding site [chemical binding]; other site 114615014391 Q-loop/lid; other site 114615014392 ABC transporter signature motif; other site 114615014393 Walker B; other site 114615014394 D-loop; other site 114615014395 H-loop/switch region; other site 114615014396 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 114615014397 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 114615014398 active site 114615014399 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 114615014400 binding surface 114615014401 TPR motif; other site 114615014402 WcxM-like, Left-handed parallel beta-Helix (LbH) N-terminal domain: This group is composed of Xanthomonas campestris WcxM and proteins with similarity to the WcxM N-terminal domain. WcxM is thought to be bifunctional, catalyzing both the isomerization...; Region: LbH_WxcM_N_like; cd03358 114615014403 putative trimer interface [polypeptide binding]; other site 114615014404 putative active site [active] 114615014405 putative substrate binding site [chemical binding]; other site 114615014406 putative CoA binding site [chemical binding]; other site 114615014407 Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WecE; COG0399 114615014408 3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616 114615014409 inhibitor-cofactor binding pocket; inhibition site 114615014410 pyridoxal 5'-phosphate binding site [chemical binding]; other site 114615014411 catalytic residue [active] 114615014412 Stf0 sulphotransferase; Region: Sulphotransf; cl01835 114615014413 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 114615014414 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 114615014415 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 114615014416 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 114615014417 NAD(P) binding site [chemical binding]; other site 114615014418 active site 114615014419 Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WecE; COG0399 114615014420 3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616 114615014421 inhibitor-cofactor binding pocket; inhibition site 114615014422 pyridoxal 5'-phosphate binding site [chemical binding]; other site 114615014423 catalytic residue [active] 114615014424 sulfate adenylyltransferase, small subunit; Region: CysD; TIGR02039 114615014425 This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713 114615014426 Active Sites [active] 114615014427 bifunctional sulfate adenylyltransferase subunit 1/adenylylsulfate kinase protein; Provisional; Region: PRK05506 114615014428 CysN, together with protein CysD, forms the ATP sulfurylase (ATPS) complex; Region: CysN_ATPS; cd04166 114615014429 CysD dimerization site [polypeptide binding]; other site 114615014430 G1 box; other site 114615014431 putative GEF interaction site [polypeptide binding]; other site 114615014432 GTP/Mg2+ binding site [chemical binding]; other site 114615014433 Switch I region; other site 114615014434 G2 box; other site 114615014435 G3 box; other site 114615014436 Switch II region; other site 114615014437 G4 box; other site 114615014438 G5 box; other site 114615014439 CysN_NodQ_II: This subfamily represents the domain II of the large subunit of ATP sulfurylase (ATPS): CysN or the N-terminal portion of NodQ, found mainly in proteobacteria and homologous to the domain II of EF-Tu. Escherichia coli ATPS consists of CysN...; Region: CysN_NodQ_II; cd03695 114615014440 TCysN_NoDQ_II: This subfamily represents the domain II of the large subunit of ATP sulfurylase (ATPS): CysN or the N-terminal portion of NodQ, found mainly in proteobacteria and homologous to the domain II of EF-Tu. Escherichia coli ATPS consists of CysN...; Region: CysN_NoDQ_III; cd04095 114615014441 Adenosine 5'-phosphosulfate kinase (APSK) catalyzes the phosphorylation of adenosine 5'-phosphosulfate to form 3'-phosphoadenosine 5'-phosphosulfate (PAPS). The end-product PAPS is a biologically "activated" sulfate form...; Region: APSK; cd02027 114615014442 ligand-binding site [chemical binding]; other site 114615014443 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 114615014444 S-adenosylmethionine binding site [chemical binding]; other site 114615014445 Catalytic NodB homology domain of the carbohydrate esterase 4 superfamily; Region: CE4_SF; cl15692 114615014446 undecaprenyl phosphate 4-deoxy-4-formamido-L-arabinose transferase; Provisional; Region: PRK10714 114615014447 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 114615014448 This family is most closely related to the GT1 family of glycosyltransferases. cap1E in Streptococcus pneumoniae is required for the synthesis of type 1 capsular polysaccharides; Region: GT1_cap1E_like; cd03808 114615014449 putative ADP-binding pocket [chemical binding]; other site 114615014450 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 114615014451 UDP-N-acetylmuramyl pentapeptide phosphotransferase/UDP-N- acetylglucosamine-1-phosphate transferase [Cell envelope biogenesis, outer membrane]; Region: Rfe; COG0472 114615014452 The members of this subfamily catalyze the formation of a phosphodiester bond between a membrane-associated undecaprenyl-phosphate (Und-P) molecule and N-acetylhexosamine 1-phosphate, which is usually donated by a soluble UDP-N-acetylhexosamine precursor; Region: GT_WbpL_WbcO_like; cd06854 114615014453 Mg++ binding site [ion binding]; other site 114615014454 putative catalytic motif [active] 114615014455 putative substrate binding site [chemical binding]; other site 114615014456 Predicted nucleoside-diphosphate sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG1086 114615014457 UDP-Glcnac (UDP-linked N-acetylglucosamine) inverting 4,6-dehydratase, extended (e) SDRs; Region: UDP_invert_4-6DH_SDR_e; cd05237 114615014458 NAD(P) binding site [chemical binding]; other site 114615014459 homodimer interface [polypeptide binding]; other site 114615014460 substrate binding site [chemical binding]; other site 114615014461 active site 114615014462 Lipid A core - O-antigen ligase and related enzymes [Cell envelope biogenesis, outer membrane]; Region: RfaL; COG3307 114615014463 O-Antigen ligase; Region: Wzy_C; pfam04932 114615014464 ADP-heptose synthase, bifunctional sugar kinase/adenylyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaE; COG2870 114615014465 RfaE encodes a bifunctional ADP-heptose synthase involved in the biosynthesis of the lipopolysaccharide (LPS) core precursor ADP-L-glycero-D-manno-heptose. LPS plays an important role in maintaining the structural integrity of the bacterial outer...; Region: RfaE_like; cd01172 114615014466 putative ribose interaction site [chemical binding]; other site 114615014467 putative ADP binding site [chemical binding]; other site 114615014468 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 114615014469 active site 114615014470 HIGH motif; other site 114615014471 nucleotide binding site [chemical binding]; other site 114615014472 ADP-L-glycero-D-mannoheptose 6-epimerase (GME), extended (e) SDRs; Region: ADP_GME_SDR_e; cd05248 114615014473 ADP-L-glycero-D-manno-heptose-6-epimerase; Region: heptose_epim; TIGR02197 114615014474 NADP binding site [chemical binding]; other site 114615014475 homopentamer interface [polypeptide binding]; other site 114615014476 substrate binding site [chemical binding]; other site 114615014477 active site 114615014478 Lipopolysaccharide heptosyltransferase is involved in the biosynthesis of lipooligosaccharide (LOS). Lipopolysaccharide (LPS) is a major component of the outer membrane of gram-negative bacteria. LPS heptosyltransferase transfers heptose molecules from...; Region: GT1_LPS_heptosyltransferase; cd03789 114615014479 ADP-heptose:LPS heptosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaF; COG0859 114615014480 putative active site [active] 114615014481 Phosphoheptose isomerase is a member of the SIS (Sugar ISomerase) superfamily. Phosphoheptose isomerase catalyzes the isomerization of sedoheptulose 7-phosphate into D-glycero-D-mannoheptose 7-phosphate. This is the first step of the biosynthesis of...; Region: SIS_GmhA; cd05006 114615014482 dimer interface [polypeptide binding]; other site 114615014483 active site 114615014484 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 114615014485 active site 114615014486 motif I; other site 114615014487 motif II; other site 114615014488 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 114615014489 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 114615014490 UDP-glucose 4-epimerase [Cell envelope biogenesis, outer membrane]; Region: GalE; COG1087 114615014491 UDP-glucose 4 epimerase, subgroup 1, extended (e) SDRs; Region: UDP_G4E_1_SDR_e; cd05247 114615014492 NAD binding site [chemical binding]; other site 114615014493 homodimer interface [polypeptide binding]; other site 114615014494 active site 114615014495 substrate binding site [chemical binding]; other site 114615014496 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 114615014497 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 114615014498 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 114615014499 Walker A/P-loop; other site 114615014500 ATP binding site [chemical binding]; other site 114615014501 Q-loop/lid; other site 114615014502 ABC transporter signature motif; other site 114615014503 Walker B; other site 114615014504 D-loop; other site 114615014505 H-loop/switch region; other site 114615014506 2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179 114615014507 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557 114615014508 RT_G2_intron: Reverse transcriptases (RTs) with group II intron origin. RT transcribes DNA using RNA as template. Proteins in this subfamily are found in bacterial and mitochondrial group II introns. Their most probable ancestor was a retrotransposable...; Region: RT_G2_intron; cd01651 114615014509 Reverse transcriptase (RNA-dependent DNA polymerase); Region: RVT_1; pfam00078 114615014510 putative active site [active] 114615014511 putative NTP binding site [chemical binding]; other site 114615014512 putative nucleic acid binding site [nucleotide binding]; other site 114615014513 Putative cyclase; Region: Cyclase; pfam04199 114615014514 Putative GTPases (G3E family) [General function prediction only]; Region: COG0523 114615014515 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 114615014516 Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; pfam07683 114615014517 Aspartyl/asparaginyl beta-hydroxylase and related dioxygenases [Posttranslational modification, protein turnover, chaperones]; Region: COG3555 114615014518 PilZ domain; Region: PilZ; pfam07238 114615014519 Flp pilus assembly protein CpaB [Intracellular trafficking and secretion]; Region: CpaB; COG3745 114615014520 SAF domains of the flagella basal body P-ring formation protein FlgA and the flp pilus assembly CpaB; Region: SAF_CpaB_FlgA_like; cd11614 114615014521 Flp pilus assembly protein, secretin CpaC [Intracellular trafficking and secretion]; Region: CpaC; COG4964 114615014522 Pilus formation protein N terminal region; Region: T2SS-T3SS_pil_N; pfam13629 114615014523 Bacterial type II and III secretion system protein; Region: Secretin; pfam00263 114615014524 Type IV pili component [Cell motility and secretion]; Region: COG5461 114615014525 Pilus biogenesis CpaD protein (pilus_cpaD); Region: Pilus_CpaD; pfam09476 114615014526 Flp pilus assembly protein, ATPase CpaE [Intracellular trafficking and secretion]; Region: CpaE; COG4963 114615014527 This protein family consists of proteins similar to the cpaE protein of the Caulobacter pilus assembly and the orf4 protein of Actinobacillus pilus formation gene cluster. The function of these proteins are unkown. The Caulobacter pilus assembly contains...; Region: CpaE_like; cd03111 114615014528 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 114615014529 TPR motif; other site 114615014530 binding surface 114615014531 Tetratricopeptide repeat; Region: TPR_16; pfam13432 114615014532 PilZ domain; Region: PilZ; cl01260 114615014533 phenol 2-monooxygenase; Provisional; Region: PRK08294 114615014534 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 114615014535 FAD-dependent Phenol hydoxylase (PHOX) family, C-terminal TRX-fold domain; composed of proteins similar to PHOX from the aerobic topsoil yeast Trichosporon cutaneum. PHOX is a flavoprotein monooxygenase that catalyzes the hydroxylation of phenol and...; Region: PHOX_C; cd02979 114615014536 dimer interface [polypeptide binding]; other site 114615014537 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 114615014538 MarR family; Region: MarR; pfam01047 114615014539 MarR family; Region: MarR_2; cl17246 114615014540 Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072 114615014541 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738 114615014542 Predicted metal-dependent hydrolases related to alanyl-tRNA synthetase HxxxH domain [General function prediction only]; Region: COG2872 114615014543 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863 114615014544 AAA domain; Region: AAA_33; pfam13671 114615014545 AAA domain; Region: AAA_17; cl17253 114615014546 Phosphoinositide 3-kinase (PI3K)-like family, catalytic domain; The PI3K-like catalytic domain family is part of a larger superfamily that includes the catalytic domains of other kinases such as the typical serine/threonine/tyrosine protein kinases (PKs); Region: PI3Kc_like; cl00119 114615014547 catalytic loop [active] 114615014548 Peptidase propeptide and YPEB domain; Region: PepSY_2; pfam13670 114615014549 Cytochrome b (N-terminus)/b6/petB: Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria; Region: Cytochrome_b_N; cl00859 114615014550 D-alanyl-D-alanine carboxypeptidase; Region: VanY; pfam02557 114615014551 S-adenosyl-L-homocysteine hydrolase; Provisional; Region: PRK05476 114615014552 S-Adenosylhomocysteine Hydrolase, NAD-binding and catalytic domains; Region: SAHH; cd00401 114615014553 homotetramer interface [polypeptide binding]; other site 114615014554 ligand binding site [chemical binding]; other site 114615014555 catalytic site [active] 114615014556 NAD binding site [chemical binding]; other site 114615014557 S-adenosylmethionine synthetase; Validated; Region: PRK05250 114615014558 S-adenosylmethionine synthetase, N-terminal domain; Region: S-AdoMet_synt_N; pfam00438 114615014559 S-adenosylmethionine synthetase, central domain; Region: S-AdoMet_synt_M; pfam02772 114615014560 S-adenosylmethionine synthetase, C-terminal domain; Region: S-AdoMet_synt_C; pfam02773 114615014561 TPR repeat; Region: TPR_11; pfam13414 114615014562 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 114615014563 binding surface 114615014564 TPR motif; other site 114615014565 TPR repeat; Region: TPR_11; pfam13414 114615014566 Uncharacterized protein containing caspase domain [General function prediction only]; Region: COG4249 114615014567 Caspase domain; Region: Peptidase_C14; pfam00656 114615014568 Methyltransferase domain; Region: Methyltransf_23; pfam13489 114615014569 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 114615014570 S-adenosylmethionine binding site [chemical binding]; other site 114615014571 Uncharacterized protein conserved in bacteria (DUF2147); Region: DUF2147; pfam09917 114615014572 GDSL-like Lipase/Acylhydrolase family; Region: Lipase_GDSL_2; pfam13472 114615014573 active site 114615014574 catalytic triad [active] 114615014575 oxyanion hole [active] 114615014576 Predicted acyltransferases [Lipid metabolism]; Region: COG1835 114615014577 Predicted transcriptional regulator [Transcription]; Region: COG3636; cl17681 114615014578 CIMS - Cobalamine-independent methonine synthase, or MetE, C-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_C_terminal_like; cd03311 114615014579 substrate binding site [chemical binding]; other site 114615014580 THF binding site; other site 114615014581 zinc-binding site [ion binding]; other site 114615014582 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410 114615014583 ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224 114615014584 Walker A/P-loop; other site 114615014585 ATP binding site [chemical binding]; other site 114615014586 Q-loop/lid; other site 114615014587 ABC transporter signature motif; other site 114615014588 Walker B; other site 114615014589 D-loop; other site 114615014590 H-loop/switch region; other site 114615014591 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411 114615014592 ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219 114615014593 Walker A/P-loop; other site 114615014594 ATP binding site [chemical binding]; other site 114615014595 Q-loop/lid; other site 114615014596 ABC transporter signature motif; other site 114615014597 Walker B; other site 114615014598 D-loop; other site 114615014599 H-loop/switch region; other site 114615014600 ABC-type branched-chain amino acid transport system, permease component [Amino acid transport and metabolism]; Region: LivM; COG4177 114615014601 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 114615014602 TM-ABC transporter signature motif; other site 114615014603 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 114615014604 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 114615014605 TM-ABC transporter signature motif; other site 114615014606 Periplasmic binding protein; Region: Peripla_BP_6; pfam13458 114615014607 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 114615014608 formyltetrahydrofolate deformylase; Reviewed; Region: purU; PRK06027 114615014609 N-terminal ACT domain of formyltetrahydrofolate deformylase (F4HF-DF; formyltetrahydrofolate hydrolase); Region: ACT_F4HF-DF; cd04875 114615014610 Formyltetrahydrofolate deformylase (Formyl-FH4 hydrolase), C-terminal hydrolase domain; Region: FMT_core_Formyl-FH4-Hydrolase_C; cd08648 114615014611 putative active site [active] 114615014612 putative substrate binding site [chemical binding]; other site 114615014613 putative cosubstrate binding site; other site 114615014614 catalytic site [active] 114615014615 Uroporphyrinogen-III synthase [Coenzyme metabolism]; Region: HemD; COG1587 114615014616 Uroporphyrinogen-III synthase (HemD) catalyzes the asymmetrical cyclization of tetrapyrrole (linear) to uroporphyrinogen-III, the fourth step in the biosynthesis of heme. This ubiquitous enzyme is present in eukaryotes, bacteria and archaea. Mutations in...; Region: HemD; cd06578 114615014617 active site 114615014618 GDP-4-keto-6-deoxymannose-3, 5-epimerase-4-reductase; Region: PLN02725 114615014619 GDP-fucose synthetase, extended (e) SDRs; Region: GDP_FS_SDR_e; cd05239 114615014620 NADP binding site [chemical binding]; other site 114615014621 active site 114615014622 putative substrate binding site [chemical binding]; other site 114615014623 GDP-D-mannose dehydratase [Cell envelope biogenesis, outer membrane]; Region: Gmd; COG1089 114615014624 GDP-mannose 4,6 dehydratase, extended (e) SDRs; Region: GDP_MD_SDR_e; cd05260 114615014625 NADP-binding site; other site 114615014626 homotetramer interface [polypeptide binding]; other site 114615014627 substrate binding site [chemical binding]; other site 114615014628 homodimer interface [polypeptide binding]; other site 114615014629 active site 114615014630 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 114615014631 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 114615014632 ligand binding site [chemical binding]; other site 114615014633 flexible hinge region; other site 114615014634 Crp-like helix-turn-helix domain; Region: HTH_Crp_2; pfam13545 114615014635 putative switch regulator; other site 114615014636 non-specific DNA interactions [nucleotide binding]; other site 114615014637 DNA binding site [nucleotide binding] 114615014638 sequence specific DNA binding site [nucleotide binding]; other site 114615014639 putative cAMP binding site [chemical binding]; other site 114615014640 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411 114615014641 ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219 114615014642 Walker A/P-loop; other site 114615014643 ATP binding site [chemical binding]; other site 114615014644 Q-loop/lid; other site 114615014645 ABC transporter signature motif; other site 114615014646 Walker B; other site 114615014647 D-loop; other site 114615014648 H-loop/switch region; other site 114615014649 Long-chain acyl-CoA synthetases (AMP-forming) [Lipid metabolism]; Region: FAA1; COG1022 114615014650 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 114615014651 Long-chain fatty acid CoA synthetases and Bubblegum-like very long-chain fatty acid CoA synthetases; Region: VL_LC_FACS_like; cd05907 114615014652 acyl-activating enzyme (AAE) consensus motif; other site 114615014653 putative AMP binding site [chemical binding]; other site 114615014654 putative active site [active] 114615014655 putative CoA binding site [chemical binding]; other site 114615014656 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 114615014657 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 114615014658 TM-ABC transporter signature motif; other site 114615014659 ABC-type branched-chain amino acid transport system, permease component [Amino acid transport and metabolism]; Region: LivM; COG4177 114615014660 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 114615014661 TM-ABC transporter signature motif; other site 114615014662 Periplasmic binding protein; Region: Peripla_BP_6; pfam13458 114615014663 Type I periplasmic ligand-binding domain of uncharacterized ABC (ATPase Binding Cassette)-type active transport systems that are predicted to be involved in transport of amino acids, peptides, or inorganic ions; Region: PBP1_ABC_ligand_binding_like_1; cd06334 114615014664 putative ligand binding site [chemical binding]; other site 114615014665 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410 114615014666 ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224 114615014667 Walker A/P-loop; other site 114615014668 ATP binding site [chemical binding]; other site 114615014669 Q-loop/lid; other site 114615014670 ABC transporter signature motif; other site 114615014671 Walker B; other site 114615014672 D-loop; other site 114615014673 H-loop/switch region; other site 114615014674 phenylacetate-CoA ligase; Region: PA_CoA_ligase; TIGR02155 114615014675 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 114615014676 acyl-activating enzyme (AAE) consensus motif; other site 114615014677 active site 114615014678 AMP binding site [chemical binding]; other site 114615014679 CoA binding site [chemical binding]; other site 114615014680 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 114615014681 CoA-transferase family III; Region: CoA_transf_3; pfam02515 114615014682 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3333 114615014683 Tripartite tricarboxylate transporter TctB family; Region: TctB; pfam07331 114615014684 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3181 114615014685 enoyl-CoA hydratase; Provisional; Region: PRK06144 114615014686 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 114615014687 substrate binding site [chemical binding]; other site 114615014688 oxyanion hole (OAH) forming residues; other site 114615014689 trimer interface [polypeptide binding]; other site 114615014690 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cl15762 114615014691 Alanine-glyoxylate aminotransferase (AGAT) family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to alanine-glyoxylate aminotransferase (AGAT); Region: AGAT_like; cd06451 114615014692 homodimer interface [polypeptide binding]; other site 114615014693 pyridoxal 5'-phosphate binding site [chemical binding]; other site 114615014694 catalytic residue [active] 114615014695 Alanine-glyoxylate aminotransferase (AGAT) family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to alanine-glyoxylate aminotransferase (AGAT); Region: AGAT_like; cd06451 114615014696 homodimer interface [polypeptide binding]; other site 114615014697 pyridoxal 5'-phosphate binding site [chemical binding]; other site 114615014698 catalytic residue [active] 114615014699 Transcriptional regulators [Transcription]; Region: GntR; COG1802 114615014700 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 114615014701 DNA-binding site [nucleotide binding]; DNA binding site 114615014702 FCD domain; Region: FCD; pfam07729 114615014703 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 114615014704 FAD binding domain; Region: FAD_binding_4; pfam01565 114615014705 Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247 114615014706 Domain of unknown function (DUF336); Region: DUF336; cl01249 114615014707 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 114615014708 short chain dehydrogenase; Provisional; Region: PRK07109 114615014709 classical (c) SDR, subgroup 3; Region: SDR_c3; cd05360 114615014710 putative NAD(P) binding site [chemical binding]; other site 114615014711 active site 114615014712 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 114615014713 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 114615014714 active site 114615014715 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 114615014716 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 114615014717 Coenzyme A binding pocket [chemical binding]; other site 114615014718 Predicted membrane protein [Function unknown]; Region: COG2311 114615014719 Protein of unknown function (DUF418); Region: DUF418; pfam04235 114615014720 enoyl-CoA hydratase; Provisional; Region: PRK05995 114615014721 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 114615014722 substrate binding site [chemical binding]; other site 114615014723 oxyanion hole (OAH) forming residues; other site 114615014724 trimer interface [polypeptide binding]; other site 114615014725 PGAP1-like protein; Region: PGAP1; pfam07819 114615014726 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 114615014727 acylglycerophosphoethanolamine acyltransferase; Provisional; Region: PRK06814 114615014728 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 114615014729 putative substrate translocation pore; other site 114615014730 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 114615014731 putative acyl-acceptor binding pocket; other site 114615014732 C-terminal domain of the acyl-acyl carrier protein synthetase (also called 2-acylglycerophosphoethanolamine acyltransferase, Aas); Region: AAS_C; cd05909 114615014733 acyl-activating enzyme (AAE) consensus motif; other site 114615014734 putative AMP binding site [chemical binding]; other site 114615014735 yiaA/B two helix domain; Region: YiaAB; cl01759 114615014736 Anaerobic dehydrogenases, typically selenocysteine-containing [Energy production and conversion]; Region: BisC; COG0243 114615014737 The MopB_3 CD includes a group of related uncharacterized bacterial and archaeal molybdopterin-binding oxidoreductase-like domains with a putative N-terminal iron-sulfur [4Fe-4S] cluster binding site and molybdopterin cofactor binding site. These members...; Region: MopB_3; cd02766 114615014738 putative [4Fe-4S] binding site [ion binding]; other site 114615014739 putative molybdopterin cofactor binding site [chemical binding]; other site 114615014740 The MopB_CT_3 CD includes a group of related uncharacterized bacterial molybdopterin-binding oxidoreductase-like domains with a putative N-terminal iron-sulfur [4Fe-4S] cluster binding site and molybdopterin cofactor binding site. This CD is of the...; Region: MopB_CT_3; cd02786 114615014741 putative molybdopterin cofactor binding site; other site 114615014742 Transcriptional regulators [Transcription]; Region: GntR; COG1802 114615014743 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 114615014744 DNA-binding site [nucleotide binding]; DNA binding site 114615014745 FCD domain; Region: FCD; pfam07729 114615014746 TRAP-type C4-dicarboxylate transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: DctP; COG1638 114615014747 Bacterial extracellular solute-binding protein, family 7; Region: SBP_bac_7; pfam03480 114615014748 TRAP-type C4-dicarboxylate transport system, small permease component [Carbohydrate transport and metabolism]; Region: DctM; COG3090 114615014749 DctM-like transporters; Region: DctM; pfam06808 114615014750 TRAP-type C4-dicarboxylate transport system, large permease component [Carbohydrate transport and metabolism]; Region: DctQ; COG1593 114615014751 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 114615014752 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 114615014753 ligand binding site [chemical binding]; other site 114615014754 flexible hinge region; other site 114615014755 Crp-like helix-turn-helix domain; Region: HTH_Crp_2; pfam13545 114615014756 putative switch regulator; other site 114615014757 non-specific DNA interactions [nucleotide binding]; other site 114615014758 DNA binding site [nucleotide binding] 114615014759 sequence specific DNA binding site [nucleotide binding]; other site 114615014760 putative cAMP binding site [chemical binding]; other site 114615014761 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 114615014762 ligand binding site [chemical binding]; other site 114615014763 flexible hinge region; other site 114615014764 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 114615014765 putative switch regulator; other site 114615014766 non-specific DNA interactions [nucleotide binding]; other site 114615014767 DNA binding site [nucleotide binding] 114615014768 sequence specific DNA binding site [nucleotide binding]; other site 114615014769 putative cAMP binding site [chemical binding]; other site 114615014770 Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010 114615014771 Cytochrome c; Region: Cytochrom_C; pfam00034 114615014772 ABC-type transport system involved in resistance to organic solvents, periplasmic component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2C; COG1463 114615014773 mce related protein; Region: MCE; pfam02470 114615014774 Protein of unknown function (DUF330); Region: DUF330; cl01135 114615014775 ABC-type transport system involved in resistance to organic solvents, ATPase component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2A; COG1127 114615014776 ATP-binding cassette transport system involved in resistant to organic solvents; Region: ABC_Org_Solvent_Resistant; cd03261 114615014777 Walker A/P-loop; other site 114615014778 ATP binding site [chemical binding]; other site 114615014779 Q-loop/lid; other site 114615014780 ABC transporter signature motif; other site 114615014781 Walker B; other site 114615014782 D-loop; other site 114615014783 H-loop/switch region; other site 114615014784 ABC-type transport system involved in resistance to organic solvents, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2B; COG0767 114615014785 Permease; Region: Permease; pfam02405 114615014786 Acyl-CoA synthetase (NDP forming) [Energy production and conversion]; Region: COG1042 114615014787 CoA binding domain; Region: CoA_binding_2; pfam13380 114615014788 Succinyl-CoA ligase like flavodoxin domain; Region: Succ_CoA_lig; pfam13607 114615014789 ATP-grasp domain; Region: ATP-grasp_5; pfam13549 114615014790 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 114615014791 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 114615014792 Coenzyme A binding pocket [chemical binding]; other site 114615014793 Zn-dependent alcohol dehydrogenases [General function prediction only]; Region: AdhP; COG1064 114615014794 Cinnamyl alcohol dehydrogenases (CAD); Region: CAD2; cd08298 114615014795 putative NAD(P) binding site [chemical binding]; other site 114615014796 putative substrate binding site [chemical binding]; other site 114615014797 catalytic Zn binding site [ion binding]; other site 114615014798 structural Zn binding site [ion binding]; other site 114615014799 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2187 114615014800 Uncharacterized protein, probably involved in trehalose biosynthesis [Carbohydrate transport and metabolism]; Region: Ble; COG3281 114615014801 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270 114615014802 substrate binding site [chemical binding]; other site 114615014803 Predicted kinase [General function prediction only]; Region: COG0645 114615014804 Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates...; Region: NK; cl17190 114615014805 active site 114615014806 Poly-beta-hydroxybutyrate polymerase N terminal; Region: PHBC_N; pfam12551 114615014807 poly(R)-hydroxyalkanoic acid synthase, class I; Region: PHA_synth_I; TIGR01838 114615014808 Poly-beta-hydroxybutyrate polymerase (PhaC) N-terminus; Region: PhaC_N; pfam07167 114615014809 FOG: CBS domain [General function prediction only]; Region: COG0517 114615014810 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the BON (bacterial OsmY and nodulation domain) domain. BON is a putative phospholipid-binding domain found in a family of osmotic shock protection...; Region: CBS_pair_BON_assoc; cd04586 114615014811 FOG: CBS domain [General function prediction only]; Region: COG0517 114615014812 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cd02205 114615014813 BON domain; Region: BON; pfam04972 114615014814 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 114615014815 CoA-transferase family III; Region: CoA_transf_3; pfam02515 114615014816 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 114615014817 Coenzyme A binding pocket [chemical binding]; other site 114615014818 hypothetical protein; Region: PHA00649 114615014819 GAF domain; Region: GAF_3; pfam13492 114615014820 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 114615014821 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 114615014822 dimer interface [polypeptide binding]; other site 114615014823 phosphorylation site [posttranslational modification] 114615014824 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 114615014825 ATP binding site [chemical binding]; other site 114615014826 Mg2+ binding site [ion binding]; other site 114615014827 G-X-G motif; other site 114615014828 Response regulator receiver domain; Region: Response_reg; pfam00072 114615014829 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 114615014830 active site 114615014831 phosphorylation site [posttranslational modification] 114615014832 intermolecular recognition site; other site 114615014833 dimerization interface [polypeptide binding]; other site 114615014834 Signal transduction histidine kinase, nitrogen specific [Signal transduction mechanisms]; Region: NtrB; COG3852 114615014835 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 114615014836 putative active site [active] 114615014837 heme pocket [chemical binding]; other site 114615014838 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 114615014839 dimer interface [polypeptide binding]; other site 114615014840 phosphorylation site [posttranslational modification] 114615014841 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 114615014842 ATP binding site [chemical binding]; other site 114615014843 Mg2+ binding site [ion binding]; other site 114615014844 G-X-G motif; other site 114615014845 Response regulator receiver domain; Region: Response_reg; pfam00072 114615014846 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 114615014847 active site 114615014848 phosphorylation site [posttranslational modification] 114615014849 intermolecular recognition site; other site 114615014850 dimerization interface [polypeptide binding]; other site 114615014851 Mn2+ and Fe2+ transporters of the NRAMP family [Inorganic ion transport and metabolism]; Region: MntH; COG1914 114615014852 Natural resistance-associated macrophage protein; Region: Nramp; pfam01566 114615014853 malate dehydrogenase; Provisional; Region: PRK13529 114615014854 Malic enzyme, N-terminal domain; Region: malic; pfam00390 114615014855 NAD(P) binding domain of malic enzyme (ME), subgroup 1; Region: NAD_bind_1_malic_enz; cd05312 114615014856 NAD(P) binding site [chemical binding]; other site 114615014857 Arginase family; Region: Arginase; cd09989 114615014858 agmatinase; Region: agmatinase; TIGR01230 114615014859 active site 114615014860 Mn binding site [ion binding]; other site 114615014861 oligomer interface [polypeptide binding]; other site 114615014862 OpgC protein; Region: OpgC_C; pfam10129 114615014863 Acyltransferase family; Region: Acyl_transf_3; pfam01757 114615014864 Cytochrome c; Region: Cytochrom_C; cl11414 114615014865 Phasin protein; Region: Phasin_2; cl11491 114615014866 Putative protein-S-isoprenylcysteine methyltransferase [Posttranslational modification, protein turnover, chaperones]; Region: STE14; COG2020 114615014867 outer membrane protein assembly complex, YaeT protein; Region: OM_YaeT; TIGR03303 114615014868 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 114615014869 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 114615014870 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 114615014871 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 114615014872 Surface antigen; Region: Bac_surface_Ag; pfam01103 114615014873 GcrA cell cycle regulator; Region: GcrA; cl11564 114615014874 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl17200 114615014875 non-specific DNA binding site [nucleotide binding]; other site 114615014876 salt bridge; other site 114615014877 sequence-specific DNA binding site [nucleotide binding]; other site 114615014878 Predicted transcriptional regulator [Transcription]; Region: COG2932 114615014879 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 114615014880 Catalytic site [active] 114615014881 quinone oxidoreductase, NADPH-dependent; Provisional; Region: PRK10754 114615014882 Quinone oxidoreductase (QOR); Region: QOR2; cd05286 114615014883 NADP binding site [chemical binding]; other site 114615014884 dimer interface [polypeptide binding]; other site 114615014885 Membrane transporters of cations and cationic drugs [Inorganic ion transport and metabolism]; Region: EmrE; COG2076 114615014886 Predicted integral membrane protein [Function unknown]; Region: COG0392 114615014887 PPOX class probable FMN-dependent enzyme, DR_2398 family; Region: PPOX_FMN_DR2398; TIGR04025 114615014888 Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates...; Region: NK; cl17190 114615014889 active site 114615014890 phosphonate metabolism protein PhnM; Provisional; Region: PRK15446 114615014891 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 114615014892 active site 114615014893 ABC-type phosphonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: PhnL; COG4778 114615014894 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 114615014895 Walker A/P-loop; other site 114615014896 ATP binding site [chemical binding]; other site 114615014897 Q-loop/lid; other site 114615014898 ABC transporter signature motif; other site 114615014899 Walker B; other site 114615014900 D-loop; other site 114615014901 phosphonate C-P lyase system protein PhnK; Provisional; Region: phnK; PRK11701 114615014902 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 114615014903 Walker A/P-loop; other site 114615014904 ATP binding site [chemical binding]; other site 114615014905 Q-loop/lid; other site 114615014906 ABC transporter signature motif; other site 114615014907 Walker B; other site 114615014908 D-loop; other site 114615014909 H-loop/switch region; other site 114615014910 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 114615014911 Phosphonate metabolism protein PhnJ; Region: PhnJ; pfam06007 114615014912 Bacterial phosphonate metabolism protein (PhnI); Region: PhnI; pfam05861 114615014913 Bacterial phosphonate metabolism protein (PhnH); Region: PhnH; pfam05845 114615014914 Phosphonate metabolism protein PhnG; Region: PhnG; pfam06754 114615014915 phosphonates metabolism transcriptional regulator PhnF; Region: C_P_lyase_phnF; TIGR02325 114615014916 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 114615014917 DNA-binding site [nucleotide binding]; DNA binding site 114615014918 UTRA domain; Region: UTRA; pfam07702 114615014919 Enterobacter aerogenes GpdQ and related proteins, metallophosphatase domain; Region: MPP_GpdQ; cd07402 114615014920 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 114615014921 active site 114615014922 metal binding site [ion binding]; metal-binding site 114615014923 hexamer interface [polypeptide binding]; other site 114615014924 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 114615014925 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 114615014926 Walker A/P-loop; other site 114615014927 ATP binding site [chemical binding]; other site 114615014928 Q-loop/lid; other site 114615014929 ABC transporter signature motif; other site 114615014930 Walker B; other site 114615014931 D-loop; other site 114615014932 H-loop/switch region; other site 114615014933 TOBE domain; Region: TOBE_2; pfam08402 114615014934 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 114615014935 putative PBP binding loops; other site 114615014936 dimer interface [polypeptide binding]; other site 114615014937 ABC-ATPase subunit interface; other site 114615014938 ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555 114615014939 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 114615014940 dimer interface [polypeptide binding]; other site 114615014941 conserved gate region; other site 114615014942 ABC-ATPase subunit interface; other site 114615014943 ABC-type Fe3+ transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: AfuA; COG1840 114615014944 Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416 114615014945 phosphonate ABC transporter, permease protein PhnE; Region: PhnE; TIGR01097 114615014946 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 114615014947 dimer interface [polypeptide binding]; other site 114615014948 conserved gate region; other site 114615014949 ABC-ATPase subunit interface; other site 114615014950 phosphonate ABC transporter, permease protein PhnE; Region: PhnE; TIGR01097 114615014951 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 114615014952 dimer interface [polypeptide binding]; other site 114615014953 conserved gate region; other site 114615014954 putative PBP binding loops; other site 114615014955 ABC-ATPase subunit interface; other site 114615014956 phosphonate ABC transporter, periplasmic phosphonate binding protein; Region: PhnD; TIGR03431 114615014957 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cl17432 114615014958 substrate binding pocket [chemical binding]; other site 114615014959 membrane-bound complex binding site; other site 114615014960 phosphonate ABC transporter, ATP-binding protein; Region: ABC_phnC; TIGR02315 114615014961 ATP-binding cassette domain of the binding protein-dependent phosphonate transport system; Region: ABC_PhnC_transporter; cd03256 114615014962 Walker A/P-loop; other site 114615014963 ATP binding site [chemical binding]; other site 114615014964 Q-loop/lid; other site 114615014965 ABC transporter signature motif; other site 114615014966 Walker B; other site 114615014967 D-loop; other site 114615014968 H-loop/switch region; other site 114615014969 phosphonate metabolim protein, transferase hexapeptide repeat family; Region: phn_thr-fam; TIGR03308 114615014970 Xenobiotic acyltransferase (XAT): The XAT class of hexapeptide acyltransferases is composed of a large number of microbial enzymes that catalyze the CoA-dependent acetylation of a variety of hydroxyl-bearing acceptors such as chloramphenicol and...; Region: LbH_XAT; cd03349 114615014971 trimer interface [polypeptide binding]; other site 114615014972 active site 114615014973 substrate binding site [chemical binding]; other site 114615014974 CoA binding site [chemical binding]; other site 114615014975 phosphonate metabolism protein PhnM; Provisional; Region: PRK15446 114615014976 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 114615014977 active site 114615014978 putative phosphonate metabolism protein; Region: Phn_opern_protn; TIGR03223 114615014979 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 114615014980 Mechanosensitive ion channel; Region: MS_channel; pfam00924 114615014981 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 114615014982 classical (c) SDRs; Region: SDR_c; cd05233 114615014983 NAD(P) binding site [chemical binding]; other site 114615014984 active site 114615014985 Predicted acetamidase/formamidase [Energy production and conversion]; Region: COG2421 114615014986 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 114615014987 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 114615014988 dimer interface [polypeptide binding]; other site 114615014989 conserved gate region; other site 114615014990 putative PBP binding loops; other site 114615014991 ABC-ATPase subunit interface; other site 114615014992 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 114615014993 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 114615014994 Walker A/P-loop; other site 114615014995 ATP binding site [chemical binding]; other site 114615014996 Q-loop/lid; other site 114615014997 ABC transporter signature motif; other site 114615014998 Walker B; other site 114615014999 D-loop; other site 114615015000 H-loop/switch region; other site 114615015001 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cl17432 114615015002 NMT1/THI5 like; Region: NMT1; pfam09084 114615015003 Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450 114615015004 Peroxiredoxin (PRX) family, Typical 2-Cys PRX subfamily; PRXs are thiol-specific antioxidant (TSA) proteins, which confer a protective role in cells through its peroxidase activity by reducing hydrogen peroxide, peroxynitrite, and organic hydroperoxides; Region: PRX_Typ2cys; cd03015 114615015005 dimer interface [polypeptide binding]; other site 114615015006 decamer (pentamer of dimers) interface [polypeptide binding]; other site 114615015007 catalytic triad [active] 114615015008 peroxidatic and resolving cysteines [active] 114615015009 alkylhydroperoxidase, AhpD family; Region: ahpD; TIGR00777 114615015010 Carboxymuconolactone decarboxylase family; Region: CMD; pfam02627 114615015011 Type I periplasmic ligand-binding domain of uncharacterized ABC (ATPase Binding Cassette)-type active transport systems that are predicted to be involved in uptake of amino acids, peptides, or inorganic ions; Region: PBP1_ABC_ligand_binding_like_8; cd06343 114615015012 Periplasmic binding protein; Region: Peripla_BP_6; pfam13458 114615015013 putative ligand binding site [chemical binding]; other site 114615015014 TRAP transporter solute receptor, TAXI family; Region: TRAP_TAXI; TIGR02122 114615015015 Phosphoribosyltransferase (PRTase) type II; This family contains two enzymes that play an important role in NAD production by either allowing quinolinic acid (QA) , quinolinate phosphoribosyl transferase (QAPRTase), or nicotinic acid (NA), nicotinate...; Region: PRTase_typeII; cl17275 114615015016 putative molybdenum utilization protein ModD; Region: modD; TIGR01334 114615015017 active site 114615015018 Protein of unknown function (DUF2478); Region: DUF2478; pfam10649 114615015019 Molybdopterin-binding protein [Coenzyme metabolism]; Region: MopI; COG3585 114615015020 Ferredoxin-like protein [Energy production and conversion]; Region: FixX; COG2440 114615015021 oxidoreductase; Provisional; Region: PRK10015 114615015022 Electron transfer flavoprotein, alpha subunit [Energy production and conversion]; Region: FixB; COG2025 114615015023 The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_alpha; cd01715 114615015024 Electron transfer flavoprotein FAD-binding domain; Region: ETF_alpha; pfam00766 114615015025 The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_beta; cd01714 114615015026 Ligand binding site [chemical binding]; other site 114615015027 Electron transfer flavoprotein domain; Region: ETF; pfam01012 114615015028 nitrogenase stabilizing/protective protein; Provisional; Region: nifW; PRK00810 114615015029 serine O-acetyltransferase; Region: cysE; TIGR01172 114615015030 Serine acetyltransferase, N-terminal; Region: SATase_N; cl05762 114615015031 Serine acetyltransferase (SAT): SAT catalyzes the CoA-dependent acetylation of the side chain hydroxyl group of L-serine to form O-acetylserine, as the first step of a two-step biosynthetic pathway in bacteria and plants leading to the formation of...; Region: LbH_SAT; cd03354 114615015032 trimer interface [polypeptide binding]; other site 114615015033 active site 114615015034 substrate binding site [chemical binding]; other site 114615015035 CoA binding site [chemical binding]; other site 114615015036 homocitrate synthase NifV; Region: nifV_homocitr; TIGR02660 114615015037 Streptomyces rubellomurinus FrbC and related proteins, catalytic TIM barrel domain; Region: DRE_TIM_NifV; cd07939 114615015038 active site 114615015039 catalytic residues [active] 114615015040 metal binding site [ion binding]; metal-binding site 114615015041 Chorismate mutase type II; Region: CM_2; cl00693 114615015042 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 114615015043 metal binding site 2 [ion binding]; metal-binding site 114615015044 putative DNA binding helix; other site 114615015045 metal binding site 1 [ion binding]; metal-binding site 114615015046 dimer interface [polypeptide binding]; other site 114615015047 structural Zn2+ binding site [ion binding]; other site 114615015048 NifQ; Region: NifQ; pfam04891 114615015049 nitrogenase reductase; Reviewed; Region: nifH; PRK13234 114615015050 NifH gene encodes component II (iron protein) of nitrogenase. Nitrogenase is responsible for the biological nitrogen fixation, i.e. reduction of molecular nitrogen to ammonia. NifH consists of two oxygen-sensitive metallosulfur proteins: the...; Region: NifH; cd02040 114615015051 Nucleotide-binding sites [chemical binding]; other site 114615015052 Walker A motif; other site 114615015053 Switch I region of nucleotide binding site; other site 114615015054 Fe4S4 binding sites [ion binding]; other site 114615015055 Switch II region of nucleotide binding site; other site 114615015056 Response regulator receiver domain; Region: Response_reg; pfam00072 114615015057 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 114615015058 active site 114615015059 phosphorylation site [posttranslational modification] 114615015060 intermolecular recognition site; other site 