-- dump date   	20140619_005920
-- class       	Genbank::misc_feature
-- table       	misc_feature_note
-- id	note
335659000001	DnaA N-terminal domain; Region: DnaA_N; pfam11638
335659000002	chromosomal replication initiator protein DnaA; Region: DnaA; TIGR00362
335659000003	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
335659000004	Walker A motif; other site
335659000005	ATP binding site [chemical binding]; other site
335659000006	Walker B motif; other site
335659000007	arginine finger; other site
335659000008	C-terminal domain of bacterial DnaA proteins. The DNA-binding C-terminal domain of DnaA contains a helix-turn-helix motif that specifically interacts with the DnaA box, a 9-mer motif that occurs repetitively in the replication origin oriC. Multiple...; Region: Bac_DnaA_C; cd06571
335659000009	DnaA box-binding interface [nucleotide binding]; other site
335659000010	DNA polymerase III subunit beta; Validated; Region: PRK05643
335659000011	Beta clamp domain.  The beta subunit (processivity factor) of DNA polymerase III holoenzyme, refered to as the beta clamp, forms a ring shaped dimer that encircles dsDNA (sliding clamp) in bacteria.  The beta-clamp is structurally similar to the trimeric...; Region: beta_clamp; cd00140
335659000012	putative DNA binding surface [nucleotide binding]; other site
335659000013	dimer interface [polypeptide binding]; other site
335659000014	beta-clamp/clamp loader binding surface; other site
335659000015	beta-clamp/translesion DNA polymerase binding surface; other site
335659000016	recombination protein F; Reviewed; Region: recF; PRK00064
335659000017	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
335659000018	Walker A/P-loop; other site
335659000019	ATP binding site [chemical binding]; other site
335659000020	Q-loop/lid; other site
335659000021	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
335659000022	ABC transporter signature motif; other site
335659000023	Walker B; other site
335659000024	D-loop; other site
335659000025	H-loop/switch region; other site
335659000026	DNA gyrase subunit B; Provisional; Region: gyrB; PRK14939
335659000027	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
335659000028	ATP binding site [chemical binding]; other site
335659000029	Mg2+ binding site [ion binding]; other site
335659000030	G-X-G motif; other site
335659000031	TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822
335659000032	anchoring element; other site
335659000033	dimer interface [polypeptide binding]; other site
335659000034	ATP binding site [chemical binding]; other site
335659000035	TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of the...; Region: TOPRIM_TopoIIA_GyrB; cd03366
335659000036	active site
335659000037	putative metal-binding site [ion binding]; other site
335659000038	DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986
335659000039	UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Region: murA; TIGR01072
335659000040	UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555
335659000041	hinge; other site
335659000042	active site
335659000043	multidrug efflux protein; Reviewed; Region: PRK01766
335659000044	Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Vibrio cholerae NorM; Region: MATE_NorM_like; cd13131
335659000045	cation binding site [ion binding]; other site
335659000046	Protein of unknown function (DUF2867); Region: DUF2867; pfam11066
335659000047	DSBA-like thioredoxin domain; Region: DSBA; pfam01323
335659000048	DsbA family, 2-hydroxychromene-2-carboxylate (HCCA) isomerase subfamily; HCCA isomerase is a glutathione (GSH) dependent enzyme involved in the naphthalene catabolic pathway. It converts HCCA, a hemiketal formed spontaneously after ring cleavage of 1; Region: DsbA_HCCA_Iso; cd03022
335659000049	putative catalytic residue [active]
335659000050	Fusaric acid resistance protein family; Region: FUSC; pfam04632
335659000051	MmgE/PrpD family; Region: MmgE_PrpD; cl00912
335659000052	Beta-lactamase; Region: Beta-lactamase; pfam00144
335659000053	Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680
335659000054	7TM diverse intracellular signalling; Region: 7TMR-DISM_7TM; pfam07695
335659000055	Helix-turn-helix domain; Region: HTH_18; pfam12833
335659000056	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
335659000057	Pirin-related protein [General function prediction only]; Region: COG1741
335659000058	Pirin; Region: Pirin; pfam02678
335659000059	Pirin C-terminal cupin domain; Region: Pirin_C; pfam05726
335659000060	non-metazoan 5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide (SAICAR) synthase; Region: SAICAR_synt_Sc; cd01414
335659000061	ATP binding site [chemical binding]; other site
335659000062	active site
335659000063	substrate binding site [chemical binding]; other site
335659000064	Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659
335659000065	Sulfate transporter family; Region: Sulfate_transp; pfam00916
335659000066	Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function; Region: STAS_SulP_like_sulfate_transporter; cd07042
335659000067	cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664
335659000068	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
335659000069	ligand binding site [chemical binding]; other site
335659000070	flexible hinge region; other site
335659000071	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: RbsB; COG1879
335659000072	Periplasmic sugar-binding domain of active transport systems that are members of the type I periplasmic binding protein (PBP1) superfamily; Region: PBP1_ABC_sugar_binding_like; cd01536
335659000073	ligand binding site [chemical binding]; other site
335659000074	CHASE3 domain; Region: CHASE3; cl05000
335659000075	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
335659000076	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
335659000077	dimer interface [polypeptide binding]; other site
335659000078	phosphorylation site [posttranslational modification]
335659000079	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
335659000080	ATP binding site [chemical binding]; other site
335659000081	Mg2+ binding site [ion binding]; other site
335659000082	G-X-G motif; other site
335659000083	succinic semialdehyde dehydrogenase; Region: PLN02278
335659000084	Mitochondrial succinate-semialdehyde dehydrogenase and ALDH family members 5A1 and 5F1-like; Region: ALDH_F5_SSADH_GabD; cd07103
335659000085	tetramerization interface [polypeptide binding]; other site
335659000086	NAD(P) binding site [chemical binding]; other site
335659000087	catalytic residues [active]
335659000088	Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680
335659000089	Beta-lactamase; Region: Beta-lactamase; pfam00144
335659000090	Adenosine kinase (AK) catalyzes the phosphorylation of ribofuranosyl-containing nucleoside analogues at the 5'-hydroxyl using ATP or GTP as the phosphate donor.The physiological function of AK is associated with the regulation of extracellular...; Region: adenosine_kinase; cd01168
335659000091	Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524
335659000092	substrate binding site [chemical binding]; other site
335659000093	ATP binding site [chemical binding]; other site
335659000094	Uncharacterized membrane protein, putative virulence factor [General function prediction only]; Region: MviN; COG0728
335659000095	MurJ/MviN, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_MurJ_like; cd13123
335659000096	tryptophanyl-tRNA synthetase II; Reviewed; Region: PRK12282
335659000097	catalytic core domain of tryptophanyl-tRNA synthetase; Region: TrpRS_core; cd00806
335659000098	active site
335659000099	HIGH motif; other site
335659000100	dimer interface [polypeptide binding]; other site
335659000101	KMSKS motif; other site
335659000102	Scaffold protein Nfu/NifU N terminal; Region: Nfu_N; pfam08712
335659000103	Thioredoxin-like proteins and domains [Posttranslational modification, protein turnover, chaperones]; Region: COG0694
335659000104	tRNA threonylcarbamoyl adenosine modification protein YeaZ; Region: T6A_YeaZ; TIGR03725
335659000105	Glycoprotease family; Region: Peptidase_M22; pfam00814
335659000106	ribosomal-protein-alanine acetyltransferase; Region: rimI; TIGR01575
335659000107	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
335659000108	Coenzyme A binding pocket [chemical binding]; other site
335659000109	Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153
335659000110	metal binding site 2 [ion binding]; metal-binding site
335659000111	putative DNA binding helix; other site
335659000112	metal binding site 1 [ion binding]; metal-binding site
335659000113	dimer interface [polypeptide binding]; other site
335659000114	structural Zn2+ binding site [ion binding]; other site
335659000115	Predicted phosphatase/phosphohexomutase [General function prediction only]; Region: COG0637
335659000116	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
335659000117	motif I; other site
335659000118	active site
335659000119	(dimethylallyl)adenosine tRNA methylthiotransferase; Provisional; Region: PRK14325
335659000120	Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919
335659000121	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
335659000122	FeS/SAM binding site; other site
335659000123	Phosphate starvation-inducible protein PhoH, predicted ATPase [Signal transduction mechanisms]; Region: PhoH; COG1702
335659000124	K homology RNA-binding domain, type I.  KH binds single-stranded RNA or DNA. It is found in a wide variety of proteins including ribosomal proteins, transcription factors and post-transcriptional modifiers of mRNA. There are two different KH domains that...; Region: KH-I; cl17245
335659000125	PhoH-like protein; Region: PhoH; pfam02562
335659000126	metal-binding heat shock protein; Provisional; Region: PRK00016
335659000127	Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253
335659000128	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590
335659000129	Transporter associated domain; Region: CorC_HlyC; smart01091
335659000130	apolipoprotein N-acyltransferase; Reviewed; Region: lnt; PRK00302
335659000131	Apolipoprotein N-acyl transferase (class 9 nitrilases); Region: ALP_N-acyl_transferase; cd07571
335659000132	putative active site [active]
335659000133	catalytic triad [active]
335659000134	putative dimer interface [polypeptide binding]; other site
335659000135	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
335659000136	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
335659000137	non-specific DNA binding site [nucleotide binding]; other site
335659000138	salt bridge; other site
335659000139	sequence-specific DNA binding site [nucleotide binding]; other site
335659000140	hypothetical protein; Provisional; Region: PRK07338
335659000141	M20 Peptidase Glutamate carboxypeptidase, a periplasmic enzyme; Region: M20_CPDG2; cd03885
335659000142	metal binding site [ion binding]; metal-binding site
335659000143	dimer interface [polypeptide binding]; other site
335659000144	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
335659000145	S-adenosylmethionine binding site [chemical binding]; other site
335659000146	Uncharacterized protein conserved in bacteria (DUF2336); Region: DUF2336; pfam10098
335659000147	Uncharacterized BCR, YhbC family COG0779; Region: DUF150; pfam02576
335659000148	Sm and related proteins; Region: Sm_like; cl00259
335659000149	Bacillus subtilis YxlS-like, C-terminal domain; Region: YlxS_C; cd01734
335659000150	putative oligomer interface [polypeptide binding]; other site
335659000151	putative RNA binding site [nucleotide binding]; other site
335659000152	transcription elongation factor NusA; Validated; Region: nusA; PRK09202
335659000153	NusA N-terminal domain; Region: NusA_N; pfam08529
335659000154	S1_NusA: N-utilizing substance A protein (NusA), S1-like RNA-binding domain. S1-like RNA-binding domains are found in a wide variety of RNA-associated proteins. NusA is a transcription elongation factor containing an N-terminal catalytic domain and three...; Region: S1_NusA; cd04455
335659000155	RNA binding site [nucleotide binding]; other site
335659000156	homodimer interface [polypeptide binding]; other site
335659000157	NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134
335659000158	G-X-X-G motif; other site
335659000159	NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134
335659000160	G-X-X-G motif; other site
335659000161	transcription termination factor NusA, C-terminal duplication; Region: nusA_Cterm_rpt; TIGR01954
335659000162	hypothetical protein; Provisional; Region: PRK09190
335659000163	Ylxr homologs; group of conserved hypothetical bacterial proteins of unknown function; structure revealed putative RNA binding cleft; proteins are encoded by an operon that includes other proteins involved in transcription and/or translation; Region: YlxR; cd00279
335659000164	putative RNA binding cleft [nucleotide binding]; other site
335659000165	Bacterial translation initiation factor IF-2 associated region; Region: IF2_assoc; pfam08364
335659000166	Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760
335659000167	Translation initiation factor 2 (IF-2; GTPase) [Translation, ribosomal structure and biogenesis]; Region: InfB; COG0532
335659000168	Initiation Factor 2 (IF2)/ eukaryotic Initiation Factor 5B (eIF5B) family; Region: IF2_eIF5B; cd01887
335659000169	G1 box; other site
335659000170	putative GEF interaction site [polypeptide binding]; other site
335659000171	GTP/Mg2+ binding site [chemical binding]; other site
335659000172	Switch I region; other site
335659000173	G2 box; other site
335659000174	G3 box; other site
335659000175	Switch II region; other site
335659000176	G4 box; other site
335659000177	G5 box; other site
335659000178	This family represents the domain II of bacterial Initiation Factor 2 (IF2) and its eukaryotic mitochondrial homologue mtIF2. IF2, the largest initiation factor is an essential GTP binding protein. In E. coli three natural forms of IF2 exist in the cell; Region: IF2_mtIF2_II; cd03702
335659000179	Translation-initiation factor 2; Region: IF-2; pfam11987
335659000180	mtIF2_IVc: this family represents the C2 subdomain of domain IV of mitochondrial translation initiation factor 2 (mtIF2) which adopts a beta-barrel fold displaying a high degree of structural similarity with domain II of the translation elongation factor...; Region: mtIF2_IVc; cd03692
335659000181	ribosome-binding factor A; Validated; Region: rbfA; PRK00521
335659000182	tRNA pseudouridine synthase B; Provisional; Region: truB; PRK05389
335659000183	Pseudouridine synthase, Escherichia coli TruB like; Region: PseudoU_synth_EcTruB; cd02573
335659000184	RNA binding site [nucleotide binding]; other site
335659000185	active site
335659000186	Ribosomal protein S15 (prokaryotic)_S13 (eukaryotic) binds the central domain of 16S rRNA and is required for assembly of the small ribosomal subunit and for intersubunit association, thus representing a key element in the assembly of the whole ribosome; Region: Ribosomal_S15p_S13e; cd00353
335659000187	16S/18S rRNA binding site [nucleotide binding]; other site
335659000188	S13e-L30e interaction site [polypeptide binding]; other site
335659000189	25S rRNA binding site [nucleotide binding]; other site
335659000190	polynucleotide phosphorylase/polyadenylase; Provisional; Region: PRK11824
335659000191	Polyribonucleotide nucleotidyltransferase, repeat 1; Region: RNase_PH_PNPase_1; cd11363
335659000192	RNase E interface [polypeptide binding]; other site
335659000193	trimer interface [polypeptide binding]; other site
335659000194	Polyribonucleotide nucleotidyltransferase, RNA binding domain; Region: PNPase; pfam03726
335659000195	Polyribonucleotide nucleotidyltransferase, repeat 2; Region: RNase_PH_PNPase_2; cd11364
335659000196	RNase E interface [polypeptide binding]; other site
335659000197	trimer interface [polypeptide binding]; other site
335659000198	active site
335659000199	Polynucleotide phosphorylase (PNPase) K homology RNA-binding domain (KH). PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA in prokaryotes and plant chloroplasts. The C-terminal region of PNPase contains domains homologous to...; Region: PNPase_KH; cd02393
335659000200	putative nucleic acid binding region [nucleotide binding]; other site
335659000201	G-X-X-G motif; other site
335659000202	S1_PNPase: Polynucleotide phosphorylase (PNPase), ), S1-like RNA-binding domain. PNPase  is a polyribonucleotide nucleotidyl transferase that degrades mRNA. It is a trimeric multidomain protein. The C-terminus contains the S1 domain which binds ssRNA; Region: S1_PNPase; cd04472
335659000203	RNA binding site [nucleotide binding]; other site
335659000204	domain interface; other site
335659000205	Superoxide dismutase [Inorganic ion transport and metabolism]; Region: SodA; COG0605
335659000206	Iron/manganese superoxide dismutases, alpha-hairpin domain; Region: Sod_Fe_N; pfam00081
335659000207	Iron/manganese superoxide dismutases, C-terminal domain; Region: Sod_Fe_C; pfam02777
335659000208	catalase/hydroperoxidase HPI(I); Provisional; Region: PRK15061
335659000209	N-terminal catalytic domain of catalase-peroxidases; Region: catalase_peroxidase_1; cd00649
335659000210	dimer interface [polypeptide binding]; other site
335659000211	active site
335659000212	heme binding site [chemical binding]; other site
335659000213	C-terminal non-catalytic domain of catalase-peroxidases; Region: catalase_peroxidase_2; cd08200
335659000214	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
335659000215	DNA-binding transcriptional regulator OxyR; Provisional; Region: PRK11151
335659000216	The C-terminal substrate-binding domain of the LysR-type transcriptional regulator OxyR, a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_OxyR; cd08411
335659000217	dimerization interface [polypeptide binding]; other site
335659000218	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
335659000219	Coenzyme A binding pocket [chemical binding]; other site
335659000220	Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625
335659000221	GST_N family, Saccharomyces cerevisiae GTT1-like subfamily; composed of predominantly uncharacterized proteins with similarity to the S. cerevisiae GST protein, GTT1, and the Schizosaccharomyces pombe GST-III. GSTs are cytosolic dimeric proteins involved...; Region: GST_N_GTT1_like; cd03046
335659000222	putative C-terminal domain interface [polypeptide binding]; other site
335659000223	putative GSH binding site (G-site) [chemical binding]; other site
335659000224	putative dimer interface [polypeptide binding]; other site
335659000225	C-terminal, alpha helical domain of an unknown subfamily 8 of Glutathione S-transferases; Region: GST_C_8; cd03207
335659000226	dimer interface [polypeptide binding]; other site
335659000227	N-terminal domain interface [polypeptide binding]; other site
335659000228	putative substrate binding pocket (H-site) [chemical binding]; other site
335659000229	Autotransporter beta-domain; Region: Autotransporter; pfam03797
335659000230	enoyl-(acyl carrier protein) reductase; Provisional; Region: PRK06505
335659000231	Enoyl acyl carrier protein (ACP) reductase (ENR), divergent SDR; Region: ENR_SDR; cd05372
335659000232	NAD binding site [chemical binding]; other site
335659000233	homotetramer interface [polypeptide binding]; other site
335659000234	homodimer interface [polypeptide binding]; other site
335659000235	substrate binding site [chemical binding]; other site
335659000236	active site
335659000237	3-oxoacyl-(acyl carrier protein) synthase I; Reviewed; Region: PRK07967
335659000238	Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834
335659000239	dimer interface [polypeptide binding]; other site
335659000240	active site
335659000241	FabA, beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase: Bacterial protein of the type II, fatty acid synthase system that binds ACP and catalyzes both dehydration and isomerization reactions, apparently in the same active site. The FabA...; Region: FabA; cd01287
335659000242	active site 1 [active]
335659000243	dimer interface [polypeptide binding]; other site
335659000244	active site 2 [active]
335659000245	Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153
335659000246	metal binding site 2 [ion binding]; metal-binding site
335659000247	putative DNA binding helix; other site
335659000248	metal binding site 1 [ion binding]; metal-binding site
335659000249	dimer interface [polypeptide binding]; other site
335659000250	structural Zn2+ binding site [ion binding]; other site
335659000251	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3807
335659000252	Bacterial SH3 domain; Region: SH3_4; pfam06347
335659000253	Bacterial SH3 domain; Region: SH3_4; pfam06347
335659000254	Lactate dehydrogenase and related dehydrogenases [Energy production and conversion / Coenzyme metabolism / General function prediction only]; Region: LdhA; COG1052
335659000255	D-glycerate dehydrogenase/hydroxypyruvate reductase (GDH); Region: GDH; cd05301
335659000256	dimerization interface [polypeptide binding]; other site
335659000257	ligand binding site [chemical binding]; other site
335659000258	NADP binding site [chemical binding]; other site
335659000259	catalytic site [active]
335659000260	Transcriptional regulator [Transcription]; Region: LysR; COG0583
335659000261	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
335659000262	The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_5; cd08474
335659000263	putative effector binding pocket; other site
335659000264	putative dimerization interface [polypeptide binding]; other site
335659000265	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
335659000266	Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248
335659000267	active site
335659000268	catalytic tetrad [active]
335659000269	molybdopterin biosynthesis protein MoeB; Provisional; Region: PRK05690
335659000270	ThiF_MoeB_HesA. Family of E1-like enzymes involved in molybdopterin and thiamine biosynthesis family. The common reaction mechanism catalyzed by MoeB and ThiF, like other E1 enzymes, begins with a nucleophilic attack of the C-terminal carboxylate of MoaD...; Region: ThiF_MoeB_HesA_family; cd00757
335659000271	ATP binding site [chemical binding]; other site
335659000272	substrate interface [chemical binding]; other site
335659000273	Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471
335659000274	Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365
335659000275	Gamma-glutamyltransferase [Amino acid transport and metabolism]; Region: Ggt; COG0405
335659000276	Gamma-glutamyltranspeptidase; Region: G_glu_transpept; pfam01019
335659000277	ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192
335659000278	ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042
335659000279	P-loop; other site
335659000280	Magnesium ion binding site [ion binding]; other site
335659000281	formamidopyrimidine/5-formyluracil/ 5-hydroxymethyluracil DNA glycosylase; Validated; Region: PRK01103
335659000282	N-terminal domain of Escherichia coli Fpg1/MutM and related bacterial DNA glycosylases; Region: EcFpg-like_N; cd08966
335659000283	DNA binding site [nucleotide binding]
335659000284	catalytic residue [active]
335659000285	H2TH interface [polypeptide binding]; other site
335659000286	putative catalytic residues [active]
335659000287	turnover-facilitating residue; other site
335659000288	intercalation triad [nucleotide binding]; other site
335659000289	8OG recognition residue [nucleotide binding]; other site
335659000290	putative reading head residues; other site
335659000291	Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831
335659000292	Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827
335659000293	Methylase involved in ubiquinone/menaquinone biosynthesis [Coenzyme metabolism]; Region: UbiE; COG2226
335659000294	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
335659000295	S-adenosylmethionine binding site [chemical binding]; other site
335659000296	2-polyprenylphenol 6-hydroxylase; Region: UbiB; TIGR01982
335659000297	ABC1 family; Region: ABC1; pfam03109
335659000298	Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cd05120
335659000299	active site
335659000300	ATP binding site [chemical binding]; other site
335659000301	bifunctional SbtC-like/phosphopantothenoylcysteine decarboxylase/phosphopantothenate synthase; Provisional; Region: PRK13982
335659000302	Flavoprotein; Region: Flavoprotein; pfam02441
335659000303	DNA / pantothenate metabolism flavoprotein; Region: DFP; pfam04127
335659000304	Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557
335659000305	trimer interface [polypeptide binding]; other site
335659000306	active site
335659000307	PAS fold; Region: PAS_7; pfam12860
335659000308	phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966
335659000309	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
335659000310	dimer interface [polypeptide binding]; other site
335659000311	phosphorylation site [posttranslational modification]
335659000312	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
335659000313	ATP binding site [chemical binding]; other site
335659000314	Mg2+ binding site [ion binding]; other site
335659000315	G-X-G motif; other site
335659000316	Predicted ATPase or kinase [General function prediction only]; Region: COG0802
335659000317	Predicted phosphotransferase related to Ser/Thr protein kinases [General function prediction only]; Region: COG3178
335659000318	Phosphotransferase enzyme family; Region: APH; pfam01636
335659000319	PilZ domain; Region: PilZ; pfam07238
335659000320	Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis/translation initiation factor 2B, gamma/epsilon subunits (eIF-2Bgamma/eIF-2Bepsilon) [Cell envelope biogenesis, outer membrane / Translation, ribosomal structure...; Region: GCD1; COG1208
335659000321	NTP_transferase_like_1 is a member of the nucleotidyl transferase family; Region: NTP_transferase_like_1; cd06422
335659000322	Substrate binding site; other site
335659000323	metal-binding site
335659000324	double-strand break repair protein AddB, alphaproteobacterial type; Region: addB_alphas; TIGR02786
335659000325	CRISPR/Cas system-associated protein Cas4; Region: Cas4_I-A_I-B_I-C_I-D_II-B; cl00641
335659000326	double-strand break repair helicase AddA, alphaproteobacterial type; Region: addA_alphas; TIGR02784
335659000327	Part of AAA domain; Region: AAA_19; pfam13245
335659000328	Family description; Region: UvrD_C_2; pfam13538
335659000329	PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705
335659000330	TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947
335659000331	catalytic residues [active]
335659000332	ATP-dependent DNA ligase; Reviewed; Region: ligC; PRK08224
335659000333	Adenylation domain of Mycobacterium tuberculosis LigC-like ATP-dependent DNA ligases; Region: Adenylation_DNA_ligase_LigC; cd07905
335659000334	active site
335659000335	DNA binding site [nucleotide binding]
335659000336	The Oligonucleotide/oligosaccharide binding (OB)-fold domain of ATP-dependent DNA ligase LigC is a DNA-binding module that is part of the catalytic core unit; Region: OBF_DNA_ligase_LigC; cd07970
335659000337	DNA binding site [nucleotide binding]
335659000338	Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149
335659000339	metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cd00838
335659000340	active site
335659000341	metal binding site [ion binding]; metal-binding site
335659000342	Folylpolyglutamate synthase [Coenzyme metabolism]; Region: FolC; COG0285
335659000343	acetyl-CoA carboxylase subunit beta; Validated; Region: PRK05654
335659000344	malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682
335659000345	tryptophan synthase alpha subunit; Provisional; Region: trpA; CHL00200
335659000346	Ttryptophan synthase (TRPS) alpha subunit (TSA). TPRS is a bifunctional tetrameric enzyme (2 alpha and 2 beta subunits) that catalyzes the last two steps of L-tryptophan biosynthesis. Alpha and beta subunit catalyze two distinct reactions which are both...; Region: Tryptophan_synthase_alpha; cd04724
335659000347	substrate binding site [chemical binding]; other site
335659000348	active site
335659000349	catalytic residues [active]
335659000350	heterodimer interface [polypeptide binding]; other site
335659000351	tryptophan synthase, beta subunit; Region: trpB; TIGR00263
335659000352	Tryptophan synthase-beta:  Trptophan synthase is a bifunctional enzyme that catalyses the last two steps in the biosynthesis of L-tryptophan via its alpha and beta reactions. In the alpha reaction, indole 3-glycerol phosphate is cleaved reversibly to...; Region: Trp-synth_B; cd06446
335659000353	pyridoxal 5'-phosphate binding site [chemical binding]; other site
335659000354	catalytic residue [active]
335659000355	Phosphoribosylanthranilate isomerase (PRAI) catalyzes the fourth step of the tryptophan biosynthesis, the conversion of N-(5'- phosphoribosyl)-anthranilate (PRA) to 1-(o-carboxyphenylamino)- 1-deoxyribulose 5-phosphate (CdRP). Most PRAIs are...; Region: PRAI; cd00405
335659000356	active site
335659000357	Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591
335659000358	IHF dimer interface [polypeptide binding]; other site
335659000359	IHF - DNA interface [nucleotide binding]; other site
335659000360	signal peptide peptidase SppA, 36K type; Region: SppA_dom; TIGR00706
335659000361	Signal peptide peptidase A (SppA), a serine protease, has catalytic Ser-Lys dyad; Region: S49_Sppa_N_C; cd07023
335659000362	tandem repeat interface [polypeptide binding]; other site
335659000363	oligomer interface [polypeptide binding]; other site
335659000364	active site residues [active]
335659000365	30S ribosomal protein S1; Reviewed; Region: rpsA; PRK06299
335659000366	S1_RPS1_repeat_ec1_hs1: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec1_hs1; cd05687
335659000367	RNA binding site [nucleotide binding]; other site
335659000368	S1_RPS1_repeat_ec2_hs2: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec2_hs2; cd04465
335659000369	RNA binding site [nucleotide binding]; other site
335659000370	S1_RPS1_repeat_ec3: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec3; cd05688
335659000371	RNA binding site [nucleotide binding]; other site
335659000372	S1_RPS1_repeat_ec4: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec4; cd05689
335659000373	RNA binding site [nucleotide binding]; other site
335659000374	S1_RPS1_repeat_ec5: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec5; cd05690
335659000375	RNA binding site [nucleotide binding]; other site
335659000376	S1_RPS1_repeat_ec6: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec6; cd05691
335659000377	RNA binding site [nucleotide binding]; other site
335659000378	cytidylate kinase; Provisional; Region: cmk; PRK00023
335659000379	Cytidine monophosphate kinase (CMPK) catalyzes the reversible phosphorylation of cytidine monophosphate (CMP) to produce cytidine diphosphate (CDP), using ATP as the preferred phosphoryl donor; Region: CMPK; cd02020
335659000380	CMP-binding site; other site
335659000381	The sites determining sugar specificity; other site
335659000382	3-phosphoshikimate 1-carboxyvinyltransferase; Provisional; Region: PRK02427
335659000383	EPSP synthase domain. 3-phosphoshikimate 1-carboxyvinyltransferase (5-enolpyruvylshikimate-3-phosphate synthase) (EC 2.5.1.19) catalyses the reaction between shikimate-3-phosphate (S3P) and phosphoenolpyruvate (PEP) to form...; Region: EPSP_synthase; cd01556
335659000384	hinge; other site
335659000385	active site
335659000386	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4530
335659000387	Protein of unknown function (FYDLN_acid); Region: FYDLN_acid; pfam09538
335659000388	Catalytic GIY-YIG domain of yeast structure-specific endonuclease subunit SLX1 and its homologs; Region: GIY-YIG_SLX1_like; cd10449
335659000389	GIY-YIG motif/motif A; other site
335659000390	putative active site [active]
335659000391	putative metal binding site [ion binding]; other site
335659000392	helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347
335659000393	MarR family; Region: MarR; pfam01047
335659000394	peroxiredoxin, Ohr subfamily; Region: organ_hyd_perox; TIGR03561
335659000395	Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804
335659000396	CoA-transferase family III; Region: CoA_transf_3; pfam02515
335659000397	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199
335659000398	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653
335659000399	ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209
335659000400	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
335659000401	ABC-ATPase subunit interface; other site
335659000402	ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395
335659000403	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
335659000404	dimer interface [polypeptide binding]; other site
335659000405	conserved gate region; other site
335659000406	putative PBP binding loops; other site
335659000407	ABC-ATPase subunit interface; other site
335659000408	glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650
335659000409	The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301
335659000410	Walker A/P-loop; other site
335659000411	ATP binding site [chemical binding]; other site
335659000412	Q-loop/lid; other site
335659000413	ABC transporter signature motif; other site
335659000414	Walker B; other site
335659000415	D-loop; other site
335659000416	H-loop/switch region; other site
335659000417	TOBE domain; Region: TOBE_2; pfam08402
335659000418	Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071
335659000419	Alpha-crystallin domain (ACD) found in Escherichia coli inclusion body-associated proteins IbpA and IbpB, and similar proteins.  IbpA and IbpB are 16 kDa small heat shock proteins (sHsps). sHsps are molecular chaperones that suppress protein aggregation...; Region: ACD_IbpA-B_like; cd06470
335659000420	putative dimer interface [polypeptide binding]; other site
335659000421	Protein of unknown function (DUF1150); Region: DUF1150; pfam06620
335659000422	PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211
335659000423	active site
335659000424	phosphorylation site [posttranslational modification]
335659000425	RaiA ("ribosome-associated inhibitor A", also known as Protein Y (PY), YfiA, and SpotY,  is a stress-response protein that binds the ribosomal subunit interface and arrests translation by interfering with aminoacyl-tRNA binding to the ribosomal...; Region: RaiA; cd00552
335659000426	30S subunit binding site; other site
335659000427	Sigma-54 factor, Activator interacting domain (AID); Region: Sigma54_AID; pfam00309
335659000428	RNA polymerase factor sigma-54; Reviewed; Region: PRK05932
335659000429	Sigma-54 factor, core binding domain; Region: Sigma54_CBD; pfam04963
335659000430	Sigma-54, DNA binding domain; Region: Sigma54_DBD; pfam04552
335659000431	ABC-type (unclassified) transport system, ATPase component [General function prediction only]; Region: YhbG; COG1137
335659000432	ATP-binding cassette component of YhbG transport system; Region: ABC_YhbG; cd03218
335659000433	Walker A/P-loop; other site
335659000434	ATP binding site [chemical binding]; other site
335659000435	Q-loop/lid; other site
335659000436	ABC transporter signature motif; other site
335659000437	Walker B; other site
335659000438	D-loop; other site
335659000439	H-loop/switch region; other site
335659000440	lipopolysaccharide transport periplasmic protein LptA; Region: outer_YhbN_LptA; TIGR03002
335659000441	OstA-like protein; Region: OstA; pfam03968
335659000442	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5375
335659000443	Ribonuclease D [Translation, ribosomal structure and biogenesis]; Region: Rnd; COG0349
335659000444	DEDDy 3'-5' exonuclease domain of Ribonuclease D and similar proteins; Region: RNaseD_exo; cd06142
335659000445	catalytic site [active]
335659000446	putative active site [active]
335659000447	putative substrate binding site [chemical binding]; other site
335659000448	hypothetical protein; Validated; Region: PRK08238
335659000449	phosphoribose diphosphate:decaprenyl-phosphate phosphoribosyltransferase; Provisional; Region: PRK12324
335659000450	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
335659000451	Major Facilitator Superfamily; Region: MFS_1; pfam07690
335659000452	putative substrate translocation pore; other site
335659000453	NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, subunit 9, 39 kDa, (NDUFA9) -like, atypical (a) SDRs; Region: NDUFA9_like_SDR_a; cd05271
335659000454	putative NAD(P) binding site [chemical binding]; other site
335659000455	Predicted nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG0702
335659000456	active site
335659000457	Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300
335659000458	classical (c) SDRs; Region: SDR_c; cd05233
335659000459	NAD(P) binding site [chemical binding]; other site
335659000460	active site
335659000461	FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277
335659000462	FAD binding domain; Region: FAD_binding_4; pfam01565
335659000463	D-arabinono-1,4-lactone oxidase; Region: ALO; pfam04030
335659000464	undecaprenyl pyrophosphate phosphatase; Reviewed; Region: PRK00281
335659000465	Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625
335659000466	Glutathione S-transferase (GST) family, N-terminal domain; a large, diverse group of cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of  glutathione (GSH) with a wide range of endogenous and xenobiotic...; Region: GST_N_family; cd00570
335659000467	C-terminal domain interface [polypeptide binding]; other site
335659000468	GSH binding site (G-site) [chemical binding]; other site
335659000469	dimer interface [polypeptide binding]; other site
335659000470	C-terminal, alpha helical domain of the Glutathione S-transferase family; Region: GST_C_family; cl02776
335659000471	N-terminal domain interface [polypeptide binding]; other site
335659000472	dimer interface [polypeptide binding]; other site
335659000473	substrate binding pocket (H-site) [chemical binding]; other site
335659000474	epoxyqueuosine reductase; Region: TIGR00276
335659000475	Domain of unknown function (DUF1730); Region: DUF1730; pfam08331
335659000476	Thioesterase-like superfamily; Region: 4HBT_3; pfam13622
335659000477	SnoaL-like domain; Region: SnoaL_3; pfam13474
335659000478	SnoaL-like domain; Region: SnoaL_2; pfam12680
335659000479	Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596
335659000480	translation initiation factor IF-3; Reviewed; Region: infC; PRK00028
335659000481	Translation initiation factor IF-3, N-terminal domain; Region: IF3_N; pfam05198
335659000482	Translation initiation factor IF-3, C-terminal domain; Region: IF3_C; pfam00707
335659000483	50S ribosomal protein L35; Reviewed; Region: rpmI; PRK00172
335659000484	Ribosomal protein L20; Region: Ribosomal_L20; cd07026
335659000485	23S rRNA binding site [nucleotide binding]; other site
335659000486	L21 binding site [polypeptide binding]; other site
335659000487	L13 binding site [polypeptide binding]; other site
335659000488	phenylalanyl-tRNA synthetase subunit alpha; Validated; Region: pheS; PRK00488
335659000489	Aminoacyl tRNA synthetase class II, N-terminal domain; Region: Phe_tRNA-synt_N; pfam02912
335659000490	Phenylalanyl-tRNA synthetase (PheRS) alpha chain catalytic core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs. This domain is primarily responsible...; Region: PheRS_alpha_core; cd00496
335659000491	dimer interface [polypeptide binding]; other site
335659000492	motif 1; other site
335659000493	active site
335659000494	motif 2; other site
335659000495	motif 3; other site
335659000496	phenylalanyl-tRNA synthetase subunit beta; Reviewed; Region: pheT; PRK00629
335659000497	tRNA-binding-domain-containing prokaryotic phenylalanly tRNA synthetase (PheRS) beta chain.  PheRS aminoacylate phenylalanine transfer RNAs (tRNAphe). PheRSs belong structurally to class II aminoacyl tRNA synthetases (aaRSs) but, as they aminoacylate...; Region: tRNA_bind_bactPheRS; cd02796
335659000498	putative tRNA-binding site [nucleotide binding]; other site
335659000499	B3/4 domain; Region: B3_4; pfam03483
335659000500	tRNA synthetase B5 domain; Region: B5; smart00874
335659000501	Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA.   PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268
335659000502	dimer interface [polypeptide binding]; other site
335659000503	motif 1; other site
335659000504	active site
335659000505	motif 3; other site
335659000506	Ferredoxin-fold anticodon binding domain; Region: FDX-ACB; smart00896
335659000507	Sulfite exporter TauE/SafE; Region: TauE; pfam01925
335659000508	Flavin containing amine oxidoreductase; Region: Amino_oxidase; pfam01593
335659000509	Orthopoxvirus protein of unknown function (DUF830); Region: DUF830; cl13998
335659000510	Transcriptional regulators CsoR (copper-sensitive operon repressor), RcnR, and FrmR, and related domains; this domain superfamily was previously known as DUF156; Region: CsoR-like_DUF156; cd10148
335659000511	putative homodimer interface [polypeptide binding]; other site
335659000512	putative homotetramer interface [polypeptide binding]; other site
335659000513	putative allosteric switch controlling residues; other site
335659000514	putative metal binding site [ion binding]; other site
335659000515	putative homodimer-homodimer interface [polypeptide binding]; other site
335659000516	YHS domain; Region: YHS; pfam04945
335659000517	copper-(or silver)-translocating P-type ATPase; Region: ATPase-IB1_Cu; TIGR01511
335659000518	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
335659000519	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
335659000520	motif II; other site
335659000521	nickel responsive regulator; Provisional; Region: PRK02967
335659000522	NikR C terminal nickel binding domain; Region: NikR_C; pfam08753
335659000523	CysZ-like protein; Reviewed; Region: PRK12768
335659000524	drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711
335659000525	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
335659000526	putative substrate translocation pore; other site
335659000527	efflux pump membrane protein (multidrug resistance protein A); Region: 8a0101; TIGR00998
335659000528	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
335659000529	HlyD family secretion protein; Region: HlyD_3; pfam13437
335659000530	Predicted EndoIII-related endonuclease [DNA replication, recombination, and repair]; Region: Nth; COG0177
335659000531	endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056
335659000532	minor groove reading motif; other site
335659000533	helix-hairpin-helix signature motif; other site
335659000534	substrate binding pocket [chemical binding]; other site
335659000535	active site
335659000536	iron-sulpphur binding domain in DNA-(apurinic or apyrimidinic site) lyase (subfamily of ENDO3); Region: FES; smart00525
335659000537	Integral membrane protein (DUF2244); Region: DUF2244; pfam10003
335659000538	AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207
335659000539	Methylated DNA-protein cysteine methyltransferase [DNA replication, recombination, and repair]; Region: Ada; COG0350
335659000540	The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445
335659000541	DNA binding site [nucleotide binding]
335659000542	active site
335659000543	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
335659000544	catalytic core [active]
335659000545	dihydrodipicolinate reductase; Provisional; Region: PRK00048
335659000546	Dihydrodipicolinate reductase, N-terminus; Region: DapB_N; pfam01113
335659000547	Dihydrodipicolinate reductase, C-terminus; Region: DapB_C; pfam05173
335659000548	Uncharacterized conserved protein [Function unknown]; Region: COG5470
335659000549	Orotidine 5'-phosphate decarboxylase (ODCase) is a dimeric enzyme that decarboxylates orotidine 5'-monophosphate (OMP) to form uridine 5'-phosphate (UMP), an essential step in the pyrimidine biosynthetic pathway. In mammals, UMP synthase...; Region: OMP_decarboxylase_like; cd04725
335659000550	active site
335659000551	dimer interface [polypeptide binding]; other site
335659000552	Predicted flavoprotein [General function prediction only]; Region: COG0431
335659000553	NADPH-dependent FMN reductase; Region: FMN_red; pfam03358
335659000554	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
335659000555	S-adenosylmethionine binding site [chemical binding]; other site
335659000556	chaperone protein DnaJ; Provisional; Region: PRK10767
335659000557	DnaJ domain or J-domain.  DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257
335659000558	HSP70 interaction site [polypeptide binding]; other site
335659000559	C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cl03262
335659000560	substrate binding site [polypeptide binding]; other site
335659000561	Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719
335659000562	Zn binding sites [ion binding]; other site
335659000563	C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747
335659000564	dimer interface [polypeptide binding]; other site
335659000565	molecular chaperone DnaK; Provisional; Region: dnaK; PRK00290
335659000566	Nucleotide-binding domain of human HSPA9, Escherichia coli DnaK, and similar proteins; Region: HSPA9-like_NBD; cd11733
335659000567	nucleotide binding site [chemical binding]; other site
335659000568	NEF interaction site [polypeptide binding]; other site
335659000569	SBD interface [polypeptide binding]; other site
335659000570	heat shock protein GrpE; Provisional; Region: PRK14141
335659000571	GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70)-type ATPases. The GrpE dimer binds to the ATPase domain of Hsp70 catalyzing the dissociation of ADP, which enables rebinding of ATP, one step in the Hsp70 reaction cycle in protein folding; Region: GrpE; cd00446
335659000572	dimer interface [polypeptide binding]; other site
335659000573	hsp70 (ATPase domain) interactions [polypeptide binding]; other site
335659000574	heat-inducible transcription repressor; Provisional; Region: hrcA; PRK00082
335659000575	ribonuclease PH; Reviewed; Region: rph; PRK00173
335659000576	Ribonuclease PH; Region: RNase_PH_bact; cd11362
335659000577	hexamer interface [polypeptide binding]; other site
335659000578	active site
335659000579	NTPase/HAM1.  This family consists of the HAM1 protein and pyrophosphate-releasing xanthosine/ inosine triphosphatase. HAM1 protects the cell against mutagenesis by the base analog 6-N-hydroxylaminopurine (HAP) in E. Coli and S. cerevisiae. A...; Region: HAM1; cd00515
335659000580	active site
335659000581	dimerization interface [polypeptide binding]; other site
335659000582	coproporphyrinogen III oxidase; Provisional; Region: PRK09057
335659000583	HemN C-terminal domain; Region: HemN_C; pfam06969
335659000584	Protein of unknown function (DUF3800); Region: DUF3800; pfam12686
335659000585	Periplasmic binding protein; Region: Peripla_BP_6; pfam13458
335659000586	Periplasmic binding component of lipoprotein LppC, an immunodominant antigen; Region: PBP1_YraM_LppC_lipoprotein_like; cd06339
335659000587	putative ligand binding site [chemical binding]; other site
335659000588	Predicted methyltransferases [General function prediction only]; Region: COG0313
335659000589	Ribosomal RNA small subunit methyltransferase I, also known as rRNA (cytidine-2'-O-)-methyltransferase RsmI; Region: RsmI; cd11648
335659000590	putative SAM binding site [chemical binding]; other site
335659000591	putative homodimer interface [polypeptide binding]; other site
335659000592	hypothetical protein; Reviewed; Region: PRK12497
335659000593	glutathione synthetase; Provisional; Region: PRK05246
335659000594	Prokaryotic glutathione synthetase, N-terminal domain; Region: GSH-S_N; pfam02951
335659000595	Prokaryotic glutathione synthetase, ATP-grasp domain; Region: GSH-S_ATP; pfam02955
335659000596	Flp pilus assembly protein CpaB [Intracellular trafficking and secretion]; Region: CpaB; COG3745
335659000597	SAF domains of the flagella basal body P-ring formation protein FlgA and the flp pilus assembly CpaB; Region: SAF_CpaB_FlgA_like; cd11614
335659000598	Flp pilus assembly protein, secretin CpaC [Intracellular trafficking and secretion]; Region: CpaC; COG4964
335659000599	Pilus formation protein N terminal region; Region: T2SS-T3SS_pil_N; pfam13629
335659000600	BON domain; Region: BON; pfam04972
335659000601	Bacterial type II and III secretion system protein; Region: Secretin; pfam00263
335659000602	Type IV pili component [Cell motility and secretion]; Region: COG5461
335659000603	pilus (Caulobacter type) biogenesis lipoprotein CpaD; Region: pilus_cpaD; TIGR02522
335659000604	Antiactivator of flagellar biosynthesis FleN, an ATPase [Cell motility]; Region: flhG; COG0455
335659000605	This protein family consists of proteins similar to the cpaE protein of the Caulobacter pilus assembly and the orf4 protein of Actinobacillus pilus formation gene cluster. The function of these proteins are unkown. The Caulobacter pilus assembly contains...; Region: CpaE_like; cd03111
335659000606	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
335659000607	binding surface
335659000608	TPR motif; other site
335659000609	Tetratricopeptide repeat; Region: TPR_16; pfam13432
335659000610	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429
335659000611	binding surface
335659000612	TPR motif; other site
335659000613	Predicted ATPase with chaperone activity [Posttranslational modification, protein turnover, chaperones]; Region: COG0606
335659000614	Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541
335659000615	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
335659000616	Walker A motif; other site
335659000617	ATP binding site [chemical binding]; other site
335659000618	Walker B motif; other site
335659000619	arginine finger; other site
335659000620	Magnesium chelatase, subunit ChlI; Region: Mg_chelatase_2; pfam13335
335659000621	phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966
335659000622	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
335659000623	putative active site [active]
335659000624	heme pocket [chemical binding]; other site
335659000625	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
335659000626	dimer interface [polypeptide binding]; other site
335659000627	phosphorylation site [posttranslational modification]
335659000628	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
335659000629	ATP binding site [chemical binding]; other site
335659000630	Mg2+ binding site [ion binding]; other site
335659000631	G-X-G motif; other site
335659000632	Response regulator receiver domain; Region: Response_reg; pfam00072
335659000633	Response regulator receiver domain; Region: Response_reg; pfam00072
335659000634	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
335659000635	active site
335659000636	phosphorylation site [posttranslational modification]
335659000637	intermolecular recognition site; other site
335659000638	dimerization interface [polypeptide binding]; other site
335659000639	pantothenate kinase; Provisional; Region: PRK05439
335659000640	Pantothenate kinase (PanK) catalyzes the phosphorylation of pantothenic acid to form 4'-phosphopantothenic, which is the first of five steps in coenzyme A (CoA) biosynthetic pathway. The reaction carried out by this enzyme is a key regulatory point...; Region: PanK; cd02025
335659000641	ATP-binding site [chemical binding]; other site
335659000642	CoA-binding site [chemical binding]; other site
335659000643	Mg2+-binding site [ion binding]; other site
335659000644	Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in Escherichia coli phosphoribosyl-ATP pyrophosphohydrolase (HisIE or PRATP-PH) and its homologs; Region: NTP-PPase_HisIE_like; cd11534
335659000645	metal binding site [ion binding]; metal-binding site
335659000646	The cyclase subunit of imidazoleglycerol phosphate synthase (HisF). Imidazole glycerol phosphate synthase (IGPS) catalyzes the fifth step of histidine biosynthesis, the formation of the imidazole ring. IGPS converts N1-(5'-phosphoribulosyl)...; Region: HisF; cd04731
335659000647	Histidine biosynthesis protein; Region: His_biosynth; pfam00977
335659000648	substrate binding site [chemical binding]; other site
335659000649	glutamase interaction surface [polypeptide binding]; other site
335659000650	HisA.  Phosphoribosylformimino-5-aminoimidazole carboxamide ribonucleotide (ProFAR) isomerase catalyzes the fourth step in histidine biosynthesis, an isomerisation of the aminoaldose moiety of ProFAR to the aminoketose of PRFAR (N-(5'-phospho-D-1...; Region: HisA; cd04732
335659000651	phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase; Region: TIGR00007
335659000652	catalytic residues [active]
335659000653	imidazole glycerol phosphate synthase subunit HisH; Provisional; Region: hisH; PRK13146
335659000654	Type 1 glutamine amidotransferase (GATase1) domain found in imidazole glycerol phosphate synthase (IGPS); Region: GATase1_IGP_Synthase; cd01748
335659000655	putative active site [active]
335659000656	oxyanion strand; other site
335659000657	catalytic triad [active]
335659000658	Protein of unknown function (DUF2628); Region: DUF2628; pfam10947
335659000659	Imidazoleglycerol-phosphate dehydratase; Region: IGPD; cd07914
335659000660	putative active site pocket [active]
335659000661	4-fold oligomerization interface [polypeptide binding]; other site
335659000662	metal binding residues [ion binding]; metal-binding site
335659000663	3-fold/trimer interface [polypeptide binding]; other site
335659000664	Protease HslV and the ATPase/chaperone HslU are part of an ATP-dependent proteolytic system that is the prokaryotic homolog of the proteasome. HslV is a dimer of hexamers (a dodecamer) that forms a central proteolytic chamber with active sites on the...; Region: protease_HslV; cd01913
335659000665	active site
335659000666	HslU subunit interaction site [polypeptide binding]; other site
335659000667	hypothetical protein; Provisional; Region: PRK00944
335659000668	ATP-dependent protease ATP-binding subunit HslU; Provisional; Region: hslU; PRK05201
335659000669	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
335659000670	Walker A motif; other site
335659000671	ATP binding site [chemical binding]; other site
335659000672	AAA domain (Cdc48 subfamily); Region: AAA_2; pfam07724
335659000673	C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086
335659000674	Protein of unknown function (DUF3892); Region: DUF3892; pfam13031
335659000675	Smr domain; Region: Smr; pfam01713
335659000676	Membrane-bound lytic murein transglycosylase [Cell envelope biogenesis, outer membrane]; Region: MltA; COG2821
335659000677	MltA specific insert domain; Region: MltA; smart00925
335659000678	3D domain; Region: 3D; pfam06725
335659000679	Tim44-like domain; Region: Tim44; pfam04280
335659000680	preprotein translocase subunit SecB; Validated; Region: PRK05751
335659000681	SecA binding site; other site
335659000682	Preprotein binding site; other site
335659000683	DNA polymerase III, epsilon subunit, Proteobacterial; Region: dnaQ_proteo; TIGR01406
335659000684	DEDDh 3'-5' exonuclease domain of the epsilon subunit of Escherichia coli DNA polymerase III and similar proteins; Region: DNA_pol_III_epsilon_Ecoli_like; cd06131
335659000685	active site
335659000686	catalytic site [active]
335659000687	substrate binding site [chemical binding]; other site
335659000688	Dephospho-CoA kinase [Coenzyme metabolism]; Region: CoaE; COG0237
335659000689	Dephospho-coenzyme A kinase (DPCK, EC 2.7.1.24) catalyzes the phosphorylation of dephosphocoenzyme A (dCoA) to yield CoA, which is the final step in CoA biosynthesis; Region: DPCK; cd02022
335659000690	CoA-binding site [chemical binding]; other site
335659000691	ATP-binding [chemical binding]; other site
335659000692	Maf-like protein; Region: Maf; pfam02545
335659000693	Nucleotide binding protein Maf. Maf has been implicated in inhibition of septum formation in eukaryotes, bacteria and archaea, but homologs in B.subtilis and S.cerevisiae are nonessential for cell division. Maf has been predicted to be a nucleotide- or...; Region: Maf; cd00555
335659000694	active site
335659000695	dimer interface [polypeptide binding]; other site
335659000696	PEP synthetase regulatory protein; Provisional; Region: PRK05339
335659000697	Uncharacterized protein family (UPF0093); Region: UPF0093; pfam03653
335659000698	transcription termination factor Rho; Provisional; Region: rho; PRK09376
335659000699	Rho termination factor, N-terminal domain; Region: Rho_N; pfam07498
335659000700	Rho_CSD: Rho protein cold-shock domain (CSD). Rho protein is a transcription termination factor in most bacteria. In bacteria, there are two distinct mechanisms for mRNA transcription termination. In intrinsic termination, RNA polymerase and nascent mRNA...; Region: Rho_CSD; cd04459
335659000701	RNA binding site [nucleotide binding]; other site
335659000702	Transcription termination factor rho is a bacterial ATP-dependent RNA/DNA helicase. It is a homohexamer. Each monomer consists of an N-terminal domain of the OB fold, which is responsible for binding to cysteine rich nucleotides. This alignment is of the...; Region: rho_factor; cd01128
335659000703	multimer interface [polypeptide binding]; other site
335659000704	Walker A motif; other site
335659000705	ATP binding site [chemical binding]; other site
335659000706	Walker B motif; other site
335659000707	tRNA modification GTPase TrmE; Reviewed; Region: trmE; PRK05291
335659000708	GTP-binding protein TrmE N-terminus; Region: TrmE_N; pfam10396
335659000709	trmE is a tRNA modification GTPase; Region: trmE; cd04164
335659000710	G1 box; other site
335659000711	GTP/Mg2+ binding site [chemical binding]; other site
335659000712	Switch I region; other site
335659000713	G2 box; other site
335659000714	Switch II region; other site
335659000715	G3 box; other site
335659000716	G4 box; other site
335659000717	G5 box; other site
335659000718	tRNA uridine 5-carboxymethylaminomethyl modification enzyme GidA; Validated; Region: PRK05192
335659000719	tRNA (uracil-5-)-methyltransferase Gid; Reviewed; Region: PRK05335
335659000720	GidA associated domain 3; Region: GIDA_assoc_3; pfam13932
335659000721	Predicted S-adenosylmethionine-dependent methyltransferase involved in bacterial cell division [Cell envelope biogenesis, outer membrane]; Region: GidB; COG0357
335659000722	16S rRNA methyltransferase GidB; Reviewed; Region: gidB; PRK00107
335659000723	ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192
335659000724	ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042
335659000725	P-loop; other site
335659000726	Magnesium ion binding site [ion binding]; other site
335659000727	ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042
335659000728	Magnesium ion binding site [ion binding]; other site
335659000729	nucleoid occlusion protein; Region: nucleoid_noc; TIGR04285
335659000730	ParB-like nuclease domain; Region: ParB; smart00470
335659000731	DNA polymerase III subunit delta; Reviewed; Region: holA; PRK06585
335659000732	DNA polymerase III, delta subunit; Region: DNA_pol3_delta; pfam06144
335659000733	Lipopolysaccharide-assembly; Region: LptE; pfam04390
335659000734	leucyl-tRNA synthetase; Validated; Region: leuS; PRK00390
335659000735	catalytic core domain of leucyl-tRNA synthetases; Region: LeuRS_core; cd00812
335659000736	HIGH motif; other site
335659000737	Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603
335659000738	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
335659000739	active site
335659000740	KMSKS motif; other site
335659000741	Anticodon-binding domain of bacterial and eukaryotic mitochondrial leucyl tRNA synthetases; Region: Anticodon_Ia_Leu_BEm; cd07958
335659000742	tRNA binding surface [nucleotide binding]; other site
335659000743	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
335659000744	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
335659000745	metal binding site [ion binding]; metal-binding site
335659000746	active site
335659000747	I-site; other site
335659000748	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
335659000749	dimerization interface [polypeptide binding]; other site
335659000750	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
335659000751	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
335659000752	metal binding site [ion binding]; metal-binding site
335659000753	active site
335659000754	I-site; other site
335659000755	Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes, YBL036c-like proteins; Region: PLPDE_III_YBL036c_like; cd00635
335659000756	pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site
335659000757	catalytic residue [active]
335659000758	Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; cl11421
335659000759	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3786
335659000760	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
335659000761	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
335659000762	active site
335659000763	phosphorylation site [posttranslational modification]
335659000764	intermolecular recognition site; other site
335659000765	dimerization interface [polypeptide binding]; other site
335659000766	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
335659000767	DNA binding site [nucleotide binding]
335659000768	cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664
335659000769	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
335659000770	ligand binding site [chemical binding]; other site
335659000771	flexible hinge region; other site
335659000772	Escherichia coli exonuclease III (ExoIII) and Neisseria meningitides NExo-like subfamily of the ExoIII family purinic/apyrimidinic (AP) endonucleases; Region: ExoIII-like_AP-endo; cd09086
335659000773	putative catalytic site [active]
335659000774	putative phosphate binding site [ion binding]; other site
335659000775	active site
335659000776	metal binding site A [ion binding]; metal-binding site
335659000777	DNA binding site [nucleotide binding]
335659000778	putative AP binding site [nucleotide binding]; other site
335659000779	putative metal binding site B [ion binding]; other site
335659000780	Outer membrane lipoprotein-sorting protein [Cell envelope biogenesis, outer membrane]; Region: LolA; COG2834
335659000781	Outer membrane lipoprotein carrier protein LolA; Region: LolA; pfam03548
335659000782	Domain of unknown function (DUF4117); Region: DUF4117; pfam13491
335659000783	DNA segregation ATPase FtsK/SpoIIIE and related proteins [Cell division and chromosome partitioning]; Region: FtsK; COG1674
335659000784	FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580
335659000785	Ftsk gamma domain; Region: Ftsk_gamma; pfam09397
335659000786	succinyldiaminopimelate transaminase; Provisional; Region: PRK09147
335659000787	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
335659000788	pyridoxal 5'-phosphate binding site [chemical binding]; other site
335659000789	homodimer interface [polypeptide binding]; other site
335659000790	catalytic residue [active]
335659000791	Uncharacterized conserved protein [Function unknown]; Region: COG3791
335659000792	Ammonia permease [Inorganic ion transport and metabolism]; Region: AmtB; COG0004
335659000793	Nitrogen regulatory protein P-II; Region: P-II; pfam00543
335659000794	Nitrogen regulatory protein P-II; Region: P-II; smart00938
335659000795	Protease subunit of ATP-dependent Clp proteases [Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: ClpP; COG0740
335659000796	Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017
335659000797	oligomer interface [polypeptide binding]; other site
335659000798	active site residues [active]
335659000799	Putative hydrophobic ligand-binding SRPBCC domain of Micromonospora echinospora CalC, human Aha1, and related proteins; Region: SRPBCC_CalC_Aha1-like; cd07814
335659000800	putative hydrophobic ligand binding site [chemical binding]; other site
335659000801	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
335659000802	dimerization interface [polypeptide binding]; other site
335659000803	putative DNA binding site [nucleotide binding]; other site
335659000804	putative Zn2+ binding site [ion binding]; other site
335659000805	Ammonia permease [Inorganic ion transport and metabolism]; Region: AmtB; COG0004
335659000806	Nitrogen regulatory protein PII [Amino acid transport and metabolism]; Region: GlnK; COG0347
335659000807	Nitrogen regulatory protein P-II; Region: P-II; smart00938
335659000808	Domain of unknown function (DUF4339); Region: DUF4339; pfam14237
335659000809	Bacterial protein of unknown function (DUF898); Region: DUF898; cl01738
335659000810	Acyl-CoA thioesterase [Lipid metabolism]; Region: TesB; COG1946
335659000811	Thioesterase II (TEII) is thought to regenerate misprimed nonribosomal peptide synthetases (NRPSs) as well as modular polyketide synthases (PKSs) by hydrolyzing acetyl groups bound to the peptidyl carrier protein (PCP) and acyl carrier protein (ACP)...; Region: Thioesterase_II_repeat2; cd03445
335659000812	active site
335659000813	Thioesterase II (TEII) is thought to regenerate misprimed nonribosomal peptide synthetases (NRPSs) as well as modular polyketide synthases (PKSs) by hydrolyzing acetyl groups bound to the peptidyl carrier protein (PCP) and acyl carrier protein (ACP)...; Region: Thioesterase_II_repeat1; cd03444
335659000814	catalytic triad [active]
335659000815	dimer interface [polypeptide binding]; other site
335659000816	2-octaprenyl-6-methoxyphenyl hydroxylase; Provisional; Region: PRK07333
335659000817	ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314
335659000818	Uncharacterized conserved protein [Function unknown]; Region: COG2835
335659000819	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
335659000820	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
335659000821	Peptidase propeptide and YPEB domain; Region: PepSY_2; pfam13670
335659000822	Cytochrome b (N-terminus)/b6/petB:  Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria; Region: Cytochrome_b_N; cl00859
335659000823	Uncharacterized protein, similar to the N-terminal domain of Lon protease [General function prediction only]; Region: COG2802
335659000824	Thioredoxin domain-containing protein [Posttranslational modification, protein turnover, chaperones]; Region: COG3118
335659000825	TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947
335659000826	catalytic residues [active]
335659000827	Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451
335659000828	extended (e) SDRs; Region: SDR_e; cd08946
335659000829	NAD(P) binding site [chemical binding]; other site
335659000830	active site
335659000831	substrate binding site [chemical binding]; other site
335659000832	Glucose/sorbosone dehydrogenases [Carbohydrate transport and metabolism]; Region: COG2133
335659000833	Cytochrome c553 [Energy production and conversion]; Region: COG2863
335659000834	Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010
335659000835	Cytochrome c; Region: Cytochrom_C; cl11414
335659000836	2-dehydropantoate 2-reductase; Provisional; Region: PRK12921
335659000837	Ketopantoate reductase PanE/ApbA; Region: ApbA; pfam02558
335659000838	Ketopantoate reductase PanE/ApbA C terminal; Region: ApbA_C; pfam08546
335659000839	2-hydroxychromene-2-carboxylate isomerase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: NahD; COG3917
335659000840	DsbA family, 2-hydroxychromene-2-carboxylate (HCCA) isomerase subfamily; HCCA isomerase is a glutathione (GSH) dependent enzyme involved in the naphthalene catabolic pathway. It converts HCCA, a hemiketal formed spontaneously after ring cleavage of 1; Region: DsbA_HCCA_Iso; cd03022
335659000841	putative catalytic residue [active]
335659000842	Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Bacillus subtilis yoeA; Region: MATE_yoeA_like; cd13138
335659000843	Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534
335659000844	Uncharacterized protein conserved in bacteria (DUF2239); Region: DUF2239; pfam09998
335659000845	Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625
335659000846	GST_N family, Saccharomyces cerevisiae GTT1-like subfamily; composed of predominantly uncharacterized proteins with similarity to the S. cerevisiae GST protein, GTT1, and the Schizosaccharomyces pombe GST-III. GSTs are cytosolic dimeric proteins involved...; Region: GST_N_GTT1_like; cd03046
335659000847	putative C-terminal domain interface [polypeptide binding]; other site
335659000848	putative GSH binding site (G-site) [chemical binding]; other site
335659000849	putative dimer interface [polypeptide binding]; other site
335659000850	C-terminal, alpha helical domain of GTT1-like Glutathione S-transferases; Region: GST_C_GTT1_like; cd03189
335659000851	putative N-terminal domain interface [polypeptide binding]; other site
335659000852	putative dimer interface [polypeptide binding]; other site
335659000853	putative substrate binding pocket (H-site) [chemical binding]; other site
335659000854	benzoate transport; Region: 2A0115; TIGR00895
335659000855	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
335659000856	putative substrate translocation pore; other site
335659000857	Gamma-glutamyltransferase [Amino acid transport and metabolism]; Region: Ggt; COG0405
335659000858	Gamma-glutamyltranspeptidase; Region: G_glu_transpept; pfam01019
335659000859	Permeases of the major facilitator superfamily [General function prediction only]; Region: COG2270
335659000860	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
335659000861	bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; Provisional; Region: purH; PRK00881
335659000862	Inosine monophosphate cyclohydrolase domain. This is the N-terminal domain in the purine biosynthesis pathway protein ATIC (purH). The bifunctional ATIC protein contains a C-terminal  ATIC formylase domain that formylates...; Region: IMPCH; cd01421
335659000863	purine monophosphate binding site [chemical binding]; other site
335659000864	dimer interface [polypeptide binding]; other site
335659000865	putative catalytic residues [active]
335659000866	AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; smart00798
335659000867	AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; cl03362
335659000868	Heparinase II/III-like protein; Region: Hepar_II_III; cl15421
335659000869	RNA binding domain of NusB (N protein-Utilization Substance B) and Sun (also known as RrmB or Fmu) proteins. This family includes two orthologous groups exemplified by the transcription termination factor NusB and the N-terminal domain of the...; Region: NusB_Sun; cl00223
335659000870	tRNA and rRNA cytosine-C5-methylases [Translation, ribosomal structure and biogenesis]; Region: Sun; COG0144
335659000871	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
335659000872	S-adenosylmethionine binding site [chemical binding]; other site
335659000873	Uncharacterized conserved small protein [Function unknown]; Region: COG5508
335659000874	Protein of unknown function (DUF1674); Region: DUF1674; pfam07896
335659000875	Staphylococcal nuclease homologues. SNase homologues are found in bacteria, archaea, and eukaryotes. They contain no disufide bonds; Region: SNc; cl00140
335659000876	Catalytic site; other site
335659000877	Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376
335659000878	L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734
335659000879	acetyl-CoA synthetase; Provisional; Region: PRK00174
335659000880	Acetyl-CoA synthetase (also known as acetate-CoA ligase and acetyl-activating enzyme); Region: ACS; cd05966
335659000881	active site
335659000882	CoA binding site [chemical binding]; other site
335659000883	acyl-activating enzyme (AAE) consensus motif; other site
335659000884	AMP binding site [chemical binding]; other site
335659000885	acetate binding site [chemical binding]; other site
335659000886	Topoisomerase IB [DNA replication, recombination, and repair]; Region: COG3569
335659000887	Bacterial protein of unknown function (DUF905); Region: DUF905; pfam06006
335659000888	DNA topoisomerase IB, C-terminal catalytic domain. Topoisomerase I promotes the relaxation of both positive and negative DNA superhelical tension by introducing a transient single-stranded break in duplex DNA. This function is vital for the processes of...; Region: Topo_IB_C; cd00659
335659000889	active site
335659000890	DNA binding site [nucleotide binding]
335659000891	Int/Topo IB signature motif; other site
335659000892	catalytic residues [active]
335659000893	EVE domain; Region: EVE; pfam01878
335659000894	NAD(P)H-dependent glycerol-3-phosphate dehydrogenase; Validated; Region: gpsA; PRK00094
335659000895	NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210
335659000896	NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus; Region: NAD_Gly3P_dh_C; pfam07479
335659000897	UGMP family protein; Validated; Region: PRK09604
335659000898	Inactive homolog of metal-dependent proteases, putative molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: COG1214; cl17884
335659000899	Uroporphyrinogen-III synthase [Coenzyme metabolism]; Region: HemD; COG1587
335659000900	Uroporphyrinogen-III synthase (HemD) catalyzes the asymmetrical cyclization of tetrapyrrole (linear) to uroporphyrinogen-III, the fourth step in the biosynthesis of heme. This ubiquitous enzyme is present in eukaryotes, bacteria and archaea. Mutations in...; Region: HemD; cd06578
335659000901	active site
335659000902	Uncharacterized membrane-bound protein [Function unknown]; Region: COG3898
335659000903	HemY protein N-terminus; Region: HemY_N; pfam07219
335659000904	Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726
335659000905	Catalytic NodB homology domain of rhizobial NodB-like proteins; Region: CE4_NodB_like_6s_7s; cd10917
335659000906	NodB motif; other site
335659000907	active site
335659000908	catalytic site [active]
335659000909	metal binding site [ion binding]; metal-binding site
335659000910	Cysteine rich repeat; Region: Cys_rich_FGFR; pfam00839
335659000911	Transmembrane secretion effector; Region: MFS_3; pfam05977
335659000912	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
335659000913	putative substrate translocation pore; other site
335659000914	Predicted acetyltransferases and hydrolases with the alpha/beta hydrolase fold [General function prediction only]; Region: LipA; COG1075
335659000915	Cytochrome P450; Region: p450; cl12078
335659000916	Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124
335659000917	Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114
335659000918	cyclase homology domain; Region: CHD; cd07302
335659000919	nucleotidyl binding site; other site
335659000920	metal binding site [ion binding]; metal-binding site
335659000921	dimer interface [polypeptide binding]; other site
335659000922	tellurium resistance terB-like protein, subgroup 2; Region: terB_like_2; cd07313
335659000923	putative metal binding site [ion binding]; other site
335659000924	Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300
335659000925	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
335659000926	NAD(P) binding site [chemical binding]; other site
335659000927	active site
335659000928	Subgroup of proteins having the Type 1 glutamine amidotransferase (GATase1) domain; Region: GATase1_1; cd01741
335659000929	GMP synthase - Glutamine amidotransferase domain [Nucleotide transport and metabolism]; Region: GuaA; COG0518
335659000930	catalytic triad [active]
335659000931	enoyl-CoA hydratase; Provisional; Region: PRK06210
335659000932	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
335659000933	substrate binding site [chemical binding]; other site
335659000934	oxyanion hole (OAH) forming residues; other site
335659000935	trimer interface [polypeptide binding]; other site
335659000936	hypothetical protein; Validated; Region: PRK01310
335659000937	bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate cyclohydrolase; Provisional; Region: PRK14188
335659000938	Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain; Region: THF_DHG_CYH; pfam00763
335659000939	NADP binding domain of methylene-tetrahydrofolate dehydrogenase/cyclohydrolase; Region: NAD_bind_m-THF_DH_Cyclohyd; cd01080
335659000940	homodimer interface [polypeptide binding]; other site
335659000941	NADP binding site [chemical binding]; other site
335659000942	substrate binding site [chemical binding]; other site
335659000943	Inorganic pyrophosphatase. These enzymes hydrolyze inorganic pyrophosphate (PPi) to two molecules of orthophosphates (Pi). The reaction requires bivalent cations. The enzymes in general exist as homooligomers; Region: pyrophosphatase; cd00412
335659000944	dimer interface [polypeptide binding]; other site
335659000945	substrate binding site [chemical binding]; other site
335659000946	metal binding sites [ion binding]; metal-binding site
335659000947	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
335659000948	Coenzyme A binding pocket [chemical binding]; other site
335659000949	Dienelactone hydrolase and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG0412
335659000950	Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326
335659000951	Predicted thiol-disulfide oxidoreductase [General function    prediction only]; Region: COG3011
335659000952	Flavin containing amine oxidoreductase; Region: Amino_oxidase; pfam01593
335659000953	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
335659000954	Predicted membrane GTPase involved in stress response [Signal transduction mechanisms]; Region: TypA; COG1217
335659000955	Tyrosine phosphorylated protein A (TypA)/BipA family belongs to ribosome-binding GTPases; Region: TypA_BipA; cd01891
335659000956	G1 box; other site
335659000957	putative GEF interaction site [polypeptide binding]; other site
335659000958	GTP/Mg2+ binding site [chemical binding]; other site
335659000959	Switch I region; other site
335659000960	G2 box; other site
335659000961	G3 box; other site
335659000962	Switch II region; other site
335659000963	G4 box; other site
335659000964	G5 box; other site
335659000965	BipA_TypA_II: domain II of BipA (also called TypA) having homology to domain II of the elongation factors (EFs) EF-G and EF-Tu.  BipA is a highly conserved protein with global regulatory properties in Escherichia coli. BipA is phosphorylated on a...; Region: BipA_TypA_II; cd03691
335659000966	BipA_TypA_C: a C-terminal portion of BipA or TypA having homology to the C terminal domains of the elongation factors EF-G and EF-2. A member of the ribosome binding GTPase superfamily, BipA is widely distributed in bacteria and plants.  BipA is a highly...; Region: BipA_TypA_C; cd03710
335659000967	Predicted Fe-S oxidoreductases [General function prediction only]; Region: COG1964
335659000968	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
335659000969	FeS/SAM binding site; other site
335659000970	Prolipoprotein diacylglyceryl transferase; Region: LGT; cl00478
335659000971	cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664
335659000972	Crp-like helix-turn-helix domain; Region: HTH_Crp_2; pfam13545
335659000973	putative switch regulator; other site
335659000974	non-specific DNA interactions [nucleotide binding]; other site
335659000975	DNA binding site [nucleotide binding]
335659000976	sequence specific DNA binding site [nucleotide binding]; other site
335659000977	putative cAMP binding site [chemical binding]; other site
335659000978	Response regulator receiver domain; Region: Response_reg; pfam00072
335659000979	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
335659000980	active site
335659000981	phosphorylation site [posttranslational modification]
335659000982	intermolecular recognition site; other site
335659000983	dimerization interface [polypeptide binding]; other site
335659000984	Phosphodiesterase/alkaline phosphatase D [Inorganic ion transport and metabolism]; Region: PhoD; COG3540
335659000985	Bacillus subtilis PhoD and related proteins, metallophosphatase domain; Region: MPP_PhoD; cd07389
335659000986	putative active site [active]
335659000987	TRAP transporter solute receptor, TAXI family; Region: TRAP_TAXI; TIGR02122
335659000988	PCD_DCoH: The bifunctional protein pterin-4alpha-carbinolamine dehydratase (PCD), also known as DCoH  (dimerization cofactor of hepatocyte nuclear factor-1), is both a transcription activator and a metabolic enzyme.  DCoH stimulates gene expression by...; Region: PCD_DCoH_subfamily_b; cd00914
335659000989	aromatic arch; other site
335659000990	DCoH dimer interaction site [polypeptide binding]; other site
335659000991	DCoH /HNF-1 dimer interaction site [polypeptide binding]; other site
335659000992	DCoH tetramer interaction site [polypeptide binding]; other site
335659000993	substrate binding site [chemical binding]; other site
335659000994	Uncharacterized conserved protein [Function unknown]; Region: COG3339
335659000995	TRAP transporter solute receptor, TAXI family; Region: TRAP_TAXI; TIGR02122
335659000996	NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604
335659000997	Quinone oxidoreductase (QOR); Region: QOR1; cd08241
335659000998	NAD(P) binding site [chemical binding]; other site
335659000999	Trans-2-enoyl-CoA reductase (TER) and 2,4-dienoyl-CoA reductase (DECR), atypical (a) SDR; Region: TER_DECR_SDR_a; cd05369
335659001000	short chain dehydrogenase; Provisional; Region: PRK07677
335659001001	NAD(P) binding site [chemical binding]; other site
335659001002	substrate binding site [chemical binding]; other site
335659001003	homotetramer interface [polypeptide binding]; other site
335659001004	active site
335659001005	homodimer interface [polypeptide binding]; other site
335659001006	Predicted Fe-S-cluster redox enzyme [General function prediction only]; Region: COG0820
335659001007	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
335659001008	FeS/SAM binding site; other site
335659001009	PAP2_like_6 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which mainly contains bacterial proteins, lacks functional characterization and may act as a membrane-associated lipid phosphatase; Region: PAP2_like_6; cd03396
335659001010	active site
335659001011	argininosuccinate synthase; Provisional; Region: PRK13820
335659001012	Argininosuccinate synthase. The Argininosuccinate synthase is a urea cycle enzyme that catalyzes the penultimate step in arginine biosynthesis: the ATP-dependent ligation of citrulline to aspartate to form argininosuccinate, AMP and pyrophosphate .  In...; Region: Argininosuccinate_Synthase; cd01999
335659001013	ANP binding site [chemical binding]; other site
335659001014	Substrate Binding Site II [chemical binding]; other site
335659001015	Substrate Binding Site I [chemical binding]; other site
335659001016	Alkaline phosphatase homologues; alkaline phosphatases are non-specific phosphomonoesterases that catalyze the hydrolysis reaction via a phosphoseryl intermediate to produce inorganic phosphate and the corresponding alcohol, optimally at high pH; Region: alkPPc; cd00016
335659001017	Alkaline phosphatase homologues; Region: alkPPc; smart00098
335659001018	active site
335659001019	dimer interface [polypeptide binding]; other site
335659001020	Alkaline phosphatase homologues; alkaline phosphatases are non-specific phosphomonoesterases that catalyze the hydrolysis reaction via a phosphoseryl intermediate to produce inorganic phosphate and the corresponding alcohol, optimally at high pH; Region: alkPPc; cl15837
335659001021	Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885
335659001022	Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185
335659001023	ligand binding site [chemical binding]; other site
335659001024	Uncharacterized stress protein (general stress protein 26) [General function prediction only]; Region: COG3871
335659001025	Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_oxidase; pfam01243
335659001026	This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_19; cd07262
335659001027	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
335659001028	methyltransferase, FkbM family; Region: fkbM_fam; TIGR01444
335659001029	ABC-type uncharacterized transport system, permease and ATPase components [General function prediction only]; Region: COG4178
335659001030	ABC transporter transmembrane region 2; Region: ABC_membrane_2; cl00549
335659001031	ATP-binding cassette domain of peroxisomal transporter, subfamily D; Region: ABCD_peroxisomal_ALDP; cd03223
335659001032	choline dehydrogenase; Validated; Region: PRK02106
335659001033	GMC oxidoreductase; Region: GMC_oxred_C; pfam05199
335659001034	Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789
335659001035	Helix-Turn-Helix DNA binding domain of truncated MerR-like proteins; Region: HTH_MerR-trunc; cd04762
335659001036	DNA binding residues [nucleotide binding]
335659001037	GAF domain; Region: GAF; pfam01590
335659001038	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
335659001039	succinate dehydrogenase iron-sulfur subunit; Reviewed; Region: sdhB; PRK05950
335659001040	2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_3; pfam13085
335659001041	succinate dehydrogenase flavoprotein subunit; Reviewed; Region: sdhA; PRK09078
335659001042	L-aspartate oxidase; Provisional; Region: PRK06175
335659001043	Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910
335659001044	Succinate:quinone oxidoreductase (SQR) Type C subfamily, Succinate dehydrogenase D (SdhD) subunit-like; composed of predominantly uncharacterized bacterial proteins with similarity to the E. coli SdhD subunit. One characterized protein is the respiratory...; Region: SQR_TypeC_SdhD_like; cd03495
335659001045	putative SdhC subunit interface [polypeptide binding]; other site
335659001046	putative proximal heme binding site [chemical binding]; other site
335659001047	putative Iron-sulfur protein interface [polypeptide binding]; other site
335659001048	putative proximal quinone binding site; other site
335659001049	Succinate:quinone oxidoreductase (SQR) Type C subfamily, Succinate dehydrogenase C (SdhC) subunit; composed of bacterial SdhC and eukaryotic large cytochrome b binding (CybL) proteins. SQR catalyzes the oxidation of succinate to fumarate coupled to the...; Region: SQR_TypeC_SdhC; cd03499
335659001050	Iron-sulfur protein interface; other site
335659001051	proximal quinone binding site [chemical binding]; other site
335659001052	SdhD (CybS) interface [polypeptide binding]; other site
335659001053	proximal heme binding site [chemical binding]; other site
335659001054	Sulfite exporter TauE/SafE; Region: TauE; pfam01925
335659001055	malonyl-CoA synthase; Validated; Region: PRK07514
335659001056	Malonyl-CoA synthetase (MCS); Region: MCS; cd05941
335659001057	acyl-activating enzyme (AAE) consensus motif; other site
335659001058	active site
335659001059	AMP binding site [chemical binding]; other site
335659001060	CoA binding site [chemical binding]; other site
335659001061	Short-chain alcohol dehydrogenase of unknown specificity [General function prediction only]; Region: COG4221
335659001062	classical (c) SDRs; Region: SDR_c; cd05233
335659001063	NAD(P) binding site [chemical binding]; other site
335659001064	active site
335659001065	Secreted and surface protein containing fasciclin-like repeats [Cell envelope biogenesis, outer membrane]; Region: COG2335
335659001066	Fasciclin domain; Region: Fasciclin; pfam02469
335659001067	Cytochrome b(N-terminal)/b6/petB; Region: Cytochrom_B_N; pfam00033
335659001068	Sulfite oxidase and related enzymes [General function prediction only]; Region: COG2041
335659001069	bacterial subgroup of the sulfite oxidase (SO) family of molybdopterin binding domains. This domain is found in a variety of oxidoreductases. Common features of all known members of this family, like sulfite oxidase and nitrite reductase, are that they...; Region: bact_SO_family_Moco; cd02108
335659001070	Moco binding site; other site
335659001071	metal coordination site [ion binding]; other site
335659001072	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
335659001073	putative substrate translocation pore; other site
335659001074	tartrate dehydrogenase; Region: TTC; TIGR02089
335659001075	3-isopropylmalate dehydrogenase; Provisional; Region: PRK00772
335659001076	phosphonate metabolim protein, transferase hexapeptide repeat family; Region: phn_thr-fam; TIGR03308
335659001077	Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160
335659001078	putative trimer interface [polypeptide binding]; other site
335659001079	Xenobiotic acyltransferase (XAT): The XAT class of hexapeptide acyltransferases is composed of a large number of microbial enzymes that catalyze the CoA-dependent acetylation of a variety of hydroxyl-bearing acceptors such as chloramphenicol and...; Region: LbH_XAT; cd03349
335659001080	trimer interface [polypeptide binding]; other site
335659001081	active site
335659001082	substrate binding site [chemical binding]; other site
335659001083	putative CoA binding site [chemical binding]; other site
335659001084	CoA binding site [chemical binding]; other site
335659001085	aspartate-semialdehyde dehydrogenase; Provisional; Region: PRK14874
335659001086	Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859
335659001087	Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA_cladeB; cd00884
335659001088	active site clefts [active]
335659001089	zinc binding site [ion binding]; other site
335659001090	dimer interface [polypeptide binding]; other site
335659001091	Citrate lyase beta subunit [Carbohydrate transport and metabolism]; Region: CitE; COG2301
335659001092	Predicted phosphatases [General function prediction only]; Region: Gph; COG0546
335659001093	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
335659001094	motif II; other site
335659001095	Caspase domain; Region: Peptidase_C14; pfam00656
335659001096	active site
335659001097	DNA Topoisomerase IV; Region: TOP4c; smart00434
335659001098	isopropylmalate isomerase small subunit; Provisional; Region: leuD; PRK01641
335659001099	Aconatase-like swivel domain of 3-isopropylmalate dehydratase and related uncharacterized proteins. 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate...; Region: IPMI_Swivel; cd01577
335659001100	substrate binding site [chemical binding]; other site
335659001101	Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_oxidase; pfam01243
335659001102	Helix-turn-helix domain; Region: HTH_31; pfam13560
335659001103	Minimal MMP-like domain found in Acidothermus cellulolyticus hypothetical protein ACEL2062 and similar protein; Region: MMP_ACEL2062; cd12952
335659001104	3-isopropylmalate dehydratase large subunit; Reviewed; Region: PRK00402
335659001105	3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate; Region: IPMI; cd01583
335659001106	substrate binding site [chemical binding]; other site
335659001107	ligand binding site [chemical binding]; other site
335659001108	50S ribosomal protein L19; Provisional; Region: rplS; PRK05338
335659001109	tRNA (guanine-N(1)-)-methyltransferase; Reviewed; Region: trmD; PRK00026
335659001110	RimM N-terminal domain; Region: RimM; pfam01782
335659001111	16S rRNA-processing protein RimM; Provisional; Region: rimM; PRK13828
335659001112	PRC-barrel domain; Region: PRC; pfam05239
335659001113	30S ribosomal protein S16; Reviewed; Region: rpsP; PRK00040
335659001114	signal recognition particle protein; Provisional; Region: PRK10867
335659001115	SRP54-type protein, helical bundle domain; Region: SRP54_N; smart00963
335659001116	The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115
335659001117	P loop; other site
335659001118	GTP binding site [chemical binding]; other site
335659001119	Signal peptide binding domain; Region: SRP_SPB; pfam02978
335659001120	Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220
335659001121	Beta-lactamase superfamily domain; Region: Lactamase_B_2; pfam12706
335659001122	Uncharacterized conserved protein [Function unknown]; Region: COG2968
335659001123	Protein of unknown function (DUF541); Region: SIMPL; pfam04402
335659001124	Bacterial transcription activator, effector binding domain; Region: AraC_E_bind; smart00871
335659001125	diaminopimelate epimerase; Provisional; Region: dapF; PRK00450
335659001126	Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678
335659001127	Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678
335659001128	2-methylthioadenine synthetase [Translation, ribosomal structure and biogenesis]; Region: MiaB; COG0621
335659001129	Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919
335659001130	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
335659001131	FeS/SAM binding site; other site
335659001132	Uncharacterized protein conserved in bacteria (DUF2336); Region: DUF2336; pfam10098
335659001133	Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564
335659001134	Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869
335659001135	active site
335659001136	signal recognition particle-docking protein FtsY; Provisional; Region: PRK10416
335659001137	SRP54-type protein, helical bundle domain; Region: SRP54_N; pfam02881
335659001138	The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115
335659001139	P loop; other site
335659001140	GTP binding site [chemical binding]; other site
335659001141	intracellular septation protein A; Reviewed; Region: PRK00259
335659001142	TlpA-like family, DsbE (also known as CcmG and CycY) subfamily; DsbE is a membrane-anchored, periplasmic TRX-like reductase containing a CXXC motif that specifically donates reducing equivalents to apocytochrome c via CcmH, another cytochrome c...; Region: TlpA_like_DsbE; cd03010
335659001143	Thioredoxin-like; Region: Thioredoxin_8; pfam13905
335659001144	catalytic residues [active]
335659001145	central insert; other site
335659001146	heme exporter protein CcmC; Region: ccmC; TIGR01191
335659001147	heme exporter protein CcmB; Region: ccmB; TIGR01190
335659001148	cytochrome c biogenesis protein CcmA; Provisional; Region: PRK13539
335659001149	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
335659001150	Walker A/P-loop; other site
335659001151	ATP binding site [chemical binding]; other site
335659001152	Q-loop/lid; other site
335659001153	ABC transporter signature motif; other site
335659001154	Walker B; other site
335659001155	D-loop; other site
335659001156	H-loop/switch region; other site
335659001157	aconitate hydratase; Validated; Region: PRK09277
335659001158	Aconitase A catalytic domain; Region: AcnA_IRP; cd01586
335659001159	substrate binding site [chemical binding]; other site
335659001160	ligand binding site [chemical binding]; other site
335659001161	Aconitase A swivel domain. This is the major form of the TCA cycle enzyme aconitate hydratase, also known as aconitase and citrate hydro-lyase. It includes bacterial and archaeal aconitase A, and the eukaryotic cytosolic form of aconitase. This group...; Region: AcnA_IRP_Swivel; cd01580
335659001162	substrate binding site [chemical binding]; other site
335659001163	Protein of unknown function (DUF1223); Region: DUF1223; pfam06764
335659001164	Protein of unknown function (DUF2794); Region: DUF2794; pfam10984
335659001165	Sortase and related acyltransferases [Cell envelope biogenesis, outer membrane]; Region: COG1247
335659001166	Integral membrane protein, interacts with FtsH [General function prediction only]; Region: COG0670
335659001167	Bacterial BAX inhibitor (BI)-1/YccA-like proteins; Region: BI-1-like_bacterial; cd10432
335659001168	Predicted ABC-type transport system involved in lysophospholipase L1 biosynthesis, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3127
335659001169	FtsX-like permease family; Region: FtsX; pfam02687
335659001170	FtsX-like permease family; Region: FtsX; pfam02687
335659001171	ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255
335659001172	Predicted ABC-type transport system involved in lysophospholipase L1 biosynthesis, ATPase component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG4181
335659001173	Walker A/P-loop; other site
335659001174	ATP binding site [chemical binding]; other site
335659001175	Q-loop/lid; other site
335659001176	ABC transporter signature motif; other site
335659001177	Walker B; other site
335659001178	D-loop; other site
335659001179	H-loop/switch region; other site
335659001180	Lysophospholipase L1-like subgroup of SGNH-hydrolases. The best characterized member in this family is TesA, an E. coli periplasmic protein with thioesterase, esterase, arylesterase, protease and lysophospholipase activity; Region: Lysophospholipase_L1_like; cd01822
335659001181	active site
335659001182	catalytic triad [active]
335659001183	oxyanion hole [active]
335659001184	switch loop; other site
335659001185	2'-5' RNA ligase; Region: 2_5_ligase; TIGR02258
335659001186	LigT like Phosphoesterase; Region: LigT_PEase; pfam02834
335659001187	LigT like Phosphoesterase; Region: LigT_PEase; pfam02834
335659001188	Predicted ATPase [General function prediction only]; Region: COG1485
335659001189	malate dehydrogenase; Reviewed; Region: PRK06223
335659001190	L-lactate dehydrogenase-like malate dehydrogenase proteins; Region: LDH-like_MDH; cd01339
335659001191	NAD(P) binding site [chemical binding]; other site
335659001192	dimer interface [polypeptide binding]; other site
335659001193	tetramer (dimer of dimers) interface [polypeptide binding]; other site
335659001194	substrate binding site [chemical binding]; other site
335659001195	succinyl-CoA synthetase subunit beta; Provisional; Region: sucC; PRK00696
335659001196	ATP-grasp domain; Region: ATP-grasp_2; pfam08442
335659001197	CoA-ligase; Region: Ligase_CoA; pfam00549
335659001198	Protein of unknown function (DUF1579); Region: DUF1579; pfam07617
335659001199	succinyl-CoA synthetase subunit alpha; Validated; Region: PRK05678
335659001200	CoA binding domain; Region: CoA_binding; smart00881
335659001201	CoA-ligase; Region: Ligase_CoA; pfam00549
335659001202	2-oxoglutarate dehydrogenase E1 component; Reviewed; Region: sucA; PRK09404
335659001203	Thiamine pyrophosphate (TPP) family, E1 of OGDC-like subfamily, TPP-binding module; composed of proteins similar to the E1 component of the 2-oxoglutarate dehydrogenase multienzyme complex (OGDC). OGDC catalyzes the oxidative decarboxylation of...; Region: TPP_E1_OGDC_like; cd02016
335659001204	TPP-binding site [chemical binding]; other site
335659001205	Transketolase, pyrimidine binding domain; Region: Transket_pyr; pfam02779
335659001206	dimer interface [polypeptide binding]; other site
335659001207	PYR/PP interface [polypeptide binding]; other site
335659001208	TPP binding site [chemical binding]; other site
335659001209	dihydrolipoamide succinyltransferase; Validated; Region: PRK05704
335659001210	Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849
335659001211	E3 interaction surface; other site
335659001212	lipoyl attachment site [posttranslational modification]; other site
335659001213	e3 binding domain; Region: E3_binding; pfam02817
335659001214	2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198
335659001215	D-mannonate oxidoreductase; Provisional; Region: PRK08277
335659001216	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
335659001217	NAD(P) binding site [chemical binding]; other site
335659001218	active site
335659001219	dihydrolipoamide dehydrogenase; Validated; Region: PRK06292
335659001220	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
335659001221	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
335659001222	Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852
335659001223	Domain of unknown function (DUF4337); Region: DUF4337; pfam14235
335659001224	site-specific tyrosine recombinase XerC; Reviewed; Region: xerC; PRK00236
335659001225	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
335659001226	active site
335659001227	DNA binding site [nucleotide binding]
335659001228	Int/Topo IB signature motif; other site
335659001229	primosome assembly protein PriA; Validated; Region: PRK05580
335659001230	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
335659001231	ATP binding site [chemical binding]; other site
335659001232	putative Mg++ binding site [ion binding]; other site
335659001233	helicase superfamily c-terminal domain; Region: HELICc; smart00490
335659001234	Lipoproteins [Cell envelope biogenesis, outer membrane]; Region: RlpA; COG0797
335659001235	Rare lipoprotein A (RlpA)-like double-psi beta-barrel; Region: DPBB_1; pfam03330
335659001236	F0F1 ATP synthase subunit delta; Validated; Region: PRK05758
335659001237	ATP synthase delta (OSCP) subunit; Region: OSCP; pfam00213
335659001238	F0F1 ATP synthase subunit alpha; Validated; Region: PRK09281
335659001239	ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874
335659001240	F1 ATP synthase alpha, central domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a proton gradient to...; Region: F1_ATPase_alpha; cd01132
335659001241	beta subunit interaction interface [polypeptide binding]; other site
335659001242	Walker A motif; other site
335659001243	ATP binding site [chemical binding]; other site
335659001244	Walker B motif; other site
335659001245	ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306
335659001246	mitochondrial ATP synthase gamma subunit; Region: F1-ATPase_gamma; cd12151
335659001247	core domain interface [polypeptide binding]; other site
335659001248	delta subunit interface [polypeptide binding]; other site
335659001249	epsilon subunit interface [polypeptide binding]; other site
335659001250	F0F1 ATP synthase subunit beta; Validated; Region: PRK09280
335659001251	ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874
335659001252	F1 ATP synthase beta subunit, nucleotide-binding domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a...; Region: F1-ATPase_beta; cd01133
335659001253	alpha subunit interaction interface [polypeptide binding]; other site
335659001254	Walker A motif; other site
335659001255	ATP binding site [chemical binding]; other site
335659001256	Walker B motif; other site
335659001257	inhibitor binding site; inhibition site
335659001258	ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306
335659001259	F0F1 ATP synthase subunit epsilon; Provisional; Region: atpC; PRK13448
335659001260	mitochondrial ATP synthase delta subunit; Region: F1-ATPase_delta; cd12152
335659001261	gamma subunit interface [polypeptide binding]; other site
335659001262	epsilon subunit interface [polypeptide binding]; other site
335659001263	LBP interface [polypeptide binding]; other site
335659001264	Diadenosine tetraphosphate (Ap4A) hydrolase is a member of the Nudix hydrolase superfamily. Members of this family are well represented in a variety of prokaryotic and eukaryotic organisms. Phylogenetic analysis reveals two distinct subgroups where plant...; Region: Ap4A_hydrolase_plant_like; cd03671
335659001265	putative active site [active]
335659001266	Ap4A binding site [chemical binding]; other site
335659001267	nudix motif; other site
335659001268	putative metal binding site [ion binding]; other site
335659001269	Diadenosine tetraphosphate (Ap4A) hydrolase is a member of the Nudix hydrolase superfamily. Members of this family are well represented in a variety of prokaryotic and eukaryotic organisms. Phylogenetic analysis reveals two distinct subgroups where plant...; Region: Ap4A_hydrolase_plant_like; cd03671
335659001270	putative active site [active]
335659001271	Ap4A binding site [chemical binding]; other site
335659001272	nudix motif; other site
335659001273	putative metal binding site [ion binding]; other site
335659001274	Putative catalytic domain of family 2 polysaccharide deacetylases (DACs) from bacteria; Region: CE4_DAC2; cd10936
335659001275	putative active site [active]
335659001276	NodB motif; other site
335659001277	Periplasmic protease [Cell envelope biogenesis, outer membrane]; Region: Prc; COG0793
335659001278	C-terminal processing peptidase family S41; Region: Peptidase_S41; cl02526
335659001279	PDZ domain of C-terminal processing-, tail-specific-, and tricorn proteases, which function in posttranslational protein processing, maturation, and disassembly or degradation, in Bacteria, Archaea, and plant chloroplasts. May be responsible for...; Region: PDZ_CTP_protease; cd00988
335659001280	protein binding site [polypeptide binding]; other site
335659001281	C-terminal processing peptidase; serine protease family S41; Region: Peptidase_S41_CPP; cd07560
335659001282	Catalytic dyad [active]
335659001283	Membrane-bound metallopeptidase [Cell division and chromosome partitioning]; Region: COG4942
335659001284	Peptidase family M23; Region: Peptidase_M23; pfam01551
335659001285	rRNA large subunit methyltransferase; Provisional; Region: PRK00103
335659001286	iojap-like ribosome-associated protein; Region: iojap_ybeB; TIGR00090
335659001287	nicotinic acid mononucleotide adenylyltransferase; Provisional; Region: nadD; PRK00071
335659001288	Nicotinamide/nicotinate mononucleotide adenylyltransferase; Region: NMNAT; cd02165
335659001289	active site
335659001290	(T/H)XGH motif; other site
335659001291	Gamma-glutamyl phosphate reductase (GPR), aldehyde dehydrogenase families 18 and 19; Region: ALDH_F18-19_ProA-GPR; cd07079
335659001292	putative catalytic cysteine [active]
335659001293	Autotransporter-associated beta strand repeat; Region: Autotrns_rpt; pfam12951
335659001294	Autotransporter-associated beta strand repeat; Region: Autotrns_rpt; pfam12951
335659001295	Uncharacterized protein with a C-terminal OMP (outer membrane protein) domain [Function unknown]; Region: COG4625
335659001296	Autotransporter-associated beta strand repeat; Region: Autotrns_rpt; pfam12951
335659001297	Autotransporter beta-domain; Region: Autotransporter; pfam03797
335659001298	gamma-glutamyl kinase; Provisional; Region: PRK05429
335659001299	AAK_G5K_ProB: Glutamate-5-kinase (G5K) catalyzes glutamate-dependent ATP cleavage; G5K transfers the terminal phosphoryl group of ATP to the gamma-carboxyl group of glutamate, in the first and controlling step of proline (and, in mammals, ornithine)...; Region: AAK_G5K_ProB; cd04242
335659001300	nucleotide binding site [chemical binding]; other site
335659001301	homotetrameric interface [polypeptide binding]; other site
335659001302	putative phosphate binding site [ion binding]; other site
335659001303	putative allosteric binding site; other site
335659001304	PUA domain; Region: PUA; pfam01472
335659001305	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3181
335659001306	Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119
335659001307	Sulfatase; Region: Sulfatase; cl17466
335659001308	GTPase CgtA; Reviewed; Region: obgE; PRK12299
335659001309	GTP1/OBG; Region: GTP1_OBG; pfam01018
335659001310	Obg GTPase; Region: Obg; cd01898
335659001311	G1 box; other site
335659001312	GTP/Mg2+ binding site [chemical binding]; other site
335659001313	Switch I region; other site
335659001314	G2 box; other site
335659001315	G3 box; other site
335659001316	Switch II region; other site
335659001317	G4 box; other site
335659001318	G5 box; other site
335659001319	(R)-hydratase [(R)-specific enoyl-CoA hydratase]. Catalyzes the hydration of trans-2-enoyl CoA to (R)-3-hydroxyacyl-CoA as part of the PHA (polyhydroxyalkanoate) biosynthetic pathway.  The structure of the monomer includes a five-strand antiparallel...; Region: R_hydratase_like; cd03441
335659001320	active site
335659001321	catalytic site [active]
335659001322	Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697
335659001323	Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302
335659001324	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182
335659001325	50S ribosomal protein L27; Validated; Region: rpmA; PRK05435
335659001326	50S ribosomal protein L21/unknown domain fusion protein; Provisional; Region: PRK12278
335659001327	50S ribosomal protein L21; Validated; Region: rplU; PRK05573
335659001328	Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940
335659001329	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012
335659001330	nucleotide binding site [chemical binding]; other site
335659001331	Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596
335659001332	Predicted membrane protein (DUF2157); Region: DUF2157; cl10480
335659001333	GDYXXLXY protein; Region: GDYXXLXY; pfam14345
335659001334	ATP-grasp domain; Region: ATP-grasp_4; cl17255
335659001335	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
335659001336	Response regulator receiver domain; Region: Response_reg; pfam00072
335659001337	active site
335659001338	phosphorylation site [posttranslational modification]
335659001339	intermolecular recognition site; other site
335659001340	dimerization interface [polypeptide binding]; other site
335659001341	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
335659001342	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
335659001343	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
335659001344	DNA binding residues [nucleotide binding]
335659001345	dimerization interface [polypeptide binding]; other site
335659001346	Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cl00086
335659001347	cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664
335659001348	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
335659001349	ligand binding site [chemical binding]; other site
335659001350	flexible hinge region; other site
335659001351	Crp-like helix-turn-helix domain; Region: HTH_Crp_2; pfam13545
335659001352	cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664
335659001353	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cl00047
335659001354	Crp-like helix-turn-helix domain; Region: HTH_Crp_2; pfam13545
335659001355	Response regulator receiver domain; Region: Response_reg; pfam00072
335659001356	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
335659001357	active site
335659001358	phosphorylation site [posttranslational modification]
335659001359	intermolecular recognition site; other site
335659001360	dimerization interface [polypeptide binding]; other site
335659001361	Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088
335659001362	putative binding surface; other site
335659001363	active site
335659001364	Chemotaxis protein histidine kinase and related kinases [Cell motility and secretion / Signal transduction mechanisms]; Region: CheA; COG0643
335659001365	Signal transducing histidine kinase, homodimeric domain; Region: H-kinase_dim; pfam02895
335659001366	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
335659001367	ATP binding site [chemical binding]; other site
335659001368	Mg2+ binding site [ion binding]; other site
335659001369	G-X-G motif; other site
335659001370	CheA regulatory domain; CheA is a histidine protein kinase present in bacteria and archea. Activated by the chemotaxis receptor a histidine phosphoryl group from CheA is passed directly to an aspartate in the response regulator CheY. This signalling...; Region: CheA_reg; cd00731
335659001371	CheW-like domain; Region: CheW; pfam01584
335659001372	Response regulator receiver domain; Region: Response_reg; pfam00072
335659001373	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
335659001374	active site
335659001375	phosphorylation site [posttranslational modification]
335659001376	intermolecular recognition site; other site
335659001377	dimerization interface [polypeptide binding]; other site
335659001378	CheW-like domain. CheW proteins are part of the chemotaxis signalling mechanism in bacteria. CheW interacts with the methyl accepting chemotaxis proteins (MCPs) and relays signals to CheY, which affects flageller rotation. This family includes CheW and...; Region: CheW_like; cl00256
335659001379	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
335659001380	Response regulator receiver domain; Region: Response_reg; pfam00072
335659001381	active site
335659001382	phosphorylation site [posttranslational modification]
335659001383	intermolecular recognition site; other site
335659001384	dimerization interface [polypeptide binding]; other site
335659001385	Methylase of chemotaxis methyl-accepting proteins [Cell motility and secretion / Signal transduction mechanisms]; Region: CheR; COG1352
335659001386	CheR methyltransferase, all-alpha domain; Region: CheR_N; pfam03705
335659001387	CheR methyltransferase, SAM binding domain; Region: CheR; pfam01739
335659001388	Response regulator receiver domain; Region: Response_reg; pfam00072
335659001389	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
335659001390	active site
335659001391	phosphorylation site [posttranslational modification]
335659001392	intermolecular recognition site; other site
335659001393	dimerization interface [polypeptide binding]; other site
335659001394	Response regulator [Signal transduction mechanisms]; Region: TtrR; COG4566
335659001395	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
335659001396	active site
335659001397	phosphorylation site [posttranslational modification]
335659001398	intermolecular recognition site; other site
335659001399	dimerization interface [polypeptide binding]; other site
335659001400	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
335659001401	DNA binding residues [nucleotide binding]
335659001402	dimerization interface [polypeptide binding]; other site
335659001403	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
335659001404	dimerization interface [polypeptide binding]; other site
335659001405	PAS domain S-box; Region: sensory_box; TIGR00229
335659001406	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
335659001407	putative active site [active]
335659001408	heme pocket [chemical binding]; other site
335659001409	PAS domain S-box; Region: sensory_box; TIGR00229
335659001410	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
335659001411	putative active site [active]
335659001412	heme pocket [chemical binding]; other site
335659001413	PAS domain S-box; Region: sensory_box; TIGR00229
335659001414	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
335659001415	putative active site [active]
335659001416	heme pocket [chemical binding]; other site
335659001417	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
335659001418	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
335659001419	dimer interface [polypeptide binding]; other site
335659001420	phosphorylation site [posttranslational modification]
335659001421	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
335659001422	ATP binding site [chemical binding]; other site
335659001423	G-X-G motif; other site
335659001424	Response regulator receiver domain; Region: Response_reg; pfam00072
335659001425	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
335659001426	active site
335659001427	phosphorylation site [posttranslational modification]
335659001428	intermolecular recognition site; other site
335659001429	dimerization interface [polypeptide binding]; other site
335659001430	Response regulator receiver domain; Region: Response_reg; pfam00072
335659001431	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
335659001432	active site
335659001433	phosphorylation site [posttranslational modification]
335659001434	intermolecular recognition site; other site
335659001435	dimerization interface [polypeptide binding]; other site
335659001436	Transcriptional regulators [Transcription]; Region: GntR; COG1802
335659001437	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
335659001438	DNA-binding site [nucleotide binding]; DNA binding site
335659001439	FCD domain; Region: FCD; pfam07729
335659001440	NMT1-like family; Region: NMT1_2; pfam13379
335659001441	ABC transporter, substrate-binding protein, aliphatic sulfonates family; Region: SsuA_fam; TIGR01728
335659001442	ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116
335659001443	ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293
335659001444	Walker A/P-loop; other site
335659001445	ATP binding site [chemical binding]; other site
335659001446	Q-loop/lid; other site
335659001447	ABC transporter signature motif; other site
335659001448	Walker B; other site
335659001449	D-loop; other site
335659001450	H-loop/switch region; other site
335659001451	ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600
335659001452	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
335659001453	putative PBP binding loops; other site
335659001454	dimer interface [polypeptide binding]; other site
335659001455	ABC-ATPase subunit interface; other site
335659001456	dihydroxy-acid dehydratase; Provisional; Region: PRK13016
335659001457	hypothetical protein; Validated; Region: PRK08245
335659001458	Conserved protein/domain typically associated with flavoprotein oxygenases, DIM6/NTAB family [General function prediction only]; Region: COG1853
335659001459	Protease II [Amino acid transport and metabolism]; Region: PtrB; COG1770
335659001460	Adenovirus E1B 19K protein / small t-antigen; Region: Adeno_E1B_19K; pfam01691
335659001461	Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326
335659001462	Predicted membrane protein involved in D-alanine export [Cell envelope biogenesis, outer membrane]; Region: DltB; COG1696
335659001463	Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321
335659001464	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
335659001465	catalytic residue [active]
335659001466	Micrococcal nuclease (thermonuclease) homologs [DNA replication, recombination, and repair]; Region: COG1525
335659001467	Staphylococcal nuclease homologues. SNase homologues are found in bacteria, archaea, and eukaryotes. They contain no disufide bonds; Region: SNc; cl00140
335659001468	Catalytic site; other site
335659001469	Caspase domain; Region: Peptidase_C14; pfam00656
335659001470	M14 family of metallocarboxypeptidases and related proteins; Region: Peptidase_M14_like; cl11393
335659001471	HlyD family secretion protein; Region: HlyD_3; pfam13437
335659001472	6-phosphogluconolactonase; Provisional; Region: PRK11028
335659001473	succinate CoA transferase; Region: YgfH_subfam; TIGR03458
335659001474	Acetyl-CoA hydrolase/transferase N-terminal domain; Region: AcetylCoA_hydro; pfam02550
335659001475	Acetyl-CoA hydrolase/transferase C-terminal domain; Region: AcetylCoA_hyd_C; pfam13336
335659001476	30S ribosomal protein S21; Reviewed; Region: rpsU; PRK00270
335659001477	PAS fold; Region: PAS_7; pfam12860
335659001478	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
335659001479	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
335659001480	metal binding site [ion binding]; metal-binding site
335659001481	active site
335659001482	I-site; other site
335659001483	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
335659001484	Y_Y_Y domain; Region: Y_Y_Y; pfam07495
335659001485	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
335659001486	LTXXQ motif family protein; Region: LTXXQ; pfam07813
335659001487	LTXXQ motif family protein; Region: LTXXQ; pfam07813
335659001488	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
335659001489	dimerization interface [polypeptide binding]; other site
335659001490	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
335659001491	GAF domain; Region: GAF_3; pfam13492
335659001492	Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114
335659001493	cyclase homology domain; Region: CHD; cd07302
335659001494	nucleotidyl binding site; other site
335659001495	metal binding site [ion binding]; metal-binding site
335659001496	dimer interface [polypeptide binding]; other site
335659001497	AsmA family; Region: AsmA; pfam05170
335659001498	AsmA-like C-terminal region; Region: AsmA_2; pfam13502
335659001499	cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664
335659001500	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
335659001501	ligand binding site [chemical binding]; other site
335659001502	flexible hinge region; other site
335659001503	Crp-like helix-turn-helix domain; Region: HTH_Crp_2; pfam13545
335659001504	Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841
335659001505	HlyD family secretion protein; Region: HlyD_3; pfam13437
335659001506	Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185
335659001507	Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885
335659001508	ligand binding site [chemical binding]; other site
335659001509	Caspase domain; Region: Peptidase_C14; pfam00656
335659001510	TPR repeat; Region: TPR_11; pfam13414
335659001511	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
335659001512	binding surface
335659001513	TPR motif; other site
335659001514	TPR repeat; Region: TPR_11; pfam13414
335659001515	Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849
335659001516	helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347
335659001517	MarR family; Region: MarR_2; pfam12802
335659001518	MarR family; Region: MarR_2; cl17246
335659001519	FAD-dependent oxidoreductase; Provisional; Region: PRK08132
335659001520	ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314
335659001521	Protein of unknown function (DUF2783); Region: DUF2783; pfam10932
335659001522	Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849
335659001523	homogentisate 1,2-dioxygenase; Provisional; Region: PRK05341
335659001524	fumarylacetoacetase; Region: PLN02856
335659001525	Domain of unknown function (DUF1969); Region: DUF1969; pfam09298
335659001526	Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557
335659001527	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3813
335659001528	Protein of unknown function (DUF1272); Region: DUF1272; pfam06906
335659001529	Transcriptional regulators [Transcription]; Region: Lrp; COG1522
335659001530	AsnC-type helix-turn-helix domain; Region: HTH_AsnC-type; pfam13404
335659001531	putative DNA binding site [nucleotide binding]; other site
335659001532	putative Zn2+ binding site [ion binding]; other site
335659001533	AsnC family; Region: AsnC_trans_reg; pfam01037
335659001534	4-hydroxyphenylpyruvate dioxygenase and related hemolysins [Amino acid transport and metabolism / General function prediction only]; Region: COG3185
335659001535	N-terminal domain of 4-hydroxyphenylpyruvate dioxygenase (HPPD) and hydroxymandelate Synthase (HmaS); Region: HPPD_N_like; cd08342
335659001536	dimer interface [polypeptide binding]; other site
335659001537	C-terminal domain of 4-hydroxyphenylpyruvate dioxygenase (HppD) and hydroxymandelate Synthase (HmaS); Region: HPPD_C_like; cd07250
335659001538	active site
335659001539	Fe binding site [ion binding]; other site
335659001540	Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804
335659001541	CoA-transferase family III; Region: CoA_transf_3; pfam02515
335659001542	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM/CutM homologs [Energy production and conversion]; Region: CoxM; COG1319
335659001543	CO dehydrogenase flavoprotein C-terminal domain; Region: CO_deh_flav_C; smart01092
335659001544	Aerobic-type carbon monoxide dehydrogenase, large subunit CoxL/CutL homologs [Energy production and conversion]; Region: CoxL; COG1529
335659001545	Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; smart01008
335659001546	Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738
335659001547	Aerobic-type carbon monoxide dehydrogenase, small subunit CoxS/CutS homologs [Energy production and conversion]; Region: CoxS; COG2080
335659001548	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
335659001549	catalytic loop [active]
335659001550	iron binding site [ion binding]; other site
335659001551	[2Fe-2S] binding domain; Region: Fer2_2; pfam01799
335659001552	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
335659001553	dimerization interface [polypeptide binding]; other site
335659001554	Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283
335659001555	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
335659001556	dimer interface [polypeptide binding]; other site
335659001557	putative CheW interface [polypeptide binding]; other site
335659001558	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
335659001559	dimerization interface [polypeptide binding]; other site
335659001560	Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283
335659001561	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
335659001562	dimer interface [polypeptide binding]; other site
335659001563	putative CheW interface [polypeptide binding]; other site
335659001564	Protein of unknown function (DUF3175); Region: DUF3175; pfam11373
335659001565	benzoate transport; Region: 2A0115; TIGR00895
335659001566	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
335659001567	putative substrate translocation pore; other site
335659001568	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
335659001569	trehalose-6-phosphate phosphatase; Provisional; Region: PRK10187; cl17105
335659001570	HAD-superfamily hydrolase, subfamily IIB; Region: HAD-SF-IIB; TIGR01484
335659001571	alpha,alpha-trehalose-phosphate synthase [UDP-forming]; Region: trehalose_OtsA; TIGR02400
335659001572	Trehalose-6-Phosphate Synthase (TPS) is a glycosyltransferase that catalyses the synthesis of alpha,alpha-1,1-trehalose-6-phosphate from glucose-6-phosphate using a UDP-glucose donor. It is a key enzyme in the trehalose synthesis pathway. Trehalose is a...; Region: GT1_TPS; cd03788
335659001573	active site
335659001574	homotetramer interface [polypeptide binding]; other site
335659001575	The nitrogenase enzyme system catalyzes the ATP-dependent reduction of dinitrogen to ammonia.  This group contains both alpha and beta subunits of component 1 of the three known genetically distinct types of nitrogenase systems: a molybdenum-dependent; Region: Oxidoreductase_nitrogenase; cl02775
335659001576	ankyrin repeats;  ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204
335659001577	Ankyrin repeats (3 copies); Region: Ank_2; pfam12796
335659001578	Prim_Pol: Primase-polymerase (primpol) domain of the type found in bifunctional replicases from archaeal plasmids, including ORF904 protein of the crenarchaeal plasmid pRN1 from Sulfolobus islandicus (pRN1 primpol). These primpol domains belong to the...; Region: Prim_Pol; cd04859
335659001579	polymerase nucleotide-binding site; other site
335659001580	DNA-binding residues [nucleotide binding]; DNA binding site
335659001581	nucleotide binding site [chemical binding]; other site
335659001582	primase nucleotide-binding site [nucleotide binding]; other site
335659001583	Primase C terminal 2 (PriCT-2); Region: PriCT_2; pfam08707
335659001584	Helix-turn-helix domain; Region: HTH_17; cl17695
335659001585	integrase; Provisional; Region: PRK09692
335659001586	Bacteriophage P4 integrase. P4-like integrases are found in temperate bacteriophages, integrative plasmids, pathogenicity and symbiosis islands, and other mobile genetic elements.  They share the same fold in their catalytic domain and the overall...; Region: INT_P4; cd00801
335659001587	active site
335659001588	Int/Topo IB signature motif; other site
335659001589	Predicted hydrolase (HAD superfamily) [General function prediction only]; Region: COG1011
335659001590	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
335659001591	motif II; other site
335659001592	DNA-sulfur modification-associated; Region: DndB; pfam14072
335659001593	DGQHR domain; Region: DGQHR; TIGR03187
335659001594	Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961
335659001595	Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and...; Region: SR_ResInv; cd03768
335659001596	Presynaptic Site I dimer interface [polypeptide binding]; other site
335659001597	catalytic residues [active]
335659001598	Synaptic Antiparallel dimer interface [polypeptide binding]; other site
335659001599	Synaptic Flat tetramer interface [polypeptide binding]; other site
335659001600	Synaptic Site I dimer interface [polypeptide binding]; other site
335659001601	DNA binding site [nucleotide binding]
335659001602	Recombinase; Region: Recombinase; pfam07508
335659001603	Recombinase zinc beta ribbon domain; Region: Zn_ribbon_recom; pfam13408
335659001604	Protein of unknown function (DUF2924); Region: DUF2924; pfam11149
335659001605	Stage 0 sporulation protein J (antagonist of Soj) containing ParB-like nuclease domain [Transcription]; Region: Spo0J; COG1475
335659001606	ParB-like nuclease domain; Region: ParBc; pfam02195
335659001607	DNA modification methylase [DNA replication, recombination, and repair]; Region: COG0863
335659001608	DNA methylase; Region: N6_N4_Mtase; pfam01555
335659001609	Phage terminase, small subunit; Region: Terminase_4; pfam05119
335659001610	Phage terminase, small subunit; Region: Terminase_4; pfam05119
335659001611	DGQHR domain; Region: DGQHR; TIGR03187
335659001612	DNA-sulfur modification-associated; Region: DndB; cl17621
335659001613	Queuine/archaeosine tRNA-ribosyltransferase [Translation, ribosomal structure and biogenesis]; Region: Tgt; COG0343
335659001614	DGQHR domain; Region: DGQHR; TIGR03187
335659001615	DNA phosphorothioation-associated DGQHR protein 1; Region: DGQHR_dnd_1; TIGR04172
335659001616	ExsB is a transcription regulator related protein. It is a subfamily of a Adenosine nucleotide binding superfamily of proteins. This protein family is represented by a single member in nearly every completed large (> 1000 genes) prokaryotic genome. In...; Region: ExsB; cd01995
335659001617	Ligand Binding Site [chemical binding]; other site
335659001618	Organic radical activating enzymes [Posttranslational modification, protein turnover, chaperones]; Region: NrdG; COG0602
335659001619	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
335659001620	FeS/SAM binding site; other site
335659001621	6-pyruvoyl tetrahydropterin synthase; Region: PTPS; pfam01242
335659001622	active site
335659001623	Predicted nuclease (RecB family) [General function prediction only]; Region: COG2251
335659001624	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
335659001625	ATP-binding site [chemical binding]; other site
335659001626	AAA ATPase domain; Region: AAA_16; pfam13191
335659001627	DEAD-like helicases superfamily; Region: DEXDc; smart00487
335659001628	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
335659001629	ATP binding site [chemical binding]; other site
335659001630	putative Mg++ binding site [ion binding]; other site
335659001631	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
335659001632	nucleotide binding region [chemical binding]; other site
335659001633	ATP-binding site [chemical binding]; other site
335659001634	SAM domain (Sterile alpha motif); Region: SAM_2; pfam07647
335659001635	SAM (Sterile alpha motif ); Region: SAM_superfamily; cd09487
335659001636	Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114
335659001637	cyclase homology domain; Region: CHD; cd07302
335659001638	nucleotidyl binding site; other site
335659001639	metal binding site [ion binding]; metal-binding site
335659001640	dimer interface [polypeptide binding]; other site
335659001641	Predicted ATPase [General function prediction only]; Region: COG3899
335659001642	AAA ATPase domain; Region: AAA_16; pfam13191
335659001643	Predicted ATPase [General function prediction only]; Region: COG3903
335659001644	putative TOMM peptide; Region: TOMM_nitrile_2; TIGR04351
335659001645	short chain dehydrogenase; Provisional; Region: PRK06523
335659001646	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
335659001647	NAD(P) binding site [chemical binding]; other site
335659001648	active site
335659001649	SnoaL-like domain; Region: SnoaL_2; pfam12680
335659001650	Predicted transcriptional regulators [Transcription]; Region: COG1733
335659001651	HxlR-like helix-turn-helix; Region: HxlR; pfam01638
335659001652	Transcriptional regulator [Transcription]; Region: LysR; COG0583
335659001653	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
335659001654	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
335659001655	dimerization interface [polypeptide binding]; other site
335659001656	Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814
335659001657	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
335659001658	putative substrate translocation pore; other site
335659001659	amidase; Provisional; Region: PRK07487
335659001660	Amidase; Region: Amidase; cl11426
335659001661	O-acetylhomoserine sulfhydrylase [Amino acid transport and metabolism]; Region: MET17; COG2873
335659001662	CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614
335659001663	homodimer interface [polypeptide binding]; other site
335659001664	substrate-cofactor binding pocket; other site
335659001665	pyridoxal 5'-phosphate binding site [chemical binding]; other site
335659001666	catalytic residue [active]
335659001667	homoserine O-succinyltransferase; Provisional; Region: PRK05368
335659001668	Type 1 glutamine amidotransferase (GATase1)-like domain found in homoserine trans-succinylase (HTS); Region: GATase1_HTS; cd03131
335659001669	proposed active site lysine [active]
335659001670	conserved cys residue [active]
335659001671	Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726
335659001672	Putative catalytic NodB homology domain of gellan lyase and similar proteins; Region: CE4_GLA_like_6s; cd10967
335659001673	putative active site [active]
335659001674	putative metal binding site [ion binding]; other site
335659001675	ATP-dependent DNA helicase RecQ; Region: recQ; TIGR01389
335659001676	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
335659001677	ATP binding site [chemical binding]; other site
335659001678	putative Mg++ binding site [ion binding]; other site
335659001679	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
335659001680	nucleotide binding region [chemical binding]; other site
335659001681	ATP-binding site [chemical binding]; other site
335659001682	This DNA-binding domain is found in the RecQ helicase among others and has a helix-turn-helix structure; Region: RQC; smart00956
335659001683	HRDC domain; Region: HRDC; pfam00570
335659001684	1-aminocyclopropane-1-carboxylate deaminase [Amino acid transport and metabolism]; Region: Acd; COG2515
335659001685	Aminocyclopropane-1-carboxylate deaminase (ACCD): Pyridoxal phosphate (PLP)-dependent enzyme which catalyzes the conversion of 1-aminocyclopropane-L-carboxylate (ACC), a precursor of the plant hormone ethylene, to alpha-ketobutyrate and ammonia; Region: ACCD; cd06449
335659001686	pyridoxal 5'-phosphate binding site [chemical binding]; other site
335659001687	catalytic residue [active]
335659001688	Transcriptional regulators [Transcription]; Region: Lrp; COG1522
335659001689	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
335659001690	putative DNA binding site [nucleotide binding]; other site
335659001691	putative Zn2+ binding site [ion binding]; other site
335659001692	AsnC family; Region: AsnC_trans_reg; pfam01037
335659001693	Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031
335659001694	Tryptophan synthase beta superfamily (fold type II); this family of pyridoxal phosphate (PLP)-dependent enzymes catalyzes beta-replacement and beta-elimination reactions. This CD corresponds to aminocyclopropane-1-carboxylate deaminase (ACCD), tryptophan...; Region: Trp-synth-beta_II; cl00342
335659001695	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
335659001696	catalytic residue [active]
335659001697	Carboxymuconolactone decarboxylase family; Region: CMD; cl00460
335659001698	Uncharacterized conserved protein [Function unknown]; Region: COG2128
335659001699	Esterases and lipases (includes fungal lipases, cholinesterases, etc.)  These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312
335659001700	alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859
335659001701	substrate binding pocket [chemical binding]; other site
335659001702	aminotransferase; Provisional; Region: PRK13356
335659001703	Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115
335659001704	homodimer interface [polypeptide binding]; other site
335659001705	substrate-cofactor binding pocket; other site
335659001706	pyridoxal 5'-phosphate binding site [chemical binding]; other site
335659001707	catalytic residue [active]
335659001708	Methyltransferase domain; Region: Methyltransf_25; pfam13649
335659001709	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5394
335659001710	PHB/PHA accumulation regulator DNA-binding domain; Region: PHB_acc_N; pfam07879
335659001711	PHB accumulation regulatory domain; Region: PHB_acc; pfam05233
335659001712	putative acyltransferase; Provisional; Region: PRK05790
335659001713	Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751
335659001714	dimer interface [polypeptide binding]; other site
335659001715	active site
335659001716	acetoacetyl-CoA reductase; Region: AcAcCoA_reduct; TIGR01829
335659001717	beta-Keto acyl carrier protein reductase (BKR), involved in Type II FAS, classical (c) SDRs; Region: BKR_SDR_c; cd05333
335659001718	NAD(P) binding site [chemical binding]; other site
335659001719	homotetramer interface [polypeptide binding]; other site
335659001720	homodimer interface [polypeptide binding]; other site
335659001721	active site
335659001722	aromatic amino acid exporter; Provisional; Region: PRK11689
335659001723	EamA-like transporter family; Region: EamA; pfam00892
335659001724	Cupin superfamily (DUF985); Region: Cupin_5; pfam06172
335659001725	hydroxyacylglutathione hydrolase; Region: GSH_gloB; TIGR03413
335659001726	Methyltransferase domain; Region: Methyltransf_23; pfam13489
335659001727	Methyltransferase domain; Region: Methyltransf_11; pfam08241
335659001728	Domain of unknown function (DUF4167); Region: DUF4167; pfam13763
335659001729	N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase; Provisional; Region: PRK09328
335659001730	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
335659001731	S-adenosylmethionine binding site [chemical binding]; other site
335659001732	peptide chain release factor 2; Provisional; Region: PRK08787
335659001733	This domain is found in peptide chain release factors; Region: PCRF; smart00937
335659001734	RF-1 domain; Region: RF-1; pfam00472
335659001735	Signal transduction protein containing GAF and PtsI domains [Signal transduction mechanisms]; Region: PtsP; COG3605
335659001736	GAF domain; Region: GAF; pfam01590
335659001737	PEP-utilising enzyme, N-terminal; Region: PEP-utilisers_N; pfam05524
335659001738	PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391
335659001739	PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896
335659001740	aspartate kinase; Reviewed; Region: PRK06635
335659001741	AAK_AKii-LysC-BS: Amino Acid Kinase Superfamily (AAK), AKii; this CD includes the N-terminal catalytic aspartokinase (AK) domain of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis 168, and the lysine plus threonine-sensitive...; Region: AAK_AKii-LysC-BS; cd04261
335659001742	putative nucleotide binding site [chemical binding]; other site
335659001743	putative catalytic residues [active]
335659001744	putative Mg ion binding site [ion binding]; other site
335659001745	putative aspartate binding site [chemical binding]; other site
335659001746	ACT domains of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related proteins; Region: ACT_AKii-LysC-BS-like_1; cd04913
335659001747	putative allosteric regulatory site; other site
335659001748	ACT domains of the lysine-sensitive, aspartokinase (AK) isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related domains; Region: ACT_AKii-LysC-BS-like_2; cd04936
335659001749	putative allosteric regulatory residue; other site
335659001750	Bacterial PH domain; Region: DUF304; pfam03703
335659001751	bifunctional 3-demethylubiquinone-9 3-methyltransferase/ 2-octaprenyl-6-hydroxy phenol methylase; Provisional; Region: PRK05134
335659001752	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
335659001753	S-adenosylmethionine binding site [chemical binding]; other site
335659001754	Protein of unknown function (DUF1178); Region: DUF1178; pfam06676
335659001755	Predicted amidohydrolase [General function prediction only]; Region: COG0388
335659001756	Nit1, Nit 2, and related proteins, and the Nit1-like domain of NitFhit (class 10 nitrilases); Region: nit; cd07572
335659001757	putative active site [active]
335659001758	catalytic triad [active]
335659001759	dimer interface [polypeptide binding]; other site
335659001760	Glutaredoxin (GRX) family, GRX bacterial class 1 and 3 (b_1_3)-like subfamily; composed of bacterial GRXs, approximately 10 kDa in size, and proteins containing a GRX or GRX-like domain. GRX is a glutathione (GSH) dependent reductase, catalyzing the...; Region: GRX_GRXb_1_3_like; cd03418
335659001761	GSH binding site [chemical binding]; other site
335659001762	catalytic residues [active]
335659001763	Predicted amidophosphoribosyltransferases [General function prediction only]; Region: ComFC; COG1040
335659001764	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
335659001765	active site
335659001766	NIPSNAP; Region: NIPSNAP; pfam07978
335659001767	biotin biosynthesis protein BioC; Region: BioC; TIGR02072
335659001768	Methyltransferase domain; Region: Methyltransf_11; pfam08241
335659001769	The MutT pyrophosphohydrolase is a prototypical Nudix hydrolase that catalyzes the hydrolysis of nucleoside and deoxynucleoside triphosphates (NTPs and dNTPs) by substitution at a beta-phosphorus to yield a nucleotide monophosphate (NMP) and inorganic...; Region: MutT_pyrophosphohydrolase; cd03425
335659001770	active site
335659001771	8-oxo-dGMP binding site [chemical binding]; other site
335659001772	nudix motif; other site
335659001773	metal binding site [ion binding]; metal-binding site
335659001774	Ornithine acetyltransferase (OAT) family; also referred to as ArgJ. OAT catalyzes the first and fifth steps in arginine biosynthesis, coupling acetylation of glutamate with deacetylation of N-acetylornithine, which allows recycling of the acetyl group in...; Region: OAT; cd02152
335659001775	heterotetramer interface [polypeptide binding]; other site
335659001776	active site pocket [active]
335659001777	cleavage site
335659001778	peptidylprolyl isomerase; Provisional; Region: prsA; PRK00059
335659001779	PPIC-type PPIASE domain; Region: Rotamase; pfam00639
335659001780	preprotein translocase subunit SecA; Reviewed; Region: PRK12904
335659001781	SecA preprotein cross-linking domain; Region: SecA_PP_bind; smart00958
335659001782	SEC-C motif; Region: SEC-C; pfam02810
335659001783	helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347
335659001784	MarR family; Region: MarR_2; pfam12802
335659001785	Periplasmic binding protein; Region: Peripla_BP_6; pfam13458
335659001786	Type I periplasmic-binding protein of the nitrile hydratase (NHase) system that selectively converts nitriles to corresponding amides; Region: PBP1_NHase; cd06358
335659001787	putative ligand binding site [chemical binding]; other site
335659001788	amidase; Provisional; Region: PRK07235
335659001789	Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154
335659001790	Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582
335659001791	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
335659001792	TM-ABC transporter signature motif; other site
335659001793	Periplasmic binding protein; Region: Peripla_BP_6; pfam13458
335659001794	Type I periplasmic components of amide-binding protein (AmiC) and the active transport system for short-chain and urea (FmdDEF); Region: PBP1_AmiC_like; cd06331
335659001795	ligand binding site [chemical binding]; other site
335659001796	ABC-type branched-chain amino acid transport system, permease component [Amino acid transport and metabolism]; Region: LivM; COG4177
335659001797	Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581
335659001798	TM-ABC transporter signature motif; other site
335659001799	urea ABC transporter, ATP-binding protein UrtD; Region: urea_trans_UrtD; TIGR03411
335659001800	ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219
335659001801	Walker A/P-loop; other site
335659001802	ATP binding site [chemical binding]; other site
335659001803	Q-loop/lid; other site
335659001804	ABC transporter signature motif; other site
335659001805	Walker B; other site
335659001806	D-loop; other site
335659001807	H-loop/switch region; other site
335659001808	ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410
335659001809	ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224
335659001810	Walker A/P-loop; other site
335659001811	ATP binding site [chemical binding]; other site
335659001812	Q-loop/lid; other site
335659001813	ABC transporter signature motif; other site
335659001814	Walker B; other site
335659001815	D-loop; other site
335659001816	H-loop/switch region; other site
335659001817	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3034
335659001818	acetyl-CoA carboxylase carboxyltransferase subunit alpha; Validated; Region: PRK05724
335659001819	acetyl-CoA carboxylase carboxyltransferase alpha subunit; Provisional; Region: accA; CHL00198
335659001820	tyrosine recombinase XerD; Region: recomb_XerD; TIGR02225
335659001821	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
335659001822	active site
335659001823	DNA binding site [nucleotide binding]
335659001824	Int/Topo IB signature motif; other site
335659001825	shikimate kinase; Provisional; Region: PRK13946
335659001826	Shikimate kinase (SK) is the fifth enzyme in the shikimate pathway, a seven-step biosynthetic pathway which converts erythrose-4-phosphate to chorismic acid, found in bacteria, fungi and plants. Chorismic acid is a important intermediate in the synthesis...; Region: SK; cd00464
335659001827	ADP binding site [chemical binding]; other site
335659001828	magnesium binding site [ion binding]; other site
335659001829	putative shikimate binding site; other site
335659001830	Dehydroquinate synthase (DHQS) catalyzes the conversion of DAHP to DHQ in shikimate pathway for aromatic compounds synthesis; Region: DHQS; cd08195
335659001831	active site
335659001832	dimer interface [polypeptide binding]; other site
335659001833	metal binding site [ion binding]; metal-binding site
335659001834	Putative Mg2+ and Co2+ transporter CorB [Inorganic ion transport and metabolism]; Region: CorB; COG4536
335659001835	Domain of unknown function DUF21; Region: DUF21; pfam01595
335659001836	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590
335659001837	Transporter associated domain; Region: CorC_HlyC; smart01091
335659001838	Stress-induced morphogen (activity unknown) [Signal transduction mechanisms]; Region: BolA; COG0271
335659001839	DnaJ-class molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: CbpA; COG2214
335659001840	DnaJ domain or J-domain.  DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257
335659001841	HSP70 interaction site [polypeptide binding]; other site
335659001842	Bacillus subtilis (Bs) citrate synthase CS-I_like. CS catalyzes the condensation of acetyl coenzyme A (AcCoA) and oxalacetate (OAA) to form citrate and coenzyme A (CoA), the first step in the citric acid cycle (TCA or Krebs cycle). 2MCS catalyzes the...; Region: BsCS-I_like; cd06109
335659001843	dimer interface [polypeptide binding]; other site
335659001844	Citrate synthase; Region: Citrate_synt; pfam00285
335659001845	active site
335659001846	citrylCoA binding site [chemical binding]; other site
335659001847	oxalacetate/citrate binding site [chemical binding]; other site
335659001848	coenzyme A binding site [chemical binding]; other site
335659001849	catalytic triad [active]
335659001850	Helix-turn-helix domain; Region: HTH_17; pfam12728
335659001851	Citrate synthase (CS), citryl-CoA lyase (CCL), the C-terminal portion of the single-subunit type ATP-citrate lyase (ACL) and the C-terminal portion of the large subunit of the two-subunit type ACL. CS catalyzes the condensation of acetyl coenzyme A; Region: CS_ACL-C_CCL; cl00416
335659001852	Citrate synthase (CS) catalyzes the condensation of acetyl coenzyme A (AcCoA) and oxalacetate (OAA) to form citrate and coenzyme A (CoA), the first step in the oxidative citric acid cycle (TCA or Krebs cycle). Peroxisomal CS is involved in the glyoxylate...; Region: citrate_synt_like_2; cd06102
335659001853	Citrate synthase; Region: Citrate_synt; pfam00285
335659001854	dimer interface [polypeptide binding]; other site
335659001855	active site
335659001856	oxalacetate/citrate binding site [chemical binding]; other site
335659001857	citrylCoA binding site [chemical binding]; other site
335659001858	coenzyme A binding site [chemical binding]; other site
335659001859	catalytic triad [active]
335659001860	Transcriptional regulator [Transcription]; Region: LysR; COG0583
335659001861	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
335659001862	The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422
335659001863	putative effector binding pocket; other site
335659001864	dimerization interface [polypeptide binding]; other site
335659001865	Predicted dinucleotide-binding enzymes [General function prediction only]; Region: COG2085
335659001866	NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; pfam03807
335659001867	SnoaL-like domain; Region: SnoaL_2; pfam12680
335659001868	Citrate synthase (CS), citryl-CoA lyase (CCL), the C-terminal portion of the single-subunit type ATP-citrate lyase (ACL) and the C-terminal portion of the large subunit of the two-subunit type ACL. CS catalyzes the condensation of acetyl coenzyme A; Region: CS_ACL-C_CCL; cl00416
335659001869	FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784
335659001870	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
335659001871	active site
335659001872	phosphorylation site [posttranslational modification]
335659001873	intermolecular recognition site; other site
335659001874	dimerization interface [polypeptide binding]; other site
335659001875	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920
335659001876	HWE histidine kinase; Region: HWE_HK; smart00911
335659001877	Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586
335659001878	SNARE associated Golgi protein; Region: SNARE_assoc; cl00429
335659001879	cobaltochelatase, CobS subunit; Region: PD_CobS; TIGR01650
335659001880	Cobaltochelatase CobS subunit N terminal; Region: CobS_N; pfam12556
335659001881	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189
335659001882	Cobalamin biosynthesis protein CobT; Region: CobT; pfam06213
335659001883	cobaltochelatase, CobT subunit; Region: CobT; TIGR01651
335659001884	norD type: Denitrifying bacteria contain both membrane bound and periplasmic nitrate reductases. Denitrification plays a major role  in completing the nitrogen cycle by converting nitrate or nitrite to nitrogen gas. The pathway for microbial...; Region: vWA_norD_type; cd01454
335659001885	metal ion-dependent adhesion site (MIDAS); other site
335659001886	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4246
335659001887	Esterase-like activity of phytase; Region: Phytase-like; pfam13449
335659001888	NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902
335659001889	Old yellow enzyme (OYE) YqjM-like FMN binding domain. YqjM is involved in the oxidative stress response of Bacillus subtilis.  Like the other OYE members, each monomer of YqjM contains FMN as a non-covalently bound cofactor and uses NADPH as a reducing...; Region: OYE_YqiM_FMN; cd02932
335659001890	active site
335659001891	FMN binding site [chemical binding]; other site
335659001892	substrate binding site [chemical binding]; other site
335659001893	homotetramer interface [polypeptide binding]; other site
335659001894	catalytic residue [active]
335659001895	PilZ domain; Region: PilZ; pfam07238
335659001896	Uncharacterized conserved protein (DUF2235); Region: DUF2235; pfam09994
335659001897	Protein of unknown function (DUF1488); Region: DUF1488; pfam07369
335659001898	50S ribosomal protein L28; Reviewed; Region: rpmB; PRK00359
335659001899	Protein of unknown function (DUF3108); Region: DUF3108; pfam11306
335659001900	Superfamily II DNA and RNA helicases [DNA replication, recombination, and repair / Transcription / Translation, ribosomal structure and biogenesis]; Region: SrmB; COG0513
335659001901	DEAD/DEAH box helicase; Region: DEAD; pfam00270
335659001902	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
335659001903	nucleotide binding region [chemical binding]; other site
335659001904	ATP-binding site [chemical binding]; other site
335659001905	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
335659001906	RNA binding surface [nucleotide binding]; other site
335659001907	Ferredoxin [Energy production and conversion]; Region: COG1146
335659001908	4Fe-4S binding domain; Region: Fer4; pfam00037
335659001909	Domain of unknown function (DUF3470); Region: DUF3470; pfam11953
335659001910	Transcriptional regulators, similar to M. xanthus CarD [Transcription]; Region: COG1329
335659001911	Response regulator consisting of a CheY-like receiver domain and a Fis-type HTH domain [Signal transduction mechanisms / Transcription]; Region: COG4567
335659001912	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
335659001913	active site
335659001914	phosphorylation site [posttranslational modification]
335659001915	intermolecular recognition site; other site
335659001916	dimerization interface [polypeptide binding]; other site
335659001917	Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954
335659001918	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
335659001919	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
335659001920	dimer interface [polypeptide binding]; other site
335659001921	phosphorylation site [posttranslational modification]
335659001922	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
335659001923	ATP binding site [chemical binding]; other site
335659001924	Mg2+ binding site [ion binding]; other site
335659001925	G-X-G motif; other site
335659001926	SURF1 superfamily. Surf1/Shy1 has been implicated in the posttranslational steps of the biogenesis of the mitochondrially-encoded Cox1 subunit of cytochrome c oxidase (complex IV). Cytochrome c oxidase (complex IV), the terminal electron-transferring...; Region: SURF1; cd06662
335659001927	cytochrome o ubiquinol oxidase subunit IV; Region: CyoD; TIGR02847
335659001928	Ubiquinol oxidase subunit III subfamily. Ubiquinol oxidase, the terminal oxidase in the respiratory chains of aerobic bacteria, is a multi-chain transmembrane protein located in the cell membrane.  It catalyzes the reduction of O2 and simultaneously...; Region: Ubiquinol_oxidase_III; cd02863
335659001929	Subunit I/III interface [polypeptide binding]; other site
335659001930	Subunit III/IV interface [polypeptide binding]; other site
335659001931	Heme/copper-type cytochrome/quinol oxidases, subunit 1 [Energy production and conversion]; Region: CyoB; COG0843
335659001932	Ubiquinol oxidase subunit I.  Ubiquinol oxidase, the terminal oxidase in the respiratory chains of aerobic bacteria, is a multi-chain transmembrane protein located in the cell membrane.  It catalyzes the reduction of O2 and simultaneously pumps protons...; Region: Ubiquinol_Oxidase_I; cd01662
335659001933	D-pathway; other site
335659001934	Putative ubiquinol binding site [chemical binding]; other site
335659001935	Low-spin heme (heme b) binding site [chemical binding]; other site
335659001936	Putative water exit pathway; other site
335659001937	Binuclear center (heme o3/CuB) [ion binding]; other site
335659001938	K-pathway; other site
335659001939	Putative proton exit pathway; other site
335659001940	cytochrome o ubiquinol oxidase subunit II; Region: CyoA; TIGR01433
335659001941	Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; pfam00116
335659001942	COX Aromatic Rich Motif; Region: COX_ARM; pfam06481
335659001943	metabolite-proton symporter; Region: 2A0106; TIGR00883
335659001944	Putative Zn-dependent protease [General function prediction only]; Region: COG4784
335659001945	Peptidase family M48; Region: Peptidase_M48; cl12018
335659001946	Periplasmic binding protein; Region: Peripla_BP_6; pfam13458
335659001947	Periplasmic solute-binding domain of active transport proteins that belong to the type I periplasmic binding fold protein family; Region: PBP1_SBP_like_1; cd06327
335659001948	putative ligand binding site [chemical binding]; other site
335659001949	enoyl-CoA hydratase; Provisional; Region: PRK06688
335659001950	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
335659001951	substrate binding site [chemical binding]; other site
335659001952	oxyanion hole (OAH) forming residues; other site
335659001953	trimer interface [polypeptide binding]; other site
335659001954	This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632
335659001955	active site
335659001956	metal binding site [ion binding]; metal-binding site
335659001957	Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024
335659001958	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
335659001959	substrate binding site [chemical binding]; other site
335659001960	oxyanion hole (OAH) forming residues; other site
335659001961	trimer interface [polypeptide binding]; other site
335659001962	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
335659001963	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
335659001964	active site
335659001965	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
335659001966	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
335659001967	active site
335659001968	3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557
335659001969	classical (c) SDRs; Region: SDR_c; cd05233
335659001970	NAD(P) binding site [chemical binding]; other site
335659001971	active site
335659001972	Predicted membrane protein [Function unknown]; Region: COG2261
335659001973	Bacterial protein of unknown function (DUF937); Region: DUF937; cl01528
335659001974	2-dehydropantoate 2-reductase; Provisional; Region: PRK08229
335659001975	Ketopantoate reductase PanE/ApbA; Region: ApbA; pfam02558
335659001976	Ketopantoate reductase PanE/ApbA C terminal; Region: ApbA_C; pfam08546
335659001977	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
335659001978	long-chain-fatty-acid--CoA ligase; Validated; Region: PRK08276
335659001979	acyl-activating enzyme (AAE) consensus motif; other site
335659001980	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
335659001981	AMP binding site [chemical binding]; other site
335659001982	active site
335659001983	acyl-activating enzyme (AAE) consensus motif; other site
335659001984	CoA binding site [chemical binding]; other site
335659001985	hypothetical protein; Validated; Region: PRK06201
335659001986	Demethylmenaquinone methyltransferase [Coenzyme metabolism]; Region: MenG; COG0684
335659001987	Cupin domain; Region: Cupin_2; pfam07883
335659001988	Tripartite tricarboxylate transporter family receptor; Region: TctC; cl17792
335659001989	dihydroorotase; Provisional; Region: PRK09237
335659001990	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
335659001991	active site
335659001992	TlpA-like family; composed of  TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966
335659001993	Thioredoxin-like; Region: Thioredoxin_8; pfam13905
335659001994	catalytic residues [active]
335659001995	DsrE/DsrF-like family; Region: DrsE; cl00672
335659001996	DoxX-like family; Region: DoxX_2; pfam13564
335659001997	Transcriptional regulator [Transcription]; Region: LysR; COG0583
335659001998	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
335659001999	The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422
335659002000	putative effector binding pocket; other site
335659002001	dimerization interface [polypeptide binding]; other site
335659002002	methyl indole-3-acetate methyltransferase; Region: PLN02211; cl17657
335659002003	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
335659002004	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
335659002005	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
335659002006	Helix-turn-helix domain; Region: HTH_18; pfam12833
335659002007	choline dehydrogenase; Validated; Region: PRK02106
335659002008	GMC oxidoreductase; Region: GMC_oxred_C; pfam05199
335659002009	NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961
335659002010	Aldehyde dehydrogenase family; Region: Aldedh; pfam00171
335659002011	NAD(P) binding site [chemical binding]; other site
335659002012	catalytic residues [active]
335659002013	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
335659002014	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
335659002015	active site
335659002016	3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557
335659002017	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
335659002018	NAD(P) binding site [chemical binding]; other site
335659002019	active site
335659002020	SAV4209_like.  Similar in sequence to the Streptomyces avermitilis SAV4209 protein, with a hot dog fold that is similar to those of (R)-specific enoyl-CoA hydratase, the peroxisomal Hydratase-Dehydrogenase-Epimerase (HDE) protein, and the fatty acid...; Region: SAV4209_like; cd03453
335659002021	active site
335659002022	catalytic site [active]
335659002023	(R)-hydratase [(R)-specific enoyl-CoA hydratase]. Catalyzes the hydration of trans-2-enoyl CoA to (R)-3-hydroxyacyl-CoA as part of the PHA (polyhydroxyalkanoate) biosynthetic pathway.  The structure of the monomer includes a five-strand antiparallel...; Region: R_hydratase_like; cd03441
335659002024	active site
335659002025	catalytic site [active]
335659002026	lipid-transfer protein; Provisional; Region: PRK08256
335659002027	Thiolase domain associated with sterol carrier protein (SCP)-x isoform and related proteins; SCP-2  has multiple roles in intracellular lipid circulation and metabolism. The N-terminal presequence in the SCP-x isoform represents a peroxisomal...; Region: SCP-x_thiolase; cd00829
335659002028	active site
335659002029	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
335659002030	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
335659002031	long-chain-fatty-acid--CoA ligase; Validated; Region: PRK06187
335659002032	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
335659002033	Bacterial Bile acid CoA ligases and similar proteins; Region: BACL_like; cd05929
335659002034	acyl-activating enzyme (AAE) consensus motif; other site
335659002035	acyl-activating enzyme (AAE) consensus motif; other site
335659002036	putative AMP binding site [chemical binding]; other site
335659002037	putative active site [active]
335659002038	putative CoA binding site [chemical binding]; other site
335659002039	Predicted hydrolase of the alpha/beta-hydrolase fold [General function prediction only]; Region: COG3571
335659002040	2-dehydropantoate 2-reductase; Provisional; Region: PRK12921
335659002041	Ketopantoate reductase PanE/ApbA; Region: ApbA; pfam02558
335659002042	Ketopantoate reductase PanE/ApbA C terminal; Region: ApbA_C; pfam08546
335659002043	enoyl-CoA hydratase; Provisional; Region: PRK05995
335659002044	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
335659002045	substrate binding site [chemical binding]; other site
335659002046	oxyanion hole (OAH) forming residues; other site
335659002047	trimer interface [polypeptide binding]; other site
335659002048	FAD dependent oxidoreductase; Region: FAD_oxidored; pfam12831
335659002049	ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components [Inorganic ion transport and metabolism]; Region: TauA; COG0715
335659002050	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cl17432
335659002051	substrate binding pocket [chemical binding]; other site
335659002052	membrane-bound complex binding site; other site
335659002053	hinge residues; other site
335659002054	ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116
335659002055	ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293
335659002056	Walker A/P-loop; other site
335659002057	ATP binding site [chemical binding]; other site
335659002058	Q-loop/lid; other site
335659002059	ABC transporter signature motif; other site
335659002060	Walker B; other site
335659002061	D-loop; other site
335659002062	H-loop/switch region; other site
335659002063	ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600
335659002064	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427
335659002065	gentisate 1,2-dioxygenase; Region: gentisate_1_2; TIGR02272
335659002066	Cupin domain; Region: Cupin_2; pfam07883
335659002067	GST_N family, Class Zeta subfamily; GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of endogenous and xenobiotic alkylating agents, including carcinogens; Region: GST_N_Zeta; cd03042
335659002068	maleylacetoacetate isomerase; Region: maiA; TIGR01262
335659002069	C-terminal domain interface [polypeptide binding]; other site
335659002070	GSH binding site (G-site) [chemical binding]; other site
335659002071	putative dimer interface [polypeptide binding]; other site
335659002072	C-terminal, alpha helical domain of Class Zeta Glutathione S-transferases; Region: GST_C_Zeta; cd03191
335659002073	dimer interface [polypeptide binding]; other site
335659002074	N-terminal domain interface [polypeptide binding]; other site
335659002075	maleylacetoacetate (MAA) substrate binding site (H site) [chemical binding]; other site
335659002076	helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347
335659002077	MarR family; Region: MarR_2; pfam12802
335659002078	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
335659002079	benzoate-CoA ligase family; Region: benz_CoA_lig; TIGR02262
335659002080	acyl-activating enzyme (AAE) consensus motif; other site
335659002081	AMP binding site [chemical binding]; other site
335659002082	active site
335659002083	CoA binding site [chemical binding]; other site
335659002084	ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314
335659002085	ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314
335659002086	Cysteine rich repeat; Region: Cys_rich_FGFR; pfam00839
335659002087	Cysteine rich repeat; Region: Cys_rich_FGFR; pfam00839
335659002088	Putative NADP-dependent oxidoreductases [General function prediction only]; Region: COG2130
335659002089	Prostaglandin dehydrogenases; Region: PGDH; cd05288
335659002090	NAD(P) binding site [chemical binding]; other site
335659002091	substrate binding site [chemical binding]; other site
335659002092	dimer interface [polypeptide binding]; other site
335659002093	Sodium:dicarboxylate symporter family; Region: SDF; cl00573
335659002094	Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301
335659002095	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
335659002096	Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497
335659002097	substrate binding pocket [chemical binding]; other site
335659002098	membrane-bound complex binding site; other site
335659002099	hinge residues; other site
335659002100	ATP-grasp domain; Region: ATP-grasp_4; cl17255
335659002101	Flavodoxin reductases (ferredoxin-NADPH reductases) family 1 [Energy production and conversion]; Region: Hmp; COG1018
335659002102	Ferredoxin-NADP+ (oxido)reductase is an FAD-containing enzyme that catalyzes the reversible electron transfer between NADP(H) and electron carrier proteins such as ferredoxin and flavodoxin. Isoforms of these flavoproteins (i.e. having a non-covalently...; Region: FNR1; cd06195
335659002103	FAD binding pocket [chemical binding]; other site
335659002104	FAD binding motif [chemical binding]; other site
335659002105	phosphate binding motif [ion binding]; other site
335659002106	beta-alpha-beta structure motif; other site
335659002107	NAD binding pocket [chemical binding]; other site
335659002108	Glutamate synthase domain 2 [Amino acid transport and metabolism]; Region: GltB; COG0069
335659002109	Glutamate synthase (GltS) FMN-binding domain.  GltS is a complex iron-sulfur flavoprotein that catalyzes the reductive synthesis of L-glutamate from 2-oxoglutarate and L-glutamine via intramolecular channelling of ammonia, a reaction in the plant, yeast...; Region: GltS_FMN; cd02808
335659002110	active site
335659002111	FMN binding site [chemical binding]; other site
335659002112	substrate binding site [chemical binding]; other site
335659002113	3Fe-4S cluster binding site [ion binding]; other site
335659002114	PilZ domain; Region: PilZ; pfam07238
335659002115	Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253
335659002116	Domain of unknown function DUF21; Region: DUF21; pfam01595
335659002117	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590
335659002118	Transporter associated domain; Region: CorC_HlyC; smart01091
335659002119	Flp pilus assembly protein TadG [Intracellular trafficking and secretion]; Region: TadG; COG4961
335659002120	Opacity protein and related surface antigens [Cell envelope biogenesis, outer membrane]; Region: COG3637
335659002121	Carbohydrate-selective porin, OprB family; Region: OprB; pfam04966
335659002122	Creatinine amidohydrolase; Region: Creatininase; pfam02633
335659002123	ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components [Inorganic ion transport and metabolism]; Region: TauA; COG0715
335659002124	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cl17432
335659002125	ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116
335659002126	ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293
335659002127	Walker A/P-loop; other site
335659002128	ATP binding site [chemical binding]; other site
335659002129	Q-loop/lid; other site
335659002130	ABC transporter signature motif; other site
335659002131	Walker B; other site
335659002132	D-loop; other site
335659002133	H-loop/switch region; other site
335659002134	ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600
335659002135	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427
335659002136	Lactate dehydrogenase and related dehydrogenases [Energy production and conversion / Coenzyme metabolism / General function prediction only]; Region: LdhA; COG1052
335659002137	Hydroxy(phenyl)pyruvate Reductase, D-isomer-specific 2-hydroxyacid-related dehydrogenase; Region: HPPR; cd12156
335659002138	putative ligand binding site [chemical binding]; other site
335659002139	NAD binding site [chemical binding]; other site
335659002140	catalytic site [active]
335659002141	Lysozyme family protein [General function prediction only]; Region: COG5526
335659002142	Putative peptidoglycan-binding domain-containing protein [Cell envelope biogenesis, outer membrane]; Region: COG3409
335659002143	Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471
335659002144	hypothetical protein; Reviewed; Region: PRK00024
335659002145	Mov34/MPN/PAD-1 family; Region: MPN_DUF2466; cd08071
335659002146	MPN+ (JAMM) motif; other site
335659002147	Zinc-binding site [ion binding]; other site
335659002148	methionine aminopeptidase; Provisional; Region: PRK12318
335659002149	Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086
335659002150	active site
335659002151	Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668
335659002152	Mechanosensitive ion channel; Region: MS_channel; pfam00924
335659002153	potassium/proton antiporter; Reviewed; Region: PRK05326
335659002154	Transporter associated domain; Region: CorC_HlyC; smart01091
335659002155	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
335659002156	putative bacteriocin export ABC transporter, lactococcin 972 group; Region: L_ocin_972_ABC; TIGR03608
335659002157	Walker A/P-loop; other site
335659002158	ATP binding site [chemical binding]; other site
335659002159	Q-loop/lid; other site
335659002160	ABC transporter signature motif; other site
335659002161	Walker B; other site
335659002162	D-loop; other site
335659002163	H-loop/switch region; other site
335659002164	ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555
335659002165	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
335659002166	dimer interface [polypeptide binding]; other site
335659002167	conserved gate region; other site
335659002168	putative PBP binding loops; other site
335659002169	ABC-ATPase subunit interface; other site
335659002170	Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531
335659002171	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199
335659002172	penicillin-insensitive murein endopeptidase; Reviewed; Region: mepA; PRK09429
335659002173	PAS fold; Region: PAS_7; pfam12860
335659002174	PAS domain S-box; Region: sensory_box; TIGR00229
335659002175	PAS domain; Region: PAS_8; pfam13188
335659002176	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
335659002177	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
335659002178	metal binding site [ion binding]; metal-binding site
335659002179	active site
335659002180	I-site; other site
335659002181	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
335659002182	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
335659002183	dimerization interface [polypeptide binding]; other site
335659002184	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
335659002185	dimer interface [polypeptide binding]; other site
335659002186	Methyl-accepting chemotaxis protein (MCP) signalling domain; Region: MCPsignal; pfam00015
335659002187	putative CheW interface [polypeptide binding]; other site
335659002188	Membrane Fusion Protein cluster 2 (function with RND porters); Region: 8a0102; TIGR00999
335659002189	HlyD family secretion protein; Region: HlyD_3; pfam13437
335659002190	Putative silver efflux pump [Inorganic ion transport and metabolism]; Region: COG3696
335659002191	Protein of unknown function (DUF3240); Region: DUF3240; pfam11582
335659002192	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
335659002193	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
335659002194	DNA binding site [nucleotide binding]
335659002195	Predicted integral membrane protein [Function unknown]; Region: COG5616
335659002196	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
335659002197	TPR motif; other site
335659002198	binding surface
335659002199	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
335659002200	binding surface
335659002201	TPR motif; other site
335659002202	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
335659002203	NADH(P)-binding; Region: NAD_binding_10; pfam13460
335659002204	NAD(P) binding site [chemical binding]; other site
335659002205	active site
335659002206	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
335659002207	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
335659002208	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
335659002209	Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596
335659002210	Putative lysophospholipase; Region: Hydrolase_4; pfam12146
335659002211	NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252
335659002212	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
335659002213	Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849
335659002214	Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583
335659002215	oxalate/formate antiporter family transporter; Region: 2A0111; TIGR00890
335659002216	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
335659002217	putative substrate translocation pore; other site
335659002218	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
335659002219	Acetyltransferases [General function prediction only]; Region: RimI; COG0456
335659002220	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
335659002221	Coenzyme A binding pocket [chemical binding]; other site
335659002222	Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680
335659002223	Beta-lactamase; Region: Beta-lactamase; pfam00144
335659002224	Putative hydrophobic ligand-binding SRPBCC domain of an uncharacterized subgroup of CalC- and Aha1-like proteins; Region: SRPBCC_CalC_Aha1-like_4; cd08897
335659002225	putative hydrophobic ligand binding site [chemical binding]; other site
335659002226	GTP-binding protein LepA; Provisional; Region: PRK05433
335659002227	LepA also known as Elongation Factor 4 (EF4); Region: LepA; cd01890
335659002228	G1 box; other site
335659002229	putative GEF interaction site [polypeptide binding]; other site
335659002230	GTP/Mg2+ binding site [chemical binding]; other site
335659002231	Switch I region; other site
335659002232	G2 box; other site
335659002233	G3 box; other site
335659002234	Switch II region; other site
335659002235	G4 box; other site
335659002236	G5 box; other site
335659002237	Translation_Factor_II_like: Elongation factor Tu (EF-Tu) domain II-like proteins. Elongation factor Tu consists of three structural domains, this family represents the second domain. Domain II adopts a beta barrel structure and is involved in binding to...; Region: Translation_Factor_II_like; cl02787
335659002238	lepA_C: This family represents the C-terminal region of LepA, a GTP-binding protein localized in the cytoplasmic membrane.   LepA is ubiquitous in Bacteria and Eukaryota (e.g. Saccharomyces cerevisiae GUF1p), but is missing from Archaea. LepA exhibits...; Region: lepA_C; cd03709
335659002239	GTP-binding protein LepA C-terminus; Region: LepA_C; pfam06421
335659002240	Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; pfam13231
335659002241	Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367
335659002242	regulatory protein interface [polypeptide binding]; other site
335659002243	active site
335659002244	regulatory phosphorylation site [posttranslational modification]; other site
335659002245	PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cd00006
335659002246	active pocket/dimerization site; other site
335659002247	active site
335659002248	phosphorylation site [posttranslational modification]
335659002249	HprK/P, the bifunctional histidine-containing protein kinase/phosphatase, controls the phosphorylation state of the phosphocarrier protein HPr and regulates the utilization of carbon sources by gram-positive bacteria. It catalyzes both the ATP-dependent...; Region: HprK_C; cd01918
335659002250	Hpr binding site; other site
335659002251	active site
335659002252	homohexamer subunit interaction site [polypeptide binding]; other site
335659002253	Sensor N-terminal transmembrane domain; Region: Sensor_TM1; pfam13755
335659002254	Stimulus-sensing domain; Region: Stimulus_sens_1; pfam13756
335659002255	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
335659002256	HAMP domain; Region: HAMP; pfam00672
335659002257	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
335659002258	dimer interface [polypeptide binding]; other site
335659002259	phosphorylation site [posttranslational modification]
335659002260	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
335659002261	ATP binding site [chemical binding]; other site
335659002262	Mg2+ binding site [ion binding]; other site
335659002263	G-X-G motif; other site
335659002264	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
335659002265	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
335659002266	active site
335659002267	phosphorylation site [posttranslational modification]
335659002268	intermolecular recognition site; other site
335659002269	dimerization interface [polypeptide binding]; other site
335659002270	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
335659002271	DNA binding site [nucleotide binding]
335659002272	Pyridoxamine 5'-phosphate oxidase; Region: Pyrid_oxidase_2; pfam13883