114615015061 dimerization interface [polypeptide binding]; other site 114615015062 Arsenate Reductase (ArsC) family, 15kD protein subfamily; composed of proteins of unknown function with similarity to thioredoxin-fold arsenic reductases, ArsC. It is encoded by an ORF present in a gene cluster associated with nitrogen fixation that also...; Region: ArsC_15kD; cd03033 114615015063 ArsC family; Region: ArsC; pfam03960 114615015064 putative catalytic residues [active] 114615015065 Thioredoxin (TRX)-like [2Fe-2S] Ferredoxin (Fd) family; composed of [2Fe-2S] Fds with a TRX fold (TRX-like Fds) and proteins containing domains similar to TRX-like Fd including formate dehydrogenases, NAD-reducing hydrogenases and the subunit E of NADH:...; Region: TRX_Fd_family; cd02980 114615015066 dimer interface [polypeptide binding]; other site 114615015067 [2Fe-2S] cluster binding site [ion binding]; other site 114615015068 Glutaredoxin (GRX) family, PKC-interacting cousin of TRX (PICOT)-like subfamily; composed of PICOT and GRX-PICOT-like proteins. The non-PICOT members of this family contain only the GRX-like domain, whereas PICOT contains an N-terminal TRX-like domain...; Region: GRX_PICOT_like; cd03028 114615015069 putative GSH binding site [chemical binding]; other site 114615015070 catalytic residues [active] 114615015071 Stress-induced morphogen (activity unknown) [Signal transduction mechanisms]; Region: BolA; COG0271 114615015072 FeS assembly SUF system protein; Region: SUF_assoc; TIGR02945 114615015073 Dienelactone hydrolase and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG0412 114615015074 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3666 114615015075 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 114615015076 Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751 114615015077 Truncated hemoglobins (trHbs) are a family of oxygen-binding heme proteins found in cyanobacteria, eubacteria, unicellular eukaryotes, and plants. The truncated hemoglobins have a characteristic two-over-two alpha helical folding pattern that is distinct...; Region: Trunc_globin; cd00454 114615015078 apolar tunnel; other site 114615015079 heme binding site [chemical binding]; other site 114615015080 dimerization interface [polypeptide binding]; other site 114615015081 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 114615015082 Ferredoxin [Energy production and conversion]; Region: Fdx; COG0633 114615015083 catalytic loop [active] 114615015084 iron binding site [ion binding]; other site 114615015085 Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WecE; COG0399 114615015086 3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616 114615015087 inhibitor-cofactor binding pocket; inhibition site 114615015088 pyridoxal 5'-phosphate binding site [chemical binding]; other site 114615015089 catalytic residue [active] 114615015090 Protein of unknown function (DUF3024); Region: DUF3024; pfam11225 114615015091 NifZ domain; Region: NifZ; pfam04319 114615015092 NifZ domain; Region: NifZ; pfam04319 114615015093 LRV protein FeS4 cluster; Region: LRV_FeS; pfam05484 114615015094 Fe-S cluster assembly scaffold protein [Posttranslational modification, protein turnover, chaperones]; Region: sufA; COG0316 114615015095 4Fe-4S dicluster domain; Region: Fer4_7; pfam12838 114615015096 nitrogenase cofactor biosynthesis protein NifB; Region: nifB; TIGR01290 114615015097 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 114615015098 FeS/SAM binding site; other site 114615015099 NifB belongs to a family of iron-molybdenum cluster-binding proteins that includes NifX, and NifY, all of which are involved in the synthesis of an iron-molybdenum cofactor (FeMo-co) that binds the active site of the dinitrogenase enzyme as part of...; Region: NifB; cd00852 114615015100 SIR2-like domain; Region: SIR2_2; pfam13289 114615015101 NifT/FixU protein; Region: NifT; pfam06988 114615015102 Cysteine sulfinate desulfinase/cysteine desulfurase and related enzymes [Amino acid transport and metabolism]; Region: NifS; COG1104 114615015103 cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402 114615015104 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 114615015105 catalytic residue [active] 114615015106 NifU-like domain; Region: NifU; cl00484 114615015107 Iron-sulfur cluster assembly accessory protein; Region: TIGR00049 114615015108 Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cd03467 114615015109 iron-sulfur cluster [ion binding]; other site 114615015110 [2Fe-2S] cluster binding site [ion binding]; other site 114615015111 Rhodanese-related sulfurtransferase [Inorganic ion transport and metabolism]; Region: SseA; COG2897 114615015112 Thiosulfate sulfurtransferase (TST), N-terminal, inactive domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the 1st repeat, which does not contain the catalytically active Cys residue. The role of the 1st repeat is uncertain, but it...; Region: TST_Repeat_1; cd01448 114615015113 active site residue [active] 114615015114 Thiosulfate sulfurtransferase (TST), C-terminal, catalytic domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the second repeat. Only the second repeat contains the catalytically active Cys residue; Region: TST_Repeat_2; cd01449 114615015115 active site residue [active] 114615015116 Hemimethylated DNA-binding protein YccV like; Region: YccV-like; pfam08755 114615015117 ferredoxin III, nif-specific; Region: fdxN_nitrog; TIGR02936 114615015118 4Fe-4S binding domain; Region: Fer4; cl02805 114615015119 Rop-like; Region: Rop-like; pfam05082 114615015120 probable nitrogen fixation protein; Region: TIGR02935 114615015121 NifX belongs to a family of iron-molybdenum cluster-binding proteins that includes NifB, and NifY, all of which are involved in the synthesis of an iron-molybdenum cofactor (FeMo-co) that binds the active site of the dinitrogenase enzyme. The protein...; Region: NifX; cd00853 114615015122 Nitrogenase_nifN1: A subgroup of the NifN subunit of the NifEN complex: NifN forms an alpha2beta2 tetramer with NifE. NifN and nifE are structurally homologous to nitrogenase MoFe protein beta and alpha subunits respectively. NifEN participates in the...; Region: Nitrogenase_NifN_1; cd01966 114615015123 Nitrogenase component 1 type Oxidoreductase; Region: Oxidored_nitro; pfam00148 114615015124 nitrogenase molybdenum-iron cofactor biosynthesis protein NifE; Region: nifE; TIGR01283 114615015125 Nitrogenase_NifE_I: a subgroup of the NifE subunit of the NifEN complex: NifE forms an alpha2beta2 tetramer with NifN. NifE and NifN are structurally homologous to nitrogenase MoFe protein alpha and beta subunits respectively. NifEN participates in the...; Region: Nitrogenase_NifE_I; cd01968 114615015126 BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324 114615015127 nitrogenase molybdenum-iron protein beta chain; Region: nifK; TIGR01286 114615015128 Domain of unknown function (DUF3364); Region: DUF3364; pfam11844 114615015129 Nitrogenase_MoFe_beta: Nitrogenase MoFe protein, beta subunit. The nitrogenase enzyme catalyzes the ATP-dependent reduction of dinitrogen to ammonia. The Molybdenum (Mo-) nitrogenase is the most widespread and best characterized of these systems; Region: Nitrogenase_MoFe_beta; cd01974 114615015130 MoFe protein beta/alpha subunit interactions; other site 114615015131 Beta subunit P cluster binding residues; other site 114615015132 MoFe protein beta subunit/Fe protein contacts; other site 114615015133 MoFe protein dimer/ dimer interactions; other site 114615015134 Nitrogenase molybdenum-iron protein, alpha and beta chains [Energy production and conversion]; Region: NifD; COG2710 114615015135 Nitrogenase_MoFe_alpha_II: Nitrogenase MoFe protein, beta subunit. A group of proteins similar to the alpha subunit of the MoFe protein of the molybdenum (Mo-) nitrogenase. The nitrogenase enzyme catalyzes the ATP-dependent reduction of dinitrogen to...; Region: Nitrogenase_MoFe_alpha; cd01976 114615015136 MoFe protein alpha/beta subunit interactions; other site 114615015137 Alpha subunit P cluster binding residues; other site 114615015138 FeMoco binding residues [chemical binding]; other site 114615015139 MoFe protein alpha subunit/Fe protein contacts; other site 114615015140 MoFe protein dimer/ dimer interactions; other site 114615015141 nitrogenase reductase; Reviewed; Region: nifH; PRK13234 114615015142 NifH gene encodes component II (iron protein) of nitrogenase. Nitrogenase is responsible for the biological nitrogen fixation, i.e. reduction of molecular nitrogen to ammonia. NifH consists of two oxygen-sensitive metallosulfur proteins: the...; Region: NifH; cd02040 114615015143 Nucleotide-binding sites [chemical binding]; other site 114615015144 Walker A motif; other site 114615015145 Switch I region of nucleotide binding site; other site 114615015146 Fe4S4 binding sites [ion binding]; other site 114615015147 Switch II region of nucleotide binding site; other site 114615015148 Response regulator receiver domain; Region: Response_reg; pfam00072 114615015149 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 114615015150 active site 114615015151 phosphorylation site [posttranslational modification] 114615015152 intermolecular recognition site; other site 114615015153 dimerization interface [polypeptide binding]; other site 114615015154 Cysteine desulfurase SufE subunit [Posttranslational modification, protein turnover, chaperones]; Region: sufE; COG2166 114615015155 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 114615015156 Cysteine desulfurase (SufS)-like. This family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to cysteine desulfurase (SufS) and selenocysteine lyase. SufS...; Region: SufS_like; cd06453 114615015157 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 114615015158 catalytic residue [active] 114615015159 FeS assembly protein SufD; Region: sufD; TIGR01981 114615015160 Uncharacterized protein family (UPF0051); Region: UPF0051; pfam01458 114615015161 Cysteine desulfurase activator ATPase [Posttranslational modification, protein turnover, chaperones]; Region: sufC; COG0396 114615015162 ABC-type transport system involved in Fe-S cluster assembly, ATPase component; Region: ABC_FeS_Assembly; cd03217 114615015163 Walker A/P-loop; other site 114615015164 ATP binding site [chemical binding]; other site 114615015165 Q-loop/lid; other site 114615015166 ABC transporter signature motif; other site 114615015167 Walker B; other site 114615015168 D-loop; other site 114615015169 H-loop/switch region; other site 114615015170 cysteine desulfurase activator complex subunit SufB; Provisional; Region: PRK11814 114615015171 putative ABC transporter; Region: ycf24; CHL00085 114615015172 hypothetical protein; Provisional; Region: PRK13795 114615015173 Nif-specific regulatory protein; Region: nifA; TIGR01817 114615015174 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 114615015175 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 114615015176 Walker A motif; other site 114615015177 ATP binding site [chemical binding]; other site 114615015178 Walker B motif; other site 114615015179 arginine finger; other site 114615015180 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 114615015181 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 114615015182 classical (c) SDRs; Region: SDR_c; cd05233 114615015183 NAD(P) binding site [chemical binding]; other site 114615015184 active site 114615015185 selenium-dependent molybdenum hydroxylase system protein, YqeB family; Region: matur_yqeB; TIGR03309 114615015186 BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324 114615015187 classical (c) SDR, subgroup 1; Region: SDR_c1; cd05355 114615015188 short chain dehydrogenase; Provisional; Region: PRK06701 114615015189 NAD binding site [chemical binding]; other site 114615015190 metal binding site [ion binding]; metal-binding site 114615015191 active site 114615015192 Protein of unknown function (DUF2934); Region: DUF2934; pfam11154 114615015193 HAMP domain; Region: HAMP; pfam00672 114615015194 dimerization interface [polypeptide binding]; other site 114615015195 Histidine kinase; Region: HisKA_3; pfam07730 114615015196 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518 114615015197 Mg2+ binding site [ion binding]; other site 114615015198 G-X-G motif; other site 114615015199 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 114615015200 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 114615015201 active site 114615015202 phosphorylation site [posttranslational modification] 114615015203 intermolecular recognition site; other site 114615015204 dimerization interface [polypeptide binding]; other site 114615015205 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 114615015206 DNA binding residues [nucleotide binding] 114615015207 dimerization interface [polypeptide binding]; other site 114615015208 S-formylglutathione hydrolase; Region: PLN02442 114615015209 S-formylglutathione hydrolase; Region: fghA_ester_D; TIGR02821 114615015210 Protein of unknown function (DUF2380); Region: DUF3280; pfam11684 114615015211 Periplasmic binding protein; Region: Peripla_BP_6; pfam13458 114615015212 Periplasmic binding domain of ATP-binding cassette transporter-like systems that belong to the type I periplasmic binding fold protein superfamily; Region: PBP1_ABC_transporter_LIVBP_like; cd06268 114615015213 ligand binding site [chemical binding]; other site 114615015214 PQQ-dependent catabolism-associated beta-propeller protein; Region: PQQ_ABC_repeats; TIGR03866 114615015215 40-residue YVTN family beta-propeller repeat; Region: beta_rpt_yvtn; TIGR02276 114615015216 40-residue YVTN family beta-propeller repeat; Region: beta_rpt_yvtn; TIGR02276 114615015217 40-residue YVTN family beta-propeller repeat; Region: beta_rpt_yvtn; TIGR02276 114615015218 ABC transporter, ATP-binding subunit, PQQ-dependent alcohol dehydrogenase system; Region: PQQ_ABC_ATP; TIGR03864 114615015219 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 114615015220 Walker A/P-loop; other site 114615015221 ATP binding site [chemical binding]; other site 114615015222 Q-loop/lid; other site 114615015223 ABC transporter signature motif; other site 114615015224 Walker B; other site 114615015225 D-loop; other site 114615015226 H-loop/switch region; other site 114615015227 ABC-2 type transporter; Region: ABC2_membrane; cl17235 114615015228 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 114615015229 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 114615015230 active site residue [active] 114615015231 quinoprotein dehydrogenase-associated probable ABC transporter substrate-binding protein; Region: ABC_peri_MoxJ_2; TIGR03871 114615015232 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 114615015233 substrate binding pocket [chemical binding]; other site 114615015234 membrane-bound complex binding site; other site 114615015235 hinge residues; other site 114615015236 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 114615015237 Sulfur oxidation protein SoxY; Region: SoxY; pfam13501 114615015238 Sulphur oxidation protein SoxZ; Region: SoxZ; pfam08770 114615015239 ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components [Inorganic ion transport and metabolism]; Region: TauA; COG0715 114615015240 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 114615015241 substrate binding pocket [chemical binding]; other site 114615015242 membrane-bound complex binding site; other site 114615015243 hinge residues; other site 114615015244 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 114615015245 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 114615015246 dimer interface [polypeptide binding]; other site 114615015247 conserved gate region; other site 114615015248 putative PBP binding loops; other site 114615015249 ABC-ATPase subunit interface; other site 114615015250 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 114615015251 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 114615015252 Walker A/P-loop; other site 114615015253 ATP binding site [chemical binding]; other site 114615015254 Q-loop/lid; other site 114615015255 ABC transporter signature motif; other site 114615015256 Walker B; other site 114615015257 D-loop; other site 114615015258 H-loop/switch region; other site 114615015259 EthD domain; Region: EthD; cl17553 114615015260 coenzyme PQQ synthesis protein PqqA; Provisional; Region: pqqA; PRK00284 114615015261 PQQ-dependent dehydrogenase, methanol/ethanol family; Region: PQQ_enz_alc_DH; TIGR03075 114615015262 Ethanol dehydrogenase, a bacterial quinoprotein (PQQ-dependent type I alcohol dehydrogenase); Region: PQQ_ADH_I; cd10277 114615015263 dimer interface [polypeptide binding]; other site 114615015264 Trp docking motif [polypeptide binding]; other site 114615015265 active site 114615015266 Cytochrome C oxidase, cbb3-type, subunit III; Region: Cytochrome_CBB3; pfam13442 114615015267 Bacterial periplasmic substrate-binding proteins; Region: PBPb; smart00062 114615015268 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 114615015269 substrate binding pocket [chemical binding]; other site 114615015270 membrane-bound complex binding site; other site 114615015271 hinge residues; other site 114615015272 DNA-binding transcriptional activator FeaR; Provisional; Region: PRK09685 114615015273 PQQ-dependent dehydrogenase, methanol/ethanol family; Region: PQQ_enz_alc_DH; TIGR03075 114615015274 Large subunit of methanol dehydrogenase (moxF); Region: PQQ_MDH; cd10278 114615015275 Trp docking motif [polypeptide binding]; other site 114615015276 dimer interface [polypeptide binding]; other site 114615015277 active site 114615015278 small subunit binding site [polypeptide binding]; other site 114615015279 Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010 114615015280 c-type cytochrome, methanol metabolism-related; Region: 4cys_cytochr; TIGR03874 114615015281 Zn-dependent alcohol dehydrogenases, class III [Energy production and conversion]; Region: AdhC; COG1062 114615015282 class III alcohol dehydrogenases; Region: alcohol_DH_class_III; cd08300 114615015283 substrate binding site [chemical binding]; other site 114615015284 catalytic Zn binding site [ion binding]; other site 114615015285 NAD binding site [chemical binding]; other site 114615015286 structural Zn binding site [ion binding]; other site 114615015287 dimer interface [polypeptide binding]; other site 114615015288 glutathione-dependent formaldehyde-activating enzyme; Provisional; Region: PRK05417 114615015289 Aerobic-type carbon monoxide dehydrogenase, small subunit CoxS/CutS homologs [Energy production and conversion]; Region: CoxS; COG2080 114615015290 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 114615015291 catalytic loop [active] 114615015292 iron binding site [ion binding]; other site 114615015293 [2Fe-2S] binding domain; Region: Fer2_2; pfam01799 114615015294 Aerobic-type carbon monoxide dehydrogenase, large subunit CoxL/CutL homologs [Energy production and conversion]; Region: CoxL; COG1529 114615015295 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; smart01008 114615015296 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 114615015297 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 114615015298 Transposase; Region: HTH_Tnp_1; pfam01527 114615015299 Predicted acetamidase/formamidase [Energy production and conversion]; Region: COG2421 114615015300 cytochrome c oxidase accessory protein FixG; Region: ccoG_rdxA_fixG; TIGR02745 114615015301 Ubp3 associated protein Bre5; Region: Bre5; pfam11614 114615015302 2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179 114615015303 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557 114615015304 SOUL heme-binding protein; Region: SOUL; pfam04832 114615015305 Putative cyclase; Region: Cyclase; pfam04199 114615015306 2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179 114615015307 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557 114615015308 NMT1-like family; Region: NMT1_2; pfam13379 114615015309 ABC transporter, substrate-binding protein, aliphatic sulfonates family; Region: SsuA_fam; TIGR01728 114615015310 Transcriptional regulators [Transcription]; Region: GntR; COG1802 114615015311 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 114615015312 DNA-binding site [nucleotide binding]; DNA binding site 114615015313 FCD domain; Region: FCD; pfam07729 114615015314 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 114615015315 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 114615015316 Walker A/P-loop; other site 114615015317 ATP binding site [chemical binding]; other site 114615015318 Q-loop/lid; other site 114615015319 ABC transporter signature motif; other site 114615015320 Walker B; other site 114615015321 D-loop; other site 114615015322 H-loop/switch region; other site 114615015323 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 114615015324 dimer interface [polypeptide binding]; other site 114615015325 conserved gate region; other site 114615015326 putative PBP binding loops; other site 114615015327 ABC-ATPase subunit interface; other site 114615015328 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 114615015329 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 114615015330 putative PBP binding loops; other site 114615015331 dimer interface [polypeptide binding]; other site 114615015332 ABC-ATPase subunit interface; other site 114615015333 flavocytochrome c; Region: flavo_cyto_c; TIGR01813 114615015334 Isochorismatase family; Region: Isochorismatase; pfam00857 114615015335 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cd00431 114615015336 catalytic triad [active] 114615015337 conserved cis-peptide bond; other site 114615015338 N-methylhydantoinase A/acetone carboxylase, beta subunit [Amino acid transport and metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: HyuA; COG0145 114615015339 Hydantoinase/oxoprolinase N-terminal region; Region: Hydant_A_N; pfam05378 114615015340 Hydantoinase/oxoprolinase; Region: Hydantoinase_A; pfam01968 114615015341 N-methylhydantoinase B/acetone carboxylase, alpha subunit [Amino acid transport and metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: HyuB; COG0146 114615015342 Hydantoinase B/oxoprolinase; Region: Hydantoinase_B; pfam02538 114615015343 Members of the ICL/PEPM enzyme family catalyze either P-C or C-C bond formation/cleavage. Known members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate hydrolase (OAH), isocitrate...; Region: ICL_PEPM; cd00377 114615015344 Phosphoenolpyruvate phosphomutase; Region: PEP_mutase; pfam13714 114615015345 tetramer interface [polypeptide binding]; other site 114615015346 active site 114615015347 Mg2+/Mn2+ binding site [ion binding]; other site 114615015348 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410 114615015349 ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224 114615015350 Walker A/P-loop; other site 114615015351 ATP binding site [chemical binding]; other site 114615015352 Q-loop/lid; other site 114615015353 ABC transporter signature motif; other site 114615015354 Walker B; other site 114615015355 D-loop; other site 114615015356 H-loop/switch region; other site 114615015357 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411 114615015358 ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219 114615015359 Walker A/P-loop; other site 114615015360 ATP binding site [chemical binding]; other site 114615015361 Q-loop/lid; other site 114615015362 ABC transporter signature motif; other site 114615015363 Walker B; other site 114615015364 D-loop; other site 114615015365 H-loop/switch region; other site 114615015366 ABC-type branched-chain amino acid transport system, permease component [Amino acid transport and metabolism]; Region: LivM; COG4177 114615015367 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 114615015368 TM-ABC transporter signature motif; other site 114615015369 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 114615015370 TM-ABC transporter signature motif; other site 114615015371 ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683 114615015372 Type I periplasmic ligand-binding domain of uncharacterized ABC (ATPase Binding Cassette)-type active transport systems that are predicted to be involved in transport of amino acids, peptides, or inorganic ions; Region: PBP1_ABC_ligand_binding_like_6; cd06340 114615015373 putative ligand binding site [chemical binding]; other site 114615015374 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 114615015375 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 114615015376 DNA-binding site [nucleotide binding]; DNA binding site 114615015377 UTRA domain; Region: UTRA; pfam07702 114615015378 mycofactocin system FadH/OYE family oxidoreductase 2; Region: mycofact_OYE_2; TIGR03997 114615015379 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 114615015380 phosphate binding site [ion binding]; other site 114615015381 3-isopropylmalate dehydratase large subunit; Reviewed; Region: PRK00402 114615015382 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate; Region: IPMI; cd01583 114615015383 substrate binding site [chemical binding]; other site 114615015384 ligand binding site [chemical binding]; other site 114615015385 isopropylmalate isomerase small subunit; Provisional; Region: leuD; PRK01641 114615015386 Aconatase-like swivel domain of 3-isopropylmalate dehydratase and related uncharacterized proteins. 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate...; Region: IPMI_Swivel; cd01577 114615015387 substrate binding site [chemical binding]; other site 114615015388 Domain of unknown function (DUF892); Region: DUF892; pfam05974 114615015389 hypothetical protein; Provisional; Region: PRK08201 114615015390 Uncharacterized M20 Dipeptidases; Region: M20_dipept_like_3; cd05680 114615015391 metal binding site [ion binding]; metal-binding site 114615015392 putative dimer interface [polypeptide binding]; other site 114615015393 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 114615015394 SIR2-like domain; Region: SIR2_2; pfam13289 114615015395 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189 114615015396 Walker A motif; other site 114615015397 ATP binding site [chemical binding]; other site 114615015398 Walker B motif; other site 114615015399 TRAP transporter, DctM subunit; Region: dctM; TIGR00786 114615015400 DctM-like transporters; Region: DctM; pfam06808 114615015401 Tripartite ATP-independent periplasmic transporters, DctQ component; Region: DctQ; pfam04290 114615015402 TRAP-type C4-dicarboxylate transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: DctP; COG1638 114615015403 Bacterial extracellular solute-binding protein, family 7; Region: SBP_bac_7; pfam03480 114615015404 2-isopropylmalate synthase; Validated; Region: PRK00915 114615015405 2-isopropylmalate synthase (IPMS), N-terminal catalytic TIM barrel domain; Region: DRE_TIM_IPMS; cd07940 114615015406 active site 114615015407 catalytic residues [active] 114615015408 metal binding site [ion binding]; metal-binding site 114615015409 LeuA allosteric (dimerisation) domain; Region: LeuA_dimer; pfam08502 114615015410 Helix-turn-helix domain; Region: HTH_28; pfam13518 114615015411 Winged helix-turn helix; Region: HTH_29; pfam13551 114615015412 Homeodomain-like domain; Region: HTH_32; pfam13565 114615015413 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: Tra5; COG2801 114615015414 Integrase core domain; Region: rve; pfam00665 114615015415 Integrase core domain; Region: rve_3; pfam13683 114615015416 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 114615015417 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 114615015418 Beta-lactamase; Region: Beta-lactamase; pfam00144 114615015419 Protein of unknown function with HXXEE motif; Region: HXXEE; pfam13787 114615015420 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 114615015421 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 114615015422 ligand binding site [chemical binding]; other site 114615015423 flexible hinge region; other site 114615015424 Crp-like helix-turn-helix domain; Region: HTH_Crp_2; pfam13545 114615015425 SCP_bacterial: SCP-like extracellular protein domain, as found in bacteria and archaea. The wider family of SCP containing proteins includes plant pathogenesis-related protein 1 (PR-1), CRISPs, mammalian cysteine-rich secretory proteins, and allergen 5...; Region: SCP_bacterial; cd05379 114615015426 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3323 114615015427 drug resistance transporter, Bcr/CflA subfamily; Region: efflux_Bcr_CflA; TIGR00710 114615015428 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 114615015429 putative substrate translocation pore; other site 114615015430 Hemolysin activation/secretion protein [Intracellular trafficking and secretion]; Region: FhaC; COG2831 114615015431 POTRA domain, ShlB-type; Region: POTRA_2; pfam08479 114615015432 Haemolysin secretion/activation protein ShlB/FhaC/HecB; Region: ShlB; pfam03865 114615015433 Surface antigen; Region: Bac_surface_Ag; pfam01103 114615015434 FecR protein; Region: FecR; pfam04773 114615015435 CHASE2 is an extracellular sensory domain, which is present in various classes of transmembrane receptors that are parts of signal transduction pathways in bacteria; Region: CHASE2; smart01080 114615015436 PAS domain S-box; Region: sensory_box; TIGR00229 114615015437 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 114615015438 putative active site [active] 114615015439 heme pocket [chemical binding]; other site 114615015440 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 114615015441 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 114615015442 metal binding site [ion binding]; metal-binding site 114615015443 active site 114615015444 I-site; other site 114615015445 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 114615015446 polyphosphate:nucleotide phosphotransferase, PPK2 family; Region: PPK2_rel_1; TIGR03709 114615015447 NUDIX domain; Region: NUDIX; pfam00293 114615015448 nudix motif; other site 114615015449 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 114615015450 substrate binding pocket [chemical binding]; other site 114615015451 NMT1/THI5 like; Region: NMT1; pfam09084 114615015452 membrane-bound complex binding site; other site 114615015453 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 114615015454 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 114615015455 dimer interface [polypeptide binding]; other site 114615015456 conserved gate region; other site 114615015457 putative PBP binding loops; other site 114615015458 ABC-ATPase subunit interface; other site 114615015459 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 114615015460 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 114615015461 Walker A/P-loop; other site 114615015462 ATP binding site [chemical binding]; other site 114615015463 Q-loop/lid; other site 114615015464 ABC transporter signature motif; other site 114615015465 Walker B; other site 114615015466 D-loop; other site 114615015467 H-loop/switch region; other site 114615015468 sulfate ABC transporter, ATP-binding protein; Region: 3a0106s01; TIGR00968 114615015469 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 114615015470 Walker A/P-loop; other site 114615015471 ATP binding site [chemical binding]; other site 114615015472 Q-loop/lid; other site 114615015473 ABC transporter signature motif; other site 114615015474 Walker B; other site 114615015475 D-loop; other site 114615015476 H-loop/switch region; other site 114615015477 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 114615015478 dimer interface [polypeptide binding]; other site 114615015479 conserved gate region; other site 114615015480 ABC-ATPase subunit interface; other site 114615015481 ABC-type proline/glycine betaine transport systems, periplasmic components [Amino acid transport and metabolism]; Region: ProX; cl17891 114615015482 Periplasmic glycine betaine/choline-binding (lipo)protein of an ABC-type transport system (osmoprotectant binding protein) [Cell envelope biogenesis, outer membrane]; Region: OpuBC; COG1732 114615015483 Polysulfide-sulfurtransferase - Rhodanese Homology Domain. This domain is believed to serve as a polysulfide binding and transferase domain in anaerobic gram-negative bacteria, functioning in oxidative phosphorylation with polysulfide-sulfur as a...; Region: Polysulfide_ST; cd01447 114615015484 active site 114615015485 catalytic residue [active] 114615015486 Sulfatase; Region: Sulfatase; cl17466 114615015487 Protein of unknown function (DUF3592); Region: DUF3592; pfam12158 114615015488 short chain dehydrogenase; Provisional; Region: PRK06914 114615015489 17beta hydroxysteroid dehydrogenase-like, classical (c) SDRs; Region: 17beta-HSD-like_SDR_c; cd05374 114615015490 NADP binding site [chemical binding]; other site 114615015491 active site 114615015492 steroid binding site; other site 114615015493 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5330 114615015494 Uncharacterized protein conserved in bacteria (DUF2336); Region: DUF2336; pfam10098 114615015495 ketol-acid reductoisomerase; Provisional; Region: PRK05479 114615015496 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvN; pfam07991 114615015497 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvC; pfam01450 114615015498 Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280 114615015499 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 114615015500 S-adenosylmethionine binding site [chemical binding]; other site 114615015501 acetolactate synthase 3 regulatory subunit; Reviewed; Region: ilvH; PRK11895 114615015502 N-terminal ACT domain of the Escherichia coli IlvH-like regulatory subunit of acetohydroxyacid synthase (AHAS); Region: ACT_AHAS; cd04878 114615015503 putative valine binding site [chemical binding]; other site 114615015504 dimer interface [polypeptide binding]; other site 114615015505 Small subunit of acetolactate synthase; Region: ALS_ss_C; pfam10369 114615015506 Threonine dehydratase [Amino acid transport and metabolism]; Region: IlvA; COG1171 114615015507 Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562 114615015508 tetramer interface [polypeptide binding]; other site 114615015509 pyridoxal 5'-phosphate binding site [chemical binding]; other site 114615015510 catalytic residue [active] 114615015511 acetolactate synthase 3 catalytic subunit; Validated; Region: PRK09107 114615015512 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 114615015513 PYR/PP interface [polypeptide binding]; other site 114615015514 dimer interface [polypeptide binding]; other site 114615015515 TPP binding site [chemical binding]; other site 114615015516 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 114615015517 Thiamine pyrophosphate (TPP) family, Acetohydroxyacid synthase (AHAS) subfamily, TPP-binding module; composed of proteins similar to the large catalytic subunit of AHAS. AHAS catalyzes the condensation of two molecules of pyruvate to give the...; Region: TPP_AHAS; cd02015 114615015518 TPP-binding site [chemical binding]; other site 114615015519 dimer interface [polypeptide binding]; other site 114615015520 PIN domain of ribonucleases (toxins), VapC and FitB, of prokaryotic toxin/antitoxin operons, Pyrococcus horikoshii protein PH0500, and other similar bacterial and archaeal homologs; Region: PIN_VapC-FitB; cd09881 114615015521 oligomeric interface; other site 114615015522 putative active site [active] 114615015523 homodimer interface [polypeptide binding]; other site 114615015524 tRNA delta(2)-isopentenylpyrophosphate transferase; Reviewed; Region: miaA; PRK00091 114615015525 tRNA delta(2)-isopentenylpyrophosphate transferase [Translation, ribosomal structure and biogenesis]; Region: MiaA; COG0324 114615015526 Phosphoserine phosphatase [Amino acid transport and metabolism]; Region: SerB; COG0560 114615015527 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 114615015528 motif II; other site 114615015529 arsenical resistance protein ArsH; Region: resist_ArsH; TIGR02690 114615015530 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 114615015531 periplasmic serine protease, Do/DeqQ family; Region: degP_htrA_DO; TIGR02037 114615015532 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 114615015533 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 114615015534 protein binding site [polypeptide binding]; other site 114615015535 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 114615015536 protein binding site [polypeptide binding]; other site 114615015537 Uncharacterized protein conserved in bacteria (DUF2065); Region: DUF2065; pfam09838 114615015538 HflC protein; Region: hflC; TIGR01932 114615015539 Band_7_HflC: The band 7 domain of flotillin (reggie) like proteins. This group includes proteins similar to prokaryotic HlfC (High frequency of lysogenization C). Although many members of the band 7 family are lipid raft associated, prokaryote plasma...; Region: Band_7_HflC; cd03405 114615015540 Band_7_HflK: The band 7 domain of flotillin (reggie) like proteins. This group includes proteins similar to prokaryotic HlfK (High frequency of lysogenization K). Although many members of the band 7 family are lipid raft associated, prokaryote plasma...; Region: Band_7_HflK; cd03404 114615015541 HflK protein; Region: hflK; TIGR01933 114615015542 Dihydrofolate reductase [Coenzyme metabolism]; Region: FolA; COG0262 114615015543 Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5; Region: DHFR; cd00209 114615015544 folate binding site [chemical binding]; other site 114615015545 NADP+ binding site [chemical binding]; other site 114615015546 Histone acetyltransferase HPA2 and related acetyltransferases [Transcription / General function prediction only]; Region: WecD; COG0454 114615015547 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 114615015548 Coenzyme A binding pocket [chemical binding]; other site 114615015549 thymidylate synthase; Reviewed; Region: thyA; PRK01827 114615015550 Thymidylate synthase and pyrimidine hydroxymethylase: Thymidylate synthase (TS) and deoxycytidylate hydroxymethylase (dCMP-HMase) are homologs that catalyze analogous alkylation of C5 of pyrimidine nucleotides. Both enzymes are involved in the...; Region: TS_Pyrimidine_HMase; cd00351 114615015551 dimerization interface [polypeptide binding]; other site 114615015552 active site 114615015553 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3333 114615015554 Tripartite tricarboxylate transporter TctB family; Region: TctB; pfam07331 114615015555 Chromate transporter; Region: Chromate_transp; pfam02417 114615015556 Chromate transporter; Region: Chromate_transp; pfam02417 114615015557 Stringent starvation protein B; Region: SspB; pfam04386 114615015558 fumarate hydratase; Reviewed; Region: fumC; PRK00485 114615015559 Class II fumarases; Region: Fumarase_classII; cd01362 114615015560 active site 114615015561 tetramer interface [polypeptide binding]; other site 114615015562 Domain of unknown function (DUF4169); Region: DUF4169; pfam13770 114615015563 Ribbon-helix-helix domain; Region: RHH_4; pfam13467 114615015564 FeoA domain; Region: FeoA; cl00838 114615015565 Ferrous iron transport protein B (FeoB) family; Region: FeoB; cd01879 114615015566 ferrous iron transporter FeoB; Region: feoB; TIGR00437 114615015567 G1 box; other site 114615015568 GTP/Mg2+ binding site [chemical binding]; other site 114615015569 Switch I region; other site 114615015570 G2 box; other site 114615015571 G3 box; other site 114615015572 Switch II region; other site 114615015573 G4 box; other site 114615015574 G5 box; other site 114615015575 Nucleoside recognition; Region: Gate; pfam07670 114615015576 Ferrous iron transport protein B C terminus; Region: FeoB_C; pfam07664 114615015577 Nucleoside recognition; Region: Gate; pfam07670 114615015578 Putative NADPH-quinone reductase (modulator of drug activity B) [General function prediction only]; Region: MdaB; COG2249 114615015579 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 114615015580 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 114615015581 LysR family transcriptional regulator; Provisional; Region: PRK14997 114615015582 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 114615015583 putative effector binding pocket; other site 114615015584 dimerization interface [polypeptide binding]; other site 114615015585 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312 114615015586 Carboxylesterase family; Region: COesterase; pfam00135 114615015587 substrate binding pocket [chemical binding]; other site 114615015588 catalytic triad [active] 114615015589 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 114615015590 4-hydroxyphenylpyruvate dioxygenase and related hemolysins [Amino acid transport and metabolism / General function prediction only]; Region: COG3185 114615015591 N-terminal domain of 4-hydroxyphenylpyruvate dioxygenase (HPPD) and hydroxymandelate Synthase (HmaS); Region: HPPD_N_like; cd08342 114615015592 dimer interface [polypeptide binding]; other site 114615015593 C-terminal domain of 4-hydroxyphenylpyruvate dioxygenase (HppD) and hydroxymandelate Synthase (HmaS); Region: HPPD_C_like; cd07250 114615015594 active site 114615015595 Fe binding site [ion binding]; other site 114615015596 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410 114615015597 ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224 114615015598 Walker A/P-loop; other site 114615015599 ATP binding site [chemical binding]; other site 114615015600 Q-loop/lid; other site 114615015601 ABC transporter signature motif; other site 114615015602 Walker B; other site 114615015603 D-loop; other site 114615015604 H-loop/switch region; other site 114615015605 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411 114615015606 ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219 114615015607 Walker A/P-loop; other site 114615015608 ATP binding site [chemical binding]; other site 114615015609 Q-loop/lid; other site 114615015610 ABC transporter signature motif; other site 114615015611 Walker B; other site 114615015612 D-loop; other site 114615015613 H-loop/switch region; other site 114615015614 ABC-type branched-chain amino acid transport system, permease component [Amino acid transport and metabolism]; Region: LivM; COG4177 114615015615 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 114615015616 TM-ABC transporter signature motif; other site 114615015617 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 114615015618 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 114615015619 TM-ABC transporter signature motif; other site 114615015620 Periplasmic binding protein; Region: Peripla_BP_6; pfam13458 114615015621 Periplasmic binding domain of ATP-binding cassette transporter-like systems that belong to the type I periplasmic binding fold protein superfamily; Region: PBP1_ABC_transporter_LIVBP_like; cd06268 114615015622 ligand binding site [chemical binding]; other site 114615015623 shikimate 5-dehydrogenase; Reviewed; Region: PRK12549 114615015624 Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501 114615015625 NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065 114615015626 NAD(P) binding site [chemical binding]; other site 114615015627 shikimate binding site; other site 114615015628 Transcriptional regulator [Transcription]; Region: LysR; COG0583 114615015629 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 114615015630 The C-terminal substrate-domain of LysR-type transcriptional regulators involved in the catabolism of opines and that of related regulators, contains the type 2 periplasmic binding fold; Region: PBP2_LysR_opines_like; cd08415 114615015631 putative dimerization interface [polypeptide binding]; other site 114615015632 AsmA-like C-terminal region; Region: AsmA_2; pfam13502 114615015633 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 114615015634 Cytochrome P450; Region: p450; cl12078 114615015635 oxalate/formate antiporter family transporter; Region: 2A0111; TIGR00890 114615015636 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 114615015637 putative substrate translocation pore; other site 114615015638 The Class III extradiol dioxygenase, 4,5-DOPA Dioxygenase, catalyzes the incorporation of both atoms of molecular oxygen into 4,5-dihydroxy-phenylalanine; Region: 45_DOPA_Dioxygenase; cd07363 114615015639 Catalytic LigB subunit of aromatic ring-opening dioxygenase; Region: LigB; pfam02900 114615015640 putative active site [active] 114615015641 metal binding site [ion binding]; metal-binding site 114615015642 Predicted membrane protein [Function unknown]; Region: COG2259 114615015643 Transcriptional regulator [Transcription]; Region: LysR; COG0583 114615015644 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 114615015645 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 114615015646 putative effector binding pocket; other site 114615015647 dimerization interface [polypeptide binding]; other site 114615015648 Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659 114615015649 Sulfate transporter family; Region: Sulfate_transp; pfam00916 114615015650 Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function; Region: STAS_SulP_like_sulfate_transporter; cd07042 114615015651 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 114615015652 FAD binding domain; Region: FAD_binding_4; pfam01565 114615015653 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 114615015654 active site 114615015655 Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154 114615015656 Amidase; Region: Amidase; pfam01425 114615015657 Uncharacterized distant relative of homeotic protein bithoraxoid [General function prediction only]; Region: COG2018 114615015658 Uncharacterized flavoproteins [Energy production and conversion]; Region: FpaA; COG0426 114615015659 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 114615015660 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 114615015661 ligand binding site [chemical binding]; other site 114615015662 TPR repeat; Region: TPR_11; pfam13414 114615015663 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 114615015664 ligand binding site [chemical binding]; other site 114615015665 Superfamily I DNA and RNA helicases [DNA replication, recombination, and repair]; Region: UvrD; COG0210 114615015666 Part of AAA domain; Region: AAA_19; pfam13245 114615015667 Family description; Region: UvrD_C_2; pfam13538 114615015668 Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885 114615015669 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 114615015670 ligand binding site [chemical binding]; other site 114615015671 Protein of unknown function (DUF962); Region: DUF962; cl01879 114615015672 hopanoid-associated sugar epimerase; Region: HpnA; TIGR03466 114615015673 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 114615015674 NAD(P) binding site [chemical binding]; other site 114615015675 active site 114615015676 Putative protein-S-isoprenylcysteine methyltransferase [Posttranslational modification, protein turnover, chaperones]; Region: STE14; COG2020 114615015677 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 114615015678 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 114615015679 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 114615015680 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 114615015681 Walker A/P-loop; other site 114615015682 ATP binding site [chemical binding]; other site 114615015683 Q-loop/lid; other site 114615015684 ABC transporter signature motif; other site 114615015685 Walker B; other site 114615015686 D-loop; other site 114615015687 H-loop/switch region; other site 114615015688 ABC-2 type transporter; Region: ABC2_membrane; cl17235 114615015689 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 114615015690 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 114615015691 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 114615015692 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 114615015693 TM-ABC transporter signature motif; other site 114615015694 ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129 114615015695 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 114615015696 Walker A/P-loop; other site 114615015697 ATP binding site [chemical binding]; other site 114615015698 Q-loop/lid; other site 114615015699 ABC transporter signature motif; other site 114615015700 Walker B; other site 114615015701 D-loop; other site 114615015702 H-loop/switch region; other site 114615015703 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 114615015704 Periplasmic sugar-binding domain of Thermotoga maritima glucose-binding protein (tmGBP) and its close homologs; Region: PBP1_tmGBP; cd06314 114615015705 Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407 114615015706 ligand binding site [chemical binding]; other site 114615015707 dimerization interface [polypeptide binding]; other site 114615015708 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 114615015709 acyl-CoA synthetase; Validated; Region: PRK05850 114615015710 Fatty acyl-AMP ligase (FAAL); Region: FAAL; cd05931 114615015711 acyl-activating enzyme (AAE) consensus motif; other site 114615015712 active site 114615015713 Predicted membrane protein involved in D-alanine export [Cell envelope biogenesis, outer membrane]; Region: DltB; COG1696 114615015714 The Delta9 Fatty Acid Desaturase (Delta9-FADS)-like CD includes the delta-9 and delta-11 acyl CoA desaturases found in various eukaryotes including vertebrates, insects, higher plants, and fungi. The delta-9 acyl-lipid desaturases are found in a wide...; Region: Delta9-FADS-like; cd03505 114615015715 Fatty acid desaturase; Region: FA_desaturase; pfam00487 114615015716 Di-iron ligands [ion binding]; other site 114615015717 The Delta9 Fatty Acid Desaturase (Delta9-FADS)-like CD includes the delta-9 and delta-11 acyl CoA desaturases found in various eukaryotes including vertebrates, insects, higher plants, and fungi. The delta-9 acyl-lipid desaturases are found in a wide...; Region: Delta9-FADS-like; cd03505 114615015718 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 114615015719 S-adenosylmethionine binding site [chemical binding]; other site 114615015720 Phytoene dehydrogenase and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG1233 114615015721 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 114615015722 Flp pilus assembly protein, pilin Flp [Intracellular trafficking and secretion]; Region: Flp; COG3847 114615015723 Ribosomal protein L11 methylase [Translation, ribosomal structure and biogenesis]; Region: PrmA; COG2264 114615015724 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 114615015725 S-adenosylmethionine binding site [chemical binding]; other site 114615015726 Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321 114615015727 Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006 114615015728 X-Prolyl Aminopeptidase 2. E.C. 3.4.11.9. Also known as X-Pro aminopeptidase, proline aminopeptidase, aminopeptidase P, and aminoacylproline aminopeptidase. Catalyses release of any N-terminal amino acid, including proline, that is linked with proline; Region: APP; cd01085 114615015729 active site 114615015730 bicyclomycin/multidrug efflux system; Provisional; Region: PRK11102 114615015731 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 114615015732 putative substrate translocation pore; other site 114615015733 NAD-dependent DNA ligase LigA; Validated; Region: ligA; PRK07956 114615015734 NAD+ dependent DNA ligase adenylation domain. DNA ligases catalyze the crucial step of joining the breaks in duplex DNA during DNA replication, repair and recombination, utilizing either ATP or NAD(+) as a cofactor, but using the same basic reaction...; Region: LIGANc; cd00114 114615015735 nucleotide binding pocket [chemical binding]; other site 114615015736 K-X-D-G motif; other site 114615015737 catalytic site [active] 114615015738 NAD-dependent DNA ligase OB-fold domain; Region: DNA_ligase_OB; pfam03120 114615015739 Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo...; Region: BRCT; cd00027 114615015740 Dimer interface [polypeptide binding]; other site 114615015741 BRCT sequence motif; other site 114615015742 ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: RecN; COG0497 114615015743 ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241 114615015744 Walker A/P-loop; other site 114615015745 ATP binding site [chemical binding]; other site 114615015746 Q-loop/lid; other site 114615015747 ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241 114615015748 ABC transporter signature motif; other site 114615015749 Walker B; other site 114615015750 D-loop; other site 114615015751 H-loop/switch region; other site 114615015752 outer membrane assembly lipoprotein YfiO; Region: OM_YfiO; TIGR03302 114615015753 Tetratricopeptide repeat; Region: TPR_6; pfam13174 114615015754 UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase; Reviewed; Region: lpxC; PRK13186 114615015755 UDP-3-O-acyl N-acetylglycosamine deacetylase; Region: LpxC; pfam03331 114615015756 Cell division GTPase [Cell division and chromosome partitioning]; Region: FtsZ; COG0206 114615015757 FtsZ is a GTPase that is similar to the eukaryotic tubulins and is essential for cell division in prokaryotes. FtsZ is capable of polymerizing in a GTP-driven process into structures similar to those formed by tubulin. FtsZ forms a ring-shaped septum at...; Region: FtsZ_type1; cd02201 114615015758 nucleotide binding site [chemical binding]; other site 114615015759 SulA interaction site; other site 114615015760 cell division protein FtsZ, alphaProteobacterial C-terminal extension; Region: FtsZ_alphas_C; TIGR03483 114615015761 Cell division ATPase FtsA [Cell division and chromosome partitioning]; Region: ftsA; COG0849 114615015762 Cell division protein FtsA; Region: FtsA; smart00842 114615015763 Cell division protein FtsA; Region: FtsA; pfam14450 114615015764 Cell division septal protein [Cell envelope biogenesis, outer membrane]; Region: FtsQ; COG1589 114615015765 POTRA domain, FtsQ-type; Region: POTRA_1; pfam08478 114615015766 Cell division protein FtsQ; Region: FtsQ; pfam03799 114615015767 D-alanine--D-alanine ligase; Reviewed; Region: ddl; PRK01372 114615015768 D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820 114615015769 ATP-grasp domain; Region: ATP-grasp_4; cl17255 114615015770 UDP-N-acetylenolpyruvoylglucosamine reductase; Provisional; Region: murB; PRK13905 114615015771 FAD binding domain; Region: FAD_binding_4; pfam01565 114615015772 UDP-N-acetylenolpyruvoylglucosamine reductase, C-terminal domain; Region: MurB_C; pfam02873 114615015773 UDP-N-acetylmuramate--L-alanine ligase; Provisional; Region: murC; PRK00421 114615015774 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 114615015775 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 114615015776 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 114615015777 UDP-N-acetylglucosamine:LPS N-acetylglucosamine transferase [Cell envelope biogenesis, outer membrane]; Region: MurG; COG0707 114615015778 MurG is an N-acetylglucosaminyltransferase, the last enzyme involved in the intracellular phase of peptidoglycan biosynthesis. It transfers N-acetyl-D-glucosamine (GlcNAc) from UDP-GlcNAc to the C4 hydroxyl of a lipid-linked N-acetylmuramoyl pentapeptide...; Region: GT1_MurG; cd03785 114615015779 active site 114615015780 homodimer interface [polypeptide binding]; other site 114615015781 cell division protein FtsW; Region: ftsW; TIGR02614 114615015782 UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase; Provisional; Region: murD; PRK01390 114615015783 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 114615015784 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 114615015785 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 114615015786 phospho-N-acetylmuramoyl-pentapeptide-transferase; Provisional; Region: mraY; PRK00108 114615015787 Phospho-N-acetylmuramoyl-pentapeptide-transferase (mraY) is an enzyme responsible for the formation of the first lipid intermediate in the synthesis of bacterial cell wall peptidoglycan. It catalyzes the formation of...; Region: GT_MraY; cd06852 114615015788 Mg++ binding site [ion binding]; other site 114615015789 putative catalytic motif [active] 114615015790 putative substrate binding site [chemical binding]; other site 114615015791 UDP-N-acetylmuramyl pentapeptide synthase [Cell envelope biogenesis, outer membrane]; Region: MurF; COG0770 114615015792 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 114615015793 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 114615015794 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 114615015795 UDP-N-acetylmuramoylalanyl-D-glutamate--2, 6-diaminopimelate ligase; Provisional; Region: murE; PRK00139 114615015796 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 114615015797 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 114615015798 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 114615015799 Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768 114615015800 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 114615015801 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 114615015802 Predicted secreted (periplasmic) protein [Function unknown]; Region: COG5462 114615015803 16S rRNA m(4)C1402 methyltranserfase; Provisional; Region: PRK00050 114615015804 MraW methylase family; Region: Methyltransf_5; cl17771 114615015805 N-acetyl-anhydromuramyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: ampD; COG3023 114615015806 Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583 114615015807 amidase catalytic site [active] 114615015808 Zn binding residues [ion binding]; other site 114615015809 substrate binding site [chemical binding]; other site 114615015810 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 114615015811 Predicted RNA polymerase sigma factor containing a TPR repeat domain [Transcription]; Region: COG4941 114615015812 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3795 114615015813 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 114615015814 ATP-binding cassette domain of the bacterial lipid flippase and related proteins, subfamily C; Region: ABCC_MsbA; cd03251 114615015815 Walker A/P-loop; other site 114615015816 ATP binding site [chemical binding]; other site 114615015817 Q-loop/lid; other site 114615015818 ABC transporter signature motif; other site 114615015819 Walker B; other site 114615015820 D-loop; other site 114615015821 H-loop/switch region; other site 114615015822 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 114615015823 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 114615015824 putative substrate translocation pore; other site 114615015825 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 114615015826 Multidrug resistance efflux pump [Defense mechanisms]; Region: EmrA; COG1566 114615015827 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 114615015828 HlyD family secretion protein; Region: HlyD_3; pfam13437 114615015829 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 114615015830 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 114615015831 AefR-like transcriptional repressor, C-terminal region; Region: TetR_C_7; pfam14246 114615015832 nickel responsive regulator; Provisional; Region: PRK02967 114615015833 Ribbon-helix-helix protein, copG family; Region: RHH_1; pfam01402 114615015834 NikR C terminal nickel binding domain; Region: NikR_C; pfam08753 114615015835 TonB-dependent siderophore receptor; Region: TonB-siderophor; TIGR01783 114615015836 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 114615015837 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3921 114615015838 Extensin-like protein C-terminus; Region: Extensin-like_C; pfam06904 114615015839 Uncharacterized protein conserved in bacteria (DUF2147); Region: DUF2147; pfam09917 114615015840 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054 114615015841 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 114615015842 ATP binding site [chemical binding]; other site 114615015843 Mg2+ binding site [ion binding]; other site 114615015844 G-X-G motif; other site 114615015845 osmolarity response regulator; Provisional; Region: ompR; PRK09468 114615015846 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 114615015847 active site 114615015848 phosphorylation site [posttranslational modification] 114615015849 intermolecular recognition site; other site 114615015850 dimerization interface [polypeptide binding]; other site 114615015851 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 114615015852 DNA binding site [nucleotide binding] 114615015853 efflux transporter, outer membrane factor (OMF) lipoprotein, NodT family; Region: outer_NodT; TIGR01845 114615015854 macrolide transporter subunit MacA; Provisional; Region: PRK11578 114615015855 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 114615015856 Tho complex subunit 7; Region: THOC7; pfam05615 114615015857 HlyD family secretion protein; Region: HlyD_3; pfam13437 114615015858 macrolide transporter ATP-binding /permease protein; Provisional; Region: PRK10535 114615015859 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 114615015860 Walker A/P-loop; other site 114615015861 ATP binding site [chemical binding]; other site 114615015862 Q-loop/lid; other site 114615015863 ABC transporter signature motif; other site 114615015864 Walker B; other site 114615015865 D-loop; other site 114615015866 H-loop/switch region; other site 114615015867 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 114615015868 FtsX-like permease family; Region: FtsX; pfam02687 114615015869 Protein of unknown function (DUF3313); Region: DUF3313; pfam11769 114615015870 EamA-like transporter family; Region: EamA; pfam00892 114615015871 Aerobic-type carbon monoxide dehydrogenase, large subunit CoxL/CutL homologs [Energy production and conversion]; Region: CoxL; COG1529 114615015872 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; smart01008 114615015873 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 114615015874 Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM/CutM homologs [Energy production and conversion]; Region: CoxM; COG1319 114615015875 CO dehydrogenase flavoprotein C-terminal domain; Region: CO_deh_flav_C; smart01092 114615015876 Aerobic-type carbon monoxide dehydrogenase, small subunit CoxS/CutS homologs [Energy production and conversion]; Region: CoxS; COG2080 114615015877 2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_3; pfam13085 114615015878 [2Fe-2S] binding domain; Region: Fer2_2; pfam01799 114615015879 Diadenosine hexaphosphate (Ap6A) hydrolase is a member of the Nudix hydrolase superfamily. Ap6A hydrolase specifically hydrolyzes diadenosine polyphosphates, but not ATP or diadenosine triphosphate, and it generates ATP as the product. Ap6A, the most...; Region: Ap6A_hydrolase; cd03673 114615015880 active site 114615015881 Ap6A binding site [chemical binding]; other site 114615015882 nudix motif; other site 114615015883 metal binding site [ion binding]; metal-binding site 114615015884 Phosphatidylserine decarboxylase; Region: PS_Dcarbxylase; pfam02666 114615015885 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 114615015886 acetylornithine transaminase protein; Provisional; Region: argD; PRK01278 114615015887 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 114615015888 catalytic residue [active] 114615015889 Methyltransferase domain; Region: Methyltransf_31; pfam13847 114615015890 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 114615015891 S-adenosylmethionine binding site [chemical binding]; other site 114615015892 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 114615015893 This family is most closely related to the GT1 family of glycosyltransferases. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can...; Region: GT1_like_2; cd03814 114615015894 Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376 114615015895 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 114615015896 Domain of unknown function (DUF4403); Region: DUF4403; pfam14356 114615015897 Flp pilus assembly protein, pilin Flp [Intracellular trafficking and secretion]; Region: Flp; COG3847 114615015898 Periplasmic binding protein; Region: Peripla_BP_6; pfam13458 114615015899 Periplasmic solute-binding domain of active transport proteins that belong to the type I periplasmic binding fold protein family; Region: PBP1_SBP_like_1; cd06327 114615015900 putative ligand binding site [chemical binding]; other site 114615015901 osmolarity response regulator; Provisional; Region: ompR; PRK09468 114615015902 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 114615015903 active site 114615015904 phosphorylation site [posttranslational modification] 114615015905 intermolecular recognition site; other site 114615015906 dimerization interface [polypeptide binding]; other site 114615015907 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 114615015908 DNA binding site [nucleotide binding] 114615015909 HAMP domain; Region: HAMP; pfam00672 114615015910 dimerization interface [polypeptide binding]; other site 114615015911 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 114615015912 dimer interface [polypeptide binding]; other site 114615015913 phosphorylation site [posttranslational modification] 114615015914 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 114615015915 ATP binding site [chemical binding]; other site 114615015916 Mg2+ binding site [ion binding]; other site 114615015917 G-X-G motif; other site 114615015918 PRC-barrel domain; Region: PRC; pfam05239 114615015919 Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741 114615015920 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 114615015921 N-acetyl-D-glucosamine binding site [chemical binding]; other site 114615015922 catalytic residue [active] 114615015923 glycine oxidase ThiO; Region: thiamin_ThiO; TIGR02352 114615015924 ThiaminS ubiquitin-like sulfur carrier protein; Region: ThiS; cd00565 114615015925 thiS-thiF/thiG interaction site; other site 114615015926 Thiazole synthase (ThiG) is the tetrameric enzyme that is involved in the formation of the thiazole moiety of thiamin pyrophosphate, an essential ubiquitous cofactor that plays an important role in carbohydrate and amino acid metabolism. ThiG catalyzes...; Region: ThiG; cd04728 114615015927 ThiS interaction site; other site 114615015928 putative active site [active] 114615015929 tetramer interface [polypeptide binding]; other site 114615015930 Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5-; Region: TMP_TenI; cd00564 114615015931 thiamine phosphate binding site [chemical binding]; other site 114615015932 active site 114615015933 pyrophosphate binding site [ion binding]; other site 114615015934 thiamine biosynthesis protein ThiC; Provisional; Region: PRK09284 114615015935 ThiC-associated domain; Region: ThiC-associated; pfam13667 114615015936 Thiamine biosynthesis protein ThiC [Coenzyme metabolism]; Region: ThiC; COG0422 114615015937 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 114615015938 homotrimer interaction site [polypeptide binding]; other site 114615015939 putative active site [active] 114615015940 GST_N family, unknown subfamily 4; composed of uncharacterized bacterial proteins with similarity to GSTs. GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of...; Region: GST_N_4; cd03056 114615015941 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 114615015942 putative C-terminal domain interface [polypeptide binding]; other site 114615015943 putative GSH binding site (G-site) [chemical binding]; other site 114615015944 putative dimer interface [polypeptide binding]; other site 114615015945 C-terminal, alpha helical domain of an unknown subfamily 7 of Glutathione S-transferases; Region: GST_C_7; cd03206 114615015946 putative N-terminal domain interface [polypeptide binding]; other site 114615015947 putative dimer interface [polypeptide binding]; other site 114615015948 putative substrate binding pocket (H-site) [chemical binding]; other site 114615015949 G:T/U mismatch specific DNA glcosylase (MUG); Region: UDG_F2_MUG; cd10028 114615015950 active site 114615015951 SUMO-1 interface [polypeptide binding]; other site 114615015952 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 114615015953 Uncharacterized conserved protein (DUF2277); Region: DUF2277; pfam10041 114615015954 hypothetical protein; Provisional; Region: PRK06489 114615015955 homoserine O-acetyltransferase; Provisional; Region: metX; cl17114 114615015956 Predicted membrane protein [Function unknown]; Region: COG4270 114615015957 PPOX class probable FMN-dependent enzyme, DR_2398 family; Region: PPOX_FMN_DR2398; TIGR04025 114615015958 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 114615015959 Membrane Fusion Protein cluster 2 (function with RND porters); Region: 8a0102; TIGR00999 114615015960 HlyD family secretion protein; Region: HlyD_3; pfam13437 114615015961 Putative silver efflux pump [Inorganic ion transport and metabolism]; Region: COG3696 114615015962 Protein of unknown function (DUF3240); Region: DUF3240; pfam11582 114615015963 Bacterioferritin (cytochrome b1) [Inorganic ion transport and metabolism]; Region: Bfr; COG2193 114615015964 Bacterioferritin, ferritin-like diiron-binding domain; Region: Bacterioferritin; cd00907 114615015965 heme binding site [chemical binding]; other site 114615015966 ferroxidase pore; other site 114615015967 ferroxidase diiron center [ion binding]; other site 114615015968 BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324 114615015969 lytic murein transglycosylase; Region: MltB_2; TIGR02283 114615015970 murein hydrolase B; Provisional; Region: PRK10760; cl17906 114615015971 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 114615015972 hypothetical protein; Provisional; Region: PRK05208 114615015973 putative ABC transporter ATP-binding protein; Reviewed; Region: PRK11819 114615015974 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 114615015975 Walker A/P-loop; other site 114615015976 ATP binding site [chemical binding]; other site 114615015977 Q-loop/lid; other site 114615015978 ABC transporter signature motif; other site 114615015979 Walker B; other site 114615015980 D-loop; other site 114615015981 H-loop/switch region; other site 114615015982 ABC transporter; Region: ABC_tran_2; pfam12848 114615015983 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 114615015984 Putative D-3-Phosphoglycerate Dehydrogenases; Region: PGDH_like_1; cd12169 114615015985 Phosphoglycerate dehydrogenase and related dehydrogenases [Amino acid transport and metabolism]; Region: SerA; COG0111 114615015986 dimerization interface [polypeptide binding]; other site 114615015987 NAD binding site [chemical binding]; other site 114615015988 ligand binding site [chemical binding]; other site 114615015989 catalytic site [active] 114615015990 Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376 114615015991 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 114615015992 Rhodanese-related sulfurtransferase [Inorganic ion transport and metabolism]; Region: SseA; COG2897 114615015993 Thiosulfate sulfurtransferase (TST), N-terminal, inactive domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the 1st repeat, which does not contain the catalytically active Cys residue. The role of the 1st repeat is uncertain, but it...; Region: TST_Repeat_1; cd01448 114615015994 active site residue [active] 114615015995 Thiosulfate sulfurtransferase (TST), C-terminal, catalytic domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the second repeat. Only the second repeat contains the catalytically active Cys residue; Region: TST_Repeat_2; cd01449 114615015996 active site residue [active] 114615015997 Polysulfide-sulfurtransferase - Rhodanese Homology Domain. This domain is believed to serve as a polysulfide binding and transferase domain in anaerobic gram-negative bacteria, functioning in oxidative phosphorylation with polysulfide-sulfur as a...; Region: Polysulfide_ST; cd01447 114615015998 active site 114615015999 catalytic residue [active] 114615016000 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3825 114615016001 Predicted membrane protein [Function unknown]; Region: COG2261 114615016002 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 114615016003 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 114615016004 Walker A motif; other site 114615016005 ATP binding site [chemical binding]; other site 114615016006 Walker B motif; other site 114615016007 arginine finger; other site 114615016008 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 114615016009 response regulator; Provisional; Region: PRK13435 114615016010 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cl17736 114615016011 active site 114615016012 phosphorylation site [posttranslational modification] 114615016013 intermolecular recognition site; other site 114615016014 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 114615016015 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 114615016016 dimer interface [polypeptide binding]; other site 114615016017 phosphorylation site [posttranslational modification] 114615016018 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 114615016019 ATP binding site [chemical binding]; other site 114615016020 Mg2+ binding site [ion binding]; other site 114615016021 G-X-G motif; other site 114615016022 Response regulator receiver domain; Region: Response_reg; pfam00072 114615016023 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 114615016024 active site 114615016025 phosphorylation site [posttranslational modification] 114615016026 intermolecular recognition site; other site 114615016027 dimerization interface [polypeptide binding]; other site 114615016028 PAS fold; Region: PAS_3; pfam08447 114615016029 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 114615016030 heme pocket [chemical binding]; other site 114615016031 putative active site [active] 114615016032 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 114615016033 PAS fold; Region: PAS_3; pfam08447 114615016034 putative active site [active] 114615016035 heme pocket [chemical binding]; other site 114615016036 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920 114615016037 HWE histidine kinase; Region: HWE_HK; smart00911 114615016038 HerA helicase [Replication, recombination, and repair]; Region: COG0433 114615016039 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 114615016040 Walker A motif; other site 114615016041 ATP binding site [chemical binding]; other site 114615016042 Walker B motif; other site 114615016043 phospholipase C, phosphocholine-specific, Pseudomonas-type; Region: PC_PLC; TIGR03396 114615016044 Phosphoesterase family; Region: Phosphoesterase; pfam04185 114615016045 Domain of unknown function (DUF756); Region: DUF756; pfam05506 114615016046 Domain of unknown function (DUF756); Region: DUF756; pfam05506 114615016047 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 114615016048 dimer interface [polypeptide binding]; other site 114615016049 phosphorylation site [posttranslational modification] 114615016050 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 114615016051 ATP binding site [chemical binding]; other site 114615016052 Mg2+ binding site [ion binding]; other site 114615016053 G-X-G motif; other site 114615016054 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 114615016055 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 114615016056 active site 114615016057 phosphorylation site [posttranslational modification] 114615016058 intermolecular recognition site; other site 114615016059 dimerization interface [polypeptide binding]; other site 114615016060 OstA-like protein; Region: OstA; cl00844 114615016061 Organic solvent tolerance protein OstA [Cell envelope biogenesis, outer membrane]; Region: Imp; COG1452 114615016062 Organic solvent tolerance protein; Region: OstA_C; pfam04453 114615016063 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 114615016064 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 114615016065 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 114615016066 DNA binding residues [nucleotide binding] 114615016067 dimerization interface [polypeptide binding]; other site 114615016068 ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683 114615016069 Type I periplasmic binding component of ABC (ATPase Binding Cassette)-type transport systems that are predicted to be involved in uptake of amino acids; Region: PBP1_ABC-type_HAAT_like; cd06333 114615016070 putative ligand binding site [chemical binding]; other site 114615016071 choline dehydrogenase; Validated; Region: PRK02106 114615016072 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 114615016073 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 114615016074 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 114615016075 SMP-30/Gluconolaconase/LRE-like region; Region: SGL; pfam08450 114615016076 Strictosidine synthase; Region: Str_synth; pfam03088 114615016077 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 114615016078 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 114615016079 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3708 114615016080 Cupin domain; Region: Cupin_2; cl17218 114615016081 GST_N family, unknown subfamily 1; composed of uncharacterized proteins, predominantly from bacteria, with similarity to GSTs. GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with...; Region: GST_N_1; cd03043 114615016082 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 114615016083 putative C-terminal domain interface [polypeptide binding]; other site 114615016084 putative GSH binding site (G-site) [chemical binding]; other site 114615016085 putative dimer interface [polypeptide binding]; other site 114615016086 C-terminal, alpha helical domain of an unknown subfamily 3 of Glutathione S-transferases; Region: GST_C_3; cd03194 114615016087 putative N-terminal domain interface [polypeptide binding]; other site 114615016088 putative dimer interface [polypeptide binding]; other site 114615016089 putative substrate binding pocket (H-site) [chemical binding]; other site 114615016090 polyhydroxyalkanoate depolymerase, intracellular; Region: PHB_depoly_PhaZ; TIGR01849 114615016091 PHB de-polymerase C-terminus; Region: PHB_depo_C; pfam06850 114615016092 Helix-turn-helix domain; Region: HTH_18; pfam12833 114615016093 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 114615016094 Cupin domain; Region: Cupin_2; pfam07883 114615016095 Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072 114615016096 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 114615016097 Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531 114615016098 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 114615016099 Bacterial periplasmic substrate-binding proteins; Region: PBPb; smart00062 114615016100 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 114615016101 substrate binding pocket [chemical binding]; other site 114615016102 membrane-bound complex binding site; other site 114615016103 hinge residues; other site 114615016104 Cysteine rich repeat; Region: Cys_rich_FGFR; pfam00839 114615016105 The (Largely Gram-negative Bacterial) Hydrophobe/Amphiphile Efflux-1 (HAE1) Family; Region: 2A0602; TIGR00915 114615016106 Bacterial periplasmic substrate-binding proteins; Region: PBPb; smart00062 114615016107 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 114615016108 substrate binding pocket [chemical binding]; other site 114615016109 membrane-bound complex binding site; other site 114615016110 hinge residues; other site 114615016111 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 114615016112 putative substrate translocation pore; other site 114615016113 Major Facilitator Superfamily; Region: MFS_1; pfam07690 114615016114 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 114615016115 Helix-turn-helix domain; Region: HTH_18; pfam12833 114615016116 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 114615016117 Malonyl-CoA decarboxylase (MCD); Region: MCD; pfam05292 114615016118 Putative hydrophobic ligand-binding SRPBCC domain of an uncharacterized subgroup of CalC- and Aha1-like proteins; Region: SRPBCC_CalC_Aha1-like_4; cd08897 114615016119 putative hydrophobic ligand binding site [chemical binding]; other site 114615016120 Protein of unknown function (DUF1043); Region: DUF1043; cl11473 114615016121 Protein of unknown function (DUF3297); Region: DUF3297; pfam11730 114615016122 Glutathione (GSH) peroxidase family; tetrameric selenoenzymes that catalyze the reduction of a variety of hydroperoxides including lipid peroxidases, using GSH as a specific electron donor substrate. GSH peroxidase contains one selenocysteine residue per...; Region: GSH_Peroxidase; cd00340 114615016123 catalytic residues [active] 114615016124 dimer interface [polypeptide binding]; other site 114615016125 amidase; Provisional; Region: PRK07487 114615016126 Amidase; Region: Amidase; cl11426 114615016127 Lactonase, 7-bladed beta-propeller; Region: Lactonase; pfam10282 114615016128 Truncated hemoglobins (trHbs) are a family of oxygen-binding heme proteins found in cyanobacteria, eubacteria, unicellular eukaryotes, and plants. The truncated hemoglobins have a characteristic two-over-two alpha helical folding pattern that is distinct...; Region: Trunc_globin; cd00454 114615016129 apolar tunnel; other site 114615016130 heme binding site [chemical binding]; other site 114615016131 dimerization interface [polypeptide binding]; other site 114615016132 coenzyme PQQ synthesis protein PqqA; Provisional; Region: pqqA; PRK00284 114615016133 coenzyme PQQ biosynthesis protein B; Region: PQQ_syn_pqqB; TIGR02108 114615016134 pyrroloquinoline quinone biosynthesis protein PqqB; Provisional; Region: PRK05184 114615016135 pyrroloquinoline quinone biosynthesis protein PqqC; Provisional; Region: PRK05157 114615016136 Coenzyme PQQ synthesis protein D (PqqD); Region: PqqD; pfam05402 114615016137 pyrroloquinoline quinone biosynthesis protein PqqE; Provisional; Region: PRK05301 114615016138 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 114615016139 FeS/SAM binding site; other site 114615016140 radical SAM additional 4Fe4S-binding SPASM domain; Region: rSAM_more_4Fe4S; TIGR04085 114615016141 proline iminopeptidase, Neisseria-type subfamily; Region: pro_imino_pep_1; TIGR01249 114615016142 Domain of unknown function (DUF4286); Region: DUF4286; pfam14114 114615016143 putative glutamate synthase (NADPH) small subunit; Provisional; Region: PRK12771 114615016144 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 114615016145 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 114615016146 4Fe-4S binding domain; Region: Fer4; pfam00037 114615016147 2-oxoacid:acceptor oxidoreductase, alpha subunit; Region: OAFO_sf; TIGR03710 114615016148 Pyruvate ferredoxin/flavodoxin oxidoreductase; Region: POR; pfam01558 114615016149 Pyrimidine (PYR) binding domain of pyruvate ferredoxin oxidoreductase (PFOR), indolepyruvate ferredoxin oxidoreductase alpha subunit (IOR-alpha), and related proteins; Region: TPP_PYR_PFOR_IOR-alpha_like; cd07034 114615016150 dimer interface [polypeptide binding]; other site 114615016151 PYR/PP interface [polypeptide binding]; other site 114615016152 TPP binding site [chemical binding]; other site 114615016153 substrate binding site [chemical binding]; other site 114615016154 2-oxoglutarate ferredoxin oxidoreductase subunit beta; Validated; Region: PRK05778 114615016155 Thiamine pyrophosphate (TPP family), 2-oxoglutarate ferredoxin oxidoreductase (OGFOR) subfamily, TPP-binding module; OGFOR catalyzes the oxidative decarboxylation of 2-oxo-acids, with ferredoxin acting as an electron acceptor. In the TCA cycle, OGFOR...; Region: TPP_OGFOR; cd03375 114615016156 TPP-binding site [chemical binding]; other site 114615016157 Pyruvate ferredoxin oxidoreductase beta subunit C terminal; Region: PFO_beta_C; pfam12367 114615016158 Protein of unknown function (DUF3754); Region: DUF3754; pfam12576 114615016159 SpoVR family protein; Provisional; Region: PRK11767 114615016160 Uncharacterized conserved protein [Function unknown]; Region: SpoVR; COG2719 114615016161 hypothetical protein; Provisional; Region: PRK05325 114615016162 PrkA family serine protein kinase; Provisional; Region: PRK15455 114615016163 AAA ATPase domain; Region: AAA_16; pfam13191 114615016164 PrkA serine protein kinase C-terminal domain; Region: PrkA; pfam06798 114615016165 bifunctional transaldolase/phosoglucose isomerase; Validated; Region: PRK09533 114615016166 Transaldolase-like proteins from plants and bacteria; Region: Transaldolase_like; cd00955 114615016167 putative active site [active] 114615016168 catalytic residue [active] 114615016169 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the first SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_1; cd05015 114615016170 active site 114615016171 dimer interface [polypeptide binding]; other site 114615016172 SIS_TAL_PGI: Transaldolase (TAL)/ Phosphoglucose isomerase (PGI). This group represents the SIS (Sugar ISomerase) PGI domain, of a multifunctional protein (TAL-PGI ) having both TAL and PGI activities. TAL_PGI contains an N-terminal TAL domain and a...; Region: SIS_TAL_PGI; cd05798 114615016173 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 114615016174 Predicted 6-phosphogluconate dehydrogenase [Carbohydrate transport and metabolism]; Region: Gnd; COG1023 114615016175 glucose-6-phosphate 1-dehydrogenase; Validated; Region: PRK05722 114615016176 Glucose-6-phosphate dehydrogenase, NAD binding domain; Region: G6PD_N; pfam00479 114615016177 Glucose-6-phosphate dehydrogenase, C-terminal domain; Region: G6PD_C; pfam02781 114615016178 6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase [Carbohydrate transport and metabolism]; Region: NagB; COG0363 114615016179 6PGL: 6-Phosphogluconolactonase (6PGL) subfamily; 6PGL catalyzes the second step of the oxidative phase of the pentose phosphate pathway, the hydrolyzation of 6-phosphoglucono-1,5-lactone (delta form) to 6-phosphogluconate. 6PGL is thought to guard...; Region: 6PGL; cd01400 114615016180 putative active site [active] 114615016181 Gluconate kinase (GntK) catalyzes the phosphoryl transfer from ATP to gluconate. The resulting product gluconate-6-phoshate is an important precursor of gluconate metabolism. GntK acts as a dimmer composed of two identical subunits; Region: GntK; cd02021 114615016182 AAA domain; Region: AAA_33; pfam13671 114615016183 ATP-binding site [chemical binding]; other site 114615016184 Gluconate-6-phosphate binding site [chemical binding]; other site 114615016185 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 114615016186 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 114615016187 Glucoamylase and related glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: SGA1; COG3387 114615016188 Glycosyl hydrolases family 15; Region: Glyco_hydro_15; pfam00723 114615016189 4-alpha-glucanotransferase; Provisional; Region: malQ; PRK11052 114615016190 4-alpha-glucanotransferase [Carbohydrate transport and metabolism]; Region: MalQ; COG1640 114615016191 trehalose synthase; Region: treS_nterm; TIGR02456 114615016192 Alpha amylase catalytic domain found in Trehalose synthetase; Region: AmyAc_TreS; cd11334 114615016193 active site 114615016194 catalytic site [active] 114615016195 trehalose synthase-fused probable maltokinase; Region: TreS_Cterm; TIGR02457 114615016196 Uncharacterized protein, probably involved in trehalose biosynthesis [Carbohydrate transport and metabolism]; Region: Ble; COG3281 114615016197 glycogen branching enzyme; Provisional; Region: PRK05402 114615016198 Early set domain associated with the catalytic domain of sugar utilizing enzymes at either the N or C terminus; Region: E_set; cl09101 114615016199 N-terminal Early set domain associated with the catalytic domain of prokaryotic glycogen branching enzyme; Region: E_set_GBE_prok_N; cd02855 114615016200 Alpha amylase catalytic domain found in the Glycogen branching enzyme (also called 1,4-alpha-glucan branching enzyme); Region: AmyAc_Glg_BE; cd11322 114615016201 active site 114615016202 catalytic site [active] 114615016203 Alpha amylase, C-terminal all-beta domain; Region: Alpha-amylase_C; pfam02806 114615016204 glycogen debranching enzyme GlgX; Region: glgX_debranch; TIGR02100 114615016205 N-terminal Early set domain associated with the catalytic domain of Glycogen debranching enzyme and bacterial isoamylase (also called glycogen 6-glucanohydrolase); Region: E_set_GDE_Isoamylase_N; cd02856 114615016206 Alpha amylase catalytic domain found in glycogen debranching enzymes; Region: AmyAc_Glg_debranch; cd11326 114615016207 active site 114615016208 catalytic site [active] 114615016209 N-terminal Early set domain associated with the catalytic domain of Maltooligosyl trehalose trehalohydrolase (also called Glycosyltrehalose trehalohydrolase) and similar proteins; Region: E_set_MTHase_like_N; cd02853 114615016210 malto-oligosyltrehalose trehalohydrolase; Region: trehalose_TreZ; TIGR02402 114615016211 Alpha amylase catalytic domain found in Glycosyltrehalose trehalohydrolase (also called Maltooligosyl trehalose Trehalohydrolase); Region: AmyAc_GTHase; cd11325 114615016212 catalytic site [active] 114615016213 active site 114615016214 Domain of unknown function (DUF3459); Region: DUF3459; pfam11941 114615016215 malto-oligosyltrehalose synthase; Region: trehalose_TreY; TIGR02401 114615016216 Alpha amylase catalytic domain family; Region: AmyAc_family; cl07893 114615016217 Alpha amylase catalytic domain found in maltooligosyl trehalose synthase (MTSase); Region: AmyAc_MTSase; cd11336 114615016218 active site 114615016219 catalytic site [active] 114615016220 Putative polyhydroxyalkanoic acid system protein (PHA_gran_rgn); Region: PHA_gran_rgn; cl09865 114615016221 ATP-dependent DNA ligase; Reviewed; Region: ligD; PRK05972 114615016222 DNA ligase D, 3'-phosphoesterase domain; Region: LigD_PE_dom; TIGR02777 114615016223 Adenylation domain of Mycobacterium tuberculosis LigD and LigC-like ATP-dependent DNA ligases; Region: Adenylation_DNA_ligase_LigD_LigC; cd07906 114615016224 active site 114615016225 DNA binding site [nucleotide binding] 114615016226 The Oligonucleotide/oligosaccharide binding (OB)-fold domain of ATP-dependent DNA ligase LigD is a DNA-binding module that is part of the catalytic core unit; Region: OBF_DNA_ligase_LigD; cd07971 114615016227 DNA binding site [nucleotide binding] 114615016228 PaeLigD_Pol_like: Polymerase (Pol) domain of bacterial LigD proteins similar to Pseudomonas aeruginosa (Pae) LigD. The LigD Pol domain belongs to the archaeal/eukaryal primase (AEP) superfamily. In prokaryotes, LigD along with Ku is required for...; Region: PaeLigD_Pol_like; cd04862 114615016229 nucleotide binding site [chemical binding]; other site 114615016230 Ku protein, prokaryotic; Region: Ku_bact; TIGR02772 114615016231 Ku-core domain, Ku-like subfamily; composed of prokaryotic homologs of the eukaryotic DNA binding protein Ku. The alignment includes the core domain shared by the prokaryotic YkoV-like proteins and the eukaryotic Ku70 and Ku80. The prokaryotic Ku...; Region: KU_like; cd00789 114615016232 putative DNA binding site [nucleotide binding]; other site 114615016233 putative homodimer interface [polypeptide binding]; other site 114615016234 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 114615016235 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 114615016236 active site 114615016237 phosphorylation site [posttranslational modification] 114615016238 intermolecular recognition site; other site 114615016239 dimerization interface [polypeptide binding]; other site 114615016240 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 114615016241 DNA binding site [nucleotide binding] 114615016242 Osmosensitive K+ channel histidine kinase [Signal transduction mechanisms]; Region: KdpD; COG2205 114615016243 Osmosensitive K+ channel His kinase sensor domain; Region: KdpD; pfam02702 114615016244 USP domain is located between the N-terminal sensor domain and C-terminal catalytic domain of this Osmosensitive K+ channel histidine kinase family. The family of KdpD sensor kinase proteins regulates the kdpFABC operon responsible for potassium...; Region: USP_OKCHK; cd01987 114615016245 Ligand Binding Site [chemical binding]; other site 114615016246 Domain of unknown function (DUF4118); Region: DUF4118; pfam13493 114615016247 GAF domain; Region: GAF_3; pfam13492 114615016248 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 114615016249 dimer interface [polypeptide binding]; other site 114615016250 phosphorylation site [posttranslational modification] 114615016251 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 114615016252 ATP binding site [chemical binding]; other site 114615016253 Mg2+ binding site [ion binding]; other site 114615016254 G-X-G motif; other site 114615016255 potassium-transporting ATPase subunit C; Provisional; Region: PRK13999 114615016256 potassium-transporting ATPase subunit B; Provisional; Region: PRK01122 114615016257 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 114615016258 Soluble P-type ATPase [General function prediction only]; Region: COG4087 114615016259 potassium-transporting ATPase subunit A; Provisional; Region: PRK05482 114615016260 potassium-transporting ATPase subunit F; Provisional; Region: PRK14759 114615016261 oxalate/formate antiporter family transporter; Region: 2A0111; TIGR00890 114615016262 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 114615016263 SirA, YedF, and YeeD. Two-layered alpha/beta sandwich domain. SirA (also known as UvrY, and YhhP) belongs to a family of bacterial two-component response regulators that controls secondary metabolism and virulence. The other member of this...; Region: SirA_YedF_YeeD; cd00291 114615016264 CPxP motif; other site 114615016265 Molybdenum is an essential trace element in the form of molybdenum cofactor (Moco) which is associated with the metabolism of nitrogen, carbon and sulfur by redox active enzymes. In E. coli, the synthesis of Moco involves genes from several loci: moa; Region: MobB; cd03116 114615016266 Walker A motif; other site 114615016267 MobA catalyzes the formation of molybdopterin guanine dinucleotide; Region: MobA; cd02503 114615016268 molybdopterin-guanine dinucleotide biosynthesis protein MobA; Reviewed; Region: mobA; PRK00317 114615016269 GTP binding site; other site 114615016270 Co/Zn/Cd efflux system component [Inorganic ion transport and metabolism]; Region: CzcD; COG1230 114615016271 Periplasmic binding protein; Region: Peripla_BP_6; pfam13458 114615016272 Periplasmic solute-binding domain of active transport proteins that belong to the type I periplasmic binding fold protein family; Region: PBP1_SBP_like_1; cd06327 114615016273 putative ligand binding site [chemical binding]; other site 114615016274 Tripartite tricarboxylate transporter family receptor; Region: TctC; cl17792 114615016275 DNA or RNA helicases of superfamily II [Transcription / DNA replication, recombination, and repair]; Region: SSL2; COG1061 114615016276 AE_Prim_S_like: primase domain similar to that found in the small subunit of archaeal and eukaryotic (A/E) DNA primases. The replication machineries of A/Es are distinct from that of bacteria. Primases are DNA-dependent RNA polymerases which synthesis...; Region: AE_Prim_S_like; cl01287 114615016277 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 114615016278 ATP binding site [chemical binding]; other site 114615016279 putative Mg++ binding site [ion binding]; other site 114615016280 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 114615016281 DNA binding residues [nucleotide binding] 114615016282 Nucleotidyl transferase of unknown function (DUF1814); Region: DUF1814; pfam08843 114615016283 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084 114615016284 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 114615016285 Carboxymuconolactone decarboxylase family; Region: CMD; cl00460 114615016286 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 114615016287 Uncharacterized Saccharopolyspora spinosa aldehyde dehydrogenase (AAS00426)-like; Region: ALDH_AAS00426; cd07109 114615016288 NAD(P) binding site [chemical binding]; other site 114615016289 catalytic residues [active] 114615016290 catalytic residues [active] 114615016291 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410 114615016292 ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224 114615016293 Walker A/P-loop; other site 114615016294 ATP binding site [chemical binding]; other site 114615016295 Q-loop/lid; other site 114615016296 ABC transporter signature motif; other site 114615016297 Walker B; other site 114615016298 D-loop; other site 114615016299 H-loop/switch region; other site 114615016300 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 114615016301 Periplasmic binding protein; Region: Peripla_BP_6; pfam13458 114615016302 ABC-type branched-chain amino acid transport system, permease component [Amino acid transport and metabolism]; Region: LivM; COG4177 114615016303 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 114615016304 TM-ABC transporter signature motif; other site 114615016305 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 114615016306 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 114615016307 TM-ABC transporter signature motif; other site 114615016308 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411 114615016309 ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219 114615016310 Walker A/P-loop; other site 114615016311 ATP binding site [chemical binding]; other site 114615016312 Q-loop/lid; other site 114615016313 ABC transporter signature motif; other site 114615016314 Walker B; other site 114615016315 D-loop; other site 114615016316 H-loop/switch region; other site 114615016317 Cache domain; Region: Cache_1; pfam02743 114615016318 PAS fold; Region: PAS_4; pfam08448 114615016319 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 114615016320 putative active site [active] 114615016321 heme pocket [chemical binding]; other site 114615016322 sensor protein ZraS; Provisional; Region: PRK10364 114615016323 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 114615016324 ATP binding site [chemical binding]; other site 114615016325 Mg2+ binding site [ion binding]; other site 114615016326 G-X-G motif; other site 114615016327 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 114615016328 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 114615016329 active site 114615016330 phosphorylation site [posttranslational modification] 114615016331 intermolecular recognition site; other site 114615016332 dimerization interface [polypeptide binding]; other site 114615016333 SAF domain of putative dehydrogenases or oxidoreductases; Region: SAF_DH_OX_like; cd11616 114615016334 gas vesicle protein GvpN; Region: gas_vesic_GvpN; TIGR02640 114615016335 AAA domain (dynein-related subfamily); Region: AAA_5; pfam07728 114615016336 Walker A motif; other site 114615016337 ATP binding site [chemical binding]; other site 114615016338 Walker B motif; other site 114615016339 CbbQ/NirQ/NorQ C-terminal; Region: CbbQ_C; pfam08406 114615016340 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057 114615016341 metal ion-dependent adhesion site (MIDAS); other site 114615016342 UreD urease accessory protein; Region: UreD; pfam01774 114615016343 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 114615016344 urease subunit alpha; Reviewed; Region: ureC; PRK13308 114615016345 Urease alpha-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, fungi and plants. Their primary role is to allow the use of...; Region: Urease_alpha; cd00375 114615016346 subunit interactions [polypeptide binding]; other site 114615016347 active site 114615016348 flap region; other site 114615016349 bifunctional urease subunit gamma/beta; Reviewed; Region: PRK13192 114615016350 Urease gamma-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, archaea, fungi and plants. Their primary role is to allow the use...; Region: Urease_gamma; cd00390 114615016351 alpha-gamma subunit interface [polypeptide binding]; other site 114615016352 beta-gamma subunit interface [polypeptide binding]; other site 114615016353 Urease beta-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, archaea, fungi and plants. Their primary role is to allow the use of...; Region: Urease_beta; cd00407 114615016354 alpha-beta subunit interface [polypeptide binding]; other site 114615016355 Urease accessory protein UreF [Posttranslational modification, protein turnover, chaperones]; Region: UreF; COG0830 114615016356 UreF; Region: UreF; pfam01730 114615016357 urease accessory protein UreE; Provisional; Region: ureE; PRK13261 114615016358 UreE urease accessory protein. UreE is a metallochaperone assisting the insertion of a Ni2+ ion in the active site of urease, an important step in the in vivo assembly of urease, an enzyme that hydrolyses urea into ammonia and carbamic acid. The...; Region: UreE; cl03727 114615016359 dimer interface [polypeptide binding]; other site 114615016360 catalytic residues [active] 114615016361 hypothetical protein; Validated; Region: PRK07581 114615016362 Homoserine acetyltransferase [Amino acid transport and metabolism]; Region: MET2; COG2021 114615016363 Solute carrier families 5 and 6-like; solute binding domain; Region: SLC5-6-like_sbd; cl00456 114615016364 Permease for cytosine/purines, uracil, thiamine, allantoin; Region: Transp_cyt_pur; pfam02133 114615016365 Na binding site [ion binding]; other site 114615016366 acylamide amidohydrolase; Provisional; Region: amiE; PRK13286 114615016367 aliphatic amidases (class 2 nitrilases); Region: aliphatic_amidase; cd07565 114615016368 multimer interface [polypeptide binding]; other site 114615016369 active site 114615016370 catalytic triad [active] 114615016371 dimer interface [polypeptide binding]; other site 114615016372 urea ABC transporter, ATP-binding protein UrtE; Region: urea_trans_UrtE; TIGR03410 114615016373 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 114615016374 Walker A/P-loop; other site 114615016375 ATP binding site [chemical binding]; other site 114615016376 Q-loop/lid; other site 114615016377 ABC transporter signature motif; other site 114615016378 Walker B; other site 114615016379 D-loop; other site 114615016380 H-loop/switch region; other site 114615016381 urea ABC transporter, ATP-binding protein UrtD; Region: urea_trans_UrtD; TIGR03411 114615016382 ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219 114615016383 Walker A/P-loop; other site 114615016384 ATP binding site [chemical binding]; other site 114615016385 Q-loop/lid; other site 114615016386 ABC transporter signature motif; other site 114615016387 Walker B; other site 114615016388 D-loop; other site 114615016389 H-loop/switch region; other site 114615016390 ABC-type branched-chain amino acid transport system, permease component [Amino acid transport and metabolism]; Region: LivM; COG4177 114615016391 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 114615016392 TM-ABC transporter signature motif; other site 114615016393 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 114615016394 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 114615016395 TM-ABC transporter signature motif; other site 114615016396 Periplasmic binding protein; Region: Peripla_BP_6; pfam13458 114615016397 Type I periplasmic components of amide-binding protein (AmiC) and the active transport system for short-chain and urea (FmdDEF); Region: PBP1_AmiC_like; cd06331 114615016398 ligand binding site [chemical binding]; other site 114615016399 Response regulator with putative antiterminator output domain [Signal transduction mechanisms]; Region: AmiR; COG3707 114615016400 ANTAR domain; Region: ANTAR; pfam03861 114615016401 Periplasmic binding protein; Region: Peripla_BP_6; pfam13458 114615016402 Periplasmic binding domain of amidase (AmiC) that belongs to the type I periplasmic binding fold protein family; Region: PBP1_AmiC; cd06357 114615016403 ligand binding site [chemical binding]; other site 114615016404 regulator interaction site; other site 114615016405 Transcriptional regulator containing an amidase domain and an AraC-type DNA-binding HTH domain [Transcription]; Region: COG4977 114615016406 AraC transcriptional regulators having an N-terminal Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GATase1_AraC_ArgR_like; cd03136 114615016407 conserved cys residue [active] 114615016408 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 114615016409 sarcosine oxidase, beta subunit family, heterotetrameric form; Region: soxB; TIGR01373 114615016410 hydroxyglutarate oxidase; Provisional; Region: PRK11728 114615016411 Sarcosine oxidase, delta subunit family; Region: SoxD; pfam04267 114615016412 sarcosine oxidase, alpha subunit family, heterotetrameric form; Region: soxA; TIGR01372 114615016413 2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_4; pfam13510 114615016414 Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669 114615016415 Sarcosine oxidase, gamma subunit family; Region: SoxG; cl01893 114615016416 glutamine synthetase, type III; Region: gln_synth_III; TIGR03105 114615016417 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 114615016418 Glutamate synthase (GltS) FMN-binding domain. GltS is a complex iron-sulfur flavoprotein that catalyzes the reductive synthesis of L-glutamate from 2-oxoglutarate and L-glutamine via intramolecular channelling of ammonia, a reaction in the plant, yeast...; Region: GltS_FMN; cd02808 114615016419 Conserved region in glutamate synthase; Region: Glu_synthase; pfam01645 114615016420 active site 114615016421 FMN binding site [chemical binding]; other site 114615016422 substrate binding site [chemical binding]; other site 114615016423 3Fe-4S cluster binding site [ion binding]; other site 114615016424 GXGXG domain. This domain of unknown function is found at the C-terminus of the large subunit (gltB) of glutamate synthase (GltS), in subunit C of tungsten formylmethanofuran dehydrogenase (FwdC) and in subunit C of molybdenum formylmethanofuran...; Region: GXGXG; cd00504 114615016425 domain_subunit interface; other site 114615016426 Glutamate synthase domain 1 [Amino acid transport and metabolism]; Region: GltB; COG0067 114615016427 Glutamine amidotransferases class-II (GATase). The glutaminase domain catalyzes an amide nitrogen transfer from glutamine to the appropriate substrate. In this process, glutamine is hydrolyzed to glutamic acid and ammonia. This domain is related to...; Region: Gn_AT_II; cl00319 114615016428 Glutamine amidotransferases class-II (Gn-AT)_GlxB-type. GlxB is a glutamine amidotransferase-like protein of unknown function found in bacteria and archaea. GlxB has a structural fold similar to that of other class II glutamine amidotransferases...; Region: GlxB; cd01907 114615016429 putative active site [active] 114615016430 Cupin domain; Region: Cupin_2; pfam07883 114615016431 Methyltransferase domain; Region: Methyltransf_31; pfam13847 114615016432 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 114615016433 S-adenosylmethionine binding site [chemical binding]; other site 114615016434 Predicted tRNA(5-methylaminomethyl-2-thiouridylate) methyltransferase, contains the PP-loop ATPase domain [Translation, ribosomal structure and biogenesis]; Region: TrmU; COG0482 114615016435 tRNA methyl transferase. This family represents tRNA(5-methylaminomethyl-2-thiouridine)-methyltransferase which is involved in the biosynthesis of the modified nucleoside 5-methylaminomethyl-2-thiouridine present in the wobble position of some tRNAs; Region: tRNA_Me_trans; cd01998 114615016436 Ligand Binding Site [chemical binding]; other site 114615016437 Flagellar hook-length control protein FliK; Region: Flg_hook; pfam02120 114615016438 Flagellar hook capping protein - N-terminal region; Region: FlgD; pfam03963 114615016439 FlgD Tudor-like domain; Region: FLgD_tudor; pfam13861 114615016440 Protein of unknown function (DUF1153); Region: DUF1153; pfam06627 114615016441 flagellar MS-ring protein; Reviewed; Region: fliF; PRK06007 114615016442 Secretory protein of YscJ/FliF family; Region: YscJ_FliF; cl01907 114615016443 Flagellar M-ring protein C-terminal; Region: YscJ_FliF_C; pfam08345 114615016444 flagellar motor switch protein G; Validated; Region: fliG; PRK05686 114615016445 MgtE intracellular N domain; Region: MgtE_N; cl15244 114615016446 FliG C-terminal domain; Region: FliG_C; pfam01706 114615016447 flagellar assembly protein H; Validated; Region: fliH; PRK06032 114615016448 Flagellar assembly protein FliH; Region: FliH; pfam02108 114615016449 flagellar motor switch protein; Reviewed; Region: PRK08916 114615016450 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204 114615016451 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 114615016452 Walker A motif; other site 114615016453 ATP binding site [chemical binding]; other site 114615016454 Walker B motif; other site 114615016455 arginine finger; other site 114615016456 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 114615016457 Autotransporter beta-domain; Region: Autotransporter; smart00869 114615016458 Opacity protein and related surface antigens [Cell envelope biogenesis, outer membrane]; Region: COG3637 114615016459 Caspase domain; Region: Peptidase_C14; pfam00656 114615016460 Flavin reductase like domain; Region: Flavin_Reduct; smart00903 114615016461 aliphatic sulfonates transport ATP-binding subunit; Provisional; Region: ssuB; PRK11247 114615016462 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 114615016463 Walker A/P-loop; other site 114615016464 ATP binding site [chemical binding]; other site 114615016465 Q-loop/lid; other site 114615016466 ABC transporter signature motif; other site 114615016467 Walker B; other site 114615016468 D-loop; other site 114615016469 H-loop/switch region; other site 114615016470 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 114615016471 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 114615016472 dimer interface [polypeptide binding]; other site 114615016473 conserved gate region; other site 114615016474 putative PBP binding loops; other site 114615016475 ABC-ATPase subunit interface; other site 114615016476 alkanesulfonate monooxygenase; Provisional; Region: PRK00719 114615016477 Alkanesulfonate monoxygenase is the monoxygenase of a two-component system that catalyzes the conversion of alkanesulfonates to the corresponding aldehyde and sulfite. Alkanesulfonate monoxygenase (SsuD) has an absolute requirement for reduced flavin...; Region: Alkanesulfonate_monoxygenase; cd01094 114615016478 active site 114615016479 dimer interface [polypeptide binding]; other site 114615016480 non-prolyl cis peptide bond; other site 114615016481 insertion regions; other site 114615016482 ABC transporter, substrate-binding protein, aliphatic sulfonates family; Region: SsuA_fam; TIGR01728 114615016483 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 114615016484 substrate binding pocket [chemical binding]; other site 114615016485 membrane-bound complex binding site; other site 114615016486 hinge residues; other site 114615016487 Periplasmic nitrate reductase protein NapE; Region: NapE; pfam06796 114615016488 NapD protein; Region: NapD; pfam03927 114615016489 nitrate reductase catalytic subunit; Provisional; Region: PRK13532 114615016490 Nitrate reductases, NapA (Nitrate-R-NapA), NasA, and NarB catalyze the reduction of nitrate to nitrite. Monomeric Nas is located in the cytoplasm and participates in nitrogen assimilation. Dimeric Nap is located in the periplasm and is coupled to quinol...; Region: MopB_Nitrate-R-NapA-like; cd02754 114615016491 [4Fe-4S] binding site [ion binding]; other site 114615016492 molybdopterin cofactor binding site; other site 114615016493 Nitrate reductases, NapA (Nitrate-R-NapA), NasA, and NarB catalyze the reduction of nitrate to nitrite. Monomeric Nas is located in the cytoplasm and participates in nitrogen assimilation. Dimeric Nap is located in the periplasm and is coupled to quinol...; Region: MopB_CT_Nitrate-R-NapA-like; cd02791 114615016494 molybdopterin cofactor binding site; other site 114615016495 Nitrate reductase cytochrome c-type subunit (NapB); Region: NapB; pfam03892 114615016496 periplasmic nitrate (or nitrite) reductase c-type cytochrome, NapC/NirT family; Region: napC_nirT; TIGR02161 114615016497 NapC/NirT cytochrome c family, N-terminal region; Region: Cytochrom_NNT; pfam03264 114615016498 ATP-dependent exoDNAse (exonuclease V), alpha subunit - helicase superfamily I member [DNA replication, recombination, and repair]; Region: RecD; COG0507 114615016499 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 114615016500 Walker A motif; other site 114615016501 ATP binding site [chemical binding]; other site 114615016502 Walker B motif; other site 114615016503 Family description; Region: UvrD_C_2; pfam13538 114615016504 polyphosphate kinase 2, PA0141 family; Region: PPK2_P_aer; TIGR03707 114615016505 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3666 114615016506 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 114615016507 Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751 114615016508 TPR repeat; Region: TPR_11; pfam13414 114615016509 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 114615016510 binding surface 114615016511 TPR motif; other site 114615016512 TPR repeat; Region: TPR_11; pfam13414 114615016513 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 114615016514 TPR motif; other site 114615016515 binding surface 114615016516 TPR repeat; Region: TPR_11; pfam13414 114615016517 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 114615016518 binding surface 114615016519 TPR motif; other site 114615016520 TPR repeat; Region: TPR_11; pfam13414 114615016521 Tetratricopeptide repeat; Region: TPR_16; pfam13432 114615016522 Caspase domain; Region: Peptidase_C14; pfam00656 114615016523 methionine sulfoxide reductase A; Provisional; Region: PRK13014 114615016524 methionine sulfoxide reductase B; Provisional; Region: PRK00222 114615016525 SelR domain; Region: SelR; pfam01641 114615016526 Domain of unknown function (DUF4112); Region: DUF4112; pfam13430 114615016527 Helix-turn-helix domain; Region: HTH_18; pfam12833 114615016528 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 114615016529 Adenylosuccinate synthetase; Region: Adenylsucc_synt; smart00788 114615016530 Adenylosuccinate synthetase (AdSS) catalyzes the first step in the de novo biosynthesis of AMP. IMP and L-aspartate are conjugated in a two-step reaction accompanied by the hydrolysis of GTP to GDP in the presence of Mg2+. In the first step, the...; Region: AdSS; cd03108 114615016531 GDP-binding site [chemical binding]; other site 114615016532 ACT binding site; other site 114615016533 IMP binding site; other site 114615016534 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 114615016535 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 114615016536 Walker A/P-loop; other site 114615016537 ATP binding site [chemical binding]; other site 114615016538 Q-loop/lid; other site 114615016539 ABC transporter signature motif; other site 114615016540 Walker B; other site 114615016541 D-loop; other site 114615016542 H-loop/switch region; other site 114615016543 ABC-type transport system, involved in lipoprotein release, permease component [Cell envelope biogenesis, outer membrane]; Region: LolE; COG4591 114615016544 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 114615016545 FtsX-like permease family; Region: FtsX; pfam02687 114615016546 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 114615016547 Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404 114615016548 HlyD family secretion protein; Region: HlyD_3; pfam13437 114615016549 Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; smart00831 114615016550 magnesium-translocating P-type ATPase; Region: ATPase-IIIB_Mg; TIGR01524 114615016551 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 114615016552 Soluble P-type ATPase [General function prediction only]; Region: COG4087 114615016553 Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689 114615016554 EamA-like transporter family; Region: EamA; pfam00892 114615016555 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 114615016556 EamA-like transporter family; Region: EamA; pfam00892 114615016557 EamA-like transporter family; Region: EamA; pfam00892 114615016558 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 114615016559 EamA-like transporter family; Region: EamA; pfam00892 114615016560 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4222 114615016561 Cache is an extracellular domain that is predicted to have a role in small-molecule recognition in a wide range of proteins; Region: Cache_2; smart01049 114615016562 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 114615016563 dimerization interface [polypeptide binding]; other site 114615016564 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 114615016565 Methyl-accepting chemotaxis protein (MCP) signalling domain; Region: MCPsignal; pfam00015 114615016566 dimer interface [polypeptide binding]; other site 114615016567 putative CheW interface [polypeptide binding]; other site 114615016568 FtsH Extracellular; Region: FtsH_ext; pfam06480 114615016569 ATP-dependent metalloprotease FtsH; Region: FtsH_fam; TIGR01241 114615016570 Magnesium chelatase, subunit ChlI; Region: Mg_chelatase; pfam01078 114615016571 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 114615016572 Walker A motif; other site 114615016573 ATP binding site [chemical binding]; other site 114615016574 Walker B motif; other site 114615016575 arginine finger; other site 114615016576 Peptidase family M41; Region: Peptidase_M41; pfam01434 114615016577 Periplasmic binding protein; Region: Peripla_BP_6; pfam13458 114615016578 Type I periplasmic binding domain of uncharacterized extracellular ligand-binding proteins; Region: PBP1_STKc_like; cd06326 114615016579 putative ligand binding site [chemical binding]; other site 114615016580 conserved hypothetical protein; Region: TIGR02231 114615016581 N-terminal domain of unknown function (DUF4140); Region: DUF4140; pfam13600 114615016582 Domain of unknown function (DUF4139); Region: DUF4139; pfam13598 114615016583 D-3-phosphoglycerate dehydrogenase; Provisional; Region: PRK13581 114615016584 Phosphoglycerate dehydrogenases, NAD-binding and catalytic domains; Region: PGDH_4; cd12173 114615016585 ligand binding site [chemical binding]; other site 114615016586 NAD binding site [chemical binding]; other site 114615016587 dimerization interface [polypeptide binding]; other site 114615016588 catalytic site [active] 114615016589 C-terminal ACT (regulatory) domain of D-3-phosphoglycerate dehydrogenase (3PGDH); Region: ACT_3PGDH-xct; cd04902 114615016590 putative L-serine binding site [chemical binding]; other site 114615016591 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cd01494 114615016592 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 114615016593 catalytic residue [active] 114615016594 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 114615016595 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 114615016596 active site 114615016597 catalytic tetrad [active] 114615016598 Amidohydrolase; Region: Amidohydro_2; pfam04909 114615016599 Predicted metal-dependent hydrolase of the TIM-barrel fold [General function prediction only]; Region: COG3618 114615016600 active site 114615016601 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 114615016602 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 114615016603 Coenzyme A binding pocket [chemical binding]; other site 114615016604 Outer membrane protein beta-barrel domain; Region: OMP_b-brl; cl17254 114615016605 Opacity protein and related surface antigens [Cell envelope biogenesis, outer membrane]; Region: COG3637 114615016606 phosphoglucosamine mutase; Provisional; Region: glmM; PRK14315 114615016607 GlmM is a bacterial phosphoglucosamine mutase (PNGM) that belongs to the alpha-D-phosphohexomutase superfamily. It is required for the interconversion of glucosamine-6-phosphate and glucosamine-1-phosphate in the biosynthetic pathway of...; Region: GlmM; cd05802 114615016608 active site 114615016609 substrate binding site [chemical binding]; other site 114615016610 metal binding site [ion binding]; metal-binding site 114615016611 L-lactate dehydrogenase; Provisional; Region: lldD; PRK11197 114615016612 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 114615016613 phosphate binding site [ion binding]; other site 114615016614 shikimate 5-dehydrogenase; Reviewed; Region: aroE; PRK00258 114615016615 Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501 114615016616 NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065 114615016617 shikimate binding site; other site 114615016618 NAD(P) binding site [chemical binding]; other site 114615016619 Protein of unknown function (DUF1275); Region: DUF1275; pfam06912 114615016620 putative transporter; Provisional; Region: PRK11660 114615016621 Sulfate transporter N-terminal domain with GLY motif; Region: Sulfate_tra_GLY; pfam13792 114615016622 Sulfate transporter family; Region: Sulfate_transp; pfam00916 114615016623 Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function; Region: STAS_SulP_like_sulfate_transporter; cd07042 114615016624 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 114615016625 non-specific DNA binding site [nucleotide binding]; other site 114615016626 salt bridge; other site 114615016627 sequence-specific DNA binding site [nucleotide binding]; other site 114615016628 Domain of unknown function (DUF4118); Region: DUF4118; pfam13493 114615016629 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920 114615016630 Histidine kinase; Region: HisKA_2; pfam07568 114615016631 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 114615016632 ATP binding site [chemical binding]; other site 114615016633 Mg2+ binding site [ion binding]; other site 114615016634 G-X-G motif; other site 114615016635 haemagglutination activity domain; Region: Haemagg_act; smart00912 114615016636 Autotransporter-associated beta strand repeat; Region: Autotrns_rpt; pfam12951 114615016637 Autotransporter-associated beta strand repeat; Region: Autotrns_rpt; pfam12951 114615016638 Autotransporter-associated beta strand repeat; Region: Autotrns_rpt; pfam12951 114615016639 Autotransporter-associated beta strand repeat; Region: Autotrns_rpt; pfam12951 114615016640 filamentous hemagglutinin family N-terminal domain; Region: adhes_NPXG; TIGR01901 114615016641 Hemolysin activation/secretion protein [Intracellular trafficking and secretion]; Region: FhaC; COG2831 114615016642 Haemolysin secretion/activation protein ShlB/FhaC/HecB; Region: ShlB; pfam03865 114615016643 Elongation factor G (EF-G) family; Region: EF-G_bact; cd04170 114615016644 elongation factor G; Reviewed; Region: PRK12740 114615016645 G1 box; other site 114615016646 putative GEF interaction site [polypeptide binding]; other site 114615016647 GTP/Mg2+ binding site [chemical binding]; other site 114615016648 Switch I region; other site 114615016649 G2 box; other site 114615016650 G3 box; other site 114615016651 Switch II region; other site 114615016652 G4 box; other site 114615016653 G5 box; other site 114615016654 EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088 114615016655 EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434 114615016656 EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G. Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713 114615016657 Protein of unknown function (DUF992); Region: DUF992; pfam06186 114615016658 Protein of unknown function (DUF992); Region: DUF992; pfam06186 114615016659 aspartate aminotransferase; Provisional; Region: PRK05764 114615016660 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 114615016661 pyridoxal 5'-phosphate binding site [chemical binding]; other site 114615016662 homodimer interface [polypeptide binding]; other site 114615016663 catalytic residue [active] 114615016664 Protein of unknown function (DUF2029); Region: DUF2029; pfam09594 114615016665 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 114615016666 GST_N family, unknown subfamily 4; composed of uncharacterized bacterial proteins with similarity to GSTs. GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of...; Region: GST_N_4; cd03056 114615016667 putative C-terminal domain interface [polypeptide binding]; other site 114615016668 putative GSH binding site (G-site) [chemical binding]; other site 114615016669 putative dimer interface [polypeptide binding]; other site 114615016670 C-terminal, alpha helical domain of the Glutathione S-transferase family; Region: GST_C_family; cl02776 114615016671 N-terminal domain interface [polypeptide binding]; other site 114615016672 dimer interface [polypeptide binding]; other site 114615016673 substrate binding pocket (H-site) [chemical binding]; other site 114615016674 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 114615016675 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 114615016676 Coenzyme A binding pocket [chemical binding]; other site 114615016677 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 114615016678 Domain of unknown function DUF20; Region: UPF0118; pfam01594 114615016679 Uncharacterized enzyme involved in biosynthesis of extracellular polysaccharides [General function prediction only]; Region: COG2329 114615016680 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4102 114615016681 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5267 114615016682 Cysteine-rich CWC; Region: Cys_rich_CWC; pfam14375 114615016683 Predicted phosphatase/phosphohexomutase [General function prediction only]; Region: COG0637 114615016684 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 114615016685 motif II; other site 114615016686 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 114615016687 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 114615016688 enoyl-CoA hydratase; Provisional; Region: PRK05980 114615016689 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 114615016690 substrate binding site [chemical binding]; other site 114615016691 oxyanion hole (OAH) forming residues; other site 114615016692 trimer interface [polypeptide binding]; other site 114615016693 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 114615016694 GST_N family, Beta etherase LigE subfamily; composed of proteins similar to Sphingomonas paucimobilis beta etherase, LigE, a GST-like protein that catalyzes the cleavage of the beta-aryl ether linkages present in low-moleculer weight lignins using GSH as...; Region: GST_N_etherase_LigE; cd03038 114615016695 putative C-terminal domain interface [polypeptide binding]; other site 114615016696 putative GSH binding site (G-site) [chemical binding]; other site 114615016697 putative dimer interface [polypeptide binding]; other site 114615016698 C-terminal, alpha helical domain of Beta etherase LigE; Region: GST_C_etherase_LigE; cd03202 114615016699 putative dimer interface [polypeptide binding]; other site 114615016700 putative N-terminal domain interface [polypeptide binding]; other site 114615016701 putative substrate binding pocket (H-site) [chemical binding]; other site 114615016702 DNA-binding transcriptional activator GcvA; Provisional; Region: PRK11139 114615016703 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 114615016704 The C-terminal substrate domain of LysR-type GcdR, TrPI, HvR and beta-lactamase regulators, and that of other closely related homologs; contains the type 2 periplasmic binding fold; Region: PBP2_GcdR_TrpI_HvrB_AmpR_like; cd08432 114615016705 dimerization interface [polypeptide binding]; other site 114615016706 substrate binding pocket [chemical binding]; other site 114615016707 excinuclease ABC subunit B; Provisional; Region: PRK05298 114615016708 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 114615016709 ATP binding site [chemical binding]; other site 114615016710 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 114615016711 nucleotide binding region [chemical binding]; other site 114615016712 ATP-binding site [chemical binding]; other site 114615016713 Ultra-violet resistance protein B; Region: UvrB; pfam12344 114615016714 UvrB/uvrC motif; Region: UVR; pfam02151 114615016715 SEC-C motif; Region: SEC-C; pfam02810 114615016716 ribose-phosphate pyrophosphokinase; Provisional; Region: PRK01259 114615016717 N-terminal domain of ribose phosphate pyrophosphokinase; Region: Pribosyltran_N; pfam13793 114615016718 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 114615016719 active site 114615016720 Multicopper polyphenol oxidase (laccase) [Secondary metabolites biosynthesis, transport and catabolism]; Region: yfiH; COG1496 114615016721 Multi-copper polyphenol oxidoreductase laccase; Region: Cu-oxidase_4; pfam02578 114615016722 Uncharacterized conserved protein [Function unknown]; Region: COG1565 114615016723 Coenzyme B12-dependent glutamate mutase epsilon subunit-like family; contains proteins similar to Clostridium cochlearium glutamate mutase (Glm) and Streptomyces tendae Tu901 NikV. Glm catalyzes a carbon-skeleton rearrangement of L-glutamate to...; Region: Glm_e; cl02025 114615016724 prolipoprotein diacylglyceryl transferase; Reviewed; Region: PRK00052 114615016725 Membrane fusogenic activity; Region: BMFP; pfam04380 114615016726 50S ribosomal protein L25/general stress protein Ctc; Reviewed; Region: PRK05618 114615016727 Ribosomal L25/TL5/CTC N-terminal 5S rRNA binding domain; Region: Ribosomal_L25_TL5_CTC; cd00495 114615016728 CTC domain interface [polypeptide binding]; other site 114615016729 L16 interface [polypeptide binding]; other site 114615016730 Peptidyl-tRNA hydrolase (PTH) is a monomeric protein that cleaves the ester bond linking the nascent peptide and tRNA when peptidyl-tRNA is released prematurely from the ribosome. This ensures the recycling of peptidyl-tRNAs into tRNAs produced through...; Region: PTH; cd00462 114615016731 putative active site [active] 114615016732 catalytic residue [active] 114615016733 GTP-binding protein YchF; Reviewed; Region: PRK09601 114615016734 YchF GTPase; Region: YchF; cd01900 114615016735 G1 box; other site 114615016736 GTP/Mg2+ binding site [chemical binding]; other site 114615016737 Switch I region; other site 114615016738 G2 box; other site 114615016739 Switch II region; other site 114615016740 G3 box; other site 114615016741 G4 box; other site 114615016742 G5 box; other site 114615016743 TGS_YchF_C: This subfamily represents TGS domain-containing YchF GTP-binding protein, a universally conserved GTPase whose function is unknown. The N-terminal domain of the YchF protein belongs to the Obg-like family of GTPases, and some members of the...; Region: TGS_YchF_C; cd04867 114615016744 Domain of unknown function (DUF4282); Region: DUF4282; pfam14110 114615016745 YdeM is a Bacillus subtilis protein that belongs to a family of prokaryotic proteins of unkown function. YdeM has sequence similarity to the hot-dog fold of (R)-specific enoyl-CoA hydratase. Other enzymes with this fold include the peroxisomal...; Region: YdeM; cd03454 114615016746 putative active site [active] 114615016747 putative catalytic site [active] 114615016748 YdeM is a Bacillus subtilis protein that belongs to a family of prokaryotic proteins of unkown function. YdeM has sequence similarity to the hot-dog fold of (R)-specific enoyl-CoA hydratase. Other enzymes with this fold include the peroxisomal...; Region: YdeM; cd03454 114615016749 putative active site [active] 114615016750 putative catalytic site [active] 114615016751 SnoaL-like domain; Region: SnoaL_2; pfam12680 114615016752 Uncharacterized protein involved in benzoate metabolism [Secondary metabolites biosynthesis, transport, and catabolism]; Region: BenE; COG3135 114615016753 benzoate transporter; Region: benE; TIGR00843 114615016754 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 114615016755 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 114615016756 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 114615016757 dimer interface [polypeptide binding]; other site 114615016758 conserved gate region; other site 114615016759 putative PBP binding loops; other site 114615016760 ABC-ATPase subunit interface; other site 114615016761 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 114615016762 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 114615016763 dimer interface [polypeptide binding]; other site 114615016764 conserved gate region; other site 114615016765 putative PBP binding loops; other site 114615016766 ABC-ATPase subunit interface; other site 114615016767 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 114615016768 GAF domain; Region: GAF; pfam01590 114615016769 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920 114615016770 HWE histidine kinase; Region: HWE_HK; smart00911 114615016771 Xanthine and CO dehydrogenases maturation factor, XdhC/CoxF family [Posttranslational modification, protein turnover, chaperones]; Region: XdhC; COG1975 114615016772 XdhC and CoxI family; Region: XdhC_CoxI; pfam02625 114615016773 XdhC Rossmann domain; Region: XdhC_C; pfam13478 114615016774 Protein containing von Willebrand factor type A (vWA) domain [General function prediction only]; Region: CoxE; COG3552 114615016775 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198 114615016776 metal ion-dependent adhesion site (MIDAS); other site 114615016777 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 114615016778 gas vesicle protein GvpN; Region: gas_vesic_GvpN; TIGR02640 114615016779 Walker A motif; other site 114615016780 ATP binding site [chemical binding]; other site 114615016781 Walker B motif; other site 114615016782 carbon-monoxide dehydrogenase, large subunit; Region: CO_dehy_Mo_lg; TIGR02416 114615016783 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; pfam01315 114615016784 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 114615016785 Aerobic-type carbon monoxide dehydrogenase, small subunit CoxS/CutS homologs [Energy production and conversion]; Region: CoxS; COG2080 114615016786 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 114615016787 catalytic loop [active] 114615016788 iron binding site [ion binding]; other site 114615016789 [2Fe-2S] binding domain; Region: Fer2_2; pfam01799 114615016790 Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM/CutM homologs [Energy production and conversion]; Region: CoxM; COG1319 114615016791 FAD binding domain; Region: FAD_binding_4; pfam01565 114615016792 CO dehydrogenase flavoprotein C-terminal domain; Region: CO_deh_flav_C; pfam03450 114615016793 MHYT domain (predicted integral membrane sensor domain) [Signal transduction mechanisms]; Region: COG3300 114615016794 Bacterial signalling protein N terminal repeat; Region: MHYT; pfam03707 114615016795 Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms]; Region: LytT; COG3279 114615016796 LytTr DNA-binding domain; Region: LytTR; smart00850 114615016797 riboflavin synthase subunit beta; Provisional; Region: PRK12419 114615016798 active site 114615016799 homopentamer interface [polypeptide binding]; other site 114615016800 Putative bacterial sensory transduction regulator; Region: YbjN; cl15834 114615016801 pyrroline-5-carboxylate reductase; Reviewed; Region: PRK11880 114615016802 NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; cl17232 114615016803 Predicted thioesterase [General function prediction only]; Region: COG5496 114615016804 4-Oxalocrotonate Tautomerase: Catalyzes the isomerization of unsaturated ketones. The structure is a homohexamer that is arranged as a trimer of dimers. The hexamer contains six active sites, each formed by residues from three monomers, two from one...; Region: 4Oxalocrotonate_Tautomerase; cl00235 114615016805 active site 1 [active] 114615016806 dimer interface [polypeptide binding]; other site 114615016807 hexamer interface [polypeptide binding]; other site 114615016808 active site 2 [active] 114615016809 histidyl-tRNA synthetase; Region: hisS; TIGR00442 114615016810 Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for...; Region: HisRS-like_core; cd00773 114615016811 dimer interface [polypeptide binding]; other site 114615016812 motif 1; other site 114615016813 motif 2; other site 114615016814 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 114615016815 active site 114615016816 motif 3; other site 114615016817 HisRS Histidyl-anticodon binding domain. HisRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: HisRS_anticodon; cd00859 114615016818 anticodon binding site; other site 114615016819 branched-chain amino acid aminotransferase; Provisional; Region: PRK13357 114615016820 BCAT_beta_family: Branched-chain aminotransferase catalyses the transamination of the branched-chain amino acids leusine, isoleucine and valine to their respective alpha-keto acids, alpha-ketoisocaproate, alpha-keto-beta-methylvalerate and...; Region: BCAT_beta_family; cd01557 114615016821 homodimer interface [polypeptide binding]; other site 114615016822 substrate-cofactor binding pocket; other site 114615016823 catalytic residue [active] 114615016824 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 114615016825 MarR family; Region: MarR_2; pfam12802 114615016826 heavy metal response regulator; Region: cztR_silR_copR; TIGR01387 114615016827 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 114615016828 active site 114615016829 phosphorylation site [posttranslational modification] 114615016830 intermolecular recognition site; other site 114615016831 dimerization interface [polypeptide binding]; other site 114615016832 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 114615016833 DNA binding site [nucleotide binding] 114615016834 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054 114615016835 dimerization interface [polypeptide binding]; other site 114615016836 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 114615016837 dimer interface [polypeptide binding]; other site 114615016838 phosphorylation site [posttranslational modification] 114615016839 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 114615016840 ATP binding site [chemical binding]; other site 114615016841 Mg2+ binding site [ion binding]; other site 114615016842 G-X-G motif; other site 114615016843 2,3-dihydroxybiphenyl 1,2-dioxygenase; Region: 23dbph12diox; TIGR03213 114615016844 N-terminal domain of 2,3-dihydroxybiphenyl 1,2-dioxygenase (BphC, EC 1.13.11.39) 1 from Rhodococcus globerulus P6 (BphC1-RGP6) and similar proteins; Region: BphC1-RGP6_N_like; cd07252 114615016845 C-terminal domain of 2,3-dihydroxybiphenyl 1,2-dioxygenase (BphC, EC 1.13.11.39) 1 from Rhodococcus globerulus P6 (BphC1-RGP6) and similar proteins; Region: BphC1-RGP6_C_like; cd07237 114615016846 active site 114615016847 Fe binding site [ion binding]; other site 114615016848 helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346 114615016849 Transcriptional regulator [Transcription]; Region: IclR; COG1414 114615016850 Bacterial transcriptional regulator; Region: IclR; pfam01614 114615016851 3-(3-hydroxyphenyl)propionate hydroxylase; Validated; Region: mhpA; PRK06183 114615016852 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 114615016853 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 114615016854 2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179 114615016855 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557 114615016856 Periplasmic binding protein; Region: Peripla_BP_6; pfam13458 114615016857 Periplasmic solute-binding domain of active transport proteins that belong to the type I periplasmic binding fold protein family; Region: PBP1_SBP_like_1; cd06327 114615016858 putative ligand binding site [chemical binding]; other site 114615016859 Protein of unknown function (DUF3617); Region: DUF3617; pfam12276 114615016860 Ribonuclease T2 (RNase T2) is a widespread family of secreted RNases found in every organism examined thus far. This family includes RNase Rh, RNase MC1, RNase LE, and self-incompatibility RNases (S-RNases). Plant T2 RNases are expressed during leaf...; Region: RNase_T2_prok; cd01062 114615016861 B1 nucleotide binding pocket [chemical binding]; other site 114615016862 B2 nucleotide binding pocket [chemical binding]; other site 114615016863 CAS motifs; other site 114615016864 active site 114615016865 Protein involved in catabolism of external DNA [General function prediction only]; Region: ComJ; COG2961 114615016866 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 114615016867 DNA-binding site [nucleotide binding]; DNA binding site 114615016868 RNA-binding motif; other site 114615016869 Opacity protein and related surface antigens [Cell envelope biogenesis, outer membrane]; Region: COG3637 114615016870 excinuclease ABC subunit C; Validated; Region: uvrC; PRK00558 114615016871 Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434 114615016872 GIY-YIG motif/motif A; other site 114615016873 active site 114615016874 catalytic site [active] 114615016875 putative DNA binding site [nucleotide binding]; other site 114615016876 metal binding site [ion binding]; metal-binding site 114615016877 UvrB/uvrC motif; Region: UVR; pfam02151 114615016878 UvrC Helix-hairpin-helix N-terminal; Region: UvrC_HhH_N; pfam08459 114615016879 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cl14786 114615016880 GIY-YIG domain of LuxR and ArsR family transcriptional regulators, and uncharacterized hypothetical proteins found in bacteria; Region: GIY-YIG_LuxR_like; cd10451 114615016881 GIY-YIG motif/motif A; other site 114615016882 Phosphatidylglycerophosphate synthase [Lipid metabolism]; Region: PgsA; COG0558 114615016883 Ubiquitin domain of MoaD-like proteins; Region: MoaD; cd00754 114615016884 MoaE interaction surface [polypeptide binding]; other site 114615016885 MoeB interaction surface [polypeptide binding]; other site 114615016886 thiocarboxylated glycine; other site 114615016887 MoaE family. Members of this family are involved in biosynthesis of the molybdenum cofactor (Moco), an essential cofactor for a diverse group of redox enzymes. Moco biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoaE; cd00756 114615016888 MoaE homodimer interface [polypeptide binding]; other site 114615016889 MoaD interaction [polypeptide binding]; other site 114615016890 active site residues [active] 114615016891 HemK family putative methylases; Region: hemK_fam; TIGR00536 114615016892 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 114615016893 S-adenosylmethionine binding site [chemical binding]; other site 114615016894 beta alanine--pyruvate transaminase; Provisional; Region: PRK09221 114615016895 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 114615016896 inhibitor-cofactor binding pocket; inhibition site 114615016897 pyridoxal 5'-phosphate binding site [chemical binding]; other site 114615016898 catalytic residue [active] 114615016899 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 114615016900 Predicted sugar phosphatases of the HAD superfamily [Carbohydrate transport and metabolism]; Region: NagD; COG0647 114615016901 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 114615016902 active site 114615016903 motif I; other site 114615016904 motif II; other site 114615016905 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 114615016906 chemotaxis regulatory protein CheY; Provisional; Region: PRK10610 114615016907 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 114615016908 active site 114615016909 phosphorylation site [posttranslational modification] 114615016910 intermolecular recognition site; other site 114615016911 dimerization interface [polypeptide binding]; other site 114615016912 bifunctional riboflavin kinase/FMN adenylyltransferase; Reviewed; Region: PRK05627 114615016913 FAD synthetase, N-terminal domain of the bifunctional enzyme; Region: FAD_synthetase_N; cd02064 114615016914 active site 114615016915 Riboflavin kinase; Region: Flavokinase; pfam01687 114615016916 isoleucyl-tRNA synthetase; Provisional; Region: ileS; PRK13804 114615016917 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 114615016918 active site 114615016919 HIGH motif; other site 114615016920 nucleotide binding site [chemical binding]; other site 114615016921 catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818 114615016922 active site 114615016923 KMSKS motif; other site 114615016924 Anticodon-binding domain of bacterial and eukaryotic mitochondrial isoleucyl tRNA synthetases; Region: Anticodon_Ia_Ile_BEm; cd07960 114615016925 tRNA binding surface [nucleotide binding]; other site 114615016926 anticodon binding site; other site 114615016927 lipoprotein signal peptidase; Provisional; Region: PRK14796 114615016928 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 114615016929 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 114615016930 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 114615016931 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 114615016932 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 114615016933 hypothetical protein; Provisional; Region: PRK09256 114615016934 Protein chain release factor B [Translation, ribosomal structure and biogenesis]; Region: PrfB; COG1186 114615016935 Cytochrome c; Region: Cytochrom_C; cl11414 114615016936 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 114615016937 Glyoxalase I catalyzes the isomerization of the hemithioacetal, formed by a 2-oxoaldehyde and glutathione, to S-D-lactoylglutathione; Region: Glyoxalase_I; cd07233 114615016938 active site 114615016939 dimer interface [polypeptide binding]; other site 114615016940 metal binding site [ion binding]; metal-binding site 114615016941 glutathione binding site [chemical binding]; other site 114615016942 Gluconate 2-dehydrogenase subunit 3; Region: Gluconate_2-dh3; pfam13618 114615016943 Choline dehydrogenase and related flavoproteins [Amino acid transport and metabolism]; Region: BetA; COG2303 114615016944 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 114615016945 Uncharacterized protein related to arylsulfate sulfotransferase involved in siderophore biosynthesis [General function prediction only]; Region: COG4321 114615016946 DNA mismatch repair protein; Reviewed; Region: mutL; PRK00095 114615016947 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 114615016948 ATP binding site [chemical binding]; other site 114615016949 Mg2+ binding site [ion binding]; other site 114615016950 G-X-G motif; other site 114615016951 MutL_Trans: transducer domain, having a ribosomal S5 domain 2-like fold, conserved in the C-terminal domain of DNA mismatch repair (MutL/MLH1/PMS2) family. This transducer domain is homologous to the second domain of the DNA gyrase B subunit, which is...; Region: MutL_Trans; cd00782 114615016952 ATP binding site [chemical binding]; other site 114615016953 MutL C terminal dimerisation domain; Region: MutL_C; pfam08676 114615016954 N6-adenine-specific methylase [DNA replication, recombination, and repair]; Region: COG0742 114615016955 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 114615016956 S-adenosylmethionine binding site [chemical binding]; other site 114615016957 16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187 114615016958 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 114615016959 RNA binding surface [nucleotide binding]; other site 114615016960 Pseudouridine synthases catalyze the isomerization of specific uridines in an RNA molecule to pseudouridines (5-ribosyluracil, psi); Region: PseudoU_synth; cl00130 114615016961 active site 114615016962 Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285 114615016963 nucleoside/Zn binding site; other site 114615016964 dimer interface [polypeptide binding]; other site 114615016965 catalytic motif [active] 114615016966 alpha/beta hydrolase fold; Region: Abhydrolase_1; pfam00561 114615016967 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 114615016968 Cytochrome P450; Region: p450; cl12078 114615016969 Methyltransferase domain; Region: Methyltransf_12; pfam08242 114615016970 Double zinc ribbon; Region: DZR; pfam12773 114615016971 zinc-ribbon domain; Region: zf-ribbon_3; pfam13248 114615016972 Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114 114615016973 cyclase homology domain; Region: CHD; cd07302 114615016974 nucleotidyl binding site; other site 114615016975 metal binding site [ion binding]; metal-binding site 114615016976 dimer interface [polypeptide binding]; other site 114615016977 Predicted ATPase [General function prediction only]; Region: COG3899 114615016978 AAA ATPase domain; Region: AAA_16; pfam13191 114615016979 phosphoribosylamine--glycine ligase; Provisional; Region: PRK00885 114615016980 Phosphoribosylglycinamide synthetase, N domain; Region: GARS_N; pfam02844 114615016981 Phosphoribosylglycinamide synthetase, ATP-grasp (A) domain; Region: GARS_A; pfam01071 114615016982 Phosphoribosylglycinamide synthetase, C domain; Region: GARS_C; pfam02843 114615016983 Winged helix DNA-binding domain; Region: HTH_34; pfam13601 114615016984 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 114615016985 exodeoxyribonuclease VII large subunit; Reviewed; Region: xseA; PRK00286 114615016986 ExoVII_LU_OBF: A subfamily of OB folds corresponding to the N-terminal OB-fold domain of Escherichia coli exodeoxyribonuclease VII (ExoVII) large subunit. E. coli ExoVII is composed of two non-identical subunits. E. coli ExoVII is a...; Region: ExoVII_LU_OBF; cd04489 114615016987 generic binding surface II; other site 114615016988 generic binding surface I; other site 114615016989 Dienelactone hydrolase and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG0412 114615016990 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 114615016991 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3908 114615016992 tetraacyldisaccharide 4'-kinase; Reviewed; Region: lpxK; PRK00652 114615016993 Tetraacyldisaccharide-1-P 4'-kinase [Cell envelope biogenesis, outer membrane]; Region: LpxK; COG1663 114615016994 3-deoxy-D-manno-octulosonic-acid transferase; Reviewed; Region: PRK05749 114615016995 3-Deoxy-D-manno-octulosonic-acid transferase (kdotransferase); Region: Glycos_transf_N; pfam04413 114615016996 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: DUF374; Region: LPLAT_DUF374-like; cd07983 114615016997 putative acyl-acceptor binding pocket; other site 114615016998 Domain of unknown function (DUF4170); Region: DUF4170; pfam13773 114615016999 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483 114615017000 CysQ, a 3'-Phosphoadenosine-5'-phosphosulfate (PAPS) 3'-phosphatase, is a bacterial member of the inositol monophosphatase family. It has been proposed that CysQ helps control intracellular levels of PAPS, which is an intermediate in...; Region: CysQ; cd01638 114615017001 active site 114615017002 Predicted Zn-dependent proteases and their inactivated homologs [General function prediction only]; Region: TldD; COG0312 114615017003 4-hydroxybenzoate polyprenyltransferase; Reviewed; Region: ubiA; PRK12878 114615017004 UbiA prenyltransferase family; Region: UbiA; pfam01040 114615017005 16S ribosomal RNA methyltransferase RsmE; Provisional; Region: PRK11713 114615017006 RNA methyltransferase, RsmE family; Region: TIGR00046 114615017007 ATP phosphoribosyltransferase regulatory subunit; Provisional; Region: hisZ; PRK12295 114615017008 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 114615017009 motif 1; other site 114615017010 dimer interface [polypeptide binding]; other site 114615017011 active site 114615017012 motif 2; other site 114615017013 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 114615017014 active site 114615017015 motif 3; other site 114615017016 ATP phosphoribosyltransferase; Reviewed; Region: hisG; PRK00489 114615017017 ATP phosphoribosyltransferase catalytic subunit; Provisional; Region: hisG; PRK13583 114615017018 undecaprenyl phosphate 4-deoxy-4-formamido-L-arabinose transferase; Provisional; Region: PRK10714 114615017019 Bacterial DPM1_like enzymes are related to eukaryotic DPM1; Region: DPM1_like_bac; cd04187 114615017020 Ligand binding site; other site 114615017021 Putative Catalytic site; other site 114615017022 DXD motif; other site 114615017023 uncharacterized YdjC-like family proteins from bacteria; Region: YdjC_like_3; cd10807 114615017024 putative active site [active] 114615017025 YdjC motif; other site 114615017026 Mg binding site [ion binding]; other site 114615017027 putative homodimer interface [polypeptide binding]; other site 114615017028 Uncharacterized protein conserved in bacteria (DUF2076); Region: DUF2076; pfam09849 114615017029 Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376 114615017030 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 114615017031 Chemotaxis phosphatase, CheZ; Region: CheZ; cl01219 114615017032 Chaperonin 10 Kd subunit (cpn10 or GroES); Cpn10 cooperates with chaperonin 60 (cpn60 or GroEL), an ATPase, to assist the folding and assembly of proteins and is found in eubacterial cytosol, as well as in the matrix of mitochondria and chloroplasts. It...; Region: cpn10; cd00320 114615017033 oligomerisation interface [polypeptide binding]; other site 114615017034 mobile loop; other site 114615017035 roof hairpin; other site 114615017036 chaperonin GroEL; Reviewed; Region: groEL; PRK12852 114615017037 GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344 114615017038 ring oligomerisation interface [polypeptide binding]; other site 114615017039 ATP/Mg binding site [chemical binding]; other site 114615017040 stacking interactions; other site 114615017041 hinge regions; other site 114615017042 META domain; Region: META; cl01245 114615017043 L-lactate permease; Region: Lactate_perm; cl00701 114615017044 L-lactate permease [Energy production and conversion]; Region: LldP; COG1620 114615017045 ABC-type uncharacterized transport system, permease and ATPase components [General function prediction only]; Region: COG4178 114615017046 ABC transporter transmembrane region 2; Region: ABC_membrane_2; cl00549 114615017047 ATP-binding cassette domain of peroxisomal transporter, subfamily D; Region: ABCD_peroxisomal_ALDP; cd03223 114615017048 Bacterial protein of unknown function (Gcw_chp); Region: Gcw_chp; cl09901 114615017049 glycolate oxidase iron-sulfur subunit; Provisional; Region: glcF; PRK11274 114615017050 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 114615017051 Cysteine-rich domain; Region: CCG; pfam02754 114615017052 Cysteine-rich domain; Region: CCG; pfam02754 114615017053 FAD binding domain; Region: FAD_binding_4; pfam01565 114615017054 glycolate oxidase FAD binding subunit; Provisional; Region: glcE; PRK11282 114615017055 Domain of unknown function (DUF4415); Region: DUF4415; pfam14384 114615017056 Uncharacterized conserved protein [Function unknown]; Region: COG1479 114615017057 Protein of unknown function DUF262; Region: DUF262; pfam03235 114615017058 Uncharacterized conserved protein [Function unknown]; Region: COG3472 114615017059 Uncharacterized conserved protein [Function unknown]; Region: COG3472 114615017060 glycolate oxidase subunit GlcD; Provisional; Region: PRK11230 114615017061 FAD binding domain; Region: FAD_binding_4; pfam01565 114615017062 Cytochrome c2 [Energy production and conversion]; Region: COG3474 114615017063 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 114615017064 Novel bacterial esterase that cleaves esters on halogenated cyclic compounds; Region: Esterase_713_like; cl17303 114615017065 catalytic site [active] 114615017066 TPR repeat; Region: TPR_11; pfam13414 114615017067 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 114615017068 binding surface 114615017069 TPR motif; other site 114615017070 TPR repeat; Region: TPR_11; pfam13414 114615017071 50S ribosomal protein L36; Validated; Region: rpmJ; PRK00831 114615017072 Predicted metal-dependent hydrolase of the TIM-barrel fold [General function prediction only]; Region: COG2159 114615017073 active site 114615017074 This CD, composed mainly of bacterial single-domain proteins, includes the Thermus thermophilus (Tt) YbaK-like protein, a homolog of the trans-acting Escherichia coli YbaK Cys-tRNA(Pro) deacylase and the Agrobacterium tumefaciens ProX Ala-tRNA(Pro)...; Region: ProX_deacylase; cd04333 114615017075 putative deacylase active site [active] 114615017076 Transcriptional regulator [Transcription]; Region: LysR; COG0583 114615017077 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 114615017078 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 114615017079 putative effector binding pocket; other site 114615017080 dimerization interface [polypeptide binding]; other site 114615017081 Pirin-related protein [General function prediction only]; Region: COG1741 114615017082 Pirin; Region: Pirin; pfam02678 114615017083 NAD(P)H:quinone oxidoreductase; Provisional; Region: PRK03767 114615017084 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 114615017085 Domain of Unknown Function (DUF1080); Region: DUF1080; pfam06439 114615017086 D-amino acid aminotransferase; Reviewed; Region: PRK06680 114615017087 Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115 114615017088 homodimer interface [polypeptide binding]; other site 114615017089 substrate-cofactor binding pocket; other site 114615017090 pyridoxal 5'-phosphate binding site [chemical binding]; other site 114615017091 catalytic residue [active] 114615017092 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 114615017093 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 114615017094 Walker A/P-loop; other site 114615017095 ATP binding site [chemical binding]; other site 114615017096 Q-loop/lid; other site 114615017097 ABC transporter signature motif; other site 114615017098 Walker B; other site 114615017099 D-loop; other site 114615017100 H-loop/switch region; other site 114615017101 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 114615017102 dimer interface [polypeptide binding]; other site 114615017103 conserved gate region; other site 114615017104 putative PBP binding loops; other site 114615017105 ABC-ATPase subunit interface; other site 114615017106 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 114615017107 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 114615017108 dimer interface [polypeptide binding]; other site 114615017109 conserved gate region; other site 114615017110 putative PBP binding loops; other site 114615017111 ABC-ATPase subunit interface; other site 114615017112 glutamate and aspartate transporter subunit; Provisional; Region: PRK10797 114615017113 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 114615017114 substrate binding pocket [chemical binding]; other site 114615017115 membrane-bound complex binding site; other site 114615017116 hinge residues; other site 114615017117 hypothetical protein; Provisional; Region: PRK07079 114615017118 Uncharacterized M20 Dipeptidases; Region: M20_dipept_like_2; cd05679 114615017119 metal binding site [ion binding]; metal-binding site 114615017120 putative dimer interface [polypeptide binding]; other site 114615017121 benzoylformate decarboxylase; Reviewed; Region: PRK07092 114615017122 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 114615017123 PYR/PP interface [polypeptide binding]; other site 114615017124 dimer interface [polypeptide binding]; other site 114615017125 TPP binding site [chemical binding]; other site 114615017126 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 114615017127 Thiamine pyrophosphate (TPP) family, BFDC subfamily, TPP-binding module; composed of proteins similar to Pseudomonas putida benzoylformate decarboxylase (BFDC). P. putida BFDC plays a role in the mandelate pathway, catalyzing the conversion of...; Region: TPP_BFDC; cd02002 114615017128 TPP-binding site [chemical binding]; other site 114615017129 dimer interface [polypeptide binding]; other site 114615017130 NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902 114615017131 Old yellow enzyme (OYE)-like FMN binding domain. OYE was the first flavin-dependent enzyme identified, however its true physiological role remains elusive to this day. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a...; Region: OYE_like_FMN; cd02933 114615017132 FMN binding site [chemical binding]; other site 114615017133 active site 114615017134 substrate binding site [chemical binding]; other site 114615017135 catalytic residue [active] 114615017136 N-terminal domain of molybdenum-binding protein [General function prediction only]; Region: ModE; COG2005 114615017137 hypothetical protein; Provisional; Region: PRK06194 114615017138 classical (c) SDRs; Region: SDR_c; cd05233 114615017139 NAD(P) binding site [chemical binding]; other site 114615017140 active site 114615017141 yiaA/B two helix domain; Region: YiaAB; cl01759 114615017142 Phage shock protein A (IM30), suppresses sigma54-dependent transcription [Transcription / Signal transduction mechanisms]; Region: PspA; COG1842 114615017143 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 114615017144 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 114615017145 WHG domain; Region: WHG; pfam13305 114615017146 Periplasmic binding protein; Region: Peripla_BP_6; pfam13458 114615017147 Type I periplasmic binding domain of uncharacterized extracellular ligand-binding proteins; Region: PBP1_STKc_like; cd06326 114615017148 putative ligand binding site [chemical binding]; other site 114615017149 Helix-turn-helix domain; Region: HTH_18; pfam12833 114615017150 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 114615017151 glucans biosynthesis protein; Provisional; Region: opgC; PRK03854 114615017152 Acyltransferase family; Region: Acyl_transf_3; pfam01757 114615017153 phenylhydantoinase; Validated; Region: PRK08323 114615017154 D-hydantoinases (D-HYD) also called dihydropyrimidases (DHPase) and related proteins; DHPases are a family of enzymes that catalyze the reversible hydrolytic ring opening of the amide bond in five- or six-membered cyclic diamides, like dihydropyrimidine...; Region: D-HYD; cd01314 114615017155 tetramer interface [polypeptide binding]; other site 114615017156 active site 114615017157 UDP-glucose 4-epimerase [Cell envelope biogenesis, outer membrane]; Region: GalE; COG1087 114615017158 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 114615017159 NAD(P) binding site [chemical binding]; other site 114615017160 active site 114615017161 Multidrug resistance efflux pump [Defense mechanisms]; Region: EmrA; COG1566 114615017162 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 114615017163 HlyD family secretion protein; Region: HlyD_3; pfam13437 114615017164 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 114615017165 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 114615017166 putative substrate translocation pore; other site 114615017167 Phosphate-selective porin [Inorganic ion transport and metabolism]; Region: OprP; COG3746 114615017168 Phosphate-selective porin O and P; Region: Porin_O_P; pfam07396 114615017169 Uncharacterized conserved protein [Function unknown]; Region: COG5476 114615017170 Protein of unknown function (DUF1485); Region: DUF1485; pfam07364 114615017171 MlrC C-terminus; Region: MlrC_C; pfam07171 114615017172 Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114 114615017173 cyclase homology domain; Region: CHD; cd07302 114615017174 nucleotidyl binding site; other site 114615017175 metal binding site [ion binding]; metal-binding site 114615017176 dimer interface [polypeptide binding]; other site 114615017177 2TM domain; Region: 2TM; pfam13239 114615017178 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 114615017179 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 114615017180 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 114615017181 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 114615017182 HlyD family secretion protein; Region: HlyD_3; pfam13437 114615017183 AcrB/AcrD/AcrF family; Region: ACR_tran; pfam00873 114615017184 triphenylmethane reductase (TMR)-like proteins, NMRa-like, atypical (a) SDRs; Region: TMR_SDR_a; cd05269 114615017185 Predicted nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG0702 114615017186 NADP binding site [chemical binding]; other site 114615017187 Predicted transcriptional regulators [Transcription]; Region: COG1733 114615017188 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 114615017189 Spermidine/putrescine-binding periplasmic protein [Amino acid transport and metabolism]; Region: PotD; COG0687 114615017190 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 114615017191 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 114615017192 ATP-binding cassette domain of the polyamine transporter; Region: ABC_PotA_N; cd03300 114615017193 Walker A/P-loop; other site 114615017194 ATP binding site [chemical binding]; other site 114615017195 Q-loop/lid; other site 114615017196 ABC transporter signature motif; other site 114615017197 Walker B; other site 114615017198 D-loop; other site 114615017199 H-loop/switch region; other site 114615017200 TOBE domain; Region: TOBE_2; pfam08402 114615017201 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 114615017202 dimer interface [polypeptide binding]; other site 114615017203 conserved gate region; other site 114615017204 putative PBP binding loops; other site 114615017205 ABC-ATPase subunit interface; other site 114615017206 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 114615017207 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 114615017208 dimer interface [polypeptide binding]; other site 114615017209 conserved gate region; other site 114615017210 putative PBP binding loops; other site 114615017211 ABC-ATPase subunit interface; other site 114615017212 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 114615017213 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 114615017214 NAD(P) binding site [chemical binding]; other site 114615017215 active site 114615017216 Beta-lactamase; Region: Beta-lactamase; pfam00144 114615017217 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 114615017218 TRAP transporter solute receptor, TAXI family; Region: TRAP_TAXI; TIGR02122 114615017219 Transcriptional regulator [Transcription]; Region: LysR; COG0583 114615017220 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 114615017221 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 114615017222 putative effector binding pocket; other site 114615017223 dimerization interface [polypeptide binding]; other site 114615017224 Flavodoxin-like fold; Region: Flavodoxin_2; cl00438 114615017225 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 114615017226 Ketopantoate reductase PanE/ApbA; Region: ApbA; pfam02558 114615017227 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084 114615017228 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 114615017229 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 114615017230 Coenzyme A binding pocket [chemical binding]; other site 114615017231 LanC-like proteins. LanC is the cyclase enzyme of the lanthionine synthetase. Lanthionine is a lantibiotic, a unique class of peptide antibiotics. They are ribosomally synthesized as a precursor peptide and then post-translationally modified to contain...; Region: LanC_like; cl04955 114615017232 active site 114615017233 zinc binding site [ion binding]; other site 114615017234 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 114615017235 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 114615017236 Coenzyme A binding pocket [chemical binding]; other site 114615017237 GNAT acetyltransferase 2; Region: GNAT_acetyltr_2; pfam13718 114615017238 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 114615017239 hypothetical protein; Provisional; Region: PRK09945 114615017240 type I secretion membrane fusion protein, HlyD family; Region: type_I_hlyD; TIGR01843 114615017241 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 114615017242 HlyD family secretion protein; Region: HlyD_3; pfam13437 114615017243 A sub-family of peptidase C39 which contains Cyclolysin and Hemolysin processing peptidases. Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the "double-glycine...; Region: Peptidase_C39_likeA; cd02417 114615017244 type I secretion system ABC transporter, HlyB family; Region: type_I_sec_HlyB; TIGR01846 114615017245 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 114615017246 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 114615017247 Walker A/P-loop; other site 114615017248 ATP binding site [chemical binding]; other site 114615017249 Q-loop/lid; other site 114615017250 ABC transporter signature motif; other site 114615017251 Walker B; other site 114615017252 D-loop; other site 114615017253 H-loop/switch region; other site 114615017254 Transposase, Mutator family; Region: Transposase_mut; pfam00872 114615017255 Conjugal transfer protein TraD; Region: TraD; pfam06412 114615017256 Conjugal transfer protein TraD; Region: TraD; pfam06412 114615017257 conjugal transfer relaxase TraA; Provisional; Region: PRK13889 114615017258 MobA/MobL family; Region: MobA_MobL; pfam03389 114615017259 AAA domain; Region: AAA_30; pfam13604 114615017260 Family description; Region: UvrD_C_2; pfam13538 114615017261 Predicted transcriptional regulator [Transcription]; Region: AlpA; COG3311 114615017262 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 114615017263 active site 114615017264 Int/Topo IB signature motif; other site 114615017265 DNA binding site [nucleotide binding] 114615017266 Response regulator receiver domain; Region: Response_reg; pfam00072 114615017267 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 114615017268 active site 114615017269 phosphorylation site [posttranslational modification] 114615017270 intermolecular recognition site; other site 114615017271 dimerization interface [polypeptide binding]; other site 114615017272 N-formylglutamate amidohydrolase [Amino acid transport and metabolism]; Region: HutG; COG3741 114615017273 Predominantly bacterial family of Mg++ dependend phosphatases, related to inositol monophosphatases. These enzymes may dephosphorylate fructose-1,6-bisphosphate, inositol monophospate, 3'-phosphoadenosine-5'-phosphate, or similar substrates; Region: Bacterial_IMPase_like_1; cd01641 114615017274 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483 114615017275 active site 114615017276 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 114615017277 dimerization interface [polypeptide binding]; other site 114615017278 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 114615017279 dimer interface [polypeptide binding]; other site 114615017280 putative CheW interface [polypeptide binding]; other site 114615017281 Transcriptional regulator [Transcription]; Region: LysR; COG0583 114615017282 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 114615017283 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator, contains the type 2 periplasmic binding fold; Region: PBP2_LTTR_like_1; cd08421 114615017284 putative dimerization interface [polypeptide binding]; other site 114615017285 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 114615017286 Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280 114615017287 Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114 114615017288 cyclase homology domain; Region: CHD; cd07302 114615017289 nucleotidyl binding site; other site 114615017290 metal binding site [ion binding]; metal-binding site 114615017291 dimer interface [polypeptide binding]; other site 114615017292 Predicted integral membrane protein [Function unknown]; Region: COG5616 114615017293 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 114615017294 TPR motif; other site 114615017295 binding surface 114615017296 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 114615017297 TPR motif; other site 114615017298 binding surface 114615017299 Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114 114615017300 cyclase homology domain; Region: CHD; cd07302 114615017301 nucleotidyl binding site; other site 114615017302 metal binding site [ion binding]; metal-binding site 114615017303 dimer interface [polypeptide binding]; other site 114615017304 Predicted integral membrane protein [Function unknown]; Region: COG5616 114615017305 TPR repeat; Region: TPR_11; pfam13414 114615017306 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 114615017307 TPR motif; other site 114615017308 binding surface 114615017309 TPR repeat; Region: TPR_11; pfam13414 114615017310 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 114615017311 TPR motif; other site 114615017312 binding surface 114615017313 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3002 114615017314 Uncharacterized protein conserved in bacteria (DUF2309); Region: DUF2309; pfam10070 114615017315 NADH dehydrogenase subunit L; Provisional; Region: PRK08168 114615017316 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 114615017317 transcriptional activator NhaR; Provisional; Region: nhaR; PRK11062 114615017318 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 114615017319 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 114615017320 dimerization interface [polypeptide binding]; other site 114615017321 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920 114615017322 HWE histidine kinase; Region: HWE_HK; smart00911 114615017323 Putative Flp pilus-assembly TadE/G-like; Region: Tad; pfam13400 114615017324 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 114615017325 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 114615017326 S-adenosylmethionine binding site [chemical binding]; other site 114615017327 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 114615017328 DNA-binding site [nucleotide binding]; DNA binding site 114615017329 This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895 114615017330 Type I periplasmic ligand-binding domain of uncharacterized ABC (ATPase Binding Cassette)-type active transport systems that are predicted to be involved in uptake of amino acids, peptides, or inorganic ions; Region: PBP1_ABC_ligand_binding_like_8; cd06343 114615017331 Periplasmic binding protein; Region: Peripla_BP_6; pfam13458 114615017332 putative ligand binding site [chemical binding]; other site 114615017333 Lysophospholipase [Lipid metabolism]; Region: PldB; COG2267 114615017334 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 114615017335 Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071 114615017336 Alpha-crystallin domain (ACD) found in Escherichia coli inclusion body-associated proteins IbpA and IbpB, and similar proteins. IbpA and IbpB are 16 kDa small heat shock proteins (sHsps). sHsps are molecular chaperones that suppress protein aggregation...; Region: ACD_IbpA-B_like; cd06470 114615017337 putative dimer interface [polypeptide binding]; other site 114615017338 glutamate synthase subunit alpha; Provisional; Region: gltB; PRK11750 114615017339 Glutamine amidotransferases class-II (Gn-AT), glutamate synthase (GltS)-type. GltS is a homodimer that synthesizes L-glutamate from 2-oxoglutarate and L-glutamine, an important step in ammonia assimilation in bacteria, cyanobacteria and plants. The...; Region: GltS; cd00713 114615017340 active site 114615017341 dimer interface [polypeptide binding]; other site 114615017342 Glutamate synthase central domain; Region: Glu_syn_central; pfam04898 114615017343 Glutamate synthase (GltS) FMN-binding domain. GltS is a complex iron-sulfur flavoprotein that catalyzes the reductive synthesis of L-glutamate from 2-oxoglutarate and L-glutamine via intramolecular channelling of ammonia, a reaction in the plant, yeast...; Region: GltS_FMN; cd02808 114615017344 active site 114615017345 FMN binding site [chemical binding]; other site 114615017346 substrate binding site [chemical binding]; other site 114615017347 3Fe-4S cluster binding site [ion binding]; other site 114615017348 gltb_C. This domain is found at the C-terminus of the large subunit (gltB) of glutamate synthase (GltS). GltS encodes a complex iron-sulfur flavoprotein that catalyzes the synthesis of L-glutamate from L-glutamine and 2-oxoglutarate. It requires the...; Region: gltB_C; cd00982 114615017349 domain interface; other site 114615017350 glutamate synthase subunit beta; Reviewed; Region: gltD; PRK12810 114615017351 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 114615017352 N-acetyltransferase; Region: Acetyltransf_2; pfam00797 114615017353 N-acetyltransferase; Region: Acetyltransf_2; pfam00797 114615017354 Predicted transcriptional regulators [Transcription]; Region: COG1733 114615017355 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 114615017356 Carboxymuconolactone decarboxylase family; Region: CMD; pfam02627 114615017357 KpsF/GutQ family protein; Region: kpsF; TIGR00393 114615017358 KpsF-like protein. KpsF is an arabinose-5-phosphate isomerase which contains SIS (Sugar ISomerase) domains. SIS domains are found in many phosphosugar isomerases and phosphosugar binding proteins. KpsF catalyzes the reversible reaction of ribulose...; Region: SIS_Kpsf; cd05014 114615017359 putative active site [active] 114615017360 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with KpsF/GutQ domains in the API [A5P (D-arabinose 5-phosphate) isomerase] protein. These APIs catalyze the conversion of the pentose pathway...; Region: CBS_pair_KpsF_GutQ_assoc; cd04604 114615017361 Uncharacterized protein conserved in bacteria (DUF2320); Region: DUF2320; pfam10082 114615017362 Membrane protein implicated in regulation of membrane protease activity [Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: COG1585 114615017363 Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330 114615017364 Band_7_stomatin_like: A subgroup of the band 7 domain of flotillin (reggie) like proteins similar to stomatin and podicin (two lipid raft-associated integral membrane proteins). Individual proteins of this band 7 domain family may cluster to form...; Region: Band_7_stomatin_like; cd03403 114615017365 ferrochelatase; Reviewed; Region: hemH; PRK00035 114615017366 Ferrochelatase, N-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_N; cd03411 114615017367 C-terminal domain interface [polypeptide binding]; other site 114615017368 active site 114615017369 Ferrochelatase, C-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_C; cd00419 114615017370 active site 114615017371 N-terminal domain interface [polypeptide binding]; other site 114615017372 MAPEG family; Region: MAPEG; cl09190 114615017373 Squalene cyclase (SQCY) domain subgroup 1; found in class II terpene cyclases that have an alpha 6 - alpha 6 barrel fold. Squalene cyclase (SQCY) and 2,3-oxidosqualene cyclase (OSQCY) are integral membrane proteins that catalyze a cationic cyclization...; Region: SQCY_1; cd02892 114615017374 squalene-hopene cyclase; Region: hopene_cyclase; TIGR01507 114615017375 Active site cavity [active] 114615017376 catalytic acid [active] 114615017377 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 114615017378 NAD(P) binding site [chemical binding]; other site 114615017379 active site 114615017380 SnoaL-like domain; Region: SnoaL_2; pfam12680 114615017381 Transcriptional regulator [Transcription]; Region: LysR; COG0583 114615017382 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 114615017383 The C-terminal substrate binding domain of LysR-type transcriptional regulators that involved in the catabolism of nitroaromatic/naphthalene compounds and that of related regulators; contains the type 2 periplasmic binding fold; Region: PBP2_Nitroaromatics_like; cd08417 114615017384 substrate binding pocket [chemical binding]; other site 114615017385 dimerization interface [polypeptide binding]; other site 114615017386 High-affinity nickel-transport protein; Region: NicO; cl00964 114615017387 High-affinity nickel-transport protein; Region: NicO; cl00964 114615017388 Protein of unknown function (DUF1007); Region: DUF1007; pfam06226 114615017389 Zn-dependent oligopeptidases [Amino acid transport and metabolism]; Region: Dcp; COG0339 114615017390 Peptidase family M3 dipeptidyl carboxypeptidase (DCP); Region: M3A_DCP; cd06456 114615017391 active site 114615017392 Zn binding site [ion binding]; other site 114615017393 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Ornithine Decarboxylase; Region: PLPDE_III_ODC; cd00622 114615017394 dimer interface [polypeptide binding]; other site 114615017395 Diaminopimelate decarboxylase [Amino acid transport and metabolism]; Region: LysA; COG0019 114615017396 active site 114615017397 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 114615017398 catalytic residues [active] 114615017399 substrate binding site [chemical binding]; other site 114615017400 Predicted acetyltransferase [General function prediction only]; Region: COG3153 114615017401 This group of proteins belong to a large family of YjgF/YER057c/UK114-like proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence...; Region: YjgF_YER057c_UK114_like_6; cd06154 114615017402 homotrimer interaction site [polypeptide binding]; other site 114615017403 putative active site [active] 114615017404 Homospermidine synthase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG5310 114615017405 Saccharopine dehydrogenase; Region: Saccharop_dh; pfam03435 114615017406 FOG: WD40 repeat [General function prediction only]; Region: COG2319 114615017407 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cl02567 114615017408 Putative GTPases (G3E family) [General function prediction only]; Region: COG0523 114615017409 The function of this protein family is unkown. The amino acid sequence of YjiA protein in E. coli contains several conserved motifs that characterizes it as a P-loop GTPase. YijA gene is among the genes significantly induced in response to DNA-damage...; Region: CobW_like; cd03112 114615017410 P-loop, Walker A motif; other site 114615017411 Base recognition motif; other site 114615017412 Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; pfam07683 114615017413 ABC-type metal ion transport system, periplasmic component/surface adhesin [Inorganic ion transport and metabolism]; Region: LraI; COG0803 114615017414 Metal binding protein PsaA. These proteins have been shown to function as initial receptors in ABC transport of Mn2+ and as surface adhesins in some eubacterial species. They belong to the TroA superfamily of periplasmic metal binding proteins that...; Region: PsaA; cd01137 114615017415 metal binding site [ion binding]; metal-binding site 114615017416 ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108 114615017417 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 114615017418 ABC-ATPase subunit interface; other site 114615017419 dimer interface [polypeptide binding]; other site 114615017420 putative PBP binding regions; other site 114615017421 ABC-type Mn/Zn transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: ZnuC; COG1121 114615017422 ATP-binding cassette domain of the metal-type transporters; Region: ABC_Metallic_Cations; cd03235 114615017423 camphor resistance protein CrcB; Provisional; Region: PRK14198 114615017424 Superoxide dismutase [Inorganic ion transport and metabolism]; Region: SodA; COG0605 114615017425 Iron/manganese superoxide dismutases, alpha-hairpin domain; Region: Sod_Fe_N; pfam00081 114615017426 Iron/manganese superoxide dismutases, C-terminal domain; Region: Sod_Fe_C; pfam02777 114615017427 Acetyltransferase (GNAT) domain; Region: Acetyltransf_7; pfam13508 114615017428 Uncharacterized protein conserved in bacteria (DUF2147); Region: DUF2147; pfam09917 114615017429 Protein of unknown function (DUF3095); Region: DUF3095; pfam11294 114615017430 Uncharacterized ACR, YagE family COG1723; Region: DUF155; pfam02582 114615017431 Uncharacterized membrane protein [Function unknown]; Region: SapB; COG1285 114615017432 MgtC family; Region: MgtC; pfam02308 114615017433 Cytochrome c; Region: Cytochrom_C; cl11414 114615017434 Cytochrome c; Region: Cytochrom_C; pfam00034 114615017435 Cytochrome c; Region: Cytochrom_C; cl11414 114615017436 Cytochrome c; Region: Cytochrom_C; pfam00034 114615017437 Opacity protein and related surface antigens [Cell envelope biogenesis, outer membrane]; Region: COG3637 114615017438 Cytochrome c; Region: Cytochrom_C; cl11414 114615017439 Cytochrome c; Region: Cytochrom_C; pfam00034 114615017440 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 114615017441 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 114615017442 ligand binding site [chemical binding]; other site 114615017443 flexible hinge region; other site 114615017444 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 114615017445 putative switch regulator; other site 114615017446 non-specific DNA interactions [nucleotide binding]; other site 114615017447 DNA binding site [nucleotide binding] 114615017448 sequence specific DNA binding site [nucleotide binding]; other site 114615017449 putative cAMP binding site [chemical binding]; other site 114615017450 heavy metal-(Cd/Co/Hg/Pb/Zn)-translocating P-type ATPase; Region: ATPase-IB2_Cd; TIGR01512 114615017451 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 114615017452 Hemerythrin-like domain; Region: Hr-like; cd12108 114615017453 Fe binding site [ion binding]; other site 114615017454 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 114615017455 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 114615017456 NAD(P) binding site [chemical binding]; other site 114615017457 active site 114615017458 amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733 114615017459 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 114615017460 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 114615017461 acyl-activating enzyme (AAE) consensus motif; other site 114615017462 acyl-activating enzyme (AAE) consensus motif; other site 114615017463 AMP binding site [chemical binding]; other site 114615017464 active site 114615017465 CoA binding site [chemical binding]; other site 114615017466 Phosphopantetheine attachment site; Region: PP-binding; cl09936 114615017467 long-chain-acyl-CoA synthetase; Validated; Region: PRK08279 114615017468 Fatty acid transport proteins (FATP) play dual roles as fatty acid transporters and its activation enzymes; Region: FATP_FACS; cd05940 114615017469 acyl-activating enzyme (AAE) consensus motif; other site 114615017470 putative AMP binding site [chemical binding]; other site 114615017471 putative active site [active] 114615017472 putative CoA binding site [chemical binding]; other site 114615017473 Tripartite tricarboxylate transporter family receptor; Region: TctC; cl17792 114615017474 heat shock protein 90; Provisional; Region: PRK05218 114615017475 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 114615017476 ATP binding site [chemical binding]; other site 114615017477 Mg2+ binding site [ion binding]; other site 114615017478 G-X-G motif; other site 114615017479 Transcriptional regulators [Transcription]; Region: MarR; COG1846 114615017480 MarR family; Region: MarR_2; pfam12802 114615017481 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 114615017482 N-terminal domain of Sphingobium chlorophenolicum 2,6-dichloro-p-hydroquinone 1,2-dioxygenase (PcpA), and similar proteins; Region: PcpA_N_like; cd08346 114615017483 Zn binding site [ion binding]; other site 114615017484 FAD-dependent oxidoreductase; Provisional; Region: PRK08132 114615017485 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 114615017486 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 114615017487 Protein of unknown function (DUF2783); Region: DUF2783; pfam10932 114615017488 Putative silver efflux pump [Inorganic ion transport and metabolism]; Region: COG3696 114615017489 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 114615017490 Part of AAA domain; Region: AAA_19; pfam13245 114615017491 Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; pfam03781 114615017492 Uncharacterized conserved protein [Function unknown]; Region: COG1262 114615017493 Domain of unknown function (DUF4399); Region: DUF4399; pfam14347 114615017494 Peptidase propeptide and YPEB domain; Region: PepSY_2; pfam13670 114615017495 Cytochrome b (N-terminus)/b6/petB: Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria; Region: Cytochrome_b_N; cl00859 114615017496 Cupredoxin-like domain; Region: Cupredoxin_1; pfam13473 114615017497 Uncharacterized protein conserved in bacteria (DUF2320); Region: DUF2320; pfam10082 114615017498 Periplasmic protein TonB, links inner and outer membranes [Cell envelope biogenesis, outer membrane]; Region: TonB; COG0810 114615017499 TonB family C-terminal domain; Region: tonB_Cterm; TIGR01352 114615017500 Biopolymer transport protein ExbD/TolR; Region: ExbD; cl00537 114615017501 Biopolymer transport protein [Intracellular trafficking and secretion]; Region: ExbD; COG0848 114615017502 tonB-system energizer ExbB; Region: exbB; TIGR02797 114615017503 Fe(II)-dependent oxygenase superfamily protein; Provisional; Region: PRK05467 114615017504 catecholate siderophore receptor Fiu; Provisional; Region: PRK09840 114615017505 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 114615017506 N-terminal plug; other site 114615017507 ligand-binding site [chemical binding]; other site 114615017508 Outer membrane receptor for monomeric catechols [Inorganic ion transport and metabolism]; Region: Fiu; COG4774 114615017509 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 114615017510 N-terminal plug; other site 114615017511 ligand-binding site [chemical binding]; other site 114615017512 Amidohydrolase ring-opening protein (Amido_AtzD_TrzD); Region: Amido_AtzD_TrzD; pfam09663 114615017513 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 114615017514 Domain of unknown function (DUF427); Region: DUF427; pfam04248 114615017515 thiamine pyrophosphate protein; Provisional; Region: PRK08273 114615017516 Pyrimidine (PYR) binding domain of POX; Region: TPP_PYR_POX; cd07039 114615017517 PYR/PP interface [polypeptide binding]; other site 114615017518 dimer interface [polypeptide binding]; other site 114615017519 tetramer interface [polypeptide binding]; other site 114615017520 TPP binding site [chemical binding]; other site 114615017521 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 114615017522 Thiamine pyrophosphate (TPP) family, Pyruvate oxidase (POX) subfamily, TPP-binding module; composed of proteins similar to Lactobacillus plantarum POX, which plays a key role in controlling acetate production under aerobic conditions. POX decarboxylates...; Region: TPP_POX; cd02014 114615017523 TPP-binding site [chemical binding]; other site 114615017524 Mandelate racemase (MR)-like subfamily of the enolase superfamily, subgroup 3. Enzymes of this subgroup share three conserved carboxylate ligands for the essential divalent metal ion (usually Mg2+), two aspartates and a glutamate, and conserved catalytic...; Region: MR_like_3; cd03328 114615017525 L-alanine-DL-glutamate epimerase and related enzymes of enolase superfamily [Cell envelope biogenesis, outer membrane / General function prediction only]; Region: COG4948 114615017526 putative active site pocket [active] 114615017527 putative metal binding site [ion binding]; other site 114615017528 Gluconate 2-dehydrogenase subunit 3; Region: Gluconate_2-dh3; pfam13618 114615017529 Choline dehydrogenase and related flavoproteins [Amino acid transport and metabolism]; Region: BetA; COG2303 114615017530 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 114615017531 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 114615017532 Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490 114615017533 putative catalytic site [active] 114615017534 putative metal binding site [ion binding]; other site 114615017535 putative phosphate binding site [ion binding]; other site 114615017536 Jacalin-like lectin domains of putative endonucleases/exonucleases/phosphatases and related proteins; Region: Jacalin_EEP; cd09615 114615017537 putative sugar binding site [chemical binding]; other site 114615017538 Ricin-type beta-trefoil; Carbohydrate-binding domain formed from presumed gene triplication. The domain is found in a variety of molecules serving diverse functions such as enzymatic activity, inhibitory toxicity and signal transduction. Highly specific...; Region: RICIN; cd00161 114615017539 Ricin-type beta-trefoil lectin domain; Region: Ricin_B_lectin; pfam00652 114615017540 putative sugar binding sites [chemical binding]; other site 114615017541 Q-X-W motif; other site 114615017542 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 114615017543 Putative 2OG-Fe(II) oxygenase; Region: 2OG-FeII_Oxy_5; pfam13759 114615017544 PPIC-type PPIASE domain; Region: Rotamase_2; pfam13145 114615017545 HupE / UreJ protein; Region: HupE_UreJ_2; pfam13795 114615017546 HupE / UreJ protein; Region: HupE_UreJ; pfam04955 114615017547 Type II secretion system (T2SS), protein M subtype b; Region: T2SM_b; pfam10741 114615017548 Fimbrial assembly protein (PilN); Region: PilN; pfam05137 114615017549 Type II secretion system (T2SS), protein K; Region: T2SK; pfam03934 114615017550 Archaeal/vacuolar-type H+-ATPase subunit A [Energy production and conversion]; Region: NtpA; COG1155 114615017551 type II secretion system protein H; Region: typeII_sec_gspH; TIGR01708 114615017552 prepilin-type N-terminal cleavage/methylation domain; Region: IV_pilin_GFxxxE; TIGR02532 114615017553 type II secretion system protein G; Region: typeII_sec_gspG; TIGR01710 114615017554 Type II secretion system (T2SS), protein G; Region: T2SG; pfam08334 114615017555 Type II secretory pathway, component PulF [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulF; COG1459 114615017556 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 114615017557 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 114615017558 Type II secretory pathway, ATPase PulE/Tfp pilus assembly pathway, ATPase PilB [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulE; COG2804 114615017559 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 114615017560 Walker A motif; other site 114615017561 ATP binding site [chemical binding]; other site 114615017562 Walker B motif; other site 114615017563 type II secretion system protein D; Region: type_II_gspD; TIGR02517 114615017564 Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958 114615017565 Bacterial type II and III secretion system protein; Region: Secretin; pfam00263 114615017566 FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790 114615017567 Sel1-like repeats; Region: SEL1; smart00671 114615017568 Sel1-like repeats; Region: SEL1; smart00671 114615017569 acid phosphatase, Burkholderia-type; Region: acid_phos_Burk; TIGR03397 114615017570 Pyruvate phosphate dikinase, PEP/pyruvate binding domain; Region: PPDK_N; pfam01326 114615017571 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 114615017572 Uncharacterized FAD-dependent dehydrogenases [General function prediction only]; Region: COG2509 114615017573 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 114615017574 Carbohydrate-selective porin, OprB family; Region: OprB; pfam04966 114615017575 CorA-like Mg2+ transporter protein; Region: CorA; pfam01544 114615017576 Uncharacterized bacterial subgroup of the Salmonella typhimurium Zn2+ transporter ZntB-like subfamily; Region: ZntB_u1; cd12834 114615017577 Cl binding site [ion binding]; other site 114615017578 oligomer interface [polypeptide binding]; other site 114615017579 Phosphate/sulphate permeases [Inorganic ion transport and metabolism]; Region: PitA; COG0306 114615017580 Phosphate/sulphate permeases [Inorganic ion transport and metabolism]; Region: PitA; COG0306 114615017581 bifunctional enoyl-CoA hydratase/phosphate acetyltransferase; Validated; Region: PRK08190 114615017582 (R)-hydratase [(R)-specific enoyl-CoA hydratase] catalyzes the hydration of trans-2-enoyl CoA to (R)-3-hydroxyacyl-CoA as part of the PHA (polyhydroxyalkanoate) biosynthetic pathway. (R)-hydratase contains a hot-dog fold similar to those of thioesterase...; Region: R_hydratase; cd03449 114615017583 dimer interaction site [polypeptide binding]; other site 114615017584 substrate-binding tunnel; other site 114615017585 active site 114615017586 catalytic site [active] 114615017587 substrate binding site [chemical binding]; other site 114615017588 Phosphate acetyl/butaryl transferase; Region: PTA_PTB; cl17212 114615017589 propionate/acetate kinase; Provisional; Region: PRK12379 114615017590 acetate kinase A/propionate kinase 2; Reviewed; Region: PRK00180 114615017591 Protein of unknown function (DUF3141); Region: DUF3141; pfam11339 114615017592 enoyl-(acyl carrier protein) reductase; Provisional; Region: PRK07533 114615017593 Enoyl acyl carrier protein (ACP) reductase (ENR), divergent SDR; Region: ENR_SDR; cd05372 114615017594 NAD binding site [chemical binding]; other site 114615017595 homotetramer interface [polypeptide binding]; other site 114615017596 homodimer interface [polypeptide binding]; other site 114615017597 substrate binding site [chemical binding]; other site 114615017598 active site 114615017599 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 114615017600 Beta-lactamase; Region: Beta-lactamase; pfam00144 114615017601 Predicted acyltransferases [Lipid metabolism]; Region: COG1835 114615017602 PAP2_like proteins, a super-family of histidine phosphatases and vanadium haloperoxidases, includes type 2 phosphatidic acid phosphatase or lipid phosphate phosphatase (LPP), Glucose-6-phosphatase, Phosphatidylglycerophosphatase B and bacterial acid...; Region: PAP2_like; cl00474 114615017603 active site 114615017604 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 114615017605 Type IV secretion-system coupling protein DNA-binding domain; Region: TrwB_AAD_bind; pfam10412 114615017606 Walker A motif; other site 114615017607 ATP binding site [chemical binding]; other site 114615017608 Walker B motif; other site 114615017609 Peptidase family M48; Region: Peptidase_M48; cl12018 114615017610 Replication protein; Region: Rep_1; cl02412 114615017611 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 114615017612 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 114615017613 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 114615017614 Ankyrin repeats (many copies); Region: Ank_4; pfam13637 114615017615 Predicted amidohydrolase [General function prediction only]; Region: COG0388 114615017616 Nitrilase superfamily, including nitrile- or amide-hydrolyzing enzymes and amide-condensing enzymes; Region: nitrilase; cd07197 114615017617 active site 114615017618 catalytic triad [active] 114615017619 dimer interface [polypeptide binding]; other site 114615017620 Antirestriction protein [DNA replication, recombination, and repair]; Region: COG4227 114615017621 Domain of unknown function (DUF1738); Region: DUF1738; pfam08401 114615017622 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 114615017623 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 114615017624 non-specific DNA binding site [nucleotide binding]; other site 114615017625 salt bridge; other site 114615017626 sequence-specific DNA binding site [nucleotide binding]; other site 114615017627 Domain of unknown function (DUF955); Region: DUF955; cl01076 114615017628 Domain of unknown function (DUF4411); Region: DUF4411; pfam14367 114615017629 Predicted nucleotide-binding protein containing TIR-like domain; Region: TIR-like; cl17861 114615017630 Fic family protein [Function unknown]; Region: COG3177 114615017631 Domain of unknown function (DUF4172); Region: DUF4172; pfam13776 114615017632 Fic/DOC family; Region: Fic; pfam02661 114615017633 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 114615017634 sequence-specific DNA binding site [nucleotide binding]; other site 114615017635 salt bridge; other site 114615017636 WGR domain of molybdate metabolism regulator and related proteins; Region: WGR_MMR_like; cd07996 114615017637 multiple promoter invertase; Provisional; Region: mpi; PRK13413 114615017638 Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and...; Region: SR_ResInv; cd03768 114615017639 catalytic residues [active] 114615017640 catalytic nucleophile [active] 114615017641 Presynaptic Site I dimer interface [polypeptide binding]; other site 114615017642 Synaptic Antiparallel dimer interface [polypeptide binding]; other site 114615017643 Synaptic Flat tetramer interface [polypeptide binding]; other site 114615017644 Synaptic Site I dimer interface [polypeptide binding]; other site 114615017645 DNA binding site [nucleotide binding] 114615017646 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cd00569 114615017647 DNA-binding interface [nucleotide binding]; DNA binding site 114615017648 Protein of unknown function (DUF4238); Region: DUF4238; pfam14022 114615017649 Phage integrase, N-terminal; Region: Integrase_l_N; pfam12834 114615017650 DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182 114615017651 active site 114615017652 catalytic residues [active] 114615017653 DNA binding site [nucleotide binding] 114615017654 Int/Topo IB signature motif; other site 114615017655 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 114615017656 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 114615017657 P-loop; other site 114615017658 Magnesium ion binding site [ion binding]; other site 114615017659 Replication initiator protein A; Region: RPA; pfam10134 114615017660 multiple promoter invertase; Provisional; Region: mpi; PRK13413 114615017661 Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and...; Region: SR_ResInv; cd03768 114615017662 catalytic residues [active] 114615017663 catalytic nucleophile [active] 114615017664 Presynaptic Site I dimer interface [polypeptide binding]; other site 114615017665 Synaptic Antiparallel dimer interface [polypeptide binding]; other site 114615017666 Synaptic Flat tetramer interface [polypeptide binding]; other site 114615017667 Synaptic Site I dimer interface [polypeptide binding]; other site 114615017668 DNA binding site [nucleotide binding] 114615017669 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cd00569 114615017670 DNA-binding interface [nucleotide binding]; DNA binding site 114615017671 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961 114615017672 Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cd00338 114615017673 catalytic residues [active] 114615017674 catalytic nucleophile [active] 114615017675 Recombinase; Region: Recombinase; pfam07508 114615017676 Recombinase zinc beta ribbon domain; Region: Zn_ribbon_recom; pfam13408 114615017677 Coniferyl aldehyde dehydrogenase-like; Region: ALDH_CALDH_CalB; cd07133 114615017678 NAD(P) binding site [chemical binding]; other site 114615017679 catalytic residues [active] 114615017680 choline dehydrogenase; Validated; Region: PRK02106 114615017681 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 114615017682 short chain dehydrogenase; Provisional; Region: PRK06949 114615017683 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 114615017684 NAD(P) binding site [chemical binding]; other site 114615017685 active site 114615017686 Colicin V production protein; Region: Colicin_V; pfam02674 114615017687 short chain dehydrogenase; Provisional; Region: PRK08339 114615017688 putative beta-ketoacyl acyl carrier protein [ACP] reductase (BKR)-like, SDR; Region: BKR_like_SDR_like; cd05344 114615017689 putative NAD(P) binding site [chemical binding]; other site 114615017690 putative active site [active] 114615017691 Protein of unknown function (DUF3775); Region: DUF3775; pfam12616 114615017692 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 114615017693 2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179 114615017694 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557 114615017695 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 114615017696 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 114615017697 C-terminal, alpha helical domain of an unknown subfamily 6 of Glutathione S-transferases; Region: GST_C_6; cd03205 114615017698 dimer interface [polypeptide binding]; other site 114615017699 N-terminal domain interface [polypeptide binding]; other site 114615017700 putative substrate binding pocket (H-site) [chemical binding]; other site 114615017701 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 114615017702 Methylated DNA-protein cysteine methyltransferase [DNA replication, recombination, and repair]; Region: Ada; COG0350 114615017703 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 114615017704 DNA binding site [nucleotide binding] 114615017705 active site 114615017706 glutamate carboxypeptidase; Reviewed; Region: PRK06133 114615017707 M20 Peptidase Glutamate carboxypeptidase, a periplasmic enzyme; Region: M20_CPDG2; cd03885 114615017708 metal binding site [ion binding]; metal-binding site 114615017709 dimer interface [polypeptide binding]; other site 114615017710 Phytanoyl-CoA dioxygenase (PhyH); Region: PhyH; cl17312 114615017711 Predicted homoserine dehydrogenase [Amino acid transport and metabolism]; Region: COG4091 114615017712 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 114615017713 NAD(P) binding site [chemical binding]; other site 114615017714 SAF domain of putative dehydrogenases or oxidoreductases; Region: SAF_DH_OX_like; cd11616 114615017715 Transposase; Region: HTH_Tnp_1; pfam01527 114615017716 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 114615017717 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436 114615017718 IS66 Orf2 like protein; Region: TnpB_IS66; pfam05717 114615017719 putative Helix-turn-helix domain of transposase IS66; Region: HTH_Tnp_IS66; pfam13005 114615017720 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436 114615017721 Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050 114615017722 IS66 C-terminal element; Region: DDE_Tnp_IS66_C; pfam13817 114615017723 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 114615017724 Peptidase family M23; Region: Peptidase_M23; pfam01551 114615017725 ATP-dependent chaperone ClpB; Region: chaperone_ClpB; TIGR03346 114615017726 Clp amino terminal domain; Region: Clp_N; pfam02861 114615017727 Clp amino terminal domain; Region: Clp_N; pfam02861 114615017728 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 114615017729 Walker A motif; other site 114615017730 ATP binding site [chemical binding]; other site 114615017731 Walker B motif; other site 114615017732 arginine finger; other site 114615017733 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 114615017734 Walker A motif; other site 114615017735 ATP binding site [chemical binding]; other site 114615017736 Walker B motif; other site 114615017737 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 114615017738 Uncharacterized Fe-S protein [General function prediction only]; Region: COG3217 114615017739 MOSC N-terminal beta barrel domain; Region: MOSC_N; pfam03476 114615017740 MOSC domain; Region: MOSC; pfam03473 114615017741 TIGR02594 family protein; Region: TIGR02594 114615017742 3-oxoadipate enol-lactonase; Region: protocat_pcaD; TIGR02427 114615017743 homoserine O-acetyltransferase; Provisional; Region: metX; cl17114 114615017744 Transcriptional regulator [Transcription]; Region: LysR; COG0583 114615017745 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 114615017746 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_2; cd08471 114615017747 putative effector binding pocket; other site 114615017748 putative dimerization interface [polypeptide binding]; other site 114615017749 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 114615017750 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 114615017751 AAA domain; Region: AAA_17; pfam13207 114615017752 Uncharacterized conserved protein [Function unknown]; Region: COG0432 114615017753 ATP-grasp domain; Region: ATP-grasp_4; cl17255 114615017754 Methyltransferase domain; Region: Methyltransf_23; pfam13489 114615017755 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 114615017756 S-adenosylmethionine binding site [chemical binding]; other site 114615017757 homoserine O-acetyltransferase; Provisional; Region: metX; PRK00175 114615017758 homoserine O-acetyltransferase; Region: homoserO_Ac_trn; TIGR01392 114615017759 hypothetical protein; Provisional; Region: PRK06034 114615017760 Chorismate mutase type II; Region: CM_2; pfam01817 114615017761 histidinol-phosphate aminotransferase; Validated; Region: PRK02731 114615017762 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 114615017763 pyridoxal 5'-phosphate binding site [chemical binding]; other site 114615017764 homodimer interface [polypeptide binding]; other site 114615017765 catalytic residue [active] 114615017766 cyclohexadienyl dehydrogenase; Validated; Region: PRK07502 114615017767 prephenate dehydrogenase; Validated; Region: PRK08507 114615017768 Uncharacterized protein conserved in bacteria (DUF2125); Region: DUF2125; pfam09898 114615017769 GGCT-like domains, also called AIG2-like family. Gamma-glutamyl cyclotransferase (GGCT) catalyzes the formation of pyroglutamic acid (5-oxoproline) from dipeptides containing gamma-glutamyl, and is a dimeric protein. In Homo sapiens, the protein is...; Region: GGCT_like; cd06661 114615017770 putative active site pocket [active] 114615017771 dimerization interface [polypeptide binding]; other site 114615017772 putative catalytic residue [active] 114615017773 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 114615017774 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 114615017775 putative acyl-acceptor binding pocket; other site 114615017776 Uncharacterized conserved protein [Function unknown]; Region: COG1434 114615017777 YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259 114615017778 putative active site [active] 114615017779 Cell division protein [Cell division and chromosome partitioning]; Region: FtsX; COG2177 114615017780 cell division ABC transporter subunit FtsX; Provisional; Region: ftsX; PRK11026 114615017781 Predicted ATPase involved in cell division [Cell division and chromosome partitioning]; Region: FtsE; COG2884 114615017782 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 114615017783 Walker A/P-loop; other site 114615017784 ATP binding site [chemical binding]; other site 114615017785 Q-loop/lid; other site 114615017786 ABC transporter signature motif; other site 114615017787 Walker B; other site 114615017788 D-loop; other site 114615017789 H-loop/switch region; other site 114615017790 Protein of unknown function (DUF3426); Region: DUF3426; pfam11906 114615017791 C-Terminal domain of O-antigenic polysaccharide transporter protein Wzt and related proteins; Region: Wzt_C-like; cd10147 114615017792 Response regulator receiver domain; Region: Response_reg; pfam00072 114615017793 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 114615017794 active site 114615017795 phosphorylation site [posttranslational modification] 114615017796 intermolecular recognition site; other site 114615017797 dimerization interface [polypeptide binding]; other site 114615017798 Uncharacterized conserved protein, YhbC family [Function unknown]; Region: COG0782 114615017799 Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272 114615017800 Escherichia coli YfcE and related proteins, metallophosphatase domain; Region: MPP_YfcE; cd00841 114615017801 active site 114615017802 metal binding site [ion binding]; metal-binding site 114615017803 homotetramer interface [polypeptide binding]; other site 114615017804 Domain of unknown function (DUF4175); Region: DUF4175; pfam13779 114615017805 Domain of unknown function (DUF4175); Region: DUF4175; pfam13779 114615017806 Plasmid stabilisation system protein; Region: Plasmid_stabil; cl17483 114615017807 Domain of unknown function (DUF1902); Region: DUF1902; pfam08972 114615017808 Helix-turn-helix domain; Region: HTH_28; pfam13518 114615017809 putative transposase OrfB; Reviewed; Region: PHA02517 114615017810 HTH-like domain; Region: HTH_21; pfam13276 114615017811 Integrase core domain; Region: rve; pfam00665 114615017812 Integrase core domain; Region: rve_3; pfam13683 114615017813 N-acetyl-gamma-glutamyl-phosphate reductase; Validated; Region: argC; PRK00436 114615017814 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 114615017815 diaminopimelate decarboxylase; Region: lysA; TIGR01048 114615017816 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Diaminopimelate Decarboxylase; Region: PLPDE_III_DapDC; cd06828 114615017817 active site 114615017818 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 114615017819 substrate binding site [chemical binding]; other site 114615017820 catalytic residues [active] 114615017821 dimer interface [polypeptide binding]; other site 114615017822 argininosuccinate lyase; Provisional; Region: PRK00855 114615017823 Argininosuccinate lyase (argininosuccinase, ASAL); Region: Argininosuccinate_lyase; cd01359 114615017824 active sites [active] 114615017825 tetramer interface [polypeptide binding]; other site 114615017826 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966 114615017827 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 114615017828 catalytic residues [active] 114615017829 3-hydroxybutyryl-CoA dehydrogenase; Validated; Region: PRK07530 114615017830 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 114615017831 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 114615017832 Electron transfer flavoprotein, alpha subunit [Energy production and conversion]; Region: FixB; COG2025 114615017833 The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_alpha; cd01715 114615017834 Electron transfer flavoprotein FAD-binding domain; Region: ETF_alpha; pfam00766 114615017835 The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_beta; cd01714 114615017836 Ligand binding site [chemical binding]; other site 114615017837 Electron transfer flavoprotein domain; Region: ETF; pfam01012 114615017838 Cobalamin adenosyltransferase; Region: Cob_adeno_trans; pfam01923 114615017839 Hypoxia induced protein conserved region; Region: HIG_1_N; pfam04588 114615017840 Virulence factor BrkB; Region: Virul_fac_BrkB; pfam03631 114615017841 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 114615017842 dimer interface [polypeptide binding]; other site 114615017843 phosphorylation site [posttranslational modification] 114615017844 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 114615017845 ATP binding site [chemical binding]; other site 114615017846 Mg2+ binding site [ion binding]; other site 114615017847 G-X-G motif; other site 114615017848 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 114615017849 active site 114615017850 phosphorylation site [posttranslational modification] 114615017851 intermolecular recognition site; other site 114615017852 dimerization interface [polypeptide binding]; other site 114615017853 glutamyl-Q tRNA(Asp) synthetase; Reviewed; Region: PRK05710 114615017854 active site 114615017855 HIGH motif; other site 114615017856 nucleotide binding site [chemical binding]; other site 114615017857 active site 114615017858 KMSKS motif; other site 114615017859 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 114615017860 endonuclease III; Region: ENDO3c; smart00478 114615017861 minor groove reading motif; other site 114615017862 helix-hairpin-helix signature motif; other site 114615017863 substrate binding pocket [chemical binding]; other site 114615017864 active site 114615017865 Protein of unknown function (DUF2855); Region: DUF2855; pfam11017 114615017866 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 114615017867 SdiA-regulated; Region: SdiA-regulated; cd09971 114615017868 NHL repeat; Region: NHL; pfam01436 114615017869 Restriction endonuclease [Defense mechanisms]; Region: McrA; COG1403 114615017870 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 114615017871 active site 114615017872 ABC transporter, ATP-binding subunit, PQQ-dependent alcohol dehydrogenase system; Region: PQQ_ABC_ATP; TIGR03864 114615017873 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 114615017874 Walker A/P-loop; other site 114615017875 ATP binding site [chemical binding]; other site 114615017876 Q-loop/lid; other site 114615017877 ABC transporter signature motif; other site 114615017878 Walker B; other site 114615017879 D-loop; other site 114615017880 H-loop/switch region; other site 114615017881 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 114615017882 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 114615017883 Beta-carotene ketolase/oxygenase (CrtW, also known as CrtO), the carotenoid astaxanthin biosynthetic enzyme, initially catalyzes the addition of two keto groups to carbons C4 and C4' of beta-carotene. Carotenoids are important natural pigments...; Region: CrtW_beta-carotene-ketolase; cd03513 114615017884 putative di-iron ligands [ion binding]; other site 114615017885 Trans-Isoprenyl Diphosphate Synthases, head-to-head; Region: Trans_IPPS_HH; cd00683 114615017886 active site lid residues [active] 114615017887 substrate binding pocket [chemical binding]; other site 114615017888 catalytic residues [active] 114615017889 substrate-Mg2+ binding site; other site 114615017890 aspartate-rich region 1; other site 114615017891 aspartate-rich region 2; other site 114615017892 phytoene desaturase; Region: crtI_fam; TIGR02734 114615017893 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 114615017894 lycopene cyclase; Region: lycopene_cycl; TIGR01789 114615017895 lycopene cyclase family protein; Region: carotene-cycl; TIGR01790 114615017896 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 114615017897 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 114615017898 substrate binding pocket [chemical binding]; other site 114615017899 chain length determination region; other site 114615017900 substrate-Mg2+ binding site; other site 114615017901 catalytic residues [active] 114615017902 aspartate-rich region 1; other site 114615017903 active site lid residues [active] 114615017904 aspartate-rich region 2; other site 114615017905 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 114615017906 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 114615017907 metal binding site [ion binding]; metal-binding site 114615017908 active site 114615017909 I-site; other site 114615017910 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 114615017911 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270 114615017912 active site 114615017913 ATP binding site [chemical binding]; other site 114615017914 hypothetical protein; Reviewed; Region: PRK09588 114615017915 Uncharacterized protein family UPF0027; Region: UPF0027; cl17455 114615017916 RF-1 domain; Region: RF-1; cl17422 114615017917 Protein chain release factor B [Translation, ribosomal structure and biogenesis]; Region: PrfB; COG1186 114615017918 putative chaperone; Provisional; Region: PRK11678 114615017919 Escherichia coli YegD, a putative chaperone protein, and related proteins; Region: YegD_like; cd10231 114615017920 nucleotide binding site [chemical binding]; other site 114615017921 putative NEF/HSP70 interaction site [polypeptide binding]; other site 114615017922 SBD interface [polypeptide binding]; other site 114615017923 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 114615017924 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 114615017925 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 114615017926 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 114615017927 DNA binding site [nucleotide binding] 114615017928 Predicted integral membrane protein [Function unknown]; Region: COG5616 114615017929 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 114615017930 TPR motif; other site 114615017931 Flp/Fap pilin component; Region: Flp_Fap; cl01585 114615017932 tyramine oxidase; Provisional; Region: tynA; PRK11504 114615017933 Copper amine oxidase, N2 domain; Region: Cu_amine_oxidN2; pfam02727 114615017934 Copper amine oxidase, N3 domain; Region: Cu_amine_oxidN3; pfam02728 114615017935 Copper amine oxidase, enzyme domain; Region: Cu_amine_oxid; pfam01179 114615017936 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 114615017937 Beta-lactamase; Region: Beta-lactamase; pfam00144 114615017938 Helix-turn-helix domain; Region: HTH_18; pfam12833 114615017939 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 114615017940 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK08276 114615017941 acyl-activating enzyme (AAE) consensus motif; other site 114615017942 Bacterial Bile acid CoA ligases and similar proteins; Region: BACL_like; cd05929 114615017943 putative AMP binding site [chemical binding]; other site 114615017944 putative active site [active] 114615017945 acyl-activating enzyme (AAE) consensus motif; other site 114615017946 putative CoA binding site [chemical binding]; other site 114615017947 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 114615017948 FAD binding domain; Region: FAD_binding_4; pfam01565 114615017949 Domain of unknown function (DUF4383); Region: DUF4383; pfam14325 114615017950 Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]; Region: DegQ; COG0265 114615017951 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 114615017952 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 114615017953 protein binding site [polypeptide binding]; other site 114615017954 Predicted esterase [General function prediction only]; Region: COG0400 114615017955 Predicted periplasmic protein [Function unknown]; Region: COG3904 114615017956 DsbA family, Com1-like subfamily; composed of proteins similar to Com1, a 27-kDa outer membrane-associated immunoreactive protein originally found in both acute and chronic disease strains of the pathogenic bacteria Coxiella burnetti. It contains a CXXC...; Region: DsbA_Com1_like; cd03023 114615017957 DSBA-like thioredoxin domain; Region: DSBA; pfam01323 114615017958 catalytic residues [active] 114615017959 membrane protein AbrB duplication; Region: Gneg_AbrB_dup; TIGR03082 114615017960 Putative ammonia monooxygenase; Region: AmoA; pfam05145 114615017961 membrane protein AbrB duplication; Region: Gneg_AbrB_dup; TIGR03082 114615017962 Disulfide bond formation protein DsbB; Region: DsbB; pfam02600 114615017963 Domain of unknown function (DUF4261); Region: DUF4261; pfam14080 114615017964 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 114615017965 putative substrate translocation pore; other site 114615017966 Major Facilitator Superfamily; Region: MFS_1; pfam07690 114615017967 Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531 114615017968 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 114615017969 NAD synthetase; Reviewed; Region: nadE; PRK02628 114615017970 Glutamine aminotransferase (GAT, glutaminase) domain of glutamine-dependent NAD synthetases (class 7 and 8 nitrilases); Region: GAT_Gln-NAD-synth; cd07570 114615017971 multimer interface [polypeptide binding]; other site 114615017972 active site 114615017973 catalytic triad [active] 114615017974 protein interface 1 [polypeptide binding]; other site 114615017975 NAD+ synthase is a homodimer, which catalyzes the final step in de novo nicotinamide adenine dinucleotide (NAD+) biosynthesis, an amide transfer from either ammonia or glutamine to nicotinic acid adenine dinucleotide (NaAD). The conversion of NaAD to NAD...; Region: NAD_synthase; cd00553 114615017976 homodimer interface [polypeptide binding]; other site 114615017977 NAD binding pocket [chemical binding]; other site 114615017978 ATP binding pocket [chemical binding]; other site 114615017979 Mg binding site [ion binding]; other site 114615017980 active-site loop [active] 114615017981 atypical (a) SDRs, subgroup 4; Region: SDR_a4; cd05266 114615017982 putative NAD(P) binding site [chemical binding]; other site 114615017983 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 114615017984 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 114615017985 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 114615017986 WHG domain; Region: WHG; pfam13305 114615017987 short chain dehydrogenase; Provisional; Region: PRK07478 114615017988 classical (c) SDRs; Region: SDR_c; cd05233 114615017989 NAD(P) binding site [chemical binding]; other site 114615017990 active site 114615017991 alpha-ketoglutarate decarboxylase; Reviewed; Region: kgd; PRK12270 114615017992 Dioxygenases related to 2-nitropropane dioxygenase [General function prediction only]; Region: COG2070 114615017993 2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730 114615017994 FMN binding site [chemical binding]; other site 114615017995 substrate binding site [chemical binding]; other site 114615017996 putative catalytic residue [active] 114615017997 acyl-CoA synthetase; Validated; Region: PRK06188 114615017998 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 114615017999 Bacterial Bile acid CoA ligases and similar proteins; Region: BACL_like; cd05929 114615018000 acyl-activating enzyme (AAE) consensus motif; other site 114615018001 acyl-activating enzyme (AAE) consensus motif; other site 114615018002 putative AMP binding site [chemical binding]; other site 114615018003 putative active site [active] 114615018004 putative CoA binding site [chemical binding]; other site 114615018005 This CD represents a family of iron-molybdenum cluster-binding proteins that includes NifB, NifX, and NifY, all of which are involved in the synthesis of an iron-molybdenum cofactor (FeMo-co) that binds the active site of the dinitrogenase enzyme. This...; Region: NifX_NifB; cl00252 114615018006 Four helix bundle sensory module for signal transduction; Region: 4HB_MCP_1; pfam12729 114615018007 ligand binding domain of Tar- and Tsr-related chemoreceptors; Region: Tar_Tsr_LBD; cl00144 114615018008 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 114615018009 dimerization interface [polypeptide binding]; other site 114615018010 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 114615018011 dimer interface [polypeptide binding]; other site 114615018012 Methyl-accepting chemotaxis protein (MCP) signalling domain; Region: MCPsignal; pfam00015 114615018013 putative CheW interface [polypeptide binding]; other site 114615018014 Thioesterase-like superfamily; Region: 4HBT_3; pfam13622 114615018015 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 114615018016 active site 1 [active] 114615018017 active site 2 [active] 114615018018 cell division topological specificity factor MinE; Reviewed; Region: minE; PRK00296 114615018019 Septum formation inhibitor-activating ATPase [Cell division and chromosome partitioning]; Region: MinD; COG2894 114615018020 Bacterial cell division requires the formation of a septum at mid-cell. The site is determined by the min operon products MinC, MinD and MinE. MinC is a nonspecific inhibitor of the septum protein FtsZ. MinE is the supressor of MinC. MinD plays a pivotal...; Region: MinD; cd02036 114615018021 Switch I; other site 114615018022 Switch II; other site 114615018023 septum formation inhibitor; Reviewed; Region: minC; PRK05177 114615018024 Septum formation inhibitor MinC, C-terminal domain; Region: MinC_C; pfam03775 114615018025 Type I periplasmic binding domain of uncharacterized extracellular ligand-binding proteins; Region: PBP1_STKc_like; cd06326 114615018026 Periplasmic binding protein; Region: Peripla_BP_6; pfam13458 114615018027 putative ligand binding site [chemical binding]; other site 114615018028 Periplasmic binding protein; Region: Peripla_BP_6; pfam13458 114615018029 Type I periplasmic binding domain of uncharacterized extracellular ligand-binding proteins; Region: PBP1_STKc_like; cd06326 114615018030 putative ligand binding site [chemical binding]; other site 114615018031 Periplasmic binding protein; Region: Peripla_BP_6; pfam13458 114615018032 Type I periplasmic binding domain of uncharacterized extracellular ligand-binding proteins; Region: PBP1_STKc_like; cd06326 114615018033 putative ligand binding site [chemical binding]; other site 114615018034 Dioxygenases related to 2-nitropropane dioxygenase [General function prediction only]; Region: COG2070 114615018035 2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730 114615018036 FMN binding site [chemical binding]; other site 114615018037 substrate binding site [chemical binding]; other site 114615018038 putative catalytic residue [active] 114615018039 Predicted membrane protein [Function unknown]; Region: COG1238 114615018040 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in Escherichia coli phosphoribosyl-ATP pyrophosphohydrolase (HisIE or PRATP-PH) and its homologs; Region: NTP-PPase_HisIE_like; cd11534 114615018041 metal binding site [ion binding]; metal-binding site 114615018042 NMT1/THI5 like; Region: NMT1; pfam09084 114615018043 TRAP transporter solute receptor, TAXI family; Region: TRAP_TAXI; TIGR02122 114615018044 cyclic beta-1,2-glucan ABC transporter; Provisional; Region: PRK13657 114615018045 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 114615018046 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 114615018047 Walker A/P-loop; other site 114615018048 ATP binding site [chemical binding]; other site 114615018049 Q-loop/lid; other site 114615018050 ABC transporter signature motif; other site 114615018051 Walker B; other site 114615018052 D-loop; other site 114615018053 H-loop/switch region; other site 114615018054 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872 114615018055 D-alanyl-D-alanine carboxypeptidase; Region: Peptidase_S11; pfam00768 114615018056 Long-chain-fatty-acid--CoA ligase; Validated; Region: PRK07059 114615018057 Prokaryotic long-chain fatty acid CoA synthetases similar to Escherichia coli FadD; Region: FC-FACS_FadD_like; cd05936 114615018058 acyl-activating enzyme (AAE) consensus motif; other site 114615018059 putative AMP binding site [chemical binding]; other site 114615018060 putative active site [active] 114615018061 putative CoA binding site [chemical binding]; other site 114615018062 Peroxiredoxin (PRX) family, PRX5-like subfamily; members are similar to the human protein, PRX5, a homodimeric TRX peroxidase, widely expressed in tissues and found cellularly in mitochondria, peroxisomes and the cytosol. The cellular location of PRX5...; Region: PRX5_like; cd03013 114615018063 catalytic triad [active] 114615018064 dimer interface [polypeptide binding]; other site 114615018065 RNase HI family found mainly in prokaryotes; Region: RNase_HI_prokaryote_like; cd09278 114615018066 RNA/DNA hybrid binding site [nucleotide binding]; other site 114615018067 active site 114615018068 Putative homoserine kinase type II (protein kinase fold) [General function prediction only]; Region: COG2334 114615018069 Homoserine Kinase, type II. Homoserine kinase is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs), RIO kinases, actin-fragmin kinase (AFK), and...; Region: HomoserineK_II; cd05153 114615018070 putative active site [active] 114615018071 putative substrate binding site [chemical binding]; other site 114615018072 ATP binding site [chemical binding]; other site 114615018073 4-Hydroxy-3-methylbut-2-enyl diphosphate reductase IspH [Lipid metabolism]; Region: lytB; COG0761 114615018074 4-hydroxy-3-methylbut-2-enyl diphosphate reductase; Reviewed; Region: ispH; PRK01045 114615018075 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3820 114615018076 Outer membrane protein W [Cell envelope biogenesis, outer membrane]; Region: OmpW; COG3047 114615018077 propionyl-CoA synthetase; Provisional; Region: prpE; PRK10524 114615018078 Propionyl-CoA synthetase (PrpE); Region: PrpE; cd05967 114615018079 acyl-activating enzyme (AAE) consensus motif; other site 114615018080 putative AMP binding site [chemical binding]; other site 114615018081 putative active site [active] 114615018082 putative CoA binding site [chemical binding]; other site 114615018083 TPR repeat; Region: TPR_11; pfam13414 114615018084 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 114615018085 binding surface 114615018086 TPR motif; other site 114615018087 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK07231 114615018088 classical (c) SDRs; Region: SDR_c; cd05233 114615018089 NAD(P) binding site [chemical binding]; other site 114615018090 active site 114615018091 Domain of unknown function (DUF1850); Region: DUF1850; pfam08905 114615018092 TRAP transporter, 4TM/12TM fusion protein; Region: TRAP_fused; TIGR02123 114615018093 DctM-like transporters; Region: DctM; pfam06808 114615018094 TRAP transporter solute receptor, TAXI family; Region: TRAP_TAXI; TIGR02122 114615018095 TRAP-type uncharacterized transport system, periplasmic component [General function prediction only]; Region: Imp; COG2358 114615018096 Endostatin-like domain; the angiogenesis inhibitor endostatin is a C-terminal fragment of collagen XV/XVIII, a proteoglycan/collagen found in vessel walls and basement membranes; this domain has a compact globular fold similar to that of C-type lectins; Region: Endostatin-like; cl00181 114615018097 Coenzyme A pyrophosphatase (CoAse), a member of the Nudix hydrolase superfamily, functions to catalyze the elimination of oxidized inactive CoA, which can inhibit CoA-utilizing enzymes. The need of CoAses mainly arises under conditions of oxidative...; Region: CoAse; cd03426 114615018098 putative active site [active] 114615018099 putative CoA binding site [chemical binding]; other site 114615018100 nudix motif; other site 114615018101 metal binding site [ion binding]; metal-binding site 114615018102 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 114615018103 CoenzymeA binding site [chemical binding]; other site 114615018104 subunit interaction site [polypeptide binding]; other site 114615018105 PHB binding site; other site 114615018106 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 114615018107 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 114615018108 active site 114615018109 catalytic tetrad [active] 114615018110 StaR_like; a well-conserved protein found in bacteria, plants, and animals. A family member from Streptomyces toyocaensis, StaR is part of a gene cluster involved in the biosynthesis of glycopeptide antibiotics (GPAs), specifically A47934. It has been...; Region: StaR_like; cd05804 114615018111 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084 114615018112 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 114615018113 Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006 114615018114 A family including aminopeptidase P, aminopeptidase M, and prolidase. Also known as metallopeptidase family M24. This family of enzymes is able to cleave amido-, imido- and amidino-containing bonds. Members exibit relatively narrow substrate specificity...; Region: APP_MetAP; cd01066 114615018115 active site 114615018116 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 114615018117 DNA binding site [nucleotide binding] 114615018118 Transcriptional regulators [Transcription]; Region: PurR; COG1609 114615018119 domain linker motif; other site 114615018120 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 114615018121 dimerization interface [polypeptide binding]; other site 114615018122 ligand binding site [chemical binding]; other site 114615018123 N-acyl-D-aspartate/D-glutamate deacylase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3653 114615018124 D-aminoacylases (N-acyl-D-Amino acid amidohydrolases) catalyze the hydrolysis of N-acyl-D-amino acids to produce the corresponding D-amino acids, which are used as intermediates in the synthesis of pesticides, bioactive peptides, and antibiotics; Region: D-aminoacylase; cd01297 114615018125 active site 114615018126 putative substrate binding pocket [chemical binding]; other site 114615018127 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 114615018128 formaldehyde dehydrogenase (FDH)-like; Region: FDH_like_ADH2; cd08286 114615018129 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 114615018130 catalytic Zn binding site [ion binding]; other site 114615018131 structural Zn binding site [ion binding]; other site 114615018132 NAD(P) binding site [chemical binding]; other site 114615018133 glycogen synthase; Provisional; Region: PRK14099 114615018134 This family is most closely related to the GT1 family of glycosyltransferases. Glycogen synthase catalyzes the formation and elongation of the alpha-1,4-glucose backbone using ADP-glucose, the second and key step of glycogen biosynthesis. This family...; Region: GT1_Glycogen_synthase_DULL1_like; cd03791 114615018135 ADP-binding pocket [chemical binding]; other site 114615018136 homodimer interface [polypeptide binding]; other site 114615018137 glucose-1-phosphate adenylyltransferase; Provisional; Region: glgC; PRK00725 114615018138 ADP-glucose pyrophosphorylase is involved in the biosynthesis of glycogen or starch; Region: ADP_Glucose_PP; cd02508 114615018139 ligand binding site; other site 114615018140 oligomer interface; other site 114615018141 Glucose-1-phosphate adenylyltransferase, C-terminal Left-handed parallel beta helix (LbH) domain: Glucose-1-phosphate adenylyltransferase is also known as ADP-glucose synthase or ADP-glucose pyrophosphorylase. It catalyzes the first committed and...; Region: LbH_G1P_AT_C; cd04651 114615018142 dimer interface [polypeptide binding]; other site 114615018143 N-terminal domain interface [polypeptide binding]; other site 114615018144 sulfate 1 binding site; other site 114615018145 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 114615018146 Fructokinases (FRKs) mainly from bacteria and plants are enzymes with high specificity for fructose, as are all FRKs, but they catalyzes the conversion of fructose to fructose-6-phosphate, which is an entry point into glycolysis via conversion into...; Region: bac_FRK; cd01167 114615018147 putative substrate binding site [chemical binding]; other site 114615018148 putative ATP binding site [chemical binding]; other site 114615018149 Yersinia Pseudotuberculosis carbohydrate kinase-like subgroup; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_YpCarbK_like; cd07782 114615018150 FGGY-family pentulose kinase; Region: 5C_CHO_kinase; TIGR01315 114615018151 N- and C-terminal domain interface [polypeptide binding]; other site 114615018152 active site 114615018153 MgATP binding site [chemical binding]; other site 114615018154 catalytic site [active] 114615018155 metal binding site [ion binding]; metal-binding site 114615018156 carbohydrate binding site [chemical binding]; other site 114615018157 putative homodimer interface [polypeptide binding]; other site 114615018158 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 114615018159 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 114615018160 NAD(P) binding site [chemical binding]; other site 114615018161 active site 114615018162 ABC-type sugar transport systems, ATPase components [Carbohydrate transport and metabolism]; Region: MalK; COG3839 114615018163 The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301 114615018164 Walker A/P-loop; other site 114615018165 ATP binding site [chemical binding]; other site 114615018166 Q-loop/lid; other site 114615018167 ABC transporter signature motif; other site 114615018168 Walker B; other site 114615018169 D-loop; other site 114615018170 H-loop/switch region; other site 114615018171 TOBE domain; Region: TOBE_2; pfam08402 114615018172 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 114615018173 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 114615018174 dimer interface [polypeptide binding]; other site 114615018175 conserved gate region; other site 114615018176 putative PBP binding loops; other site 114615018177 ABC-ATPase subunit interface; other site 114615018178 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 114615018179 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 114615018180 dimer interface [polypeptide binding]; other site 114615018181 conserved gate region; other site 114615018182 putative PBP binding loops; other site 114615018183 ABC-ATPase subunit interface; other site 114615018184 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 114615018185 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 114615018186 Transcriptional regulator, contains sigma factor-related N-terminal domain [Transcription]; Region: DeoR; COG2390 114615018187 Putative sugar-binding domain; Region: Sugar-bind; pfam04198 114615018188 Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460 114615018189 Flagellar basal body rod protein [Cell motility and secretion]; Region: FlgC; COG1558 114615018190 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; cl15855 114615018191 Phospholipid methyltransferase; Region: PEMT; cl17370 114615018192 Domain of unknown function (DUF4149); Region: DUF4149; pfam13664 114615018193 bifunctional 3-demethylubiquinone-9 3-methyltransferase/ 2-octaprenyl-6-hydroxy phenol methylase; Provisional; Region: PRK05134 114615018194 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 114615018195 S-adenosylmethionine binding site [chemical binding]; other site 114615018196 Bacterial SH3 domain; Region: SH3_3; pfam08239 114615018197 Bacterial SH3 domain; Region: SH3_3; cl17532 114615018198 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054 114615018199 dimerization interface [polypeptide binding]; other site 114615018200 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 114615018201 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 114615018202 dimer interface [polypeptide binding]; other site 114615018203 putative CheW interface [polypeptide binding]; other site 114615018204 zinc-binding protein; Provisional; Region: PRK01343 114615018205 Maf-like protein; Region: Maf; pfam02545 114615018206 Nucleotide binding protein Maf. Maf has been implicated in inhibition of septum formation in eukaryotes, bacteria and archaea, but homologs in B.subtilis and S.cerevisiae are nonessential for cell division. Maf has been predicted to be a nucleotide- or...; Region: Maf; cd00555 114615018207 active site 114615018208 dimer interface [polypeptide binding]; other site 114615018209 Protein-tyrosine-phosphatase [Signal transduction mechanisms]; Region: Wzb; COG0394 114615018210 Low molecular weight phosphatase family; Region: LMWPc; cd00115 114615018211 active site 114615018212 hypothetical protein; Provisional; Region: PRK02853 114615018213 histidinol dehydrogenase; Region: hisD; TIGR00069 114615018214 Histidinol dehydrogenase, HisD, E.C 1.1.1.23. Histidinol dehydrogenase catalyzes the last two steps in the L-histidine biosynthesis pathway, which is conserved in bacteria, archaea, fungi, and plants. These last two steps are (i) the NAD-dependent...; Region: Histidinol_dh; cd06572 114615018215 NAD binding site [chemical binding]; other site 114615018216 dimerization interface [polypeptide binding]; other site 114615018217 product binding site; other site 114615018218 substrate binding site [chemical binding]; other site 114615018219 zinc binding site [ion binding]; other site 114615018220 catalytic residues [active] 114615018221 Protein of unknown function (DUF2948); Region: DUF2948; pfam11164 114615018222 UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Region: murA; TIGR01072 114615018223 UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555 114615018224 hinge; other site 114615018225 active site 114615018226 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 114615018227 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 114615018228 ligand binding site [chemical binding]; other site 114615018229 flexible hinge region; other site 114615018230 thioredoxin-disulfide reductase; Region: TRX_reduct; TIGR01292 114615018231 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 114615018232 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 114615018233 pyruvate dehydrogenase; Provisional; Region: PRK09124 114615018234 Pyrimidine (PYR) binding domain of POX; Region: TPP_PYR_POX; cd07039 114615018235 PYR/PP interface [polypeptide binding]; other site 114615018236 tetramer interface [polypeptide binding]; other site 114615018237 dimer interface [polypeptide binding]; other site 114615018238 TPP binding site [chemical binding]; other site 114615018239 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 114615018240 Thiamine pyrophosphate (TPP) family, Pyruvate oxidase (POX) subfamily, TPP-binding module; composed of proteins similar to Lactobacillus plantarum POX, which plays a key role in controlling acetate production under aerobic conditions. POX decarboxylates...; Region: TPP_POX; cd02014 114615018241 TPP-binding site [chemical binding]; other site 114615018242 Predicted P-loop ATPase [General function prediction only]; Region: COG4928 114615018243 KAP family P-loop domain; Region: KAP_NTPase; pfam07693 114615018244 Uncharacterized conserved protein [Function unknown]; Region: COG2128 114615018245 Carboxymuconolactone decarboxylase family; Region: CMD; pfam02627 114615018246 Short-chain alcohol dehydrogenase of unknown specificity [General function prediction only]; Region: COG4221 114615018247 classical (c) SDRs; Region: SDR_c; cd05233 114615018248 NAD(P) binding site [chemical binding]; other site 114615018249 active site 114615018250 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 114615018251 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_7; cd08512 114615018252 Mg2+ and Co2+ transporters [Inorganic ion transport and metabolism]; Region: CorA; COG0598 114615018253 Mycobacterium tuberculosis CorA-like subfamily; Region: MtCorA-like; cd12830 114615018254 oligomer interface [polypeptide binding]; other site 114615018255 metal binding site [ion binding]; metal-binding site 114615018256 metal binding site [ion binding]; metal-binding site 114615018257 putative Cl binding site [ion binding]; other site 114615018258 basic sphincter; other site 114615018259 hydrophobic gate; other site 114615018260 periplasmic entrance; other site 114615018261 histidine kinase; Provisional; Region: PRK13557 114615018262 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 114615018263 putative active site [active] 114615018264 heme pocket [chemical binding]; other site 114615018265 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 114615018266 dimer interface [polypeptide binding]; other site 114615018267 phosphorylation site [posttranslational modification] 114615018268 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 114615018269 ATP binding site [chemical binding]; other site 114615018270 Mg2+ binding site [ion binding]; other site 114615018271 G-X-G motif; other site 114615018272 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 114615018273 active site 114615018274 phosphorylation site [posttranslational modification] 114615018275 intermolecular recognition site; other site 114615018276 dimerization interface [polypeptide binding]; other site 114615018277 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 114615018278 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 114615018279 Transcriptional regulator [Transcription]; Region: LysR; COG0583 114615018280 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 114615018281 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 114615018282 dimerization interface [polypeptide binding]; other site 114615018283 putative beta-ketoacyl acyl carrier protein [ACP] reductase (BKR)-like, SDR; Region: BKR_like_SDR_like; cd05344 114615018284 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK05565 114615018285 putative NAD(P) binding site [chemical binding]; other site 114615018286 putative active site [active] 114615018287 Glutamine synthetase [Amino acid transport and metabolism]; Region: GlnA; COG0174 114615018288 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 114615018289 Rieske non-heme iron oxygenase (RO) family, Phthalate 4,5-dioxygenase (PhDO)-like subfamily, N-terminal Rieske domain of the oxygenase alpha subunit; composed of the oxygenase alpha subunits of PhDO and similar proteins including 3-chlorobenzoate 3; Region: Rieske_RO_Alpha_PhDO_like; cd03479 114615018290 Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638 114615018291 C-terminal catalytic domain of the oxygenase alpha subunit of dicamba O-demethylase and related aromatic ring hydroxylating dioxygenases; Region: RHO_alpha_C_DMO-like; cd08878 114615018292 alpha subunit interface [polypeptide binding]; other site 114615018293 active site 114615018294 substrate binding site [chemical binding]; other site 114615018295 Fe binding site [ion binding]; other site 114615018296 beta-ketoadipate pathway transcriptional regulators, PcaR/PcaU/PobR family; Region: pcaR_pcaU; TIGR02431 114615018297 helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346 114615018298 Bacterial transcriptional regulator; Region: IclR; pfam01614 114615018299 3-oxoadipate enol-lactonase; Region: protocat_pcaD; TIGR02427 114615018300 Novel bacterial esterase that cleaves esters on halogenated cyclic compounds; Region: Esterase_713_like; cl17303 114615018301 catalytic site [active] 114615018302 DNA-binding transcriptional regulator EnvR; Provisional; Region: PRK09975 114615018303 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 114615018304 Aerobic-type carbon monoxide dehydrogenase, small subunit CoxS/CutS homologs [Energy production and conversion]; Region: CoxS; COG2080 114615018305 2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_3; pfam13085 114615018306 [2Fe-2S] binding domain; Region: Fer2_2; pfam01799 114615018307 Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM/CutM homologs [Energy production and conversion]; Region: CoxM; COG1319 114615018308 CO dehydrogenase flavoprotein C-terminal domain; Region: CO_deh_flav_C; smart01092 114615018309 Aerobic-type carbon monoxide dehydrogenase, large subunit CoxL/CutL homologs [Energy production and conversion]; Region: CoxL; COG1529 114615018310 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; smart01008 114615018311 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 114615018312 Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840 114615018313 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 114615018314 dimerization interface [polypeptide binding]; other site 114615018315 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 114615018316 dimer interface [polypeptide binding]; other site 114615018317 putative CheW interface [polypeptide binding]; other site 114615018318 PilZ domain; Region: PilZ; pfam07238 114615018319 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 114615018320 dimerization interface [polypeptide binding]; other site 114615018321 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 114615018322 dimer interface [polypeptide binding]; other site 114615018323 putative CheW interface [polypeptide binding]; other site 114615018324 Opacity protein and related surface antigens [Cell envelope biogenesis, outer membrane]; Region: COG3637 114615018325 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 114615018326 dimerization interface [polypeptide binding]; other site 114615018327 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 114615018328 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 114615018329 