335659002273	Putative heme iron utilization protein [Inorganic ion transport and metabolism]; Region: HugZ; COG0748
335659002274	Protein of unknown function (DUF2470); Region: DUF2470; pfam10615
335659002275	Tetratricopeptide repeat; Region: TPR_12; pfam13424
335659002276	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
335659002277	binding surface
335659002278	TPR motif; other site
335659002279	Tetratricopeptide repeat; Region: TPR_12; pfam13424
335659002280	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
335659002281	binding surface
335659002282	TPR motif; other site
335659002283	Tetratricopeptide repeat; Region: TPR_12; pfam13424
335659002284	Tetratricopeptide repeat; Region: TPR_12; pfam13424
335659002285	CHAT domain; Region: CHAT; pfam12770
335659002286	Phosphoenolpyruvate carboxykinase; Region: PEPCK_ATP; pfam01293
335659002287	Phosphoenolpyruvate carboxykinase (PEPCK), a critical gluconeogenic enzyme, catalyzes the first committed step in the diversion of tricarboxylic acid cycle intermediates toward gluconeogenesis. It catalyzes the reversible decarboxylation and...; Region: PEPCK_ATP; cd00484
335659002288	active site
335659002289	substrate-binding site [chemical binding]; other site
335659002290	metal-binding site [ion binding]
335659002291	ATP binding site [chemical binding]; other site
335659002292	Thioesterase-like superfamily; Region: 4HBT_3; pfam13622
335659002293	The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cd03440
335659002294	active site 2 [active]
335659002295	active site 1 [active]
335659002296	This is a family of oligosaccharide phosphorylases. It includes yeast and mammalian glycogen phosphorylases, plant starch/glucan phosphorylase, as well as the maltodextrin phosphorylases of bacteria. The members of this family catalyze the breakdown of...; Region: GT1_Glycogen_Phosphorylase; cd04300
335659002297	glycogen/starch/alpha-glucan phosphorylases; Region: P_ylase; TIGR02093
335659002298	homodimer interface [polypeptide binding]; other site
335659002299	active site pocket [active]
335659002300	PAN domain; Region: PAN_4; pfam14295
335659002301	Subfamily of PAN/APPLE-like domains; present in plasma prekallikrein/coagulation factor XI, microneme antigen proteins, and a few prokaryotic proteins. PAN/APPLE domains fulfill diverse biological functions by mediating protein-protein or...; Region: APPLE_Factor_XI_like; cd01100
335659002302	putative binding site; other site
335659002303	glutamate--cysteine ligase; Region: PLN02611
335659002304	MarR family; Region: MarR_2; pfam12802
335659002305	Transcriptional regulators [Transcription]; Region: MarR; COG1846
335659002306	glutathionine S-transferase; Provisional; Region: PRK10542
335659002307	GST_N family, Class Beta subfamily; GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of endogenous and xenobiotic alkylating agents, including carcinogens; Region: GST_N_Beta; cd03057
335659002308	C-terminal domain interface [polypeptide binding]; other site
335659002309	GSH binding site (G-site) [chemical binding]; other site
335659002310	dimer interface [polypeptide binding]; other site
335659002311	C-terminal, alpha helical domain of Class Beta Glutathione S-transferases; Region: GST_C_Beta; cd03188
335659002312	N-terminal domain interface [polypeptide binding]; other site
335659002313	dimer interface [polypeptide binding]; other site
335659002314	substrate binding pocket (H-site) [chemical binding]; other site
335659002315	multifunctional fatty acid oxidation complex subunit alpha; Reviewed; Region: fadJ; PRK11154
335659002316	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
335659002317	substrate binding site [chemical binding]; other site
335659002318	oxyanion hole (OAH) forming residues; other site
335659002319	trimer interface [polypeptide binding]; other site
335659002320	3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737
335659002321	3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725
335659002322	acetyl-CoA acetyltransferase; Validated; Region: PRK08242
335659002323	Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751
335659002324	dimer interface [polypeptide binding]; other site
335659002325	active site
335659002326	acyl-CoA dehydrogenase; Provisional; Region: PTZ00456
335659002327	Acyl-CoA dehydrogenase N terminal; Region: AcylCoA_DH_N; pfam12418
335659002328	Putative acyl-CoA dehydrogenases similar to fadE5; Region: ACAD_fadE5; cd01153
335659002329	FAD binding site [chemical binding]; other site
335659002330	substrate binding site [chemical binding]; other site
335659002331	catalytic residues [active]
335659002332	Acetyl-CoA dehydrogenase C-terminal like; Region: Acyl-CoA_dh_C; pfam12806
335659002333	SnoaL-like domain; Region: SnoaL_2; pfam12680
335659002334	Predicted transcriptional regulators [Transcription]; Region: COG1695
335659002335	Transcriptional regulator PadR-like family; Region: PadR; pfam03551
335659002336	Virulence activator alpha C-term; Region: Vir_act_alpha_C; pfam10400
335659002337	Protein of unknown function (DUF2934); Region: DUF2934; pfam11154
335659002338	FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790
335659002339	Sel1-like repeats; Region: SEL1; smart00671
335659002340	Sel1-like repeats; Region: SEL1; smart00671
335659002341	Sel1 repeat; Region: Sel1; pfam08238
335659002342	Sel1-like repeats; Region: SEL1; smart00671
335659002343	Sulfite exporter TauE/SafE; Region: TauE; pfam01925
335659002344	Putative transmembrane protein (Alph_Pro_TM); Region: Alph_Pro_TM; cl09826
335659002345	Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220
335659002346	Beta-lactamase superfamily domain; Region: Lactamase_B_2; pfam12706
335659002347	putative DMT superfamily transporter inner membrane protein; Provisional; Region: PRK11272
335659002348	EamA-like transporter family; Region: EamA; pfam00892
335659002349	EamA-like transporter family; Region: EamA; pfam00892
335659002350	Transcriptional regulator [Transcription]; Region: LysR; COG0583
335659002351	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
335659002352	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
335659002353	dimerization interface [polypeptide binding]; other site
335659002354	signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227
335659002355	The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530
335659002356	Catalytic site [active]
335659002357	The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530
335659002358	protease TldD; Provisional; Region: tldD; PRK10735
335659002359	Invasion associated locus B (IalB) protein; Region: IalB; cl02207
335659002360	Cytochrome C oxidase subunit II, transmembrane domain; Region: COX2_TM; pfam02790
335659002361	cytochrome c oxidase subunit II; Provisional; Region: COX2; MTH00154
335659002362	Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; pfam00116
335659002363	Heme/copper-type cytochrome/quinol oxidases, subunit 1 [Energy production and conversion]; Region: CyoB; COG0843
335659002364	Cytochrome C oxidase subunit I.  Cytochrome c oxidase (CcO), the terminal oxidase in the respiratory chains of eukaryotes and most bacteria, is a multi-chain transmembrane protein located in the inner membrane of mitochondria and the cell membrane of...; Region: Cyt_c_Oxidase_I; cd01663
335659002365	Subunit I/III interface [polypeptide binding]; other site
335659002366	D-pathway; other site
335659002367	Subunit I/VIIc interface [polypeptide binding]; other site
335659002368	Subunit I/IV interface [polypeptide binding]; other site
335659002369	Subunit I/II interface [polypeptide binding]; other site
335659002370	Low-spin heme (heme a) binding site [chemical binding]; other site
335659002371	Subunit I/VIIa interface [polypeptide binding]; other site
335659002372	Subunit I/VIa interface [polypeptide binding]; other site
335659002373	Dimer interface; other site
335659002374	Putative water exit pathway; other site
335659002375	Binuclear center (heme a3/CuB) [ion binding]; other site
335659002376	K-pathway; other site
335659002377	Subunit I/Vb interface [polypeptide binding]; other site
335659002378	Putative proton exit pathway; other site
335659002379	Subunit I/VIb interface; other site
335659002380	Subunit I/VIc interface [polypeptide binding]; other site
335659002381	Electron transfer pathway; other site
335659002382	Subunit I/VIIIb interface [polypeptide binding]; other site
335659002383	Subunit I/VIIb interface [polypeptide binding]; other site
335659002384	protoheme IX farnesyltransferase; Provisional; Region: PRK04375
335659002385	UbiA prenyltransferase family; Region: UbiA; pfam01040
335659002386	cytochrome C oxidase assembly protein; Provisional; Region: PRK05089
335659002387	Cytochrome c oxidase subunit III.  Cytochrome c oxidase (CcO), the terminal oxidase in the respiratory chains of eukaryotes and most bacteria, is a multi-chain transmembrane protein located in the inner membrane of mitochondria and the cell membrane of...; Region: Cyt_c_Oxidase_III; cd01665
335659002388	Subunit III/VIIa interface [polypeptide binding]; other site
335659002389	Phospholipid binding site [chemical binding]; other site
335659002390	Subunit I/III interface [polypeptide binding]; other site
335659002391	Subunit III/VIb interface [polypeptide binding]; other site
335659002392	Subunit III/VIa interface; other site
335659002393	Subunit III/Vb interface [polypeptide binding]; other site
335659002394	Protein of unknown function (DUF983); Region: DUF983; cl02211
335659002395	SURF1 superfamily. Surf1/Shy1 has been implicated in the posttranslational steps of the biogenesis of the mitochondrially-encoded Cox1 subunit of cytochrome c oxidase (complex IV). Cytochrome c oxidase (complex IV), the terminal electron-transferring...; Region: SURF1; cd06662
335659002396	SnoaL-like domain; Region: SnoaL_2; pfam12680
335659002397	HAMP domain; Region: HAMP; pfam00672
335659002398	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585
335659002399	Histidine kinase; Region: HisKA_3; pfam07730
335659002400	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
335659002401	Mg2+ binding site [ion binding]; other site
335659002402	G-X-G motif; other site
335659002403	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
335659002404	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
335659002405	active site
335659002406	phosphorylation site [posttranslational modification]
335659002407	intermolecular recognition site; other site
335659002408	dimerization interface [polypeptide binding]; other site
335659002409	DNA-binding HTH domain-containing proteins [Transcription]; Region: CsgD; COG2771
335659002410	DNA binding residues [nucleotide binding]
335659002411	dimerization interface [polypeptide binding]; other site
335659002412	Threonine synthase [Amino acid transport and metabolism]; Region: ThrC; COG0498
335659002413	Threonine synthase catalyzes the final step of threonine biosynthesis. The conversion of O-phosphohomoserine into threonine and inorganic phosphate is pyridoxal 5'-phosphate dependent. The Thr-synth_1 CD includes members from higher plants; Region: Thr-synth_2; cd01560
335659002414	pyridoxal 5'-phosphate binding site [chemical binding]; other site
335659002415	catalytic residue [active]
335659002416	Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612
335659002417	Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675
335659002418	Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193
335659002419	Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670
335659002420	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182
335659002421	F0F1 ATP synthase subunit B; Validated; Region: PRK09173
335659002422	F0F1 ATP synthase subunit B; Provisional; Region: PRK14475
335659002423	ATP synthase B/B' CF(0); Region: ATP-synt_B; cl17192
335659002424	F0F1 ATP synthase subunit B'; Validated; Region: PRK07353
335659002425	F0F1 ATP synthase subunit C; Validated; Region: PRK07558
335659002426	F0F1-type ATP synthase, subunit a [Energy production and conversion]; Region: AtpB; COG0356
335659002427	ATP synthase subunit 6 (eukaryotes),also subunit A (prokaryotes); Region: ATP_synt_6_or_A; TIGR01131
335659002428	Uncharacterized protein family UPF0047; Region: UPF0047; pfam01894
335659002429	metabolite-proton symporter; Region: 2A0106; TIGR00883
335659002430	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
335659002431	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
335659002432	active site
335659002433	phosphorylation site [posttranslational modification]
335659002434	intermolecular recognition site; other site
335659002435	dimerization interface [polypeptide binding]; other site
335659002436	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
335659002437	DNA binding residues [nucleotide binding]
335659002438	dimerization interface [polypeptide binding]; other site
335659002439	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
335659002440	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
335659002441	DNA binding site [nucleotide binding]
335659002442	Predicted ATPase [General function prediction only]; Region: COG3903
335659002443	Tetratricopeptide repeat; Region: TPR_12; pfam13424
335659002444	peroxiredoxin, Ohr subfamily; Region: organ_hyd_perox; TIGR03561
335659002445	Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596
335659002446	short chain dehydrogenase; Provisional; Region: PRK08263
335659002447	17beta hydroxysteroid dehydrogenase-like, classical (c) SDRs; Region: 17beta-HSD-like_SDR_c; cd05374
335659002448	NADP binding site [chemical binding]; other site
335659002449	active site
335659002450	steroid binding site; other site
335659002451	Na+/proline symporter [Amino acid transport and metabolism / General function prediction only]; Region: PutP; COG0591
335659002452	Na binding site [ion binding]; other site
335659002453	PAS fold; Region: PAS_7; pfam12860
335659002454	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
335659002455	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
335659002456	dimer interface [polypeptide binding]; other site
335659002457	phosphorylation site [posttranslational modification]
335659002458	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
335659002459	ATP binding site [chemical binding]; other site
335659002460	Mg2+ binding site [ion binding]; other site
335659002461	G-X-G motif; other site
335659002462	FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784
335659002463	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
335659002464	active site
335659002465	phosphorylation site [posttranslational modification]
335659002466	intermolecular recognition site; other site
335659002467	dimerization interface [polypeptide binding]; other site
335659002468	pyridoxal phosphate-dependent acyltransferase, putative; Region: gly_Cac_T_rel; TIGR01825
335659002469	KBL_like; this family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to serine palmitoyltransferase (SPT), 5-aminolevulinate synthase (ALAS); Region: KBL_like; cd06454
335659002470	substrate-cofactor binding pocket; other site
335659002471	pyridoxal 5'-phosphate binding site [chemical binding]; other site
335659002472	catalytic residue [active]
335659002473	Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491
335659002474	Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283
335659002475	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
335659002476	dimer interface [polypeptide binding]; other site
335659002477	putative CheW interface [polypeptide binding]; other site
335659002478	Opacity protein and related surface antigens [Cell envelope biogenesis, outer membrane]; Region: COG3637
335659002479	PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria.  Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443
335659002480	CoenzymeA binding site [chemical binding]; other site
335659002481	subunit interaction site [polypeptide binding]; other site
335659002482	PHB binding site; other site
335659002483	ATPase components of various ABC-type transport systems, contain duplicated ATPase [General function prediction only]; Region: COG1123
335659002484	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
335659002485	Walker A/P-loop; other site
335659002486	ATP binding site [chemical binding]; other site
335659002487	Q-loop/lid; other site
335659002488	ABC transporter signature motif; other site
335659002489	Walker B; other site
335659002490	D-loop; other site
335659002491	H-loop/switch region; other site
335659002492	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; pfam08352
335659002493	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
335659002494	Walker A/P-loop; other site
335659002495	ATP binding site [chemical binding]; other site
335659002496	Q-loop/lid; other site
335659002497	ABC transporter signature motif; other site
335659002498	Walker B; other site
335659002499	D-loop; other site
335659002500	H-loop/switch region; other site
335659002501	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097
335659002502	nickel ABC transporter, permease subunit NikC; Region: nickel_nikC; TIGR02790
335659002503	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
335659002504	dimer interface [polypeptide binding]; other site
335659002505	conserved gate region; other site
335659002506	putative PBP binding loops; other site
335659002507	ABC-ATPase subunit interface; other site
335659002508	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601
335659002509	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
335659002510	dimer interface [polypeptide binding]; other site
335659002511	conserved gate region; other site
335659002512	putative PBP binding loops; other site
335659002513	ABC-ATPase subunit interface; other site
335659002514	The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_13; cd08517
335659002515	Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496
335659002516	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
335659002517	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
335659002518	Uncharacterized protein conserved in bacteria (DUF2147); Region: DUF2147; pfam09917
335659002519	Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153
335659002520	metal binding site 2 [ion binding]; metal-binding site
335659002521	putative DNA binding helix; other site
335659002522	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
335659002523	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
335659002524	DNA binding site [nucleotide binding]
335659002525	Predicted integral membrane protein [Function unknown]; Region: COG5616
335659002526	TPR repeat; Region: TPR_11; pfam13414
335659002527	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
335659002528	TPR motif; other site
335659002529	binding surface
335659002530	Putative protein-S-isoprenylcysteine methyltransferase [Posttranslational modification, protein turnover, chaperones]; Region: STE14; COG2020
335659002531	Uncharacterized conserved protein [Function unknown]; Region: COG3791
335659002532	DNA-binding winged-HTH domains [Transcription]; Region: CadC; COG3710
335659002533	DNA binding site [nucleotide binding]
335659002534	Predicted integral membrane protein [Function unknown]; Region: COG5616
335659002535	TPR repeat; Region: TPR_11; pfam13414
335659002536	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
335659002537	binding surface
335659002538	TPR motif; other site
335659002539	prokaryotic 3-carboxy-cis,cis-muconate cycloisomerase (CMLE)_like; Region: pCLME; cd01597
335659002540	Adenylosuccinate lyase [Nucleotide transport and metabolism]; Region: PurB; COG0015
335659002541	tetramer interface [polypeptide binding]; other site
335659002542	active site
335659002543	Leucyl aminopeptidase (aminopeptidase T) [Amino acid transport and metabolism]; Region: AmpS; COG2309
335659002544	Thermophilic metalloprotease (M29); Region: Peptidase_M29; pfam02073
335659002545	Protein of unknown function (DUF861); Region: Cupin_3; cl17594
335659002546	Predicted metal-dependent hydrolase of the TIM-barrel fold [General function prediction only]; Region: COG3618
335659002547	Amidohydrolase; Region: Amidohydro_2; pfam04909
335659002548	Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220
335659002549	Beta-lactamase superfamily domain; Region: Lactamase_B_3; pfam13483
335659002550	ABC-type Na+ transport system, ATPase component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatA; COG4555
335659002551	ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230
335659002552	Walker A/P-loop; other site
335659002553	ATP binding site [chemical binding]; other site
335659002554	Q-loop/lid; other site
335659002555	ABC transporter signature motif; other site
335659002556	Walker B; other site
335659002557	D-loop; other site
335659002558	H-loop/switch region; other site
335659002559	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
335659002560	Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582
335659002561	TM-ABC transporter signature motif; other site
335659002562	ABC-type branched-chain amino acid transport system, permease component [Amino acid transport and metabolism]; Region: LivM; COG4177
335659002563	Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581
335659002564	TM-ABC transporter signature motif; other site
335659002565	ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411
335659002566	ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219
335659002567	Walker A/P-loop; other site
335659002568	ATP binding site [chemical binding]; other site
335659002569	Q-loop/lid; other site
335659002570	ABC transporter signature motif; other site
335659002571	Walker B; other site
335659002572	D-loop; other site
335659002573	H-loop/switch region; other site
335659002574	ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410
335659002575	ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224
335659002576	Walker A/P-loop; other site
335659002577	ATP binding site [chemical binding]; other site
335659002578	Q-loop/lid; other site
335659002579	ABC transporter signature motif; other site
335659002580	Walker B; other site
335659002581	D-loop; other site
335659002582	H-loop/switch region; other site
335659002583	Long-chain acyl-CoA synthetases (AMP-forming) [Lipid metabolism]; Region: FAA1; COG1022
335659002584	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
335659002585	Long-chain fatty acid CoA synthetases and Bubblegum-like very long-chain fatty acid CoA synthetases; Region: VL_LC_FACS_like; cd05907
335659002586	acyl-activating enzyme (AAE) consensus motif; other site
335659002587	putative AMP binding site [chemical binding]; other site
335659002588	putative active site [active]
335659002589	putative CoA binding site [chemical binding]; other site
335659002590	Type I periplasmic ligand-binding domain of uncharacterized ABC (ATPase Binding Cassette)-type active transport systems that are predicted to be involved in uptake of amino acids, peptides, or inorganic ions; Region: PBP1_ABC_ligand_binding_like_8; cd06343
335659002591	Periplasmic binding protein; Region: Peripla_BP_6; pfam13458
335659002592	putative ligand binding site [chemical binding]; other site
335659002593	Protein of unknown function (DUF1311); Region: DUF1311; pfam07007
335659002594	Protein of unknown function (DUF1311); Region: DUF1311; pfam07007
335659002595	Bacterial transglutaminase-like cysteine proteinase BTLCP; Region: BTLCP; cl17596
335659002596	Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305
335659002597	hypothetical protein; Provisional; Region: PRK09945
335659002598	VCBS repeat; Region: VCBS_repeat; TIGR01965
335659002599	Predicted transmembrane sensor domain [Signal transduction mechanisms]; Region: COG4252
335659002600	CHASE2 is an extracellular sensory domain, which is present in various classes of transmembrane receptors that are parts of signal transduction pathways in bacteria; Region: CHASE2; smart01080
335659002601	Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114
335659002602	cyclase homology domain; Region: CHD; cd07302
335659002603	nucleotidyl binding site; other site
335659002604	metal binding site [ion binding]; metal-binding site
335659002605	dimer interface [polypeptide binding]; other site
335659002606	The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_8; cd08495
335659002607	Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496
335659002608	ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747
335659002609	The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_8; cd08495
335659002610	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601
335659002611	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
335659002612	dimer interface [polypeptide binding]; other site
335659002613	conserved gate region; other site
335659002614	putative PBP binding loops; other site
335659002615	ABC-ATPase subunit interface; other site
335659002616	nickel ABC transporter, permease subunit NikC; Region: nickel_nikC; TIGR02790
335659002617	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
335659002618	dimer interface [polypeptide binding]; other site
335659002619	conserved gate region; other site
335659002620	putative PBP binding loops; other site
335659002621	ABC-ATPase subunit interface; other site
335659002622	ABC-type oligopeptide transport system, ATPase component [Amino acid transport and metabolism]; Region: AppF; COG4608
335659002623	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
335659002624	Walker A/P-loop; other site
335659002625	ATP binding site [chemical binding]; other site
335659002626	Q-loop/lid; other site
335659002627	ABC transporter signature motif; other site
335659002628	Walker B; other site
335659002629	D-loop; other site
335659002630	H-loop/switch region; other site
335659002631	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097
335659002632	Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154
335659002633	Amidase; Region: Amidase; pfam01425
335659002634	ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444
335659002635	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
335659002636	Walker A/P-loop; other site
335659002637	ATP binding site [chemical binding]; other site
335659002638	Q-loop/lid; other site
335659002639	ABC transporter signature motif; other site
335659002640	Walker B; other site
335659002641	D-loop; other site
335659002642	H-loop/switch region; other site
335659002643	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097
335659002644	Predicted membrane protein [Function unknown]; Region: COG2261
335659002645	ABC-type protease/lipase transport system, ATPase and permease components [General function prediction only]; Region: ArpD; COG4618
335659002646	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
335659002647	ATP-binding cassette domain of PrtD, subfamily C; Region: ABCC_Protease_Secretion; cd03246
335659002648	Walker A/P-loop; other site
335659002649	ATP binding site [chemical binding]; other site
335659002650	Q-loop/lid; other site
335659002651	ABC transporter signature motif; other site
335659002652	Walker B; other site
335659002653	D-loop; other site
335659002654	H-loop/switch region; other site
335659002655	type I secretion membrane fusion protein, HlyD family; Region: type_I_hlyD; TIGR01843
335659002656	HlyD family secretion protein; Region: HlyD_3; pfam13437
335659002657	AMP nucleosidase; Provisional; Region: PRK08292
335659002658	Bacterial AMP nucleoside phosphorylase N-terminus; Region: AMNp_N; pfam10423
335659002659	Nucleoside phosphorylase [Nucleotide transport and metabolism]; Region: Pfs; COG0775
335659002660	Protein of unknown function (DUF1488); Region: DUF1488; pfam07369
335659002661	Competence-damaged protein; Region: CinA; pfam02464
335659002662	Amidohydrolase; Region: Amidohydro_2; pfam04909
335659002663	Amidohydrolase; Region: Amidohydro_2; pfam04909
335659002664	Ferredoxin subunits of nitrite reductase and ring-hydroxylating dioxygenases [Inorganic ion transport and metabolism / General function prediction only]; Region: {NirD}; COG2146
335659002665	iron-sulfur cluster [ion binding]; other site
335659002666	[2Fe-2S] cluster binding site [ion binding]; other site
335659002667	citrate-proton symporter; Provisional; Region: PRK15075
335659002668	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
335659002669	putative substrate translocation pore; other site
335659002670	DNA-binding transcriptional activator GcvA; Provisional; Region: PRK11139
335659002671	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
335659002672	The C-terminal substrate domain of LysR-type GcdR, TrPI, HvR and beta-lactamase regulators, and that of other closely related homologs; contains the type 2 periplasmic binding fold; Region: PBP2_GcdR_TrpI_HvrB_AmpR_like; cd08432
335659002673	dimerization interface [polypeptide binding]; other site
335659002674	substrate binding pocket [chemical binding]; other site
335659002675	Domain of unknown function (DUF1127); Region: DUF1127; pfam06568
335659002676	Acetyltransferases [General function prediction only]; Region: RimI; COG0456
335659002677	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
335659002678	Coenzyme A binding pocket [chemical binding]; other site
335659002679	enoyl-CoA hydratase; Provisional; Region: PRK06688
335659002680	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
335659002681	substrate binding site [chemical binding]; other site
335659002682	oxyanion hole (OAH) forming residues; other site
335659002683	trimer interface [polypeptide binding]; other site
335659002684	Short-chain alcohol dehydrogenase of unknown specificity [General function prediction only]; Region: COG4221
335659002685	classical (c) SDR, subgroup  10; Region: SDR_c10; cd05373
335659002686	putative NAD(P) binding site [chemical binding]; other site
335659002687	active site
335659002688	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
335659002689	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
335659002690	active site
335659002691	Zn-dependent alcohol dehydrogenases, class III [Energy production and conversion]; Region: AdhC; COG1062
335659002692	Class III alcohol dehydrogenase; Region: Zn_ADH_class_III; cd08279
335659002693	NAD binding site [chemical binding]; other site
335659002694	catalytic Zn binding site [ion binding]; other site
335659002695	substrate binding site [chemical binding]; other site
335659002696	structural Zn binding site [ion binding]; other site
335659002697	amidase; Provisional; Region: PRK06170
335659002698	Amidase; Region: Amidase; cl11426
335659002699	Uncharacterized family of ferritin-like proteins found in archaea and bacteria; Region: Ferritin_like_AB; cd01045
335659002700	diiron binding motif [ion binding]; other site
335659002701	Uncharacterized conserved protein [Function unknown]; Region: COG1633
335659002702	CCC1-related protein family; Region: CCC1_like_1; cd02437
335659002703	Putative lysophospholipase; Region: Hydrolase_4; pfam12146
335659002704	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
335659002705	Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849
335659002706	Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625
335659002707	Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388
335659002708	C-terminal, alpha helical domain of an unknown subfamily 6 of Glutathione S-transferases; Region: GST_C_6; cd03205
335659002709	dimer interface [polypeptide binding]; other site
335659002710	N-terminal domain interface [polypeptide binding]; other site
335659002711	putative substrate binding pocket (H-site) [chemical binding]; other site
335659002712	2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179
335659002713	Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557
335659002714	Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849
335659002715	Protein of unknown function (DUF3775); Region: DUF3775; pfam12616
335659002716	Zeta-crystallin with NADP-dependent quinone reductase activity (QOR); Region: zeta_crystallin; cd08253
335659002717	NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604
335659002718	NAD(P) binding site [chemical binding]; other site
335659002719	short chain dehydrogenase; Provisional; Region: PRK08339
335659002720	putative beta-ketoacyl acyl carrier protein [ACP] reductase (BKR)-like, SDR; Region: BKR_like_SDR_like; cd05344
335659002721	putative NAD(P) binding site [chemical binding]; other site
335659002722	putative active site [active]
335659002723	Colicin V production protein; Region: Colicin_V; pfam02674
335659002724	short chain dehydrogenase; Provisional; Region: PRK06949
335659002725	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
335659002726	NAD(P) binding site [chemical binding]; other site
335659002727	active site
335659002728	choline dehydrogenase; Validated; Region: PRK02106
335659002729	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
335659002730	GMC oxidoreductase; Region: GMC_oxred_C; pfam05199
335659002731	Coniferyl aldehyde dehydrogenase-like; Region: ALDH_CALDH_CalB; cd07133
335659002732	NAD(P) binding site [chemical binding]; other site
335659002733	catalytic residues [active]
335659002734	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
335659002735	dimerization interface [polypeptide binding]; other site
335659002736	putative DNA binding site [nucleotide binding]; other site
335659002737	putative Zn2+ binding site [ion binding]; other site
335659002738	3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557
335659002739	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
335659002740	NAD(P) binding site [chemical binding]; other site
335659002741	active site
335659002742	Cytochrome c; Region: Cytochrom_C; cl11414
335659002743	Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010
335659002744	Cytochrome C oxidase, cbb3-type, subunit III; Region: Cytochrome_CBB3; pfam13442
335659002745	Exo-beta-1,3-glucanase [Carbohydrate transport and metabolism]; Region: COG5309
335659002746	TOMM system kinase/cyclase fusion protein; Region: TOMM_kin_cyc; TIGR03903
335659002747	cyclase homology domain; Region: CHD; cd07302
335659002748	nucleotidyl binding site; other site
335659002749	metal binding site [ion binding]; metal-binding site
335659002750	dimer interface [polypeptide binding]; other site
335659002751	AAA ATPase domain; Region: AAA_16; pfam13191
335659002752	Tetratricopeptide repeat; Region: TPR_12; pfam13424
335659002753	OpgC protein; Region: OpgC_C; pfam10129
335659002754	Acyltransferase family; Region: Acyl_transf_3; pfam01757
335659002755	Uncharacterized protein conserved in bacteria (DUF2059); Region: DUF2059; pfam09832
335659002756	ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842
335659002757	ABC-2 type transporter; Region: ABC2_membrane; pfam01061
335659002758	ATPase components of various ABC-type transport systems, contain duplicated ATPase [General function prediction only]; Region: COG1123
335659002759	ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230
335659002760	Walker A/P-loop; other site
335659002761	ATP binding site [chemical binding]; other site
335659002762	Q-loop/lid; other site
335659002763	ABC transporter signature motif; other site
335659002764	Walker B; other site
335659002765	D-loop; other site
335659002766	H-loop/switch region; other site
335659002767	ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230
335659002768	Walker A/P-loop; other site
335659002769	ATP binding site [chemical binding]; other site
335659002770	Q-loop/lid; other site
335659002771	ABC transporter signature motif; other site
335659002772	Walker B; other site
335659002773	D-loop; other site
335659002774	H-loop/switch region; other site
335659002775	ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842
335659002776	ABC-2 family transporter protein; Region: ABC2_membrane_2; cl17866
335659002777	putative efflux pump membrane fusion protein; Provisional; Region: PRK03598
335659002778	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
335659002779	HlyD family secretion protein; Region: HlyD_3; pfam13437
335659002780	ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129
335659002781	First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216
335659002782	Walker A/P-loop; other site
335659002783	ATP binding site [chemical binding]; other site
335659002784	Q-loop/lid; other site
335659002785	ABC transporter signature motif; other site
335659002786	Walker B; other site
335659002787	D-loop; other site
335659002788	H-loop/switch region; other site
335659002789	Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215
335659002790	Strictosidine synthase; Region: Str_synth; pfam03088
335659002791	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
335659002792	Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579
335659002793	TM-ABC transporter signature motif; other site
335659002794	Gluconolactonase [Carbohydrate transport and metabolism]; Region: COG3386
335659002795	Strictosidine synthase; Region: Str_synth; pfam03088
335659002796	Periplasmic sugar-binding domain of active transport systems that are members of the type I periplasmic binding protein (PBP1) superfamily; Region: PBP1_ABC_sugar_binding_like; cd01536
335659002797	Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407
335659002798	ligand binding site [chemical binding]; other site
335659002799	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
335659002800	Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579
335659002801	TM-ABC transporter signature motif; other site
335659002802	AMP-binding domain protein; Validated; Region: PRK07529
335659002803	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
335659002804	Uncharacterized subfamily of fatty acid CoA ligase (FACL); Region: FACL_like_4; cd05944
335659002805	acyl-activating enzyme (AAE) consensus motif; other site
335659002806	putative AMP binding site [chemical binding]; other site
335659002807	putative active site [active]
335659002808	putative CoA binding site [chemical binding]; other site
335659002809	DNA-binding transcriptional activator FeaR; Provisional; Region: PRK09685
335659002810	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
335659002811	Periplasmic binding protein; Region: Peripla_BP_6; pfam13458
335659002812	Periplasmic solute-binding domain of active transport proteins that belong to the type I periplasmic binding fold protein family; Region: PBP1_SBP_like_1; cd06327
335659002813	putative ligand binding site [chemical binding]; other site
335659002814	acyl-CoA synthetase; Validated; Region: PRK08316
335659002815	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
335659002816	Bacterial Bile acid CoA ligases and similar proteins; Region: BACL_like; cd05929
335659002817	acyl-activating enzyme (AAE) consensus motif; other site
335659002818	acyl-activating enzyme (AAE) consensus motif; other site
335659002819	putative AMP binding site [chemical binding]; other site
335659002820	putative active site [active]
335659002821	putative CoA binding site [chemical binding]; other site
335659002822	Medium chain dehydrogenases/reductase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR7; cd08276
335659002823	NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604
335659002824	putative NAD(P) binding site [chemical binding]; other site
335659002825	hypothetical protein; Validated; Region: PRK07581
335659002826	Homoserine acetyltransferase [Amino acid transport and metabolism]; Region: MET2; COG2021
335659002827	This CD includes the putative hydrocarbon oxygenase, MocD, a bacterial rhizopine (3-O-methyl-scyllo-inosamine, 3-O-MSI) oxygenase, and other related proteins. It has been proposed that MocD, MocE (Rieske-like ferredoxin), and MocF (ferredoxin reductase)...; Region: Rhizopine-oxygenase-like; cd03511
335659002828	Fatty acid desaturase; Region: FA_desaturase; pfam00487
335659002829	putative di-iron ligands [ion binding]; other site
335659002830	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
335659002831	Response regulator receiver domain; Region: Response_reg; pfam00072
335659002832	active site
335659002833	phosphorylation site [posttranslational modification]
335659002834	intermolecular recognition site; other site
335659002835	dimerization interface [polypeptide binding]; other site
335659002836	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
335659002837	Predicted transcriptional regulator [Transcription]; Region: COG2378
335659002838	HTH domain; Region: HTH_11; pfam08279
335659002839	WYL domain; Region: WYL; pfam13280
335659002840	Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625
335659002841	GST_N family, Saccharomyces cerevisiae GTT1-like subfamily; composed of predominantly uncharacterized proteins with similarity to the S. cerevisiae GST protein, GTT1, and the Schizosaccharomyces pombe GST-III. GSTs are cytosolic dimeric proteins involved...; Region: GST_N_GTT1_like; cd03046
335659002842	putative C-terminal domain interface [polypeptide binding]; other site
335659002843	putative GSH binding site (G-site) [chemical binding]; other site
335659002844	putative dimer interface [polypeptide binding]; other site
335659002845	C-terminal, alpha helical domain of an unknown subfamily 8 of Glutathione S-transferases; Region: GST_C_8; cd03207
335659002846	dimer interface [polypeptide binding]; other site
335659002847	N-terminal domain interface [polypeptide binding]; other site
335659002848	putative substrate binding pocket (H-site) [chemical binding]; other site
335659002849	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
335659002850	Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024
335659002851	substrate binding site [chemical binding]; other site
335659002852	oxyanion hole (OAH) forming residues; other site
335659002853	trimer interface [polypeptide binding]; other site
335659002854	Ion channel; Region: Ion_trans_2; pfam07885
335659002855	cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664
335659002856	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
335659002857	ligand binding site [chemical binding]; other site
335659002858	flexible hinge region; other site
335659002859	Protein of unknown function (DUF3307); Region: DUF3307; pfam11750
335659002860	Predicted Fe-S-cluster oxidoreductase [General function prediction only]; Region: COG0727
335659002861	Predicted transcriptional regulator [Transcription]; Region: COG2378
335659002862	HTH domain; Region: HTH_11; pfam08279
335659002863	WYL domain; Region: WYL; pfam13280
335659002864	GST_N family, Metaxin subfamily, Metaxin-like proteins; a heterogenous group of proteins, predominantly uncharacterized, with similarity to metaxins and GSTs. Metaxin 1 is a component of a preprotein import complex of the mitochondrial outer membrane. It...; Region: GST_N_Metaxin_like; cd03080
335659002865	Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625
335659002866	putative C-terminal domain interface [polypeptide binding]; other site
335659002867	putative GSH binding site [chemical binding]; other site
335659002868	putative dimer interface [polypeptide binding]; other site
335659002869	C-terminal, alpha helical domain of Metaxin and related proteins; Region: GST_C_Metaxin; cd03193
335659002870	putative N-terminal domain interface [polypeptide binding]; other site
335659002871	Type I periplasmic binding component of ABC (ATPase Binding Cassette)-type transport systems that are predicted to be involved in uptake of amino acids; Region: PBP1_ABC-type_HAAT_like; cd06333
335659002872	ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683
335659002873	putative ligand binding site [chemical binding]; other site
335659002874	4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586
335659002875	active site
335659002876	3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557
335659002877	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
335659002878	NAD(P) binding site [chemical binding]; other site
335659002879	active site
335659002880	feruloyl-CoA synthase; Reviewed; Region: PRK08180
335659002881	Feruloyl-CoA synthetase (FCS); Region: FCS; cd05921
335659002882	acyl-activating enzyme (AAE) consensus motif; other site
335659002883	putative AMP binding site [chemical binding]; other site
335659002884	putative active site [active]
335659002885	putative CoA binding site [chemical binding]; other site
335659002886	Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024
335659002887	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
335659002888	substrate binding site [chemical binding]; other site
335659002889	oxyanion hole (OAH) forming residues; other site
335659002890	trimer interface [polypeptide binding]; other site
335659002891	hypothetical protein; Provisional; Region: PRK00872
335659002892	DctM-like transporters; Region: DctM; pfam06808
335659002893	TRAP-type C4-dicarboxylate transport system, large permease component [Carbohydrate transport and metabolism]; Region: DctQ; COG1593
335659002894	Tripartite ATP-independent periplasmic transporters, DctQ component; Region: DctQ; pfam04290
335659002895	Bacterial extracellular solute-binding protein, family 7; Region: SBP_bac_7; cl15441
335659002896	4-hydroxybenzoate 3-monooxygenase; Validated; Region: PRK08243
335659002897	hypothetical protein; Provisional; Region: PRK07236
335659002898	PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria.  Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443
335659002899	CoenzymeA binding site [chemical binding]; other site
335659002900	Thioesterase-like superfamily; Region: 4HBT_3; pfam13622
335659002901	subunit interaction site [polypeptide binding]; other site
335659002902	PHB binding site; other site
335659002903	Transcriptional regulator [Transcription]; Region: LysR; COG0583
335659002904	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
335659002905	The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_2; cd08471
335659002906	putative effector binding pocket; other site
335659002907	putative dimerization interface [polypeptide binding]; other site
335659002908	Pyridoxine 5'-phosphate (PNP) oxidase-like proteins; Region: PNPOx_like; cl00381
335659002909	ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410
335659002910	ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224
335659002911	Walker A/P-loop; other site
335659002912	ATP binding site [chemical binding]; other site
335659002913	Q-loop/lid; other site
335659002914	ABC transporter signature motif; other site
335659002915	Walker B; other site
335659002916	D-loop; other site
335659002917	H-loop/switch region; other site
335659002918	ABC-type branched-chain amino acid transport system, permease component [Amino acid transport and metabolism]; Region: LivM; COG4177
335659002919	Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581
335659002920	TM-ABC transporter signature motif; other site
335659002921	ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411
335659002922	ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219
335659002923	Walker A/P-loop; other site
335659002924	ATP binding site [chemical binding]; other site
335659002925	Q-loop/lid; other site
335659002926	ABC transporter signature motif; other site
335659002927	Walker B; other site
335659002928	D-loop; other site
335659002929	H-loop/switch region; other site
335659002930	Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582
335659002931	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
335659002932	TM-ABC transporter signature motif; other site
335659002933	helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347
335659002934	MarR family; Region: MarR; pfam01047
335659002935	Formyltransferase, catalytic core domain; Region: FMT_core; cl00395
335659002936	Putative glycerate kinase [Carbohydrate transport and metabolism]; Region: GckA; COG2379
335659002937	Domain of unknown function (DUF4147); Region: DUF4147; pfam13660
335659002938	MOFRL family; Region: MOFRL; pfam05161
335659002939	Type I periplasmic ligand-binding domain of uncharacterized ABC (ATPase Binding Cassette)-type active transport systems that are predicted to be involved in uptake of amino acids, peptides, or inorganic ions; Region: PBP1_ABC_ligand_binding_like_8; cd06343
335659002940	Periplasmic binding protein; Region: Peripla_BP_6; pfam13458
335659002941	putative ligand binding site [chemical binding]; other site
335659002942	Type I periplasmic ligand-binding domain of uncharacterized ABC (ATPase Binding Cassette)-type active transport systems that are predicted to be involved in uptake of amino acids, peptides, or inorganic ions; Region: PBP1_ABC_ligand_binding_like_8; cd06343
335659002943	Periplasmic binding protein; Region: Peripla_BP_6; pfam13458
335659002944	putative ligand binding site [chemical binding]; other site
335659002945	Type I periplasmic ligand-binding domain of uncharacterized ABC (ATPase Binding Cassette)-type active transport systems that are predicted to be involved in uptake of amino acids, peptides, or inorganic ions; Region: PBP1_ABC_ligand_binding_like_8; cd06343
335659002946	Periplasmic binding protein; Region: Peripla_BP_6; pfam13458
335659002947	putative ligand binding site [chemical binding]; other site
335659002948	Type I periplasmic ligand-binding domain of uncharacterized ABC (ATPase Binding Cassette)-type active transport systems that are predicted to be involved in uptake of amino acids, peptides, or inorganic ions; Region: PBP1_ABC_ligand_binding_like_8; cd06343
335659002949	Periplasmic binding protein; Region: Peripla_BP_6; pfam13458
335659002950	putative ligand binding site [chemical binding]; other site
335659002951	ABC-type branched-chain amino acid transport system, permease component [Amino acid transport and metabolism]; Region: LivM; COG4177
335659002952	Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581
335659002953	TM-ABC transporter signature motif; other site
335659002954	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
335659002955	Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582
335659002956	TM-ABC transporter signature motif; other site
335659002957	ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410
335659002958	ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224
335659002959	Walker A/P-loop; other site
335659002960	ATP binding site [chemical binding]; other site
335659002961	Q-loop/lid; other site
335659002962	ABC transporter signature motif; other site
335659002963	Walker B; other site
335659002964	D-loop; other site
335659002965	H-loop/switch region; other site
335659002966	ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411
335659002967	ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219
335659002968	Walker A/P-loop; other site
335659002969	ATP binding site [chemical binding]; other site
335659002970	Q-loop/lid; other site
335659002971	ABC transporter signature motif; other site
335659002972	Walker B; other site
335659002973	D-loop; other site
335659002974	H-loop/switch region; other site
335659002975	Transcriptional regulator [Transcription]; Region: IclR; COG1414
335659002976	IclR helix-turn-helix domain; Region: HTH_IclR; pfam09339
335659002977	Bacterial transcriptional regulator; Region: IclR; pfam01614
335659002978	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
335659002979	multifunctional fatty acid oxidation complex subunit alpha; Reviewed; Region: fadB; PRK11730
335659002980	substrate binding site [chemical binding]; other site
335659002981	oxyanion hole (OAH) forming residues; other site
335659002982	trimer interface [polypeptide binding]; other site
335659002983	3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737
335659002984	3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725
335659002985	3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725
335659002986	dicarboxylate--CoA ligase PimA; Region: pimA; TIGR03205
335659002987	Prokaryotic long-chain fatty acid CoA synthetases similar to Escherichia coli FadD; Region: FC-FACS_FadD_like; cd05936
335659002988	acyl-activating enzyme (AAE) consensus motif; other site
335659002989	putative AMP binding site [chemical binding]; other site
335659002990	putative active site [active]
335659002991	putative CoA binding site [chemical binding]; other site
335659002992	pimeloyl-CoA dehydrogenase, large subunit; Region: pimC_large; TIGR03204
335659002993	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
335659002994	active site
335659002995	pimeloyl-CoA dehydrogenase, small subunit; Region: pimD_small; TIGR03203
335659002996	Acyl-CoA dehydrogenase; Region: ACAD; cd00567
335659002997	active site
335659002998	3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK07231
335659002999	classical (c) SDRs; Region: SDR_c; cd05233
335659003000	NAD(P) binding site [chemical binding]; other site
335659003001	active site
335659003002	Domain of unknown function, appears to be related to a diverse group of endonucleases; Region: Endonuclease_DUF559; cd01038
335659003003	putative active site [active]
335659003004	Glycerol kinase [Energy production and conversion]; Region: GlpK; COG0554
335659003005	Escherichia coli glycerol kinase-like proteins; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_EcGK_like; cd07786
335659003006	N- and C-terminal domain interface [polypeptide binding]; other site
335659003007	active site
335659003008	MgATP binding site [chemical binding]; other site
335659003009	catalytic site [active]
335659003010	metal binding site [ion binding]; metal-binding site
335659003011	glycerol binding site [chemical binding]; other site
335659003012	homotetramer interface [polypeptide binding]; other site
335659003013	homodimer interface [polypeptide binding]; other site
335659003014	FBP binding site [chemical binding]; other site
335659003015	protein IIAGlc interface [polypeptide binding]; other site
335659003016	Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583
335659003017	AAA domain; Region: AAA_25; pfam13481
335659003018	RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233
335659003019	Walker A motif; other site
335659003020	ATP binding site [chemical binding]; other site
335659003021	Walker B motif; other site
335659003022	Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599
335659003023	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
335659003024	Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625
335659003025	Glutathione S-transferase (GST) family, N-terminal domain; a large, diverse group of cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of  glutathione (GSH) with a wide range of endogenous and xenobiotic...; Region: GST_N_family; cd00570
335659003026	C-terminal domain interface [polypeptide binding]; other site
335659003027	GSH binding site (G-site) [chemical binding]; other site
335659003028	dimer interface [polypeptide binding]; other site
335659003029	C-terminal, alpha helical domain of an unknown subfamily 6 of Glutathione S-transferases; Region: GST_C_6; cd03205
335659003030	dimer interface [polypeptide binding]; other site
335659003031	N-terminal domain interface [polypeptide binding]; other site
335659003032	putative substrate binding pocket (H-site) [chemical binding]; other site
335659003033	B12-dependent methionine synthase; Provisional; Region: metH; PRK09490
335659003034	Methionine synthase I (cobalamin-dependent), methyltransferase domain [Amino acid transport and metabolism]; Region: MetH; COG0646
335659003035	MeTr subgroup of pterin binding enzymes. This family includes cobalamin-dependent methyltransferases such as methyltetrahydrofolate, corrinoid iron-sulfur protein methyltransferase (MeTr) and methionine synthase (MetH).  Cobalamin-dependent...; Region: MeTr; cd00740
335659003036	substrate binding pocket [chemical binding]; other site
335659003037	B12 binding domain of methionine synthase. This domain binds methylcobalamin, which it uses as an intermediate methyl carrier from methyltetrahydrofolate (CH3H4folate) to homocysteine (Hcy); Region: methionine_synthase_B12_BD; cd02069
335659003038	B12 binding site [chemical binding]; other site
335659003039	cobalt ligand [ion binding]; other site
335659003040	Vitamin B12 dependent methionine synthase, activation domain; Region: Met_synt_B12; pfam02965
335659003041	Methylenetetrahydrofolate reductase (MTHFR). 5,10-Methylenetetrahydrofolate is reduced to 5-methyltetrahydrofolate by methylenetetrahydrofolate reductase, a cytoplasmic, NAD(P)-dependent enzyme. 5-methyltetrahydrofolate is utilized by methionine synthase...; Region: MTHFR; cd00537
335659003042	FAD binding site [chemical binding]; other site
335659003043	luciferase family oxidoreductase, group 1; Region: oxido_grp_1; TIGR03558
335659003044	probable oxidoreductase, LLM family; Region: LLM_2I7G; TIGR03858
335659003045	prephenate dehydratase; Provisional; Region: PRK11899
335659003046	Prephenate dehydratase; Region: PDT; pfam00800
335659003047	C-terminal ACT domain of the bifunctional chorismate mutase-prephenate dehydratase (CM-PDT) enzyme and the prephenate dehydratase (PDT) enzyme; Region: ACT_CM-PDT; cd04905
335659003048	putative L-Phe binding site [chemical binding]; other site
335659003049	3-deoxy-manno-octulosonate cytidylyltransferase; Provisional; Region: PRK05450
335659003050	CMP-KDO synthetase catalyzes the activation of KDO which is an essential component of the lipopolysaccharide; Region: CMP-KDO-Synthetase; cd02517
335659003051	Ligand binding site; other site
335659003052	oligomer interface; other site
335659003053	Cytochrome c2 [Energy production and conversion]; Region: COG3474
335659003054	ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166
335659003055	The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_14; cd08497
335659003056	ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166
335659003057	The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_14; cd08497
335659003058	ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG4174
335659003059	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
335659003060	dimer interface [polypeptide binding]; other site
335659003061	conserved gate region; other site
335659003062	putative PBP binding loops; other site
335659003063	ABC-ATPase subunit interface; other site
335659003064	ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG4239
335659003065	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
335659003066	dimer interface [polypeptide binding]; other site
335659003067	conserved gate region; other site
335659003068	ABC-ATPase subunit interface; other site
335659003069	ABC-type uncharacterized transport system, duplicated ATPase component [General function prediction only]; Region: COG4172
335659003070	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
335659003071	Walker A/P-loop; other site
335659003072	ATP binding site [chemical binding]; other site
335659003073	Q-loop/lid; other site
335659003074	ABC transporter signature motif; other site
335659003075	Walker B; other site
335659003076	D-loop; other site
335659003077	H-loop/switch region; other site
335659003078	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097
335659003079	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
335659003080	Walker A/P-loop; other site
335659003081	ATP binding site [chemical binding]; other site
335659003082	Q-loop/lid; other site
335659003083	ABC transporter signature motif; other site
335659003084	Walker B; other site
335659003085	D-loop; other site
335659003086	H-loop/switch region; other site
335659003087	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097
335659003088	Src Homology 3 domain superfamily; Region: SH3; cl17036
335659003089	Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791
335659003090	NlpC/P60 family; Region: NLPC_P60; pfam00877
335659003091	Leucyl aminopeptidase [Amino acid transport and metabolism]; Region: PepB; COG0260
335659003092	Cytosol aminopeptidase family, N-terminal and catalytic domains.  Family M17 contains zinc- and manganese-dependent exopeptidases ( EC  3.4.11.1), including leucine aminopeptidase. They catalyze removal of amino acids from the N-terminus of a protein and...; Region: Peptidase_M17; cd00433
335659003093	interface (dimer of trimers) [polypeptide binding]; other site
335659003094	Substrate-binding/catalytic site; other site
335659003095	Zn-binding sites [ion binding]; other site
335659003096	Predicted phosphohydrolases [General function prediction only]; Region: Icc; COG1409
335659003097	metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995
335659003098	active site
335659003099	metal binding site [ion binding]; metal-binding site
335659003100	metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995
335659003101	Flp pilus assembly protein TadD, contains TPR repeats [Intracellular trafficking and secretion]; Region: TadD; COG5010
335659003102	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
335659003103	TPR motif; other site
335659003104	binding surface
335659003105	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
335659003106	binding surface
335659003107	TPR motif; other site
335659003108	Flp pilus assembly protein TadC [Cell motility and secretion / Intracellular trafficking and secretion]; Region: TadC; COG2064
335659003109	Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482
335659003110	Flp pilus assembly protein TadB [Intracellular trafficking and secretion]; Region: TadB; COG4965
335659003111	Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482
335659003112	Flp pilus assembly protein, ATPase CpaF [Intracellular trafficking and secretion]; Region: CpaF; COG4962
335659003113	Type IV secretory pathway component VirB11, and related ATPases. The homohexamer, VirB11 is one of eleven Vir proteins, which are required for T-pilus biogenesis and virulence in the transfer of T-DNA from the Ti (tumor-inducing) plasmid of bacterial to...; Region: VirB11-like_ATPase; cd01130
335659003114	ATP binding site [chemical binding]; other site
335659003115	Walker A motif; other site
335659003116	hexamer interface [polypeptide binding]; other site
335659003117	Walker B motif; other site
335659003118	Flp pilus assembly protein, ATPase CpaE [Intracellular trafficking and secretion]; Region: CpaE; COG4963
335659003119	This protein family consists of proteins similar to the cpaE protein of the Caulobacter pilus assembly and the orf4 protein of Actinobacillus pilus formation gene cluster. The function of these proteins are unkown. The Caulobacter pilus assembly contains...; Region: CpaE_like; cd03111
335659003120	Pilus biogenesis CpaD protein (pilus_cpaD); Region: Pilus_CpaD; pfam09476
335659003121	Type IV pili component [Cell motility and secretion]; Region: COG5461
335659003122	Flp pilus assembly protein, secretin CpaC [Intracellular trafficking and secretion]; Region: CpaC; COG4964
335659003123	Pilus formation protein N terminal region; Region: T2SS-T3SS_pil_N; pfam13629
335659003124	BON domain; Region: BON; pfam04972
335659003125	Bacterial type II and III secretion system protein; Region: Secretin; pfam00263
335659003126	Flp pilus assembly protein CpaB [Intracellular trafficking and secretion]; Region: CpaB; COG3745
335659003127	SAF domains of the flagella basal body P-ring formation protein FlgA and the flp pilus assembly CpaB; Region: SAF_CpaB_FlgA_like; cd11614
335659003128	Flp pilus assembly protein, protease CpaA [Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: CpaA; COG4960
335659003129	Flp pilus assembly protein, pilin Flp [Intracellular trafficking and secretion]; Region: Flp; COG3847
335659003130	Sterol desaturase [Lipid metabolism]; Region: ERG3; COG3000
335659003131	Fatty acid hydroxylase superfamily; Region: FA_hydroxylase; pfam04116
335659003132	Pilus formation protein N terminal region; Region: T2SS-T3SS_pil_N; pfam13629
335659003133	Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea.  CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458
335659003134	DNA-binding site [nucleotide binding]; DNA binding site
335659003135	RNA-binding motif; other site
335659003136	S1_IF1: Translation Initiation Factor IF1, S1-like RNA-binding domain. IF1 contains an S1-like RNA-binding domain, which is found in a wide variety of RNA-associated proteins. Translation initiation includes a number of interrelated steps preceding the...; Region: S1_IF1; cd04451
335659003137	rRNA binding site [nucleotide binding]; other site
335659003138	predicted 30S ribosome binding site; other site
335659003139	Superfamily II DNA and RNA helicases [DNA replication, recombination, and repair / Transcription / Translation, ribosomal structure and biogenesis]; Region: SrmB; COG0513
335659003140	DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker  B motif; Region: DEADc; cd00268
335659003141	ATP binding site [chemical binding]; other site
335659003142	Mg++ binding site [ion binding]; other site
335659003143	motif III; other site
335659003144	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
335659003145	nucleotide binding region [chemical binding]; other site
335659003146	ATP-binding site [chemical binding]; other site
335659003147	Periplasmic binding protein; Region: Peripla_BP_6; pfam13458
335659003148	Periplasmic component (FmdD) of an active transport system for short-chain amides and urea (FmdDEF); Region: PBP1_FmdD_like; cd06355
335659003149	putative ligand binding site [chemical binding]; other site
335659003150	Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582
335659003151	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
335659003152	TM-ABC transporter signature motif; other site
335659003153	ABC-type branched-chain amino acid transport system, permease component [Amino acid transport and metabolism]; Region: LivM; COG4177
335659003154	Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581
335659003155	TM-ABC transporter signature motif; other site
335659003156	urea ABC transporter, ATP-binding protein UrtD; Region: urea_trans_UrtD; TIGR03411
335659003157	ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219
335659003158	Walker A/P-loop; other site
335659003159	ATP binding site [chemical binding]; other site
335659003160	Q-loop/lid; other site
335659003161	ABC transporter signature motif; other site
335659003162	Walker B; other site
335659003163	D-loop; other site
335659003164	H-loop/switch region; other site
335659003165	urea ABC transporter, ATP-binding protein UrtE; Region: urea_trans_UrtE; TIGR03410
335659003166	ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224
335659003167	Walker A/P-loop; other site
335659003168	ATP binding site [chemical binding]; other site
335659003169	Q-loop/lid; other site
335659003170	ABC transporter signature motif; other site
335659003171	Walker B; other site
335659003172	D-loop; other site
335659003173	H-loop/switch region; other site
335659003174	UreD urease accessory protein; Region: UreD; pfam01774
335659003175	Urease gamma-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, archaea, fungi and plants. Their primary role is to allow the use...; Region: Urease_gamma; cd00390
335659003176	alpha-gamma subunit interface [polypeptide binding]; other site
335659003177	beta-gamma subunit interface [polypeptide binding]; other site
335659003178	Urease beta-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, archaea, fungi and plants. Their primary role is to allow the use of...; Region: Urease_beta; cd00407
335659003179	gamma-beta subunit interface [polypeptide binding]; other site
335659003180	alpha-beta subunit interface [polypeptide binding]; other site
335659003181	Domain of unknown function, appears to be related to a diverse group of endonucleases; Region: Endonuclease_DUF559; cd01038
335659003182	putative active site [active]
335659003183	urease subunit alpha; Reviewed; Region: ureC; PRK13207
335659003184	Urease alpha-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, fungi and plants. Their primary role is to allow the use of...; Region: Urease_alpha; cd00375
335659003185	subunit interactions [polypeptide binding]; other site
335659003186	active site
335659003187	flap region; other site
335659003188	Uncharacterized conserved protein [Function unknown]; Region: COG1359
335659003189	Antibiotic biosynthesis monooxygenase; Region: ABM; pfam03992
335659003190	urease accessory protein UreE; Provisional; Region: ureE; PRK13261
335659003191	UreE urease accessory protein. UreE is a metallochaperone assisting the insertion of a Ni2+ ion in the active site of urease, an important step in the in vivo assembly of urease, an enzyme that hydrolyses urea into ammonia and carbamic acid. The...; Region: UreE; cd00571
335659003192	dimer interface [polypeptide binding]; other site
335659003193	catalytic residues [active]
335659003194	Urease accessory protein UreF [Posttranslational modification, protein turnover, chaperones]; Region: UreF; COG0830
335659003195	UreF; Region: UreF; pfam01730
335659003196	The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203
335659003197	This domain is found in the extracellular portion of receptor-like proteins - such as serine/threonine kinases and adenylyl cyclases; Region: CHASE; smart01079
335659003198	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920
335659003199	HWE histidine kinase; Region: HWE_HK; pfam07536
335659003200	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
335659003201	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
335659003202	OpgC protein; Region: OpgC_C; pfam10129
335659003203	Bacterial protein of unknown function (DUF883); Region: DUF883; pfam05957
335659003204	Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628
335659003205	Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376
335659003206	L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734
335659003207	Protein of unknown function (DUF2865); Region: DUF2865; pfam11064
335659003208	Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840
335659003209	HAMP domain; Region: HAMP; pfam00672
335659003210	dimerization interface [polypeptide binding]; other site
335659003211	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
335659003212	dimer interface [polypeptide binding]; other site
335659003213	putative CheW interface [polypeptide binding]; other site
335659003214	HAMP domain; Region: HAMP; pfam00672
335659003215	dimerization interface [polypeptide binding]; other site
335659003216	Protein of unknown function (DUF3042); Region: DUF3042; pfam11240
335659003217	Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283
335659003218	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
335659003219	dimer interface [polypeptide binding]; other site
335659003220	putative CheW interface [polypeptide binding]; other site
335659003221	malate synthase G; Provisional; Region: PRK02999
335659003222	active site
335659003223	bifunctional sulfate adenylyltransferase subunit 1/adenylylsulfate kinase protein; Provisional; Region: PRK05506
335659003224	CysN, together with protein CysD, forms the ATP sulfurylase (ATPS) complex; Region: CysN_ATPS; cd04166
335659003225	CysD dimerization site [polypeptide binding]; other site
335659003226	G1 box; other site
335659003227	putative GEF interaction site [polypeptide binding]; other site
335659003228	GTP/Mg2+ binding site [chemical binding]; other site
335659003229	Switch I region; other site
335659003230	G2 box; other site
335659003231	G3 box; other site
335659003232	Switch II region; other site
335659003233	G4 box; other site
335659003234	G5 box; other site
335659003235	CysN_NodQ_II: This subfamily represents the domain II of the large subunit of ATP sulfurylase (ATPS): CysN or the N-terminal portion of NodQ, found mainly in proteobacteria and homologous to the domain II of EF-Tu. Escherichia coli ATPS consists of CysN...; Region: CysN_NodQ_II; cd03695
335659003236	TCysN_NoDQ_II: This subfamily represents the domain II of the large subunit of ATP sulfurylase (ATPS): CysN or the N-terminal portion of NodQ, found mainly in proteobacteria and homologous to the domain II of EF-Tu. Escherichia coli ATPS consists of CysN...; Region: CysN_NoDQ_III; cd04095
335659003237	Adenosine 5'-phosphosulfate kinase (APSK) catalyzes the phosphorylation of adenosine 5'-phosphosulfate to form 3'-phosphoadenosine 5'-phosphosulfate (PAPS). The end-product PAPS is a biologically "activated" sulfate form...; Region: APSK; cd02027
335659003238	ligand-binding site [chemical binding]; other site
335659003239	sulfate adenylyltransferase, small subunit; Region: CysD; TIGR02039
335659003240	This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713
335659003241	Active Sites [active]
335659003242	siroheme synthase; Provisional; Region: cysG; PRK10637
335659003243	Putative NAD(P)-binding; Region: NAD_binding_7; pfam13241
335659003244	Sirohaem synthase dimerisation region; Region: CysG_dimeriser; pfam10414
335659003245	Uroporphyrin-III C-methyltransferase (S-Adenosyl-L-methionine:uroporphyrinogen III methyltransferase, SUMT); Region: SUMT; cd11642
335659003246	active site
335659003247	SAM binding site [chemical binding]; other site
335659003248	homodimer interface [polypeptide binding]; other site
335659003249	Protein of unknown function (DUF2849); Region: DUF2849; pfam11011
335659003250	Sulfite reductase, beta subunit (hemoprotein) [Inorganic ion transport and metabolism]; Region: CysI; COG0155
335659003251	Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460
335659003252	Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460
335659003253	Bacterial protein of unknown function (DUF934); Region: DUF934; pfam06073
335659003254	3'-phosphoadenosine 5'-phosphosulfate sulfotransferase (PAPS reductase)/FAD synthetase and related enzymes [Amino acid transport and metabolism / Coenzyme metabolism]; Region: CysH; COG0175
335659003255	This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713
335659003256	Active Sites [active]
335659003257	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
335659003258	Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531
335659003259	substrate binding pocket [chemical binding]; other site
335659003260	membrane-bound complex binding site; other site
335659003261	hinge residues; other site
335659003262	ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555
335659003263	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
335659003264	dimer interface [polypeptide binding]; other site
335659003265	conserved gate region; other site
335659003266	putative PBP binding loops; other site
335659003267	ABC-ATPase subunit interface; other site
335659003268	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
335659003269	dimer interface [polypeptide binding]; other site
335659003270	conserved gate region; other site
335659003271	putative PBP binding loops; other site
335659003272	ABC-ATPase subunit interface; other site
335659003273	ABC-type sulfate/molybdate transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: CysA; COG1118
335659003274	ATP-binding cassette domain of the sulfate transporter; Region: ABC_CysA_sulfate_importer; cd03296
335659003275	Walker A/P-loop; other site
335659003276	ATP binding site [chemical binding]; other site
335659003277	Q-loop/lid; other site
335659003278	ABC transporter signature motif; other site
335659003279	Walker B; other site
335659003280	D-loop; other site
335659003281	H-loop/switch region; other site
335659003282	TOBE-like domain; Region: TOBE_3; pfam12857
335659003283	SCP_bacterial: SCP-like extracellular protein domain, as found in bacteria and archaea. The wider family of SCP containing proteins includes plant pathogenesis-related protein 1 (PR-1), CRISPs, mammalian cysteine-rich secretory proteins, and allergen 5...; Region: SCP_bacterial; cd05379
335659003284	Predicted esterase of the alpha-beta hydrolase superfamily [General function prediction only]; Region: RssA; COG1752
335659003285	Hypothetical patatin similar to Z1214 protein of Escherichia coli; Region: Pat_hypo_Ecoli_Z1214_like; cd07209
335659003286	active site
335659003287	nucleophile elbow; other site
335659003288	Patatin phospholipase; Region: DUF3734; pfam12536
335659003289	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
335659003290	3-hydroxybutyrate dehydrogenase; Region: PHB_DH; TIGR01963
335659003291	NAD(P) binding site [chemical binding]; other site
335659003292	active site
335659003293	Sulfite exporter TauE/SafE; Region: TauE; pfam01925
335659003294	ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410
335659003295	ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224
335659003296	Walker A/P-loop; other site
335659003297	ATP binding site [chemical binding]; other site
335659003298	Q-loop/lid; other site
335659003299	ABC transporter signature motif; other site
335659003300	Walker B; other site
335659003301	D-loop; other site
335659003302	H-loop/switch region; other site
335659003303	ABC-type branched-chain amino acid transport system, permease component [Amino acid transport and metabolism]; Region: LivM; COG4177
335659003304	Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581
335659003305	TM-ABC transporter signature motif; other site
335659003306	ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411
335659003307	ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219
335659003308	Walker A/P-loop; other site
335659003309	ATP binding site [chemical binding]; other site
335659003310	Q-loop/lid; other site
335659003311	ABC transporter signature motif; other site
335659003312	Walker B; other site
335659003313	D-loop; other site
335659003314	H-loop/switch region; other site
335659003315	Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582
335659003316	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
335659003317	TM-ABC transporter signature motif; other site
335659003318	Periplasmic binding protein; Region: Peripla_BP_6; pfam13458
335659003319	Periplasmic solute-binding domain of active transport proteins that belong to the type I periplasmic binding fold protein family; Region: PBP1_SBP_like_1; cd06327
335659003320	putative ligand binding site [chemical binding]; other site
335659003321	Nitrilases, cyanide hydratase (CH)s, and similar proteins (class 1 nitrilases); Region: nitrilases_CHs; cd07564
335659003322	Predicted amidohydrolase [General function prediction only]; Region: COG0388
335659003323	putative active site [active]
335659003324	catalytic triad [active]
335659003325	putative dimer interface [polypeptide binding]; other site
335659003326	Transcriptional regulator [Transcription]; Region: LysR; COG0583
335659003327	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
335659003328	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
335659003329	dimerization interface [polypeptide binding]; other site
335659003330	Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244
335659003331	Wzx, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_Wzx_like; cd13128
335659003332	Disulphide bond corrector protein DsbC; Region: DsbC; cl15830
335659003333	hypothetical protein; Validated; Region: PRK00228
335659003334	Taurine catabolism dioxygenase TauD, TfdA family; Region: TauD; pfam02668
335659003335	Probable taurine catabolism dioxygenase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: TauD; COG2175
335659003336	3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653
335659003337	classical (c) SDRs; Region: SDR_c; cd05233
335659003338	NAD(P) binding site [chemical binding]; other site
335659003339	active site
335659003340	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
335659003341	NAD(P) binding site [chemical binding]; other site
335659003342	active site
335659003343	Bacterial protein of unknown function (DUF883); Region: DUF883; cl01888
335659003344	SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cl01053
335659003345	active site
335659003346	oxyanion hole [active]
335659003347	SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cl01053
335659003348	catalytic triad [active]
335659003349	Transglycosylase SLT domain; Region: SLT_2; pfam13406
335659003350	murein hydrolase B; Provisional; Region: PRK10760; cl17906
335659003351	Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471
335659003352	Prokaryotic UGPase catalyses the synthesis of UDP-glucose; Region: UGPase_prokaryotic; cd02541
335659003353	dTDP-glucose pyrophosphorylase [Cell envelope biogenesis, outer membrane]; Region: RfbA; COG1209
335659003354	active site
335659003355	tetramer interface; other site
335659003356	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
335659003357	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
335659003358	metal binding site [ion binding]; metal-binding site
335659003359	active site
335659003360	I-site; other site
335659003361	7TMR-DISM extracellular 2; Region: 7TMR-DISMED2; pfam07696
335659003362	7TM diverse intracellular signalling; Region: 7TMR-DISM_7TM; pfam07695
335659003363	Predicted acyltransferases [Lipid metabolism]; Region: COG1835
335659003364	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
335659003365	PAS fold; Region: PAS_3; pfam08447
335659003366	putative active site [active]
335659003367	heme pocket [chemical binding]; other site
335659003368	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
335659003369	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
335659003370	metal binding site [ion binding]; metal-binding site
335659003371	active site
335659003372	I-site; other site
335659003373	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
335659003374	putative NAD(P)H quinone oxidoreductase, PIG3 family; Region: quinone_pig3; TIGR02824
335659003375	PIG3 p53-inducible quinone oxidoreductase; Region: p53_inducible_oxidoreductase; cd05276
335659003376	NAD(P) binding site [chemical binding]; other site
335659003377	Protein of unknown function (DUF1192); Region: DUF1192; pfam06698
335659003378	Protein of unknown function (DUF1465); Region: DUF1465; pfam07323
335659003379	50S ribosomal protein L31; Reviewed; Region: rpmE; PRK00528
335659003380	ABC transporter, permease/ATP-binding protein; Region: MsbA_rel; TIGR02204
335659003381	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
335659003382	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
335659003383	Walker A/P-loop; other site
335659003384	ATP binding site [chemical binding]; other site
335659003385	Q-loop/lid; other site
335659003386	ABC transporter signature motif; other site
335659003387	Walker B; other site
335659003388	D-loop; other site
335659003389	H-loop/switch region; other site
335659003390	nitrilotriacetate monoxygenase oxidizes nitrilotriacetate utilizing reduced flavin mononucleotide (FMNH2) and oxygen. The FMNH2 is provided by an NADH:flavin mononucleotide (FMN) oxidorductase that uses NADH to reduce FMN to FMNH2; Region: Nitrilotriacetate_monoxgenase; cd01095
335659003391	FMN-dependent oxidoreductase, nitrilotriacetate monooxygenase family; Region: FMN_nitrolo; TIGR03860
335659003392	active site
335659003393	non-prolyl cis peptide bond; other site
335659003394	OsmC-like protein; Region: OsmC; pfam02566
335659003395	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
335659003396	substrate binding pocket [chemical binding]; other site
335659003397	ABC transporter, substrate-binding protein, aliphatic sulfonates family; Region: SsuA_fam; TIGR01728
335659003398	membrane-bound complex binding site; other site
335659003399	hinge residues; other site
335659003400	ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116
335659003401	ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293
335659003402	Walker A/P-loop; other site
335659003403	ATP binding site [chemical binding]; other site
335659003404	Q-loop/lid; other site
335659003405	ABC transporter signature motif; other site
335659003406	Walker B; other site
335659003407	D-loop; other site
335659003408	H-loop/switch region; other site
335659003409	ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600
335659003410	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
335659003411	dimer interface [polypeptide binding]; other site
335659003412	conserved gate region; other site
335659003413	putative PBP binding loops; other site
335659003414	ABC-ATPase subunit interface; other site
335659003415	Predicted metal-dependent enzyme of the double-stranded beta helix superfamily [General function prediction only]; Region: COG5553
335659003416	Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302
335659003417	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
335659003418	Coenzyme A binding pocket [chemical binding]; other site
335659003419	hypothetical protein; Validated; Region: PRK09039
335659003420	Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185
335659003421	ligand binding site [chemical binding]; other site
335659003422	Cyclopropane fatty acid synthase and related methyltransferases [Cell envelope biogenesis, outer membrane]; Region: Cfa; COG2230
335659003423	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
335659003424	S-adenosylmethionine binding site [chemical binding]; other site
335659003425	periplasmic multidrug efflux lipoprotein precursor; Reviewed; Region: PRK09578
335659003426	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
335659003427	HlyD family secretion protein; Region: HlyD_3; pfam13437
335659003428	Protein of unknown function (DUF2577); Region: DUF2577; pfam10844
335659003429	The (Largely Gram-negative Bacterial) Hydrophobe/Amphiphile Efflux-1 (HAE1) Family; Region: 2A0602; TIGR00915
335659003430	Protein export membrane protein; Region: SecD_SecF; cl14618
335659003431	Solute carrier families 5 and 6-like; solute binding domain; Region: SLC5-6-like_sbd; cl00456
335659003432	Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483
335659003433	IMPase, inositol monophosphatase and related domains. A family of Mg++ dependent phosphatases, inhibited by lithium, many of which may act on inositol monophosphate substrate. They dephosphorylate inositol phosphate to generate inositol, which may be...; Region: IMPase; cd01639
335659003434	active site
335659003435	dimerization interface [polypeptide binding]; other site
335659003436	FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790
335659003437	Sel1-like repeats; Region: SEL1; smart00671
335659003438	Sel1-like repeats; Region: SEL1; smart00671
335659003439	Sel1-like repeats; Region: SEL1; smart00671
335659003440	Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5-; Region: TMP_TenI; cd00564
335659003441	active site
335659003442	pyrophosphate binding site [ion binding]; other site
335659003443	thiamine phosphate binding site [chemical binding]; other site
335659003444	Fructose-1,6-bisphosphate aldolase; Region: FBP_aldolase_I_a; cd00948
335659003445	active site
335659003446	intersubunit interface [polypeptide binding]; other site
335659003447	catalytic residue [active]
335659003448	fructose-bisphosphate aldolase; Provisional; Region: PRK09197
335659003449	Tagatose-1,6-bisphosphate (TBP) aldolase and related Type B Class II aldolases. TBP aldolase is a tetrameric class II aldolase that catalyzes the reversible condensation of dihydroxyacetone phosphate with glyceraldehyde 3-phsophate to produce tagatose 1; Region: TBP_aldolase_IIB; cd00947
335659003450	intersubunit interface [polypeptide binding]; other site
335659003451	active site
335659003452	zinc binding site [ion binding]; other site
335659003453	Na+ binding site [ion binding]; other site
335659003454	Phosphoglycerate kinase; Region: PGK; pfam00162
335659003455	Phosphoglycerate kinase (PGK) is a monomeric enzyme which catalyzes the transfer of the high-energy phosphate group of 1,3-bisphosphoglycerate to ADP, forming ATP and 3-phosphoglycerate. This reaction represents the first of the two substrate-level...; Region: Phosphoglycerate_kinase; cd00318
335659003456	substrate binding site [chemical binding]; other site
335659003457	hinge regions; other site
335659003458	ADP binding site [chemical binding]; other site
335659003459	catalytic site [active]
335659003460	Glyceraldehyde-3-phosphate dehydrogenase/erythrose-4-phosphate dehydrogenase [Carbohydrate transport and metabolism]; Region: GapA; COG0057
335659003461	Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; smart00846
335659003462	Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800
335659003463	Transketolase [Carbohydrate transport and metabolism]; Region: TktA; COG0021
335659003464	Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012
335659003465	TPP-binding site [chemical binding]; other site
335659003466	dimer interface [polypeptide binding]; other site
335659003467	Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033
335659003468	PYR/PP interface [polypeptide binding]; other site
335659003469	dimer interface [polypeptide binding]; other site
335659003470	TPP binding site [chemical binding]; other site
335659003471	Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780
335659003472	Domain of unknown function (DUF4164); Region: DUF4164; pfam13747
335659003473	Cell division protein ZapA; Region: ZapA; pfam05164
335659003474	5,10-methenyltetrahydrofolate synthetase; Region: MTHFS_bact; TIGR02727
335659003475	Deinococcus radiodurans DR1281 and related proteins, metallophosphatase domain; Region: MPP_DR1281; cd07382
335659003476	Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149
335659003477	putative active site [active]
335659003478	metal binding site [ion binding]; metal-binding site
335659003479	homodimer binding site [polypeptide binding]; other site
335659003480	Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Low Specificity D-Threonine Aldolase; Region: PLPDE_III_LS_D-TA; cd06819
335659003481	Predicted amino acid aldolase or racemase [Amino acid transport and metabolism]; Region: COG3616
335659003482	dimer interface [polypeptide binding]; other site
335659003483	active site
335659003484	pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site
335659003485	substrate binding site [chemical binding]; other site
335659003486	catalytic residue [active]
335659003487	Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010
335659003488	Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010
335659003489	Cytochrome c; Region: Cytochrom_C; pfam00034
335659003490	Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738
335659003491	Aerobic-type carbon monoxide dehydrogenase, large subunit CoxL/CutL homologs [Energy production and conversion]; Region: CoxL; COG1529
335659003492	Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; smart01008
335659003493	Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738
335659003494	Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738
335659003495	Aerobic-type carbon monoxide dehydrogenase, small subunit CoxS/CutS homologs [Energy production and conversion]; Region: CoxS; COG2080
335659003496	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
335659003497	catalytic loop [active]
335659003498	iron binding site [ion binding]; other site
335659003499	[2Fe-2S] binding domain; Region: Fer2_2; pfam01799
335659003500	Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283
335659003501	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
335659003502	dimer interface [polypeptide binding]; other site
335659003503	putative CheW interface [polypeptide binding]; other site
335659003504	Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283
335659003505	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
335659003506	dimer interface [polypeptide binding]; other site
335659003507	putative CheW interface [polypeptide binding]; other site
335659003508	hypothetical protein; Validated; Region: PRK00110
335659003509	Holliday junction resolvases (HJRs) are endonucleases that specifically resolve Holliday junction DNA intermediates during homologous recombination. HJR's occur in archaea, bacteria, and in the mitochondria of certain fungi, however this CD...; Region: RuvC_resolvase; cd00529
335659003510	active site
335659003511	putative DNA-binding cleft [nucleotide binding]; other site
335659003512	dimer interface [polypeptide binding]; other site
335659003513	Holliday junction DNA helicase RuvA; Reviewed; Region: ruvA; PRK00116
335659003514	RuvA N terminal domain; Region: RuvA_N; pfam01330
335659003515	Hydroxymethylglutaryl-coenzyme A (HMG-CoA) reductase (HMGR); Region: HMG-CoA_reductase; cl00205
335659003516	Cytidine deaminase zinc-binding domain. These enzymes are Zn dependent. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a water molecule to form a hydroxide ion that performs a nucleophilic attack on...; Region: cytidine_deaminase; cd01283
335659003517	active site
335659003518	catalytic motif [active]
335659003519	Zn binding site [ion binding]; other site
335659003520	Holliday junction DNA helicase RuvB; Reviewed; Region: ruvB; PRK00080
335659003521	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
335659003522	Walker A motif; other site
335659003523	ATP binding site [chemical binding]; other site
335659003524	Walker B motif; other site
335659003525	arginine finger; other site
335659003526	Holliday junction DNA helicase ruvB C-terminus; Region: RuvB_C; pfam05491
335659003527	phosphodiesterase YaeI; Provisional; Region: PRK11340
335659003528	Bacillus subtilis YkuE and related proteins, C-terminal metallophosphatase domain; Region: MPP_YkuE_C; cd07385
335659003529	putative active site [active]
335659003530	putative metal binding site [ion binding]; other site
335659003531	4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586
335659003532	active site
335659003533	Protein of unknown function (DUF1348); Region: DUF1348; pfam07080
335659003534	SnoaL-like domain; Region: SnoaL_2; pfam12680
335659003535	Subgroup of proteins having the Type 1 glutamine amidotransferase (GATase1) domain; Region: GATase1_1; cd01741
335659003536	catalytic triad [active]
335659003537	DNA-binding transcriptional regulator LysR; Provisional; Region: PRK11013
335659003538	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
335659003539	The C-terminal substrate-domain of LysR-type transcriptional regulators involved in the catabolism of opines and that of related regulators, contains the type 2 periplasmic binding fold; Region: PBP2_LysR_opines_like; cd08415
335659003540	putative dimerization interface [polypeptide binding]; other site
335659003541	N-carbamyl-D-amino acid amidohydrolase (DCase, class 6 nitrilases); Region: DCase; cd07569
335659003542	Predicted amidohydrolase [General function prediction only]; Region: COG0388
335659003543	tetramer interface [polypeptide binding]; other site
335659003544	active site
335659003545	catalytic triad [active]
335659003546	dimer interface [polypeptide binding]; other site
335659003547	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
335659003548	Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497
335659003549	substrate binding pocket [chemical binding]; other site
335659003550	membrane-bound complex binding site; other site
335659003551	hinge residues; other site
335659003552	ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215
335659003553	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
335659003554	dimer interface [polypeptide binding]; other site
335659003555	conserved gate region; other site
335659003556	putative PBP binding loops; other site
335659003557	ABC-ATPase subunit interface; other site
335659003558	ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126
335659003559	ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262
335659003560	Walker A/P-loop; other site
335659003561	ATP binding site [chemical binding]; other site
335659003562	Q-loop/lid; other site
335659003563	ABC transporter signature motif; other site
335659003564	Walker B; other site
335659003565	D-loop; other site
335659003566	H-loop/switch region; other site
335659003567	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
335659003568	Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497
335659003569	substrate binding pocket [chemical binding]; other site
335659003570	membrane-bound complex binding site; other site
335659003571	hinge residues; other site
335659003572	Catalytic domain of Helicobacter pylori peptidoglycan deacetylase (HpPgdA) and similar proteins; Region: CE4_HpPgdA_like; cd10938
335659003573	active site
335659003574	catalytic site [active]
335659003575	Zn binding site [ion binding]; other site
335659003576	tetramer interface [polypeptide binding]; other site
335659003577	Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726
335659003578	Asp/Glu/Hydantoin racemase; Region: Asp_Glu_race; cl00518
335659003579	The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_16; cd08502
335659003580	Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496
335659003581	Cytosine deaminase and related metal-dependent hydrolases [Nucleotide transport and metabolism / General function prediction only]; Region: SsnA; COG0402
335659003582	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
335659003583	active site
335659003584	DNA-binding transcriptional regulator LysR; Provisional; Region: PRK11013
335659003585	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
335659003586	The C-terminal substrate-domain of LysR-type transcriptional regulators involved in the catabolism of opines and that of related regulators, contains the type 2 periplasmic binding fold; Region: PBP2_LysR_opines_like; cd08415
335659003587	putative dimerization interface [polypeptide binding]; other site
335659003588	Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416
335659003589	ABC-type Fe3+ transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: AfuA; COG1840
335659003590	ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842
335659003591	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
335659003592	Walker A/P-loop; other site
335659003593	ATP binding site [chemical binding]; other site
335659003594	Q-loop/lid; other site
335659003595	ABC transporter signature motif; other site
335659003596	Walker B; other site
335659003597	D-loop; other site
335659003598	H-loop/switch region; other site
335659003599	TOBE domain; Region: TOBE_2; pfam08402
335659003600	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
335659003601	dimer interface [polypeptide binding]; other site
335659003602	conserved gate region; other site
335659003603	putative PBP binding loops; other site
335659003604	ABC-ATPase subunit interface; other site
335659003605	ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177
335659003606	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
335659003607	dimer interface [polypeptide binding]; other site
335659003608	conserved gate region; other site
335659003609	putative PBP binding loops; other site
335659003610	ABC-ATPase subunit interface; other site
335659003611	Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665
335659003612	2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_4; pfam13510
335659003613	BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324
335659003614	Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665
335659003615	This group of proteins belong to a large family of YjgF/YER057c/UK114-like proteins present in bacteria, archaea, and eukaryotes with no definitive function.  The conserved domain is similar in structure to chorismate mutase but there is no sequence...; Region: YjgF_YER057c_UK114_like_2; cd06150
335659003616	homotrimer interaction site [polypeptide binding]; other site
335659003617	putative active site [active]
335659003618	ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488
335659003619	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
335659003620	Walker A/P-loop; other site
335659003621	ATP binding site [chemical binding]; other site
335659003622	ABC transporter signature motif; other site
335659003623	Walker B; other site
335659003624	D-loop; other site
335659003625	H-loop/switch region; other site
335659003626	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
335659003627	C4-dicarboxylate transporter DctA; Reviewed; Region: PRK01663
335659003628	Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301
335659003629	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
335659003630	glucose-1-dehydrogenase; Provisional; Region: PRK08936
335659003631	NAD(P) binding site [chemical binding]; other site
335659003632	active site
335659003633	Protein of unknown function (DUF1488); Region: DUF1488; pfam07369
335659003634	NAD-dependent deacetylase; Provisional; Region: PRK05333
335659003635	SIRT4: Eukaryotic and prokaryotic group (class2) which includes human sirtuin SIRT4 and several bacterial homologs; and are members of the SIR2 family of proteins, silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein...; Region: SIRT4; cd01409
335659003636	NAD+ binding site [chemical binding]; other site
335659003637	substrate binding site [chemical binding]; other site
335659003638	Zn binding site [ion binding]; other site
335659003639	N-methylhydantoinase A/acetone carboxylase, beta subunit [Amino acid transport and metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: HyuA; COG0145
335659003640	Hydantoinase/oxoprolinase N-terminal region; Region: Hydant_A_N; pfam05378
335659003641	Hydantoinase/oxoprolinase; Region: Hydantoinase_A; pfam01968
335659003642	N-methylhydantoinase B/acetone carboxylase, alpha subunit [Amino acid transport and metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: HyuB; COG0146
335659003643	Hydantoinase B/oxoprolinase; Region: Hydantoinase_B; pfam02538
335659003644	TRAP-type C4-dicarboxylate transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: DctP; COG1638
335659003645	Bacterial extracellular solute-binding protein, family 7; Region: SBP_bac_7; cl15441
335659003646	Tripartite ATP-independent periplasmic transporters, DctQ component; Region: DctQ; pfam04290
335659003647	DctM-like transporters; Region: DctM; pfam06808
335659003648	TRAP-type C4-dicarboxylate transport system, large permease component [Carbohydrate transport and metabolism]; Region: DctQ; cl17274
335659003649	glutathionine S-transferase; Provisional; Region: PRK10542
335659003650	GST_N family, Class Beta subfamily; GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of endogenous and xenobiotic alkylating agents, including carcinogens; Region: GST_N_Beta; cd03057
335659003651	C-terminal domain interface [polypeptide binding]; other site
335659003652	GSH binding site (G-site) [chemical binding]; other site
335659003653	dimer interface [polypeptide binding]; other site
335659003654	C-terminal, alpha helical domain of Class Beta Glutathione S-transferases; Region: GST_C_Beta; cd03188
335659003655	N-terminal domain interface [polypeptide binding]; other site
335659003656	dimer interface [polypeptide binding]; other site
335659003657	substrate binding pocket (H-site) [chemical binding]; other site
335659003658	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
335659003659	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
335659003660	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
335659003661	dimerization interface [polypeptide binding]; other site
335659003662	Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283
335659003663	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
335659003664	dimer interface [polypeptide binding]; other site
335659003665	putative CheW interface [polypeptide binding]; other site
335659003666	Putative glycerate dehydrogenase and related proteins of the D-specific 2-hydroxy dehydrogenase family; Region: GDH_like_2; cd12164
335659003667	Phosphoglycerate dehydrogenase and related dehydrogenases [Amino acid transport and metabolism]; Region: SerA; COG0111
335659003668	putative ligand binding site [chemical binding]; other site
335659003669	NAD binding site [chemical binding]; other site
335659003670	dimerization interface [polypeptide binding]; other site
335659003671	catalytic site [active]
335659003672	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3795
335659003673	Predicted RNA polymerase sigma factor containing a TPR repeat domain [Transcription]; Region: COG4941
335659003674	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
335659003675	Sigma-70, region 4; Region: Sigma70_r4_2; pfam08281
335659003676	DNA binding residues [nucleotide binding]
335659003677	Ligand-binding SRPBCC domain of an uncharacterized subfamily of proteins; Region: SRPBCC_1; cd07818
335659003678	putative hydrophobic ligand binding site [chemical binding]; other site
335659003679	Escherichia coli PhnB and similar proteins; the E. coli phnB gene is found next to an operon involved in the cleavage of carbon-phosphorus bonds in unactivated alkylphosphonates; Region: PhnB_like; cd06588
335659003680	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
335659003681	dimer interface [polypeptide binding]; other site
335659003682	3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK07231
335659003683	classical (c) SDRs; Region: SDR_c; cd05233
335659003684	NAD(P) binding site [chemical binding]; other site
335659003685	active site
335659003686	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
335659003687	PAS domain; Region: PAS_9; pfam13426
335659003688	putative active site [active]
335659003689	heme pocket [chemical binding]; other site
335659003690	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
335659003691	PAS domain; Region: PAS_9; pfam13426
335659003692	putative active site [active]
335659003693	heme pocket [chemical binding]; other site
335659003694	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
335659003695	PAS domain; Region: PAS_9; pfam13426
335659003696	putative active site [active]
335659003697	heme pocket [chemical binding]; other site
335659003698	Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283
335659003699	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
335659003700	dimer interface [polypeptide binding]; other site
335659003701	putative CheW interface [polypeptide binding]; other site
335659003702	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3795
335659003703	YCII-related domain; Region: YCII; cl00999
335659003704	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
335659003705	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
335659003706	WHG domain; Region: WHG; pfam13305
335659003707	Protein of unknown function (DUF2852); Region: DUF2852; pfam11014
335659003708	The Delta9 Fatty Acid Desaturase (Delta9-FADS)-like CD includes the delta-9 and delta-11 acyl CoA desaturases found in various eukaryotes including vertebrates, insects, higher plants, and fungi. The delta-9 acyl-lipid desaturases are found in a wide...; Region: Delta9-FADS-like; cd03505
335659003709	Fatty acid desaturase; Region: FA_desaturase; pfam00487
335659003710	Di-iron ligands [ion binding]; other site
335659003711	Serine acetyltransferase, N-terminal; Region: SATase_N; smart00971
335659003712	serine O-acetyltransferase; Region: cysE; TIGR01172
335659003713	Serine acetyltransferase (SAT): SAT catalyzes the CoA-dependent acetylation of the side chain hydroxyl group of L-serine to form O-acetylserine, as the first step of a two-step biosynthetic pathway in bacteria and plants leading to the formation of...; Region: LbH_SAT; cd03354
335659003714	trimer interface [polypeptide binding]; other site
335659003715	active site
335659003716	substrate binding site [chemical binding]; other site
335659003717	CoA binding site [chemical binding]; other site
335659003718	TolQ protein; Region: tolQ; TIGR02796
335659003719	Biopolymer transport protein [Intracellular trafficking and secretion]; Region: ExbD; COG0848
335659003720	TolR protein; Region: tolR; TIGR02801
335659003721	translocation protein TolB; Provisional; Region: tolB; PRK05137
335659003722	TolB amino-terminal domain; Region: TolB_N; pfam04052
335659003723	WD40-like Beta Propeller Repeat; Region: PD40; pfam07676
335659003724	WD40-like Beta Propeller Repeat; Region: PD40; pfam07676
335659003725	WD40-like Beta Propeller Repeat; Region: PD40; pfam07676
335659003726	PAS fold; Region: PAS_7; pfam12860
335659003727	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
335659003728	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
335659003729	metal binding site [ion binding]; metal-binding site
335659003730	active site
335659003731	I-site; other site
335659003732	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
335659003733	Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885
335659003734	Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185
335659003735	ligand binding site [chemical binding]; other site
335659003736	tol-pal system protein YbgF; Region: tol_pal_ybgF; TIGR02795
335659003737	N-terminal domain of predicted ATPase of the PP-loop faimly implicated in cell cycle control [Cell division and chromosome partitioning]. This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases...; Region: PP-ATPase; cd01992
335659003738	tRNA(Ile)-lysidine synthase MesJ [Cell cycle control, cell division, chromosome partitioning]; Region: MesJ; COG0037
335659003739	Ligand Binding Site [chemical binding]; other site
335659003740	FtsH Extracellular; Region: FtsH_ext; pfam06480
335659003741	ATP-dependent metalloprotease FtsH; Region: FtsH_fam; TIGR01241
335659003742	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
335659003743	Walker A motif; other site
335659003744	ATP binding site [chemical binding]; other site
335659003745	Walker B motif; other site
335659003746	arginine finger; other site
335659003747	Peptidase family M41; Region: Peptidase_M41; pfam01434
335659003748	Flp pilus assembly protein, pilin Flp [Intracellular trafficking and secretion]; Region: Flp; COG3847
335659003749	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
335659003750	pyruvate kinase; Provisional; Region: PRK06247
335659003751	Pyruvate kinase (PK):  Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl17342
335659003752	domain interfaces; other site
335659003753	active site
335659003754	Protein of unknown function (DUF1036); Region: DUF1036; pfam06282
335659003755	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3492
335659003756	hypothetical protein; Provisional; Region: PRK13694
335659003757	Domain of unknown function (DU1801); Region: DUF1801; cl17490
335659003758	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3108
335659003759	Peptidase M15; Region: Peptidase_M15_3; cl01194
335659003760	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2989
335659003761	Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471
335659003762	L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734
335659003763	L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734
335659003764	Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204
335659003765	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
335659003766	active site
335659003767	phosphorylation site [posttranslational modification]
335659003768	intermolecular recognition site; other site
335659003769	dimerization interface [polypeptide binding]; other site
335659003770	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
335659003771	Walker A motif; other site
335659003772	ATP binding site [chemical binding]; other site
335659003773	Walker B motif; other site
335659003774	arginine finger; other site
335659003775	Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954
335659003776	oligoendopeptidase, pepF/M3 family; Region: M3_fam_3; TIGR02290
335659003777	Peptidase family M3B Oligopeptidase F (PepF); Region: M3B_PepF_5; cd09610
335659003778	active site
335659003779	Zn binding site [ion binding]; other site
335659003780	Patatins and Phospholipases; Region: Patatin_and_cPLA2; cl11396
335659003781	active site
335659003782	nucleophile elbow; other site
335659003783	Bacterial aa3 type cytochrome c oxidase subunit IV; Region: COX4_pro_2; pfam07835
335659003784	Rubrum transdehydrogenase NAD-binding and catalytic domains; Region: Rubrum_tdh; cd05304
335659003785	NAD/NADP transhydrogenase alpha subunit [Energy production and conversion]; Region: PntA; COG3288
335659003786	ligand binding site [chemical binding]; other site
335659003787	homodimer interface [polypeptide binding]; other site
335659003788	NAD(P) binding site [chemical binding]; other site
335659003789	trimer interface B [polypeptide binding]; other site
335659003790	trimer interface A [polypeptide binding]; other site
335659003791	Domain of unknown function (DUF3814); Region: DUF3814; pfam12769
335659003792	NAD/NADP transhydrogenase beta subunit [Energy production and conversion]; Region: PntB; COG1282
335659003793	NAD(P) transhydrogenase beta subunit; Region: PNTB; pfam02233
335659003794	Partial alpha/beta-hydrolase lipase region; Region: Abhydro_lipase; pfam04083
335659003795	Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695
335659003796	Ca2+/H+ antiporter [Inorganic ion transport and metabolism]; Region: ChaA; COG0387
335659003797	Cupin domain; Region: Cupin_2; cl17218
335659003798	TPR repeat; Region: TPR_11; pfam13414
335659003799	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
335659003800	binding surface
335659003801	TPR motif; other site
335659003802	TPR repeat; Region: TPR_11; pfam13414
335659003803	30S ribosomal protein S21; Reviewed; Region: rpsU; PRK00270
335659003804	Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane channels that selectively transport water, small neutral molecules, and ions out of and between cells. The channel proteins share a common fold: the N-terminal...; Region: MIP; cd00333
335659003805	amphipathic channel; other site
335659003806	Asn-Pro-Ala signature motifs; other site
335659003807	phosphoribosylaminoimidazole carboxylase ATPase subunit; Reviewed; Region: PRK06019
335659003808	ATP-grasp domain; Region: ATP-grasp; pfam02222
335659003809	AIR carboxylase; Region: AIRC; cl00310
335659003810	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
335659003811	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
335659003812	metal binding site [ion binding]; metal-binding site
335659003813	active site
335659003814	I-site; other site
335659003815	Uncharacterized conserved small protein containing a coiled-coil domain [Function unknown]; Region: COG5481
335659003816	Protein of unknown function (DUF465); Region: DUF465; cl01070
335659003817	Predicted dehydrogenase [General function prediction only]; Region: COG0579
335659003818	hydroxyglutarate oxidase; Provisional; Region: PRK11728
335659003819	PAS fold; Region: PAS_7; pfam12860
335659003820	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
335659003821	putative active site [active]
335659003822	FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202
335659003823	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
335659003824	putative active site [active]
335659003825	heme pocket [chemical binding]; other site
335659003826	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
335659003827	putative active site [active]
335659003828	heme pocket [chemical binding]; other site
335659003829	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
335659003830	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
335659003831	metal binding site [ion binding]; metal-binding site
335659003832	active site
335659003833	I-site; other site
335659003834	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
335659003835	glycerol-3-phosphate dehydrogenase; Provisional; Region: PRK13369
335659003836	putative FAD-binding dehydrogenase; Reviewed; Region: PRK12834
335659003837	ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842
335659003838	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
335659003839	Walker A/P-loop; other site
335659003840	ATP binding site [chemical binding]; other site
335659003841	Q-loop/lid; other site
335659003842	ABC transporter signature motif; other site
335659003843	Walker B; other site
335659003844	D-loop; other site
335659003845	H-loop/switch region; other site
335659003846	TOBE domain; Region: TOBE_2; pfam08402
335659003847	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
335659003848	dimer interface [polypeptide binding]; other site
335659003849	conserved gate region; other site
335659003850	putative PBP binding loops; other site
335659003851	ABC-ATPase subunit interface; other site
335659003852	ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177
335659003853	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
335659003854	dimer interface [polypeptide binding]; other site
335659003855	conserved gate region; other site
335659003856	putative PBP binding loops; other site
335659003857	ABC-ATPase subunit interface; other site
335659003858	ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395
335659003859	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
335659003860	dimer interface [polypeptide binding]; other site
335659003861	conserved gate region; other site
335659003862	putative PBP binding loops; other site
335659003863	ABC-ATPase subunit interface; other site
335659003864	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
335659003865	dimer interface [polypeptide binding]; other site
335659003866	conserved gate region; other site
335659003867	putative PBP binding loops; other site
335659003868	ABC-ATPase subunit interface; other site
335659003869	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653
335659003870	Uncharacterized protein involved in outer membrane biogenesis [Cell envelope biogenesis, outer membrane]; Region: AsmA; COG2982
335659003871	Type II secretion system (T2SS), protein N; Region: T2SN; pfam01203
335659003872	AsmA-like C-terminal region; Region: AsmA_2; pfam13502
335659003873	Acyl CoA:acetate/3-ketoacid CoA transferase, alpha subunit [Lipid metabolism]; Region: AtoD; COG1788
335659003874	3-oxoacid CoA-transferase, B subunit; Region: pcaJ_scoB_fam; TIGR02428
335659003875	Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; pfam03781
335659003876	Uncharacterized conserved protein [Function unknown]; Region: COG1262
335659003877	nitrite reductase, copper-containing; Region: Cu_nitrite_red; TIGR02376
335659003878	Multicopper oxidase; Region: Cu-oxidase_3; pfam07732
335659003879	Multicopper oxidase; Region: Cu-oxidase; pfam00394
335659003880	coproporphyrinogen III oxidase; Provisional; Region: PRK09249
335659003881	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
335659003882	FeS/SAM binding site; other site
335659003883	HemN C-terminal domain; Region: HemN_C; pfam06969
335659003884	hybrid cluster protein-associated redox disulfide domain; Region: prismane_assoc; TIGR03980
335659003885	cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664
335659003886	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
335659003887	ligand binding site [chemical binding]; other site
335659003888	flexible hinge region; other site
335659003889	helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092
335659003890	putative switch regulator; other site
335659003891	non-specific DNA interactions [nucleotide binding]; other site
335659003892	DNA binding site [nucleotide binding]
335659003893	sequence specific DNA binding site [nucleotide binding]; other site
335659003894	putative cAMP binding site [chemical binding]; other site
335659003895	NnrS protein; Region: NnrS; pfam05940
335659003896	Arabinose-binding domain of AraC transcription regulator, N-term; Region: Arabinose_bd; pfam12625
335659003897	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
335659003898	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
335659003899	Response regulator [Signal transduction mechanisms]; Region: TtrR; COG4566
335659003900	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
335659003901	active site
335659003902	intermolecular recognition site; other site
335659003903	dimerization interface [polypeptide binding]; other site
335659003904	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
335659003905	DNA binding residues [nucleotide binding]
335659003906	dimerization interface [polypeptide binding]; other site
335659003907	conserved hypothetical protein; Region: TIGR02231
335659003908	N-terminal domain of unknown function (DUF4140); Region: DUF4140; pfam13600
335659003909	Domain of unknown function (DUF4139); Region: DUF4139; pfam13598
335659003910	hemin importer ATP-binding subunit; Provisional; Region: hmuV; PRK13548
335659003911	ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214
335659003912	Walker A/P-loop; other site
335659003913	ATP binding site [chemical binding]; other site
335659003914	Q-loop/lid; other site
335659003915	ABC transporter signature motif; other site
335659003916	Walker B; other site
335659003917	D-loop; other site
335659003918	H-loop/switch region; other site
335659003919	iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577
335659003920	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550
335659003921	ABC-ATPase subunit  interface; other site
335659003922	dimer interface [polypeptide binding]; other site
335659003923	putative PBP binding regions; other site
335659003924	ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614
335659003925	Hemin binding protein HutB.  These proteins have been shown to function as initial receptors in ABC transport of hemin and hemoproteins in many eubacterial species.  They belong to the TroA superfamily of periplasmic metal binding proteins that share a...; Region: HutB; cd01149
335659003926	putative hemin binding site; other site
335659003927	Hemin uptake protein hemP; Region: hemP; pfam10636
335659003928	TonB-dependent heme/hemoglobin receptor family protein; Region: TonB-hemin; TIGR01785
335659003929	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
335659003930	N-terminal plug; other site
335659003931	ligand-binding site [chemical binding]; other site
335659003932	Uncharacterized enzyme involved in biosynthesis of extracellular polysaccharides [General function prediction only]; Region: COG2329
335659003933	putative heme utilization carrier protein HutX; Region: HutX; TIGR04108
335659003934	tonB-system energizer ExbB; Region: exbB; TIGR02797
335659003935	Biopolymer transport protein [Intracellular trafficking and secretion]; Region: ExbD; COG0848
335659003936	TonB system transport protein ExbD, group 1; Region: ExbD_1; TIGR02803
335659003937	Periplasmic protein TonB, links inner and outer membranes [Cell envelope biogenesis, outer membrane]; Region: TonB; COG0810
335659003938	TonB family C-terminal domain; Region: tonB_Cterm; TIGR01352
335659003939	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4222
335659003940	Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596
335659003941	Putative lysophospholipase; Region: Hydrolase_4; pfam12146
335659003942	Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849
335659003943	ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395
335659003944	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
335659003945	dimer interface [polypeptide binding]; other site
335659003946	conserved gate region; other site
335659003947	putative PBP binding loops; other site
335659003948	ABC-ATPase subunit interface; other site
335659003949	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
335659003950	dimer interface [polypeptide binding]; other site
335659003951	conserved gate region; other site
335659003952	putative PBP binding loops; other site
335659003953	ABC-ATPase subunit interface; other site
335659003954	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547
335659003955	Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416
335659003956	C-terminal binding protein (CtBP), D-isomer-specific 2-hydroxyacid dehydrogenases related repressor; Region: CtBP_dh; cd05299
335659003957	Lactate dehydrogenase and related dehydrogenases [Energy production and conversion / Coenzyme metabolism / General function prediction only]; Region: LdhA; COG1052
335659003958	ligand binding site [chemical binding]; other site
335659003959	NAD binding site [chemical binding]; other site
335659003960	catalytic site [active]
335659003961	Cache is an extracellular domain that is predicted to have a role in small-molecule recognition in a wide range of proteins; Region: Cache_2; smart01049
335659003962	HAMP domain; Region: HAMP; pfam00672
335659003963	Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283
335659003964	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
335659003965	dimer interface [polypeptide binding]; other site
335659003966	putative CheW interface [polypeptide binding]; other site
335659003967	Tripartite tricarboxylate transporter family receptor; Region: TctC; cl17792
335659003968	EamA-like transporter family; Region: EamA; pfam00892
335659003969	Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950
335659003970	EamA-like transporter family; Region: EamA; pfam00892
335659003971	Protein of unknown function (DUF1330); Region: DUF1330; cl02288
335659003972	Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697
335659003973	EamA-like transporter family; Region: EamA; pfam00892
335659003974	EamA-like transporter family; Region: EamA; pfam00892
335659003975	magnesium-translocating P-type ATPase; Region: ATPase-IIIB_Mg; TIGR01524
335659003976	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
335659003977	Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246
335659003978	Soluble P-type ATPase [General function prediction only]; Region: COG4087
335659003979	Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689
335659003980	LTXXQ motif family protein; Region: LTXXQ; pfam07813
335659003981	RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730
335659003982	The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850
335659003983	HlyD family secretion protein; Region: HlyD_3; pfam13437
335659003984	ABC-type transport system, involved in lipoprotein release, permease component [Cell envelope biogenesis, outer membrane]; Region: LolE; COG4591
335659003985	MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
335659003986	FtsX-like permease family; Region: FtsX; pfam02687
335659003987	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
335659003988	ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255
335659003989	Walker A/P-loop; other site
335659003990	ATP binding site [chemical binding]; other site
335659003991	Q-loop/lid; other site
335659003992	ABC transporter signature motif; other site
335659003993	Walker B; other site
335659003994	D-loop; other site
335659003995	H-loop/switch region; other site
335659003996	Adenylosuccinate synthetase; Region: Adenylsucc_synt; smart00788
335659003997	Adenylosuccinate synthetase (AdSS) catalyzes the first step in the de novo biosynthesis of AMP. IMP and L-aspartate are conjugated in a two-step reaction accompanied by the hydrolysis of GTP to GDP in the presence of Mg2+. In the first step, the...; Region: AdSS; cd03108
335659003998	GDP-binding site [chemical binding]; other site
335659003999	ACT binding site; other site
335659004000	IMP binding site; other site
335659004001	Domain of unknown function (DUF4112); Region: DUF4112; pfam13430
335659004002	methionine sulfoxide reductase B; Provisional; Region: PRK00222
335659004003	SelR domain; Region: SelR; pfam01641
335659004004	methionine sulfoxide reductase A; Provisional; Region: PRK13014
335659004005	TPR repeat; Region: TPR_11; pfam13414
335659004006	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
335659004007	binding surface
335659004008	TPR motif; other site
335659004009	TPR repeat; Region: TPR_11; pfam13414
335659004010	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
335659004011	binding surface
335659004012	TPR motif; other site
335659004013	TPR repeat; Region: TPR_11; pfam13414
335659004014	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
335659004015	TPR repeat; Region: TPR_11; pfam13414
335659004016	binding surface
335659004017	TPR motif; other site
335659004018	TPR repeat; Region: TPR_11; pfam13414
335659004019	Caspase domain; Region: Peptidase_C14; pfam00656
335659004020	ATP-dependent exoDNAse (exonuclease V), alpha subunit - helicase superfamily I member [DNA replication, recombination, and repair]; Region: RecD; COG0507
335659004021	AAA domain; Region: AAA_30; pfam13604
335659004022	Family description; Region: UvrD_C_2; pfam13538
335659004023	periplasmic nitrate (or nitrite) reductase c-type cytochrome, NapC/NirT family; Region: napC_nirT; TIGR02161
335659004024	NapC/NirT cytochrome c family, N-terminal region; Region: Cytochrom_NNT; pfam03264
335659004025	Nitrate reductase cytochrome c-type subunit (NapB); Region: NapB; pfam03892
335659004026	nitrate reductase catalytic subunit; Provisional; Region: PRK13532
335659004027	Nitrate reductases, NapA (Nitrate-R-NapA), NasA, and NarB catalyze the reduction of nitrate to nitrite. Monomeric Nas is located in the cytoplasm and participates in nitrogen assimilation. Dimeric Nap is located in the periplasm and is coupled to quinol...; Region: MopB_Nitrate-R-NapA-like; cd02754
335659004028	[4Fe-4S] binding site [ion binding]; other site
335659004029	molybdopterin cofactor binding site; other site
335659004030	Nitrate reductases, NapA (Nitrate-R-NapA), NasA, and NarB catalyze the reduction of nitrate to nitrite. Monomeric Nas is located in the cytoplasm and participates in nitrogen assimilation. Dimeric Nap is located in the periplasm and is coupled to quinol...; Region: MopB_CT_Nitrate-R-NapA-like; cd02791
335659004031	molybdopterin cofactor binding site; other site
335659004032	NapD protein; Region: NapD; pfam03927
335659004033	Periplasmic nitrate reductase protein NapE; Region: NapE; pfam06796
335659004034	probable oxidoreductase, LLM family; Region: LLM_2I7G; TIGR03858
335659004035	Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases [Energy production and conversion]; Region: COG2141
335659004036	Uncharacterized protein conserved in bacteria (DUF2200); Region: DUF2200; pfam09966
335659004037	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
335659004038	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
335659004039	DNA binding residues [nucleotide binding]
335659004040	dimerization interface [polypeptide binding]; other site
335659004041	Outer membrane protein beta-barrel domain; Region: OMP_b-brl; pfam13505
335659004042	Legionella pneumophila major outer membrane protein precursor; Region: Legionella_OMP; pfam05150
335659004043	Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124
335659004044	Cytochrome P450; Region: p450; cl12078
335659004045	ABC transporter, substrate-binding protein, aliphatic sulfonates family; Region: SsuA_fam; TIGR01728
335659004046	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
335659004047	substrate binding pocket [chemical binding]; other site
335659004048	membrane-bound complex binding site; other site
335659004049	hinge residues; other site
335659004050	alkanesulfonate monooxygenase; Provisional; Region: PRK00719
335659004051	Alkanesulfonate monoxygenase is the monoxygenase of a two-component system that catalyzes the conversion of alkanesulfonates to the corresponding aldehyde and sulfite. Alkanesulfonate monoxygenase (SsuD) has an absolute requirement for reduced flavin...; Region: Alkanesulfonate_monoxygenase; cd01094
335659004052	active site
335659004053	dimer interface [polypeptide binding]; other site
335659004054	non-prolyl cis peptide bond; other site
335659004055	insertion regions; other site
335659004056	ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600
335659004057	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
335659004058	dimer interface [polypeptide binding]; other site
335659004059	conserved gate region; other site
335659004060	putative PBP binding loops; other site
335659004061	ABC-ATPase subunit interface; other site
335659004062	aliphatic sulfonates transport ATP-binding subunit; Provisional; Region: ssuB; PRK11247
335659004063	ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293
335659004064	Walker A/P-loop; other site
335659004065	ATP binding site [chemical binding]; other site
335659004066	Q-loop/lid; other site
335659004067	ABC transporter signature motif; other site
335659004068	Walker B; other site
335659004069	D-loop; other site
335659004070	H-loop/switch region; other site
335659004071	Flavin reductase like domain; Region: Flavin_Reduct; smart00903
335659004072	hypothetical protein; Provisional; Region: PRK07338
335659004073	M20 Peptidase Glutamate carboxypeptidase, a periplasmic enzyme; Region: M20_CPDG2; cd03885
335659004074	metal binding site [ion binding]; metal-binding site
335659004075	dimer interface [polypeptide binding]; other site
335659004076	PAP2, haloperoxidase_like subfamily. Haloperoxidases catalyze the oxidation of halides such as bromide or chloride by hydrogen peroxide, which results in subsequent halogenation of organic substrates, or halide-assisted disproportionation of hydrogen...; Region: PAP2_haloperoxidase; cd03398
335659004077	active site
335659004078	GYD domain; Region: GYD; cl01743
335659004079	Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204
335659004080	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
335659004081	Walker A motif; other site
335659004082	ATP binding site [chemical binding]; other site
335659004083	Walker B motif; other site
335659004084	arginine finger; other site
335659004085	Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954
335659004086	flagellar motor switch protein; Reviewed; Region: PRK08916
335659004087	flagellar assembly protein H; Validated; Region: fliH; PRK06032
335659004088	Flagellar assembly protein FliH; Region: FliH; pfam02108
335659004089	flagellar motor switch protein G; Validated; Region: fliG; PRK05686
335659004090	MgtE intracellular N domain; Region: MgtE_N; cl15244
335659004091	FliG C-terminal domain; Region: FliG_C; pfam01706
335659004092	flagellar MS-ring protein; Reviewed; Region: fliF; PRK06007
335659004093	Secretory protein of YscJ/FliF family; Region: YscJ_FliF; cl01907
335659004094	Flagellar M-ring protein C-terminal; Region: YscJ_FliF_C; pfam08345
335659004095	Protein of unknown function (DUF1153); Region: DUF1153; pfam06627
335659004096	Flagellar hook capping protein - N-terminal region; Region: FlgD; pfam03963
335659004097	FlgD Tudor-like domain; Region: FLgD_tudor; pfam13861
335659004098	Flagellar hook-length control protein FliK; Region: Flg_hook; pfam02120
335659004099	Predicted tRNA(5-methylaminomethyl-2-thiouridylate) methyltransferase, contains the PP-loop ATPase domain [Translation, ribosomal structure and biogenesis]; Region: TrmU; COG0482
335659004100	tRNA methyl transferase. This family represents tRNA(5-methylaminomethyl-2-thiouridine)-methyltransferase which is involved in the biosynthesis of the modified nucleoside 5-methylaminomethyl-2-thiouridine present in the wobble position of some tRNAs; Region: tRNA_Me_trans; cd01998
335659004101	Ligand Binding Site [chemical binding]; other site
335659004102	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
335659004103	S-adenosylmethionine binding site [chemical binding]; other site
335659004104	Nitrate reductase delta subunit; Region: Nitrate_red_del; pfam02613
335659004105	Protein of unknown function (DUF3306); Region: DUF3306; pfam11748
335659004106	Protein of unknown function (DUF3305); Region: DUF3305; pfam11749
335659004107	4Fe-4S dicluster domain; Region: Fer4_7; pfam12838
335659004108	4Fe-4S binding domain; Region: Fer4_6; pfam12837
335659004109	4Fe-4S dicluster domain; Region: Fer4_7; pfam12838
335659004110	Cytochrome b (N-terminus)/b6/petB:  Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria; Region: Cytochrome_b_N; cl00859
335659004111	formate dehydrogenase, gamma subunit; Region: formate-DH-gamm; TIGR01583
335659004112	DMSO reductase, iron-sulfur subunit; Region: DMSO_dmsB; TIGR02951
335659004113	Formate dehydrogenase N, alpha subunit (Formate-Dh-Na) is a major component of nitrate respiration in bacteria such as in the E. coli formate dehydrogenase N (Fdh-N). Fdh-N is a membrane protein that is a complex of three different subunits and is the...; Region: MopB_Formate-Dh-Na-like; cd02752
335659004114	formate dehydrogenase, alpha subunit, archaeal-type; Region: Fdh-alpha; TIGR01591
335659004115	[4Fe-4S] binding site [ion binding]; other site
335659004116	molybdopterin cofactor binding site; other site
335659004117	Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a  large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928
335659004118	Formate dehydrogenase N, alpha subunit (Formate-Dh-Na) is a major component of nitrate respiration in bacteria such as in the E. coli formate dehydrogenase N (Fdh-N). Fdh-N is a membrane protein that is a complex of three different subunits and is the...; Region: MopB_CT_Formate-Dh-Na-like; cd02792
335659004119	molybdopterin cofactor binding site; other site
335659004120	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
335659004121	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
335659004122	active site
335659004123	phosphorylation site [posttranslational modification]
335659004124	intermolecular recognition site; other site
335659004125	dimerization interface [polypeptide binding]; other site
335659004126	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
335659004127	DNA binding site [nucleotide binding]
335659004128	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
335659004129	dimer interface [polypeptide binding]; other site
335659004130	phosphorylation site [posttranslational modification]
335659004131	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
335659004132	ATP binding site [chemical binding]; other site
335659004133	Mg2+ binding site [ion binding]; other site
335659004134	G-X-G motif; other site
335659004135	alternative sigma factor RpoH; Region: rpoH_proteo; TIGR02392
335659004136	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
335659004137	Sigma-70, region 4; Region: Sigma70_r4; pfam04545
335659004138	Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841
335659004139	RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730
335659004140	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
335659004141	HlyD family secretion protein; Region: HlyD_3; pfam13437
335659004142	Catalase-like heme-binding proteins similar to the uncharacterized srpA; Region: srpA_like; cd08153
335659004143	putative heme binding pocket [chemical binding]; other site
335659004144	Cytochrome B561 [Energy production and conversion]; Region: CybB; COG3038
335659004145	formate dehydrogenase accessory protein; Reviewed; Region: PRK00724
335659004146	Protein of unknown function (DUF1275); Region: DUF1275; pfam06912
335659004147	Bacterial Cytochrome Ubiquinol Oxidase; Region: Bac_Ubq_Cox; pfam01654
335659004148	cytochrome d ubiquinol oxidase subunit 2; Provisional; Region: PRK15003; cl12219
335659004149	Cytochrome oxidase subunit II; Region: Cyto_ox_2; pfam02322
335659004150	bicupin, oxalate decarboxylase family; Region: bicupin_oxalic; TIGR03404
335659004151	Cupin; Region: Cupin_1; smart00835
335659004152	Cupin; Region: Cupin_1; smart00835
335659004153	oxidoreductase alpha (molybdopterin) subunit; Region: Fdhalpha-like; TIGR01701
335659004154	The MopB_ydeP CD includes a group of related uncharacterized bacterial molybdopterin-binding oxidoreductase-like domains with a putative molybdopterin cofactor binding site. These members belong to the molybdopterin_binding (MopB) superfamily of proteins; Region: MopB_ydeP; cd02767
335659004155	putative molybdopterin cofactor binding site [chemical binding]; other site
335659004156	The MopB_CT_ydeP CD includes a group of related uncharacterized bacterial molybdopterin-binding oxidoreductase-like domains with a putative molybdopterin cofactor binding site. This CD is of the conserved molybdopterin_binding C-terminal (MopB_CT) region...; Region: MopB_CT_ydeP; cd02787
335659004157	putative molybdopterin cofactor binding site; other site
335659004158	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
335659004159	PAS fold; Region: PAS_3; pfam08447
335659004160	putative active site [active]
335659004161	heme pocket [chemical binding]; other site
335659004162	PAS domain; Region: PAS_9; pfam13426
335659004163	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
335659004164	putative active site [active]
335659004165	heme pocket [chemical binding]; other site
335659004166	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
335659004167	ATP binding site [chemical binding]; other site
335659004168	Mg2+ binding site [ion binding]; other site
335659004169	G-X-G motif; other site
335659004170	The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cd03440
335659004171	active site 2 [active]
335659004172	active site 1 [active]
335659004173	multidrug efflux system subunit MdtB; Provisional; Region: PRK10503
335659004174	RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730
335659004175	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
335659004176	methyl indole-3-acetate methyltransferase; Region: PLN02211; cl17657
335659004177	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
335659004178	malonate decarboxylase, alpha subunit; Region: mdcA; TIGR01110
335659004179	Coenzyme A transferase; Region: CoA_trans; cl17247
335659004180	malonate decarboxylase subunit delta; Provisional; Region: PRK02103
335659004181	malonate decarboxylase subunit beta; Reviewed; Region: PRK07189
335659004182	malonate decarboxylase, gamma subunit; Region: malonate_gamma; TIGR03134
335659004183	phosphoribosyl-dephospho-CoA transferase; Provisional; Region: PRK02098
335659004184	Phosphoribosyl-dephospho-CoA transferase MdcG; Region: MdcG; pfam10620
335659004185	triphosphoribosyl-dephospho-CoA synthase MdcB; Region: malonate_mdcB; TIGR03132
335659004186	Membrane transport protein; Region: Mem_trans; pfam03547
335659004187	malonate decarboxylase, epsilon subunit; Region: malonate_mdcH; TIGR03131
335659004188	Multidrug resistance efflux pump [Defense mechanisms]; Region: EmrA; COG1566
335659004189	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
335659004190	HlyD family secretion protein; Region: HlyD_3; pfam13437
335659004191	Fusaric acid resistance protein family; Region: FUSC; pfam04632
335659004192	Response regulator receiver domain; Region: Response_reg; pfam00072
335659004193	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
335659004194	active site
335659004195	phosphorylation site [posttranslational modification]
335659004196	intermolecular recognition site; other site
335659004197	dimerization interface [polypeptide binding]; other site
335659004198	Response regulator [Signal transduction mechanisms]; Region: TtrR; COG4566
335659004199	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
335659004200	active site
335659004201	phosphorylation site [posttranslational modification]
335659004202	intermolecular recognition site; other site
335659004203	dimerization interface [polypeptide binding]; other site
335659004204	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
335659004205	DNA binding residues [nucleotide binding]
335659004206	dimerization interface [polypeptide binding]; other site
335659004207	PAS fold; Region: PAS; pfam00989
335659004208	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
335659004209	putative active site [active]
335659004210	heme pocket [chemical binding]; other site
335659004211	PAS domain; Region: PAS_9; pfam13426
335659004212	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
335659004213	dimer interface [polypeptide binding]; other site
335659004214	phosphorylation site [posttranslational modification]
335659004215	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
335659004216	ATP binding site [chemical binding]; other site
335659004217	G-X-G motif; other site
335659004218	AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207
335659004219	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
335659004220	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
335659004221	ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747
335659004222	The substrate-binding component of ABC-type thermophilic oligopeptide-binding protein Hb8-like import systems, contains the type 2 periplasmic binding fold; Region: PBP2_thermophilic_Hb8_like; cd08513
335659004223	peptide binding site [polypeptide binding]; other site
335659004224	dimer interface [polypeptide binding]; other site
335659004225	ABC-type metal ion transport system, periplasmic component/surface antigen [Inorganic ion transport and metabolism]; Region: NlpA; COG1464
335659004226	NLPA lipoprotein; Region: Lipoprotein_9; pfam03180
335659004227	putative FMN-dependent luciferase-like monooxygenase, KPN_01858 family; Region: LLM_KPN_01858; TIGR04027
335659004228	probable oxidoreductase, LLM family; Region: LLM_2I7G; TIGR03858
335659004229	CMD domain protein, Avi_7170 family; Region: CMD_Avi_7170; TIGR04029
335659004230	alkylhydroperoxidase domain protein, Avi_7169 family; Region: perox_Avi_7169; TIGR04030
335659004231	uncharacterized peroxidase-related enzyme; Region: peroxid_rel; TIGR01926
335659004232	ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683
335659004233	Type I periplasmic ligand-binding domain of uncharacterized ABC (Atpase Binding Cassette)-type active transport systems; Region: PBP1_ABC_ligand_binding_like_14; cd06349
335659004234	putative ligand binding site [chemical binding]; other site
335659004235	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
335659004236	Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582
335659004237	TM-ABC transporter signature motif; other site
335659004238	ABC-type branched-chain amino acid transport system, permease component [Amino acid transport and metabolism]; Region: LivM; COG4177
335659004239	Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581
335659004240	TM-ABC transporter signature motif; other site
335659004241	ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411
335659004242	ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219
335659004243	Walker A/P-loop; other site
335659004244	ATP binding site [chemical binding]; other site
335659004245	Q-loop/lid; other site
335659004246	ABC transporter signature motif; other site
335659004247	Walker B; other site
335659004248	D-loop; other site
335659004249	H-loop/switch region; other site
335659004250	ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410
335659004251	ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224
335659004252	Walker A/P-loop; other site
335659004253	ATP binding site [chemical binding]; other site
335659004254	Q-loop/lid; other site
335659004255	ABC transporter signature motif; other site
335659004256	Walker B; other site
335659004257	D-loop; other site
335659004258	H-loop/switch region; other site
335659004259	high-affinity nickel-transporter, HoxN/HupN/NixA family; Region: nico; TIGR00802
335659004260	Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629
335659004261	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244
335659004262	HerA helicase [Replication, recombination, and repair]; Region: COG0433
335659004263	Domain of unknown function DUF87; Region: DUF87; pfam01935
335659004264	Flagellin N-methylase; Region: FliB; cl00497
335659004265	Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280
335659004266	Ketopantoate reductase PanE/ApbA; Region: ApbA; pfam02558
335659004267	helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347
335659004268	MarR family; Region: MarR; pfam01047
335659004269	Porin subfamily; Region: Porin_2; pfam02530
335659004270	Transcriptional regulators [Transcription]; Region: MarR; COG1846
335659004271	MarR family; Region: MarR_2; cl17246
335659004272	flagellum-specific ATP synthase; Validated; Region: fliI; PRK06002
335659004273	RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233
335659004274	Walker A motif; other site
335659004275	ATP binding site [chemical binding]; other site
335659004276	Walker B motif; other site
335659004277	flagellar basal body rod protein FlgF; Reviewed; Region: flgF; PRK12642
335659004278	Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460
335659004279	flagellar basal-body rod protein FlgF; Region: flgF; TIGR02490
335659004280	Protein of unknown function (DUF1217); Region: DUF1217; pfam06748
335659004281	Protein of unknown function (DUF1217); Region: DUF1217; pfam06748
335659004282	Flagellar motor component [Cell motility and secretion]; Region: MotA; COG1291
335659004283	flagellar motor protein MotA; Validated; Region: PRK09110
335659004284	Flagellar motor switch protein [Cell motility and secretion]; Region: FliM; COG1868
335659004285	Surface presentation of antigens (SPOA); Region: SpoA; pfam01052
335659004286	Surface presentation of antigens (SPOA); Region: SpoA; cl00819
335659004287	flagellar motor switch protein G; Validated; Region: fliG; PRK05686
335659004288	FliG C-terminal domain; Region: FliG_C; pfam01706
335659004289	flagellar biosynthesis protein FlhB; Reviewed; Region: flhB; PRK13109
335659004290	Uncharacterized homolog of the cytoplasmic domain of flagellar protein FhlB [Function unknown]; Region: COG2257; cl15822
335659004291	flagellar basal body rod protein FlgB; Reviewed; Region: flgB; PRK06003
335659004292	Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460
335659004293	flagellar basal body rod protein FlgC; Reviewed; Region: flgC; PRK12782
335659004294	Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429
335659004295	flagellar hook-basal body protein FliE; Reviewed; Region: fliE; PRK00790
335659004296	flagellar basal body rod protein FlgG; Reviewed; Region: flgG; PRK12692
335659004297	Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429
335659004298	SAF domains of the flagella basal body P-ring formation protein FlgA and the flp pilus assembly CpaB; Region: SAF_CpaB_FlgA_like; cd11614
335659004299	Domains similar to fish antifreeze type III protein; Region: SAF; cl00555
335659004300	Flagellar P-ring protein; Region: FlgI; pfam02119
335659004301	flagellar basal body P-ring protein; Reviewed; Region: flgI; PRK12789
335659004302	Uncharacterized conserved protein [Function unknown]; Region: COG3334
335659004303	flagellar basal body L-ring protein; Reviewed; Region: flgH; PRK00249
335659004304	flagellar basal body L-ring protein; Reviewed; Region: flgH; PRK12788
335659004305	Flagellar basal body-associated protein FliL; Region: FliL; pfam03748
335659004306	FliP family; Region: FliP; cl00593
335659004307	flagellin; Reviewed; Region: PRK12687
335659004308	Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669
335659004309	Bacterial flagellin C-terminal helical region; Region: Flagellin_C; pfam00700
335659004310	flagellin; Reviewed; Region: PRK12687
335659004311	Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669
335659004312	Bacterial flagellin C-terminal helical region; Region: Flagellin_C; pfam00700
335659004313	flagellin; Reviewed; Region: PRK12687
335659004314	Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669
335659004315	Bacterial flagellin C-terminal helical region; Region: Flagellin_C; pfam00700
335659004316	flagellar MS-ring protein; Reviewed; Region: fliF; PRK06007
335659004317	Secretory protein of YscJ/FliF family; Region: YscJ_FliF; pfam01514
335659004318	Flagellar M-ring protein C-terminal; Region: YscJ_FliF_C; pfam08345
335659004319	flagellar motor protein MotB; Validated; Region: motB; PRK05996
335659004320	Membrane MotB of proton-channel complex MotA/MotB; Region: MotB_plug; pfam13677
335659004321	Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185
335659004322	ligand binding site [chemical binding]; other site
335659004323	chemotaxis protein; Reviewed; Region: PRK12798
335659004324	Flagellar hook-length control protein FliK; Region: Flg_hook; pfam02120
335659004325	Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741
335659004326	Lytic Transglycosylase (LT)  and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL).  LTs...; Region: LT_GEWL; cd00254
335659004327	N-acetyl-D-glucosamine binding site [chemical binding]; other site
335659004328	flagellar hook protein FlgE; Validated; Region: flgE; PRK05682
335659004329	Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460
335659004330	Flagellar basal body protein FlaE; Region: FlaE; pfam07559
335659004331	Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; cl15855
335659004332	Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429
335659004333	flagellar hook-associated protein FlgK; Validated; Region: flgK; PRK07521
335659004334	Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429
335659004335	flagellar hook-associated protein FlgL; Validated; Region: flgL; PRK06008
335659004336	Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669
335659004337	Bacterial flagellin C-terminal helical region; Region: Flagellin_C; pfam00700
335659004338	Flagellar protein FlaF; Region: FlaF; pfam07309
335659004339	flagellar biosynthesis regulatory protein FlaF; Reviewed; Region: flaF; PRK12793
335659004340	flagellar biosynthesis repressor FlbT; Reviewed; Region: flbT; PRK00794
335659004341	flagellar basal body rod modification protein; Reviewed; Region: flgD; PRK06009
335659004342	Flagellar hook capping protein - N-terminal region; Region: FlgD; pfam03963
335659004343	flagellar biosynthesis protein FliQ; Reviewed; Region: fliQ; PRK12781
335659004344	flagellar biosynthesis protein FlhA; Reviewed; Region: flhA; PRK12792
335659004345	FHIPEP family; Region: FHIPEP; pfam00771
335659004346	flagellar biosynthesis protein FliR; Reviewed; Region: fliR; PRK12780
335659004347	Rod binding protein; Region: Rod-binding; pfam10135
335659004348	Alpha amylase catalytic domain family; Region: AmyAc_family; cl07893
335659004349	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
335659004350	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
335659004351	DNA binding site [nucleotide binding]
335659004352	Transcriptional regulators [Transcription]; Region: MarR; COG1846
335659004353	MarR family; Region: MarR_2; cl17246
335659004354	Dienelactone hydrolase family; Region: DLH; pfam01738
335659004355	Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326
335659004356	Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680
335659004357	Beta-lactamase; Region: Beta-lactamase; pfam00144
335659004358	Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451
335659004359	atypical (a) SDRs, subgroup 4; Region: SDR_a4; cd05266
335659004360	putative NAD(P) binding site [chemical binding]; other site
335659004361	Predicted phosphatase/phosphohexomutase [General function prediction only]; Region: COG0637
335659004362	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
335659004363	motif II; other site
335659004364	SnoaL-like domain; Region: SnoaL_3; pfam13474
335659004365	SnoaL-like domain; Region: SnoaL_4; cl17707
335659004366	Mannitol-1-phosphate/altronate dehydrogenases [Carbohydrate transport and metabolism]; Region: MtlD; COG0246
335659004367	Mannitol dehydrogenase Rossmann domain; Region: Mannitol_dh; pfam01232
335659004368	Mannitol dehydrogenase C-terminal domain; Region: Mannitol_dh_C; pfam08125
335659004369	Transcriptional regulators [Transcription]; Region: FadR; COG2186
335659004370	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
335659004371	DNA-binding site [nucleotide binding]; DNA binding site
335659004372	FCD domain; Region: FCD; pfam07729
335659004373	TRAP-type C4-dicarboxylate transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: DctP; COG1638
335659004374	Bacterial extracellular solute-binding protein, family 7; Region: SBP_bac_7; cl15441
335659004375	TRAP-type C4-dicarboxylate transport system, small permease component [Carbohydrate transport and metabolism]; Region: DctM; COG3090
335659004376	DctM-like transporters; Region: DctM; pfam06808
335659004377	TRAP-type C4-dicarboxylate transport system, large permease component [Carbohydrate transport and metabolism]; Region: DctQ; COG1593
335659004378	L-idonate 5-dehydrogenase; Provisional; Region: PRK09880
335659004379	L-idonate 5-dehydrogenase; Region: idonate-5-DH; cd08232
335659004380	putative NAD(P) binding site [chemical binding]; other site
335659004381	catalytic Zn binding site [ion binding]; other site
335659004382	mannonate dehydratase; Provisional; Region: PRK03906
335659004383	mannonate dehydratase; Region: uxuA; TIGR00695
335659004384	putative choline sulfate-utilization transcription factor; Region: chol_sulf_TF; TIGR03418
335659004385	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
335659004386	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
335659004387	dimerization interface [polypeptide binding]; other site
335659004388	ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842
335659004389	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
335659004390	Walker A/P-loop; other site
335659004391	ATP binding site [chemical binding]; other site
335659004392	Q-loop/lid; other site
335659004393	ABC transporter signature motif; other site
335659004394	Walker B; other site
335659004395	D-loop; other site
335659004396	H-loop/switch region; other site
335659004397	TOBE domain; Region: TOBE_2; pfam08402
335659004398	2-haloalkanoic acid dehalogenase, type II; Region: HAD_type_II; TIGR01428
335659004399	Haloacid dehalogenase superfamily, subfamily IA, variant 2 with 3rd motif like haloacid dehalogenase; Region: HAD-SF-IA-v2; TIGR01493
335659004400	putative aminophosphonate oxidoreductase; Region: Phn_aa_oxid; TIGR03329
335659004401	Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665
335659004402	Spermidine/putrescine-binding periplasmic protein [Amino acid transport and metabolism]; Region: PotD; COG0687
335659004403	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199
335659004404	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
335659004405	dimer interface [polypeptide binding]; other site
335659004406	conserved gate region; other site
335659004407	putative PBP binding loops; other site
335659004408	ABC-ATPase subunit interface; other site
335659004409	ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177
335659004410	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
335659004411	dimer interface [polypeptide binding]; other site
335659004412	conserved gate region; other site
335659004413	putative PBP binding loops; other site
335659004414	ABC-ATPase subunit interface; other site
335659004415	Predicted nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG0702
335659004416	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
335659004417	NAD(P) binding site [chemical binding]; other site
335659004418	active site
335659004419	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
335659004420	Choline dehydrogenase and related flavoproteins [Amino acid transport and metabolism]; Region: BetA; COG2303
335659004421	GMC oxidoreductase; Region: GMC_oxred_C; pfam05199
335659004422	Calcineurin-like phosphoesterase superfamily domain; Region: Metallophos_2; pfam12850
335659004423	Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149
335659004424	active site
335659004425	metal binding site [ion binding]; metal-binding site
335659004426	Predicted exonuclease of the beta-lactamase fold involved in RNA processing [Translation, ribosomal structure and biogenesis]; Region: YSH1; COG1236
335659004427	Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446
335659004428	Beta-lactamase superfamily domain; Region: Lactamase_B_2; pfam12706
335659004429	RNA-metabolising metallo-beta-lactamase; Region: RMMBL; pfam07521
335659004430	phosphoprotein phosphatases of the metallophosphatase superfamily, metallophosphatase domain; Region: MPP_PPP_family; cd00144
335659004431	Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149
335659004432	active site
335659004433	metal binding site [ion binding]; metal-binding site
335659004434	ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126
335659004435	ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262
335659004436	Walker A/P-loop; other site
335659004437	ATP binding site [chemical binding]; other site
335659004438	Q-loop/lid; other site
335659004439	ABC transporter signature motif; other site
335659004440	Walker B; other site
335659004441	D-loop; other site
335659004442	H-loop/switch region; other site
335659004443	ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215
335659004444	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
335659004445	dimer interface [polypeptide binding]; other site
335659004446	conserved gate region; other site
335659004447	putative PBP binding loops; other site
335659004448	ABC-ATPase subunit interface; other site
335659004449	Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497
335659004450	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
335659004451	substrate binding pocket [chemical binding]; other site
335659004452	membrane-bound complex binding site; other site
335659004453	Lactate dehydrogenase and related dehydrogenases [Energy production and conversion / Coenzyme metabolism / General function prediction only]; Region: LdhA; COG1052
335659004454	Formate/glycerate dehydrogenases, D-specific 2-hydroxy acid dehydrogenases and related dehydrogenases; Region: FDH_GDH_like; cl17240
335659004455	NAD binding site [chemical binding]; other site
335659004456	This group of proteins belong to a large family of YjgF/YER057c/UK114-like proteins present in bacteria, archaea, and eukaryotes with no definitive function.  The conserved domain is similar in structure to chorismate mutase but there is no sequence...; Region: YjgF_YER057c_UK114_like_2; cd06150
335659004457	homotrimer interaction site [polypeptide binding]; other site
335659004458	putative active site [active]
335659004459	aspartate aminotransferase; Provisional; Region: PRK05764
335659004460	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
335659004461	pyridoxal 5'-phosphate binding site [chemical binding]; other site
335659004462	homodimer interface [polypeptide binding]; other site
335659004463	catalytic residue [active]
335659004464	thiamine pyrophosphate protein; Validated; Region: PRK08199
335659004465	Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035
335659004466	PYR/PP interface [polypeptide binding]; other site
335659004467	dimer interface [polypeptide binding]; other site
335659004468	TPP binding site [chemical binding]; other site
335659004469	Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205
335659004470	Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cd00568
335659004471	TPP-binding site [chemical binding]; other site
335659004472	D-amino acid dehydrogenase small subunit; Validated; Region: PRK00711
335659004473	hydroxyglutarate oxidase; Provisional; Region: PRK11728
335659004474	hypothetical protein; Provisional; Region: PRK07475
335659004475	Transcriptional regulators [Transcription]; Region: GntR; COG1802
335659004476	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
335659004477	DNA-binding site [nucleotide binding]; DNA binding site
335659004478	FCD domain; Region: FCD; pfam07729
335659004479	Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035
335659004480	PYR/PP interface [polypeptide binding]; other site
335659004481	dimer interface [polypeptide binding]; other site
335659004482	TPP binding site [chemical binding]; other site
335659004483	Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cl01629
335659004484	TPP-binding site [chemical binding]; other site
335659004485	3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK07231
335659004486	classical (c) SDRs; Region: SDR_c; cd05233
335659004487	NAD(P) binding site [chemical binding]; other site
335659004488	active site
335659004489	ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395
335659004490	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
335659004491	dimer interface [polypeptide binding]; other site
335659004492	conserved gate region; other site
335659004493	putative PBP binding loops; other site
335659004494	ABC-ATPase subunit interface; other site
335659004495	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427
335659004496	ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555
335659004497	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
335659004498	dimer interface [polypeptide binding]; other site
335659004499	ABC-ATPase subunit interface; other site
335659004500	putative PBP binding loops; other site
335659004501	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653
335659004502	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547
335659004503	Transcriptional regulators [Transcription]; Region: PurR; COG1609
335659004504	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
335659004505	DNA binding site [nucleotide binding]
335659004506	domain linker motif; other site
335659004507	Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267
335659004508	dimerization interface [polypeptide binding]; other site
335659004509	ligand binding site [chemical binding]; other site
335659004510	ADP-ribosylglycohydrolase; Region: ADP_ribosyl_GH; pfam03747
335659004511	IclR helix-turn-helix domain; Region: HTH_IclR; cl17605
335659004512	Transcriptional regulator [Transcription]; Region: IclR; COG1414
335659004513	Bacterial transcriptional regulator; Region: IclR; pfam01614
335659004514	putative succinate dehydrogenase; Reviewed; Region: PRK12842
335659004515	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
335659004516	Predicted oxidoreductase [General function prediction only]; Region: COG3573
335659004517	Periplasmic binding protein; Region: Peripla_BP_6; pfam13458
335659004518	Periplasmic solute-binding domain of active transport proteins that belong to the type I periplasmic binding fold protein family; Region: PBP1_SBP_like_1; cd06327
335659004519	putative ligand binding site [chemical binding]; other site
335659004520	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
335659004521	metabolite-proton symporter; Region: 2A0106; TIGR00883
335659004522	putative substrate translocation pore; other site
335659004523	Spermidine/putrescine-binding periplasmic protein [Amino acid transport and metabolism]; Region: PotD; COG0687
335659004524	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
335659004525	dimer interface [polypeptide binding]; other site
335659004526	conserved gate region; other site
335659004527	ABC-ATPase subunit interface; other site
335659004528	ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177
335659004529	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
335659004530	dimer interface [polypeptide binding]; other site
335659004531	ABC-ATPase subunit interface; other site
335659004532	putative PBP binding loops; other site
335659004533	ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842
335659004534	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
335659004535	Walker A/P-loop; other site
335659004536	ATP binding site [chemical binding]; other site
335659004537	Q-loop/lid; other site
335659004538	ABC transporter signature motif; other site
335659004539	Walker B; other site
335659004540	D-loop; other site
335659004541	H-loop/switch region; other site
335659004542	Aerobic-type carbon monoxide dehydrogenase, small subunit CoxS/CutS homologs [Energy production and conversion]; Region: CoxS; COG2080
335659004543	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cl00159
335659004544	[2Fe-2S] binding domain; Region: Fer2_2; pfam01799
335659004545	Aerobic-type carbon monoxide dehydrogenase, large subunit CoxL/CutL homologs [Energy production and conversion]; Region: CoxL; COG1529
335659004546	Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; smart01008
335659004547	Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738
335659004548	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM/CutM homologs [Energy production and conversion]; Region: CoxM; COG1319
335659004549	CO dehydrogenase flavoprotein C-terminal domain; Region: CO_deh_flav_C; smart01092
335659004550	Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154
335659004551	Amidase; Region: Amidase; pfam01425
335659004552	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
335659004553	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
335659004554	dimerization interface [polypeptide binding]; other site
335659004555	Tripartite tricarboxylate transporter family receptor; Region: TctC; cl17792
335659004556	3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK05565
335659004557	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
335659004558	NAD(P) binding site [chemical binding]; other site
335659004559	active site
335659004560	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
335659004561	Putative lysophospholipase; Region: Hydrolase_4; pfam12146
335659004562	homoserine O-acetyltransferase; Provisional; Region: metX; cl17114
335659004563	2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179
335659004564	Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557
335659004565	IclR helix-turn-helix domain; Region: HTH_IclR; pfam09339
335659004566	Transcriptional regulator [Transcription]; Region: IclR; COG1414
335659004567	Bacterial transcriptional regulator; Region: IclR; pfam01614
335659004568	Citrate lyase beta subunit [Carbohydrate transport and metabolism]; Region: CitE; COG2301
335659004569	FkbR2 is a Streptomyces hygroscopicus protein with a hot dog fold that belongs to a conserved family of proteins found in prokaryotes and archaea but not in eukaryotes. FkbR2  has sequence similarity to (R)-specific enoyl-CoA hydratase, the peroxisomal...; Region: FkbR2; cd03451
335659004570	putative active site [active]
335659004571	putative catalytic site [active]
335659004572	Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804
335659004573	CoA-transferase family III; Region: CoA_transf_3; pfam02515
335659004574	TRAP-type C4-dicarboxylate transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: DctP; COG1638
335659004575	Bacterial extracellular solute-binding protein, family 7; Region: SBP_bac_7; cl15441
335659004576	Tripartite ATP-independent periplasmic transporters, DctQ component; Region: DctQ; pfam04290
335659004577	DctM-like transporters; Region: DctM; pfam06808
335659004578	TRAP-type C4-dicarboxylate transport system, large permease component [Carbohydrate transport and metabolism]; Region: DctQ; COG1593
335659004579	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
335659004580	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
335659004581	active site
335659004582	Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318
335659004583	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
335659004584	Bacterial Bile acid CoA ligases and similar proteins; Region: BACL_like; cd05929
335659004585	acyl-activating enzyme (AAE) consensus motif; other site
335659004586	acyl-activating enzyme (AAE) consensus motif; other site
335659004587	putative AMP binding site [chemical binding]; other site
335659004588	putative active site [active]
335659004589	putative CoA binding site [chemical binding]; other site
335659004590	butyryl-CoA:acetate CoA-transferase; Region: butyr_acet_CoA; TIGR03948
335659004591	Acetyl-CoA hydrolase/transferase C-terminal domain; Region: AcetylCoA_hyd_C; pfam13336
335659004592	Predicted hydrolase (HAD superfamily) [General function prediction only]; Region: COG5610
335659004593	RNA polymerase sigma factor; Provisional; Region: PRK12538
335659004594	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
335659004595	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
335659004596	DNA binding residues [nucleotide binding]
335659004597	Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669
335659004598	Bacterial flagellin C-terminal helical region; Region: Flagellin_C; pfam00700
335659004599	Flagellar hook-associated protein 2 C-terminus; Region: FliD_N; pfam02465
335659004600	flagellar capping protein; Provisional; Region: PRK12765
335659004601	Flagellar hook-associated protein 2 C-terminus; Region: FliD_C; pfam07195
335659004602	Flagellar hook-associated protein 2 C-terminus; Region: FliD_C; pfam07195
335659004603	Flagellar protein FliS; Region: FliS; cl00654
335659004604	Flagellar hook capping protein - N-terminal region; Region: FlgD; pfam03963
335659004605	FlgD Tudor-like domain; Region: FLgD_tudor; pfam13861
335659004606	flagellar hook protein FlgE; Validated; Region: flgE; PRK05682
335659004607	Flagellar basal body protein FlaE; Region: FlaE; pfam07559
335659004608	Flagellar hook-associated protein [Cell motility and secretion]; Region: FlgK; COG1256
335659004609	flagellar hook-associated protein FlgL; Validated; Region: flgL; PRK08913
335659004610	Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669
335659004611	acyl-CoA synthetase; Validated; Region: PRK06164
335659004612	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
335659004613	acyl-activating enzyme (AAE) consensus motif; other site
335659004614	AMP binding site [chemical binding]; other site
335659004615	active site
335659004616	CoA binding site [chemical binding]; other site
335659004617	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
335659004618	active site
335659004619	Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024
335659004620	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
335659004621	substrate binding site [chemical binding]; other site
335659004622	oxyanion hole (OAH) forming residues; other site
335659004623	trimer interface [polypeptide binding]; other site
335659004624	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
335659004625	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
335659004626	Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329
335659004627	Dihydrodipicolinate synthase (DHDPS); Region: DHDPS; cd00950
335659004628	dimer interface [polypeptide binding]; other site
335659004629	active site
335659004630	catalytic residue [active]
335659004631	potassium-transporting ATPase subunit A; Provisional; Region: PRK05482
335659004632	potassium-transporting ATPase subunit B; Provisional; Region: PRK01122
335659004633	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
335659004634	Soluble P-type ATPase [General function prediction only]; Region: COG4087
335659004635	potassium-transporting ATPase subunit C; Provisional; Region: PRK13999
335659004636	Osmosensitive K+ channel histidine kinase [Signal transduction mechanisms]; Region: KdpD; COG2205
335659004637	Osmosensitive K+ channel His kinase sensor domain; Region: KdpD; pfam02702
335659004638	USP domain is located between the N-terminal sensor domain and C-terminal catalytic domain of this Osmosensitive K+ channel histidine kinase family. The family of KdpD sensor kinase proteins regulates the kdpFABC operon responsible for potassium...; Region: USP_OKCHK; cd01987
335659004639	Ligand Binding Site [chemical binding]; other site
335659004640	Domain of unknown function (DUF4118); Region: DUF4118; pfam13493
335659004641	GAF domain; Region: GAF_3; pfam13492
335659004642	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
335659004643	dimer interface [polypeptide binding]; other site
335659004644	phosphorylation site [posttranslational modification]
335659004645	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
335659004646	ATP binding site [chemical binding]; other site
335659004647	Mg2+ binding site [ion binding]; other site
335659004648	G-X-G motif; other site
335659004649	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
335659004650	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
335659004651	active site
335659004652	phosphorylation site [posttranslational modification]
335659004653	intermolecular recognition site; other site
335659004654	dimerization interface [polypeptide binding]; other site
335659004655	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
335659004656	DNA binding site [nucleotide binding]
335659004657	Ku protein, prokaryotic; Region: Ku_bact; TIGR02772
335659004658	Ku-core domain, Ku-like subfamily; composed of prokaryotic homologs of the eukaryotic DNA binding protein Ku. The alignment includes the core domain shared by the prokaryotic YkoV-like proteins and the eukaryotic Ku70 and Ku80. The prokaryotic Ku...; Region: KU_like; cd00789
335659004659	putative DNA binding site [nucleotide binding]; other site
335659004660	putative homodimer interface [polypeptide binding]; other site
335659004661	ATP-dependent DNA ligase; Reviewed; Region: ligD; PRK05972
335659004662	DNA ligase D, 3'-phosphoesterase domain; Region: LigD_PE_dom; TIGR02777
335659004663	Adenylation domain of Mycobacterium tuberculosis LigD and LigC-like ATP-dependent DNA ligases; Region: Adenylation_DNA_ligase_LigD_LigC; cd07906
335659004664	active site
335659004665	DNA binding site [nucleotide binding]
335659004666	The Oligonucleotide/oligosaccharide binding (OB)-fold domain of ATP-dependent DNA ligase LigD is a DNA-binding module that is part of the catalytic core unit; Region: OBF_DNA_ligase_LigD; cd07971
335659004667	DNA binding site [nucleotide binding]
335659004668	Predicted eukaryotic-type DNA primase [DNA replication, recombination, and repair]; Region: COG3285
335659004669	nucleotide binding site [chemical binding]; other site
335659004670	Putative polyhydroxyalkanoic acid system protein (PHA_gran_rgn); Region: PHA_gran_rgn; cl09865
335659004671	malto-oligosyltrehalose synthase; Region: trehalose_TreY; TIGR02401
335659004672	Alpha amylase catalytic domain family; Region: AmyAc_family; cl07893
335659004673	Alpha amylase catalytic domain found in maltooligosyl trehalose synthase (MTSase); Region: AmyAc_MTSase; cd11336
335659004674	active site
335659004675	catalytic site [active]
335659004676	malto-oligosyltrehalose trehalohydrolase; Region: trehalose_TreZ; TIGR02402
335659004677	N-terminal Early set domain associated with the catalytic domain of Maltooligosyl trehalose trehalohydrolase (also called Glycosyltrehalose trehalohydrolase) and similar proteins; Region: E_set_MTHase_like_N; cd02853
335659004678	Alpha amylase catalytic domain found in Glycosyltrehalose trehalohydrolase (also called Maltooligosyl trehalose Trehalohydrolase); Region: AmyAc_GTHase; cd11325
335659004679	catalytic site [active]
335659004680	active site
335659004681	Domain of unknown function (DUF3459); Region: DUF3459; pfam11941
335659004682	glycogen debranching enzyme GlgX; Region: glgX_debranch; TIGR02100
335659004683	N-terminal Early set domain associated with the catalytic domain of Glycogen debranching enzyme and bacterial isoamylase (also called glycogen 6-glucanohydrolase); Region: E_set_GDE_Isoamylase_N; cd02856
335659004684	Alpha amylase catalytic domain found in glycogen debranching enzymes; Region: AmyAc_Glg_debranch; cd11326
335659004685	active site
335659004686	catalytic site [active]
335659004687	glycogen branching enzyme; Provisional; Region: PRK05402
335659004688	N-terminal Early set domain associated with the catalytic domain of prokaryotic glycogen branching enzyme; Region: E_set_GBE_prok_N; cd02855
335659004689	Alpha amylase catalytic domain found in the Glycogen branching enzyme (also called 1,4-alpha-glucan branching enzyme); Region: AmyAc_Glg_BE; cd11322
335659004690	active site
335659004691	catalytic site [active]
335659004692	Alpha amylase, C-terminal all-beta domain; Region: Alpha-amylase_C; pfam02806
335659004693	trehalose synthase; Region: treS_nterm; TIGR02456
335659004694	Alpha amylase catalytic domain found in Trehalose synthetase; Region: AmyAc_TreS; cd11334
335659004695	active site
335659004696	catalytic site [active]
335659004697	trehalose synthase-fused probable maltokinase; Region: TreS_Cterm; TIGR02457
335659004698	Uncharacterized protein, probably involved in trehalose biosynthesis [Carbohydrate transport and metabolism]; Region: Ble; COG3281
335659004699	Domain of unknown function (DUF3416); Region: DUF3416; pfam11896
335659004700	Alpha amylase catalytic domain family; Region: AmyAc_family; cl07893
335659004701	Glycosidases [Carbohydrate transport and metabolism]; Region: AmyA; COG0366
335659004702	active site
335659004703	catalytic site [active]
335659004704	4-alpha-glucanotransferase; Provisional; Region: malQ; PRK11052
335659004705	Penicillin-Binding Protein C-terminus Family; Region: BiPBP_C; pfam06832
335659004706	4-alpha-glucanotransferase [Carbohydrate transport and metabolism]; Region: MalQ; COG1640
335659004707	Glucoamylase and related glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: SGA1; COG3387
335659004708	Glycosyl hydrolases family 15; Region: Glyco_hydro_15; pfam00723
335659004709	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
335659004710	haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282
335659004711	active site
335659004712	motif I; other site
335659004713	motif II; other site
335659004714	haloacid dehalogenase-like hydrolase; Region: HAD; cl17202
335659004715	Gluconate kinase (GntK) catalyzes the phosphoryl transfer from ATP to gluconate. The resulting product gluconate-6-phoshate is an important precursor of gluconate metabolism. GntK acts as a dimmer composed of two identical subunits; Region: GntK; cd02021
335659004716	ATP-binding site [chemical binding]; other site
335659004717	Gluconate-6-phosphate binding site [chemical binding]; other site
335659004718	Shikimate kinase; Region: SKI; pfam01202
335659004719	6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase [Carbohydrate transport and metabolism]; Region: NagB; COG0363
335659004720	6PGL: 6-Phosphogluconolactonase (6PGL) subfamily; 6PGL catalyzes the second step of the oxidative phase of the pentose phosphate pathway, the hydrolyzation of 6-phosphoglucono-1,5-lactone (delta form) to 6-phosphogluconate. 6PGL is thought to guard...; Region: 6PGL; cd01400
335659004721	putative active site [active]
335659004722	glucose-6-phosphate 1-dehydrogenase; Validated; Region: PRK05722
335659004723	Glucose-6-phosphate dehydrogenase, NAD binding domain; Region: G6PD_N; pfam00479
335659004724	Glucose-6-phosphate dehydrogenase, C-terminal domain; Region: G6PD_C; pfam02781
335659004725	6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599
335659004726	Predicted 6-phosphogluconate dehydrogenase [Carbohydrate transport and metabolism]; Region: Gnd; COG1023
335659004727	bifunctional transaldolase/phosoglucose isomerase; Validated; Region: PRK09533
335659004728	Transaldolase-like proteins from plants and bacteria; Region: Transaldolase_like; cd00955
335659004729	putative active site [active]
335659004730	catalytic residue [active]
335659004731	Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the first SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_1; cd05015
335659004732	active site
335659004733	dimer interface [polypeptide binding]; other site
335659004734	SIS_TAL_PGI: Transaldolase (TAL)/ Phosphoglucose isomerase (PGI). This group represents the SIS (Sugar ISomerase) PGI domain, of a multifunctional protein (TAL-PGI ) having both TAL and PGI activities. TAL_PGI contains an N-terminal TAL domain and a...; Region: SIS_TAL_PGI; cd05798
335659004735	PrkA family serine protein kinase; Provisional; Region: PRK15455
335659004736	AAA ATPase domain; Region: AAA_16; pfam13191
335659004737	PrkA serine protein kinase C-terminal domain; Region: PrkA; pfam06798
335659004738	hypothetical protein; Provisional; Region: PRK05325
335659004739	SpoVR family protein; Provisional; Region: PRK11767
335659004740	Uncharacterized conserved protein [Function unknown]; Region: SpoVR; COG2719
335659004741	Uncharacterized conserved protein [Function unknown]; Region: COG5649
335659004742	Putative hydrophobic ligand-binding SRPBCC domain of Micromonospora echinospora CalC, human Aha1, and related proteins; Region: SRPBCC_CalC_Aha1-like; cd07814
335659004743	putative hydrophobic ligand binding site [chemical binding]; other site
335659004744	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
335659004745	dimerization interface [polypeptide binding]; other site
335659004746	putative DNA binding site [nucleotide binding]; other site
335659004747	putative Zn2+ binding site [ion binding]; other site
335659004748	DsrE/DsrF-like family; Region: DrsE; cl00672
335659004749	Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114
335659004750	cyclase homology domain; Region: CHD; cd07302
335659004751	nucleotidyl binding site; other site
335659004752	metal binding site [ion binding]; metal-binding site
335659004753	dimer interface [polypeptide binding]; other site
335659004754	Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; pfam03781
335659004755	Uncharacterized conserved protein [Function unknown]; Region: COG1262
335659004756	Domain of unknown function (DUF4399); Region: DUF4399; pfam14347
335659004757	2-oxoglutarate ferredoxin oxidoreductase subunit beta; Validated; Region: PRK05778
335659004758	Thiamine pyrophosphate (TPP family), 2-oxoglutarate ferredoxin oxidoreductase (OGFOR) subfamily, TPP-binding module; OGFOR catalyzes the oxidative decarboxylation of 2-oxo-acids, with ferredoxin acting as an electron acceptor. In the TCA cycle, OGFOR...; Region: TPP_OGFOR; cd03375
335659004759	TPP-binding site [chemical binding]; other site
335659004760	Pyruvate ferredoxin oxidoreductase beta subunit C terminal; Region: PFO_beta_C; pfam12367
335659004761	2-oxoacid:acceptor oxidoreductase, alpha subunit; Region: OAFO_sf; TIGR03710
335659004762	Pyruvate ferredoxin/flavodoxin oxidoreductase; Region: POR; pfam01558
335659004763	Pyrimidine (PYR) binding domain of pyruvate ferredoxin oxidoreductase (PFOR), indolepyruvate ferredoxin oxidoreductase alpha subunit (IOR-alpha), and related proteins; Region: TPP_PYR_PFOR_IOR-alpha_like; cd07034
335659004764	dimer interface [polypeptide binding]; other site
335659004765	PYR/PP interface [polypeptide binding]; other site
335659004766	TPP binding site [chemical binding]; other site
335659004767	substrate binding site [chemical binding]; other site
335659004768	putative glutamate synthase (NADPH) small subunit; Provisional; Region: PRK12771
335659004769	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
335659004770	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
335659004771	4Fe-4S binding domain; Region: Fer4; pfam00037
335659004772	4Fe-4S binding domain; Region: Fer4; pfam00037
335659004773	proline iminopeptidase, Neisseria-type subfamily; Region: pro_imino_pep_1; TIGR01249
335659004774	homoserine O-acetyltransferase; Provisional; Region: metX; cl17114
335659004775	TAP-like protein; Region: Abhydrolase_4; pfam08386
335659004776	pyrroloquinoline quinone biosynthesis protein PqqE; Provisional; Region: PRK05301
335659004777	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
335659004778	FeS/SAM binding site; other site
335659004779	radical SAM additional 4Fe4S-binding SPASM domain; Region: rSAM_more_4Fe4S; TIGR04085
335659004780	Coenzyme PQQ synthesis protein D (PqqD); Region: PqqD; pfam05402
335659004781	pyrroloquinoline quinone biosynthesis protein PqqC; Provisional; Region: PRK05157
335659004782	coenzyme PQQ biosynthesis protein B; Region: PQQ_syn_pqqB; TIGR02108
335659004783	pyrroloquinoline quinone biosynthesis protein PqqB; Provisional; Region: PRK05184
335659004784	coenzyme PQQ synthesis protein PqqA; Provisional; Region: pqqA; PRK00284
335659004785	amidase; Provisional; Region: PRK07487
335659004786	Amidase; Region: Amidase; cl11426
335659004787	Glutathione (GSH) peroxidase family; tetrameric selenoenzymes that catalyze the reduction of a variety of hydroperoxides including lipid peroxidases, using GSH as a specific electron donor substrate. GSH peroxidase contains one selenocysteine residue per...; Region: GSH_Peroxidase; cd00340
335659004788	catalytic residues [active]
335659004789	dimer interface [polypeptide binding]; other site
335659004790	Protein of unknown function (DUF3297); Region: DUF3297; pfam11730
335659004791	Malonyl-CoA decarboxylase (MCD); Region: MCD; pfam05292
335659004792	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
335659004793	S-adenosylmethionine binding site [chemical binding]; other site
335659004794	Tripartite tricarboxylate transporter family receptor; Region: TctC; cl17792
335659004795	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
335659004796	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
335659004797	DNA binding site [nucleotide binding]
335659004798	Predicted integral membrane protein [Function unknown]; Region: COG5616
335659004799	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
335659004800	TPR motif; other site
335659004801	binding surface
335659004802	AraC-like ligand binding domain; Region: AraC_binding; pfam02311
335659004803	Helix-turn-helix domain; Region: HTH_18; pfam12833
335659004804	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
335659004805	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
335659004806	Major Facilitator Superfamily; Region: MFS_1; pfam07690
335659004807	putative substrate translocation pore; other site
335659004808	The (Largely Gram-negative Bacterial) Hydrophobe/Amphiphile Efflux-1 (HAE1) Family; Region: 2A0602; TIGR00915
335659004809	NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961
335659004810	Protein export membrane protein; Region: SecD_SecF; cl14618
335659004811	RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730
335659004812	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
335659004813	HlyD family secretion protein; Region: HlyD_3; pfam13437
335659004814	Bacterial periplasmic substrate-binding proteins; Region: PBPb; smart00062
335659004815	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
335659004816	substrate binding pocket [chemical binding]; other site
335659004817	membrane-bound complex binding site; other site
335659004818	hinge residues; other site
335659004819	Cupin domain; Region: Cupin_2; pfam07883
335659004820	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
335659004821	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
335659004822	putative active site [active]
335659004823	heme pocket [chemical binding]; other site
335659004824	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
335659004825	dimer interface [polypeptide binding]; other site
335659004826	phosphorylation site [posttranslational modification]
335659004827	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
335659004828	ATP binding site [chemical binding]; other site
335659004829	G-X-G motif; other site
335659004830	FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784
335659004831	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
335659004832	active site
335659004833	phosphorylation site [posttranslational modification]
335659004834	intermolecular recognition site; other site
335659004835	DNA-binding transcriptional repressor PuuR; Provisional; Region: PRK09943
335659004836	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
335659004837	non-specific DNA binding site [nucleotide binding]; other site
335659004838	salt bridge; other site
335659004839	sequence-specific DNA binding site [nucleotide binding]; other site
335659004840	Cupin domain; Region: Cupin_2; pfam07883
335659004841	ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747
335659004842	The substrate-binding component of ABC-type thermophilic oligopeptide-binding protein Hb8-like import systems, contains the type 2 periplasmic binding fold; Region: PBP2_thermophilic_Hb8_like; cd08513
335659004843	peptide binding site [polypeptide binding]; other site
335659004844	dimer interface [polypeptide binding]; other site
335659004845	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601
335659004846	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
335659004847	dimer interface [polypeptide binding]; other site
335659004848	conserved gate region; other site
335659004849	putative PBP binding loops; other site
335659004850	ABC-ATPase subunit interface; other site
335659004851	glutathione ABC transporter permease GsiD; Provisional; Region: PRK15082
335659004852	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427
335659004853	Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665
335659004854	putative aminophosphonate oxidoreductase; Region: Phn_aa_oxid; TIGR03329
335659004855	Putative glycerate dehydrogenase and related proteins of the D-specific 2-hydroxy dehydrogenase family; Region: GDH_like_2; cd12164
335659004856	Phosphoglycerate dehydrogenase and related dehydrogenases [Amino acid transport and metabolism]; Region: SerA; COG0111
335659004857	putative ligand binding site [chemical binding]; other site
335659004858	NAD binding site [chemical binding]; other site
335659004859	dimerization interface [polypeptide binding]; other site
335659004860	catalytic site [active]
335659004861	ATPase components of various ABC-type transport systems, contain duplicated ATPase [General function prediction only]; Region: COG1123
335659004862	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
335659004863	Walker A/P-loop; other site
335659004864	ATP binding site [chemical binding]; other site
335659004865	Q-loop/lid; other site
335659004866	ABC transporter signature motif; other site
335659004867	Walker B; other site
335659004868	D-loop; other site
335659004869	H-loop/switch region; other site
335659004870	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097
335659004871	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
335659004872	Walker A/P-loop; other site
335659004873	ATP binding site [chemical binding]; other site
335659004874	Q-loop/lid; other site
335659004875	ABC transporter signature motif; other site
335659004876	Walker B; other site
335659004877	D-loop; other site
335659004878	H-loop/switch region; other site
335659004879	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; pfam08352
335659004880	polyhydroxyalkanoate depolymerase, intracellular; Region: PHB_depoly_PhaZ; TIGR01849
335659004881	PHB de-polymerase C-terminus; Region: PHB_depo_C; pfam06850
335659004882	GST_N family, unknown subfamily 1; composed of uncharacterized proteins, predominantly from bacteria, with similarity to GSTs. GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with...; Region: GST_N_1; cd03043
335659004883	Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625
335659004884	putative C-terminal domain interface [polypeptide binding]; other site
335659004885	putative GSH binding site (G-site) [chemical binding]; other site
335659004886	putative dimer interface [polypeptide binding]; other site
335659004887	C-terminal, alpha helical domain of an unknown subfamily 3 of Glutathione S-transferases; Region: GST_C_3; cd03194
335659004888	putative N-terminal domain interface [polypeptide binding]; other site
335659004889	putative dimer interface [polypeptide binding]; other site
335659004890	putative substrate binding pocket (H-site) [chemical binding]; other site
335659004891	L-alanine-DL-glutamate epimerase and related enzymes of enolase superfamily [Cell envelope biogenesis, outer membrane / General function prediction only]; Region: COG4948
335659004892	Mandelate racemase (MR)-like subfamily of the enolase superfamily. Enzymes of this subgroup share three conserved carboxylate ligands for the essential divalent metal ion (usually Mg2+), two aspartates and a glutamate, and conserved catalytic residues; Region: MR_like; cd03316
335659004893	active site pocket [active]
335659004894	SMP-30/Gluconolaconase/LRE-like region; Region: SGL; pfam08450
335659004895	Strictosidine synthase; Region: Str_synth; pfam03088
335659004896	Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302
335659004897	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182
335659004898	choline dehydrogenase; Validated; Region: PRK02106
335659004899	GMC oxidoreductase; Region: GMC_oxred_C; pfam05199
335659004900	Protein of unknown function (DUF497); Region: DUF497; cl01108
335659004901	Domain of unknown function (DUF4415); Region: DUF4415; pfam14384
335659004902	ATPases associated with a variety of cellular activities; Region: AAA; smart00382
335659004903	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
335659004904	Walker A motif; other site
335659004905	ATP binding site [chemical binding]; other site
335659004906	Walker B motif; other site
335659004907	arginine finger; other site
335659004908	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3825
335659004909	Polysulfide-sulfurtransferase - Rhodanese Homology Domain. This domain is believed to serve as a polysulfide binding and transferase domain in anaerobic gram-negative bacteria, functioning in oxidative phosphorylation with polysulfide-sulfur as a...; Region: Polysulfide_ST; cd01447
335659004910	active site
335659004911	catalytic residue [active]
335659004912	Rhodanese-related sulfurtransferase [Inorganic ion transport and metabolism]; Region: SseA; COG2897
335659004913	Thiosulfate sulfurtransferase (TST), N-terminal, inactive domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the 1st repeat, which does not contain the catalytically active Cys residue. The role of the 1st repeat is uncertain, but it...; Region: TST_Repeat_1; cd01448
335659004914	active site residue [active]
335659004915	Thiosulfate sulfurtransferase (TST), C-terminal, catalytic domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the second repeat. Only the second repeat contains the catalytically active Cys residue; Region: TST_Repeat_2; cd01449
335659004916	active site residue [active]
335659004917	Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376
335659004918	L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734
335659004919	Putative D-3-Phosphoglycerate Dehydrogenases; Region: PGDH_like_1; cd12169
335659004920	dimerization interface [polypeptide binding]; other site
335659004921	NAD binding site [chemical binding]; other site
335659004922	Lactate dehydrogenase and related dehydrogenases [Energy production and conversion / Coenzyme metabolism / General function prediction only]; Region: LdhA; COG1052
335659004923	ligand binding site [chemical binding]; other site
335659004924	catalytic site [active]
335659004925	putative ABC transporter ATP-binding protein; Reviewed; Region: PRK11819
335659004926	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
335659004927	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
335659004928	Walker A/P-loop; other site
335659004929	ATP binding site [chemical binding]; other site
335659004930	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
335659004931	ABC transporter signature motif; other site
335659004932	ABC transporter; Region: ABC_tran_2; pfam12848
335659004933	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
335659004934	lytic murein transglycosylase; Region: MltB_2; TIGR02283
335659004935	Lytic Transglycosylase (LT)  and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL).  LTs...; Region: LT_GEWL; cd00254
335659004936	N-acetyl-D-glucosamine binding site [chemical binding]; other site
335659004937	Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471
335659004938	BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324
335659004939	Bacterioferritin (cytochrome b1) [Inorganic ion transport and metabolism]; Region: Bfr; COG2193
335659004940	Bacterioferritin, ferritin-like diiron-binding domain; Region: Bacterioferritin; cd00907
335659004941	heme binding site [chemical binding]; other site
335659004942	ferroxidase pore; other site
335659004943	ferroxidase diiron center [ion binding]; other site
335659004944	PPOX class probable FMN-dependent enzyme, DR_2398 family; Region: PPOX_FMN_DR2398; TIGR04025
335659004945	Predicted membrane protein [Function unknown]; Region: COG4270
335659004946	hypothetical protein; Provisional; Region: PRK06489
335659004947	homoserine O-acetyltransferase; Provisional; Region: metX; cl17114
335659004948	Uncharacterized conserved protein (DUF2277); Region: DUF2277; pfam10041
335659004949	Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954
335659004950	3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653
335659004951	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
335659004952	NAD(P) binding site [chemical binding]; other site
335659004953	active site
335659004954	DnaJ domain or J-domain.  DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cl02542
335659004955	HSP70 interaction site [polypeptide binding]; other site
335659004956	YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448
335659004957	homotrimer interaction site [polypeptide binding]; other site
335659004958	putative active site [active]
335659004959	Opacity protein and related surface antigens [Cell envelope biogenesis, outer membrane]; Region: COG3637
335659004960	Opacity protein and related surface antigens [Cell envelope biogenesis, outer membrane]; Region: COG3637
335659004961	GST_N family, Saccharomyces cerevisiae GTT1-like subfamily; composed of predominantly uncharacterized proteins with similarity to the S. cerevisiae GST protein, GTT1, and the Schizosaccharomyces pombe GST-III. GSTs are cytosolic dimeric proteins involved...; Region: GST_N_GTT1_like; cd03046
335659004962	putative C-terminal domain interface [polypeptide binding]; other site
335659004963	putative GSH binding site (G-site) [chemical binding]; other site
335659004964	Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625
335659004965	putative dimer interface [polypeptide binding]; other site
335659004966	C-terminal, alpha helical domain of an unknown subfamily 8 of Glutathione S-transferases; Region: GST_C_8; cd03207
335659004967	N-terminal domain interface [polypeptide binding]; other site
335659004968	putative substrate binding pocket (H-site) [chemical binding]; other site
335659004969	dimer interface [polypeptide binding]; other site
335659004970	Escherichia coli PhnB and similar proteins; the E. coli phnB gene is found next to an operon involved in the cleavage of carbon-phosphorus bonds in unactivated alkylphosphonates; Region: PhnB_like; cd06588
335659004971	dimer interface [polypeptide binding]; other site
335659004972	FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784
335659004973	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
335659004974	active site
335659004975	phosphorylation site [posttranslational modification]
335659004976	intermolecular recognition site; other site
335659004977	dimerization interface [polypeptide binding]; other site
335659004978	G:T/U mismatch specific DNA glcosylase (MUG); Region: UDG_F2_MUG; cd10028
335659004979	active site
335659004980	SUMO-1 interface [polypeptide binding]; other site
335659004981	thiamine biosynthesis protein ThiC; Provisional; Region: PRK09284
335659004982	ThiC-associated domain; Region: ThiC-associated; pfam13667
335659004983	Thiamine biosynthesis protein ThiC [Coenzyme metabolism]; Region: ThiC; COG0422
335659004984	Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5-; Region: TMP_TenI; cd00564
335659004985	thiamine phosphate binding site [chemical binding]; other site
335659004986	active site
335659004987	pyrophosphate binding site [ion binding]; other site
335659004988	Thiazole synthase (ThiG) is the tetrameric enzyme that is involved in the formation of the thiazole moiety of thiamin pyrophosphate, an essential ubiquitous cofactor that plays an important role in carbohydrate and amino acid metabolism. ThiG catalyzes...; Region: ThiG; cd04728
335659004989	ThiS interaction site; other site
335659004990	putative active site [active]
335659004991	tetramer interface [polypeptide binding]; other site
335659004992	ThiaminS ubiquitin-like sulfur carrier protein; Region: ThiS; cd00565
335659004993	thiS-thiF/thiG interaction site; other site
335659004994	glycine oxidase ThiO; Region: thiamin_ThiO; TIGR02352
335659004995	hydroxyglutarate oxidase; Provisional; Region: PRK11728
335659004996	TPP riboswitch (THI element) as predicted by Rfam v8.1 (RF00059), score 65.23
335659004997	Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741
335659004998	Lytic Transglycosylase (LT)  and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL).  LTs...; Region: LT_GEWL; cd00254
335659004999	N-acetyl-D-glucosamine binding site [chemical binding]; other site
335659005000	catalytic residue [active]
335659005001	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
335659005002	dimerization interface [polypeptide binding]; other site
335659005003	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
335659005004	dimer interface [polypeptide binding]; other site
335659005005	phosphorylation site [posttranslational modification]
335659005006	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
335659005007	ATP binding site [chemical binding]; other site
335659005008	Mg2+ binding site [ion binding]; other site
335659005009	G-X-G motif; other site
335659005010	osmolarity response regulator; Provisional; Region: ompR; PRK09468
335659005011	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
335659005012	active site
335659005013	phosphorylation site [posttranslational modification]
335659005014	intermolecular recognition site; other site
335659005015	dimerization interface [polypeptide binding]; other site
335659005016	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
335659005017	DNA binding site [nucleotide binding]
335659005018	PRC-barrel domain; Region: PRC; pfam05239
335659005019	Periplasmic binding protein; Region: Peripla_BP_6; pfam13458
335659005020	Periplasmic solute-binding domain of active transport proteins that belong to the type I periplasmic binding fold protein family; Region: PBP1_SBP_like_1; cd06327
335659005021	putative ligand binding site [chemical binding]; other site
335659005022	ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177
335659005023	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
335659005024	dimer interface [polypeptide binding]; other site
335659005025	conserved gate region; other site
335659005026	putative PBP binding loops; other site
335659005027	ABC-ATPase subunit interface; other site
335659005028	ABC-type Fe3+ transport system, permease component [Inorganic ion transport and metabolism]; Region: ThiP; COG1178
335659005029	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
335659005030	dimer interface [polypeptide binding]; other site
335659005031	conserved gate region; other site
335659005032	putative PBP binding loops; other site
335659005033	ABC-ATPase subunit interface; other site
335659005034	Spermidine/putrescine-binding periplasmic protein [Amino acid transport and metabolism]; Region: PotD; COG0687
335659005035	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199
335659005036	ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842
335659005037	ATP-binding cassette domain of the polyamine transporter; Region: ABC_PotA_N; cd03300
335659005038	Walker A/P-loop; other site
335659005039	ATP binding site [chemical binding]; other site
335659005040	Q-loop/lid; other site
335659005041	ABC transporter signature motif; other site
335659005042	Walker B; other site
335659005043	D-loop; other site
335659005044	H-loop/switch region; other site
335659005045	TOBE domain; Region: TOBE_2; pfam08402
335659005046	Domain of unknown function (DUF4403); Region: DUF4403; pfam14356
335659005047	Glutamine cyclotransferase [Posttranslational modification, protein turnover, chaperones]; Region: COG3823
335659005048	Bacterial protein of unknown function (DUF899); Region: DUF899; pfam05988
335659005049	Cytochrome c; Region: Cytochrom_C; cl11414
335659005050	Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376
335659005051	L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734
335659005052	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
335659005053	This family is most closely related to the GT1 family of glycosyltransferases. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can...; Region: GT1_like_2; cd03814
335659005054	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
335659005055	S-adenosylmethionine binding site [chemical binding]; other site
335659005056	Glutamate-1-semialdehyde aminotransferase [Coenzyme metabolism]; Region: HemL; COG0001
335659005057	Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321
335659005058	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
335659005059	catalytic residue [active]
335659005060	Phosphatidylserine decarboxylase; Region: PS_Dcarbxylase; pfam02666
335659005061	Diadenosine hexaphosphate (Ap6A) hydrolase is a member of the Nudix hydrolase superfamily. Ap6A hydrolase specifically hydrolyzes diadenosine polyphosphates, but not ATP or diadenosine triphosphate, and it generates ATP as the product. Ap6A, the most...; Region: Ap6A_hydrolase; cd03673
335659005062	active site
335659005063	Ap6A binding site [chemical binding]; other site
335659005064	nudix motif; other site
335659005065	metal binding site [ion binding]; metal-binding site
335659005066	Uncharacterized protein conserved in bacteria (DUF2147); Region: DUF2147; pfam09917
335659005067	Uncharacterized protein conserved in bacteria (DUF2147); Region: DUF2147; pfam09917
335659005068	Extensin-like protein C-terminus; Region: Extensin-like_C; pfam06904
335659005069	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
335659005070	catalytic core [active]
335659005071	Peptidase M20 acetylornithine deacetylase/succinyl-diaminopimelate desuccinylase (ArgE/DapE)-like; Region: M20_ArgE_DapE_like; cd08659
335659005072	Acetylornithine deacetylase/Succinyl-diaminopimelate desuccinylase and related deacylases [Amino acid transport and metabolism]; Region: ArgE; COG0624
335659005073	metal binding site [ion binding]; metal-binding site
335659005074	dimer interface [polypeptide binding]; other site
335659005075	ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600
335659005076	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
335659005077	dimer interface [polypeptide binding]; other site
335659005078	conserved gate region; other site
335659005079	putative PBP binding loops; other site
335659005080	ABC-ATPase subunit interface; other site
335659005081	ABC-type taurine transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: TauA; COG4521
335659005082	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
335659005083	substrate binding pocket [chemical binding]; other site
335659005084	membrane-bound complex binding site; other site
335659005085	hinge residues; other site
335659005086	Protein of unknown function (DUF3834); Region: DUF3834; pfam12916
335659005087	Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154
335659005088	Amidase; Region: Amidase; cl11426
335659005089	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
335659005090	cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664
335659005091	ligand binding site [chemical binding]; other site
335659005092	flexible hinge region; other site
335659005093	helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092
335659005094	putative switch regulator; other site
335659005095	non-specific DNA interactions [nucleotide binding]; other site
335659005096	DNA binding site [nucleotide binding]
335659005097	sequence specific DNA binding site [nucleotide binding]; other site
335659005098	putative cAMP binding site [chemical binding]; other site
335659005099	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
335659005100	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
335659005101	AefR-like transcriptional repressor, C-terminal region; Region: TetR_C_7; pfam14246
335659005102	efflux pump membrane protein (multidrug resistance protein A); Region: 8a0101; TIGR00998
335659005103	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
335659005104	HlyD family secretion protein; Region: HlyD_3; pfam13437
335659005105	drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711
335659005106	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
335659005107	putative substrate translocation pore; other site
335659005108	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
335659005109	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
335659005110	ATP-binding cassette domain of the bacterial lipid flippase and related proteins, subfamily C; Region: ABCC_MsbA; cd03251
335659005111	Walker A/P-loop; other site
335659005112	ATP binding site [chemical binding]; other site
335659005113	Q-loop/lid; other site
335659005114	ABC transporter signature motif; other site
335659005115	Walker B; other site
335659005116	D-loop; other site
335659005117	H-loop/switch region; other site
335659005118	Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; Region: MATE_like_13; cd13141
335659005119	Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534
335659005120	O-Antigen ligase; Region: Wzy_C; pfam04932
335659005121	DsrE/DsrF/DrsH-like family; Region: DrsE_2; cl17453
335659005122	Sulfite exporter TauE/SafE; Region: TauE; pfam01925
335659005123	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167
335659005124	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
335659005125	DNA-binding site [nucleotide binding]; DNA binding site
335659005126	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
335659005127	pyridoxal 5'-phosphate binding site [chemical binding]; other site
335659005128	homodimer interface [polypeptide binding]; other site
335659005129	catalytic residue [active]
335659005130	Protein of unknown function (DUF983); Region: DUF983; cl02211
335659005131	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3795
335659005132	Predicted RNA polymerase sigma factor containing a TPR repeat domain [Transcription]; Region: COG4941
335659005133	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
335659005134	Sigma-70, region 4; Region: Sigma70_r4_2; pfam08281
335659005135	N-acetyl-anhydromuramyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: ampD; COG3023
335659005136	Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583
335659005137	amidase catalytic site [active]
335659005138	Zn binding residues [ion binding]; other site
335659005139	substrate binding site [chemical binding]; other site
335659005140	Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471
335659005141	MraW methylase family; Region: Methyltransf_5; cl17771
335659005142	16S rRNA m(4)C1402 methyltranserfase; Provisional; Region: PRK00050
335659005143	Predicted secreted (periplasmic) protein [Function unknown]; Region: COG5462
335659005144	Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768
335659005145	Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717
335659005146	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905
335659005147	UDP-N-acetylmuramoylalanyl-D-glutamate--2, 6-diaminopimelate ligase; Provisional; Region: murE; PRK00139
335659005148	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
335659005149	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
335659005150	UDP-N-acetylmuramyl pentapeptide synthase [Cell envelope biogenesis, outer membrane]; Region: MurF; COG0770
335659005151	Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225
335659005152	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
335659005153	phospho-N-acetylmuramoyl-pentapeptide-transferase; Provisional; Region: mraY; PRK00108
335659005154	Phospho-N-acetylmuramoyl-pentapeptide-transferase (mraY) is an enzyme responsible for the formation of the first lipid intermediate in the synthesis of bacterial cell wall peptidoglycan. It catalyzes the formation of...; Region: GT_MraY; cd06852
335659005155	Mg++ binding site [ion binding]; other site
335659005156	putative catalytic motif [active]
335659005157	putative substrate binding site [chemical binding]; other site
335659005158	UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase; Provisional; Region: murD; PRK01390
335659005159	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
335659005160	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
335659005161	cell division protein FtsW; Region: ftsW; TIGR02614
335659005162	undecaprenyldiphospho-muramoylpentapeptide beta-N- acetylglucosaminyltransferase; Provisional; Region: murG; PRK00726
335659005163	MurG is an N-acetylglucosaminyltransferase, the last enzyme involved in the intracellular phase of peptidoglycan biosynthesis. It transfers N-acetyl-D-glucosamine (GlcNAc) from UDP-GlcNAc to the C4 hydroxyl of a lipid-linked N-acetylmuramoyl pentapeptide...; Region: GT1_MurG; cd03785
335659005164	active site
335659005165	homodimer interface [polypeptide binding]; other site
335659005166	UDP-N-acetylmuramate--L-alanine ligase; Provisional; Region: murC; PRK00421
335659005167	Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225
335659005168	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
335659005169	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
335659005170	UDP-N-acetylenolpyruvoylglucosamine reductase; Provisional; Region: murB; PRK13905
335659005171	FAD binding domain; Region: FAD_binding_4; pfam01565
335659005172	UDP-N-acetylenolpyruvoylglucosamine reductase, C-terminal domain; Region: MurB_C; pfam02873
335659005173	D-alanine--D-alanine ligase; Reviewed; Region: ddl; PRK01372
335659005174	D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820
335659005175	ATP-grasp domain; Region: ATP-grasp_4; cl17255
335659005176	Cell division septal protein [Cell envelope biogenesis, outer membrane]; Region: FtsQ; COG1589
335659005177	POTRA domain, FtsQ-type; Region: POTRA_1; pfam08478
335659005178	Cell division protein FtsQ; Region: FtsQ; pfam03799
335659005179	Cell division ATPase FtsA [Cell division and chromosome partitioning]; Region: ftsA; COG0849
335659005180	Cell division protein FtsA; Region: FtsA; smart00842
335659005181	Cell division protein FtsA; Region: FtsA; pfam14450
335659005182	Cell division GTPase [Cell division and chromosome partitioning]; Region: FtsZ; COG0206
335659005183	FtsZ is a GTPase that is similar to the eukaryotic tubulins and is essential for cell division in prokaryotes.  FtsZ is capable of polymerizing in a GTP-driven process into structures similar to those formed by tubulin. FtsZ forms a ring-shaped septum at...; Region: FtsZ_type1; cd02201
335659005184	nucleotide binding site [chemical binding]; other site
335659005185	SulA interaction site; other site
335659005186	cell division protein FtsZ, alphaProteobacterial C-terminal extension; Region: FtsZ_alphas_C; TIGR03483
335659005187	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase; Reviewed; Region: lpxC; PRK13186
335659005188	UDP-3-O-acyl N-acetylglycosamine deacetylase; Region: LpxC; pfam03331
335659005189	outer membrane assembly lipoprotein YfiO; Region: OM_YfiO; TIGR03302
335659005190	ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: RecN; COG0497
335659005191	ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241
335659005192	Walker A/P-loop; other site
335659005193	ATP binding site [chemical binding]; other site
335659005194	Q-loop/lid; other site
335659005195	ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241
335659005196	ABC transporter signature motif; other site
335659005197	Walker B; other site
335659005198	D-loop; other site
335659005199	H-loop/switch region; other site
335659005200	NAD-dependent DNA ligase LigA; Validated; Region: ligA; PRK07956
335659005201	NAD+ dependent DNA ligase adenylation domain. DNA ligases catalyze the crucial step of joining the breaks in duplex DNA during DNA replication, repair and recombination, utilizing either ATP or NAD(+) as a cofactor, but using the same basic reaction...; Region: LIGANc; cd00114
335659005202	nucleotide binding pocket [chemical binding]; other site
335659005203	K-X-D-G motif; other site
335659005204	catalytic site [active]
335659005205	NAD-dependent DNA ligase OB-fold domain; Region: DNA_ligase_OB; pfam03120
335659005206	Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo...; Region: BRCT; cd00027
335659005207	Dimer interface [polypeptide binding]; other site
335659005208	BRCT sequence motif; other site
335659005209	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
335659005210	drug resistance transporter, Bcr/CflA subfamily; Region: efflux_Bcr_CflA; TIGR00710
335659005211	putative substrate translocation pore; other site
335659005212	Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321
335659005213	Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006
335659005214	X-Prolyl Aminopeptidase 2. E.C. 3.4.11.9. Also known as X-Pro aminopeptidase, proline aminopeptidase, aminopeptidase P, and aminoacylproline aminopeptidase. Catalyses release of any N-terminal amino acid, including proline, that is linked with proline; Region: APP; cd01085
335659005215	active site
335659005216	Ribosomal protein L11 methylase [Translation, ribosomal structure and biogenesis]; Region: PrmA; COG2264
335659005217	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173
335659005218	Flp pilus assembly protein, pilin Flp [Intracellular trafficking and secretion]; Region: Flp; COG3847
335659005219	Phytoene dehydrogenase and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG1233
335659005220	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173
335659005221	Glycerophosphodiester phosphodiesterase domain of putative Silicibacter pomeroyi glycerophosphodiester phosphodiesterase and similar proteins; Region: GDPD_SpGDE_like; cd08567
335659005222	Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584
335659005223	active site
335659005224	catalytic site [active]
335659005225	metal binding site [ion binding]; metal-binding site
335659005226	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
335659005227	TPR motif; other site
335659005228	Tetratricopeptide repeat; Region: TPR_12; pfam13424
335659005229	binding surface
335659005230	Tetratricopeptide repeat; Region: TPR_12; pfam13424
335659005231	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
335659005232	binding surface
335659005233	TPR motif; other site
335659005234	Tetratricopeptide repeat; Region: TPR_12; pfam13424
335659005235	Tetratricopeptide repeat; Region: TPR_12; pfam13424
335659005236	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
335659005237	binding surface
335659005238	TPR motif; other site
335659005239	Tetratricopeptide repeat; Region: TPR_12; pfam13424
335659005240	Tetratricopeptide repeat; Region: TPR_12; pfam13424
335659005241	CHAT domain; Region: CHAT; pfam12770
335659005242	L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734
335659005243	ABC-2 type transporter; Region: ABC2_membrane; cl17235
335659005244	ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842
335659005245	ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131
335659005246	ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230
335659005247	Walker A/P-loop; other site
335659005248	ATP binding site [chemical binding]; other site
335659005249	Q-loop/lid; other site
335659005250	ABC transporter signature motif; other site
335659005251	Walker B; other site
335659005252	D-loop; other site
335659005253	H-loop/switch region; other site
335659005254	Uncharacterized protein conserved in bacteria (DUF2248); Region: DUF2248; pfam10005
335659005255	Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596
335659005256	Conserved protein containing a Zn-ribbon-like motif, possibly RNA-binding [General function prediction only]; Region: COG5516
335659005257	Protein of unknown function (DUF1470); Region: DUF1470; pfam07336
335659005258	CGNR zinc finger; Region: zf-CGNR; pfam11706
335659005259	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
335659005260	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
335659005261	Protein of unknown function (DUF3313); Region: DUF3313; pfam11769
335659005262	Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695
335659005263	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
335659005264	Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071
335659005265	Alpha-crystallin domain (ACD) found in Escherichia coli inclusion body-associated proteins IbpA and IbpB, and similar proteins.  IbpA and IbpB are 16 kDa small heat shock proteins (sHsps). sHsps are molecular chaperones that suppress protein aggregation...; Region: ACD_IbpA-B_like; cd06470
335659005266	putative dimer interface [polypeptide binding]; other site
335659005267	repression of heat shock gene expression (ROSE) element as predicted by Rfam v8.1 (RF00435), score 63.34
335659005268	Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071
335659005269	Alpha-crystallin domain (ACD) of alpha-crystallin-type small(s) heat shock proteins (Hsps). sHsps are small stress induced proteins with monomeric masses between 12 -43 kDa, whose common feature is the Alpha-crystallin domain  (ACD). sHsps are generally...; Region: ACD_sHsps-like; cd06464
335659005270	putative dimer interface [polypeptide binding]; other site
335659005271	Isocitrate/isopropylmalate dehydrogenase [Amino acid transport and metabolism]; Region: LeuB; COG0473
335659005272	tartrate dehydrogenase; Region: TTC; TIGR02089
335659005273	DNA-binding transcriptional regulator HcaR; Provisional; Region: PRK09906
335659005274	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
335659005275	The C-terminal substrate binding domain of LysR-type transcriptional regulators involved in the catabolism of aromatic compounds and that of other related regulators, contains type 2 periplasmic binding fold; Region: PBP2_LTTR_aromatics_like; cd08414
335659005276	dimerization interface [polypeptide binding]; other site
335659005277	substrate binding pocket [chemical binding]; other site
335659005278	putative L-aspartate dehydrogenase; Provisional; Region: PRK13302
335659005279	Homoserine dehydrogenase, NAD binding domain; Region: NAD_binding_3; pfam03447
335659005280	Domain of unknown function DUF108; Region: DUF108; pfam01958
335659005281	Glucose/sorbosone dehydrogenases [Carbohydrate transport and metabolism]; Region: COG2133
335659005282	Putative protein-S-isoprenylcysteine methyltransferase [Posttranslational modification, protein turnover, chaperones]; Region: STE14; COG2020
335659005283	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
335659005284	NAD(P) binding site [chemical binding]; other site
335659005285	active site
335659005286	Protein of unknown function (DUF962); Region: DUF962; cl01879
335659005287	Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185
335659005288	ligand binding site [chemical binding]; other site
335659005289	Uncharacterized protein family (UPF0150); Region: UPF0150; pfam03681
335659005290	ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042
335659005291	CobQ/CobB/MinD/ParA nucleotide binding domain; Region: CbiA; pfam01656
335659005292	P-loop; other site
335659005293	Magnesium ion binding site [ion binding]; other site
335659005294	Superfamily I DNA and RNA helicases [DNA replication, recombination, and repair]; Region: UvrD; COG0210
335659005295	Part of AAA domain; Region: AAA_19; pfam13245
335659005296	Family description; Region: UvrD_C_2; pfam13538
335659005297	4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586
335659005298	active site
335659005299	FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277
335659005300	FAD binding domain; Region: FAD_binding_4; pfam01565
335659005301	Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659
335659005302	Sulfate transporter N-terminal domain with GLY motif; Region: Sulfate_tra_GLY; pfam13792
335659005303	Sulfate transporter family; Region: Sulfate_transp; pfam00916
335659005304	Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function; Region: STAS_SulP_like_sulfate_transporter; cd07042
335659005305	Caspase domain; Region: Peptidase_C14; pfam00656
335659005306	active site
335659005307	substrate pocket [chemical binding]; other site
335659005308	dimer interface [polypeptide binding]; other site
335659005309	proteolytic cleavage site; other site
335659005310	TRAP-type C4-dicarboxylate transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: DctP; COG1638
335659005311	Bacterial extracellular solute-binding protein, family 7; Region: SBP_bac_7; cl15441
335659005312	Tripartite ATP-independent periplasmic transporters, DctQ component; Region: DctQ; pfam04290
335659005313	DctM-like transporters; Region: DctM; pfam06808
335659005314	TRAP-type C4-dicarboxylate transport system, large permease component [Carbohydrate transport and metabolism]; Region: DctQ; COG1593
335659005315	Putative D-isomer specific 2-hydroxyacid dehydrogenases; Region: 2-Hacid_dh_8; cd12167
335659005316	Lactate dehydrogenase and related dehydrogenases [Energy production and conversion / Coenzyme metabolism / General function prediction only]; Region: LdhA; COG1052
335659005317	putative ligand binding site [chemical binding]; other site
335659005318	putative NAD binding site [chemical binding]; other site
335659005319	catalytic site [active]
335659005320	Type I periplasmic binding domain of uncharacterized extracellular ligand-binding proteins; Region: PBP1_STKc_like; cd06326
335659005321	Periplasmic binding protein; Region: Peripla_BP_6; pfam13458
335659005322	putative ligand binding site [chemical binding]; other site
335659005323	CHASE domain; Region: CHASE; pfam03924
335659005324	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
335659005325	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
335659005326	metal binding site [ion binding]; metal-binding site
335659005327	active site
335659005328	I-site; other site
335659005329	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
335659005330	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
335659005331	Major Facilitator Superfamily; Region: MFS_1; pfam07690
335659005332	putative substrate translocation pore; other site
335659005333	cyclic-di-GMP phosphodiesterase; Provisional; Region: PRK11359
335659005334	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
335659005335	putative active site [active]
335659005336	heme pocket [chemical binding]; other site
335659005337	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
335659005338	putative active site [active]
335659005339	heme pocket [chemical binding]; other site
335659005340	GAF domain; Region: GAF; pfam01590
335659005341	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
335659005342	metal binding site [ion binding]; metal-binding site
335659005343	active site
335659005344	I-site; other site
335659005345	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
335659005346	ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600
335659005347	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
335659005348	dimer interface [polypeptide binding]; other site
335659005349	conserved gate region; other site
335659005350	ABC-ATPase subunit interface; other site
335659005351	ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116
335659005352	ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293
335659005353	Walker A/P-loop; other site
335659005354	ATP binding site [chemical binding]; other site
335659005355	Q-loop/lid; other site
335659005356	ABC transporter signature motif; other site
335659005357	Walker B; other site
335659005358	D-loop; other site
335659005359	H-loop/switch region; other site
335659005360	ABC transporter, substrate-binding protein, aliphatic sulfonates family; Region: SsuA_fam; TIGR01728
335659005361	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cl17432
335659005362	membrane-bound complex binding site; other site
335659005363	hinge residues; other site
335659005364	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2258
335659005365	MOSC domain; Region: MOSC; pfam03473
335659005366	3-alpha domain; Region: 3-alpha; pfam03475
335659005367	Flavodoxin reductases (ferredoxin-NADPH reductases) family 1 [Energy production and conversion]; Region: Hmp; COG1018
335659005368	FAD_NAD(P)H binding domain of flavohemoglobin. Flavohemoglobins have a globin domain containing a B-type heme fused with a ferredoxin reductase-like FAD/NAD-binding domain. Flavohemoglobins detoxify nitric oxide (NO) via an NO dioxygenase reaction. The...; Region: flavohem_like_fad_nad_binding; cd06184
335659005369	FAD binding pocket [chemical binding]; other site
335659005370	FAD binding motif [chemical binding]; other site
335659005371	phosphate binding motif [ion binding]; other site
335659005372	beta-alpha-beta structure motif; other site
335659005373	NAD binding pocket [chemical binding]; other site
335659005374	Heme binding  pocket [chemical binding]; other site
335659005375	Ferredoxin [Energy production and conversion]; Region: Fdx; COG0633
335659005376	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
335659005377	catalytic loop [active]
335659005378	iron binding site [ion binding]; other site
335659005379	Predicted amidohydrolase [General function prediction only]; Region: COG0388
335659005380	Nitrilases, cyanide hydratase (CH)s, and similar proteins (class 1 nitrilases); Region: nitrilases_CHs; cd07564
335659005381	putative active site [active]
335659005382	catalytic triad [active]
335659005383	putative dimer interface [polypeptide binding]; other site
335659005384	Transcriptional regulator [Transcription]; Region: LysR; COG0583
335659005385	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
335659005386	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466
335659005387	dimerization interface [polypeptide binding]; other site
335659005388	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
335659005389	Major Facilitator Superfamily; Region: MFS_1; pfam07690
335659005390	putative substrate translocation pore; other site
335659005391	Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124
335659005392	Cytochrome P450; Region: p450; cl12078
335659005393	AsmA-like C-terminal region; Region: AsmA_2; pfam13502
335659005394	Uncharacterized protein conserved in bacteria (DUF2336); Region: DUF2336; pfam10098
335659005395	Cell division protein FtsL; Region: FtsL; cl11433
335659005396	Methyltransferase domain; Region: Methyltransf_23; pfam13489
335659005397	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
335659005398	S-adenosylmethionine binding site [chemical binding]; other site
335659005399	Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302
335659005400	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182
335659005401	Sulfite oxidase (SO) family, molybdopterin binding domain. This molybdopterin cofactor (Moco) binding domain is found in a variety of oxidoreductases, main members of this family are nitrate reductase (NR) and sulfite oxidase (SO). SO catalyzes the...; Region: SO_family_Moco; cl00199
335659005402	Moco binding site; other site
335659005403	metal coordination site [ion binding]; other site
335659005404	Cytochrome c; Region: Cytochrom_C; pfam00034
335659005405	Domain of unknown function DUF302; Region: DUF302; pfam03625
335659005406	ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683
335659005407	Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011
335659005408	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
335659005409	Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582
335659005410	TM-ABC transporter signature motif; other site
335659005411	ABC-type branched-chain amino acid transport system, permease component [Amino acid transport and metabolism]; Region: LivM; COG4177
335659005412	Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581
335659005413	TM-ABC transporter signature motif; other site
335659005414	ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411
335659005415	ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219
335659005416	Walker A/P-loop; other site
335659005417	ATP binding site [chemical binding]; other site
335659005418	Q-loop/lid; other site
335659005419	ABC transporter signature motif; other site
335659005420	Walker B; other site
335659005421	D-loop; other site
335659005422	H-loop/switch region; other site
335659005423	ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410
335659005424	ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224
335659005425	Walker A/P-loop; other site
335659005426	ATP binding site [chemical binding]; other site
335659005427	Q-loop/lid; other site
335659005428	ABC transporter signature motif; other site
335659005429	Walker B; other site
335659005430	D-loop; other site
335659005431	H-loop/switch region; other site
335659005432	pyrimidine utilization regulatory protein R; Region: RutR; TIGR03613
335659005433	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
335659005434	WHG domain; Region: WHG; pfam13305
335659005435	Uncharacterized protein containing double-stranded beta helix domain [Function unknown]; Region: COG4297
335659005436	hypothetical protein; Provisional; Region: PRK07236
335659005437	FAD dependent oxidoreductase; Region: DAO; pfam01266
335659005438	ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314
335659005439	Fe2+ transport system protein B [Inorganic ion transport and metabolism]; Region: FeoB; COG0370
335659005440	Ferrous iron transport protein B (FeoB) family; Region: FeoB; cd01879
335659005441	G1 box; other site
335659005442	GTP/Mg2+ binding site [chemical binding]; other site
335659005443	Switch I region; other site
335659005444	G2 box; other site
335659005445	G3 box; other site
335659005446	Switch II region; other site
335659005447	G4 box; other site
335659005448	G5 box; other site
335659005449	Nucleoside recognition; Region: Gate; pfam07670
335659005450	Ferrous iron transport protein B C terminus; Region: FeoB_C; pfam07664
335659005451	Nucleoside recognition; Region: Gate; pfam07670
335659005452	Fe2+ transport system protein A [Inorganic ion transport and metabolism]; Region: FeoA; COG1918
335659005453	Ribbon-helix-helix domain; Region: RHH_4; pfam13467
335659005454	Domain of unknown function (DUF4169); Region: DUF4169; pfam13770
335659005455	fumarate hydratase; Reviewed; Region: fumC; PRK00485
335659005456	Class II fumarases; Region: Fumarase_classII; cd01362
335659005457	active site
335659005458	tetramer interface [polypeptide binding]; other site
335659005459	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3814
335659005460	Chromate transporter; Region: Chromate_transp; pfam02417
335659005461	Chromate transporter; Region: Chromate_transp; pfam02417
335659005462	Tripartite tricarboxylate transporter TctB family; Region: TctB; pfam07331
335659005463	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3333
335659005464	Tripartite tricarboxylate transporter family receptor; Region: TctC; cl17792
335659005465	thymidylate synthase; Reviewed; Region: thyA; PRK01827
335659005466	Thymidylate synthase and pyrimidine hydroxymethylase: Thymidylate synthase (TS) and deoxycytidylate hydroxymethylase (dCMP-HMase) are homologs that catalyze analogous alkylation of C5 of pyrimidine nucleotides. Both enzymes are involved in the...; Region: TS_Pyrimidine_HMase; cd00351
335659005467	dimerization interface [polypeptide binding]; other site
335659005468	active site
335659005469	Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302
335659005470	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
335659005471	Coenzyme A binding pocket [chemical binding]; other site
335659005472	Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5; Region: DHFR; cl17426
335659005473	Bacterial membrane protein N terminal; Region: HflK_N; pfam12221
335659005474	Band_7_HflK: The band 7 domain of flotillin (reggie) like proteins. This group includes proteins similar to prokaryotic HlfK (High frequency of lysogenization K). Although many members of the band 7 family are lipid raft associated, prokaryote plasma...; Region: Band_7_HflK; cd03404
335659005475	HflK protein; Region: hflK; TIGR01933
335659005476	FtsH protease regulator HflC; Provisional; Region: PRK11029
335659005477	Band_7_HflC: The band 7 domain of flotillin (reggie) like proteins. This group includes proteins similar to prokaryotic HlfC (High frequency of lysogenization C). Although many members of the band 7 family are lipid raft associated, prokaryote plasma...; Region: Band_7_HflC; cd03405
335659005478	Uncharacterized protein conserved in bacteria (DUF2065); Region: DUF2065; pfam09838
335659005479	periplasmic serine protease, Do/DeqQ family; Region: degP_htrA_DO; TIGR02037
335659005480	Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365
335659005481	PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987
335659005482	protein binding site [polypeptide binding]; other site
335659005483	PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987
335659005484	protein binding site [polypeptide binding]; other site
335659005485	Phosphoserine phosphatase [Amino acid transport and metabolism]; Region: SerB; COG0560
335659005486	haloacid dehalogenase-like hydrolase; Region: HAD; cl17202
335659005487	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
335659005488	motif II; other site
335659005489	tRNA delta(2)-isopentenylpyrophosphate transferase; Reviewed; Region: miaA; PRK00091
335659005490	tRNA delta(2)-isopentenylpyrophosphate transferase [Translation, ribosomal structure and biogenesis]; Region: MiaA; COG0324
335659005491	acetolactate synthase 3 catalytic subunit; Validated; Region: PRK09107
335659005492	Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035
335659005493	PYR/PP interface [polypeptide binding]; other site
335659005494	dimer interface [polypeptide binding]; other site
335659005495	TPP binding site [chemical binding]; other site
335659005496	Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205
335659005497	Thiamine pyrophosphate (TPP) family, Acetohydroxyacid synthase (AHAS) subfamily, TPP-binding module; composed of proteins similar to the large catalytic subunit of AHAS. AHAS catalyzes the condensation of two molecules of pyruvate to give the...; Region: TPP_AHAS; cd02015
335659005498	TPP-binding site [chemical binding]; other site
335659005499	dimer interface [polypeptide binding]; other site
335659005500	Threonine dehydratase [Amino acid transport and metabolism]; Region: IlvA; COG1171
335659005501	Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562
335659005502	tetramer interface [polypeptide binding]; other site
335659005503	pyridoxal 5'-phosphate binding site [chemical binding]; other site
335659005504	catalytic residue [active]
335659005505	acetolactate synthase 3 regulatory subunit; Reviewed; Region: ilvH; PRK11895
335659005506	N-terminal ACT domain of the Escherichia coli IlvH-like regulatory subunit of acetohydroxyacid synthase (AHAS); Region: ACT_AHAS; cd04878
335659005507	putative valine binding site [chemical binding]; other site
335659005508	dimer interface [polypeptide binding]; other site
335659005509	Small subunit of acetolactate synthase; Region: ALS_ss_C; pfam10369
335659005510	Methyltransferase domain; Region: Methyltransf_31; pfam13847
335659005511	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
335659005512	S-adenosylmethionine binding site [chemical binding]; other site
335659005513	O-acetylserine/cysteine export protein; Provisional; Region: PRK11453
335659005514	EamA-like transporter family; Region: EamA; pfam00892
335659005515	EamA-like transporter family; Region: EamA; pfam00892
335659005516	ketol-acid reductoisomerase; Provisional; Region: PRK05479
335659005517	Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvN; pfam07991
335659005518	Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvC; pfam01450
335659005519	17beta hydroxysteroid dehydrogenase-like, classical (c) SDRs; Region: 17beta-HSD-like_SDR_c; cd05374
335659005520	short chain dehydrogenase; Provisional; Region: PRK06914
335659005521	NADP binding site [chemical binding]; other site
335659005522	active site
335659005523	steroid binding site; other site
335659005524	Sulfatase; Region: Sulfatase; cl17466
335659005525	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
335659005526	dimer interface [polypeptide binding]; other site
335659005527	conserved gate region; other site
335659005528	putative PBP binding loops; other site
335659005529	ABC-ATPase subunit interface; other site
335659005530	Substrate binding domain of ABC-type glycine betaine transport system; Region: OpuAC; pfam04069
335659005531	The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cl01709
335659005532	ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116
335659005533	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
335659005534	Walker A/P-loop; other site
335659005535	ATP binding site [chemical binding]; other site
335659005536	Q-loop/lid; other site
335659005537	ABC transporter signature motif; other site
335659005538	Walker B; other site
335659005539	D-loop; other site
335659005540	H-loop/switch region; other site
335659005541	ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293
335659005542	ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116
335659005543	Walker A/P-loop; other site
335659005544	ATP binding site [chemical binding]; other site
335659005545	Q-loop/lid; other site
335659005546	ABC transporter signature motif; other site
335659005547	Walker B; other site
335659005548	D-loop; other site
335659005549	H-loop/switch region; other site
335659005550	ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600
335659005551	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
335659005552	dimer interface [polypeptide binding]; other site
335659005553	conserved gate region; other site
335659005554	putative PBP binding loops; other site
335659005555	ABC-ATPase subunit interface; other site
335659005556	Domain of unknown function (DUF305); Region: DUF305; cl17794
335659005557	PQQ-dependent catabolism-associated beta-propeller protein; Region: PQQ_ABC_repeats; TIGR03866
335659005558	40-residue YVTN family beta-propeller repeat; Region: beta_rpt_yvtn; TIGR02276
335659005559	40-residue YVTN family beta-propeller repeat; Region: beta_rpt_yvtn; TIGR02276
335659005560	RNA polymerase sigma factor; Provisional; Region: PRK12547
335659005561	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
335659005562	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
335659005563	DNA binding residues [nucleotide binding]
335659005564	Predicted transmembrane transcriptional regulator (anti-sigma factor) [Transcription]; Region: COG5662
335659005565	Mannose-6-phosphate isomerase [Carbohydrate transport and metabolism]; Region: {ManC}; COG0662
335659005566	ABC transporter, substrate-binding protein, aliphatic sulfonates family; Region: SsuA_fam; TIGR01728
335659005567	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
335659005568	substrate binding pocket [chemical binding]; other site
335659005569	membrane-bound complex binding site; other site
335659005570	hinge residues; other site
335659005571	ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683
335659005572	Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011
335659005573	ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411
335659005574	ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219
335659005575	Walker A/P-loop; other site
335659005576	ATP binding site [chemical binding]; other site
335659005577	Q-loop/lid; other site
335659005578	ABC transporter signature motif; other site
335659005579	Walker B; other site
335659005580	D-loop; other site
335659005581	H-loop/switch region; other site
335659005582	ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410
335659005583	ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224
335659005584	Walker A/P-loop; other site
335659005585	ATP binding site [chemical binding]; other site
335659005586	Q-loop/lid; other site
335659005587	ABC transporter signature motif; other site
335659005588	Walker B; other site
335659005589	D-loop; other site
335659005590	H-loop/switch region; other site
335659005591	Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582
335659005592	TM-ABC transporter signature motif; other site
335659005593	ABC-type branched-chain amino acid transport system, permease component [Amino acid transport and metabolism]; Region: LivM; COG4177
335659005594	Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581
335659005595	TM-ABC transporter signature motif; other site
335659005596	polyphosphate:nucleotide phosphotransferase, PPK2 family; Region: PPK2_rel_1; TIGR03709
335659005597	Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849
335659005598	Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668
335659005599	Mechanosensitive ion channel; Region: MS_channel; pfam00924
335659005600	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3181
335659005601	malate dehydrogenase; Provisional; Region: PRK13529
335659005602	Malic enzyme, N-terminal domain; Region: malic; pfam00390
335659005603	NAD(P) binding domain of malic enzyme (ME), subgroup 1; Region: NAD_bind_1_malic_enz; cd05312
335659005604	NAD(P) binding site [chemical binding]; other site
335659005605	Rare lipoprotein A (RlpA)-like double-psi beta-barrel; Region: DPBB_1; pfam03330
335659005606	Lipoproteins [Cell envelope biogenesis, outer membrane]; Region: RlpA; COG0797
335659005607	Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072
335659005608	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738
335659005609	Esterases and lipases (includes fungal lipases, cholinesterases, etc.)  These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312
335659005610	alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859
335659005611	substrate binding pocket [chemical binding]; other site
335659005612	Esterases and lipases (includes fungal lipases, cholinesterases, etc.)  These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312
335659005613	Carboxylesterase family; Region: COesterase; pfam00135
335659005614	substrate binding pocket [chemical binding]; other site
335659005615	catalytic triad [active]
335659005616	The Class III extradiol dioxygenase, 4,5-DOPA Dioxygenase, catalyzes the incorporation of both atoms of molecular oxygen into 4,5-dihydroxy-phenylalanine; Region: 45_DOPA_Dioxygenase; cd07363
335659005617	Catalytic LigB subunit of aromatic ring-opening dioxygenase; Region: LigB; pfam02900
335659005618	putative active site [active]
335659005619	metal binding site [ion binding]; metal-binding site
335659005620	Uncharacterized conserved protein [Function unknown]; Region: COG4095
335659005621	glycogen synthase; Provisional; Region: PRK14099
335659005622	This family is most closely related to the GT1 family of glycosyltransferases. Glycogen synthase catalyzes the formation and elongation of the alpha-1,4-glucose backbone using ADP-glucose, the second and key step of glycogen biosynthesis. This family...; Region: GT1_Glycogen_synthase_DULL1_like; cd03791
335659005623	ADP-binding pocket [chemical binding]; other site
335659005624	homodimer interface [polypeptide binding]; other site
335659005625	glucose-1-phosphate adenylyltransferase; Provisional; Region: glgC; PRK00725
335659005626	ADP-glucose pyrophosphorylase is involved in the biosynthesis of glycogen or starch; Region: ADP_Glucose_PP; cd02508
335659005627	ligand binding site; other site
335659005628	oligomer interface; other site
335659005629	Glucose-1-phosphate adenylyltransferase, C-terminal Left-handed parallel beta helix (LbH) domain: Glucose-1-phosphate adenylyltransferase is also known as ADP-glucose synthase or ADP-glucose pyrophosphorylase. It catalyzes the first committed and...; Region: LbH_G1P_AT_C; cd04651
335659005630	dimer interface [polypeptide binding]; other site
335659005631	N-terminal domain interface [polypeptide binding]; other site
335659005632	sulfate 1 binding site; other site
335659005633	Rare lipoprotein A (RlpA)-like double-psi beta-barrel; Region: DPBB_1; pfam03330
335659005634	Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673
335659005635	Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408
335659005636	Periplasmic binding protein; Region: Peripla_BP_6; pfam13458
335659005637	Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011
335659005638	Excinuclease ATPase subunit [DNA replication, recombination, and repair]; Region: UvrA; COG0178
335659005639	ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270
335659005640	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
335659005641	ABC transporter signature motif; other site
335659005642	Walker B; other site
335659005643	D-loop; other site
335659005644	H-loop/switch region; other site
335659005645	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
335659005646	Walker A/P-loop; other site
335659005647	ATP binding site [chemical binding]; other site
335659005648	Q-loop/lid; other site
335659005649	ABC transporter signature motif; other site
335659005650	Walker B; other site
335659005651	D-loop; other site
335659005652	H-loop/switch region; other site
335659005653	Periplasmic binding protein; Region: Peripla_BP_6; pfam13458
335659005654	Type I periplasmic ligand-binding domain of uncharacterized ABC (Atpase Binding Cassette)-type active transport systems that are predicted to be involved in uptake of amino acids, peptides, or inorganic ions; Region: PBP1_ABC_ligand_binding_like_10; cd06345
335659005655	putative ligand binding site [chemical binding]; other site
335659005656	ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411
335659005657	ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219
335659005658	Walker A/P-loop; other site
335659005659	ATP binding site [chemical binding]; other site
335659005660	Q-loop/lid; other site
335659005661	ABC transporter signature motif; other site
335659005662	Walker B; other site
335659005663	D-loop; other site
335659005664	H-loop/switch region; other site
335659005665	ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410
335659005666	ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224
335659005667	Walker A/P-loop; other site
335659005668	ATP binding site [chemical binding]; other site
335659005669	Q-loop/lid; other site
335659005670	ABC transporter signature motif; other site
335659005671	Walker B; other site
335659005672	D-loop; other site
335659005673	H-loop/switch region; other site
335659005674	ABC-type branched-chain amino acid transport system, permease component [Amino acid transport and metabolism]; Region: LivM; COG4177
335659005675	Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581
335659005676	TM-ABC transporter signature motif; other site
335659005677	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
335659005678	Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582
335659005679	TM-ABC transporter signature motif; other site
335659005680	Gluconolactonase [Carbohydrate transport and metabolism]; Region: COG3386
335659005681	2-isopropylmalate synthase; Validated; Region: PRK00915
335659005682	2-isopropylmalate synthase (IPMS), N-terminal catalytic TIM barrel domain; Region: DRE_TIM_IPMS; cd07940
335659005683	active site
335659005684	catalytic residues [active]
335659005685	metal binding site [ion binding]; metal-binding site
335659005686	LeuA allosteric (dimerisation) domain; Region: LeuA_dimer; smart00917
335659005687	TRAP-type C4-dicarboxylate transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: DctP; COG1638
335659005688	Bacterial extracellular solute-binding protein, family 7; Region: SBP_bac_7; pfam03480
335659005689	FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784
335659005690	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
335659005691	active site
335659005692	phosphorylation site [posttranslational modification]
335659005693	intermolecular recognition site; other site
335659005694	dimerization interface [polypeptide binding]; other site
335659005695	RNA polymerase sigma factor; Provisional; Region: PRK12514
335659005696	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
335659005697	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
335659005698	DNA binding residues [nucleotide binding]
335659005699	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2343
335659005700	Putative lysophospholipase; Region: Hydrolase_4; pfam12146
335659005701	Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695
335659005702	Protein of unknown function (DUF3422); Region: DUF3422; pfam11902
335659005703	Hydroxymethylbilane synthase (HMBS), also known as porphobilinogen deaminase (PBGD), is an intermediate enzyme in the biosynthetic pathway of tetrapyrrolic ring systems, such as heme, chlorophylls, and vitamin B12. HMBS catalyzes the conversion of...; Region: HMBS; cl17708
335659005704	porphobilinogen deaminase; Reviewed; Region: hemC; PRK00072
335659005705	domain interfaces; other site
335659005706	active site
335659005707	magnesium chelatase ATPase subunit I; Region: BchI-ChlI; TIGR02030
335659005708	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
335659005709	Walker A motif; other site
335659005710	ATP binding site [chemical binding]; other site
335659005711	Walker B motif; other site
335659005712	arginine finger; other site
335659005713	magnesium chelatase subunit D; Provisional; Region: bchD; PRK13406
335659005714	Magnesium chelatase: Mg-chelatase catalyses the insertion of Mg into protoporphyrin IX (Proto). In chlorophyll biosynthesis, insertion of Mg2+ into protoporphyrin IX is catalysed by magnesium chelatase in an ATP-dependent reaction. Magnesium chelatase is...; Region: vWA_Magnesium_chelatase; cd01451
335659005715	metal ion-dependent adhesion site (MIDAS); other site
335659005716	Uroporphyrinogen decarboxylase (URO-D) is a dimeric cytosolic enzyme that decarboxylates the four acetate side chains of uroporphyrinogen III (uro-III) to create coproporphyrinogen III, without requiring any prosthetic groups or cofactors. This reaction...; Region: URO-D; cd00717
335659005717	substrate binding site [chemical binding]; other site
335659005718	active site
335659005719	Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596
335659005720	putative magnesium chelatase accessory protein; Region: bchO_mg_che_rel; TIGR03056
335659005721	phytoene desaturase; Region: crtI_fam; TIGR02734
335659005722	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
335659005723	Trans-Isoprenyl Diphosphate Synthases, head-to-head; Region: Trans_IPPS_HH; cd00683
335659005724	active site lid residues [active]
335659005725	substrate binding pocket [chemical binding]; other site
335659005726	catalytic residues [active]
335659005727	substrate-Mg2+ binding site; other site
335659005728	aspartate-rich region 1; other site
335659005729	aspartate-rich region 2; other site
335659005730	Coproporphyrinogen III oxidase [Coenzyme metabolism]; Region: HemF; COG0408
335659005731	Coproporphyrinogen III oxidase; Region: Coprogen_oxidas; cl17752
335659005732	Hydroxyneurosporene synthase (CrtC); Region: CrtC; pfam07143
335659005733	phytoene desaturase; Region: crtI_fam; TIGR02734
335659005734	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
335659005735	Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685
335659005736	substrate binding pocket [chemical binding]; other site
335659005737	chain length determination region; other site
335659005738	substrate-Mg2+ binding site; other site
335659005739	catalytic residues [active]
335659005740	aspartate-rich region 1; other site
335659005741	active site lid residues [active]
335659005742	aspartate-rich region 2; other site
335659005743	C-20 methyltransferase BchU; Region: C20_methyl_CrtF; TIGR02716
335659005744	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
335659005745	S-adenosylmethionine binding site [chemical binding]; other site
335659005746	2-desacetyl-2-hydroxyethyl bacteriochlorophyllide A dehydrogenase; Region: bchC; TIGR01202
335659005747	2-desacetyl-2-hydroxyethyl bacteriochlorophyllide and other MDR family members; Region: 2-desacetyl-2-hydroxyethyl_bacteriochlorophyllide_; cd08255
335659005748	putative NAD(P) binding site [chemical binding]; other site
335659005749	The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203
335659005750	chlorophyllide reductase iron protein subunit X; Region: BchX; TIGR02016
335659005751	Chlide_reductase_Y : Y subunit of chlorophyllide (chlide) reductase (BchY).  Chlide reductase participates in photosynthetic pigment synthesis playing a role in the conversion of chlorophylls(Chl) into bacteriochlorophylls (BChl). Chlide reductase...; Region: Chlide_reductase_Y; cd01980
335659005752	chlorophyllide reductase subunit Y; Region: BchY; TIGR02015
335659005753	The nitrogenase enzyme system catalyzes the ATP-dependent reduction of dinitrogen to ammonia.  This group contains both alpha and beta subunits of component 1 of the three known genetically distinct types of nitrogenase systems: a molybdenum-dependent; Region: Oxidoreductase_nitrogenase; cl02775
335659005754	chlorophyllide reductase subunit Z; Region: BchZ; TIGR02014
335659005755	Proto-chlorophyllide reductase 57 kD subunit; Region: PCP_red; pfam08369
335659005756	Antenna complex alpha/beta subunit; Region: LHC; pfam00556
335659005757	Antenna complex alpha/beta subunit; Region: LHC; pfam00556
335659005758	Subunit L of bacterial photosynthetic reaction center; Region: Photo-RC_L; cd09290
335659005759	subunit M interface; other site
335659005760	subunit H interface; other site
335659005761	quinone binding site; other site
335659005762	bacteriopheophytin binding site; other site
335659005763	bacteriochlorophyll binding site; other site
335659005764	cytochrome C subunit interface; other site
335659005765	Fe binding site [ion binding]; other site
335659005766	Subunit M of bacterial photosynthetic reaction center; Region: Photo-RC_M; cd09291
335659005767	subunit H interface; other site
335659005768	subunit L interface; other site
335659005769	bacteriopheophytin binding site; other site
335659005770	carotenoid binding site; other site
335659005771	bacteriochlorophyll binding site; other site
335659005772	cytochrome C interface; other site
335659005773	quinone binding site; other site
335659005774	Fe binding site [ion binding]; other site
335659005775	transcriptional regulator PpsR; Region: PpsR-CrtJ; TIGR02040
335659005776	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
335659005777	putative active site [active]
335659005778	heme pocket [chemical binding]; other site
335659005779	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459
335659005780	putative active site [active]
335659005781	heme pocket [chemical binding]; other site
335659005782	Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954
335659005783	4-hydroxybenzoate polyprenyltransferase and related prenyltransferases [Coenzyme metabolism]; Region: UbiA; cl00337
335659005784	UbiA prenyltransferase family; Region: UbiA; pfam01040
335659005785	PUCC protein; Region: PUCC; pfam03209
335659005786	geranylgeranyl reductase; Region: BchP-ChlP; TIGR02023
335659005787	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
335659005788	TspO/MBR family; Region: TspO_MBR; pfam03073
335659005789	Cytochrome c; Region: Cytochrom_C; cl11414
335659005790	transcriptional regulator PpsR; Region: PpsR-CrtJ; TIGR02040
335659005791	PAS domain; Region: PAS; smart00091
335659005792	PAS domain; Region: PAS; smart00091
335659005793	putative active site [active]
335659005794	heme pocket [chemical binding]; other site
335659005795	Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954
335659005796	PAS fold; Region: PAS_2; pfam08446
335659005797	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
335659005798	GAF domain; Region: GAF; pfam01590
335659005799	Phytochrome region; Region: PHY; pfam00360
335659005800	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459
335659005801	PAS domain; Region: PAS_9; pfam13426
335659005802	putative active site [active]
335659005803	heme pocket [chemical binding]; other site
335659005804	Heme oxygenase catalyzes the rate limiting step in the degradation of heme to bilirubin, it is essential for recycling of iron from heme. Heme is used as a substrate and cofactor for its own degradation to biliverdin, iron, and carbon monoxide. This...; Region: HemeO; cd00232
335659005805	heme binding pocket [chemical binding]; other site
335659005806	heme ligand [chemical binding]; other site
335659005807	B12 binding domain; Region: B12-binding_2; pfam02607
335659005808	B12 binding domain (B12-BD). Most of the members bind different cobalamid derivates, like B12 (adenosylcobamide) or methylcobalamin or methyl-Co(III) 5-hydroxybenzimidazolylcobamide. This domain is found in several enzymes, such as glutamate mutase; Region: B12-binding_like; cd02065
335659005809	B12 binding site [chemical binding]; other site
335659005810	2-vinyl bacteriochlorophyllide hydratase (BCHF); Region: BCHF; pfam07284
335659005811	light-independent protochlorophyllide reductase subunit N; Provisional; Region: PRK02842
335659005812	light-independent protochlorophyllide reductase, N subunit; Region: DPOR_bchN; TIGR01279
335659005813	light-independent protochlorophyllide reductase subunit B; Provisional; Region: PRK02910
335659005814	Pchlide_reductase_B: B protein of the NB protein complex of Protochlorophyllide (Pchlide)_reductase. Pchlide reductase catalyzes the reductive formation of chlorophyllide (chlide) from protochlorophyllide (pchlide) during biosynthesis of chlorophylls and...; Region: Pchlide_reductase_B; cd01981
335659005815	Proto-chlorophyllide reductase 57 kD subunit; Region: PCP_red; pfam08369
335659005816	magnesium chelatase subunit H; Provisional; Region: bchH; PRK13405
335659005817	CobN subunit of cobaltochelatase, bchH and chlH subunits of magnesium chelatases, and similar proteins; Region: CobN_like; cd10150
335659005818	protochlorophyllide reductase iron-sulfur ATP-binding protein; Provisional; Region: chlL; PRK13185
335659005819	This family of proteins contains bchL and chlL. Protochlorophyllide reductase catalyzes the reductive formation of chlorophyllide from protochlorophyllide during biosynthesis of chlorophylls and bacteriochlorophylls. Three genes, bchL, bchN and bchB, are...; Region: Bchl_like; cd02032
335659005820	P-loop; other site
335659005821	Mg-protoporphyrin IX methyl transferase; Validated; Region: PRK07580
335659005822	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173
335659005823	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
335659005824	S-adenosylmethionine binding site [chemical binding]; other site
335659005825	Magnesium-protoporphyrin IX methyltransferase C-terminus; Region: Mg-por_mtran_C; pfam07109
335659005826	PUCC protein; Region: PUCC; pfam03209
335659005827	Photosynthetic reaction center (RC) complex, subunit H;  RC is an integral membrane protein-pigment complex which catalyzes light-induced reduction of ubiquinone to ubiquinol, generating a transmembrane electrochemical gradient of protons used to produce...; Region: PRCH; cl17581
335659005828	photosynthetic reaction center, subunit H, bacterial; Region: puhA; TIGR01150
335659005829	subunit M interaction residues [polypeptide binding]; other site
335659005830	subunit L interaction residues [polypeptide binding]; other site
335659005831	putative proton transfer pathway, P1; other site
335659005832	putative proton transfer pathway, P2; other site
335659005833	Bacterial PH domain; Region: DUF304; pfam03703
335659005834	putative photosynthetic complex assembly protein; Region: photo_alph_chp1; TIGR03054
335659005835	Aerobic Cyclase System Fe-containing subunit (ACSF), ferritin-like diiron-binding domain; Region: ACSF; cd01047
335659005836	diiron binding motif [ion binding]; other site
335659005837	Protein of unknown function (DUF3623); Region: DUF3623; cl11843
335659005838	pyridoxal phosphate-dependent acyltransferase, putative; Region: gly_Cac_T_rel; TIGR01825
335659005839	KBL_like; this family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to serine palmitoyltransferase (SPT), 5-aminolevulinate synthase (ALAS); Region: KBL_like; cd06454
335659005840	substrate-cofactor binding pocket; other site
335659005841	pyridoxal 5'-phosphate binding site [chemical binding]; other site
335659005842	catalytic residue [active]
335659005843	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
335659005844	dimerization interface [polypeptide binding]; other site
335659005845	decaheme c-type cytochrome, DmsE family; Region: decahem_SO; TIGR03508
335659005846	Doubled CXXCH motif (Paired_CXXCH_1); Region: Paired_CXXCH_1; pfam09699
335659005847	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
335659005848	binding surface
335659005849	TPR motif; other site
335659005850	TPR repeat; Region: TPR_11; pfam13414
335659005851	Protein of unknown function (DUF2721); Region: DUF2721; pfam11026
335659005852	Uncharacterized conserved protein [Function unknown]; Region: COG5361
335659005853	Protein of unknown function (DUF1254); Region: DUF1254; pfam06863
335659005854	Protein of unknown function (DUF1214); Region: DUF1214; cl08447
335659005855	Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119
335659005856	Sulfatase; Region: Sulfatase; pfam00884
335659005857	Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119
335659005858	Sulfatase; Region: Sulfatase; pfam00884
335659005859	Uncharacterized conserved protein [Function unknown]; Region: COG5361
335659005860	Protein of unknown function (DUF1254); Region: DUF1254; pfam06863
335659005861	Protein of unknown function (DUF1214); Region: DUF1214; pfam06742
335659005862	Putative MetA-pathway of phenol degradation; Region: Phenol_MetA_deg; cl01768
335659005863	Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596
335659005864	Putative lysophospholipase; Region: Hydrolase_4; pfam12146
335659005865	N-terminal domain of Sphingobium chlorophenolicum 2,6-dichloro-p-hydroquinone 1,2-dioxygenase (PcpA), and similar proteins; Region: PcpA_N_like; cd08346
335659005866	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
335659005867	Zn binding site [ion binding]; other site
335659005868	C-terminal domain of Sphingobium chlorophenolicum 2,6-dichloro-p-hydroquinone 1,2-dioxygenase (PcpA), and similar proteins; Region: PcpA_C_like; cd08347
335659005869	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
335659005870	Zn binding site [ion binding]; other site
335659005871	Transcriptional regulator [Transcription]; Region: LysR; COG0583
335659005872	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
335659005873	The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_10; cd08480
335659005874	putative effector binding pocket; other site
335659005875	putative dimerization interface [polypeptide binding]; other site
335659005876	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
335659005877	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
335659005878	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
335659005879	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
335659005880	Serine hydrolase; Region: Ser_hydrolase; cl17834
335659005881	Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596
335659005882	Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326
335659005883	Isochorismatase family; Region: Isochorismatase; pfam00857
335659005884	YcaC related amidohydrolases; E.coli YcaC is an homooctameric hydrolase with unknown specificity. Despite its weak sequence similarity, it is structurally related to other amidohydrolases and shares conserved active site residues with them; Region: YcaC_related; cd01012
335659005885	catalytic triad [active]
335659005886	dimer interface [polypeptide binding]; other site
335659005887	conserved cis-peptide bond; other site
335659005888	Protein of unknown function (DUF1427); Region: DUF1427; pfam07235
335659005889	Predicted metal-dependent hydrolase with the TIM-barrel fold [General function prediction only]; Region: COG1574
335659005890	YtcJ_like metal dependent amidohydrolases. YtcJ is a Bacillus subtilis ORF of unknown function. The Arabidopsis homolog LAF3 has been identified as a factor required for photochrome A signalling; Region: YtcJ_like; cd01300
335659005891	active site
335659005892	Predicted membrane protein [Function unknown]; Region: COG2259
335659005893	SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cl01053
335659005894	Domain of unknown function (DUF4104); Region: DUF4104; pfam13372
335659005895	Protein of unknown function (DUF1275); Region: DUF1275; pfam06912
335659005896	Tripartite tricarboxylate transporter family receptor; Region: TctC; cl17792
335659005897	Bacillus subtilis YkuE and related proteins, C-terminal metallophosphatase domain; Region: MPP_YkuE_C; cd07385
335659005898	Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149
335659005899	putative active site [active]
335659005900	putative metal binding site [ion binding]; other site
335659005901	Choline dehydrogenase and related flavoproteins [Amino acid transport and metabolism]; Region: BetA; COG2303
335659005902	GMC oxidoreductase; Region: GMC_oxred_C; pfam05199
335659005903	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
335659005904	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
335659005905	active site
335659005906	Tripartite tricarboxylate transporter family receptor; Region: TctC; cl17792
335659005907	Transcriptional regulators [Transcription]; Region: GntR; COG1802
335659005908	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
335659005909	DNA-binding site [nucleotide binding]; DNA binding site
335659005910	FCD domain; Region: FCD; pfam07729
335659005911	Short-chain alcohol dehydrogenase of unknown specificity [General function prediction only]; Region: COG4221
335659005912	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
335659005913	NAD(P) binding site [chemical binding]; other site
335659005914	active site
335659005915	3-hydroxybutyrate dehydrogenase; Provisional; Region: PRK12429
335659005916	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
335659005917	NAD(P) binding site [chemical binding]; other site
335659005918	active site
335659005919	Carboxymuconolactone decarboxylase family; Region: CMD; cl00460
335659005920	Periplasmic binding protein; Region: Peripla_BP_6; pfam13458
335659005921	Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011
335659005922	Periplasmic binding protein; Region: Peripla_BP_6; pfam13458
335659005923	Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011
335659005924	ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410
335659005925	ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224
335659005926	Walker A/P-loop; other site
335659005927	ATP binding site [chemical binding]; other site
335659005928	Q-loop/lid; other site
335659005929	ABC transporter signature motif; other site
335659005930	Walker B; other site
335659005931	D-loop; other site
335659005932	H-loop/switch region; other site
335659005933	ABC-type branched-chain amino acid transport system, permease component [Amino acid transport and metabolism]; Region: LivM; COG4177
335659005934	Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581
335659005935	TM-ABC transporter signature motif; other site
335659005936	ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411
335659005937	ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219
335659005938	Walker A/P-loop; other site
335659005939	ATP binding site [chemical binding]; other site
335659005940	Q-loop/lid; other site
335659005941	ABC transporter signature motif; other site
335659005942	Walker B; other site
335659005943	D-loop; other site
335659005944	H-loop/switch region; other site
335659005945	Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582
335659005946	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
335659005947	TM-ABC transporter signature motif; other site
335659005948	MmgE/PrpD family; Region: MmgE_PrpD; cl00912
335659005949	3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084
335659005950	6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599
335659005951	Uncharacterized protein involved in propionate catabolism [General function prediction only]; Region: PrpD; COG2079
335659005952	Carboxymuconolactone decarboxylase family; Region: CMD; cl00460
335659005953	Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849
335659005954	Transcriptional regulators [Transcription]; Region: GntR; COG1802
335659005955	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
335659005956	DNA-binding site [nucleotide binding]; DNA binding site
335659005957	This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895
335659005958	ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components [Inorganic ion transport and metabolism]; Region: TauA; COG0715
335659005959	ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600
335659005960	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
335659005961	dimer interface [polypeptide binding]; other site
335659005962	conserved gate region; other site
335659005963	putative PBP binding loops; other site
335659005964	ABC-ATPase subunit interface; other site
335659005965	ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116
335659005966	ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293
335659005967	Walker A/P-loop; other site
335659005968	ATP binding site [chemical binding]; other site
335659005969	Q-loop/lid; other site
335659005970	ABC transporter signature motif; other site
335659005971	Walker B; other site
335659005972	D-loop; other site
335659005973	H-loop/switch region; other site
335659005974	ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600
335659005975	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
335659005976	dimer interface [polypeptide binding]; other site
335659005977	conserved gate region; other site
335659005978	ABC-ATPase subunit interface; other site
335659005979	Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726
335659005980	Catalytic NodB homology domain of rhizobial NodB-like proteins; Region: CE4_NodB_like_6s_7s; cd10917
335659005981	NodB motif; other site
335659005982	active site
335659005983	catalytic site [active]
335659005984	metal binding site [ion binding]; metal-binding site
335659005985	2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179
335659005986	Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557
335659005987	methionine synthase; Provisional; Region: PRK01207
335659005988	CIMS - Cobalamine-independent methonine synthase, or MetE, C-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_C_terminal_like; cd03311
335659005989	substrate binding site [chemical binding]; other site
335659005990	THF binding site; other site
335659005991	zinc-binding site [ion binding]; other site
335659005992	This group of proteins belong to a large family of YjgF/YER057c/UK114-like proteins present in bacteria, archaea, and eukaryotes with no definitive function.  The conserved domain is similar in structure to chorismate mutase but there is no sequence...; Region: YjgF_YER057c_UK114_like_2; cd06150
335659005993	homotrimer interaction site [polypeptide binding]; other site
335659005994	putative active site [active]
335659005995	The MopB_DMSOR-BSOR-TMAOR CD contains dimethylsulfoxide reductase (DMSOR), biotin sulfoxide reductase (BSOR),  trimethylamine N-oxide reductase (TMAOR) and other related proteins. DMSOR always catalyzes the reduction of DMSO to dimethylsulfide, but its...; Region: MopB_DMSOR-BSOR-TMAOR; cd02769
335659005996	molybdopterin guanine dinucleotide-containing S/N-oxide reductases; Region: bisC_fam; TIGR00509
335659005997	molybdopterin cofactor binding site [chemical binding]; other site
335659005998	substrate binding site [chemical binding]; other site
335659005999	The MopB_DMSOR-BSOR-TMAOR CD contains dimethylsulfoxide reductase (DMSOR), biotin sulfoxide reductase (BSOR),  trimethylamine N-oxide reductase (TMAOR) and other related proteins. DMSOR always catalyzes the reduction of DMSO to dimethylsulfide, but its...; Region: MopB_CT_DMSOR-BSOR-TMAOR; cd02793
335659006000	molybdopterin cofactor binding site; other site
335659006001	DNA-binding ferritin-like protein (oxidative damage protectant) [Inorganic ion transport and metabolism]; Region: Dps; COG0783
335659006002	DPS protein, ferritin-like diiron-binding domain; Region: DPS; cd01043
335659006003	dimerization interface [polypeptide binding]; other site
335659006004	DPS ferroxidase diiron center [ion binding]; other site
335659006005	ion pore; other site
335659006006	AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207
335659006007	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
335659006008	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
335659006009	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
335659006010	DNA binding site [nucleotide binding]
335659006011	Predicted ATPase [General function prediction only]; Region: COG3903
335659006012	Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596
335659006013	Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596
335659006014	Putative lysophospholipase; Region: Hydrolase_4; pfam12146
335659006015	Type 1 glutamine amidotransferase (GATase1)-like domain found in proteins similar to Escherichia coli Hsp31 protein; Region: GATase1_Hsp31_like; cd03141
335659006016	Putative intracellular protease/amidase [General function prediction only]; Region: ThiJ; COG0693
335659006017	potential catalytic triad [active]
335659006018	conserved cys residue [active]
335659006019	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
335659006020	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
335659006021	DNA binding site [nucleotide binding]
335659006022	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189
335659006023	Predicted ATPase [General function prediction only]; Region: COG3903
335659006024	Walker A motif; other site
335659006025	ATP binding site [chemical binding]; other site
335659006026	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920
335659006027	Histidine kinase; Region: HisKA_2; pfam07568
335659006028	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
335659006029	ATP binding site [chemical binding]; other site
335659006030	Mg2+ binding site [ion binding]; other site
335659006031	G-X-G motif; other site
335659006032	This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_16; cd07263
335659006033	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
335659006034	Epoxide hydrolase N terminus; Region: EHN; pfam06441
335659006035	Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596
335659006036	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
335659006037	Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024
335659006038	substrate binding site [chemical binding]; other site
335659006039	oxyanion hole (OAH) forming residues; other site
335659006040	trimer interface [polypeptide binding]; other site
335659006041	peroxiredoxin, OsmC subfamily; Region: osmo_induc_OsmC; TIGR03562
335659006042	methionine sulfoxide reductase A; Provisional; Region: PRK14054
335659006043	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
335659006044	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
335659006045	Multidrug resistance efflux pump [Defense mechanisms]; Region: EmrA; COG1566
335659006046	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
335659006047	HlyD family secretion protein; Region: HlyD_3; pfam13437
335659006048	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
335659006049	Major Facilitator Superfamily; Region: MFS_1; pfam07690
335659006050	putative substrate translocation pore; other site
335659006051	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
335659006052	Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248
335659006053	active site
335659006054	catalytic tetrad [active]
335659006055	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
335659006056	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
335659006057	DNA binding site [nucleotide binding]
335659006058	Predicted ATPase [General function prediction only]; Region: COG3903
335659006059	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3181
335659006060	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
335659006061	dimerization interface [polypeptide binding]; other site
335659006062	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
335659006063	dimer interface [polypeptide binding]; other site
335659006064	phosphorylation site [posttranslational modification]
335659006065	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
335659006066	ATP binding site [chemical binding]; other site
335659006067	Mg2+ binding site [ion binding]; other site
335659006068	G-X-G motif; other site
335659006069	osmolarity response regulator; Provisional; Region: ompR; PRK09468
335659006070	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
335659006071	active site
335659006072	phosphorylation site [posttranslational modification]
335659006073	intermolecular recognition site; other site
335659006074	dimerization interface [polypeptide binding]; other site
335659006075	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
335659006076	DNA binding site [nucleotide binding]
335659006077	macrolide transporter ATP-binding /permease protein; Provisional; Region: PRK10535
335659006078	ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255
335659006079	Walker A/P-loop; other site
335659006080	ATP binding site [chemical binding]; other site
335659006081	Q-loop/lid; other site
335659006082	ABC transporter signature motif; other site
335659006083	Walker B; other site
335659006084	D-loop; other site
335659006085	H-loop/switch region; other site
335659006086	MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
335659006087	FtsX-like permease family; Region: FtsX; pfam02687
335659006088	macrolide transporter subunit MacA; Provisional; Region: PRK11578
335659006089	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
335659006090	HlyD family secretion protein; Region: HlyD_3; pfam13437
335659006091	type I secretion outer membrane protein, TolC family; Region: type_I_sec_TolC; TIGR01844
335659006092	Outer membrane protein/protective antigen OMA87 [Cell envelope biogenesis, outer membrane]; Region: COG4775
335659006093	Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244
335659006094	Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244
335659006095	Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244
335659006096	Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244
335659006097	Surface antigen; Region: Bac_surface_Ag; pfam01103
335659006098	allantoate amidohydrolase; Reviewed; Region: PRK12892
335659006099	M20 Peptidase beta-alanine synthase, an amidohydrolase; Region: M20_bAS; cd03884
335659006100	active site
335659006101	metal binding site [ion binding]; metal-binding site
335659006102	dimer interface [polypeptide binding]; other site
335659006103	ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116
335659006104	ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293
335659006105	Walker A/P-loop; other site
335659006106	ATP binding site [chemical binding]; other site
335659006107	Q-loop/lid; other site
335659006108	ABC transporter signature motif; other site
335659006109	Walker B; other site
335659006110	D-loop; other site
335659006111	H-loop/switch region; other site
335659006112	ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600
335659006113	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
335659006114	dimer interface [polypeptide binding]; other site
335659006115	conserved gate region; other site
335659006116	putative PBP binding loops; other site
335659006117	ABC-ATPase subunit interface; other site
335659006118	ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components [Inorganic ion transport and metabolism]; Region: TauA; COG0715
335659006119	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
335659006120	substrate binding pocket [chemical binding]; other site
335659006121	membrane-bound complex binding site; other site
335659006122	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
335659006123	DNA-binding site [nucleotide binding]; DNA binding site
335659006124	histidine utilization repressor, proteobacterial; Region: his_ut_repres; TIGR02018
335659006125	UTRA domain; Region: UTRA; pfam07702
335659006126	N-formimino-L-glutamate deiminase; Validated; Region: PRK09229
335659006127	Metallo-dependent hydrolases, subgroup D is part of the superfamily of metallo-dependent hydrolases, a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the...; Region: Met_dep_hydrolase_E; cd01313
335659006128	active site
335659006129	imidazolonepropionase; Validated; Region: PRK09356
335659006130	Imidazolonepropionase/imidazolone-5-propionate hydrolase (Imidazolone-5PH) catalyzes the third step in the histidine degradation pathway, the hydrolysis of (S)-3-(5-oxo-4,5-dihydro-3H-imidazol-4-yl)propanoate to N-formimidoyl-L-glutamate. In bacteria; Region: Imidazolone-5PH; cd01296
335659006131	active site
335659006132	Phenylalanine ammonia-lyase (PAL) and histidine ammonia-lyase (HAL); Region: PAL-HAL; cd00332
335659006133	active sites [active]
335659006134	tetramer interface [polypeptide binding]; other site
335659006135	urocanate hydratase; Provisional; Region: PRK05414
335659006136	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
335659006137	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
335659006138	FAD binding domain in molybdopterin dehydrogenase; Region: FAD_binding_5; pfam00941
335659006139	CO dehydrogenase flavoprotein C-terminal domain; Region: CO_deh_flav_C; smart01092
335659006140	4-hydroxybenzoyl-CoA reductase, gamma subunit; Region: 4hydroxCoAred; TIGR03193
335659006141	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
335659006142	catalytic loop [active]
335659006143	iron binding site [ion binding]; other site
335659006144	[2Fe-2S] binding domain; Region: Fer2_2; pfam01799
335659006145	Aerobic-type carbon monoxide dehydrogenase, large subunit CoxL/CutL homologs [Energy production and conversion]; Region: CoxL; COG1529
335659006146	Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; smart01008
335659006147	Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738
335659006148	Periplasmic binding protein; Region: Peripla_BP_6; pfam13458
335659006149	Periplasmic solute-binding domain of active transport proteins that belong to the type I periplasmic binding fold protein family; Region: PBP1_SBP_like_1; cd06327
335659006150	putative ligand binding site [chemical binding]; other site
335659006151	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
335659006152	Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582
335659006153	TM-ABC transporter signature motif; other site
335659006154	ABC-type branched-chain amino acid transport system, permease component [Amino acid transport and metabolism]; Region: LivM; COG4177
335659006155	Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581
335659006156	TM-ABC transporter signature motif; other site
335659006157	ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411
335659006158	ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219
335659006159	Walker A/P-loop; other site
335659006160	ATP binding site [chemical binding]; other site
335659006161	Q-loop/lid; other site
335659006162	ABC transporter signature motif; other site
335659006163	Walker B; other site
335659006164	D-loop; other site
335659006165	H-loop/switch region; other site
335659006166	ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410
335659006167	ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224
335659006168	Walker A/P-loop; other site
335659006169	ATP binding site [chemical binding]; other site
335659006170	Q-loop/lid; other site
335659006171	ABC transporter signature motif; other site
335659006172	Walker B; other site
335659006173	D-loop; other site
335659006174	H-loop/switch region; other site
335659006175	Predicted signal transduction protein containing a membrane domain, an EAL and a GGDEF domain [Signal transduction mechanisms]; Region: COG5001
335659006176	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
335659006177	metal binding site [ion binding]; metal-binding site
335659006178	active site
335659006179	I-site; other site
335659006180	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
335659006181	Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849
335659006182	Predicted hydrolase of the alpha/beta superfamily [General function prediction only]; Region: COG2819
335659006183	TonB-dependent Receptor Plug Domain; Region: Plug; pfam07715
335659006184	ABC-type tungstate transport system, permease component [Coenzyme metabolism]; Region: TupB; COG2998
335659006185	PBP superfamily domain; Region: PBP_like_2; pfam12849
335659006186	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427
335659006187	Mn2+ and Fe2+ transporters of the NRAMP family [Inorganic ion transport and metabolism]; Region: MntH; COG1914
335659006188	Natural resistance-associated macrophage protein; Region: Nramp; pfam01566
335659006189	Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665
335659006190	putative aminophosphonate oxidoreductase; Region: Phn_aa_oxid; TIGR03329
335659006191	Histidinol-phosphate/aromatic aminotransferase and cobyric acid decarboxylase [Amino acid transport and metabolism]; Region: HisC; COG0079
335659006192	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
335659006193	pyridoxal 5'-phosphate binding site [chemical binding]; other site
335659006194	homodimer interface [polypeptide binding]; other site
335659006195	catalytic residue [active]
335659006196	FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277
335659006197	FAD binding domain; Region: FAD_binding_4; pfam01565
335659006198	3-hydroxybutyryl-CoA dehydrogenase; Validated; Region: PRK05808
335659006199	3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737
335659006200	3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725
335659006201	Truncated hemoglobins (trHbs) are a family of oxygen-binding heme proteins found in cyanobacteria, eubacteria, unicellular eukaryotes, and plants. The truncated hemoglobins have a characteristic two-over-two alpha helical folding pattern that is distinct...; Region: Trunc_globin; cd00454
335659006202	apolar tunnel; other site
335659006203	heme binding site [chemical binding]; other site
335659006204	dimerization interface [polypeptide binding]; other site
335659006205	Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cd03467
335659006206	iron-sulfur cluster [ion binding]; other site
335659006207	[2Fe-2S] cluster binding site [ion binding]; other site
335659006208	PQQ-dependent dehydrogenase, methanol/ethanol family; Region: PQQ_enz_alc_DH; TIGR03075
335659006209	Ethanol dehydrogenase, a bacterial quinoprotein (PQQ-dependent type I alcohol dehydrogenase); Region: PQQ_ADH_I; cd10277
335659006210	dimer interface [polypeptide binding]; other site
335659006211	Trp docking motif [polypeptide binding]; other site
335659006212	active site
335659006213	Protein of unknown function with HXXEE motif; Region: HXXEE; pfam13787
335659006214	Aerobic-type carbon monoxide dehydrogenase, large subunit CoxL/CutL homologs [Energy production and conversion]; Region: CoxL; COG1529
335659006215	Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; smart01008
335659006216	Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738
335659006217	Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738
335659006218	Aerobic-type carbon monoxide dehydrogenase, small subunit CoxS/CutS homologs [Energy production and conversion]; Region: CoxS; COG2080
335659006219	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
335659006220	catalytic loop [active]
335659006221	iron binding site [ion binding]; other site
335659006222	[2Fe-2S] binding domain; Region: Fer2_2; pfam01799
335659006223	glutathione-dependent formaldehyde-activating enzyme; Provisional; Region: PRK05417
335659006224	Zn-dependent alcohol dehydrogenases, class III [Energy production and conversion]; Region: AdhC; COG1062
335659006225	class III alcohol dehydrogenases; Region: alcohol_DH_class_III; cd08300
335659006226	substrate binding site [chemical binding]; other site
335659006227	catalytic Zn binding site [ion binding]; other site
335659006228	NAD binding site [chemical binding]; other site
335659006229	structural Zn binding site [ion binding]; other site
335659006230	dimer interface [polypeptide binding]; other site
335659006231	c-type cytochrome, methanol metabolism-related; Region: 4cys_cytochr; TIGR03874
335659006232	Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010
335659006233	PQQ-dependent dehydrogenase, methanol/ethanol family; Region: PQQ_enz_alc_DH; TIGR03075
335659006234	Large subunit of methanol dehydrogenase (moxF); Region: PQQ_MDH; cd10278
335659006235	Trp docking motif [polypeptide binding]; other site
335659006236	dimer interface [polypeptide binding]; other site
335659006237	active site
335659006238	small subunit binding site [polypeptide binding]; other site
335659006239	DNA-binding transcriptional activator FeaR; Provisional; Region: PRK09685
335659006240	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3181
335659006241	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
335659006242	Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497
335659006243	substrate binding pocket [chemical binding]; other site
335659006244	membrane-bound complex binding site; other site
335659006245	hinge residues; other site
335659006246	Cytochrome C oxidase, cbb3-type, subunit III; Region: Cytochrome_CBB3; pfam13442
335659006247	PQQ-dependent dehydrogenase, methanol/ethanol family; Region: PQQ_enz_alc_DH; TIGR03075
335659006248	Ethanol dehydrogenase, a bacterial quinoprotein (PQQ-dependent type I alcohol dehydrogenase); Region: PQQ_ADH_I; cd10277
335659006249	dimer interface [polypeptide binding]; other site
335659006250	Trp docking motif [polypeptide binding]; other site
335659006251	active site
335659006252	EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to...; Region: EFh; cl17302
335659006253	Ca2+ binding site [ion binding]; other site
335659006254	ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116
335659006255	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
335659006256	Walker A/P-loop; other site
335659006257	ATP binding site [chemical binding]; other site
335659006258	Q-loop/lid; other site
335659006259	ABC transporter signature motif; other site
335659006260	Walker B; other site
335659006261	D-loop; other site
335659006262	H-loop/switch region; other site
335659006263	ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600
335659006264	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
335659006265	dimer interface [polypeptide binding]; other site
335659006266	conserved gate region; other site
335659006267	putative PBP binding loops; other site
335659006268	ABC-ATPase subunit interface; other site
335659006269	ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components [Inorganic ion transport and metabolism]; Region: TauA; COG0715
335659006270	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
335659006271	TRAP transporter solute receptor, TAXI family; Region: TRAP_TAXI; TIGR02122
335659006272	Predicted secreted protein [Function unknown]; Region: COG5501
335659006273	Sulfur oxidation protein SoxY; Region: SoxY; pfam13501
335659006274	Sulphur oxidation protein SoxZ; Region: SoxZ; pfam08770
335659006275	Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849
335659006276	quinoprotein dehydrogenase-associated probable ABC transporter substrate-binding protein; Region: ABC_peri_MoxJ_2; TIGR03871
335659006277	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
335659006278	substrate binding pocket [chemical binding]; other site
335659006279	membrane-bound complex binding site; other site
335659006280	hinge residues; other site
335659006281	Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158
335659006282	active site residue [active]
335659006283	Copper binding periplasmic protein CusF; Region: CusF_Ec; cl02363
335659006284	ABC-2 type transporter; Region: ABC2_membrane; cl17235
335659006285	ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842
335659006286	ABC transporter, ATP-binding subunit, PQQ-dependent alcohol dehydrogenase system; Region: PQQ_ABC_ATP; TIGR03864
335659006287	First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225
335659006288	Walker A/P-loop; other site
335659006289	ATP binding site [chemical binding]; other site
335659006290	Q-loop/lid; other site
335659006291	ABC transporter signature motif; other site
335659006292	Walker B; other site
335659006293	D-loop; other site
335659006294	H-loop/switch region; other site
335659006295	PQQ-dependent catabolism-associated beta-propeller protein; Region: PQQ_ABC_repeats; TIGR03866
335659006296	40-residue YVTN family beta-propeller repeat; Region: beta_rpt_yvtn; TIGR02276
335659006297	40-residue YVTN family beta-propeller repeat; Region: beta_rpt_yvtn; TIGR02276
335659006298	40-residue YVTN family beta-propeller repeat; Region: beta_rpt_yvtn; TIGR02276
335659006299	ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683
335659006300	Periplasmic binding domain of ATP-binding cassette transporter-like systems that belong to the type I periplasmic binding fold protein superfamily; Region: PBP1_ABC_transporter_LIVBP_like; cd06268
335659006301	ligand binding site [chemical binding]; other site
335659006302	Protein of unknown function (DUF2380); Region: DUF3280; pfam11684
335659006303	S-formylglutathione hydrolase; Region: PLN02442
335659006304	S-formylglutathione hydrolase; Region: fghA_ester_D; TIGR02821
335659006305	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
335659006306	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
335659006307	active site
335659006308	phosphorylation site [posttranslational modification]
335659006309	intermolecular recognition site; other site
335659006310	dimerization interface [polypeptide binding]; other site
335659006311	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
335659006312	DNA binding residues [nucleotide binding]
335659006313	dimerization interface [polypeptide binding]; other site
335659006314	HAMP domain; Region: HAMP; pfam00672
335659006315	dimerization interface [polypeptide binding]; other site
335659006316	Histidine kinase; Region: HisKA_3; pfam07730
335659006317	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
335659006318	ATP binding site [chemical binding]; other site
335659006319	Mg2+ binding site [ion binding]; other site
335659006320	G-X-G motif; other site
335659006321	Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629
335659006322	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
335659006323	N-terminal plug; other site
335659006324	ligand-binding site [chemical binding]; other site
335659006325	Predicted dienelactone hydrolase [General function prediction only]; Region: COG4188
335659006326	Glycosyl hydrolase family 1; Region: Glyco_hydro_1; cl01046
335659006327	beta-galactosidase; Region: BGL; TIGR03356
335659006328	acetyl-CoA acetyltransferase; Provisional; Region: PRK06025
335659006329	Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751
335659006330	dimer interface [polypeptide binding]; other site
335659006331	active site
335659006332	Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591
335659006333	IHF dimer interface [polypeptide binding]; other site
335659006334	IHF - DNA interface [nucleotide binding]; other site
335659006335	ATP-dependent Lon protease, bacterial type [Posttranslational modification, protein turnover, chaperones]; Region: Lon; COG0466
335659006336	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
335659006337	Walker A motif; other site
335659006338	ATP binding site [chemical binding]; other site
335659006339	Walker B motif; other site
335659006340	arginine finger; other site
335659006341	Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362
335659006342	Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071
335659006343	Alpha-crystallin domain (ACD) of alpha-crystallin-type small(s) heat shock proteins (Hsps). sHsps are small stress induced proteins with monomeric masses between 12 -43 kDa, whose common feature is the Alpha-crystallin domain  (ACD). sHsps are generally...; Region: ACD_sHsps-like; cd06464
335659006344	putative dimer interface [polypeptide binding]; other site
335659006345	YciF bacterial stress response protein, ferritin-like iron-binding domain; Region: YciF; cd07909
335659006346	dimerization interface [polypeptide binding]; other site
335659006347	metal binding site [ion binding]; metal-binding site
335659006348	Multiple antibiotic transporter [Intracellular trafficking and secretion]; Region: MarC; COG2095
335659006349	Class II Aldolase and Adducin head (N-terminal) domain. Aldolases are ubiquitous enzymes catalyzing central steps of carbohydrate metabolism. Based on enzymatic mechanisms, this superfamily has been divided into two distinct classes (Class I and II); Region: Aldolase_II; cl00214
335659006350	intersubunit interface [polypeptide binding]; other site
335659006351	active site
335659006352	Zn2+ binding site [ion binding]; other site
335659006353	Chloride channel protein EriC [Inorganic ion transport and metabolism]; Region: EriC; COG0038
335659006354	CLC voltage-gated chloride channel. The ClC chloride channels catalyse the selective flow of Cl- ions across cell membranes, thereby regulating electrical excitation in skeletal muscle and the flow of salt and water across epithelial barriers. This...; Region: Voltage_gated_ClC; cd00400
335659006355	Cl- selectivity filter; other site
335659006356	Cl- binding residues [ion binding]; other site
335659006357	pore gating glutamate residue; other site
335659006358	dimer interface [polypeptide binding]; other site
335659006359	FOG: CBS domain [General function prediction only]; Region: COG0517
335659006360	The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354
335659006361	Protein of unknown function (DUF2798); Region: DUF2798; pfam11391
335659006362	Protein of unknown function (DUF3830); Region: DUF3830; pfam12903
335659006363	putative urate catabolism protein; Region: uraD_N-term-dom; TIGR03212
335659006364	Catalytic domain of bacterial PuuE allantoinases, Schizosaccharomyces pombe chitin deacetylase 1 (SpCDA1), and similar proteins; Region: CE4_PuuE_SpCDA1; cd10977
335659006365	active site
335659006366	catalytic site [active]
335659006367	tetramer interface [polypeptide binding]; other site
335659006368	OHCU decarboxylase; Region: UHCUDC; TIGR03164
335659006369	HIUase (5-hydroxyisourate hydrolase) catalyzes the second step in a three-step ureide pathway in which 5-hydroxyisourate (HIU), a product of the uricase (urate oxidase) reaction, is hydrolyzed to 2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline (OHCU); Region: TLP_HIUase; cd05822
335659006370	active site
335659006371	homotetramer interface [polypeptide binding]; other site
335659006372	Aerobic-type carbon monoxide dehydrogenase, small subunit CoxS/CutS homologs [Energy production and conversion]; Region: CoxS; COG2080
335659006373	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
335659006374	catalytic loop [active]
335659006375	iron binding site [ion binding]; other site
335659006376	[2Fe-2S] binding domain; Region: Fer2_2; pfam01799
335659006377	Aerobic-type carbon monoxide dehydrogenase, large subunit CoxL/CutL homologs [Energy production and conversion]; Region: CoxL; COG1529
335659006378	Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; smart01008
335659006379	Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738
335659006380	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM/CutM homologs [Energy production and conversion]; Region: CoxM; COG1319
335659006381	hydroxydechloroatrazine ethylaminohydrolase; Reviewed; Region: PRK08203
335659006382	TRZ/ATZ family contains enzymes from the atrazine degradation pathway and related hydrolases. Atrazine, a chlorinated herbizide, can be catabolized by a variety of different bacteria. The first three steps of the atrazine dehalogenation pathway are...; Region: ATZ_TRZ_like; cd01298
335659006383	active site
335659006384	putative substrate binding pocket [chemical binding]; other site
335659006385	Uncharacterized ABC-type transport system, periplasmic component/surface lipoprotein [General function prediction only]; Region: Med; COG1744
335659006386	Periplasmic binding domain of the basic membrane lipoprotein Med in Bacillus and its close homologs from other bacteria and Archaea; Region: PBP1_BmpA_Med_like; cd06353
335659006387	putative ligand binding site [chemical binding]; other site
335659006388	Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette; Region: TM_PBP1_transp_TpRbsC_like; cd06580
335659006389	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
335659006390	TM-ABC transporter signature motif; other site
335659006391	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
335659006392	Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette; Region: TM_PBP1_transp_TpRbsC_like; cd06580
335659006393	TM-ABC transporter signature motif; other site
335659006394	ABC-type uncharacterized transport systems, ATPase components [General function prediction only]; Region: COG3845
335659006395	First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216
335659006396	Walker A/P-loop; other site
335659006397	ATP binding site [chemical binding]; other site
335659006398	Q-loop/lid; other site
335659006399	ABC transporter signature motif; other site
335659006400	Walker B; other site
335659006401	D-loop; other site
335659006402	H-loop/switch region; other site
335659006403	Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215
335659006404	Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285
335659006405	nucleoside/Zn binding site; other site
335659006406	dimer interface [polypeptide binding]; other site
335659006407	catalytic motif [active]
335659006408	ABC-type uncharacterized transport systems, ATPase components [General function prediction only]; Region: COG3845
335659006409	First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216
335659006410	Walker A/P-loop; other site
335659006411	ATP binding site [chemical binding]; other site
335659006412	Q-loop/lid; other site
335659006413	ABC transporter signature motif; other site
335659006414	Walker B; other site
335659006415	D-loop; other site
335659006416	H-loop/switch region; other site
335659006417	Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215
335659006418	Isochorismatase family; Region: Isochorismatase; pfam00857
335659006419	Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cd00431
335659006420	catalytic triad [active]
335659006421	conserved cis-peptide bond; other site
335659006422	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
335659006423	Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette; Region: TM_PBP1_transp_TpRbsC_like; cd06580
335659006424	TM-ABC transporter signature motif; other site
335659006425	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
335659006426	Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette; Region: TM_PBP1_transp_TpRbsC_like; cd06580
335659006427	TM-ABC transporter signature motif; other site
335659006428	Uncharacterized ABC-type transport system, periplasmic component/surface lipoprotein [General function prediction only]; Region: Med; COG1744
335659006429	Periplasmic binding domain of the basic membrane lipoprotein Med in Bacillus and its close homologs from other bacteria and Archaea; Region: PBP1_BmpA_Med_like; cd06353
335659006430	putative ligand binding site [chemical binding]; other site
335659006431	allantoate amidohydrolase; Reviewed; Region: PRK12890
335659006432	M20 Peptidase beta-alanine synthase, an amidohydrolase; Region: M20_bAS; cd03884
335659006433	active site
335659006434	metal binding site [ion binding]; metal-binding site
335659006435	dimer interface [polypeptide binding]; other site
335659006436	C4-dicarboxylate transporter DctA; Reviewed; Region: PRK01663
335659006437	Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301
335659006438	Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086
335659006439	active site
335659006440	VWA domain containing CoxE-like protein; Region: VWA_CoxE; pfam05762
335659006441	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
335659006442	ATPases associated with a variety of cellular activities; Region: AAA; smart00382
335659006443	Walker A motif; other site
335659006444	ATP binding site [chemical binding]; other site
335659006445	Walker B motif; other site
335659006446	arginine finger; other site
335659006447	quinone oxidoreductase, NADPH-dependent; Provisional; Region: PRK10754
335659006448	Quinone oxidoreductase (QOR); Region: QOR2; cd05286
335659006449	NADP binding site [chemical binding]; other site
335659006450	dimer interface [polypeptide binding]; other site
335659006451	Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529
335659006452	Catalytic site [active]
335659006453	GcrA cell cycle regulator; Region: GcrA; cl11564
335659006454	phasin; Region: phasin_2; TIGR01985
335659006455	Cytochrome c; Region: Cytochrom_C; cl11414
335659006456	Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695
335659006457	Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596
335659006458	Hemolysin activation/secretion protein [Intracellular trafficking and secretion]; Region: FhaC; COG2831
335659006459	POTRA domain, ShlB-type; Region: POTRA_2; pfam08479
335659006460	Surface antigen; Region: Bac_surface_Ag; pfam01103
335659006461	FecR protein; Region: FecR; pfam04773
335659006462	CHASE2 domain; Region: CHASE2; pfam05226
335659006463	PAS domain S-box; Region: sensory_box; TIGR00229
335659006464	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
335659006465	putative active site [active]
335659006466	heme pocket [chemical binding]; other site
335659006467	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
335659006468	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
335659006469	metal binding site [ion binding]; metal-binding site
335659006470	active site
335659006471	I-site; other site
335659006472	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
335659006473	Arginase family; Region: Arginase; cd09989
335659006474	active site
335659006475	Mn binding site [ion binding]; other site
335659006476	oligomer interface [polypeptide binding]; other site
335659006477	Mandelate racemase (MR)-like subfamily of the enolase superfamily. Enzymes of this subgroup share three conserved carboxylate ligands for the essential divalent metal ion (usually Mg2+), two aspartates and a glutamate, and conserved catalytic residues; Region: MR_like; cd03316
335659006478	L-alanine-DL-glutamate epimerase and related enzymes of enolase superfamily [Cell envelope biogenesis, outer membrane / General function prediction only]; Region: COG4948
335659006479	active site pocket [active]
335659006480	Protein of unknown function (DUF3606); Region: DUF3606; pfam12244
335659006481	Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804
335659006482	CoA-transferase family III; Region: CoA_transf_3; pfam02515
335659006483	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
335659006484	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
335659006485	active site
335659006486	Flavin reductase like domain; Region: Flavin_Reduct; smart00903
335659006487	3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084
335659006488	6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599
335659006489	ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components [Inorganic ion transport and metabolism]; Region: TauA; COG0715
335659006490	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
335659006491	substrate binding pocket [chemical binding]; other site
335659006492	membrane-bound complex binding site; other site
335659006493	dihydroxy-acid dehydratase; Provisional; Region: PRK00911
335659006494	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
335659006495	ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293
335659006496	Walker A/P-loop; other site
335659006497	ATP binding site [chemical binding]; other site
335659006498	Q-loop/lid; other site
335659006499	ABC transporter signature motif; other site
335659006500	Walker B; other site
335659006501	D-loop; other site
335659006502	H-loop/switch region; other site
335659006503	ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600
335659006504	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
335659006505	dimer interface [polypeptide binding]; other site
335659006506	conserved gate region; other site
335659006507	putative PBP binding loops; other site
335659006508	ABC-ATPase subunit interface; other site
335659006509	ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600
335659006510	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427
335659006511	3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737
335659006512	3-hydroxybutyryl-CoA dehydrogenase; Validated; Region: PRK08269
335659006513	3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725
335659006514	NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210
335659006515	NAD/NADP octopine/nopaline dehydrogenase, alpha-helical domain; Region: Octopine_DH; pfam02317
335659006516	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
335659006517	long-chain-fatty-acid--CoA ligase; Validated; Region: PRK06187
335659006518	acyl-activating enzyme (AAE) consensus motif; other site
335659006519	AMP binding site [chemical binding]; other site
335659006520	active site
335659006521	CoA binding site [chemical binding]; other site
335659006522	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
335659006523	Acyl-CoA dehydrogenase, N-terminal domain; Region: Acyl-CoA_dh_N; pfam02771
335659006524	Acyl-CoA dehydrogenase; Region: ACAD; cd00567
335659006525	active site
335659006526	3-oxoadipate enol-lactonase; Region: protocat_pcaD; TIGR02427
335659006527	Uncharacterized protein family (UPF0227); Region: UPF0227; cl14886
335659006528	classical (c) SDRs; Region: SDR_c; cd05233
335659006529	NAD(P) binding site [chemical binding]; other site
335659006530	active site
335659006531	Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024
335659006532	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
335659006533	substrate binding site [chemical binding]; other site
335659006534	oxyanion hole (OAH) forming residues; other site
335659006535	trimer interface [polypeptide binding]; other site
335659006536	salicylyl-CoA 5-hydroxylase; Reviewed; Region: PRK08255
335659006537	hypothetical protein; Provisional; Region: PRK07236
335659006538	hypothetical protein; Provisional; Region: PRK07236
335659006539	Old yellow enzyme (OYE) YqjM-like FMN binding domain. YqjM is involved in the oxidative stress response of Bacillus subtilis.  Like the other OYE members, each monomer of YqjM contains FMN as a non-covalently bound cofactor and uses NADPH as a reducing...; Region: OYE_YqiM_FMN; cd02932
335659006540	active site
335659006541	FMN binding site [chemical binding]; other site
335659006542	substrate binding site [chemical binding]; other site
335659006543	homotetramer interface [polypeptide binding]; other site
335659006544	catalytic residue [active]
335659006545	hypothetical protein; Provisional; Region: PRK07538
335659006546	ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314
335659006547	Cupin domain; Region: Cupin_2; pfam07883
335659006548	Periplasmic binding protein; Region: Peripla_BP_6; pfam13458
335659006549	Type I periplasmic binding component of active transport systems that are predicted to be involved in 2-nitrobenzoic acid degradation pathway; Region: PBP1_Nba_like; cd06359
335659006550	putative ligand binding site [chemical binding]; other site
335659006551	helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347
335659006552	MarR family; Region: MarR; pfam01047
335659006553	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
335659006554	Acyl-coenzyme A synthetases/AMP-(fatty) acid ligases [Lipid metabolism]; Region: Acs; COG0365
335659006555	acyl-activating enzyme (AAE) consensus motif; other site
335659006556	AMP binding site [chemical binding]; other site
335659006557	active site
335659006558	CoA binding site [chemical binding]; other site
335659006559	YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448
335659006560	homotrimer interaction site [polypeptide binding]; other site
335659006561	putative active site [active]
335659006562	FOG: CBS domain [General function prediction only]; Region: COG0517
335659006563	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the BON (bacterial OsmY and nodulation domain) domain. BON is a putative phospholipid-binding domain found in a family of osmotic shock protection...; Region: CBS_pair_BON_assoc; cd04586
335659006564	FOG: CBS domain [General function prediction only]; Region: COG0517
335659006565	The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354
335659006566	Poly-beta-hydroxybutyrate polymerase N terminal; Region: PHBC_N; pfam12551
335659006567	poly(R)-hydroxyalkanoic acid synthase, class I; Region: PHA_synth_I; TIGR01838
335659006568	Poly-beta-hydroxybutyrate polymerase (PhaC) N-terminus; Region: PhaC_N; pfam07167
335659006569	The CHAD domain is an alpha-helical domain functionally associated with some members of the adenylate cyclase family; Region: CHAD; smart00880
335659006570	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2187
335659006571	AAA domain; Region: AAA_33; pfam13671
335659006572	Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates...; Region: NK; cl17190
335659006573	active site
335659006574	Zn-dependent alcohol dehydrogenases [General function prediction only]; Region: AdhP; COG1064
335659006575	Cinnamyl alcohol dehydrogenases (CAD); Region: CAD2; cd08298
335659006576	putative NAD(P) binding site [chemical binding]; other site
335659006577	putative substrate binding site [chemical binding]; other site
335659006578	catalytic Zn binding site [ion binding]; other site
335659006579	structural Zn binding site [ion binding]; other site
335659006580	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
335659006581	Ligand Binding Site [chemical binding]; other site
335659006582	Acyl-CoA synthetase (NDP forming) [Energy production and conversion]; Region: COG1042
335659006583	CoA binding domain; Region: CoA_binding_2; pfam13380
335659006584	Succinyl-CoA ligase like flavodoxin domain; Region: Succ_CoA_lig; pfam13607
335659006585	ATP-grasp domain; Region: ATP-grasp_5; pfam13549
335659006586	Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302
335659006587	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
335659006588	Coenzyme A binding pocket [chemical binding]; other site
335659006589	Bacterial protein of unknown function (DUF883); Region: DUF883; cl01888
335659006590	Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function; Region: STAS_SulP_like_sulfate_transporter; cd07042
335659006591	ABC-type transport system involved in resistance to organic solvents, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2B; COG0767
335659006592	Permease; Region: Permease; pfam02405
335659006593	ABC-type transport system involved in resistance to organic solvents, ATPase component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2A; COG1127
335659006594	ATP-binding cassette transport system involved in resistant to organic solvents; Region: ABC_Org_Solvent_Resistant; cd03261
335659006595	Walker A/P-loop; other site
335659006596	ATP binding site [chemical binding]; other site
335659006597	Q-loop/lid; other site
335659006598	ABC transporter signature motif; other site
335659006599	Walker B; other site
335659006600	D-loop; other site
335659006601	H-loop/switch region; other site
335659006602	ABC-type transport system involved in resistance to organic solvents, periplasmic component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2C; COG1463
335659006603	mce related protein; Region: MCE; pfam02470
335659006604	Protein of unknown function (DUF330); Region: DUF330; cl01135
335659006605	Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010
335659006606	Cytochrome c; Region: Cytochrom_C; pfam00034
335659006607	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
335659006608	ligand binding site [chemical binding]; other site
335659006609	flexible hinge region; other site
335659006610	helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092
335659006611	putative switch regulator; other site
335659006612	non-specific DNA interactions [nucleotide binding]; other site
335659006613	DNA binding site [nucleotide binding]
335659006614	sequence specific DNA binding site [nucleotide binding]; other site
335659006615	putative cAMP binding site [chemical binding]; other site
335659006616	cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664
335659006617	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
335659006618	ligand binding site [chemical binding]; other site
335659006619	flexible hinge region; other site
335659006620	Crp-like helix-turn-helix domain; Region: HTH_Crp_2; pfam13545
335659006621	Putative cyclase; Region: Cyclase; pfam04199
335659006622	TRAP-type C4-dicarboxylate transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: DctP; COG1638
335659006623	Bacterial extracellular solute-binding protein, family 7; Region: SBP_bac_7; pfam03480
335659006624	TRAP-type C4-dicarboxylate transport system, small permease component [Carbohydrate transport and metabolism]; Region: DctM; COG3090
335659006625	DctM-like transporters; Region: DctM; pfam06808
335659006626	TRAP-type C4-dicarboxylate transport system, large permease component [Carbohydrate transport and metabolism]; Region: DctQ; COG1593
335659006627	3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK07231
335659006628	classical (c) SDRs; Region: SDR_c; cd05233
335659006629	NAD(P) binding site [chemical binding]; other site
335659006630	active site
335659006631	Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531
335659006632	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199
335659006633	Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738
335659006634	Aerobic-type carbon monoxide dehydrogenase, large subunit CoxL/CutL homologs [Energy production and conversion]; Region: CoxL; COG1529
335659006635	Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; smart01008
335659006636	Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738
335659006637	Aerobic-type carbon monoxide dehydrogenase, large subunit CoxL/CutL homologs [Energy production and conversion]; Region: CoxL; COG1529
335659006638	Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738
335659006639	Aerobic-type carbon monoxide dehydrogenase, small subunit CoxS/CutS homologs [Energy production and conversion]; Region: CoxS; COG2080
335659006640	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
335659006641	catalytic loop [active]
335659006642	iron binding site [ion binding]; other site
335659006643	[2Fe-2S] binding domain; Region: Fer2_2; pfam01799
335659006644	Tripartite tricarboxylate transporter family receptor; Region: TctC; cl17792
335659006645	Anaerobic dehydrogenases, typically selenocysteine-containing [Energy production and conversion]; Region: BisC; COG0243
335659006646	The MopB_3 CD includes a group of related uncharacterized bacterial and archaeal molybdopterin-binding oxidoreductase-like domains with a putative N-terminal iron-sulfur [4Fe-4S] cluster binding site and molybdopterin cofactor binding site. These members...; Region: MopB_3; cd02766
335659006647	putative [4Fe-4S] binding site [ion binding]; other site
335659006648	putative molybdopterin cofactor binding site [chemical binding]; other site
335659006649	Molybdopterin-Binding, C-terminal (MopB_CT) domain of the MopB superfamily of proteins, a  large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum-...; Region: MopB_CT; cl09929
335659006650	molybdopterin cofactor binding site; other site
335659006651	Caspase domain; Region: Peptidase_C14; pfam00656
335659006652	TPR repeat; Region: TPR_11; pfam13414
335659006653	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
335659006654	binding surface
335659006655	TPR motif; other site
335659006656	TPR repeat; Region: TPR_11; pfam13414
335659006657	enoyl-CoA hydratase; Provisional; Region: PRK05995
335659006658	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
335659006659	substrate binding site [chemical binding]; other site
335659006660	oxyanion hole (OAH) forming residues; other site
335659006661	trimer interface [polypeptide binding]; other site
335659006662	Uncharacterized protein, possibly involved in utilization of glycolate and propanediol [General function prediction only]; Region: GlcG; COG3193
335659006663	FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277
335659006664	FAD binding domain; Region: FAD_binding_4; pfam01565
335659006665	Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247
335659006666	Alanine-glyoxylate aminotransferase (AGAT) family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to alanine-glyoxylate aminotransferase (AGAT); Region: AGAT_like; cd06451
335659006667	homodimer interface [polypeptide binding]; other site
335659006668	pyridoxal 5'-phosphate binding site [chemical binding]; other site
335659006669	catalytic residue [active]
335659006670	enoyl-CoA hydratase; Provisional; Region: PRK06144
335659006671	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
335659006672	substrate binding site [chemical binding]; other site
335659006673	oxyanion hole (OAH) forming residues; other site
335659006674	trimer interface [polypeptide binding]; other site
335659006675	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cl15762
335659006676	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3181
335659006677	Tripartite tricarboxylate transporter TctB family; Region: TctB; pfam07331
335659006678	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3333
335659006679	Opacity protein and related surface antigens [Cell envelope biogenesis, outer membrane]; Region: COG3637
335659006680	Opacity protein and related surface antigens [Cell envelope biogenesis, outer membrane]; Region: COG3637
335659006681	Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804
335659006682	CoA-transferase family III; Region: CoA_transf_3; pfam02515
335659006683	Predicted acyltransferases [Lipid metabolism]; Region: COG1835
335659006684	Zinc-dependent metalloprotease, serralysin_like subfamily. Serralysins and related proteases are important virulence factors in pathogenic bacteria. They may be secreted into the medium via a mechanism found in gram-negative bacteria, that does not...; Region: ZnMc_serralysin_like; cd04277
335659006685	active site
335659006686	Tryptophan-rich Synechocystis species C-terminal domain; Region: W_rich_C; pfam07483
335659006687	Tryptophan-rich Synechocystis species C-terminal domain; Region: W_rich_C; pfam07483
335659006688	Tryptophan-rich Synechocystis species C-terminal domain; Region: W_rich_C; pfam07483
335659006689	Tryptophan-rich Synechocystis species C-terminal domain; Region: W_rich_C; pfam07483
335659006690	G1P_cytidylyltransferase catalyzes the production of CDP-D-Glucose; Region: G1P_cytidylyltransferase; cd02524
335659006691	Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis/translation initiation factor 2B, gamma/epsilon subunits (eIF-2Bgamma/eIF-2Bepsilon) [Cell envelope biogenesis, outer membrane / Translation, ribosomal structure...; Region: GCD1; COG1208
335659006692	substrate binding site; other site
335659006693	CDP-glucose 4,6-dehydratase; Region: CDP_4_6_dhtase; TIGR02622
335659006694	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
335659006695	NAD(P) binding site [chemical binding]; other site
335659006696	active site
335659006697	Phosphotransferase enzyme family; Region: APH; pfam01636
335659006698	Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270
335659006699	Sulfotransferase domain; Region: Sulfotransfer_1; pfam00685
335659006700	Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451
335659006701	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
335659006702	NAD(P) binding site [chemical binding]; other site
335659006703	active site
335659006704	transketolase; Reviewed; Region: PRK05899
335659006705	Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012
335659006706	TPP-binding site [chemical binding]; other site
335659006707	dimer interface [polypeptide binding]; other site
335659006708	Transketolase, C-terminal subunit [Carbohydrate transport and metabolism]; Region: COG3958
335659006709	Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033
335659006710	PYR/PP interface [polypeptide binding]; other site
335659006711	dimer interface [polypeptide binding]; other site
335659006712	TPP binding site [chemical binding]; other site
335659006713	Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780
335659006714	Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463
335659006715	Bacterial DPM1_like enzymes are related to eukaryotic DPM1; Region: DPM1_like_bac; cd04187
335659006716	Ligand binding site; other site
335659006717	Putative Catalytic site; other site
335659006718	DXD motif; other site
335659006719	Aminoglycoside 3-N-acetyltransferase; Region: Antibiotic_NAT; cl01051
335659006720	Acyl carrier protein [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: AcpP; COG0236
335659006721	Predicted enzyme involved in methoxymalonyl-ACP biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: FkbH; COG3882
335659006722	Acid Phosphatase; Region: Acid_PPase; cl17256
335659006723	Methyltransferase domain; Region: Methyltransf_31; pfam13847
335659006724	Methyltransferase domain; Region: Methyltransf_11; pfam08241
335659006725	This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632
335659006726	active site
335659006727	metal binding site [ion binding]; metal-binding site
335659006728	Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326
335659006729	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
335659006730	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013
335659006731	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
335659006732	S-adenosylmethionine binding site [chemical binding]; other site
335659006733	Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WecE; COG0399
335659006734	3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616
335659006735	inhibitor-cofactor binding pocket; inhibition site
335659006736	pyridoxal 5'-phosphate binding site [chemical binding]; other site
335659006737	catalytic residue [active]
335659006738	Cupin domain; Region: Cupin_2; cl17218
335659006739	Glycosyl transferases group 1; Region: Glyco_trans_1_2; pfam13524
335659006740	Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673
335659006741	Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408
335659006742	Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894
335659006743	WcxM-like, Left-handed parallel beta-Helix (LbH) N-terminal domain: This group is composed of Xanthomonas campestris WcxM and proteins with similarity to the WcxM N-terminal domain. WcxM is thought to be bifunctional, catalyzing both the isomerization...; Region: LbH_WxcM_N_like; cd03358
335659006744	putative trimer interface [polypeptide binding]; other site
335659006745	putative active site [active]
335659006746	putative substrate binding site [chemical binding]; other site
335659006747	putative CoA binding site [chemical binding]; other site
335659006748	Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WecE; COG0399
335659006749	3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616
335659006750	inhibitor-cofactor binding pocket; inhibition site
335659006751	pyridoxal 5'-phosphate binding site [chemical binding]; other site
335659006752	catalytic residue [active]
335659006753	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
335659006754	This family is most closely related to the GT1 family of glycosyltransferases. wbuB in E. coli is involved in the biosynthesis of the O26 O-antigen.  It has been proposed to function as an N-acetyl-L-fucosamine (L-FucNAc) transferase; Region: GT1_wbuB_like; cd03794
335659006755	histidinol-phosphate phosphatase family domain; Region: Histidinol-ppas; TIGR01656
335659006756	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
335659006757	active site
335659006758	motif I; other site
335659006759	motif II; other site
335659006760	GDP-D-mannose dehydratase [Cell envelope biogenesis, outer membrane]; Region: Gmd; COG1089
335659006761	GDP-mannose 4,6 dehydratase, extended (e) SDRs; Region: GDP_MD_SDR_e; cd05260
335659006762	NADP-binding site; other site
335659006763	homotetramer interface [polypeptide binding]; other site
335659006764	substrate binding site [chemical binding]; other site
335659006765	homodimer interface [polypeptide binding]; other site
335659006766	active site
335659006767	GDP-fucose synthetase, extended (e) SDRs; Region: GDP_FS_SDR_e; cd05239
335659006768	GDP-4-keto-6-deoxymannose-3, 5-epimerase-4-reductase; Region: PLN02725
335659006769	NADP binding site [chemical binding]; other site
335659006770	active site
335659006771	putative substrate binding site [chemical binding]; other site
335659006772	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
335659006773	phenylacetate-CoA ligase; Region: PA_CoA_ligase; TIGR02155
335659006774	acyl-activating enzyme (AAE) consensus motif; other site
335659006775	active site
335659006776	AMP binding site [chemical binding]; other site
335659006777	CoA binding site [chemical binding]; other site
335659006778	dimerization interface [polypeptide binding]; other site
335659006779	AGE domain; N-acyl-D-glucosamine 2-epimerase domain; Responsible for intermediate epimerization during biosynthesis of N-acetylneuraminic acid. Catalytic mechanism is believed to be via nucleotide elimination and readdition and is ATP modulated. AGE is...; Region: AGE; cl00183
335659006780	putative active cleft [active]
335659006781	ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410
335659006782	ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224
335659006783	Walker A/P-loop; other site
335659006784	ATP binding site [chemical binding]; other site
335659006785	Q-loop/lid; other site
335659006786	ABC transporter signature motif; other site
335659006787	Walker B; other site
335659006788	D-loop; other site
335659006789	H-loop/switch region; other site
335659006790	Periplasmic binding protein; Region: Peripla_BP_6; pfam13458
335659006791	Type I periplasmic ligand-binding domain of uncharacterized ABC (ATPase Binding Cassette)-type active transport systems that are predicted to be involved in transport of amino acids, peptides, or inorganic ions; Region: PBP1_ABC_ligand_binding_like_1; cd06334
335659006792	putative ligand binding site [chemical binding]; other site
335659006793	ABC-type branched-chain amino acid transport system, permease component [Amino acid transport and metabolism]; Region: LivM; COG4177
335659006794	Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581
335659006795	TM-ABC transporter signature motif; other site
335659006796	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
335659006797	Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582
335659006798	TM-ABC transporter signature motif; other site
335659006799	Domain of unknown function, appears to be related to a diverse group of endonucleases; Region: Endonuclease_DUF559; cd01038
335659006800	putative active site [active]
335659006801	Long-chain acyl-CoA synthetases (AMP-forming) [Lipid metabolism]; Region: FAA1; COG1022
335659006802	Long-chain fatty acid CoA synthetases and Bubblegum-like very long-chain fatty acid CoA synthetases; Region: VL_LC_FACS_like; cd05907
335659006803	acyl-activating enzyme (AAE) consensus motif; other site
335659006804	putative AMP binding site [chemical binding]; other site
335659006805	putative active site [active]
335659006806	putative CoA binding site [chemical binding]; other site
335659006807	ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411
335659006808	ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219
335659006809	Walker A/P-loop; other site
335659006810	ATP binding site [chemical binding]; other site
335659006811	Q-loop/lid; other site
335659006812	ABC transporter signature motif; other site
335659006813	Walker B; other site
335659006814	D-loop; other site
335659006815	H-loop/switch region; other site
335659006816	cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664
335659006817	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
335659006818	ligand binding site [chemical binding]; other site
335659006819	flexible hinge region; other site
335659006820	Crp-like helix-turn-helix domain; Region: HTH_Crp_2; pfam13545
335659006821	non-specific DNA interactions [nucleotide binding]; other site
335659006822	DNA binding site [nucleotide binding]
335659006823	sequence specific DNA binding site [nucleotide binding]; other site
335659006824	putative cAMP binding site [chemical binding]; other site
335659006825	H+ Antiporter protein; Region: 2A0121; TIGR00900
335659006826	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
335659006827	Uroporphyrinogen-III synthase [Coenzyme metabolism]; Region: HemD; COG1587
335659006828	Uroporphyrinogen-III synthase (HemD) catalyzes the asymmetrical cyclization of tetrapyrrole (linear) to uroporphyrinogen-III, the fourth step in the biosynthesis of heme. This ubiquitous enzyme is present in eukaryotes, bacteria and archaea. Mutations in...; Region: HemD; cd06578
335659006829	active site
335659006830	formyltetrahydrofolate deformylase; Reviewed; Region: purU; PRK06027
335659006831	N-terminal ACT domain of formyltetrahydrofolate deformylase (F4HF-DF; formyltetrahydrofolate hydrolase); Region: ACT_F4HF-DF; cd04875
335659006832	Formyltetrahydrofolate deformylase (Formyl-FH4 hydrolase), C-terminal hydrolase domain; Region: FMT_core_Formyl-FH4-Hydrolase_C; cd08648
335659006833	putative active site [active]
335659006834	putative substrate binding site [chemical binding]; other site
335659006835	putative cosubstrate binding site; other site
335659006836	catalytic site [active]
335659006837	Periplasmic binding protein; Region: Peripla_BP_6; pfam13458
335659006838	Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011
335659006839	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
335659006840	Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582
335659006841	TM-ABC transporter signature motif; other site
335659006842	ABC-type branched-chain amino acid transport system, permease component [Amino acid transport and metabolism]; Region: LivM; COG4177
335659006843	Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581
335659006844	TM-ABC transporter signature motif; other site
335659006845	ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411
335659006846	ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219
335659006847	Walker A/P-loop; other site
335659006848	ATP binding site [chemical binding]; other site
335659006849	Q-loop/lid; other site
335659006850	ABC transporter signature motif; other site
335659006851	Walker B; other site
335659006852	D-loop; other site
335659006853	H-loop/switch region; other site
335659006854	ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410
335659006855	ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224
335659006856	Walker A/P-loop; other site
335659006857	ATP binding site [chemical binding]; other site
335659006858	Q-loop/lid; other site
335659006859	ABC transporter signature motif; other site
335659006860	Walker B; other site
335659006861	D-loop; other site
335659006862	H-loop/switch region; other site
335659006863	CIMS - Cobalamine-independent methonine synthase, or MetE, C-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_C_terminal_like; cd03311
335659006864	substrate binding site [chemical binding]; other site
335659006865	THF binding site; other site
335659006866	zinc-binding site [ion binding]; other site
335659006867	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
335659006868	TPR motif; other site
335659006869	TPR repeat; Region: TPR_11; pfam13414
335659006870	binding surface
335659006871	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
335659006872	binding surface
335659006873	TPR repeat; Region: TPR_11; pfam13414
335659006874	TPR motif; other site
335659006875	Caspase domain; Region: Peptidase_C14; pfam00656
335659006876	S-adenosylmethionine synthetase; Validated; Region: PRK05250
335659006877	S-adenosylmethionine synthetase, N-terminal domain; Region: S-AdoMet_synt_N; pfam00438
335659006878	S-adenosylmethionine synthetase, central domain; Region: S-AdoMet_synt_M; pfam02772
335659006879	S-adenosylmethionine synthetase, C-terminal domain; Region: S-AdoMet_synt_C; pfam02773
335659006880	S-adenosyl-L-homocysteine hydrolase; Provisional; Region: PRK05476
335659006881	S-Adenosylhomocysteine Hydrolase, NAD-binding and catalytic domains; Region: SAHH; cd00401
335659006882	homotetramer interface [polypeptide binding]; other site
335659006883	ligand binding site [chemical binding]; other site
335659006884	catalytic site [active]
335659006885	NAD binding site [chemical binding]; other site
335659006886	SnoaL-like domain; Region: SnoaL_2; pfam12680
335659006887	Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072
335659006888	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738
335659006889	Protein of unknown function (DUF1228); Region: DUF1228; pfam06779
335659006890	Uncharacterized protein, 4-oxalocrotonate tautomerase homolog [General function prediction only]; Region: COG1942
335659006891	active site 1 [active]
335659006892	dimer interface [polypeptide binding]; other site
335659006893	hexamer interface [polypeptide binding]; other site
335659006894	active site 2 [active]
335659006895	3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557
335659006896	classical (c) SDRs; Region: SDR_c; cd05233
335659006897	NAD(P) binding site [chemical binding]; other site
335659006898	active site
335659006899	Transcriptional regulator [Transcription]; Region: LysR; COG0583
335659006900	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
335659006901	The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_2; cd08471
335659006902	putative effector binding pocket; other site
335659006903	putative dimerization interface [polypeptide binding]; other site
335659006904	Aspartyl/asparaginyl beta-hydroxylase and related dioxygenases [Posttranslational modification, protein turnover, chaperones]; Region: COG3555
335659006905	Calcium/calmodulin dependent protein kinase II Association; Region: CaMKII_AD; cl17504
335659006906	SnoaL-like domain; Region: SnoaL_3; pfam13474
335659006907	2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179
335659006908	Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557
335659006909	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
335659006910	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
335659006911	ATP-binding cassette domain of the bacterial lipid flippase and related proteins, subfamily C; Region: ABCC_MsbA; cd03251
335659006912	Walker A/P-loop; other site
335659006913	ATP binding site [chemical binding]; other site
335659006914	Q-loop/lid; other site
335659006915	ABC transporter signature motif; other site
335659006916	Walker B; other site
335659006917	D-loop; other site
335659006918	H-loop/switch region; other site
335659006919	UDP-glucose 4-epimerase [Cell envelope biogenesis, outer membrane]; Region: GalE; COG1087
335659006920	UDP-glucose 4 epimerase, subgroup 1, extended (e) SDRs; Region: UDP_G4E_1_SDR_e; cd05247
335659006921	NAD binding site [chemical binding]; other site
335659006922	homodimer interface [polypeptide binding]; other site
335659006923	active site
335659006924	substrate binding site [chemical binding]; other site
335659006925	This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801
335659006926	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
335659006927	Protein of unknown function (DUF3429); Region: DUF3429; pfam11911
335659006928	bifunctional 3-demethylubiquinone-9 3-methyltransferase/ 2-octaprenyl-6-hydroxy phenol methylase; Provisional; Region: PRK05134
335659006929	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
335659006930	S-adenosylmethionine binding site [chemical binding]; other site
335659006931	Domain of unknown function (DUF1127); Region: DUF1127; pfam06568
335659006932	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
335659006933	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
335659006934	DNA binding site [nucleotide binding]
335659006935	Predicted integral membrane protein [Function unknown]; Region: COG5616
335659006936	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
335659006937	binding surface
335659006938	TPR repeat; Region: TPR_11; pfam13414
335659006939	TPR motif; other site
335659006940	Domain of unknown function (DUF897); Region: DUF897; cl01312
335659006941	Transcriptional regulator [Transcription]; Region: LysR; COG0583
335659006942	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
335659006943	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
335659006944	dimerization interface [polypeptide binding]; other site
335659006945	GTP cyclohydrolase I; Provisional; Region: folE; PRK09347
335659006946	active site
335659006947	Secreted and surface protein containing fasciclin-like repeats [Cell envelope biogenesis, outer membrane]; Region: COG2335
335659006948	Fasciclin domain; Region: Fasciclin; pfam02469
335659006949	ADP-heptose:LPS heptosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaF; COG0859
335659006950	Lipopolysaccharide heptosyltransferase is involved in the biosynthesis of lipooligosaccharide (LOS). Lipopolysaccharide (LPS) is a major component of the outer membrane of gram-negative bacteria. LPS heptosyltransferase transfers heptose molecules from...; Region: GT1_LPS_heptosyltransferase; cd03789
335659006951	putative active site [active]
335659006952	ADP-L-glycero-D-mannoheptose 6-epimerase (GME), extended (e) SDRs; Region: ADP_GME_SDR_e; cd05248
335659006953	ADP-L-glycero-D-manno-heptose-6-epimerase; Region: heptose_epim; TIGR02197
335659006954	NADP binding site [chemical binding]; other site
335659006955	homopentamer interface [polypeptide binding]; other site
335659006956	substrate binding site [chemical binding]; other site
335659006957	active site
335659006958	ADP-heptose synthase, bifunctional sugar kinase/adenylyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaE; COG2870
335659006959	RfaE encodes a bifunctional ADP-heptose synthase involved in the biosynthesis of the lipopolysaccharide (LPS) core precursor ADP-L-glycero-D-manno-heptose. LPS plays an important role in maintaining the structural integrity of the bacterial outer...; Region: RfaE_like; cd01172
335659006960	putative ribose interaction site [chemical binding]; other site
335659006961	putative ADP binding site [chemical binding]; other site
335659006962	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
335659006963	active site
335659006964	HIGH motif; other site
335659006965	nucleotide binding site [chemical binding]; other site
335659006966	Lipid A core - O-antigen ligase and related enzymes [Cell envelope biogenesis, outer membrane]; Region: RfaL; COG3307
335659006967	O-Antigen ligase; Region: Wzy_C; pfam04932
335659006968	Predicted nucleoside-diphosphate sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG1086
335659006969	UDP-Glcnac (UDP-linked N-acetylglucosamine) inverting 4,6-dehydratase, extended (e) SDRs; Region: UDP_invert_4-6DH_SDR_e; cd05237
335659006970	NAD(P) binding site [chemical binding]; other site
335659006971	homodimer interface [polypeptide binding]; other site
335659006972	substrate binding site [chemical binding]; other site
335659006973	active site
335659006974	This family is most closely related to the GT1 family of glycosyltransferases. wbuB in E. coli is involved in the biosynthesis of the O26 O-antigen.  It has been proposed to function as an N-acetyl-L-fucosamine (L-FucNAc) transferase; Region: GT1_wbuB_like; cd03794
335659006975	Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451
335659006976	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
335659006977	NAD(P) binding site [chemical binding]; other site
335659006978	active site
335659006979	UDP-N-acetylmuramyl pentapeptide phosphotransferase/UDP-N- acetylglucosamine-1-phosphate transferase [Cell envelope biogenesis, outer membrane]; Region: Rfe; COG0472
335659006980	The members of this subfamily catalyze the formation of a phosphodiester bond between a membrane-associated undecaprenyl-phosphate (Und-P) molecule and N-acetylhexosamine 1-phosphate, which is usually donated by a soluble UDP-N-acetylhexosamine precursor; Region: GT_WbpL_WbcO_like; cd06854
335659006981	Mg++ binding site [ion binding]; other site
335659006982	putative catalytic motif [active]
335659006983	putative substrate binding site [chemical binding]; other site
335659006984	Uncharacterized protein family (UPF0104); Region: UPF0104; pfam03706
335659006985	Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451
335659006986	UDP glucuronic acid epimerase, extended (e) SDRs; Region: UDP_GE_SDE_e; cd05253
335659006987	putative NAD(P) binding site [chemical binding]; other site
335659006988	active site
335659006989	putative substrate binding site [chemical binding]; other site
335659006990	mannose-1-phosphate guanylyltransferase/mannose-6-phosphate isomerase; Region: GMP_PMI; TIGR01479
335659006991	GDP-M1P_Guanylyltransferase catalyzes the formation of GDP-Mannose; Region: GDP-M1P_Guanylyltransferase; cd02509
335659006992	Substrate binding site; other site
335659006993	Mannose-6-phosphate isomerase; Region: MannoseP_isomer; pfam01050
335659006994	Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673
335659006995	Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408
335659006996	Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894
335659006997	Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WecE; COG0399
335659006998	3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616
335659006999	inhibitor-cofactor binding pocket; inhibition site
335659007000	pyridoxal 5'-phosphate binding site [chemical binding]; other site
335659007001	catalytic residue [active]
335659007002	Uncharacterized membrane protein, putative virulence factor [General function prediction only]; Region: MviN; COG0728
335659007003	MurJ/MviN, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_MurJ_like; cd13123
335659007004	Domain of unknown function (DUF1127); Region: DUF1127; pfam06568
335659007005	Aerobic-type carbon monoxide dehydrogenase, large subunit CoxL/CutL homologs [Energy production and conversion]; Region: CoxL; COG1529
335659007006	Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; smart01008
335659007007	Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738
335659007008	Cytochrome C' Region: Cytochrom_C_2; pfam01322
335659007009	methionine gamma-lyase; Validated; Region: PRK07049
335659007010	CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614
335659007011	homodimer interface [polypeptide binding]; other site
335659007012	substrate-cofactor binding pocket; other site
335659007013	pyridoxal 5'-phosphate binding site [chemical binding]; other site
335659007014	catalytic residue [active]
335659007015	Methyltransferase domain; Region: Methyltransf_31; pfam13847
335659007016	Methyltransferase domain; Region: Methyltransf_24; pfam13578
335659007017	CHRD domain; Region: CHRD; pfam07452
335659007018	Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010
335659007019	Cytochrome c; Region: Cytochrom_C; pfam00034
335659007020	Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641
335659007021	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761
335659007022	active site
335659007023	Coenzyme PQQ synthesis protein D (PqqD); Region: PqqD; cl05126
335659007024	Transcriptional regulators [Transcription]; Region: Lrp; COG1522
335659007025	AsnC family; Region: AsnC_trans_reg; pfam01037
335659007026	4-amino-5-hydroxymethyl-2-methyl-pyrimidine phosphate kinase (HMPP-kinase) catalyzes two consecutive phosphorylation steps in the thiamine phosphate biosynthesis pathway, leading to the synthesis of vitamin B1. The first step is the phosphorylation of...; Region: HMPP_kinase; cd01169
335659007027	dimer interface [polypeptide binding]; other site
335659007028	substrate binding site [chemical binding]; other site
335659007029	ATP binding site [chemical binding]; other site
335659007030	Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149
335659007031	Escherichia coli YbbF/LpxH and related proteins, metallophosphatase domain; Region: MPP_YbbF-LpxH; cd07398
335659007032	putative active site [active]
335659007033	putative metal binding site [ion binding]; other site
335659007034	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
335659007035	This family is most closely related to the GT1 family of glycosyltransferases. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can...; Region: GT1_like_2; cd03814
335659007036	Threonine dehydratase [Amino acid transport and metabolism]; Region: IlvA; COG1171
335659007037	Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562
335659007038	tetramer interface [polypeptide binding]; other site
335659007039	pyridoxal 5'-phosphate binding site [chemical binding]; other site
335659007040	catalytic residue [active]
335659007041	Uncharacterized protein containing caspase domain [General function prediction only]; Region: COG4249
335659007042	Caspase domain; Region: Peptidase_C14; pfam00656
335659007043	substrate pocket [chemical binding]; other site
335659007044	active site
335659007045	proteolytic cleavage site; other site
335659007046	dimer interface [polypeptide binding]; other site
335659007047	RbsD / FucU transport protein family; Region: RbsD_FucU; cl00809
335659007048	This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632
335659007049	active site
335659007050	metal binding site [ion binding]; metal-binding site
335659007051	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
335659007052	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
335659007053	putative 3-phenylpropionic acid transporter; Provisional; Region: PRK11128
335659007054	putative substrate translocation pore; other site
335659007055	L-Ala-D/L-Glu epimerase catalyzes the epimerization of L-Ala-D/L-Glu and other dipeptides. The genomic context and the substrate specificity of characterized members of this family from E.coli and B.subtilis indicates a possible role in the metabolism of...; Region: L-Ala-DL-Glu_epimerase; cd03319
335659007056	L-Ala-D/L-Glu epimerase; Provisional; Region: PRK15129
335659007057	active site
335659007058	ABC-type transport system involved in resistance to organic solvents, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2B; COG0767
335659007059	Permease; Region: Permease; pfam02405
335659007060	ABC-type transport system involved in resistance to organic solvents, ATPase component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2A; COG1127
335659007061	ATP-binding cassette transport system involved in resistant to organic solvents; Region: ABC_Org_Solvent_Resistant; cd03261
335659007062	Walker A/P-loop; other site
335659007063	ATP binding site [chemical binding]; other site
335659007064	Q-loop/lid; other site
335659007065	ABC transporter signature motif; other site
335659007066	Walker B; other site
335659007067	D-loop; other site