dimer interface [polypeptide binding]; other site 114615018330 putative CheW interface [polypeptide binding]; other site 114615018331 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 114615018332 pyridoxal phosphate-dependent acyltransferase, putative; Region: gly_Cac_T_rel; TIGR01825 114615018333 KBL_like; this family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to serine palmitoyltransferase (SPT), 5-aminolevulinate synthase (ALAS); Region: KBL_like; cd06454 114615018334 substrate-cofactor binding pocket; other site 114615018335 pyridoxal 5'-phosphate binding site [chemical binding]; other site 114615018336 catalytic residue [active] 114615018337 Na+/proline symporter [Amino acid transport and metabolism / General function prediction only]; Region: PutP; COG0591 114615018338 Na binding site [ion binding]; other site 114615018339 PAS fold; Region: PAS_7; pfam12860 114615018340 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 114615018341 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 114615018342 dimer interface [polypeptide binding]; other site 114615018343 phosphorylation site [posttranslational modification] 114615018344 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 114615018345 ATP binding site [chemical binding]; other site 114615018346 Mg2+ binding site [ion binding]; other site 114615018347 G-X-G motif; other site 114615018348 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 114615018349 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 114615018350 active site 114615018351 phosphorylation site [posttranslational modification] 114615018352 intermolecular recognition site; other site 114615018353 dimerization interface [polypeptide binding]; other site 114615018354 Cupin; Region: Cupin_6; pfam12852 114615018355 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 114615018356 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 114615018357 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 114615018358 Carboxymuconolactone decarboxylase family; Region: CMD; pfam02627 114615018359 Transcriptional regulator [Transcription]; Region: LysR; COG0583 114615018360 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 114615018361 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 114615018362 dimerization interface [polypeptide binding]; other site 114615018363 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 114615018364 Domain of Unknown Function with PDB structure (DUF3857); Region: DUF3857; pfam12969 114615018365 Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305 114615018366 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 114615018367 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 114615018368 active site 114615018369 phosphorylation site [posttranslational modification] 114615018370 intermolecular recognition site; other site 114615018371 dimerization interface [polypeptide binding]; other site 114615018372 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 114615018373 DNA binding residues [nucleotide binding] 114615018374 dimerization interface [polypeptide binding]; other site 114615018375 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 114615018376 putative substrate translocation pore; other site 114615018377 Uncharacterized protein family UPF0047; Region: UPF0047; pfam01894 114615018378 2-hydroxychromene-2-carboxylate isomerase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: NahD; COG3917 114615018379 DsbA family, 2-hydroxychromene-2-carboxylate (HCCA) isomerase subfamily; HCCA isomerase is a glutathione (GSH) dependent enzyme involved in the naphthalene catabolic pathway. It converts HCCA, a hemiketal formed spontaneously after ring cleavage of 1; Region: DsbA_HCCA_Iso; cd03022 114615018380 putative catalytic residue [active] 114615018381 Putative F0F1-ATPase subunit (ATPase_gene1); Region: ATPase_gene1; cl09754 114615018382 F0F1-type ATP synthase, subunit a [Energy production and conversion]; Region: AtpB; COG0356 114615018383 F0F1 ATP synthase subunit A; Validated; Region: PRK05815 114615018384 F0F1 ATP synthase subunit C; Validated; Region: PRK07558 114615018385 ATP synthase B/B' CF(0); Region: ATP-synt_B; cl17192 114615018386 F0F1-type ATP synthase, subunit b [Energy production and conversion]; Region: AtpF; COG0711 114615018387 F0F1 ATP synthase subunit B; Provisional; Region: PRK14475 114615018388 F0F1 ATP synthase subunit B; Validated; Region: PRK09173 114615018389 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 114615018390 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 114615018391 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 114615018392 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 114615018393 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 114615018394 Threonine synthase [Amino acid transport and metabolism]; Region: ThrC; COG0498 114615018395 Threonine synthase catalyzes the final step of threonine biosynthesis. The conversion of O-phosphohomoserine into threonine and inorganic phosphate is pyridoxal 5'-phosphate dependent. The Thr-synth_1 CD includes members from higher plants; Region: Thr-synth_2; cd01560 114615018396 pyridoxal 5'-phosphate binding site [chemical binding]; other site 114615018397 catalytic residue [active] 114615018398 Putative heavy-metal-binding; Region: YbjQ_1; cl00426 114615018399 Carboxymuconolactone decarboxylase family; Region: CMD; cl00460 114615018400 Helix-Turn-Helix DNA binding domain of the MerR-like transcription regulators YyaN and YraB; Region: HTH_YyaN; cd01109 114615018401 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 114615018402 DNA binding residues [nucleotide binding] 114615018403 putative dimer interface [polypeptide binding]; other site 114615018404 SURF1 superfamily. Surf1/Shy1 has been implicated in the posttranslational steps of the biogenesis of the mitochondrially-encoded Cox1 subunit of cytochrome c oxidase (complex IV). Cytochrome c oxidase (complex IV), the terminal electron-transferring...; Region: SURF1; cd06662 114615018405 Protein of unknown function (DUF983); Region: DUF983; cl02211 114615018406 Cytochrome c oxidase subunit III. Cytochrome c oxidase (CcO), the terminal oxidase in the respiratory chains of eukaryotes and most bacteria, is a multi-chain transmembrane protein located in the inner membrane of mitochondria and the cell membrane of...; Region: Cyt_c_Oxidase_III; cd01665 114615018407 Subunit III/VIIa interface [polypeptide binding]; other site 114615018408 Phospholipid binding site [chemical binding]; other site 114615018409 Subunit I/III interface [polypeptide binding]; other site 114615018410 Subunit III/VIb interface [polypeptide binding]; other site 114615018411 Subunit III/VIa interface; other site 114615018412 Subunit III/Vb interface [polypeptide binding]; other site 114615018413 cytochrome C oxidase assembly protein; Provisional; Region: PRK05089 114615018414 protoheme IX farnesyltransferase; Provisional; Region: PRK04375 114615018415 UbiA prenyltransferase family; Region: UbiA; pfam01040 114615018416 Heme/copper-type cytochrome/quinol oxidases, subunit 1 [Energy production and conversion]; Region: CyoB; COG0843 114615018417 Cytochrome C oxidase subunit I. Cytochrome c oxidase (CcO), the terminal oxidase in the respiratory chains of eukaryotes and most bacteria, is a multi-chain transmembrane protein located in the inner membrane of mitochondria and the cell membrane of...; Region: Cyt_c_Oxidase_I; cd01663 114615018418 Subunit I/III interface [polypeptide binding]; other site 114615018419 D-pathway; other site 114615018420 Subunit I/VIIc interface [polypeptide binding]; other site 114615018421 Subunit I/IV interface [polypeptide binding]; other site 114615018422 Subunit I/II interface [polypeptide binding]; other site 114615018423 Low-spin heme (heme a) binding site [chemical binding]; other site 114615018424 Subunit I/VIIa interface [polypeptide binding]; other site 114615018425 Subunit I/VIa interface [polypeptide binding]; other site 114615018426 Dimer interface; other site 114615018427 Putative water exit pathway; other site 114615018428 Binuclear center (heme a3/CuB) [ion binding]; other site 114615018429 K-pathway; other site 114615018430 Subunit I/Vb interface [polypeptide binding]; other site 114615018431 Putative proton exit pathway; other site 114615018432 Subunit I/VIb interface; other site 114615018433 Subunit I/VIc interface [polypeptide binding]; other site 114615018434 Electron transfer pathway; other site 114615018435 Subunit I/VIIIb interface [polypeptide binding]; other site 114615018436 Subunit I/VIIb interface [polypeptide binding]; other site 114615018437 Cytochrome C oxidase subunit II, transmembrane domain; Region: COX2_TM; pfam02790 114615018438 cytochrome c oxidase subunit II; Provisional; Region: COX2; MTH00154 114615018439 Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; pfam00116 114615018440 Invasion associated locus B (IalB) protein; Region: IalB; pfam06776 114615018441 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 114615018442 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 114615018443 protease TldD; Provisional; Region: tldD; PRK10735 114615018444 signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227 114615018445 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 114615018446 Catalytic site [active] 114615018447 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 114615018448 Bacterial protein of unknown function (DUF925); Region: DUF925; pfam06042 114615018449 Cytochrome c biogenesis protein [Posttranslational modification, protein turnover, chaperones]; Region: CcdA; COG0785 114615018450 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 114615018451 catalytic residues [active] 114615018452 PAN domain; Region: PAN_4; pfam14295 114615018453 putative binding site; other site 114615018454 PAN/APPLE-like domain; present in N-terminal (N) domains of plasminogen/ hepatocyte growth factor proteins, plasma prekallikrein/coagulation factor XI and microneme antigen proteins, plant receptor-like protein kinases, and various nematode and leech...; Region: PAN_APPLE; cl00112 114615018455 glutamate--cysteine ligase; Region: PLN02611 114615018456 MarR family; Region: MarR_2; pfam12802 114615018457 Transcriptional regulators [Transcription]; Region: MarR; COG1846 114615018458 glutathionine S-transferase; Provisional; Region: PRK10542 114615018459 GST_N family, Class Beta subfamily; GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of endogenous and xenobiotic alkylating agents, including carcinogens; Region: GST_N_Beta; cd03057 114615018460 C-terminal domain interface [polypeptide binding]; other site 114615018461 GSH binding site (G-site) [chemical binding]; other site 114615018462 dimer interface [polypeptide binding]; other site 114615018463 C-terminal, alpha helical domain of Class Beta Glutathione S-transferases; Region: GST_C_Beta; cd03188 114615018464 N-terminal domain interface [polypeptide binding]; other site 114615018465 dimer interface [polypeptide binding]; other site 114615018466 substrate binding pocket (H-site) [chemical binding]; other site 114615018467 Plasmid stabilization system protein [General function prediction only]; Region: ParE; COG3668 114615018468 Putative addiction module component; Region: Unstab_antitox; cl09921 114615018469 multifunctional fatty acid oxidation complex subunit alpha; Reviewed; Region: fadJ; PRK11154 114615018470 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 114615018471 substrate binding site [chemical binding]; other site 114615018472 oxyanion hole (OAH) forming residues; other site 114615018473 trimer interface [polypeptide binding]; other site 114615018474 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 114615018475 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 114615018476 acetyl-CoA acetyltransferase; Validated; Region: PRK08242 114615018477 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 114615018478 dimer interface [polypeptide binding]; other site 114615018479 active site 114615018480 acyl-CoA dehydrogenase; Provisional; Region: PTZ00456 114615018481 Acyl-CoA dehydrogenase N terminal; Region: AcylCoA_DH_N; pfam12418 114615018482 Putative acyl-CoA dehydrogenases similar to fadE5; Region: ACAD_fadE5; cd01153 114615018483 FAD binding site [chemical binding]; other site 114615018484 substrate binding site [chemical binding]; other site 114615018485 catalytic residues [active] 114615018486 Acetyl-CoA dehydrogenase C-terminal like; Region: Acyl-CoA_dh_C; pfam12806 114615018487 SnoaL-like domain; Region: SnoaL_2; pfam12680 114615018488 Predicted transcriptional regulators [Transcription]; Region: COG1695 114615018489 Transcriptional regulator PadR-like family; Region: PadR; pfam03551 114615018490 Virulence activator alpha C-term; Region: Vir_act_alpha_C; pfam10400 114615018491 FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790 114615018492 Sel1-like repeats; Region: SEL1; smart00671 114615018493 Sel1-like repeats; Region: SEL1; smart00671 114615018494 Sel1-like repeats; Region: SEL1; smart00671 114615018495 Sel1-like repeats; Region: SEL1; smart00671 114615018496 Predicted periplasmic protein [Function unknown]; Region: COG3904 114615018497 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 114615018498 Putative transmembrane protein (Alph_Pro_TM); Region: Alph_Pro_TM; cl09826 114615018499 putative DMT superfamily transporter inner membrane protein; Provisional; Region: PRK11272 114615018500 EamA-like transporter family; Region: EamA; pfam00892 114615018501 EamA-like transporter family; Region: EamA; pfam00892 114615018502 Transcriptional regulator [Transcription]; Region: LysR; COG0583 114615018503 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 114615018504 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 114615018505 dimerization interface [polypeptide binding]; other site 114615018506 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 114615018507 Pyrococcus furiosus PF1019 and related proteins, metallophosphatase domain; Region: MPP_PF1019; cd07391 114615018508 putative active site [active] 114615018509 putative metal binding site [ion binding]; other site 114615018510 DEXH box helicase, DNA ligase-associated; Region: DEXH_lig_assoc; TIGR04121 114615018511 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 114615018512 ATP binding site [chemical binding]; other site 114615018513 putative Mg++ binding site [ion binding]; other site 114615018514 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 114615018515 nucleotide binding region [chemical binding]; other site 114615018516 ATP-binding site [chemical binding]; other site 114615018517 DEAD/H associated; Region: DEAD_assoc; pfam08494 114615018518 Type I periplasmic ligand-binding domain of uncharacterized ABC (ATPase Binding Cassette)-type active transport systems that are predicted to be involved in uptake of amino acids, peptides, or inorganic ions; Region: PBP1_ABC_ligand_binding_like_8; cd06343 114615018519 Periplasmic binding protein; Region: Peripla_BP_6; pfam13458 114615018520 putative ligand binding site [chemical binding]; other site 114615018521 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 114615018522 binding surface 114615018523 Predicted methyltransferase (contains TPR repeat) [General function prediction only]; Region: COG4976 114615018524 TPR motif; other site 114615018525 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 114615018526 S-adenosylmethionine binding site [chemical binding]; other site 114615018527 putative exonuclease, DNA ligase-associated; Region: Xnuc_lig_assoc; TIGR04122 114615018528 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 114615018529 Adenylation domain of putative bacterial ATP-dependent DNA ligases; Region: Adenylation_DNA_ligase_Bac1; cd07897 114615018530 DNA polymerase LigD, ligase domain; Region: NHEJ_ligase_lig; TIGR02779 114615018531 active site 114615018532 DNA binding site [nucleotide binding] 114615018533 The Oligonucleotide/oligosaccharide binding (OB)-fold domain of archaeal and bacterial ATP-dependent DNA ligases is a DNA-binding module that is part of the catalytic core unit; Region: OBF_DNA_ligase_Arch_LigB; cd07972 114615018534 DNA binding site [nucleotide binding] 114615018535 DNA-damage-inducible SOS response protein; Provisional; Region: PRK10367 114615018536 DinF and similar proteins, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_DinF_like; cd13136 114615018537 dihydroorotate dehydrogenase 2; Reviewed; Region: PRK05286 114615018538 Dihydroorotate dehydrogenase (DHOD) class 2. DHOD catalyzes the oxidation of (S)-dihydroorotate to orotate. This is the fourth step and the only redox reaction in the de novo biosynthesis of UMP, the precursor of all pyrimidine nucleotides. DHOD requires...; Region: DHOD_2_like; cd04738 114615018539 quinone interaction residues [chemical binding]; other site 114615018540 active site 114615018541 catalytic residues [active] 114615018542 FMN binding site [chemical binding]; other site 114615018543 substrate binding site [chemical binding]; other site 114615018544 Protein of unknown function (DUF952); Region: DUF952; pfam06108 114615018545 Carbonic anhydrase [Inorganic ion transport and metabolism]; Region: Cah; COG3338 114615018546 Carbonic anhydrase alpha, prokaryotic-like subfamily. Carbonic anhydrases (CAs) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism: a nucleophilic attack of a zinc-bound hydroxide ion on carbon...; Region: alpha_CA_prokaryotic_like; cd03124 114615018547 active site 114615018548 zinc binding site [ion binding]; other site 114615018549 lysyl-tRNA synthetase; Reviewed; Region: lysK; PRK00750 114615018550 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 114615018551 active site 114615018552 nucleotide binding site [chemical binding]; other site 114615018553 HIGH motif; other site 114615018554 KMSKS motif; other site 114615018555 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 114615018556 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 114615018557 substrate binding pocket [chemical binding]; other site 114615018558 membrane-bound complex binding site; other site 114615018559 hinge residues; other site 114615018560 Uncharacterized protein SCO1/SenC/PrrC, involved in biogenesis of respiratory and photosynthetic systems [General function prediction only]; Region: COG1999 114615018561 SCO (an acronym for Synthesis of Cytochrome c Oxidase) family; composed of proteins similar to Sco1, a membrane-anchored protein possessing a soluble domain with a TRX fold. Members of this family are required for the proper assembly of cytochrome c...; Region: SCO; cd02968 114615018562 Cu(I) binding site [ion binding]; other site 114615018563 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 114615018564 CoA binding site [chemical binding]; other site 114615018565 Transcriptional regulators [Transcription]; Region: PurR; COG1609 114615018566 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 114615018567 DNA binding site [nucleotide binding] 114615018568 domain linker motif; other site 114615018569 Ligand-binding domain of DNA transcription repressor GntR specific for gluconate, a member of the LacI-GalR family of bacterial transcription regulators; Region: PBP1_GntR; cd01575 114615018570 putative dimerization interface [polypeptide binding]; other site 114615018571 putative ligand binding site [chemical binding]; other site 114615018572 ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129 114615018573 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 114615018574 Walker A/P-loop; other site 114615018575 ATP binding site [chemical binding]; other site 114615018576 Q-loop/lid; other site 114615018577 ABC transporter signature motif; other site 114615018578 Walker B; other site 114615018579 D-loop; other site 114615018580 H-loop/switch region; other site 114615018581 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 114615018582 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 114615018583 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 114615018584 TM-ABC transporter signature motif; other site 114615018585 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 114615018586 Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407 114615018587 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3224 114615018588 SMP-30/Gluconolaconase/LRE-like region; Region: SGL; pfam08450 114615018589 3-hydroxyisobutyrate dehydrogenase; Region: HIBADH; TIGR01692 114615018590 gluconate 5-dehydrogenase; Provisional; Region: PRK07523 114615018591 gluconate 5-dehydrogenase (Ga5DH)-like, classical (c) SDRs; Region: Ga5DH-like_SDR_c; cd05347 114615018592 NADP binding site [chemical binding]; other site 114615018593 homodimer interface [polypeptide binding]; other site 114615018594 active site 114615018595 Methylated DNA-protein cysteine methyltransferase [DNA replication, recombination, and repair]; Region: Ada; COG0350 114615018596 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 114615018597 DNA binding site [nucleotide binding] 114615018598 active site 114615018599 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 114615018600 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 114615018601 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 114615018602 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_19; cd07262 114615018603 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 114615018604 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643 114615018605 hydrophobic ligand binding site; other site 114615018606 Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; Region: MATE_like_3; cd13148 114615018607 putative efflux protein, MATE family; Region: matE; TIGR00797 114615018608 2'-deoxycytidine 5'-triphosphate deaminase; Provisional; Region: PRK07559 114615018609 Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cl00493 114615018610 Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557 114615018611 trimer interface [polypeptide binding]; other site 114615018612 active site 114615018613 Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cl00493 114615018614 O-succinylhomoserine sulfhydrylase; Reviewed; Region: PRK07504 114615018615 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 114615018616 homodimer interface [polypeptide binding]; other site 114615018617 substrate-cofactor binding pocket; other site 114615018618 pyridoxal 5'-phosphate binding site [chemical binding]; other site 114615018619 catalytic residue [active] 114615018620 SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cd00229 114615018621 active site 114615018622 catalytic triad [active] 114615018623 oxyanion hole [active] 114615018624 Global regulator protein family; Region: CsrA; cl00670 114615018625 SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cd00229 114615018626 active site 114615018627 catalytic triad [active] 114615018628 oxyanion hole [active] 114615018629 OpgC protein; Region: OpgC_C; pfam10129 114615018630 CO2+/MG2+ efflux protein ApaG; Reviewed; Region: apaG; PRK05461 114615018631 Heat shock protein 33 (Hsp33): Cytosolic protein that acts as a molecular chaperone under oxidative conditions. In normal (reducing) cytosolic conditions, four conserved Cys residues are coordinated by a Zn ion. Under oxidative stress (such as heat...; Region: Hsp33; cd00498 114615018632 Hsp33-like chaperonin; Reviewed; Region: hslO; PRK00114 114615018633 dimerization interface [polypeptide binding]; other site 114615018634 domain crossover interface; other site 114615018635 redox-dependent activation switch; other site 114615018636 Domain of unknown function, appears to be related to a diverse group of endonucleases; Region: Endonuclease_DUF559; cd01038 114615018637 putative active site [active] 114615018638 ornithine carbamoyltransferase; Provisional; Region: PRK00779 114615018639 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 114615018640 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 114615018641 acetylornithine transaminase protein; Provisional; Region: argD; PRK01278 114615018642 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 114615018643 inhibitor-cofactor binding pocket; inhibition site 114615018644 pyridoxal 5'-phosphate binding site [chemical binding]; other site 114615018645 catalytic residue [active] 114615018646 GcrA cell cycle regulator; Region: GcrA; pfam07750 114615018647 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 114615018648 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 114615018649 dimer interface [polypeptide binding]; other site 114615018650 phosphorylation site [posttranslational modification] 114615018651 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 114615018652 ATP binding site [chemical binding]; other site 114615018653 Mg2+ binding site [ion binding]; other site 114615018654 G-X-G motif; other site 114615018655 Predicted integral membrane protein [Function unknown]; Region: COG0392 114615018656 Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885 114615018657 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 114615018658 ligand binding site [chemical binding]; other site 114615018659 Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726 114615018660 Catalytic NodB homology domain of the carbohydrate esterase 4 superfamily; Region: CE4_SF; cl15692 114615018661 Putative catalytic NodB homology domain of Mesorhizobium loti Mlr8448 protein and its bacterial homologs; Region: CE4_Mlr8448_like_5s; cd10968 114615018662 putative active site [active] 114615018663 gluconate 5-dehydrogenase; Provisional; Region: PRK08213 114615018664 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 114615018665 NAD(P) binding site [chemical binding]; other site 114615018666 active site 114615018667 Phenylacetic acid catabolic protein; Region: PaaA_PaaC; cl01346 114615018668 benzoyl-CoA-dihydrodiol lyase; Provisional; Region: PRK08184 114615018669 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 114615018670 substrate binding site [chemical binding]; other site 114615018671 oxyanion hole (OAH) forming residues; other site 114615018672 trimer interface [polypeptide binding]; other site 114615018673 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 114615018674 substrate binding site [chemical binding]; other site 114615018675 trimer interface [polypeptide binding]; other site 114615018676 oxyanion hole (OAH) forming residues; other site 114615018677 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 114615018678 benzoate-CoA ligase family; Region: benz_CoA_lig; TIGR02262 114615018679 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 114615018680 acyl-activating enzyme (AAE) consensus motif; other site 114615018681 AMP binding site [chemical binding]; other site 114615018682 active site 114615018683 CoA binding site [chemical binding]; other site 114615018684 anaerobic benzoate catabolism transcriptional regulator; Reviewed; Region: PRK08154 114615018685 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 114615018686 non-specific DNA binding site [nucleotide binding]; other site 114615018687 salt bridge; other site 114615018688 sequence-specific DNA binding site [nucleotide binding]; other site 114615018689 Shikimate kinase (SK) is the fifth enzyme in the shikimate pathway, a seven-step biosynthetic pathway which converts erythrose-4-phosphate to chorismic acid, found in bacteria, fungi and plants. Chorismic acid is a important intermediate in the synthesis...; Region: SK; cd00464 114615018690 ADP binding site [chemical binding]; other site 114615018691 magnesium binding site [ion binding]; other site 114615018692 putative shikimate binding site; other site 114615018693 agmatinase; Region: agmatinase; TIGR01230 114615018694 Agmatinase-like family; Region: Agmatinase-like; cd09990 114615018695 active site 114615018696 oligomer interface [polypeptide binding]; other site 114615018697 Mn binding site [ion binding]; other site 114615018698 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 114615018699 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 114615018700 Walker A/P-loop; other site 114615018701 ATP binding site [chemical binding]; other site 114615018702 Q-loop/lid; other site 114615018703 ABC transporter signature motif; other site 114615018704 Walker B; other site 114615018705 D-loop; other site 114615018706 H-loop/switch region; other site 114615018707 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 114615018708 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 114615018709 dimer interface [polypeptide binding]; other site 114615018710 conserved gate region; other site 114615018711 putative PBP binding loops; other site 114615018712 ABC-ATPase subunit interface; other site 114615018713 ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components [Inorganic ion transport and metabolism]; Region: TauA; COG0715 114615018714 ABC transporter periplasmic binding protein, urea carboxylase region; Region: ABC_peri_uca; TIGR03427 114615018715 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410 114615018716 ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224 114615018717 Walker A/P-loop; other site 114615018718 ATP binding site [chemical binding]; other site 114615018719 Q-loop/lid; other site 114615018720 ABC transporter signature motif; other site 114615018721 Walker B; other site 114615018722 D-loop; other site 114615018723 H-loop/switch region; other site 114615018724 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411 114615018725 ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219 114615018726 Walker A/P-loop; other site 114615018727 ATP binding site [chemical binding]; other site 114615018728 Q-loop/lid; other site 114615018729 ABC transporter signature motif; other site 114615018730 Walker B; other site 114615018731 D-loop; other site 114615018732 H-loop/switch region; other site 114615018733 ABC-type branched-chain amino acid transport system, permease component [Amino acid transport and metabolism]; Region: LivM; COG4177 114615018734 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 114615018735 TM-ABC transporter signature motif; other site 114615018736 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 114615018737 TM-ABC transporter signature motif; other site 114615018738 Periplasmic binding protein; Region: Peripla_BP_6; pfam13458 114615018739 Type I periplasmic binding component of active transport systems that are predicted to be involved in 2-nitrobenzoic acid degradation pathway; Region: PBP1_Nba_like; cd06359 114615018740 putative ligand binding site [chemical binding]; other site 114615018741 Periplasmic binding protein; Region: Peripla_BP_6; pfam13458 114615018742 Periplasmic solute-binding domain of active transport proteins that belong to the type I periplasmic binding fold protein family; Region: PBP1_SBP_like_1; cd06327 114615018743 putative ligand binding site [chemical binding]; other site 114615018744 Ferredoxin [Energy production and conversion]; Region: Fdx; COG0633 114615018745 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 114615018746 catalytic loop [active] 114615018747 iron binding site [ion binding]; other site 114615018748 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 114615018749 Cytochrome P450; Region: p450; cl12078 114615018750 Transcriptional regulators [Transcription]; Region: MarR; COG1846 114615018751 MarR family; Region: MarR_2; pfam12802 114615018752 NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252 114615018753 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 114615018754 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 114615018755 allophanate hydrolase; Provisional; Region: PRK08186 114615018756 Amidase; Region: Amidase; cl11426 114615018757 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3666 114615018758 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 114615018759 Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751 114615018760 Transcriptional regulators [Transcription]; Region: GntR; COG1802 114615018761 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 114615018762 DNA-binding site [nucleotide binding]; DNA binding site 114615018763 FCD domain; Region: FCD; pfam07729 114615018764 Protein of unknown function (DUF3225); Region: DUF3225; pfam11533 114615018765 amidase; Provisional; Region: PRK09201 114615018766 Amidase; Region: Amidase; pfam01425 114615018767 Protein of unknown function (DUF4089); Region: DUF4089; pfam13318 114615018768 ATPase components of various ABC-type transport systems, contain duplicated ATPase [General function prediction only]; Region: COG1123 114615018769 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 114615018770 Walker A/P-loop; other site 114615018771 ATP binding site [chemical binding]; other site 114615018772 Q-loop/lid; other site 114615018773 ABC transporter signature motif; other site 114615018774 Walker B; other site 114615018775 D-loop; other site 114615018776 H-loop/switch region; other site 114615018777 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; pfam08352 114615018778 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 114615018779 Walker A/P-loop; other site 114615018780 ATP binding site [chemical binding]; other site 114615018781 Q-loop/lid; other site 114615018782 ABC transporter signature motif; other site 114615018783 Walker B; other site 114615018784 D-loop; other site 114615018785 H-loop/switch region; other site 114615018786 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 114615018787 N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911 114615018788 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 114615018789 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 114615018790 dimer interface [polypeptide binding]; other site 114615018791 conserved gate region; other site 114615018792 putative PBP binding loops; other site 114615018793 ABC-ATPase subunit interface; other site 114615018794 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 114615018795 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 114615018796 dimer interface [polypeptide binding]; other site 114615018797 conserved gate region; other site 114615018798 putative PBP binding loops; other site 114615018799 ABC-ATPase subunit interface; other site 114615018800 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 114615018801 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_7; cd08512 114615018802 Caspase domain; Region: Peptidase_C14; pfam00656 114615018803 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cd05120 114615018804 active site 114615018805 ATP binding site [chemical binding]; other site 114615018806 Phosphotransferase enzyme family; Region: APH; pfam01636 114615018807 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270 114615018808 active site 114615018809 ATP binding site [chemical binding]; other site 114615018810 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 114615018811 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 114615018812 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 114615018813 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 114615018814 dimerization interface [polypeptide binding]; other site 114615018815 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 114615018816 ATP binding site [chemical binding]; other site 114615018817 Mg2+ binding site [ion binding]; other site 114615018818 G-X-G motif; other site 114615018819 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 114615018820 Domain of unknown function (DUF3369); Region: DUF3369; pfam11849 114615018821 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 114615018822 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 114615018823 dimer interface [polypeptide binding]; other site 114615018824 phosphorylation site [posttranslational modification] 114615018825 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 114615018826 ATP binding site [chemical binding]; other site 114615018827 Mg2+ binding site [ion binding]; other site 114615018828 G-X-G motif; other site 114615018829 osmolarity response regulator; Provisional; Region: ompR; PRK09468 114615018830 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 114615018831 active site 114615018832 phosphorylation site [posttranslational modification] 114615018833 intermolecular recognition site; other site 114615018834 dimerization interface [polypeptide binding]; other site 114615018835 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 114615018836 DNA binding site [nucleotide binding] 114615018837 RNA polymerase sigma factor; Provisional; Region: PRK12515 114615018838 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 114615018839 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 114615018840 DNA binding residues [nucleotide binding] 114615018841 Bacterial Cytochrome Ubiquinol Oxidase; Region: Bac_Ubq_Cox; pfam01654 114615018842 Cytochrome oxidase subunit II; Region: Cyto_ox_2; pfam02322 114615018843 cytochrome d ubiquinol oxidase subunit 2; Provisional; Region: PRK15003; cl12219 114615018844 Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376 114615018845 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 114615018846 Bacterial periplasmic substrate-binding proteins; Region: PBPb; smart00062 114615018847 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 114615018848 substrate binding pocket [chemical binding]; other site 114615018849 membrane-bound complex binding site; other site 114615018850 hinge residues; other site 114615018851 Secreted and surface protein containing fasciclin-like repeats [Cell envelope biogenesis, outer membrane]; Region: COG2335 114615018852 Fasciclin domain; Region: Fasciclin; pfam02469 114615018853 pimeloyl-CoA dehydrogenase, small subunit; Region: pimD_small; TIGR03203 114615018854 Acyl-CoA dehydrogenase; Region: ACAD; cd00567 114615018855 active site 114615018856 pimeloyl-CoA dehydrogenase, large subunit; Region: pimC_large; TIGR03204 114615018857 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 114615018858 active site 114615018859 Major Facilitator Superfamily; Region: MFS_1; pfam07690 114615018860 Serine proteases of the peptidase family S9A [Amino acid transport and metabolism]; Region: COG1505 114615018861 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 114615018862 Protein of unknown function (DUF938); Region: DUF938; pfam06080 114615018863 Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010 114615018864 Cytochrome c; Region: Cytochrom_C; pfam00034 114615018865 sulfur oxidation protein SoxY; Provisional; Region: PRK07474 114615018866 Sulfur oxidation protein SoxY; Region: SoxY; pfam13501 114615018867 Sulphur oxidation protein SoxZ; Region: SoxZ; pfam08770 114615018868 Cytochrome c [Energy production and conversion]; Region: COG3258 114615018869 Cytochrome c [Energy production and conversion]; Region: COG3258 114615018870 Thermus thermophilus SoxB and related proteins, N-terminal metallophosphatase domain; Region: MPP_SoxB_N; cd07411 114615018871 active site 114615018872 metal binding site [ion binding]; metal-binding site 114615018873 5'-nucleotidase/2',3'-cyclic phosphodiesterase and related esterases [Nucleotide transport and metabolism]; Region: UshA; COG0737 114615018874 5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872 114615018875 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 114615018876 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cl00125 114615018877 active site residue [active] 114615018878 choline dehydrogenase; Validated; Region: PRK02106 114615018879 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 114615018880 ABC transporter, substrate-binding protein, aliphatic sulfonates family; Region: SsuA_fam; TIGR01728 114615018881 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 114615018882 substrate binding pocket [chemical binding]; other site 114615018883 membrane-bound complex binding site; other site 114615018884 TRAP transporter solute receptor, TAXI family; Region: TRAP_TAXI; TIGR02122 114615018885 ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components [Inorganic ion transport and metabolism]; Region: TauA; COG0715 114615018886 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 114615018887 substrate binding pocket [chemical binding]; other site 114615018888 membrane-bound complex binding site; other site 114615018889 hinge residues; other site 114615018890 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 114615018891 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 114615018892 Walker A/P-loop; other site 114615018893 ATP binding site [chemical binding]; other site 114615018894 Q-loop/lid; other site 114615018895 ABC transporter signature motif; other site 114615018896 Walker B; other site 114615018897 D-loop; other site 114615018898 H-loop/switch region; other site 114615018899 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 114615018900 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 114615018901 dimer interface [polypeptide binding]; other site 114615018902 conserved gate region; other site 114615018903 putative PBP binding loops; other site 114615018904 ABC-ATPase subunit interface; other site 114615018905 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 114615018906 Major Facilitator Superfamily; Region: MFS_1; pfam07690 114615018907 N-acyl-D-aspartate/D-glutamate deacylase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3653 114615018908 D-aminoacylases (N-acyl-D-Amino acid amidohydrolases) catalyze the hydrolysis of N-acyl-D-amino acids to produce the corresponding D-amino acids, which are used as intermediates in the synthesis of pesticides, bioactive peptides, and antibiotics; Region: D-aminoacylase; cd01297 114615018909 active site 114615018910 putative substrate binding pocket [chemical binding]; other site 114615018911 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 114615018912 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 114615018913 D-galactonate transporter; Region: 2A0114; TIGR00893 114615018914 putative substrate translocation pore; other site 114615018915 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 114615018916 cobalt transport protein ATP-binding subunit; Region: cbiO; TIGR01166 114615018917 Walker A/P-loop; other site 114615018918 ATP binding site [chemical binding]; other site 114615018919 Q-loop/lid; other site 114615018920 ABC transporter signature motif; other site 114615018921 Walker B; other site 114615018922 D-loop; other site 114615018923 H-loop/switch region; other site 114615018924 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 114615018925 FtsX-like permease family; Region: FtsX; pfam02687 114615018926 Hydroxyneurosporene synthase (CrtC); Region: CrtC; cl12101 114615018927 MAPEG family; Region: MAPEG; pfam01124 114615018928 Periplasmic binding protein; Region: Peripla_BP_6; pfam13458 114615018929 Periplasmic solute-binding domain of active transport proteins that belong to the type I periplasmic binding fold protein family; Region: PBP1_SBP_like_1; cd06327 114615018930 putative ligand binding site [chemical binding]; other site 114615018931 acyl-CoA synthetase; Provisional; Region: PRK13391 114615018932 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 114615018933 Bacterial Bile acid CoA ligases and similar proteins; Region: BACL_like; cd05929 114615018934 acyl-activating enzyme (AAE) consensus motif; other site 114615018935 acyl-activating enzyme (AAE) consensus motif; other site 114615018936 putative AMP binding site [chemical binding]; other site 114615018937 putative active site [active] 114615018938 putative CoA binding site [chemical binding]; other site 114615018939 FOG: CBS domain [General function prediction only]; Region: COG0517 114615018940 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the BON (bacterial OsmY and nodulation domain) domain. BON is a putative phospholipid-binding domain found in a family of osmotic shock protection...; Region: CBS_pair_BON_assoc; cd04586 114615018941 FOG: CBS domain [General function prediction only]; Region: COG0517 114615018942 BON domain; Region: BON; pfam04972 114615018943 Cytochrome c; Region: Cytochrom_C; cl11414 114615018944 PAS domain S-box; Region: sensory_box; TIGR00229 114615018945 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 114615018946 putative active site [active] 114615018947 heme pocket [chemical binding]; other site 114615018948 PAS domain S-box; Region: sensory_box; TIGR00229 114615018949 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 114615018950 putative active site [active] 114615018951 heme pocket [chemical binding]; other site 114615018952 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920 114615018953 HWE histidine kinase; Region: HWE_HK; smart00911 114615018954 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 114615018955 active site 114615018956 phosphorylation site [posttranslational modification] 114615018957 intermolecular recognition site; other site 114615018958 dimerization interface [polypeptide binding]; other site 114615018959 Acetyl/propionyl-CoA carboxylase, alpha subunit [Lipid metabolism]; Region: COG4770 114615018960 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 114615018961 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786 114615018962 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; pfam02785 114615018963 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 114615018964 carboxyltransferase (CT) interaction site; other site 114615018965 biotinylation site [posttranslational modification]; other site 114615018966 Acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta) [Lipid metabolism]; Region: COG4799 114615018967 Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; cl17345 114615018968 Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; cl17345 114615018969 Prokaryotic protein of unknown function (DUF849); Region: DUF849; pfam05853 114615018970 Helix-turn-helix domain; Region: HTH_18; pfam12833 114615018971 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 114615018972 GST_N family, Saccharomyces cerevisiae GTT1-like subfamily; composed of predominantly uncharacterized proteins with similarity to the S. cerevisiae GST protein, GTT1, and the Schizosaccharomyces pombe GST-III. GSTs are cytosolic dimeric proteins involved...; Region: GST_N_GTT1_like; cd03046 114615018973 putative C-terminal domain interface [polypeptide binding]; other site 114615018974 putative GSH binding site (G-site) [chemical binding]; other site 114615018975 putative dimer interface [polypeptide binding]; other site 114615018976 C-terminal, alpha helical domain of the Glutathione S-transferase family; Region: GST_C_family; cl02776 114615018977 N-terminal domain interface [polypeptide binding]; other site 114615018978 dimer interface [polypeptide binding]; other site 114615018979 substrate binding pocket (H-site) [chemical binding]; other site 114615018980 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 114615018981 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 114615018982 active site 114615018983 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 114615018984 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 114615018985 active site 114615018986 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK06187 114615018987 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 114615018988 Bacterial Bile acid CoA ligases and similar proteins; Region: BACL_like; cd05929 114615018989 acyl-activating enzyme (AAE) consensus motif; other site 114615018990 acyl-activating enzyme (AAE) consensus motif; other site 114615018991 putative AMP binding site [chemical binding]; other site 114615018992 putative active site [active] 114615018993 putative CoA binding site [chemical binding]; other site 114615018994 Type I periplasmic ligand-binding domain of uncharacterized ABC (ATPase Binding Cassette)-type active transport systems that are predicted to be involved in uptake of amino acids, peptides, or inorganic ions; Region: PBP1_ABC_ligand_binding_like_8; cd06343 114615018995 Periplasmic binding protein; Region: Peripla_BP_6; pfam13458 114615018996 putative ligand binding site [chemical binding]; other site 114615018997 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 114615018998 sequence-specific DNA binding site [nucleotide binding]; other site 114615018999 salt bridge; other site 114615019000 marine proteobacterial sortase target protein; Region: marine_srt_targ; TIGR03788 114615019001 Vault protein inter-alpha-trypsin domain; Region: VIT; cl02699 114615019002 vWA_interalpha trypsin inhibitor (ITI): ITI is a glycoprotein composed of three polypeptides- two heavy chains and one light chain (bikunin). Bikunin confers the protease-inhibitor function while the heavy chains are involved in rendering stability to...; Region: vWA_interalpha_trypsin_inhibitor; cd01461 114615019003 metal ion-dependent adhesion site (MIDAS); other site 114615019004 Sortase D (SrtD) is a membrane transpeptidase found in gram-positive bacteria that anchors surface proteins to peptidoglycans of the bacterial cell wall envelope. This involves a transpeptidation reaction in which the surface protein substrate is cleaved...; Region: Sortase_D_4; cd05828 114615019005 active site 114615019006 catalytic site [active] 114615019007 Protein of unknown function (DUF1614); Region: DUF1614; pfam07758 114615019008 mce related protein; Region: MCE; pfam02470 114615019009 Cytochrome b562; Region: Cytochrom_B562; cl01546 114615019010 putative regulatory protein, FmdB family; Region: CxxC_CxxC_SSSS; TIGR02605 114615019011 Acetamidase/Formamidase family; Region: FmdA_AmdA; pfam03069 114615019012 urea ABC transporter, ATP-binding protein UrtE; Region: urea_trans_UrtE; TIGR03410 114615019013 ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224 114615019014 Walker A/P-loop; other site 114615019015 ATP binding site [chemical binding]; other site 114615019016 Q-loop/lid; other site 114615019017 ABC transporter signature motif; other site 114615019018 Walker B; other site 114615019019 D-loop; other site 114615019020 H-loop/switch region; other site 114615019021 urea ABC transporter, ATP-binding protein UrtD; Region: urea_trans_UrtD; TIGR03411 114615019022 ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219 