335659007068	H-loop/switch region; other site
335659007069	ABC-type transport system involved in resistance to organic solvents, periplasmic component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2C; COG1463
335659007070	mce related protein; Region: MCE; pfam02470
335659007071	Ferredoxin [Energy production and conversion]; Region: Fdx; COG0633
335659007072	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
335659007073	catalytic loop [active]
335659007074	iron binding site [ion binding]; other site
335659007075	4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586
335659007076	active site
335659007077	Thioredoxin reductase [Posttranslational modification, protein turnover, chaperones]; Region: TrxB; COG0492
335659007078	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
335659007079	Uncharacterized protein conserved in bacteria (DUF2147); Region: DUF2147; pfam09917
335659007080	galactarate dehydratase; Region: galactar-dH20; TIGR03248
335659007081	Domains similar to fish antifreeze type III protein; Region: SAF_AH_GD; cd11613
335659007082	D-galactarate dehydratase / Altronate hydrolase, C terminus; Region: GD_AH_C; pfam04295
335659007083	Bacillus subtilis NADP+-dependent alpha-ketoglutaric semialdehyde dehydrogenase ycbD-like; Region: ALDH_KGSADH-YcbD; cd07097
335659007084	Aldehyde dehydrogenase family; Region: Aldedh; pfam00171
335659007085	NAD(P) binding site [chemical binding]; other site
335659007086	catalytic residues [active]
335659007087	glucarate dehydratase; Region: glucar-dehydr; TIGR03247
335659007088	D-Glucarate dehydratase (GlucD) catalyzes the dehydration of both D-glucarate and L-idarate to form 5-keto-4-deoxy-D-glucarate (5-KDG) , the initial reaction of the catabolic pathway for (D)-glucarate. GlucD belongs to the enolase superfamily of enzymes; Region: D-glucarate_dehydratase; cd03323
335659007089	active site
335659007090	tetramer interface [polypeptide binding]; other site
335659007091	Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329
335659007092	5-dehydro-4-deoxyglucarate dehydratase, also called 5-keto-4-deoxy-glucarate dehydratase (KDGDH); Region: KDGDH; cd00951
335659007093	putative active site [active]
335659007094	catalytic residue [active]
335659007095	DNA-binding transcriptional regulator HcaR; Provisional; Region: PRK09906
335659007096	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
335659007097	The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator similar to regulators involved in the catabolism of aromatic compounds, contains type 2 periplasmic binding fold; Region: PBP2_LTTR_aromatics_like_1; cd08447
335659007098	putative dimerization interface [polypeptide binding]; other site
335659007099	putative substrate binding pocket [chemical binding]; other site
335659007100	SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cl01053
335659007101	active site
335659007102	oxyanion hole [active]
335659007103	catalytic triad [active]
335659007104	Predicted integral membrane protein [Function unknown]; Region: COG0392
335659007105	YciF bacterial stress response protein, ferritin-like iron-binding domain; Region: YciF; cd07909
335659007106	dimerization interface [polypeptide binding]; other site
335659007107	metal binding site [ion binding]; metal-binding site
335659007108	YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259
335659007109	putative active site [active]
335659007110	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167
335659007111	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
335659007112	DNA-binding site [nucleotide binding]; DNA binding site
335659007113	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
335659007114	pyridoxal 5'-phosphate binding site [chemical binding]; other site
335659007115	homodimer interface [polypeptide binding]; other site
335659007116	catalytic residue [active]
335659007117	Domain of unknown function (DUF1127); Region: DUF1127; pfam06568
335659007118	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
335659007119	Ligand Binding Site [chemical binding]; other site
335659007120	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
335659007121	catalytic core [active]
335659007122	putative aminophosphonate oxidoreductase; Region: Phn_aa_oxid; TIGR03329
335659007123	Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665
335659007124	methionine sulfoxide reductase B; Provisional; Region: PRK00222
335659007125	SelR domain; Region: SelR; pfam01641
335659007126	flagellar hook-basal body protein; Region: FlgEFG_subfam; TIGR03506
335659007127	Flagellar basal body protein FlaE; Region: FlaE; pfam07559
335659007128	Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429
335659007129	flagellar hook-associated protein FlgK; Region: flgK_ends; TIGR02492
335659007130	Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429
335659007131	Bacterial flagellin C-terminal helical region; Region: Flagellin_C; pfam00700
335659007132	ATP-grasp domain; Region: ATP-grasp_4; cl17255
335659007133	tyrosine decarboxylase; Region: PLN02880
335659007134	DOPA decarboxylase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to DOPA/tyrosine decarboxylase (DDC), histidine decarboxylase (HDC), and...; Region: DOPA_deC_like; cd06450
335659007135	pyridoxal 5'-phosphate binding site [chemical binding]; other site
335659007136	catalytic residue [active]
335659007137	flagellar biosynthesis repressor FlbT; Reviewed; Region: flbT; PRK12791
335659007138	flagellin; Reviewed; Region: PRK12688
335659007139	flagellin; Reviewed; Region: PRK12688
335659007140	Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669
335659007141	flagellar biosynthesis regulatory protein FlaF; Reviewed; Region: flaF; PRK12794
335659007142	chemotactic signal-response protein CheL; Provisional; Region: PRK12790
335659007143	flagellar basal body P-ring protein; Provisional; Region: flgI; PRK05303
335659007144	flagellar basal body P-ring protein; Reviewed; Region: flgI; cl14622
335659007145	flagellar assembly regulator FliX; Reviewed; Region: fliX; PRK12787
335659007146	Predicted transcriptional regulators [Transcription]; Region: COG1733
335659007147	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
335659007148	dimerization interface [polypeptide binding]; other site
335659007149	putative DNA binding site [nucleotide binding]; other site
335659007150	putative Zn2+ binding site [ion binding]; other site
335659007151	biliverdin IX beta reductase (BVR-B, aka flavin reductase)-like proteins; atypical (a) SDRs; Region: BVR-B_like_SDR_a; cd05244
335659007152	NADH(P)-binding; Region: NAD_binding_10; pfam13460
335659007153	NAD binding site [chemical binding]; other site
335659007154	putative active site [active]
335659007155	substrate binding site [chemical binding]; other site
335659007156	RNA polymerase-binding protein DksA; Region: dksA; TIGR02420
335659007157	Predicted transcriptional regulators [Transcription]; Region: COG1733
335659007158	HxlR-like helix-turn-helix; Region: HxlR; pfam01638
335659007159	hopanoid-associated sugar epimerase; Region: HpnA; TIGR03466
335659007160	aldehyde reductase, extended (e) SDRs; Region: AR_SDR_e; cd05227
335659007161	NADP binding site [chemical binding]; other site
335659007162	putative substrate binding site [chemical binding]; other site
335659007163	active site
335659007164	Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; cl11421
335659007165	flagellar basal body L-ring protein; Reviewed; Region: flgH; PRK00249
335659007166	Flagellar basal body L-ring protein [Cell motility and secretion]; Region: FlgH; COG2063
335659007167	flagellar basal body P-ring biosynthesis protein FlgA; Reviewed; Region: flgA; PRK12786
335659007168	SAF domains of the flagella basal body P-ring formation protein FlgA and the flp pilus assembly CpaB; Region: SAF_CpaB_FlgA_like; cd11614
335659007169	Domains similar to fish antifreeze type III protein; Region: SAF; cl00555
335659007170	flagellar basal body rod protein FlgG; Reviewed; Region: flgG; PRK12691
335659007171	Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460
335659007172	Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429
335659007173	flagellar basal body rod protein FlgF; Reviewed; Region: flgF; PRK12689
335659007174	flagellar basal-body rod protein FlgF; Region: flgF; TIGR02490
335659007175	flagellar basal body-associated protein FliL; Reviewed; Region: fliL; PRK12785
335659007176	flagellar motor switch protein FliM; Reviewed; Region: fliM; PRK12795
335659007177	Surface presentation of antigens (SPOA); Region: SpoA; pfam01052
335659007178	Uncharacterized conserved protein [Function unknown]; Region: COG3334
335659007179	flagellar biosynthesis protein FliP; Reviewed; Region: fliP; PRK05699
335659007180	Flagellar biosynthesis protein, FliO; Region: FliO; cl01247
335659007181	flagellar basal body rod protein FlgB; Reviewed; Region: flgB; PRK06004
335659007182	flagellar basal body rod protein FlgC; Reviewed; Region: flgC; PRK05681
335659007183	Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429
335659007184	Flagellar hook-basal body complex protein FliE; Region: FliE; cl09139
335659007185	flagellar biosynthesis protein FliQ; Reviewed; Region: fliQ; PRK06010
335659007186	flagellar biosynthesis protein FliR; Reviewed; Region: fliR; PRK05701
335659007187	flagellar biosynthesis protein FlhB; Reviewed; Region: flhB; PRK05702
335659007188	Uncharacterized homolog of the cytoplasmic domain of flagellar protein FhlB [Function unknown]; Region: COG2257
335659007189	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
335659007190	PAS domain; Region: PAS_9; pfam13426
335659007191	putative active site [active]
335659007192	heme pocket [chemical binding]; other site
335659007193	Signal transduction histidine kinase, nitrogen specific [Signal transduction mechanisms]; Region: NtrB; COG3852
335659007194	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
335659007195	dimer interface [polypeptide binding]; other site
335659007196	phosphorylation site [posttranslational modification]
335659007197	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
335659007198	ATP binding site [chemical binding]; other site
335659007199	Mg2+ binding site [ion binding]; other site
335659007200	G-X-G motif; other site
335659007201	Response regulator receiver domain; Region: Response_reg; pfam00072
335659007202	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
335659007203	active site
335659007204	phosphorylation site [posttranslational modification]
335659007205	intermolecular recognition site; other site
335659007206	dimerization interface [polypeptide binding]; other site
335659007207	Tim44-like domain; Region: Tim44; pfam04280
335659007208	GST_N family, Class Sigma_like; composed of GSTs belonging to class Sigma and similar proteins, including GSTs from class Mu, Pi and Alpha. GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of...; Region: GST_N_Sigma_like; cd03039
335659007209	glutathione s-transferase; Provisional; Region: PTZ00057
335659007210	GSH binding site (G-site) [chemical binding]; other site
335659007211	C-terminal domain interface [polypeptide binding]; other site
335659007212	dimer interface [polypeptide binding]; other site
335659007213	C-terminal, alpha helical domain of Class Sigma-like Glutathione S-transferases; Region: GST_C_Sigma_like; cd03192
335659007214	dimer interface [polypeptide binding]; other site
335659007215	N-terminal domain interface [polypeptide binding]; other site
335659007216	substrate binding pocket (H-site) [chemical binding]; other site
335659007217	fumarate hydratase; Provisional; Region: PRK15389
335659007218	Fumarate hydratase (Fumerase); Region: Fumerase; pfam05681
335659007219	Fumarase C-terminus; Region: Fumerase_C; pfam05683
335659007220	Bacterial SH3 domain; Region: SH3_3; cl17532
335659007221	Intracellular septation protein A; Region: IspA; cl01098
335659007222	Lignostilbene-alpha,beta-dioxygenase and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3670
335659007223	Retinal pigment epithelial membrane protein; Region: RPE65; pfam03055
335659007224	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
335659007225	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
335659007226	WHG domain; Region: WHG; pfam13305
335659007227	SET (Su(var)3-9, Enhancer-of-zeste, Trithorax) domain; Region: SET; smart00317
335659007228	Response regulator receiver domain; Region: Response_reg; pfam00072
335659007229	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
335659007230	active site
335659007231	phosphorylation site [posttranslational modification]
335659007232	intermolecular recognition site; other site
335659007233	dimerization interface [polypeptide binding]; other site
335659007234	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
335659007235	dimer interface [polypeptide binding]; other site
335659007236	phosphorylation site [posttranslational modification]
335659007237	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
335659007238	ATP binding site [chemical binding]; other site
335659007239	Mg2+ binding site [ion binding]; other site
335659007240	G-X-G motif; other site
335659007241	Response regulator receiver domain; Region: Response_reg; pfam00072
335659007242	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
335659007243	active site
335659007244	phosphorylation site [posttranslational modification]
335659007245	intermolecular recognition site; other site
335659007246	dimerization interface [polypeptide binding]; other site
335659007247	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
335659007248	ATP binding site [chemical binding]; other site
335659007249	Mg2+ binding site [ion binding]; other site
335659007250	G-X-G motif; other site
335659007251	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
335659007252	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
335659007253	dimer interface [polypeptide binding]; other site
335659007254	phosphorylation site [posttranslational modification]
335659007255	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
335659007256	ATP binding site [chemical binding]; other site
335659007257	Mg2+ binding site [ion binding]; other site
335659007258	G-X-G motif; other site
335659007259	FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784
335659007260	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
335659007261	active site
335659007262	phosphorylation site [posttranslational modification]
335659007263	intermolecular recognition site; other site
335659007264	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075
335659007265	Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228
335659007266	Anti-sigma regulatory factor (Ser/Thr protein kinase) [Signal transduction mechanisms]; Region: RsbW; COG2172
335659007267	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075
335659007268	Sulphate Transporter and Anti-Sigma factor antagonist domain of the "stressosome" complex proteins RsbS and RsbR, regulators of the bacterial stress activated alternative sigma factor sigma-B by phosphorylation; Region: STAS_RsbR_RsbS_like; cd07041
335659007269	RsbT co-antagonist protein rsbRD N-terminal domain; Region: RsbRD_N; pfam14361
335659007270	Sulphate Transporter and Anti-Sigma factor antagonist domain of the "stressosome" complex proteins RsbS and RsbR, regulators of the bacterial stress activated alternative sigma factor sigma-B by phosphorylation; Region: STAS_RsbR_RsbS_like; cd07041
335659007271	Intradiol dioxygenases catalyze the critical ring-cleavage step in the conversion of catecholate derivatives to citric acid cycle intermediates. This family contains catechol 1,2-dioxygenases and protocatechuate 3,4-dioxygenases which are mononuclear...; Region: intradiol_dioxygenase; cl17208
335659007272	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
335659007273	non-specific DNA binding site [nucleotide binding]; other site
335659007274	salt bridge; other site
335659007275	sequence-specific DNA binding site [nucleotide binding]; other site
335659007276	Predicted dithiol-disulfide isomerase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: FrnE; COG2761
335659007277	DsbA family, FrnE subfamily; FrnE is a DsbA-like protein containing a CXXC motif. It is presumed to be a thiol oxidoreductase involved in polyketide biosynthesis, specifically in the production of the aromatic antibiotics frenolicin and nanaomycins; Region: DsbA_FrnE; cd03024
335659007278	catalytic residues [active]
335659007279	Acetyltransferase (GNAT) domain; Region: Acetyltransf_6; pfam13480
335659007280	cytochrome c oxidase accessory protein FixG; Region: ccoG_rdxA_fixG; TIGR02745
335659007281	4Fe-4S binding domain; Region: Fer4_5; pfam12801
335659007282	Ubp3 associated protein Bre5; Region: Bre5; pfam11614
335659007283	Domain of unknown function DUF302; Region: DUF302; pfam03625
335659007284	Protein of unknown function (DUF2892); Region: DUF2892; pfam11127
335659007285	TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947
335659007286	Thioredoxin-like; Region: Thioredoxin_8; pfam13905
335659007287	catalytic residues [active]
335659007288	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_2; pfam07992
335659007289	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
335659007290	dimerization interface [polypeptide binding]; other site
335659007291	putative DNA binding site [nucleotide binding]; other site
335659007292	putative Zn2+ binding site [ion binding]; other site
335659007293	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
335659007294	Membrane Fusion Protein cluster 2 (function with RND porters); Region: 8a0102; TIGR00999
335659007295	HlyD family secretion protein; Region: HlyD_3; pfam13437
335659007296	Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841
335659007297	Uncharacterized homolog of gamma-carboxymuconolactone decarboxylase subunit [Function unknown]; Region: COG0599
335659007298	Membrane-bound PQQ-dependent glucose dehydrogenase; Region: PQQ_mGDH; cd10280
335659007299	PQQ-dependent dehydrogenase, methanol/ethanol family; Region: PQQ_enz_alc_DH; TIGR03075
335659007300	Trp docking motif [polypeptide binding]; other site
335659007301	putative active site [active]
335659007302	PilZ domain; Region: PilZ; pfam07238
335659007303	HdeA/HdeB family; Region: HdeA; cl05752
335659007304	PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria.  Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443
335659007305	CoenzymeA binding site [chemical binding]; other site
335659007306	subunit interaction site [polypeptide binding]; other site
335659007307	PHB binding site; other site
335659007308	Protein of unknown function (DUF2798); Region: DUF2798; pfam11391
335659007309	recombinase A; Provisional; Region: recA; PRK09354
335659007310	RecA is a  bacterial enzyme which has roles in homologous recombination, DNA repair, and the induction of the SOS response.  RecA couples ATP hydrolysis to DNA strand exchange; Region: recA; cd00983
335659007311	hexamer interface [polypeptide binding]; other site
335659007312	Walker A motif; other site
335659007313	ATP binding site [chemical binding]; other site
335659007314	Walker B motif; other site
335659007315	glycine dehydrogenase; Provisional; Region: PRK05367
335659007316	Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613
335659007317	tetramer interface [polypeptide binding]; other site
335659007318	pyridoxal 5'-phosphate binding site [chemical binding]; other site
335659007319	catalytic residue [active]
335659007320	Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613
335659007321	tetramer interface [polypeptide binding]; other site
335659007322	pyridoxal 5'-phosphate binding site [chemical binding]; other site
335659007323	catalytic residue [active]
335659007324	Glycine cleavage H-protein. Glycine cleavage H-proteins are part of the glycine cleavage system (GCS) found in bacteria, archea and the mitochondria of eukaryotes. GCS is a multienzyme complex consisting of 4 different components (P-, H-, T- and...; Region: GCS_H; cd06848
335659007325	lipoyl attachment site [posttranslational modification]; other site
335659007326	glycine cleavage system aminomethyltransferase T; Provisional; Region: gcvT; PRK13579
335659007327	Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669
335659007328	glycine riboswitch as predicted by Rfam v8.1 (RF00504), score 33.96
335659007329	glycine riboswitch as predicted by Rfam v8.1 (RF00504), score 62.24
335659007330	alanyl-tRNA synthetase; Reviewed; Region: alaS; PRK00252
335659007331	Alanyl-tRNA synthetase (AlaRS) class II core catalytic domain. AlaRS is a homodimer. It is responsible for the attachment of alanine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: AlaRS_core; cd00673
335659007332	motif 1; other site
335659007333	active site
335659007334	motif 2; other site
335659007335	motif 3; other site
335659007336	Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863
335659007337	Ion transport protein; Region: Ion_trans; pfam00520
335659007338	Ion channel; Region: Ion_trans_2; pfam07885
335659007339	cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664
335659007340	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
335659007341	ligand binding site [chemical binding]; other site
335659007342	flexible hinge region; other site
335659007343	Protein of unknown function (DUF3303); Region: DUF3303; pfam11746
335659007344	Protein of unknown function (DUF3455); Region: DUF3455; pfam11937
335659007345	isocitrate dehydrogenase; Validated; Region: PRK08299
335659007346	rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: LasT; COG0565
335659007347	SpoU rRNA Methylase family; Region: SpoU_methylase; cl17307
335659007348	Domain of unknown function, appears to be related to a diverse group of endonucleases; Region: Endonuclease_DUF559; cd01038
335659007349	putative active site [active]
335659007350	SnoaL-like domain; Region: SnoaL_2; pfam12680
335659007351	short chain dehydrogenase; Provisional; Region: PRK06500
335659007352	classical (c) SDRs; Region: SDR_c; cd05233
335659007353	NAD(P) binding site [chemical binding]; other site
335659007354	active site
335659007355	LysR family transcriptional regulator; Provisional; Region: PRK14997
335659007356	The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_4; cd08473
335659007357	putative effector binding pocket; other site
335659007358	putative dimerization interface [polypeptide binding]; other site
335659007359	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
335659007360	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
335659007361	metal binding site [ion binding]; metal-binding site
335659007362	active site
335659007363	I-site; other site
335659007364	The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cd03440
335659007365	active site 2 [active]
335659007366	NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604
335659007367	Quinone oxidoreductase (QOR); Region: QOR1; cd08241
335659007368	NAD(P) binding site [chemical binding]; other site
335659007369	Putative protein-S-isoprenylcysteine methyltransferase [Posttranslational modification, protein turnover, chaperones]; Region: STE14; COG2020
335659007370	Bacterial transcriptional activator domain; Region: BTAD; smart01043
335659007371	Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596
335659007372	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
335659007373	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
335659007374	OsmC-like protein; Region: OsmC; pfam02566
335659007375	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
335659007376	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
335659007377	active site
335659007378	Rhodanese-related sulfurtransferase [Inorganic ion transport and metabolism]; Region: SseA; COG2897
335659007379	Rhodanese-like domain; Region: Rhodanese; pfam00581
335659007380	active site residue [active]
335659007381	Thiosulfate sulfurtransferase (TST), C-terminal, catalytic domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the second repeat. Only the second repeat contains the catalytically active Cys residue; Region: TST_Repeat_2; cd01449
335659007382	active site residue [active]
335659007383	PAS domain; Region: PAS_8; pfam13188
335659007384	PAS domain; Region: PAS_9; pfam13426
335659007385	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
335659007386	putative active site [active]
335659007387	heme pocket [chemical binding]; other site
335659007388	PAS domain S-box; Region: sensory_box; TIGR00229
335659007389	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
335659007390	putative active site [active]
335659007391	heme pocket [chemical binding]; other site
335659007392	psp operon transcriptional activator PspF; Region: phageshock_pspF; TIGR02974
335659007393	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
335659007394	Walker A motif; other site
335659007395	ATP binding site [chemical binding]; other site
335659007396	Walker B motif; other site
335659007397	arginine finger; other site
335659007398	ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components [Inorganic ion transport and metabolism]; Region: TauA; COG0715
335659007399	NMT1-like family; Region: NMT1_2; pfam13379
335659007400	ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600
335659007401	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
335659007402	dimer interface [polypeptide binding]; other site
335659007403	conserved gate region; other site
335659007404	putative PBP binding loops; other site
335659007405	ABC-ATPase subunit interface; other site
335659007406	ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116
335659007407	ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293
335659007408	Walker A/P-loop; other site
335659007409	ATP binding site [chemical binding]; other site
335659007410	Q-loop/lid; other site
335659007411	ABC transporter signature motif; other site
335659007412	Walker B; other site
335659007413	D-loop; other site
335659007414	H-loop/switch region; other site
335659007415	cyanate hydratase; Validated; Region: PRK02866
335659007416	Cyanase C-terminal domain. Cyanase (Cyanate lyase) is responsible for the hydrolysis of cyanate.  It catalyzes the reaction of cyanate with bicarbonate to produce ammonia and carbon dioxide. This allows organisms that possess the enzyme to overcome the...; Region: Cyanase_C; cd00559
335659007417	oligomer interface [polypeptide binding]; other site
335659007418	active site
335659007419	Domain of unknown function (DUF1476); Region: DUF1476; pfam07345
335659007420	phosphoribosylaminoimidazole-succinocarboxamide synthase; Reviewed; Region: PRK09362
335659007421	bacterial and archaeal 5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide (SAICAR) synthase; Region: SAICAR_synt_PurC; cd01415
335659007422	ATP binding site [chemical binding]; other site
335659007423	active site
335659007424	substrate binding site [chemical binding]; other site
335659007425	phosphoribosylformylglycinamidine synthase subunit PurS; Reviewed; Region: PRK05974
335659007426	phosphoribosylformylglycinamidine synthase I; Provisional; Region: PRK03619
335659007427	Type 1 glutamine amidotransferase (GATase1)-like domain found in Formylglycinamide ribonucleotide amidotransferase; Region: GATase1_FGAR_AT; cd01740
335659007428	putative active site [active]
335659007429	catalytic triad [active]
335659007430	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3181
335659007431	Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697
335659007432	EamA-like transporter family; Region: EamA; pfam00892
335659007433	PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria.  Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443
335659007434	CoenzymeA binding site [chemical binding]; other site
335659007435	subunit interaction site [polypeptide binding]; other site
335659007436	PHB binding site; other site
335659007437	phosphoribosylformylglycinamidine synthase II; Provisional; Region: PRK01213
335659007438	PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), first repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat1; cd02203
335659007439	dimerization interface [polypeptide binding]; other site
335659007440	ATP binding site [chemical binding]; other site
335659007441	PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), second repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat2; cd02204
335659007442	dimerization interface [polypeptide binding]; other site
335659007443	ATP binding site [chemical binding]; other site
335659007444	Acyltransferase family; Region: Acyl_transf_3; pfam01757
335659007445	glucans biosynthesis protein; Provisional; Region: opgC; PRK03854
335659007446	Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596
335659007447	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2343
335659007448	Stress-induced morphogen (activity unknown) [Signal transduction mechanisms]; Region: BolA; COG0271
335659007449	Bacterial low temperature requirement A protein (LtrA); Region: LtrA; pfam06772
335659007450	dimethylhistidine N-methyltransferase; Region: egtD_ergothio; TIGR03438
335659007451	Uncharacterized conserved protein (DUF2260); Region: DUF2260; pfam10017
335659007452	ergothioneine biosynthesis protein EgtB; Region: egtB_TIGR03440
335659007453	Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; pfam03781
335659007454	Glutaredoxin (GRX) family, PKC-interacting cousin of TRX (PICOT)-like subfamily; composed of PICOT and GRX-PICOT-like proteins. The non-PICOT members of this family contain only the GRX-like domain, whereas PICOT contains an N-terminal TRX-like domain...; Region: GRX_PICOT_like; cd03028
335659007455	putative GSH binding site [chemical binding]; other site
335659007456	catalytic residues [active]
335659007457	Macro domain, Appr-1"-pase_like family. The macro domain is a high-affinity ADP-ribose binding module found in a variety of proteins as a stand-alone domain or in combination with other domains like in histone macroH2A and some PARPs (poly...; Region: Macro_Appr_pase_like; cd02908
335659007458	putative ADP-ribose binding site [chemical binding]; other site
335659007459	putative active site [active]
335659007460	Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680
335659007461	Beta-lactamase; Region: Beta-lactamase; pfam00144
335659007462	Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680
335659007463	Beta-lactamase; Region: Beta-lactamase; pfam00144
335659007464	Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321
335659007465	Beta-eliminating lyase; Region: Beta_elim_lyase; pfam01212
335659007466	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
335659007467	catalytic residue [active]
335659007468	30S ribosomal protein S4; Validated; Region: rpsD; PRK05327
335659007469	Ribosomal protein S4/S9 N-terminal domain; Region: Ribosomal_S4; pfam00163
335659007470	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
335659007471	RNA binding surface [nucleotide binding]; other site
335659007472	Cupin domain; Region: Cupin_2; pfam07883
335659007473	HpcH/HpaI aldolase/citrate lyase family; Region: HpcH_HpaI; cl17231
335659007474	glutamate racemase; Provisional; Region: PRK00865
335659007475	Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625
335659007476	GST_N family, Saccharomyces cerevisiae GTT1-like subfamily; composed of predominantly uncharacterized proteins with similarity to the S. cerevisiae GST protein, GTT1, and the Schizosaccharomyces pombe GST-III. GSTs are cytosolic dimeric proteins involved...; Region: GST_N_GTT1_like; cd03046
335659007477	putative C-terminal domain interface [polypeptide binding]; other site
335659007478	putative GSH binding site (G-site) [chemical binding]; other site
335659007479	putative dimer interface [polypeptide binding]; other site
335659007480	C-terminal, alpha helical domain of the Glutathione S-transferase family; Region: GST_C_family; cl02776
335659007481	N-terminal domain interface [polypeptide binding]; other site
335659007482	dimer interface [polypeptide binding]; other site
335659007483	substrate binding pocket (H-site) [chemical binding]; other site
335659007484	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
335659007485	cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664
335659007486	ligand binding site [chemical binding]; other site
335659007487	flexible hinge region; other site
335659007488	bifunctional preprotein translocase subunit SecD/SecF; Provisional; Region: PRK14726
335659007489	ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410
335659007490	ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224
335659007491	Walker A/P-loop; other site
335659007492	ATP binding site [chemical binding]; other site
335659007493	Q-loop/lid; other site
335659007494	ABC transporter signature motif; other site
335659007495	Walker B; other site
335659007496	D-loop; other site
335659007497	H-loop/switch region; other site
335659007498	ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411
335659007499	ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219
335659007500	Walker A/P-loop; other site
335659007501	ATP binding site [chemical binding]; other site
335659007502	Q-loop/lid; other site
335659007503	ABC transporter signature motif; other site
335659007504	Walker B; other site
335659007505	D-loop; other site
335659007506	H-loop/switch region; other site
335659007507	ABC-type branched-chain amino acid transport system, permease component [Amino acid transport and metabolism]; Region: LivM; COG4177
335659007508	Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581
335659007509	TM-ABC transporter signature motif; other site
335659007510	Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582
335659007511	TM-ABC transporter signature motif; other site
335659007512	Periplasmic binding protein; Region: Peripla_BP_6; pfam13458
335659007513	Type I periplasmic ligand-binding domain of uncharacterized ABC (ATPase Binding Cassette)-type active transport systems that are predicted to be involved in transport of amino acids, peptides, or inorganic ions; Region: PBP1_ABC_ligand_binding_like_5; cd06338
335659007514	putative ligand binding site [chemical binding]; other site
335659007515	Transcriptional regulator [Transcription]; Region: LysR; COG0583
335659007516	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
335659007517	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
335659007518	dimerization interface [polypeptide binding]; other site
335659007519	AMP-binding domain protein; Validated; Region: PRK07529
335659007520	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
335659007521	Uncharacterized subfamily of fatty acid CoA ligase (FACL); Region: FACL_like_4; cd05944
335659007522	acyl-activating enzyme (AAE) consensus motif; other site
335659007523	acyl-activating enzyme (AAE) consensus motif; other site
335659007524	putative AMP binding site [chemical binding]; other site
335659007525	putative active site [active]
335659007526	putative CoA binding site [chemical binding]; other site
335659007527	Caspase domain; Region: Peptidase_C14; pfam00656
335659007528	active site
335659007529	PAS fold; Region: PAS_7; pfam12860
335659007530	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
335659007531	PAS domain; Region: PAS_9; pfam13426
335659007532	putative active site [active]
335659007533	heme pocket [chemical binding]; other site
335659007534	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
335659007535	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
335659007536	metal binding site [ion binding]; metal-binding site
335659007537	active site
335659007538	I-site; other site
335659007539	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
335659007540	cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664
335659007541	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
335659007542	ligand binding site [chemical binding]; other site
335659007543	flexible hinge region; other site
335659007544	helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092
335659007545	putative switch regulator; other site
335659007546	non-specific DNA interactions [nucleotide binding]; other site
335659007547	DNA binding site [nucleotide binding]
335659007548	sequence specific DNA binding site [nucleotide binding]; other site
335659007549	putative cAMP binding site [chemical binding]; other site
335659007550	Globin domain present in Globin-Coupled-Sensors (GCS). These domains detect changes in intracellular concentrations of oxygen, carbon monoxyde, or nitrous oxide,  which result in aerotaxis and/or gene regulation. One subgroup, the HemATs, are aerotactic...; Region: sensor_globin; cd01068
335659007551	heme-binding site [chemical binding]; other site
335659007552	Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283
335659007553	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
335659007554	dimer interface [polypeptide binding]; other site
335659007555	putative CheW interface [polypeptide binding]; other site
335659007556	Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473
335659007557	M20 Peptidase Aminoacylase 1 subfamily; Region: M20_Acy1_like1; cd05666
335659007558	metal binding site [ion binding]; metal-binding site
335659007559	putative dimer interface [polypeptide binding]; other site
335659007560	adenylosuccinate lyase; Provisional; Region: PRK07492
335659007561	Adenylsuccinate lyase (ASL)_subgroup 1; Region: Adenylsuccinate_lyase_1; cd01360
335659007562	tetramer interface [polypeptide binding]; other site
335659007563	active site
335659007564	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
335659007565	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
335659007566	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
335659007567	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
335659007568	active site
335659007569	phosphorylation site [posttranslational modification]
335659007570	intermolecular recognition site; other site
335659007571	dimerization interface [polypeptide binding]; other site
335659007572	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
335659007573	DNA binding residues [nucleotide binding]
335659007574	dimerization interface [polypeptide binding]; other site
335659007575	Histidine kinase; Region: HisKA_3; pfam07730
335659007576	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
335659007577	ATP binding site [chemical binding]; other site
335659007578	Mg2+ binding site [ion binding]; other site
335659007579	G-X-G motif; other site
335659007580	Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149
335659007581	metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cd00838
335659007582	active site
335659007583	metal binding site [ion binding]; metal-binding site
335659007584	Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876
335659007585	Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220
335659007586	Catalytic domain of Protein Kinases; Region: PKc; cd00180
335659007587	active site
335659007588	ATP binding site [chemical binding]; other site
335659007589	substrate binding site [chemical binding]; other site
335659007590	activation loop (A-loop); other site
335659007591	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
335659007592	Ligand Binding Site [chemical binding]; other site
335659007593	Pentose-5-phosphate-3-epimerase [Carbohydrate transport and metabolism]; Region: Rpe; COG0036
335659007594	Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose...; Region: RPE; cd00429
335659007595	substrate binding site [chemical binding]; other site
335659007596	hexamer interface [polypeptide binding]; other site
335659007597	metal binding site [ion binding]; metal-binding site
335659007598	EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to...; Region: EFh; cd00051
335659007599	EF-hand domain pair; Region: EF_hand_5; pfam13499
335659007600	Ca2+ binding site [ion binding]; other site
335659007601	nylC-like family; composed of proteins with similarity to Flavobacterium endo-type 6-aminohexanoate-oligomer hydrolase (EIII), the product of the nylon oligomer degradation gene, nylC. EIII is an amide hydrolase that catalyzes the degradation of...; Region: nylC_like; cd02252
335659007602	putative active site pocket [active]
335659007603	cleavage site
335659007604	PAS domain S-box; Region: sensory_box; TIGR00229
335659007605	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
335659007606	putative active site [active]
335659007607	heme pocket [chemical binding]; other site
335659007608	PAS domain S-box; Region: sensory_box; TIGR00229
335659007609	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
335659007610	putative active site [active]
335659007611	heme pocket [chemical binding]; other site
335659007612	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
335659007613	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
335659007614	dimer interface [polypeptide binding]; other site
335659007615	phosphorylation site [posttranslational modification]
335659007616	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
335659007617	ATP binding site [chemical binding]; other site
335659007618	Mg2+ binding site [ion binding]; other site
335659007619	G-X-G motif; other site
335659007620	FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784
335659007621	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
335659007622	active site
335659007623	phosphorylation site [posttranslational modification]
335659007624	intermolecular recognition site; other site
335659007625	dimerization interface [polypeptide binding]; other site
335659007626	Response regulator receiver domain; Region: Response_reg; pfam00072
335659007627	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
335659007628	active site
335659007629	phosphorylation site [posttranslational modification]
335659007630	intermolecular recognition site; other site
335659007631	dimerization interface [polypeptide binding]; other site
335659007632	ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683
335659007633	Type I periplasmic ligand-binding domain of ABC (Atpase Binding Cassette)-type active transport systems that are involved in the transport of all three branched chain aliphatic amino acids (leucine, isoleucine and valine); Region: PBP1_ABC_LIVBP_like; cd06342
335659007634	dimerization interface [polypeptide binding]; other site
335659007635	ligand binding site [chemical binding]; other site
335659007636	ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410
335659007637	ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224
335659007638	Walker A/P-loop; other site
335659007639	ATP binding site [chemical binding]; other site
335659007640	Q-loop/lid; other site
335659007641	ABC transporter signature motif; other site
335659007642	Walker B; other site
335659007643	D-loop; other site
335659007644	H-loop/switch region; other site
335659007645	leucine/isoleucine/valine transporter ATP-binding subunit; Provisional; Region: livG; PRK11300
335659007646	ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219
335659007647	Walker A/P-loop; other site
335659007648	ATP binding site [chemical binding]; other site
335659007649	Q-loop/lid; other site
335659007650	ABC transporter signature motif; other site
335659007651	Walker B; other site
335659007652	D-loop; other site
335659007653	H-loop/switch region; other site
335659007654	Domain of unknown function (DUF3382); Region: DUF3382; pfam11862
335659007655	leucine/isoleucine/valine transporter permease subunit; Provisional; Region: livM; PRK11301
335659007656	Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581
335659007657	TM-ABC transporter signature motif; other site
335659007658	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
335659007659	Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582
335659007660	TM-ABC transporter signature motif; other site
335659007661	Carboxymuconolactone decarboxylase family; Region: CMD; cl00460
335659007662	3-oxoadipate enol-lactonase; Region: protocat_pcaD; TIGR02427
335659007663	3-carboxy-cis,cis-muconate cycloisomerase; Provisional; Region: PRK09053
335659007664	prokaryotic 3-carboxy-cis,cis-muconate cycloisomerase (CMLE)_like; Region: pCLME; cd01597
335659007665	tetramer interface [polypeptide binding]; other site
335659007666	active site
335659007667	Carbon monoxide dehydrogenase subunit G (CoxG); Region: CoxG; cd05018
335659007668	putative hydrophobic ligand binding site [chemical binding]; other site
335659007669	Aerobic-type carbon monoxide dehydrogenase, small subunit CoxS/CutS homologs [Energy production and conversion]; Region: CoxS; COG2080
335659007670	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
335659007671	catalytic loop [active]
335659007672	iron binding site [ion binding]; other site
335659007673	[2Fe-2S] binding domain; Region: Fer2_2; pfam01799
335659007674	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM/CutM homologs [Energy production and conversion]; Region: CoxM; COG1319
335659007675	CO dehydrogenase flavoprotein C-terminal domain; Region: CO_deh_flav_C; smart01092
335659007676	MoxR-like ATPases [General function prediction only]; Region: COG0714
335659007677	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
335659007678	Walker A motif; other site
335659007679	ATP binding site [chemical binding]; other site
335659007680	Walker B motif; other site
335659007681	arginine finger; other site
335659007682	Protein containing von Willebrand factor type A (vWA) domain [General function prediction only]; Region: CoxE; COG3552
335659007683	Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198
335659007684	metal ion-dependent adhesion site (MIDAS); other site
335659007685	XdhC and CoxI family; Region: XdhC_CoxI; pfam02625
335659007686	Xanthine and CO dehydrogenases maturation factor, XdhC/CoxF family [Posttranslational modification, protein turnover, chaperones]; Region: XdhC; COG1975
335659007687	XdhC Rossmann domain; Region: XdhC_C; pfam13478
335659007688	MoeA_like. This domain is similar to a domain found in a variety of proteins involved in biosynthesis of molybdopterin cofactor, like MoaB, MogA, and MoeA. There this domain is presumed to bind molybdopterin. The exact function of this subgroup is...; Region: MoeA_like; cd03522
335659007689	putative MPT binding site; other site
335659007690	GT_2_like_f is a subfamily of the glycosyltransferase family 2 (GT-2) with unknown function; Region: GT_2_like_f; cd04182
335659007691	molybdopterin-guanine dinucleotide biosynthesis protein MobA; Reviewed; Region: mobA; PRK00317
335659007692	Ligand binding site; other site
335659007693	metal-binding site
335659007694	Domain of unknown function (DUF4189); Region: DUF4189; pfam13827
335659007695	Protein of unknown function (DUF2000); Region: DUF2000; pfam09391
335659007696	Zn-dependent alcohol dehydrogenases [General function prediction only]; Region: AdhP; COG1064
335659007697	Cinnamyl alcohol dehydrogenases (CAD); Region: CAD3; cd08297
335659007698	NAD binding site [chemical binding]; other site
335659007699	substrate binding site [chemical binding]; other site
335659007700	catalytic Zn binding site [ion binding]; other site
335659007701	tetramer interface [polypeptide binding]; other site
335659007702	structural Zn binding site [ion binding]; other site
335659007703	NAD-dependent, lactate dehydrogenase-like, 2-hydroxycarboxylate dehydrogenase family; Region: LDH_MDH_like; cl17195
335659007704	alpha-galactosidase; Provisional; Region: PRK15076
335659007705	NAD(P) binding site [chemical binding]; other site
335659007706	LDH/MDH dimer interface [polypeptide binding]; other site
335659007707	substrate binding site [chemical binding]; other site
335659007708	Glutathione-dependent formaldehyde-activating enzyme; Region: GFA; pfam04828
335659007709	Putative hydrophobic ligand-binding SRPBCC domain of Micromonospora echinospora CalC, human Aha1, and related proteins; Region: SRPBCC_CalC_Aha1-like; cd07814
335659007710	putative hydrophobic ligand binding site [chemical binding]; other site
335659007711	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
335659007712	putative DNA binding site [nucleotide binding]; other site
335659007713	dimerization interface [polypeptide binding]; other site
335659007714	putative Zn2+ binding site [ion binding]; other site
335659007715	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
335659007716	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
335659007717	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
335659007718	HlyD family secretion protein; Region: HlyD_3; pfam13437
335659007719	ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131
335659007720	ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230
335659007721	Walker A/P-loop; other site
335659007722	ATP binding site [chemical binding]; other site
335659007723	Q-loop/lid; other site
335659007724	ABC transporter signature motif; other site
335659007725	Walker B; other site
335659007726	D-loop; other site
335659007727	H-loop/switch region; other site
335659007728	ABC-type Na+ efflux pump, permease component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatB; COG1668
335659007729	ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842
335659007730	ABC-2 type transporter; Region: ABC2_membrane; pfam01061
335659007731	Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114
335659007732	cyclase homology domain; Region: CHD; cd07302
335659007733	nucleotidyl binding site; other site
335659007734	metal binding site [ion binding]; metal-binding site
335659007735	dimer interface [polypeptide binding]; other site
335659007736	Predicted epimerase, PhzC/PhzF homolog [General function prediction only]; Region: COG0384
335659007737	Protein of unknown function, DUF488; Region: DUF488; pfam04343
335659007738	Protein of unknown function DUF72; Region: DUF72; pfam01904
335659007739	dolichyl-phosphate beta-D-mannosyltransferase; Region: PLN02726
335659007740	DPM1_like represents putative enzymes similar to eukaryotic DPM1; Region: DPM1_like; cd06442
335659007741	Ligand binding site; other site
335659007742	Putative Catalytic site; other site
335659007743	DXD motif; other site
335659007744	Predicted membrane protein [Function unknown]; Region: COG2246
335659007745	GtrA-like protein; Region: GtrA; pfam04138
335659007746	Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; pfam13231
335659007747	CHASE2 is an extracellular sensory domain, which is present in various classes of transmembrane receptors that are parts of signal transduction pathways in bacteria; Region: CHASE2; smart01080
335659007748	Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114
335659007749	cyclase homology domain; Region: CHD; cd07302
335659007750	nucleotidyl binding site; other site
335659007751	metal binding site [ion binding]; metal-binding site
335659007752	dimer interface [polypeptide binding]; other site
335659007753	FecR protein; Region: FecR; pfam04773
335659007754	Protein of unknown function (DUF2778); Region: DUF2778; pfam10908
335659007755	3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557
335659007756	classical (c) SDRs; Region: SDR_c; cd05233
335659007757	NAD(P) binding site [chemical binding]; other site
335659007758	active site
335659007759	Caspase domain; Region: Peptidase_C14; pfam00656
335659007760	glutathionine S-transferase; Provisional; Region: PRK10542
335659007761	GST_N family, Class Beta subfamily; GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of endogenous and xenobiotic alkylating agents, including carcinogens; Region: GST_N_Beta; cd03057
335659007762	C-terminal domain interface [polypeptide binding]; other site
335659007763	GSH binding site (G-site) [chemical binding]; other site
335659007764	dimer interface [polypeptide binding]; other site
335659007765	C-terminal, alpha helical domain of Class Beta Glutathione S-transferases; Region: GST_C_Beta; cd03188
335659007766	dimer interface [polypeptide binding]; other site
335659007767	N-terminal domain interface [polypeptide binding]; other site
335659007768	substrate binding pocket (H-site) [chemical binding]; other site
335659007769	Isochorismatase family; Region: Isochorismatase; pfam00857
335659007770	Nicotinamidase_ related amidohydrolases.  Cysteine hydrolases of unknown function that share the catalytic triad with other amidohydrolases, like nicotinamidase, which converts nicotinamide to nicotinic acid and ammonia; Region: nicotinamidase_related; cd01014
335659007771	catalytic triad [active]
335659007772	conserved cis-peptide bond; other site
335659007773	Transcriptional regulator [Transcription]; Region: LysR; COG0583
335659007774	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
335659007775	LysR substrate binding domain; Region: LysR_substrate; pfam03466
335659007776	dimerization interface [polypeptide binding]; other site
335659007777	signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227
335659007778	The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530
335659007779	Catalytic site [active]
335659007780	The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530
335659007781	Yip1 domain; Region: Yip1; pfam04893
335659007782	signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227
335659007783	The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530
335659007784	Catalytic site [active]
335659007785	The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530
335659007786	chaperonin GroEL; Reviewed; Region: groEL; PRK12849
335659007787	GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344
335659007788	ring oligomerisation interface [polypeptide binding]; other site
335659007789	ATP/Mg binding site [chemical binding]; other site
335659007790	stacking interactions; other site
335659007791	hinge regions; other site
335659007792	Chaperonin 10 Kd subunit (cpn10 or GroES); Cpn10 cooperates with chaperonin 60 (cpn60 or GroEL), an ATPase, to assist the folding and assembly of proteins and is found in eubacterial cytosol, as well as in the matrix of mitochondria and chloroplasts. It...; Region: cpn10; cd00320
335659007793	oligomerisation interface [polypeptide binding]; other site
335659007794	mobile loop; other site
335659007795	roof hairpin; other site
335659007796	Usg-like family; Region: Usg; pfam06233
335659007797	Cupin domain; Region: Cupin_2; cl17218
335659007798	Nucleoside permease [Nucleotide transport and metabolism]; Region: NupC; COG1972
335659007799	Na+ dependent nucleoside transporter N-terminus; Region: Nucleos_tra2_N; pfam01773
335659007800	Nucleoside recognition; Region: Gate; pfam07670
335659007801	Na+ dependent nucleoside transporter C-terminus; Region: Nucleos_tra2_C; pfam07662
335659007802	H+ Antiporter protein; Region: 2A0121; TIGR00900
335659007803	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
335659007804	putative substrate translocation pore; other site
335659007805	putative NAD(P)-binding oxidoreductase; Provisional; Region: PRK09730
335659007806	classical (c) SDRs; Region: SDR_c; cd05233
335659007807	NAD(P) binding site [chemical binding]; other site
335659007808	active site
335659007809	Predicted proteasome-type protease [Posttranslational modification, protein turnover, chaperones]; Region: COG3484
335659007810	The Ntn hydrolases (N-terminal nucleophile) are a diverse superfamily of of enzymes that are activated autocatalytically via an N-terminally lcated nucleophilic amino acid.  N-terminal nucleophile (NTN-) hydrolase superfamily, which contains a...; Region: Ntn_hydrolase; cl00467
335659007811	active site
335659007812	Uncharacterized conserved protein [Function unknown]; Region: COG2128
335659007813	Carboxymuconolactone decarboxylase family; Region: CMD; pfam02627
335659007814	Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305
335659007815	Bacterial transglutaminase-like N-terminal region; Region: Bact_transglu_N; pfam08379
335659007816	Transglutaminase-like superfamily; Region: Transglut_core; pfam01841
335659007817	A predicted alpha-helical domain with a conserved ER motif; Region: Alpha-E; pfam04168
335659007818	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2307
335659007819	Uncharacterized conserved protein [Function unknown]; Region: COG2308
335659007820	Predicted nucleotide-utilizing enzyme related to molybdopterin-biosynthesis enzyme MoeA [General function prediction only]; Region: CinA; COG1058
335659007821	Competence-damaged protein. CinA is the first gene in the competence- inducible (cin) operon and is thought to be specifically required at some stage in the process of transformation. This domain is closely related to a domain, found in a variety of...; Region: cinA; cd00885
335659007822	putative MPT binding site; other site
335659007823	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
335659007824	active site
335659007825	CIMS - Cobalamine-independent methonine synthase, or MetE, C-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_C_terminal_like; cd03311
335659007826	substrate binding site [chemical binding]; other site
335659007827	methionine synthase; Provisional; Region: PRK01207
335659007828	THF binding site; other site
335659007829	zinc-binding site [ion binding]; other site
335659007830	GSH-dependent disulfide bond oxidoreductase; Provisional; Region: PRK13972
335659007831	GST_N family, Ure2p-like subfamily; composed of the Saccharomyces cerevisiae Ure2p and related GSTs. Ure2p is a regulator for nitrogen catabolism in yeast. It represses the expression of several gene products involved in the use of poor nitrogen sources...; Region: GST_N_Ure2p_like; cd03048
335659007832	C-terminal domain interface [polypeptide binding]; other site
335659007833	GSH binding site (G-site) [chemical binding]; other site
335659007834	dimer interface [polypeptide binding]; other site
335659007835	C-terminal, alpha helical domain of Escherichia coli YfcG Glutathione S-transferases and related uncharacterized proteins; Region: GST_C_YfcG_like; cd10291
335659007836	N-terminal domain interface [polypeptide binding]; other site
335659007837	putative dimer interface [polypeptide binding]; other site
335659007838	active site
335659007839	2-hydroxychromene-2-carboxylate isomerase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: NahD; COG3917
335659007840	DsbA family, 2-hydroxychromene-2-carboxylate (HCCA) isomerase subfamily; HCCA isomerase is a glutathione (GSH) dependent enzyme involved in the naphthalene catabolic pathway. It converts HCCA, a hemiketal formed spontaneously after ring cleavage of 1; Region: DsbA_HCCA_Iso; cd03022
335659007841	putative catalytic residue [active]
335659007842	NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604
335659007843	Quinone oxidoreductase (QOR); Region: QOR1; cd08241
335659007844	NAD(P) binding site [chemical binding]; other site
335659007845	enoyl-CoA hydratase; Provisional; Region: PRK08260
335659007846	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
335659007847	substrate binding site [chemical binding]; other site
335659007848	oxyanion hole (OAH) forming residues; other site
335659007849	trimer interface [polypeptide binding]; other site
335659007850	amidase; Provisional; Region: PRK07042
335659007851	Amidase; Region: Amidase; cl11426
335659007852	Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473
335659007853	M20 Peptidase Aminoacylase 1 subfamily; Region: M20_Acy1_like1; cd05666
335659007854	metal binding site [ion binding]; metal-binding site
335659007855	putative dimer interface [polypeptide binding]; other site
335659007856	Protein of unknown function (DUF1485); Region: DUF1485; pfam07364
335659007857	Uncharacterized conserved protein [Function unknown]; Region: COG5476
335659007858	MlrC C-terminus; Region: MlrC_C; pfam07171
335659007859	ATPase components of various ABC-type transport systems, contain duplicated ATPase [General function prediction only]; Region: COG1123
335659007860	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
335659007861	Walker A/P-loop; other site
335659007862	ATP binding site [chemical binding]; other site
335659007863	Q-loop/lid; other site
335659007864	ABC transporter signature motif; other site
335659007865	Walker B; other site
335659007866	D-loop; other site
335659007867	H-loop/switch region; other site
335659007868	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097
335659007869	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
335659007870	Walker A/P-loop; other site
335659007871	ATP binding site [chemical binding]; other site
335659007872	Q-loop/lid; other site
335659007873	ABC transporter signature motif; other site
335659007874	Walker B; other site
335659007875	D-loop; other site
335659007876	H-loop/switch region; other site
335659007877	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097
335659007878	nickel ABC transporter, permease subunit NikC; Region: nickel_nikC; TIGR02790
335659007879	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
335659007880	dimer interface [polypeptide binding]; other site
335659007881	conserved gate region; other site
335659007882	putative PBP binding loops; other site
335659007883	ABC-ATPase subunit interface; other site
335659007884	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601
335659007885	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
335659007886	dimer interface [polypeptide binding]; other site
335659007887	conserved gate region; other site
335659007888	putative PBP binding loops; other site
335659007889	ABC-ATPase subunit interface; other site
335659007890	D-amino acid dehydrogenase small subunit; Provisional; Region: PRK12409
335659007891	hydroxyglutarate oxidase; Provisional; Region: PRK11728
335659007892	glycine riboswitch as predicted by Rfam v8.1 (RF00504), score 58.79
335659007893	hypothetical protein; Provisional; Region: PRK07338
335659007894	M20 Peptidase Glutamate carboxypeptidase, a periplasmic enzyme; Region: M20_CPDG2; cd03885
335659007895	metal binding site [ion binding]; metal-binding site
335659007896	dimer interface [polypeptide binding]; other site
335659007897	ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747
335659007898	The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_16; cd08502
335659007899	ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747
335659007900	The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_16; cd08502
335659007901	Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; pfam13231
335659007902	drug resistance transporter, Bcr/CflA subfamily; Region: efflux_Bcr_CflA; TIGR00710
335659007903	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
335659007904	putative substrate translocation pore; other site
335659007905	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
335659007906	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
335659007907	enoyl-CoA hydratase; Provisional; Region: PRK05980
335659007908	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
335659007909	substrate binding site [chemical binding]; other site
335659007910	oxyanion hole (OAH) forming residues; other site
335659007911	trimer interface [polypeptide binding]; other site
335659007912	salicylate hydroxylase; Provisional; Region: PRK08163
335659007913	ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314
335659007914	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4391
335659007915	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
335659007916	Putative lysophospholipase; Region: Hydrolase_4; pfam12146
335659007917	serine acetyltransferase; Provisional; Region: cysE; PRK11132
335659007918	Serine acetyltransferase, N-terminal; Region: SATase_N; pfam06426
335659007919	Serine acetyltransferase (SAT): SAT catalyzes the CoA-dependent acetylation of the side chain hydroxyl group of L-serine to form O-acetylserine, as the first step of a two-step biosynthetic pathway in bacteria and plants leading to the formation of...; Region: LbH_SAT; cd03354
335659007920	trimer interface [polypeptide binding]; other site
335659007921	active site
335659007922	substrate binding site [chemical binding]; other site
335659007923	CoA binding site [chemical binding]; other site
335659007924	Protein of unknown function (DUF3126); Region: DUF3126; pfam11324
335659007925	Carbonic anhydrases/acetyltransferases, isoleucine patch superfamily [General function prediction only]; Region: PaaY; COG0663
335659007926	Gamma carbonic anhydrase-like: This family is composed of gamma carbonic anhydrase (CA), Ferripyochelin Binding Protein (FBP), E. coli paaY protein, and similar proteins. CAs are zinc-containing enzymes that catalyze the reversible hydration of carbon...; Region: LbH_gamma_CA_like; cd04645
335659007927	trimer interface [polypeptide binding]; other site
335659007928	putative metal binding site [ion binding]; other site
335659007929	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
335659007930	dimerization interface [polypeptide binding]; other site
335659007931	PAS fold; Region: PAS_7; pfam12860
335659007932	PAS domain S-box; Region: sensory_box; TIGR00229
335659007933	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
335659007934	putative active site [active]
335659007935	heme pocket [chemical binding]; other site
335659007936	Asp/Glu/Hydantoin racemase; Region: Asp_Glu_race; cl00518
335659007937	ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177
335659007938	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
335659007939	dimer interface [polypeptide binding]; other site
335659007940	conserved gate region; other site
335659007941	putative PBP binding loops; other site
335659007942	ABC-ATPase subunit interface; other site
335659007943	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
335659007944	dimer interface [polypeptide binding]; other site
335659007945	conserved gate region; other site
335659007946	putative PBP binding loops; other site
335659007947	ABC-ATPase subunit interface; other site
335659007948	Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416
335659007949	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199
335659007950	ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842
335659007951	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
335659007952	Walker A/P-loop; other site
335659007953	ATP binding site [chemical binding]; other site
335659007954	Q-loop/lid; other site
335659007955	ABC transporter signature motif; other site
335659007956	Walker B; other site
335659007957	D-loop; other site
335659007958	H-loop/switch region; other site
335659007959	TOBE domain; Region: TOBE_2; pfam08402
335659007960	Transcriptional regulators [Transcription]; Region: GntR; COG1802
335659007961	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
335659007962	DNA-binding site [nucleotide binding]; DNA binding site
335659007963	FCD domain; Region: FCD; pfam07729
335659007964	Uncharacterized conserved protein [Function unknown]; Region: COG3025
335659007965	Uncharacterized subgroup of the CYTH-like superfamily having an associated CHAD domain; Region: CYTH-like_Pase_CHAD; cd07756
335659007966	putative active site [active]
335659007967	putative metal binding residues [ion binding]; other site
335659007968	signature motif; other site
335659007969	putative triphosphate binding site [ion binding]; other site
335659007970	The CHAD domain is an alpha-helical domain functionally associated with some members of the adenylate cyclase family; Region: CHAD; smart00880
335659007971	Bacterial transglutaminase-like cysteine proteinase BTLCP; Region: BTLCP; pfam06035
335659007972	PilZ domain; Region: PilZ; pfam07238
335659007973	H+ Antiporter protein; Region: 2A0121; TIGR00900
335659007974	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
335659007975	putative substrate translocation pore; other site
335659007976	Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063
335659007977	Hypothetical enzyme TM0436 resembles the zinc-dependent alcohol dehydrogenases (ADH); Region: MDR_TM0436_like; cd08231
335659007978	catalytic Zn binding site [ion binding]; other site
335659007979	structural Zn binding site [ion binding]; other site
335659007980	tetramer interface [polypeptide binding]; other site
335659007981	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
335659007982	This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587
335659007983	active site
335659007984	metal binding site [ion binding]; metal-binding site
335659007985	Calcineurin-like phosphoesterase superfamily domain; Region: Metallophos_2; pfam12850
335659007986	Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149
335659007987	active site
335659007988	metal binding site [ion binding]; metal-binding site
335659007989	DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker  B motif; Region: DEADc; cd00268
335659007990	DEAD-like helicases superfamily; Region: DEXDc; smart00487
335659007991	ATP binding site [chemical binding]; other site
335659007992	Mg++ binding site [ion binding]; other site
335659007993	motif III; other site
335659007994	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
335659007995	nucleotide binding region [chemical binding]; other site
335659007996	ATP-binding site [chemical binding]; other site
335659007997	RNA recognition motif in the DbpA subfamily of prokaryotic DEAD-box rRNA helicases; Region: RRM_DbpA; cd12252
335659007998	RNA binding site [nucleotide binding]; other site
335659007999	Acetyltransferases [General function prediction only]; Region: RimI; COG0456
335659008000	Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583
335659008001	Coenzyme A binding pocket [chemical binding]; other site
335659008002	Secreted repeat of unknown function; Region: Lipoprotein_15; pfam03640
335659008003	Secreted repeat of unknown function; Region: Lipoprotein_15; pfam03640
335659008004	Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305
335659008005	Transglutaminase-like superfamily; Region: Transglut_core; pfam01841
335659008006	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5388
335659008007	PAS domain; Region: PAS_5; pfam07310
335659008008	Rhomboid family; Region: Rhomboid; cl11446
335659008009	The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair_10; cd04623
335659008010	FOG: CBS domain [General function prediction only]; Region: COG0517
335659008011	hypothetical protein; Provisional; Region: PRK10279
335659008012	Patatins and Phospholipases; Region: Patatin_and_cPLA2; cl11396
335659008013	nucleophile elbow; other site
335659008014	Medium chain dehydrogenases/reductase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR6; cd08272
335659008015	NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604
335659008016	putative NAD(P) binding site [chemical binding]; other site
335659008017	Transcriptional regulator [Transcription]; Region: LysR; COG0583
335659008018	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
335659008019	LysR substrate binding domain; Region: LysR_substrate; pfam03466
335659008020	dimerization interface [polypeptide binding]; other site
335659008021	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
335659008022	Acyl-CoA dehydrogenase, N-terminal domain; Region: Acyl-CoA_dh_N; pfam02771
335659008023	Acyl-CoA dehydrogenase; Region: ACAD; cd00567
335659008024	active site
335659008025	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
335659008026	putative DNA binding site [nucleotide binding]; other site
335659008027	putative Zn2+ binding site [ion binding]; other site
335659008028	V4R domain; Region: V4R; cl15268
335659008029	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
335659008030	Acyl-CoA dehydrogenase, N-terminal domain; Region: Acyl-CoA_dh_N; pfam02771
335659008031	Acyl-CoA dehydrogenase; Region: ACAD; cd00567
335659008032	active site
335659008033	PAS domain S-box; Region: sensory_box; TIGR00229
335659008034	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
335659008035	putative active site [active]
335659008036	heme pocket [chemical binding]; other site
335659008037	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
335659008038	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
335659008039	metal binding site [ion binding]; metal-binding site
335659008040	active site
335659008041	I-site; other site
335659008042	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
335659008043	Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680
335659008044	Beta-lactamase; Region: Beta-lactamase; pfam00144
335659008045	Nitroreductase-like family which includes NADH oxidase and arsenite oxidiase. NADH oxidase catalyses the oxidation of NAD(P)H and accepts a wide broad range of compounds as electron acceptors, such as nitrocompound. Arsenite oxidase in a...; Region: Arsenite_oxidase; cd02135
335659008046	putative FMN binding site [chemical binding]; other site
335659008047	Autotransporter-associated beta strand repeat; Region: Autotrns_rpt; pfam12951
335659008048	Autotransporter-associated beta strand repeat; Region: Autotrns_rpt; cl15373
335659008049	Uncharacterized protein with a C-terminal OMP (outer membrane protein) domain [Function unknown]; Region: COG4625
335659008050	Autotransporter beta-domain; Region: Autotransporter; smart00869
335659008051	threonyl-tRNA synthetase; Reviewed; Region: thrS; PRK00413
335659008052	TGS _ThrRS_N:  ThrRS (threonyl-tRNA Synthetase)  is a class II tRNA synthetase that couples threonine to its cognate tRNA.  In addition to its catalytic and anticodon-binding domains, ThrRS has an N-terminal TGS domain, named after the ThrRS, GTPase, and...; Region: TGS_ThrRS_N; cd01667
335659008053	Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863
335659008054	Threonyl-tRNA synthetase (ThrRS) class II core catalytic domain. ThrRS is a homodimer. It is responsible for the attachment of threonine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ThrRS_core; cd00771
335659008055	active site
335659008056	dimer interface [polypeptide binding]; other site
335659008057	motif 1; other site
335659008058	motif 2; other site
335659008059	motif 3; other site
335659008060	ThrRS Threonyl-anticodon binding domain. ThrRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: ThrRS_anticodon; cd00860
335659008061	anticodon binding site; other site
335659008062	Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814
335659008063	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
335659008064	putative substrate translocation pore; other site
335659008065	Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531
335659008066	hypothetical protein; Validated; Region: PRK00041
335659008067	Predicted periplasmic protein [Function unknown]; Region: COG3904
335659008068	NifU homolog involved in Fe-S cluster formation [Energy production and conversion]; Region: IscU; COG0822
335659008069	Iron-sulfur cluster scaffold-like proteins; Region: IscU_like; cd06664
335659008070	trimerization site [polypeptide binding]; other site
335659008071	active site
335659008072	GTP cyclohydrolase I; Provisional; Region: PLN03044
335659008073	GTP cyclohydrolase I; Provisional; Region: folE; PRK09347
335659008074	active site
335659008075	phosphoribosyl-AMP cyclohydrolase; Reviewed; Region: hisI; PRK00051
335659008076	lysozyme_like domain.  This contains several members including Soluble Lytic Transglycosylases (SLT), Goose Egg-White Lysozymes (GEWL), Hen Egg-White Lysozymes (HEWL), chitinases, bacteriophage lambda lysozymes, endolysins, autolysins, and chitosanases; Region: lysozyme_like; cl00222
335659008077	catalytic residue [active]
335659008078	Uncharacterized protein conserved in bacteria (DUF2336); Region: DUF2336; pfam10098
335659008079	Hpt domain; Region: Hpt; pfam01627
335659008080	putative binding surface; other site
335659008081	active site
335659008082	FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784
335659008083	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
335659008084	active site
335659008085	phosphorylation site [posttranslational modification]
335659008086	intermolecular recognition site; other site
335659008087	dimerization interface [polypeptide binding]; other site
335659008088	Protein of unknown function (DUF2975); Region: DUF2975; pfam11188
335659008089	Predicted transcriptional regulator [Transcription]; Region: COG3655
335659008090	salt bridge; other site
335659008091	non-specific DNA binding site [nucleotide binding]; other site
335659008092	sequence-specific DNA binding site [nucleotide binding]; other site
335659008093	inorganic polyphosphate/ATP-NAD kinase; Reviewed; Region: ppnK; PRK04761
335659008094	Carboxypeptidase C (cathepsin A) [Amino acid transport and metabolism]; Region: COG2939
335659008095	Serine carboxypeptidase; Region: Peptidase_S10; cl08270
335659008096	Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680
335659008097	Beta-lactamase; Region: Beta-lactamase; pfam00144
335659008098	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
335659008099	TPR motif; other site
335659008100	TPR repeat; Region: TPR_11; pfam13414
335659008101	binding surface
335659008102	Opacity protein and related surface antigens [Cell envelope biogenesis, outer membrane]; Region: COG3637
335659008103	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
335659008104	dimerization interface [polypeptide binding]; other site
335659008105	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
335659008106	Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283
335659008107	dimer interface [polypeptide binding]; other site
335659008108	putative CheW interface [polypeptide binding]; other site
335659008109	Methyltransferase domain; Region: Methyltransf_23; pfam13489
335659008110	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
335659008111	S-adenosylmethionine binding site [chemical binding]; other site
335659008112	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
335659008113	S-adenosylmethionine binding site [chemical binding]; other site
335659008114	DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182
335659008115	active site
335659008116	catalytic residues [active]
335659008117	DNA binding site [nucleotide binding]
335659008118	Int/Topo IB signature motif; other site
335659008119	Helix-turn-helix domain; Region: HTH_17; pfam12728
335659008120	SOS-response transcriptional repressors (RecA-mediated autopeptidases) [Transcription / Signal transduction mechanisms]; Region: LexA; COG1974
335659008121	'SWI3, ADA2, N-CoR and TFIIIB' DNA-binding domains. Tandem copies of the domain bind telomeric DNA tandem repeatsas part of the capping complex. Binding is sequence dependent for repeats which contain the G/C rich motif [C2-3 A (CA)1-6]. The...; Region: SANT; cd00167
335659008122	DNA binding site [nucleotide binding]
335659008123	TSCPD domain; Region: TSCPD; cl14834
335659008124	ParB-like nuclease domain; Region: ParBc; cl02129
335659008125	Prim_Pol: Primase-polymerase (primpol) domain of the type found in bifunctional replicases from archaeal plasmids, including ORF904 protein of the crenarchaeal plasmid pRN1 from Sulfolobus islandicus (pRN1 primpol). These primpol domains belong to the...; Region: Prim_Pol; cd04859
335659008126	polymerase nucleotide-binding site; other site
335659008127	DNA-binding residues [nucleotide binding]; DNA binding site
335659008128	nucleotide binding site [chemical binding]; other site
335659008129	primase nucleotide-binding site [nucleotide binding]; other site
335659008130	D5 N terminal like; Region: D5_N; smart00885
335659008131	phage/plasmid primase, P4 family, C-terminal domain; Region: primase_Cterm; TIGR01613
335659008132	Poxvirus D5 protein-like; Region: Pox_D5; pfam03288
335659008133	N-Utilization Substance G (NusG) N-terminal (NGN) domain Superfamily; Region: NGN; cl02766
335659008134	Protein of unknown function (DUF3606); Region: DUF3606; pfam12244
335659008135	Restriction endonuclease [Defense mechanisms]; Region: McrA; COG1403
335659008136	HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085
335659008137	active site
335659008138	Plasmid maintenance system antidote protein [General function prediction only]; Region: VapI; COG3093
335659008139	Helix-turn-helix domain; Region: HTH_38; pfam13936
335659008140	Phage terminase-like protein, large subunit [General function prediction only]; Region: COG4626
335659008141	Phage-related protein [Function unknown]; Region: COG4695; cl01923
335659008142	Phage portal protein; Region: Phage_portal; pfam04860
335659008143	Caudovirus prohead protease; Region: Peptidase_U35; pfam04586
335659008144	phage major capsid protein, HK97 family; Region: major_cap_HK97; TIGR01554
335659008145	Phage capsid family; Region: Phage_capsid; pfam05065
335659008146	GDSL-like Lipase/Acylhydrolase family; Region: Lipase_GDSL_2; pfam13472
335659008147	Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170
335659008148	phage conserved hypothetical protein, phiE125 gp8 family; Region: phage_chp_gp8; TIGR02215
335659008149	Head-Tail Connector Protein gp6 of Bacteriophage HK97 and similar proteins; Region: gp6; cd08054
335659008150	Head-Tail Connector Protein gp6 of Bacteriophage HK97 and similar proteins; Region: gp6; cd08054
335659008151	oligomerization interface [polypeptide binding]; other site
335659008152	Phage head-tail joining protein; Region: Phage_H_T_join; pfam05521
335659008153	Protein of unknown function (DUF3168); Region: DUF3168; pfam11367
335659008154	Phage major tail protein 2; Region: Phage_tail_2; pfam06199
335659008155	Protein of unknown function (DUF3356); Region: DUF3356; pfam11836
335659008156	Bacteriophage protein of unknown function (DUF646); Region: DUF646; cl12124
335659008157	Putative phage tail protein; Region: Phage-tail_3; pfam13550
335659008158	Domain of unknown function (DUF303); Region: DUF303; pfam03629
335659008159	D-alanyl-D-alanine carboxypeptidase; Region: Peptidase_M15_4; pfam13539
335659008160	membrane protein P6; Region: PHA01399
335659008161	Adenylation domain of Mycobacterium tuberculosis LigD and LigC-like ATP-dependent DNA ligases; Region: Adenylation_DNA_ligase_LigD_LigC; cd07906
335659008162	active site
335659008163	DNA binding site [nucleotide binding]
335659008164	rRNA methylase, putative, group 3; Region: rRNA_methyl_3; TIGR00186
335659008165	RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; smart00967
335659008166	SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588
335659008167	putative luciferase-like monooxygenase, FMN-dependent, CE1758 family; Region: LLM_CE1758_fam; TIGR04036
335659008168	Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892
335659008169	Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cd00347
335659008170	NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604
335659008171	Quinone oxidoreductase (QOR); Region: QOR1; cd08241
335659008172	NAD(P) binding site [chemical binding]; other site
335659008173	Superfamily I DNA and RNA helicases [DNA replication, recombination, and repair]; Region: UvrD; COG0210
335659008174	Part of AAA domain; Region: AAA_19; pfam13245
335659008175	Family description; Region: UvrD_C_2; pfam13538
335659008176	Protein of unknown function (DUF1211); Region: DUF1211; pfam06736
335659008177	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3795
335659008178	potential protein location (hypothetical protein S23_28290 [Bradyrhizobium sp. S23321]) that overlaps RNA (tRNA-G)
335659008179	AAA domain; Region: AAA_17; pfam13207
335659008180	pyrimidine utilization protein D; Region: RutD; TIGR03611
335659008181	Uncharacterized conserved protein (DUF2048); Region: DUF2048; pfam09752
335659008182	Cupin domain; Region: Cupin_2; pfam07883
335659008183	TRAP-type C4-dicarboxylate transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: DctP; COG1638
335659008184	Bacterial extracellular solute-binding protein, family 7; Region: SBP_bac_7; cl15441
335659008185	DctM-like transporters; Region: DctM; pfam06808
335659008186	TRAP-type C4-dicarboxylate transport system, large permease component [Carbohydrate transport and metabolism]; Region: DctQ; COG1593
335659008187	TRAP-type C4-dicarboxylate transport system, small permease component [Carbohydrate transport and metabolism]; Region: DctM; COG3090
335659008188	Transcriptional regulators [Transcription]; Region: FadR; COG2186
335659008189	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
335659008190	DNA-binding site [nucleotide binding]; DNA binding site
335659008191	FCD domain; Region: FCD; pfam07729
335659008192	short chain dehydrogenase; Provisional; Region: PRK06138
335659008193	classical (c) SDRs; Region: SDR_c; cd05233
335659008194	NAD(P) binding site [chemical binding]; other site
335659008195	active site
335659008196	hypothetical protein; Provisional; Region: PRK11171
335659008197	Cupin domain; Region: Cupin_2; cl17218
335659008198	GDP-D-mannose dehydratase [Cell envelope biogenesis, outer membrane]; Region: Gmd; COG1089
335659008199	GDP-mannose 4,6 dehydratase, extended (e) SDRs; Region: GDP_MD_SDR_e; cd05260
335659008200	NADP-binding site; other site
335659008201	homotetramer interface [polypeptide binding]; other site
335659008202	substrate binding site [chemical binding]; other site
335659008203	homodimer interface [polypeptide binding]; other site
335659008204	active site
335659008205	GDP-fucose synthetase, extended (e) SDRs; Region: GDP_FS_SDR_e; cd05239
335659008206	GDP-4-keto-6-deoxymannose-3, 5-epimerase-4-reductase; Region: PLN02725
335659008207	NADP binding site [chemical binding]; other site
335659008208	active site
335659008209	putative substrate binding site [chemical binding]; other site
335659008210	Predicted membrane protein [Function unknown]; Region: COG4244
335659008211	Glucose / Sorbosone dehydrogenase; Region: GSDH; pfam07995
335659008212	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
335659008213	Major Facilitator Superfamily; Region: MFS_1; pfam07690
335659008214	putative substrate translocation pore; other site
335659008215	Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804
335659008216	CoA-transferase family III; Region: CoA_transf_3; pfam02515
335659008217	Prokaryotic protein of unknown function (DUF849); Region: DUF849; pfam05853
335659008218	YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448
335659008219	homotrimer interaction site [polypeptide binding]; other site
335659008220	putative active site [active]
335659008221	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
335659008222	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
335659008223	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
335659008224	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
335659008225	active site
335659008226	Acyl-CoA dehydrogenase (ACAD) 10 and 11, N-terminal domain, and similar proteins. This subfamily is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs); Region: ACAD10_11_like; cd05154
335659008227	putative active site [active]
335659008228	putative substrate binding site [chemical binding]; other site
335659008229	ATP binding site [chemical binding]; other site
335659008230	acetylornithine deacetylase; Provisional; Region: PRK07522
335659008231	M20 Peptidase acetylornithine deacetylase; Region: M20_ArgE; cd03894
335659008232	metal binding site [ion binding]; metal-binding site
335659008233	putative dimer interface [polypeptide binding]; other site
335659008234	3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653
335659008235	classical (c) SDRs; Region: SDR_c; cd05233
335659008236	NAD(P) binding site [chemical binding]; other site
335659008237	active site
335659008238	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
335659008239	catalytic core [active]
335659008240	3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK07231
335659008241	classical (c) SDRs; Region: SDR_c; cd05233
335659008242	NAD(P) binding site [chemical binding]; other site
335659008243	active site
335659008244	Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628
335659008245	Domain of unknown function DUF20; Region: UPF0118; pfam01594
335659008246	Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680
335659008247	Beta-lactamase; Region: Beta-lactamase; pfam00144
335659008248	potential protein location (hypothetical protein S23_28610 [Bradyrhizobium sp. S23321]) that overlaps RNA (tRNA-W)
335659008249	preprotein translocase subunit SecE; Reviewed; Region: secE; PRK07597
335659008250	transcription antitermination protein NusG; Validated; Region: nusG; PRK05609
335659008251	Bacterial N-Utilization Substance G (NusG) N-terminal (NGN) domain, subgroup 1; Region: NGN_Bact_1; cd09891
335659008252	putative homodimer interface [polypeptide binding]; other site
335659008253	NusG contains an NGN domain at its N-terminus and KOW motif at its C-terminus; Region: KOW_NusG; cd06091
335659008254	heterodimer interface [polypeptide binding]; other site
335659008255	homodimer interface [polypeptide binding]; other site
335659008256	50S ribosomal protein L11; Validated; Region: rplK; PRK00140
335659008257	Ribosomal protein L11. Ribosomal protein L11, together with proteins L10 and L7/L12, and 23S rRNA, form the L7/L12 stalk on the surface of the large subunit of the ribosome. The homologous eukaryotic cytoplasmic protein is also called 60S ribosomal...; Region: Ribosomal_L11; cd00349
335659008258	23S rRNA interface [nucleotide binding]; other site
335659008259	L7/L12 interface [polypeptide binding]; other site
335659008260	putative thiostrepton binding site; other site
335659008261	L25 interface [polypeptide binding]; other site
335659008262	Ribosomal protein L1.  The L1 protein, located near the E-site of the ribosome, forms part of the L1 stalk along with 23S rRNA.  In bacteria and archaea, L1 functions both as a ribosomal protein that binds rRNA, and as a translation repressor that binds...; Region: Ribosomal_L1; cd00403
335659008263	mRNA/rRNA interface [nucleotide binding]; other site
335659008264	Lactate dehydrogenase and related dehydrogenases [Energy production and conversion / Coenzyme metabolism / General function prediction only]; Region: LdhA; COG1052
335659008265	Hydroxy(phenyl)pyruvate Reductase, D-isomer-specific 2-hydroxyacid-related dehydrogenase; Region: HPPR; cd12156
335659008266	putative ligand binding site [chemical binding]; other site
335659008267	NAD binding site [chemical binding]; other site
335659008268	catalytic site [active]
335659008269	Ribosomal protein L10 family, L10 subfamily; composed of bacterial 50S ribosomal protein and eukaryotic mitochondrial 39S ribosomal protein, L10. L10 occupies the L7/L12 stalk of the ribosome. The N-terminal domain (NTD) of L10 interacts with L11 protein...; Region: Ribosomal_L10; cd05797
335659008270	23S rRNA interface [nucleotide binding]; other site
335659008271	Interface with L7/L12 ribosomal proteins [polypeptide binding]; other site
335659008272	Ribosomal protein L7/L12. Ribosomal protein L7/L12 refers to the large ribosomal subunit proteins L7 and L12, which are identical except that L7 is acetylated at the N terminus. It is a component of the L7/L12 stalk, which is located at the surface of...; Region: Ribosomal_L7_L12; cd00387
335659008273	L11 interface [polypeptide binding]; other site
335659008274	putative EF-Tu interaction site [polypeptide binding]; other site
335659008275	putative EF-G interaction site [polypeptide binding]; other site
335659008276	DNA-directed RNA polymerase subunit beta; Reviewed; Region: rpoB; PRK00405
335659008277	RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cl17585
335659008278	RNA polymerase Rpb2, domain 2; Region: RNA_pol_Rpb2_2; pfam04561
335659008279	RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cl17585
335659008280	RNA polymerase beta subunit external 1 domain; Region: RNA_pol_Rpb2_45; pfam10385
335659008281	RNA polymerase Rpb2, domain 6; Region: RNA_pol_Rpb2_6; pfam00562
335659008282	RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653
335659008283	RPB3 interaction site [polypeptide binding]; other site
335659008284	RPB1 interaction site [polypeptide binding]; other site
335659008285	RPB11 interaction site [polypeptide binding]; other site
335659008286	RPB10 interaction site [polypeptide binding]; other site
335659008287	RNA polymerase Rpb1, domain 1; Region: RNA_pol_Rpb1_1; pfam04997
335659008288	DNA-directed RNA polymerase, beta' subunit/160 kD subunit [Transcription]; Region: RpoC; COG0086
335659008289	RNA polymerase I subunit A N-terminus; Region: RPOLA_N; smart00663
335659008290	RNA polymerase Rpb1, domain 3; Region: RNA_pol_Rpb1_3; pfam04983
335659008291	RNA polymerase Rpb1, domain 4; Region: RNA_pol_Rpb1_4; pfam05000
335659008292	RNA polymerase Rpb1, domain 5; Region: RNA_pol_Rpb1_5; pfam04998
335659008293	Largest subunit of RNA polymerase (RNAP), C-terminal domain; Region: RNAP_largest_subunit_C; cl11429
335659008294	Rpb1 - Rpb6 interaction site [polypeptide binding]; other site
335659008295	Largest subunit of RNA polymerase (RNAP), C-terminal domain; Region: RNAP_largest_subunit_C; cl11429
335659008296	Largest subunit (beta') of Bacterial DNA-dependent RNA polymerase (RNAP), C-terminal domain; Region: RNAP_beta'_C; cd02655
335659008297	DNA binding site [nucleotide binding]
335659008298	Rpb1 (beta') - Rpb2 (beta) interaction site [polypeptide binding]; other site
335659008299	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
335659008300	Flavin containing amine oxidoreductase; Region: Amino_oxidase; pfam01593
335659008301	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
335659008302	S-adenosylmethionine binding site [chemical binding]; other site
335659008303	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
335659008304	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
335659008305	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
335659008306	Walker A/P-loop; other site
335659008307	ATP binding site [chemical binding]; other site
335659008308	Q-loop/lid; other site
335659008309	ABC transporter signature motif; other site
335659008310	Walker B; other site
335659008311	D-loop; other site
335659008312	H-loop/switch region; other site
335659008313	ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314
335659008314	2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases [Coenzyme metabolism / Energy production and conversion]; Region: UbiH; COG0654
335659008315	S12-like family, 30S ribosomal protein S12 subfamily; S12 is located at the interface of the large and small ribosomal subunits of prokaryotes, chloroplasts and mitochondria, where it plays an important role in both tRNA and ribosomal subunit...; Region: Ribosomal_S12; cd03368
335659008316	S17 interaction site [polypeptide binding]; other site
335659008317	S8 interaction site; other site
335659008318	16S rRNA interaction site [nucleotide binding]; other site
335659008319	streptomycin interaction site [chemical binding]; other site
335659008320	23S rRNA interaction site [nucleotide binding]; other site
335659008321	aminoacyl-tRNA interaction site (A-site) [nucleotide binding]; other site
335659008322	30S ribosomal protein S7; Validated; Region: PRK05302
335659008323	elongation factor G; Reviewed; Region: PRK00007
335659008324	Elongation factor G (EF-G) family involved in both the elongation and ribosome recycling phases of protein synthesis; Region: EF-G; cd01886
335659008325	G1 box; other site
335659008326	putative GEF interaction site [polypeptide binding]; other site
335659008327	GTP/Mg2+ binding site [chemical binding]; other site
335659008328	Switch I region; other site
335659008329	G2 box; other site
335659008330	G3 box; other site
335659008331	Switch II region; other site
335659008332	G4 box; other site
335659008333	G5 box; other site
335659008334	EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088
335659008335	EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434
335659008336	EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G.  Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713
335659008337	elongation factor Tu; Reviewed; Region: PRK00049
335659008338	Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884
335659008339	G1 box; other site
335659008340	GEF interaction site [polypeptide binding]; other site
335659008341	GTP/Mg2+ binding site [chemical binding]; other site
335659008342	Switch I region; other site
335659008343	G2 box; other site
335659008344	G3 box; other site
335659008345	Switch II region; other site
335659008346	G4 box; other site
335659008347	G5 box; other site
335659008348	EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697
335659008349	Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707
335659008350	Antibiotic Binding Site [chemical binding]; other site
335659008351	30S ribosomal protein S10; Reviewed; Region: rpsJ; PRK00596
335659008352	50S ribosomal protein L3; Validated; Region: rplC; PRK00001
335659008353	50S ribosomal protein L4; Provisional; Region: rplD; PRK05319
335659008354	50S ribosomal protein L23; Reviewed; Region: rplW; PRK05738
335659008355	50S ribosomal protein L2; Validated; Region: rplB; PRK09374
335659008356	Ribosomal Proteins L2, RNA binding domain; Region: Ribosomal_L2; pfam00181
335659008357	Ribosomal Proteins L2, C-terminal domain; Region: Ribosomal_L2_C; pfam03947
335659008358	30S ribosomal protein S19; Reviewed; Region: rpsS; PRK00357
335659008359	Ribosomal protein L22/L17e.  L22 (L17 in eukaryotes) is a core protein of the large ribosomal subunit.  It is the only ribosomal protein that interacts with all six domains of 23S rRNA, and is one of the proteins important for directing the proper...; Region: Ribosomal_L22; cd00336
335659008360	putative translocon binding site; other site
335659008361	protein-rRNA interface [nucleotide binding]; other site
335659008362	30S ribosomal protein S3; Reviewed; Region: rpsC; PRK00310
335659008363	K homology RNA-binding (KH) domain of the prokaryotic 30S small ribosomal subunit protein S3. S3  is part of the head region of the 30S ribosomal subunit and is believed to interact with mRNA as it threads its way from the latch into the channel.  The KH...; Region: 30S_S3_KH; cd02412
335659008364	G-X-X-G motif; other site
335659008365	Ribosomal protein S3, C-terminal domain; Region: Ribosomal_S3_C; pfam00189
335659008366	Ribosomal_L16_L10e: L16 is an essential protein in the large ribosomal subunit of bacteria, mitochondria, and chloroplasts. Large subunits that lack L16 are defective in peptidyl transferase activity, peptidyl-tRNA hydrolysis activity, association with...; Region: Ribosomal_L16_L10e; cd01433
335659008367	23S rRNA interface [nucleotide binding]; other site
335659008368	5S rRNA interface [nucleotide binding]; other site
335659008369	putative antibiotic binding site [chemical binding]; other site
335659008370	L25 interface [polypeptide binding]; other site
335659008371	L27 interface [polypeptide binding]; other site
335659008372	Ribosomal L29 protein/HIP.  L29 is a protein of the large ribosomal Subunit. A homolog, called heparin/heparan sulfate interacting protein (HIP), has also been identified in mammals.  L29 is located on the surface of the large ribosomal subunit, where it...; Region: Ribosomal_L29_HIP; cd00427
335659008373	putative translocon interaction site; other site
335659008374	23S rRNA interface [nucleotide binding]; other site
335659008375	signal recognition particle (SRP54) interaction site; other site
335659008376	L23 interface [polypeptide binding]; other site
335659008377	trigger factor interaction site; other site
335659008378	30S ribosomal protein S17; Reviewed; Region: rpsQ; PRK05610
335659008379	50S ribosomal protein L14; Validated; Region: rplN; PRK05483
335659008380	50S ribosomal protein L24; Reviewed; Region: rplX; PRK00004
335659008381	KOW motif of Ribosomal Protein L26; Region: KOW_RPL26; cd06089
335659008382	RNA binding site [nucleotide binding]; other site
335659008383	50S ribosomal protein L5; Validated; Region: rplE; PRK00010
335659008384	Ribosomal protein L5; Region: Ribosomal_L5; pfam00281
335659008385	ribosomal L5P family C-terminus; Region: Ribosomal_L5_C; pfam00673
335659008386	30S ribosomal protein S14; Reviewed; Region: rpsN; PRK08881
335659008387	30S ribosomal protein S8; Validated; Region: rpsH; PRK00136
335659008388	50S ribosomal protein L6; Validated; Region: rplF; PRK05498
335659008389	Ribosomal protein L6; Region: Ribosomal_L6; pfam00347
335659008390	Ribosomal protein L6; Region: Ribosomal_L6; pfam00347
335659008391	Ribosomal L18/L5e:  L18 (L5e) is a ribosomal protein found in the central protuberance (CP) of the large subunit. L18 binds 5S rRNA and induces a conformational change that stimulates the binding of L5 to 5S rRNA. Association of 5S rRNA with 23S rRNA...; Region: Ribosomal_L18_L5e; cd00432
335659008392	5S rRNA interface [nucleotide binding]; other site
335659008393	23S rRNA interface [nucleotide binding]; other site
335659008394	L5 interface [polypeptide binding]; other site
335659008395	30S ribosomal protein S5; Validated; Region: rpsE; PRK00550
335659008396	Ribosomal protein S5, N-terminal domain; Region: Ribosomal_S5; pfam00333
335659008397	Ribosomal protein S5, C-terminal domain; Region: Ribosomal_S5_C; pfam03719
335659008398	Ribosomal protein L30, which is found in eukaryotes and prokaryotes but not in archaea, is one of the smallest ribosomal proteins with a molecular mass of about 7kDa. L30 binds the 23SrRNA as well as the 5S rRNA and is one of five ribosomal proteins that...; Region: Ribosomal_L30; cd01658
335659008399	23S rRNA binding site [nucleotide binding]; other site
335659008400	50S ribosomal protein L15; Reviewed; Region: rplO; PRK05592
335659008401	preprotein translocase subunit SecY; Reviewed; Region: secY; PRK09204
335659008402	SecY translocase; Region: SecY; pfam00344
335659008403	adenylate kinase; Provisional; Region: PRK13808
335659008404	Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for...; Region: ADK; cd01428
335659008405	AMP-binding site [chemical binding]; other site
335659008406	ATP-AMP (Ap5A)-binding site [chemical binding]; other site
335659008407	Ribosomal protein S13 [Translation, ribosomal structure and biogenesis]; Region: RpsM; COG0099
335659008408	30S ribosomal protein S13; Region: bact_S13; TIGR03631
335659008409	30S ribosomal protein S11; Validated; Region: PRK05309
335659008410	DNA-directed RNA polymerase subunit alpha; Provisional; Region: PRK05182
335659008411	N-terminal domain of the Alpha subunit of Bacterial RNA polymerase; Region: RNAP_alpha_NTD; cd06928
335659008412	alphaNTD - beta interaction site [polypeptide binding]; other site
335659008413	alphaNTD homodimer interface [polypeptide binding]; other site
335659008414	alphaNTD - beta' interaction site [polypeptide binding]; other site
335659008415	Bacterial RNA polymerase, alpha chain C terminal domain; Region: RNA_pol_A_CTD; pfam03118
335659008416	50S ribosomal protein L17; Validated; Region: rplQ; PRK05591
335659008417	3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK12825
335659008418	classical (c) SDRs; Region: SDR_c; cd05233
335659008419	NAD(P) binding site [chemical binding]; other site
335659008420	active site
335659008421	Protein of unknown function (DUF1330); Region: DUF1330; cl02288
335659008422	ClC chloride channel family. These protein sequences, closely related to the ClC Eric family, are putative halogen ion (Cl-, Br- and I-) transport proteins found in eubacteria. They belong to the ClC superfamily of chloride ion channels, which share a...; Region: EriC_like; cd01034
335659008423	Chloride channel protein EriC [Inorganic ion transport and metabolism]; Region: EriC; COG0038
335659008424	putative ion selectivity filter; other site
335659008425	putative pore gating glutamate residue; other site
335659008426	putative H+/Cl- coupling transport residue; other site
335659008427	Arginate lyase and other MDR family members; Region: AL_MDR; cd08252
335659008428	zinc-binding alcohol dehydrogenase family protein; Region: adh_fam_1; TIGR02817
335659008429	putative NAD(P) binding site [chemical binding]; other site
335659008430	dimer interface [polypeptide binding]; other site
335659008431	Predicted transcriptional regulators [Transcription]; Region: COG1733
335659008432	HxlR-like helix-turn-helix; Region: HxlR; pfam01638
335659008433	Phosphate-selective porin [Inorganic ion transport and metabolism]; Region: OprP; COG3746
335659008434	Phosphate-selective porin O and P; Region: Porin_O_P; pfam07396
335659008435	periplasmic serine protease, Do/DeqQ family; Region: degP_htrA_DO; TIGR02037
335659008436	Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365
335659008437	PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987
335659008438	protein binding site [polypeptide binding]; other site
335659008439	PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987
335659008440	protein binding site [polypeptide binding]; other site
335659008441	recombination factor protein RarA; Reviewed; Region: PRK13342
335659008442	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
335659008443	Walker A motif; other site
335659008444	ATP binding site [chemical binding]; other site
335659008445	Walker B motif; other site
335659008446	arginine finger; other site
335659008447	MgsA AAA+ ATPase C terminal; Region: MgsA_C; pfam12002
335659008448	Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564
335659008449	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
335659008450	RNA binding surface [nucleotide binding]; other site
335659008451	Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869
335659008452	active site
335659008453	ATP12 chaperone protein; Region: ATP12; cl02228
335659008454	Flagellar hook-length control protein FliK; Region: Flg_hook; pfam02120
335659008455	Uncharacterized homolog of the cytoplasmic domain of flagellar protein FhlB [Function unknown]; Region: COG2257
335659008456	Beta-lactamase class D [Defense mechanisms]; Region: COG2602
335659008457	Uncharacterized conserved protein [Function unknown]; Region: COG2128
335659008458	Domain of unknown function (DUF4260); Region: DUF4260; pfam14079
335659008459	Acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta) [Lipid metabolism]; Region: COG4799
335659008460	malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682
335659008461	Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; cl17345
335659008462	GST_N family, Saccharomyces cerevisiae GTT1-like subfamily; composed of predominantly uncharacterized proteins with similarity to the S. cerevisiae GST protein, GTT1, and the Schizosaccharomyces pombe GST-III. GSTs are cytosolic dimeric proteins involved...; Region: GST_N_GTT1_like; cd03046
335659008463	putative C-terminal domain interface [polypeptide binding]; other site
335659008464	putative GSH binding site (G-site) [chemical binding]; other site
335659008465	Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625
335659008466	putative dimer interface [polypeptide binding]; other site
335659008467	C-terminal, alpha helical domain of an unknown subfamily 8 of Glutathione S-transferases; Region: GST_C_8; cd03207
335659008468	dimer interface [polypeptide binding]; other site
335659008469	N-terminal domain interface [polypeptide binding]; other site
335659008470	putative substrate binding pocket (H-site) [chemical binding]; other site
335659008471	Putative lysophospholipase; Region: Hydrolase_4; pfam12146
335659008472	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
335659008473	homoserine O-acetyltransferase; Provisional; Region: metX; cl17114
335659008474	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
335659008475	dimerization interface [polypeptide binding]; other site
335659008476	putative DNA binding site [nucleotide binding]; other site
335659008477	putative Zn2+ binding site [ion binding]; other site
335659008478	NIPSNAP; Region: NIPSNAP; pfam07978
335659008479	Uncharacterized enzyme involved in biosynthesis of extracellular polysaccharides [General function prediction only]; Region: COG2329
335659008480	Phosphoenolpyruvate phosphomutase; Region: PEP_mutase; pfam13714
335659008481	Members of the ICL/PEPM enzyme family catalyze either P-C or C-C bond formation/cleavage. Known members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate hydrolase (OAH), isocitrate...; Region: ICL_PEPM; cd00377
335659008482	tetramer interface [polypeptide binding]; other site
335659008483	active site
335659008484	Mg2+/Mn2+ binding site [ion binding]; other site
335659008485	Predicted membrane protein [Function unknown]; Region: COG2860
335659008486	UPF0126 domain; Region: UPF0126; pfam03458
335659008487	UPF0126 domain; Region: UPF0126; pfam03458
335659008488	Cytochrome c; Region: Cytochrom_C; pfam00034
335659008489	Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010
335659008490	Cytochrome c; Region: Cytochrom_C; pfam00034
335659008491	Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010
335659008492	Cytochrome C oxidase, cbb3-type, subunit III; Region: Cytochrome_CBB3; pfam13442
335659008493	indolepyruvate ferredoxin oxidoreductase; Validated; Region: PRK09193
335659008494	Pyrimidine (PYR) binding domain of pyruvate ferredoxin oxidoreductase (PFOR), indolepyruvate ferredoxin oxidoreductase alpha subunit (IOR-alpha), and related proteins; Region: TPP_PYR_PFOR_IOR-alpha_like; cd07034
335659008495	dimer interface [polypeptide binding]; other site
335659008496	PYR/PP interface [polypeptide binding]; other site
335659008497	TPP binding site [chemical binding]; other site
335659008498	substrate binding site [chemical binding]; other site
335659008499	Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cl01629
335659008500	TPP-binding site [chemical binding]; other site
335659008501	Pyruvate ferredoxin/flavodoxin oxidoreductase; Region: POR; cl00546
335659008502	acetyl-CoA acetyltransferase; Provisional; Region: PRK08142
335659008503	Thiolase domain associated with sterol carrier protein (SCP)-x isoform and related proteins; SCP-2  has multiple roles in intracellular lipid circulation and metabolism. The N-terminal presequence in the SCP-x isoform represents a peroxisomal...; Region: SCP-x_thiolase; cd00829
335659008504	active site
335659008505	Predicted nucleic-acid-binding protein containing a Zn-ribbon [General function prediction only]; Region: COG1545
335659008506	Rubredoxin-like zinc ribbon domain (DUF35_N); Region: DUF35_N; pfam12172
335659008507	DUF35 OB-fold domain; Region: DUF35; pfam01796
335659008508	The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509
335659008509	HDE_HSD  The R-hydratase-like hot dog fold of the 17-beta-hydroxysteriod dehydrogenase (HSD), and Hydratase-Dehydrogenase-Epimerase (HDE) proteins.  Other enzymes with this fold include MaoC dehydratase, and the fatty acid synthase beta subunit; Region: HDE_HSD; cd03448
335659008510	dimer interaction site [polypeptide binding]; other site
335659008511	substrate-binding tunnel; other site
335659008512	active site
335659008513	catalytic site [active]
335659008514	substrate binding site [chemical binding]; other site
335659008515	(3R)-hydroxyacyl-CoA dehydrogenase-like, classical(c)-like SDRs; Region: hydroxyacyl-CoA-like_DH_SDR_c-like; cd05353
335659008516	homodimer interface [polypeptide binding]; other site
335659008517	3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653
335659008518	NAD binding site [chemical binding]; other site
335659008519	active site
335659008520	Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329
335659008521	Dihydrodipicolinate synthase family; Region: DHDPS-like; cd00408
335659008522	inhibitor site; inhibition site
335659008523	active site
335659008524	dimer interface [polypeptide binding]; other site
335659008525	catalytic residue [active]
335659008526	Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447
335659008527	nudix motif; other site
335659008528	EamA-like transporter family; Region: EamA; pfam00892
335659008529	putative DMT superfamily transporter inner membrane protein; Provisional; Region: PRK11272
335659008530	Four helix bundle sensory module for signal transduction; Region: 4HB_MCP_1; pfam12729
335659008531	HAMP domain; Region: HAMP; pfam00672
335659008532	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
335659008533	PAS fold; Region: PAS_3; pfam08447
335659008534	putative active site [active]
335659008535	heme pocket [chemical binding]; other site
335659008536	PAS fold; Region: PAS_4; pfam08448
335659008537	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459
335659008538	putative active site [active]
335659008539	heme pocket [chemical binding]; other site
335659008540	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
335659008541	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
335659008542	ATP binding site [chemical binding]; other site
335659008543	Mg2+ binding site [ion binding]; other site
335659008544	G-X-G motif; other site
335659008545	pyruvate carboxylase subunit B; Provisional; Region: PRK14042
335659008546	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
335659008547	This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587
335659008548	active site
335659008549	metal binding site [ion binding]; metal-binding site
335659008550	ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600
335659008551	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
335659008552	dimer interface [polypeptide binding]; other site
335659008553	conserved gate region; other site
335659008554	putative PBP binding loops; other site
335659008555	ABC-ATPase subunit interface; other site
335659008556	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cl17432
335659008557	NMT1/THI5 like; Region: NMT1; pfam09084
335659008558	membrane-bound complex binding site; other site
335659008559	hinge residues; other site
335659008560	ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600
335659008561	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
335659008562	dimer interface [polypeptide binding]; other site
335659008563	conserved gate region; other site
335659008564	putative PBP binding loops; other site
335659008565	ABC-ATPase subunit interface; other site
335659008566	ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116
335659008567	ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293
335659008568	Q-loop/lid; other site
335659008569	ABC transporter signature motif; other site
335659008570	Walker B; other site
335659008571	D-loop; other site
335659008572	H-loop/switch region; other site
335659008573	Helix-turn-helix domain; Region: HTH_18; pfam12833
335659008574	Protein required for attachment to host cells; Region: Host_attach; pfam10116
335659008575	Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697
335659008576	EamA-like transporter family; Region: EamA; pfam00892
335659008577	EamA-like transporter family; Region: EamA; pfam00892
335659008578	Deoxyribodipyrimidine photolyase [DNA replication, recombination, and repair]; Region: PhrB; COG0415
335659008579	DNA photolyase; Region: DNA_photolyase; pfam00875
335659008580	Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450
335659008581	Peroxiredoxin (PRX) family, 1-cys PRX subfamily; composed of PRXs containing only one conserved cysteine, which serves as the peroxidatic cysteine. They are homodimeric thiol-specific antioxidant (TSA) proteins that confer a protective role in cells by...; Region: PRX_1cys; cd03016
335659008582	dimer interface [polypeptide binding]; other site
335659008583	decamer (pentamer of dimers) interface [polypeptide binding]; other site
335659008584	catalytic triad [active]
335659008585	Type I phosphodiesterase / nucleotide pyrophosphatase; Region: Phosphodiest; pfam01663
335659008586	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
335659008587	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
335659008588	DNA binding residues [nucleotide binding]
335659008589	dimerization interface [polypeptide binding]; other site
335659008590	MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
335659008591	ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577
335659008592	FtsX-like permease family; Region: FtsX; pfam02687
335659008593	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
335659008594	ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255
335659008595	Walker A/P-loop; other site
335659008596	ATP binding site [chemical binding]; other site
335659008597	Q-loop/lid; other site
335659008598	ABC transporter signature motif; other site
335659008599	Walker B; other site
335659008600	D-loop; other site
335659008601	H-loop/switch region; other site
335659008602	RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730
335659008603	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
335659008604	HlyD family secretion protein; Region: HlyD_3; pfam13437
335659008605	Response regulator [Signal transduction mechanisms]; Region: TtrR; COG4566
335659008606	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
335659008607	active site
335659008608	phosphorylation site [posttranslational modification]
335659008609	intermolecular recognition site; other site
335659008610	dimerization interface [polypeptide binding]; other site
335659008611	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
335659008612	dimerization interface [polypeptide binding]; other site
335659008613	DNA binding residues [nucleotide binding]
335659008614	curlin minor subunit CsgB; Provisional; Region: csgB; PRK10101
335659008615	Curlin associated repeat; Region: Curlin_rpt; pfam07012
335659008616	curlin minor subunit CsgB; Provisional; Region: csgB; PRK10101
335659008617	Curlin associated repeat; Region: Curlin_rpt; pfam07012
335659008618	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
335659008619	Coenzyme A binding pocket [chemical binding]; other site
335659008620	putative beta-ketoacyl acyl carrier protein [ACP] reductase (BKR)-like, SDR; Region: BKR_like_SDR_like; cd05344
335659008621	3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK06463
335659008622	putative NAD(P) binding site [chemical binding]; other site
335659008623	putative active site [active]
335659008624	Opacity protein and related surface antigens [Cell envelope biogenesis, outer membrane]; Region: COG3637
335659008625	Predicted transcriptional regulators [Transcription]; Region: ArsR; COG0640
335659008626	putative Zn2+ binding site [ion binding]; other site
335659008627	putative DNA binding site [nucleotide binding]; other site
335659008628	Putative hydrophobic ligand-binding SRPBCC domain of an uncharacterized subgroup of CalC- and Aha1-like proteins; Region: SRPBCC_CalC_Aha1-like_1; cd08894
335659008629	putative hydrophobic ligand binding site [chemical binding]; other site
335659008630	Type I periplasmic ligand-binding domain of uncharacterized ABC (ATPase Binding Cassette)-type active transport systems that are predicted to be involved in uptake of amino acids, peptides, or inorganic ions; Region: PBP1_ABC_ligand_binding_like_8; cd06343
335659008631	Periplasmic binding protein; Region: Peripla_BP_6; pfam13458
335659008632	putative ligand binding site [chemical binding]; other site
335659008633	Tripartite tricarboxylate transporter family receptor; Region: TctC; cl17792
335659008634	Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804
335659008635	CoA-transferase family III; Region: CoA_transf_3; pfam02515
335659008636	Protein of unknown function (DUF1643); Region: DUF1643; cl01787
335659008637	Transcriptional regulator [Transcription]; Region: IclR; COG1414
335659008638	helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346
335659008639	Periplasmic binding protein; Region: Peripla_BP_6; pfam13458
335659008640	Periplasmic solute-binding domain of active transport proteins that belong to the type I periplasmic binding fold protein family; Region: PBP1_SBP_like_1; cd06327
335659008641	putative ligand binding site [chemical binding]; other site
335659008642	2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179
335659008643	Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557
335659008644	3-(3-hydroxyphenyl)propionate hydroxylase; Validated; Region: mhpA; PRK06183
335659008645	ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314
335659008646	ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683
335659008647	Type I periplasmic binding component of ABC (ATPase Binding Cassette)-type transport systems that are predicted to be involved in uptake of amino acids; Region: PBP1_ABC-type_HAAT_like; cd06333
335659008648	putative ligand binding site [chemical binding]; other site
335659008649	Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124
335659008650	Cytochrome P450; Region: p450; cl12078
335659008651	DNA-binding transcriptional activator MhpR; Provisional; Region: PRK09834
335659008652	helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346
335659008653	Bacterial transcriptional regulator; Region: IclR; pfam01614
335659008654	2,3-dihydroxybiphenyl 1,2-dioxygenase; Region: 23dbph12diox; TIGR03213
335659008655	N-terminal domain of 2,3-dihydroxybiphenyl 1,2-dioxygenase (BphC, EC 1.13.11.39) 1 from Rhodococcus globerulus P6 (BphC1-RGP6) and similar proteins; Region: BphC1-RGP6_N_like; cd07252
335659008656	C-terminal domain of 2,3-dihydroxybiphenyl 1,2-dioxygenase (BphC, EC 1.13.11.39) 1 from Rhodococcus globerulus P6 (BphC1-RGP6) and similar proteins; Region: BphC1-RGP6_C_like; cd07237
335659008657	active site
335659008658	Fe binding site [ion binding]; other site
335659008659	Metal-dependent hydrolases of the beta-lactamase superfamily III [General function prediction only]; Region: ElaC; COG1234
335659008660	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
335659008661	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
335659008662	active site
335659008663	phosphorylation site [posttranslational modification]
335659008664	intermolecular recognition site; other site
335659008665	dimerization interface [polypeptide binding]; other site
335659008666	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
335659008667	DNA binding residues [nucleotide binding]
335659008668	dimerization interface [polypeptide binding]; other site
335659008669	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054
335659008670	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585
335659008671	Histidine kinase; Region: HisKA_3; pfam07730
335659008672	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
335659008673	ATP binding site [chemical binding]; other site
335659008674	Mg2+ binding site [ion binding]; other site
335659008675	G-X-G motif; other site
335659008676	Protein of unknown function (DUF2380); Region: DUF3280; pfam11684
335659008677	Protein of unknown function (DUF2380); Region: DUF3280; pfam11684
335659008678	L-idonate 5-dehydrogenase; Provisional; Region: PRK09880
335659008679	L-idonate 5-dehydrogenase; Region: idonate-5-DH; cd08232
335659008680	putative NAD(P) binding site [chemical binding]; other site
335659008681	catalytic Zn binding site [ion binding]; other site
335659008682	gluconate 5-dehydrogenase; Provisional; Region: PRK07523
335659008683	gluconate 5-dehydrogenase (Ga5DH)-like, classical (c) SDRs; Region: Ga5DH-like_SDR_c; cd05347
335659008684	NADP binding site [chemical binding]; other site
335659008685	homodimer interface [polypeptide binding]; other site
335659008686	active site
335659008687	L-alanine-DL-glutamate epimerase and related enzymes of enolase superfamily [Cell envelope biogenesis, outer membrane / General function prediction only]; Region: COG4948
335659008688	Mandelate racemase (MR)-like subfamily of the enolase superfamily. Enzymes of this subgroup share three conserved carboxylate ligands for the essential divalent metal ion (usually Mg2+), two aspartates and a glutamate, and conserved catalytic residues; Region: MR_like; cd03316
335659008689	active site pocket [active]
335659008690	DNA-binding site [nucleotide binding]; DNA binding site
335659008691	Transcriptional regulators [Transcription]; Region: FadR; COG2186
335659008692	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl17414
335659008693	FCD domain; Region: FCD; pfam07729
335659008694	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
335659008695	D-galactonate transporter; Region: 2A0114; TIGR00893
335659008696	putative substrate translocation pore; other site
335659008697	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
335659008698	Na+/H+ antiporter NhaD and related arsenite permeases [Inorganic ion transport and metabolism]; Region: ArsB; COG1055
335659008699	Anion permease ArsB.  These permeases have been shown to export arsenate and antimonite in eubacteria and archaea.  A typical ArsB permease contains 8-13 transmembrane helices and can function either independently as a chemiosmotic transporter or as a...; Region: ArsB_permease; cd01118
335659008700	transmembrane helices; other site
335659008701	Major Facilitator Superfamily; Region: MFS_1; pfam07690
335659008702	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
335659008703	putative substrate translocation pore; other site
335659008704	Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204
335659008705	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
335659008706	intermolecular recognition site; other site
335659008707	active site
335659008708	dimerization interface [polypeptide binding]; other site
335659008709	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
335659008710	Walker A motif; other site
335659008711	ATP binding site [chemical binding]; other site
335659008712	Walker B motif; other site
335659008713	arginine finger; other site
335659008714	Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954
335659008715	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
335659008716	His Kinase A (phosphoacceptor) domain; Region: HisKA; smart00388
335659008717	dimer interface [polypeptide binding]; other site
335659008718	phosphorylation site [posttranslational modification]
335659008719	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
335659008720	ATP binding site [chemical binding]; other site
335659008721	Mg2+ binding site [ion binding]; other site
335659008722	G-X-G motif; other site
335659008723	Predicted membrane protein [Function unknown]; Region: COG2510
335659008724	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
335659008725	PAS fold; Region: PAS_3; pfam08447
335659008726	putative active site [active]
335659008727	heme pocket [chemical binding]; other site
335659008728	PAS domain S-box; Region: sensory_box; TIGR00229
335659008729	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
335659008730	putative active site [active]
335659008731	heme pocket [chemical binding]; other site
335659008732	PAS domain; Region: PAS_9; pfam13426
335659008733	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
335659008734	dimer interface [polypeptide binding]; other site
335659008735	phosphorylation site [posttranslational modification]
335659008736	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
335659008737	ATP binding site [chemical binding]; other site
335659008738	Mg2+ binding site [ion binding]; other site
335659008739	G-X-G motif; other site
335659008740	Response regulator receiver domain; Region: Response_reg; pfam00072
335659008741	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
335659008742	active site
335659008743	phosphorylation site [posttranslational modification]
335659008744	intermolecular recognition site; other site
335659008745	dimerization interface [polypeptide binding]; other site
335659008746	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4307
335659008747	Uncharacterized protein conserved in bacteria (DUF2248); Region: DUF2248; pfam10005
335659008748	Acetyl/propionyl-CoA carboxylase, alpha subunit [Lipid metabolism]; Region: COG4770
335659008749	Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289
335659008750	Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786
335659008751	Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; pfam02785
335659008752	The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850
335659008753	carboxyltransferase (CT) interaction site; other site
335659008754	biotinylation site [posttranslational modification]; other site
335659008755	Phosphoenolpyruvate phosphomutase; Region: PEP_mutase; pfam13714
335659008756	Members of the ICL/PEPM enzyme family catalyze either P-C or C-C bond formation/cleavage. Known members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate hydrolase (OAH), isocitrate...; Region: ICL_PEPM; cd00377
335659008757	tetramer interface [polypeptide binding]; other site
335659008758	active site
335659008759	Mg2+/Mn2+ binding site [ion binding]; other site
335659008760	acylphosphatase; Provisional; Region: PRK14421
335659008761	phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966
335659008762	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
335659008763	putative active site [active]
335659008764	heme pocket [chemical binding]; other site
335659008765	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
335659008766	dimer interface [polypeptide binding]; other site
335659008767	phosphorylation site [posttranslational modification]
335659008768	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
335659008769	ATP binding site [chemical binding]; other site
335659008770	Mg2+ binding site [ion binding]; other site
335659008771	G-X-G motif; other site
335659008772	Response regulator receiver domain; Region: Response_reg; pfam00072
335659008773	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
335659008774	active site
335659008775	phosphorylation site [posttranslational modification]
335659008776	intermolecular recognition site; other site
335659008777	dimerization interface [polypeptide binding]; other site
335659008778	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
335659008779	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
335659008780	dimerization interface [polypeptide binding]; other site
335659008781	Uncharacterized protein, 4-oxalocrotonate tautomerase homolog [General function prediction only]; Region: COG1942
335659008782	replicative DNA helicase; Provisional; Region: PRK05973
335659008783	Replicative DNA helicase [DNA replication, recombination, and repair]; Region: DnaB; COG0305
335659008784	lipoate-protein ligase B; Provisional; Region: PRK14341
335659008785	hypothetical protein; Validated; Region: PRK06033
335659008786	Transcriptional regulator containing an amidase domain and an AraC-type DNA-binding HTH domain [Transcription]; Region: COG4977
335659008787	AraC transcriptional regulators having a Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GATase1_AraC_1; cd03137
335659008788	conserved cys residue [active]
335659008789	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
335659008790	Putative intracellular protease/amidase [General function prediction only]; Region: ThiJ; COG0693
335659008791	Type 1 glutamine amidotransferase (GATase1)-like domain found in a subgroup of proteins similar to PfpI from Pyrococcus furiosus; Region: GATase1_PfpI_2; cd03139
335659008792	conserved cys residue [active]
335659008793	Periplasmic binding protein; Region: Peripla_BP_6; pfam13458
335659008794	Periplasmic solute-binding domain of active transport proteins that belong to the type I periplasmic binding fold protein family; Region: PBP1_SBP_like_1; cd06327
335659008795	putative ligand binding site [chemical binding]; other site
335659008796	Putative GTPases (G3E family) [General function prediction only]; Region: COG0523
335659008797	CobW/HypB/UreG, nucleotide-binding domain; Region: cobW; pfam02492
335659008798	Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; smart00833
335659008799	Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726
335659008800	Catalytic NodB homology domain of rhizobial NodB-like proteins; Region: CE4_NodB_like_6s_7s; cd10917
335659008801	NodB motif; other site
335659008802	active site
335659008803	catalytic site [active]
335659008804	metal binding site [ion binding]; metal-binding site
335659008805	Catalytic NodB homology domain of rhizobial NodB-like proteins; Region: CE4_NodB_like_6s_7s; cd10917
335659008806	Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726
335659008807	NodB motif; other site
335659008808	active site
335659008809	catalytic site [active]
335659008810	metal binding site [ion binding]; metal-binding site
335659008811	Mg/Co/Ni transporter MgtE (contains CBS domain) [Inorganic ion transport and metabolism]; Region: MgtE; COG2239
335659008812	MgtE intracellular N domain; Region: MgtE_N; smart00924
335659008813	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domain in the magnesium transporter, MgtE.  MgtE and its homologs are found in eubacteria, archaebacteria, and eukaryota. Members of this family transport Mg2+ or other...; Region: CBS_pair_Mg_transporter; cd04606
335659008814	Divalent cation transporter; Region: MgtE; cl00786
335659008815	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
335659008816	non-specific DNA binding site [nucleotide binding]; other site
335659008817	salt bridge; other site
335659008818	sequence-specific DNA binding site [nucleotide binding]; other site
335659008819	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
335659008820	Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248
335659008821	active site
335659008822	catalytic tetrad [active]
335659008823	Protein of unknown function, DUF599; Region: DUF599; pfam04654
335659008824	GST_N family, unknown subfamily 1; composed of uncharacterized proteins, predominantly from bacteria, with similarity to GSTs. GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with...; Region: GST_N_1; cd03043
335659008825	Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625
335659008826	putative C-terminal domain interface [polypeptide binding]; other site
335659008827	putative GSH binding site (G-site) [chemical binding]; other site
335659008828	putative dimer interface [polypeptide binding]; other site
335659008829	C-terminal, alpha helical domain of an unknown subfamily 3 of Glutathione S-transferases; Region: GST_C_3; cd03194
335659008830	putative N-terminal domain interface [polypeptide binding]; other site
335659008831	putative dimer interface [polypeptide binding]; other site
335659008832	putative substrate binding pocket (H-site) [chemical binding]; other site
335659008833	Protein of unknown function (DUF1489); Region: DUF1489; pfam07370
335659008834	pantoate--beta-alanine ligase; Region: panC; TIGR00018
335659008835	Pantoate-beta-alanine ligase; Region: PanC; cd00560
335659008836	active site
335659008837	ATP-binding site [chemical binding]; other site
335659008838	pantoate-binding site; other site
335659008839	HXXH motif; other site
335659008840	ATPase MipZ; Region: MipZ; pfam09140
335659008841	ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042
335659008842	P-loop; other site
335659008843	Magnesium ion binding site [ion binding]; other site
335659008844	ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042
335659008845	Magnesium ion binding site [ion binding]; other site
335659008846	Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695
335659008847	Lipase.  Lipases are esterases that can hydrolyze long-chain acyl-triglycerides into di- and monoglycerides, glycerol, and free fatty acids at a water/lipid interface. A typical feature of lipases is "interfacial activation", the process of...; Region: Lipase; cl14883
335659008848	nucleophilic elbow; other site
335659008849	catalytic triad; other site
335659008850	von Willebrand factor type A domain; Region: VWA_2; pfam13519
335659008851	DnaJ domain or J-domain.  DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257
335659008852	HSP70 interaction site [polypeptide binding]; other site
335659008853	D-alanyl-D-alanine carboxypeptidase [Cell envelope biogenesis, outer membrane]; Region: DacC; COG1686
335659008854	Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872
335659008855	Sporulation related domain; Region: SPOR; pfam05036
335659008856	Phasin protein; Region: Phasin_2; pfam09361
335659008857	Uncharacterized conserved protein [Function unknown]; Region: COG2127
335659008858	ATP-dependent Clp protease ATP-binding subunit clpA; Region: ClpA; TIGR02639
335659008859	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
335659008860	Walker A motif; other site
335659008861	ATP binding site [chemical binding]; other site
335659008862	Walker B motif; other site
335659008863	arginine finger; other site
335659008864	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
335659008865	Walker A motif; other site
335659008866	ATP binding site [chemical binding]; other site
335659008867	Walker B motif; other site
335659008868	C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431
335659008869	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
335659008870	Major Facilitator Superfamily; Region: MFS_1; pfam07690
335659008871	putative substrate translocation pore; other site
335659008872	Cytochrome c; Region: Cytochrom_C; pfam00034
335659008873	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
335659008874	Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248
335659008875	active site
335659008876	catalytic tetrad [active]
335659008877	Helix-turn-helix domain; Region: HTH_18; pfam12833
335659008878	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
335659008879	Nitrilases, cyanide hydratase (CH)s, and similar proteins (class 1 nitrilases); Region: nitrilases_CHs; cd07564
335659008880	Predicted amidohydrolase [General function prediction only]; Region: COG0388
335659008881	putative active site [active]
335659008882	catalytic triad [active]
335659008883	putative dimer interface [polypeptide binding]; other site
335659008884	Haem-containing dehydratase; Region: Dehydratase_hem; pfam13816
335659008885	Predicted phosphatases [General function prediction only]; Region: Gph; COG0546
335659008886	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
335659008887	motif II; other site
335659008888	Protein of unknown function (DUF3121); Region: DUF3121; cl11879
335659008889	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
335659008890	This family is most closely related to the GT1 family of glycosyltransferases. ORF704 in E. coli has been shown to be involved in the biosynthesis of O-specific mannose homopolysaccharides; Region: GT1_ecORF704_like; cd03822
335659008891	Glycosyl hydrolase families: GH43, GH62, GH32, GH68; Region: GH43_62_32_68; cl14647
335659008892	active site
335659008893	Bacterial extracellular solute-binding protein, family 7; Region: SBP_bac_7; cl15441
335659008894	Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741
335659008895	Lytic Transglycosylase (LT)  and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL).  LTs...; Region: LT_GEWL; cd00254
335659008896	N-acetyl-D-glucosamine binding site [chemical binding]; other site
335659008897	catalytic residue [active]
335659008898	Sporulation related domain; Region: SPOR; pfam05036
335659008899	AzlC protein; Region: AzlC; pfam03591
335659008900	Branched-chain amino acid transport protein (AzlD); Region: AzlD; pfam05437
335659008901	Escherichia coli YaeB and related proteins; Region: UPF0066; cd09281
335659008902	homodimer interaction site [polypeptide binding]; other site
335659008903	cofactor binding site; other site
335659008904	HINT (histidine triad nucleotide-binding protein) subgroup: Members of this CD belong to the superfamily of histidine triad hydrolases that act on alpha-phosphate of ribonucleotides. This subgroup includes members from all three forms of cellular life; Region: HINT_subgroup; cd01277
335659008905	HIT family signature motif; other site
335659008906	catalytic residue [active]
335659008907	Protein of unknown function, DUF482; Region: DUF482; pfam04339
335659008908	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3146
335659008909	Glycerophosphodiester phosphodiesterase domain of uncharacterized bacterial glycerophosphodiester phosphodiesterases; Region: GDPD_like_3; cd08585
335659008910	Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584
335659008911	putative active site [active]
335659008912	catalytic site [active]
335659008913	putative metal binding site [ion binding]; other site
335659008914	This group of proteins belong to a large family of YjgF/YER057c/UK114-like proteins present in bacteria, archaea, and eukaryotes with no definitive function.  The conserved domain is similar in structure to chorismate mutase but there is no sequence...; Region: YjgF_YER057c_UK114_like_1; cd02199
335659008915	homotrimer interaction site [polypeptide binding]; other site
335659008916	putative active site [active]
335659008917	Domain of unknown function (DUF1849); Region: DUF1849; pfam08904
335659008918	YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448
335659008919	homotrimer interaction site [polypeptide binding]; other site
335659008920	putative active site [active]
335659008921	Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_31; cd04690
335659008922	nudix motif; other site
335659008923	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3602
335659008924	ACT domain; Region: ACT_3; pfam10000
335659008925	Family description; Region: ACT_7; pfam13840
335659008926	DNA polymerase IV; Provisional; Region: PRK02794
335659008927	DNA Polymerase IV/Kappa; Region: PolY_Pol_IV_kappa; cd03586
335659008928	active site
335659008929	DNA binding site [nucleotide binding]
335659008930	Protein of unknown function (DUF3572); Region: DUF3572; pfam12096
335659008931	FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784
335659008932	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
335659008933	active site
335659008934	phosphorylation site [posttranslational modification]
335659008935	intermolecular recognition site; other site
335659008936	dimerization interface [polypeptide binding]; other site
335659008937	response regulator PleD; Reviewed; Region: pleD; PRK09581
335659008938	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
335659008939	active site
335659008940	phosphorylation site [posttranslational modification]
335659008941	intermolecular recognition site; other site
335659008942	dimerization interface [polypeptide binding]; other site
335659008943	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
335659008944	active site
335659008945	phosphorylation site [posttranslational modification]
335659008946	intermolecular recognition site; other site
335659008947	dimerization interface [polypeptide binding]; other site
335659008948	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
335659008949	metal binding site [ion binding]; metal-binding site
335659008950	active site
335659008951	I-site; other site
335659008952	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
335659008953	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
335659008954	Type I periplasmic ligand-binding domain of uncharacterized ABC (ATPase Binding Cassette)-type active transport systems that are predicted to be involved in uptake of amino acids, peptides, or inorganic ions; Region: PBP1_ABC_ligand_binding_like_8; cd06343
335659008955	Periplasmic binding protein; Region: Peripla_BP_6; pfam13458
335659008956	putative ligand binding site [chemical binding]; other site
335659008957	Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680
335659008958	Beta-lactamase; Region: Beta-lactamase; pfam00144
335659008959	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
335659008960	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
335659008961	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
335659008962	putative substrate translocation pore; other site
335659008963	Major Facilitator Superfamily; Region: MFS_1; pfam07690
335659008964	arsenical pump-driving ATPase; Region: arsen_driv_ArsA; TIGR04291
335659008965	ArsA ATPase functionas as an efflux pump located on the inner membrane of the cell. This ATP-driven oxyanion pump catalyzes the extrusion of arsenite, antimonite and arsenate. Maintenance of a low intracellular concentration of oxyanion produces...; Region: ArsA; cd02035
335659008966	P loop; other site
335659008967	Nucleotide binding site [chemical binding]; other site
335659008968	DTAP/Switch II; other site
335659008969	Switch I; other site
335659008970	ArsA ATPase functionas as an efflux pump located on the inner membrane of the cell. This ATP-driven oxyanion pump catalyzes the extrusion of arsenite, antimonite and arsenate. Maintenance of a low intracellular concentration of oxyanion produces...; Region: ArsA; cd02035
335659008971	P loop; other site
335659008972	Nucleotide binding site [chemical binding]; other site
335659008973	DTAP/Switch II; other site
335659008974	Switch I; other site
335659008975	YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448
335659008976	homotrimer interaction site [polypeptide binding]; other site
335659008977	putative active site [active]
335659008978	Acyltransferase family; Region: Acyl_transf_3; pfam01757
335659008979	50S ribosomal protein L33; Validated; Region: rpmG; PRK00595
335659008980	nitrilotriacetate monoxygenase oxidizes nitrilotriacetate utilizing reduced flavin mononucleotide (FMNH2) and oxygen. The FMNH2 is provided by an NADH:flavin mononucleotide (FMN) oxidorductase that uses NADH to reduce FMN to FMNH2; Region: Nitrilotriacetate_monoxgenase; cd01095
335659008981	FMN-dependent oxidoreductase, nitrilotriacetate monooxygenase family; Region: FMN_nitrolo; TIGR03860
335659008982	active site
335659008983	non-prolyl cis peptide bond; other site
335659008984	Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cd02883
335659008985	nudix motif; other site
335659008986	hypothetical protein; Provisional; Region: PRK05978
335659008987	ribonuclease R; Region: RNase_R; TIGR02063
335659008988	RNB domain; Region: RNB; pfam00773
335659008989	S1_RNase_R: RNase R C-terminal S1 domain. RNase R is a processive 3' to 5' exoribonuclease, which is a homolog of RNase II. RNase R degrades RNA with secondary structure having a 3' overhang of at least 7 nucleotides. RNase R and PNPase...; Region: S1_RNase_R; cd04471
335659008990	RNA binding site [nucleotide binding]; other site
335659008991	DNA topoisomerase I subunit omega; Validated; Region: PRK07561
335659008992	TOPRIM_TopoIA_TopoI: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to Escherichia coli DNA topoisomerase I.   Type IA DNA topoisomerases remove (relax) negative supercoils in the...; Region: TOPRIM_TopoIA_TopoI; cd03363
335659008993	active site
335659008994	interdomain interaction site; other site
335659008995	putative metal-binding site [ion binding]; other site
335659008996	nucleotide binding site [chemical binding]; other site
335659008997	DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186
335659008998	domain I; other site
335659008999	DNA binding groove [nucleotide binding]
335659009000	phosphate binding site [ion binding]; other site
335659009001	domain II; other site
335659009002	domain III; other site
335659009003	nucleotide binding site [chemical binding]; other site
335659009004	catalytic site [active]
335659009005	domain IV; other site
335659009006	Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396
335659009007	Topoisomerase C-terminal repeat; Region: Toprim_C_rpt; pfam13368
335659009008	Topoisomerase C-terminal repeat; Region: Toprim_C_rpt; pfam13368
335659009009	Topoisomerase C-terminal repeat; Region: Toprim_C_rpt; pfam13368
335659009010	Predicted transcriptional regulators [Transcription]; Region: COG1733
335659009011	HxlR-like helix-turn-helix; Region: HxlR; pfam01638
335659009012	short chain dehydrogenase; Provisional; Region: PRK06500
335659009013	classical (c) SDRs; Region: SDR_c; cd05233
335659009014	NAD(P) binding site [chemical binding]; other site
335659009015	active site
335659009016	Flavodoxin-like fold; Region: Flavodoxin_2; cl00438
335659009017	NADPH-dependent FMN reductase; Region: FMN_red; pfam03358
335659009018	Predicted transcriptional regulators [Transcription]; Region: COG1733
335659009019	HxlR-like helix-turn-helix; Region: HxlR; pfam01638
335659009020	Predicted Rossmann fold nucleotide-binding protein involved in DNA uptake [DNA replication, recombination, and repair / Intracellular trafficking and secretion]; Region: Smf; COG0758
335659009021	DNA protecting protein DprA; Region: dprA; TIGR00732
335659009022	amidase; Provisional; Region: PRK07487
335659009023	Amidase; Region: Amidase; cl11426
335659009024	Patatins and Phospholipases; Region: Patatin_and_cPLA2; cl11396
335659009025	active site
335659009026	nucleophile elbow; other site
335659009027	putative glycerol-3-phosphate acyltransferase PlsY; Provisional; Region: PRK00220
335659009028	dihydroorotase; Validated; Region: PRK09059
335659009029	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
335659009030	Dihydroorotase (DHOase), subgroup IIa; DHOases catalyze the reversible interconversion of carbamoyl aspartate to dihydroorotate, a key reaction in pyrimidine biosynthesis. This subgroup also contains proteins that lack the active site, like unc-33, a C; Region: DHOase_IIa; cd01317
335659009031	active site
335659009032	aspartate carbamoyltransferase catalytic subunit; Provisional; Region: pyrB; PRK00856
335659009033	Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729
335659009034	Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185
335659009035	D-ala-D-ala dipeptidase; Region: Peptidase_M15; cl00813
335659009036	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
335659009037	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
335659009038	active site
335659009039	CAAX protease self-immunity; Region: Abi; pfam02517
335659009040	Predicted permeases [General function prediction only]; Region: COG0679
335659009041	Holliday junction resolvase-like protein; Reviewed; Region: PRK00109
335659009042	Transcriptional regulator [Transcription]; Region: LysR; COG0583
335659009043	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
335659009044	The C-terminal substrate binding domain of LysR-type transcriptional regulators, YofA and SoxR, contains the type 2 periplasmic binding fold; Region: PBP2_YofA_SoxR_like; cd08442
335659009045	putative dimerization interface [polypeptide binding]; other site
335659009046	Dioxygenases related to 2-nitropropane dioxygenase [General function prediction only]; Region: COG2070
335659009047	2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730
335659009048	FMN binding site [chemical binding]; other site
335659009049	substrate binding site [chemical binding]; other site
335659009050	putative catalytic residue [active]
335659009051	Dioxygenases related to 2-nitropropane dioxygenase [General function prediction only]; Region: COG2070
335659009052	2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730
335659009053	FMN binding site [chemical binding]; other site
335659009054	substrate binding site [chemical binding]; other site
335659009055	putative catalytic residue [active]
335659009056	aspartyl/glutamyl-tRNA amidotransferase subunit C; Reviewed; Region: gatC; PRK00034
335659009057	Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154
335659009058	aspartyl/glutamyl-tRNA amidotransferase subunit A; Reviewed; Region: gatA; PRK00012
335659009059	aspartyl/glutamyl-tRNA amidotransferase subunit B; Validated; Region: gatB; PRK05477
335659009060	GatB/GatE catalytic domain; Region: GatB_N; pfam02934
335659009061	GatB domain; Region: GatB_Yqey; smart00845
335659009062	Porin subfamily; Region: Porin_2; pfam02530
335659009063	Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741
335659009064	Lytic Transglycosylase (LT)  and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL).  LTs...; Region: LT_GEWL; cd00254
335659009065	N-acetyl-D-glucosamine binding site [chemical binding]; other site
335659009066	catalytic residue [active]
335659009067	Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329
335659009068	Dihydrodipicolinate synthase (DHDPS); Region: DHDPS; cd00950
335659009069	dimer interface [polypeptide binding]; other site
335659009070	active site
335659009071	catalytic residue [active]
335659009072	large-conductance mechanosensitive channel; Provisional; Region: mscL; PRK13952
335659009073	large-conductance mechanosensitive channel; Reviewed; Region: mscL; PRK00567
335659009074	Small protein B (SmpB) is a component of the trans-translation system in prokaryotes for releasing stalled ribosome from damaged messenger RNAs; Region: SmpB; cd09294
335659009075	SmpB-tmRNA interface; other site
335659009076	Peroxiredoxin (PRX) family, Bacterioferritin comigratory protein (BCP) subfamily; composed of thioredoxin-dependent thiol peroxidases, widely expressed in pathogenic bacteria, that protect cells against toxicity from reactive oxygen species by reducing...; Region: PRX_BCP; cd03017
335659009077	catalytic triad [active]
335659009078	Family-5 Uracil-DNA glycosylases (UDG), found in thermophilic organisms; Region: UDG_F5_TTUDGB_like; cd10031
335659009079	Fe-S cluster binding site [ion binding]; other site
335659009080	DNA binding site [nucleotide binding]
335659009081	active site
335659009082	Uncharacterized conserved protein [Function unknown]; Region: COG1432
335659009083	LabA_like proteins; Region: LabA; cd10911
335659009084	putative metal binding site [ion binding]; other site
335659009085	DNA-directed RNA polymerase subunit omega; Reviewed; Region: rpoZ; PRK00392
335659009086	Guanosine polyphosphate pyrophosphohydrolases/synthetases [Signal transduction mechanisms / Transcription]; Region: SpoT; COG0317
335659009087	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
335659009088	Zn2+ binding site [ion binding]; other site
335659009089	Mg2+ binding site [ion binding]; other site
335659009090	Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399
335659009091	synthetase active site [active]
335659009092	NTP binding site [chemical binding]; other site
335659009093	metal binding site [ion binding]; metal-binding site
335659009094	TGS_RelA_SpoT: The RelA (SpoT) protein, also referred to as ppGpp hydrolase/synthetase, is a ribosome-associated protein that is activated during amino acid starvation and thought to mediate the stringent response. RelA contains a TGS domain, named after...; Region: TGS_RelA_SpoT; cd01668
335659009095	ACT  domain found C-terminal of the RelA/SpoT domains; Region: ACT_RelA-SpoT; cd04876
335659009096	Pyridoxine 5'-phosphate (PNP) synthase domain; pyridoxal 5'-phosphate is the active form of vitamin B6 that acts as an essential, ubiquitous coenzyme in amino acid metabolism. In bacteria, formation of pyridoxine 5'-phosphate is a step in...; Region: PNPsynthase; cd00003
335659009097	active site
335659009098	hydrophilic channel; other site
335659009099	dimerization interface [polypeptide binding]; other site
335659009100	catalytic residues [active]
335659009101	active site lid [active]
335659009102	4'-phosphopantetheinyl transferase; Provisional; Region: acpS; PRK00070
335659009103	signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227
335659009104	The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530
335659009105	Catalytic site [active]
335659009106	The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530
335659009107	ribonuclease III, bacterial; Region: RNaseIII; TIGR02191
335659009108	RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in...; Region: RIBOc; cd00593
335659009109	dimerization interface [polypeptide binding]; other site
335659009110	active site
335659009111	metal binding site [ion binding]; metal-binding site
335659009112	Double-stranded RNA binding motif. Binding is not sequence specific but is highly specific for double stranded RNA. Found in a variety of proteins including dsRNA dependent protein kinase PKR, RNA helicases, Drosophila staufen protein, E. coli RNase III; Region: DSRM; cd00048
335659009113	dsRNA binding site [nucleotide binding]; other site
335659009114	GTPase Era; Reviewed; Region: era; PRK00089
335659009115	E. coli Ras-like protein (Era) is a multifunctional GTPase; Region: Era; cd04163
335659009116	G1 box; other site
335659009117	GTP/Mg2+ binding site [chemical binding]; other site
335659009118	Switch I region; other site
335659009119	G2 box; other site
335659009120	Switch II region; other site
335659009121	G3 box; other site
335659009122	G4 box; other site
335659009123	G5 box; other site
335659009124	KH domain; Region: KH_2; pfam07650
335659009125	DNA repair protein RecO; Reviewed; Region: recO; PRK00085
335659009126	Recombination protein O N terminal; Region: RecO_N; pfam11967
335659009127	Recombination protein O C terminal; Region: RecO_C; pfam02565
335659009128	DNA topoisomerase IV subunit A; Validated; Region: PRK05561
335659009129	DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187
335659009130	CAP-like domain; other site
335659009131	active site
335659009132	primary dimer interface [polypeptide binding]; other site
335659009133	ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747
335659009134	The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_16; cd08502
335659009135	Choline dehydrogenase and related flavoproteins [Amino acid transport and metabolism]; Region: BetA; COG2303
335659009136	GMC oxidoreductase; Region: GMC_oxred_C; pfam05199
335659009137	Zn-dependent dipeptidase, microsomal dipeptidase homolog [Amino acid transport and metabolism]; Region: COG2355
335659009138	renal dipeptidase (rDP), best studied in mammals and also called membrane or microsomal dipeptidase, is a membrane-bound glycoprotein hydrolyzing dipeptides and is involved in hydrolytic metabolism of penem and carbapenem beta-lactam antibiotics; Region: rDP_like; cd01301
335659009139	active site
335659009140	dimer interface [polypeptide binding]; other site
335659009141	Chromate transport protein ChrA [Inorganic ion transport and metabolism]; Region: ChrA; COG2059
335659009142	Chromate transporter; Region: Chromate_transp; pfam02417
335659009143	GlpE sulfurtransferase (ST) and homologs are members of the Rhodanese Homology Domain superfamily. Unlike other rhodanese sulfurtransferases, GlpE is a single domain protein but indications are that it functions as a dimer. The active site contains a...; Region: GlpE_ST; cd01444
335659009144	active site residue [active]
335659009145	Chromate resistance exported protein; Region: Chrome_Resist; pfam09828
335659009146	Co/Zn/Cd efflux system component [Inorganic ion transport and metabolism]; Region: CzcD; COG1230
335659009147	Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053
335659009148	Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849
335659009149	Major Facilitator Superfamily; Region: MFS_1; pfam07690
335659009150	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
335659009151	putative substrate translocation pore; other site
335659009152	Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114
335659009153	cyclase homology domain; Region: CHD; cd07302
335659009154	nucleotidyl binding site; other site
335659009155	metal binding site [ion binding]; metal-binding site
335659009156	dimer interface [polypeptide binding]; other site
335659009157	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
335659009158	manganese transport protein MntH; Reviewed; Region: PRK00701
335659009159	Natural resistance-associated macrophage protein; Region: Nramp; pfam01566
335659009160	arginyl-tRNA-protein transferase; Provisional; Region: PRK01305
335659009161	Arginine-tRNA-protein transferase, N terminus; Region: ATE_N; pfam04376
335659009162	Arginine-tRNA-protein transferase, C terminus; Region: ATE_C; pfam04377
335659009163	RDD family; Region: RDD; pfam06271
335659009164	Porphobilinogen synthase (PBGS), which is also called delta-aminolevulinic acid dehydratase (ALAD), catalyzes the condensation of two 5-aminolevulinic acid (ALA) molecules to form the pyrrole porphobilinogen (PBG), which is the second step in the...; Region: ALAD_PBGS_aspartate_rich; cd04823
335659009165	dimer interface [polypeptide binding]; other site
335659009166	allosteric magnesium binding site [ion binding]; other site
335659009167	active site
335659009168	aspartate-rich active site metal binding site; other site
335659009169	Schiff base residues; other site
335659009170	Transcriptional regulators [Transcription]; Region: MarR; COG1846
335659009171	serine hydroxymethyltransferase; Reviewed; Region: glyA; PRK00011
335659009172	Serine-glycine hydroxymethyltransferase (SHMT). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). SHMT carries out interconversion of serine and glycine; it catalyzes the transfer of hydroxymethyl...; Region: SHMT; cd00378
335659009173	dimer interface [polypeptide binding]; other site
335659009174	active site
335659009175	glycine-pyridoxal phosphate binding site [chemical binding]; other site
335659009176	folate binding site [chemical binding]; other site
335659009177	transcriptional regulator NrdR; Validated; Region: nrdR; PRK00464
335659009178	ATP cone domain; Region: ATP-cone; pfam03477
335659009179	riboflavin biosynthesis protein RibD; Region: eubact_ribD; TIGR00326
335659009180	Riboflavin-specific deaminase. Riboflavin biosynthesis protein RibD (Diaminohydroxyphosphoribosylaminopyrimidine deaminase) catalyzes the deamination of 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate, which is an intermediate step in the...; Region: Riboflavin_deaminase-reductase; cd01284
335659009181	catalytic motif [active]
335659009182	Zn binding site [ion binding]; other site
335659009183	RibD C-terminal domain; Region: RibD_C; cl17279
335659009184	riboflavin synthase subunit alpha; Provisional; Region: PRK09289
335659009185	Lumazine binding domain; Region: Lum_binding; pfam00677
335659009186	Lumazine binding domain; Region: Lum_binding; pfam00677
335659009187	lumazine synthase (6,7-dimethyl-8-ribityllumazine synthase, LS), catalyzes the penultimate step in the biosynthesis of riboflavin (vitamin B2); type-I; Region: Lumazine_synthase-I; cd09209
335659009188	homopentamer interface [polypeptide binding]; other site
335659009189	active site
335659009190	transcription antitermination protein NusB; Reviewed; Region: nusB; PRK00202
335659009191	putative RNA binding site [nucleotide binding]; other site
335659009192	thiamine monophosphate kinase; Provisional; Region: PRK05731
335659009193	ThiL (Thiamine-monophosphate kinase) plays a dual role in de novo biosynthesis and in salvage of exogenous thiamine. Thiamine salvage occurs in two steps, with thiamine kinase catalyzing the formation of thiamine phosphate, and ThiL catalyzing the...; Region: ThiL; cd02194
335659009194	ATP binding site [chemical binding]; other site
335659009195	dimerization interface [polypeptide binding]; other site
335659009196	H(+) -translocating inorganic pyrophosphatase; Region: PLN02255; cl11452
335659009197	membrane-bound proton-translocating pyrophosphatase; Validated; Region: hppA; PRK00733
335659009198	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3181
335659009199	Outer membrane lipoprotein OmlA (small protein A) [Cell envelope biogenesis, outer membrane]; Region: OlmA; COG2913
335659009200	SmpA / OmlA family; Region: SmpA_OmlA; pfam04355
335659009201	Ubiquinol-cytochrome C chaperone; Region: Ubiq_cyt_C_chap; pfam03981
335659009202	Uncharacterized ACR, COG1399; Region: DUF177; pfam02620
335659009203	putative phosphate acyltransferase; Provisional; Region: PRK05331
335659009204	3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK09352
335659009205	Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830
335659009206	dimer interface [polypeptide binding]; other site
335659009207	active site
335659009208	CoA binding pocket [chemical binding]; other site
335659009209	Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591
335659009210	IHF dimer interface [polypeptide binding]; other site
335659009211	IHF - DNA interface [nucleotide binding]; other site
335659009212	Helix-Turn-Helix DNA binding domain of putative MlrA-like transcription regulators; Region: HTH_MlrA-like_sg2; cd04765
335659009213	MerR HTH family regulatory protein; Region: MerR_1; pfam13411
335659009214	DNA binding residues [nucleotide binding]
335659009215	alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859
335659009216	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
335659009217	Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329
335659009218	Dihydrodipicolinate synthase family; Region: DHDPS-like; cd00408
335659009219	inhibitor site; inhibition site
335659009220	active site
335659009221	dimer interface [polypeptide binding]; other site
335659009222	catalytic residue [active]
335659009223	classical (c) SDRs; Region: SDR_c; cd05233
335659009224	short chain dehydrogenase; Provisional; Region: PRK05650
335659009225	NAD(P) binding site [chemical binding]; other site
335659009226	active site
335659009227	fermentation/respiration switch protein; Reviewed; Region: frsA; PRK05077
335659009228	Transcriptional regulators [Transcription]; Region: MarR; COG1846
335659009229	MarR family; Region: MarR_2; cl17246
335659009230	Porin subfamily; Region: Porin_2; pfam02530
335659009231	GcrA cell cycle regulator; Region: GcrA; pfam07750
335659009232	Predicted acetamidase/formamidase [Energy production and conversion]; Region: COG2421
335659009233	Uncharacterized conserved protein [Function unknown]; Region: COG1434
335659009234	YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259
335659009235	putative active site [active]
335659009236	Uncharacterized ArCR, COG2043; Region: DUF169; pfam02596
335659009237	Uncharacterized conserved protein [Function unknown]; Region: COG3268
335659009238	hypothetical protein; Provisional; Region: PRK06753
335659009239	ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314
335659009240	helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347
335659009241	MarR family; Region: MarR; pfam01047
335659009242	Undecaprenyl-phosphate glucose phosphotransferase; Region: WcaJ_sugtrans; TIGR03023
335659009243	prephenate dehydrogenase; Validated; Region: PRK08507
335659009244	Sugar transferases involved in lipopolysaccharide synthesis [Cell envelope biogenesis, outer membrane]; Region: WcaJ; COG2148
335659009245	This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801
335659009246	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
335659009247	Uncharacterized protein involved in exopolysaccharide biosynthesis [Cell envelope biogenesis, outer membrane]; Region: GumC; COG3206
335659009248	Chain length determinant protein; Region: Wzz; cl15801
335659009249	AAA domain; Region: AAA_31; pfam13614
335659009250	Protein involved in cellulose biosynthesis (CelD) [Cell envelope biogenesis, outer membrane]; Region: COG5653
335659009251	Acetyltransferase (GNAT) domain; Region: Acetyltransf_6; pfam13480
335659009252	Putative catalytic NodB homology domain of Mesorhizobium loti Mlr8448 protein and its bacterial homologs; Region: CE4_Mlr8448_like_5s; cd10968
335659009253	putative active site [active]
335659009254	putative metal binding site [ion binding]; other site
335659009255	Protein of unknown function (DUF2842); Region: DUF2842; pfam11003
335659009256	Uncharacterized protein required for cytochrome oxidase assembly [Posttranslational modification, protein turnover, chaperones]; Region: CtaA; COG1612
335659009257	Cytochrome oxidase assembly protein; Region: COX15-CtaA; cl15852
335659009258	O-acetylhomoserine aminocarboxypropyltransferase; Validated; Region: PRK05994
335659009259	CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614
335659009260	homodimer interface [polypeptide binding]; other site
335659009261	substrate-cofactor binding pocket; other site
335659009262	pyridoxal 5'-phosphate binding site [chemical binding]; other site
335659009263	catalytic residue [active]
335659009264	Predicted CoA-binding protein [General function prediction only]; Region: COG1832
335659009265	enoyl-CoA hydratase; Validated; Region: PRK08139
335659009266	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
335659009267	substrate binding site [chemical binding]; other site
335659009268	oxyanion hole (OAH) forming residues; other site
335659009269	trimer interface [polypeptide binding]; other site
335659009270	PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria.  Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443
335659009271	CoenzymeA binding site [chemical binding]; other site
335659009272	subunit interaction site [polypeptide binding]; other site
335659009273	PHB binding site; other site
335659009274	Ribosomal protein L13.  Protein L13, a large ribosomal subunit protein, is one of five proteins required for an early folding intermediate of 23S rRNA in the assembly of the large subunit. L13 is situated on the bottom of the large subunit, near the...; Region: Ribosomal_L13; cd00392
335659009275	23S rRNA interface [nucleotide binding]; other site
335659009276	L3 interface [polypeptide binding]; other site
335659009277	30S ribosomal protein S9; Reviewed; Region: rpsI; PRK00132
335659009278	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
335659009279	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
335659009280	metal binding site [ion binding]; metal-binding site
335659009281	active site
335659009282	I-site; other site
335659009283	enoyl-CoA hydratase; Provisional; Region: PRK08138
335659009284	Antibiotic biosynthesis monooxygenase; Region: ABM; pfam03992
335659009285	Domain of unknown function DUF20; Region: UPF0118; pfam01594
335659009286	Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628
335659009287	Peptidase C26; Region: Peptidase_C26; pfam07722
335659009288	Subgroup of proteins having the Type 1 glutamine amidotransferase (GATase1) domain; Region: GATase1_2; cd01745
335659009289	catalytic triad [active]
335659009290	AraC transcriptional regulators having a Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GATase1_AraC_2; cd03138
335659009291	Transcriptional regulator containing an amidase domain and an AraC-type DNA-binding HTH domain [Transcription]; Region: COG4977
335659009292	conserved cys residue [active]
335659009293	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
335659009294	4-Oxalocrotonate Tautomerase:  Catalyzes the isomerization of unsaturated ketones. The structure is a homohexamer that is arranged as a trimer of dimers. The hexamer contains six active sites, each formed by residues from three monomers, two from one...; Region: 4Oxalocrotonate_Tautomerase; cl00235
335659009295	active site 1 [active]
335659009296	dimer interface [polypeptide binding]; other site
335659009297	hexamer interface [polypeptide binding]; other site
335659009298	active site 2 [active]
335659009299	glutamine synthetase; Provisional; Region: glnA; PRK09469
335659009300	Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951
335659009301	Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120
335659009302	Nitrogen regulatory protein PII [Amino acid transport and metabolism]; Region: GlnK; COG0347
335659009303	Nitrogen regulatory protein P-II; Region: P-II; smart00938
335659009304	Uncharacterized conserved protein [Function unknown]; Region: COG0062
335659009305	B.subtilis YXKO protein of unknown function and related proteins. Based on the conservation of the ATP binding site, the substrate binding site and the Mg2+binding site and structural homology this group is a member of the ribokinase-like superfamily; Region: YXKO-related; cd01171
335659009306	putative substrate binding site [chemical binding]; other site
335659009307	putative ATP binding site [chemical binding]; other site
335659009308	Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673
335659009309	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
335659009310	Coenzyme A binding pocket [chemical binding]; other site
335659009311	Putative multicopper oxidases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: SufI; COG2132
335659009312	Multicopper oxidase; Region: Cu-oxidase; pfam00394
335659009313	Multicopper oxidase; Region: Cu-oxidase_2; pfam07731
335659009314	trigger factor; Provisional; Region: tig; PRK01490
335659009315	FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254
335659009316	Bacterial trigger factor protein (TF) C-terminus; Region: Trigger_C; pfam05698
335659009317	Protease subunit of ATP-dependent Clp proteases [Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: ClpP; COG0740
335659009318	Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017
335659009319	oligomer interface [polypeptide binding]; other site
335659009320	active site residues [active]
335659009321	ATP-dependent protease ATP-binding subunit ClpX; Provisional; Region: clpX; PRK05342
335659009322	ClpX C4-type zinc finger; Region: zf-C4_ClpX; pfam06689
335659009323	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
335659009324	Walker A motif; other site
335659009325	ATP binding site [chemical binding]; other site
335659009326	Walker B motif; other site
335659009327	C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086
335659009328	ATP-dependent Lon protease, bacterial type [Posttranslational modification, protein turnover, chaperones]; Region: Lon; COG0466
335659009329	Found in ATP-dependent protease La (LON); Region: LON; smart00464
335659009330	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
335659009331	Walker A motif; other site
335659009332	ATP binding site [chemical binding]; other site
335659009333	Walker B motif; other site
335659009334	arginine finger; other site
335659009335	Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362
335659009336	potential frameshift: common BLAST hit: gi|378828535|ref|YP_005191267.1| putative glutathione-dependent formaldehyde-activating enzyme
335659009337	Glutathione-dependent formaldehyde-activating enzyme; Region: GFA; cl01553
335659009338	Glutathione-dependent formaldehyde-activating enzyme; Region: GFA; cl01553
335659009339	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173
335659009340	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
335659009341	S-adenosylmethionine binding site [chemical binding]; other site
335659009342	Co/Zn/Cd efflux system component [Inorganic ion transport and metabolism]; Region: CzcD; COG1230
335659009343	heavy metal efflux pump, CzcA family; Region: 2A0601; TIGR00914
335659009344	Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404
335659009345	lipoyl-biotinyl attachment site [posttranslational modification]; other site
335659009346	HlyD family secretion protein; Region: HlyD_3; pfam13437
335659009347	Outer membrane efflux protein; Region: OEP; pfam02321
335659009348	Outer membrane efflux protein; Region: OEP; pfam02321
335659009349	DNA-binding transcriptional activator FeaR; Provisional; Region: PRK09685
335659009350	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
335659009351	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
335659009352	Acyl-CoA dehydrogenase, N-terminal domain; Region: Acyl-CoA_dh_N; pfam02771
335659009353	Acyl-CoA dehydrogenase; Region: ACAD; cd00567
335659009354	active site
335659009355	M20 Peptidase T specifically cleaves tripeptides; Region: M20_peptT; cd03892
335659009356	peptidase T; Region: peptidase-T; TIGR01882
335659009357	metal binding site [ion binding]; metal-binding site
335659009358	dimer interface [polypeptide binding]; other site
335659009359	Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591
335659009360	IHF dimer interface [polypeptide binding]; other site
335659009361	IHF - DNA interface [nucleotide binding]; other site
335659009362	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
335659009363	Major Facilitator Superfamily; Region: MFS_1; pfam07690
335659009364	putative substrate translocation pore; other site
335659009365	Rieske non-heme iron oxygenase (RO) family, Phthalate 4,5-dioxygenase (PhDO)-like subfamily, N-terminal Rieske domain of the oxygenase alpha subunit; composed of the oxygenase alpha subunits of PhDO and similar proteins including 3-chlorobenzoate 3; Region: Rieske_RO_Alpha_PhDO_like; cd03479
335659009366	Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638
335659009367	C-terminal catalytic domain of the oxygenase alpha subunit of dicamba O-demethylase and related aromatic ring hydroxylating dioxygenases; Region: RHO_alpha_C_DMO-like; cd08878
335659009368	alpha subunit interface [polypeptide binding]; other site
335659009369	active site
335659009370	substrate binding site [chemical binding]; other site
335659009371	Fe binding site [ion binding]; other site
335659009372	helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347
335659009373	MarR family; Region: MarR_2; pfam12802
335659009374	ferrichrome receptor precursor protein; Provisional; Region: PRK14050
335659009375	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
335659009376	N-terminal plug; other site
335659009377	ligand-binding site [chemical binding]; other site
335659009378	NADH:ubiquinone oxidoreductase subunit A; Validated; Region: PRK06602
335659009379	NADH dehydrogenase subunit B; Validated; Region: PRK06411
335659009380	NADH dehydrogenase subunit C; Provisional; Region: PRK06074
335659009381	NADH (or F420H2) dehydrogenase, subunit C; Region: NuoC_fam; TIGR01961
335659009382	NADH:ubiquinone oxidoreductase 49 kD subunit 7 [Energy production and conversion]; Region: NuoD; COG0649
335659009383	NADH dehydrogenase subunit D; Validated; Region: PRK06075
335659009384	methyltransferase, FkbM family; Region: fkbM_fam; TIGR01444
335659009385	NADH dehydrogenase subunit E; Validated; Region: PRK07539
335659009386	TRX-like [2Fe-2S] Ferredoxin (Fd) family, NADH:ubiquinone oxidoreductase (Nuo) subunit E subfamily; Nuo, also called respiratory chain Complex 1, is the entry point for electrons into the respiratory chains of bacteria and the mitochondria of eukaryotes; Region: TRX_Fd_NuoE; cd03064
335659009387	putative dimer interface [polypeptide binding]; other site
335659009388	[2Fe-2S] cluster binding site [ion binding]; other site
335659009389	NADH dehydrogenase I subunit F; Provisional; Region: PRK13596
335659009390	SLBB domain; Region: SLBB; pfam10531
335659009391	NADH-ubiquinone oxidoreductase-F iron-sulfur binding region; Region: NADH_4Fe-4S; smart00928
335659009392	NADH dehydrogenase subunit G; Validated; Region: PRK09130
335659009393	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
335659009394	catalytic loop [active]
335659009395	iron binding site [ion binding]; other site
335659009396	NADH-ubiquinone oxidoreductase-G iron-sulfur binding region; Region: NADH-G_4Fe-4S_3; pfam10588
335659009397	MopB_Res_Cmplx1_Nad11: The second domain of the Nad11/75-kDa subunit of the NADH-quinone oxidoreductase/respiratory complex I/NADH dehydrogenase-1(NDH-1) of eukaryotes and the Nqo3/G subunit of alphaproteobacteria NDH-1. The NADH-quinone oxidoreductase...; Region: MopB_Res-Cmplx1_Nad11; cd02773
335659009398	Domain of unknown function (DUF1982); Region: DUF1982; pfam09326
335659009399	NADH:ubiquinone oxidoreductase subunit H; Provisional; Region: PRK06076
335659009400	Formate hydrogenlyase subunit 4 [Energy production and conversion]; Region: HyfC; COG0650
335659009401	NADH dehydrogenase subunit I; Provisional; Region: PRK05888
335659009402	4Fe-4S binding domain; Region: Fer4; pfam00037
335659009403	4Fe-4S binding domain; Region: Fer4; pfam00037
335659009404	NADH:ubiquinone oxidoreductase subunit J; Provisional; Region: PRK06638
335659009405	NADH dehydrogenase subunit 6; Provisional; Region: ND6; MTH00213
335659009406	NADH:ubiquinone oxidoreductase subunit K; Validated; Region: PRK05715
335659009407	NADH:ubiquinone oxidoreductase subunit L; Reviewed; Region: PRK06590
335659009408	NADH-Ubiquinone oxidoreductase (complex I), chain 5 N-terminus; Region: Oxidored_q1_N; pfam00662
335659009409	NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361
335659009410	NADH:ubiquinone oxidoreductase subunit M; Reviewed; Region: PRK05846
335659009411	NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361
335659009412	NADH:ubiquinone oxidoreductase subunit N; Provisional; Region: PRK05777
335659009413	NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361
335659009414	Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; cl14057
335659009415	Biotin-(acetyl-CoA carboxylase) ligase [Coenzyme metabolism]; Region: BirA; COG0340
335659009416	Biotin protein ligase C terminal domain; Region: BPL_C; pfam02237
335659009417	mRNA degradation ribonucleases J1/J2 (metallo-beta-lactamase superfamily) [Translation, ribosomal structure and biogenesis; Replication, recombination and repair]; Region: COG0595
335659009418	Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849
335659009419	RNA-metabolising metallo-beta-lactamase; Region: RMMBL; pfam07521
335659009420	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
335659009421	Methylmalonyl-CoA epimerase (MMCE); Region: MMCE; cd07249
335659009422	dimer interface [polypeptide binding]; other site
335659009423	substrate binding site [chemical binding]; other site
335659009424	metal binding site [ion binding]; metal-binding site
335659009425	Protein of unknown function (DUF1467); Region: DUF1467; pfam07330
335659009426	methylthioribose kinase; Reviewed; Region: mtnK; PRK09550
335659009427	Phosphotransferase enzyme family; Region: APH; pfam01636
335659009428	Alcohol dehydrogenase, class IV [Energy production and conversion]; Region: EutG; COG1454
335659009429	Iron-containing alcohol dehydrogenases-like, involved in the linear alkylbenzenesulfonate (LAS) degradation pathway; Region: Fe-ADH7; cd08192
335659009430	putative active site [active]
335659009431	metal binding site [ion binding]; metal-binding site
335659009432	Transcriptional regulators [Transcription]; Region: FadR; COG2186
335659009433	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
335659009434	DNA-binding site [nucleotide binding]; DNA binding site
335659009435	This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895
335659009436	ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600
335659009437	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
335659009438	dimer interface [polypeptide binding]; other site
335659009439	conserved gate region; other site
335659009440	putative PBP binding loops; other site
335659009441	ABC-ATPase subunit interface; other site
335659009442	ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600
335659009443	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
335659009444	dimer interface [polypeptide binding]; other site
335659009445	conserved gate region; other site
335659009446	putative PBP binding loops; other site
335659009447	ABC-ATPase subunit interface; other site
335659009448	ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116
335659009449	ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293
335659009450	Walker A/P-loop; other site
335659009451	ATP binding site [chemical binding]; other site
335659009452	Q-loop/lid; other site
335659009453	ABC transporter signature motif; other site
335659009454	Walker B; other site
335659009455	D-loop; other site
335659009456	H-loop/switch region; other site
335659009457	NMT1-like family; Region: NMT1_2; pfam13379
335659009458	ABC transporter, substrate-binding protein, aliphatic sulfonates family; Region: SsuA_fam; TIGR01728
335659009459	DNA-binding transcriptional activator GcvA; Provisional; Region: PRK11139
335659009460	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
335659009461	YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448
335659009462	homotrimer interaction site [polypeptide binding]; other site
335659009463	putative active site [active]
335659009464	L-2-amino-thiazoline-4-carboxylic acid hydrolase; Region: ATC_hydrolase; pfam14196
335659009465	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
335659009466	Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579
335659009467	TM-ABC transporter signature motif; other site
335659009468	ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129
335659009469	First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216
335659009470	Walker A/P-loop; other site
335659009471	ATP binding site [chemical binding]; other site
335659009472	Q-loop/lid; other site
335659009473	ABC transporter signature motif; other site
335659009474	Walker B; other site
335659009475	D-loop; other site
335659009476	H-loop/switch region; other site
335659009477	Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215
335659009478	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: RbsB; COG1879
335659009479	Periplasmic sugar-binding domain of uncharacterized ABC-type transport systems; Region: PBP1_ABC_sugar_binding_like_5; cd06313
335659009480	putative ligand binding site [chemical binding]; other site
335659009481	Globins are heme proteins, which bind and transport oxygen. This family summarizes a diverse set of homologous protein domains, including: (1) tetrameric vertebrate hemoglobins, which are the major protein component of erythrocytes and transport oxygen...; Region: globin; cd01040
335659009482	heme-binding site [chemical binding]; other site
335659009483	Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629
335659009484	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
335659009485	N-terminal plug; other site
335659009486	ligand-binding site [chemical binding]; other site
335659009487	BNR repeat-like domain; Region: BNR_2; pfam13088
335659009488	TlpA-like family; composed of  TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966
335659009489	Thioredoxin-like; Region: Thioredoxin_8; pfam13905
335659009490	catalytic residues [active]
335659009491	Protein of unknown function (DUF461); Region: DUF461; pfam04314
335659009492	Reeler-like domain of YcnI and similar proteins; Region: YcnI_like; cd08545
335659009493	CopC domain; Region: CopC; pfam04234
335659009494	Putative copper export protein [Inorganic ion transport and metabolism]; Region: PcoD; COG1276
335659009495	prolyl-tRNA synthetase; Provisional; Region: PRK12325
335659009496	Prolyl-tRNA synthetase (ProRS) class II core catalytic domain. ProRS is a homodimer. It is responsible for the attachment of proline to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ProRS_core_prok; cd00779
335659009497	dimer interface [polypeptide binding]; other site
335659009498	motif 1; other site
335659009499	active site
335659009500	motif 2; other site
335659009501	Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA.   PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268
335659009502	active site
335659009503	motif 3; other site
335659009504	ProRS Prolyl-anticodon binding domain, short version found predominantly in bacteria. ProRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding; Region: ProRS_anticodon_short; cd00861
335659009505	anticodon binding site; other site
335659009506	lipoprotein releasing system, transmembrane protein, LolC/E family; Region: lolCE; TIGR02212
335659009507	MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
335659009508	FtsX-like permease family; Region: FtsX; pfam02687
335659009509	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
335659009510	ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255
335659009511	Walker A/P-loop; other site
335659009512	ATP binding site [chemical binding]; other site
335659009513	Q-loop/lid; other site
335659009514	ABC transporter signature motif; other site
335659009515	Walker B; other site
335659009516	D-loop; other site
335659009517	H-loop/switch region; other site
335659009518	NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604
335659009519	Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912
335659009520	NAD(P) binding site [chemical binding]; other site
335659009521	Helix-turn-helix domain; Region: HTH_31; pfam13560
335659009522	sequence-specific DNA binding site [nucleotide binding]; other site
335659009523	salt bridge; other site
335659009524	Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670
335659009525	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182
335659009526	Opacity protein and related surface antigens [Cell envelope biogenesis, outer membrane]; Region: COG3637
335659009527	Cyclopropane fatty acid synthase and related methyltransferases [Cell envelope biogenesis, outer membrane]; Region: Cfa; COG2230
335659009528	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173
335659009529	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
335659009530	S-adenosylmethionine binding site [chemical binding]; other site
335659009531	Protein of unknown function (DUF1365); Region: DUF1365; pfam07103
335659009532	Predicted NAD/FAD-binding protein [General function prediction only]; Region: COG2907
335659009533	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
335659009534	Protein of unknown function (DUF1295); Region: DUF1295; cl17837
335659009535	Cyclopropane fatty acid synthase and related methyltransferases [Cell envelope biogenesis, outer membrane]; Region: Cfa; COG2230
335659009536	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
335659009537	S-adenosylmethionine binding site [chemical binding]; other site
335659009538	Predicted membrane protein (DUF2177); Region: DUF2177; pfam09945
335659009539	Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814
335659009540	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
335659009541	putative substrate translocation pore; other site
335659009542	Protein of unknown function (DUF3551); Region: DUF3551; pfam12071
335659009543	Protein of unknown function (DUF3551); Region: DUF3551; pfam12071
335659009544	Opacity protein and related surface antigens [Cell envelope biogenesis, outer membrane]; Region: COG3637
335659009545	DNA polymerase III subunit alpha; Validated; Region: dnaE; PRK05673
335659009546	Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III DnaE1; Region: PHP_PolIIIA_DnaE1; cd07433
335659009547	putative active site [active]
335659009548	putative PHP Thumb interface [polypeptide binding]; other site
335659009549	DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485
335659009550	generic binding surface I; other site
335659009551	generic binding surface II; other site
335659009552	Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA_cladeC; cd03378
335659009553	active site clefts [active]
335659009554	zinc binding site [ion binding]; other site
335659009555	dimer interface [polypeptide binding]; other site
335659009556	Uncharacterized protein containing caspase domain [General function prediction only]; Region: COG4249
335659009557	Caspase domain; Region: Peptidase_C14; pfam00656
335659009558	30S ribosomal protein S2/unknown domain fusion protein; Provisional; Region: rpsB; PRK12311
335659009559	Ribosomal protein S2 (RPS2), involved in formation of the translation initiation complex, where it might contact the messenger RNA and several components of the ribosome. It has been shown that in Escherichia coli RPS2 is essential for the binding of...; Region: RPS2; cd01425
335659009560	rRNA interaction site [nucleotide binding]; other site
335659009561	S8 interaction site; other site
335659009562	putative laminin-1 binding site; other site
335659009563	Uncharacterized conserved protein [Function unknown]; Region: COG3743
335659009564	elongation factor Ts; Provisional; Region: tsf; PRK09377
335659009565	UBA/TS-N domain; Region: UBA; pfam00627
335659009566	Elongation factor TS; Region: EF_TS; pfam00889
335659009567	Elongation factor TS; Region: EF_TS; pfam00889
335659009568	UMP kinase (UMPK)-Ec, the microbial/chloroplast uridine monophosphate kinase (uridylate kinase) enzyme that catalyzes UMP phosphorylation and plays a key role in pyrimidine nucleotide biosynthesis; regulation of this process is via feed-back control and...; Region: AAK_UMPK-PyrH-Ec; cd04254
335659009569	putative nucleotide binding site [chemical binding]; other site
335659009570	uridine monophosphate binding site [chemical binding]; other site
335659009571	homohexameric interface [polypeptide binding]; other site
335659009572	ribosome recycling factor; Reviewed; Region: frr; PRK00083
335659009573	Ribosome recycling factor (RRF). Ribosome recycling factor dissociates the posttermination complex, composed of the ribosome, deacylated tRNA, and mRNA, after termination of translation.  Thus ribosomes are "recycled" and ready for another...; Region: RRF; cd00520
335659009574	hinge region; other site
335659009575	undecaprenyl pyrophosphate synthase; Provisional; Region: PRK14834
335659009576	Cis (Z)-Isoprenyl Diphosphate Synthases (cis-IPPS); homodimers which catalyze the successive 1'-4 condensation of the isopentenyl diphosphate (IPP) molecule to trans,trans-farnesyl diphosphate (FPP) or to cis,trans-FPP to form long-chain polyprenyl...; Region: CIS_IPPS; cl00230
335659009577	catalytic residue [active]
335659009578	putative FPP diphosphate  binding site; other site
335659009579	putative FPP binding hydrophobic cleft; other site
335659009580	dimer interface [polypeptide binding]; other site
335659009581	putative IPP diphosphate binding site; other site
335659009582	Cytidylyltransferase family; Region: CTP_transf_1; pfam01148
335659009583	CDP-diglyceride synthetase [Lipid metabolism]; Region: CdsA; COG0575
335659009584	1-deoxy-D-xylulose 5-phosphate reductoisomerase; Provisional; Region: PRK05447
335659009585	1-deoxy-D-xylulose 5-phosphate reductoisomerase; Region: DXP_reductoisom; pfam02670
335659009586	1-deoxy-D-xylulose 5-phosphate reductoisomerase C-terminal; Region: DXP_redisom_C; pfam08436
335659009587	DXP reductoisomerase C-terminal domain; Region: DXPR_C; pfam13288
335659009588	Predicted membrane-associated Zn-dependent proteases 1 [Cell envelope biogenesis, outer membrane]; Region: COG0750
335659009589	RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163
335659009590	active site
335659009591	PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989
335659009592	protein binding site [polypeptide binding]; other site
335659009593	RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163
335659009594	putative substrate binding region [chemical binding]; other site
335659009595	outer membrane protein assembly complex, YaeT protein; Region: OM_YaeT; TIGR03303
335659009596	Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244
335659009597	Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244
335659009598	Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244
335659009599	Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244
335659009600	Surface antigen; Region: Bac_surface_Ag; pfam01103
335659009601	UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase; Provisional; Region: lpxD; PRK00892
335659009602	UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase, LpxD; Region: LpxD; pfam04613
335659009603	UDP-3-O-acyl-glucosamine N-acyltransferase (LpxD): The enzyme catalyzes the transfer of 3-hydroxymyristic acid or 3-hydroxy-arachidic acid, depending on the organism, from the acyl carrier protein (ACP) to UDP-3-O-acyl-glucosamine to produce UDP-2; Region: LbH_LpxD; cd03352
335659009604	trimer interface [polypeptide binding]; other site
335659009605	active site
335659009606	UDP-GlcNAc binding site [chemical binding]; other site
335659009607	lipid binding site [chemical binding]; lipid-binding site
335659009608	FabZ is a 17kD beta-hydroxyacyl-acyl carrier protein (ACP) dehydratase that primarily catalyzes the dehydration of beta-hydroxyacyl-ACP to trans-2-acyl-ACP, the third step in the elongation phase of the bacterial/ plastid, type II, fatty-acid...; Region: FabZ; cd01288
335659009609	KTSC domain; Region: KTSC; pfam13619
335659009610	UDP-N-acetylglucosamine acyltransferase; Provisional; Region: PRK05289
335659009611	UDP-N-acetylglucosamine O-acyltransferase (UDP-GlcNAc acyltransferase): Proteins in this family catalyze the transfer of (R)-3-hydroxymyristic acid from its acyl carrier protein thioester to UDP-GlcNAc. It is the first enzyme in the lipid A biosynthetic...; Region: LbH_UDP-GlcNAc_AT; cd03351
335659009612	active site
335659009613	Protein of unknown function (DUF1009); Region: DUF1009; pfam06230
335659009614	lipid-A-disaccharide synthase; Reviewed; Region: lpxB; PRK00025
335659009615	ipid-A-disaccharide synthase; Provisional; Region: PRK14089
335659009616	Escherichia coli (Ec) citrate synthase (CS) GltA_like. CS catalyzes the condensation of acetyl coenzyme A (AcCoA) and oxalacetate (OAA) to form citrate and coenzyme A (CoA), the first step in the citric acid cycle (TCA or Krebs cycle). The overall CS...; Region: EcCS_like; cd06114
335659009617	Citrate synthase [Energy production and conversion]; Region: GltA; COG0372
335659009618	dimer interface [polypeptide binding]; other site
335659009619	active site
335659009620	citrylCoA binding site [chemical binding]; other site
335659009621	NADH binding [chemical binding]; other site
335659009622	cationic pore residues; other site
335659009623	oxalacetate/citrate binding site [chemical binding]; other site
335659009624	coenzyme A binding site [chemical binding]; other site
335659009625	catalytic triad [active]
335659009626	glutamyl-tRNA synthetase; Reviewed; Region: gltX; PRK01406
335659009627	catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808
335659009628	HIGH motif; other site
335659009629	catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808
335659009630	active site
335659009631	KMSKS motif; other site
335659009632	glutaminyl-tRNA synthetase; Provisional; Region: PRK05347
335659009633	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
335659009634	active site
335659009635	HIGH motif; other site
335659009636	nucleotide binding site [chemical binding]; other site
335659009637	catalytic core domain of glutaminyl-tRNA synthetase; Region: GlnRS_core; cd00807
335659009638	KMSKS motif; other site
335659009639	tRNA synthetases class I (E and Q), anti-codon binding domain; Region: tRNA-synt_1c_C; pfam03950
335659009640	SnoaL-like domain; Region: SnoaL_3; pfam13474
335659009641	Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cd00531
335659009642	Uncharacterized protein conserved in bacteria (DUF2171); Region: DUF2171; pfam09939
335659009643	Domain of unknown function (DUF4131); Region: DUF4131; pfam13567
335659009644	Predicted membrane metal-binding protein [General function prediction only]; Region: ComEC; COG0658
335659009645	Competence protein; Region: Competence; pfam03772
335659009646	LexA repressor; Validated; Region: PRK00215
335659009647	LexA DNA binding domain; Region: LexA_DNA_bind; pfam01726
335659009648	Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529
335659009649	Catalytic site [active]
335659009650	Molybdopterin biosynthesis enzyme [Coenzyme metabolism]; Region: MoeA; COG0303
335659009651	MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoeA; cd00887
335659009652	dimer interface [polypeptide binding]; other site
335659009653	putative functional site; other site
335659009654	putative MPT binding site; other site
335659009655	Haloacid dehalogenase-like hydrolase; Region: HAD_2; pfam13419
335659009656	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
335659009657	motif II; other site
335659009658	Family of homologous FMN-dependent alpha-hydroxyacid oxidizing enzymes. This family occurs in both prokaryotes and eukaryotes. Members of this family include flavocytochrome b2 (FCB2), glycolate oxidase (GOX), lactate monooxygenase (LMO), mandelate...; Region: alpha_hydroxyacid_oxid_FMN; cd02809
335659009659	FMN-dependent dehydrogenase; Region: FMN_dh; pfam01070
335659009660	active site
335659009661	substrate binding site [chemical binding]; other site
335659009662	FMN binding site [chemical binding]; other site
335659009663	putative catalytic residues [active]
335659009664	C-terminal processing peptidase family S41; Region: Peptidase_S41; cl02526
335659009665	Periplasmic protease [Cell envelope biogenesis, outer membrane]; Region: Prc; COG0793
335659009666	PDZ domain of C-terminal processing-, tail-specific-, and tricorn proteases, which function in posttranslational protein processing, maturation, and disassembly or degradation, in Bacteria, Archaea, and plant chloroplasts. May be responsible for...; Region: PDZ_CTP_protease; cd00988
335659009667	protein binding site [polypeptide binding]; other site
335659009668	C-terminal processing peptidase; serine protease family S41; Region: Peptidase_S41_CPP; cd07560
335659009669	Catalytic dyad [active]
335659009670	PAS fold; Region: PAS_7; pfam12860
335659009671	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
335659009672	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
335659009673	metal binding site [ion binding]; metal-binding site
335659009674	active site
335659009675	I-site; other site
335659009676	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
335659009677	Flp pilus assembly protein, pilin Flp [Intracellular trafficking and secretion]; Region: Flp; COG3847
335659009678	MoaC family, prokaryotic and eukaryotic. Members of this family are involved in molybdenum cofactor (Moco) biosynthesis, an essential cofactor of a diverse group of redox enzymes. MoaC, a small hexameric protein, converts, together with MoaA, a guanosine...; Region: MoaC_PE; cd01420
335659009679	trimer interface [polypeptide binding]; other site
335659009680	dimer interface [polypeptide binding]; other site
335659009681	putative active site [active]
335659009682	Indole-3-glycerol phosphate synthase (IGPS); an enzyme in the tryptophan biosynthetic pathway, catalyzing the ring closure reaction of 1-(o-carboxyphenylamino)-1-deoxyribulose-5-phosphate (CdRP) to indole-3-glycerol phosphate (IGP), accompanied by the...; Region: IGPS; cd00331
335659009683	active site
335659009684	ribulose/triose binding site [chemical binding]; other site
335659009685	phosphate binding site [ion binding]; other site
335659009686	substrate (anthranilate) binding pocket [chemical binding]; other site
335659009687	product (indole) binding pocket [chemical binding]; other site
335659009688	anthranilate phosphoribosyltransferase; Provisional; Region: trpD; PRK00188
335659009689	Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885
335659009690	Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591
335659009691	periplasmic folding chaperone; Provisional; Region: PRK10788
335659009692	SurA N-terminal domain; Region: SurA_N_3; cl07813
335659009693	PPIC-type PPIASE domain; Region: Rotamase_2; pfam13145
335659009694	Triosephosphate isomerase (TIM) is a glycolytic enzyme that catalyzes the interconversion of dihydroxyacetone phosphate and D-glyceraldehyde-3-phosphate. The reaction is very efficient and requires neither cofactors nor metal ions. TIM, usually...; Region: TIM; cd00311
335659009695	triosephosphate isomerase; Provisional; Region: PRK14565
335659009696	substrate binding site [chemical binding]; other site
335659009697	dimer interface [polypeptide binding]; other site
335659009698	catalytic triad [active]
335659009699	preprotein translocase subunit SecG; Reviewed; Region: secG; PRK06870
335659009700	CTP synthetase; Validated; Region: pyrG; PRK05380
335659009701	CTP synthetase (CTPs) is a two-domain protein, which consists of an N-terminal synthetase domain and C-terminal glutaminase domain. The enzymes hydrolyze the amide bond of glutamine to ammonia and glutamate at the glutaminase domains and transfer nascent...; Region: CTGs; cd03113
335659009702	Catalytic site [active]
335659009703	active site
335659009704	UTP binding site [chemical binding]; other site
335659009705	Type 1 glutamine amidotransferase (GATase1) domain found in Cytidine Triphosphate Synthetase; Region: GATase1_CTP_Synthase; cd01746
335659009706	active site
335659009707	putative oxyanion hole; other site
335659009708	catalytic triad [active]
335659009709	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173
335659009710	S-adenosylmethionine binding site [chemical binding]; other site
335659009711	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
335659009712	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
335659009713	dimer interface [polypeptide binding]; other site
335659009714	phosphorylation site [posttranslational modification]
335659009715	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
335659009716	ATP binding site [chemical binding]; other site
335659009717	Mg2+ binding site [ion binding]; other site
335659009718	G-X-G motif; other site
335659009719	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
335659009720	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
335659009721	active site
335659009722	phosphorylation site [posttranslational modification]
335659009723	intermolecular recognition site; other site
335659009724	dimerization interface [polypeptide binding]; other site
335659009725	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
335659009726	DNA binding site [nucleotide binding]
335659009727	NIPSNAP; Region: NIPSNAP; pfam07978
335659009728	DAHP synthetase I family; Region: DAHP_synth_1; pfam00793
335659009729	2-dehydro-3-deoxyphosphooctonate aldolase; Provisional; Region: PRK05198
335659009730	Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814
335659009731	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
335659009732	putative substrate translocation pore; other site
335659009733	HAMP domain; Region: HAMP; pfam00672
335659009734	Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283
335659009735	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
335659009736	dimer interface [polypeptide binding]; other site
335659009737	putative CheW interface [polypeptide binding]; other site
335659009738	Glutaminase [Amino acid transport and metabolism]; Region: GlsA; COG2066
335659009739	Glutaminase; Region: Glutaminase; cl00907
335659009740	Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659
335659009741	Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function; Region: STAS_SulP_like_sulfate_transporter; cd07042
335659009742	cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664
335659009743	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
335659009744	ligand binding site [chemical binding]; other site
335659009745	flexible hinge region; other site
335659009746	Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531
335659009747	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199
335659009748	7-cyano-7-deazaguanine reductase; Provisional; Region: PRK13258
335659009749	enolase; Provisional; Region: eno; PRK00077
335659009750	Enolase: Enolases are homodimeric enzymes that catalyse the reversible dehydration of 2-phospho-D-glycerate to phosphoenolpyruvate as part of the glycolytic and gluconeogenesis pathways. The reaction is facilitated by the presence of metal ions; Region: enolase; cd03313
335659009751	dimer interface [polypeptide binding]; other site
335659009752	metal binding site [ion binding]; metal-binding site
335659009753	substrate binding pocket [chemical binding]; other site
335659009754	2-enoyl thioester reductase (ETR) like proteins, child 1; Region: ETR_like_1; cd08291
335659009755	NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604
335659009756	NADP binding site [chemical binding]; other site
335659009757	dimer interface [polypeptide binding]; other site
335659009758	Short-chain alcohol dehydrogenase of unknown specificity [General function prediction only]; Region: COG4221
335659009759	classical (c) SDRs; Region: SDR_c; cd05233
335659009760	NAD(P) binding site [chemical binding]; other site
335659009761	active site
335659009762	Cupin; Region: Cupin_6; pfam12852
335659009763	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
335659009764	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
335659009765	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
335659009766	Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849
335659009767	Predicted flavoprotein [General function prediction only]; Region: COG0431
335659009768	NADPH-dependent FMN reductase; Region: FMN_red; pfam03358
335659009769	Septum formation initiator [Cell division and chromosome partitioning]; Region: COG2919
335659009770	Septum formation initiator; Region: DivIC; pfam04977
335659009771	pyruvate dehydrogenase E1 component, alpha subunit; Region: PDH_E1_alph_y; TIGR03182
335659009772	Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000
335659009773	tetramer interface [polypeptide binding]; other site
335659009774	TPP-binding site [chemical binding]; other site
335659009775	heterodimer interface [polypeptide binding]; other site
335659009776	phosphorylation loop region [posttranslational modification]
335659009777	pyruvate dehydrogenase subunit beta; Provisional; Region: PRK11892
335659009778	Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849
335659009779	E3 interaction surface; other site
335659009780	lipoyl attachment site [posttranslational modification]; other site
335659009781	Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036
335659009782	alpha subunit interface [polypeptide binding]; other site
335659009783	TPP binding site [chemical binding]; other site
335659009784	heterodimer interface [polypeptide binding]; other site
335659009785	Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780
335659009786	Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285
335659009787	nucleoside/Zn binding site; other site
335659009788	dimer interface [polypeptide binding]; other site
335659009789	catalytic motif [active]
335659009790	Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849
335659009791	E3 interaction surface; other site
335659009792	lipoyl attachment site [posttranslational modification]; other site
335659009793	e3 binding domain; Region: E3_binding; pfam02817
335659009794	dihydrolipoamide acetyltransferase; Reviewed; Region: PRK11857
335659009795	2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198
335659009796	dihydrolipoamide dehydrogenase; Reviewed; Region: PRK06416
335659009797	Anaerobic glycerol-3-phosphate dehydrogenase [Amino acid transport and metabolism]; Region: GlpB; cl17730
335659009798	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
335659009799	Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852
335659009800	threonine synthase; Validated; Region: PRK08197
335659009801	Threonine synthase is a pyridoxal phosphate (PLP) dependent enzyme that catalyses the last reaction in the synthesis of  threonine from aspartate. It proceeds by converting O-phospho-L-homoserine (OPH) into threonine and inorganic phosphate. In plants; Region: Thr-synth_1; cd01563
335659009802	homodimer interface [polypeptide binding]; other site
335659009803	pyridoxal 5'-phosphate binding site [chemical binding]; other site
335659009804	catalytic residue [active]
335659009805	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3181
335659009806	Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741
335659009807	Lytic Transglycosylase (LT)  and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL).  LTs...; Region: LT_GEWL; cd00254
335659009808	N-acetyl-D-glucosamine binding site [chemical binding]; other site
335659009809	catalytic residue [active]
335659009810	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
335659009811	dimerization interface [polypeptide binding]; other site
335659009812	Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114
335659009813	cyclase homology domain; Region: CHD; cd07302
335659009814	nucleotidyl binding site; other site
335659009815	metal binding site [ion binding]; metal-binding site
335659009816	dimer interface [polypeptide binding]; other site
335659009817	cobalamin riboswitch as predicted by Rfam v8.1 (RF00174), score 138.74
335659009818	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244
335659009819	TonB-dependent siderophore receptor; Region: TonB-siderophor; TIGR01783
335659009820	dihydroxy-acid dehydratase; Provisional; Region: PRK00911
335659009821	FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790
335659009822	Sel1-like repeats; Region: SEL1; smart00671
335659009823	Escherichia coli exonuclease III (ExoIII) and Neisseria meningitides NExo-like subfamily of the ExoIII family purinic/apyrimidinic (AP) endonucleases; Region: ExoIII-like_AP-endo; cd09086
335659009824	putative catalytic site [active]
335659009825	putative phosphate binding site [ion binding]; other site
335659009826	active site
335659009827	metal binding site A [ion binding]; metal-binding site
335659009828	DNA binding site [nucleotide binding]
335659009829	putative AP binding site [nucleotide binding]; other site
335659009830	putative metal binding site B [ion binding]; other site
335659009831	PAS fold; Region: PAS_4; pfam08448
335659009832	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
335659009833	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
335659009834	dimer interface [polypeptide binding]; other site
335659009835	phosphorylation site [posttranslational modification]
335659009836	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
335659009837	ATP binding site [chemical binding]; other site
335659009838	Mg2+ binding site [ion binding]; other site
335659009839	G-X-G motif; other site
335659009840	FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784
335659009841	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
335659009842	active site
335659009843	phosphorylation site [posttranslational modification]
335659009844	intermolecular recognition site; other site
335659009845	dimerization interface [polypeptide binding]; other site
335659009846	Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326
335659009847	Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695
335659009848	Fe-S cluster assembly scaffold protein [Posttranslational modification, protein turnover, chaperones]; Region: sufA; COG0316
335659009849	deoxyguanosinetriphosphate triphosphohydrolase-like protein; Provisional; Region: PRK01286
335659009850	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
335659009851	Zn2+ binding site [ion binding]; other site
335659009852	Mg2+ binding site [ion binding]; other site
335659009853	Phosphohydrolase-associated domain; Region: HD_assoc; pfam13286
335659009854	Arginyl tRNA synthetase N terminal dom; Region: Arg_tRNA_synt_N; smart01016
335659009855	arginyl-tRNA synthetase; Reviewed; Region: argS; PRK01611
335659009856	catalytic core domain of arginyl-tRNA synthetases; Region: ArgRS_core; cd00671
335659009857	active site
335659009858	HIGH motif; other site
335659009859	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
335659009860	KMSK motif region; other site
335659009861	tRNA binding surface [nucleotide binding]; other site
335659009862	DALR anticodon binding domain; Region: DALR_1; smart00836
335659009863	anticodon binding site; other site
335659009864	Sporulation related domain; Region: SPOR; pfam05036
335659009865	Beta-glucosidase-related glycosidases [Carbohydrate transport and metabolism]; Region: BglX; COG1472
335659009866	Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; cl07971
335659009867	Rec8/ScpA/Scc1-like protein (kleisin family) [Replication,    recombination, and repair]; Region: scpA; COG1354
335659009868	Putative transcriptional regulators (Ypuh-like); Region: DUF387; pfam04079
335659009869	twin arginine translocase protein A; Provisional; Region: tatA; PRK00720
335659009870	twin arginine translocase protein A; Provisional; Region: tatA; PRK00575
335659009871	twin arginine-targeting protein translocase TatB; Region: tatB; TIGR01410
335659009872	Sec-independent protein secretion pathway component TatC [Intracellular trafficking and secretion]; Region: TatC; COG0805
335659009873	seryl-tRNA synthetase; Provisional; Region: PRK05431
335659009874	Seryl-tRNA synthetase N-terminal domain; Region: Seryl_tRNA_N; pfam02403
335659009875	Seryl-tRNA synthetase (SerRS) class II core catalytic domain. SerRS is responsible for the attachment of serine to the 3' OH group of ribose of the appropriate tRNA. This domain It is primarily responsible for ATP-dependent formation of the enzyme...; Region: SerRS_core; cd00770
335659009876	dimer interface [polypeptide binding]; other site
335659009877	active site
335659009878	motif 1; other site
335659009879	motif 2; other site
335659009880	motif 3; other site
335659009881	5'(3')-nucleotidase/polyphosphatase; Provisional; Region: surE; PRK00346
335659009882	FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784
335659009883	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
335659009884	active site
335659009885	phosphorylation site [posttranslational modification]
335659009886	intermolecular recognition site; other site
335659009887	dimerization interface [polypeptide binding]; other site
335659009888	protein-L-isoaspartate O-methyltransferase; Reviewed; Region: pcm; PRK00312
335659009889	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
335659009890	S-adenosylmethionine binding site [chemical binding]; other site
335659009891	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
335659009892	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
335659009893	Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739
335659009894	Peptidase family M23; Region: Peptidase_M23; pfam01551
335659009895	Predicted ATPase (AAA+ superfamily) [General function prediction only]; Region: COG2607
335659009896	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
335659009897	Walker A motif; other site
335659009898	ATP binding site [chemical binding]; other site
335659009899	Walker B motif; other site
335659009900	Preprotein translocase subunit; Region: YajC; pfam02699
335659009901	preprotein translocase subunit SecD; Reviewed; Region: secD; PRK05812
335659009902	SecD/SecF GG Motif; Region: Sec_GG; pfam07549
335659009903	protein-export membrane protein, SecD/SecF family; Region: 2A0604s01; TIGR00916
335659009904	preprotein translocase subunit SecF; Reviewed; Region: secF; PRK13022
335659009905	SecD/SecF GG Motif; Region: Sec_GG; pfam07549
335659009906	Protein export membrane protein; Region: SecD_SecF; pfam02355
335659009907	Mth938-like domain. The members of this family include: Mth938, 2P1, Xcr35, Rpa2829, and several uncharacterized sequences. Mth938 is a hypothetical protein encoded by the Methanobacterium thermoautotrophicum (Mth) genome. This protein crystallizes as a...; Region: Mth938-like; cd00248
335659009908	Squalene/phytoene synthase; Region: SQS_PSY; pfam00494
335659009909	substrate binding pocket [chemical binding]; other site
335659009910	substrate-Mg2+ binding site; other site
335659009911	aspartate-rich region 1; other site
335659009912	aspartate-rich region 2; other site
335659009913	threonine dehydratase; Provisional; Region: PRK07334
335659009914	Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562
335659009915	tetramer interface [polypeptide binding]; other site
335659009916	pyridoxal 5'-phosphate binding site [chemical binding]; other site
335659009917	catalytic residue [active]
335659009918	C-terminal ACT domain of biodegradative (catabolic) threonine dehydratase II (ThrD-II) and other related ACT domains; Region: ACT_ThrD-II-like; cd04886
335659009919	Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520
335659009920	Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321
335659009921	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
335659009922	catalytic residue [active]
335659009923	SCP_bacterial: SCP-like extracellular protein domain, as found in bacteria and archaea. The wider family of SCP containing proteins includes plant pathogenesis-related protein 1 (PR-1), CRISPs, mammalian cysteine-rich secretory proteins, and allergen 5...; Region: SCP_bacterial; cd05379
335659009924	serine/threonine protein kinase; Provisional; Region: PRK09188
335659009925	serine/threonine protein kinase; Provisional; Region: PRK12274
335659009926	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
335659009927	tRNA (uracil-5-)-methyltransferase Gid; Reviewed; Region: PRK05335
335659009928	Glucose inhibited division protein A; Region: GIDA; pfam01134
335659009929	Domain of unknown function (DUF1127); Region: DUF1127; pfam06568
335659009930	lytic murein transglycosylase; Region: MltB_2; TIGR02283
335659009931	Lytic Transglycosylase (LT)  and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL).  LTs...; Region: LT_GEWL; cd00254
335659009932	N-acetyl-D-glucosamine binding site [chemical binding]; other site
335659009933	Predicted integral membrane protein (DUF2189); Region: DUF2189; cl02291
335659009934	Domain of unknown function (DUF3597); Region: DUF3597; pfam12200
335659009935	Predicted acetyltransferase [General function prediction only]; Region: COG2388
335659009936	Predicted acetyltransferase [General function prediction only]; Region: COG2388
335659009937	Protein of unknown function (DUF3828); Region: DUF3828; pfam12883
335659009938	acyl-CoA synthetase; Validated; Region: PRK07470
335659009939	Bacterial Bile acid CoA ligases and similar proteins; Region: BACL_like; cd05929
335659009940	acyl-activating enzyme (AAE) consensus motif; other site
335659009941	putative AMP binding site [chemical binding]; other site
335659009942	putative active site [active]
335659009943	putative CoA binding site [chemical binding]; other site
335659009944	Protein of unknown function (DUF1217); Region: DUF1217; pfam06748
335659009945	Protein of unknown function (DUF1217); Region: DUF1217; pfam06748
335659009946	Protein of unknown function (DUF1217); Region: DUF1217; pfam06748
335659009947	Protein of unknown function (DUF1217); Region: DUF1217; pfam06748
335659009948	Protein of unknown function (DUF1217); Region: DUF1217; pfam06748
335659009949	Predicted ATPase [General function prediction only]; Region: COG3910
335659009950	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
335659009951	Walker A/P-loop; other site
335659009952	ATP binding site [chemical binding]; other site
335659009953	Q-loop/lid; other site
335659009954	ABC transporter signature motif; other site
335659009955	Walker B; other site
335659009956	D-loop; other site
335659009957	H-loop/switch region; other site
335659009958	Pyrabactin resistance 1 (PYR1), PYR1-like (PYL), regulatory component of abscisic acid receptors (RCARs), and related proteins; Region: PYR_PYL_RCAR_like; cd07821
335659009959	putative hydrophobic ligand binding site [chemical binding]; other site
335659009960	protein interface [polypeptide binding]; other site
335659009961	gate; other site
335659009962	PQQ-dependent catabolism-associated beta-propeller protein; Region: PQQ_ABC_repeats; TIGR03866
335659009963	40-residue YVTN family beta-propeller repeat; Region: beta_rpt_yvtn; TIGR02276
335659009964	40-residue YVTN family beta-propeller repeat; Region: beta_rpt_yvtn; TIGR02276
335659009965	40-residue YVTN family beta-propeller repeat; Region: beta_rpt_yvtn; TIGR02276
335659009966	40-residue YVTN family beta-propeller repeat; Region: beta_rpt_yvtn; TIGR02276
335659009967	Predicted phosphatases [General function prediction only]; Region: Gph; COG0546
335659009968	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
335659009969	motif II; other site
335659009970	Uncharacterized protein conserved in bacteria [Function unknown]; Region: DinB; COG2318
335659009971	DinB superfamily; Region: DinB_2; pfam12867
335659009972	excinuclease ABC subunit A; Reviewed; Region: uvrA; PRK00349
335659009973	ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270
335659009974	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
335659009975	ABC transporter signature motif; other site
335659009976	Walker B; other site
335659009977	D-loop; other site
335659009978	H-loop/switch region; other site
335659009979	ATP-binding cassette domain II of the excision repair protein UvrA; Region: ABC_UvrA_II; cd03271
335659009980	Opacity protein and related surface antigens [Cell envelope biogenesis, outer membrane]; Region: COG3637
335659009981	Opacity protein and related surface antigens [Cell envelope biogenesis, outer membrane]; Region: COG3637
335659009982	Opacity protein and related surface antigens [Cell envelope biogenesis, outer membrane]; Region: COG3637
335659009983	Opacity protein and related surface antigens [Cell envelope biogenesis, outer membrane]; Region: COG3637
335659009984	Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629
335659009985	SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496
335659009986	dimer interface [polypeptide binding]; other site
335659009987	ssDNA binding site [nucleotide binding]; other site
335659009988	tetramer (dimer of dimers) interface [polypeptide binding]; other site
335659009989	DNA gyrase, A subunit; Region: gyrA; TIGR01063
335659009990	DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187
335659009991	CAP-like domain; other site
335659009992	active site
335659009993	primary dimer interface [polypeptide binding]; other site
335659009994	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
335659009995	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
335659009996	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
335659009997	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
335659009998	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
335659009999	K+ potassium transporter; Region: K_trans; pfam02705
335659010000	phosphopantetheine adenylyltransferase; Provisional; Region: coaD; PRK00168
335659010001	Phosphopantetheine adenylyltransferase; Region: PPAT; cd02163
335659010002	active site
335659010003	(T/H)XGH motif; other site
335659010004	cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the...; Region: cyclophilin; cd00317
335659010005	active site
335659010006	cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the...; Region: cyclophilin; cd00317
335659010007	active site
335659010008	S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Provisional; Region: queA; PRK00147
335659010009	S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Region: queA; TIGR00113
335659010010	Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340
335659010011	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
335659010012	Transposase DDE domain; Region: DDE_Tnp_1_3; pfam13612
335659010013	Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586
335659010014	aspartate-semialdehyde dehydrogenase; Provisional; Region: PRK14874
335659010015	Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859
335659010016	Peptidase propeptide and YPEB domain; Region: PepSY; pfam03413
335659010017	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
335659010018	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
335659010019	AefR-like transcriptional repressor, C-terminal region; Region: TetR_C_7; pfam14246
335659010020	Patatins and Phospholipases; Region: Patatin_and_cPLA2; cl11396
335659010021	nucleophile elbow; other site
335659010022	queuine tRNA-ribosyltransferase; Provisional; Region: tgt; PRK00112
335659010023	Queuine/archaeosine tRNA-ribosyltransferase [Translation, ribosomal structure and biogenesis]; Region: Tgt; COG0343
335659010024	Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031
335659010025	CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561
335659010026	dimer interface [polypeptide binding]; other site
335659010027	pyridoxal 5'-phosphate binding site [chemical binding]; other site
335659010028	catalytic residue [active]
335659010029	Domain of unknown function (DUF4415); Region: DUF4415; pfam14384
335659010030	Uncharacterized protein containing caspase domain [General function prediction only]; Region: COG4249
335659010031	Caspase domain; Region: Peptidase_C14; pfam00656
335659010032	Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471
335659010033	EamA-like transporter family; Region: EamA; pfam00892
335659010034	Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697
335659010035	EamA-like transporter family; Region: EamA; pfam00892
335659010036	YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448
335659010037	homotrimer interaction site [polypeptide binding]; other site
335659010038	putative active site [active]
335659010039	Formyl transferase catalytic core domain found in a group of proteins with unknown functions; Region: FMT_core_like_2; cd08822
335659010040	putative active site [active]
335659010041	putative substrate binding site [chemical binding]; other site
335659010042	putative cosubstrate binding site; other site
335659010043	catalytic site [active]
335659010044	acetoacetyl-CoA synthetase; Provisional; Region: PRK03584
335659010045	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
335659010046	acyl-activating enzyme (AAE) consensus motif; other site
335659010047	AMP binding site [chemical binding]; other site
335659010048	active site
335659010049	CoA binding site [chemical binding]; other site
335659010050	Opacity protein and related surface antigens [Cell envelope biogenesis, outer membrane]; Region: COG3637
335659010051	Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; cl00465
335659010052	Domain of unknown function DUF20; Region: UPF0118; pfam01594
335659010053	Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cd02883
335659010054	nudix motif; other site
335659010055	Exo-beta-1,3-glucanase [Carbohydrate transport and metabolism]; Region: COG5309
335659010056	Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641
335659010057	NdvC_like  proteins in this family are putative bacterial beta-(1,6)-glucosyltransferase; Region: CESA_NdvC_like; cd06435
335659010058	Ligand binding site; other site
335659010059	DXD motif; other site
335659010060	Exo-beta-1,3-glucanase [Carbohydrate transport and metabolism]; Region: COG5309
335659010061	bifunctional N-acetylglucosamine-1-phosphate uridyltransferase/glucosamine-1-phosphate acetyltransferase; Provisional; Region: glmU; PRK14353
335659010062	N-terminal domain of bacterial GlmU; Region: GT2_GlmU_N_bac; cd02540
335659010063	Substrate binding site; other site
335659010064	Mg++ binding site; other site
335659010065	N-acetyl-glucosamine-1-phosphate uridyltransferase (GlmU), C-terminal left-handed beta-helix (LbH) acetyltransferase domain: GlmU is also known as UDP-N-acetylglucosamine pyrophosphorylase. It is a bifunctional bacterial enzyme that catalyzes two...; Region: LbH_GlmU_C; cd03353
335659010066	active site
335659010067	substrate binding site [chemical binding]; other site
335659010068	CoA binding site [chemical binding]; other site
335659010069	glucosamine--fructose-6-phosphate aminotransferase; Reviewed; Region: PRK00331
335659010070	Glutamine amidotransferases class-II (Gn-AT)_GFAT-type. This domain is found at the N-terminus of glucosamine-6P synthase (GlmS, or GFAT in humans).  The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the appropriate substrate. In...; Region: GFAT; cd00714
335659010071	glutaminase active site [active]
335659010072	SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008
335659010073	dimer interface [polypeptide binding]; other site
335659010074	active site
335659010075	SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009
335659010076	dimer interface [polypeptide binding]; other site
335659010077	active site
335659010078	Uncharacterized conserved protein [Function unknown]; Region: COG2928
335659010079	3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084
335659010080	Domain of unknown function (DUF1932); Region: DUF1932; pfam09130
335659010081	2-dehydropantoate 2-reductase; Provisional; Region: PRK12921
335659010082	Ketopantoate reductase PanE/ApbA; Region: ApbA; pfam02558
335659010083	Ketopantoate reductase PanE/ApbA C terminal; Region: ApbA_C; pfam08546
335659010084	ATP-dependent DNA helicase RecG; Provisional; Region: PRK10917
335659010085	RecG_wedge_OBF: A subfamily of OB folds corresponding to the OB fold found in the N-terminal (wedge) domain of Escherichia coli RecG. RecG is a branched-DNA-specific helicase, which catalyzes the interconversion of a DNA replication fork to a...; Region: RecG_wedge_OBF; cd04488
335659010086	ssDNA binding site; other site
335659010087	generic binding surface II; other site
335659010088	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
335659010089	ATP binding site [chemical binding]; other site
335659010090	putative Mg++ binding site [ion binding]; other site
335659010091	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
335659010092	nucleotide binding region [chemical binding]; other site
335659010093	ATP-binding site [chemical binding]; other site
335659010094	Uncharacterized conserved protein [Function unknown]; Region: COG2938
335659010095	Transcription-repair coupling factor (superfamily II helicase) [DNA replication, recombination, and repair / Transcription]; Region: Mfd; COG1197
335659010096	CarD-like/TRCF domain; Region: CarD_TRCF; smart01058
335659010097	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
335659010098	ATP binding site [chemical binding]; other site
335659010099	putative Mg++ binding site [ion binding]; other site
335659010100	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
335659010101	nucleotide binding region [chemical binding]; other site
335659010102	ATP-binding site [chemical binding]; other site
335659010103	This domain is found in proteins necessary for strand-specific repair in DNA such as TRCF in Escherichia coli; Region: TRCF; smart00982
335659010104	Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea.  CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458
335659010105	DNA-binding site [nucleotide binding]; DNA binding site
335659010106	RNA-binding motif; other site
335659010107	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
335659010108	acyl-activating enzyme (AAE) consensus motif; other site
335659010109	CoA binding site [chemical binding]; other site
335659010110	ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166
335659010111	The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_14; cd08497
335659010112	Invasion associated locus B (IalB) protein; Region: IalB; pfam06776
335659010113	Hemimethylated DNA-binding protein YccV like; Region: YccV-like; pfam08755
335659010114	Predicted permeases [General function prediction only]; Region: COG0679
335659010115	2-octaprenyl-6-methoxyphenyl hydroxylase; Provisional; Region: PRK07494
335659010116	ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314
335659010117	CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; pfam01066
335659010118	Membrane protein TerC, possibly involved in tellurium resistance [Inorganic ion transport and metabolism]; Region: TerC; COG0861
335659010119	quinone oxidoreductase, NADPH-dependent; Provisional; Region: PRK10754
335659010120	Quinone oxidoreductase (QOR); Region: QOR2; cd05286
335659010121	NADP binding site [chemical binding]; other site
335659010122	dimer interface [polypeptide binding]; other site
335659010123	acetylornithine transaminase protein; Provisional; Region: argD; PRK03715
335659010124	Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610
335659010125	inhibitor-cofactor binding pocket; inhibition site
335659010126	pyridoxal 5'-phosphate binding site [chemical binding]; other site
335659010127	catalytic residue [active]
335659010128	TPR repeat; Region: TPR_11; pfam13414
335659010129	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
335659010130	binding surface
335659010131	TPR motif; other site
335659010132	TPR repeat; Region: TPR_11; pfam13414
335659010133	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
335659010134	binding surface
335659010135	TPR motif; other site
335659010136	TPR repeat; Region: TPR_11; pfam13414
335659010137	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
335659010138	binding surface
335659010139	TPR motif; other site
335659010140	TPR repeat; Region: TPR_11; pfam13414
335659010141	Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789
335659010142	Helix-Turn-Helix DNA binding domain of the MerR-like transcription regulators YyaN and YraB; Region: HTH_YyaN; cd01109
335659010143	DNA binding residues [nucleotide binding]
335659010144	putative dimer interface [polypeptide binding]; other site
335659010145	Carboxymuconolactone decarboxylase family; Region: CMD; cl00460
335659010146	ribosomal protein S12 methylthiotransferase; Provisional; Region: rimO; PRK14862
335659010147	Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919
335659010148	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
335659010149	FeS/SAM binding site; other site
335659010150	Response regulator with putative antiterminator output domain [Signal transduction mechanisms]; Region: AmiR; COG3707
335659010151	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
335659010152	active site
335659010153	phosphorylation site [posttranslational modification]
335659010154	intermolecular recognition site; other site
335659010155	ANTAR domain; Region: ANTAR; pfam03861
335659010156	ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components [Inorganic ion transport and metabolism]; Region: TauA; COG0715
335659010157	NMT1-like family; Region: NMT1_2; pfam13379
335659010158	ferredoxin-nitrite reductase; Reviewed; Region: nirA; PRK09567
335659010159	Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460
335659010160	Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460
335659010161	sulfite reductase; Provisional; Region: PRK06214
335659010162	Putative Fe-S cluster; Region: FeS; cl17515
335659010163	Cytochrome p450- like alpha subunits of E. coli sulfite reductase (SiR) multimerize with beta subunits to catalyze the NADPH dependent reduction of sulfite to sulfide. Beta subunits have an Fe4S4 cluster and a siroheme, while the alpha subunits (cysJ...; Region: SiR; cd06199
335659010164	FAD binding pocket [chemical binding]; other site
335659010165	FAD binding motif [chemical binding]; other site
335659010166	catalytic residues [active]
335659010167	NAD binding pocket [chemical binding]; other site
335659010168	phosphate binding motif [ion binding]; other site
335659010169	beta-alpha-beta structure motif; other site
335659010170	LamB/YcsF family of  lactam utilization protein; Region: LamB_YcsF_like; cd10787
335659010171	putative active site [active]
335659010172	Allophanate hydrolase subunit 2; Region: AHS2; smart00797
335659010173	Allophanate hydrolase subunit 1; Region: AHS1; smart00796
335659010174	Allophanate hydrolase subunit 1 [Amino acid transport and metabolism]; Region: DUR1; COG2049
335659010175	hypothetical protein; Validated; Region: PRK08245
335659010176	Uncharacterized conserved protein, contains double-stranded beta-helix domain [Function unknown]; Region: COG1917
335659010177	Short chain fatty acids transporter [Lipid metabolism]; Region: AtoE; COG2031
335659010178	Anaerobic dehydrogenases, typically selenocysteine-containing [Energy production and conversion]; Region: BisC; COG0243
335659010179	The MopB_Acetylene-hydratase CD contains acetylene hydratase (Ahy) and other related proteins. The acetylene hydratase of Pelobacter acetylenicus is a tungsten iron-sulfur protein involved in the fermentation of acetylene to ethanol and acetate. Members...; Region: MopB_Acetylene-hydratase; cd02759
335659010180	putative [Fe4-S4] binding site [ion binding]; other site
335659010181	putative molybdopterin cofactor binding site [chemical binding]; other site
335659010182	Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a  large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928
335659010183	Anaerobic dehydrogenases, typically selenocysteine-containing [Energy production and conversion]; Region: BisC; COG0243
335659010184	The MopB_CT_Acetylene-hydratase CD contains acetylene hydratase (Ahy) and other related proteins. The acetylene hydratase of Pelobacter acetylenicus is a tungsten iron-sulfur protein involved in the fermentation of acetylene to ethanol and acetate. This...; Region: MopB_CT_Acetylene-hydratase; cd02781
335659010185	putative molybdopterin cofactor binding site; other site
335659010186	Ferredoxin reductase (FNR), an FAD and NAD(P) binding protein, was intially identified as a chloroplast reductase activity, catalyzing the electron transfer from reduced iron-sulfur protein ferredoxin to NADP+ as the final step in the electron transport...; Region: FNR_like; cl06868
335659010187	Flavodoxin reductases (ferredoxin-NADPH reductases) family 1 [Energy production and conversion]; Region: Hmp; COG1018
335659010188	FAD binding pocket [chemical binding]; other site
335659010189	conserved FAD binding motif [chemical binding]; other site
335659010190	phosphate binding motif [ion binding]; other site
335659010191	beta-alpha-beta structure motif; other site
335659010192	NAD binding pocket [chemical binding]; other site
335659010193	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
335659010194	catalytic loop [active]
335659010195	iron binding site [ion binding]; other site
335659010196	Transcriptional regulators [Transcription]; Region: GntR; COG1802
335659010197	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
335659010198	DNA-binding site [nucleotide binding]; DNA binding site
335659010199	FCD domain; Region: FCD; pfam07729
335659010200	Uncharacterized protein conserved in bacteria (DUF2147); Region: DUF2147; pfam09917
335659010201	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
335659010202	Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497
335659010203	substrate binding pocket [chemical binding]; other site
335659010204	membrane-bound complex binding site; other site
335659010205	hinge residues; other site
335659010206	Domain of unknown function (DUF1993); Region: DUF1993; pfam09351
335659010207	Phosphoglycerate dehydrogenase and related dehydrogenases [Amino acid transport and metabolism]; Region: SerA; COG0111
335659010208	Phosphoglycerate dehydrogenases, NAD-binding and catalytic domains; Region: PGDH_4; cd12173
335659010209	ligand binding site [chemical binding]; other site
335659010210	NAD binding site [chemical binding]; other site
335659010211	dimerization interface [polypeptide binding]; other site
335659010212	catalytic site [active]
335659010213	glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650
335659010214	The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301
335659010215	Walker A/P-loop; other site
335659010216	ATP binding site [chemical binding]; other site
335659010217	Q-loop/lid; other site
335659010218	ABC transporter signature motif; other site
335659010219	Walker B; other site
335659010220	D-loop; other site
335659010221	H-loop/switch region; other site
335659010222	ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395
335659010223	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
335659010224	dimer interface [polypeptide binding]; other site
335659010225	conserved gate region; other site
335659010226	putative PBP binding loops; other site
335659010227	ABC-ATPase subunit interface; other site
335659010228	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
335659010229	dimer interface [polypeptide binding]; other site
335659010230	conserved gate region; other site
335659010231	putative PBP binding loops; other site
335659010232	ABC-ATPase subunit interface; other site
335659010233	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653
335659010234	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547
335659010235	LTXXQ motif family protein; Region: LTXXQ; pfam07813
335659010236	cheY-homologous receiver domain; Region: REC; smart00448
335659010237	phosphorylation site [posttranslational modification]
335659010238	intermolecular recognition site; other site
335659010239	hypothetical protein; Validated; Region: PRK00029
335659010240	Glucokinase; Region: Glucokinase; pfam02685
335659010241	glucokinase, proteobacterial type; Region: glk; TIGR00749
335659010242	Nicotinamidase/pyrazinamidase (PZase). Nicotinamidase, a ubiquitous enzyme in prokaryotes, converts nicotinamide to nicotinic acid (niacin) and ammonia, which in turn can be recycled to make nicotinamide adenine dinucleotide (NAD). The same enzyme is...; Region: nicotinamidase; cd01011
335659010243	Isochorismatase family; Region: Isochorismatase; pfam00857
335659010244	catalytic triad [active]
335659010245	metal binding site [ion binding]; metal-binding site
335659010246	conserved cis-peptide bond; other site
335659010247	alpha/beta hydrolase fold; Region: Abhydrolase_1; pfam00561
335659010248	PHB de-polymerase C-terminus; Region: PHB_depo_C; pfam06850
335659010249	NAD synthetase; Reviewed; Region: nadE; PRK02628
335659010250	Glutamine aminotransferase (GAT, glutaminase) domain of glutamine-dependent NAD synthetases (class 7 and 8 nitrilases); Region: GAT_Gln-NAD-synth; cd07570
335659010251	multimer interface [polypeptide binding]; other site
335659010252	active site
335659010253	catalytic triad [active]
335659010254	protein interface 1 [polypeptide binding]; other site
335659010255	NAD+ synthase is a homodimer, which catalyzes the final step in de novo nicotinamide adenine dinucleotide (NAD+) biosynthesis, an amide transfer from either ammonia or glutamine to nicotinic acid adenine dinucleotide (NaAD). The conversion of NaAD to NAD...; Region: NAD_synthase; cd00553
335659010256	homodimer interface [polypeptide binding]; other site
335659010257	NAD binding pocket [chemical binding]; other site
335659010258	ATP binding pocket [chemical binding]; other site
335659010259	Mg binding site [ion binding]; other site
335659010260	active-site loop [active]
335659010261	Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261
335659010262	AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cl12060
335659010263	Metal-binding active site; metal-binding site
335659010264	ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747
335659010265	The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_10; cd08515
335659010266	ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444
335659010267	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
335659010268	Walker A/P-loop; other site
335659010269	ATP binding site [chemical binding]; other site
335659010270	Q-loop/lid; other site
335659010271	ABC transporter signature motif; other site
335659010272	Walker B; other site
335659010273	D-loop; other site
335659010274	H-loop/switch region; other site
335659010275	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097
335659010276	ABC-type oligopeptide transport system, ATPase component [Amino acid transport and metabolism]; Region: AppF; COG4608
335659010277	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
335659010278	Walker A/P-loop; other site
335659010279	ATP binding site [chemical binding]; other site
335659010280	Q-loop/lid; other site
335659010281	ABC transporter signature motif; other site
335659010282	Walker B; other site
335659010283	D-loop; other site
335659010284	H-loop/switch region; other site
335659010285	oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727
335659010286	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601
335659010287	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
335659010288	dimer interface [polypeptide binding]; other site
335659010289	conserved gate region; other site
335659010290	putative PBP binding loops; other site
335659010291	ABC-ATPase subunit interface; other site
335659010292	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173
335659010293	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
335659010294	dimer interface [polypeptide binding]; other site
335659010295	conserved gate region; other site
335659010296	putative PBP binding loops; other site
335659010297	ABC-ATPase subunit interface; other site
335659010298	dihydroxy-acid dehydratase; Provisional; Region: PRK12448
335659010299	Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; cl00465
335659010300	Ion channel; Region: Ion_trans_2; pfam07885
335659010301	transcriptional regulator FixK; Provisional; Region: fixK; PRK09391
335659010302	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
335659010303	ligand binding site [chemical binding]; other site
335659010304	flexible hinge region; other site
335659010305	helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092
335659010306	putative switch regulator; other site
335659010307	non-specific DNA interactions [nucleotide binding]; other site
335659010308	DNA binding site [nucleotide binding]
335659010309	sequence specific DNA binding site [nucleotide binding]; other site
335659010310	putative cAMP binding site [chemical binding]; other site
335659010311	Response regulator [Signal transduction mechanisms]; Region: TtrR; COG4566
335659010312	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
335659010313	active site
335659010314	phosphorylation site [posttranslational modification]
335659010315	intermolecular recognition site; other site
335659010316	dimerization interface [polypeptide binding]; other site
335659010317	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
335659010318	DNA binding residues [nucleotide binding]
335659010319	dimerization interface [polypeptide binding]; other site
335659010320	Invasion associated locus B (IalB) protein; Region: IalB; pfam06776
335659010321	Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695
335659010322	aspartate-alanine antiporter; Region: Asp_Ala_antiprt; TIGR03802
335659010323	Predicted Permease Membrane Region; Region: Asp-Al_Ex; pfam06826
335659010324	TrkA-C domain; Region: TrkA_C; pfam02080
335659010325	Predicted Permease Membrane Region; Region: Asp-Al_Ex; pfam06826
335659010326	Protein of unknown function (DUF1275); Region: DUF1275; pfam06912
335659010327	Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659
335659010328	Sulfate transporter N-terminal domain with GLY motif; Region: Sulfate_tra_GLY; pfam13792
335659010329	Sulfate transporter family; Region: Sulfate_transp; pfam00916
335659010330	Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function; Region: STAS_SulP_like_sulfate_transporter; cd07042
335659010331	Arginine/lysine/ornithine decarboxylases [Amino acid transport and metabolism]; Region: LdcC; COG1982
335659010332	Ornithine decarboxylase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to ornithine decarboxylase (ODC), arginine decarboxylase (ADC) and lysine...; Region: Orn_deC_like; cd00615
335659010333	homodimer interface [polypeptide binding]; other site
335659010334	pyridoxal 5'-phosphate binding site [chemical binding]; other site
335659010335	catalytic residue [active]
335659010336	Orn/Lys/Arg decarboxylase, C-terminal domain; Region: OKR_DC_1_C; pfam03711
335659010337	aspartate-alanine antiporter; Region: Asp_Ala_antiprt; TIGR03802
335659010338	Predicted Permease Membrane Region; Region: Asp-Al_Ex; pfam06826
335659010339	TrkA-C domain; Region: TrkA_C; pfam02080
335659010340	Predicted Permease Membrane Region; Region: Asp-Al_Ex; pfam06826
335659010341	aspartate-alanine antiporter; Region: Asp_Ala_antiprt; TIGR03802
335659010342	Predicted Permease Membrane Region; Region: Asp-Al_Ex; pfam06826
335659010343	TrkA-C domain; Region: TrkA_C; pfam02080
335659010344	TrkA-C domain; Region: TrkA_C; pfam02080
335659010345	Predicted Permease Membrane Region; Region: Asp-Al_Ex; pfam06826
335659010346	aspartate 4-decarboxylase; Region: asp_4_decarbox; TIGR03801
335659010347	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
335659010348	pyridoxal 5'-phosphate binding site [chemical binding]; other site
335659010349	homodimer interface [polypeptide binding]; other site
335659010350	catalytic residue [active]
335659010351	polyphosphate kinase 2, PA0141 family; Region: PPK2_P_aer; TIGR03707
335659010352	Protein of unknown function (DUF3302); Region: DUF3302; pfam11742
335659010353	Multidrug resistance efflux pump [Defense mechanisms]; Region: EmrA; COG1566
335659010354	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
335659010355	Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011
335659010356	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
335659010357	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
335659010358	dimer interface [polypeptide binding]; other site
335659010359	phosphorylation site [posttranslational modification]
335659010360	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
335659010361	ATP binding site [chemical binding]; other site
335659010362	G-X-G motif; other site
335659010363	Protein of unknown function (DUF3300); Region: DUF3300; pfam11737
335659010364	Chaperone of endosialidase; Region: Peptidase_S74; pfam13884
335659010365	Protein of unknown function (DUF2950); Region: DUF2950; pfam11453
335659010366	Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea.  CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458
335659010367	DNA-binding site [nucleotide binding]; DNA binding site
335659010368	RNA-binding motif; other site
335659010369	Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340
335659010370	Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586
335659010371	Protein of unknown function (DUF2786); Region: DUF2786; pfam10979
335659010372	Domain of unknown function (DUF1476); Region: DUF1476; pfam07345
335659010373	hypothetical protein; Provisional; Region: PRK05208
335659010374	Lipoproteins [Cell envelope biogenesis, outer membrane]; Region: RlpA; COG0797
335659010375	Rare lipoprotein A (RlpA)-like double-psi beta-barrel; Region: DPBB_1; pfam03330
335659010376	Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596
335659010377	Putative lysophospholipase; Region: Hydrolase_4; pfam12146
335659010378	D-alanyl-D-alanine carboxypeptidase [Cell envelope biogenesis, outer membrane]; Region: DacC; COG1686
335659010379	Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872
335659010380	Penicillin-binding protein 5, C-terminal domain; Region: PBP5_C; pfam07943
335659010381	thymidylate kinase; Validated; Region: tmk; PRK00698
335659010382	Thymidine monophosphate kinase (TMPK), also known as thymidylate kinase, catalyzes the phosphorylation of thymidine monophosphate (TMP) to thymidine diphosphate (TDP) utilizing ATP as its preferred phophoryl donor. TMPK represents the rate-limiting step...; Region: TMPK; cd01672
335659010383	TMP-binding site; other site
335659010384	ATP-binding site [chemical binding]; other site
335659010385	DNA polymerase III subunit delta'; Validated; Region: PRK07471
335659010386	DNA polymerase III subunit delta'; Validated; Region: PRK08485
335659010387	methionyl-tRNA synthetase; Reviewed; Region: PRK11893
335659010388	catalytic core domain of methioninyl-tRNA synthetases; Region: MetRS_core; cd00814
335659010389	active site
335659010390	HIGH motif; other site
335659010391	KMSKS motif; other site
335659010392	Anticodon-binding domain of methionyl tRNA synthetases; Region: Anticodon_Ia_Met; cd07957
335659010393	tRNA binding surface [nucleotide binding]; other site
335659010394	anticodon binding site; other site
335659010395	Predicted metal-dependent hydrolases with the TIM-barrel fold [General function prediction only]; Region: COG1099
335659010396	TatD like proteins;  E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310
335659010397	active site
335659010398	Metal-dependent hydrolases of the beta-lactamase superfamily I [General function prediction only]; Region: PhnP; COG1235
335659010399	putative hydrolase; Provisional; Region: PRK02113
335659010400	Tripartite ATP-independent periplasmic transporters, DctQ component; Region: DctQ; pfam04290
335659010401	TRAP-type C4-dicarboxylate transport system, large permease component [Carbohydrate transport and metabolism]; Region: DctQ; cl17274
335659010402	DctM-like transporters; Region: DctM; pfam06808
335659010403	TRAP-type C4-dicarboxylate transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: DctP; COG1638
335659010404	Bacterial extracellular solute-binding protein, family 7; Region: SBP_bac_7; cl15441
335659010405	acyl-CoA synthetase; Validated; Region: PRK08162
335659010406	Fatty acyl-CoA synthetases similar to LC-FACS from Thermus thermophiles and Arabidopsis; Region: ttLC_FACS_AEE21_like; cd12118
335659010407	acyl-activating enzyme (AAE) consensus motif; other site
335659010408	putative active site [active]
335659010409	AMP binding site [chemical binding]; other site
335659010410	putative CoA binding site [chemical binding]; other site
335659010411	TRAP-type C4-dicarboxylate transport system, small permease component [Carbohydrate transport and metabolism]; Region: DctM; COG3090
335659010412	DctM-like transporters; Region: DctM; pfam06808
335659010413	TRAP-type C4-dicarboxylate transport system, large permease component [Carbohydrate transport and metabolism]; Region: DctQ; COG1593
335659010414	TRAP-type C4-dicarboxylate transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: DctP; COG1638
335659010415	Bacterial extracellular solute-binding protein, family 7; Region: SBP_bac_7; pfam03480
335659010416	Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cl10459
335659010417	Domain of unknown function (DUF1998); Region: DUF1998; pfam09369
335659010418	Helicase conserved C-terminal domain; Region: Helicase_C; pfam00271
335659010419	ATP-binding site [chemical binding]; other site
335659010420	O-succinylhomoserine sulfhydrylase; Validated; Region: PRK08133
335659010421	Bacterial transcriptional activator domain; Region: BTAD; smart01043
335659010422	Putative MetA-pathway of phenol degradation; Region: Phenol_MetA_deg; cl01768
335659010423	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
335659010424	HlyD family secretion protein; Region: HlyD_3; pfam13437
335659010425	Protein of unknown function (DUF3302); Region: DUF3302; pfam11742
335659010426	Protein of unknown function (DUF1254); Region: DUF1254; pfam06863
335659010427	Uncharacterized conserved protein [Function unknown]; Region: COG5361
335659010428	Protein of unknown function (DUF1214); Region: DUF1214; pfam06742
335659010429	Uncharacterized conserved protein [Function unknown]; Region: COG5361
335659010430	Protein of unknown function (DUF1254); Region: DUF1254; pfam06863
335659010431	Protein of unknown function (DUF1214); Region: DUF1214; pfam06742
335659010432	haloacid dehalogenase-like hydrolase; Region: Hydrolase; pfam00702
335659010433	haloacid dehalogenase-like hydrolase; Region: HAD; cl17202
335659010434	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
335659010435	motif II; other site
335659010436	Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119
335659010437	Sulfatase; Region: Sulfatase; pfam00884
335659010438	Uncharacterized conserved protein [Function unknown]; Region: COG1262
335659010439	Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; pfam03781
335659010440	Helix-turn-helix domain; Region: HTH_18; pfam12833
335659010441	phosphoenolpyruvate synthase; Validated; Region: PRK06464
335659010442	Pyruvate phosphate dikinase, PEP/pyruvate binding domain; Region: PPDK_N; pfam01326
335659010443	PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391
335659010444	PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896
335659010445	Fructose-1-phosphate kinase and related fructose-6-phosphate kinase (PfkB) [Carbohydrate transport and metabolism]; Region: FruK; COG1105
335659010446	1-phosphofructokinase (FruK), minor 6-phosphofructokinase (pfkB) and related sugar kinases. FruK plays an important role in the predominant pathway for fructose utilisation.This group also contains tagatose-6-phophate kinase, an enzyme of the tagatose...; Region: FruK_PfkB_like; cd01164
335659010447	putative substrate binding site [chemical binding]; other site
335659010448	putative ATP binding site [chemical binding]; other site
335659010449	ABC transporter transmembrane region 2; Region: ABC_membrane_2; cl00549
335659010450	Bacillus subtilis YkuE and related proteins, C-terminal metallophosphatase domain; Region: MPP_YkuE_C; cd07385
335659010451	Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149
335659010452	putative active site [active]
335659010453	putative metal binding site [ion binding]; other site
335659010454	Putative integral membrane protein DUF46; Region: DUF46; cl17511
335659010455	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
335659010456	Ligand Binding Site [chemical binding]; other site
335659010457	Universal stress protein family; Region: Usp; pfam00582
335659010458	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
335659010459	Ligand Binding Site [chemical binding]; other site
335659010460	putative FAD-binding dehydrogenase; Reviewed; Region: PRK12843
335659010461	putative FAD-binding dehydrogenase; Reviewed; Region: PRK12834
335659010462	Dehydroquinase (DHQase), type II. Dehydroquinase (or 3-dehydroquinate dehydratase) catalyzes the reversible dehydration of 3-dehydroquinate to form 3-dehydroshikimate. This reaction is part of two metabolic pathways: the biosynthetic shikimate pathway...; Region: DHQase_II; cd00466
335659010463	Dehydroquinase class II; Region: DHquinase_II; pfam01220
335659010464	trimer interface [polypeptide binding]; other site
335659010465	active site
335659010466	dimer interface [polypeptide binding]; other site
335659010467	TRAP-type C4-dicarboxylate transport system, large permease component [Carbohydrate transport and metabolism]; Region: DctQ; cl17274
335659010468	DctM-like transporters; Region: DctM; pfam06808
335659010469	TRAP-type C4-dicarboxylate transport system, small permease component [Carbohydrate transport and metabolism]; Region: DctM; COG3090
335659010470	TRAP-type C4-dicarboxylate transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: DctP; COG1638
335659010471	Bacterial extracellular solute-binding protein, family 7; Region: SBP_bac_7; pfam03480
335659010472	Transcriptional regulators [Transcription]; Region: GntR; COG1802
335659010473	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
335659010474	DNA-binding site [nucleotide binding]; DNA binding site
335659010475	FCD domain; Region: FCD; pfam07729
335659010476	Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006
335659010477	Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321
335659010478	A family including aminopeptidase P, aminopeptidase M, and prolidase. Also known as metallopeptidase family M24. This family of enzymes is able to cleave amido-, imido- and amidino-containing bonds. Members exibit relatively narrow substrate specificity...; Region: APP_MetAP; cd01066
335659010479	active site
335659010480	SMP-30/Gluconolaconase/LRE-like region; Region: SGL; pfam08450
335659010481	BA14K-like protein; Region: BA14K; pfam07886
335659010482	Uncharacterized iron-regulated membrane protein [Function unknown]; Region: PiuB; COG3182
335659010483	PepSY-associated TM helix; Region: PepSY_TM_3; pfam13706
335659010484	PepSY-associated TM helix; Region: PepSY_TM_2; pfam13703
335659010485	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
335659010486	FOG: CBS domain [General function prediction only]; Region: COG0517
335659010487	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the BON (bacterial OsmY and nodulation domain) domain. BON is a putative phospholipid-binding domain found in a family of osmotic shock protection...; Region: CBS_pair_BON_assoc; cd04586
335659010488	BON domain; Region: BON; pfam04972
335659010489	Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010
335659010490	Cytochrome c; Region: Cytochrom_C; pfam00034
335659010491	tyramine oxidase; Provisional; Region: tynA; PRK11504
335659010492	Copper amine oxidase, N2 domain; Region: Cu_amine_oxidN2; pfam02727
335659010493	Copper amine oxidase, N3 domain; Region: Cu_amine_oxidN3; pfam02728
335659010494	Copper amine oxidase, enzyme domain; Region: Cu_amine_oxid; pfam01179
335659010495	Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680
335659010496	Beta-lactamase; Region: Beta-lactamase; pfam00144
335659010497	Helix-turn-helix domain; Region: HTH_18; pfam12833
335659010498	NLPA lipoprotein; Region: Lipoprotein_9; pfam03180
335659010499	ABC-type metal ion transport system, periplasmic component/surface antigen [Inorganic ion transport and metabolism]; Region: NlpA; COG1464
335659010500	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
335659010501	dimer interface [polypeptide binding]; other site
335659010502	conserved gate region; other site
335659010503	ABC-ATPase subunit interface; other site
335659010504	DL-methionine transporter ATP-binding subunit; Provisional; Region: metN; PRK11153
335659010505	ATP-binding cassette domain of methionine transporter; Region: ABC_MetN_methionine_transporter; cd03258
335659010506	Walker A/P-loop; other site
335659010507	ATP binding site [chemical binding]; other site
335659010508	Q-loop/lid; other site
335659010509	ABC transporter signature motif; other site
335659010510	Walker B; other site
335659010511	D-loop; other site
335659010512	H-loop/switch region; other site
335659010513	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097
335659010514	This domain is found at the C-terminus of ABC transporter proteins involved in D-methionine transport as well as a number of ferredoxin-like proteins; Region: NIL; smart00930
335659010515	Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024
335659010516	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
335659010517	substrate binding site [chemical binding]; other site
335659010518	oxyanion hole (OAH) forming residues; other site
335659010519	trimer interface [polypeptide binding]; other site
335659010520	Nitrile hydratase, alpha chain; Region: NHase_alpha; pfam02979
335659010521	NHLP leader peptide domain; Region: TOMM_pelo; TIGR03793
335659010522	NHLP leader peptide domain; Region: TOMM_pelo; TIGR03793
335659010523	Nitrile hydratase beta subunit; Region: NHase_beta; pfam02211
335659010524	nitrile hydratase, beta subunit; Region: nitrile_beta; TIGR03888
335659010525	nitrile hydratase accessory protein; Region: nitrile_acc; TIGR03889
335659010526	ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120
335659010527	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
335659010528	Walker A/P-loop; other site
335659010529	ATP binding site [chemical binding]; other site
335659010530	Q-loop/lid; other site
335659010531	ABC transporter signature motif; other site
335659010532	Walker B; other site
335659010533	D-loop; other site
335659010534	H-loop/switch region; other site
335659010535	iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577
335659010536	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550
335659010537	ABC-ATPase subunit  interface; other site
335659010538	dimer interface [polypeptide binding]; other site
335659010539	putative PBP binding regions; other site
335659010540	ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614
335659010541	Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+.  Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262
335659010542	intersubunit interface [polypeptide binding]; other site
335659010543	TonB-dependent hemoglobin/transferrin/lactoferrin receptor family protein; Region: TonB-hemlactrns; TIGR01786
335659010544	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
335659010545	N-terminal plug; other site
335659010546	ligand-binding site [chemical binding]; other site
335659010547	ExsB is a transcription regulator related protein. It is a subfamily of a Adenosine nucleotide binding superfamily of proteins. This protein family is represented by a single member in nearly every completed large (> 1000 genes) prokaryotic genome. In...; Region: ExsB; cd01995
335659010548	Ligand Binding Site [chemical binding]; other site
335659010549	nucleoside triphosphate pyrophosphohydrolase; Reviewed; Region: mazG; PRK09562
335659010550	Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) N-terminal tandem-domain of MazG proteins from Escherichia coli and bacterial homologs; Region: NTP-PPase_MazG_Nterm; cd11528
335659010551	homodimer interface [polypeptide binding]; other site
335659010552	metal binding site [ion binding]; metal-binding site
335659010553	Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) C-terminal tandem-domain of MazG proteins from Escherichia coli and bacterial homologs' Region: NTP-PPase_MazG_Cterm; cd11529
335659010554	homodimer interface [polypeptide binding]; other site
335659010555	active site
335659010556	putative chemical substrate binding site [chemical binding]; other site
335659010557	metal binding site [ion binding]; metal-binding site
335659010558	GTP-binding protein HflX; Region: GTP_HflX; TIGR03156
335659010559	GTP-binding GTPase N-terminal; Region: GTP-bdg_N; pfam13167
335659010560	HflX GTPase family; Region: HflX; cd01878
335659010561	G1 box; other site
335659010562	GTP/Mg2+ binding site [chemical binding]; other site
335659010563	Switch I region; other site
335659010564	G2 box; other site
335659010565	G3 box; other site
335659010566	Switch II region; other site
335659010567	G4 box; other site
335659010568	G5 box; other site
335659010569	bacterial Hfq-like; Region: Hfq; cd01716
335659010570	hexamer interface [polypeptide binding]; other site
335659010571	Sm1 motif; other site
335659010572	RNA binding site [nucleotide binding]; other site
335659010573	Sm2 motif; other site
335659010574	Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204
335659010575	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
335659010576	active site
335659010577	phosphorylation site [posttranslational modification]
335659010578	intermolecular recognition site; other site
335659010579	dimerization interface [polypeptide binding]; other site
335659010580	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
335659010581	Walker A motif; other site
335659010582	ATP binding site [chemical binding]; other site
335659010583	Walker B motif; other site
335659010584	arginine finger; other site
335659010585	Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954
335659010586	Signal transduction histidine kinase involved in nitrogen fixation and metabolism regulation [Signal transduction mechanisms]; Region: NtrY; COG5000
335659010587	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
335659010588	dimerization interface [polypeptide binding]; other site
335659010589	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
335659010590	putative active site [active]
335659010591	heme pocket [chemical binding]; other site
335659010592	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
335659010593	dimer interface [polypeptide binding]; other site
335659010594	phosphorylation site [posttranslational modification]
335659010595	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
335659010596	ATP binding site [chemical binding]; other site
335659010597	Mg2+ binding site [ion binding]; other site
335659010598	G-X-G motif; other site
335659010599	nitrogen regulation protein NR(I); Region: ntrC; TIGR01818
335659010600	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
335659010601	active site
335659010602	phosphorylation site [posttranslational modification]
335659010603	intermolecular recognition site; other site
335659010604	dimerization interface [polypeptide binding]; other site
335659010605	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
335659010606	Walker A motif; other site
335659010607	ATP binding site [chemical binding]; other site
335659010608	Walker B motif; other site
335659010609	Bacterial regulatory protein, Fis family; Region: HTH_8; cl17420
335659010610	Signal transduction histidine kinase, nitrogen specific [Signal transduction mechanisms]; Region: NtrB; COG3852
335659010611	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
335659010612	putative active site [active]
335659010613	heme pocket [chemical binding]; other site
335659010614	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
335659010615	dimer interface [polypeptide binding]; other site
335659010616	phosphorylation site [posttranslational modification]
335659010617	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
335659010618	ATP binding site [chemical binding]; other site
335659010619	Mg2+ binding site [ion binding]; other site
335659010620	G-X-G motif; other site
335659010621	putative TIM-barrel protein, nifR3 family; Region: nifR3_yhdG; TIGR00737
335659010622	Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801
335659010623	FMN binding site [chemical binding]; other site
335659010624	active site
335659010625	catalytic residues [active]
335659010626	substrate binding site [chemical binding]; other site
335659010627	bifunctional 2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase/2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase protein; Provisional; Region: ispDF; PRK09382
335659010628	CDP-ME synthetase is involved in mevalonate-independent isoprenoid production; Region: CDP-ME_synthetase; cd02516
335659010629	substrate binding site; other site
335659010630	dimer interface; other site
335659010631	MECDP_synthase (2-C-methyl-D-erythritol-2,4-cyclodiphosphate synthase), encoded by the ispF gene, catalyzes the formation of 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (MEC) in the non-mevalonate deoxyxylulose (DOXP) pathway for isoprenoid biosynthesis; Region: MECDP_synthase; cd00554
335659010632	homotrimer interaction site [polypeptide binding]; other site
335659010633	zinc binding site [ion binding]; other site
335659010634	CDP-binding sites; other site
335659010635	Competence-damaged protein; Region: CinA; pfam02464
335659010636	Cytochrome c; Region: Cytochrom_C; cl11414
335659010637	Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010
335659010638	Cytochrome c; Region: Cytochrom_C; cl11414
335659010639	Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010
335659010640	Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010
335659010641	Cytochrome c; Region: Cytochrom_C; pfam00034
335659010642	Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; pfam00116
335659010643	ba3-like heme-copper oxidase subunit I.  The ba3 family of heme-copper oxidases are transmembrane protein complexes in the respiratory chains of prokaryotes and some archaea which catalyze the reduction of O2 and simultaneously pump protons across the...; Region: ba3-like_Oxidase_I; cd01660
335659010644	Putative D-pathway homolog; other site
335659010645	Cytochrome C and Quinol oxidase polypeptide I; Region: COX1; pfam00115
335659010646	Low-spin heme binding site [chemical binding]; other site
335659010647	Subunit I/II interface [polypeptide binding]; other site
335659010648	Putative Q-pathway; other site
335659010649	Putative alternate electron transfer pathway; other site
335659010650	Putative water exit pathway; other site
335659010651	Binuclear center (active site) [active]
335659010652	Putative K-pathway homolog; other site
335659010653	Putative proton exit pathway; other site
335659010654	Subunit I/IIa interface [polypeptide binding]; other site
335659010655	Electron transfer pathway; other site
335659010656	Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010
335659010657	Cytochrome c553 [Energy production and conversion]; Region: COG2863
335659010658	Cytochrome c; Region: Cytochrom_C; cl11414
335659010659	Coenzyme Q-binding protein COQ10p and similar proteins; Region: COQ10p_like; cd07813
335659010660	putative coenzyme Q binding site [chemical binding]; other site
335659010661	lipoyl synthase; Provisional; Region: PRK05481
335659010662	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
335659010663	FeS/SAM binding site; other site
335659010664	Alkyladenine DNA glycosylase catalyzes the first step in base excision repair; Region: AAG; cd00540
335659010665	DNA binding site [nucleotide binding]
335659010666	active site
335659010667	valyl-tRNA synthetase; Reviewed; Region: valS; PRK05729
335659010668	catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817
335659010669	HIGH motif; other site
335659010670	Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603
335659010671	catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817
335659010672	active site
335659010673	KMSKS motif; other site
335659010674	Anticodon-binding domain of valyl tRNA synthetases; Region: Anticodon_Ia_Val; cd07962
335659010675	tRNA binding surface [nucleotide binding]; other site
335659010676	anticodon binding site; other site
335659010677	Valyl tRNA synthetase tRNA binding arm; Region: Val_tRNA-synt_C; pfam10458
335659010678	Protein of unknown function (DUF2497); Region: DUF2497; pfam10691
335659010679	type I secretion outer membrane protein, TolC family; Region: type_I_sec_TolC; TIGR01844
335659010680	Protein-L-isoaspartate carboxylmethyltransferase [Posttranslational modification, protein turnover, chaperones]; Region: Pcm; COG2518
335659010681	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
335659010682	S-adenosylmethionine binding site [chemical binding]; other site
335659010683	potential protein location (hypothetical protein S23_37120 [Bradyrhizobium sp. S23321]) that overlaps RNA (tRNA-N)
335659010684	YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448
335659010685	homotrimer interaction site [polypeptide binding]; other site
335659010686	putative active site [active]
335659010687	Predicted acetamidase/formamidase [Energy production and conversion]; Region: COG2421
335659010688	Predicted acetamidase/formamidase [Energy production and conversion]; Region: COG2421
335659010689	TRAM domain; Region: TRAM; cl01282
335659010690	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
335659010691	dimer interface [polypeptide binding]; other site
335659010692	conserved gate region; other site
335659010693	putative PBP binding loops; other site
335659010694	ABC-ATPase subunit interface; other site
335659010695	ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126
335659010696	ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262
335659010697	Walker A/P-loop; other site
335659010698	ATP binding site [chemical binding]; other site
335659010699	Q-loop/lid; other site
335659010700	ABC transporter signature motif; other site
335659010701	Walker B; other site
335659010702	D-loop; other site
335659010703	H-loop/switch region; other site
335659010704	Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497
335659010705	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
335659010706	substrate binding pocket [chemical binding]; other site
335659010707	membrane-bound complex binding site; other site
335659010708	hinge residues; other site
335659010709	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
335659010710	S-adenosylmethionine binding site [chemical binding]; other site
335659010711	ABC-type polysaccharide/polyol phosphate transport system, ATPase component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagH; COG1134
335659010712	ATP-binding cassette component of polysaccharide transport system; Region: ABC_KpsT_Wzt; cd03220
335659010713	Walker A/P-loop; other site
335659010714	ATP binding site [chemical binding]; other site
335659010715	Q-loop/lid; other site
335659010716	ABC transporter signature motif; other site
335659010717	Walker B; other site
335659010718	D-loop; other site
335659010719	H-loop/switch region; other site
335659010720	ABC-type polysaccharide/polyol phosphate export systems, permease component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagG; COG1682
335659010721	DTW domain; Region: DTW; cl01221
335659010722	multidrug efflux system subunit MdtC; Provisional; Region: PRK10614
335659010723	multidrug efflux system subunit MdtB; Provisional; Region: PRK10503
335659010724	RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730
335659010725	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
335659010726	HlyD family secretion protein; Region: HlyD_3; pfam13437
335659010727	efflux transporter, outer membrane factor (OMF) lipoprotein, NodT family; Region: outer_NodT; TIGR01845
335659010728	Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031
335659010729	CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561
335659010730	dimer interface [polypeptide binding]; other site
335659010731	pyridoxal 5'-phosphate binding site [chemical binding]; other site
335659010732	catalytic residue [active]
335659010733	ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126
335659010734	ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262
335659010735	Walker A/P-loop; other site
335659010736	ATP binding site [chemical binding]; other site
335659010737	Q-loop/lid; other site
335659010738	ABC transporter signature motif; other site
335659010739	Walker B; other site
335659010740	D-loop; other site
335659010741	H-loop/switch region; other site
335659010742	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
335659010743	dimer interface [polypeptide binding]; other site
335659010744	conserved gate region; other site
335659010745	putative PBP binding loops; other site
335659010746	ABC-ATPase subunit interface; other site
335659010747	ABC-type amino acid transport system, permease component [Amino acid transport and metabolism]; Region: BatB; COG4597
335659010748	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
335659010749	conserved gate region; other site
335659010750	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
335659010751	dimer interface [polypeptide binding]; other site
335659010752	ABC-ATPase subunit interface; other site
335659010753	putative PBP binding loops; other site
335659010754	lysine-arginine-ornithine-binding periplasmic protein; Region: 3A0103s03R; TIGR01096
335659010755	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
335659010756	substrate binding pocket [chemical binding]; other site
335659010757	membrane-bound complex binding site; other site
335659010758	hinge residues; other site
335659010759	cystathionine beta-lyase; Provisional; Region: PRK05967
335659010760	CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614
335659010761	homodimer interface [polypeptide binding]; other site
335659010762	substrate-cofactor binding pocket; other site
335659010763	pyridoxal 5'-phosphate binding site [chemical binding]; other site
335659010764	catalytic residue [active]
335659010765	Na+/phosphate symporter [Inorganic ion transport and metabolism]; Region: NptA; COG1283
335659010766	Na+/Pi-cotransporter; Region: Na_Pi_cotrans; pfam02690
335659010767	PhoU domain; Region: PhoU; pfam01895
335659010768	PhoU domain; Region: PhoU; pfam01895
335659010769	Lipid A Biosynthesis N-terminal domain; Region: LAB_N; cl01627
335659010770	DPM_DPG-synthase_like is a member of the Glycosyltransferase 2 superfamily; Region: DPM_DPG-synthase_like; cd04179
335659010771	Putative Catalytic site; other site
335659010772	DXD motif; other site
335659010773	PAP2_like proteins, a super-family of histidine phosphatases and vanadium haloperoxidases, includes type 2 phosphatidic acid phosphatase or lipid phosphate phosphatase (LPP), Glucose-6-phosphatase, Phosphatidylglycerophosphatase B and bacterial acid...; Region: PAP2_like; cl00474
335659010774	active site
335659010775	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family [Cell envelope biogenesis, outer membrane]; Region: ArnT; COG1807
335659010776	penicillin-binding protein 1C; Region: PBP_1c; TIGR02073
335659010777	Transglycosylase; Region: Transgly; pfam00912
335659010778	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760
335659010779	Penicillin-Binding Protein C-terminus Family; Region: BiPBP_C; pfam06832
335659010780	Large extracellular alpha-helical protein [General function prediction only]; Region: COG2373
335659010781	MG2 domain; Region: A2M_N; pfam01835
335659010782	Alpha-2-macroglobulin family; Region: A2M; pfam00207
335659010783	Proteins similar to alpha2-macroglobulin (alpha (2)-M).  Alpha (2)-M is a major carrier protein in serum. It is a broadly specific proteinase inhibitor.  The structural thioester of alpha (2)-M, is involved in the immobilization and entrapment of...; Region: A2M_like; cd02891
335659010784	surface patch; other site
335659010785	thioester region; other site
335659010786	specificity defining residues; other site
335659010787	Fic/DOC family; Region: Fic; cl00960
335659010788	Conserved TM helix; Region: TM_helix; pfam05552
335659010789	Bacterial extracellular solute-binding protein, family 7; Region: SBP_bac_7; cl15441
335659010790	Tripartite ATP-independent periplasmic transporters, DctQ component; Region: DctQ; pfam04290
335659010791	DctM-like transporters; Region: DctM; pfam06808
335659010792	TRAP-type C4-dicarboxylate transport system, large permease component [Carbohydrate transport and metabolism]; Region: DctQ; COG1593
335659010793	Transcriptional regulators [Transcription]; Region: GntR; COG1802
335659010794	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
335659010795	DNA-binding site [nucleotide binding]; DNA binding site
335659010796	FCD domain; Region: FCD; pfam07729
335659010797	TRAP-type C4-dicarboxylate transport system, small permease component [Carbohydrate transport and metabolism]; Region: DctM; COG3090
335659010798	DctM-like transporters; Region: DctM; pfam06808
335659010799	TRAP-type C4-dicarboxylate transport system, large permease component [Carbohydrate transport and metabolism]; Region: DctQ; COG1593
335659010800	TRAP-type C4-dicarboxylate transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: DctP; COG1638
335659010801	Bacterial extracellular solute-binding protein, family 7; Region: SBP_bac_7; cl15441
335659010802	Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329
335659010803	Dihydrodipicolinate synthase family; Region: DHDPS-like; cd00408
335659010804	inhibitor site; inhibition site
335659010805	active site
335659010806	dimer interface [polypeptide binding]; other site
335659010807	catalytic residue [active]
335659010808	Isopropylmalate/homocitrate/citramalate synthases [Amino acid transport and metabolism]; Region: LeuA; COG0119
335659010809	3-hydroxy-3-methylglutaryl-CoA lyase, catalytic TIM barrel domain; Region: DRE_TIM_HMGL; cd07938
335659010810	active site
335659010811	catalytic residues [active]
335659010812	metal binding site [ion binding]; metal-binding site
335659010813	Acetyl/propionyl-CoA carboxylase, alpha subunit [Lipid metabolism]; Region: COG4770
335659010814	Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289
335659010815	Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786
335659010816	Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878
335659010817	The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850
335659010818	carboxyltransferase (CT) interaction site; other site
335659010819	biotinylation site [posttranslational modification]; other site
335659010820	3-methylcrotonyl-CoA carboxylase, beta chain; Region: PLN02820
335659010821	Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; cl17345
335659010822	Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; cl17345
335659010823	isovaleryl-CoA dehydrogenase; Region: PLN02519
335659010824	Isovaleryl-CoA dehydrogenase; Region: IVD; cd01156
335659010825	substrate binding site [chemical binding]; other site
335659010826	FAD binding site [chemical binding]; other site
335659010827	catalytic base [active]
335659010828	Arabinose-binding domain of AraC transcription regulator, N-term; Region: Arabinose_bd; pfam12625
335659010829	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
335659010830	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
335659010831	Protein of unknown function (DUF3551); Region: DUF3551; pfam12071
335659010832	Transcriptional regulators [Transcription]; Region: Lrp; COG1522
335659010833	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
335659010834	putative DNA binding site [nucleotide binding]; other site
335659010835	putative Zn2+ binding site [ion binding]; other site
335659010836	AsnC family; Region: AsnC_trans_reg; pfam01037
335659010837	ETC complex I subunit conserved region; Region: ETC_C1_NDUFA4; pfam04800
335659010838	OpgC protein; Region: OpgC_C; pfam10129
335659010839	Acyltransferase family; Region: Acyl_transf_3; pfam01757
335659010840	Uncharacterized ACR, COG1430; Region: DUF192; pfam02643
335659010841	Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea.  CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458
335659010842	DNA-binding site [nucleotide binding]; DNA binding site
335659010843	RNA-binding motif; other site
335659010844	Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea.  CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458
335659010845	DNA-binding site [nucleotide binding]; DNA binding site
335659010846	RNA-binding motif; other site
335659010847	NAD-dependent deacetylase; Provisional; Region: PRK00481
335659010848	SIRT7: Eukaryotic and prokaryotic group (class4) which includes human sirtuin SIRT6, SIRT7, and several bacterial homologs; and are members of the SIR2 family of proteins, silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent...; Region: SIRT7; cd01410
335659010849	NAD+ binding site [chemical binding]; other site
335659010850	substrate binding site [chemical binding]; other site
335659010851	Zn binding site [ion binding]; other site
335659010852	Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591
335659010853	IHF - DNA interface [nucleotide binding]; other site
335659010854	IHF dimer interface [polypeptide binding]; other site
335659010855	Protein of unknown function (DUF3606); Region: DUF3606; pfam12244
335659010856	Protein of unknown function (DUF2806); Region: DUF2806; cl12560
335659010857	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
335659010858	Glyoxalase I catalyzes the isomerization of the hemithioacetal, formed by a 2-oxoaldehyde and glutathione, to S-D-lactoylglutathione; Region: Glyoxalase_I; cd07233
335659010859	dimer interface [polypeptide binding]; other site
335659010860	active site
335659010861	metal binding site [ion binding]; metal-binding site
335659010862	glutathione binding site [chemical binding]; other site
335659010863	Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625
335659010864	GST_N family, unknown subfamily 2; composed of uncharacterized bacterial proteins with similarity to GSTs. GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of...; Region: GST_N_2; cd03047
335659010865	putative C-terminal domain interface [polypeptide binding]; other site
335659010866	putative GSH binding site (G-site) [chemical binding]; other site
335659010867	putative dimer interface [polypeptide binding]; other site
335659010868	C-terminal, alpha helical domain of an unknown subfamily 2 of Glutathione S-transferases; Region: GST_C_2; cd03180
335659010869	putative N-terminal domain interface [polypeptide binding]; other site
335659010870	putative dimer interface [polypeptide binding]; other site
335659010871	putative substrate binding pocket (H-site) [chemical binding]; other site
335659010872	PilZ domain; Region: PilZ; cl01260
335659010873	Uncharacterized ACR, COG2135; Region: DUF159; cl03646
335659010874	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173
335659010875	Domain of unknown function (DUF303); Region: DUF303; pfam03629
335659010876	Phage-related minor tail protein [Function unknown]; Region: COG5281
335659010877	Bacteriophage related domain of unknown function; Region: DUF4128; pfam13554
335659010878	phage conserved hypothetical protein, phiE125 gp8 family; Region: phage_chp_gp8; TIGR02215
335659010879	Head-Tail Connector Protein gp6 of Bacteriophage HK97 and similar proteins; Region: gp6; cd08054
335659010880	phage major capsid protein, HK97 family; Region: major_cap_HK97; TIGR01554
335659010881	Phage capsid family; Region: Phage_capsid; pfam05065
335659010882	Signal peptide peptidase A (SppA) 36K type, a serine protease, has catalytic Ser-Lys dyad; Region: S49_Sppa_36K_type; cd07022
335659010883	tandem repeat interface [polypeptide binding]; other site
335659010884	oligomer interface [polypeptide binding]; other site
335659010885	active site residues [active]
335659010886	Phage portal protein; Region: Phage_portal; pfam04860
335659010887	Phage-related protein [Function unknown]; Region: COG4695; cl01923
335659010888	Phage terminase-like protein, large subunit [General function prediction only]; Region: COG4626
335659010889	HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085
335659010890	active site
335659010891	suhB as predicted by Rfam v8.1 (RF00519), score 26.46
335659010892	N-Utilization Substance G (NusG) N-terminal (NGN) domain Superfamily; Region: NGN; cl02766
335659010893	NusG contains an NGN domain at its N-terminus and KOW motif at its C-terminus; Region: KOW_NusG; cd06091
335659010894	heterodimer interface [polypeptide binding]; other site
335659010895	homodimer interface [polypeptide binding]; other site
335659010896	Helix-turn-helix domain; Region: HTH_36; pfam13730
335659010897	Myb-like DNA-binding domain; Region: Myb_DNA-bind_6; pfam13921
335659010898	DNA binding site [nucleotide binding]
335659010899	HD domain; Region: HD_3; cl17350
335659010900	MT-A70; Region: MT-A70; cl01947
335659010901	Adenine nucleotide alpha hydrolases superfamily including N type ATP PPases, ATP sulphurylases Universal Stress Response protein and electron transfer flavoprotein (ETF). The domain forms a apha/beta/apha fold which  binds to Adenosine nucleotide; Region: AANH_like; cl00292
335659010902	Ligand Binding Site [chemical binding]; other site
335659010903	HNH endonuclease; Region: HNH_3; pfam13392
335659010904	hypothetical protein; Provisional; Region: PRK13694
335659010905	LexA DNA binding domain; Region: LexA_DNA_bind; pfam01726
335659010906	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
335659010907	non-specific DNA binding site [nucleotide binding]; other site
335659010908	salt bridge; other site
335659010909	sequence-specific DNA binding site [nucleotide binding]; other site
335659010910	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
335659010911	non-specific DNA binding site [nucleotide binding]; other site
335659010912	salt bridge; other site
335659010913	sequence-specific DNA binding site [nucleotide binding]; other site
335659010914	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
335659010915	active site
335659010916	Int/Topo IB signature motif; other site
335659010917	DNA binding site [nucleotide binding]
335659010918	PilZ domain; Region: PilZ; pfam07238
335659010919	The Delta9 Fatty Acid Desaturase (Delta9-FADS)-like CD includes the delta-9 and delta-11 acyl CoA desaturases found in various eukaryotes including vertebrates, insects, higher plants, and fungi. The delta-9 acyl-lipid desaturases are found in a wide...; Region: Delta9-FADS-like; cd03505
335659010920	Fatty acid desaturase; Region: FA_desaturase; pfam00487
335659010921	Di-iron ligands [ion binding]; other site
335659010922	Protease prsW family; Region: PrsW-protease; pfam13367
335659010923	Uncharacterized conserved protein [Function unknown]; Region: HdeD; COG3247
335659010924	phospho-2-dehydro-3-deoxyheptonate aldolase; Validated; Region: PRK09261
335659010925	DAHP synthetase I family; Region: DAHP_synth_1; pfam00793
335659010926	Lysine 2,3-aminomutase [Amino acid transport and metabolism]; Region: KamA; COG1509
335659010927	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
335659010928	FeS/SAM binding site; other site
335659010929	Lysine-2,3-aminomutase; Region: LAM_C; pfam12544
335659010930	Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA.   PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268
335659010931	EF-P lysine aminoacylase GenX; Region: genX; TIGR00462
335659010932	motif 1; other site
335659010933	dimer interface [polypeptide binding]; other site
335659010934	active site
335659010935	motif 2; other site
335659010936	motif 3; other site
335659010937	elongation factor P; Validated; Region: PRK00529
335659010938	Elongation factor P (EF-P) KOW-like domain; Region: EFP_N; pfam08207
335659010939	S1_EF-P_repeat_1: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_1; cd04470
335659010940	RNA binding site [nucleotide binding]; other site
335659010941	S1_EF-P_repeat_2: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_2; cd05794
335659010942	RNA binding site [nucleotide binding]; other site
335659010943	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2354
335659010944	Uncharacterized conserved protein, contains double-stranded beta-helix domain [Function unknown]; Region: COG1917
335659010945	Carboxymuconolactone decarboxylase family; Region: CMD; pfam02627
335659010946	Uncharacterized conserved protein [Function unknown]; Region: COG2128
335659010947	helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347
335659010948	MarR family; Region: MarR_2; pfam12802
335659010949	lytic murein transglycosylase; Region: MltB_2; TIGR02283
335659010950	Lytic Transglycosylase (LT)  and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL).  LTs...; Region: LT_GEWL; cd00254
335659010951	N-acetyl-D-glucosamine binding site [chemical binding]; other site
335659010952	Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471
335659010953	hypothetical protein; Provisional; Region: PRK06486
335659010954	intersubunit interface [polypeptide binding]; other site
335659010955	active site
335659010956	Zn2+ binding site [ion binding]; other site
335659010957	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
335659010958	3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653
335659010959	NAD(P) binding site [chemical binding]; other site
335659010960	active site
335659010961	single-stranded-DNA-specific exonuclease RecJ; Region: recJ; TIGR00644
335659010962	DHH family; Region: DHH; pfam01368
335659010963	DHHA1 domain; Region: DHHA1; pfam02272
335659010964	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
335659010965	dimer interface [polypeptide binding]; other site
335659010966	putative CheW interface [polypeptide binding]; other site
335659010967	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
335659010968	NADH(P)-binding; Region: NAD_binding_10; pfam13460
335659010969	NAD(P) binding site [chemical binding]; other site
335659010970	active site
335659010971	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
335659010972	Helix-turn-helix domain; Region: HTH_18; pfam12833
335659010973	Uncharacterized conserved protein [Function unknown]; Region: COG1262
335659010974	Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; pfam03781
335659010975	Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849
335659010976	The (Largely Gram-negative Bacterial) Hydrophobe/Amphiphile Efflux-1 (HAE1) Family; Region: 2A0602; TIGR00915
335659010977	Protein export membrane protein; Region: SecD_SecF; cl14618
335659010978	multidrug efflux system transporter AcrA; Provisional; Region: PRK15030
335659010979	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
335659010980	HlyD family secretion protein; Region: HlyD_3; pfam13437
335659010981	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
335659010982	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
335659010983	TOMM system kinase/cyclase fusion protein; Region: TOMM_kin_cyc; TIGR03903
335659010984	cyclase homology domain; Region: CHD; cd07302
335659010985	nucleotidyl binding site; other site
335659010986	metal binding site [ion binding]; metal-binding site
335659010987	dimer interface [polypeptide binding]; other site
335659010988	AAA ATPase domain; Region: AAA_16; pfam13191
335659010989	FAD-linked oxidoreductase; Region: bact_FAD_ox; TIGR01679
335659010990	FAD binding domain; Region: FAD_binding_4; pfam01565
335659010991	alpha-dioxygenase; Region: PLN02283
335659010992	Animal heme oxidases similar to plant pathogen-inducible oxygenases; Region: PIOX_like; cd09818
335659010993	putative heme binding site [chemical binding]; other site
335659010994	putative active site [active]
335659010995	putative substrate binding site [chemical binding]; other site
335659010996	2-haloalkanoic acid dehalogenase, type II; Region: HAD_type_II; TIGR01428
335659010997	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
335659010998	motif II; other site
335659010999	Bacterial fructose-1,6-bisphosphatase, glpX-encoded. A dimeric enzyme dependent on Mg(2+). glpX-encoded FPBase (FBPase class II) differs from other members of the inositol-phosphatase superfamily by permutation of secondary structure elements. The core...; Region: FBPase_glpX; cd01516
335659011000	Bacterial fructose-1,6-bisphosphatase, glpX-encoded; Region: FBPase_glpX; pfam03320
335659011001	putative active site [active]
335659011002	homoserine dehydrogenase; Provisional; Region: PRK06349
335659011003	Homoserine dehydrogenase, NAD binding domain; Region: NAD_binding_3; pfam03447
335659011004	Homoserine dehydrogenase; Region: Homoserine_dh; pfam00742
335659011005	ACT_HSDH_Hom CD includes the C-terminal ACT domain of the NAD(P)H-dependent, homoserine dehydrogenase (HSDH) and related domains; Region: ACT_HSDH-Hom; cd04881
335659011006	aminotransferase; Validated; Region: PRK09148
335659011007	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
335659011008	pyridoxal 5'-phosphate binding site [chemical binding]; other site
335659011009	homodimer interface [polypeptide binding]; other site
335659011010	catalytic residue [active]
335659011011	poly(R)-hydroxyalkanoic acid synthase, class I; Region: PHA_synth_I; TIGR01838
335659011012	Poly-beta-hydroxybutyrate polymerase (PhaC) N-terminus; Region: PhaC_N; pfam07167
335659011013	MAPEG family; Region: MAPEG; pfam01124
335659011014	Methyltransferase domain; Region: Methyltransf_23; pfam13489
335659011015	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
335659011016	S-adenosylmethionine binding site [chemical binding]; other site
335659011017	N-acetyl-gamma-glutamyl-phosphate reductase; Validated; Region: argC; PRK00436
335659011018	Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859
335659011019	N-acetyl-gamma-glutamyl-phosphate reductase; Provisional; Region: PRK11863
335659011020	Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859
335659011021	Putative FMN-binding domain; Region: FMN_bind_2; pfam04299
335659011022	Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586
335659011023	SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335
335659011024	DNA topoisomerase IV subunit B; Reviewed; Region: PRK05559
335659011025	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
335659011026	ATP binding site [chemical binding]; other site
335659011027	Mg2+ binding site [ion binding]; other site
335659011028	G-X-G motif; other site
335659011029	TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822
335659011030	anchoring element; other site
335659011031	dimer interface [polypeptide binding]; other site
335659011032	ATP binding site [chemical binding]; other site
335659011033	Topoisomerase-primase domain. This is a nucleotidyl transferase/hydrolase domain found in type IA, type IIA and type IIB topoisomerases, bacterial DnaG-type primases, small primase-like proteins from bacteria and archaea, OLD family nucleases from...; Region: TOPRIM; cl00718
335659011034	active site
335659011035	metal binding site [ion binding]; metal-binding site
335659011036	DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986
335659011037	Outer membrane protein beta-barrel domain; Region: OMP_b-brl; cl17254
335659011038	3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557
335659011039	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
335659011040	NAD(P) binding site [chemical binding]; other site
335659011041	active site
335659011042	Opacity protein and related surface antigens [Cell envelope biogenesis, outer membrane]; Region: COG3637
335659011043	hypothetical protein; Provisional; Region: PRK06185
335659011044	ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314
335659011045	Endomembrane protein 70; Region: EMP70; pfam02990
335659011046	Caspase domain; Region: Peptidase_C14; pfam00656
335659011047	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
335659011048	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
335659011049	DEAD-like helicases superfamily; Region: DEXDc; smart00487
335659011050	DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker  B motif; Region: DEADc; cd00268
335659011051	ATP binding site [chemical binding]; other site
335659011052	Mg++ binding site [ion binding]; other site
335659011053	motif III; other site
335659011054	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
335659011055	nucleotide binding region [chemical binding]; other site
335659011056	ATP-binding site [chemical binding]; other site
335659011057	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
335659011058	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
335659011059	metal binding site [ion binding]; metal-binding site
335659011060	active site
335659011061	I-site; other site
335659011062	FabA, beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase: Bacterial protein of the type II, fatty acid synthase system that binds ACP and catalyzes both dehydration and isomerization reactions, apparently in the same active site. The FabA...; Region: FabA; cd01287
335659011063	active site 1 [active]
335659011064	dimer interface [polypeptide binding]; other site
335659011065	active site 2 [active]
335659011066	TfoX N-terminal domain; Region: TfoX_N; pfam04993
335659011067	Fe-S cluster assembly scaffold protein [Posttranslational modification, protein turnover, chaperones]; Region: sufA; COG0316
335659011068	FeS assembly SUF system protein; Region: SUF_assoc; TIGR02945
335659011069	Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520
335659011070	Cysteine desulfurase (SufS)-like. This family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to cysteine desulfurase (SufS) and selenocysteine lyase. SufS...; Region: SufS_like; cd06453
335659011071	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
335659011072	catalytic residue [active]
335659011073	FeS assembly protein SufD; Region: sufD; TIGR01981
335659011074	Uncharacterized protein family (UPF0051); Region: UPF0051; pfam01458
335659011075	Cysteine desulfurase activator ATPase [Posttranslational modification, protein turnover, chaperones]; Region: sufC; COG0396
335659011076	ABC-type transport system involved in Fe-S cluster assembly, ATPase component; Region: ABC_FeS_Assembly; cd03217
335659011077	Walker A/P-loop; other site
335659011078	ATP binding site [chemical binding]; other site
335659011079	Q-loop/lid; other site
335659011080	ABC transporter signature motif; other site
335659011081	Walker B; other site
335659011082	D-loop; other site
335659011083	H-loop/switch region; other site
335659011084	cysteine desulfurase activator complex subunit SufB; Provisional; Region: PRK11814
335659011085	putative ABC transporter; Region: ycf24; CHL00085
335659011086	Cysteine sulfinate desulfinase/cysteine desulfurase and related enzymes [Amino acid transport and metabolism]; Region: NifS; COG1104
335659011087	cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402
335659011088	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
335659011089	catalytic residue [active]
335659011090	Predicted hydrolase of the alpha/beta superfamily [General function prediction only]; Region: COG2945
335659011091	Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388
335659011092	Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625
335659011093	C-terminal, alpha helical domain of the Glutathione S-transferase family; Region: GST_C_family; cd00299
335659011094	N-terminal domain interface [polypeptide binding]; other site
335659011095	dimer interface [polypeptide binding]; other site
335659011096	substrate binding pocket (H-site) [chemical binding]; other site
335659011097	anhydro-N-acetylmuramic acid kinase; Reviewed; Region: anmK; PRK09585
335659011098	tyrosyl-tRNA synthetase; Validated; Region: PRK05912
335659011099	catalytic core domain of tyrosinyl-tRNA synthetase; Region: TyrRS_core; cd00805
335659011100	active site
335659011101	HIGH motif; other site
335659011102	dimer interface [polypeptide binding]; other site
335659011103	KMSKS motif; other site
335659011104	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
335659011105	RNA binding surface [nucleotide binding]; other site
335659011106	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
335659011107	Major Facilitator Superfamily; Region: MFS_1; pfam07690
335659011108	putative substrate translocation pore; other site
335659011109	DoxX; Region: DoxX; pfam07681
335659011110	Cache is an extracellular domain that is predicted to have a role in small-molecule recognition in a wide range of proteins; Region: Cache_2; smart01049
335659011111	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054
335659011112	dimerization interface [polypeptide binding]; other site
335659011113	Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283
335659011114	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
335659011115	dimer interface [polypeptide binding]; other site
335659011116	putative CheW interface [polypeptide binding]; other site
335659011117	Protein of unknown function; Region: DUF3971; pfam13116
335659011118	AsmA-like C-terminal region; Region: AsmA_2; pfam13502
335659011119	Peroxiredoxin (PRX) family, Bacterioferritin comigratory protein (BCP) subfamily; composed of thioredoxin-dependent thiol peroxidases, widely expressed in pathogenic bacteria, that protect cells against toxicity from reactive oxygen species by reducing...; Region: PRX_BCP; cd03017
335659011120	Thioredoxin-like; Region: Thioredoxin_8; pfam13905
335659011121	catalytic triad [active]
335659011122	Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739
335659011123	Peptidase family M23; Region: Peptidase_M23; pfam01551
335659011124	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
335659011125	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
335659011126	type I secretion outer membrane protein, TolC family; Region: type_I_sec_TolC; TIGR01844
335659011127	RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730
335659011128	HlyD family secretion protein; Region: HlyD_3; pfam13437
335659011129	multidrug efflux protein; Reviewed; Region: PRK09579
335659011130	Catalase [Inorganic ion transport and metabolism]; Region: KatE; COG0753
335659011131	Catalase-like heme-binding proteins and protein domains; Region: catalase_like; cl09506
335659011132	heme binding pocket [chemical binding]; other site
335659011133	Type 1 glutamine amidotransferase (GATase1)-like domain found in at the C-terminal of several large catalases; Region: GATase1_catalase; cd03132
335659011134	domain interactions; other site
335659011135	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
335659011136	This family is most closely related to the GT1 family of glycosyltransferases. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can...; Region: GT1_like_4; cd03795
335659011137	putative ADP-binding pocket [chemical binding]; other site
335659011138	ABC-type polysaccharide/polyol phosphate export systems, permease component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagG; COG1682
335659011139	ABC-2 type transporter; Region: ABC2_membrane; pfam01061
335659011140	ABC-type polysaccharide/polyol phosphate transport system, ATPase component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagH; COG1134
335659011141	ATP-binding cassette component of polysaccharide transport system; Region: ABC_KpsT_Wzt; cd03220
335659011142	Walker A/P-loop; other site
335659011143	ATP binding site [chemical binding]; other site
335659011144	Q-loop/lid; other site
335659011145	ABC transporter signature motif; other site
335659011146	Walker B; other site
335659011147	D-loop; other site
335659011148	H-loop/switch region; other site
335659011149	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
335659011150	This family is most closely related to the GT1 family of glycosyltransferases. mtfB (mannosyltransferase B) in E. coli has been shown to direct the growth of the O9-specific polysaccharide chain. It transfers two mannoses into the position 3 of the...; Region: GT1_mtfB_like; cd03809
335659011151	O-Antigen ligase; Region: Wzy_C; pfam04932
335659011152	Type I periplasmic ligand-binding domain of uncharacterized ABC (ATPase Binding Cassette)-type active transport systems that are predicted to be involved in uptake of amino acids, peptides, or inorganic ions; Region: PBP1_ABC_ligand_binding_like_8; cd06343
335659011153	Periplasmic binding protein; Region: Peripla_BP_6; pfam13458
335659011154	putative ligand binding site [chemical binding]; other site
335659011155	Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697
335659011156	EamA-like transporter family; Region: EamA; pfam00892
335659011157	3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084
335659011158	6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599
335659011159	peptide chain release factor 2; Provisional; Region: PRK07342
335659011160	This domain is found in peptide chain release factors; Region: PCRF; smart00937
335659011161	RF-1 domain; Region: RF-1; pfam00472
335659011162	Membrane carboxypeptidase/penicillin-binding protein [Cell envelope biogenesis, outer membrane]; Region: MrcA; COG5009
335659011163	Transglycosylase; Region: Transgly; pfam00912
335659011164	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905
335659011165	AMIN domain; Region: AMIN; pfam11741
335659011166	N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860
335659011167	N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696
335659011168	active site
335659011169	metal binding site [ion binding]; metal-binding site
335659011170	S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927
335659011171	Ribonuclease E/G family; Region: RNase_E_G; pfam10150
335659011172	Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665
335659011173	hydroxyglutarate oxidase; Provisional; Region: PRK11728
335659011174	Tetratricopeptide repeat; Region: TPR_12; pfam13424
335659011175	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
335659011176	binding surface
335659011177	TPR motif; other site
335659011178	TPR repeat; Region: TPR_11; pfam13414
335659011179	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
335659011180	binding surface
335659011181	TPR motif; other site
335659011182	TPR repeat; Region: TPR_11; pfam13414
335659011183	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
335659011184	binding surface
335659011185	TPR motif; other site
335659011186	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
335659011187	salt bridge; other site
335659011188	non-specific DNA binding site [nucleotide binding]; other site
335659011189	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
335659011190	sequence-specific DNA binding site [nucleotide binding]; other site
335659011191	atypical (a) SDRs, subgroup 7; Region: SDR_a7; cd05262
335659011192	Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451
335659011193	putative NAD(P) binding site [chemical binding]; other site
335659011194	C4-dicarboxylate transporter DctA; Reviewed; Region: PRK01663
335659011195	Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301
335659011196	BioY family; Region: BioY; pfam02632
335659011197	aspartate aminotransferase; Provisional; Region: PRK05764
335659011198	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
335659011199	pyridoxal 5'-phosphate binding site [chemical binding]; other site
335659011200	homodimer interface [polypeptide binding]; other site
335659011201	catalytic residue [active]
335659011202	Peptidase family M48; Region: Peptidase_M48; cl12018
335659011203	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
335659011204	Tetratricopeptide repeat; Region: TPR_16; pfam13432
335659011205	binding surface
335659011206	TPR motif; other site
335659011207	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
335659011208	TPR motif; other site
335659011209	binding surface
335659011210	DsbA family, Com1-like subfamily; composed of proteins similar to Com1, a 27-kDa outer membrane-associated immunoreactive protein originally found in both acute and chronic disease strains of the pathogenic bacteria Coxiella burnetti. It contains a CXXC...; Region: DsbA_Com1_like; cd03023
335659011211	DSBA-like thioredoxin domain; Region: DSBA; pfam01323
335659011212	catalytic residues [active]
335659011213	Protein of unknown function (DUF1236); Region: DUF1236; pfam06823
335659011214	Dehydroquinase (DHQase), type II. Dehydroquinase (or 3-dehydroquinate dehydratase) catalyzes the reversible dehydration of 3-dehydroquinate to form 3-dehydroshikimate. This reaction is part of two metabolic pathways: the biosynthetic shikimate pathway...; Region: DHQase_II; cd00466
335659011215	Dehydroquinase class II; Region: DHquinase_II; pfam01220
335659011216	trimer interface [polypeptide binding]; other site
335659011217	active site
335659011218	dimer interface [polypeptide binding]; other site
335659011219	acetyl-CoA carboxylase biotin carboxyl carrier protein subunit; Validated; Region: PRK06302
335659011220	The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850
335659011221	carboxyltransferase (CT) interaction site; other site
335659011222	biotinylation site [posttranslational modification]; other site
335659011223	acetyl-CoA carboxylase biotin carboxylase subunit; Validated; Region: PRK08591
335659011224	Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289
335659011225	ATP-grasp domain; Region: ATP-grasp_4; cl17255
335659011226	Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878
335659011227	CHASE3 domain; Region: CHASE3; pfam05227
335659011228	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
335659011229	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cl00080
335659011230	dimer interface [polypeptide binding]; other site
335659011231	phosphorylation site [posttranslational modification]
335659011232	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
335659011233	ATP binding site [chemical binding]; other site
335659011234	Mg2+ binding site [ion binding]; other site
335659011235	G-X-G motif; other site
335659011236	FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784
335659011237	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
335659011238	active site
335659011239	phosphorylation site [posttranslational modification]
335659011240	intermolecular recognition site; other site
335659011241	dimerization interface [polypeptide binding]; other site
335659011242	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
335659011243	Response regulator receiver domain; Region: Response_reg; pfam00072
335659011244	active site
335659011245	phosphorylation site [posttranslational modification]
335659011246	intermolecular recognition site; other site
335659011247	dimerization interface [polypeptide binding]; other site
335659011248	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920
335659011249	Histidine kinase; Region: HisKA_2; pfam07568
335659011250	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
335659011251	ATP binding site [chemical binding]; other site
335659011252	Mg2+ binding site [ion binding]; other site
335659011253	G-X-G motif; other site
335659011254	leucyl/phenylalanyl-tRNA--protein transferase; Reviewed; Region: aat; PRK00301
335659011255	Uncharacterized protein conserved in bacteria (DUF2155); Region: DUF2155; pfam09923
335659011256	Esterases and lipases (includes fungal lipases, cholinesterases, etc.)  These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312
335659011257	alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859
335659011258	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
335659011259	S-adenosylmethionine binding site [chemical binding]; other site
335659011260	Helix-turn-helix domain; Region: HTH_18; pfam12833
335659011261	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
335659011262	Transcriptional regulator containing an amidase domain and an AraC-type DNA-binding HTH domain [Transcription]; Region: COG4977
335659011263	AraC transcriptional regulators having a Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GATase1_AraC_1; cd03137
335659011264	conserved cys residue [active]
335659011265	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
335659011266	Putative intracellular protease/amidase [General function prediction only]; Region: ThiJ; COG0693
335659011267	Type 1 glutamine amidotransferase (GATase1)-like domain found in a subgroup of proteins similar to PfpI from Pyrococcus furiosus; Region: GATase1_PfpI_2; cd03139
335659011268	conserved cys residue [active]
335659011269	NADH dehydrogenase; Validated; Region: PRK08183
335659011270	BA14K-like protein; Region: BA14K; pfam07886
335659011271	Response regulator receiver domain; Region: Response_reg; pfam00072
335659011272	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
335659011273	active site
335659011274	phosphorylation site [posttranslational modification]
335659011275	intermolecular recognition site; other site
335659011276	dimerization interface [polypeptide binding]; other site
335659011277	CHASE3 domain; Region: CHASE3; pfam05227
335659011278	Signal transduction histidine kinase, nitrogen specific [Signal transduction mechanisms]; Region: NtrB; COG3852
335659011279	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
335659011280	putative active site [active]
335659011281	heme pocket [chemical binding]; other site
335659011282	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
335659011283	dimer interface [polypeptide binding]; other site
335659011284	phosphorylation site [posttranslational modification]
335659011285	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
335659011286	ATP binding site [chemical binding]; other site
335659011287	Mg2+ binding site [ion binding]; other site
335659011288	G-X-G motif; other site
335659011289	Response regulator receiver domain; Region: Response_reg; pfam00072
335659011290	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
335659011291	active site
335659011292	phosphorylation site [posttranslational modification]
335659011293	intermolecular recognition site; other site
335659011294	dimerization interface [polypeptide binding]; other site
335659011295	EamA-like transporter family; Region: EamA; pfam00892
335659011296	EamA-like transporter family; Region: EamA; pfam00892
335659011297	ribonucleotide-diphosphate reductase subunit alpha; Validated; Region: PRK07562
335659011298	Class II vitamin B12-dependent ribonucleotide reductase; Region: Ribonuc_red_2_N; pfam08471
335659011299	Ribonucleotide reductase and Pyruvate formate lyase; Region: RNR_PFL; cl09939
335659011300	Class II ribonucleotide reductase, dimeric form; Region: RNR_II_dimer; cd02888
335659011301	active site
335659011302	Ribonucleotide reductase and Pyruvate formate lyase; Region: RNR_PFL; cl09939
335659011303	TSCPD domain; Region: TSCPD; pfam12637
335659011304	Endodeoxyribonuclease RusA; Region: RusA; cl01885
335659011305	ParB-like nuclease domain; Region: ParB; smart00470
335659011306	This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587
335659011307	active site
335659011308	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
335659011309	Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_oxidase; pfam01243
335659011310	Tripartite tricarboxylate transporter family receptor; Region: TctC; cl17792
335659011311	Predicted ornithine cyclodeaminase, mu-crystallin homolog [Amino acid transport and metabolism]; Region: COG2423
335659011312	ornithine cyclodeaminase; Validated; Region: PRK06823; cl17400
335659011313	galactosyl transferase GMA12/MNN10 family; Region: Glyco_transf_34; cl05288
335659011314	Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285
335659011315	nucleoside/Zn binding site; other site
335659011316	dimer interface [polypeptide binding]; other site
335659011317	catalytic motif [active]
335659011318	Mg2+ and Co2+ transporters [Inorganic ion transport and metabolism]; Region: CorA; COG0598
335659011319	Mycobacterium tuberculosis CorA-like subfamily; Region: MtCorA-like; cd12830
335659011320	oligomer interface [polypeptide binding]; other site
335659011321	metal binding site [ion binding]; metal-binding site
335659011322	metal binding site [ion binding]; metal-binding site
335659011323	putative Cl binding site [ion binding]; other site
335659011324	basic sphincter; other site
335659011325	hydrophobic gate; other site
335659011326	periplasmic entrance; other site
335659011327	Cytochrome c; Region: Cytochrom_C; pfam00034
335659011328	Uncharacterized Zn-ribbon-containing protein involved in phosphonate metabolism [Inorganic ion transport and metabolism]; Region: PhnA; COG2824
335659011329	PhnA Zinc-Ribbon; Region: PhnA_Zn_Ribbon; pfam08274
335659011330	PhnA protein; Region: PhnA; pfam03831
335659011331	pyridoxamine kinase; Validated; Region: PRK05756
335659011332	Pyridoxal kinase plays a key role in the synthesis of the active coenzyme pyridoxal-5'-phosphate  (PLP), by catalyzing the phosphorylation of the precursor vitamin B6  in the presence of Zn2+ and ATP. Mammals are unable to synthesize PLP de novo and...; Region: pyridoxal_pyridoxamine_kinase; cd01173
335659011333	pyridoxal binding site [chemical binding]; other site
335659011334	dimer interface [polypeptide binding]; other site
335659011335	ATP binding site [chemical binding]; other site
335659011336	Putative FMN-binding domain; Region: FMN_bind_2; cl17803
335659011337	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
335659011338	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
335659011339	Predicted O-methyltransferase [General function prediction only]; Region: COG4122
335659011340	Methyltransferase domain; Region: Methyltransf_24; pfam13578
335659011341	Membrane transporters of cations and cationic drugs [Inorganic ion transport and metabolism]; Region: EmrE; COG2076
335659011342	Protein of unknown function (DUF3551); Region: DUF3551; pfam12071
335659011343	phenol 2-monooxygenase; Provisional; Region: PRK08294
335659011344	Predicted oxidoreductase [General function prediction only]; Region: COG3573
335659011345	ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314
335659011346	FAD-dependent Phenol hydoxylase (PHOX) family, C-terminal TRX-fold domain; composed of proteins similar to PHOX from the aerobic topsoil yeast Trichosporon cutaneum. PHOX is a flavoprotein monooxygenase that catalyzes the hydroxylation of phenol and...; Region: PHOX_C; cd02979
335659011347	dimer interface [polypeptide binding]; other site
335659011348	helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347
335659011349	MarR family; Region: MarR; pfam01047
335659011350	MarR family; Region: MarR_2; cl17246
335659011351	Secreted repeat of unknown function; Region: Lipoprotein_15; pfam03640
335659011352	Secreted repeat of unknown function; Region: Lipoprotein_15; pfam03640
335659011353	Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376
335659011354	L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734
335659011355	DNA polymerase III subunits gamma and tau; Provisional; Region: PRK14960
335659011356	Myosin and Kinesin motor domain. These ATPases belong to the P-loop NTPase family and provide the driving force in myosin and kinesin mediated processes; Region: Motor_domain; cl00286
335659011357	3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK07231
335659011358	classical (c) SDRs; Region: SDR_c; cd05233
335659011359	NAD(P) binding site [chemical binding]; other site
335659011360	active site
335659011361	PAS domain S-box; Region: sensory_box; TIGR00229
335659011362	PAS fold; Region: PAS_4; pfam08448
335659011363	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
335659011364	dimer interface [polypeptide binding]; other site
335659011365	phosphorylation site [posttranslational modification]
335659011366	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
335659011367	ATP binding site [chemical binding]; other site
335659011368	Mg2+ binding site [ion binding]; other site
335659011369	G-X-G motif; other site
335659011370	FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784
335659011371	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
335659011372	active site
335659011373	phosphorylation site [posttranslational modification]
335659011374	intermolecular recognition site; other site
335659011375	dimerization interface [polypeptide binding]; other site
335659011376	cell division topological specificity factor MinE; Reviewed; Region: minE; PRK00296
335659011377	Septum formation inhibitor-activating ATPase [Cell division and chromosome partitioning]; Region: MinD; COG2894
335659011378	Bacterial cell division requires the formation of a septum at mid-cell. The site is determined by the min operon products MinC, MinD and MinE. MinC is a nonspecific inhibitor of the septum protein FtsZ. MinE is the supressor of MinC. MinD plays a pivotal...; Region: MinD; cd02036
335659011379	Switch I; other site
335659011380	Switch II; other site
335659011381	septum formation inhibitor; Reviewed; Region: minC; PRK05177
335659011382	Septum formation inhibitor MinC, N-terminal domain; Region: MinC_N; pfam05209
335659011383	Septum formation inhibitor MinC, C-terminal domain; Region: MinC_C; pfam03775
335659011384	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cl17432
335659011385	NMT1/THI5 like; Region: NMT1; pfam09084
335659011386	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
335659011387	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
335659011388	ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600
335659011389	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
335659011390	dimer interface [polypeptide binding]; other site
335659011391	conserved gate region; other site
335659011392	ABC-ATPase subunit interface; other site
335659011393	Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451
335659011394	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
335659011395	NAD(P) binding site [chemical binding]; other site
335659011396	active site
335659011397	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
335659011398	active site
335659011399	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
335659011400	Coenzyme A binding pocket [chemical binding]; other site
335659011401	Dihydrodipicolinate synthase family; Region: DHDPS-like; cd00408
335659011402	inhibitor site; inhibition site
335659011403	active site
335659011404	dimer interface [polypeptide binding]; other site
335659011405	catalytic residue [active]
335659011406	ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116
335659011407	ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293
335659011408	Walker A/P-loop; other site
335659011409	ATP binding site [chemical binding]; other site
335659011410	Q-loop/lid; other site
335659011411	ABC transporter signature motif; other site
335659011412	Walker B; other site
335659011413	D-loop; other site
335659011414	H-loop/switch region; other site
335659011415	Haemagglutinin; Region: HIM; pfam05662
335659011416	TRAP-type mannitol/chloroaromatic compound transport system, periplasmic component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: FcbT1; COG4663
335659011417	Bacterial extracellular solute-binding protein, family 7; Region: SBP_bac_7; cl15441
335659011418	Protein of unknown function (DUF2778); Region: DUF2778; pfam10908
335659011419	Protein of unknown function (DUF1810); Region: DUF1810; pfam08837
335659011420	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054
335659011421	Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283
335659011422	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
335659011423	dimer interface [polypeptide binding]; other site
335659011424	putative CheW interface [polypeptide binding]; other site
335659011425	Predicted flavoprotein [General function prediction only]; Region: COG0431
335659011426	NADPH-dependent FMN reductase; Region: FMN_red; pfam03358
335659011427	Helix-turn-helix domain; Region: HTH_18; pfam12833
335659011428	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
335659011429	Uncharacterized protein conserved in bacteria (DUF2336); Region: DUF2336; pfam10098
335659011430	PilZ domain; Region: PilZ; pfam07238
335659011431	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
335659011432	Zn2+ binding site [ion binding]; other site
335659011433	Mg2+ binding site [ion binding]; other site
335659011434	Nitroreductase family. Members of this family utilize FMN as a cofactor and catalyze reduction of a variety of nitroaromatic compounds, including nitrofurans, nitrobenzens, nitrophenol, nitrobenzoate and quinones by using either NADH or NADPH as a source...; Region: Nitroreductase; cd02136
335659011435	putative FMN binding site [chemical binding]; other site
335659011436	Esterases and lipases (includes fungal lipases, cholinesterases, etc.)  These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312
335659011437	alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859
335659011438	Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849
335659011439	ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488
335659011440	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
335659011441	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
335659011442	ABC transporter; Region: ABC_tran_2; pfam12848
335659011443	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
335659011444	Transcriptional regulator [Transcription]; Region: IclR; COG1414
335659011445	Bacterial transcriptional regulator; Region: IclR; pfam01614
335659011446	Predicted metal-dependent hydrolase of the TIM-barrel fold [General function prediction only]; Region: COG3618
335659011447	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
335659011448	active site
335659011449	Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804
335659011450	CoA-transferase family III; Region: CoA_transf_3; pfam02515
335659011451	NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902
335659011452	Old yellow enzyme (OYE) YqjM-like FMN binding domain. YqjM is involved in the oxidative stress response of Bacillus subtilis.  Like the other OYE members, each monomer of YqjM contains FMN as a non-covalently bound cofactor and uses NADPH as a reducing...; Region: OYE_YqiM_FMN; cd02932
335659011453	active site
335659011454	FMN binding site [chemical binding]; other site
335659011455	substrate binding site [chemical binding]; other site
335659011456	homotetramer interface [polypeptide binding]; other site
335659011457	catalytic residue [active]
335659011458	Periplasmic binding protein; Region: Peripla_BP_6; pfam13458
335659011459	Periplasmic solute-binding domain of active transport proteins that belong to the type I periplasmic binding fold protein family; Region: PBP1_SBP_like_1; cd06327
335659011460	putative ligand binding site [chemical binding]; other site
335659011461	FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790
335659011462	Sel1-like repeats; Region: SEL1; smart00671
335659011463	Sel1-like repeats; Region: SEL1; smart00671
335659011464	Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531
335659011465	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199
335659011466	glutamine synthetase; Region: PLN02284
335659011467	Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951
335659011468	Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120
335659011469	Protein of unknown function (DUF2735); Region: DUF2735; pfam10931
335659011470	Membrane-bound lysozyme-inhibitor of c-type lysozyme; Region: MliC; cl01604
335659011471	Tyrosine phosphatase family; Region: Y_phosphatase3; pfam13350
335659011472	Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr; Region: PTPc; cl00053
335659011473	Tyrosine phosphatase family C-terminal region; Region: Y_phosphatase3C; pfam13348
335659011474	SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cd00229
335659011475	active site
335659011476	oxyanion hole [active]
335659011477	short chain dehydrogenase; Provisional; Region: PRK12828
335659011478	dihydropteridine reductase (DHPR), classical (c) SDRs; Region: DHPR_SDR_c_like; cd05334
335659011479	NAD binding site [chemical binding]; other site
335659011480	homodimer interface [polypeptide binding]; other site
335659011481	active site
335659011482	Uncharacterized conserved protein (DUF2161); Region: DUF2161; cl02298
335659011483	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
335659011484	Coenzyme A binding pocket [chemical binding]; other site
335659011485	PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria.  Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443
335659011486	CoenzymeA binding site [chemical binding]; other site
335659011487	subunit interaction site [polypeptide binding]; other site
335659011488	PHB binding site; other site
335659011489	Cobalamin binding protein BtuF.  These proteins have been shown to function as initial receptors in ABC transport of vitamin B12 (cobalamin) in eubacterial and some archaeal species.  They belong to the TroA superfamily of helical backbone metal receptor...; Region: BtuF; cd01144
335659011490	Periplasmic binding protein; Region: Peripla_BP_2; pfam01497
335659011491	cobalamin binding residues [chemical binding]; other site
335659011492	putative BtuC binding residues; other site
335659011493	dimer interface [polypeptide binding]; other site
335659011494	kynureninase; Region: kynureninase; TIGR01814
335659011495	Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321
335659011496	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
335659011497	catalytic residue [active]
335659011498	tryptophan 2,3-dioxygenase; Region: trp_2_3_diox; TIGR03036
335659011499	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
335659011500	acetylornithine deacetylase; Provisional; Region: PRK06837
335659011501	M20 Peptidases with similarity to acetylornithine deacetylases and succinyl-diaminopimelate desuccinylases; Region: M20_ArgE_DapE_like2; cd03895
335659011502	metal binding site [ion binding]; metal-binding site
335659011503	dimer interface [polypeptide binding]; other site
335659011504	Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_ox_2; pfam12900
335659011505	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
335659011506	DNA-binding site [nucleotide binding]; DNA binding site
335659011507	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167
335659011508	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
335659011509	pyridoxal 5'-phosphate binding site [chemical binding]; other site
335659011510	homodimer interface [polypeptide binding]; other site
335659011511	catalytic residue [active]
335659011512	Uncharacterized protein conserved in bacteria [Function unknown]; Region: CreA; COG3045
335659011513	CreA protein; Region: CreA; pfam05981
335659011514	hypothetical protein; Provisional; Region: PRK06132
335659011515	L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734
335659011516	Glutathione (GSH) peroxidase family; tetrameric selenoenzymes that catalyze the reduction of a variety of hydroperoxides including lipid peroxidases, using GSH as a specific electron donor substrate. GSH peroxidase contains one selenocysteine residue per...; Region: GSH_Peroxidase; cd00340
335659011517	catalytic residues [active]
335659011518	dimer interface [polypeptide binding]; other site
335659011519	Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726
335659011520	Catalytic NodB homology domain of rhizobial NodB-like proteins; Region: CE4_NodB_like_6s_7s; cd10917
335659011521	NodB motif; other site
335659011522	active site
335659011523	catalytic site [active]
335659011524	metal binding site [ion binding]; metal-binding site
335659011525	Autotransporter beta-domain; Region: Autotransporter; smart00869
335659011526	DNA-binding transcriptional activator FeaR; Provisional; Region: PRK09685
335659011527	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
335659011528	Opacity protein and related surface antigens [Cell envelope biogenesis, outer membrane]; Region: COG3637
335659011529	Outer membrane protein beta-barrel domain; Region: OMP_b-brl; cl17254
335659011530	HR-like lesion-inducing; Region: HR_lesion; pfam05514
335659011531	bifunctional malic enzyme oxidoreductase/phosphotransacetylase; Reviewed; Region: PRK07232
335659011532	Malic enzyme, N-terminal domain; Region: malic; pfam00390
335659011533	NAD(P) binding domain of malic enzyme (ME), subgroup 2; Region: NAD_bind_2_malic_enz; cd05311
335659011534	putative NAD(P) binding site [chemical binding]; other site
335659011535	Phosphotransacetylase [Energy production and conversion]; Region: Pta; COG0280
335659011536	aspartyl-tRNA synthetase; Validated; Region: aspS; PRK00476
335659011537	EcAspRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli aspartyl-tRNA synthetase (AspRS), the human mitochondrial (mt) AspRS-2, the discriminating (D) Thermus thermophilus AspRS-1, and the nondiscriminating (ND)...; Region: EcAspRS_like_N; cd04317
335659011538	dimer interface [polypeptide binding]; other site
335659011539	anticodon binding site; other site
335659011540	Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of...; Region: AspRS_core; cd00777
335659011541	homodimer interface [polypeptide binding]; other site
335659011542	motif 1; other site
335659011543	active site
335659011544	motif 2; other site
335659011545	GAD domain; Region: GAD; pfam02938
335659011546	Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA.   PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268
335659011547	active site
335659011548	motif 3; other site
335659011549	hypothetical protein; Validated; Region: PRK00029
335659011550	Uncharacterized conserved protein [Function unknown]; Region: COG0397
335659011551	Predicted phosphohydrolases [General function prediction only]; Region: Icc; COG1409
335659011552	Enterobacter aerogenes GpdQ and related proteins, metallophosphatase domain; Region: MPP_GpdQ; cd07402
335659011553	active site
335659011554	metal binding site [ion binding]; metal-binding site
335659011555	hexamer interface [polypeptide binding]; other site
335659011556	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
335659011557	dimer interface [polypeptide binding]; other site
335659011558	conserved gate region; other site
335659011559	putative PBP binding loops; other site
335659011560	ABC-ATPase subunit interface; other site
335659011561	ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395
335659011562	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
335659011563	dimer interface [polypeptide binding]; other site
335659011564	conserved gate region; other site
335659011565	putative PBP binding loops; other site
335659011566	ABC-ATPase subunit interface; other site
335659011567	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199
335659011568	Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416
335659011569	Ribonuclease D [Translation, ribosomal structure and biogenesis]; Region: Rnd; COG0349
335659011570	DEDDy 3'-5' exonuclease domain of Ribonuclease D and similar proteins; Region: RNaseD_exo; cd06142
335659011571	catalytic site [active]
335659011572	putative active site [active]
335659011573	putative substrate binding site [chemical binding]; other site
335659011574	HRDC domain; Region: HRDC; pfam00570
335659011575	aminotransferase; Provisional; Region: PRK06105
335659011576	Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610
335659011577	inhibitor-cofactor binding pocket; inhibition site
335659011578	pyridoxal 5'-phosphate binding site [chemical binding]; other site
335659011579	catalytic residue [active]
335659011580	Isochorismatase family; Region: Isochorismatase; pfam00857
335659011581	Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cl00220
335659011582	catalytic triad [active]
335659011583	conserved cis-peptide bond; other site
335659011584	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
335659011585	Coenzyme A binding pocket [chemical binding]; other site
335659011586	Transcriptional regulator [Transcription]; Region: LysR; COG0583
335659011587	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
335659011588	LysR substrate binding domain; Region: LysR_substrate; pfam03466
335659011589	dimerization interface [polypeptide binding]; other site
335659011590	Autotransporter beta-domain; Region: Autotransporter; pfam03797
335659011591	Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea.  CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458
335659011592	DNA-binding site [nucleotide binding]; DNA binding site
335659011593	RNA-binding motif; other site
335659011594	phosphoribosylglycinamide formyltransferase; Reviewed; Region: purN; PRK05647
335659011595	Phosphoribosylglycinamide formyltransferase (GAR transformylase, GART); Region: FMT_core_GART; cd08645
335659011596	active site
335659011597	substrate binding site [chemical binding]; other site
335659011598	cosubstrate binding site; other site
335659011599	catalytic site [active]
335659011600	phosphoribosylaminoimidazole synthetase; Provisional; Region: PRK05385
335659011601	PurM (Aminoimidazole Ribonucleotide [AIR] synthetase), one of eleven enzymes required for purine biosynthesis, catalyzes the conversion of formylglycinamide ribonucleotide (FGAM) and ATP to AIR, ADP, and Pi, the fifth step in de novo purine biosynthesis; Region: PurM; cd02196
335659011602	dimerization interface [polypeptide binding]; other site
335659011603	putative ATP binding site [chemical binding]; other site
335659011604	Phosphatidylglycerophosphate synthase [Lipid metabolism]; Region: PgsA; COG0558
335659011605	ATPase involved in DNA replication initiation [DNA replication, recombination, and repair]; Region: DnaA; COG0593
335659011606	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189
335659011607	polyphosphate kinase; Provisional; Region: PRK05443
335659011608	Polyphosphate kinase N-terminal domain; Region: PP_kinase_N; pfam13089
335659011609	Polyphosphate kinase middle domain; Region: PP_kinase; pfam02503
335659011610	Catalytic C-terminal domain, first repeat, of Pseudomonas aeruginosa polyphosphate kinase 1 and similar proteins; Region: PLDc_PaPPK1_C1_like; cd09165
335659011611	putative domain interface [polypeptide binding]; other site
335659011612	putative active site [active]
335659011613	catalytic site [active]
335659011614	Catalytic C-terminal domain, second repeat, of Pseudomonas aeruginosa polyphosphate kinase 1 and similar proteins; Region: PLDc_PaPPK1_C2_like; cd09168
335659011615	putative domain interface [polypeptide binding]; other site
335659011616	putative active site [active]
335659011617	catalytic site [active]
335659011618	Exopolyphosphatase [Nucleotide transport and metabolism / Inorganic ion transport and metabolism]; Region: GppA; COG0248
335659011619	Ppx/GppA phosphatase family; Region: Ppx-GppA; pfam02541
335659011620	Uncharacterized iron-regulated membrane protein [Function unknown]; Region: PiuB; COG3182
335659011621	PepSY-associated TM helix; Region: PepSY_TM_2; pfam13703
335659011622	TonB-dependent siderophore receptor; Region: TonB-siderophor; TIGR01783
335659011623	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
335659011624	N-terminal plug; other site
335659011625	ligand-binding site [chemical binding]; other site
335659011626	integral membrane protein, YjbE family; Region: R_switched_YjbE; TIGR03717
335659011627	Nucleoside diphosphate kinase Group I (NDPk_I)-like: NDP kinase domains are present in a large family of structurally and functionally conserved proteins from bacteria to humans that generally catalyze the transfer of gamma-phosphates of a nucleoside...; Region: NDPk_I; cd04413
335659011628	active site
335659011629	multimer interface [polypeptide binding]; other site
335659011630	ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488
335659011631	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
335659011632	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
335659011633	ABC transporter; Region: ABC_tran_2; pfam12848
335659011634	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
335659011635	Tripartite tricarboxylate transporter family receptor; Region: TctC; cl17792
335659011636	Methyltransferase domain; Region: Methyltransf_23; pfam13489
335659011637	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
335659011638	S-adenosylmethionine binding site [chemical binding]; other site
335659011639	DNA polymerase III subunit chi; Validated; Region: PRK05728
335659011640	multifunctional aminopeptidase A; Provisional; Region: PRK00913
335659011641	Cytosol aminopeptidase family, N-terminal and catalytic domains.  Family M17 contains zinc- and manganese-dependent exopeptidases ( EC  3.4.11.1), including leucine aminopeptidase. They catalyze removal of amino acids from the N-terminus of a protein and...; Region: Peptidase_M17; cd00433
335659011642	interface (dimer of trimers) [polypeptide binding]; other site
335659011643	Substrate-binding/catalytic site; other site
335659011644	Zn-binding sites [ion binding]; other site
335659011645	Predicted permeases [General function prediction only]; Region: COG0795
335659011646	Predicted permease YjgP/YjgQ family; Region: YjgP_YjgQ; pfam03739
335659011647	Predicted permeases [General function prediction only]; Region: COG0795
335659011648	Predicted permease YjgP/YjgQ family; Region: YjgP_YjgQ; pfam03739
335659011649	Organic solvent tolerance protein OstA [Cell envelope biogenesis, outer membrane]; Region: Imp; COG1452
335659011650	OstA-like protein; Region: OstA; cl00844
335659011651	Organic solvent tolerance protein; Region: OstA_C; pfam04453
335659011652	Parvulin-like peptidyl-prolyl isomerase [Posttranslational modification, protein turnover, chaperones]; Region: SurA; COG0760
335659011653	SurA N-terminal domain; Region: SurA_N; pfam09312
335659011654	4-hydroxythreonine-4-phosphate dehydrogenase; Provisional; Region: pdxA; PRK05312
335659011655	4-hydroxythreonine-4-phosphate dehydrogenase; Validated; Region: pdxA; PRK03743
335659011656	16S ribosomal RNA methyltransferase KsgA/Dim1 family protein; Reviewed; Region: ksgA; PRK00274
335659011657	Dimethyladenosine transferase (rRNA methylation) [Translation, ribosomal structure and biogenesis]; Region: KsgA; COG0030
335659011658	Zn-dependent alcohol dehydrogenases [General function prediction only]; Region: AdhP; COG1064
335659011659	6-hydroxyhexanoate dehydrogenase; Region: 6_hydroxyhexanoate_dh_like; cd08240
335659011660	putative NAD(P) binding site [chemical binding]; other site
335659011661	catalytic Zn binding site [ion binding]; other site
335659011662	cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664
335659011663	Crp-like helix-turn-helix domain; Region: HTH_Crp_2; pfam13545
335659011664	Caspase domain; Region: Peptidase_C14; pfam00656
335659011665	Domain of unknown function (DUF4189); Region: DUF4189; pfam13827
335659011666	Guanylate kinase [Nucleotide transport and metabolism]; Region: Gmk; COG0194
335659011667	Guanosine monophosphate kinase (GMPK, EC 2.7.4.8), also known as guanylate kinase (GKase), catalyzes the reversible phosphoryl transfer from adenosine triphosphate (ATP) to guanosine monophosphate (GMP) to yield adenosine diphosphate (ADP) and guanosine...; Region: GMPK; cd00071
335659011668	catalytic site [active]
335659011669	G-X2-G-X-G-K; other site
335659011670	hypothetical protein; Provisional; Region: PRK11820
335659011671	YicC-like family, N-terminal region; Region: YicC_N; pfam03755
335659011672	Domain of unknown function (DUF1732); Region: DUF1732; pfam08340
335659011673	YceG-like family; Region: YceG; pfam02618
335659011674	proteins similar to Escherichia coli yceG; Region: yceG_like; cd08010
335659011675	dimerization interface [polypeptide binding]; other site
335659011676	3-oxoacyl-(acyl carrier protein) synthase II; Reviewed; Region: PRK07314
335659011677	Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834
335659011678	dimer interface [polypeptide binding]; other site
335659011679	active site
335659011680	acyl carrier protein; Provisional; Region: acpP; PRK00982
335659011681	3-ketoacyl-(acyl-carrier-protein) reductase NodG; Reviewed; Region: PRK12936
335659011682	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
335659011683	NAD(P) binding site [chemical binding]; other site
335659011684	active site
335659011685	(acyl-carrier-protein) S-malonyltransferase [Lipid metabolism]; Region: FabD; COG0331
335659011686	malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128
335659011687	This CD includes the dihydrorhizobitoxine fatty acid desaturase (RtxC) characterized in Bradyrhizobium japonicum USDA110, and other related proteins. Dihydrorhizobitoxine desaturase is reported to be involved in the final step of rhizobitoxine...; Region: Rhizobitoxine-FADS-like; cd03510
335659011688	Fatty acid desaturase; Region: FA_desaturase; pfam00487
335659011689	putative di-iron ligands [ion binding]; other site
335659011690	This CD includes the dihydrorhizobitoxine fatty acid desaturase (RtxC) characterized in Bradyrhizobium japonicum USDA110, and other related proteins. Dihydrorhizobitoxine desaturase is reported to be involved in the final step of rhizobitoxine...; Region: Rhizobitoxine-FADS-like; cd03510
335659011691	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
335659011692	30S ribosomal protein S6; Reviewed; Region: rpsF; PRK00453
335659011693	30S ribosomal protein S18; Reviewed; Region: rpsR; PRK00391
335659011694	50S ribosomal protein L9; Reviewed; Region: rplI; PRK00137
335659011695	Ribosomal protein L9, N-terminal domain; Region: Ribosomal_L9_N; pfam01281
335659011696	Ribosomal protein L9, C-terminal domain; Region: Ribosomal_L9_C; pfam03948
335659011697	PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria.  Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443
335659011698	CoenzymeA binding site [chemical binding]; other site
335659011699	subunit interaction site [polypeptide binding]; other site
335659011700	PHB binding site; other site
335659011701	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
335659011702	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
335659011703	replicative DNA helicase; Provisional; Region: PRK09165
335659011704	DnaB-like helicase N terminal domain; Region: DnaB; pfam00772
335659011705	DnaB helicase C terminal domain. The hexameric helicase DnaB unwinds the DNA duplex at the  chromosome replication fork. Although the mechanism by which DnaB both couples ATP hydrolysis to translocation along DNA and denatures the duplex is unknown, a...; Region: DnaB_C; cd00984
335659011706	Walker A motif; other site
335659011707	ATP binding site [chemical binding]; other site
335659011708	Walker B motif; other site
335659011709	DNA binding loops [nucleotide binding]
335659011710	Alanine racemase [Cell envelope biogenesis, outer membrane]; Region: Alr; COG0787
335659011711	Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Alanine Racemase; Region: PLPDE_III_AR; cd00430
335659011712	active site
335659011713	pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site
335659011714	dimer interface [polypeptide binding]; other site
335659011715	substrate binding site [chemical binding]; other site
335659011716	catalytic residues [active]
335659011717	Cysteine rich repeat; Region: Cys_rich_FGFR; pfam00839
335659011718	Escherichia coli exonuclease III (ExoIII) and Neisseria meningitides NExo-like subfamily of the ExoIII family purinic/apyrimidinic (AP) endonucleases; Region: ExoIII-like_AP-endo; cd09086
335659011719	putative catalytic site [active]
335659011720	putative phosphate binding site [ion binding]; other site
335659011721	active site
335659011722	metal binding site A [ion binding]; metal-binding site
335659011723	DNA binding site [nucleotide binding]
335659011724	putative AP binding site [nucleotide binding]; other site
335659011725	putative metal binding site B [ion binding]; other site
335659011726	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
335659011727	DNA-binding site [nucleotide binding]; DNA binding site
335659011728	Transcriptional regulators [Transcription]; Region: FadR; COG2186
335659011729	This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895
335659011730	3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084
335659011731	6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599
335659011732	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
335659011733	dimer interface [polypeptide binding]; other site
335659011734	conserved gate region; other site
335659011735	putative PBP binding loops; other site
335659011736	ABC-ATPase subunit interface; other site
335659011737	ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215
335659011738	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
335659011739	dimer interface [polypeptide binding]; other site
335659011740	conserved gate region; other site
335659011741	putative PBP binding loops; other site
335659011742	ABC-ATPase subunit interface; other site
335659011743	ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126
335659011744	ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262
335659011745	Walker A/P-loop; other site
335659011746	ATP binding site [chemical binding]; other site
335659011747	Q-loop/lid; other site
335659011748	ABC transporter signature motif; other site
335659011749	Walker B; other site
335659011750	D-loop; other site
335659011751	H-loop/switch region; other site
335659011752	Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497
335659011753	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
335659011754	substrate binding pocket [chemical binding]; other site
335659011755	membrane-bound complex binding site; other site
335659011756	hinge residues; other site
335659011757	ribose-5-phosphate isomerase B; Provisional; Region: PRK05571
335659011758	Sulfite exporter TauE/SafE; Region: TauE; pfam01925
335659011759	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054
335659011760	dimerization interface [polypeptide binding]; other site
335659011761	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
335659011762	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
335659011763	metal binding site [ion binding]; metal-binding site
335659011764	active site
335659011765	I-site; other site
335659011766	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
335659011767	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: RbsB; COG1879
335659011768	Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011
335659011769	DNA repair protein RadA; Provisional; Region: PRK11823
335659011770	Sms (bacterial radA) DNA repair protein. This protein is not related to archael radA any more than is to other RecA-like NTPases. Sms has a role in recombination and recombinational repair and is responsible for the stabilization or processing of...; Region: Sms; cd01121
335659011771	Walker A motif/ATP binding site; other site
335659011772	ATP binding site [chemical binding]; other site
335659011773	Walker B motif; other site
335659011774	Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541
335659011775	Uncharacterized membrane protein, required for colicin V production [General function prediction only]; Region: CvpA; COG1286
335659011776	Colicin V production protein; Region: Colicin_V; pfam02674
335659011777	amidophosphoribosyltransferase; Provisional; Region: PRK09123
335659011778	Glutamine amidotransferases class-II (GN-AT)_GPAT- type. This domain is found at the N-terminus of  glutamine phosphoribosylpyrophosphate (Prpp) amidotransferase (GPATase) . The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the...; Region: GPATase_N; cd00715