114615019023 Walker A/P-loop; other site 114615019024 ATP binding site [chemical binding]; other site 114615019025 Q-loop/lid; other site 114615019026 ABC transporter signature motif; other site 114615019027 Walker B; other site 114615019028 D-loop; other site 114615019029 H-loop/switch region; other site 114615019030 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 114615019031 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 114615019032 TM-ABC transporter signature motif; other site 114615019033 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 114615019034 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 114615019035 TM-ABC transporter signature motif; other site 114615019036 Periplasmic binding protein; Region: Peripla_BP_6; pfam13458 114615019037 Periplasmic component (FmdD) of an active transport system for short-chain amides and urea (FmdDEF); Region: PBP1_FmdD_like; cd06355 114615019038 putative ligand binding site [chemical binding]; other site 114615019039 Permease for cytosine/purines, uracil, thiamine, allantoin; Region: Transp_cyt_pur; pfam02133 114615019040 Solute carrier families 5 and 6-like; solute binding domain; Region: SLC5-6-like_sbd; cl00456 114615019041 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 114615019042 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 114615019043 dimer interface [polypeptide binding]; other site 114615019044 phosphorylation site [posttranslational modification] 114615019045 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 114615019046 ATP binding site [chemical binding]; other site 114615019047 Mg2+ binding site [ion binding]; other site 114615019048 G-X-G motif; other site 114615019049 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 114615019050 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 114615019051 active site 114615019052 phosphorylation site [posttranslational modification] 114615019053 intermolecular recognition site; other site 114615019054 dimerization interface [polypeptide binding]; other site 114615019055 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 114615019056 Response regulator receiver domain; Region: Response_reg; pfam00072 114615019057 active site 114615019058 phosphorylation site [posttranslational modification] 114615019059 intermolecular recognition site; other site 114615019060 dimerization interface [polypeptide binding]; other site 114615019061 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 114615019062 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 114615019063 DNA binding residues [nucleotide binding] 114615019064 dimerization interface [polypeptide binding]; other site 114615019065 Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072 114615019066 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 114615019067 Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad...; Region: Tryp_SPc; cl00149 114615019068 active site 114615019069 substrate binding sites [chemical binding]; other site 114615019070 epoxide hydrolase N-terminal domain-like phosphatase; Region: HAD-1A3-hyp; TIGR02247 114615019071 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 114615019072 motif II; other site 114615019073 methylthioribose-1-phosphate isomerase; Reviewed; Region: mtnA; PRK05720 114615019074 S-methyl-5-thioribose-1-phosphate isomerase; Region: salvage_mtnA; TIGR00512 114615019075 5'-methylthioadenosine phosphorylase; Provisional; Region: PRK08931 114615019076 acyl carrier protein; Provisional; Region: PRK07081 114615019077 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 114615019078 Acyl-CoA dehydrogenase, N-terminal domain; Region: Acyl-CoA_dh_N; pfam02771 114615019079 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 114615019080 Gly_His_Pro_Ser_Thr_tRNA synthetase class II core domain. This domain is the core catalytic domain of tRNA synthetases of the subgroup containing glycyl, histidyl, prolyl, seryl and threonyl tRNA synthetases. It is primarily responsible for ATP-dependent...; Region: Gly_His_Pro_Ser_Thr_tRS_core; cd00670 114615019081 dimer interface [polypeptide binding]; other site 114615019082 motif 1; other site 114615019083 active site 114615019084 motif 2; other site 114615019085 motif 3; other site 114615019086 aminotransferase; Provisional; Region: PRK13356 114615019087 Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115 114615019088 homodimer interface [polypeptide binding]; other site 114615019089 substrate-cofactor binding pocket; other site 114615019090 pyridoxal 5'-phosphate binding site [chemical binding]; other site 114615019091 catalytic residue [active] 114615019092 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 114615019093 O-acetylhomoserine sulfhydrylase [Amino acid transport and metabolism]; Region: MET17; COG2873 114615019094 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 114615019095 homodimer interface [polypeptide binding]; other site 114615019096 substrate-cofactor binding pocket; other site 114615019097 pyridoxal 5'-phosphate binding site [chemical binding]; other site 114615019098 catalytic residue [active] 114615019099 homoserine O-succinyltransferase; Provisional; Region: PRK05368 114615019100 Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GAT_1; cl00020 114615019101 conserved cys residue [active] 114615019102 bifunctional proline dehydrogenase/pyrroline-5-carboxylate dehydrogenase; Reviewed; Region: PRK11904 114615019103 Proline dehydrogenase; Region: Pro_dh; pfam01619 114615019104 Delta(1)-pyrroline-5-carboxylate dehydrogenase, PutA; Region: ALDH_PutA-P5CDH; cd07125 114615019105 Glutamate binding site [chemical binding]; other site 114615019106 NAD binding site [chemical binding]; other site 114615019107 catalytic residues [active] 114615019108 Protein of unknown function (DUF763); Region: DUF763; pfam05559 114615019109 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447 114615019110 nudix motif; other site 114615019111 Cache is an extracellular domain that is predicted to have a role in small-molecule recognition in a wide range of proteins; Region: Cache_2; smart01049 114615019112 HAMP (Histidine kinases, Adenylyl cyclases, Methyl binding proteins, Phosphatases) domain; Region: HAMP; smart00304 114615019113 dimerization interface [polypeptide binding]; other site 114615019114 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 114615019115 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 114615019116 dimer interface [polypeptide binding]; other site 114615019117 putative CheW interface [polypeptide binding]; other site 114615019118 oxidoreductase, SDR family; Region: SDR_subfam_1; TIGR03971 114615019119 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 114615019120 NAD(P) binding site [chemical binding]; other site 114615019121 active site 114615019122 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 114615019123 Transcriptional regulator [Transcription]; Region: LysR; COG0583 114615019124 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 114615019125 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 114615019126 putative effector binding pocket; other site 114615019127 dimerization interface [polypeptide binding]; other site 114615019128 hypothetical protein; Provisional; Region: PRK06184 114615019129 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 114615019130 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 114615019131 autotransport protein MisL; Provisional; Region: PRK15313 114615019132 Protein of unknown function (DUF1629); Region: DUF1629; pfam07791 114615019133 type I secretion membrane fusion protein, HlyD family; Region: type_I_hlyD; TIGR01843 114615019134 Peptidase family M23; Region: Peptidase_M23; pfam01551 114615019135 HlyD family secretion protein; Region: HlyD_3; pfam13437 114615019136 Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the "double-glycine" leader peptides from the precursors of various bacteriocins (mostly non-lantibiotic); Region: Peptidase_C39_like; cl00296 114615019137 putative active site [active] 114615019138 type I secretion system ABC transporter, HlyB family; Region: type_I_sec_HlyB; TIGR01846 114615019139 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 114615019140 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 114615019141 Walker A/P-loop; other site 114615019142 ATP binding site [chemical binding]; other site 114615019143 Q-loop/lid; other site 114615019144 ABC transporter signature motif; other site 114615019145 Walker B; other site 114615019146 D-loop; other site 114615019147 H-loop/switch region; other site 114615019148 RTX toxin acyltransferase family; Region: HlyC; pfam02794 114615019149 putative Helix-turn-helix domain of transposase IS66; Region: HTH_Tnp_IS66; pfam13005 114615019150 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436 114615019151 Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050 114615019152 IS66 C-terminal element; Region: DDE_Tnp_IS66_C; pfam13817 114615019153 Protein of unknown function (DUF2924); Region: DUF2924; pfam11149 114615019154 integrase; Provisional; Region: PRK09692 114615019155 Bacteriophage P4 integrase. P4-like integrases are found in temperate bacteriophages, integrative plasmids, pathogenicity and symbiosis islands, and other mobile genetic elements. They share the same fold in their catalytic domain and the overall...; Region: INT_P4; cd00801 114615019156 active site 114615019157 Int/Topo IB signature motif; other site 114615019158 Helix-turn-helix domain; Region: HTH_36; pfam13730 114615019159 Trehalose-6-Phosphate Synthase (TPS) is a glycosyltransferase that catalyses the synthesis of alpha,alpha-1,1-trehalose-6-phosphate from glucose-6-phosphate using a UDP-glucose donor. It is a key enzyme in the trehalose synthesis pathway. Trehalose is a...; Region: GT1_TPS; cd03788 114615019160 active site 114615019161 homotetramer interface [polypeptide binding]; other site 114615019162 trehalose-6-phosphate phosphatase; Provisional; Region: PRK10187; cl17105 114615019163 HAD-superfamily hydrolase, subfamily IIB; Region: HAD-SF-IIB; TIGR01484 114615019164 benzoate transport; Region: 2A0115; TIGR00895 114615019165 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 114615019166 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 114615019167 dimerization interface [polypeptide binding]; other site 114615019168 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 114615019169 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 114615019170 dimer interface [polypeptide binding]; other site 114615019171 putative CheW interface [polypeptide binding]; other site 114615019172 Aerobic-type carbon monoxide dehydrogenase, small subunit CoxS/CutS homologs [Energy production and conversion]; Region: CoxS; COG2080 114615019173 [2Fe-2S] binding domain; Region: Fer2_2; pfam01799 114615019174 Aerobic-type carbon monoxide dehydrogenase, large subunit CoxL/CutL homologs [Energy production and conversion]; Region: CoxL; COG1529 114615019175 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; smart01008 114615019176 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 114615019177 Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM/CutM homologs [Energy production and conversion]; Region: CoxM; COG1319 114615019178 CO dehydrogenase flavoprotein C-terminal domain; Region: CO_deh_flav_C; smart01092 114615019179 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 114615019180 CoA-transferase family III; Region: CoA_transf_3; pfam02515 114615019181 4-hydroxyphenylpyruvate dioxygenase and related hemolysins [Amino acid transport and metabolism / General function prediction only]; Region: COG3185 114615019182 N-terminal domain of 4-hydroxyphenylpyruvate dioxygenase (HPPD) and hydroxymandelate Synthase (HmaS); Region: HPPD_N_like; cd08342 114615019183 dimer interface [polypeptide binding]; other site 114615019184 C-terminal domain of 4-hydroxyphenylpyruvate dioxygenase (HppD) and hydroxymandelate Synthase (HmaS); Region: HPPD_C_like; cd07250 114615019185 active site 114615019186 Fe binding site [ion binding]; other site 114615019187 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 114615019188 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 114615019189 putative DNA binding site [nucleotide binding]; other site 114615019190 putative Zn2+ binding site [ion binding]; other site 114615019191 AsnC family; Region: AsnC_trans_reg; pfam01037 114615019192 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3813 114615019193 Protein of unknown function (DUF1272); Region: DUF1272; pfam06906 114615019194 fumarylacetoacetase; Region: PLN02856 114615019195 Domain of unknown function (DUF1969); Region: DUF1969; pfam09298 114615019196 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557 114615019197 homogentisate 1,2-dioxygenase; Provisional; Region: PRK05341 114615019198 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 114615019199 Protein of unknown function (DUF2783); Region: DUF2783; pfam10932 114615019200 FAD-dependent oxidoreductase; Provisional; Region: PRK08132 114615019201 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 114615019202 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 114615019203 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 114615019204 MarR family; Region: MarR_2; pfam12802 114615019205 MarR family; Region: MarR_2; cl17246 114615019206 Cache domain; Region: Cache_1; pfam02743 114615019207 HAMP domain; Region: HAMP; pfam00672 114615019208 dimerization interface [polypeptide binding]; other site 114615019209 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 114615019210 GAF domain; Region: GAF; pfam01590 114615019211 Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114 114615019212 cyclase homology domain; Region: CHD; cd07302 114615019213 nucleotidyl binding site; other site 114615019214 metal binding site [ion binding]; metal-binding site 114615019215 dimer interface [polypeptide binding]; other site 114615019216 AsmA family; Region: AsmA; pfam05170 114615019217 AsmA-like C-terminal region; Region: AsmA_2; pfam13502 114615019218 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 114615019219 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 114615019220 ligand binding site [chemical binding]; other site 114615019221 flexible hinge region; other site 114615019222 Crp-like helix-turn-helix domain; Region: HTH_Crp_2; pfam13545 114615019223 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; pfam13231 114615019224 Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841 114615019225 Membrane-fusion protein [Cell envelope biogenesis, outer membrane]; Region: AcrA; COG0845 114615019226 Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404 114615019227 lipoyl-biotinyl attachment site [posttranslational modification]; other site 114615019228 HlyD family secretion protein; Region: HlyD_3; pfam13437 114615019229 Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885 114615019230 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 114615019231 ligand binding site [chemical binding]; other site 114615019232 Caspase domain; Region: Peptidase_C14; pfam00656 114615019233 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 114615019234 TPR repeat; Region: TPR_11; pfam13414 114615019235 binding surface 114615019236 TPR motif; other site 114615019237 TPR repeat; Region: TPR_11; pfam13414 114615019238 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 114615019239 Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376 114615019240 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 114615019241 HlyD family secretion protein; Region: HlyD_3; pfam13437 114615019242 Caspase domain; Region: Peptidase_C14; pfam00656 114615019243 Staphylococcal nuclease homologues; Region: SNc; smart00318 114615019244 Catalytic site; other site 114615019245 Staphylococcal nuclease homologues. SNase homologues are found in bacteria, archaea, and eukaryotes. They contain no disufide bonds; Region: SNc; cl00140 114615019246 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 114615019247 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 114615019248 catalytic residue [active] 114615019249 Protease II [Amino acid transport and metabolism]; Region: PtrB; COG1770 114615019250 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 114615019251 hypothetical protein; Validated; Region: PRK08245 114615019252 dihydroxy-acid dehydratase; Provisional; Region: PRK13016 114615019253 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 114615019254 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 114615019255 putative PBP binding loops; other site 114615019256 ABC-ATPase subunit interface; other site 114615019257 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 114615019258 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 114615019259 Walker A/P-loop; other site 114615019260 ATP binding site [chemical binding]; other site 114615019261 Q-loop/lid; other site 114615019262 ABC transporter signature motif; other site 114615019263 Walker B; other site 114615019264 D-loop; other site 114615019265 H-loop/switch region; other site 114615019266 ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components [Inorganic ion transport and metabolism]; Region: TauA; COG0715 114615019267 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cl17432 114615019268 Transcriptional regulators [Transcription]; Region: GntR; COG1802 114615019269 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 114615019270 DNA-binding site [nucleotide binding]; DNA binding site 114615019271 FCD domain; Region: FCD; pfam07729 114615019272 Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840 114615019273 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 114615019274 dimer interface [polypeptide binding]; other site 114615019275 putative CheW interface [polypeptide binding]; other site 114615019276 Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840 114615019277 HAMP domain; Region: HAMP; pfam00672 114615019278 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 114615019279 dimer interface [polypeptide binding]; other site 114615019280 putative CheW interface [polypeptide binding]; other site 114615019281 Response regulator receiver domain; Region: Response_reg; pfam00072 114615019282 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 114615019283 active site 114615019284 phosphorylation site [posttranslational modification] 114615019285 intermolecular recognition site; other site 114615019286 dimerization interface [polypeptide binding]; other site 114615019287 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 114615019288 HAMP domain; Region: HAMP; pfam00672 114615019289 PAS domain S-box; Region: sensory_box; TIGR00229 114615019290 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 114615019291 putative active site [active] 114615019292 heme pocket [chemical binding]; other site 114615019293 PAS domain S-box; Region: sensory_box; TIGR00229 114615019294 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 114615019295 putative active site [active] 114615019296 heme pocket [chemical binding]; other site 114615019297 PAS domain S-box; Region: sensory_box; TIGR00229 114615019298 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 114615019299 putative active site [active] 114615019300 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 114615019301 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 114615019302 dimer interface [polypeptide binding]; other site 114615019303 phosphorylation site [posttranslational modification] 114615019304 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 114615019305 ATP binding site [chemical binding]; other site 114615019306 Mg2+ binding site [ion binding]; other site 114615019307 G-X-G motif; other site 114615019308 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 114615019309 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 114615019310 active site 114615019311 phosphorylation site [posttranslational modification] 114615019312 intermolecular recognition site; other site 114615019313 dimerization interface [polypeptide binding]; other site 114615019314 Response regulator [Signal transduction mechanisms]; Region: TtrR; COG4566 114615019315 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 114615019316 active site 114615019317 phosphorylation site [posttranslational modification] 114615019318 intermolecular recognition site; other site 114615019319 dimerization interface [polypeptide binding]; other site 114615019320 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 114615019321 DNA binding residues [nucleotide binding] 114615019322 dimerization interface [polypeptide binding]; other site 114615019323 Response regulator receiver domain; Region: Response_reg; pfam00072 114615019324 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 114615019325 active site 114615019326 phosphorylation site [posttranslational modification] 114615019327 intermolecular recognition site; other site 114615019328 dimerization interface [polypeptide binding]; other site 114615019329 Methylase of chemotaxis methyl-accepting proteins [Cell motility and secretion / Signal transduction mechanisms]; Region: CheR; COG1352 114615019330 CheR methyltransferase, all-alpha domain; Region: CheR_N; pfam03705 114615019331 CheR methyltransferase, SAM binding domain; Region: CheR; pfam01739 114615019332 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 114615019333 Response regulator receiver domain; Region: Response_reg; pfam00072 114615019334 active site 114615019335 phosphorylation site [posttranslational modification] 114615019336 intermolecular recognition site; other site 114615019337 dimerization interface [polypeptide binding]; other site 114615019338 CheW-like domain. CheW proteins are part of the chemotaxis signalling mechanism in bacteria. CheW interacts with the methyl accepting chemotaxis proteins (MCPs) and relays signals to CheY, which affects flageller rotation. This family includes CheW and...; Region: CheW_like; cl00256 114615019339 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 114615019340 putative binding surface; other site 114615019341 active site 114615019342 Chemotaxis protein histidine kinase and related kinases [Cell motility and secretion / Signal transduction mechanisms]; Region: CheA; COG0643 114615019343 Signal transducing histidine kinase, homodimeric domain; Region: H-kinase_dim; pfam02895 114615019344 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 114615019345 ATP binding site [chemical binding]; other site 114615019346 Mg2+ binding site [ion binding]; other site 114615019347 G-X-G motif; other site 114615019348 CheA regulatory domain; CheA is a histidine protein kinase present in bacteria and archea. Activated by the chemotaxis receptor a histidine phosphoryl group from CheA is passed directly to an aspartate in the response regulator CheY. This signalling...; Region: CheA_reg; cd00731 114615019349 CheW-like domain; Region: CheW; pfam01584 114615019350 Response regulator receiver domain; Region: Response_reg; pfam00072 114615019351 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 114615019352 active site 114615019353 phosphorylation site [posttranslational modification] 114615019354 intermolecular recognition site; other site 114615019355 dimerization interface [polypeptide binding]; other site 114615019356 flagellar biosynthesis repressor FlbT; Reviewed; Region: flbT; PRK12791 114615019357 flagellin; Reviewed; Region: PRK12688 114615019358 flagellin; Reviewed; Region: PRK12688 114615019359 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 114615019360 dimer interface [polypeptide binding]; other site 114615019361 phosphorylation site [posttranslational modification] 114615019362 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 114615019363 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 114615019364 Crp-like helix-turn-helix domain; Region: HTH_Crp_2; pfam13545 114615019365 chemotaxis regulatory protein CheY; Provisional; Region: PRK10610 114615019366 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 114615019367 active site 114615019368 phosphorylation site [posttranslational modification] 114615019369 intermolecular recognition site; other site 114615019370 dimerization interface [polypeptide binding]; other site 114615019371 Response regulator receiver domain; Region: Response_reg; pfam00072 114615019372 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 114615019373 active site 114615019374 phosphorylation site [posttranslational modification] 114615019375 intermolecular recognition site; other site 114615019376 dimerization interface [polypeptide binding]; other site 114615019377 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 114615019378 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 114615019379 dimer interface [polypeptide binding]; other site 114615019380 phosphorylation site [posttranslational modification] 114615019381 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 114615019382 ATP binding site [chemical binding]; other site 114615019383 Mg2+ binding site [ion binding]; other site 114615019384 G-X-G motif; other site 114615019385 Response regulator receiver domain; Region: Response_reg; pfam00072 114615019386 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 114615019387 active site 114615019388 phosphorylation site [posttranslational modification] 114615019389 intermolecular recognition site; other site 114615019390 dimerization interface [polypeptide binding]; other site 114615019391 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 114615019392 putative binding surface; other site 114615019393 active site 114615019394 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 114615019395 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 114615019396 DNA binding residues [nucleotide binding] 114615019397 dimerization interface [polypeptide binding]; other site 114615019398 indolepyruvate/phenylpyruvate decarboxylase, Azospirillum family; Region: indol_phenyl_DC; TIGR03394 114615019399 Pyrimidine (PYR) binding domain of thiamine pyrophosphate (TPP)-dependent enzymes; Region: TPP_enzyme_PYR; cl11410 114615019400 PYR/PP interface [polypeptide binding]; other site 114615019401 dimer interface [polypeptide binding]; other site 114615019402 TPP binding site [chemical binding]; other site 114615019403 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 114615019404 Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cl01629 114615019405 TPP-binding site [chemical binding]; other site 114615019406 lipoxygenase; Region: PLN02337 114615019407 Bacterial transglutaminase-like cysteine proteinase BTLCP; Region: BTLCP; cl17596 114615019408 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 114615019409 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 114615019410 P-loop; other site 114615019411 Magnesium ion binding site [ion binding]; other site 114615019412 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 114615019413 This family is most closely related to the GT1 family of glycosyltransferases. ExpC in Rhizobium meliloti has been shown to be involved in the biosynthesis of galactoglucan (exopolysaccharide II); Region: GT1_ExpC_like; cd03818 114615019414 putative ADP-binding pocket [chemical binding]; other site 114615019415 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 114615019416 Subfamily of Glycosyltransferase Family GT2 of unknown function; Region: GT_2_like_c; cd04186 114615019417 Probable Catalytic site; other site 114615019418 metal-binding site 114615019419 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 114615019420 Subfamily of Glycosyltransferase Family GT2 of unknown function; Region: GT_2_like_c; cd04186 114615019421 Probable Catalytic site; other site 114615019422 metal-binding site 114615019423 dTDP-6-deoxy-L-lyxo-4-hexulose reductase and related proteins, extended (e) SDRs; Region: dTDP_HR_like_SDR_e; cd05254 114615019424 RmlD substrate binding domain; Region: RmlD_sub_bind; pfam04321 114615019425 NADP binding site [chemical binding]; other site 114615019426 active site 114615019427 putative substrate binding site [chemical binding]; other site 114615019428 dTDP-4-dehydrorhamnose 3,5-epimerase; Region: dTDP_sugar_isom; pfam00908 114615019429 G1P_TT_short is the short form of glucose-1-phosphate thymidylyltransferase; Region: G1P_TT_short; cd02538 114615019430 glucose-1-phosphate thymidylyltransferase, short form; Region: rmlA; TIGR01207 114615019431 substrate binding site; other site 114615019432 tetramer interface; other site 114615019433 dTDP-D-glucose 4,6-dehydratase [Cell envelope biogenesis, outer membrane]; Region: RfbB; COG1088 114615019434 dTDP-D-glucose 4,6-dehydratase, extended (e) SDRs; Region: dTDP_GD_SDR_e; cd05246 114615019435 NAD binding site [chemical binding]; other site 114615019436 substrate binding site [chemical binding]; other site 114615019437 homodimer interface [polypeptide binding]; other site 114615019438 active site 114615019439 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 114615019440 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 114615019441 active site 114615019442 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 114615019443 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 114615019444 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 114615019445 FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790 114615019446 Sel1-like repeats; Region: SEL1; smart00671 114615019447 FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790 114615019448 Sel1-like repeats; Region: SEL1; smart00671 114615019449 Sel1-like repeats; Region: SEL1; smart00671 114615019450 Sel1-like repeats; Region: SEL1; smart00671 114615019451 FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790 114615019452 Sel1-like repeats; Region: SEL1; smart00671 114615019453 Sel1-like repeats; Region: SEL1; smart00671 114615019454 Sel1-like repeats; Region: SEL1; smart00671 114615019455 Sel1-like repeats; Region: SEL1; smart00671 114615019456 type I secretion membrane fusion protein, HlyD family; Region: type_I_hlyD; TIGR01843 114615019457 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 114615019458 HlyD family secretion protein; Region: HlyD_3; pfam13437 114615019459 ABC-type bacteriocin/lantibiotic exporters, contain an N-terminal double-glycine peptidase domain [Defense mechanisms]; Region: SunT; COG2274 114615019460 Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the "double-glycine" leader peptides from the precursors of various bacteriocins (mostly non-lantibiotic); Region: Peptidase_C39_like; cl00296 114615019461 putative active site [active] 114615019462 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 114615019463 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 114615019464 Walker A/P-loop; other site 114615019465 ATP binding site [chemical binding]; other site 114615019466 Q-loop/lid; other site 114615019467 ABC transporter signature motif; other site 114615019468 Walker B; other site 114615019469 D-loop; other site 114615019470 H-loop/switch region; other site 114615019471 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4627 114615019472 Methyltransferase domain; Region: Methyltransf_23; pfam13489 114615019473 Peptidase M10 serralysin C terminal; Region: Peptidase_M10_C; pfam08548 114615019474 Peptidase M10 serralysin C terminal; Region: Peptidase_M10_C; pfam08548 114615019475 Peptidase M10 serralysin C terminal; Region: Peptidase_M10_C; pfam08548 114615019476 Peptidase M10 serralysin C terminal; Region: Peptidase_M10_C; pfam08548 114615019477 Peptidase M10 serralysin C terminal; Region: Peptidase_M10_C; pfam08548 114615019478 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 114615019479 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 114615019480 Alginate Lyase A1-III; enzymatically depolymerizes alginate, a complex copolymer of beta-D-mannuronate and alpha-L-guluronate, by cleaving the beta-(1,4) glycosidic bond; Region: AlgLyase; cl00179 114615019481 Heparinase II/III-like protein; Region: Hepar_II_III; pfam07940 114615019482 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 114615019483 2-desacetyl-2-hydroxyethyl bacteriochlorophyllide and other MDR family members; Region: 2-desacetyl-2-hydroxyethyl_bacteriochlorophyllide_; cd08255 114615019484 putative NAD(P) binding site [chemical binding]; other site 114615019485 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 114615019486 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 114615019487 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 114615019488 Sugar-binding cellulase-like; Region: Cellulase-like; pfam12876 114615019489 This family is most closely related to the GT1 family of glycosyltransferases. wbuB in E. coli is involved in the biosynthesis of the O26 O-antigen. It has been proposed to function as an N-acetyl-L-fucosamine (L-FucNAc) transferase; Region: GT1_wbuB_like; cd03794 114615019490 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 114615019491 nucleotide sugar dehydrogenase; Region: NDP-sugDHase; TIGR03026 114615019492 UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984 114615019493 UDP binding domain; Region: UDPG_MGDP_dh_C; smart00984 114615019494 Methyltransferase domain; Region: Methyltransf_23; pfam13489 114615019495 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 114615019496 S-adenosylmethionine binding site [chemical binding]; other site 114615019497 Methylase involved in ubiquinone/menaquinone biosynthesis [Coenzyme metabolism]; Region: UbiE; COG2226 114615019498 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 114615019499 S-adenosylmethionine binding site [chemical binding]; other site 114615019500 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 114615019501 Polysaccharide biosynthesis protein; Region: Polysacc_synt_3; pfam13440 114615019502 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 114615019503 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 114615019504 Methyltransferase domain; Region: Methyltransf_23; pfam13489 114615019505 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 114615019506 S-adenosylmethionine binding site [chemical binding]; other site 114615019507 Chain length determinant protein; Region: Wzz; cl15801 114615019508 exopolysaccharide transport protein family; Region: eps_transp_fam; TIGR01005 114615019509 Syntaxin N-terminus domain; syntaxins are nervous system-specific proteins implicated in the docking of synaptic vesicles with the presynaptic plasma membrane; they are a family of receptors for intracellular transport vesicles; each target membrane may...; Region: SynN; cl00143 114615019510 interdomain interaction site; other site 114615019511 nSec1 interaction sites; other site 114615019512 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 114615019513 O-Antigen ligase; Region: Wzy_C; pfam04932 114615019514 Periplasmic protein involved in polysaccharide export, contains SLBB domain of b-grasp fold [Cell wall/membrane/envelope biogenesis]; Region: Wza; COG1596 114615019515 Polysaccharide biosynthesis/export protein; Region: Poly_export; pfam02563 114615019516 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 114615019517 phosphoprotein phosphatases of the metallophosphatase superfamily, metallophosphatase domain; Region: MPP_PPP_family; cd00144 114615019518 active site 114615019519 metal binding site [ion binding]; metal-binding site 114615019520 Undecaprenyl-phosphate glucose phosphotransferase; Region: WcaJ_sugtrans; TIGR03023 114615019521 Bacterial sugar transferase; Region: Bac_transf; pfam02397 114615019522 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cl17393 114615019523 DNA-binding interface [nucleotide binding]; DNA binding site 114615019524 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 114615019525 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 114615019526 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 114615019527 This family is most closely related to the GT1 family of glycosyltransferases. wlbH in Bordetella parapertussis has been shown to be required for the biosynthesis of a trisaccharide that, when attached to the B. pertussis lipopolysaccharide (LPS) core; Region: GT1_wlbH_like; cd03798 114615019528 Putative catalytic NodB homology domain of PgaB, IcaB, and similar proteins which consist of a deformed (beta/alpha)8 barrel fold with 5- or 6-strands; Region: CE4_NodB_like_5s_6s; cd10918 114615019529 putative active site [active] 114615019530 putative metal binding site [ion binding]; other site 114615019531 Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326 114615019532 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 114615019533 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 114615019534 Uncharacterized protein involved in exopolysaccharide biosynthesis [Cell envelope biogenesis, outer membrane]; Region: GumC; COG3206 114615019535 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Mrp; COG0489 114615019536 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 114615019537 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 114615019538 This family is most closely related to the GT1 family of glycosyltransferases. wbaZ in Salmonella enterica has been shown to possess the mannosyl transferase activity. The members of this family are found in certain bacteria and Archaea; Region: GT1_wbaZ_like; cd03804 114615019539 putative ADP-binding pocket [chemical binding]; other site 114615019540 Protein of unknown function (DUF2848); Region: DUF2848; pfam11010 114615019541 Protein of unknown function (DUF3422); Region: DUF3422; pfam11902 114615019542 Uncharacterized conserved protein [Function unknown]; Region: COG3586 114615019543 Antitoxin Phd_YefM, type II toxin-antitoxin system; Region: PhdYeFM_antitox; pfam02604 114615019544 PIN domain of ribonucleases (toxins), VapC and FitB, of prokaryotic toxin/antitoxin operons, Pyrococcus horikoshii protein PH0500, and other similar bacterial and archaeal homologs; Region: PIN_VapC-FitB; cd09881 114615019545 oligomeric interface; other site 114615019546 putative active site [active] 114615019547 homodimer interface [polypeptide binding]; other site 114615019548 Glucose/sorbosone dehydrogenases [Carbohydrate transport and metabolism]; Region: COG2133 114615019549 NAD-dependent deacetylase; Provisional; Region: PRK05333 114615019550 SIRT4: Eukaryotic and prokaryotic group (class2) which includes human sirtuin SIRT4 and several bacterial homologs; and are members of the SIR2 family of proteins, silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein...; Region: SIRT4; cd01409 114615019551 NAD+ binding site [chemical binding]; other site 114615019552 substrate binding site [chemical binding]; other site 114615019553 Zn binding site [ion binding]; other site 114615019554 putative urate catabolism protein; Region: uraD_N-term-dom; TIGR03212 114615019555 Catalytic domain of bacterial PuuE allantoinases, Schizosaccharomyces pombe chitin deacetylase 1 (SpCDA1), and similar proteins; Region: CE4_PuuE_SpCDA1; cd10977 114615019556 active site 114615019557 catalytic site [active] 114615019558 tetramer interface [polypeptide binding]; other site 114615019559 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 114615019560 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 114615019561 dimer interface [polypeptide binding]; other site 114615019562 conserved gate region; other site 114615019563 putative PBP binding loops; other site 114615019564 ABC-ATPase subunit interface; other site 114615019565 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 114615019566 dimer interface [polypeptide binding]; other site 114615019567 conserved gate region; other site 114615019568 putative PBP binding loops; other site 114615019569 ABC-ATPase subunit interface; other site 114615019570 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 114615019571 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 114615019572 Walker A/P-loop; other site 114615019573 ATP binding site [chemical binding]; other site 114615019574 Q-loop/lid; other site 114615019575 ABC transporter signature motif; other site 114615019576 Walker B; other site 114615019577 D-loop; other site 114615019578 H-loop/switch region; other site 114615019579 TOBE domain; Region: TOBE_2; pfam08402 114615019580 Spermidine/putrescine-binding periplasmic protein [Amino acid transport and metabolism]; Region: PotD; COG0687 114615019581 Bacterial extracellular solute-binding protein; Region: SBP_bac_6; pfam13343 114615019582 Transcriptional regulators [Transcription]; Region: GntR; COG1802 114615019583 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 114615019584 DNA-binding site [nucleotide binding]; DNA binding site 114615019585 FCD domain; Region: FCD; pfam07729 114615019586 Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114 114615019587 cyclase homology domain; Region: CHD; cd07302 114615019588 nucleotidyl binding site; other site 114615019589 metal binding site [ion binding]; metal-binding site 114615019590 dimer interface [polypeptide binding]; other site 114615019591 Predicted integral membrane protein (DUF2282); Region: DUF2282; cl02366 114615019592 hypothetical protein; Provisional; Region: PRK05409 114615019593 Uncharacterized protein conserved in bacteria (DUF2063); Region: DUF2063; pfam09836 114615019594 Predicted membrane protein [Function unknown]; Region: COG2259 114615019595 Methyltransferase domain; Region: Methyltransf_31; pfam13847 114615019596 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 114615019597 S-adenosylmethionine binding site [chemical binding]; other site 114615019598 DPM_DPG-synthase_like is a member of the Glycosyltransferase 2 superfamily; Region: DPM_DPG-synthase_like; cd04179 114615019599 Ligand binding site; other site 114615019600 Putative Catalytic site; other site 114615019601 DXD motif; other site 114615019602 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3012 114615019603 SEC-C motif; Region: SEC-C; pfam02810 114615019604 SEC-C motif; Region: SEC-C; pfam02810 114615019605 Protein of unknown function (DUF419); Region: DUF419; pfam04237 114615019606 Carboxymuconolactone decarboxylase family; Region: CMD; pfam02627 114615019607 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 114615019608 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 114615019609 Sigma-70, region 4; Region: Sigma70_r4_2; pfam08281 114615019610 DNA binding residues [nucleotide binding] 114615019611 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 114615019612 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 114615019613 DNA binding residues [nucleotide binding] 114615019614 dimerization interface [polypeptide binding]; other site 114615019615 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 114615019616 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 114615019617 active site 114615019618 formamidase; Provisional; Region: amiF; PRK13287 114615019619 aliphatic amidases (class 2 nitrilases); Region: aliphatic_amidase; cd07565 114615019620 multimer interface [polypeptide binding]; other site 114615019621 active site 114615019622 catalytic triad [active] 114615019623 dimer interface [polypeptide binding]; other site 114615019624 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 114615019625 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 114615019626 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3558 114615019627 SnoaL-like domain; Region: SnoaL_2; pfam12680 114615019628 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 114615019629 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 114615019630 dimer interface [polypeptide binding]; other site 114615019631 phosphorylation site [posttranslational modification] 114615019632 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 114615019633 ATP binding site [chemical binding]; other site 114615019634 Mg2+ binding site [ion binding]; other site 114615019635 G-X-G motif; other site 114615019636 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 114615019637 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 114615019638 active site 114615019639 phosphorylation site [posttranslational modification] 114615019640 intermolecular recognition site; other site 114615019641 dimerization interface [polypeptide binding]; other site 114615019642 Opacity protein and related surface antigens [Cell envelope biogenesis, outer membrane]; Region: COG3637 114615019643 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 114615019644 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 114615019645 ATPase components of various ABC-type transport systems, contain duplicated ATPase [General function prediction only]; Region: COG1123 114615019646 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 114615019647 Walker A/P-loop; other site 114615019648 ATP binding site [chemical binding]; other site 114615019649 Q-loop/lid; other site 114615019650 ABC transporter signature motif; other site 114615019651 Walker B; other site 114615019652 D-loop; other site 114615019653 H-loop/switch region; other site 114615019654 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 114615019655 Walker A/P-loop; other site 114615019656 ATP binding site [chemical binding]; other site 114615019657 Q-loop/lid; other site 114615019658 ABC transporter signature motif; other site 114615019659 Walker B; other site 114615019660 D-loop; other site 114615019661 H-loop/switch region; other site 114615019662 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 114615019663 ABC-2 family transporter protein; Region: ABC2_membrane_2; cl17866 114615019664 putative efflux pump membrane fusion protein; Provisional; Region: PRK03598 114615019665 HlyD family secretion protein; Region: HlyD_3; pfam13437 114615019666 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 114615019667 TPR motif; other site 114615019668 FOG: TPR repeat [General function prediction only]; Region: NrfG; COG0457 114615019669 binding surface 114615019670 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 114615019671 TPR motif; other site 114615019672 binding surface 114615019673 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 114615019674 binding surface 114615019675 TPR motif; other site 114615019676 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 114615019677 binding surface 114615019678 TPR motif; other site 114615019679 Tetratricopeptide repeat; Region: TPR_12; pfam13424 114615019680 undecaprenyl pyrophosphate synthase; Provisional; Region: PRK14839 114615019681 Putative undecaprenyl diphosphate synthase; Region: Prenyltransf; pfam01255 114615019682 catalytic residue [active] 114615019683 putative FPP diphosphate binding site; other site 114615019684 putative FPP binding hydrophobic cleft; other site 114615019685 dimer interface [polypeptide binding]; other site 114615019686 putative IPP diphosphate binding site; other site 114615019687 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 114615019688 putative DNA binding site [nucleotide binding]; other site 114615019689 dimerization interface [polypeptide binding]; other site 114615019690 putative Zn2+ binding site [ion binding]; other site 114615019691 Hypothetical protein (DUF2513); Region: DUF2513; pfam10711 114615019692 Protein of unknown function (DUF3551); Region: DUF3551; pfam12071 114615019693 Tripartite tricarboxylate transporter family receptor; Region: TctC; cl17792 114615019694 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_2; cd07253 114615019695 dimer interface [polypeptide binding]; other site 114615019696 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 114615019697 metal binding site [ion binding]; metal-binding site 114615019698 Uncharacterized protein conserved in bacteria (DUF2330); Region: DUF2330; pfam10092 114615019699 NQR2, RnfD, RnfE family; Region: NQR2_RnfD_RnfE; cl00779 114615019700 Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318 114615019701 Uncharacterized subfamily of fatty acid CoA ligase (FACL); Region: FACL_DitJ_like; cd05934 114615019702 acyl-activating enzyme (AAE) consensus motif; other site 114615019703 putative AMP binding site [chemical binding]; other site 114615019704 putative active site [active] 114615019705 putative CoA binding site [chemical binding]; other site 114615019706 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 114615019707 Cytochrome P450; Region: p450; cl12078 114615019708 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 114615019709 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cl17736 114615019710 active site 114615019711 phosphorylation site [posttranslational modification] 114615019712 dimerization interface [polypeptide binding]; other site 114615019713 c-di-GMP phosphodiesterase class II (HD-GYP domain) [Signal transduction mechanisms]; Region: COG2206 114615019714 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 114615019715 Zn2+ binding site [ion binding]; other site 114615019716 Mg2+ binding site [ion binding]; other site 114615019717 Aerobic-type carbon monoxide dehydrogenase, large subunit CoxL/CutL homologs [Energy production and conversion]; Region: CoxL; COG1529 114615019718 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 114615019719 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; smart01008 114615019720 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 114615019721 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 114615019722 Aerobic-type carbon monoxide dehydrogenase, small subunit CoxS/CutS homologs [Energy production and conversion]; Region: CoxS; COG2080 114615019723 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 114615019724 catalytic loop [active] 114615019725 iron binding site [ion binding]; other site 114615019726 [2Fe-2S] binding domain; Region: Fer2_2; pfam01799 114615019727 Dienelactone hydrolase and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG0412 114615019728 Polysaccharide biosynthesis/export protein; Region: Poly_export; pfam02563 114615019729 putative polysaccharide export protein, PEP-CTERM sytem-associated; Region: pepcterm_export; TIGR03027 114615019730 SLBB domain; Region: SLBB; pfam10531 114615019731 methionine sulfoxide reductase A; Provisional; Region: PRK00058 114615019732 30S ribosomal protein S20; Reviewed; Region: rpsT; PRK00239