335659011779	active site
335659011780	tetramer interface [polypeptide binding]; other site
335659011781	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
335659011782	active site
335659011783	3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK12825
335659011784	classical (c) SDRs; Region: SDR_c; cd05233
335659011785	NAD(P) binding site [chemical binding]; other site
335659011786	active site
335659011787	NHL repeat; Region: NHL; pfam01436
335659011788	Periplasmic binding protein; Region: Peripla_BP_6; pfam13458
335659011789	Periplasmic solute-binding domain of active transport proteins that belong to the type I periplasmic binding fold protein family; Region: PBP1_SBP_like_1; cd06327
335659011790	putative ligand binding site [chemical binding]; other site
335659011791	GTP-binding protein Der; Reviewed; Region: PRK00093
335659011792	EngA1 GTPase contains the first domain of EngA; Region: EngA1; cd01894
335659011793	G1 box; other site
335659011794	GTP/Mg2+ binding site [chemical binding]; other site
335659011795	Switch I region; other site
335659011796	G2 box; other site
335659011797	Switch II region; other site
335659011798	G3 box; other site
335659011799	G4 box; other site
335659011800	G5 box; other site
335659011801	EngA2 GTPase contains the second domain of EngA; Region: EngA2; cd01895
335659011802	G1 box; other site
335659011803	GTP/Mg2+ binding site [chemical binding]; other site
335659011804	Switch I region; other site
335659011805	G2 box; other site
335659011806	G3 box; other site
335659011807	Switch II region; other site
335659011808	G4 box; other site
335659011809	G5 box; other site
335659011810	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4649
335659011811	Uncharacterized protein conserved in bacteria (DUF2133); Region: DUF2133; pfam09976
335659011812	Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318
335659011813	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
335659011814	acyl-activating enzyme (AAE) consensus motif; other site
335659011815	AMP binding site [chemical binding]; other site
335659011816	active site
335659011817	CoA binding site [chemical binding]; other site
335659011818	NnrU protein; Region: NnrU; pfam07298
335659011819	Peptide chain release factor RF-3 [Translation, ribosomal structure and biogenesis]; Region: PrfC; COG4108
335659011820	Release Factor 3 (RF3) protein involved in the terminal step of translocation in bacteria; Region: RF3; cd04169
335659011821	G1 box; other site
335659011822	putative GEF interaction site [polypeptide binding]; other site
335659011823	GTP/Mg2+ binding site [chemical binding]; other site
335659011824	Switch I region; other site
335659011825	G2 box; other site
335659011826	G3 box; other site
335659011827	Switch II region; other site
335659011828	G4 box; other site
335659011829	G5 box; other site
335659011830	RF3_II: this subfamily represents the domain II of bacterial Release Factor 3 (RF3). Termination of protein synthesis by the ribosome requires two release factor (RF) classes. The class II RF3 is a GTPase that removes class I RFs (RF1 or RF2) from the...; Region: RF3_II; cd03689
335659011831	multidrug efflux system protein; Provisional; Region: PRK11431
335659011832	Phosphate/sulphate permeases [Inorganic ion transport and metabolism]; Region: PitA; COG0306
335659011833	Phosphate transport regulator (distant homolog of PhoU) [Inorganic ion transport and metabolism]; Region: COG1392
335659011834	Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581
335659011835	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
335659011836	TM-ABC transporter signature motif; other site
335659011837	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
335659011838	Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582
335659011839	TM-ABC transporter signature motif; other site
335659011840	Periplasmic binding protein; Region: Peripla_BP_6; pfam13458
335659011841	Periplasmic solute-binding domain of active transport proteins that belong to the type I periplasmic binding fold protein family; Region: PBP1_SBP_like_1; cd06327
335659011842	putative ligand binding site [chemical binding]; other site
335659011843	ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410
335659011844	ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224
335659011845	Walker A/P-loop; other site
335659011846	ATP binding site [chemical binding]; other site
335659011847	Q-loop/lid; other site
335659011848	ABC transporter signature motif; other site
335659011849	Walker B; other site
335659011850	D-loop; other site
335659011851	H-loop/switch region; other site
335659011852	ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411
335659011853	ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219
335659011854	Walker A/P-loop; other site
335659011855	ATP binding site [chemical binding]; other site
335659011856	Q-loop/lid; other site
335659011857	ABC transporter signature motif; other site
335659011858	Walker B; other site
335659011859	D-loop; other site
335659011860	H-loop/switch region; other site
335659011861	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5388
335659011862	Arsenate Reductase (ArsC) family, Yffb subfamily; Yffb is an uncharacterized bacterial protein encoded by the yffb gene, related to the thioredoxin-fold arsenic reductases, ArsC. The structure of Yffb and the conservation of the catalytic cysteine...; Region: ArsC_Yffb; cd03035
335659011863	ArsC family; Region: ArsC; pfam03960
335659011864	putative catalytic residues [active]
335659011865	tRNA-binding-domain-containing CsaA-like proteins. CsaA is a molecular chaperone with export related activities. CsaA has a putative tRNA binding activity. The functional unit of CsaA is a homodimer and this domain acts as a dimerization domain; Region: tRNA_bind_CsaA; cd02798
335659011866	dimer interface [polypeptide binding]; other site
335659011867	putative tRNA-binding site [nucleotide binding]; other site
335659011868	Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625
335659011869	GST_N family, Ure2p-like subfamily; composed of the Saccharomyces cerevisiae Ure2p and related GSTs. Ure2p is a regulator for nitrogen catabolism in yeast. It represses the expression of several gene products involved in the use of poor nitrogen sources...; Region: GST_N_Ure2p_like; cd03048
335659011870	C-terminal domain interface [polypeptide binding]; other site
335659011871	GSH binding site (G-site) [chemical binding]; other site
335659011872	dimer interface [polypeptide binding]; other site
335659011873	C-terminal, alpha helical domain of Ure2p and related Glutathione S-transferase-like proteins; Region: GST_C_Ure2p_like; cd03178
335659011874	dimer interface [polypeptide binding]; other site
335659011875	N-terminal domain interface [polypeptide binding]; other site
335659011876	Protein of unknown function (DUF429); Region: DUF429; pfam04250
335659011877	Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680
335659011878	Beta-lactamase; Region: Beta-lactamase; pfam00144
335659011879	ribosomal-protein-alanine acetyltransferase; Region: rimI; TIGR01575
335659011880	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
335659011881	Coenzyme A binding pocket [chemical binding]; other site
335659011882	Conserved hypothetical protein (Lin0512_fam); Region: Lin0512_fam; pfam09585
335659011883	acetolactate synthase; Reviewed; Region: PRK08322
335659011884	Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035
335659011885	PYR/PP interface [polypeptide binding]; other site
335659011886	dimer interface [polypeptide binding]; other site
335659011887	TPP binding site [chemical binding]; other site
335659011888	Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205
335659011889	Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cl01629
335659011890	TPP-binding site [chemical binding]; other site
335659011891	Transcriptional regulator [Transcription]; Region: LysR; COG0583
335659011892	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
335659011893	The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_3; cd08472
335659011894	putative effector binding pocket; other site
335659011895	putative dimerization interface [polypeptide binding]; other site
335659011896	short chain dehydrogenase; Provisional; Region: PRK12937
335659011897	tetrahydroxynaphthalene/trihydroxynaphthalene reductase-like, classical (c) SDRs; Region: THN_reductase-like_SDR_c; cd05362
335659011898	NADP binding site [chemical binding]; other site
335659011899	homodimer interface [polypeptide binding]; other site
335659011900	active site
335659011901	substrate binding site [chemical binding]; other site
335659011902	Uncharacterized protein, 4-oxalocrotonate tautomerase homolog [General function prediction only]; Region: COG1942
335659011903	active site 1 [active]
335659011904	dimer interface [polypeptide binding]; other site
335659011905	hexamer interface [polypeptide binding]; other site
335659011906	active site 2 [active]
335659011907	uncharacterized peroxidase-related enzyme; Region: peroxid_rel; TIGR01926
335659011908	Carboxymuconolactone decarboxylase family; Region: CMD; pfam02627
335659011909	Protein of unknown function (DUF419); Region: DUF419; cl15265
335659011910	MarR family; Region: MarR_2; pfam12802
335659011911	Transcriptional regulators [Transcription]; Region: MarR; COG1846
335659011912	Predicted ester cyclase [General function prediction only]; Region: COG5485
335659011913	oxalate/formate antiporter family transporter; Region: 2A0111; TIGR00890
335659011914	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
335659011915	putative substrate translocation pore; other site
335659011916	RibD C-terminal domain; Region: RibD_C; cl17279
335659011917	Dihydrofolate reductase [Coenzyme metabolism]; Region: FolA; COG0262
335659011918	Short repeat of unknown function (DUF308); Region: DUF308; cl15828
335659011919	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
335659011920	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
335659011921	putative NAD(P)H quinone oxidoreductase, PIG3 family; Region: quinone_pig3; TIGR02824
335659011922	PIG3 p53-inducible quinone oxidoreductase; Region: p53_inducible_oxidoreductase; cd05276
335659011923	NAD(P) binding site [chemical binding]; other site
335659011924	Transcriptional regulator [Transcription]; Region: LysR; COG0583
335659011925	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
335659011926	The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422
335659011927	putative effector binding pocket; other site
335659011928	dimerization interface [polypeptide binding]; other site
335659011929	Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487
335659011930	active site
335659011931	catalytic residues [active]
335659011932	metal binding site [ion binding]; metal-binding site
335659011933	tetracycline repressor protein TetR; Provisional; Region: PRK13756
335659011934	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
335659011935	2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases [Coenzyme metabolism / Energy production and conversion]; Region: UbiH; COG0654
335659011936	hypothetical protein; Provisional; Region: PRK07236
335659011937	ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314
335659011938	ethanolamine utilization protein EutQ; Provisional; Region: PRK15457
335659011939	DNA-binding transcriptional regulator SoxS; Provisional; Region: PRK10219
335659011940	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
335659011941	DNA gyrase inhibitor [DNA replication, recombination, and repair]; Region: COG3449
335659011942	Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680
335659011943	Beta-lactamase; Region: Beta-lactamase; pfam00144
335659011944	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]; Region: DegQ; COG0265
335659011945	Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365
335659011946	DNA/RNA non-specific endonuclease; prokaryotic and eukaryotic double- and single-stranded DNA and RNA endonucleases also present in phosphodiesterases.  They exists as monomers and homodimers; Region: NUC; cd00091
335659011947	DNA/RNA non-specific endonuclease; Region: Endonuclease_NS; smart00892
335659011948	active site
335659011949	substrate binding site [chemical binding]; other site
335659011950	Mg2+ binding site [ion binding]; other site
335659011951	GMP synthase; Reviewed; Region: guaA; PRK00074
335659011952	Type 1 glutamine amidotransferase (GATase1) domain found in GMP synthetase; Region: GATase1_GMP_Synthase; cd01742
335659011953	AMP/PPi binding site [chemical binding]; other site
335659011954	candidate oxyanion hole; other site
335659011955	catalytic triad [active]
335659011956	potential glutamine specificity residues [chemical binding]; other site
335659011957	The C-terminal domain of GMP synthetase. It contains two subdomains; the ATP pyrophosphatase domain which closes to the N-termial and the dimerization domain at C-terminal end. The ATP-PPase is a twisted, five-stranded parallel beta-sheet sandwiched...; Region: GMP_synthase_C; cd01997
335659011958	ATP Binding subdomain [chemical binding]; other site
335659011959	Ligand Binding sites [chemical binding]; other site
335659011960	Dimerization subdomain; other site
335659011961	SnoaL-like domain; Region: SnoaL_2; pfam12680
335659011962	Predicted transcriptional regulators [Transcription]; Region: COG1733
335659011963	HxlR-like helix-turn-helix; Region: HxlR; pfam01638
335659011964	Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814
335659011965	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
335659011966	putative substrate translocation pore; other site
335659011967	Cupin domain; Region: Cupin_2; cl17218
335659011968	Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea.  CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458
335659011969	DNA-binding site [nucleotide binding]; DNA binding site
335659011970	RNA-binding motif; other site
335659011971	tRNA and rRNA cytosine-C5-methylases [Translation, ribosomal structure and biogenesis]; Region: Sun; COG0144
335659011972	NOL1/NOP2/sun family putative RNA methylase; Region: nop2p; TIGR00446
335659011973	MAPEG family; Region: MAPEG; cl09190
335659011974	metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995
335659011975	Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149
335659011976	active site
335659011977	metal binding site [ion binding]; metal-binding site
335659011978	Putative NADP-dependent oxidoreductases [General function prediction only]; Region: COG2130
335659011979	Prostaglandin dehydrogenases; Region: PGDH; cd05288
335659011980	NAD(P) binding site [chemical binding]; other site
335659011981	substrate binding site [chemical binding]; other site
335659011982	dimer interface [polypeptide binding]; other site
335659011983	inosine 5'-monophosphate dehydrogenase; Reviewed; Region: PRK05567
335659011984	TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186
335659011985	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in the inosine 5' monophosphate dehydrogenase (IMPDH) protein.  IMPDH is an essential enzyme that catalyzes the first step unique to GTP synthesis, playing a...; Region: CBS_pair_IMPDH; cd04601
335659011986	IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381
335659011987	active site
335659011988	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
335659011989	Major Facilitator Superfamily; Region: MFS_1; pfam07690
335659011990	putative substrate translocation pore; other site
335659011991	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
335659011992	23S rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: FtsJ; COG0293
335659011993	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
335659011994	S-adenosylmethionine binding site [chemical binding]; other site
335659011995	exopolyphosphatase; Region: exo_poly_only; TIGR03706
335659011996	Ppx/GppA phosphatase family; Region: Ppx-GppA; pfam02541
335659011997	Aerobic-type carbon monoxide dehydrogenase, large subunit CoxL/CutL homologs [Energy production and conversion]; Region: CoxL; COG1529
335659011998	Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; smart01008
335659011999	Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738
335659012000	The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509
335659012001	active site 1 [active]
335659012002	active site 2 [active]
335659012003	hypothetical protein; Validated; Region: PRK00124
335659012004	ABC transporter ATPase component; Reviewed; Region: PRK11147
335659012005	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
335659012006	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
335659012007	Predicted amino acid aldolase or racemase [Amino acid transport and metabolism]; Region: COG3616
335659012008	Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes; Region: PLPDE_III; cl00261
335659012009	pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site
335659012010	catalytic residue [active]
335659012011	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
335659012012	uncharacterized flavoprotein, PP_4765 family; Region: flavo_PP4765; TIGR03862
335659012013	3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557
335659012014	(3R)-hydroxyacyl-CoA dehydrogenase-like, classical(c)-like SDRs; Region: hydroxyacyl-CoA-like_DH_SDR_c-like; cd05353
335659012015	NAD binding site [chemical binding]; other site
335659012016	homodimer interface [polypeptide binding]; other site
335659012017	active site
335659012018	NodN (nodulation factor N) contains a single hot dog fold similar to those of the peroxisomal Hydratase-Dehydrogenase-Epimerase (HDE) protein, and the fatty acid synthase beta subunit.  Rhizobium and related species form nodules on the roots of their...; Region: NodN; cd03450
335659012019	putative active site [active]
335659012020	putative catalytic site [active]
335659012021	Acyl-coenzyme A synthetases/AMP-(fatty) acid ligases [Lipid metabolism]; Region: Acs; COG0365
335659012022	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
335659012023	acyl-activating enzyme (AAE) consensus motif; other site
335659012024	AMP binding site [chemical binding]; other site
335659012025	active site
335659012026	CoA binding site [chemical binding]; other site
335659012027	6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599
335659012028	3-hydroxyisobutyrate dehydrogenase; Region: HIBADH; TIGR01692
335659012029	3-hydroxyisobutyryl-CoA hydrolase; Provisional; Region: PRK05617
335659012030	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
335659012031	substrate binding site [chemical binding]; other site
335659012032	oxyanion hole (OAH) forming residues; other site
335659012033	trimer interface [polypeptide binding]; other site
335659012034	2-enoyl-CoA Hydratase C-terminal region; Region: ECH_C; pfam13766
335659012035	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
335659012036	Isobutyryl-CoA dehydrogenase; Region: IBD; cd01162
335659012037	substrate binding pocket [chemical binding]; other site
335659012038	FAD binding site [chemical binding]; other site
335659012039	catalytic base [active]
335659012040	Methylmalonate semialdehyde dehydrogenase and ALDH family members 6A1 and 6B2; Region: ALDH_F6_MMSDH; cd07085
335659012041	methylmalonic acid semialdehyde dehydrogenase; Region: MMSDH; TIGR01722
335659012042	tetrameric interface [polypeptide binding]; other site
335659012043	NAD binding site [chemical binding]; other site
335659012044	catalytic residues [active]
335659012045	Transcriptional regulator [Transcription]; Region: LysR; COG0583
335659012046	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
335659012047	The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422
335659012048	putative effector binding pocket; other site
335659012049	dimerization interface [polypeptide binding]; other site
335659012050	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
335659012051	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
335659012052	PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria.  Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443
335659012053	CoenzymeA binding site [chemical binding]; other site
335659012054	subunit interaction site [polypeptide binding]; other site
335659012055	PHB binding site; other site
335659012056	Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024
335659012057	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
335659012058	substrate binding site [chemical binding]; other site
335659012059	oxyanion hole (OAH) forming residues; other site
335659012060	trimer interface [polypeptide binding]; other site
335659012061	acetyl-CoA acetyltransferase; Provisional; Region: PRK06954
335659012062	Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751
335659012063	dimer interface [polypeptide binding]; other site
335659012064	active site
335659012065	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
335659012066	Major Facilitator Superfamily; Region: MFS_1; pfam07690
335659012067	putative substrate translocation pore; other site
335659012068	flagellar hook-associated protein FlgK; Provisional; Region: flgK; PRK12715
335659012069	Pilus formation protein N terminal region; Region: T2SS-T3SS_pil_N; pfam13629
335659012070	Flp pilus assembly protein, secretin CpaC [Intracellular trafficking and secretion]; Region: CpaC; COG4964
335659012071	BON domain; Region: BON; pfam04972
335659012072	Bacterial type II and III secretion system protein; Region: Secretin; pfam00263
335659012073	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
335659012074	DNA binding site [nucleotide binding]
335659012075	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189
335659012076	Predicted ATPase [General function prediction only]; Region: COG3903
335659012077	Walker A motif; other site
335659012078	ATP binding site [chemical binding]; other site
335659012079	Aerobic-type carbon monoxide dehydrogenase, small subunit CoxS/CutS homologs [Energy production and conversion]; Region: CoxS; COG2080
335659012080	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
335659012081	catalytic loop [active]
335659012082	iron binding site [ion binding]; other site
335659012083	[2Fe-2S] binding domain; Region: Fer2_2; pfam01799
335659012084	Aerobic-type carbon monoxide dehydrogenase, large subunit CoxL/CutL homologs [Energy production and conversion]; Region: CoxL; COG1529
335659012085	Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; smart01008
335659012086	Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738
335659012087	Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738
335659012088	Acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta) [Lipid metabolism]; Region: COG4799
335659012089	Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; cl17345
335659012090	Transcriptional regulator [Transcription]; Region: IclR; COG1414
335659012091	The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850
335659012092	carboxyltransferase (CT) interaction site; other site
335659012093	biotinylation site [posttranslational modification]; other site
335659012094	TRAP transporter solute receptor, TAXI family; Region: TRAP_TAXI; TIGR02122
335659012095	TRAP transporter, 4TM/12TM fusion protein; Region: TRAP_fused; TIGR02123
335659012096	DctM-like transporters; Region: DctM; pfam06808
335659012097	glutaminase A; Region: Gln_ase; TIGR03814
335659012098	Glutaminase [Amino acid transport and metabolism]; Region: GlsA; COG2066
335659012099	Sulphate Transporter and Anti-Sigma factor antagonist domain found in the C-terminal region of sulphate transporters as well as in bacterial and archaeal proteins involved in the regulation of sigma factors; Region: STAS; cl00604
335659012100	cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664
335659012101	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
335659012102	ligand binding site [chemical binding]; other site
335659012103	flexible hinge region; other site
335659012104	Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in a group of uncharacterized proteins from bacteria and archaea; Region: NTP-PPase_u4; cd11541
335659012105	putative metal binding site [ion binding]; other site
335659012106	Carboxymuconolactone decarboxylase family; Region: CMD; pfam02627
335659012107	Uncharacterized conserved protein [Function unknown]; Region: COG2128
335659012108	Rubredoxin-like zinc ribbon domain (DUF35_N); Region: DUF35_N; pfam12172
335659012109	DUF35 OB-fold domain; Region: DUF35; pfam01796
335659012110	thiolase; Provisional; Region: PRK06158
335659012111	Thiolase domain associated with sterol carrier protein (SCP)-x isoform and related proteins; SCP-2  has multiple roles in intracellular lipid circulation and metabolism. The N-terminal presequence in the SCP-x isoform represents a peroxisomal...; Region: SCP-x_thiolase; cd00829
335659012112	active site
335659012113	Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804
335659012114	CoA-transferase family III; Region: CoA_transf_3; pfam02515
335659012115	acetyl-CoA acetyltransferase; Provisional; Region: PRK07516
335659012116	Thiolase domain associated with sterol carrier protein (SCP)-x isoform and related proteins; SCP-2  has multiple roles in intracellular lipid circulation and metabolism. The N-terminal presequence in the SCP-x isoform represents a peroxisomal...; Region: SCP-x_thiolase; cd00829
335659012117	active site
335659012118	keto-hydroxyglutarate-aldolase/keto-deoxy- phosphogluconate aldolase; Provisional; Region: PRK05718
335659012119	KDPG and KHG aldolase; Region: KDPG_aldolase; cd00452
335659012120	active site
335659012121	intersubunit interface [polypeptide binding]; other site
335659012122	catalytic residue [active]
335659012123	Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524
335659012124	2-keto-3-deoxygluconate kinase (KdgK) phosphorylates 2-keto-3-deoxygluconate (KDG) to form 2-keto-3-deoxy-6-phosphogluconate (KDGP). KDG is the common intermediate product, that allows organisms to channel D-glucuronate and/or D-galacturinate into the...; Region: KdgK; cd01166
335659012125	substrate binding site [chemical binding]; other site
335659012126	ATP binding site [chemical binding]; other site
335659012127	Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451
335659012128	Escherichia coli Gne (a nucleoside-diphosphate-sugar 4-epimerase)-like, extended (e) SDRs; Region: Gne_like_SDR_e; cd05238
335659012129	putative NAD(P) binding site [chemical binding]; other site
335659012130	active site
335659012131	putative substrate binding site [chemical binding]; other site
335659012132	ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395
335659012133	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
335659012134	dimer interface [polypeptide binding]; other site
335659012135	conserved gate region; other site
335659012136	putative PBP binding loops; other site
335659012137	ABC-ATPase subunit interface; other site
335659012138	ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177
335659012139	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
335659012140	dimer interface [polypeptide binding]; other site
335659012141	conserved gate region; other site
335659012142	putative PBP binding loops; other site
335659012143	ABC-ATPase subunit interface; other site
335659012144	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547
335659012145	Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416
335659012146	glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650
335659012147	The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301
335659012148	Walker A/P-loop; other site
335659012149	ATP binding site [chemical binding]; other site
335659012150	Q-loop/lid; other site
335659012151	ABC transporter signature motif; other site
335659012152	Walker B; other site
335659012153	D-loop; other site
335659012154	H-loop/switch region; other site
335659012155	TOBE domain; Region: TOBE_2; pfam08402
335659012156	Transcriptional regulators [Transcription]; Region: PurR; COG1609
335659012157	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
335659012158	DNA binding site [nucleotide binding]
335659012159	domain linker motif; other site
335659012160	Ligand-binding domain of DNA transcription repressor GntR specific for gluconate, a member of the LacI-GalR family of bacterial transcription regulators; Region: PBP1_GntR; cd01575
335659012161	putative dimerization interface [polypeptide binding]; other site
335659012162	putative ligand binding site [chemical binding]; other site
335659012163	dihydroxy-acid dehydratase; Provisional; Region: PRK13017
335659012164	3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK07231
335659012165	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
335659012166	NAD(P) binding site [chemical binding]; other site
335659012167	active site
335659012168	3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653
335659012169	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
335659012170	NAD(P) binding site [chemical binding]; other site
335659012171	active site
335659012172	EamA-like transporter family; Region: EamA; pfam00892
335659012173	Transcriptional regulator [Transcription]; Region: LysR; COG0583
335659012174	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
335659012175	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
335659012176	dimerization interface [polypeptide binding]; other site
335659012177	Uncharacterized homologs of Site-2 protease (S2P), zinc metalloproteases (MEROPS family M50) which cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of the...; Region: S2P-M50_like_1; cd06158
335659012178	Peptidase family M50; Region: Peptidase_M50; pfam02163
335659012179	active site
335659012180	putative substrate binding region [chemical binding]; other site
335659012181	protein-export membrane protein SecF; Region: 3a0501s07; TIGR00966
335659012182	TonB C terminal; Region: TonB_2; pfam13103
335659012183	Biopolymer transport protein ExbD/TolR; Region: ExbD; cl00537
335659012184	Biopolymer transport protein [Intracellular trafficking and secretion]; Region: ExbD; COG0848
335659012185	MotA/TolQ/ExbB proton channel family; Region: MotA_ExbB; cl00568
335659012186	Fe(II)-dependent oxygenase superfamily protein; Provisional; Region: PRK05467
335659012187	Outer membrane receptor for monomeric catechols [Inorganic ion transport and metabolism]; Region: Fiu; COG4774
335659012188	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
335659012189	N-terminal plug; other site
335659012190	ligand-binding site [chemical binding]; other site
335659012191	multidrug efflux system subunit MdtA; Provisional; Region: PRK11556
335659012192	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
335659012193	HlyD family secretion protein; Region: HlyD_3; pfam13437
335659012194	multidrug efflux system subunit MdtB; Provisional; Region: PRK10503
335659012195	Protein export membrane protein; Region: SecD_SecF; cl14618
335659012196	Invasion associated locus B (IalB) protein; Region: IalB; pfam06776
335659012197	Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119
335659012198	Sulfatase; Region: Sulfatase; pfam00884
335659012199	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
335659012200	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
335659012201	Sel1 repeat; Region: Sel1; cl02723
335659012202	ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410
335659012203	ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224
335659012204	Walker A/P-loop; other site
335659012205	ATP binding site [chemical binding]; other site
335659012206	Q-loop/lid; other site
335659012207	ABC transporter signature motif; other site
335659012208	Walker B; other site
335659012209	D-loop; other site
335659012210	H-loop/switch region; other site
335659012211	ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411
335659012212	ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219
335659012213	Walker A/P-loop; other site
335659012214	ATP binding site [chemical binding]; other site
335659012215	Q-loop/lid; other site
335659012216	ABC transporter signature motif; other site
335659012217	Walker B; other site
335659012218	D-loop; other site
335659012219	H-loop/switch region; other site
335659012220	ABC-type branched-chain amino acid transport system, permease component [Amino acid transport and metabolism]; Region: LivM; COG4177
335659012221	Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581
335659012222	TM-ABC transporter signature motif; other site
335659012223	Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582
335659012224	TM-ABC transporter signature motif; other site
335659012225	ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683
335659012226	Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011
335659012227	Protein of unknown function (DUF1428); Region: DUF1428; pfam07237
335659012228	Caspase domain; Region: Peptidase_C14; pfam00656
335659012229	Caspase domain; Region: Peptidase_C14; pfam00656
335659012230	Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446
335659012231	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3224
335659012232	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3224
335659012233	guanine deaminase; Provisional; Region: PRK09228
335659012234	Guanine deaminase (GDEase). Guanine deaminase is an aminohydrolase responsible for the conversion of guanine to xanthine and ammonia, the first step to utilize guanine as a nitrogen source. This reaction also removes the guanine base from the pool and...; Region: GDEase; cd01303
335659012235	active site
335659012236	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
335659012237	3-oxoadipate enol-lactonase; Region: protocat_pcaD; TIGR02427
335659012238	Transcriptional regulators [Transcription]; Region: GntR; COG1802
335659012239	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
335659012240	DNA-binding site [nucleotide binding]; DNA binding site
335659012241	FCD domain; Region: FCD; pfam07729
335659012242	Aldehyde dehydrogenase family; Region: Aldedh; pfam00171
335659012243	Uncharacterized Candidatus pelagibacter aldehyde dehydrogenase, DhaS-like; Region: ALDH_DhaS; cd07114
335659012244	NAD(P) binding site [chemical binding]; other site
335659012245	catalytic residues [active]
335659012246	benzoate transport; Region: 2A0115; TIGR00895
335659012247	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
335659012248	putative substrate translocation pore; other site
335659012249	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
335659012250	Protein of unknown function (DUF1349); Region: DUF1349; pfam07081
335659012251	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
335659012252	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
335659012253	RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730
335659012254	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
335659012255	HlyD family secretion protein; Region: HlyD_3; pfam13437
335659012256	AcrB/AcrD/AcrF family; Region: ACR_tran; pfam00873
335659012257	Sulfite exporter TauE/SafE; Region: TauE; pfam01925
335659012258	Ammonium Transporter Family; Region: Ammonium_transp; cl03012
335659012259	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
335659012260	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
335659012261	DNA binding residues [nucleotide binding]
335659012262	dimerization interface [polypeptide binding]; other site
335659012263	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
335659012264	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
335659012265	DNA binding residues [nucleotide binding]
335659012266	dimerization interface [polypeptide binding]; other site
335659012267	Autotransporter beta-domain; Region: Autotransporter; pfam03797
335659012268	Protein of unknown function (DUF3455); Region: DUF3455; pfam11937
335659012269	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
335659012270	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
335659012271	PAS domain; Region: PAS; smart00091
335659012272	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
335659012273	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
335659012274	DNA binding residues [nucleotide binding]
335659012275	dimerization interface [polypeptide binding]; other site
335659012276	YdeM is a Bacillus subtilis protein that belongs to a family of prokaryotic proteins of unkown function.  YdeM has sequence similarity to the hot-dog fold of (R)-specific enoyl-CoA hydratase.   Other enzymes with this fold include the peroxisomal...; Region: YdeM; cd03454
335659012277	putative active site [active]
335659012278	putative catalytic site [active]
335659012279	Transglycosylase SLT domain; Region: SLT_2; pfam13406
335659012280	murein hydrolase B; Provisional; Region: PRK10760; cl17906
335659012281	Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072
335659012282	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738
335659012283	long-chain-fatty-acid--CoA ligase; Validated; Region: PRK07008
335659012284	Fatty acyl-CoA synthetases similar to LC-FACS from Thermus thermophiles; Region: ttLC_FACS_AlkK_like; cd12119
335659012285	dimer interface [polypeptide binding]; other site
335659012286	acyl-activating enzyme (AAE) consensus motif; other site
335659012287	putative active site [active]
335659012288	AMP binding site [chemical binding]; other site
335659012289	putative CoA binding site [chemical binding]; other site
335659012290	Protein of unknown function (DUF2961); Region: DUF2961; pfam11175
335659012291	Porin subfamily; Region: Porin_2; pfam02530
335659012292	Opacity protein and related surface antigens [Cell envelope biogenesis, outer membrane]; Region: COG3637
335659012293	Porin subfamily; Region: Porin_2; pfam02530
335659012294	Opacity protein and related surface antigens [Cell envelope biogenesis, outer membrane]; Region: COG3637
335659012295	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
335659012296	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
335659012297	active site
335659012298	efflux pump membrane protein (multidrug resistance protein A); Region: 8a0101; TIGR00998
335659012299	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
335659012300	HlyD family secretion protein; Region: HlyD_3; pfam13437
335659012301	Protein of unknown function (DUF1656); Region: DUF1656; pfam07869
335659012302	Fusaric acid resistance protein family; Region: FUSC; pfam04632
335659012303	Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515
335659012304	helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347
335659012305	MarR family; Region: MarR_2; pfam12802
335659012306	glutamate and aspartate transporter subunit; Provisional; Region: PRK10797
335659012307	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
335659012308	substrate binding pocket [chemical binding]; other site
335659012309	membrane-bound complex binding site; other site
335659012310	hinge residues; other site
335659012311	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
335659012312	Cytosine deaminase and related metal-dependent hydrolases [Nucleotide transport and metabolism / General function prediction only]; Region: SsnA; COG0402
335659012313	active site
335659012314	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
335659012315	substrate binding pocket [chemical binding]; other site
335659012316	NMT1/THI5 like; Region: NMT1; pfam09084
335659012317	membrane-bound complex binding site; other site
335659012318	hinge residues; other site
335659012319	ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600
335659012320	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
335659012321	dimer interface [polypeptide binding]; other site
335659012322	conserved gate region; other site
335659012323	putative PBP binding loops; other site
335659012324	ABC-ATPase subunit interface; other site
335659012325	ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116
335659012326	ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293
335659012327	Walker A/P-loop; other site
335659012328	ATP binding site [chemical binding]; other site
335659012329	Q-loop/lid; other site
335659012330	ABC transporter signature motif; other site
335659012331	Walker B; other site
335659012332	D-loop; other site
335659012333	H-loop/switch region; other site
335659012334	Transcriptional regulators [Transcription]; Region: GntR; COG1802
335659012335	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
335659012336	DNA-binding site [nucleotide binding]; DNA binding site
335659012337	FCD domain; Region: FCD; pfam07729
335659012338	cytosine deaminase; Provisional; Region: PRK05985
335659012339	Bacterial cytosine deaminase and related metal-dependent hydrolases. Cytosine deaminases (CDs) catalyze the deamination of cytosine, producing uracil and ammonia. They play an important role in pyrimidine salvage. CDs are present in prokaryotes and fungi; Region: Bact_CD; cd01293
335659012340	active site
335659012341	cytosine deaminase; Provisional; Region: PRK05985
335659012342	Bacterial cytosine deaminase and related metal-dependent hydrolases. Cytosine deaminases (CDs) catalyze the deamination of cytosine, producing uracil and ammonia. They play an important role in pyrimidine salvage. CDs are present in prokaryotes and fungi; Region: Bact_CD; cd01293
335659012343	active site
335659012344	3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084
335659012345	Domain of unknown function (DUF1932); Region: DUF1932; pfam09130
335659012346	NMT1/THI5 like; Region: NMT1; pfam09084
335659012347	hypothetical protein; Provisional; Region: PRK09262
335659012348	Uncharacterized proteins, LmbE homologs [Function unknown]; Region: COG2120
335659012349	Predicted metal-dependent hydrolase of the TIM-barrel fold [General function prediction only]; Region: COG3618
335659012350	2-pyrone-4,6-dicarboxylic acid (PDC) hydrolase hydrolyzes PDC to yield 4-oxalomesaconic acid (OMA) or its tautomer, 4-carboxy-2-hydroxymuconic acid (CHM). This reaction is part of the protocatechuate (PCA) 4,5-cleavage pathway. PCA is one of the most...; Region: PDC_hydrolase; cd01311
335659012351	active site
335659012352	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
335659012353	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
335659012354	Tripartite tricarboxylate transporter family receptor; Region: TctC; cl17792
335659012355	PepSY-associated TM helix; Region: PepSY_TM_3; pfam13706
335659012356	Protein of unknown function (DUF763); Region: DUF763; pfam05559
335659012357	Flavodoxin reductases (ferredoxin-NADPH reductases) family 1 [Energy production and conversion]; Region: Hmp; COG1018
335659012358	Ferredoxin-NADP+ (oxido)reductase is an FAD-containing enzyme that catalyzes the reversible electron transfer between NADP(H) and electron carrier proteins such as ferredoxin and flavodoxin. Isoforms of these flavoproteins (i.e. having a non-covalently...; Region: FNR1; cd06195
335659012359	FAD binding pocket [chemical binding]; other site
335659012360	FAD binding motif [chemical binding]; other site
335659012361	phosphate binding motif [ion binding]; other site
335659012362	beta-alpha-beta structure motif; other site
335659012363	NAD binding pocket [chemical binding]; other site
335659012364	Amidohydrolase; Region: Amidohydro_5; pfam13594
335659012365	Amidohydrolase; Region: Amidohydro_4; pfam13147
335659012366	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cd01292
335659012367	active site
335659012368	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
335659012369	Transcriptional regulators [Transcription]; Region: MarR; COG1846
335659012370	MarR family; Region: MarR_2; cl17246
335659012371	ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410
335659012372	ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224
335659012373	Walker A/P-loop; other site
335659012374	ATP binding site [chemical binding]; other site
335659012375	Q-loop/lid; other site
335659012376	ABC transporter signature motif; other site
335659012377	Walker B; other site
335659012378	D-loop; other site
335659012379	H-loop/switch region; other site
335659012380	ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411
335659012381	ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219
335659012382	Walker A/P-loop; other site
335659012383	ATP binding site [chemical binding]; other site
335659012384	Q-loop/lid; other site
335659012385	ABC transporter signature motif; other site
335659012386	Walker B; other site
335659012387	D-loop; other site
335659012388	H-loop/switch region; other site
335659012389	Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582
335659012390	TM-ABC transporter signature motif; other site
335659012391	ABC-type branched-chain amino acid transport system, permease component [Amino acid transport and metabolism]; Region: LivM; COG4177
335659012392	Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581
335659012393	TM-ABC transporter signature motif; other site
335659012394	Periplasmic binding protein; Region: Peripla_BP_6; pfam13458
335659012395	Periplasmic solute-binding domain of active transport proteins; Region: PBP1_Arsenic_SBP_like; cd06330
335659012396	putative ligand binding site [chemical binding]; other site
335659012397	Amino acid synthesis; Region: AA_synth; pfam06684
335659012398	hypothetical protein; Provisional; Region: PRK04334
335659012399	Aerobic-type carbon monoxide dehydrogenase, small subunit CoxS/CutS homologs [Energy production and conversion]; Region: CoxS; COG2080
335659012400	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
335659012401	catalytic loop [active]
335659012402	iron binding site [ion binding]; other site
335659012403	[2Fe-2S] binding domain; Region: Fer2_2; pfam01799
335659012404	Aerobic-type carbon monoxide dehydrogenase, large subunit CoxL/CutL homologs [Energy production and conversion]; Region: CoxL; COG1529
335659012405	Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738
335659012406	Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; smart01008
335659012407	Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738
335659012408	Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738
335659012409	Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010
335659012410	Cytochrome C oxidase, cbb3-type, subunit III; Region: Cytochrome_CBB3; pfam13442
335659012411	N-terminal, non-catalytic, domain of BphC_JF8, (2,3-dihydroxybiphenyl 1,2-dioxygenase) from Bacillus sp. JF8 and similar proteins; Region: BphC-JF8_N_like; cd09013
335659012412	tetramer interface [polypeptide binding]; other site
335659012413	catechol 2,3 dioxygenase; Region: catechol_2_3; TIGR03211
335659012414	C-terminal, catalytic, domain of BphC_JF8, (2,3-dihydroxybiphenyl 1,2-dioxygenase) from Bacillus sp. JF8 and similar proteins; Region: BphC-JF8_C_like; cd09014
335659012415	tetramer interface [polypeptide binding]; other site
335659012416	active site
335659012417	metal binding site [ion binding]; metal-binding site
335659012418	HerA helicase [Replication, recombination, and repair]; Region: COG0433
335659012419	Domain of unknown function DUF87; Region: DUF87; pfam01935
335659012420	uncharacterized peroxidase-related enzyme; Region: peroxid_rel; TIGR01926
335659012421	PA26 p53-induced protein (sestrin); Region: PA26; pfam04636
335659012422	alkylhydroperoxidase AhpD family core domain; Region: ahpD_dom; TIGR00778
335659012423	Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; smart00831
335659012424	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
335659012425	ATPase, P-type (transporting), HAD superfamily, subfamily IC; Region: ATPase_P-type; TIGR01494
335659012426	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
335659012427	motif II; other site
335659012428	Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689
335659012429	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
335659012430	cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664
335659012431	ligand binding site [chemical binding]; other site
335659012432	flexible hinge region; other site
335659012433	helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092
335659012434	non-specific DNA interactions [nucleotide binding]; other site
335659012435	DNA binding site [nucleotide binding]
335659012436	sequence specific DNA binding site [nucleotide binding]; other site
335659012437	putative cAMP binding site [chemical binding]; other site
335659012438	Putative ParB-like nuclease; Region: ParBc_2; pfam08857
335659012439	acyl carrier protein; Provisional; Region: PRK06508
335659012440	3-hydroxymyristoyl/3-hydroxydecanoyl-(acyl carrier protein) dehydratases [Lipid metabolism]; Region: FabA; COG0764
335659012441	active site 2 [active]
335659012442	active site 1 [active]
335659012443	3-oxoacyl-(acyl carrier protein) synthase II; Reviewed; Region: PRK06519
335659012444	Condensing enzymes; Family of enzymes that catalyze a (decarboxylating or non-decarboxylating) Claisen-like condensation reaction. Members are share strong structural similarity, and are involved in the synthesis and degradation of fatty acids, and the...; Region: cond_enzymes; cl09938
335659012445	active site
335659012446	3-oxoacyl-(acyl carrier protein) synthase II; Reviewed; Region: PRK06501
335659012447	Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834
335659012448	dimer interface [polypeptide binding]; other site
335659012449	active site
335659012450	Bacterial lipid A biosynthesis acyltransferase; Region: Lip_A_acyltrans; pfam03279
335659012451	Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LABLAT-like; Region: LPLAT_LABLAT-like; cd07984
335659012452	putative acyl-acceptor binding pocket; other site
335659012453	putrescine transporter subunit: periplasmic-binding component of ABC superfamily; Provisional; Region: PRK10682
335659012454	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199
335659012455	hypothetical protein; Provisional; Region: PRK08912
335659012456	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
335659012457	pyridoxal 5'-phosphate binding site [chemical binding]; other site
335659012458	homodimer interface [polypeptide binding]; other site
335659012459	catalytic residue [active]
335659012460	Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158
335659012461	active site residue [active]
335659012462	K+ transporter [Inorganic ion transport and metabolism]; Region: Kup; COG3158
335659012463	potassium uptake protein; Region: kup; TIGR00794
335659012464	K+ transporter [Inorganic ion transport and metabolism]; Region: Kup; COG3158
335659012465	potassium uptake protein; Region: kup; TIGR00794
335659012466	Flagellar motor protein [Cell motility and secretion]; Region: MotB; COG1360
335659012467	Membrane MotB of proton-channel complex MotA/MotB; Region: MotB_plug; pfam13677
335659012468	Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185
335659012469	ligand binding site [chemical binding]; other site
335659012470	MotA/TolQ/ExbB proton channel family; Region: MotA_ExbB; cl00568
335659012471	Demethylmenaquinone methyltransferase; Region: Methyltransf_6; cl00480
335659012472	Phosphatidylserine synthase [Lipid metabolism]; Region: PssA; COG1183
335659012473	CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; pfam01066
335659012474	CDP-alcohol phosphatidyltransferase 2; Region: CDP-OH_P_tran_2; pfam08009
335659012475	phosphatidylserine decarboxylase; Provisional; Region: PRK05305
335659012476	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
335659012477	ABC-type transport system involved in Fe-S cluster assembly, permease and ATPase components [Posttranslational modification, protein turnover, chaperones]; Region: ATM1; COG5265
335659012478	ATP-binding cassette domain of iron-sulfur clusters transporter, subfamily C; Region: ABCC_ATM1_transporter; cd03253
335659012479	Walker A/P-loop; other site
335659012480	ATP binding site [chemical binding]; other site
335659012481	Q-loop/lid; other site
335659012482	ABC transporter signature motif; other site
335659012483	Walker B; other site
335659012484	D-loop; other site
335659012485	H-loop/switch region; other site
335659012486	Predicted Rossmann fold nucleotide-binding protein [General function prediction only]; Region: COG1611
335659012487	This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_19; cd07262
335659012488	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
335659012489	putative alpha-isopropylmalate/homocitrate synthase family transferase; Provisional; Region: PRK12344
335659012490	Desulfobacterium autotrophicum LeuA3 and related proteins, N-terminal catalytic TIM barrel domain; Region: DRE_TIM_LeuA3; cd07941
335659012491	active site
335659012492	catalytic residues [active]
335659012493	metal binding site [ion binding]; metal-binding site
335659012494	LeuA allosteric (dimerisation) domain; Region: LeuA_dimer; smart00917
335659012495	Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673
335659012496	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
335659012497	Coenzyme A binding pocket [chemical binding]; other site
335659012498	cysteinyl-tRNA synthetase; Validated; Region: cysS; PRK00260
335659012499	catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672
335659012500	active site
335659012501	HIGH motif; other site
335659012502	catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672
335659012503	KMSKS motif; other site
335659012504	Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020
335659012505	Protein of unknown function (DUF2865); Region: DUF2865; pfam11064
335659012506	NAD synthetase; Provisional; Region: PRK13981
335659012507	Glutamine aminotransferase (GAT, glutaminase) domain of glutamine-dependent NAD synthetases (class 7 and 8 nitrilases); Region: GAT_Gln-NAD-synth; cd07570
335659012508	multimer interface [polypeptide binding]; other site
335659012509	active site
335659012510	catalytic triad [active]
335659012511	protein interface 1 [polypeptide binding]; other site
335659012512	NAD+ synthase is a homodimer, which catalyzes the final step in de novo nicotinamide adenine dinucleotide (NAD+) biosynthesis, an amide transfer from either ammonia or glutamine to nicotinic acid adenine dinucleotide (NaAD). The conversion of NaAD to NAD...; Region: NAD_synthase; cd00553
335659012513	homodimer interface [polypeptide binding]; other site
335659012514	NAD binding pocket [chemical binding]; other site
335659012515	ATP binding pocket [chemical binding]; other site
335659012516	Mg binding site [ion binding]; other site
335659012517	active-site loop [active]
335659012518	Diacylglycerol kinase [Cell envelope biogenesis, outer membrane]; Region: DgkA; COG0818
335659012519	Class-II DAHP synthetase family; Region: DAHP_synth_2; pfam01474
335659012520	Predicted alpha/beta hydrolase [General function prediction only]; Region: COG4757
335659012521	Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326
335659012522	N-terminal domain of molybdenum-binding protein [General function prediction only]; Region: ModE; COG2005
335659012523	Transcriptional regulator [Transcription]; Region: LysR; COG0583
335659012524	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
335659012525	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
335659012526	dimerization interface [polypeptide binding]; other site
335659012527	Helix-turn-helix domain; Region: HTH_18; pfam12833
335659012528	hypothetical protein; Provisional; Region: PRK05208
335659012529	integral membrane protein, YjbE family; Region: R_switched_YjbE; TIGR03717
335659012530	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
335659012531	COPI associated protein; Region: COPI_assoc; pfam08507
335659012532	tellurium resistance terB-like protein; Region: terB_like; cd07177
335659012533	metal binding site [ion binding]; metal-binding site
335659012534	MOSC domain; Region: MOSC; pfam03473
335659012535	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2258
335659012536	3-alpha domain; Region: 3-alpha; pfam03475
335659012537	FAD_NAD(P)H binding domain of flavohemoglobin. Flavohemoglobins have a globin domain containing a B-type heme fused with a ferredoxin reductase-like FAD/NAD-binding domain. Flavohemoglobins detoxify nitric oxide (NO) via an NO dioxygenase reaction. The...; Region: flavohem_like_fad_nad_binding; cd06184
335659012538	FAD binding pocket [chemical binding]; other site
335659012539	FAD binding motif [chemical binding]; other site
335659012540	phosphate binding motif [ion binding]; other site
335659012541	beta-alpha-beta structure motif; other site
335659012542	NAD binding pocket [chemical binding]; other site
335659012543	Heme binding  pocket [chemical binding]; other site
335659012544	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
335659012545	catalytic loop [active]
335659012546	iron binding site [ion binding]; other site
335659012547	Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388
335659012548	Na+/H+ antiporter 1; Region: Na_H_antiport_1; cl01133
335659012549	ergothioneine biosynthesis protein EgtC; Region: TIGR03442
335659012550	Glutamine amidotransferases class-II (Gn-AT)_YafJ-type.  YafJ is a glutamine amidotransferase-like protein of unknown function found in prokaryotes, eukaryotes and archaea.  YafJ has a conserved structural fold similar to those of other class II...; Region: YafJ; cd01908
335659012551	putative active site [active]
335659012552	putative dimer interface [polypeptide binding]; other site
335659012553	carboxylate-amine ligase; Provisional; Region: PRK13515
335659012554	carboxylate-amine ligase, YbdK family; Region: gshA_cyan_rel; TIGR02050
335659012555	Protein of unknown function (DUF3551); Region: DUF3551; pfam12071
335659012556	Glutathione-dependent formaldehyde dehydrogenase related proteins, child 1; Region: FDH_like_1; cd08283
335659012557	Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063
335659012558	NAD binding site [chemical binding]; other site
335659012559	catalytic Zn binding site [ion binding]; other site
335659012560	structural Zn binding site [ion binding]; other site
335659012561	Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596
335659012562	Manganese catalase, ferritin-like diiron-binding domain; Region: Mn_catalase; cd01051
335659012563	dimanganese center [ion binding]; other site
335659012564	YciF bacterial stress response protein, ferritin-like iron-binding domain; Region: YciF; cd07909
335659012565	metal binding site [ion binding]; metal-binding site
335659012566	dimerization interface [polypeptide binding]; other site
335659012567	glutathione reductase; Validated; Region: PRK06116
335659012568	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
335659012569	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
335659012570	Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852
335659012571	Uncharacterized protein conserved in bacteria (DUF2059); Region: DUF2059; pfam09832
335659012572	RPI_A: Ribose 5-phosphate isomerase type A (RPI_A) subfamily; RPI catalyzes the reversible conversion of ribose-5-phosphate to ribulose 5-phosphate, the first step of the non-oxidative branch of the pentose phosphate pathway. This reaction leads to the...; Region: RPI_A; cd01398
335659012573	tetramer (dimer of dimers) interface [polypeptide binding]; other site
335659012574	active site
335659012575	dimer interface [polypeptide binding]; other site
335659012576	phosphoglycolate phosphatase; Provisional; Region: PRK13222
335659012577	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
335659012578	motif II; other site
335659012579	molybdenum cofactor biosynthesis protein A; Reviewed; Region: moaA; PRK00164
335659012580	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
335659012581	FeS/SAM binding site; other site
335659012582	Molybdenum Cofactor Synthesis C; Region: Mob_synth_C; pfam06463
335659012583	TRAP-type mannitol/chloroaromatic compound transport system, small permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: FcbT2; COG4665
335659012584	TRAP-type mannitol/chloroaromatic compound transport system, large permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: FcbT3; COG4664
335659012585	DctM-like transporters; Region: DctM; pfam06808
335659012586	TRAP-type C4-dicarboxylate transport system, large permease component [Carbohydrate transport and metabolism]; Region: DctQ; cl17274
335659012587	heavy metal sensor kinase; Region: cztS_silS_copS; TIGR01386
335659012588	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
335659012589	dimer interface [polypeptide binding]; other site
335659012590	phosphorylation site [posttranslational modification]
335659012591	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
335659012592	ATP binding site [chemical binding]; other site
335659012593	Mg2+ binding site [ion binding]; other site
335659012594	G-X-G motif; other site
335659012595	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
335659012596	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
335659012597	active site
335659012598	phosphorylation site [posttranslational modification]
335659012599	intermolecular recognition site; other site
335659012600	dimerization interface [polypeptide binding]; other site
335659012601	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
335659012602	DNA binding site [nucleotide binding]
335659012603	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
335659012604	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
335659012605	EamA-like transporter family; Region: EamA; pfam00892
335659012606	TRAP-type C4-dicarboxylate transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: DctP; COG1638
335659012607	Bacterial extracellular solute-binding protein, family 7; Region: SBP_bac_7; cl15441
335659012608	Domain of unknown function DUF59; Region: DUF59; pfam01883
335659012609	Antiactivator of flagellar biosynthesis FleN, an ATPase [Cell motility]; Region: flhG; COG0455
335659012610	MRP (Multiple Resistance and pH adaptation) is a homologue of the Fer4_NifH superfamily. Like the other members of the superfamily, MRP contains a ATP-binding domain at the N-termini. It is found in bacteria as a membrane-spanning protein and functions...; Region: MRP-like; cd02037
335659012611	Walker A motif; other site
335659012612	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
335659012613	This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_9; cd07245
335659012614	dimer interface [polypeptide binding]; other site
335659012615	putative metal binding site [ion binding]; other site
335659012616	NAD(P) binding domain of amino acid dehydrogenase-like proteins; Region: NAD_bind_amino_acid_DH; cl17226
335659012617	3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084
335659012618	NAD(P) binding pocket [chemical binding]; other site
335659012619	6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599
335659012620	NHAD transporter family protein; Provisional; Region: PLN00137; cl17324
335659012621	Na+/H+ antiporter NhaD and related arsenite permeases [Inorganic ion transport and metabolism]; Region: ArsB; COG1055
335659012622	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
335659012623	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
335659012624	dimer interface [polypeptide binding]; other site
335659012625	phosphorylation site [posttranslational modification]
335659012626	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
335659012627	ATP binding site [chemical binding]; other site
335659012628	Mg2+ binding site [ion binding]; other site
335659012629	G-X-G motif; other site
335659012630	Protein of unknown function (DUF1289); Region: DUF1289; pfam06945
335659012631	Bacterial aspartate proteases, retropepsin-like protease family; Region: retropepsin_like_bacteria; cd05483
335659012632	catalytic motif [active]
335659012633	Catalytic residue [active]
335659012634	tRNA-dihydrouridine synthase A; Provisional; Region: PRK11815
335659012635	Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801
335659012636	FMN binding site [chemical binding]; other site
335659012637	active site
335659012638	catalytic residues [active]
335659012639	substrate binding site [chemical binding]; other site
335659012640	type I secretion membrane fusion protein, HlyD family; Region: type_I_hlyD; TIGR01843
335659012641	Periplasmic binding protein; Region: Peripla_BP_6; pfam13458
335659012642	Type I periplasmic binding component of active transport systems that are predicted be involved in anaerobic biodegradation of alkylbenzenes such as toluene and ethylbenzene; Region: PBP1_alkylbenzenes_like; cd06360
335659012643	putative ligand binding site [chemical binding]; other site
335659012644	AraC-like ligand binding domain; Region: AraC_binding; pfam02311
335659012645	AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207
335659012646	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
335659012647	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
335659012648	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
335659012649	Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582
335659012650	TM-ABC transporter signature motif; other site
335659012651	ABC-type branched-chain amino acid transport system, permease component [Amino acid transport and metabolism]; Region: LivM; COG4177
335659012652	Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581
335659012653	TM-ABC transporter signature motif; other site
335659012654	ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411
335659012655	ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219
335659012656	Walker A/P-loop; other site
335659012657	ATP binding site [chemical binding]; other site
335659012658	Q-loop/lid; other site
335659012659	ABC transporter signature motif; other site
335659012660	Walker B; other site
335659012661	D-loop; other site
335659012662	H-loop/switch region; other site
335659012663	ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410
335659012664	ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224
335659012665	Walker A/P-loop; other site
335659012666	ATP binding site [chemical binding]; other site
335659012667	Q-loop/lid; other site
335659012668	ABC transporter signature motif; other site
335659012669	Walker B; other site
335659012670	D-loop; other site
335659012671	H-loop/switch region; other site
335659012672	hypothetical protein; Provisional; Region: PRK02399
335659012673	Uncharacterized protein family (UPF0261); Region: UPF0261; pfam06792
335659012674	TIM-barrel signal transduction protein; Region: TIM-br_sig_trns; pfam09370
335659012675	Band_7_flotillin: a subgroup of the band 7 domain of flotillin (reggie) like proteins. This subgroup contains proteins similar to stomatin, prohibitin, flotillin, HlfK/C and podicin.  These two proteins are lipid raft-associated.  Individual proteins of...; Region: Band_7_flotillin; cd03399
335659012676	Pyrabactin resistance 1 (PYR1), PYR1-like (PYL), regulatory component of abscisic acid receptors (RCARs), and related proteins; Region: PYR_PYL_RCAR_like; cd07821
335659012677	putative hydrophobic ligand binding site [chemical binding]; other site
335659012678	protein interface [polypeptide binding]; other site
335659012679	gate; other site
335659012680	Pyrabactin resistance 1 (PYR1), PYR1-like (PYL), regulatory component of abscisic acid receptors (RCARs), and related proteins; Region: PYR_PYL_RCAR_like; cd07821
335659012681	putative hydrophobic ligand binding site [chemical binding]; other site
335659012682	protein interface [polypeptide binding]; other site
335659012683	gate; other site
335659012684	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM/CutM homologs [Energy production and conversion]; Region: CoxM; COG1319
335659012685	CO dehydrogenase flavoprotein C-terminal domain; Region: CO_deh_flav_C; pfam03450
335659012686	Aerobic-type carbon monoxide dehydrogenase, small subunit CoxS/CutS homologs [Energy production and conversion]; Region: CoxS; COG2080
335659012687	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
335659012688	catalytic loop [active]
335659012689	iron binding site [ion binding]; other site
335659012690	[2Fe-2S] binding domain; Region: Fer2_2; pfam01799
335659012691	Aerobic-type carbon monoxide dehydrogenase, large subunit CoxL/CutL homologs [Energy production and conversion]; Region: CoxL; COG1529
335659012692	Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; smart01008
335659012693	Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738
335659012694	Aerobic-type carbon monoxide dehydrogenase, large subunit CoxL/CutL homologs [Energy production and conversion]; Region: CoxL; COG1529
335659012695	Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738
335659012696	MoxR-like ATPases [General function prediction only]; Region: COG0714
335659012697	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
335659012698	ATP binding site [chemical binding]; other site
335659012699	Walker A motif; other site
335659012700	Walker B motif; other site
335659012701	arginine finger; other site
335659012702	Protein containing von Willebrand factor type A (vWA) domain [General function prediction only]; Region: CoxE; COG3552
335659012703	Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198
335659012704	metal ion-dependent adhesion site (MIDAS); other site
335659012705	Predicted metal-dependent hydrolase of the TIM-barrel fold [General function prediction only]; Region: COG3618
335659012706	Amidohydrolase; Region: Amidohydro_2; pfam04909
335659012707	Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849
335659012708	SMP-30/Gluconolaconase/LRE-like region; Region: SGL; pfam08450
335659012709	Isochorismatase family; Region: Isochorismatase; pfam00857
335659012710	Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cd00431
335659012711	catalytic triad [active]
335659012712	conserved cis-peptide bond; other site
335659012713	Flavodoxin-like fold; Region: Flavodoxin_2; pfam02525
335659012714	NADPH-dependent FMN reductase; Region: FMN_red; pfam03358
335659012715	ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224
335659012716	Walker A/P-loop; other site
335659012717	ATP binding site [chemical binding]; other site
335659012718	ABC transporter; Region: ABC_tran; pfam00005
335659012719	Q-loop/lid; other site
335659012720	ABC transporter signature motif; other site
335659012721	Walker B; other site
335659012722	D-loop; other site
335659012723	ABC-type branched-chain amino acid transport system, permease component [Amino acid transport and metabolism]; Region: LivM; COG4177
335659012724	Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581
335659012725	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
335659012726	Walker A/P-loop; other site
335659012727	L-alanine-DL-glutamate epimerase and related enzymes of enolase superfamily [Cell envelope biogenesis, outer membrane / General function prediction only]; Region: COG4948
335659012728	Mandelate racemase (MR)-like subfamily of the enolase superfamily. Enzymes of this subgroup share three conserved carboxylate ligands for the essential divalent metal ion (usually Mg2+), two aspartates and a glutamate, and conserved catalytic residues; Region: MR_like; cd03316
335659012729	active site pocket [active]
335659012730	tagatose 1,6-diphosphate aldolase; Reviewed; Region: PRK12858
335659012731	Ribokinase-like subgroup B.  Found in bacteria and plants, this subgroup is part of the ribokinase/pfkB superfamily.  Its oligomerization state is unknown at this time; Region: ribokinase_group_B; cd01945
335659012732	Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524
335659012733	substrate binding site [chemical binding]; other site
335659012734	ATP binding site [chemical binding]; other site
335659012735	glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650
335659012736	The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301
335659012737	Walker A/P-loop; other site
335659012738	ATP binding site [chemical binding]; other site
335659012739	Q-loop/lid; other site
335659012740	ABC transporter signature motif; other site
335659012741	Walker B; other site
335659012742	D-loop; other site
335659012743	H-loop/switch region; other site
335659012744	TOBE domain; Region: TOBE_2; pfam08402
335659012745	Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912
335659012746	Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063
335659012747	NAD(P) binding site [chemical binding]; other site
335659012748	ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395
335659012749	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
335659012750	dimer interface [polypeptide binding]; other site
335659012751	conserved gate region; other site
335659012752	putative PBP binding loops; other site
335659012753	ABC-ATPase subunit interface; other site
335659012754	ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555
335659012755	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
335659012756	dimer interface [polypeptide binding]; other site
335659012757	conserved gate region; other site
335659012758	putative PBP binding loops; other site
335659012759	ABC-ATPase subunit interface; other site
335659012760	Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416
335659012761	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547
335659012762	Transcriptional regulators [Transcription]; Region: PurR; COG1609
335659012763	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
335659012764	DNA binding site [nucleotide binding]
335659012765	domain linker motif; other site
335659012766	This group includes the ligand-binding domain of putative DNA transcription repressors which are highly similar to that of the repressor specific for gluconate (GntR), a member of the LacI-GalR family of bacterial transcription regulators; Region: PBP1_GntR_like_1; cd06273
335659012767	putative dimerization interface [polypeptide binding]; other site
335659012768	putative ligand binding site [chemical binding]; other site
335659012769	3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557
335659012770	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
335659012771	NAD(P) binding site [chemical binding]; other site
335659012772	active site
335659012773	Arabinose-binding domain of AraC transcription regulator, N-term; Region: Arabinose_bd; pfam12625
335659012774	AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207
335659012775	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
335659012776	Amino acid permease; Region: AA_permease; pfam00324
335659012777	tyramine oxidase; Provisional; Region: tynA; PRK11504
335659012778	Copper amine oxidase, N2 domain; Region: Cu_amine_oxidN2; pfam02727
335659012779	Copper amine oxidase, N3 domain; Region: Cu_amine_oxidN3; pfam02728
335659012780	Copper amine oxidase, enzyme domain; Region: Cu_amine_oxid; pfam01179
335659012781	UreD urease accessory protein; Region: UreD; cl00530
335659012782	The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203
335659012783	urease subunit alpha; Reviewed; Region: ureC; PRK13308
335659012784	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
335659012785	active site
335659012786	bifunctional urease subunit gamma/beta; Reviewed; Region: PRK13192
335659012787	Urease gamma-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, archaea, fungi and plants. Their primary role is to allow the use...; Region: Urease_gamma; cd00390
335659012788	alpha-gamma subunit interface [polypeptide binding]; other site
335659012789	beta-gamma subunit interface [polypeptide binding]; other site
335659012790	Urease beta-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, archaea, fungi and plants. Their primary role is to allow the use of...; Region: Urease_beta; cd00407
335659012791	gamma-beta subunit interface [polypeptide binding]; other site
335659012792	alpha-beta subunit interface [polypeptide binding]; other site
335659012793	Urease accessory protein UreF [Posttranslational modification, protein turnover, chaperones]; Region: UreF; COG0830
335659012794	UreF; Region: UreF; pfam01730
335659012795	urease accessory protein UreE; Provisional; Region: ureE; PRK13261
335659012796	UreE urease accessory protein. UreE is a metallochaperone assisting the insertion of a Ni2+ ion in the active site of urease, an important step in the in vivo assembly of urease, an enzyme that hydrolyses urea into ammonia and carbamic acid. The...; Region: UreE; cl03727
335659012797	dimer interface [polypeptide binding]; other site
335659012798	catalytic residues [active]
335659012799	Antibiotic biosynthesis monooxygenase; Region: ABM; cl10022
335659012800	amidase; Provisional; Region: PRK07235
335659012801	Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154
335659012802	ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224
335659012803	urea ABC transporter, ATP-binding protein UrtE; Region: urea_trans_UrtE; TIGR03410
335659012804	Walker A/P-loop; other site
335659012805	ATP binding site [chemical binding]; other site
335659012806	Q-loop/lid; other site
335659012807	ABC transporter signature motif; other site
335659012808	Walker B; other site
335659012809	D-loop; other site
335659012810	H-loop/switch region; other site
335659012811	urea ABC transporter, ATP-binding protein UrtD; Region: urea_trans_UrtD; TIGR03411
335659012812	ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219
335659012813	Walker A/P-loop; other site
335659012814	ATP binding site [chemical binding]; other site
335659012815	Q-loop/lid; other site
335659012816	ABC transporter signature motif; other site
335659012817	Walker B; other site
335659012818	D-loop; other site
335659012819	H-loop/switch region; other site
335659012820	ABC-type branched-chain amino acid transport system, permease component [Amino acid transport and metabolism]; Region: LivM; COG4177
335659012821	Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581
335659012822	TM-ABC transporter signature motif; other site
335659012823	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
335659012824	Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582
335659012825	TM-ABC transporter signature motif; other site
335659012826	Periplasmic binding protein; Region: Peripla_BP_6; pfam13458
335659012827	Periplasmic component (FmdD) of an active transport system for short-chain amides and urea (FmdDEF); Region: PBP1_Amide_Urea_BP_like; cd06356
335659012828	putative ligand binding site [chemical binding]; other site
335659012829	Periplasmic binding protein; Region: Peripla_BP_6; pfam13458
335659012830	Type I periplasmic-binding protein of the nitrile hydratase (NHase) system that selectively converts nitriles to corresponding amides; Region: PBP1_NHase; cd06358
335659012831	putative ligand binding site [chemical binding]; other site
335659012832	helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347
335659012833	MarR family; Region: MarR; pfam01047
335659012834	allantoate amidohydrolase; Reviewed; Region: PRK09290
335659012835	M20 Peptidase beta-alanine synthase, an amidohydrolase; Region: M20_bAS; cd03884
335659012836	active site
335659012837	metal binding site [ion binding]; metal-binding site
335659012838	dimer interface [polypeptide binding]; other site
335659012839	4-aminobutyrate aminotransferase and related aminotransferases [Amino acid transport and metabolism]; Region: GabT; COG0160
335659012840	Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610
335659012841	inhibitor-cofactor binding pocket; inhibition site
335659012842	pyridoxal 5'-phosphate binding site [chemical binding]; other site
335659012843	catalytic residue [active]
335659012844	Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349
335659012845	DeoR-like helix-turn-helix domain; Region: HTH_DeoR; pfam08220
335659012846	DeoR C terminal sensor domain; Region: DeoRC; pfam00455
335659012847	DNA-binding transcriptional activator FeaR; Provisional; Region: PRK09685
335659012848	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
335659012849	Predominantly bacterial family of Mg++ dependend phosphatases, related to inositol monophosphatases. These enzymes may dephosphorylate fructose-1,6-bisphosphate, inositol monophospate, 3'-phosphoadenosine-5'-phosphate,  or similar substrates; Region: Bacterial_IMPase_like_1; cd01641
335659012850	Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483
335659012851	active site
335659012852	Choline Kinase (ChoK). The ChoK subfamily is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs), RIO kinases, actin-fragmin kinase (AFK), and...; Region: ChoK; cd05151
335659012853	Phosphotransferase enzyme family; Region: APH; pfam01636
335659012854	active site
335659012855	ATP binding site [chemical binding]; other site
335659012856	substrate binding site [chemical binding]; other site
335659012857	dimer interface [polypeptide binding]; other site
335659012858	Phosphotransferase enzyme family; Region: APH; pfam01636
335659012859	Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270
335659012860	active site
335659012861	ATP binding site [chemical binding]; other site
335659012862	substrate binding site [chemical binding]; other site
335659012863	amidase; Provisional; Region: PRK07042
335659012864	Amidase; Region: Amidase; cl11426
335659012865	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
335659012866	This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587
335659012867	active site
335659012868	metal binding site [ion binding]; metal-binding site
335659012869	Epoxide hydrolase N terminus; Region: EHN; pfam06441
335659012870	Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596
335659012871	short chain dehydrogenase; Provisional; Region: PRK06180
335659012872	17beta hydroxysteroid dehydrogenase-like, classical (c) SDRs; Region: 17beta-HSD-like_SDR_c; cd05374
335659012873	NADP binding site [chemical binding]; other site
335659012874	active site
335659012875	steroid binding site; other site
335659012876	Transcriptional regulator [Transcription]; Region: LysR; COG0583
335659012877	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
335659012878	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466
335659012879	dimerization interface [polypeptide binding]; other site
335659012880	ATPase components of various ABC-type transport systems, contain duplicated ATPase [General function prediction only]; Region: COG1123
335659012881	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
335659012882	Walker A/P-loop; other site
335659012883	ATP binding site [chemical binding]; other site
335659012884	Q-loop/lid; other site
335659012885	ABC transporter signature motif; other site
335659012886	Walker B; other site
335659012887	D-loop; other site
335659012888	H-loop/switch region; other site
335659012889	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
335659012890	Walker A/P-loop; other site
335659012891	ATP binding site [chemical binding]; other site
335659012892	Q-loop/lid; other site
335659012893	ABC transporter signature motif; other site
335659012894	Walker B; other site
335659012895	D-loop; other site
335659012896	H-loop/switch region; other site
335659012897	oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727
335659012898	nickel transporter permease NikC; Provisional; Region: nikC; PRK10417
335659012899	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
335659012900	dimer interface [polypeptide binding]; other site
335659012901	conserved gate region; other site
335659012902	putative PBP binding loops; other site
335659012903	ABC-ATPase subunit interface; other site
335659012904	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601
335659012905	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
335659012906	dimer interface [polypeptide binding]; other site
335659012907	conserved gate region; other site
335659012908	putative PBP binding loops; other site
335659012909	ABC-ATPase subunit interface; other site
335659012910	The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cd00995
335659012911	Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496
335659012912	Predicted sugar phosphatases of the HAD superfamily [Carbohydrate transport and metabolism]; Region: NagD; COG0647
335659012913	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
335659012914	active site
335659012915	motif I; other site
335659012916	motif II; other site
335659012917	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
335659012918	putative molybdenum utilization protein ModD; Region: modD; TIGR01334
335659012919	Phosphoribosyltransferase (PRTase) type II; This family contains two enzymes that play an important role in NAD production by either allowing quinolinic acid (QA) , quinolinate phosphoribosyl transferase (QAPRTase), or nicotinic acid (NA), nicotinate...; Region: PRTase_typeII; cl17275
335659012920	active site
335659012921	ABC-type molybdate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: ModA; COG0725
335659012922	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199
335659012923	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
335659012924	dimer interface [polypeptide binding]; other site
335659012925	conserved gate region; other site
335659012926	putative PBP binding loops; other site
335659012927	ABC-ATPase subunit interface; other site
335659012928	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
335659012929	molybdenum ABC transporter, ATP-binding protein; Region: modC_ABC; TIGR02142
335659012930	Walker A/P-loop; other site
335659012931	ATP binding site [chemical binding]; other site
335659012932	Q-loop/lid; other site
335659012933	ABC transporter signature motif; other site
335659012934	Walker B; other site
335659012935	D-loop; other site
335659012936	H-loop/switch region; other site
335659012937	TOBE domain; Region: TOBE; cl01440
335659012938	Protein of unknown function (DUF2478); Region: DUF2478; pfam10649
335659012939	Molybdopterin-binding protein [Coenzyme metabolism]; Region: MopI; COG3585
335659012940	Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450
335659012941	Peroxiredoxin (PRX) family, Typical 2-Cys PRX subfamily; PRXs are thiol-specific antioxidant (TSA) proteins, which confer a protective role in cells through its peroxidase activity by reducing hydrogen peroxide, peroxynitrite, and organic hydroperoxides; Region: PRX_Typ2cys; cd03015
335659012942	dimer interface [polypeptide binding]; other site
335659012943	decamer (pentamer of dimers) interface [polypeptide binding]; other site
335659012944	catalytic triad [active]
335659012945	peroxidatic and resolving cysteines [active]
335659012946	alkylhydroperoxidase, AhpD family; Region: ahpD; TIGR00777
335659012947	Carboxymuconolactone decarboxylase family; Region: CMD; pfam02627
335659012948	Ferredoxin-like protein [Energy production and conversion]; Region: FixX; COG2440
335659012949	oxidoreductase; Provisional; Region: PRK10015
335659012950	Electron transfer flavoprotein, alpha subunit [Energy production and conversion]; Region: FixB; COG2025
335659012951	The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_alpha; cd01715
335659012952	Electron transfer flavoprotein FAD-binding domain; Region: ETF_alpha; pfam00766
335659012953	The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_beta; cd01714
335659012954	Ligand binding site [chemical binding]; other site
335659012955	Electron transfer flavoprotein domain; Region: ETF; pfam01012
335659012956	nitrogenase stabilizing/protective protein; Provisional; Region: nifW; PRK00810
335659012957	Serine acetyltransferase, N-terminal; Region: SATase_N; cl05762
335659012958	Serine acetyltransferase [Amino acid transport and metabolism]; Region: CysE; COG1045
335659012959	Serine acetyltransferase (SAT): SAT catalyzes the CoA-dependent acetylation of the side chain hydroxyl group of L-serine to form O-acetylserine, as the first step of a two-step biosynthetic pathway in bacteria and plants leading to the formation of...; Region: LbH_SAT; cd03354
335659012960	trimer interface [polypeptide binding]; other site
335659012961	active site
335659012962	substrate binding site [chemical binding]; other site
335659012963	CoA binding site [chemical binding]; other site
335659012964	homocitrate synthase NifV; Region: nifV_homocitr; TIGR02660
335659012965	Streptomyces rubellomurinus FrbC and related proteins, catalytic TIM barrel domain; Region: DRE_TIM_NifV; cd07939
335659012966	active site
335659012967	catalytic residues [active]
335659012968	metal binding site [ion binding]; metal-binding site
335659012969	Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153
335659012970	metal binding site 2 [ion binding]; metal-binding site
335659012971	putative DNA binding helix; other site
335659012972	metal binding site 1 [ion binding]; metal-binding site
335659012973	dimer interface [polypeptide binding]; other site
335659012974	NifQ; Region: NifQ; pfam04891
335659012975	nitrogenase reductase; Reviewed; Region: nifH; PRK13234
335659012976	NifH gene encodes component II (iron protein) of nitrogenase. Nitrogenase is responsible for the biological nitrogen fixation, i.e. reduction of molecular nitrogen to ammonia. NifH consists of two oxygen-sensitive metallosulfur proteins: the...; Region: NifH; cd02040
335659012977	Nucleotide-binding sites [chemical binding]; other site
335659012978	Walker A motif; other site
335659012979	Switch I region of nucleotide binding site; other site
335659012980	Fe4S4 binding sites [ion binding]; other site
335659012981	Switch II region of nucleotide binding site; other site
335659012982	Response regulator receiver domain; Region: Response_reg; pfam00072
335659012983	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
335659012984	active site
335659012985	phosphorylation site [posttranslational modification]
335659012986	intermolecular recognition site; other site
335659012987	dimerization interface [polypeptide binding]; other site
335659012988	Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388
335659012989	Thioredoxin (TRX)-like [2Fe-2S] Ferredoxin (Fd) family; composed of [2Fe-2S] Fds with a TRX fold (TRX-like Fds) and proteins containing domains similar to TRX-like Fd including formate dehydrogenases, NAD-reducing hydrogenases and the subunit E of NADH:...; Region: TRX_Fd_family; cd02980
335659012990	dimer interface [polypeptide binding]; other site
335659012991	[2Fe-2S] cluster binding site [ion binding]; other site
335659012992	Glutaredoxin (GRX) family, PKC-interacting cousin of TRX (PICOT)-like subfamily; composed of PICOT and GRX-PICOT-like proteins. The non-PICOT members of this family contain only the GRX-like domain, whereas PICOT contains an N-terminal TRX-like domain...; Region: GRX_PICOT_like; cd03028
335659012993	putative GSH binding site [chemical binding]; other site
335659012994	catalytic residues [active]
335659012995	Stress-induced morphogen (activity unknown) [Signal transduction mechanisms]; Region: BolA; COG0271
335659012996	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429
335659012997	binding surface
335659012998	TPR motif; other site
335659012999	FeS assembly SUF system protein; Region: SUF_assoc; TIGR02945
335659013000	Dienelactone hydrolase and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG0412
335659013001	Truncated hemoglobins (trHbs) are a family of oxygen-binding heme proteins found in cyanobacteria, eubacteria, unicellular eukaryotes, and plants. The truncated hemoglobins have a characteristic two-over-two alpha helical folding pattern that is distinct...; Region: Trunc_globin; cd00454
335659013002	apolar tunnel; other site
335659013003	heme binding site [chemical binding]; other site
335659013004	dimerization interface [polypeptide binding]; other site
335659013005	Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cd03467
335659013006	iron-sulfur cluster [ion binding]; other site
335659013007	[2Fe-2S] cluster binding site [ion binding]; other site
335659013008	The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203
335659013009	Ferredoxin [Energy production and conversion]; Region: Fdx; COG0633
335659013010	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
335659013011	catalytic loop [active]
335659013012	iron binding site [ion binding]; other site
335659013013	Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WecE; COG0399
335659013014	3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616
335659013015	inhibitor-cofactor binding pocket; inhibition site
335659013016	pyridoxal 5'-phosphate binding site [chemical binding]; other site
335659013017	catalytic residue [active]
335659013018	Protein of unknown function (DUF3024); Region: DUF3024; pfam11225
335659013019	NifZ domain; Region: NifZ; pfam04319
335659013020	NifZ domain; Region: NifZ; pfam04319
335659013021	LRV protein FeS4 cluster; Region: LRV_FeS; pfam05484
335659013022	Fe-S cluster assembly scaffold protein [Posttranslational modification, protein turnover, chaperones]; Region: sufA; COG0316
335659013023	4Fe-4S dicluster domain; Region: Fer4_7; pfam12838
335659013024	nitrogenase cofactor biosynthesis protein NifB; Region: nifB; TIGR01290
335659013025	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
335659013026	FeS/SAM binding site; other site
335659013027	NifB belongs to a family of iron-molybdenum cluster-binding proteins that includes NifX, and NifY, all of which are involved in the synthesis of an iron-molybdenum cofactor (FeMo-co) that binds the active site of the dinitrogenase enzyme as part of...; Region: NifB; cd00852
335659013028	SIR2-like domain; Region: SIR2_2; pfam13289
335659013029	NifT/FixU protein; Region: NifT; pfam06988
335659013030	Cysteine sulfinate desulfinase/cysteine desulfurase and related enzymes [Amino acid transport and metabolism]; Region: NifS; COG1104
335659013031	cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402
335659013032	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
335659013033	catalytic residue [active]
335659013034	NifU-like domain; Region: NifU; pfam01106
335659013035	Iron-sulfur cluster assembly accessory protein; Region: TIGR00049
335659013036	Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cd03467
335659013037	iron-sulfur cluster [ion binding]; other site
335659013038	[2Fe-2S] cluster binding site [ion binding]; other site
335659013039	Hemimethylated DNA-binding protein YccV like; Region: YccV-like; smart00992
335659013040	ferredoxin III, nif-specific; Region: fdxN_nitrog; TIGR02936
335659013041	Rop-like; Region: Rop-like; pfam05082
335659013042	probable nitrogen fixation protein; Region: TIGR02935
335659013043	NifX belongs to a family of iron-molybdenum cluster-binding proteins that includes NifB,  and NifY, all of which are involved in the synthesis of an iron-molybdenum cofactor (FeMo-co) that binds the active site of the dinitrogenase enzyme.  The protein...; Region: NifX; cd00853
335659013044	Nitrogenase_nifN1: A subgroup of the NifN subunit of the NifEN complex: NifN forms an alpha2beta2 tetramer with NifE.  NifN and nifE are structurally homologous to nitrogenase MoFe protein beta and alpha subunits respectively.  NifEN participates in the...; Region: Nitrogenase_NifN_1; cd01966
335659013045	Nitrogenase component 1 type Oxidoreductase; Region: Oxidored_nitro; pfam00148
335659013046	nitrogenase molybdenum-iron cofactor biosynthesis protein NifE; Region: nifE; TIGR01283
335659013047	Nitrogenase_NifE_I: a subgroup of the NifE subunit of the NifEN complex: NifE forms an alpha2beta2 tetramer with NifN.  NifE and NifN are structurally homologous to nitrogenase MoFe protein alpha and beta subunits respectively.  NifEN participates in the...; Region: Nitrogenase_NifE_I; cd01968
335659013048	BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324
335659013049	nitrogenase molybdenum-iron protein beta chain; Region: nifK; TIGR01286
335659013050	Domain of unknown function (DUF3364); Region: DUF3364; pfam11844
335659013051	Nitrogenase_MoFe_beta: Nitrogenase MoFe protein, beta subunit. The nitrogenase enzyme catalyzes the ATP-dependent reduction of dinitrogen to ammonia. The Molybdenum (Mo-) nitrogenase is the most widespread and best characterized of these systems; Region: Nitrogenase_MoFe_beta; cd01974
335659013052	MoFe protein beta/alpha subunit interactions; other site
335659013053	Beta subunit P cluster binding residues; other site
335659013054	MoFe protein beta subunit/Fe protein contacts; other site
335659013055	MoFe protein dimer/ dimer interactions; other site
335659013056	Nitrogenase molybdenum-iron protein, alpha and beta chains [Energy production and conversion]; Region: NifD; COG2710
335659013057	Nitrogenase_MoFe_alpha_II: Nitrogenase MoFe protein, beta subunit. A group of proteins similar to the alpha subunit of the MoFe protein of the molybdenum (Mo-) nitrogenase. The nitrogenase enzyme catalyzes the ATP-dependent reduction of dinitrogen to...; Region: Nitrogenase_MoFe_alpha; cd01976
335659013058	MoFe protein alpha/beta subunit interactions; other site
335659013059	Alpha subunit P cluster binding residues; other site
335659013060	FeMoco binding residues [chemical binding]; other site
335659013061	MoFe protein alpha subunit/Fe protein contacts; other site
335659013062	MoFe protein dimer/ dimer interactions; other site
335659013063	nitrogenase reductase; Reviewed; Region: nifH; PRK13234
335659013064	NifH gene encodes component II (iron protein) of nitrogenase. Nitrogenase is responsible for the biological nitrogen fixation, i.e. reduction of molecular nitrogen to ammonia. NifH consists of two oxygen-sensitive metallosulfur proteins: the...; Region: NifH; cd02040
335659013065	Nucleotide-binding sites [chemical binding]; other site
335659013066	Walker A motif; other site
335659013067	Switch I region of nucleotide binding site; other site
335659013068	Fe4S4 binding sites [ion binding]; other site
335659013069	Switch II region of nucleotide binding site; other site
335659013070	Response regulator receiver domain; Region: Response_reg; pfam00072
335659013071	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
335659013072	active site
335659013073	intermolecular recognition site; other site
335659013074	dimerization interface [polypeptide binding]; other site
335659013075	Cysteine desulfurase SufE subunit [Posttranslational modification, protein turnover, chaperones]; Region: sufE; COG2166
335659013076	NifZ domain; Region: NifZ; pfam04319
335659013077	Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520
335659013078	Cysteine desulfurase (SufS)-like. This family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to cysteine desulfurase (SufS) and selenocysteine lyase. SufS...; Region: SufS_like; cd06453
335659013079	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
335659013080	catalytic residue [active]
335659013081	FeS assembly protein SufD; Region: sufD; TIGR01981
335659013082	Uncharacterized protein family (UPF0051); Region: UPF0051; pfam01458
335659013083	FeS assembly ATPase SufC; Region: sufC; TIGR01978
335659013084	ABC-type transport system involved in Fe-S cluster assembly, ATPase component; Region: ABC_FeS_Assembly; cd03217
335659013085	Walker A/P-loop; other site
335659013086	ATP binding site [chemical binding]; other site
335659013087	Q-loop/lid; other site
335659013088	ABC transporter signature motif; other site
335659013089	Walker B; other site
335659013090	D-loop; other site
335659013091	H-loop/switch region; other site
335659013092	cysteine desulfurase activator complex subunit SufB; Provisional; Region: PRK11814
335659013093	putative ABC transporter; Region: ycf24; CHL00085
335659013094	hypothetical protein; Provisional; Region: PRK13795
335659013095	Nif-specific regulatory protein; Region: nifA; TIGR01817
335659013096	Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065
335659013097	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
335659013098	Walker A motif; other site
335659013099	ATP binding site [chemical binding]; other site
335659013100	Walker B motif; other site
335659013101	arginine finger; other site
335659013102	Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954
335659013103	classical (c) SDRs; Region: SDR_c; cd05233
335659013104	NAD(P) binding site [chemical binding]; other site
335659013105	active site
335659013106	selenium-dependent molybdenum hydroxylase system protein, YqeB family; Region: matur_yqeB; TIGR03309
335659013107	Transcription-repair coupling factor (superfamily II helicase) [DNA replication, recombination, and repair / Transcription]; Region: Mfd; COG1197
335659013108	CarD-like/TRCF domain; Region: CarD_CdnL_TRCF; pfam02559
335659013109	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
335659013110	ATP binding site [chemical binding]; other site
335659013111	putative Mg++ binding site [ion binding]; other site
335659013112	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
335659013113	nucleotide binding region [chemical binding]; other site
335659013114	ATP-binding site [chemical binding]; other site
335659013115	This domain is found in proteins necessary for strand-specific repair in DNA such as TRCF in Escherichia coli; Region: TRCF; smart00982
335659013116	Heme-dependent peroxidases similar to plant peroxidases; Region: plant_peroxidase_like; cl00196
335659013117	Protein of unknown function (DUF3750); Region: DUF3750; pfam12570
335659013118	ABC-type metal ion transport system, periplasmic component/surface antigen [Inorganic ion transport and metabolism]; Region: NlpA; COG1464
335659013119	NLPA lipoprotein; Region: Lipoprotein_9; pfam03180
335659013120	Protein involved in cellulose biosynthesis (CelD) [Cell envelope biogenesis, outer membrane]; Region: COG5653
335659013121	Acetyltransferase (GNAT) domain; Region: Acetyltransf_6; pfam13480
335659013122	ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314
335659013123	Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326
335659013124	Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244
335659013125	This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801
335659013126	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
335659013127	Glycosyl hydrolase families: GH43, GH62, GH32, GH68; Region: GH43_62_32_68; cl14647
335659013128	3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653
335659013129	classical (c) SDRs; Region: SDR_c; cd05233
335659013130	NAD(P) binding site [chemical binding]; other site
335659013131	active site
335659013132	Predicted amidohydrolase [General function prediction only]; Region: COG0388
335659013133	First nitrilase domain of an uncharacterized subgroup of the nitrilase superfamily (putative class 13 nitrilases); Region: nitrilase_1_R1; cd07578
335659013134	putative active site [active]
335659013135	catalytic triad [active]
335659013136	putative dimer interface [polypeptide binding]; other site
335659013137	Second nitrilase domain of an uncharacterized subgroup of the nitrilase superfamily (putative class 13 nitrilases); Region: nitrilase_1_R2; cd07579
335659013138	Predicted amidohydrolase [General function prediction only]; Region: COG0388
335659013139	putative active site [active]
335659013140	catalytic triad [active]
335659013141	putative dimer interface [polypeptide binding]; other site
335659013142	Predicted acetamidase/formamidase [Energy production and conversion]; Region: COG2421
335659013143	ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410
335659013144	ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224
335659013145	Walker A/P-loop; other site
335659013146	ATP binding site [chemical binding]; other site
335659013147	Q-loop/lid; other site
335659013148	ABC transporter signature motif; other site
335659013149	Walker B; other site
335659013150	D-loop; other site
335659013151	H-loop/switch region; other site
335659013152	urea ABC transporter, ATP-binding protein UrtD; Region: urea_trans_UrtD; TIGR03411
335659013153	ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219
335659013154	Walker A/P-loop; other site
335659013155	ATP binding site [chemical binding]; other site
335659013156	Q-loop/lid; other site
335659013157	ABC transporter signature motif; other site
335659013158	Walker B; other site
335659013159	D-loop; other site
335659013160	H-loop/switch region; other site
335659013161	ABC-type branched-chain amino acid transport system, permease component [Amino acid transport and metabolism]; Region: LivM; COG4177
335659013162	Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581
335659013163	TM-ABC transporter signature motif; other site
335659013164	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
335659013165	Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582
335659013166	TM-ABC transporter signature motif; other site
335659013167	Periplasmic binding protein; Region: Peripla_BP_6; pfam13458
335659013168	Periplasmic component (FmdD) of an active transport system for short-chain amides and urea (FmdDEF); Region: PBP1_Amide_Urea_BP_like; cd06356
335659013169	putative ligand binding site [chemical binding]; other site
335659013170	ANTAR domain; Region: ANTAR; pfam03861
335659013171	Periplasmic binding domain of amidase (AmiC) that belongs to the type I periplasmic binding fold protein family; Region: PBP1_AmiC; cd06357
335659013172	Periplasmic binding protein; Region: Peripla_BP_6; pfam13458
335659013173	ligand binding site [chemical binding]; other site
335659013174	regulator interaction site; other site
335659013175	Transcriptional regulator [Transcription]; Region: LysR; COG0583
335659013176	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
335659013177	The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422
335659013178	putative effector binding pocket; other site
335659013179	dimerization interface [polypeptide binding]; other site
335659013180	Stress responsive A/B Barrel Domain; Region: Dabb; smart00886
335659013181	Alcohol dehydrogenase, class IV [Energy production and conversion]; Region: EutG; COG1454
335659013182	Maleylacetate reductase is involved in many aromatic compounds degradation pathways of aerobic microbes; Region: MAR; cd08177
335659013183	active site
335659013184	dimer interface [polypeptide binding]; other site
335659013185	metal binding site [ion binding]; metal-binding site
335659013186	hypothetical protein; Provisional; Region: PRK08204
335659013187	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
335659013188	active site
335659013189	3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084
335659013190	6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599
335659013191	Hydroxyquinol 1,2-dioxygenase (1,2-HQD) catalyzes the ring cleavage of hydroxyquinol (1,2,4-trihydroxybenzene), a intermediate in the degradation of a large variety of aromatic compounds including some polychloro- and nitroaromatic pollutants, to form...; Region: 1,2-HQD; cd03461
335659013192	chlorocatechol 1,2-dioxygenase; Region: chlorocat_1_2; TIGR02465
335659013193	dimer interface [polypeptide binding]; other site
335659013194	active site
335659013195	FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277
335659013196	FAD binding domain; Region: FAD_binding_4; pfam01565
335659013197	ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129
335659013198	First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216
335659013199	Walker A/P-loop; other site
335659013200	ATP binding site [chemical binding]; other site
335659013201	Q-loop/lid; other site
335659013202	ABC transporter signature motif; other site
335659013203	Walker B; other site
335659013204	D-loop; other site
335659013205	H-loop/switch region; other site
335659013206	Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215
335659013207	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
335659013208	Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579
335659013209	TM-ABC transporter signature motif; other site
335659013210	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
335659013211	Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579
335659013212	TM-ABC transporter signature motif; other site
335659013213	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: RbsB; COG1879
335659013214	Periplasmic sugar-binding domain of active transport systems that are members of the type I periplasmic binding protein (PBP1) superfamily; Region: PBP1_ABC_sugar_binding_like; cd01536
335659013215	ligand binding site [chemical binding]; other site
335659013216	YciI-like protein; Reviewed; Region: PRK12863
335659013217	ABC-type oligopeptide transport system, ATPase component [Amino acid transport and metabolism]; Region: AppF; COG4608
335659013218	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
335659013219	Walker A/P-loop; other site
335659013220	ATP binding site [chemical binding]; other site
335659013221	Q-loop/lid; other site
335659013222	ABC transporter signature motif; other site
335659013223	Walker B; other site
335659013224	D-loop; other site
335659013225	H-loop/switch region; other site
335659013226	oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727
335659013227	ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444
335659013228	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
335659013229	Walker A/P-loop; other site
335659013230	ATP binding site [chemical binding]; other site
335659013231	Q-loop/lid; other site
335659013232	ABC transporter signature motif; other site
335659013233	Walker B; other site
335659013234	D-loop; other site
335659013235	H-loop/switch region; other site
335659013236	oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727
335659013237	nickel ABC transporter, permease subunit NikC; Region: nickel_nikC; TIGR02790
335659013238	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
335659013239	dimer interface [polypeptide binding]; other site
335659013240	conserved gate region; other site
335659013241	putative PBP binding loops; other site
335659013242	ABC-ATPase subunit interface; other site
335659013243	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601
335659013244	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
335659013245	dimer interface [polypeptide binding]; other site
335659013246	conserved gate region; other site
335659013247	ABC-ATPase subunit interface; other site
335659013248	ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747
335659013249	The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_16; cd08502
335659013250	ATPase components of various ABC-type transport systems, contain duplicated ATPase [General function prediction only]; Region: COG1123
335659013251	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
335659013252	Walker A/P-loop; other site
335659013253	ATP binding site [chemical binding]; other site
335659013254	Q-loop/lid; other site
335659013255	ABC transporter signature motif; other site
335659013256	Walker B; other site
335659013257	D-loop; other site
335659013258	H-loop/switch region; other site
335659013259	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097
335659013260	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
335659013261	Walker A/P-loop; other site
335659013262	ATP binding site [chemical binding]; other site
335659013263	Q-loop/lid; other site
335659013264	ABC transporter signature motif; other site
335659013265	Walker B; other site
335659013266	D-loop; other site
335659013267	H-loop/switch region; other site
335659013268	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097
335659013269	D-ala-D-ala transporter subunit; Provisional; Region: PRK09881
335659013270	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
335659013271	dimer interface [polypeptide binding]; other site
335659013272	conserved gate region; other site
335659013273	putative PBP binding loops; other site
335659013274	ABC-ATPase subunit interface; other site
335659013275	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601
335659013276	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
335659013277	dimer interface [polypeptide binding]; other site
335659013278	conserved gate region; other site
335659013279	putative PBP binding loops; other site
335659013280	ABC-ATPase subunit interface; other site
335659013281	The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_7; cd08512
335659013282	Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496
335659013283	Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072
335659013284	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
335659013285	short chain dehydrogenase; Provisional; Region: PRK06138
335659013286	classical (c) SDRs; Region: SDR_c; cd05233
335659013287	NAD(P) binding site [chemical binding]; other site
335659013288	active site
335659013289	Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451
335659013290	extended (e) SDRs; Region: SDR_e; cd08946
335659013291	NAD(P) binding site [chemical binding]; other site
335659013292	active site
335659013293	substrate binding site [chemical binding]; other site
335659013294	dihydropyrimidinase; Provisional; Region: PRK13404
335659013295	D-hydantoinases (D-HYD) also called dihydropyrimidases (DHPase) and related proteins; DHPases are a family of enzymes that catalyze the reversible hydrolytic ring opening of the amide bond in five- or six-membered cyclic diamides, like dihydropyrimidine...; Region: D-HYD; cd01314
335659013296	tetramer interface [polypeptide binding]; other site
335659013297	active site
335659013298	Asp/Glu/Hydantoin racemase; Region: Asp_Glu_race; cl00518
335659013299	Conserved protein/domain typically associated with flavoprotein oxygenases, DIM6/NTAB family [General function prediction only]; Region: COG1853
335659013300	N-carbamyl-D-amino acid amidohydrolase (DCase, class 6 nitrilases); Region: DCase; cd07569
335659013301	Predicted amidohydrolase [General function prediction only]; Region: COG0388
335659013302	tetramer interface [polypeptide binding]; other site
335659013303	active site
335659013304	catalytic triad [active]
335659013305	dimer interface [polypeptide binding]; other site
335659013306	long-chain-fatty-acid--CoA ligase; Validated; Region: PRK08314
335659013307	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
335659013308	Putative long-chain fatty acid CoA ligase; Region: LC_FACS_like; cd05935
335659013309	acyl-activating enzyme (AAE) consensus motif; other site
335659013310	acyl-activating enzyme (AAE) consensus motif; other site
335659013311	putative AMP binding site [chemical binding]; other site
335659013312	putative active site [active]
335659013313	putative CoA binding site [chemical binding]; other site
335659013314	Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610
335659013315	4-aminobutyrate aminotransferase and related aminotransferases [Amino acid transport and metabolism]; Region: GabT; COG0160
335659013316	inhibitor-cofactor binding pocket; inhibition site
335659013317	pyridoxal 5'-phosphate binding site [chemical binding]; other site
335659013318	catalytic residue [active]
335659013319	N-methylhydantoinase B/acetone carboxylase, alpha subunit [Amino acid transport and metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: HyuB; COG0146
335659013320	Hydantoinase B/oxoprolinase; Region: Hydantoinase_B; pfam02538
335659013321	N-methylhydantoinase A/acetone carboxylase, beta subunit [Amino acid transport and metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: HyuA; COG0145
335659013322	Hydantoinase/oxoprolinase N-terminal region; Region: Hydant_A_N; pfam05378
335659013323	Hydantoinase/oxoprolinase; Region: Hydantoinase_A; pfam01968
335659013324	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167
335659013325	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
335659013326	DNA-binding site [nucleotide binding]; DNA binding site
335659013327	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
335659013328	pyridoxal 5'-phosphate binding site [chemical binding]; other site
335659013329	homodimer interface [polypeptide binding]; other site
335659013330	catalytic residue [active]
335659013331	dihydropyrimidinase; Provisional; Region: PRK13404
335659013332	D-hydantoinases (D-HYD) also called dihydropyrimidases (DHPase) and related proteins; DHPases are a family of enzymes that catalyze the reversible hydrolytic ring opening of the amide bond in five- or six-membered cyclic diamides, like dihydropyrimidine...; Region: D-HYD; cd01314
335659013333	tetramer interface [polypeptide binding]; other site
335659013334	active site
335659013335	Asp/Glu/Hydantoin racemase; Region: Asp_Glu_race; cl00518
335659013336	ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116
335659013337	ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293
335659013338	Walker A/P-loop; other site
335659013339	ATP binding site [chemical binding]; other site
335659013340	Q-loop/lid; other site
335659013341	ABC transporter signature motif; other site
335659013342	Walker B; other site
335659013343	D-loop; other site
335659013344	H-loop/switch region; other site
335659013345	ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600
335659013346	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
335659013347	dimer interface [polypeptide binding]; other site
335659013348	conserved gate region; other site
335659013349	putative PBP binding loops; other site
335659013350	ABC-ATPase subunit interface; other site
335659013351	ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components [Inorganic ion transport and metabolism]; Region: TauA; COG0715
335659013352	NMT1-like family; Region: NMT1_2; pfam13379
335659013353	Transcriptional regulators [Transcription]; Region: GntR; COG1802
335659013354	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
335659013355	DNA-binding site [nucleotide binding]; DNA binding site
335659013356	FCD domain; Region: FCD; pfam07729
335659013357	Asp/Glu/Hydantoin racemase; Region: Asp_Glu_race; cl00518
335659013358	amidase; Provisional; Region: PRK07486
335659013359	Amidase; Region: Amidase; pfam01425
335659013360	ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842
335659013361	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
335659013362	Walker A/P-loop; other site
335659013363	ATP binding site [chemical binding]; other site
335659013364	Q-loop/lid; other site
335659013365	ABC transporter signature motif; other site
335659013366	Walker B; other site
335659013367	D-loop; other site
335659013368	H-loop/switch region; other site
335659013369	TOBE domain; Region: TOBE_2; pfam08402
335659013370	TOBE domain; Region: TOBE_2; pfam08402
335659013371	ABC-type Fe3+ transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: AfuA; COG1840
335659013372	Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416
335659013373	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
335659013374	dimer interface [polypeptide binding]; other site
335659013375	conserved gate region; other site
335659013376	putative PBP binding loops; other site
335659013377	ABC-ATPase subunit interface; other site
335659013378	ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177
335659013379	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
335659013380	dimer interface [polypeptide binding]; other site
335659013381	conserved gate region; other site
335659013382	putative PBP binding loops; other site
335659013383	ABC-ATPase subunit interface; other site
335659013384	HIUase (5-hydroxyisourate hydrolase) catalyzes the second step in a three-step ureide pathway in which 5-hydroxyisourate (HIU), a product of the uricase (urate oxidase) reaction, is hydrolyzed to 2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline (OHCU); Region: TLP_HIUase; cd05822
335659013385	active site
335659013386	homotetramer interface [polypeptide binding]; other site
335659013387	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
335659013388	putative substrate translocation pore; other site
335659013389	Major Facilitator Superfamily; Region: MFS_1; pfam07690
335659013390	Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154
335659013391	Amidase; Region: Amidase; cl11426
335659013392	PepSY-associated TM helix; Region: PepSY_TM_3; pfam13706
335659013393	PepSY-associated TM helix; Region: PepSY_TM_2; pfam13703
335659013394	TonB-dependent siderophore receptor; Region: TonB-siderophor; TIGR01783
335659013395	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
335659013396	N-terminal plug; other site
335659013397	ligand-binding site [chemical binding]; other site
335659013398	cobalamin riboswitch as predicted by Rfam v8.1 (RF00174), score 139.18
335659013399	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
335659013400	catalytic core [active]
335659013401	Phosphoribosyltransferase; Region: DBI_PRT; pfam02277
335659013402	Nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase (DMB-PRT), also called CobT; Region: DMB-PRT_CobT; cd02439
335659013403	putative dimer interface [polypeptide binding]; other site
335659013404	active site pocket [active]
335659013405	putative cataytic base [active]
335659013406	Precorrin-6A synthase, the cobalamin biosynthesis enzyme CobF; Region: Precorrin-6A-synthase; cd11643
335659013407	active site
335659013408	SAM binding site [chemical binding]; other site
335659013409	homodimer interface [polypeptide binding]; other site
335659013410	cobalamin riboswitch as predicted by Rfam v8.1 (RF00174), score 102.51
335659013411	Uroporphyrin-III C-methyltransferase (S-Adenosyl-L-methionine:uroporphyrinogen III methyltransferase, SUMT); Region: SUMT; cd11642
335659013412	active site
335659013413	SAM binding site [chemical binding]; other site
335659013414	homodimer interface [polypeptide binding]; other site
335659013415	cobyrinic acid a,c-diamide synthase; Validated; Region: PRK01077
335659013416	dithiobiotin synthetase; Reviewed; Region: bioD; PRK00090
335659013417	Type 1 glutamine amidotransferase (GATase1) domain found in Cobyrinic Acid a,c-Diamide Synthase; Region: GATase1_CobB; cd03130
335659013418	Precorrin-4 C11-methyltransferase (CbiF/CobM); Region: Precorrin-4_C11-MT; cd11641
335659013419	active site
335659013420	SAM binding site [chemical binding]; other site
335659013421	homodimer interface [polypeptide binding]; other site
335659013422	Cobalamin synthesis G C-terminus; Region: CbiG_C; pfam01890
335659013423	Precorrin-6Y methyltransferase, the cobalamin biosynthesis enzyme CbiE; Region: Precorrin-6Y-methylase; cd11644
335659013424	active site
335659013425	putative homodimer interface [polypeptide binding]; other site
335659013426	SAM binding site [chemical binding]; other site
335659013427	Precorrin-6B methylase 2 [Coenzyme metabolism]; Region: CobL; COG2242
335659013428	Methyltransferase domain; Region: Methyltransf_18; pfam12847
335659013429	Precorrin-6x reductase CbiJ/CobK; Region: CbiJ; pfam02571
335659013430	Precorrin-3B C(17)-methyltransferase (CobJ/CbiH); Region: Precorrin_3B_C17_MT; cd11646
335659013431	active site
335659013432	SAM binding site [chemical binding]; other site
335659013433	homodimer interface [polypeptide binding]; other site
335659013434	Precorrin-2 C20-methyltransferase, also named CobI or CbiL; Region: Precorrin_2_C20_MT; cd11645
335659013435	active site
335659013436	SAM binding site [chemical binding]; other site
335659013437	homodimer interface [polypeptide binding]; other site
335659013438	precorrin-8X methylmutase; Reviewed; Region: cobH; PRK08285
335659013439	Precorrin-8X methylmutase; Region: CbiC; pfam02570
335659013440	precorrin-3B synthase; Region: CobG; TIGR02435
335659013441	Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460
335659013442	cobaltochelatase subunit CobN; Reviewed; Region: cobN; PRK12321
335659013443	CobN subunit of cobaltochelatase, bchH and chlH subunits of magnesium chelatases, and similar proteins; Region: CobN_like; cd10150
335659013444	cobalamin biosynthesis protein CobW; Region: CobW; TIGR02475
335659013445	CobW/HypB/UreG, nucleotide-binding domain; Region: cobW; pfam02492
335659013446	Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; pfam07683
335659013447	Protein of unknown function (DUF1636); Region: DUF1636; pfam07845
335659013448	cobalamin riboswitch as predicted by Rfam v8.1 (RF00174), score 93.25
335659013449	ATP:corrinoid adenosyltransferase [Coenzyme metabolism]; Region: BtuR; COG2109
335659013450	ATP:corrinoid adenosyltransferase BtuR/CobO/CobP. This family consists of the BtuR, CobO, CobP proteins all of which are Cob(I)alamin (vitamin B12) adenosyltransferase, which is involved in cobalamin (vitamin B12) biosynthesis. This enzyme is a homodimer; Region: CobA_CobO_BtuR; cd00561
335659013451	homodimer interface [polypeptide binding]; other site
335659013452	Walker A motif; other site
335659013453	ATP binding site [chemical binding]; other site
335659013454	hydroxycobalamin binding site [chemical binding]; other site
335659013455	Walker B motif; other site
335659013456	cobyric acid synthase; Provisional; Region: PRK00784
335659013457	dithiobiotin synthetase; Reviewed; Region: bioD; PRK00090
335659013458	Type 1 glutamine amidotransferase (GATase1) domain found in Cobyric Acid Synthase (CobQ); Region: GATase1_CobQ; cd01750
335659013459	catalytic triad [active]
335659013460	Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321
335659013461	L-threonine-O-3-phosphate decarboxylase; Region: L_thr_O3P_dcar; TIGR01140
335659013462	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
335659013463	catalytic residue [active]
335659013464	CobD/Cbib protein; Region: CobD_Cbib; pfam03186
335659013465	Adenosylcobinamide kinase / adenosylcobinamide phosphate guanyltransferase (CobU). CobU is bifunctional cobalbumin biosynthesis enzymes which display adenosylcobinamide kinase and adenosylcobinamide phosphate guanyltransferase activity. This enzyme is a...; Region: CobU; cd00544
335659013466	homotrimer interface [polypeptide binding]; other site
335659013467	Walker A motif; other site
335659013468	GTP binding site [chemical binding]; other site
335659013469	Walker B motif; other site
335659013470	cobalamin synthase; Reviewed; Region: cobS; PRK00235
335659013471	Subfamily of the nitroreductase family that includes BluB protein in Rhodobacter capsulatus is involved in the conversion of cobinamide to cobalamin in Cobalamin (vitamin B12) biosynthesis. Nitroreductases typically reduce their substrates by using NAD(P)...; Region: BluB; cd02145
335659013472	putative FMN binding site [chemical binding]; other site
335659013473	Hemolysin activation/secretion protein [Intracellular trafficking and secretion]; Region: FhaC; COG2831
335659013474	POTRA domain, ShlB-type; Region: POTRA_2; pfam08479
335659013475	Haemolysin secretion/activation protein ShlB/FhaC/HecB; Region: ShlB; pfam03865
335659013476	Surface antigen; Region: Bac_surface_Ag; pfam01103
335659013477	haemagglutination activity domain; Region: Haemagg_act; cl05436
335659013478	Type I periplasmic ligand-binding domain of uncharacterized ABC-type transport systems that are predicted to be involved in the uptake of amino acids, peptides, or inorganic ions; Region: PBP1_ABC_uncharacterized_transporter; cd06325
335659013479	zinc binding site [ion binding]; other site
335659013480	putative ligand binding site [chemical binding]; other site
335659013481	Cache domain; Region: Cache_1; pfam02743
335659013482	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
335659013483	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
335659013484	dimerization interface [polypeptide binding]; other site
335659013485	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
335659013486	dimer interface [polypeptide binding]; other site
335659013487	phosphorylation site [posttranslational modification]
335659013488	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
335659013489	ATP binding site [chemical binding]; other site
335659013490	Mg2+ binding site [ion binding]; other site
335659013491	G-X-G motif; other site
335659013492	Response regulator receiver domain; Region: Response_reg; pfam00072
335659013493	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
335659013494	active site
335659013495	phosphorylation site [posttranslational modification]
335659013496	intermolecular recognition site; other site
335659013497	dimerization interface [polypeptide binding]; other site
335659013498	Hpt domain; Region: Hpt; pfam01627
335659013499	putative binding surface; other site
335659013500	active site
335659013501	Rare lipoprotein A (RlpA)-like double-psi beta-barrel; Region: DPBB_1; pfam03330
335659013502	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
335659013503	LysR family transcriptional regulator; Provisional; Region: PRK14997
335659013504	The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422
335659013505	putative effector binding pocket; other site
335659013506	dimerization interface [polypeptide binding]; other site
335659013507	N-terminal domain of Sphingobium chlorophenolicum 2,6-dichloro-p-hydroquinone 1,2-dioxygenase (PcpA), and similar proteins; Region: PcpA_N_like; cd08346
335659013508	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
335659013509	Zn binding site [ion binding]; other site
335659013510	C-terminal domain of Sphingobium chlorophenolicum 2,6-dichloro-p-hydroquinone 1,2-dioxygenase (PcpA), and similar proteins; Region: PcpA_C_like; cd08347
335659013511	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
335659013512	Zn binding site [ion binding]; other site
335659013513	Predicted esterase [General function prediction only]; Region: COG0400
335659013514	Predicted acyltransferases [Lipid metabolism]; Region: COG1835
335659013515	Cupin domain; Region: Cupin_2; pfam07883
335659013516	flagellin B; Provisional; Region: PRK13588
335659013517	Uncharacterized conserved protein [Function unknown]; Region: COG5361
335659013518	Protein of unknown function (DUF1254); Region: DUF1254; pfam06863
335659013519	Protein of unknown function (DUF1214); Region: DUF1214; pfam06742
335659013520	amidase; Provisional; Region: PRK06828
335659013521	Amidase; Region: Amidase; cl11426
335659013522	ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747
335659013523	The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_6; cd08494
335659013524	dipeptide transporter ATP-binding subunit; Provisional; Region: dppF; PRK11308
335659013525	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
335659013526	Walker A/P-loop; other site
335659013527	ATP binding site [chemical binding]; other site
335659013528	Q-loop/lid; other site
335659013529	ABC transporter signature motif; other site
335659013530	Walker B; other site
335659013531	D-loop; other site
335659013532	H-loop/switch region; other site
335659013533	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097
335659013534	ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444
335659013535	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
335659013536	Walker A/P-loop; other site
335659013537	ATP binding site [chemical binding]; other site
335659013538	Q-loop/lid; other site
335659013539	ABC transporter signature motif; other site
335659013540	Walker B; other site
335659013541	D-loop; other site
335659013542	H-loop/switch region; other site
335659013543	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; pfam08352
335659013544	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173
335659013545	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
335659013546	dimer interface [polypeptide binding]; other site
335659013547	conserved gate region; other site
335659013548	putative PBP binding loops; other site
335659013549	ABC-ATPase subunit interface; other site
335659013550	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601
335659013551	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
335659013552	dimer interface [polypeptide binding]; other site
335659013553	conserved gate region; other site
335659013554	putative PBP binding loops; other site
335659013555	ABC-ATPase subunit interface; other site
335659013556	Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154
335659013557	Amidase; Region: Amidase; pfam01425
335659013558	Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524
335659013559	Fructokinases (FRKs) mainly from bacteria and plants are enzymes with high specificity for fructose, as are all FRKs, but they catalyzes the conversion of fructose to fructose-6-phosphate, which is an entry point into glycolysis via conversion into...; Region: bac_FRK; cd01167
335659013560	putative substrate binding site [chemical binding]; other site
335659013561	putative ATP binding site [chemical binding]; other site
335659013562	Yersinia Pseudotuberculosis carbohydrate kinase-like subgroup; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_YpCarbK_like; cd07782
335659013563	FGGY-family pentulose kinase; Region: 5C_CHO_kinase; TIGR01315
335659013564	N- and C-terminal domain interface [polypeptide binding]; other site
335659013565	active site
335659013566	MgATP binding site [chemical binding]; other site
335659013567	catalytic site [active]
335659013568	metal binding site [ion binding]; metal-binding site
335659013569	carbohydrate binding site [chemical binding]; other site
335659013570	putative homodimer interface [polypeptide binding]; other site
335659013571	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
335659013572	3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653
335659013573	NAD(P) binding site [chemical binding]; other site
335659013574	active site
335659013575	ABC-type sugar transport systems, ATPase components [Carbohydrate transport and metabolism]; Region: MalK; COG3839
335659013576	The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301
335659013577	Walker A/P-loop; other site
335659013578	ATP binding site [chemical binding]; other site
335659013579	Q-loop/lid; other site
335659013580	ABC transporter signature motif; other site
335659013581	Walker B; other site
335659013582	D-loop; other site
335659013583	H-loop/switch region; other site
335659013584	TOBE domain; Region: TOBE_2; pfam08402
335659013585	ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395
335659013586	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
335659013587	dimer interface [polypeptide binding]; other site
335659013588	conserved gate region; other site
335659013589	putative PBP binding loops; other site
335659013590	ABC-ATPase subunit interface; other site
335659013591	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427
335659013592	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
335659013593	dimer interface [polypeptide binding]; other site
335659013594	conserved gate region; other site
335659013595	putative PBP binding loops; other site
335659013596	ABC-ATPase subunit interface; other site
335659013597	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653
335659013598	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547
335659013599	Transcriptional regulator, contains sigma factor-related N-terminal domain [Transcription]; Region: DeoR; COG2390
335659013600	MarR family; Region: MarR_2; cl17246
335659013601	Putative sugar-binding domain; Region: Sugar-bind; pfam04198
335659013602	Predicted phosphatase/phosphohexomutase [General function prediction only]; Region: COG0637
335659013603	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
335659013604	motif II; other site
335659013605	Nitric oxide reductase activation protein [Inorganic ion transport and metabolism]; Region: NorD; COG4548
335659013606	norD type: Denitrifying bacteria contain both membrane bound and periplasmic nitrate reductases. Denitrification plays a major role  in completing the nitrogen cycle by converting nitrate or nitrite to nitrogen gas. The pathway for microbial...; Region: vWA_norD_type; cd01454
335659013607	metal ion-dependent adhesion site (MIDAS); other site
335659013608	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
335659013609	MoxR-like ATPases [General function prediction only]; Region: COG0714
335659013610	Walker A motif; other site
335659013611	ATP binding site [chemical binding]; other site
335659013612	Walker B motif; other site
335659013613	CbbQ/NirQ/NorQ C-terminal; Region: CbbQ_C; pfam08406
335659013614	Heme-copper oxidase subunit I.  Heme-copper oxidases are transmembrane protein complexes in the respiratory chains of prokaryotes and mitochondria which catalyze the reduction of O2 and simultaneously pump protons across the membrane.  The superfamily is...; Region: Heme_Cu_Oxidase_I; cl00275
335659013615	Cytochrome C and Quinol oxidase polypeptide I; Region: COX1; pfam00115
335659013616	D-pathway; other site
335659013617	K-pathway; other site
335659013618	Binuclear center (active site) [active]
335659013619	Putative proton exit pathway; other site
335659013620	Cytochrome c; Region: Cytochrom_C; pfam00034
335659013621	NorE_like subfamily of heme-copper oxidase subunit III.  Heme-copper oxidases include cytochrome c and ubiquinol oxidases.  Alcaligenes faecalis norE is found in a gene cluster containing norCB. norCB encodes the cytochrome c and cytochrome b subunits of...; Region: NorE_like; cd02862
335659013622	Subunit I/III interface [polypeptide binding]; other site
335659013623	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
335659013624	Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579
335659013625	Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579
335659013626	TM-ABC transporter signature motif; other site
335659013627	ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129
335659013628	First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216
335659013629	Walker A/P-loop; other site
335659013630	ATP binding site [chemical binding]; other site
335659013631	Q-loop/lid; other site
335659013632	ABC transporter signature motif; other site
335659013633	Walker B; other site
335659013634	D-loop; other site
335659013635	H-loop/switch region; other site
335659013636	Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215
335659013637	ABC-type xylose transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: XylF; COG4213
335659013638	Periplasmic xylose-binding component of the ABC-type transport systems that belong to a family of pentose/hexose sugar-binding proteins of the type I periplasmic binding protein (PBP1) superfamily; Region: PBP1_ABC_xylose_binding; cd01538
335659013639	putative ligand binding site [chemical binding]; other site
335659013640	Gluconolactonase [Carbohydrate transport and metabolism]; Region: COG3386
335659013641	galactose mutarotase_like; Region: galactose_mutarotase_like; cd09019
335659013642	active site
335659013643	catalytic residues [active]
335659013644	Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673
335659013645	Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408
335659013646	Transcriptional regulators [Transcription]; Region: FadR; COG2186
335659013647	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
335659013648	DNA-binding site [nucleotide binding]; DNA binding site
335659013649	FCD domain; Region: FCD; pfam07729
335659013650	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
335659013651	Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579
335659013652	TM-ABC transporter signature motif; other site
335659013653	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
335659013654	Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579
335659013655	TM-ABC transporter signature motif; other site
335659013656	ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129
335659013657	First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216
335659013658	Walker A/P-loop; other site
335659013659	ATP binding site [chemical binding]; other site
335659013660	Q-loop/lid; other site
335659013661	ABC transporter signature motif; other site
335659013662	Walker B; other site
335659013663	D-loop; other site
335659013664	H-loop/switch region; other site
335659013665	Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215
335659013666	Periplasmic binding domain of ABC-type YtfQ-like transport systems; Region: PBP1_YtfQ_like; cd06309
335659013667	Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407
335659013668	putative ligand binding site [chemical binding]; other site
335659013669	Fumarylacetoacetate (FAA) hydrolase family protein [General function prediction only]; Region: COG3970
335659013670	Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557
335659013671	HEAT repeats; Region: HEAT_2; pfam13646
335659013672	HEAT repeats; Region: HEAT_2; pfam13646
335659013673	HEAT repeats; Region: HEAT_2; pfam13646
335659013674	Sister chromatid cohesion C-terminus; Region: Nipped-B_C; pfam12830
335659013675	HEAT repeats; Region: HEAT_2; pfam13646
335659013676	HEAT repeats; Region: HEAT_2; pfam13646
335659013677	The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655
335659013678	4Fe-4S dicluster domain; Region: Fer4_7; pfam12838
335659013679	putative oxidoreductase; Provisional; Region: PRK08275
335659013680	L-aspartate oxidase; Provisional; Region: PRK06175
335659013681	Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910
335659013682	Flavodoxin reductases (ferredoxin-NADPH reductases) family 1 [Energy production and conversion]; Region: Hmp; COG1018
335659013683	Ferredoxin-NADP+ (oxido)reductase is an FAD-containing enzyme that catalyzes the reversible electron transfer between NADP(H) and electron carrier proteins such as ferredoxin and flavodoxin. Isoforms of these flavoproteins (i.e. having a non-covalently...; Region: FNR1; cd06195
335659013684	FAD binding pocket [chemical binding]; other site
335659013685	FAD binding motif [chemical binding]; other site
335659013686	phosphate binding motif [ion binding]; other site
335659013687	beta-alpha-beta structure motif; other site
335659013688	NAD binding pocket [chemical binding]; other site
335659013689	Protein of unknown function (DUF971); Region: DUF971; pfam06155
335659013690	cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664
335659013691	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
335659013692	ligand binding site [chemical binding]; other site
335659013693	flexible hinge region; other site
335659013694	Crp-like helix-turn-helix domain; Region: HTH_Crp_2; pfam13545
335659013695	ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components [Inorganic ion transport and metabolism]; Region: TauA; COG0715
335659013696	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cl17432
335659013697	NosL; Region: NosL; cl01769
335659013698	ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600
335659013699	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
335659013700	dimer interface [polypeptide binding]; other site
335659013701	conserved gate region; other site
335659013702	putative PBP binding loops; other site
335659013703	ABC-ATPase subunit interface; other site
335659013704	ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116
335659013705	ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293
335659013706	Walker A/P-loop; other site
335659013707	ATP binding site [chemical binding]; other site
335659013708	Q-loop/lid; other site
335659013709	ABC transporter signature motif; other site
335659013710	Walker B; other site
335659013711	D-loop; other site
335659013712	H-loop/switch region; other site
335659013713	Predicted membrane protein [Function unknown]; Region: COG2855
335659013714	ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410
335659013715	ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224
335659013716	Walker A/P-loop; other site
335659013717	ATP binding site [chemical binding]; other site
335659013718	Q-loop/lid; other site
335659013719	ABC transporter signature motif; other site
335659013720	Walker B; other site
335659013721	D-loop; other site
335659013722	H-loop/switch region; other site
335659013723	ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411
335659013724	ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219
335659013725	Walker A/P-loop; other site
335659013726	ATP binding site [chemical binding]; other site
335659013727	Q-loop/lid; other site
335659013728	ABC transporter signature motif; other site
335659013729	Walker B; other site
335659013730	D-loop; other site
335659013731	H-loop/switch region; other site
335659013732	ABC-type branched-chain amino acid transport system, permease component [Amino acid transport and metabolism]; Region: LivM; COG4177
335659013733	Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581
335659013734	TM-ABC transporter signature motif; other site
335659013735	Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582
335659013736	TM-ABC transporter signature motif; other site
335659013737	Periplasmic binding protein; Region: Peripla_BP_6; pfam13458
335659013738	Periplasmic solute-binding domain of active transport proteins; Region: PBP1_Arsenic_SBP_like; cd06330
335659013739	putative ligand binding site [chemical binding]; other site
335659013740	acyl-CoA synthetase; Validated; Region: PRK06145
335659013741	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
335659013742	Bacterial Bile acid CoA ligases and similar proteins; Region: BACL_like; cd05929
335659013743	acyl-activating enzyme (AAE) consensus motif; other site
335659013744	acyl-activating enzyme (AAE) consensus motif; other site
335659013745	putative AMP binding site [chemical binding]; other site
335659013746	putative active site [active]
335659013747	putative CoA binding site [chemical binding]; other site
335659013748	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
335659013749	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
335659013750	Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072
335659013751	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
335659013752	DSBA-like thioredoxin domain; Region: DSBA; pfam01323
335659013753	Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388
335659013754	Orn/Lys/Arg decarboxylase, N-terminal domain; Region: OKR_DC_1_N; pfam03709
335659013755	ornithine decarboxylase; Provisional; Region: PRK13578
335659013756	Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321
335659013757	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
335659013758	catalytic residue [active]
335659013759	Orn/Lys/Arg decarboxylase, C-terminal domain; Region: OKR_DC_1_C; pfam03711
335659013760	Sortase and related acyltransferases [Cell envelope biogenesis, outer membrane]; Region: COG1247
335659013761	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
335659013762	Coenzyme A binding pocket [chemical binding]; other site
335659013763	ornithine cyclodeaminase; Validated; Region: PRK06141
335659013764	ornithine cyclodeaminase; Validated; Region: PRK06823; cl17400
335659013765	flagellar basal body rod protein FlgC; Reviewed; Region: flgC; PRK05681
335659013766	Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; cl15855
335659013767	Phosphoglycerate dehydrogenase and related dehydrogenases [Amino acid transport and metabolism]; Region: SerA; COG0111
335659013768	Phosphoglycerate dehydrogenases, NAD-binding and catalytic domains; Region: PGDH_4; cd12173
335659013769	ligand binding site [chemical binding]; other site
335659013770	NAD binding site [chemical binding]; other site
335659013771	dimerization interface [polypeptide binding]; other site
335659013772	catalytic site [active]
335659013773	Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035
335659013774	PYR/PP interface [polypeptide binding]; other site
335659013775	dimer interface [polypeptide binding]; other site
335659013776	TPP binding site [chemical binding]; other site
335659013777	hypothetical protein; Provisional; Region: PRK06163
335659013778	Thiamine pyrophosphate (TPP) family, ComE subfamily, TPP-binding module; composed of proteins similar to Methanococcus jannaschii sulfopyruvate decarboxylase beta subunit (ComE). M. jannaschii sulfopyruvate decarboxylase (ComDE) is a dodecamer of six...; Region: TPP_ComE; cd03372
335659013779	TPP-binding site; other site
335659013780	Protein of unknown function (DUF1236); Region: DUF1236; pfam06823
335659013781	tartronate semialdehyde reductase; Provisional; Region: PRK15059
335659013782	6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599
335659013783	Hydroxypyruvate isomerase [Carbohydrate transport and metabolism]; Region: Hfi; COG3622
335659013784	glyoxylate carboligase; Provisional; Region: PRK11269
335659013785	Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035
335659013786	PYR/PP interface [polypeptide binding]; other site
335659013787	dimer interface [polypeptide binding]; other site
335659013788	TPP binding site [chemical binding]; other site
335659013789	Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205
335659013790	Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cl01629
335659013791	TPP-binding site [chemical binding]; other site
335659013792	Adenine deaminase [Nucleotide transport and metabolism]; Region: AdeC; COG1001
335659013793	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
335659013794	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
335659013795	active site
335659013796	Adenine deaminase C-terminal domain; Region: Adenine_deam_C; pfam13382
335659013797	Uncharacterized conserved protein [Function unknown]; Region: COG1432
335659013798	Uncharacterized subfamily of N-terminal LabA-like domains; Region: LabA_like_N_1; cd11297
335659013799	putative metal binding site [ion binding]; other site
335659013800	C-terminal domain of LabA_like proteins; Region: LabA_like_C; cd10146
335659013801	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3333
335659013802	Tripartite tricarboxylate transporter TctB family; Region: TctB; pfam07331
335659013803	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3181
335659013804	helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346
335659013805	Transcriptional regulator [Transcription]; Region: IclR; COG1414
335659013806	Bacterial transcriptional regulator; Region: IclR; pfam01614
335659013807	ATP-grasp domain; Region: ATP-grasp_5; pfam13549
335659013808	Acyl-CoA synthetase (NDP forming) [Energy production and conversion]; Region: COG1042
335659013809	acetyl coenzyme A synthetase (ADP forming), alpha domain; Region: AcCoA-syn-alpha; TIGR02717
335659013810	CoA binding domain; Region: CoA_binding_2; pfam13380
335659013811	Succinyl-CoA ligase like flavodoxin domain; Region: Succ_CoA_lig; pfam13607
335659013812	Transcriptional regulators [Transcription]; Region: GntR; COG1802
335659013813	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
335659013814	DNA-binding site [nucleotide binding]; DNA binding site
335659013815	FCD domain; Region: FCD; pfam07729
335659013816	putative oxalyl-CoA decarboxylase; Validated; Region: PRK09259
335659013817	Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035
335659013818	PYR/PP interface [polypeptide binding]; other site
335659013819	dimer interface [polypeptide binding]; other site
335659013820	TPP binding site [chemical binding]; other site
335659013821	Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205
335659013822	Thiamine pyrophosphate (TPP) family, BZL_OCoD_HPCL subfamily, TPP-binding module; composed of proteins similar to benzaldehyde lyase (BZL), oxalyl-CoA decarboxylase (OCoD) and 2-hydroxyphytanoyl-CoA lyase (2-HPCL). Pseudomonas fluorescens biovar I BZL...; Region: TPP_BZL_OCoD_HPCL; cd02004
335659013823	TPP-binding site; other site
335659013824	dimer interface [polypeptide binding]; other site
335659013825	formyl-coenzyme A transferase; Provisional; Region: PRK05398
335659013826	CoA-transferase family III; Region: CoA_transf_3; pfam02515
335659013827	Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea.  CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458
335659013828	DNA-binding site [nucleotide binding]; DNA binding site
335659013829	RNA-binding motif; other site
335659013830	Putative hydrophobic ligand-binding SRPBCC domain of an uncharacterized subgroup of CalC- and Aha1-like proteins; Region: SRPBCC_CalC_Aha1-like_2; cd08895
335659013831	putative hydrophobic ligand binding site [chemical binding]; other site
335659013832	Escherichia coli YegD, a putative chaperone protein, and related proteins; Region: YegD_like; cd10231
335659013833	putative chaperone; Provisional; Region: PRK11678
335659013834	nucleotide binding site [chemical binding]; other site
335659013835	putative NEF/HSP70 interaction site [polypeptide binding]; other site
335659013836	SBD interface [polypeptide binding]; other site
335659013837	oxalate/formate antiporter; Region: oxa_formateAnti; TIGR04259
335659013838	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
335659013839	putative substrate translocation pore; other site
335659013840	oxalate/formate antiporter; Region: oxa_formateAnti; TIGR04259
335659013841	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
335659013842	putative substrate translocation pore; other site
335659013843	FOG: CBS domain [General function prediction only]; Region: COG0517
335659013844	The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354
335659013845	2-dehydropantoate 2-reductase; Reviewed; Region: PRK06522
335659013846	Ketopantoate reductase PanE/ApbA; Region: ApbA; pfam02558
335659013847	Ketopantoate reductase PanE/ApbA C terminal; Region: ApbA_C; pfam08546
335659013848	Domain of unknown function (DUF2437); Region: DUF2437; pfam10370
335659013849	2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179
335659013850	Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557
335659013851	chromosome segregation protein SMC, primarily archaeal type; Region: SMC_prok_A; TIGR02169
335659013852	Dioxygenases related to 2-nitropropane dioxygenase [General function prediction only]; Region: COG2070
335659013853	2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730
335659013854	FMN binding site [chemical binding]; other site
335659013855	substrate binding site [chemical binding]; other site
335659013856	putative catalytic residue [active]
335659013857	NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604
335659013858	Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912
335659013859	NAD(P) binding site [chemical binding]; other site
335659013860	Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053
335659013861	Cation efflux family; Region: Cation_efflux; cl00316
335659013862	Cation efflux family; Region: Cation_efflux; cl00316
335659013863	Cation efflux family; Region: Cation_efflux; cl00316
335659013864	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
335659013865	PAS fold; Region: PAS_3; pfam08447
335659013866	putative active site [active]
335659013867	heme pocket [chemical binding]; other site
335659013868	phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966
335659013869	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
335659013870	dimer interface [polypeptide binding]; other site
335659013871	phosphorylation site [posttranslational modification]
335659013872	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
335659013873	ATP binding site [chemical binding]; other site
335659013874	Mg2+ binding site [ion binding]; other site
335659013875	G-X-G motif; other site
335659013876	Transcriptional regulator [Transcription]; Region: LysR; COG0583
335659013877	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
335659013878	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466
335659013879	dimerization interface [polypeptide binding]; other site
335659013880	formate dehydrogenase subunit gamma; Validated; Region: PRK05988
335659013881	Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388
335659013882	TRX-like [2Fe-2S] Ferredoxin (Fd) family, NAD-dependent formate dehydrogenase (FDH) beta subunit; composed of proteins similar to the beta subunit of NAD-linked FDH of Ralstonia eutropha, a soluble enzyme that catalyzes the irreversible oxidation of...; Region: TRX_Fd_FDH_beta; cd03063
335659013883	putative dimer interface [polypeptide binding]; other site
335659013884	NADH:ubiquinone oxidoreductase, NADH-binding (51 kD) subunit [Energy production and conversion]; Region: NuoF; COG1894
335659013885	NADH-ubiquinone oxidoreductase-F iron-sulfur binding region; Region: NADH_4Fe-4S; smart00928
335659013886	Uncharacterized anaerobic dehydrogenase [General function prediction only]; Region: COG3383
335659013887	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
335659013888	catalytic loop [active]
335659013889	iron binding site [ion binding]; other site
335659013890	NADH-ubiquinone oxidoreductase-G iron-sulfur binding region; Region: NADH-G_4Fe-4S_3; pfam10588
335659013891	Formate dehydrogenase H (Formate-Dh-H) catalyzes the reversible oxidation of formate to CO2 with the release of a proton and two electrons. It is a component of the anaerobic formate hydrogen lyase complex. The E. coli formate dehydrogenase H (Fdh-H) is...; Region: MopB_Formate-Dh-H; cd02753
335659013892	[4Fe-4S] binding site [ion binding]; other site
335659013893	molybdopterin cofactor binding site; other site
335659013894	This CD includes formate dehydrogenases (Fdh) H and N; nitrate reductases, Nap and Nas; and other related proteins. Formate dehydrogenase H is a component of the anaerobic formate hydrogen lyase complex  and catalyzes the reversible oxidation of formate...; Region: MopB_CT_Fdh-Nap-like; cd00508
335659013895	molybdopterin cofactor binding site; other site
335659013896	formate dehydrogenase accessory protein; Reviewed; Region: PRK00724
335659013897	NADH-dependant formate dehydrogenase delta subunit FdsD; Region: FdsD; pfam11390
335659013898	bifunctional glutamine-synthetase adenylyltransferase/deadenyltransferase; Provisional; Region: PRK14108
335659013899	Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401
335659013900	metal binding triad; other site
335659013901	GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335
335659013902	Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401
335659013903	metal binding triad; other site
335659013904	GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335
335659013905	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
335659013906	dimerization interface [polypeptide binding]; other site
335659013907	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
335659013908	dimer interface [polypeptide binding]; other site
335659013909	phosphorylation site [posttranslational modification]
335659013910	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
335659013911	ATP binding site [chemical binding]; other site
335659013912	Mg2+ binding site [ion binding]; other site
335659013913	G-X-G motif; other site
335659013914	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
335659013915	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
335659013916	active site
335659013917	phosphorylation site [posttranslational modification]
335659013918	intermolecular recognition site; other site
335659013919	dimerization interface [polypeptide binding]; other site
335659013920	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
335659013921	DNA binding site [nucleotide binding]
335659013922	periplasmic serine protease, Do/DeqQ family; Region: degP_htrA_DO; TIGR02037
335659013923	Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365
335659013924	PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987
335659013925	protein binding site [polypeptide binding]; other site
335659013926	PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987
335659013927	protein binding site [polypeptide binding]; other site
335659013928	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054
335659013929	dimerization interface [polypeptide binding]; other site
335659013930	Methyl-accepting chemotaxis protein (MCP) signalling domain; Region: MCPsignal; pfam00015
335659013931	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
335659013932	dimer interface [polypeptide binding]; other site
335659013933	putative CheW interface [polypeptide binding]; other site
335659013934	Cytochrome C biogenesis protein; Region: CcmH; pfam03918
335659013935	Cytochrome c biogenesis factor [Posttranslational modification, protein turnover, chaperones]; Region: CcmF; COG1138
335659013936	cytochrome c-type biogenesis protein CcmE; Reviewed; Region: PRK13254
335659013937	Cytochrome c biogenesis factor [Posttranslational modification, protein turnover, chaperones]; Region: COG4235
335659013938	cytochrome c-type biogenesis protein CcmI; Region: cytochro_ccmI; TIGR03142
335659013939	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429
335659013940	binding surface
335659013941	TPR motif; other site
335659013942	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
335659013943	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054
335659013944	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
335659013945	ATP binding site [chemical binding]; other site
335659013946	Mg2+ binding site [ion binding]; other site
335659013947	G-X-G motif; other site
335659013948	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
335659013949	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
335659013950	active site
335659013951	phosphorylation site [posttranslational modification]
335659013952	intermolecular recognition site; other site
335659013953	dimerization interface [polypeptide binding]; other site
335659013954	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
335659013955	DNA binding site [nucleotide binding]
335659013956	Ku-homolog [Replication, recombination, and repair]; Region: COG1273
335659013957	Ku-core domain, Ku-like subfamily; composed of prokaryotic homologs of the eukaryotic DNA binding protein Ku. The alignment includes the core domain shared by the prokaryotic YkoV-like proteins and the eukaryotic Ku70 and Ku80. The prokaryotic Ku...; Region: KU_like; cd00789
335659013958	putative DNA binding site [nucleotide binding]; other site
335659013959	putative homodimer interface [polypeptide binding]; other site
335659013960	Flp/Fap pilin component; Region: Flp_Fap; pfam04964
335659013961	thymidine phosphorylase; Provisional; Region: PRK04350
335659013962	Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885
335659013963	Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591
335659013964	Pyrimidine nucleoside phosphorylase C-terminal domain; Region: PYNP_C; smart00941
335659013965	phosphoribosylpyrophosphate synthetase; Provisional; Region: PRK07199
335659013966	N-terminal domain of ribose phosphate pyrophosphokinase; Region: Pribosyltran_N; pfam13793
335659013967	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
335659013968	active site
335659013969	Predicted exonuclease of the beta-lactamase fold involved in RNA processing [Translation, ribosomal structure and biogenesis]; Region: YSH1; COG1236
335659013970	Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849
335659013971	Beta-Casp domain; Region: Beta-Casp; smart01027
335659013972	RNA-metabolising metallo-beta-lactamase; Region: RMMBL; pfam07521
335659013973	PRC-barrel domain; Region: PRC; pfam05239
335659013974	DNA polymerase III subunits gamma and tau; Provisional; Region: PRK14951
335659013975	hypothetical protein; Provisional; Region: PRK06154
335659013976	Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035
335659013977	PYR/PP interface [polypeptide binding]; other site
335659013978	dimer interface [polypeptide binding]; other site
335659013979	TPP binding site [chemical binding]; other site
335659013980	Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205
335659013981	Thiamine pyrophosphate (TPP) family, BZL_OCoD_HPCL subfamily, TPP-binding module; composed of proteins similar to benzaldehyde lyase (BZL), oxalyl-CoA decarboxylase (OCoD) and 2-hydroxyphytanoyl-CoA lyase (2-HPCL). Pseudomonas fluorescens biovar I BZL...; Region: TPP_BZL_OCoD_HPCL; cd02004
335659013982	TPP-binding site; other site
335659013983	dimer interface [polypeptide binding]; other site
335659013984	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
335659013985	Major Facilitator Superfamily; Region: MFS_1; pfam07690
335659013986	putative substrate translocation pore; other site
335659013987	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
335659013988	hypothetical protein; Provisional; Region: PRK05170
335659013989	Transglycosylase; Region: Transgly; pfam00912
335659013990	penicillin-binding protein, 1A family; Region: PBP_1a_fam; TIGR02074
335659013991	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760
335659013992	Protein of unknown function (DUF1214); Region: DUF1214; cl08447
335659013993	Predicted integral membrane protein [Function unknown]; Region: COG5436
335659013994	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
335659013995	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
335659013996	Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596
335659013997	Putative lysophospholipase; Region: Hydrolase_4; pfam12146
335659013998	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244
335659013999	TonB-dependent copper receptor; Region: TonB-copper; TIGR01778
335659014000	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]; Region: DegQ; COG0265
335659014001	Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365
335659014002	PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987
335659014003	protein binding site [polypeptide binding]; other site
335659014004	Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071
335659014005	Group of bacterial proteins containing an alpha crystallin domain (ACD) similar to Lactobacillus plantarum (Lp) small heat shock proteins (sHsp) HSP 18.5, HSP 18.55 and HSP 19.3. sHsps are molecular chaperones that suppress protein aggregation and...; Region: ACD_LpsHSP_like; cd06471
335659014006	putative dimer interface [polypeptide binding]; other site
335659014007	chaperonin GroEL; Reviewed; Region: groEL; PRK12849
335659014008	GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344
335659014009	ring oligomerisation interface [polypeptide binding]; other site
335659014010	ATP/Mg binding site [chemical binding]; other site
335659014011	stacking interactions; other site
335659014012	hinge regions; other site
335659014013	Chaperonin 10 Kd subunit (cpn10 or GroES); Cpn10 cooperates with chaperonin 60 (cpn60 or GroEL), an ATPase, to assist the folding and assembly of proteins and is found in eubacterial cytosol, as well as in the matrix of mitochondria and chloroplasts. It...; Region: cpn10; cd00320
335659014014	oligomerisation interface [polypeptide binding]; other site
335659014015	mobile loop; other site
335659014016	roof hairpin; other site
335659014017	Major Facilitator Superfamily; Region: MFS_1; pfam07690
335659014018	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
335659014019	Major Facilitator Superfamily; Region: MFS_1; pfam07690
335659014020	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
335659014021	putative substrate translocation pore; other site
335659014022	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738
335659014023	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
335659014024	dimerization interface [polypeptide binding]; other site
335659014025	putative DNA binding site [nucleotide binding]; other site
335659014026	putative Zn2+ binding site [ion binding]; other site
335659014027	helix_turn_helix, Arsenical Resistance Operon Repressor; Region: HTH_ARSR; smart00418
335659014028	putative DNA binding site [nucleotide binding]; other site
335659014029	Low molecular weight phosphatase family; Region: LMWPc; cl00105
335659014030	Protein-tyrosine-phosphatase [Signal transduction mechanisms]; Region: Wzb; COG0394
335659014031	active site
335659014032	Arsenite efflux pump ACR3 and related permeases [Inorganic ion transport and metabolism]; Region: ACR3; COG0798
335659014033	Sodium Bile acid symporter family; Region: SBF; cl17470
335659014034	Arsenate Reductase (ArsC) family, ArsC subfamily; arsenic reductases similar to that encoded by arsC on the R733 plasmid of Escherichia coli. E. coli ArsC catalyzes the reduction of arsenate [As(V)] to arsenite [As(III)], the first step in the...; Region: ArsC_ArsC; cd03034
335659014035	ArsC family; Region: ArsC; pfam03960
335659014036	catalytic residues [active]
335659014037	Uncharacterized conserved protein [Function unknown]; Region: COG3791
335659014038	ferrichrome receptor precursor protein; Provisional; Region: PRK14050
335659014039	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
335659014040	N-terminal plug; other site
335659014041	ligand-binding site [chemical binding]; other site
335659014042	Protein of unknown function (DUF1491); Region: DUF1491; pfam07372
335659014043	Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471
335659014044	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
335659014045	phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966
335659014046	putative active site [active]
335659014047	heme pocket [chemical binding]; other site
335659014048	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
335659014049	dimer interface [polypeptide binding]; other site
335659014050	phosphorylation site [posttranslational modification]
335659014051	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
335659014052	ATP binding site [chemical binding]; other site
335659014053	Mg2+ binding site [ion binding]; other site
335659014054	G-X-G motif; other site
335659014055	Cysteine desulfurase SufE subunit [Posttranslational modification, protein turnover, chaperones]; Region: sufE; COG2166
335659014056	Predicted transcriptional regulator [Transcription]; Region: COG4957
335659014057	aldolase II superfamily protein; Provisional; Region: PRK07044
335659014058	intersubunit interface [polypeptide binding]; other site
335659014059	active site
335659014060	Zn2+ binding site [ion binding]; other site
335659014061	hypothetical protein; Validated; Region: PRK09104
335659014062	Uncharacterized M20 Dipeptidases; Region: M20_dipept_like_3; cd05680
335659014063	metal binding site [ion binding]; metal-binding site
335659014064	putative dimer interface [polypeptide binding]; other site
335659014065	Protein of unknown function (DUF2029); Region: DUF2029; pfam09594
335659014066	Bacterial protein of unknown function (DUF853); Region: DUF853; pfam05872
335659014067	Domain of unknown function (DUF4332); Region: DUF4332; pfam14229
335659014068	DHPS subgroup of Pterin binding enzymes. DHPS (dihydropteroate synthase), a functional homodimer, catalyzes the condensation of p-aminobenzoic acid (pABA) in the de novo biosynthesis of folate, which is an essential cofactor in both nucleic acid and...; Region: DHPS; cd00739
335659014069	dihydropteroate synthase; Region: DHPS; TIGR01496
335659014070	substrate binding pocket [chemical binding]; other site
335659014071	dimer interface [polypeptide binding]; other site
335659014072	inhibitor binding site; inhibition site
335659014073	Dihydroneopterin aldolase (DHNA) and 7,8-dihydroneopterin triphosphate epimerase domain (DHNTPE); these enzymes have been designated folB and folX, respectively. Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and...; Region: DHNA_DHNTPE; cd00534
335659014074	homooctamer interface [polypeptide binding]; other site
335659014075	active site
335659014076	7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase (HPPK). Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and amino acids as well as formyl-tRNA. Mammalian cells are able to utilize pre-formed folates after...; Region: HPPK; cd00483
335659014077	catalytic center binding site [active]
335659014078	ATP binding site [chemical binding]; other site
335659014079	methylmalonyl-CoA mutase, heterodimeric type, beta chain; Region: mmCoA_mut_beta; TIGR00642
335659014080	Coenzyme B12-dependent-methylmalonyl coenzyme A (CoA) mutase (MCM) family, Beta subunit-like subfamily; contains bacterial proteins similar to the beta subunit of MCMs from Propionbacterium shermanni and Streptomyces cinnamonensis, which are alpha/beta...; Region: MM_CoA_mutase_beta; cd03677
335659014081	heterodimer interface [polypeptide binding]; other site
335659014082	substrate interaction site [chemical binding]; other site
335659014083	B12 binding domain (B12-BD). Most of the members bind different cobalamid derivates, like B12 (adenosylcobamide) or methylcobalamin or methyl-Co(III) 5-hydroxybenzimidazolylcobamide. This domain is found in several enzymes, such as glutamate mutase; Region: B12-binding_like; cl00293
335659014084	Uncharacterized conserved protein [Function unknown]; Region: COG3791
335659014085	methylmalonyl-CoA mutase; Reviewed; Region: PRK09426
335659014086	Coenzyme B12-dependent-methylmalonyl coenzyme A (CoA) mutase (MCM) family, Alpha subunit-like subfamily; contains proteins similar to the alpha subunit of Propionbacterium shermanni MCM, as well as human and E. coli MCM. Members of this subfamily contain...; Region: MM_CoA_mutase_alpha_like; cd03679
335659014087	active site
335659014088	substrate binding site [chemical binding]; other site
335659014089	coenzyme B12 binding site [chemical binding]; other site
335659014090	methylmalonyl CoA mutase B12 binding domain. This domain binds to B12 (adenosylcobamide), which initiates the conversion of succinyl CoA and methylmalonyl CoA by forming an adenosyl radical, which then undergoes a rearrangement exchanging a hydrogen atom...; Region: MM_CoA_mut_B12_BD; cd02071
335659014091	B12 binding site [chemical binding]; other site
335659014092	cobalt ligand [ion binding]; other site
335659014093	Protein of unknown function (DUF3298); Region: DUF3298; pfam11738
335659014094	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3181
335659014095	Tripartite tricarboxylate transporter TctA family; Region: TctA; pfam01970
335659014096	membrane ATPase/protein kinase; Provisional; Region: PRK09435
335659014097	The function of this protein family is unkown. The protein sequences are similar to the ArgK protein in E. coli. ArgK protein is a membrane ATPase which is required for transporting arginine, ornithine and lysine into the cells by the arginine and...; Region: ArgK-like; cd03114
335659014098	Walker A; other site
335659014099	Pyroglutamyl peptidase (PGP) type I, also known as pyrrolidone carboxyl peptidase (pcp) type I:  Enzymes responsible for cleaving pyroglutamate (pGlu) from the N-terminal end of specialized proteins. The N-terminal pGlu protects these proteins from...; Region: Peptidase_C15; cd00501
335659014100	putative substrate binding pocket [chemical binding]; other site
335659014101	AC domain interface; other site
335659014102	catalytic triad [active]
335659014103	AB domain interface; other site
335659014104	interchain disulfide; other site
335659014105	twin-arg-translocated uncharacterized repeat protein; Region: RR_plus_rpt_1; TIGR03808
335659014106	putative cofactor-binding repeat; Region: RR_fam_repeat; TIGR03807
335659014107	TIGR03809 family protein; Region: TIGR03809
335659014108	Peptidase S8 family domain, uncharacterized subfamily 4; Region: Peptidases_S8_4; cd05561
335659014109	active site
335659014110	catalytic triad [active]
335659014111	RNA polymerase sigma factor; Provisional; Region: PRK12515
335659014112	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
335659014113	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
335659014114	DNA binding residues [nucleotide binding]
335659014115	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
335659014116	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
335659014117	metal binding site [ion binding]; metal-binding site
335659014118	active site
335659014119	I-site; other site
335659014120	Uncharacterized protein conserved in bacteria (DUF2336); Region: DUF2336; pfam10098
335659014121	Aerobic-type carbon monoxide dehydrogenase, large subunit CoxL/CutL homologs [Energy production and conversion]; Region: CoxL; COG1529
335659014122	Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; smart01008
335659014123	Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738
335659014124	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM/CutM homologs [Energy production and conversion]; Region: CoxM; COG1319
335659014125	CO dehydrogenase flavoprotein C-terminal domain; Region: CO_deh_flav_C; smart01092
335659014126	Aerobic-type carbon monoxide dehydrogenase, small subunit CoxS/CutS homologs [Energy production and conversion]; Region: CoxS; COG2080
335659014127	[2Fe-2S] binding domain; Region: Fer2_2; pfam01799
335659014128	Protein of unknown function (DUF1109); Region: DUF1109; pfam06532
335659014129	RNA polymerase sigma factor; Provisional; Region: PRK12512
335659014130	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
335659014131	Sigma-70, region 4; Region: Sigma70_r4_2; pfam08281
335659014132	DNA binding residues [nucleotide binding]
335659014133	enoyl-CoA hydratase; Provisional; Region: PRK05862
335659014134	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
335659014135	substrate binding site [chemical binding]; other site
335659014136	oxyanion hole (OAH) forming residues; other site
335659014137	trimer interface [polypeptide binding]; other site
335659014138	type I secretion outer membrane protein, TolC family; Region: type_I_sec_TolC; TIGR01844
335659014139	Predicted metal-dependent hydrolase of the TIM-barrel fold [General function prediction only]; Region: COG3618
335659014140	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
335659014141	active site
335659014142	LysE type translocator; Region: LysE; cl00565
335659014143	Putative silver efflux pump [Inorganic ion transport and metabolism]; Region: COG3696
335659014144	Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404
335659014145	Membrane Fusion Protein cluster 2 (function with RND porters); Region: 8a0102; TIGR00999
335659014146	HlyD family secretion protein; Region: HlyD_3; pfam13437
335659014147	Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804
335659014148	CoA-transferase family III; Region: CoA_transf_3; pfam02515
335659014149	3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653
335659014150	classical (c) SDRs; Region: SDR_c; cd05233
335659014151	NAD(P) binding site [chemical binding]; other site
335659014152	active site
335659014153	error-prone DNA polymerase; Validated; Region: dnaE2; PRK05672
335659014154	Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III at DnaE2 gene; Region: PHP_PolIIIA_DnaE2; cd07434
335659014155	putative active site [active]
335659014156	putative PHP Thumb interface [polypeptide binding]; other site
335659014157	DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485
335659014158	generic binding surface I; other site
335659014159	generic binding surface II; other site
335659014160	DNA Polymerase Y-family; Region: PolY_like; cd03468
335659014161	active site
335659014162	DNA binding site [nucleotide binding]
335659014163	Uncharacterized conserved protein [Function unknown]; Region: COG4544
335659014164	putative DNA modification/repair radical SAM protein; Region: rSAM_link_UDG; TIGR03916
335659014165	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
335659014166	FeS/SAM binding site; other site
335659014167	probable DNA metabolism protein; Region: SAM_7_link_chp; TIGR03915
335659014168	Family 4 Uracil-DNA glycosylase (UDG), found exclusively in thermophilic organisms; Region: UDG_F4_TTUDGA_like; cd10030
335659014169	Fe-S cluster binding site [ion binding]; other site
335659014170	active site
335659014171	Phosphate/sulphate permeases [Inorganic ion transport and metabolism]; Region: PitA; COG0306
335659014172	Phosphate/sulphate permeases [Inorganic ion transport and metabolism]; Region: PitA; COG0306
335659014173	Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473
335659014174	M20 Peptidase Aminoacylase 1 subfamily; Region: M20_Acy1_like1; cd05666
335659014175	metal binding site [ion binding]; metal-binding site
335659014176	putative dimer interface [polypeptide binding]; other site
335659014177	choline dehydrogenase; Validated; Region: PRK02106
335659014178	lycopene cyclase; Region: lycopene_cycl; TIGR01789
335659014179	GMC oxidoreductase; Region: GMC_oxred_C; pfam05199
335659014180	Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596
335659014181	Putative lysophospholipase; Region: Hydrolase_4; pfam12146
335659014182	metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995
335659014183	Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149
335659014184	active site
335659014185	metal binding site [ion binding]; metal-binding site
335659014186	Cupredoxin-like domain; Region: Cupredoxin_1; cl17234
335659014187	Plastocyanin [Energy production and conversion]; Region: PetE; COG3794
335659014188	RNA polymerase sigma factor; Provisional; Region: PRK11924
335659014189	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
335659014190	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
335659014191	DNA binding residues [nucleotide binding]
335659014192	Predicted transmembrane transcriptional regulator (anti-sigma factor) [Transcription]; Region: COG5662
335659014193	Putative zinc-finger; Region: zf-HC2; pfam13490
335659014194	Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610
335659014195	Ornithine/acetylornithine aminotransferase [Amino acid transport and metabolism]; Region: ArgD; COG4992
335659014196	inhibitor-cofactor binding pocket; inhibition site
335659014197	pyridoxal 5'-phosphate binding site [chemical binding]; other site
335659014198	catalytic residue [active]
335659014199	Uncharacterized protein conserved in bacteria (DUF2147); Region: DUF2147; pfam09917
335659014200	hopanoid biosynthesis associated RND transporter like protein HpnN; Region: HpnN; TIGR03480
335659014201	beta-carotene 15,15'-monooxygenase, Brp/Blh family; Region: blh_monoox; TIGR03753
335659014202	4-hydroxy-3-methylbut-2-enyl diphosphate reductase; Reviewed; Region: ispH; PRK01045
335659014203	4-Hydroxy-3-methylbut-2-enyl diphosphate reductase IspH [Lipid metabolism]; Region: lytB; COG0761
335659014204	hopanoid biosynthesis associated radical SAM protein HpnH; Region: HpnH; TIGR03470
335659014205	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
335659014206	FeS/SAM binding site; other site
335659014207	Domain of unknown function (DUF3463); Region: DUF3463; pfam11946
335659014208	Opacity protein and related surface antigens [Cell envelope biogenesis, outer membrane]; Region: COG3637
335659014209	hypothetical protein; Provisional; Region: PRK07077
335659014210	squalene-hopene cyclase; Region: hopene_cyclase; TIGR01507
335659014211	Squalene cyclase (SQCY) domain subgroup 1; found in class II terpene cyclases that have an alpha 6 - alpha 6 barrel fold. Squalene cyclase (SQCY)  and 2,3-oxidosqualene cyclase (OSQCY) are integral membrane proteins that catalyze a cationic cyclization...; Region: SQCY_1; cd02892
335659014212	Active site cavity [active]
335659014213	catalytic acid [active]
335659014214	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
335659014215	squalene-associated FAD-dependent desaturase; Region: HpnE; TIGR03467
335659014216	Trans-Isoprenyl Diphosphate Synthases, head-to-head; Region: Trans_IPPS_HH; cd00683
335659014217	active site lid residues [active]
335659014218	substrate binding pocket [chemical binding]; other site
335659014219	catalytic residues [active]
335659014220	substrate-Mg2+ binding site; other site
335659014221	aspartate-rich region 1; other site
335659014222	aspartate-rich region 2; other site
335659014223	Trans-Isoprenyl Diphosphate Synthases, head-to-head; Region: Trans_IPPS_HH; cd00683
335659014224	active site lid residues [active]
335659014225	substrate binding pocket [chemical binding]; other site
335659014226	catalytic residues [active]
335659014227	substrate-Mg2+ binding site; other site
335659014228	aspartate-rich region 1; other site
335659014229	aspartate-rich region 2; other site
335659014230	Predicted exporters of the RND superfamily [General function prediction only]; Region: COG1033
335659014231	ethanolamine ammonia-lyase small subunit; Provisional; Region: PRK05465
335659014232	B12 binding domain (B12-BD). Most of the members bind different cobalamid derivates, like B12 (adenosylcobamide) or methylcobalamin or methyl-Co(III) 5-hydroxybenzimidazolylcobamide. This domain is found in several enzymes, such as glutamate mutase; Region: B12-binding_like; cl00293
335659014233	B12 binding site [chemical binding]; other site
335659014234	Elongator protein 3, MiaB family, Radical SAM; Region: Elp3; smart00729
335659014235	Domain of unknown function (DUF4070); Region: DUF4070; pfam13282
335659014236	ethanolamine ammonia lyase large subunit; Provisional; Region: PRK15067
335659014237	Ethanolamine ammonia lyase large subunit (EutB); Region: EutB; pfam06751
335659014238	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054
335659014239	dimerization interface [polypeptide binding]; other site
335659014240	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
335659014241	dimer interface [polypeptide binding]; other site
335659014242	putative CheW interface [polypeptide binding]; other site
335659014243	cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664
335659014244	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cl00047
335659014245	Crp-like helix-turn-helix domain; Region: HTH_Crp_2; pfam13545
335659014246	Response regulator receiver domain; Region: Response_reg; pfam00072
335659014247	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
335659014248	active site
335659014249	phosphorylation site [posttranslational modification]
335659014250	intermolecular recognition site; other site
335659014251	dimerization interface [polypeptide binding]; other site
335659014252	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
335659014253	GAF domain; Region: GAF; pfam01590
335659014254	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920
335659014255	Histidine kinase; Region: HisKA_2; pfam07568
335659014256	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
335659014257	ATP binding site [chemical binding]; other site
335659014258	Mg2+ binding site [ion binding]; other site
335659014259	G-X-G motif; other site
335659014260	Protein-tyrosine-phosphatase [Signal transduction mechanisms]; Region: Wzb; COG0394
335659014261	Low molecular weight phosphatase family; Region: LMWPc; cl00105
335659014262	active site
335659014263	Uncharacterized conserved protein [Function unknown]; Region: COG5476
335659014264	Protein of unknown function (DUF1485); Region: DUF1485; pfam07364
335659014265	MlrC C-terminus; Region: MlrC_C; pfam07171
335659014266	Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596
335659014267	Putative lysophospholipase; Region: Hydrolase_4; pfam12146
335659014268	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
335659014269	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
335659014270	active site
335659014271	Type I periplasmic ligand-binding domain of uncharacterized ABC (ATPase Binding Cassette)-type active transport systems that are predicted to be involved in uptake of amino acids, peptides, or inorganic ions; Region: PBP1_ABC_ligand_binding_like_8; cd06343
335659014272	Periplasmic binding protein; Region: Peripla_BP_6; pfam13458
335659014273	putative ligand binding site [chemical binding]; other site
335659014274	Uncharacterized conserved protein [Function unknown]; Region: HdeD; COG3247
335659014275	Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596
335659014276	SNF2 Helicase protein; Region: DUF3670; pfam12419
335659014277	MHYT domain (predicted integral membrane sensor domain) [Signal transduction mechanisms]; Region: COG3300
335659014278	Bacterial signalling protein N terminal repeat; Region: MHYT; pfam03707
335659014279	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
335659014280	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
335659014281	metal binding site [ion binding]; metal-binding site
335659014282	active site
335659014283	I-site; other site
335659014284	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
335659014285	RNA polymerase sigma factor RpoE; Provisional; Region: PRK09652
335659014286	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
335659014287	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
335659014288	DNA binding residues [nucleotide binding]
335659014289	anti-sigma factor, putative, ChrR family; Region: anti_sig_ChrR; TIGR02451
335659014290	Putative zinc-finger; Region: zf-HC2; pfam13490
335659014291	ChrR Cupin-like domain; Region: Cupin_7; pfam12973
335659014292	RNA polymerase sigma factor; Provisional; Region: PRK12514
335659014293	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
335659014294	Sigma-70, region 4; Region: Sigma70_r4_2; pfam08281
335659014295	DNA binding residues [nucleotide binding]
335659014296	Uncharacterized protein related to deoxyribodipyrimidine photolyase [General function prediction only]; Region: COG3046
335659014297	Deoxyribodipyrimidine photo-lyase-related protein; Region: DPRP; pfam04244
335659014298	TspO/MBR family; Region: TspO_MBR; pfam03073
335659014299	aminoethylphosphonate catabolism associated LysR family transcriptional regulator; Region: phn_lysR; TIGR03339
335659014300	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
335659014301	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466
335659014302	dimerization interface [polypeptide binding]; other site
335659014303	ABC-type sugar transport systems, ATPase components [Carbohydrate transport and metabolism]; Region: MalK; COG3839
335659014304	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
335659014305	Walker A/P-loop; other site
335659014306	ATP binding site [chemical binding]; other site
335659014307	Q-loop/lid; other site
335659014308	ABC transporter signature motif; other site
335659014309	Walker B; other site
335659014310	D-loop; other site
335659014311	H-loop/switch region; other site
335659014312	TOBE domain; Region: TOBE_2; pfam08402
335659014313	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
335659014314	dimer interface [polypeptide binding]; other site
335659014315	conserved gate region; other site
335659014316	putative PBP binding loops; other site
335659014317	ABC-ATPase subunit interface; other site
335659014318	ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395
335659014319	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
335659014320	dimer interface [polypeptide binding]; other site
335659014321	conserved gate region; other site
335659014322	putative PBP binding loops; other site
335659014323	ABC-ATPase subunit interface; other site
335659014324	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653
335659014325	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199
335659014326	Enterobacter aerogenes GpdQ and related proteins, metallophosphatase domain; Region: MPP_GpdQ; cd07402
335659014327	Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149
335659014328	active site
335659014329	metal binding site [ion binding]; metal-binding site
335659014330	hexamer interface [polypeptide binding]; other site
335659014331	Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305
335659014332	Bacterial transglutaminase-like N-terminal region; Region: Bact_transglu_N; pfam08379
335659014333	Transglutaminase-like superfamily; Region: Transglut_core; pfam01841
335659014334	A circularly permuted ATPgrasp; Region: CP_ATPgrasp_1; cl17448
335659014335	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2307
335659014336	A predicted alpha-helical domain with a conserved ER motif; Region: Alpha-E; pfam04168
335659014337	Bacterial transglutaminase-like N-terminal region; Region: Bact_transglu_N; pfam08379
335659014338	Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305
335659014339	Transglutaminase-like superfamily; Region: Transglut_core; pfam01841
335659014340	Putative amidoligase enzyme (DUF2126); Region: DUF2126; pfam09899
335659014341	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4196
335659014342	Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283
335659014343	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
335659014344	dimer interface [polypeptide binding]; other site
335659014345	putative CheW interface [polypeptide binding]; other site
335659014346	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
335659014347	PAS fold; Region: PAS_3; pfam08447
335659014348	putative active site [active]
335659014349	heme pocket [chemical binding]; other site
335659014350	Domains similar to fish antifreeze type III protein; Region: SAF_AH_GD; cd11613
335659014351	galactarate dehydratase; Region: galactar-dH20; TIGR03248
335659014352	D-galactarate dehydratase / Altronate hydrolase, C terminus; Region: GD_AH_C; pfam04295
335659014353	HpcH/HpaI aldolase/citrate lyase family; Region: HpcH_HpaI; cl17231
335659014354	ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410
335659014355	ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224
335659014356	Walker A/P-loop; other site
335659014357	ATP binding site [chemical binding]; other site
335659014358	Q-loop/lid; other site
335659014359	ABC transporter signature motif; other site
335659014360	Walker B; other site
335659014361	D-loop; other site
335659014362	H-loop/switch region; other site
335659014363	ABC-type branched-chain amino acid transport system, permease component [Amino acid transport and metabolism]; Region: LivM; COG4177
335659014364	Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581
335659014365	TM-ABC transporter signature motif; other site
335659014366	ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411
335659014367	ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219
335659014368	Walker A/P-loop; other site
335659014369	ATP binding site [chemical binding]; other site
335659014370	Q-loop/lid; other site
335659014371	ABC transporter signature motif; other site
335659014372	Walker B; other site
335659014373	D-loop; other site
335659014374	H-loop/switch region; other site
335659014375	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
335659014376	Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582
335659014377	TM-ABC transporter signature motif; other site
335659014378	ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683
335659014379	Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011
335659014380	homoprotocatechuate degradation operon regulator, HpaR; Region: HpaR; TIGR02337
335659014381	Transcriptional regulators [Transcription]; Region: MarR; COG1846
335659014382	Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; cl11421
335659014383	5-carboxymethyl-2-hydroxymuconate isomerase (CHMI) is a trimeric enzyme catalyzing the isomerization of the unsaturated ketone 5-(carboxymethyl)-2-hydroxymuconate to 5-(carboxymethyl)-2-oxo-3-hexene-1,6-dionate. This is one step in the...; Region: CHMI; cd00580
335659014384	putative substrate binding pocket [chemical binding]; other site
335659014385	trimer interface [polypeptide binding]; other site
335659014386	5-carboxymethyl-2-hydroxymuconate semialdehyde dehydrogenase; Region: HpaE; TIGR02299
335659014387	Human aldehyde dehydrogenase family 8 member A1-like; Region: ALDH_F8_HMSADH; cd07093
335659014388	NAD binding site [chemical binding]; other site
335659014389	catalytic residues [active]
335659014390	3,4-dihydroxyphenylacetate 2,3-dioxygenase; Region: HpaD; TIGR02295
335659014391	N-terminal domain of 3,4-dihydroxyphenylacetate 2,3-dioxygenase (HPCD); belongs to the type I class II family of extradiol dioxygenases; Region: HPCD_N_class_II; cd07266
335659014392	tetramer interface [polypeptide binding]; other site
335659014393	C-terminal domain of 3,4-dihydroxyphenylacetate 2,3-dioxygenase (HPCD), which catalyses the second step in the degradation of 4-hydroxyphenylacetate to succinate and pyruvate; belongs to the type I class II family of extradiol dioxygenases; Region: HPCD_C_class_II; cd07256
335659014394	tetramer interface [polypeptide binding]; other site
335659014395	active site
335659014396	metal binding site [ion binding]; metal-binding site
335659014397	2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179
335659014398	Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557
335659014399	hypothetical protein; Provisional; Region: PRK08266
335659014400	Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035
335659014401	PYR/PP interface [polypeptide binding]; other site
335659014402	dimer interface [polypeptide binding]; other site
335659014403	TPP binding site [chemical binding]; other site
335659014404	Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205
335659014405	Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cd00568
335659014406	TPP-binding site [chemical binding]; other site
335659014407	TIGR02302 family protein; Region: aProt_lowcomp
335659014408	alpha-ketoglutarate-dependent dioxygenase AlkB; Provisional; Region: PRK15401
335659014409	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3826
335659014410	Transglycosylase; Region: Transgly; pfam00912
335659014411	Protein of unknown function (DUF2848); Region: DUF2848; pfam11010
335659014412	amidase; Provisional; Region: PRK07056
335659014413	Amidase; Region: Amidase; cl11426
335659014414	Predicted nucleic-acid-binding protein containing a Zn-ribbon [General function prediction only]; Region: COG1545
335659014415	Rubredoxin-like zinc ribbon domain (DUF35_N); Region: DUF35_N; pfam12172
335659014416	DUF35 OB-fold domain; Region: DUF35; pfam01796
335659014417	thiolase; Provisional; Region: PRK06158
335659014418	Thiolase domain associated with sterol carrier protein (SCP)-x isoform and related proteins; SCP-2  has multiple roles in intracellular lipid circulation and metabolism. The N-terminal presequence in the SCP-x isoform represents a peroxisomal...; Region: SCP-x_thiolase; cd00829
335659014419	active site
335659014420	3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557
335659014421	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
335659014422	NAD(P) binding site [chemical binding]; other site
335659014423	active site
335659014424	Gluconolactonase [Carbohydrate transport and metabolism]; Region: COG3386
335659014425	Strictosidine synthase; Region: Str_synth; pfam03088
335659014426	phosphoenolpyruvate carboxylase; Reviewed; Region: PRK00009
335659014427	Phosphoenolpyruvate carboxylase [Energy production and conversion]; Region: Ppc; COG2352
335659014428	Uncharacterized protein family (UPF0157); Region: UPF0157; pfam04229
335659014429	hypothetical protein; Provisional; Region: PRK11770
335659014430	Domain of unknown function (DUF307); Region: DUF307; pfam03733
335659014431	Domain of unknown function (DUF307); Region: DUF307; pfam03733
335659014432	glycogen debranching enzyme GlgX; Region: glgX_debranch; TIGR02100
335659014433	N-terminal Early set domain associated with the catalytic domain of Glycogen debranching enzyme and bacterial isoamylase (also called glycogen 6-glucanohydrolase); Region: E_set_GDE_Isoamylase_N; cd02856
335659014434	Alpha amylase catalytic domain found in glycogen debranching enzymes; Region: AmyAc_Glg_debranch; cd11326
335659014435	active site
335659014436	catalytic site [active]
335659014437	Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024
335659014438	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
335659014439	substrate binding site [chemical binding]; other site
335659014440	oxyanion hole (OAH) forming residues; other site
335659014441	trimer interface [polypeptide binding]; other site
335659014442	long-chain-fatty-acid--CoA ligase; Provisional; Region: PRK12406
335659014443	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
335659014444	Bacterial Bile acid CoA ligases and similar proteins; Region: BACL_like; cd05929
335659014445	acyl-activating enzyme (AAE) consensus motif; other site
335659014446	putative AMP binding site [chemical binding]; other site
335659014447	putative active site [active]
335659014448	putative CoA binding site [chemical binding]; other site
335659014449	enoyl-CoA hydratase; Provisional; Region: PRK07509
335659014450	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
335659014451	substrate binding site [chemical binding]; other site
335659014452	oxyanion hole (OAH) forming residues; other site
335659014453	trimer interface [polypeptide binding]; other site
335659014454	Trans-2-enoyl-CoA reductase (TER) and 2,4-dienoyl-CoA reductase (DECR), atypical (a) SDR; Region: TER_DECR_SDR_a; cd05369
335659014455	short chain dehydrogenase; Provisional; Region: PRK07677
335659014456	NAD(P) binding site [chemical binding]; other site
335659014457	substrate binding site [chemical binding]; other site
335659014458	homotetramer interface [polypeptide binding]; other site
335659014459	active site
335659014460	homodimer interface [polypeptide binding]; other site
335659014461	long-chain-fatty-acid--CoA ligase; Validated; Region: PRK06187
335659014462	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
335659014463	Bacterial Bile acid CoA ligases and similar proteins; Region: BACL_like; cd05929
335659014464	acyl-activating enzyme (AAE) consensus motif; other site
335659014465	acyl-activating enzyme (AAE) consensus motif; other site
335659014466	putative AMP binding site [chemical binding]; other site
335659014467	putative active site [active]
335659014468	putative CoA binding site [chemical binding]; other site
335659014469	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
335659014470	Acyl-CoA dehydrogenase, N-terminal domain; Region: Acyl-CoA_dh_N; pfam02771
335659014471	Acyl-CoA dehydrogenase; Region: ACAD; cd00567
335659014472	active site
335659014473	enoyl-CoA hydratase; Provisional; Region: PRK06494
335659014474	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
335659014475	substrate binding site [chemical binding]; other site
335659014476	oxyanion hole (OAH) forming residues; other site
335659014477	trimer interface [polypeptide binding]; other site
335659014478	2-enoyl-CoA Hydratase C-terminal region; Region: ECH_C; pfam13766
335659014479	Acyl-CoA dehydrogenase (ACAD) 10 and 11, N-terminal domain, and similar proteins. This subfamily is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs); Region: ACAD10_11_like; cd05154
335659014480	Phosphotransferase enzyme family; Region: APH; pfam01636
335659014481	putative active site [active]
335659014482	putative substrate binding site [chemical binding]; other site
335659014483	ATP binding site [chemical binding]; other site
335659014484	enoyl-CoA hydratase; Provisional; Region: PRK05981
335659014485	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
335659014486	substrate binding site [chemical binding]; other site
335659014487	oxyanion hole (OAH) forming residues; other site
335659014488	trimer interface [polypeptide binding]; other site
335659014489	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
335659014490	3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653
335659014491	NAD(P) binding site [chemical binding]; other site
335659014492	active site
335659014493	This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_19; cd07262
335659014494	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
335659014495	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
335659014496	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
335659014497	active site
335659014498	Conserved protein/domain typically associated with flavoprotein oxygenases, DIM6/NTAB family [General function prediction only]; Region: COG1853
335659014499	putative S-transferase; Provisional; Region: PRK11752
335659014500	GST_N family, Ure2p-like subfamily; composed of the Saccharomyces cerevisiae Ure2p and related GSTs. Ure2p is a regulator for nitrogen catabolism in yeast. It represses the expression of several gene products involved in the use of poor nitrogen sources...; Region: GST_N_Ure2p_like; cd03048
335659014501	C-terminal domain interface [polypeptide binding]; other site
335659014502	GSH binding site (G-site) [chemical binding]; other site
335659014503	dimer interface [polypeptide binding]; other site
335659014504	C-terminal, alpha helical domain of Escherichia coli Yghu Glutathione S-transferases and related uncharacterized proteins; Region: GST_C_YghU_like; cd10292
335659014505	dimer interface [polypeptide binding]; other site
335659014506	N-terminal domain interface [polypeptide binding]; other site
335659014507	active site
335659014508	Nitronate monooxygenase; Region: NMO; pfam03060
335659014509	2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730
335659014510	FMN binding site [chemical binding]; other site
335659014511	substrate binding site [chemical binding]; other site
335659014512	putative catalytic residue [active]
335659014513	acetyl-CoA acetyltransferase; Validated; Region: PRK08257
335659014514	Thiolase domain associated with sterol carrier protein (SCP)-x isoform and related proteins; SCP-2  has multiple roles in intracellular lipid circulation and metabolism. The N-terminal presequence in the SCP-x isoform represents a peroxisomal...; Region: SCP-x_thiolase; cd00829
335659014515	active site
335659014516	RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730
335659014517	HlyD family secretion protein; Region: HlyD_3; pfam13437
335659014518	Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841
335659014519	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
335659014520	PAS domain; Region: PAS_9; pfam13426
335659014521	putative active site [active]
335659014522	heme pocket [chemical binding]; other site
335659014523	Methyl-accepting chemotaxis protein (MCP) signalling domain; Region: MCPsignal; pfam00015
335659014524	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
335659014525	dimer interface [polypeptide binding]; other site
335659014526	putative CheW interface [polypeptide binding]; other site
335659014527	Nitrate and nitrite sensing; Region: NIT; pfam08376
335659014528	Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840
335659014529	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
335659014530	dimerization interface [polypeptide binding]; other site
335659014531	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
335659014532	dimer interface [polypeptide binding]; other site
335659014533	putative CheW interface [polypeptide binding]; other site
335659014534	CHASE3 domain; Region: CHASE3; pfam05227
335659014535	HAMP domain; Region: HAMP; pfam00672
335659014536	dimerization interface [polypeptide binding]; other site
335659014537	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
335659014538	dimer interface [polypeptide binding]; other site
335659014539	Methyl-accepting chemotaxis protein (MCP) signalling domain; Region: MCPsignal; pfam00015
335659014540	putative CheW interface [polypeptide binding]; other site
335659014541	Four helix bundle sensory module for signal transduction; Region: 4HB_MCP_1; pfam12729
335659014542	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
335659014543	Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283
335659014544	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
335659014545	dimer interface [polypeptide binding]; other site
335659014546	putative CheW interface [polypeptide binding]; other site
335659014547	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3395
335659014548	Hydroxypyruvate isomerase [Carbohydrate transport and metabolism]; Region: Hfi; COG3622
335659014549	3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084
335659014550	6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599
335659014551	putative aldolase; Validated; Region: PRK08130
335659014552	intersubunit interface [polypeptide binding]; other site
335659014553	active site
335659014554	Zn2+ binding site [ion binding]; other site
335659014555	ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410
335659014556	ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224
335659014557	Walker A/P-loop; other site
335659014558	ATP binding site [chemical binding]; other site
335659014559	Q-loop/lid; other site
335659014560	ABC transporter signature motif; other site
335659014561	Walker B; other site
335659014562	D-loop; other site
335659014563	H-loop/switch region; other site
335659014564	ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411
335659014565	ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219
335659014566	Walker A/P-loop; other site
335659014567	ATP binding site [chemical binding]; other site
335659014568	Q-loop/lid; other site
335659014569	ABC transporter signature motif; other site
335659014570	Walker B; other site
335659014571	D-loop; other site
335659014572	H-loop/switch region; other site
335659014573	ABC-type branched-chain amino acid transport system, permease component [Amino acid transport and metabolism]; Region: LivM; COG4177
335659014574	Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581
335659014575	TM-ABC transporter signature motif; other site
335659014576	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
335659014577	Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582
335659014578	TM-ABC transporter signature motif; other site
335659014579	ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683
335659014580	Type I periplasmic ligand-binding domain of uncharacterized ABC (ATPase Binding Cassette)-type active transport systems that are predicted to be involved in transport of amino acids, peptides, or inorganic ions; Region: PBP1_ABC_ligand_binding_like_6; cd06340
335659014581	putative ligand binding site [chemical binding]; other site
335659014582	hypothetical protein; Provisional; Region: PRK05463
335659014583	Transcriptional regulator [Transcription]; Region: LysR; COG0583
335659014584	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
335659014585	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466
335659014586	dimerization interface [polypeptide binding]; other site
335659014587	allantoate amidohydrolase; Reviewed; Region: PRK09290
335659014588	M20 Peptidase beta-alanine synthase, an amidohydrolase; Region: M20_bAS; cd03884
335659014589	active site
335659014590	metal binding site [ion binding]; metal-binding site
335659014591	dimer interface [polypeptide binding]; other site
335659014592	Lactate dehydrogenase and related dehydrogenases [Energy production and conversion / Coenzyme metabolism / General function prediction only]; Region: LdhA; COG1052
335659014593	Formate/glycerate dehydrogenases, D-specific 2-hydroxy acid dehydrogenases and related dehydrogenases; Region: FDH_GDH_like; cl17240
335659014594	NAD binding site [chemical binding]; other site
335659014595	putative dehydrogenase; Provisional; Region: PRK10098
335659014596	tartrate dehydrogenase; Region: TTC; TIGR02089
335659014597	Isocitrate/isopropylmalate dehydrogenase [Amino acid transport and metabolism]; Region: LeuB; COG0473
335659014598	short chain dehydrogenase; Provisional; Region: PRK06125
335659014599	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
335659014600	NAD(P) binding site [chemical binding]; other site
335659014601	active site
335659014602	amidase; Provisional; Region: PRK07486
335659014603	Amidase; Region: Amidase; pfam01425
335659014604	ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215
335659014605	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
335659014606	dimer interface [polypeptide binding]; other site
335659014607	conserved gate region; other site
335659014608	putative PBP binding loops; other site
335659014609	ABC-ATPase subunit interface; other site
335659014610	ABC-type amino acid transport system, permease component [Amino acid transport and metabolism]; Region: BatB; COG4597
335659014611	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
335659014612	conserved gate region; other site
335659014613	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
335659014614	putative PBP binding loops; other site
335659014615	dimer interface [polypeptide binding]; other site
335659014616	ABC-ATPase subunit interface; other site
335659014617	Transcriptional regulators [Transcription]; Region: RpiR; COG1737
335659014618	RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013
335659014619	putative active site [active]
335659014620	hypothetical protein; Provisional; Region: PRK07483
335659014621	Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610
335659014622	inhibitor-cofactor binding pocket; inhibition site
335659014623	pyridoxal 5'-phosphate binding site [chemical binding]; other site
335659014624	catalytic residue [active]
335659014625	lysine-arginine-ornithine-binding periplasmic protein; Region: 3A0103s03R; TIGR01096
335659014626	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
335659014627	substrate binding pocket [chemical binding]; other site
335659014628	membrane-bound complex binding site; other site
335659014629	hinge residues; other site
335659014630	Asp/Glu/Hydantoin racemase; Region: Asp_Glu_race; pfam01177
335659014631	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
335659014632	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
335659014633	WHG domain; Region: WHG; pfam13305
335659014634	4Fe-4S single cluster domain; Region: Fer4_15; pfam13459
335659014635	Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124
335659014636	Cytochrome P450; Region: p450; cl12078
335659014637	alpha-ketoglutarate transporter; Provisional; Region: PRK10406
335659014638	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
335659014639	putative substrate translocation pore; other site
335659014640	Sulfite oxidase and related enzymes [General function prediction only]; Region: COG2041
335659014641	bacterial and archael members of the sulfite oxidase (SO) family of molybdopterin binding domains. This molybdopterin cofactor (Moco) binding domain is found in a variety of oxidoreductases, main members of this family are nitrate reductase (NR) and...; Region: arch_bact_SO_family_Moco; cd02109
335659014642	Moco binding site; other site
335659014643	metal coordination site [ion binding]; other site
335659014644	Predicted redox protein, regulator of disulfide bond formation [Posttranslational modification, protein turnover, chaperones]; Region: COG1765
335659014645	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167
335659014646	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
335659014647	DNA-binding site [nucleotide binding]; DNA binding site
335659014648	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
335659014649	pyridoxal 5'-phosphate binding site [chemical binding]; other site
335659014650	homodimer interface [polypeptide binding]; other site
335659014651	catalytic residue [active]
335659014652	EamA-like transporter family; Region: EamA; pfam00892
335659014653	Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950
335659014654	Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912
335659014655	NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604
335659014656	NAD(P) binding site [chemical binding]; other site
335659014657	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
335659014658	phenylacetate-CoA ligase; Region: PA_CoA_ligase; TIGR02155
335659014659	acyl-activating enzyme (AAE) consensus motif; other site
335659014660	AMP binding site [chemical binding]; other site
335659014661	active site
335659014662	CoA binding site [chemical binding]; other site
335659014663	PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria.  Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443
335659014664	CoenzymeA binding site [chemical binding]; other site
335659014665	subunit interaction site [polypeptide binding]; other site
335659014666	PHB binding site; other site
335659014667	phenylacetate-CoA oxygenase/reductase, PaaK subunit; Region: PA_CoA_Oxy5; TIGR02160
335659014668	NAD(P) binding domain of ferredoxin reductase like phenylacetic acid (PA) degradation oxidoreductase. PA oxidoreductases of E. coli hydroxylate PA-CoA in the second step of PA degradation. Members of this group typically fuse a ferredoxin reductase-like...; Region: PA_degradation_oxidoreductase_like; cd06214
335659014669	FAD binding pocket [chemical binding]; other site
335659014670	FAD binding motif [chemical binding]; other site
335659014671	phosphate binding motif [ion binding]; other site
335659014672	beta-alpha-beta structure motif; other site
335659014673	NAD(p) ribose binding residues [chemical binding]; other site
335659014674	NAD binding pocket [chemical binding]; other site
335659014675	NAD(P)-pyrophosphate-nicotinamide binding residues [chemical binding]; other site
335659014676	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
335659014677	catalytic loop [active]
335659014678	iron binding site [ion binding]; other site
335659014679	Predicted metal-sulfur cluster biosynthetic enzyme [General function prediction only]; Region: PaaD; COG2151
335659014680	phenylacetate-CoA oxygenase, PaaJ subunit; Region: PA_CoA_Oxy4; TIGR02159
335659014681	Phenylacetic acid catabolic protein; Region: PaaA_PaaC; pfam05138
335659014682	phenylacetate-CoA oxygenase subunit PaaB; Provisional; Region: paaB; PRK13781
335659014683	phenylacetate-CoA oxygenase subunit PaaA; Provisional; Region: paaA; PRK13778
335659014684	phenylacetate-CoA oxygenase, PaaG subunit; Region: PA_CoA_Oxy1; TIGR02156
335659014685	PaaX-like protein; Region: PaaX; pfam07848
335659014686	phenylacetic acid degradation operon negative regulatory protein PaaX; Region: PaaX_trns_reg; TIGR02277
335659014687	PaaX-like protein C-terminal domain; Region: PaaX_C; pfam08223
335659014688	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
335659014689	PGAP1-like protein; Region: PGAP1; pfam07819
335659014690	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173
335659014691	Protein of unknown function (DUF445); Region: DUF445; pfam04286
335659014692	Phasin protein; Region: Phasin_2; cl11491
335659014693	Sortase and related acyltransferases [Cell envelope biogenesis, outer membrane]; Region: COG1247
335659014694	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
335659014695	Coenzyme A binding pocket [chemical binding]; other site
335659014696	poly(R)-hydroxyalkanoic acid synthase, class III, PhaC subunit; Region: PHA_synth_III_C; TIGR01836
335659014697	Poly-beta-hydroxybutyrate polymerase (PhaC) N-terminus; Region: PhaC_N; pfam07167
335659014698	polyhydroxyalkanoic acid synthase, PhaR subunit; Region: phaR_Bmeg; TIGR02132
335659014699	Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596
335659014700	homoserine O-acetyltransferase; Provisional; Region: metX; cl17114
335659014701	TAP-like protein; Region: Abhydrolase_4; pfam08386
335659014702	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173
335659014703	Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124
335659014704	Cytochrome P450; Region: p450; pfam00067
335659014705	Sulfite reductase, alpha subunit (flavoprotein) [Inorganic ion transport and metabolism]; Region: CysJ; COG0369
335659014706	Flavodoxin; Region: Flavodoxin_1; pfam00258
335659014707	These bifunctional proteins fuse N-terminal cytochrome p450 with a cytochrome p450 reductase (CYPOR). NADPH cytochrome p450 reductase serves as an electron donor in several oxygenase systems and is a component of nitric oxide synthases and methionine...; Region: bifunctional_CYPOR; cd06206
335659014708	FAD binding pocket [chemical binding]; other site
335659014709	FAD binding motif [chemical binding]; other site
335659014710	catalytic residues [active]
335659014711	NAD binding pocket [chemical binding]; other site
335659014712	phosphate binding motif [ion binding]; other site
335659014713	beta-alpha-beta structure motif; other site
335659014714	Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596
335659014715	Putative lysophospholipase; Region: Hydrolase_4; pfam12146
335659014716	acyltransferase, WS/DGAT/MGAT; Region: acyl_WS_DGAT; TIGR02946
335659014717	Wax ester synthase-like Acyl-CoA acyltransferase domain; Region: WES_acyltransf; pfam03007
335659014718	Protein of unknown function (DUF1298); Region: DUF1298; pfam06974
335659014719	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
335659014720	PGAP1-like protein; Region: PGAP1; pfam07819
335659014721	ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747
335659014722	The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_2; cd08498
335659014723	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601
335659014724	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
335659014725	dimer interface [polypeptide binding]; other site
335659014726	conserved gate region; other site
335659014727	putative PBP binding loops; other site
335659014728	ABC-ATPase subunit interface; other site
335659014729	nickel ABC transporter, permease subunit NikC; Region: nickel_nikC; TIGR02790
335659014730	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
335659014731	dimer interface [polypeptide binding]; other site
335659014732	conserved gate region; other site
335659014733	putative PBP binding loops; other site
335659014734	ABC-ATPase subunit interface; other site
335659014735	ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444
335659014736	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
335659014737	Walker A/P-loop; other site
335659014738	ATP binding site [chemical binding]; other site
335659014739	Q-loop/lid; other site
335659014740	ABC transporter signature motif; other site
335659014741	Walker B; other site
335659014742	D-loop; other site
335659014743	H-loop/switch region; other site
335659014744	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097
335659014745	dipeptide transporter ATP-binding subunit; Provisional; Region: dppF; PRK11308
335659014746	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
335659014747	Walker A/P-loop; other site
335659014748	ATP binding site [chemical binding]; other site
335659014749	Q-loop/lid; other site
335659014750	ABC transporter signature motif; other site
335659014751	Walker B; other site
335659014752	D-loop; other site
335659014753	H-loop/switch region; other site
335659014754	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097
335659014755	Gamma-glutamyltransferase [Amino acid transport and metabolism]; Region: Ggt; COG0405
335659014756	Gamma-glutamyltranspeptidase; Region: G_glu_transpept; pfam01019
335659014757	ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444
335659014758	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
335659014759	Walker A/P-loop; other site
335659014760	ATP binding site [chemical binding]; other site
335659014761	Q-loop/lid; other site
335659014762	ABC transporter signature motif; other site
335659014763	Walker B; other site
335659014764	D-loop; other site
335659014765	H-loop/switch region; other site
335659014766	oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727
335659014767	dipeptide transporter ATP-binding subunit; Provisional; Region: dppF; PRK11308
335659014768	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
335659014769	Walker A/P-loop; other site
335659014770	ATP binding site [chemical binding]; other site
335659014771	Q-loop/lid; other site
335659014772	ABC transporter signature motif; other site
335659014773	Walker B; other site
335659014774	D-loop; other site
335659014775	H-loop/switch region; other site
335659014776	oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727
335659014777	ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747
335659014778	The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_5; cd08511
335659014779	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601
335659014780	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
335659014781	dimer interface [polypeptide binding]; other site
335659014782	conserved gate region; other site
335659014783	putative PBP binding loops; other site
335659014784	ABC-ATPase subunit interface; other site
335659014785	nickel ABC transporter, permease subunit NikC; Region: nickel_nikC; TIGR02790
335659014786	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
335659014787	dimer interface [polypeptide binding]; other site
335659014788	conserved gate region; other site
335659014789	putative PBP binding loops; other site
335659014790	ABC-ATPase subunit interface; other site
335659014791	multidrug efflux protein; Reviewed; Region: PRK09579
335659014792	Protein export membrane protein; Region: SecD_SecF; cl14618
335659014793	RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730
335659014794	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
335659014795	HlyD family secretion protein; Region: HlyD_3; pfam13437
335659014796	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
335659014797	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
335659014798	hypothetical protein; Provisional; Region: PRK06163
335659014799	Thiamine pyrophosphate (TPP) family, ComE subfamily, TPP-binding module; composed of proteins similar to Methanococcus jannaschii sulfopyruvate decarboxylase beta subunit (ComE). M. jannaschii sulfopyruvate decarboxylase (ComDE) is a dodecamer of six...; Region: TPP_ComE; cd03372
335659014800	TPP-binding site; other site
335659014801	Pyrimidine (PYR) binding domain of thiamine pyrophosphate (TPP)-dependent enzymes; Region: TPP_enzyme_PYR; cl11410
335659014802	Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124
335659014803	Cytochrome P450; Region: p450; cl12078
335659014804	Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082
335659014805	Protein of unknown function (DUF993); Region: DUF993; pfam06187
335659014806	Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673
335659014807	Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408
335659014808	Enolase-superfamily, characterized by the presence of an enolate anion intermediate which is generated by abstraction of the alpha-proton of the carboxylate substrate by an active site residue and is stabilized by coordination to the essential Mg2+ ion; Region: enolase_like; cl17188
335659014809	metal binding site [ion binding]; metal-binding site
335659014810	ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116
335659014811	ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293
335659014812	Walker A/P-loop; other site
335659014813	ATP binding site [chemical binding]; other site
335659014814	Q-loop/lid; other site
335659014815	ABC transporter signature motif; other site
335659014816	Walker B; other site
335659014817	D-loop; other site
335659014818	H-loop/switch region; other site
335659014819	NMT1/THI5 like; Region: NMT1; pfam09084
335659014820	ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600
335659014821	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
335659014822	dimer interface [polypeptide binding]; other site
335659014823	conserved gate region; other site
335659014824	putative PBP binding loops; other site
335659014825	ABC-ATPase subunit interface; other site
335659014826	pyrimidine utilization regulatory protein R; Region: RutR; TIGR03613
335659014827	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
335659014828	This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632
335659014829	active site
335659014830	This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587
335659014831	active site
335659014832	Ribokinase-like subgroup B.  Found in bacteria and plants, this subgroup is part of the ribokinase/pfkB superfamily.  Its oligomerization state is unknown at this time; Region: ribokinase_group_B; cd01945
335659014833	Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524
335659014834	substrate binding site [chemical binding]; other site
335659014835	ATP binding site [chemical binding]; other site
335659014836	Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524
335659014837	Ribokinase catalyses the phosphorylation of ribose to ribose-5-phosphate using ATP. This reaction is the first step in the ribose metabolism. It traps ribose within the cell after uptake and also prepares the sugar for use in the synthesis of nucleotides...; Region: ribokinase; cd01174
335659014838	substrate binding site [chemical binding]; other site
335659014839	dimer interface [polypeptide binding]; other site
335659014840	ATP binding site [chemical binding]; other site
335659014841	phenylpropionate dioxygenase ferredoxin reductase subunit; Provisional; Region: PRK09754
335659014842	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
335659014843	enoyl-CoA hydratase; Provisional; Region: PRK06688
335659014844	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
335659014845	substrate binding site [chemical binding]; other site
335659014846	oxyanion hole (OAH) forming residues; other site
335659014847	trimer interface [polypeptide binding]; other site
335659014848	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
335659014849	catalytic core [active]
335659014850	DctM-like transporters; Region: DctM; pfam06808
335659014851	TRAP-type C4-dicarboxylate transport system, large permease component [Carbohydrate transport and metabolism]; Region: DctQ; COG1593
335659014852	TRAP-type C4-dicarboxylate transport system, small permease component [Carbohydrate transport and metabolism]; Region: DctM; COG3090
335659014853	TRAP-type C4-dicarboxylate transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: DctP; COG1638
335659014854	Bacterial extracellular solute-binding protein, family 7; Region: SBP_bac_7; cl15441
335659014855	dihydroxy-acid dehydratase; Validated; Region: PRK06131
335659014856	Transcriptional regulators [Transcription]; Region: FadR; COG2186
335659014857	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
335659014858	DNA-binding site [nucleotide binding]; DNA binding site
335659014859	FCD domain; Region: FCD; pfam07729
335659014860	Protein of unknown function (DUF1236); Region: DUF1236; pfam06823
335659014861	Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451
335659014862	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
335659014863	NAD(P) binding site [chemical binding]; other site
335659014864	active site
335659014865	Gluconolactonase [Carbohydrate transport and metabolism]; Region: COG3386
335659014866	Strictosidine synthase; Region: Str_synth; pfam03088
335659014867	Rhodococcus ruber 6-oxolauric acid dehydrogenase-like; Region: ALDH_CddD_SSP0762; cd07138
335659014868	Aldehyde dehydrogenase family; Region: Aldedh; pfam00171
335659014869	NAD binding site [chemical binding]; other site
335659014870	catalytic residues [active]
335659014871	Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cl01629
335659014872	TPP-binding site [chemical binding]; other site
335659014873	PYR/PP interface [polypeptide binding]; other site
335659014874	dimer interface [polypeptide binding]; other site
335659014875	TPP binding site [chemical binding]; other site
335659014876	Transketolase, pyrimidine binding domain; Region: Transket_pyr; smart00861
335659014877	Transcriptional regulators [Transcription]; Region: Lrp; COG1522
335659014878	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
335659014879	putative DNA binding site [nucleotide binding]; other site
335659014880	putative Zn2+ binding site [ion binding]; other site
335659014881	AsnC family; Region: AsnC_trans_reg; pfam01037
335659014882	polyphosphate kinase 2, PA0141 family; Region: PPK2_P_aer; TIGR03707
335659014883	Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063
335659014884	Alcohol dehydrogenases of the MDR family; Region: Zn_ADH8; cd08262
335659014885	putative NAD(P) binding site [chemical binding]; other site
335659014886	catalytic Zn binding site [ion binding]; other site
335659014887	Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697
335659014888	EamA-like transporter family; Region: EamA; pfam00892
335659014889	EamA-like transporter family; Region: EamA; pfam00892
335659014890	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
335659014891	Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248
335659014892	active site
335659014893	catalytic tetrad [active]
335659014894	SMP-30/Gluconolaconase/LRE-like region; Region: SGL; pfam08450
335659014895	Anaerobic dehydrogenases, typically selenocysteine-containing [Energy production and conversion]; Region: BisC; COG0243
335659014896	Nitrate reductases, NapA (Nitrate-R-NapA), NasA, and NarB catalyze the reduction of nitrate to nitrite. Monomeric Nas is located in the cytoplasm and participates in nitrogen assimilation. Dimeric Nap is located in the periplasm and is coupled to quinol...; Region: MopB_Nitrate-R-NapA-like; cd02754
335659014897	[4Fe-4S] binding site [ion binding]; other site
335659014898	molybdopterin cofactor binding site; other site
335659014899	Nitrate reductases, NapA (Nitrate-R-NapA), NasA, and NarB catalyze the reduction of nitrate to nitrite. Monomeric Nas is located in the cytoplasm and participates in nitrogen assimilation. Dimeric Nap is located in the periplasm and is coupled to quinol...; Region: MopB_CT_Nitrate-R-NapA-like; cd02791
335659014900	molybdopterin cofactor binding site; other site
335659014901	BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324
335659014902	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_2; pfam07992
335659014903	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
335659014904	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
335659014905	Globins are heme proteins, which bind and transport oxygen. This family summarizes a diverse set of homologous protein domains, including: (1) tetrameric vertebrate hemoglobins, which are the major protein component of erythrocytes and transport oxygen...; Region: globin; cd01040
335659014906	heme-binding site [chemical binding]; other site
335659014907	ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116
335659014908	ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293
335659014909	Walker A/P-loop; other site
335659014910	ATP binding site [chemical binding]; other site
335659014911	Q-loop/lid; other site
335659014912	ABC transporter signature motif; other site
335659014913	Walker B; other site
335659014914	D-loop; other site
335659014915	H-loop/switch region; other site
335659014916	ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600
335659014917	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
335659014918	dimer interface [polypeptide binding]; other site
335659014919	conserved gate region; other site
335659014920	putative PBP binding loops; other site
335659014921	ABC-ATPase subunit interface; other site
335659014922	ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components [Inorganic ion transport and metabolism]; Region: TauA; COG0715
335659014923	NMT1-like family; Region: NMT1_2; pfam13379
335659014924	Cytidylyltransferase family; Region: CTP_transf_1; cl17467
335659014925	Formate/nitrite transporter; Region: Form_Nir_trans; pfam01226
335659014926	Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cd00143
335659014927	active site
335659014928	Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220
335659014929	Catalytic domain of Protein Kinases; Region: PKc; cd00180
335659014930	active site
335659014931	ATP binding site [chemical binding]; other site
335659014932	substrate binding site [chemical binding]; other site
335659014933	activation loop (A-loop); other site
335659014934	Hydroxyquinol 1,2-dioxygenase (1,2-HQD) catalyzes the ring cleavage of hydroxyquinol (1,2,4-trihydroxybenzene), a intermediate in the degradation of a large variety of aromatic compounds including some polychloro- and nitroaromatic pollutants, to form...; Region: 1,2-HQD; cd03461
335659014935	catechol 1,2-dioxygenase, proteobacterial; Region: catechol_proteo; TIGR02439
335659014936	dimer interface [polypeptide binding]; other site
335659014937	active site
335659014938	Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680
335659014939	Beta-lactamase; Region: Beta-lactamase; pfam00144
335659014940	Protein of unknown function (DUF1236); Region: DUF1236; pfam06823
335659014941	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920
335659014942	HWE histidine kinase; Region: HWE_HK; pfam07536
335659014943	Uncharacterized bacterial family of heme peroxidases; Region: An_peroxidase_bacterial_1; cd09819
335659014944	putative heme binding site [chemical binding]; other site
335659014945	putative substrate binding site [chemical binding]; other site
335659014946	Cytochrome c biogenesis protein [Posttranslational modification, protein turnover, chaperones]; Region: CcdA; COG0785
335659014947	Cytochrome C biogenesis protein transmembrane region; Region: DsbD; pfam02683
335659014948	Transcriptional regulator [Transcription]; Region: LysR; COG0583
335659014949	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
335659014950	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
335659014951	dimerization interface [polypeptide binding]; other site
335659014952	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
335659014953	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
335659014954	non-specific DNA binding site [nucleotide binding]; other site
335659014955	salt bridge; other site
335659014956	sequence-specific DNA binding site [nucleotide binding]; other site
335659014957	enoyl-CoA hydratase; Provisional; Region: PRK06127
335659014958	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
335659014959	substrate binding site [chemical binding]; other site
335659014960	oxyanion hole (OAH) forming residues; other site
335659014961	trimer interface [polypeptide binding]; other site
335659014962	2-enoyl-CoA Hydratase C-terminal region; Region: ECH_C; pfam13766
335659014963	Isocitrate/isopropylmalate dehydrogenase [Amino acid transport and metabolism]; Region: LeuB; COG0473
335659014964	tartrate dehydrogenase; Region: TTC; TIGR02089
335659014965	6-hydroxyhexanoate dehydrogenase; Region: 6_hydroxyhexanoate_dh_like; cd08240
335659014966	Zn-dependent alcohol dehydrogenases [General function prediction only]; Region: AdhP; COG1064
335659014967	putative NAD(P) binding site [chemical binding]; other site
335659014968	catalytic Zn binding site [ion binding]; other site
335659014969	oligopeptide ABC transporter ATP-binding protein OppF; Provisional; Region: PRK15079
335659014970	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
335659014971	Walker A/P-loop; other site
335659014972	ATP binding site [chemical binding]; other site
335659014973	Q-loop/lid; other site
335659014974	ABC transporter signature motif; other site
335659014975	Walker B; other site
335659014976	D-loop; other site
335659014977	H-loop/switch region; other site
335659014978	oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727
335659014979	ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444
335659014980	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
335659014981	Walker A/P-loop; other site
335659014982	ATP binding site [chemical binding]; other site
335659014983	Q-loop/lid; other site
335659014984	ABC transporter signature motif; other site
335659014985	Walker B; other site
335659014986	D-loop; other site
335659014987	H-loop/switch region; other site
335659014988	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097
335659014989	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173
335659014990	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
335659014991	putative PBP binding loops; other site
335659014992	dimer interface [polypeptide binding]; other site
335659014993	ABC-ATPase subunit interface; other site
335659014994	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601
335659014995	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
335659014996	dimer interface [polypeptide binding]; other site
335659014997	conserved gate region; other site
335659014998	putative PBP binding loops; other site
335659014999	ABC-ATPase subunit interface; other site
335659015000	ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747
335659015001	The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cl01709
335659015002	Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804
335659015003	CoA-transferase family III; Region: CoA_transf_3; pfam02515
335659015004	glycogen synthase; Provisional; Region: glgA; PRK00654
335659015005	This family is most closely related to the GT1 family of glycosyltransferases. Glycogen synthase catalyzes the formation and elongation of the alpha-1,4-glucose backbone using ADP-glucose, the second and key step of glycogen biosynthesis. This family...; Region: GT1_Glycogen_synthase_DULL1_like; cd03791
335659015006	homodimer interface [polypeptide binding]; other site
335659015007	ADP-binding pocket [chemical binding]; other site
335659015008	Uncharacterized protein conserved in bacteria (DUF2236); Region: DUF2236; pfam09995
335659015009	Hypothetical patatin similar to Z1214 protein of Escherichia coli; Region: Pat_hypo_Ecoli_Z1214_like; cd07209
335659015010	Predicted esterase of the alpha-beta hydrolase superfamily [General function prediction only]; Region: RssA; COG1752
335659015011	nucleophile elbow; other site
335659015012	Patatin phospholipase; Region: DUF3734; pfam12536
335659015013	Transcriptional regulator [Transcription]; Region: LysR; COG0583
335659015014	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
335659015015	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466
335659015016	dimerization interface [polypeptide binding]; other site
335659015017	Peroxiredoxin (PRX)-like 2 family; hypothetical proteins that show sequence similarity to PRXs. Members of this group contain a CXXC motif, similar to TRX. The second cysteine in the motif corresponds to the peroxidatic cysteine of PRX, however, these...; Region: PRX_like2; cd02970
335659015018	putative catalytic residues [active]
335659015019	Uncharacterized conserved protein, contains double-stranded beta-helix domain [Function unknown]; Region: COG1917
335659015020	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
335659015021	Major Facilitator Superfamily; Region: MFS_1; pfam07690
335659015022	putative substrate translocation pore; other site
335659015023	Cytochrome oxidase maturation protein cbb3-type; Region: CcoS; cl01253
335659015024	Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371
335659015025	metal-binding site [ion binding]
335659015026	copper-(or silver)-translocating P-type ATPase; Region: ATPase-IB1_Cu; TIGR01511
335659015027	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
335659015028	Soluble P-type ATPase [General function prediction only]; Region: COG4087
335659015029	FixH; Region: FixH; pfam05751
335659015030	Predicted integral membrane protein linked to a cation pump [Inorganic ion transport and metabolism]; Region: COG5456
335659015031	cytochrome c oxidase accessory protein FixG; Region: ccoG_rdxA_fixG; TIGR02745
335659015032	4Fe-4S binding domain; Region: Fer4_5; pfam12801
335659015033	The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655
335659015034	Ubp3 associated protein Bre5; Region: Bre5; pfam11614
335659015035	cytochrome c oxidase, cbb3-type, subunit III; Region: ccoP; TIGR00782
335659015036	Cytochrome c; Region: Cytochrom_C; pfam00034
335659015037	Cytochrome C oxidase, cbb3-type, subunit III; Region: Cytochrome_CBB3; pfam13442
335659015038	Cytochrome cbb oxidase CcoQ.  Cytochrome cbb3 oxidase, the terminal oxidase in the respiratory chains of proteobacteria, is a multi-chain transmembrane protein located in the cell membrane. Like other cytochrome oxidases, it catalyzes the reduction of O2...; Region: cbb3_Oxidase_CcoQ; cd01324
335659015039	Cbb3-type cytochrome oxidase, cytochrome c subunit [Energy production and conversion]; Region: CcoO; COG2993
335659015040	Cytochrome C oxidase, mono-heme subunit/FixO; Region: FixO; pfam02433
335659015041	Cytochrome cbb3 oxidase subunit I.  Cytochrome cbb3 oxidase, the terminal oxidase in the respiratory chains of proteobacteria, is a multi-chain transmembrane protein located in the cell membrane. Like other cytochrome oxidases, it catalyzes the reduction...; Region: cbb3_Oxidase_I; cd01661
335659015042	Low-spin heme binding site [chemical binding]; other site
335659015043	Cytochrome C and Quinol oxidase polypeptide I; Region: COX1; pfam00115
335659015044	Putative water exit pathway; other site
335659015045	Binuclear center (active site) [active]
335659015046	Putative proton exit pathway; other site
335659015047	FOG: CBS domain [General function prediction only]; Region: COG0517
335659015048	The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cd02205
335659015049	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
335659015050	Ligand Binding Site [chemical binding]; other site
335659015051	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
335659015052	PAS fold; Region: PAS_3; pfam08447
335659015053	putative active site [active]
335659015054	heme pocket [chemical binding]; other site
335659015055	PAS domain S-box; Region: sensory_box; TIGR00229
335659015056	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
335659015057	putative active site [active]
335659015058	heme pocket [chemical binding]; other site
335659015059	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
335659015060	dimer interface [polypeptide binding]; other site
335659015061	phosphorylation site [posttranslational modification]
335659015062	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
335659015063	ATP binding site [chemical binding]; other site
335659015064	Mg2+ binding site [ion binding]; other site
335659015065	G-X-G motif; other site
335659015066	response regulator FixJ; Provisional; Region: fixJ; PRK09390
335659015067	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
335659015068	active site
335659015069	phosphorylation site [posttranslational modification]
335659015070	intermolecular recognition site; other site
335659015071	dimerization interface [polypeptide binding]; other site
335659015072	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
335659015073	DNA binding residues [nucleotide binding]
335659015074	dimerization interface [polypeptide binding]; other site
335659015075	Response regulator receiver domain; Region: Response_reg; pfam00072
335659015076	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
335659015077	active site
335659015078	phosphorylation site [posttranslational modification]
335659015079	intermolecular recognition site; other site
335659015080	dimerization interface [polypeptide binding]; other site
335659015081	transcriptional regulator FixK; Provisional; Region: fixK; PRK09391
335659015082	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
335659015083	ligand binding site [chemical binding]; other site
335659015084	flexible hinge region; other site
335659015085	helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092
335659015086	putative switch regulator; other site
335659015087	non-specific DNA interactions [nucleotide binding]; other site
335659015088	DNA binding site [nucleotide binding]
335659015089	sequence specific DNA binding site [nucleotide binding]; other site
335659015090	putative cAMP binding site [chemical binding]; other site
335659015091	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
335659015092	Major Facilitator Superfamily; Region: MFS_1; pfam07690
335659015093	putative substrate translocation pore; other site
335659015094	PRC-barrel domain; Region: PRC; pfam05239
335659015095	Glycogen debranching enzyme [Carbohydrate transport and metabolism]; Region: GDB1; COG3408
335659015096	Amylo-alpha-1,6-glucosidase; Region: GDE_C; pfam06202
335659015097	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
335659015098	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
335659015099	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
335659015100	Walker A/P-loop; other site
335659015101	ATP binding site [chemical binding]; other site
335659015102	Q-loop/lid; other site
335659015103	ABC transporter signature motif; other site
335659015104	Walker B; other site
335659015105	D-loop; other site
335659015106	H-loop/switch region; other site
335659015107	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
335659015108	This family is most closely related to the GT1 family of glycosyltransferases. aviGT4 in Streptomyces viridochromogenes has been shown to be involved in biosynthesis of oligosaccharide antibiotic avilamycin A. Inactivation of aviGT4 resulted in a mutant...; Region: GT1_AviGT4_like; cd03802
335659015109	putative ADP-binding pocket [chemical binding]; other site
335659015110	Alkyl sulfatase and related hydrolases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2015
335659015111	Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849
335659015112	Tripartite ATP-independent periplasmic transporters, DctQ component; Region: DctQ; pfam04290
335659015113	DctM-like transporters; Region: DctM; pfam06808
335659015114	TRAP transporter, DctM subunit; Region: dctM; TIGR00786
335659015115	TRAP-type C4-dicarboxylate transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: DctP; COG1638
335659015116	Bacterial extracellular solute-binding protein, family 7; Region: SBP_bac_7; pfam03480
335659015117	Trans-aconitate methyltransferase [General function prediction only]; Region: Tam; COG4106
335659015118	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
335659015119	S-adenosylmethionine binding site [chemical binding]; other site
335659015120	3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653
335659015121	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
335659015122	NAD(P) binding site [chemical binding]; other site
335659015123	active site
335659015124	Rifampin ADP-ribosyl transferase; Region: Arr-ms; pfam12120
335659015125	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
335659015126	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
335659015127	The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_16; cd08502
335659015128	ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747
335659015129	putative amidase; Provisional; Region: PRK06169
335659015130	Amidase; Region: Amidase; pfam01425
335659015131	Glutamate-1-semialdehyde aminotransferase [Coenzyme metabolism]; Region: HemL; COG0001
335659015132	Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321
335659015133	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
335659015134	catalytic residue [active]
335659015135	Isocitrate/isopropylmalate dehydrogenase [Amino acid transport and metabolism]; Region: LeuB; COG0473
335659015136	tartrate dehydrogenase; Region: TTC; TIGR02089
335659015137	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
335659015138	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
335659015139	B12 binding domain (B12-BD). Most of the members bind different cobalamid derivates, like B12 (adenosylcobamide) or methylcobalamin or methyl-Co(III) 5-hydroxybenzimidazolylcobamide. This domain is found in several enzymes, such as glutamate mutase; Region: B12-binding_like; cl00293
335659015140	B12 binding site [chemical binding]; other site
335659015141	Elongator protein 3, MiaB family, Radical SAM; Region: Elp3; smart00729
335659015142	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
335659015143	FeS/SAM binding site; other site
335659015144	Domain of unknown function (DUF4070); Region: DUF4070; pfam13282
335659015145	Aerobic-type carbon monoxide dehydrogenase, small subunit CoxS/CutS homologs [Energy production and conversion]; Region: CoxS; COG2080
335659015146	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
335659015147	catalytic loop [active]
335659015148	iron binding site [ion binding]; other site
335659015149	[2Fe-2S] binding domain; Region: Fer2_2; pfam01799
335659015150	Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738
335659015151	Aerobic-type carbon monoxide dehydrogenase, large subunit CoxL/CutL homologs [Energy production and conversion]; Region: CoxL; COG1529
335659015152	Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; smart01008
335659015153	Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738
335659015154	Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738
335659015155	Uncharacterized NAD(FAD)-dependent dehydrogenases [General function prediction only]; Region: HcaD; COG0446
335659015156	Flavocytochrome c sulphide dehydrogenase, flavin-binding; Region: FCSD-flav_bind; pfam09242
335659015157	Cytochrome c; Region: Cytochrom_C; pfam00034
335659015158	sulfur oxidation protein SoxY; Provisional; Region: PRK07474
335659015159	Sulfur oxidation protein SoxY; Region: SoxY; pfam13501
335659015160	Sulphur oxidation protein SoxZ; Region: SoxZ; pfam08770
335659015161	Cytochrome c [Energy production and conversion]; Region: COG3258
335659015162	Cytochrome c [Energy production and conversion]; Region: COG3258
335659015163	Xanthine/uracil/vitamin C permease [Nucleotide transport and    metabolism]; Region: COG2252
335659015164	Isochorismatase family; Region: Isochorismatase; pfam00857
335659015165	Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cd00431
335659015166	catalytic triad [active]
335659015167	conserved cis-peptide bond; other site
335659015168	indolepyruvate ferredoxin oxidoreductase; Validated; Region: PRK09193
335659015169	Pyrimidine (PYR) binding domain of pyruvate ferredoxin oxidoreductase (PFOR), indolepyruvate ferredoxin oxidoreductase alpha subunit (IOR-alpha), and related proteins; Region: TPP_PYR_PFOR_IOR-alpha_like; cd07034
335659015170	dimer interface [polypeptide binding]; other site
335659015171	PYR/PP interface [polypeptide binding]; other site
335659015172	TPP binding site [chemical binding]; other site
335659015173	substrate binding site [chemical binding]; other site
335659015174	Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cl01629
335659015175	TPP-binding site [chemical binding]; other site
335659015176	Pyruvate:ferredoxin oxidoreductase and related 2-oxoacid:ferredoxin oxidoreductases, gamma subunit [Energy production and conversion]; Region: PorG; COG1014
335659015177	putative FAD-binding dehydrogenase; Reviewed; Region: PRK12843
335659015178	Predicted oxidoreductase [General function prediction only]; Region: COG3573
335659015179	periplasmic serine pepetdase DegS; Region: protease_degS; TIGR02038
335659015180	Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365
335659015181	PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987
335659015182	protein binding site [polypeptide binding]; other site
335659015183	Choline dehydrogenase and related flavoproteins [Amino acid transport and metabolism]; Region: BetA; COG2303
335659015184	GMC oxidoreductase; Region: GMC_oxred_C; pfam05199
335659015185	Micrococcal nuclease (thermonuclease) homologs [DNA replication, recombination, and repair]; Region: COG1525
335659015186	Staphylococcal nuclease homologues. SNase homologues are found in bacteria, archaea, and eukaryotes. They contain no disufide bonds; Region: SNc; cl00140
335659015187	Catalytic site; other site
335659015188	suhB as predicted by Rfam v8.1 (RF00519), score 50.5
335659015189	cytochrome o ubiquinol oxidase subunit IV; Region: CyoD; TIGR02847
335659015190	Ubiquinol oxidase subunit III subfamily. Ubiquinol oxidase, the terminal oxidase in the respiratory chains of aerobic bacteria, is a multi-chain transmembrane protein located in the cell membrane.  It catalyzes the reduction of O2 and simultaneously...; Region: Ubiquinol_oxidase_III; cd02863
335659015191	Subunit I/III interface [polypeptide binding]; other site
335659015192	Subunit III/IV interface [polypeptide binding]; other site
335659015193	Heme/copper-type cytochrome/quinol oxidases, subunit 1 [Energy production and conversion]; Region: CyoB; COG0843
335659015194	Ubiquinol oxidase subunit I.  Ubiquinol oxidase, the terminal oxidase in the respiratory chains of aerobic bacteria, is a multi-chain transmembrane protein located in the cell membrane.  It catalyzes the reduction of O2 and simultaneously pumps protons...; Region: Ubiquinol_Oxidase_I; cd01662
335659015195	D-pathway; other site
335659015196	Putative ubiquinol binding site [chemical binding]; other site
335659015197	Low-spin heme (heme b) binding site [chemical binding]; other site
335659015198	Putative water exit pathway; other site
335659015199	Binuclear center (heme o3/CuB) [ion binding]; other site
335659015200	K-pathway; other site
335659015201	Putative proton exit pathway; other site
335659015202	cytochrome o ubiquinol oxidase subunit II; Region: CyoA; TIGR01433
335659015203	Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; pfam00116
335659015204	classical (c) SDRs; Region: SDR_c; cd05233
335659015205	3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653
335659015206	NAD(P) binding site [chemical binding]; other site
335659015207	active site
335659015208	uncharacterized peroxidase-related enzyme; Region: peroxid_rel; TIGR01926
335659015209	Carboxymuconolactone decarboxylase family; Region: CMD; pfam02627
335659015210	3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653
335659015211	classical (c) SDRs; Region: SDR_c; cd05233
335659015212	NAD(P) binding site [chemical binding]; other site
335659015213	active site
335659015214	dehydrogenase, PQQ-dependent, s-GDH family; Region: non_repeat_PQQ; TIGR03606
335659015215	Glucose / Sorbosone dehydrogenase; Region: GSDH; pfam07995
335659015216	Protein of unknown function (DUF989); Region: DUF989; pfam06181
335659015217	Predicted membrane protein [Function unknown]; Region: COG3748
335659015218	Cytochrome c; Region: Cytochrom_C; pfam00034
335659015219	Glyoxalase-like domain; Region: Glyoxalase_3; pfam13468
335659015220	Tripartite tricarboxylate transporter family receptor; Region: TctC; cl17792
335659015221	Uncharacterized conserved protein [Function unknown]; Region: COG5484
335659015222	multidrug efflux system subunit MdtB; Provisional; Region: PRK10503
335659015223	RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730
335659015224	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
335659015225	HlyD family secretion protein; Region: HlyD_3; pfam13437
335659015226	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
335659015227	Major Facilitator Superfamily; Region: MFS_1; pfam07690
335659015228	putative substrate translocation pore; other site
335659015229	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
335659015230	GAF domain; Region: GAF; cl17456
335659015231	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
335659015232	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
335659015233	dimer interface [polypeptide binding]; other site
335659015234	phosphorylation site [posttranslational modification]
335659015235	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
335659015236	ATP binding site [chemical binding]; other site
335659015237	Mg2+ binding site [ion binding]; other site
335659015238	G-X-G motif; other site
335659015239	Response regulator receiver domain; Region: Response_reg; pfam00072
335659015240	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
335659015241	active site
335659015242	phosphorylation site [posttranslational modification]
335659015243	intermolecular recognition site; other site
335659015244	dimerization interface [polypeptide binding]; other site
335659015245	Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876
335659015246	peptidase T-like protein; Region: PepT-like; TIGR01883
335659015247	metal binding site [ion binding]; metal-binding site
335659015248	L-alanine-DL-glutamate epimerase and related enzymes of enolase superfamily [Cell envelope biogenesis, outer membrane / General function prediction only]; Region: COG4948
335659015249	Mandelate racemase (MR)-like subfamily of the enolase superfamily. Enzymes of this subgroup share three conserved carboxylate ligands for the essential divalent metal ion (usually Mg2+), two aspartates and a glutamate, and conserved catalytic residues; Region: MR_like; cd03316
335659015250	active site pocket [active]
335659015251	Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473
335659015252	M20 Peptidase Aminoacylase 1 subfamily; Region: M20_Acy1_like1; cd05666
335659015253	metal binding site [ion binding]; metal-binding site
335659015254	putative dimer interface [polypeptide binding]; other site
335659015255	Isochorismatase family; Region: Isochorismatase; pfam00857
335659015256	Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cd00431
335659015257	catalytic triad [active]
335659015258	conserved cis-peptide bond; other site
335659015259	Protein of unknown function (DUF2934); Region: DUF2934; pfam11154
335659015260	YciF bacterial stress response protein, ferritin-like iron-binding domain; Region: YciF; cd07909
335659015261	dimerization interface [polypeptide binding]; other site
335659015262	metal binding site [ion binding]; metal-binding site
335659015263	Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804
335659015264	CoA-transferase family III; Region: CoA_transf_3; pfam02515
335659015265	NHLM bacteriocin system ABC transporter, ATP-binding protein; Region: NHLM_micro_ABC2; TIGR03797
335659015266	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
335659015267	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
335659015268	Walker A/P-loop; other site
335659015269	ATP binding site [chemical binding]; other site
335659015270	Q-loop/lid; other site
335659015271	ABC transporter signature motif; other site
335659015272	Walker B; other site
335659015273	D-loop; other site
335659015274	H-loop/switch region; other site
335659015275	NHLM bacteriocin system ABC transporter, peptidase/ATP-binding protein; Region: NHLM_micro_ABC1; TIGR03796
335659015276	Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the "double-glycine" leader peptides from the precursors of various bacteriocins (mostly non-lantibiotic); Region: Peptidase_C39_like; cl00296
335659015277	putative active site [active]
335659015278	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
335659015279	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
335659015280	Walker A/P-loop; other site
335659015281	ATP binding site [chemical binding]; other site
335659015282	Q-loop/lid; other site
335659015283	ABC transporter signature motif; other site
335659015284	Walker B; other site
335659015285	D-loop; other site
335659015286	H-loop/switch region; other site
335659015287	NHLM bacteriocin system secretion protein; Region: NHLM_micro_HlyD; TIGR03794
335659015288	HlyD family secretion protein; Region: HlyD_3; pfam13437
335659015289	Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628
335659015290	Domain of unknown function DUF20; Region: UPF0118; pfam01594
335659015291	Amino acid permease; Region: AA_permease_2; pfam13520
335659015292	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
335659015293	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
335659015294	active site
335659015295	Acetyl-CoA dehydrogenase C-terminal like; Region: Acyl-CoA_dh_C; pfam12806
335659015296	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
335659015297	oxalate/formate antiporter family transporter; Region: 2A0111; TIGR00890
335659015298	putative substrate translocation pore; other site
335659015299	enoyl-CoA hydratase; Provisional; Region: PRK06688
335659015300	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
335659015301	substrate binding site [chemical binding]; other site
335659015302	oxyanion hole (OAH) forming residues; other site
335659015303	trimer interface [polypeptide binding]; other site
335659015304	5'-nucleotidase/2',3'-cyclic phosphodiesterase and related esterases [Nucleotide transport and metabolism]; Region: UshA; COG0737
335659015305	Bacillus subtilis YhcR endonuclease and related proteins, N-terminal metallophosphatase domain; Region: MPP_YhcR_N; cd07412
335659015306	putative active site [active]
335659015307	putative metal binding site [ion binding]; other site
335659015308	5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872
335659015309	Deacetylases, including yeast histone deacetylase and acetoin utilization protein [Chromatin structure and dynamics / Secondary metabolites biosynthesis, transport, and catabolism]; Region: AcuC; COG0123
335659015310	Histone deacetylases and histone-like deacetylases, classII; Region: HDAC_classII_2; cd11599
335659015311	putative active site [active]
335659015312	Zn binding site [ion binding]; other site
335659015313	exodeoxyribonuclease VII small subunit; Provisional; Region: PRK00977
335659015314	1-deoxy-D-xylulose-5-phosphate synthase; Provisional; Region: PRK05444
335659015315	Thiamine pyrophosphate (TPP) family, DXS subfamily, TPP-binding module; 1-Deoxy-D-xylulose-5-phosphate synthase (DXS) is a regulatory enzyme of the mevalonate-independent pathway involved in terpenoid biosynthesis. Terpeniods are plant natural products...; Region: TPP_DXS; cd02007
335659015316	TPP-binding site; other site
335659015317	Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033
335659015318	PYR/PP interface [polypeptide binding]; other site
335659015319	dimer interface [polypeptide binding]; other site
335659015320	TPP binding site [chemical binding]; other site
335659015321	Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780
335659015322	Nucleoside 2-deoxyribosyltransferase; Region: Nuc_deoxyrib_tr; pfam05014
335659015323	Predicted rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: COG1189
335659015324	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
335659015325	RNA binding surface [nucleotide binding]; other site
335659015326	FtsJ-like methyltransferase; Region: FtsJ; pfam01728
335659015327	SAM-dependent methyltransferases related to tRNA (uracil-5-)-methyltransferase [Translation, ribosomal structure and biogenesis]; Region: TrmA; COG2265
335659015328	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
335659015329	S-adenosylmethionine binding site [chemical binding]; other site
335659015330	Proteins of this family catalyze the reduction of flavin or nitrocompounds using NAD(P)H as electron donor in a obligatory two-electron transfer,  utilizing FMN or FAD as cofactor. They are often found to be homodimers. Enzymes of this family are...; Region: Nitro_FMN_reductase; cl00514
335659015331	dimer interface [polypeptide binding]; other site
335659015332	Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198
335659015333	metal ion-dependent adhesion site (MIDAS); other site
335659015334	Major Facilitator Superfamily; Region: MFS_1; pfam07690
335659015335	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
335659015336	putative substrate translocation pore; other site
335659015337	camphor resistance protein CrcB; Provisional; Region: PRK14195
335659015338	ATP-dependent Clp protease adaptor protein ClpS; Region: ClpS; cl00933
335659015339	Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114
335659015340	cyclase homology domain; Region: CHD; cd07302
335659015341	nucleotidyl binding site; other site
335659015342	metal binding site [ion binding]; metal-binding site
335659015343	dimer interface [polypeptide binding]; other site
335659015344	Chorismate synthase [Amino acid transport and metabolism]; Region: AroC; COG0082
335659015345	Chorismase synthase, the enzyme catalyzing the final step of the shikimate pathway; Region: Chorismate_synthase; cd07304
335659015346	Tetramer interface [polypeptide binding]; other site
335659015347	active site
335659015348	FMN-binding site [chemical binding]; other site
335659015349	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
335659015350	catalytic core [active]
335659015351	enoyl-(acyl carrier protein) reductase; Provisional; Region: PRK08159
335659015352	Enoyl acyl carrier protein (ACP) reductase (ENR), divergent SDR; Region: ENR_SDR; cd05372
335659015353	NAD binding site [chemical binding]; other site
335659015354	homotetramer interface [polypeptide binding]; other site
335659015355	homodimer interface [polypeptide binding]; other site
335659015356	substrate binding site [chemical binding]; other site
335659015357	active site
335659015358	DNA-directed RNA polymerase specialized sigma subunit, sigma24 homolog [Transcription]; Region: RpoE; COG1595
335659015359	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
335659015360	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
335659015361	DNA binding residues [nucleotide binding]
335659015362	Predicted transmembrane transcriptional regulator (anti-sigma factor) [Transcription]; Region: COG5662
335659015363	curved DNA-binding protein CbpA; Provisional; Region: PRK10266
335659015364	DnaJ domain or J-domain.  DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257
335659015365	HSP70 interaction site [polypeptide binding]; other site
335659015366	C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747
335659015367	substrate binding site [polypeptide binding]; other site
335659015368	dimer interface [polypeptide binding]; other site
335659015369	pyridoxamine 5'-phosphate oxidase; Provisional; Region: PRK05679
335659015370	Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_oxidase; pfam01243
335659015371	Pyridoxine 5'-phosphate oxidase C-terminal dimerisation region; Region: PNPOx_C; pfam10590
335659015372	Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: FabG; COG1028
335659015373	classical (c) SDRs; Region: SDR_c; cd05233
335659015374	NAD(P) binding site [chemical binding]; other site
335659015375	active site
335659015376	Mg2+ and Co2+ transporters [Inorganic ion transport and metabolism]; Region: CorA; COG0598
335659015377	uncharacterized subgroup of the Escherichia coli Mg2+ transporter CorA_like subfamily; Region: EcCorA-like_u1; cd12837
335659015378	Cl binding site [ion binding]; other site
335659015379	oligomer interface [polypeptide binding]; other site
335659015380	Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376
335659015381	L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734
335659015382	Extensin-like protein C-terminus; Region: Extensin-like_C; pfam06904
335659015383	putative acyl-CoA synthetase; Provisional; Region: PRK06018
335659015384	Fatty acyl-CoA synthetases similar to LC-FACS from Thermus thermophiles; Region: ttLC_FACS_AlkK_like; cd12119
335659015385	dimer interface [polypeptide binding]; other site
335659015386	acyl-activating enzyme (AAE) consensus motif; other site
335659015387	putative active site [active]
335659015388	AMP binding site [chemical binding]; other site
335659015389	putative CoA binding site [chemical binding]; other site
335659015390	Protein of unknown function (DUF1499); Region: DUF1499; pfam07386
335659015391	Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849
335659015392	Glutaryl-CoA dehydrogenase; Region: GCD; cd01151
335659015393	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
335659015394	FAD binding site [chemical binding]; other site
335659015395	substrate binding pocket [chemical binding]; other site
335659015396	catalytic base [active]
335659015397	bifunctional 3,4-dihydroxy-2-butanone 4-phosphate synthase/GTP cyclohydrolase II protein; Provisional; Region: PRK09311
335659015398	3,4-dihydroxy-2-butanone 4-phosphate synthase; Region: DHBP_synthase; pfam00926
335659015399	GTP cyclohydrolase II; Region: GTP_cyclohydro2; pfam00925
335659015400	dimerization interface [polypeptide binding]; other site
335659015401	active site
335659015402	Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; COG0475
335659015403	Sodium/hydrogen exchanger family; Region: Na_H_Exchanger; pfam00999
335659015404	Kef-type K+ transport systems, predicted NAD-binding component [Inorganic ion transport and metabolism]; Region: Kch; COG1226
335659015405	TrkA-N domain; Region: TrkA_N; pfam02254
335659015406	Protein of unknown function (DUF3124); Region: DUF3124; pfam11322
335659015407	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
335659015408	Aminotransferase class I and II; Region: Aminotran_1_2; pfam00155
335659015409	pyridoxal 5'-phosphate binding site [chemical binding]; other site
335659015410	homodimer interface [polypeptide binding]; other site
335659015411	catalytic residue [active]
335659015412	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
335659015413	non-specific DNA binding site [nucleotide binding]; other site
335659015414	salt bridge; other site
335659015415	sequence-specific DNA binding site [nucleotide binding]; other site
335659015416	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
335659015417	Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248
335659015418	active site
335659015419	catalytic tetrad [active]
335659015420	Phosphodiesterase/alkaline phosphatase D [Inorganic ion transport and metabolism]; Region: PhoD; COG3540
335659015421	Bacillus subtilis PhoD and related proteins, metallophosphatase domain; Region: MPP_PhoD; cd07389
335659015422	putative active site [active]
335659015423	putative metal binding site [ion binding]; other site
335659015424	Dioxygenases related to 2-nitropropane dioxygenase [General function prediction only]; Region: COG2070
335659015425	2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730
335659015426	FMN binding site [chemical binding]; other site
335659015427	substrate binding site [chemical binding]; other site
335659015428	putative catalytic residue [active]
335659015429	Short-chain alcohol dehydrogenase of unknown specificity [General function prediction only]; Region: COG4221
335659015430	classical (c) SDR, subgroup  10; Region: SDR_c10; cd05373
335659015431	putative NAD(P) binding site [chemical binding]; other site
335659015432	active site
335659015433	Predicted transcriptional regulators [Transcription]; Region: COG1733
335659015434	HxlR-like helix-turn-helix; Region: HxlR; pfam01638
335659015435	drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711
335659015436	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
335659015437	putative substrate translocation pore; other site
335659015438	Multidrug resistance efflux pump [Defense mechanisms]; Region: EmrA; COG1566
335659015439	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
335659015440	HlyD family secretion protein; Region: HlyD_3; pfam13437
335659015441	Domain of unknown function (DUF4142); Region: DUF4142; pfam13628
335659015442	oxidoreductase; Provisional; Region: PRK06128
335659015443	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
335659015444	NAD(P) binding site [chemical binding]; other site
335659015445	active site
335659015446	PAP2_like_2 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which is specific to bacteria, lacks functional characterization and may act as a membrane-associated lipid phosphatase; Region: PAP2_like_2; cd03392
335659015447	active site
335659015448	Protein of unknown function (DUF3147); Region: DUF3147; pfam11345
335659015449	Domain of unknown function (DUF4142); Region: DUF4142; cl17876
335659015450	Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840
335659015451	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
335659015452	dimerization interface [polypeptide binding]; other site
335659015453	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
335659015454	dimerization interface [polypeptide binding]; other site
335659015455	Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840
335659015456	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
335659015457	dimerization interface [polypeptide binding]; other site
335659015458	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
335659015459	dimerization interface [polypeptide binding]; other site
335659015460	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
335659015461	dimerization interface [polypeptide binding]; other site
335659015462	Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840
335659015463	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
335659015464	dimerization interface [polypeptide binding]; other site
335659015465	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
335659015466	dimerization interface [polypeptide binding]; other site
335659015467	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
335659015468	dimerization interface [polypeptide binding]; other site
335659015469	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
335659015470	dimerization interface [polypeptide binding]; other site
335659015471	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
335659015472	dimerization interface [polypeptide binding]; other site
335659015473	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
335659015474	dimerization interface [polypeptide binding]; other site
335659015475	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
335659015476	GAF domain; Region: GAF; pfam01590
335659015477	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
335659015478	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
335659015479	dimer interface [polypeptide binding]; other site
335659015480	phosphorylation site [posttranslational modification]
335659015481	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
335659015482	ATP binding site [chemical binding]; other site
335659015483	Mg2+ binding site [ion binding]; other site
335659015484	G-X-G motif; other site
335659015485	Response regulator receiver domain; Region: Response_reg; pfam00072
335659015486	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
335659015487	active site
335659015488	phosphorylation site [posttranslational modification]
335659015489	intermolecular recognition site; other site
335659015490	dimerization interface [polypeptide binding]; other site
335659015491	Response regulator receiver domain; Region: Response_reg; pfam00072
335659015492	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
335659015493	active site
335659015494	phosphorylation site [posttranslational modification]
335659015495	intermolecular recognition site; other site
335659015496	dimerization interface [polypeptide binding]; other site
335659015497	FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784
335659015498	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
335659015499	active site
335659015500	phosphorylation site [posttranslational modification]
335659015501	intermolecular recognition site; other site
335659015502	dimerization interface [polypeptide binding]; other site
335659015503	Response regulator receiver domain; Region: Response_reg; pfam00072
335659015504	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
335659015505	active site
335659015506	phosphorylation site [posttranslational modification]
335659015507	intermolecular recognition site; other site
335659015508	dimerization interface [polypeptide binding]; other site
335659015509	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459
335659015510	putative active site [active]
335659015511	heme pocket [chemical binding]; other site
335659015512	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920
335659015513	HWE histidine kinase; Region: HWE_HK; pfam07536
335659015514	periplasmic serine protease, Do/DeqQ family; Region: degP_htrA_DO; TIGR02037
335659015515	Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365
335659015516	PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987
335659015517	protein binding site [polypeptide binding]; other site
335659015518	PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987
335659015519	protein binding site [polypeptide binding]; other site
335659015520	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
335659015521	Ligand Binding Site [chemical binding]; other site
335659015522	glutamate and aspartate transporter subunit; Provisional; Region: PRK10797
335659015523	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
335659015524	substrate binding pocket [chemical binding]; other site
335659015525	membrane-bound complex binding site; other site
335659015526	hinge residues; other site
335659015527	Transcriptional regulators [Transcription]; Region: GntR; COG1802
335659015528	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
335659015529	DNA-binding site [nucleotide binding]; DNA binding site
335659015530	FCD domain; Region: FCD; pfam07729
335659015531	Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665
335659015532	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
335659015533	PAS fold; Region: PAS_4; pfam08448
335659015534	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
335659015535	putative active site [active]
335659015536	heme pocket [chemical binding]; other site
335659015537	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
335659015538	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
335659015539	metal binding site [ion binding]; metal-binding site
335659015540	active site
335659015541	I-site; other site
335659015542	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
335659015543	Pentose-5-phosphate-3-epimerase [Carbohydrate transport and metabolism]; Region: Rpe; COG0036
335659015544	Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose...; Region: RPE; cd00429
335659015545	substrate binding site [chemical binding]; other site
335659015546	hexamer interface [polypeptide binding]; other site
335659015547	metal binding site [ion binding]; metal-binding site
335659015548	probable Rubsico expression protein CbbX; Region: cbbX_cfxQ; TIGR02880
335659015549	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
335659015550	Walker A motif; other site
335659015551	ATP binding site [chemical binding]; other site
335659015552	Walker B motif; other site
335659015553	arginine finger; other site
335659015554	Ribulose bisphosphate carboxylase/oxygenase (Rubisco), small subunit. Rubisco is a bifunctional enzyme catalyzes the initial steps of two opposing metabolic pathways: photosynthetic carbon fixation and the competing process of photorespiration. Rubisco...; Region: RuBisCO_small; cd03527
335659015555	multimerization interface [polypeptide binding]; other site
335659015556	ribulose bisophosphate carboxylase; Reviewed; Region: rbcL; PRK04208
335659015557	Ribulose bisphosphate carboxylase large chain, Form I; Region: RuBisCO_large_I; cd08212
335659015558	homodimer interface [polypeptide binding]; other site
335659015559	active site
335659015560	heterodimer interface [polypeptide binding]; other site
335659015561	catalytic residue [active]
335659015562	metal binding site [ion binding]; metal-binding site
335659015563	fructose-bisphosphate aldolase; Provisional; Region: PRK09197
335659015564	Tagatose-1,6-bisphosphate (TBP) aldolase and related Type B Class II aldolases. TBP aldolase is a tetrameric class II aldolase that catalyzes the reversible condensation of dihydroxyacetone phosphate with glyceraldehyde 3-phsophate to produce tagatose 1; Region: TBP_aldolase_IIB; cd00947
335659015565	intersubunit interface [polypeptide binding]; other site
335659015566	active site
335659015567	zinc binding site [ion binding]; other site
335659015568	Na+ binding site [ion binding]; other site
335659015569	Transketolase [Carbohydrate transport and metabolism]; Region: TktA; COG0021
335659015570	Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012
335659015571	TPP-binding site [chemical binding]; other site
335659015572	dimer interface [polypeptide binding]; other site
335659015573	Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033
335659015574	PYR/PP interface [polypeptide binding]; other site
335659015575	dimer interface [polypeptide binding]; other site
335659015576	TPP binding site [chemical binding]; other site
335659015577	Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780
335659015578	phosphoribulokinase; Provisional; Region: PRK15453
335659015579	Fructose-1,6-bisphosphatase, an enzyme that catalyzes the hydrolysis of fructose-1,6-biphosphate  into fructose-6-phosphate and is critical in gluconeogenesis pathway. The alignment model also includes chloroplastic FBPases and sedoheptulose-1; Region: FBPase; cd00354
335659015580	metal binding site [ion binding]; metal-binding site
335659015581	active site
335659015582	Transcriptional regulator [Transcription]; Region: LysR; COG0583
335659015583	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
335659015584	The C-terminal substrate binding of LysR-type transcriptional regulator (CbbR) of RubisCO operon, which is involved in the carbon dioxide fixation, contains the type 2 periplasmic binding fold; Region: PBP2_CbbR_RubisCO_like; cd08419
335659015585	putative dimerization interface [polypeptide binding]; other site
335659015586	Methyltransferase domain; Region: Methyltransf_23; pfam13489
335659015587	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173
335659015588	C-methyltransferase C-terminal domain; Region: Methyltransf_14; pfam08484
335659015589	Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814
335659015590	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
335659015591	putative substrate translocation pore; other site
335659015592	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
335659015593	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
335659015594	N-carbamyl-D-amino acid amidohydrolase (DCase, class 6 nitrilases); Region: DCase; cd07569
335659015595	Predicted amidohydrolase [General function prediction only]; Region: COG0388
335659015596	tetramer interface [polypeptide binding]; other site
335659015597	active site
335659015598	catalytic triad [active]
335659015599	dimer interface [polypeptide binding]; other site
335659015600	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3181
335659015601	Putative translation factor (SUA5) [Translation, ribosomal structure and biogenesis]; Region: SUA5; COG0009
335659015602	Putative GTP-binding controlling metal-binding; Region: SUA5; pfam03481
335659015603	FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277
335659015604	FAD binding domain; Region: FAD_binding_4; pfam01565
335659015605	putative acetyltransferase; Provisional; Region: PRK03624
335659015606	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
335659015607	Coenzyme A binding pocket [chemical binding]; other site
335659015608	GDP-mannose pyrophosphatase NudK; Provisional; Region: PRK15009
335659015609	ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424
335659015610	dimer interface [polypeptide binding]; other site
335659015611	ADP-ribose binding site [chemical binding]; other site
335659015612	active site
335659015613	nudix motif; other site
335659015614	metal binding site [ion binding]; metal-binding site
335659015615	Opacity protein and related surface antigens [Cell envelope biogenesis, outer membrane]; Region: COG3637
335659015616	glycine reductase, selenoprotein B; Region: gly_red_sel_B; TIGR01917
335659015617	Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804
335659015618	CoA-transferase family III; Region: CoA_transf_3; pfam02515
335659015619	Uncharacterized ACR, COG2135; Region: DUF159; pfam02586
335659015620	Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_15; cd04673
335659015621	nudix motif; other site
335659015622	TIGR02301 family protein; Region: TIGR02301
335659015623	Rhodanese-related sulfurtransferase [Inorganic ion transport and metabolism]; Region: SseA; COG2897
335659015624	Thiosulfate sulfurtransferase (TST), N-terminal, inactive domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the 1st repeat, which does not contain the catalytically active Cys residue. The role of the 1st repeat is uncertain, but it...; Region: TST_Repeat_1; cd01448
335659015625	active site residue [active]
335659015626	Thiosulfate sulfurtransferase (TST), C-terminal, catalytic domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the second repeat. Only the second repeat contains the catalytically active Cys residue; Region: TST_Repeat_2; cd01449
335659015627	active site residue [active]
335659015628	dihydroorotase; Validated; Region: PRK09060
335659015629	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
335659015630	Dihydroorotase (DHOase), subgroup IIb; DHOases catalyze the reversible interconversion of carbamoyl aspartate to dihydroorotate, a key reaction in pyrimidine biosynthesis. This group contains the archeal members of the DHOase family; Region: DHOase_IIb; cd01318
335659015631	active site
335659015632	Aminomethyltransferase folate-binding domain; Region: GCV_T; pfam01571
335659015633	folate-binding protein YgfZ; Region: ygfZ_signature; TIGR03317
335659015634	Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669
335659015635	Methyladenine glycosylase; Region: Adenine_glyco; pfam03352
335659015636	HD domain; Region: HD_3; cl17350
335659015637	Predicted protein tyrosine phosphatase [General function prediction only]; Region: COG5350
335659015638	Uncharacterized conserved protein [General function prediction only]; Region: COG4111
335659015639	Predicted membrane protein (DUF2339); Region: DUF2339; pfam10101
335659015640	Four helix bundle sensory module for signal transduction; Region: 4HB_MCP_1; pfam12729
335659015641	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
335659015642	dimer interface [polypeptide binding]; other site
335659015643	putative CheW interface [polypeptide binding]; other site
335659015644	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
335659015645	dimerization interface [polypeptide binding]; other site
335659015646	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
335659015647	dimer interface [polypeptide binding]; other site
335659015648	putative CheW interface [polypeptide binding]; other site
335659015649	Yhdh putative quinone oxidoreductases; Region: MDR_yhdh; cd08288
335659015650	putative quinone oxidoreductase, YhdH/YhfP family; Region: oxido_YhdH; TIGR02823
335659015651	NADP binding site [chemical binding]; other site
335659015652	dimer interface [polypeptide binding]; other site
335659015653	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
335659015654	Major Facilitator Superfamily; Region: MFS_1; pfam07690
335659015655	putative substrate translocation pore; other site
335659015656	quinolinate synthetase; Provisional; Region: PRK09375
335659015657	L-aspartate oxidase; Provisional; Region: PRK07512
335659015658	L-aspartate oxidase; Provisional; Region: PRK06175
335659015659	Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910
335659015660	Nicotinate-nucleotide pyrophosphorylase [Coenzyme metabolism]; Region: NadC; COG0157
335659015661	Quinolinate phosphoribosyl transferase (QAPRTase or QPRTase), also called nicotinate-nucleotide pyrophosphorylase, is involved in the de novo synthesis of NAD in both prokaryotes and eukaryotes. It catalyses the reaction of quinolinic acid (QA) with...; Region: QPRTase; cd01572
335659015662	dimerization interface [polypeptide binding]; other site
335659015663	active site
335659015664	Cell wall hydrolyses involved in spore germination [Cell envelope biogenesis, outer membrane]; Region: SleB; COG3773
335659015665	Cell Wall Hydrolase; Region: Hydrolase_2; pfam07486
335659015666	pyruvate phosphate dikinase; Provisional; Region: PRK09279
335659015667	Pyruvate phosphate dikinase, PEP/pyruvate binding domain; Region: PPDK_N; pfam01326
335659015668	PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391
335659015669	PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896
335659015670	Protein of unknown function (DUF1236); Region: DUF1236; pfam06823
335659015671	glycyl-tRNA synthetase subunit beta; Validated; Region: glyS; PRK01233
335659015672	DALR anticodon binding domain; Region: DALR_1; pfam05746
335659015673	Class II Glycyl-tRNA synthetase (GlyRS) alpha subunit core catalytic domain. GlyRS functions as a homodimer in eukaryotes, archaea and some bacteria and as a heterotetramer in the remainder of prokaryotes and in arabidopsis. It is responsible for the...; Region: GlyRS_alpha_core; cd00733
335659015674	dimer interface [polypeptide binding]; other site
335659015675	motif 1; other site
335659015676	active site
335659015677	motif 2; other site
335659015678	motif 3; other site
335659015679	Signal peptide peptidase A (SppA), a serine protease, has catalytic Ser-Lys dyad; Region: S49_Sppa_N_C; cd07023
335659015680	signal peptide peptidase SppA, 36K type; Region: SppA_dom; TIGR00706
335659015681	tandem repeat interface [polypeptide binding]; other site
335659015682	oligomer interface [polypeptide binding]; other site
335659015683	active site residues [active]
335659015684	Predicted O-methyltransferase [General function prediction only]; Region: COG4123
335659015685	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173
335659015686	Domain of unknown function (DUF2007); Region: DUF2007; pfam09413
335659015687	Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142
335659015688	Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685
335659015689	substrate binding pocket [chemical binding]; other site
335659015690	chain length determination region; other site
335659015691	substrate-Mg2+ binding site; other site
335659015692	catalytic residues [active]
335659015693	aspartate-rich region 1; other site
335659015694	active site lid residues [active]
335659015695	aspartate-rich region 2; other site
335659015696	Predicted transcriptional regulators [Transcription]; Region: COG1733
335659015697	HxlR-like helix-turn-helix; Region: HxlR; pfam01638
335659015698	3-oxoacyl-(acyl carrier protein) synthase II; Reviewed; Region: PRK06333
335659015699	Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834
335659015700	dimer interface [polypeptide binding]; other site
335659015701	active site
335659015702	Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596
335659015703	Putative lysophospholipase; Region: Hydrolase_4; pfam12146
335659015704	4-diphosphocytidyl-2-C-methyl-D-erythritol kinase; Provisional; Region: PRK14608
335659015705	GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544
335659015706	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429
335659015707	TPR motif; other site
335659015708	binding surface
335659015709	TPR repeat; Region: TPR_11; pfam13414
335659015710	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
335659015711	binding surface
335659015712	TPR motif; other site
335659015713	TPR repeat; Region: TPR_11; pfam13414
335659015714	Dehydrogenases (flavoproteins) [Energy production and conversion]; Region: FixC; COG0644
335659015715	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
335659015716	Electron transfer flavoprotein-ubiquinone oxidoreductase; Region: ETF_QO; pfam05187
335659015717	Family 4 Uracil-DNA glycosylase (UDG), found exclusively in thermophilic organisms; Region: UDG_F4_TTUDGA_like; cd10030
335659015718	Fe-S cluster binding site [ion binding]; other site
335659015719	active site
335659015720	Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; cl17364
335659015721	bacterial Ribonuclease HII-like; Region: RNase_HII_bacteria_HII_like; cd07182
335659015722	RNA/DNA hybrid binding site [nucleotide binding]; other site
335659015723	active site
335659015724	This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_10; cd07251
335659015725	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
335659015726	DNA repair photolyase [DNA replication, recombination, and repair]; Region: SplB; COG1533
335659015727	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
335659015728	FeS/SAM binding site; other site
335659015729	putative phosphoketolase; Provisional; Region: PRK05261
335659015730	Thiamine pyrophosphate (TPP) family, Phosphoketolase (PK) subfamily, TPP-binding module; PK catalyzes the conversion of D-xylulose 5-phosphate and phosphate to acetyl phosphate, D-glyceraldehyde-3-phosphate and H2O. This enzyme requires divalent...; Region: TPP_PK; cd02011
335659015731	TPP-binding site; other site
335659015732	XFP C-terminal domain; Region: XFP_C; pfam09363
335659015733	propionate/acetate kinase; Provisional; Region: PRK12379
335659015734	Acetokinase family; Region: Acetate_kinase; cl17229
335659015735	Pyruvate phosphate dikinase, PEP/pyruvate binding domain; Region: PPDK_N; pfam01326
335659015736	PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391
335659015737	Uncharacterized ACR, YagE family COG1723; Region: DUF155; pfam02582
335659015738	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
335659015739	active site
335659015740	Transcriptional regulators [Transcription]; Region: MarR; COG1846
335659015741	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
335659015742	dimerization interface [polypeptide binding]; other site
335659015743	putative Zn2+ binding site [ion binding]; other site
335659015744	putative DNA binding site [nucleotide binding]; other site
335659015745	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
335659015746	Coenzyme A binding pocket [chemical binding]; other site
335659015747	MogA_MoaB family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF) an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea; Region: MogA_MoaB; cd00886
335659015748	MPT binding site; other site
335659015749	trimer interface [polypeptide binding]; other site
335659015750	Predicted metalloprotease [General function prediction only]; Region: COG2321
335659015751	Putative neutral zinc metallopeptidase; Region: Zn_peptidase; pfam04228
335659015752	DNA modification methylase [DNA replication, recombination, and repair]; Region: COG0863
335659015753	DNA methylase; Region: N6_N4_Mtase; pfam01555
335659015754	Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625
335659015755	GST_N family, Ure2p-like subfamily; composed of the Saccharomyces cerevisiae Ure2p and related GSTs. Ure2p is a regulator for nitrogen catabolism in yeast. It represses the expression of several gene products involved in the use of poor nitrogen sources...; Region: GST_N_Ure2p_like; cd03048
335659015756	C-terminal domain interface [polypeptide binding]; other site
335659015757	GSH binding site (G-site) [chemical binding]; other site
335659015758	dimer interface [polypeptide binding]; other site
335659015759	C-terminal, alpha helical domain of the Glutathione S-transferase family; Region: GST_C_family; cl02776
335659015760	N-terminal domain interface [polypeptide binding]; other site
335659015761	dimer interface [polypeptide binding]; other site
335659015762	substrate binding pocket (H-site) [chemical binding]; other site
335659015763	HAMP domain; Region: HAMP; pfam00672
335659015764	dimerization interface [polypeptide binding]; other site
335659015765	Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283
335659015766	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
335659015767	dimer interface [polypeptide binding]; other site
335659015768	putative CheW interface [polypeptide binding]; other site
335659015769	Bacteriophytochrome (light-regulated signal transduction histidine kinase) [Signal transduction mechanisms]; Region: COG4251
335659015770	GAF domain; Region: GAF; pfam01590
335659015771	Phytochrome region; Region: PHY; pfam00360
335659015772	HWE histidine kinase; Region: HWE_HK; smart00911
335659015773	FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784
335659015774	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
335659015775	active site
335659015776	phosphorylation site [posttranslational modification]
335659015777	intermolecular recognition site; other site
335659015778	dimerization interface [polypeptide binding]; other site
335659015779	Heme oxygenase catalyzes the rate limiting step in the degradation of heme to bilirubin, it is essential for recycling of iron from heme. Heme is used as a substrate and cofactor for its own degradation to biliverdin, iron, and carbon monoxide. This...; Region: HemeO; cl17299
335659015780	heme binding pocket [chemical binding]; other site
335659015781	heme ligand [chemical binding]; other site
335659015782	Ketosteroid isomerase-related protein [General function prediction only]; Region: COG3631
335659015783	Transcriptional regulator [Transcription]; Region: LysR; COG0583
335659015784	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
335659015785	The C-terminal substrate binding domain of LysR-type transcriptional regulators that involved in the catabolism of nitroaromatic/naphthalene compounds and that of related regulators; contains the type 2 periplasmic binding fold; Region: PBP2_Nitroaromatics_like; cd08417
335659015786	substrate binding pocket [chemical binding]; other site
335659015787	dimerization interface [polypeptide binding]; other site
335659015788	Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625
335659015789	GST_N family, Class Beta subfamily; GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of endogenous and xenobiotic alkylating agents, including carcinogens; Region: GST_N_Beta; cd03057
335659015790	C-terminal domain interface [polypeptide binding]; other site
335659015791	GSH binding site (G-site) [chemical binding]; other site
335659015792	dimer interface [polypeptide binding]; other site
335659015793	C-terminal, alpha helical domain of Class Beta Glutathione S-transferases; Region: GST_C_Beta; cd03188
335659015794	dimer interface [polypeptide binding]; other site
335659015795	N-terminal domain interface [polypeptide binding]; other site
335659015796	substrate binding pocket (H-site) [chemical binding]; other site
335659015797	hypothetical protein; Provisional; Region: PRK07538
335659015798	hypothetical protein; Provisional; Region: PRK07236
335659015799	PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria.  Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443
335659015800	CoenzymeA binding site [chemical binding]; other site
335659015801	subunit interaction site [polypeptide binding]; other site
335659015802	PHB binding site; other site
335659015803	Thioesterase-like superfamily; Region: 4HBT_3; pfam13622
335659015804	Cache domain; Region: Cache_1; pfam02743
335659015805	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
335659015806	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
335659015807	metal binding site [ion binding]; metal-binding site
335659015808	active site
335659015809	I-site; other site
335659015810	A/G-specific DNA glycosylase [DNA replication, recombination, and repair]; Region: MutY; COG1194
335659015811	endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056
335659015812	minor groove reading motif; other site
335659015813	helix-hairpin-helix signature motif; other site
335659015814	substrate binding pocket [chemical binding]; other site
335659015815	active site
335659015816	Iron-sulfur binding domain of endonuclease III; Region: EndIII_4Fe-2S; pfam10576
335659015817	DNA glycosylase (MutY in bacteria and hMYH in humans) is responsible for repairing misread  A*oxoG residues to C*G by removing the inappropriately paired adenine base from the DNA backbone. It belongs to the Nudix hydrolase superfamily and is important...; Region: DNA_Glycosylase_C; cd03431
335659015818	DNA binding and oxoG recognition site [nucleotide binding]
335659015819	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl17200
335659015820	Protein of unknown function (DUF721); Region: DUF721; cl02324
335659015821	Thioredoxin; Region: Thioredoxin_4; pfam13462
335659015822	DSBA-like thioredoxin domain; Region: DSBA; pfam01323
335659015823	ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278
335659015824	AAA domain; Region: AAA_23; pfam13476
335659015825	Walker A/P-loop; other site
335659015826	ATP binding site [chemical binding]; other site
335659015827	Chromosome segregation ATPases [Cell division and chromosome partitioning]; Region: Smc; COG1196
335659015828	ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278
335659015829	ABC transporter signature motif; other site
335659015830	Walker B; other site
335659015831	D-loop; other site
335659015832	H-loop/switch region; other site
335659015833	Mitochondrial small ribosomal subunit Rsm22; Region: Rsm22; cl17847
335659015834	Uncharacterized conserved protein [Function unknown]; Region: LemA; COG1704
335659015835	Peptidase family M48; Region: Peptidase_M48; cl12018
335659015836	Peptidase family M48; Region: Peptidase_M48; cl12018
335659015837	GIY-YIG domain of LuxR and ArsR family transcriptional regulators, and uncharacterized hypothetical proteins found in bacteria; Region: GIY-YIG_LuxR_like; cd10451
335659015838	GIY-YIG motif/motif A; other site
335659015839	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
335659015840	active site
335659015841	anthranilate synthase; Provisional; Region: PRK13566
335659015842	Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715
335659015843	chorismate binding enzyme; Region: Chorismate_bind; pfam00425
335659015844	Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743
335659015845	glutamine binding [chemical binding]; other site
335659015846	catalytic triad [active]
335659015847	Dienelactone hydrolase and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG0412
335659015848	cytochrome b; Provisional; Region: CYTB; MTH00145
335659015849	Cytochrome b (N-terminus)/b6/petB:  Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria; Region: Cytochrome_b_N; cd00284
335659015850	Qi binding site; other site
335659015851	intrachain domain interface; other site
335659015852	interchain domain interface [polypeptide binding]; other site
335659015853	heme bH binding site [chemical binding]; other site
335659015854	heme bL binding site [chemical binding]; other site
335659015855	Qo binding site; other site
335659015856	Cytochrome b(C-terminus)/b6/petD:  Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria; Region: cytochrome_b_C; cd00290
335659015857	interchain domain interface [polypeptide binding]; other site
335659015858	intrachain domain interface; other site
335659015859	Qi binding site; other site
335659015860	Qo binding site; other site
335659015861	Cytochrome C1 family; Region: Cytochrom_C1; pfam02167
335659015862	ubiquinol-cytochrome c reductase, iron-sulfur subunit; Region: Rieske_proteo; TIGR01416
335659015863	Iron-sulfur protein (ISP) component of the bc(1) complex family, Rieske domain; The Rieske domain is a [2Fe-2S] cluster binding domain involved in electron transfer. The bc(1) complex is a multisubunit enzyme found in many different organisms including...; Region: Rieske_cytochrome_bc1; cd03470
335659015864	[2Fe-2S] cluster binding site [ion binding]; other site
335659015865	Predicted rRNA methylase (SpoU class) [Translation, ribosomal structure and biogenesis]; Region: CspR; COG0219
335659015866	Organic radical activating enzymes [Posttranslational modification, protein turnover, chaperones]; Region: NrdG; COG0602
335659015867	putative 7-cyano-7-deazaguanosine (preQ0) biosynthesis protein QueE; Region: rSAM_QueE_Ecoli; TIGR04322
335659015868	6-pyruvoyl tetrahydropterin synthase; Region: PTPS; pfam01242
335659015869	active site
335659015870	coproporphyrinogen III oxidase; Provisional; Region: PRK05330
335659015871	Coproporphyrinogen III oxidase; Region: Coprogen_oxidas; cl17752
335659015872	Predicted hydrolase (HAD superfamily) [General function prediction only]; Region: COG1011
335659015873	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
335659015874	motif II; other site
335659015875	Uncharacterized small protein (DUF2158); Region: DUF2158; cl02293
335659015876	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
335659015877	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
335659015878	DNA binding residues [nucleotide binding]
335659015879	dimerization interface [polypeptide binding]; other site
335659015880	glucan biosynthesis protein G; Provisional; Region: mdoG; PRK13274
335659015881	glucan biosynthesis protein D; Provisional; Region: mdoD; PRK13273
335659015882	Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641
335659015883	Glucan_BSP_ModH catalyzes the elongation of beta-1,2 polyglucose chains of glucan; Region: Glucan_BSP_ModH; cd04191
335659015884	Ligand binding site; other site
335659015885	DXD motif; other site
335659015886	lipoprotein releasing system, transmembrane protein, LolC/E family; Region: lolCE; TIGR02212
335659015887	MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
335659015888	FtsX-like permease family; Region: FtsX; pfam02687
335659015889	PIN (PilT N terminus) domain: Superfamily; Region: PIN_SF; cl14812
335659015890	putative active site [active]
335659015891	Tripartite tricarboxylate transporter family receptor; Region: TctC; cl17792
335659015892	N-methylhydantoinase B/acetone carboxylase, alpha subunit [Amino acid transport and metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: HyuB; COG0146
335659015893	Hydantoinase B/oxoprolinase; Region: Hydantoinase_B; pfam02538
335659015894	N-methylhydantoinase A/acetone carboxylase, beta subunit [Amino acid transport and metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: HyuA; COG0145
335659015895	Hydantoinase/oxoprolinase N-terminal region; Region: Hydant_A_N; pfam05378
335659015896	Hydantoinase/oxoprolinase; Region: Hydantoinase_A; pfam01968
335659015897	D-amino acid dehydrogenase small subunit; Validated; Region: PRK00711
335659015898	Ketopantoate reductase PanE/ApbA; Region: ApbA; pfam02558
335659015899	Transcriptional regulator [Transcription]; Region: LysR; COG0583
335659015900	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
335659015901	TThe C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator, contains the type 2 periplasmic binding fold; Region: PBP2_LTTR_like_4; cd08440
335659015902	putative dimerization interface [polypeptide binding]; other site
335659015903	Cytochrome c; Region: Cytochrom_C; pfam00034
335659015904	Cytochrome c; Region: Cytochrom_C; cl11414
335659015905	Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340
335659015906	Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586
335659015907	Antibiotic biosynthesis monooxygenase; Region: ABM; pfam03992
335659015908	tRNA nucleotidyltransferase/poly(A) polymerase [Translation, ribosomal structure and biogenesis]; Region: PcnB; COG0617
335659015909	Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398
335659015910	active site
335659015911	NTP binding site [chemical binding]; other site
335659015912	metal binding triad [ion binding]; metal-binding site
335659015913	Coenzyme A pyrophosphatase (CoAse), a member of the Nudix hydrolase superfamily, functions to catalyze the elimination of oxidized inactive CoA, which can inhibit CoA-utilizing enzymes. The need of CoAses mainly arises under conditions of oxidative...; Region: CoAse; cd03426
335659015914	putative active site [active]
335659015915	putative CoA binding site [chemical binding]; other site
335659015916	nudix motif; other site
335659015917	metal binding site [ion binding]; metal-binding site
335659015918	Protein of unknown function (DUF1285); Region: DUF1285; pfam06938
335659015919	MoxR-like ATPases [General function prediction only]; Region: COG0714
335659015920	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
335659015921	Walker A motif; other site
335659015922	ATP binding site [chemical binding]; other site
335659015923	Walker B motif; other site
335659015924	arginine finger; other site
335659015925	Uncharacterized conserved protein (some members contain a von Willebrand factor type A (vWA) domain) [General function prediction only]; Region: COG1721
335659015926	Protein of unknown function DUF58; Region: DUF58; pfam01882
335659015927	Aerotolerance regulator N-terminal; Region: BatA; cl06567
335659015928	A4 beta-galactosidase middle domain: a type 1 glutamine amidotransferase (GATase1)-like domain; Region: A4_beta-galactosidase_middle_domain; cd03143
335659015929	Domain of unknown function (DUF4159); Region: DUF4159; pfam13709
335659015930	Protein of unknown function (DUF1355); Region: DUF1355; cl17712
335659015931	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244
335659015932	Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629
335659015933	YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448
335659015934	homotrimer interaction site [polypeptide binding]; other site
335659015935	putative active site [active]
335659015936	YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448
335659015937	homotrimer interaction site [polypeptide binding]; other site
335659015938	putative active site [active]
335659015939	YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448
335659015940	homotrimer interaction site [polypeptide binding]; other site
335659015941	putative active site [active]
335659015942	3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557
335659015943	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
335659015944	NAD(P) binding site [chemical binding]; other site
335659015945	active site
335659015946	Transcriptional regulator [Transcription]; Region: LysR; COG0583
335659015947	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
335659015948	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
335659015949	dimerization interface [polypeptide binding]; other site
335659015950	Protein of unknown function (DUF3830); Region: DUF3830; pfam12903
335659015951	ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747
335659015952	The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_8; cd08495
335659015953	Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673
335659015954	Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583
335659015955	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
335659015956	Coenzyme A binding pocket [chemical binding]; other site
335659015957	dolichyl-phosphate beta-D-mannosyltransferase; Region: PLN02726
335659015958	DPM_DPG-synthase_like is a member of the Glycosyltransferase 2 superfamily; Region: DPM_DPG-synthase_like; cd04179
335659015959	Ligand binding site; other site
335659015960	Putative Catalytic site; other site
335659015961	DXD motif; other site
335659015962	Uncharacterized conserved protein (DUF2304); Region: DUF2304; cl01034
335659015963	Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_21; cd04680
335659015964	nudix motif; other site
335659015965	Bacillus subtilis YydB and related proteins, metallophosphatase domain; Region: MPP_YydB; cd07400
335659015966	putative active site [active]
335659015967	putative metal binding site [ion binding]; other site
335659015968	Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149
335659015969	metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995
335659015970	isocitrate lyase; Provisional; Region: PRK15063
335659015971	Members of the ICL/PEPM enzyme family catalyze either P-C or C-C bond formation/cleavage. Known members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate hydrolase (OAH), isocitrate...; Region: ICL_PEPM; cd00377
335659015972	tetramer interface [polypeptide binding]; other site
335659015973	active site
335659015974	Mg2+/Mn2+ binding site [ion binding]; other site
335659015975	isocitrate lyase; Region: PLN02892
335659015976	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
335659015977	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
335659015978	non-specific DNA binding site [nucleotide binding]; other site
335659015979	salt bridge; other site
335659015980	sequence-specific DNA binding site [nucleotide binding]; other site
335659015981	Predicted transcriptional regulator [General function prediction only]; Region: COG3800
335659015982	Domain of unknown function (DUF955); Region: DUF955; pfam06114
335659015983	Predicted transcriptional regulator (DUF2083); Region: DUF2083; pfam09856
335659015984	Phosphoenolpyruvate:glucose-phosphotransferase regulator; Region: MtfA; cl01267
335659015985	TPR repeat; Region: TPR_11; pfam13414
335659015986	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
335659015987	binding surface
335659015988	TPR motif; other site
335659015989	TPR repeat; Region: TPR_11; pfam13414
335659015990	heat shock protein HtpX; Provisional; Region: PRK01345
335659015991	lytic murein transglycosylase; Region: MltB_2; TIGR02283
335659015992	murein hydrolase B; Provisional; Region: PRK10760; cl17906
335659015993	Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471
335659015994	Domain of unknown function (DUF1993); Region: DUF1993; pfam09351
335659015995	NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902
335659015996	Old yellow enzyme (OYE)-like FMN binding domain. OYE was the first flavin-dependent enzyme identified, however its true physiological role remains elusive to this day. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a...; Region: OYE_like_FMN; cd02933
335659015997	FMN binding site [chemical binding]; other site
335659015998	active site
335659015999	substrate binding site [chemical binding]; other site
335659016000	catalytic residue [active]
335659016001	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653
335659016002	Predicted small integral membrane protein (DUF2160); Region: DUF2160; pfam09928
335659016003	ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395
335659016004	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
335659016005	dimer interface [polypeptide binding]; other site
335659016006	conserved gate region; other site
335659016007	putative PBP binding loops; other site
335659016008	ABC-ATPase subunit interface; other site
335659016009	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
335659016010	dimer interface [polypeptide binding]; other site
335659016011	conserved gate region; other site
335659016012	putative PBP binding loops; other site
335659016013	ABC-ATPase subunit interface; other site
335659016014	ABC-type sugar transport systems, ATPase components [Carbohydrate transport and metabolism]; Region: MalK; COG3839
335659016015	ATP-binding cassette domain of the carbohydrate and solute transporters-like; Region: ABC_Carb_Solutes_like; cd03259
335659016016	Walker A/P-loop; other site
335659016017	ATP binding site [chemical binding]; other site
335659016018	Q-loop/lid; other site
335659016019	ABC transporter signature motif; other site
335659016020	Walker B; other site
335659016021	D-loop; other site
335659016022	H-loop/switch region; other site
335659016023	ABC-type sugar transport systems, ATPase components [Carbohydrate transport and metabolism]; Region: MalK; COG3839
335659016024	ATP-binding cassette domain of the carbohydrate and solute transporters-like; Region: ABC_Carb_Solutes_like; cd03259
335659016025	Walker A/P-loop; other site
335659016026	ATP binding site [chemical binding]; other site
335659016027	Q-loop/lid; other site
335659016028	ABC transporter signature motif; other site
335659016029	Walker B; other site
335659016030	D-loop; other site
335659016031	H-loop/switch region; other site
335659016032	TOBE domain; Region: TOBE; pfam03459
335659016033	glycerol-3-phosphate dehydrogenase; Reviewed; Region: glpD; PRK12266
335659016034	Antitoxin Phd_YefM, type II toxin-antitoxin system; Region: PhdYeFM_antitox; pfam02604
335659016035	PIN domain of ribonucleases (toxins), VapC and FitB, of prokaryotic toxin/antitoxin operons, Pyrococcus horikoshii protein PH0500, and other similar bacterial and archaeal homologs; Region: PIN_VapC-FitB; cd09881
335659016036	oligomeric interface; other site
335659016037	putative active site [active]
335659016038	homodimer interface [polypeptide binding]; other site
335659016039	Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349
335659016040	DeoR-like helix-turn-helix domain; Region: HTH_DeoR; pfam08220
335659016041	DeoR C terminal sensor domain; Region: DeoRC; pfam00455
335659016042	beta-phosphoglucomutase family hydrolase; Region: PGMB-YQAB-SF; TIGR02009
335659016043	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
335659016044	active site
335659016045	motif I; other site
335659016046	motif II; other site
335659016047	Brown fat-inducible thioesterase (BFIT).  Brain acyl-CoA hydrolase (BACH).  These enzymes deacylate long-chain fatty acids by hydrolyzing acyl-CoA thioesters to free fatty acids and CoA-SH. Eukaryotic members of this family are expressed in brain, testis; Region: BFIT_BACH; cd03442
335659016048	multifunctional fatty acid oxidation complex subunit alpha; Reviewed; Region: fadJ; PRK11154
335659016049	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
335659016050	substrate binding site [chemical binding]; other site
335659016051	oxyanion hole (OAH) forming residues; other site
335659016052	trimer interface [polypeptide binding]; other site
335659016053	3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737
335659016054	3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725
335659016055	acetyl-CoA acetyltransferase; Provisional; Region: PRK08170
335659016056	Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751
335659016057	dimer interface [polypeptide binding]; other site
335659016058	active site
335659016059	acyl-CoA dehydrogenase; Reviewed; Region: fadE; PRK09463
335659016060	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
335659016061	active site
335659016062	Domain of unknown function (DUF1974); Region: DUF1974; pfam09317
335659016063	Conserved protein/domain typically associated with flavoprotein oxygenases, DIM6/NTAB family [General function prediction only]; Region: COG1853
335659016064	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
335659016065	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
335659016066	Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841
335659016067	RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730
335659016068	Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849
335659016069	HlyD family secretion protein; Region: HlyD_3; pfam13437
335659016070	4-hydroxyphenylacetate permease; Region: HpaX; TIGR02332
335659016071	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
335659016072	putative substrate translocation pore; other site
335659016073	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3214
335659016074	Protein of unknown function (DUF1006); Region: DUF1006; pfam06224
335659016075	Uncharacterized protein containing caspase domain [General function prediction only]; Region: COG4249
335659016076	Caspase domain; Region: Peptidase_C14; pfam00656
335659016077	Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471
335659016078	Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885
335659016079	Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185
335659016080	ligand binding site [chemical binding]; other site
335659016081	Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; cl17364
335659016082	FecR protein; Region: FecR; pfam04773
335659016083	Escherichia coli PhnB and similar proteins; the E. coli phnB gene is found next to an operon involved in the cleavage of carbon-phosphorus bonds in unactivated alkylphosphonates; Region: PhnB_like; cd06588
335659016084	dimer interface [polypeptide binding]; other site
335659016085	This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_24; cd09012
335659016086	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
335659016087	Cupin domain; Region: Cupin_2; cl17218
335659016088	CsbD-like; Region: CsbD; cl17424
335659016089	FKBP-type peptidyl-prolyl cis-trans isomerases 1 [Posttranslational modification, protein turnover, chaperones]; Region: FkpA; COG0545
335659016090	FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254
335659016091	Gamma-glutamyltransferase [Amino acid transport and metabolism]; Region: Ggt; COG0405
335659016092	Gamma-glutamyltranspeptidase; Region: G_glu_transpept; pfam01019
335659016093	rhodanese superfamily protein; Provisional; Region: PRK05320
335659016094	Member of the Rhodanese Homology Domain superfamily. This CD includes Escherichia coli YceA, Bacillus subtilis YbfQ, and similar uncharacterized proteins; Region: RHOD_YceA; cd01518
335659016095	active site residue [active]
335659016096	SlyX; Region: SlyX; pfam04102
335659016097	Cache domain; Region: Cache_1; pfam02743
335659016098	PAS domain S-box; Region: sensory_box; TIGR00229
335659016099	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
335659016100	putative active site [active]
335659016101	heme pocket [chemical binding]; other site
335659016102	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
335659016103	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
335659016104	metal binding site [ion binding]; metal-binding site
335659016105	active site
335659016106	I-site; other site
335659016107	methylcobalamin:coenzyme M methyltransferase; Validated; Region: PRK06252
335659016108	Uroporphyrinogen decarboxylase (URO-D) is a dimeric cytosolic enzyme that decarboxylates the four acetate side chains of uroporphyrinogen III (uro-III) to create coproporphyrinogen III, without requiring any prosthetic groups or cofactors. This reaction...; Region: URO-D; cd00717
335659016109	substrate binding site [chemical binding]; other site
335659016110	active site
335659016111	Response regulator [Signal transduction mechanisms]; Region: TtrR; COG4566
335659016112	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
335659016113	active site
335659016114	phosphorylation site [posttranslational modification]
335659016115	intermolecular recognition site; other site
335659016116	dimerization interface [polypeptide binding]; other site
335659016117	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
335659016118	DNA binding residues [nucleotide binding]
335659016119	dimerization interface [polypeptide binding]; other site
335659016120	Porphobilinogen deaminase [Coenzyme metabolism]; Region: HemC; COG0181
335659016121	Hydroxymethylbilane synthase (HMBS), also known as porphobilinogen deaminase (PBGD), is an intermediate enzyme in the biosynthetic pathway of tetrapyrrolic ring systems, such as heme, chlorophylls, and vitamin B12. HMBS catalyzes the conversion of...; Region: HMBS; cl17708
335659016122	domain interfaces; other site
335659016123	active site
335659016124	choline dehydrogenase; Validated; Region: PRK02106
335659016125	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
335659016126	GMC oxidoreductase; Region: GMC_oxred_C; pfam05199
335659016127	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
335659016128	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
335659016129	SnoaL-like domain; Region: SnoaL_2; pfam12680
335659016130	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
335659016131	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
335659016132	metal binding site [ion binding]; metal-binding site
335659016133	active site
335659016134	I-site; other site
335659016135	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
335659016136	Flavodoxin reductases (ferredoxin-NADPH reductases) family 1 [Energy production and conversion]; Region: Hmp; COG1018
335659016137	Phthalate dioxygenase reductase (PDR) is an FMN-dependent reductase that mediates electron transfer from NADH to FMN to an iron sulfur cluster. PDR has an an N-terminal  ferrredoxin reductase (FNR)-like NAD(H) binding domain and a C-terminal iron-sulfur; Region: PDR_like; cd06185
335659016138	FMN-binding pocket [chemical binding]; other site
335659016139	flavin binding motif; other site
335659016140	phosphate binding motif [ion binding]; other site
335659016141	beta-alpha-beta structure motif; other site
335659016142	NAD binding pocket [chemical binding]; other site
335659016143	Ferredoxin [Energy production and conversion]; Region: Fdx; COG0633
335659016144	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
335659016145	catalytic loop [active]
335659016146	iron binding site [ion binding]; other site
335659016147	phosphonate utilization associated transcriptional regulator; Region: phnR_burk; TIGR03338
335659016148	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
335659016149	DNA-binding site [nucleotide binding]; DNA binding site
335659016150	This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895
335659016151	Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638
335659016152	Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cl00938
335659016153	iron-sulfur cluster [ion binding]; other site
335659016154	[2Fe-2S] cluster binding site [ion binding]; other site
335659016155	C-terminal catalytic domain of the oxygenase alpha subunit of dicamba O-demethylase and related aromatic ring hydroxylating dioxygenases; Region: RHO_alpha_C_DMO-like; cd08878
335659016156	alpha subunit interface [polypeptide binding]; other site
335659016157	active site
335659016158	substrate binding site [chemical binding]; other site
335659016159	Fe binding site [ion binding]; other site
335659016160	phosphoglucomutase; Validated; Region: PRK07564
335659016161	This bacterial PGM-like (phosphoglucomutase-like) protein of unknown function belongs to the alpha-D-phosphohexomutase superfamily. The alpha-D-phosphohexomutases include several related enzymes that catalyze a reversible intramolecular phosphoryl...; Region: PGM_like3; cd05801
335659016162	active site
335659016163	substrate binding site [chemical binding]; other site
335659016164	metal binding site [ion binding]; metal-binding site
335659016165	Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695
335659016166	DNA-binding transcriptional regulator TorR; Provisional; Region: PRK10766
335659016167	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
335659016168	active site
335659016169	phosphorylation site [posttranslational modification]
335659016170	intermolecular recognition site; other site
335659016171	dimerization interface [polypeptide binding]; other site
335659016172	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
335659016173	DNA binding site [nucleotide binding]
335659016174	Acyltransferase family; Region: Acyl_transf_3; pfam01757
335659016175	Aldose 1-epimerase, similar to Lactococcus lactis lacX; Region: Aldose_epim_lacX; cd09024
335659016176	active site
335659016177	catalytic residues [active]
335659016178	YqaJ-like viral recombinase domain; Region: YqaJ; pfam09588
335659016179	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
335659016180	non-specific DNA binding site [nucleotide binding]; other site
335659016181	salt bridge; other site
335659016182	sequence-specific DNA binding site [nucleotide binding]; other site
335659016183	Type I periplasmic ligand-binding domain of uncharacterized ABC (ATPase Binding Cassette)-type active transport systems that are predicted to be involved in uptake of amino acids, peptides, or inorganic ions; Region: PBP1_ABC_ligand_binding_like_8; cd06343
335659016184	Periplasmic binding protein; Region: Peripla_BP_6; pfam13458
335659016185	putative ligand binding site [chemical binding]; other site
335659016186	Uncharacterized conserved protein [Function unknown]; Region: COG1432
335659016187	LabA_like proteins; Region: LabA; cd10911
335659016188	putative metal binding site [ion binding]; other site
335659016189	Condensation domain; Region: Condensation; pfam00668
335659016190	Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020
335659016191	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
335659016192	acyl-activating enzyme (AAE) consensus motif; other site
335659016193	natural product biosynthesis luciferase-like monooxygenase domain; Region: seco_metab_LLM; TIGR04020
335659016194	Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892
335659016195	N5,N10-methylenetetrahydromethanopterin reductase (Mer) catalyzes the reduction of N5,N10-methylenetetrahydromethanopterin with reduced coenzyme F420 to N5-methyltetrahydromethanopterin and oxidized coenzyme F420; Region: Tetrahydromethanopterin_reductase; cd01097
335659016196	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
335659016197	active site
335659016198	CoA binding site [chemical binding]; other site
335659016199	AMP binding site [chemical binding]; other site
335659016200	Methyltransferase domain; Region: Methyltransf_31; pfam13847
335659016201	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
335659016202	S-adenosylmethionine binding site [chemical binding]; other site
335659016203	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
335659016204	Phosphopantetheine attachment site; Region: PP-binding; pfam00550
335659016205	Beta-ketoacyl synthase; Region: PKS_KS; smart00825
335659016206	polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833
335659016207	active site
335659016208	malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128
335659016209	Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827
335659016210	ketoreductase (KR), subgroup 2, complex (x) SDRs; Region: KR_2_SDR_x; cd08953
335659016211	This enzymatic domain is part of bacterial polyketide synthases; Region: PKS_KR; smart00822
335659016212	putative NADP binding site [chemical binding]; other site
335659016213	active site
335659016214	Dehydratase domain in polyketide synthase (PKS) enzymes; Region: PKS_DH; smart00826
335659016215	Phosphopantetheine attachment site; Region: PP-binding; pfam00550
335659016216	Thioesterase domains of type I polyketide synthases or non-ribosomal peptide synthetases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3319
335659016217	aldose 1-epimerase superfamily; Region: Aldose_epim; cl14648
335659016218	catalytic residues [active]
335659016219	Predicted UDP-glucose 6-dehydrogenase [Cell envelope biogenesis, outer membrane]; Region: Ugd; COG1004
335659016220	NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210
335659016221	UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984
335659016222	UDP binding domain; Region: UDPG_MGDP_dh_C; smart00984
335659016223	mannose-1-phosphate guanylyltransferase/mannose-6-phosphate isomerase; Region: GMP_PMI; TIGR01479
335659016224	GDP-M1P_Guanylyltransferase catalyzes the formation of GDP-Mannose; Region: GDP-M1P_Guanylyltransferase; cd02509
335659016225	Substrate binding site; other site
335659016226	Mannose-6-phosphate isomerase; Region: MannoseP_isomer; pfam01050
335659016227	Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451
335659016228	UDP glucuronic acid epimerase, extended (e) SDRs; Region: UDP_GE_SDE_e; cd05253
335659016229	putative NAD(P) binding site [chemical binding]; other site
335659016230	active site
335659016231	putative substrate binding site [chemical binding]; other site
335659016232	This family is most closely related to the GT1 family of glycosyltransferases. mtfB (mannosyltransferase B) in E. coli has been shown to direct the growth of the O9-specific polysaccharide chain. It transfers two mannoses into the position 3 of the...; Region: GT1_mtfB_like; cd03809
335659016233	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
335659016234	This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801
335659016235	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
335659016236	Periplasmic protein involved in polysaccharide export, contains    SLBB domain of b-grasp fold [Cell wall/membrane/envelope biogenesis]; Region: Wza; COG1596
335659016237	Polysaccharide biosynthesis/export protein; Region: Poly_export; pfam02563
335659016238	Glycosyl hydrolases family 17; Region: Glyco_hydro_17; pfam00332
335659016239	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
335659016240	This family is most closely related to the GT1 family of glycosyltransferases. ExpE7 in Sinorhizobium meliloti has been shown to be involved in the biosynthesis of galactoglucans (exopolysaccharide II); Region: GT1_ExpE7_like; cd03823
335659016241	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
335659016242	This family is most closely related to the GT1 family of glycosyltransferases. ExpE7 in Sinorhizobium meliloti has been shown to be involved in the biosynthesis of galactoglucans (exopolysaccharide II); Region: GT1_ExpE7_like; cd03823
335659016243	Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; Region: MATE_tuaB_like; cd13127
335659016244	Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463
335659016245	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761
335659016246	active site
335659016247	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
335659016248	This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801
335659016249	Predicted acyltransferases [Lipid metabolism]; Region: COG1835
335659016250	Predicted acyltransferases [Lipid metabolism]; Region: COG1835
335659016251	Predicted acyltransferases [Lipid metabolism]; Region: COG1835
335659016252	Predicted acyltransferases [Lipid metabolism]; Region: COG1835
335659016253	Predicted acyltransferases [Lipid metabolism]; Region: COG1835
335659016254	O-Antigen ligase; Region: Wzy_C; pfam04932
335659016255	Bacterial transglutaminase-like cysteine proteinase BTLCP; Region: BTLCP; cl17596
335659016256	Chain length determinant protein; Region: Wzz; pfam02706
335659016257	exopolysaccharide transport protein family; Region: eps_transp_fam; TIGR01005
335659016258	Chain length determinant protein; Region: Wzz; cl15801
335659016259	ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042
335659016260	Magnesium ion binding site [ion binding]; other site
335659016261	Undecaprenyl-phosphate glucose phosphotransferase; Region: WcaJ_sugtrans; TIGR03023
335659016262	Bacterial sugar transferase; Region: Bac_transf; pfam02397
335659016263	Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149
335659016264	phosphoprotein phosphatases of the metallophosphatase superfamily, metallophosphatase domain; Region: MPP_PPP_family; cd00144
335659016265	active site
335659016266	metal binding site [ion binding]; metal-binding site
335659016267	chemotaxis-specific methylesterase; Provisional; Region: PRK00742
335659016268	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
335659016269	active site
335659016270	phosphorylation site [posttranslational modification]
335659016271	intermolecular recognition site; other site
335659016272	dimerization interface [polypeptide binding]; other site
335659016273	CheB methylesterase; Region: CheB_methylest; pfam01339
335659016274	CheR methyltransferase, all-alpha domain; Region: CheR_N; pfam03705
335659016275	Methyltransferase, chemotaxis proteins; Region: MeTrc; smart00138
335659016276	CheR methyltransferase, SAM binding domain; Region: CheR; pfam01739
335659016277	Four helix bundle sensory module for signal transduction; Region: 4HB_MCP_1; pfam12729
335659016278	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054
335659016279	dimerization interface [polypeptide binding]; other site
335659016280	Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283
335659016281	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
335659016282	dimer interface [polypeptide binding]; other site
335659016283	putative CheW interface [polypeptide binding]; other site
335659016284	CheW, a small regulator protein, unique to the chemotaxis signalling in prokaryotes and archea. CheW interacts with the histidine kinase CheA, most likely with the related regulatory domain of CheA. CheW is proposed to form signalling arrays together...; Region: CheW; cd00732
335659016285	putative CheA interaction surface; other site
335659016286	Four helix bundle sensory module for signal transduction; Region: 4HB_MCP_1; pfam12729
335659016287	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054
335659016288	dimerization interface [polypeptide binding]; other site
335659016289	Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283
335659016290	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
335659016291	dimer interface [polypeptide binding]; other site
335659016292	putative CheW interface [polypeptide binding]; other site
335659016293	CheW-like domain. CheW proteins are part of the chemotaxis signalling mechanism in bacteria. CheW interacts with the methyl accepting chemotaxis proteins (MCPs) and relays signals to CheY, which affects flageller rotation. This family includes CheW and...; Region: CheW_like; cl00256
335659016294	Chemotaxis protein histidine kinase and related kinases [Cell motility and secretion / Signal transduction mechanisms]; Region: CheA; COG0643
335659016295	Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088
335659016296	putative binding surface; other site
335659016297	active site
335659016298	Signal transducing histidine kinase, homodimeric domain; Region: H-kinase_dim; pfam02895
335659016299	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
335659016300	ATP binding site [chemical binding]; other site
335659016301	Mg2+ binding site [ion binding]; other site
335659016302	G-X-G motif; other site
335659016303	CheA regulatory domain; CheA is a histidine protein kinase present in bacteria and archea. Activated by the chemotaxis receptor a histidine phosphoryl group from CheA is passed directly to an aspartate in the response regulator CheY. This signalling...; Region: CheA_reg; cd00731
335659016304	Response regulator receiver domain; Region: Response_reg; pfam00072
335659016305	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
335659016306	active site
335659016307	phosphorylation site [posttranslational modification]
335659016308	intermolecular recognition site; other site
335659016309	dimerization interface [polypeptide binding]; other site
335659016310	Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function; Region: STAS_SulP_like_sulfate_transporter; cd07042
335659016311	Response regulator containing a CheY-like receiver domain and an HD-GYP domain [Transcription / Signal transduction mechanisms]; Region: COG3437
335659016312	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
335659016313	active site
335659016314	phosphorylation site [posttranslational modification]
335659016315	intermolecular recognition site; other site
335659016316	dimerization interface [polypeptide binding]; other site
335659016317	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
335659016318	Zn2+ binding site [ion binding]; other site
335659016319	Mg2+ binding site [ion binding]; other site
335659016320	CHASE2 domain; Region: CHASE2; pfam05226
335659016321	Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114
335659016322	cyclase homology domain; Region: CHD; cd07302
335659016323	nucleotidyl binding site; other site
335659016324	metal binding site [ion binding]; metal-binding site
335659016325	dimer interface [polypeptide binding]; other site
335659016326	4-hydroxybenzoate 3-monooxygenase; Region: pbenz_hydroxyl; TIGR02360
335659016327	ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314
335659016328	4-hydroxyphenylacetate catabolism regulatory protein HpaA; Region: HpaA; TIGR02297
335659016329	AraC-like ligand binding domain; Region: AraC_binding; pfam02311
335659016330	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
335659016331	Transcriptional regulator containing an amidase domain and an AraC-type DNA-binding HTH domain [Transcription]; Region: COG4977
335659016332	AraC transcriptional regulators having a Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GATase1_AraC_1; cd03137
335659016333	conserved cys residue [active]
335659016334	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
335659016335	Putative intracellular protease/amidase [General function prediction only]; Region: ThiJ; COG0693
335659016336	Type 1 glutamine amidotransferase (GATase1)-like domain found in a subgroup of proteins similar to PfpI from Pyrococcus furiosus; Region: GATase1_PfpI_2; cd03139
335659016337	conserved cys residue [active]
335659016338	Protocatechuate 3,4-dioxygenase beta subunit [Secondary metabolites biosynthesis, transport, and catabolism]; Region: PcaH; COG3485
335659016339	Protocatechuate 3,4-dioxygenase (3,4-PCD) , alpha subunit. 3,4-PCD catalyzes the oxidative ring cleavage of 3,4-dihydroxybenzoate to produce beta-carboxy-cis,cis-muconate. 3,4-PCDs are large aggregates of 12 protomers, each composed of an alpha- and...; Region: 3,4-PCD_alpha; cd03463
335659016340	heterodimer interface [polypeptide binding]; other site
335659016341	active site
335659016342	Protocatechuate 3,4-dioxygenase (3,4-PCD) , beta subunit. 3,4-PCD catalyzes the oxidative ring cleavage of 3,4-dihydroxybenzoate to produce beta-carboxy-cis,cis-muconate. 3,4-PCDs are large aggregates of 12 protomers, each composed of an alpha- and...; Region: 3,4-PCD_beta; cd03464
335659016343	heterodimer interface [polypeptide binding]; other site
335659016344	multimer interface [polypeptide binding]; other site
335659016345	protocatechuate 3,4-dioxygenase, beta subunit; Region: protocat_beta; TIGR02422
335659016346	active site
335659016347	Transcriptional regulator [Transcription]; Region: LysR; COG0583
335659016348	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
335659016349	The C-terminal substrate binding domain of LysR-type transcriptional regulators that involved in the catabolism of nitroaromatic/naphthalene compounds and that of related regulators; contains the type 2 periplasmic binding fold; Region: PBP2_Nitroaromatics_like; cd08417
335659016350	substrate binding pocket [chemical binding]; other site
335659016351	dimerization interface [polypeptide binding]; other site
335659016352	Nicotinic acid phosphoribosyltransferase [Coenzyme metabolism]; Region: PncB; COG1488
335659016353	nicotinate phosphoribosyltransferase; Provisional; Region: PRK05321
335659016354	active site
335659016355	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
335659016356	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
335659016357	metal binding site [ion binding]; metal-binding site
335659016358	active site
335659016359	I-site; other site
335659016360	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
335659016361	WHG domain; Region: WHG; pfam13305
335659016362	acylglycerophosphoethanolamine acyltransferase; Provisional; Region: PRK06814
335659016363	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
335659016364	putative substrate translocation pore; other site
335659016365	Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989
335659016366	putative acyl-acceptor binding pocket; other site
335659016367	C-terminal domain of the acyl-acyl carrier protein synthetase (also called 2-acylglycerophosphoethanolamine acyltransferase, Aas); Region: AAS_C; cd05909
335659016368	acyl-activating enzyme (AAE) consensus motif; other site
335659016369	putative AMP binding site [chemical binding]; other site
335659016370	Predicted acetyltransferases and hydrolases with the alpha/beta hydrolase fold [General function prediction only]; Region: LipA; COG1075
335659016371	PGAP1-like protein; Region: PGAP1; pfam07819
335659016372	Disulfide bond formation protein DsbB [Posttranslational modification, protein turnover, chaperones]; Region: DsbB; COG1495
335659016373	tricarballylate utilization protein B; Provisional; Region: PRK15033
335659016374	tricarballylate dehydrogenase; Validated; Region: PRK08274
335659016375	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
335659016376	Transcriptional regulators [Transcription]; Region: FadR; COG2186
335659016377	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
335659016378	DNA-binding site [nucleotide binding]; DNA binding site
335659016379	FCD domain; Region: FCD; pfam07729
335659016380	helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346
335659016381	Transcriptional regulator [Transcription]; Region: IclR; COG1414
335659016382	Bacterial transcriptional regulator; Region: IclR; pfam01614
335659016383	3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084
335659016384	6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599
335659016385	Periplasmic binding protein; Region: Peripla_BP_6; pfam13458
335659016386	Periplasmic solute-binding domain of active transport proteins that belong to the type I periplasmic binding fold protein family; Region: PBP1_SBP_like_1; cd06327
335659016387	putative ligand binding site [chemical binding]; other site
335659016388	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
335659016389	This CD includes cysteinyl-tRNA(Pro) deacylases from Haemophilus influenzae and Escherichia coli and other related bacterial proteins. These trans-acting, single-domain proteins are homologs of ProX and also the cis-acting prolyl-tRNA synthetase (ProRS)...; Region: YbaK_deacylase; cd00002
335659016390	putative deacylase active site [active]
335659016391	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
335659016392	Uncharacterized anaerobic dehydrogenase [General function prediction only]; Region: COG3383
335659016393	catalytic loop [active]
335659016394	iron binding site [ion binding]; other site
335659016395	The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655
335659016396	Formate dehydrogenase H (Formate-Dh-H) catalyzes the reversible oxidation of formate to CO2 with the release of a proton and two electrons. It is a component of the anaerobic formate hydrogen lyase complex. The E. coli formate dehydrogenase H (Fdh-H) is...; Region: MopB_Formate-Dh-H; cd02753
335659016397	[4Fe-4S] binding site [ion binding]; other site
335659016398	molybdopterin cofactor binding site; other site
335659016399	Formate dehydrogenase H (Formate-Dh-H) catalyzes the reversible oxidation of formate to CO2 with the release of a proton and two electrons. It is a component of the anaerobic formate hydrogen lyase complex. The E. coli formate dehydrogenase H (Fdh-H) is...; Region: MopB_CT_Formate-Dh_H; cd02790
335659016400	molybdopterin cofactor binding site; other site
335659016401	NADH dehydrogenase subunit E; Validated; Region: PRK07539
335659016402	TRX-like [2Fe-2S] Ferredoxin (Fd) family, NADH:ubiquinone oxidoreductase (Nuo) subunit E family, Tungsten-containing formate dehydrogenase (W-FDH) beta subunit; composed of proteins similar to the W-FDH beta subunit of Methylobacterium extorquens. W-FDH...; Region: TRX_Fd_NuoE_W_FDH_beta; cd03082
335659016403	putative dimer interface [polypeptide binding]; other site
335659016404	[2Fe-2S] cluster binding site [ion binding]; other site
335659016405	NADH:ubiquinone oxidoreductase, NADH-binding (51 kD) subunit [Energy production and conversion]; Region: NuoF; COG1894
335659016406	SLBB domain; Region: SLBB; pfam10531
335659016407	NADH-ubiquinone oxidoreductase-F iron-sulfur binding region; Region: NADH_4Fe-4S; smart00928
335659016408	oxalate/formate antiporter; Region: oxa_formateAnti; TIGR04259
335659016409	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
335659016410	SirA, YedF, and YeeD. Two-layered alpha/beta sandwich domain.  SirA (also known as UvrY,  and YhhP) belongs to a family of bacterial two-component response regulators that controls secondary metabolism and virulence. The other member of this...; Region: SirA_YedF_YeeD; cd00291
335659016411	CPxP  motif; other site
335659016412	Molybdopterin biosynthesis enzyme [Coenzyme metabolism]; Region: MoeA; COG0303
335659016413	MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoeA; cd00887
335659016414	dimer interface [polypeptide binding]; other site
335659016415	putative functional site; other site
335659016416	putative MPT binding site; other site
335659016417	Molybdenum is an essential trace element in the form of molybdenum cofactor (Moco) which is associated with the metabolism of nitrogen, carbon and sulfur by redox active enzymes. In E. coli, the synthesis of Moco involves genes from several loci: moa; Region: MobB; cd03116
335659016418	Walker A motif; other site
335659016419	FdhD/NarQ family; Region: FdhD-NarQ; pfam02634
335659016420	molybdopterin-guanine dinucleotide biosynthesis protein MobA; Reviewed; Region: mobA; PRK00317
335659016421	MobA catalyzes the formation of molybdopterin guanine dinucleotide; Region: MobA; cd02503
335659016422	GTP binding site; other site
335659016423	putative molybdopterin biosynthesis protein MoeA/LysR substrate binding-domain-containing protein; Provisional; Region: PRK14498
335659016424	MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoeA; cd00887
335659016425	dimer interface [polypeptide binding]; other site
335659016426	putative functional site; other site
335659016427	putative MPT binding site; other site
335659016428	PBP superfamily domain; Region: PBP_like; pfam12727
335659016429	MoCF_BD: molybdenum cofactor (MoCF) binding domain (BD). This domain is found a variety of proteins involved in biosynthesis of molybdopterin cofactor, like MoaB, MogA, and MoeA. The domain is presumed to bind molybdopterin; Region: MoCF_BD; cl00451
335659016430	MPT binding site; other site
335659016431	PBP superfamily domain; Region: PBP_like_2; pfam12849
335659016432	Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531
335659016433	Helix-turn-helix domain; Region: HTH_17; pfam12728
335659016434	PBP superfamily domain; Region: PBP_like; pfam12727
335659016435	Periplasmic binding protein; Region: Peripla_BP_6; pfam13458
335659016436	Periplasmic solute-binding domain of active transport proteins that belong to the type I periplasmic binding fold protein family; Region: PBP1_SBP_like_1; cd06327
335659016437	putative ligand binding site [chemical binding]; other site
335659016438	TRAP transporter solute receptor, TAXI family; Region: TRAP_TAXI; TIGR02122
335659016439	TRAP-type uncharacterized transport system, periplasmic component [General function prediction only]; Region: Imp; COG2358
335659016440	Tripartite tricarboxylate transporter family receptor; Region: TctC; cl17792
335659016441	Protein of unknown function DUF262; Region: DUF262; pfam03235
335659016442	Uncharacterized conserved protein [Function unknown]; Region: COG1479
335659016443	HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085
335659016444	active site
335659016445	HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085
335659016446	Restriction endonuclease [Defense mechanisms]; Region: McrA; COG1403
335659016447	active site
335659016448	Phage derived protein Gp49-like (DUF891); Region: Gp49; pfam05973
335659016449	Globins are heme proteins, which bind and transport oxygen. This family summarizes a diverse set of homologous protein domains, including: (1) tetrameric vertebrate hemoglobins, which are the major protein component of erythrocytes and transport oxygen...; Region: globin; cd01040
335659016450	heme-binding site [chemical binding]; other site
335659016451	Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114
335659016452	cyclase homology domain; Region: CHD; cd07302
335659016453	nucleotidyl binding site; other site
335659016454	metal binding site [ion binding]; metal-binding site
335659016455	dimer interface [polypeptide binding]; other site
335659016456	Opacity protein and related surface antigens [Cell envelope biogenesis, outer membrane]; Region: COG3637
335659016457	Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114
335659016458	cyclase homology domain; Region: CHD; cd07302
335659016459	nucleotidyl binding site; other site
335659016460	metal binding site [ion binding]; metal-binding site
335659016461	dimer interface [polypeptide binding]; other site
335659016462	HutD; Region: HutD; pfam05962
335659016463	Aerobic-type carbon monoxide dehydrogenase, large subunit CoxL/CutL homologs [Energy production and conversion]; Region: CoxL; COG1529
335659016464	Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738
335659016465	Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; smart01008
335659016466	Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738
335659016467	Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738
335659016468	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
335659016469	Aerobic-type carbon monoxide dehydrogenase, small subunit CoxS/CutS homologs [Energy production and conversion]; Region: CoxS; COG2080
335659016470	catalytic loop [active]
335659016471	iron binding site [ion binding]; other site
335659016472	[2Fe-2S] binding domain; Region: Fer2_2; pfam01799
335659016473	3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653
335659016474	classical (c) SDRs; Region: SDR_c; cd05233
335659016475	NAD(P) binding site [chemical binding]; other site
335659016476	active site
335659016477	uncharacterized peroxidase-related enzyme; Region: peroxid_rel; TIGR01926
335659016478	Carboxymuconolactone decarboxylase family; Region: CMD; pfam02627
335659016479	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
335659016480	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
335659016481	Type I periplasmic ligand-binding domain of uncharacterized ABC (ATPase Binding Cassette)-type active transport systems that are predicted to be involved in uptake of amino acids, peptides, or inorganic ions; Region: PBP1_ABC_ligand_binding_like_8; cd06343
335659016482	Periplasmic binding protein; Region: Peripla_BP_6; pfam13458
335659016483	putative ligand binding site [chemical binding]; other site
335659016484	Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849
335659016485	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3181
335659016486	Methylmalonyl-CoA epimerase (MMCE); Region: MMCE; cd07249
335659016487	dimer interface [polypeptide binding]; other site
335659016488	substrate binding site [chemical binding]; other site
335659016489	metal binding site [ion binding]; metal-binding site
335659016490	ubiE/COQ5 methyltransferase family; Region: Ubie_methyltran; pfam01209
335659016491	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
335659016492	hypothetical protein; Provisional; Region: PRK12472
335659016493	L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734
335659016494	Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804
335659016495	CoA-transferase family III; Region: CoA_transf_3; pfam02515
335659016496	Type I periplasmic ligand-binding domain of uncharacterized ABC (ATPase Binding Cassette)-type active transport systems that are predicted to be involved in uptake of amino acids, peptides, or inorganic ions; Region: PBP1_ABC_ligand_binding_like_8; cd06343
335659016497	Periplasmic binding protein; Region: Peripla_BP_6; pfam13458
335659016498	putative ligand binding site [chemical binding]; other site
335659016499	ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410
335659016500	ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224
335659016501	Walker A/P-loop; other site
335659016502	ATP binding site [chemical binding]; other site
335659016503	Q-loop/lid; other site
335659016504	ABC transporter signature motif; other site
335659016505	Walker B; other site
335659016506	D-loop; other site
335659016507	H-loop/switch region; other site
335659016508	ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219
335659016509	ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411
335659016510	Walker A/P-loop; other site
335659016511	ATP binding site [chemical binding]; other site
335659016512	Q-loop/lid; other site
335659016513	ABC transporter signature motif; other site
335659016514	Walker B; other site
335659016515	D-loop; other site
335659016516	H-loop/switch region; other site
335659016517	ABC-type branched-chain amino acid transport system, permease component [Amino acid transport and metabolism]; Region: LivM; COG4177
335659016518	Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581
335659016519	TM-ABC transporter signature motif; other site
335659016520	Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582
335659016521	TM-ABC transporter signature motif; other site
335659016522	Periplasmic binding protein; Region: Peripla_BP_6; pfam13458
335659016523	Periplasmic solute-binding domain of active transport proteins; Region: PBP1_SBP_like_3; cd06329
335659016524	putative ligand binding site [chemical binding]; other site
335659016525	Fatty acid desaturase [Lipid metabolism]; Region: DesA; COG3239
335659016526	The Delta12 Fatty Acid Desaturase (Delta12-FADS)-like CD includes the integral-membrane enzymes, delta-12 acyl-lipid desaturases, oleate 12-hydroxylases, omega3 and omega6 fatty acid desaturases, and other related proteins, found in a wide range of...; Region: Delta12-FADS-like; cd03507
335659016527	putative di-iron ligands [ion binding]; other site
335659016528	cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664
335659016529	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
335659016530	ligand binding site [chemical binding]; other site
335659016531	flexible hinge region; other site
335659016532	helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092
335659016533	non-specific DNA interactions [nucleotide binding]; other site
335659016534	DNA binding site [nucleotide binding]
335659016535	sequence specific DNA binding site [nucleotide binding]; other site
335659016536	putative cAMP binding site [chemical binding]; other site
335659016537	Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244
335659016538	Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326
335659016539	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
335659016540	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013
335659016541	Glycosyl hydrolase family 10; Region: Glyco_hydro_10; cl01495
335659016542	protein-L-isoaspartate O-methyltransferase; Provisional; Region: PRK13944
335659016543	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
335659016544	S-adenosylmethionine binding site [chemical binding]; other site
335659016545	SAM (Sterile alpha motif ); Region: SAM_superfamily; cd09487
335659016546	Sterile alpha motif; Region: SAM; smart00454
335659016547	Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114
335659016548	cyclase homology domain; Region: CHD; cd07302
335659016549	nucleotidyl binding site; other site
335659016550	metal binding site [ion binding]; metal-binding site
335659016551	dimer interface [polypeptide binding]; other site
335659016552	Predicted ATPase [General function prediction only]; Region: COG3899
335659016553	AAA ATPase domain; Region: AAA_16; pfam13191
335659016554	Predicted ATPase [General function prediction only]; Region: COG3903
335659016555	Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318
335659016556	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
335659016557	Subfamily of fatty acid CoA ligase (FACL) similar to Fum10p of Gibberella moniliformis; Region: FACL_fum10p_like; cd05926
335659016558	acyl-activating enzyme (AAE) consensus motif; other site
335659016559	acyl-activating enzyme (AAE) consensus motif; other site
335659016560	putative AMP binding site [chemical binding]; other site
335659016561	putative active site [active]
335659016562	putative CoA binding site [chemical binding]; other site
335659016563	Phosphopantetheine attachment site; Region: PP-binding; pfam00550
335659016564	Condensation domain; Region: Condensation; pfam00668
335659016565	Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020
335659016566	HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745
335659016567	The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930
335659016568	acyl-activating enzyme (AAE) consensus motif; other site
335659016569	AMP binding site [chemical binding]; other site
335659016570	Phosphopantetheine attachment site; Region: PP-binding; pfam00550
335659016571	Condensation domain; Region: Condensation; pfam00668
335659016572	Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020
335659016573	HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745
335659016574	Phosphopantetheinyl transferase [Coenzyme metabolism]; Region: Sfp; COG2091
335659016575	4'-phosphopantetheinyl transferase superfamily; Region: ACPS; pfam01648
335659016576	Luciferase-like monooxygenase; Region: Bac_luciferase; pfam00296
335659016577	Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892
335659016578	Histone deacetylase class IIa; Region: HDAC_classII_APAH; cd10001
335659016579	Deacetylases, including yeast histone deacetylase and acetoin utilization protein [Chromatin structure and dynamics / Secondary metabolites biosynthesis, transport, and catabolism]; Region: AcuC; COG0123
335659016580	active site
335659016581	Zn binding site [ion binding]; other site
335659016582	Gluconolactonase [Carbohydrate transport and metabolism]; Region: COG3386
335659016583	Glucose/sorbosone dehydrogenases [Carbohydrate transport and metabolism]; Region: COG2133
335659016584	enoyl-CoA hydratase; Provisional; Region: PRK05981
335659016585	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
335659016586	substrate binding site [chemical binding]; other site
335659016587	oxyanion hole (OAH) forming residues; other site
335659016588	trimer interface [polypeptide binding]; other site
335659016589	Gamma-glutamyltransferase [Amino acid transport and metabolism]; Region: Ggt; cl08040
335659016590	Gamma-glutamyltranspeptidase; Region: G_glu_transpept; pfam01019
335659016591	Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665
335659016592	putative aminophosphonate oxidoreductase; Region: Phn_aa_oxid; TIGR03329
335659016593	ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126
335659016594	ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262
335659016595	Walker A/P-loop; other site
335659016596	ATP binding site [chemical binding]; other site
335659016597	Q-loop/lid; other site
335659016598	ABC transporter signature motif; other site
335659016599	Walker B; other site
335659016600	D-loop; other site
335659016601	H-loop/switch region; other site
335659016602	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097
335659016603	ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215
335659016604	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
335659016605	dimer interface [polypeptide binding]; other site
335659016606	conserved gate region; other site
335659016607	putative PBP binding loops; other site
335659016608	ABC-ATPase subunit interface; other site
335659016609	Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497
335659016610	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
335659016611	substrate binding pocket [chemical binding]; other site
335659016612	membrane-bound complex binding site; other site
335659016613	hinge residues; other site
335659016614	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
335659016615	sequence-specific DNA binding site [nucleotide binding]; other site
335659016616	salt bridge; other site
335659016617	Cupin domain; Region: Cupin_2; pfam07883
335659016618	D-amino acid dehydrogenase small subunit; Validated; Region: PRK00711
335659016619	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
335659016620	hydroxyglutarate oxidase; Provisional; Region: PRK11728
335659016621	beta alanine--pyruvate transaminase; Provisional; Region: PRK09221
335659016622	Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610
335659016623	inhibitor-cofactor binding pocket; inhibition site
335659016624	pyridoxal 5'-phosphate binding site [chemical binding]; other site
335659016625	catalytic residue [active]
335659016626	DNA-binding transcriptional repressor PuuR; Provisional; Region: PRK09943
335659016627	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
335659016628	non-specific DNA binding site [nucleotide binding]; other site
335659016629	salt bridge; other site
335659016630	sequence-specific DNA binding site [nucleotide binding]; other site
335659016631	Cupin domain; Region: Cupin_2; pfam07883
335659016632	Aerobic-type carbon monoxide dehydrogenase, large subunit CoxL/CutL homologs [Energy production and conversion]; Region: CoxL; COG1529
335659016633	Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; smart01008
335659016634	Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738
335659016635	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM/CutM homologs [Energy production and conversion]; Region: CoxM; COG1319
335659016636	CO dehydrogenase flavoprotein C-terminal domain; Region: CO_deh_flav_C; smart01092
335659016637	Aerobic-type carbon monoxide dehydrogenase, small subunit CoxS/CutS homologs [Energy production and conversion]; Region: CoxS; COG2080
335659016638	[2Fe-2S] binding domain; Region: Fer2_2; pfam01799
335659016639	transcriptional repressor BetI; Region: betaine_BetI; TIGR03384
335659016640	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
335659016641	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
335659016642	Major Facilitator Superfamily; Region: MFS_1; pfam07690
335659016643	putative substrate translocation pore; other site
335659016644	Outer membrane efflux protein; Region: OEP; pfam02321
335659016645	Putative multicopper oxidases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: SufI; COG2132
335659016646	Multicopper oxidase; Region: Cu-oxidase_3; pfam07732
335659016647	Multicopper oxidase; Region: Cu-oxidase_2; pfam07731
335659016648	Uncharacterized copper-binding protein [Inorganic ion transport and metabolism]; Region: COG4454
335659016649	Copper binding periplasmic protein CusF; Region: CusF_Ec; pfam11604
335659016650	flagellar biosynthesis protein FlhA; Validated; Region: flhA; PRK06012
335659016651	FHIPEP family; Region: FHIPEP; pfam00771
335659016652	Lytic Transglycosylase (LT)  and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL).  LTs...; Region: LT_GEWL; cd00254
335659016653	N-acetyl-D-glucosamine binding site [chemical binding]; other site
335659016654	catalytic residue [active]
335659016655	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
335659016656	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
335659016657	Anti-sigma-K factor rskA; Region: RskA; pfam10099
335659016658	RNA polymerase sigma factor; Provisional; Region: PRK12514
335659016659	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
335659016660	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
335659016661	DNA binding residues [nucleotide binding]
335659016662	flagellar export protein FliJ; Region: flagell_FliJ; TIGR02473
335659016663	flagellum-specific ATP synthase; Validated; Region: fliI; PRK08927
335659016664	ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874
335659016665	Flagellum-specific ATPase/type III secretory pathway virulence-related protein. This group of ATPases are responsible for the export of flagellum and virulence-related proteins. The bacterial flagellar motor is similar to the F0F1-ATPase, in that they...; Region: ATPase_flagellum-secretory_path_III; cd01136
335659016666	Walker A motif/ATP binding site; other site
335659016667	Walker B motif; other site
335659016668	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
335659016669	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
335659016670	active site
335659016671	phosphorylation site [posttranslational modification]
335659016672	intermolecular recognition site; other site
335659016673	dimerization interface [polypeptide binding]; other site
335659016674	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
335659016675	DNA binding site [nucleotide binding]
335659016676	Predicted membrane protein [Function unknown]; Region: COG3766
335659016677	Domain of Unknown Function (DUF350); Region: DUF350; pfam03994
335659016678	Glutathionylspermidine synthase [Amino acid transport and metabolism]; Region: Gsp; COG0754
335659016679	CheR methyltransferase, all-alpha domain; Region: CheR_N; pfam03705
335659016680	Methylase of chemotaxis methyl-accepting proteins [Cell motility and secretion / Signal transduction mechanisms]; Region: CheR; COG1352
335659016681	CheR methyltransferase, SAM binding domain; Region: CheR; pfam01739
335659016682	chemotaxis-specific methylesterase; Provisional; Region: PRK00742
335659016683	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
335659016684	active site
335659016685	phosphorylation site [posttranslational modification]
335659016686	intermolecular recognition site; other site
335659016687	dimerization interface [polypeptide binding]; other site
335659016688	CheB methylesterase; Region: CheB_methylest; pfam01339
335659016689	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
335659016690	Response regulator receiver domain; Region: Response_reg; pfam00072
335659016691	active site
335659016692	phosphorylation site [posttranslational modification]
335659016693	intermolecular recognition site; other site
335659016694	dimerization interface [polypeptide binding]; other site
335659016695	CheW-like domain. CheW proteins are part of the chemotaxis signalling mechanism in bacteria. CheW interacts with the methyl accepting chemotaxis proteins (MCPs) and relays signals to CheY, which affects flageller rotation. This family includes CheW and...; Region: CheW_like; cl00256
335659016696	Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088
335659016697	putative binding surface; other site
335659016698	active site
335659016699	Chemotaxis protein histidine kinase and related kinases [Cell motility and secretion / Signal transduction mechanisms]; Region: CheA; COG0643
335659016700	Signal transducing histidine kinase, homodimeric domain; Region: H-kinase_dim; pfam02895
335659016701	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
335659016702	ATP binding site [chemical binding]; other site
335659016703	Mg2+ binding site [ion binding]; other site
335659016704	G-X-G motif; other site
335659016705	CheA regulatory domain; CheA is a histidine protein kinase present in bacteria and archea. Activated by the chemotaxis receptor a histidine phosphoryl group from CheA is passed directly to an aspartate in the response regulator CheY. This signalling...; Region: CheA_reg; cd00731
335659016706	CheW-like domain; Region: CheW; pfam01584
335659016707	Response regulator receiver domain; Region: Response_reg; pfam00072
335659016708	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
335659016709	active site
335659016710	phosphorylation site [posttranslational modification]
335659016711	intermolecular recognition site; other site
335659016712	dimerization interface [polypeptide binding]; other site
335659016713	Uncharacterized protein conserved in bacteria (DUF2328); Region: DUF2328; pfam10090
335659016714	CysQ, a 3'-Phosphoadenosine-5'-phosphosulfate (PAPS) 3'-phosphatase, is a bacterial member of the inositol monophosphatase family. It has been proposed that CysQ helps control intracellular levels of PAPS, which is an intermediate in...; Region: CysQ; cd01638
335659016715	Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483
335659016716	active site
335659016717	Ribosomal protein L24e/L24 is a ribosomal protein found in eukaryotes (L24) and in archaea (L24e, distinct from archaeal L24). L24e/L24 is located on the surface of the large subunit, adjacent to proteins L14 and L3, and near the translation factor...; Region: Ribosomal_L24e_L24; cl00909
335659016718	Protein of unknown function (DUF1134); Region: DUF1134; pfam06577
335659016719	chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168
335659016720	potential protein location (hypothetical protein S23_58370 [Bradyrhizobium sp. S23321]) that overlaps RNA (tRNA-V)
335659016721	Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586
335659016722	transcription elongation factor regulatory protein; Validated; Region: PRK06342
335659016723	Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272
335659016724	Protein of unknown function (DUF3551); Region: DUF3551; pfam12071
335659016725	Uncharacterized bacterial family of heme peroxidases; Region: An_peroxidase_bacterial_1; cd09819
335659016726	putative heme binding site [chemical binding]; other site
335659016727	putative substrate binding site [chemical binding]; other site
335659016728	Cupin; Region: Cupin_6; pfam12852
335659016729	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
335659016730	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
335659016731	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
335659016732	methyl indole-3-acetate methyltransferase; Region: PLN02211; cl17657
335659016733	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
335659016734	Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596
335659016735	TAP-like protein; Region: Abhydrolase_4; pfam08386
335659016736	Domain of unknown function DUF302; Region: DUF302; pfam03625
335659016737	Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376
335659016738	L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734
335659016739	hypothetical protein; Validated; Region: PRK07586
335659016740	Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035
335659016741	PYR/PP interface [polypeptide binding]; other site
335659016742	dimer interface [polypeptide binding]; other site
335659016743	TPP binding site [chemical binding]; other site
335659016744	Thiamine pyrophosphate (TPP) family, BFDC subfamily, TPP-binding module; composed of proteins similar to Pseudomonas putida benzoylformate decarboxylase (BFDC). P. putida BFDC plays a role in the mandelate pathway, catalyzing the conversion of...; Region: TPP_BFDC; cd02002
335659016745	TPP-binding site [chemical binding]; other site
335659016746	dimer interface [polypeptide binding]; other site
335659016747	Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376
335659016748	L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734
335659016749	Protein of unknown function (DUF2927); Region: DUF2927; pfam11150
335659016750	Glycosyl transferases group 1; Region: Glyco_trans_1_4; pfam13692
335659016751	threonine synthase; Validated; Region: PRK08197
335659016752	Threonine synthase is a pyridoxal phosphate (PLP) dependent enzyme that catalyses the last reaction in the synthesis of  threonine from aspartate. It proceeds by converting O-phospho-L-homoserine (OPH) into threonine and inorganic phosphate. In plants; Region: Thr-synth_1; cd01563
335659016753	homodimer interface [polypeptide binding]; other site
335659016754	pyridoxal 5'-phosphate binding site [chemical binding]; other site
335659016755	catalytic residue [active]
335659016756	Glyoxalase-like domain; Region: Glyoxalase_3; pfam13468
335659016757	hypothetical protein; Validated; Region: PRK07198
335659016758	GTP cyclohydrolase N terminal; Region: GTP_CH_N; pfam12471
335659016759	GTP cyclohydrolase II (RibA).  GTP cyclohydrolase II catalyzes the conversion of GTP to 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5' phosphate, formate, pyrophosphate (APy), and GMP in the biosynthetic pathway of riboflavin. Riboflavin is the...; Region: GTP_cyclohydro2; cd00641
335659016760	dimerization interface [polypeptide binding]; other site
335659016761	active site
335659016762	Protein of unknown function (DUF1688); Region: DUF1688; pfam07958
335659016763	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
335659016764	active site
335659016765	Zn-dependent protease with chaperone function [Posttranslational modification, protein turnover, chaperones]; Region: HtpX; COG0501
335659016766	Bacterial protein of unknown function (DUF898); Region: DUF898; pfam05987
335659016767	Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124
335659016768	Cytochrome P450; Region: p450; cl12078
335659016769	Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124
335659016770	Cytochrome P450; Region: p450; cl12078
335659016771	Transcriptional regulator [Transcription]; Region: LysR; COG0583
335659016772	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
335659016773	The C-teminal substrate binding domain of LysR-like nitrogen assimilation control (NAC) protein, contains the type 2 periplasmic binding fold; Region: PBP2_Nac; cd08433
335659016774	putative dimerization interface [polypeptide binding]; other site
335659016775	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
335659016776	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
335659016777	active site
335659016778	Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804
335659016779	CoA-transferase family III; Region: CoA_transf_3; pfam02515
335659016780	Uncharacterized conserved protein [Function unknown]; Region: COG3777
335659016781	The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509
335659016782	The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509
335659016783	active site 2 [active]
335659016784	active site 1 [active]
335659016785	benzoylformate decarboxylase; Reviewed; Region: PRK07092
335659016786	Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035
335659016787	PYR/PP interface [polypeptide binding]; other site
335659016788	dimer interface [polypeptide binding]; other site
335659016789	TPP binding site [chemical binding]; other site
335659016790	Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205
335659016791	Thiamine pyrophosphate (TPP) family, BFDC subfamily, TPP-binding module; composed of proteins similar to Pseudomonas putida benzoylformate decarboxylase (BFDC). P. putida BFDC plays a role in the mandelate pathway, catalyzing the conversion of...; Region: TPP_BFDC; cd02002
335659016792	TPP-binding site [chemical binding]; other site
335659016793	dimer interface [polypeptide binding]; other site
335659016794	short chain dehydrogenase; Provisional; Region: PRK06172
335659016795	classical (c) SDRs; Region: SDR_c; cd05233
335659016796	NAD(P) binding site [chemical binding]; other site
335659016797	active site
335659016798	helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347
335659016799	Winged helix DNA-binding domain; Region: HTH_27; pfam13463
335659016800	3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK05565
335659016801	classical (c) SDRs; Region: SDR_c; cd05233
335659016802	NAD(P) binding site [chemical binding]; other site
335659016803	active site
335659016804	Predicted membrane protein, hemolysin III homolog [General function prediction only]; Region: COG1272
335659016805	channel protein, hemolysin III family; Region: hlyIII; TIGR01065
335659016806	YcjX-like family, DUF463; Region: DUF463; pfam04317
335659016807	hypothetical protein; Provisional; Region: PRK05415
335659016808	Domain of unknown function (DUF697); Region: DUF697; cl12064
335659016809	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family [Cell envelope biogenesis, outer membrane]; Region: ArnT; COG1807
335659016810	Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; pfam13231
335659016811	Cation efflux family; Region: Cation_efflux; cl00316
335659016812	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
335659016813	Ferredoxin [Energy production and conversion]; Region: Fdx; COG0633
335659016814	catalytic loop [active]
335659016815	iron binding site [ion binding]; other site
335659016816	Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114
335659016817	cyclase homology domain; Region: CHD; cd07302
335659016818	nucleotidyl binding site; other site
335659016819	metal binding site [ion binding]; metal-binding site
335659016820	dimer interface [polypeptide binding]; other site
335659016821	Sulfite oxidase (SO) family, molybdopterin binding domain. This molybdopterin cofactor (Moco) binding domain is found in a variety of oxidoreductases, main members of this family are nitrate reductase (NR) and sulfite oxidase (SO). SO catalyzes the...; Region: SO_family_Moco; cl00199
335659016822	sulfite oxidase; Provisional; Region: PLN00177
335659016823	Moco binding site; other site
335659016824	metal coordination site [ion binding]; other site
335659016825	Photosystem P840 reaction-centre cytochrome c-551; Region: Cytochrome-c551; pfam10643
335659016826	Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea.  CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458
335659016827	DNA-binding site [nucleotide binding]; DNA binding site
335659016828	RNA-binding motif; other site
335659016829	Transcriptional regulators [Transcription]; Region: Lrp; COG1522
335659016830	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
335659016831	putative DNA binding site [nucleotide binding]; other site
335659016832	putative Zn2+ binding site [ion binding]; other site
335659016833	AsnC family; Region: AsnC_trans_reg; pfam01037
335659016834	bifunctional proline dehydrogenase/pyrroline-5-carboxylate dehydrogenase; Reviewed; Region: PRK11904
335659016835	Proline dehydrogenase; Region: Pro_dh; pfam01619
335659016836	Delta(1)-pyrroline-5-carboxylate dehydrogenase, PutA; Region: ALDH_PutA-P5CDH; cd07125
335659016837	Glutamate binding site [chemical binding]; other site
335659016838	NAD binding site [chemical binding]; other site
335659016839	catalytic residues [active]
335659016840	Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804
335659016841	CoA-transferase family III; Region: CoA_transf_3; pfam02515
335659016842	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3226
335659016843	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
335659016844	Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388
335659016845	Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625
335659016846	C-terminal, alpha helical domain of the Glutathione S-transferase family; Region: GST_C_family; cl02776
335659016847	N-terminal domain interface [polypeptide binding]; other site
335659016848	dimer interface [polypeptide binding]; other site
335659016849	substrate binding pocket (H-site) [chemical binding]; other site
335659016850	Repair protein; Region: Repair_PSII; pfam04536
335659016851	Beta-propeller domains of methanol dehydrogenase type [General function prediction only]; Region: COG1512
335659016852	Repair protein; Region: Repair_PSII; pfam04536
335659016853	LemA family; Region: LemA; pfam04011
335659016854	enoyl-CoA hydratase; Provisional; Region: PRK08290
335659016855	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
335659016856	substrate binding site [chemical binding]; other site
335659016857	oxyanion hole (OAH) forming residues; other site
335659016858	trimer interface [polypeptide binding]; other site
335659016859	pimeloyl-CoA dehydrogenase, small subunit; Region: pimD_small; TIGR03203
335659016860	Acyl-CoA dehydrogenase; Region: ACAD; cd00567
335659016861	active site
335659016862	pimeloyl-CoA dehydrogenase, large subunit; Region: pimC_large; TIGR03204
335659016863	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
335659016864	active site
335659016865	Aerobic-type carbon monoxide dehydrogenase, large subunit CoxL/CutL homologs [Energy production and conversion]; Region: CoxL; COG1529
335659016866	Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; smart01008
335659016867	Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738
335659016868	Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329
335659016869	Dihydrodipicolinate synthase family; Region: DHDPS-like; cd00408
335659016870	inhibitor site; inhibition site
335659016871	active site
335659016872	dimer interface [polypeptide binding]; other site
335659016873	catalytic residue [active]
335659016874	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
335659016875	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
335659016876	metal binding site [ion binding]; metal-binding site
335659016877	active site
335659016878	I-site; other site
335659016879	Predicted ring-cleavage extradiol dioxygenase [General function prediction only]; Region: COG2514
335659016880	This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_12; cd07255
335659016881	putative metal binding site [ion binding]; other site
335659016882	This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632
335659016883	active site
335659016884	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]; Region: DegQ; COG0265
335659016885	Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365
335659016886	PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987
335659016887	protein binding site [polypeptide binding]; other site
335659016888	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
335659016889	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
335659016890	DNA binding residues [nucleotide binding]
335659016891	dimerization interface [polypeptide binding]; other site
335659016892	Transcriptional accessory protein [Transcription]; Region: Tex; COG2183
335659016893	Tex-like protein N-terminal domain; Region: Tex_N; pfam09371
335659016894	Likely ribonuclease with RNase H fold; Region: YqgFc; smart00732
335659016895	S1_Tex: The C-terminal S1 domain of a transcription accessory factor called Tex, which has been characterized in Bordetella pertussis and Pseudomonas aeruginosa. The tex gene is essential in Bortella pertusis and is named for its role in toxin expression; Region: S1_Tex; cd05685
335659016896	RNA binding site [nucleotide binding]; other site
335659016897	Amidohydrolase ring-opening protein (Amido_AtzD_TrzD); Region: Amido_AtzD_TrzD; pfam09663
335659016898	Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154
335659016899	Amidase; Region: Amidase; cl11426
335659016900	PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria.  Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443
335659016901	CoenzymeA binding site [chemical binding]; other site
335659016902	subunit interaction site [polypeptide binding]; other site
335659016903	PHB binding site; other site
335659016904	PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria.  Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443
335659016905	CoenzymeA binding site [chemical binding]; other site
335659016906	subunit interaction site [polypeptide binding]; other site
335659016907	PHB binding site; other site
335659016908	pyruvate dehydrogenase; Provisional; Region: PRK09124
335659016909	Pyrimidine (PYR) binding domain of POX; Region: TPP_PYR_POX; cd07039
335659016910	PYR/PP interface [polypeptide binding]; other site
335659016911	dimer interface [polypeptide binding]; other site
335659016912	tetramer interface [polypeptide binding]; other site
335659016913	TPP binding site [chemical binding]; other site
335659016914	Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205
335659016915	Thiamine pyrophosphate (TPP) family, Pyruvate oxidase (POX) subfamily, TPP-binding module; composed of proteins similar to Lactobacillus plantarum POX, which plays a key role in controlling acetate production under aerobic conditions. POX decarboxylates...; Region: TPP_POX; cd02014
335659016916	TPP-binding site [chemical binding]; other site
335659016917	2-dehydro-3-deoxy-6-phosphogalactonate aldolase; Reviewed; Region: PRK09140
335659016918	KDPG and KHG aldolase; Region: KDPG_aldolase; cd00452
335659016919	active site
335659016920	intersubunit interface [polypeptide binding]; other site
335659016921	catalytic residue [active]
335659016922	2-keto-3-deoxy-galactonokinase [Carbohydrate transport and metabolism]; Region: DgoK; COG3734
335659016923	2-keto-3-deoxy-galactonokinase; Region: DGOK; pfam05035
335659016924	Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892
335659016925	Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases [Energy production and conversion]; Region: COG2141
335659016926	Flavin reductase like domain; Region: Flavin_Reduct; smart00903
335659016927	Transcriptional activator of acetoin/glycerol metabolism [Secondary metabolites biosynthesis, transport, and catabolism / Transcription]; Region: AcoR; COG3284
335659016928	GAF domain; Region: GAF; pfam01590
335659016929	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
335659016930	Walker A motif; other site
335659016931	ATP binding site [chemical binding]; other site
335659016932	Walker B motif; other site
335659016933	arginine finger; other site
335659016934	Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954
335659016935	acetyl-CoA carboxylase biotin carboxylase subunit; Validated; Region: PRK08591
335659016936	Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289
335659016937	ATP-grasp domain; Region: ATP-grasp_4; cl17255
335659016938	Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; pfam02785
335659016939	Biotin carboxyl carrier protein [Lipid metabolism]; Region: AccB; COG0511
335659016940	The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850
335659016941	carboxyltransferase (CT) interaction site; other site
335659016942	biotinylation site [posttranslational modification]; other site
335659016943	Acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta) [Lipid metabolism]; Region: COG4799
335659016944	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cl15762
335659016945	oxyanion hole (OAH) forming residues; other site
335659016946	Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; cl17345
335659016947	Asp/Glu/Hydantoin racemase; Region: Asp_Glu_race; cl00518
335659016948	Transcriptional regulators [Transcription]; Region: FadR; COG2186
335659016949	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
335659016950	DNA-binding site [nucleotide binding]; DNA binding site
335659016951	FCD domain; Region: FCD; pfam07729
335659016952	ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842
335659016953	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
335659016954	Walker A/P-loop; other site
335659016955	ATP binding site [chemical binding]; other site
335659016956	Q-loop/lid; other site
335659016957	ABC transporter signature motif; other site
335659016958	Walker B; other site
335659016959	D-loop; other site
335659016960	H-loop/switch region; other site
335659016961	Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531
335659016962	Bacterial extracellular solute-binding protein; Region: SBP_bac_6; pfam13343
335659016963	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
335659016964	dimer interface [polypeptide binding]; other site
335659016965	conserved gate region; other site
335659016966	ABC-ATPase subunit interface; other site
335659016967	ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177
335659016968	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
335659016969	dimer interface [polypeptide binding]; other site
335659016970	conserved gate region; other site
335659016971	putative PBP binding loops; other site
335659016972	ABC-ATPase subunit interface; other site
335659016973	putative urate catabolism protein; Region: uraD_N-term-dom; TIGR03212
335659016974	Catalytic NodB homology domain of the carbohydrate esterase 4 superfamily; Region: CE4_SF; cl15692
335659016975	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
335659016976	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
335659016977	4-Oxalocrotonate Tautomerase:  Catalyzes the isomerization of unsaturated ketones. The structure is a homohexamer that is arranged as a trimer of dimers. The hexamer contains six active sites, each formed by residues from three monomers, two from one...; Region: 4Oxalocrotonate_Tautomerase; cl00235
335659016978	dimer interface [polypeptide binding]; other site
335659016979	hexamer interface [polypeptide binding]; other site
335659016980	active site 2 [active]
335659016981	Putative GTPases (G3E family) [General function prediction only]; Region: COG0523
335659016982	CobW/HypB/UreG, nucleotide-binding domain; Region: cobW; pfam02492
335659016983	Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; smart00833
335659016984	D-glutamate deacylase; Validated; Region: PRK09061
335659016985	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
335659016986	active site
335659016987	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
335659016988	active site
335659016989	Dipeptidyl aminopeptidases/acylaminoacyl-peptidases [Amino acid transport and metabolism]; Region: DAP2; COG1506
335659016990	Type-A lantibiotic; Region: L_biotic_typeA; pfam04604
335659016991	pseudouridine synthase, RluA family; Region: rluA_subfam; TIGR00005
335659016992	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
335659016993	RNA binding surface [nucleotide binding]; other site
335659016994	Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869
335659016995	active site
335659016996	RNA polymerase factor sigma-32; Reviewed; Region: PRK06596
335659016997	Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140
335659016998	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
335659016999	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
335659017000	DNA binding residues [nucleotide binding]
335659017001	Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583
335659017002	amidase catalytic site [active]
335659017003	Zn binding residues [ion binding]; other site
335659017004	substrate binding site [chemical binding]; other site
335659017005	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
335659017006	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
335659017007	metal binding site [ion binding]; metal-binding site
335659017008	active site
335659017009	I-site; other site
335659017010	Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280
335659017011	Response regulator receiver domain; Region: Response_reg; pfam00072
335659017012	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
335659017013	active site
335659017014	phosphorylation site [posttranslational modification]
335659017015	intermolecular recognition site; other site
335659017016	short chain dehydrogenase; Provisional; Region: PRK05650
335659017017	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
335659017018	NAD(P) binding site [chemical binding]; other site
335659017019	active site
335659017020	lytic murein transglycosylase; Region: MltB_2; TIGR02283
335659017021	murein hydrolase B; Provisional; Region: PRK10760; cl17906
335659017022	Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885
335659017023	Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185
335659017024	ligand binding site [chemical binding]; other site
335659017025	Sigma-70 factor, region 1.1; Region: Sigma70_r1_1; pfam03979
335659017026	Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140
335659017027	Sigma-70, non-essential region; Region: Sigma70_ner; pfam04546
335659017028	RNA polymerase sigma factor RpoD, C-terminal domain; Region: RpoD_Cterm; TIGR02393
335659017029	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
335659017030	Sigma-70 region 3; Region: Sigma70_r3; pfam04539
335659017031	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
335659017032	DNA binding residues [nucleotide binding]
335659017033	DNA primase, catalytic core; Region: dnaG; TIGR01391
335659017034	CHC2 zinc finger; Region: zf-CHC2; pfam01807
335659017035	DNA primase catalytic core, N-terminal domain; Region: Toprim_N; pfam08275
335659017036	TOPRIM_DnaG_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of proteins similar to Escherichia coli DnaG. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_DnaG_primases; cd03364
335659017037	active site
335659017038	metal binding site [ion binding]; metal-binding site
335659017039	interdomain interaction site; other site
335659017040	DnaB-helicase binding domain of primase; Region: DnaB_bind; pfam10410
335659017041	Chlorite dismutase; Region: Chlor_dismutase; cl01280
335659017042	GGCT-like domains, also called AIG2-like family. Gamma-glutamyl cyclotransferase (GGCT) catalyzes the formation of pyroglutamic acid (5-oxoproline) from dipeptides containing gamma-glutamyl, and is a dimeric protein. In Homo sapiens, the protein is...; Region: GGCT_like; cd06661
335659017043	putative active site pocket [active]
335659017044	dimerization interface [polypeptide binding]; other site
335659017045	putative catalytic residue [active]
335659017046	Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305
335659017047	Transglutaminase-like superfamily; Region: Transglut_core; pfam01841
335659017048	Bacterial transglutaminase-like N-terminal region; Region: Bact_transglu_N; pfam08379
335659017049	Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305
335659017050	Transglutaminase-like superfamily; Region: Transglut_core; pfam01841
335659017051	N-formylglutamate amidohydrolase; Region: FGase; cl01522
335659017052	Protein of unknown function (DUF3592); Region: DUF3592; pfam12158
335659017053	Protein of unknown function (DUF3592); Region: DUF3592; pfam12158
335659017054	Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280
335659017055	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
335659017056	dimerization interface [polypeptide binding]; other site
335659017057	putative DNA binding site [nucleotide binding]; other site
335659017058	putative Zn2+ binding site [ion binding]; other site
335659017059	Putative hydrophobic ligand-binding SRPBCC domain of an uncharacterized subgroup of CalC- and Aha1-like proteins; some contain an N-terminal GntR family winged HTH DNA-binding domain; Region: SRPBCC_CalC_Aha1-like_GntR-HTH; cd08893
335659017060	putative hydrophobic ligand binding site [chemical binding]; other site
335659017061	Putative hydrophobic ligand-binding SRPBCC domain of an uncharacterized subgroup of CalC- and Aha1-like proteins; some contain an N-terminal GntR family winged HTH DNA-binding domain; Region: SRPBCC_CalC_Aha1-like_GntR-HTH; cd08893
335659017062	putative hydrophobic ligand binding site [chemical binding]; other site
335659017063	Predicted integral membrane protein (DUF2189); Region: DUF2189; cl02291
335659017064	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
335659017065	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054
335659017066	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
335659017067	dimer interface [polypeptide binding]; other site
335659017068	phosphorylation site [posttranslational modification]
335659017069	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
335659017070	ATP binding site [chemical binding]; other site
335659017071	G-X-G motif; other site
335659017072	Response regulator receiver domain; Region: Response_reg; pfam00072
335659017073	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
335659017074	active site
335659017075	phosphorylation site [posttranslational modification]
335659017076	intermolecular recognition site; other site
335659017077	dimerization interface [polypeptide binding]; other site
335659017078	Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109
335659017079	helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347
335659017080	MarR family; Region: MarR_2; pfam12802
335659017081	Acyl-coenzyme A synthetases/AMP-(fatty) acid ligases [Lipid metabolism]; Region: Acs; COG0365
335659017082	Uncharacterized subfamily of medium-chain acyl-CoA synthetase (MACS); Region: MACS_like_3; cd05971
335659017083	active site
335659017084	acyl-activating enzyme (AAE) consensus motif; other site
335659017085	putative CoA binding site [chemical binding]; other site
335659017086	AMP binding site [chemical binding]; other site
335659017087	Epoxide hydrolase N terminus; Region: EHN; pfam06441
335659017088	Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596
335659017089	Yqey-like protein; Region: YqeY; pfam09424
335659017090	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
335659017091	carbamoyl phosphate synthase small subunit; Reviewed; Region: PRK12564
335659017092	Carbamoyl-phosphate synthase small chain, CPSase domain; Region: CPSase_sm_chain; smart01097
335659017093	Small chain of the glutamine-dependent form of carbamoyl phosphate synthase, CPSase II; Region: GATase1_CPSase; cd01744
335659017094	catalytic site [active]
335659017095	subunit interface [polypeptide binding]; other site
335659017096	Uncharacterized protein containing double-stranded beta helix domain [Function unknown]; Region: COG4297
335659017097	Uncharacterized conserved protein [Function unknown]; Region: COG5361
335659017098	Protein of unknown function (DUF1254); Region: DUF1254; pfam06863
335659017099	Protein of unknown function (DUF1214); Region: DUF1214; cl08447
335659017100	DNA-binding ferritin-like protein (oxidative damage protectant) [Inorganic ion transport and metabolism]; Region: Dps; COG0783
335659017101	DPS protein, ferritin-like diiron-binding domain; Region: DPS; cd01043
335659017102	dimerization interface [polypeptide binding]; other site
335659017103	DPS ferroxidase diiron center [ion binding]; other site
335659017104	ion pore; other site
335659017105	Methyltransferase domain; Region: Methyltransf_23; pfam13489
335659017106	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
335659017107	S-adenosylmethionine binding site [chemical binding]; other site
335659017108	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173
335659017109	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
335659017110	dimerization interface [polypeptide binding]; other site
335659017111	putative DNA binding site [nucleotide binding]; other site
335659017112	putative Zn2+ binding site [ion binding]; other site
335659017113	Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814
335659017114	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
335659017115	putative substrate translocation pore; other site
335659017116	carbamoyl phosphate synthase large subunit; Reviewed; Region: carB; PRK05294
335659017117	Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289
335659017118	ATP-grasp domain; Region: ATP-grasp_4; cl17255
335659017119	Carbamoyl-phosphate synthetase large chain, oligomerisation domain; Region: CPSase_L_D3; pfam02787
335659017120	Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289
335659017121	ATP-grasp domain; Region: ATP-grasp_4; cl17255
335659017122	Methylglyoxal synthase-like domain from type II glutamine-dependent carbamoyl phosphate synthetase (CSP). CSP, a CarA and CarB heterodimer, catalyzes the production of carbamoyl phosphate which is subsequently employed in the metabolic pathways...; Region: MGS_CPS_II; cd01424
335659017123	IMP binding site; other site
335659017124	dimer interface [polypeptide binding]; other site
335659017125	interdomain contacts; other site
335659017126	partial ornithine binding site; other site
335659017127	transcription elongation factor GreA; Reviewed; Region: greA; PRK00226
335659017128	Transcription elongation factor, N-terminal; Region: GreA_GreB_N; pfam03449
335659017129	Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272
335659017130	Transcriptional regulators [Transcription]; Region: Lrp; COG1522
335659017131	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
335659017132	putative DNA binding site [nucleotide binding]; other site
335659017133	putative Zn2+ binding site [ion binding]; other site
335659017134	AsnC family; Region: AsnC_trans_reg; pfam01037
335659017135	thioredoxin-disulfide reductase; Region: TRX_reduct; TIGR01292
335659017136	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
335659017137	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
335659017138	Transcriptional regulator [Transcription]; Region: LysR; COG0583
335659017139	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
335659017140	The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422
335659017141	putative effector binding pocket; other site
335659017142	dimerization interface [polypeptide binding]; other site
335659017143	Dihydrodipicolinate synthase (DHDPS); Region: DHDPS; cd00950
335659017144	Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329
335659017145	dimer interface [polypeptide binding]; other site
335659017146	active site
335659017147	catalytic residue [active]
335659017148	ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192
335659017149	ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042
335659017150	P-loop; other site
335659017151	Magnesium ion binding site [ion binding]; other site
335659017152	Predicted permeases [General function prediction only]; Region: COG0679
335659017153	Putative transcription activator [Transcription]; Region: TenA; COG0819
335659017154	Predicted nucleotide-binding protein containing TIR-like domain; Region: TIR-like; cl17861
335659017155	Phasin protein; Region: Phasin_2; cl11491
335659017156	PAS domain; Region: PAS_9; pfam13426
335659017157	PAS domain; Region: PAS_8; pfam13188
335659017158	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
335659017159	PAS domain; Region: PAS_9; pfam13426
335659017160	putative active site [active]
335659017161	heme pocket [chemical binding]; other site
335659017162	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
335659017163	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
335659017164	dimer interface [polypeptide binding]; other site
335659017165	phosphorylation site [posttranslational modification]
335659017166	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
335659017167	ATP binding site [chemical binding]; other site
335659017168	Mg2+ binding site [ion binding]; other site
335659017169	G-X-G motif; other site
335659017170	Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628
335659017171	HAMP domain; Region: HAMP; pfam00672
335659017172	dimerization interface [polypeptide binding]; other site
335659017173	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
335659017174	dimer interface [polypeptide binding]; other site
335659017175	putative CheW interface [polypeptide binding]; other site
335659017176	hypothetical protein; Provisional; Region: PRK06834
335659017177	AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207
335659017178	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
335659017179	FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202
335659017180	putative active site [active]
335659017181	heme pocket [chemical binding]; other site
335659017182	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
335659017183	putative active site [active]
335659017184	heme pocket [chemical binding]; other site
335659017185	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
335659017186	PAS domain; Region: PAS_9; pfam13426
335659017187	putative active site [active]
335659017188	heme pocket [chemical binding]; other site
335659017189	Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283
335659017190	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
335659017191	dimer interface [polypeptide binding]; other site
335659017192	putative CheW interface [polypeptide binding]; other site
335659017193	acetyl-CoA acetyltransferase; Provisional; Region: PRK07108
335659017194	Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751
335659017195	dimer interface [polypeptide binding]; other site
335659017196	active site
335659017197	D-3-phosphoglycerate dehydrogenase; Provisional; Region: PRK13581
335659017198	Phosphoglycerate dehydrogenases, NAD-binding and catalytic domains; Region: PGDH_4; cd12173
335659017199	ligand binding site [chemical binding]; other site
335659017200	NAD binding site [chemical binding]; other site
335659017201	dimerization interface [polypeptide binding]; other site
335659017202	catalytic site [active]
335659017203	C-terminal ACT (regulatory) domain of D-3-phosphoglycerate dehydrogenase (3PGDH); Region: ACT_3PGDH-xct; cd04902
335659017204	putative L-serine binding site [chemical binding]; other site
335659017205	Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cd01494
335659017206	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
335659017207	catalytic residue [active]
335659017208	serC leader as predicted by Rfam v8.1 (RF00517), score 65.51
335659017209	Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673
335659017210	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
335659017211	Coenzyme A binding pocket [chemical binding]; other site
335659017212	Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625
335659017213	GST_N family, unknown subfamily 4; composed of uncharacterized bacterial proteins with similarity to GSTs. GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of...; Region: GST_N_4; cd03056
335659017214	putative C-terminal domain interface [polypeptide binding]; other site
335659017215	putative GSH binding site (G-site) [chemical binding]; other site
335659017216	putative dimer interface [polypeptide binding]; other site
335659017217	C-terminal, alpha helical domain of the Glutathione S-transferase family; Region: GST_C_family; cl02776
335659017218	dimer interface [polypeptide binding]; other site
335659017219	N-terminal domain interface [polypeptide binding]; other site
335659017220	substrate binding pocket (H-site) [chemical binding]; other site
335659017221	Opacity protein and related surface antigens [Cell envelope biogenesis, outer membrane]; Region: COG3637
335659017222	Opacity protein and related surface antigens [Cell envelope biogenesis, outer membrane]; Region: COG3637
335659017223	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
335659017224	Major Facilitator Superfamily; Region: MFS_1; pfam07690
335659017225	putative substrate translocation pore; other site
335659017226	phosphoglucosamine mutase; Provisional; Region: glmM; PRK14315
335659017227	GlmM is a bacterial phosphoglucosamine mutase (PNGM) that belongs to the alpha-D-phosphohexomutase superfamily. It is required for the interconversion of glucosamine-6-phosphate and glucosamine-1-phosphate in the biosynthetic pathway of...; Region: GlmM; cd05802
335659017228	active site
335659017229	substrate binding site [chemical binding]; other site
335659017230	metal binding site [ion binding]; metal-binding site
335659017231	L-lactate dehydrogenase; Provisional; Region: lldD; PRK11197
335659017232	Family of homologous FMN-dependent alpha-hydroxyacid oxidizing enzymes. This family occurs in both prokaryotes and eukaryotes. Members of this family include flavocytochrome b2 (FCB2), glycolate oxidase (GOX), lactate monooxygenase (LMO), mandelate...; Region: alpha_hydroxyacid_oxid_FMN; cd02809
335659017233	active site
335659017234	substrate binding site [chemical binding]; other site
335659017235	FMN binding site [chemical binding]; other site
335659017236	putative catalytic residues [active]
335659017237	Replication protein A, class 2b aminoacyl-tRNA synthetases, and related proteins with oligonucleotide/oligosaccharide (OB) fold; Region: RPA_2b-aaRSs_OBF_like; cl09930
335659017238	generic binding surface II; other site
335659017239	generic binding surface I; other site
335659017240	shikimate 5-dehydrogenase; Reviewed; Region: aroE; PRK00258
335659017241	Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501
335659017242	NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065
335659017243	shikimate binding site; other site
335659017244	NAD(P) binding site [chemical binding]; other site
335659017245	Protein of unknown function (DUF1275); Region: DUF1275; pfam06912
335659017246	Sulfate transporter N-terminal domain with GLY motif; Region: Sulfate_tra_GLY; pfam13792
335659017247	Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659
335659017248	Sulfate transporter family; Region: Sulfate_transp; pfam00916
335659017249	Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function; Region: STAS_SulP_like_sulfate_transporter; cd07042
335659017250	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
335659017251	non-specific DNA binding site [nucleotide binding]; other site
335659017252	salt bridge; other site
335659017253	sequence-specific DNA binding site [nucleotide binding]; other site
335659017254	Elongation factor G (EF-G) family; Region: EF-G_bact; cd04170
335659017255	elongation factor G; Reviewed; Region: PRK12740
335659017256	G1 box; other site
335659017257	putative GEF interaction site [polypeptide binding]; other site
335659017258	GTP/Mg2+ binding site [chemical binding]; other site
335659017259	Switch I region; other site
335659017260	G2 box; other site
335659017261	G3 box; other site
335659017262	Switch II region; other site
335659017263	G4 box; other site
335659017264	G5 box; other site
335659017265	Translation_Factor_II_like: Elongation factor Tu (EF-Tu) domain II-like proteins. Elongation factor Tu consists of three structural domains, this family represents the second domain. Domain II adopts a beta barrel structure and is involved in binding to...; Region: Translation_Factor_II_like; cl02787
335659017266	EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434
335659017267	EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G.  Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713
335659017268	Protein of unknown function (DUF992); Region: DUF992; pfam06186
335659017269	aspartate aminotransferase; Provisional; Region: PRK05764
335659017270	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
335659017271	pyridoxal 5'-phosphate binding site [chemical binding]; other site
335659017272	homodimer interface [polypeptide binding]; other site
335659017273	catalytic residue [active]
335659017274	Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625
335659017275	GST_N family, unknown subfamily 4; composed of uncharacterized bacterial proteins with similarity to GSTs. GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of...; Region: GST_N_4; cd03056
335659017276	putative C-terminal domain interface [polypeptide binding]; other site
335659017277	putative GSH binding site (G-site) [chemical binding]; other site
335659017278	putative dimer interface [polypeptide binding]; other site
335659017279	C-terminal, alpha helical domain of the Glutathione S-transferase family; Region: GST_C_family; cl02776
335659017280	N-terminal domain interface [polypeptide binding]; other site
335659017281	dimer interface [polypeptide binding]; other site
335659017282	substrate binding pocket (H-site) [chemical binding]; other site
335659017283	PAS fold; Region: PAS_7; pfam12860
335659017284	Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673
335659017285	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
335659017286	Coenzyme A binding pocket [chemical binding]; other site
335659017287	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
335659017288	Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248
335659017289	active site
335659017290	catalytic tetrad [active]
335659017291	Uncharacterized enzyme involved in biosynthesis of extracellular polysaccharides [General function prediction only]; Region: COG2329
335659017292	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4102
335659017293	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5267
335659017294	Cysteine-rich CWC; Region: Cys_rich_CWC; pfam14375
335659017295	Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388
335659017296	Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625
335659017297	C-terminal, alpha helical domain of Beta etherase LigE; Region: GST_C_etherase_LigE; cd03202
335659017298	putative N-terminal domain interface [polypeptide binding]; other site
335659017299	putative dimer interface [polypeptide binding]; other site
335659017300	putative substrate binding pocket (H-site) [chemical binding]; other site
335659017301	DNA-binding transcriptional activator GcvA; Provisional; Region: PRK11139
335659017302	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
335659017303	The C-terminal substrate domain of LysR-type GcdR, TrPI, HvR and beta-lactamase regulators, and that of other closely related homologs; contains the type 2 periplasmic binding fold; Region: PBP2_GcdR_TrpI_HvrB_AmpR_like; cd08432
335659017304	dimerization interface [polypeptide binding]; other site
335659017305	substrate binding pocket [chemical binding]; other site
335659017306	excinuclease ABC subunit B; Provisional; Region: PRK05298
335659017307	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
335659017308	ATP binding site [chemical binding]; other site
335659017309	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
335659017310	nucleotide binding region [chemical binding]; other site
335659017311	ATP-binding site [chemical binding]; other site
335659017312	Ultra-violet resistance protein B; Region: UvrB; pfam12344
335659017313	UvrB/uvrC motif; Region: UVR; pfam02151
335659017314	SnoaL-like domain; Region: SnoaL_2; pfam12680
335659017315	Left-handed beta-roll, including virulence factors and various other proteins; Region: LbR-like; cl17507
335659017316	trimer interface [polypeptide binding]; other site
335659017317	SnoaL-like domain; Region: SnoaL_2; pfam12680
335659017318	YdeM is a Bacillus subtilis protein that belongs to a family of prokaryotic proteins of unkown function.  YdeM has sequence similarity to the hot-dog fold of (R)-specific enoyl-CoA hydratase.   Other enzymes with this fold include the peroxisomal...; Region: YdeM; cd03454
335659017319	putative active site [active]
335659017320	putative catalytic site [active]
335659017321	YdeM is a Bacillus subtilis protein that belongs to a family of prokaryotic proteins of unkown function.  YdeM has sequence similarity to the hot-dog fold of (R)-specific enoyl-CoA hydratase.   Other enzymes with this fold include the peroxisomal...; Region: YdeM; cd03454
335659017322	putative active site [active]
335659017323	putative catalytic site [active]
335659017324	Domain of unknown function (DUF4282); Region: DUF4282; pfam14110
335659017325	GTP-binding protein YchF; Reviewed; Region: PRK09601
335659017326	YchF GTPase; Region: YchF; cd01900
335659017327	G1 box; other site
335659017328	GTP/Mg2+ binding site [chemical binding]; other site
335659017329	Switch I region; other site
335659017330	G2 box; other site
335659017331	Switch II region; other site
335659017332	G3 box; other site
335659017333	G4 box; other site
335659017334	G5 box; other site
335659017335	TGS_YchF_C: This subfamily represents TGS domain-containing YchF GTP-binding protein, a universally conserved GTPase whose function is unknown. The N-terminal domain of the YchF protein belongs to the Obg-like family of GTPases, and some members of the...; Region: TGS_YchF_C; cd04867
335659017336	Peptidyl-tRNA hydrolase (PTH) is a monomeric protein that cleaves the ester bond linking the nascent peptide and tRNA when peptidyl-tRNA is released prematurely from the ribosome. This ensures the recycling of peptidyl-tRNAs into tRNAs produced through...; Region: PTH; cd00462
335659017337	putative active site [active]
335659017338	catalytic residue [active]
335659017339	50S ribosomal protein L25/general stress protein Ctc; Reviewed; Region: PRK05618
335659017340	Ribosomal L25/TL5/CTC N-terminal 5S rRNA binding domain; Region: Ribosomal_L25_TL5_CTC; cd00495
335659017341	5S rRNA interface [nucleotide binding]; other site
335659017342	CTC domain interface [polypeptide binding]; other site
335659017343	L16 interface [polypeptide binding]; other site
335659017344	Membrane fusogenic activity; Region: BMFP; pfam04380
335659017345	Dienelactone hydrolase and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG0412
335659017346	prolipoprotein diacylglyceryl transferase; Reviewed; Region: PRK00052
335659017347	Uncharacterized conserved protein [Function unknown]; Region: COG1565
335659017348	Multicopper polyphenol oxidase (laccase) [Secondary metabolites biosynthesis, transport and catabolism]; Region: yfiH; COG1496
335659017349	Multi-copper polyphenol oxidoreductase laccase; Region: Cu-oxidase_4; pfam02578
335659017350	ribose-phosphate pyrophosphokinase; Provisional; Region: PRK01259
335659017351	N-terminal domain of ribose phosphate pyrophosphokinase; Region: Pribosyltran_N; pfam13793
335659017352	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
335659017353	active site
335659017354	Uncharacterized protein conserved in bacteria (DUF2248); Region: DUF2248; pfam10005
335659017355	D-alanine-D-alanine ligase and related ATP-grasp enzymes [Cell envelope biogenesis, outer membrane]; Region: DdlA; COG1181
335659017356	B12 binding domain (B12-BD). Most of the members bind different cobalamid derivates, like B12 (adenosylcobamide) or methylcobalamin or methyl-Co(III) 5-hydroxybenzimidazolylcobamide. This domain is found in several enzymes, such as glutamate mutase; Region: B12-binding_like; cl00293
335659017357	ATP-grasp domain; Region: ATP-grasp_4; cl17255
335659017358	Carbon monoxide dehydrogenase subunit G (CoxG); Region: CoxG; cd05018
335659017359	putative hydrophobic ligand binding site [chemical binding]; other site
335659017360	XdhC and CoxI family; Region: XdhC_CoxI; pfam02625
335659017361	XdhC Rossmann domain; Region: XdhC_C; pfam13478
335659017362	Protein containing von Willebrand factor type A (vWA) domain [General function prediction only]; Region: CoxE; COG3552
335659017363	Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198
335659017364	metal ion-dependent adhesion site (MIDAS); other site
335659017365	ATPases associated with a variety of cellular activities; Region: AAA; smart00382
335659017366	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189
335659017367	Walker A motif; other site
335659017368	ATP binding site [chemical binding]; other site
335659017369	Walker B motif; other site
335659017370	carbon-monoxide dehydrogenase, large subunit; Region: CO_dehy_Mo_lg; TIGR02416
335659017371	Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; smart01008
335659017372	Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738
335659017373	Aerobic-type carbon monoxide dehydrogenase, small subunit CoxS/CutS homologs [Energy production and conversion]; Region: CoxS; COG2080
335659017374	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cl00159
335659017375	catalytic loop [active]
335659017376	iron binding site [ion binding]; other site
335659017377	[2Fe-2S] binding domain; Region: Fer2_2; pfam01799
335659017378	FAD binding domain in molybdopterin dehydrogenase; Region: FAD_binding_5; pfam00941
335659017379	FAD binding domain; Region: FAD_binding_4; pfam01565
335659017380	CO dehydrogenase flavoprotein C-terminal domain; Region: CO_deh_flav_C; pfam03450
335659017381	MHYT domain (predicted integral membrane sensor domain) [Signal transduction mechanisms]; Region: COG3300
335659017382	Bacterial signalling protein N terminal repeat; Region: MHYT; pfam03707
335659017383	Bacterial signalling protein N terminal repeat; Region: MHYT; pfam03707
335659017384	Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms]; Region: LytT; COG3279
335659017385	LytTr DNA-binding domain; Region: LytTR; smart00850
335659017386	riboflavin synthase subunit beta; Provisional; Region: PRK12419
335659017387	active site
335659017388	homopentamer interface [polypeptide binding]; other site
335659017389	flavin mononucleotide (FMN) riboswitch (FMN element) as predicted by Rfam v8.1 (RF00050), score 110.43
335659017390	Putative bacterial sensory transduction regulator; Region: YbjN; cl15834
335659017391	pyrroline-5-carboxylate reductase; Reviewed; Region: PRK11880
335659017392	NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; cl17232
335659017393	Predicted thioesterase [General function prediction only]; Region: COG5496
335659017394	4-Oxalocrotonate Tautomerase:  Catalyzes the isomerization of unsaturated ketones. The structure is a homohexamer that is arranged as a trimer of dimers. The hexamer contains six active sites, each formed by residues from three monomers, two from one...; Region: 4Oxalocrotonate_Tautomerase; cl00235
335659017395	active site 1 [active]
335659017396	dimer interface [polypeptide binding]; other site
335659017397	hexamer interface [polypeptide binding]; other site
335659017398	active site 2 [active]
335659017399	histidyl-tRNA synthetase; Reviewed; Region: hisS; PRK00037
335659017400	Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for...; Region: HisRS-like_core; cd00773
335659017401	dimer interface [polypeptide binding]; other site
335659017402	motif 1; other site
335659017403	motif 2; other site
335659017404	Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA.   PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268
335659017405	active site
335659017406	motif 3; other site
335659017407	HisRS Histidyl-anticodon binding domain. HisRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: HisRS_anticodon; cd00859
335659017408	anticodon binding site; other site
335659017409	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3779
335659017410	Uncharacterized protein conserved in bacteria (DUF2314); Region: DUF2314; pfam10077
335659017411	branched-chain amino acid aminotransferase; Provisional; Region: PRK13357
335659017412	BCAT_beta_family: Branched-chain aminotransferase catalyses the transamination of the branched-chain amino acids  leusine, isoleucine and valine to their respective alpha-keto acids, alpha-ketoisocaproate, alpha-keto-beta-methylvalerate and...; Region: BCAT_beta_family; cd01557
335659017413	homodimer interface [polypeptide binding]; other site
335659017414	substrate-cofactor binding pocket; other site
335659017415	catalytic residue [active]
335659017416	helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347
335659017417	MarR family; Region: MarR_2; pfam12802
335659017418	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
335659017419	heavy metal response regulator; Region: cztR_silR_copR; TIGR01387
335659017420	active site
335659017421	phosphorylation site [posttranslational modification]
335659017422	intermolecular recognition site; other site
335659017423	dimerization interface [polypeptide binding]; other site
335659017424	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
335659017425	DNA binding site [nucleotide binding]
335659017426	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
335659017427	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
335659017428	dimer interface [polypeptide binding]; other site
335659017429	phosphorylation site [posttranslational modification]
335659017430	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
335659017431	ATP binding site [chemical binding]; other site
335659017432	Mg2+ binding site [ion binding]; other site
335659017433	G-X-G motif; other site
335659017434	Protein of unknown function (DUF3617); Region: DUF3617; pfam12276
335659017435	Ribonuclease T2 (RNase T2) is a widespread family of secreted RNases found in every organism examined thus far.  This family includes RNase Rh, RNase MC1, RNase LE, and self-incompatibility RNases (S-RNases).  Plant T2 RNases are expressed during leaf...; Region: RNase_T2_prok; cd01062
335659017436	B1 nucleotide binding pocket [chemical binding]; other site
335659017437	B2 nucleotide binding pocket [chemical binding]; other site
335659017438	CAS motifs; other site
335659017439	active site
335659017440	Protein involved in catabolism of external DNA [General function prediction only]; Region: ComJ; COG2961
335659017441	Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea.  CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458
335659017442	DNA-binding site [nucleotide binding]; DNA binding site
335659017443	RNA-binding motif; other site
335659017444	Opacity protein and related surface antigens [Cell envelope biogenesis, outer membrane]; Region: COG3637
335659017445	excinuclease ABC subunit C; Validated; Region: uvrC; PRK00558
335659017446	Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434
335659017447	GIY-YIG motif/motif A; other site
335659017448	active site
335659017449	catalytic site [active]
335659017450	putative DNA binding site [nucleotide binding]; other site
335659017451	metal binding site [ion binding]; metal-binding site
335659017452	UvrB/uvrC motif; Region: UVR; pfam02151
335659017453	UvrC Helix-hairpin-helix N-terminal; Region: UvrC_HhH_N; pfam08459
335659017454	CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; cl00453
335659017455	Ubiquitin domain of MoaD-like proteins; Region: MoaD; cd00754
335659017456	MoaE interaction surface [polypeptide binding]; other site
335659017457	MoeB interaction surface [polypeptide binding]; other site
335659017458	thiocarboxylated glycine; other site
335659017459	MoaE family. Members of this family are involved in biosynthesis of the molybdenum cofactor (Moco), an essential cofactor for a diverse group of redox enzymes. Moco biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoaE; cd00756
335659017460	MoaE homodimer interface [polypeptide binding]; other site
335659017461	MoaD interaction [polypeptide binding]; other site
335659017462	active site residues [active]
335659017463	HemK family putative methylases; Region: hemK_fam; TIGR00536
335659017464	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
335659017465	S-adenosylmethionine binding site [chemical binding]; other site
335659017466	Virulence factor BrkB; Region: Virul_fac_BrkB; pfam03631
335659017467	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
335659017468	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
335659017469	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
335659017470	DNA binding site [nucleotide binding]
335659017471	Predicted integral membrane protein [Function unknown]; Region: COG5616
335659017472	TPR repeat; Region: TPR_11; pfam13414
335659017473	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
335659017474	TPR motif; other site
335659017475	binding surface
335659017476	TPR repeat; Region: TPR_11; pfam13414
335659017477	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
335659017478	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
335659017479	Haloacid Dehalogenase Superfamily Class (subfamily) IIA; Region: HAD-SF-IIA; TIGR01460
335659017480	active site
335659017481	motif I; other site
335659017482	motif II; other site
335659017483	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
335659017484	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
335659017485	Response regulator receiver domain; Region: Response_reg; pfam00072
335659017486	active site
335659017487	phosphorylation site [posttranslational modification]
335659017488	intermolecular recognition site; other site
335659017489	dimerization interface [polypeptide binding]; other site
335659017490	bifunctional riboflavin kinase/FMN adenylyltransferase; Reviewed; Region: PRK05627
335659017491	FAD synthetase, N-terminal domain of the bifunctional enzyme; Region: FAD_synthetase_N; cd02064
335659017492	active site
335659017493	Riboflavin kinase; Region: Flavokinase; smart00904
335659017494	isoleucyl-tRNA synthetase; Provisional; Region: ileS; PRK13804
335659017495	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
335659017496	active site
335659017497	HIGH motif; other site
335659017498	nucleotide binding site [chemical binding]; other site
335659017499	catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818
335659017500	active site
335659017501	KMSKS motif; other site
335659017502	Anticodon-binding domain of bacterial and eukaryotic mitochondrial isoleucyl tRNA synthetases; Region: Anticodon_Ia_Ile_BEm; cd07960
335659017503	tRNA binding surface [nucleotide binding]; other site
335659017504	anticodon binding site; other site
335659017505	lipoprotein signal peptidase; Provisional; Region: PRK14796
335659017506	lipoprotein signal peptidase; Provisional; Region: PRK14787
335659017507	Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612
335659017508	Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675
335659017509	Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193
335659017510	Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612
335659017511	Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193
335659017512	hypothetical protein; Provisional; Region: PRK09256
335659017513	Protein chain release factor B [Translation, ribosomal structure and biogenesis]; Region: PrfB; COG1186
335659017514	Cytochrome c; Region: Cytochrom_C; cl11414
335659017515	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
335659017516	Glyoxalase I catalyzes the isomerization of the hemithioacetal, formed by a 2-oxoaldehyde and glutathione, to S-D-lactoylglutathione; Region: Glyoxalase_I; cd07233
335659017517	active site
335659017518	dimer interface [polypeptide binding]; other site
335659017519	metal binding site [ion binding]; metal-binding site
335659017520	glutathione binding site [chemical binding]; other site
335659017521	Gluconate 2-dehydrogenase subunit 3; Region: Gluconate_2-dh3; pfam13618
335659017522	Choline dehydrogenase and related flavoproteins [Amino acid transport and metabolism]; Region: BetA; COG2303
335659017523	GMC oxidoreductase; Region: GMC_oxred_C; pfam05199
335659017524	Uncharacterized protein related to arylsulfate sulfotransferase involved in siderophore biosynthesis [General function prediction only]; Region: COG4321
335659017525	DNA mismatch repair protein; Reviewed; Region: mutL; PRK00095
335659017526	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075
335659017527	MutL_Trans: transducer domain, having a ribosomal S5 domain 2-like fold, conserved in the C-terminal domain of DNA mismatch repair (MutL/MLH1/PMS2) family. This transducer domain is homologous to the second domain of the DNA gyrase B subunit, which is...; Region: MutL_Trans; cd00782
335659017528	ATP binding site [chemical binding]; other site
335659017529	MutL C terminal dimerisation domain; Region: MutL_C; pfam08676
335659017530	N6-adenine-specific methylase [DNA replication, recombination, and repair]; Region: COG0742
335659017531	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
335659017532	S-adenosylmethionine binding site [chemical binding]; other site
335659017533	16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187
335659017534	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
335659017535	RNA binding surface [nucleotide binding]; other site
335659017536	Pseudouridine synthases catalyze the isomerization of specific uridines in an RNA molecule to pseudouridines (5-ribosyluracil, psi); Region: PseudoU_synth; cl00130
335659017537	active site
335659017538	Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285
335659017539	nucleoside/Zn binding site; other site
335659017540	dimer interface [polypeptide binding]; other site
335659017541	catalytic motif [active]
335659017542	alpha/beta hydrolase fold; Region: Abhydrolase_1; pfam00561
335659017543	phosphoribosylamine--glycine ligase; Provisional; Region: PRK00885
335659017544	Phosphoribosylglycinamide synthetase, N domain; Region: GARS_N; pfam02844
335659017545	Phosphoribosylglycinamide synthetase, ATP-grasp (A) domain; Region: GARS_A; pfam01071
335659017546	Phosphoribosylglycinamide synthetase, C domain; Region: GARS_C; pfam02843
335659017547	Superfamily I DNA and RNA helicases [DNA replication, recombination, and repair]; Region: UvrD; COG0210
335659017548	Part of AAA domain; Region: AAA_19; pfam13245
335659017549	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
335659017550	Walker A/P-loop; other site
335659017551	ATP binding site [chemical binding]; other site
335659017552	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
335659017553	D-loop; other site
335659017554	H-loop/switch region; other site
335659017555	TOPRIM_OLD: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in bacterial and archaeal nucleases of the OLD (overcome lysogenization defect) family.  The bacteriophage P2 OLD protein, which has DNase as well as...; Region: TOPRIM_OLD; cd01026
335659017556	putative active site [active]
335659017557	putative metal-binding site [ion binding]; other site
335659017558	Winged helix DNA-binding domain; Region: HTH_34; pfam13601
335659017559	Putative lysophospholipase; Region: Hydrolase_4; pfam12146
335659017560	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
335659017561	exodeoxyribonuclease VII large subunit; Reviewed; Region: xseA; PRK00286
335659017562	ExoVII_LU_OBF: A subfamily of OB folds corresponding to the N-terminal OB-fold domain of Escherichia coli exodeoxyribonuclease VII (ExoVII) large subunit. E. coli ExoVII is composed of two non-identical subunits. E. coli ExoVII is a...; Region: ExoVII_LU_OBF; cd04489
335659017563	generic binding surface II; other site
335659017564	generic binding surface I; other site
335659017565	Dienelactone hydrolase and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG0412
335659017566	Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326
335659017567	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3908
335659017568	tetraacyldisaccharide 4'-kinase; Reviewed; Region: lpxK; PRK00652
335659017569	Tetraacyldisaccharide-1-P 4'-kinase [Cell envelope biogenesis, outer membrane]; Region: LpxK; COG1663
335659017570	3-deoxy-D-manno-octulosonic-acid transferase; Reviewed; Region: PRK05749
335659017571	3-Deoxy-D-manno-octulosonic-acid transferase (kdotransferase); Region: Glycos_transf_N; pfam04413
335659017572	Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: DUF374; Region: LPLAT_DUF374-like; cd07983
335659017573	putative acyl-acceptor binding pocket; other site
335659017574	Domain of unknown function (DUF4170); Region: DUF4170; pfam13773
335659017575	Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483
335659017576	CysQ, a 3'-Phosphoadenosine-5'-phosphosulfate (PAPS) 3'-phosphatase, is a bacterial member of the inositol monophosphatase family. It has been proposed that CysQ helps control intracellular levels of PAPS, which is an intermediate in...; Region: CysQ; cd01638
335659017577	active site
335659017578	Predicted Zn-dependent proteases and their inactivated homologs [General function prediction only]; Region: TldD; COG0312
335659017579	4-hydroxybenzoate polyprenyltransferase; Reviewed; Region: ubiA; PRK12878
335659017580	UbiA prenyltransferase family; Region: UbiA; pfam01040
335659017581	16S ribosomal RNA methyltransferase RsmE; Provisional; Region: PRK11713
335659017582	Helix-turn-helix domain; Region: HTH_18; pfam12833
335659017583	ATP phosphoribosyltransferase regulatory subunit; Provisional; Region: hisZ; PRK12295
335659017584	Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA.   PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268
335659017585	motif 1; other site
335659017586	dimer interface [polypeptide binding]; other site
335659017587	active site
335659017588	motif 2; other site
335659017589	Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA.   PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268
335659017590	active site
335659017591	motif 3; other site
335659017592	ATP phosphoribosyltransferase; Reviewed; Region: hisG; PRK00489
335659017593	ATP phosphoribosyltransferase catalytic subunit; Provisional; Region: hisG; PRK13583
335659017594	undecaprenyl phosphate 4-deoxy-4-formamido-L-arabinose transferase; Provisional; Region: PRK10714
335659017595	Bacterial DPM1_like enzymes are related to eukaryotic DPM1; Region: DPM1_like_bac; cd04187
335659017596	Ligand binding site; other site
335659017597	Putative Catalytic site; other site
335659017598	DXD motif; other site
335659017599	uncharacterized YdjC-like family proteins from bacteria; Region: YdjC_like_3; cd10807
335659017600	putative active site [active]
335659017601	YdjC motif; other site
335659017602	Mg binding site [ion binding]; other site
335659017603	putative homodimer interface [polypeptide binding]; other site
335659017604	Uncharacterized protein conserved in bacteria (DUF2076); Region: DUF2076; pfam09849
335659017605	Caspase domain; Region: Peptidase_C14; pfam00656
335659017606	active site
335659017607	substrate pocket [chemical binding]; other site
335659017608	dimer interface [polypeptide binding]; other site
335659017609	proteolytic cleavage site; other site
335659017610	Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376
335659017611	L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734
335659017612	Chemotaxis phosphatase, CheZ; Region: CheZ; cl01219
335659017613	Chaperonin 10 Kd subunit (cpn10 or GroES); Cpn10 cooperates with chaperonin 60 (cpn60 or GroEL), an ATPase, to assist the folding and assembly of proteins and is found in eubacterial cytosol, as well as in the matrix of mitochondria and chloroplasts. It...; Region: cpn10; cd00320
335659017614	oligomerisation interface [polypeptide binding]; other site
335659017615	mobile loop; other site
335659017616	roof hairpin; other site
335659017617	chaperonin GroEL; Reviewed; Region: groEL; PRK12852
335659017618	GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344
335659017619	ring oligomerisation interface [polypeptide binding]; other site
335659017620	ATP/Mg binding site [chemical binding]; other site
335659017621	stacking interactions; other site
335659017622	hinge regions; other site
335659017623	META domain; Region: META; cl01245
335659017624	L-lactate permease; Region: Lactate_perm; cl00701
335659017625	L-lactate permease [Energy production and conversion]; Region: LldP; COG1620
335659017626	ABC transporter transmembrane region 2; Region: ABC_membrane_2; pfam06472
335659017627	ABC-type uncharacterized transport system, permease and ATPase components [General function prediction only]; Region: COG4178
335659017628	ATP-binding cassette domain of peroxisomal transporter, subfamily D; Region: ABCD_peroxisomal_ALDP; cd03223
335659017629	Bacterial protein of unknown function (Gcw_chp); Region: Gcw_chp; cl09901
335659017630	glycolate oxidase iron-sulfur subunit; Provisional; Region: glcF; PRK11274
335659017631	The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655
335659017632	Cysteine-rich domain; Region: CCG; pfam02754
335659017633	Cysteine-rich domain; Region: CCG; pfam02754
335659017634	FAD binding domain; Region: FAD_binding_4; pfam01565
335659017635	glycolate oxidase FAD binding subunit; Provisional; Region: glcE; PRK11282
335659017636	glycolate oxidase subunit GlcD; Provisional; Region: PRK11230
335659017637	FAD binding domain; Region: FAD_binding_4; pfam01565
335659017638	Cytochrome c2 [Energy production and conversion]; Region: COG3474
335659017639	Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596
335659017640	TPR repeat; Region: TPR_11; pfam13414
335659017641	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
335659017642	binding surface
335659017643	TPR motif; other site
335659017644	TPR repeat; Region: TPR_11; pfam13414
335659017645	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cd01292
335659017646	active site
335659017647	HxlR-like helix-turn-helix; Region: HxlR; pfam01638
335659017648	Helix-Turn-Helix DNA binding domain of putative transcription regulators from the MerR superfamily; Region: HTH_MerR-like_sg3; cd01282
335659017649	MerR HTH family regulatory protein; Region: MerR_1; pfam13411
335659017650	DNA binding residues [nucleotide binding]
335659017651	putative dimer interface [polypeptide binding]; other site
335659017652	Medium chain dehydrogenases/reductase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR7; cd08276
335659017653	NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604
335659017654	putative NAD(P) binding site [chemical binding]; other site
335659017655	2-haloalkanoic acid dehalogenase, type II; Region: HAD_type_II; TIGR01428
335659017656	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
335659017657	motif II; other site
335659017658	This CD, composed mainly of bacterial single-domain proteins, includes the Thermus thermophilus (Tt) YbaK-like protein, a homolog of the trans-acting Escherichia coli YbaK Cys-tRNA(Pro) deacylase and the Agrobacterium tumefaciens  ProX Ala-tRNA(Pro)...; Region: ProX_deacylase; cd04333
335659017659	putative deacylase active site [active]
335659017660	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3181
335659017661	Transcriptional regulator [Transcription]; Region: LysR; COG0583
335659017662	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
335659017663	The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422
335659017664	putative effector binding pocket; other site
335659017665	dimerization interface [polypeptide binding]; other site
335659017666	Pirin-related protein [General function prediction only]; Region: COG1741
335659017667	Pirin; Region: Pirin; pfam02678
335659017668	NAD(P)H:quinone oxidoreductase; Provisional; Region: PRK03767
335659017669	NADPH-dependent FMN reductase; Region: FMN_red; pfam03358
335659017670	Protein-L-isoaspartate carboxylmethyltransferase [Posttranslational modification, protein turnover, chaperones]; Region: Pcm; COG2518
335659017671	Methyltransferase domain; Region: Methyltransf_18; pfam12847
335659017672	Protein involved in cellulose biosynthesis (CelD) [Cell envelope biogenesis, outer membrane]; Region: COG5653
335659017673	Acetyltransferase (GNAT) domain; Region: Acetyltransf_6; pfam13480
335659017674	Lipid A core - O-antigen ligase and related enzymes [Cell envelope biogenesis, outer membrane]; Region: RfaL; COG3307
335659017675	O-Antigen ligase; Region: Wzy_C; pfam04932
335659017676	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
335659017677	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013
335659017678	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
335659017679	active site
335659017680	Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641
335659017681	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761
335659017682	active site
335659017683	Glycosyl transferase family group 2; Region: Glyco_trans_2_3; pfam13632
335659017684	Acetyltransferase (isoleucine patch superfamily) [General function prediction only]; Region: WbbJ; COG0110
335659017685	Maltose O-acyltransferase (MAT)-like: This family is composed of maltose O-acetyltransferase, galactoside O-acetyltransferase (GAT), xenobiotic acyltransferase (XAT) and similar proteins. MAT and GAT catalyze the CoA-dependent acetylation of the...; Region: LbH_MAT_like; cd04647
335659017686	trimer interface [polypeptide binding]; other site
335659017687	active site
335659017688	substrate binding site [chemical binding]; other site
335659017689	CoA binding site [chemical binding]; other site
335659017690	Uncharacterized protein involved in exopolysaccharide biosynthesis [Cell envelope biogenesis, outer membrane]; Region: GumC; COG3206
335659017691	Chain length determinant protein; Region: Wzz; pfam02706
335659017692	ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042
335659017693	CobQ/CobB/MinD/ParA nucleotide binding domain; Region: CbiA; pfam01656
335659017694	P-loop; other site
335659017695	Magnesium ion binding site [ion binding]; other site
335659017696	Teichoic acid biosynthesis proteins [Cell envelope biogenesis, outer membrane]; Region: WecG; COG1922
335659017697	The glycosyltransferase WecG/TagA superfamily contains Escherichia coli WecG, Bacillus subtilis TagA and related proteins. E. coli WecG is believed to be a UDP-N-acetyl-D-mannosaminuronic acid transferase, and is involved in enterobacterial common...; Region: Glyco_transf_WecG_TagA; cd06533
335659017698	UDP-glucose 4-epimerase [Cell envelope biogenesis, outer membrane]; Region: GalE; COG1087
335659017699	UDP-glucose 4 epimerase, subgroup 1, extended (e) SDRs; Region: UDP_G4E_1_SDR_e; cd05247
335659017700	NAD binding site [chemical binding]; other site
335659017701	homodimer interface [polypeptide binding]; other site
335659017702	active site
335659017703	substrate binding site [chemical binding]; other site
335659017704	GAF domain; Region: GAF_2; pfam13185
335659017705	GAF domain; Region: GAF_3; pfam13492
335659017706	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
335659017707	GAF domain; Region: GAF; pfam01590
335659017708	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
335659017709	GAF domain; Region: GAF; pfam01590
335659017710	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
335659017711	Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065
335659017712	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
335659017713	GAF domain; Region: GAF; pfam01590
335659017714	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
335659017715	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
335659017716	metal binding site [ion binding]; metal-binding site
335659017717	active site
335659017718	I-site; other site
335659017719	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
335659017720	Malate/L-lactate dehydrogenases [Energy production and conversion]; Region: COG2055
335659017721	FMN-dependent oxidoreductase, nitrilotriacetate monooxygenase family; Region: FMN_nitrolo; TIGR03860
335659017722	nitrilotriacetate monoxygenase oxidizes nitrilotriacetate utilizing reduced flavin mononucleotide (FMNH2) and oxygen. The FMNH2 is provided by an NADH:flavin mononucleotide (FMN) oxidorductase that uses NADH to reduce FMN to FMNH2; Region: Nitrilotriacetate_monoxgenase; cd01095
335659017723	active site
335659017724	non-prolyl cis peptide bond; other site
335659017725	Domain of unknown function (DUF2437); Region: DUF2437; pfam10370
335659017726	4-hydroxyphenylacetate degradation bifunctional isomerase/decarboxylase, C-terminal subunit; Region: HpaG-C-term; TIGR02303
335659017727	Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557
335659017728	Transcriptional regulators [Transcription]; Region: Lrp; COG1522
335659017729	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
335659017730	putative DNA binding site [nucleotide binding]; other site
335659017731	putative Zn2+ binding site [ion binding]; other site
335659017732	AsnC family; Region: AsnC_trans_reg; pfam01037
335659017733	2-oxoacid ferredoxin oxidoreductase; Provisional; Region: PRK13030
335659017734	Pyrimidine (PYR) binding domain of pyruvate ferredoxin oxidoreductase (PFOR), indolepyruvate ferredoxin oxidoreductase alpha subunit (IOR-alpha), and related proteins; Region: TPP_PYR_PFOR_IOR-alpha_like; cd07034
335659017735	dimer interface [polypeptide binding]; other site
335659017736	PYR/PP interface [polypeptide binding]; other site
335659017737	TPP binding site [chemical binding]; other site
335659017738	substrate binding site [chemical binding]; other site
335659017739	Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cl01629
335659017740	TPP-binding site [chemical binding]; other site
335659017741	Pyruvate:ferredoxin oxidoreductase and related 2-oxoacid:ferredoxin oxidoreductases, gamma subunit [Energy production and conversion]; Region: PorG; COG1014
335659017742	indole acetimide hydrolase; Validated; Region: PRK07488
335659017743	Amidase; Region: Amidase; cl11426
335659017744	Transcriptional regulator [Transcription]; Region: LysR; COG0583
335659017745	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
335659017746	The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422
335659017747	putative effector binding pocket; other site
335659017748	dimerization interface [polypeptide binding]; other site
335659017749	efflux pump membrane protein (multidrug resistance protein A); Region: 8a0101; TIGR00998
335659017750	Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849
335659017751	E3 interaction surface; other site
335659017752	lipoyl attachment site [posttranslational modification]; other site
335659017753	HlyD family secretion protein; Region: HlyD_3; pfam13437
335659017754	drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711
335659017755	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
335659017756	putative substrate translocation pore; other site
335659017757	Carboxymuconolactone decarboxylase family; Region: CMD; pfam02627
335659017758	Uncharacterized conserved protein [Function unknown]; Region: COG2128
335659017759	Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115
335659017760	D-Alanine aminotransferase (D-AAT_like): D-amino acid aminotransferase catalyzes transamination between D-amino acids and their respective alpha-keto acids. It plays a major role in the synthesis of bacterial cell wall components like D-alanine and...; Region: D-AAT_like; cd01558
335659017761	homodimer interface [polypeptide binding]; other site
335659017762	substrate-cofactor binding pocket; other site
335659017763	pyridoxal 5'-phosphate binding site [chemical binding]; other site
335659017764	catalytic residue [active]
335659017765	ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126
335659017766	ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262
335659017767	Walker A/P-loop; other site
335659017768	ATP binding site [chemical binding]; other site
335659017769	Q-loop/lid; other site
335659017770	ABC transporter signature motif; other site
335659017771	Walker B; other site
335659017772	D-loop; other site
335659017773	H-loop/switch region; other site
335659017774	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
335659017775	dimer interface [polypeptide binding]; other site
335659017776	conserved gate region; other site
335659017777	putative PBP binding loops; other site
335659017778	ABC-ATPase subunit interface; other site
335659017779	ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215
335659017780	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
335659017781	dimer interface [polypeptide binding]; other site
335659017782	conserved gate region; other site
335659017783	putative PBP binding loops; other site
335659017784	ABC-ATPase subunit interface; other site
335659017785	glutamate and aspartate transporter subunit; Provisional; Region: PRK10797
335659017786	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
335659017787	substrate binding pocket [chemical binding]; other site
335659017788	membrane-bound complex binding site; other site
335659017789	hinge residues; other site
335659017790	hypothetical protein; Provisional; Region: PRK07079
335659017791	Uncharacterized M20 Dipeptidases; Region: M20_dipept_like_2; cd05679
335659017792	metal binding site [ion binding]; metal-binding site
335659017793	putative dimer interface [polypeptide binding]; other site
335659017794	FMN-dependent oxidoreductase, nitrilotriacetate monooxygenase family; Region: FMN_nitrolo; TIGR03860
335659017795	nitrilotriacetate monoxygenase oxidizes nitrilotriacetate utilizing reduced flavin mononucleotide (FMNH2) and oxygen. The FMNH2 is provided by an NADH:flavin mononucleotide (FMN) oxidorductase that uses NADH to reduce FMN to FMNH2; Region: Nitrilotriacetate_monoxgenase; cd01095
335659017796	active site
335659017797	non-prolyl cis peptide bond; other site
335659017798	Thiamine pyrophosphate-requiring enzymes [acetolactate synthase, pyruvate dehydrogenase (cytochrome), glyoxylate carboligase, phosphonopyruvate decarboxylase] [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvB; COG0028
335659017799	Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035
335659017800	PYR/PP interface [polypeptide binding]; other site
335659017801	dimer interface [polypeptide binding]; other site
335659017802	TPP binding site [chemical binding]; other site
335659017803	Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205
335659017804	Thiamine pyrophosphate (TPP) family, BFDC subfamily, TPP-binding module; composed of proteins similar to Pseudomonas putida benzoylformate decarboxylase (BFDC). P. putida BFDC plays a role in the mandelate pathway, catalyzing the conversion of...; Region: TPP_BFDC; cd02002
335659017805	TPP-binding site [chemical binding]; other site
335659017806	dimer interface [polypeptide binding]; other site
335659017807	Glutathione-dependent formaldehyde-activating enzyme; Region: GFA; cl01553
335659017808	NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902
335659017809	Old yellow enzyme (OYE)-like FMN binding domain. OYE was the first flavin-dependent enzyme identified, however its true physiological role remains elusive to this day. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a...; Region: OYE_like_FMN; cd02933
335659017810	FMN binding site [chemical binding]; other site
335659017811	active site
335659017812	substrate binding site [chemical binding]; other site
335659017813	catalytic residue [active]
335659017814	Opacity protein and related surface antigens [Cell envelope biogenesis, outer membrane]; Region: COG3637
335659017815	NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961
335659017816	Aldehyde dehydrogenase family; Region: Aldedh; pfam00171
335659017817	NAD(P) binding site [chemical binding]; other site
335659017818	catalytic residues [active]
335659017819	hypothetical protein; Provisional; Region: PRK06194
335659017820	classical (c) SDRs; Region: SDR_c; cd05233
335659017821	NAD(P) binding site [chemical binding]; other site
335659017822	active site
335659017823	yiaA/B two helix domain; Region: YiaAB; cl01759
335659017824	Phage shock protein A (IM30), suppresses sigma54-dependent transcription [Transcription / Signal transduction mechanisms]; Region: PspA; COG1842
335659017825	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
335659017826	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
335659017827	WHG domain; Region: WHG; pfam13305
335659017828	ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747
335659017829	The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_7; cd08512
335659017830	Beta-glucosidase-related glycosidases [Carbohydrate transport and metabolism]; Region: BglX; COG1472
335659017831	Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; cl07971
335659017832	Domain of unknown function (DUF4173); Region: DUF4173; pfam13777
335659017833	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
335659017834	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
335659017835	active site
335659017836	phosphorylation site [posttranslational modification]
335659017837	intermolecular recognition site; other site
335659017838	dimerization interface [polypeptide binding]; other site
335659017839	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
335659017840	DNA binding site [nucleotide binding]
335659017841	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
335659017842	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
335659017843	dimerization interface [polypeptide binding]; other site
335659017844	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
335659017845	dimer interface [polypeptide binding]; other site
335659017846	phosphorylation site [posttranslational modification]
335659017847	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
335659017848	ATP binding site [chemical binding]; other site
335659017849	Mg2+ binding site [ion binding]; other site
335659017850	G-X-G motif; other site
335659017851	Esterases and lipases (includes fungal lipases, cholinesterases, etc.)  These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312
335659017852	substrate binding pocket [chemical binding]; other site
335659017853	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
335659017854	Protein of unknown function (DUF3365); Region: DUF3365; pfam11845
335659017855	Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114
335659017856	cyclase homology domain; Region: CHD; cd07302
335659017857	nucleotidyl binding site; other site
335659017858	metal binding site [ion binding]; metal-binding site
335659017859	dimer interface [polypeptide binding]; other site
335659017860	Mandelate racemase (MR) catalyzes the Mg2+-dependent 1,1-proton transfer reaction that interconverts the enantiomers of mandelic acid. MR is the first enzyme in the bacterial pathway that converts mandelic acid to benzoic acid and allows this pathway to...; Region: mandelate_racemase; cd03321
335659017861	L-alanine-DL-glutamate epimerase and related enzymes of enolase superfamily [Cell envelope biogenesis, outer membrane / General function prediction only]; Region: COG4948
335659017862	active site
335659017863	This group of proteins belong to a large family of YjgF/YER057c/UK114-like proteins present in bacteria, archaea, and eukaryotes with no definitive function.  The conserved domain is similar in structure to chorismate mutase but there is no sequence...; Region: YjgF_YER057c_UK114_like_1; cd02199
335659017864	homotrimer interaction site [polypeptide binding]; other site
335659017865	putative active site [active]
335659017866	Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_29; cd04688
335659017867	nudix motif; other site
335659017868	Polysaccharide lyase; Region: Polysacc_lyase; pfam14099
335659017869	Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754
335659017870	This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801
335659017871	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
335659017872	Predicted acyltransferases [Lipid metabolism]; Region: COG1835
335659017873	H-NS histone family; Region: Histone_HNS; pfam00816
335659017874	Domain in histone-like proteins of HNS family; Region: HNS; smart00528
335659017875	A sub-family of peptidase C39 which contains Cyclolysin and Hemolysin processing peptidases.  Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the "double-glycine...; Region: Peptidase_C39_likeA; cd02417
335659017876	type I secretion system ABC transporter, HlyB family; Region: type_I_sec_HlyB; TIGR01846
335659017877	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
335659017878	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
335659017879	Walker A/P-loop; other site
335659017880	ATP binding site [chemical binding]; other site
335659017881	Q-loop/lid; other site
335659017882	ABC transporter signature motif; other site
335659017883	Walker B; other site
335659017884	D-loop; other site
335659017885	H-loop/switch region; other site
335659017886	HlyD family secretion protein; Region: HlyD; pfam00529
335659017887	HlyD family secretion protein; Region: HlyD_3; pfam13437
335659017888	Caspase domain; Region: Peptidase_C14; pfam00656
335659017889	Polysaccharide lyase; Region: Polysacc_lyase; pfam14099
335659017890	Tryptophan-rich Synechocystis species C-terminal domain; Region: W_rich_C; pfam07483
335659017891	Tryptophan-rich Synechocystis species C-terminal domain; Region: W_rich_C; pfam07483
335659017892	Tryptophan-rich Synechocystis species C-terminal domain; Region: W_rich_C; pfam07483
335659017893	Chain length determinant protein; Region: Wzz; cl15801
335659017894	exopolysaccharide transport protein family; Region: eps_transp_fam; TIGR01005
335659017895	The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203
335659017896	Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244
335659017897	Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326
335659017898	putative methyltransferase, LIC12133 family; Region: MTase_LIC12133; TIGR04325
335659017899	Platelet-activating factor acetylhydrolase, isoform II; Region: PAF-AH_p_II; pfam03403
335659017900	Condensation domain; Region: Condensation; pfam00668
335659017901	Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020
335659017902	HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745
335659017903	Condensation domain; Region: Condensation; pfam00668
335659017904	HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745
335659017905	Phosphopantetheine attachment site; Region: PP-binding; pfam00550
335659017906	Thioesterase domains of type I polyketide synthases or non-ribosomal peptide synthetases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3319
335659017907	polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833
335659017908	Beta-ketoacyl synthase; Region: PKS_KS; smart00825
335659017909	active site
335659017910	malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128
335659017911	Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827
335659017912	Phosphopantetheine attachment site; Region: PP-binding; pfam00550
335659017913	Glutamate-1-semialdehyde aminotransferase [Coenzyme metabolism]; Region: HemL; COG0001
335659017914	Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321
335659017915	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
335659017916	catalytic residue [active]
335659017917	Condensation domain; Region: Condensation; pfam00668
335659017918	Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020
335659017919	HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745
335659017920	The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930
335659017921	acyl-activating enzyme (AAE) consensus motif; other site
335659017922	AMP binding site [chemical binding]; other site
335659017923	Phosphopantetheine attachment site; Region: PP-binding; pfam00550
335659017924	The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930
335659017925	amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733
335659017926	acyl-activating enzyme (AAE) consensus motif; other site
335659017927	AMP binding site [chemical binding]; other site
335659017928	Phosphopantetheine attachment site; Region: PP-binding; pfam00550
335659017929	Serine acetyltransferase (SAT): SAT catalyzes the CoA-dependent acetylation of the side chain hydroxyl group of L-serine to form O-acetylserine, as the first step of a two-step biosynthetic pathway in bacteria and plants leading to the formation of...; Region: LbH_SAT; cd03354
335659017930	active site
335659017931	substrate binding site [chemical binding]; other site
335659017932	trimer interface [polypeptide binding]; other site
335659017933	CoA binding site [chemical binding]; other site
335659017934	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
335659017935	This family is most closely related to the GT1 family of glycosyltransferases. wbuB in E. coli is involved in the biosynthesis of the O26 O-antigen.  It has been proposed to function as an N-acetyl-L-fucosamine (L-FucNAc) transferase; Region: GT1_wbuB_like; cd03794
335659017936	nucleotide sugar dehydrogenase; Region: NDP-sugDHase; TIGR03026
335659017937	Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912
335659017938	NAD(P) binding site [chemical binding]; other site
335659017939	UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984
335659017940	UDP binding domain; Region: UDPG_MGDP_dh_C; smart00984
335659017941	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
335659017942	This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801
335659017943	Putative catalytic domain of uncharacterized bacterial proteins from the carbohydrate esterase 4 superfamily; Region: CE4_u4; cd10928
335659017944	NodB motif; other site
335659017945	putative active site [active]
335659017946	putative catalytic site [active]
335659017947	putative Zn binding site [ion binding]; other site
335659017948	Polysaccharide lyase; Region: Polysacc_lyase; pfam14099
335659017949	Periplasmic protein involved in polysaccharide export, contains    SLBB domain of b-grasp fold [Cell wall/membrane/envelope biogenesis]; Region: Wza; COG1596
335659017950	Polysaccharide biosynthesis/export protein; Region: Poly_export; pfam02563
335659017951	Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641
335659017952	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
335659017953	active site
335659017954	Polysaccharide lyase; Region: Polysacc_lyase; pfam14099
335659017955	Undecaprenyl-phosphate glucose phosphotransferase; Region: WcaJ_sugtrans; TIGR03023
335659017956	Bacterial sugar transferase; Region: Bac_transf; pfam02397
335659017957	Acetyltransferase (GNAT) domain; Region: Acetyltransf_6; pfam13480
335659017958	Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; Region: MATE_tuaB_like; cd13127
335659017959	Condensation domain; Region: Condensation; pfam00668
335659017960	Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020
335659017961	The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930
335659017962	acyl-activating enzyme (AAE) consensus motif; other site
335659017963	AMP binding site [chemical binding]; other site
335659017964	Phosphopantetheine attachment site; Region: PP-binding; pfam00550
335659017965	Condensation domain; Region: Condensation; pfam00668
335659017966	Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020
335659017967	HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745
335659017968	The adenylation domain of nonribosomal peptide synthetases (NRPS), including salinosporamide A polyketide synthase; Region: A_NRPS_Ta1_like; cd12116
335659017969	acyl-activating enzyme (AAE) consensus motif; other site
335659017970	AMP binding site [chemical binding]; other site
335659017971	Phosphopantetheine attachment site; Region: PP-binding; pfam00550
335659017972	exosortase A system-associated hydrolase 2; Region: hydr2_PEP; TIGR03101
335659017973	exosortase A system-associated hydrolase 1; Region: hydr1_PEP; TIGR03100
335659017974	Protein of unknown function (DUF3530); Region: DUF3530; pfam12048
335659017975	Phosphopantetheinyl transferase component of siderophore synthetase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntD; COG2977
335659017976	Response regulator receiver domain; Region: Response_reg; pfam00072
335659017977	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
335659017978	active site
335659017979	phosphorylation site [posttranslational modification]
335659017980	intermolecular recognition site; other site
335659017981	dimerization interface [polypeptide binding]; other site
335659017982	N-formylglutamate amidohydrolase [Amino acid transport and metabolism]; Region: HutG; COG3741
335659017983	suhB as predicted by Rfam v8.1 (RF00519), score 67.45
335659017984	Predominantly bacterial family of Mg++ dependend phosphatases, related to inositol monophosphatases. These enzymes may dephosphorylate fructose-1,6-bisphosphate, inositol monophospate, 3'-phosphoadenosine-5'-phosphate,  or similar substrates; Region: Bacterial_IMPase_like_1; cd01641
335659017985	Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483
335659017986	active site
335659017987	Tripartite tricarboxylate transporter family receptor; Region: TctC; cl17792
335659017988	Transcriptional regulator [Transcription]; Region: LysR; COG0583
335659017989	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
335659017990	The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator, contains the type 2 periplasmic binding fold; Region: PBP2_LTTR_like_1; cd08421
335659017991	putative dimerization interface [polypeptide binding]; other site
335659017992	Sulfite exporter TauE/SafE; Region: TauE; pfam01925
335659017993	Uncharacterized conserved protein [Function unknown]; Region: COG3791
335659017994	Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280
335659017995	Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114
335659017996	cyclase homology domain; Region: CHD; cd07302
335659017997	nucleotidyl binding site; other site
335659017998	metal binding site [ion binding]; metal-binding site
335659017999	dimer interface [polypeptide binding]; other site
335659018000	Predicted integral membrane protein [Function unknown]; Region: COG5616
335659018001	TPR repeat; Region: TPR_11; pfam13414
335659018002	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
335659018003	binding surface
335659018004	TPR motif; other site
335659018005	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
335659018006	TPR motif; other site
335659018007	binding surface
335659018008	Lysophospholipase [Lipid metabolism]; Region: PldB; COG2267
335659018009	Putative lysophospholipase; Region: Hydrolase_4; pfam12146
335659018010	Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071
335659018011	Alpha-crystallin domain (ACD) found in Escherichia coli inclusion body-associated proteins IbpA and IbpB, and similar proteins.  IbpA and IbpB are 16 kDa small heat shock proteins (sHsps). sHsps are molecular chaperones that suppress protein aggregation...; Region: ACD_IbpA-B_like; cd06470
335659018012	putative dimer interface [polypeptide binding]; other site
335659018013	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
335659018014	Serine hydrolase; Region: Ser_hydrolase; cl17834
335659018015	glutamate synthase subunit alpha; Provisional; Region: gltB; PRK11750
335659018016	Glutamine amidotransferases class-II (Gn-AT), glutamate synthase (GltS)-type. GltS is a homodimer that synthesizes L-glutamate from 2-oxoglutarate and L-glutamine, an important step in ammonia assimilation in bacteria, cyanobacteria and plants. The...; Region: GltS; cd00713
335659018017	active site
335659018018	dimer interface [polypeptide binding]; other site
335659018019	Glutamate synthase central domain; Region: Glu_syn_central; pfam04898
335659018020	Glutamate synthase (GltS) FMN-binding domain.  GltS is a complex iron-sulfur flavoprotein that catalyzes the reductive synthesis of L-glutamate from 2-oxoglutarate and L-glutamine via intramolecular channelling of ammonia, a reaction in the plant, yeast...; Region: GltS_FMN; cd02808
335659018021	active site
335659018022	FMN binding site [chemical binding]; other site
335659018023	substrate binding site [chemical binding]; other site
335659018024	3Fe-4S cluster binding site [ion binding]; other site
335659018025	gltb_C. This domain is found at the C-terminus of the large subunit (gltB) of glutamate synthase (GltS). GltS encodes a complex iron-sulfur flavoprotein that catalyzes the synthesis of L-glutamate from L-glutamine and 2-oxoglutarate. It requires the...; Region: gltB_C; cd00982
335659018026	domain interface; other site
335659018027	glutamate synthase subunit beta; Reviewed; Region: gltD; PRK12810
335659018028	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
335659018029	Uncharacterized protein conserved in bacteria (DUF2320); Region: DUF2320; pfam10082
335659018030	KpsF/GutQ family protein; Region: kpsF; TIGR00393
335659018031	KpsF-like protein. KpsF is an arabinose-5-phosphate isomerase which contains SIS (Sugar ISomerase) domains. SIS domains are found in many phosphosugar isomerases and phosphosugar binding proteins. KpsF catalyzes the reversible reaction of ribulose...; Region: SIS_Kpsf; cd05014
335659018032	putative active site [active]
335659018033	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with KpsF/GutQ domains in the API [A5P (D-arabinose 5-phosphate) isomerase] protein.  These APIs catalyze the conversion of the pentose pathway...; Region: CBS_pair_KpsF_GutQ_assoc; cd04604
335659018034	uncharacterized peroxidase-related enzyme; Region: peroxid_rel; TIGR01926
335659018035	Carboxymuconolactone decarboxylase family; Region: CMD; pfam02627
335659018036	HxlR-like helix-turn-helix; Region: HxlR; pfam01638
335659018037	Membrane protein implicated in regulation of membrane protease activity [Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: COG1585
335659018038	Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330
335659018039	Band_7_stomatin_like: A subgroup of the band 7 domain of flotillin (reggie) like proteins similar to stomatin and podicin (two lipid raft-associated integral membrane proteins). Individual proteins of this band 7 domain family may cluster to form...; Region: Band_7_stomatin_like; cd03403
335659018040	ferrochelatase; Reviewed; Region: hemH; PRK00035
335659018041	Ferrochelatase, N-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_N; cd03411
335659018042	C-terminal domain interface [polypeptide binding]; other site
335659018043	active site
335659018044	Ferrochelatase, C-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_C; cd00419
335659018045	active site
335659018046	N-terminal domain interface [polypeptide binding]; other site
335659018047	MAPEG family; Region: MAPEG; cl09190
335659018048	ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG2215
335659018049	Protein of unknown function (DUF1007); Region: DUF1007; pfam06226
335659018050	Zn-dependent oligopeptidases [Amino acid transport and metabolism]; Region: Dcp; COG0339
335659018051	Peptidase family M3 dipeptidyl carboxypeptidase (DCP); Region: M3A_DCP; cd06456
335659018052	active site
335659018053	Zn binding site [ion binding]; other site
335659018054	speF leader as predicted by Rfam v8.1 (RF00518), score 188.88
335659018055	Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Ornithine Decarboxylase; Region: PLPDE_III_ODC; cd00622
335659018056	dimer interface [polypeptide binding]; other site
335659018057	Diaminopimelate decarboxylase [Amino acid transport and metabolism]; Region: LysA; COG0019
335659018058	active site
335659018059	pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site
335659018060	catalytic residues [active]
335659018061	substrate binding site [chemical binding]; other site
335659018062	Predicted acetyltransferase [General function prediction only]; Region: COG3153
335659018063	This group of proteins belong to a large family of YjgF/YER057c/UK114-like proteins present in bacteria, archaea, and eukaryotes with no definitive function.  The conserved domain is similar in structure to chorismate mutase but there is no sequence...; Region: YjgF_YER057c_UK114_like_6; cd06154
335659018064	homotrimer interaction site [polypeptide binding]; other site
335659018065	putative active site [active]
335659018066	Homospermidine synthase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG5310
335659018067	Saccharopine dehydrogenase; Region: Saccharop_dh; pfam03435
335659018068	Uncharacterized membrane protein [Function unknown]; Region: SapB; COG1285
335659018069	MgtC family; Region: MgtC; pfam02308
335659018070	FOG: WD40 repeat [General function prediction only]; Region: COG2319
335659018071	WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cl02567
335659018072	structural tetrad; other site
335659018073	Putative GTPases (G3E family) [General function prediction only]; Region: COG0523
335659018074	The function of this protein family is unkown. The amino acid sequence of YjiA protein in E. coli contains several conserved motifs that characterizes it as a P-loop GTPase. YijA gene is among the genes significantly induced in response to DNA-damage...; Region: CobW_like; cd03112
335659018075	P-loop, Walker A motif; other site
335659018076	Base recognition motif; other site
335659018077	Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; pfam07683
335659018078	Metal binding protein PsaA.  These proteins have been shown to function as initial receptors in ABC transport of Mn2+ and as surface adhesins in some eubacterial species.  They belong to the TroA superfamily of periplasmic metal binding proteins that...; Region: PsaA; cd01137
335659018079	Periplasmic solute binding protein family; Region: SBP_bac_9; pfam01297
335659018080	metal binding site [ion binding]; metal-binding site
335659018081	ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108
335659018082	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550
335659018083	ABC-ATPase subunit  interface; other site
335659018084	dimer interface [polypeptide binding]; other site
335659018085	putative PBP binding regions; other site
335659018086	ABC-type Mn/Zn transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: ZnuC; COG1121
335659018087	ATP-binding cassette domain of the metal-type transporters; Region: ABC_Metallic_Cations; cd03235
335659018088	Predicted permease; Region: DUF318; cl17795
335659018089	Superoxide dismutase [Inorganic ion transport and metabolism]; Region: SodA; COG0605
335659018090	Iron/manganese superoxide dismutases, alpha-hairpin domain; Region: Sod_Fe_N; pfam00081
335659018091	Iron/manganese superoxide dismutases, C-terminal domain; Region: Sod_Fe_C; pfam02777
335659018092	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182
335659018093	Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; Region: MATE_like_3; cd13148
335659018094	putative efflux protein, MATE family; Region: matE; TIGR00797
335659018095	Uncharacterized protein conserved in bacteria (DUF2147); Region: DUF2147; pfam09917
335659018096	Protein of unknown function (DUF3095); Region: DUF3095; pfam11294
335659018097	3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557
335659018098	classical (c) SDRs; Region: SDR_c; cd05233
335659018099	NAD(P) binding site [chemical binding]; other site
335659018100	active site
335659018101	O-succinylbenzoate-CoA ligase; Region: menE; TIGR01923
335659018102	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
335659018103	acyl-activating enzyme (AAE) consensus motif; other site
335659018104	AMP binding site [chemical binding]; other site
335659018105	active site
335659018106	CoA binding site [chemical binding]; other site
335659018107	Phosphopantetheine attachment site; Region: PP-binding; cl09936
335659018108	long-chain-acyl-CoA synthetase; Validated; Region: PRK08279
335659018109	Fatty acid transport proteins (FATP) play dual roles as fatty acid transporters and its activation enzymes; Region: FATP_FACS; cd05940
335659018110	acyl-activating enzyme (AAE) consensus motif; other site
335659018111	putative AMP binding site [chemical binding]; other site
335659018112	putative active site [active]
335659018113	putative CoA binding site [chemical binding]; other site
335659018114	Tripartite tricarboxylate transporter family receptor; Region: TctC; cl17792
335659018115	Protein of unknown function (DUF3551); Region: DUF3551; pfam12071
335659018116	Protein of unknown function (DUF3551); Region: DUF3551; pfam12071
335659018117	heat shock protein 90; Provisional; Region: PRK05218
335659018118	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
335659018119	ATP binding site [chemical binding]; other site
335659018120	Mg2+ binding site [ion binding]; other site
335659018121	G-X-G motif; other site
335659018122	SnoaL-like domain; Region: SnoaL_4; pfam13577
335659018123	two-component response regulator; Provisional; Region: PRK09191
335659018124	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
335659018125	active site
335659018126	phosphorylation site [posttranslational modification]
335659018127	intermolecular recognition site; other site
335659018128	dimerization interface [polypeptide binding]; other site
335659018129	RNA polymerase sigma factor; Provisional; Region: PRK12540
335659018130	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
335659018131	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
335659018132	DNA binding residues [nucleotide binding]
335659018133	Nitroreductase family. Members of this family utilize FMN as a cofactor and catalyze reduction of a variety of nitroaromatic compounds, including nitrofurans, nitrobenzens, nitrophenol, nitrobenzoate and quinones by using either NADH or NADPH as a source...; Region: Nitroreductase; cd02136
335659018134	putative FMN binding site [chemical binding]; other site
335659018135	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
335659018136	Putative acyl-CoA dehydrogenases similar to fadE6, fadE17, and fadE26; Region: ACAD_fadE6_17_26; cd01152
335659018137	FAD binding site [chemical binding]; other site
335659018138	substrate binding site [chemical binding]; other site
335659018139	catalytic base [active]
335659018140	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
335659018141	Putative acyl-CoA dehydrogenases similar to fadE6, fadE17, and fadE26; Region: ACAD_fadE6_17_26; cd01152
335659018142	FAD binding site [chemical binding]; other site
335659018143	substrate binding site [chemical binding]; other site
335659018144	catalytic base [active]
335659018145	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
335659018146	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
335659018147	active site
335659018148	acyl-CoA synthetase; Provisional; Region: PRK12582
335659018149	Feruloyl-CoA synthetase (FCS); Region: FCS; cd05921
335659018150	acyl-activating enzyme (AAE) consensus motif; other site
335659018151	putative AMP binding site [chemical binding]; other site
335659018152	putative active site [active]
335659018153	putative CoA binding site [chemical binding]; other site
335659018154	Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024
335659018155	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
335659018156	substrate binding site [chemical binding]; other site
335659018157	oxyanion hole (OAH) forming residues; other site
335659018158	trimer interface [polypeptide binding]; other site
335659018159	3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK08217
335659018160	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
335659018161	NAD(P) binding site [chemical binding]; other site
335659018162	active site
335659018163	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
335659018164	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
335659018165	acetyl-CoA acetyltransferase; Provisional; Region: PRK06504
335659018166	Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751
335659018167	dimer interface [polypeptide binding]; other site
335659018168	active site
335659018169	long-chain-fatty-acid--CoA ligase; Validated; Region: PRK08276
335659018170	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
335659018171	Bacterial Bile acid CoA ligases and similar proteins; Region: BACL_like; cd05929
335659018172	acyl-activating enzyme (AAE) consensus motif; other site
335659018173	acyl-activating enzyme (AAE) consensus motif; other site
335659018174	putative AMP binding site [chemical binding]; other site
335659018175	putative active site [active]
335659018176	putative CoA binding site [chemical binding]; other site
335659018177	Methylated DNA-protein cysteine methyltransferase [DNA replication, recombination, and repair]; Region: Ada; COG0350
335659018178	The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445
335659018179	DNA binding site [nucleotide binding]
335659018180	active site
335659018181	Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596
335659018182	Novel bacterial esterase that cleaves esters on halogenated cyclic compounds; Region: Esterase_713_like; cl17303
335659018183	catalytic site [active]
335659018184	Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596
335659018185	Novel bacterial esterase that cleaves esters on halogenated cyclic compounds; Region: Esterase_713_like; cl17303
335659018186	catalytic site [active]
335659018187	Transcriptional regulators [Transcription]; Region: GntR; COG1802
335659018188	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
335659018189	DNA-binding site [nucleotide binding]; DNA binding site
335659018190	FCD domain; Region: FCD; pfam07729
335659018191	Phytanoyl-CoA dioxygenase (PhyH); Region: PhyH; cl17312
335659018192	Predicted homoserine dehydrogenase [Amino acid transport and metabolism]; Region: COG4091
335659018193	Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912
335659018194	NAD(P) binding site [chemical binding]; other site
335659018195	SAF domain of putative dehydrogenases or oxidoreductases; Region: SAF_DH_OX_like; cd11616
335659018196	TRAP-type mannitol/chloroaromatic compound transport system, periplasmic component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: FcbT1; COG4663
335659018197	Bacterial extracellular solute-binding protein, family 7; Region: SBP_bac_7; cl15441
335659018198	TRAP-type mannitol/chloroaromatic compound transport system, periplasmic component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: FcbT1; COG4663
335659018199	Bacterial extracellular solute-binding protein, family 7; Region: SBP_bac_7; cl15441
335659018200	potential protein location (hypothetical protein S23_63820 [Bradyrhizobium sp. S23321]) that overlaps RNA (23S ribosomal RNA)
335659018201	potential protein location (hypothetical protein S23_63860 [Bradyrhizobium sp. S23321]) that overlaps RNA (16S ribosomal RNA)
335659018202	Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739
335659018203	Peptidase family M23; Region: Peptidase_M23; pfam01551
335659018204	ATP-dependent chaperone ClpB; Region: chaperone_ClpB; TIGR03346
335659018205	Clp amino terminal domain; Region: Clp_N; pfam02861
335659018206	Clp amino terminal domain; Region: Clp_N; pfam02861
335659018207	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
335659018208	Walker A motif; other site
335659018209	ATP binding site [chemical binding]; other site
335659018210	Walker B motif; other site
335659018211	arginine finger; other site
335659018212	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
335659018213	Walker A motif; other site
335659018214	ATP binding site [chemical binding]; other site
335659018215	Walker B motif; other site
335659018216	C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431
335659018217	Uncharacterized Fe-S protein [General function prediction only]; Region: COG3217
335659018218	MOSC N-terminal beta barrel domain; Region: MOSC_N; pfam03476
335659018219	MOSC domain; Region: MOSC; pfam03473
335659018220	TIGR02594 family protein; Region: TIGR02594
335659018221	Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596
335659018222	Methyltransferase domain; Region: Methyltransf_23; pfam13489
335659018223	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
335659018224	S-adenosylmethionine binding site [chemical binding]; other site
335659018225	homoserine O-acetyltransferase; Provisional; Region: metX; PRK00175
335659018226	homoserine O-acetyltransferase; Region: homoserO_Ac_trn; TIGR01392
335659018227	S-adenosylmethionine (SAM) riboswitch (alpha-proteobacteria) as predicted by Rfam v8.1 (RF00521), score 79.68
335659018228	hypothetical protein; Provisional; Region: PRK06034
335659018229	Chorismate mutase type II; Region: CM_2; pfam01817
335659018230	histidinol-phosphate aminotransferase; Validated; Region: PRK02731
335659018231	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
335659018232	pyridoxal 5'-phosphate binding site [chemical binding]; other site
335659018233	homodimer interface [polypeptide binding]; other site
335659018234	catalytic residue [active]
335659018235	cyclohexadienyl dehydrogenase; Validated; Region: PRK07502
335659018236	prephenate dehydrogenase; Validated; Region: PRK08507
335659018237	Uncharacterized protein conserved in bacteria (DUF2125); Region: DUF2125; pfam09898
335659018238	Uncharacterized protein involved in cation transport [Inorganic ion transport and metabolism]; Region: ChaC; COG3703
335659018239	GGCT-like domains, also called AIG2-like family. Gamma-glutamyl cyclotransferase (GGCT) catalyzes the formation of pyroglutamic acid (5-oxoproline) from dipeptides containing gamma-glutamyl, and is a dimeric protein. In Homo sapiens, the protein is...; Region: GGCT_like; cd06661
335659018240	putative active site pocket [active]
335659018241	dimerization interface [polypeptide binding]; other site
335659018242	putative catalytic residue [active]
335659018243	1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204
335659018244	Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989
335659018245	putative acyl-acceptor binding pocket; other site
335659018246	Uncharacterized conserved protein [Function unknown]; Region: COG1434
335659018247	YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259
335659018248	putative active site [active]
335659018249	Cell division protein [Cell division and chromosome partitioning]; Region: FtsX; COG2177
335659018250	cell division ABC transporter subunit FtsX; Provisional; Region: ftsX; PRK11026
335659018251	Predicted ATPase involved in cell division [Cell division and chromosome partitioning]; Region: FtsE; COG2884
335659018252	ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255
335659018253	Walker A/P-loop; other site
335659018254	ATP binding site [chemical binding]; other site
335659018255	Q-loop/lid; other site
335659018256	ABC transporter signature motif; other site
335659018257	Walker B; other site
335659018258	D-loop; other site
335659018259	H-loop/switch region; other site
335659018260	MJ0042 family finger-like domain; Region: MJ0042_CXXC; TIGR02098
335659018261	Protein of unknown function (DUF3426); Region: DUF3426; pfam11906
335659018262	Intracellular proteinase inhibitor; Region: BsuPI; pfam12690
335659018263	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
335659018264	Response regulator receiver domain; Region: Response_reg; pfam00072
335659018265	active site
335659018266	phosphorylation site [posttranslational modification]
335659018267	intermolecular recognition site; other site
335659018268	dimerization interface [polypeptide binding]; other site
335659018269	Domain of unknown function (DUF4175); Region: DUF4175; pfam13779
335659018270	Domain of unknown function (DUF4175); Region: DUF4175; pfam13779
335659018271	Succinate:quinone oxidoreductase (SQR) and Quinol:fumarate reductase (QFR) family, transmembrane subunits; SQR catalyzes the oxidation of succinate to fumarate coupled to the reduction of quinone to quinol, while QFR catalyzes the reverse reaction. SQR; Region: SQR_QFR_TM; cl00881
335659018272	Carboxymuconolactone decarboxylase family; Region: CMD; cl00460
335659018273	3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084
335659018274	6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599
335659018275	diaminopimelate decarboxylase; Region: lysA; TIGR01048
335659018276	Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Diaminopimelate Decarboxylase; Region: PLPDE_III_DapDC; cd06828
335659018277	active site
335659018278	pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site
335659018279	substrate binding site [chemical binding]; other site
335659018280	catalytic residues [active]
335659018281	dimer interface [polypeptide binding]; other site
335659018282	Prokaryotic lipoprotein-attachment site; Region: LPAM_2; pfam13627
335659018283	argininosuccinate lyase; Provisional; Region: PRK00855
335659018284	Argininosuccinate lyase (argininosuccinase, ASAL); Region: Argininosuccinate_lyase; cd01359
335659018285	active sites [active]
335659018286	tetramer interface [polypeptide binding]; other site
335659018287	TlpA-like family; composed of  TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966
335659018288	Thioredoxin-like; Region: Thioredoxin_8; pfam13905
335659018289	catalytic residues [active]
335659018290	3-hydroxybutyryl-CoA dehydrogenase; Validated; Region: PRK07530
335659018291	3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737
335659018292	3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725
335659018293	Electron transfer flavoprotein, alpha subunit [Energy production and conversion]; Region: FixB; COG2025
335659018294	The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_alpha; cd01715
335659018295	Electron transfer flavoprotein FAD-binding domain; Region: ETF_alpha; pfam00766
335659018296	The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_beta; cd01714
335659018297	Ligand binding site [chemical binding]; other site
335659018298	Electron transfer flavoprotein domain; Region: ETF; pfam01012
335659018299	cob(I)alamin adenosyltransferase [Coenzyme transport and    metabolism]; Region: COG2096
335659018300	Hypoxia induced protein conserved region; Region: HIG_1_N; pfam04588
335659018301	Virulence factor BrkB; Region: Virul_fac_BrkB; pfam03631
335659018302	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
335659018303	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
335659018304	dimer interface [polypeptide binding]; other site
335659018305	phosphorylation site [posttranslational modification]
335659018306	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
335659018307	ATP binding site [chemical binding]; other site
335659018308	Mg2+ binding site [ion binding]; other site
335659018309	G-X-G motif; other site
335659018310	Response regulator receiver domain; Region: Response_reg; pfam00072
335659018311	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
335659018312	active site
335659018313	phosphorylation site [posttranslational modification]
335659018314	intermolecular recognition site; other site
335659018315	dimerization interface [polypeptide binding]; other site
335659018316	glutamyl-Q tRNA(Asp) synthetase; Reviewed; Region: PRK05710
335659018317	tRNA synthetases class I (E and Q), catalytic domain; Region: tRNA-synt_1c; pfam00749
335659018318	active site
335659018319	HIGH motif; other site
335659018320	nucleotide binding site [chemical binding]; other site
335659018321	active site
335659018322	KMSKS motif; other site
335659018323	endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056
335659018324	endonuclease III; Region: ENDO3c; smart00478
335659018325	minor groove reading motif; other site
335659018326	helix-hairpin-helix signature motif; other site
335659018327	substrate binding pocket [chemical binding]; other site
335659018328	active site
335659018329	Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072
335659018330	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
335659018331	SdiA-regulated; Region: SdiA-regulated; cd09971
335659018332	NHL repeat; Region: NHL; pfam01436
335659018333	Restriction endonuclease [Defense mechanisms]; Region: McrA; COG1403
335659018334	HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085
335659018335	active site
335659018336	Laminarinase, member of the glycosyl hydrolase family 16; Region: GH16_laminarinase_like; cd08023
335659018337	active site
335659018338	catalytic residues [active]
335659018339	Protein of unknown function (DUF2029); Region: DUF2029; pfam09594
335659018340	Dodecin; Region: Dodecin; pfam07311
335659018341	Autotransporter beta-domain; Region: Autotransporter; smart00869
335659018342	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
335659018343	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
335659018344	dipeptide transporter ATP-binding subunit; Provisional; Region: dppF; PRK11308
335659018345	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
335659018346	Walker A/P-loop; other site
335659018347	ATP binding site [chemical binding]; other site
335659018348	Q-loop/lid; other site
335659018349	ABC transporter signature motif; other site
335659018350	Walker B; other site
335659018351	D-loop; other site
335659018352	H-loop/switch region; other site
335659018353	oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727
335659018354	ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444
335659018355	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
335659018356	Walker A/P-loop; other site
335659018357	ATP binding site [chemical binding]; other site
335659018358	Q-loop/lid; other site
335659018359	ABC transporter signature motif; other site
335659018360	Walker B; other site
335659018361	D-loop; other site
335659018362	H-loop/switch region; other site
335659018363	oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727
335659018364	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173
335659018365	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
335659018366	dimer interface [polypeptide binding]; other site
335659018367	conserved gate region; other site
335659018368	putative PBP binding loops; other site
335659018369	ABC-ATPase subunit interface; other site
335659018370	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601
335659018371	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
335659018372	dimer interface [polypeptide binding]; other site
335659018373	conserved gate region; other site
335659018374	putative PBP binding loops; other site
335659018375	ABC-ATPase subunit interface; other site
335659018376	ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747
335659018377	The substrate-binding component of ABC-type thermophilic oligopeptide-binding protein Hb8-like import systems, contains the type 2 periplasmic binding fold; Region: PBP2_thermophilic_Hb8_like; cd08513
335659018378	peptide binding site [polypeptide binding]; other site
335659018379	dimer interface [polypeptide binding]; other site
335659018380	M20 Peptidase Aminoacylase 1-like protein 2 aminobenzoyl-glutamate utilization protein B subfamily; Region: M20_Acy1L2_AbgB; cd05673
335659018381	Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473
335659018382	putative metal binding site [ion binding]; other site
335659018383	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]; Region: DegQ; COG0265
335659018384	Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365
335659018385	PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987
335659018386	protein binding site [polypeptide binding]; other site
335659018387	Predicted esterase [General function prediction only]; Region: COG0400
335659018388	DsbA family, Com1-like subfamily; composed of proteins similar to Com1, a 27-kDa outer membrane-associated immunoreactive protein originally found in both acute and chronic disease strains of the pathogenic bacteria Coxiella burnetti. It contains a CXXC...; Region: DsbA_Com1_like; cd03023
335659018389	DSBA-like thioredoxin domain; Region: DSBA; pfam01323
335659018390	catalytic residues [active]
335659018391	LrgB-like family; Region: LrgB; pfam04172
335659018392	LrgA family; Region: LrgA; pfam03788
335659018393	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
335659018394	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
335659018395	Putative ammonia monooxygenase [General function prediction only]; Region: AbrB; COG3180
335659018396	membrane protein AbrB duplication; Region: Gneg_AbrB_dup; TIGR03082
335659018397	membrane protein AbrB duplication; Region: Gneg_AbrB_dup; TIGR03082
335659018398	Disulfide bond formation protein DsbB; Region: DsbB; pfam02600
335659018399	4-hydroxybenzoate polyprenyltransferase and related prenyltransferases [Coenzyme metabolism]; Region: UbiA; cl00337
335659018400	GtrA-like protein; Region: GtrA; pfam04138
335659018401	Predicted acyltransferases [Lipid metabolism]; Region: COG1835
335659018402	Uncharacterized conserved protein (DUF2235); Region: DUF2235; pfam09994
335659018403	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
335659018404	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
335659018405	active site
335659018406	phosphorylation site [posttranslational modification]
335659018407	intermolecular recognition site; other site
335659018408	dimerization interface [polypeptide binding]; other site
335659018409	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
335659018410	DNA binding residues [nucleotide binding]
335659018411	dimerization interface [polypeptide binding]; other site
335659018412	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585
335659018413	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
335659018414	ATP binding site [chemical binding]; other site
335659018415	Mg2+ binding site [ion binding]; other site
335659018416	G-X-G motif; other site
335659018417	Cysteine rich repeat; Region: Cys_rich_FGFR; pfam00839
335659018418	choline dehydrogenase; Validated; Region: PRK02106
335659018419	GMC oxidoreductase; Region: GMC_oxred_C; pfam05199
335659018420	Nitronate monooxygenase; Region: NMO; pfam03060
335659018421	2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730
335659018422	FMN binding site [chemical binding]; other site
335659018423	substrate binding site [chemical binding]; other site
335659018424	putative catalytic residue [active]
335659018425	acyl-CoA synthetase; Validated; Region: PRK06188
335659018426	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
335659018427	Bacterial Bile acid CoA ligases and similar proteins; Region: BACL_like; cd05929
335659018428	acyl-activating enzyme (AAE) consensus motif; other site
335659018429	acyl-activating enzyme (AAE) consensus motif; other site
335659018430	putative AMP binding site [chemical binding]; other site
335659018431	putative active site [active]
335659018432	putative CoA binding site [chemical binding]; other site
335659018433	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
335659018434	PAS fold; Region: PAS_3; pfam08447
335659018435	putative active site [active]
335659018436	heme pocket [chemical binding]; other site
335659018437	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
335659018438	dimer interface [polypeptide binding]; other site
335659018439	phosphorylation site [posttranslational modification]
335659018440	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
335659018441	ATP binding site [chemical binding]; other site
335659018442	G-X-G motif; other site
335659018443	Response regulator receiver domain; Region: Response_reg; pfam00072
335659018444	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
335659018445	active site
335659018446	phosphorylation site [posttranslational modification]
335659018447	intermolecular recognition site; other site
335659018448	dimerization interface [polypeptide binding]; other site
335659018449	circadian clock protein KaiC; Reviewed; Region: PRK09302
335659018450	RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233
335659018451	Walker A motif; other site
335659018452	ATP binding site [chemical binding]; other site
335659018453	Walker B motif; other site
335659018454	recA bacterial DNA recombination protein; Region: RecA; cl17211
335659018455	RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233
335659018456	Walker A motif; other site
335659018457	ATP binding site [chemical binding]; other site
335659018458	Walker B motif; other site
335659018459	Thioesterase-like superfamily; Region: 4HBT_3; pfam13622
335659018460	Dioxygenases related to 2-nitropropane dioxygenase [General function prediction only]; Region: COG2070
335659018461	2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730
335659018462	FMN binding site [chemical binding]; other site
335659018463	substrate binding site [chemical binding]; other site
335659018464	putative catalytic residue [active]
335659018465	aspartate ammonia-lyase; Provisional; Region: aspA; PRK12273
335659018466	Aspartase; Region: Aspartase; cd01357
335659018467	active sites [active]
335659018468	tetramer interface [polypeptide binding]; other site
335659018469	Predicted membrane protein [Function unknown]; Region: COG1238
335659018470	Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in Escherichia coli phosphoribosyl-ATP pyrophosphohydrolase (HisIE or PRATP-PH) and its homologs; Region: NTP-PPase_HisIE_like; cd11534
335659018471	metal binding site [ion binding]; metal-binding site
335659018472	NMT1/THI5 like; Region: NMT1; pfam09084
335659018473	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cl17432
335659018474	membrane-bound complex binding site; other site
335659018475	hinge residues; other site
335659018476	cyclic beta-1,2-glucan ABC transporter; Provisional; Region: PRK13657
335659018477	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
335659018478	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
335659018479	Walker A/P-loop; other site
335659018480	ATP binding site [chemical binding]; other site
335659018481	Q-loop/lid; other site
335659018482	ABC transporter signature motif; other site
335659018483	Walker B; other site
335659018484	D-loop; other site
335659018485	H-loop/switch region; other site
335659018486	D-alanyl-D-alanine carboxypeptidase; Region: Peptidase_S11; pfam00768
335659018487	Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872
335659018488	Long-chain-fatty-acid--CoA ligase; Validated; Region: PRK07059
335659018489	Prokaryotic long-chain fatty acid CoA synthetases similar to Escherichia coli FadD; Region: FC-FACS_FadD_like; cd05936
335659018490	acyl-activating enzyme (AAE) consensus motif; other site
335659018491	putative AMP binding site [chemical binding]; other site
335659018492	putative active site [active]
335659018493	putative CoA binding site [chemical binding]; other site
335659018494	Bacterial protein of unknown function (DUF924); Region: DUF924; pfam06041
335659018495	Peroxiredoxin (PRX) family, PRX5-like subfamily; members are similar to the human protein, PRX5, a homodimeric TRX peroxidase, widely expressed in tissues and found cellularly in mitochondria, peroxisomes and the cytosol. The cellular location of PRX5...; Region: PRX5_like; cd03013
335659018496	catalytic triad [active]
335659018497	dimer interface [polypeptide binding]; other site
335659018498	RNase HI family found mainly in prokaryotes; Region: RNase_HI_prokaryote_like; cd09278
335659018499	RNA/DNA hybrid binding site [nucleotide binding]; other site
335659018500	active site
335659018501	Putative homoserine kinase type II (protein kinase fold) [General function prediction only]; Region: COG2334
335659018502	Homoserine Kinase, type II. Homoserine kinase is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs), RIO kinases, actin-fragmin kinase (AFK), and...; Region: HomoserineK_II; cd05153
335659018503	putative active site [active]
335659018504	putative substrate binding site [chemical binding]; other site
335659018505	ATP binding site [chemical binding]; other site
335659018506	4-Hydroxy-3-methylbut-2-enyl diphosphate reductase IspH [Lipid metabolism]; Region: lytB; COG0761
335659018507	4-hydroxy-3-methylbut-2-enyl diphosphate reductase; Reviewed; Region: ispH; PRK01045
335659018508	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3820
335659018509	Outer membrane protein W [Cell envelope biogenesis, outer membrane]; Region: OmpW; COG3047
335659018510	propionyl-CoA synthetase; Provisional; Region: prpE; PRK10524
335659018511	Propionyl-CoA synthetase (PrpE); Region: PrpE; cd05967
335659018512	acyl-activating enzyme (AAE) consensus motif; other site
335659018513	putative AMP binding site [chemical binding]; other site
335659018514	putative active site [active]
335659018515	putative CoA binding site [chemical binding]; other site
335659018516	FOG: TPR repeat [General function prediction only]; Region: NrfG; COG0457
335659018517	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
335659018518	binding surface
335659018519	TPR motif; other site
335659018520	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
335659018521	binding surface
335659018522	TPR motif; other site
335659018523	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
335659018524	binding surface
335659018525	TPR motif; other site
335659018526	Protein of unknown function (DUF1311); Region: DUF1311; pfam07007
335659018527	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
335659018528	TPR motif; other site
335659018529	TPR repeat; Region: TPR_11; pfam13414
335659018530	binding surface
335659018531	Protein of unknown function (DUF1311); Region: DUF1311; cl01530
335659018532	Na+/H+ antiporter, bacterial form; Region: a_cpa1; TIGR00831
335659018533	3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK07231
335659018534	classical (c) SDRs; Region: SDR_c; cd05233
335659018535	NAD(P) binding site [chemical binding]; other site
335659018536	active site
335659018537	Domain of unknown function (DUF1850); Region: DUF1850; pfam08905
335659018538	TRAP transporter, 4TM/12TM fusion protein; Region: TRAP_fused; TIGR02123
335659018539	DctM-like transporters; Region: DctM; pfam06808
335659018540	TRAP-type uncharacterized transport system, periplasmic component [General function prediction only]; Region: Imp; COG2358
335659018541	TRAP transporter solute receptor, TAXI family; Region: TRAP_TAXI; TIGR02122
335659018542	Coenzyme A pyrophosphatase (CoAse), a member of the Nudix hydrolase superfamily, functions to catalyze the elimination of oxidized inactive CoA, which can inhibit CoA-utilizing enzymes. The need of CoAses mainly arises under conditions of oxidative...; Region: CoAse; cd03426
335659018543	putative active site [active]
335659018544	putative CoA binding site [chemical binding]; other site
335659018545	nudix motif; other site
335659018546	metal binding site [ion binding]; metal-binding site
335659018547	PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria.  Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443
335659018548	CoenzymeA binding site [chemical binding]; other site
335659018549	subunit interaction site [polypeptide binding]; other site
335659018550	PHB binding site; other site
335659018551	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
335659018552	Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248
335659018553	active site
335659018554	catalytic tetrad [active]
335659018555	StaR_like; a well-conserved protein found in bacteria, plants, and animals. A family member from Streptomyces toyocaensis, StaR is part of a gene cluster involved in the biosynthesis of glycopeptide antibiotics (GPAs), specifically A47934. It has been...; Region: StaR_like; cd05804
335659018556	myosin-cross-reactive antigen; Provisional; Region: PRK13977
335659018557	Long-chain acyl-CoA synthetases (AMP-forming) [Lipid metabolism]; Region: FAA1; COG1022
335659018558	Long-chain fatty acid CoA synthetases and Bubblegum-like very long-chain fatty acid CoA synthetases; Region: VL_LC_FACS_like; cd05907
335659018559	acyl-activating enzyme (AAE) consensus motif; other site
335659018560	putative AMP binding site [chemical binding]; other site
335659018561	putative active site [active]
335659018562	putative CoA binding site [chemical binding]; other site
335659018563	Isochorismatase family; Region: Isochorismatase; pfam00857
335659018564	Nicotinamidase_ related amidohydrolases.  Cysteine hydrolases of unknown function that share the catalytic triad with other amidohydrolases, like nicotinamidase, which converts nicotinamide to nicotinic acid and ammonia; Region: nicotinamidase_related; cd01014
335659018565	catalytic triad [active]
335659018566	conserved cis-peptide bond; other site
335659018567	Flavin containing amine oxidoreductase; Region: Amino_oxidase; pfam01593
335659018568	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
335659018569	Pyrimidine reductase, riboflavin biosynthesis [Coenzyme metabolism]; Region: RibD; COG1985
335659018570	RibD C-terminal domain; Region: RibD_C; cl17279
335659018571	nitrobindin heme-binding domain; Region: nitrobindin; cd07828
335659018572	heme-binding site [chemical binding]; other site
335659018573	PAS fold; Region: PAS_4; pfam08448
335659018574	PAS fold; Region: PAS_4; pfam08448
335659018575	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
335659018576	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
335659018577	dimer interface [polypeptide binding]; other site
335659018578	phosphorylation site [posttranslational modification]
335659018579	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
335659018580	ATP binding site [chemical binding]; other site
335659018581	Mg2+ binding site [ion binding]; other site
335659018582	G-X-G motif; other site
335659018583	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
335659018584	Response regulator receiver domain; Region: Response_reg; pfam00072
335659018585	active site
335659018586	phosphorylation site [posttranslational modification]
335659018587	intermolecular recognition site; other site
335659018588	dimerization interface [polypeptide binding]; other site
335659018589	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
335659018590	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
335659018591	DNA binding residues [nucleotide binding]
335659018592	dimerization interface [polypeptide binding]; other site
335659018593	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
335659018594	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
335659018595	DNA binding residues [nucleotide binding]
335659018596	dimerization interface [polypeptide binding]; other site
335659018597	Transcriptional regulator [Transcription]; Region: LysR; COG0583
335659018598	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
335659018599	The C-teminal substrate binding domain of LysR-like nitrogen assimilation control (NAC) protein, contains the type 2 periplasmic binding fold; Region: PBP2_Nac; cd08433
335659018600	putative dimerization interface [polypeptide binding]; other site
335659018601	ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components [Inorganic ion transport and metabolism]; Region: TauA; COG0715
335659018602	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cl17432
335659018603	ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116
335659018604	ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293
335659018605	Walker A/P-loop; other site
335659018606	ATP binding site [chemical binding]; other site
335659018607	Q-loop/lid; other site
335659018608	ABC transporter signature motif; other site
335659018609	Walker B; other site
335659018610	D-loop; other site
335659018611	H-loop/switch region; other site
335659018612	ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600
335659018613	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
335659018614	dimer interface [polypeptide binding]; other site
335659018615	conserved gate region; other site
335659018616	putative PBP binding loops; other site
335659018617	ABC-ATPase subunit interface; other site
335659018618	Anaerobic dehydrogenases, typically selenocysteine-containing [Energy production and conversion]; Region: BisC; COG0243
335659018619	The MopB_3 CD includes a group of related uncharacterized bacterial and archaeal molybdopterin-binding oxidoreductase-like domains with a putative N-terminal iron-sulfur [4Fe-4S] cluster binding site and molybdopterin cofactor binding site. These members...; Region: MopB_3; cd02766
335659018620	putative [4Fe-4S] binding site [ion binding]; other site
335659018621	putative molybdopterin cofactor binding site [chemical binding]; other site
335659018622	The MopB_CT_3 CD includes a group of related uncharacterized bacterial molybdopterin-binding oxidoreductase-like domains with a putative N-terminal iron-sulfur [4Fe-4S] cluster binding site and molybdopterin cofactor binding site. This CD is of the...; Region: MopB_CT_3; cd02786
335659018623	putative molybdopterin cofactor binding site; other site
335659018624	HD domain protein, cyanamide hydratase family; Region: cyanamide_fam; TIGR03401
335659018625	Transcriptional regulator containing an amidase domain and an AraC-type DNA-binding HTH domain [Transcription]; Region: COG4977
335659018626	AraC transcriptional regulators having a Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GATase1_AraC_1; cd03137
335659018627	conserved cys residue [active]
335659018628	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
335659018629	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
335659018630	Uncharacterized conserved protein, contains double-stranded beta-helix domain [Function unknown]; Region: COG1917
335659018631	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
335659018632	Zn2+ binding site [ion binding]; other site
335659018633	Mg2+ binding site [ion binding]; other site
335659018634	NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604
335659018635	alcohol dehydrogenase and quinone reductase-like medium chain degydrogenases/reductases; Region: MDR_like_2; cd05289
335659018636	putative NAD(P) binding site [chemical binding]; other site
335659018637	zinc-binding protein; Provisional; Region: PRK01343
335659018638	Maf-like protein; Region: Maf; pfam02545
335659018639	Nucleotide binding protein Maf. Maf has been implicated in inhibition of septum formation in eukaryotes, bacteria and archaea, but homologs in B.subtilis and S.cerevisiae are nonessential for cell division. Maf has been predicted to be a nucleotide- or...; Region: Maf; cd00555
335659018640	active site
335659018641	dimer interface [polypeptide binding]; other site
335659018642	Protein-tyrosine-phosphatase [Signal transduction mechanisms]; Region: Wzb; COG0394
335659018643	Low molecular weight phosphatase family; Region: LMWPc; cd00115
335659018644	active site
335659018645	hypothetical protein; Provisional; Region: PRK02853
335659018646	histidinol dehydrogenase; Region: hisD; TIGR00069
335659018647	Histidinol dehydrogenase, HisD, E.C 1.1.1.23. Histidinol dehydrogenase catalyzes the last two steps in the L-histidine biosynthesis pathway, which is conserved in bacteria, archaea, fungi, and plants. These last two steps are (i) the NAD-dependent...; Region: Histidinol_dh; cd06572
335659018648	NAD binding site [chemical binding]; other site
335659018649	dimerization interface [polypeptide binding]; other site
335659018650	product binding site; other site
335659018651	substrate binding site [chemical binding]; other site
335659018652	zinc binding site [ion binding]; other site
335659018653	catalytic residues [active]
335659018654	Protein of unknown function (DUF2948); Region: DUF2948; pfam11164
335659018655	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
335659018656	NADH(P)-binding; Region: NAD_binding_10; pfam13460
335659018657	NAD(P) binding site [chemical binding]; other site
335659018658	active site
335659018659	short chain dehydrogenase; Provisional; Region: PRK06197
335659018660	retinol dehydrogenase (retinol-DH), Light dependent Protochlorophyllide (Pchlide) OxidoReductase (LPOR) and related proteins, classical (c) SDRs; Region: retinol-DH_like_SDR_c_like; cd05327
335659018661	putative NAD(P) binding site [chemical binding]; other site
335659018662	active site
335659018663	mycofactocin system transcriptional regulator; Region: mycofact_TetR; TIGR03968
335659018664	Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596
335659018665	Putative lysophospholipase; Region: Hydrolase_4; pfam12146
335659018666	Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326
335659018667	EthD domain; Region: EthD; cl17553
335659018668	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
335659018669	cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664
335659018670	ligand binding site [chemical binding]; other site
335659018671	Thioredoxin reductase [Posttranslational modification, protein turnover, chaperones]; Region: TrxB; COG0492
335659018672	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
335659018673	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
335659018674	cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664
335659018675	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
335659018676	ligand binding site [chemical binding]; other site
335659018677	MgtC family; Region: MgtC; pfam02308
335659018678	L-alanine-DL-glutamate epimerase and related enzymes of enolase superfamily [Cell envelope biogenesis, outer membrane / General function prediction only]; Region: COG4948
335659018679	Mandelate racemase (MR)-like subfamily of the enolase superfamily, subgroup 1. Enzymes of this subgroup share three conserved carboxylate ligands for the essential divalent metal ion (usually Mg2+), two aspartates and a glutamate, and conserved catalytic...; Region: MR_like_1; cd03326
335659018680	putative active site pocket [active]
335659018681	metal binding site [ion binding]; metal-binding site
335659018682	Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cd00347
335659018683	luciferase family oxidoreductase, group 1; Region: oxido_grp_1; TIGR03558
335659018684	Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892
335659018685	Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cd00347
335659018686	Predicted metal-dependent hydrolase of the TIM-barrel fold [General function prediction only]; Region: COG3618
335659018687	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
335659018688	active site
335659018689	YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448
335659018690	homotrimer interaction site [polypeptide binding]; other site
335659018691	putative active site [active]
335659018692	Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; cl11421
335659018693	2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179
335659018694	Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557
335659018695	Conserved protein/domain typically associated with flavoprotein oxygenases, DIM6/NTAB family [General function prediction only]; Region: COG1853
335659018696	Tripartite tricarboxylate transporter family receptor; Region: TctC; cl17792
335659018697	Transcriptional regulator [Transcription]; Region: IclR; COG1414
335659018698	IclR helix-turn-helix domain; Region: HTH_IclR; pfam09339
335659018699	Bacterial transcriptional regulator; Region: IclR; pfam01614
335659018700	O-acetylhomoserine aminocarboxypropyltransferase; Validated; Region: PRK08134
335659018701	CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614
335659018702	homodimer interface [polypeptide binding]; other site
335659018703	substrate-cofactor binding pocket; other site
335659018704	pyridoxal 5'-phosphate binding site [chemical binding]; other site
335659018705	catalytic residue [active]
335659018706	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
335659018707	Novel bacterial esterase that cleaves esters on halogenated cyclic compounds; Region: Esterase_713_like; cl17303
335659018708	ABC transporter, substrate-binding protein, aliphatic sulfonates family; Region: SsuA_fam; TIGR01728
335659018709	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
335659018710	substrate binding pocket [chemical binding]; other site
335659018711	membrane-bound complex binding site; other site
335659018712	hinge residues; other site
335659018713	classical (c) SDRs; Region: SDR_c; cd05233
335659018714	NAD(P) binding site [chemical binding]; other site
335659018715	active site
335659018716	Opacity protein and related surface antigens [Cell envelope biogenesis, outer membrane]; Region: COG3637
335659018717	Opacity protein and related surface antigens [Cell envelope biogenesis, outer membrane]; Region: COG3637
335659018718	Opacity protein and related surface antigens [Cell envelope biogenesis, outer membrane]; Region: COG3637
335659018719	PPOX class probable FMN-dependent enzyme, DR_2398 family; Region: PPOX_FMN_DR2398; TIGR04025
335659018720	Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates...; Region: NK; cl17190
335659018721	active site
335659018722	phosphonate metabolism protein PhnM; Provisional; Region: PRK15446
335659018723	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
335659018724	PhnM is believed to be a subunit of the membrane associated C-P lyase complex. C-P lyase is thought to catalyze the direct cleavage of inactivated C-P bonds to yield inorganic phosphate and the corresponding hydrocarbons. It is responsible for cleavage...; Region: PhnM; cd01306
335659018725	active site
335659018726	phosphonate C-P lyase system protein PhnL; Region: CP_lyasePhnL; TIGR02324
335659018727	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
335659018728	Walker A/P-loop; other site
335659018729	ATP binding site [chemical binding]; other site
335659018730	Q-loop/lid; other site
335659018731	ABC transporter signature motif; other site
335659018732	Walker B; other site
335659018733	D-loop; other site
335659018734	H-loop/switch region; other site
335659018735	phosphonate C-P lyase system protein PhnK; Provisional; Region: phnK; PRK11701
335659018736	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
335659018737	Walker A/P-loop; other site
335659018738	ATP binding site [chemical binding]; other site
335659018739	Q-loop/lid; other site
335659018740	ABC transporter signature motif; other site
335659018741	Walker B; other site
335659018742	D-loop; other site
335659018743	H-loop/switch region; other site
335659018744	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097
335659018745	Phosphonate metabolism protein PhnJ; Region: PhnJ; pfam06007
335659018746	Bacterial phosphonate metabolism protein (PhnI); Region: PhnI; pfam05861
335659018747	Bacterial phosphonate metabolism protein (PhnH); Region: PhnH; pfam05845
335659018748	Phosphonate metabolism protein PhnG; Region: PhnG; pfam06754
335659018749	phosphonates metabolism transcriptional regulator PhnF; Region: C_P_lyase_phnF; TIGR02325
335659018750	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
335659018751	DNA-binding site [nucleotide binding]; DNA binding site
335659018752	UTRA domain; Region: UTRA; pfam07702
335659018753	phosphonate ABC transporter, permease protein PhnE; Region: PhnE; TIGR01097
335659018754	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
335659018755	dimer interface [polypeptide binding]; other site
335659018756	conserved gate region; other site
335659018757	ABC-ATPase subunit interface; other site
335659018758	phosphonate ABC transporter, permease protein PhnE; Region: PhnE; TIGR01097
335659018759	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
335659018760	dimer interface [polypeptide binding]; other site
335659018761	conserved gate region; other site
335659018762	putative PBP binding loops; other site
335659018763	ABC-ATPase subunit interface; other site
335659018764	phosphonate ABC transporter, periplasmic phosphonate binding protein; Region: PhnD; TIGR03431
335659018765	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cl17432
335659018766	substrate binding pocket [chemical binding]; other site
335659018767	membrane-bound complex binding site; other site
335659018768	phosphonate ABC transporter, ATP-binding protein; Region: ABC_phnC; TIGR02315
335659018769	ATP-binding cassette domain of the binding protein-dependent phosphonate transport system; Region: ABC_PhnC_transporter; cd03256
335659018770	Walker A/P-loop; other site
335659018771	ATP binding site [chemical binding]; other site
335659018772	Q-loop/lid; other site
335659018773	ABC transporter signature motif; other site
335659018774	Walker B; other site
335659018775	D-loop; other site
335659018776	H-loop/switch region; other site
335659018777	phosphonate metabolim protein, transferase hexapeptide repeat family; Region: phn_thr-fam; TIGR03308
335659018778	Xenobiotic acyltransferase (XAT): The XAT class of hexapeptide acyltransferases is composed of a large number of microbial enzymes that catalyze the CoA-dependent acetylation of a variety of hydroxyl-bearing acceptors such as chloramphenicol and...; Region: LbH_XAT; cd03349
335659018779	trimer interface [polypeptide binding]; other site
335659018780	active site
335659018781	substrate binding site [chemical binding]; other site
335659018782	CoA binding site [chemical binding]; other site
335659018783	phosphonate metabolism protein PhnM; Provisional; Region: PRK15446
335659018784	PhnM is believed to be a subunit of the membrane associated C-P lyase complex. C-P lyase is thought to catalyze the direct cleavage of inactivated C-P bonds to yield inorganic phosphate and the corresponding hydrocarbons. It is responsible for cleavage...; Region: PhnM; cd01306
335659018785	active site
335659018786	putative phosphonate metabolism protein; Region: Phn_opern_protn; TIGR03223
335659018787	Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329
335659018788	Dihydrodipicolinate synthase family; Region: DHDPS-like; cd00408
335659018789	inhibitor site; inhibition site
335659018790	active site
335659018791	dimer interface [polypeptide binding]; other site
335659018792	catalytic residue [active]
335659018793	HAMP domain; Region: HAMP; pfam00672
335659018794	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
335659018795	Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283
335659018796	dimer interface [polypeptide binding]; other site
335659018797	putative CheW interface [polypeptide binding]; other site
335659018798	enoyl-CoA hydratase; Provisional; Region: PRK06688
335659018799	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
335659018800	substrate binding site [chemical binding]; other site
335659018801	oxyanion hole (OAH) forming residues; other site
335659018802	trimer interface [polypeptide binding]; other site
335659018803	helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347
335659018804	MarR family; Region: MarR_2; pfam12802
335659018805	Tannase and feruloyl esterase; Region: Tannase; pfam07519
335659018806	D-3-phosphoglycerate dehydrogenase; Provisional; Region: PRK11790
335659018807	Phosphoglycerate dehydrogenases, NAD-binding and catalytic domains; Region: PGDH_3; cd12176
335659018808	ligand binding site [chemical binding]; other site
335659018809	NAD binding site [chemical binding]; other site
335659018810	tetramer interface [polypeptide binding]; other site
335659018811	catalytic site [active]
335659018812	C-terminal ACT (regulatory) domain of D-3-Phosphoglycerate Dehydrogenase (3PGDH) found in fungi and bacteria; Region: ACT_3PGDH; cd04901
335659018813	L-serine binding site [chemical binding]; other site
335659018814	ACT domain interface; other site
335659018815	Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cl00125
335659018816	active site residue [active]
335659018817	Member of the Rhodanese Homology Domain superfamily, repeat 2. This CD includes putative rhodanese-related sulfurtransferases which contain 4 copies of the Rhodanese Homology Domain. This CD aligns the 2nd repeat which does contain the putative catalytic...; Region: 4RHOD_Repeat_2; cd01533
335659018818	active site residue [active]
335659018819	Member of the Rhodanese Homology Domain superfamily, repeat 3. This CD includes putative rhodanese-related sulfurtransferases which contain 4 copies of the Rhodanese Homology Domain. This CD aligns the 3rd repeat which does not contain the putative...; Region: 4RHOD_Repeat_3; cd01534
335659018820	active site residue [active]
335659018821	Domain of unknown function (DUF1963); Region: DUF1963; cl01600
335659018822	Domain of unknown function (DUF1963); Region: DUF1963; cl01600
335659018823	Uncharacterized iron-regulated membrane protein [Function unknown]; Region: PiuB; COG3182
335659018824	PepSY-associated TM helix; Region: PepSY_TM_2; pfam13703
335659018825	TonB-dependent siderophore receptor; Region: TonB-siderophor; TIGR01783
335659018826	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
335659018827	N-terminal plug; other site
335659018828	ligand-binding site [chemical binding]; other site
335659018829	Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329
335659018830	Dihydrodipicolinate synthase family; Region: DHDPS-like; cd00408
335659018831	inhibitor site; inhibition site
335659018832	active site
335659018833	dimer interface [polypeptide binding]; other site
335659018834	catalytic residue [active]
335659018835	FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277
335659018836	FAD binding domain; Region: FAD_binding_4; pfam01565
335659018837	Transcriptional regulators [Transcription]; Region: GntR; COG1802
335659018838	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
335659018839	DNA-binding site [nucleotide binding]; DNA binding site
335659018840	FCD domain; Region: FCD; pfam07729
335659018841	hypothetical protein; Provisional; Region: PRK01254
335659018842	Radical SAM N-terminal; Region: Radical_SAM_N; pfam08497
335659018843	Domain of unknown function (DUF3362); Region: DUF3362; pfam11842
335659018844	Predicted acetamidase/formamidase [Energy production and conversion]; Region: COG2421
335659018845	ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600
335659018846	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
335659018847	dimer interface [polypeptide binding]; other site
335659018848	conserved gate region; other site
335659018849	putative PBP binding loops; other site
335659018850	ABC-ATPase subunit interface; other site
335659018851	ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116
335659018852	ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293
335659018853	Walker A/P-loop; other site
335659018854	ATP binding site [chemical binding]; other site
335659018855	Q-loop/lid; other site
335659018856	ABC transporter signature motif; other site
335659018857	Walker B; other site
335659018858	D-loop; other site
335659018859	H-loop/switch region; other site
335659018860	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cl17432
335659018861	NMT1/THI5 like; Region: NMT1; pfam09084
335659018862	Transposase; Region: HTH_Tnp_1; pfam01527
335659018863	Winged helix-turn helix; Region: HTH_29; pfam13551
335659018864	Predicted acetamidase/formamidase [Energy production and conversion]; Region: COG2421
335659018865	Rrf2 family protein; Region: rrf2_super; TIGR00738
335659018866	Transcriptional regulator; Region: Rrf2; pfam02082
335659018867	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
335659018868	S-adenosylmethionine binding site [chemical binding]; other site
335659018869	Flavin reductase like domain; Region: Flavin_Reduct; smart00903
335659018870	2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases [Coenzyme metabolism / Energy production and conversion]; Region: UbiH; COG0654
335659018871	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
335659018872	Transcriptional regulator [Transcription]; Region: LysR; COG0583
335659018873	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
335659018874	The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422
335659018875	putative effector binding pocket; other site
335659018876	dimerization interface [polypeptide binding]; other site
335659018877	probable oxidoreductase, LLM family; Region: LLM_2I7G; TIGR03858
335659018878	Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases [Energy production and conversion]; Region: COG2141
335659018879	Protein of unknown function (DUF2846); Region: DUF2846; pfam11008
335659018880	Cellulase (glycosyl hydrolase family 5); Region: Cellulase; pfam00150
335659018881	Uncharacterized protein involved in exopolysaccharide biosynthesis [Cell envelope biogenesis, outer membrane]; Region: GumC; COG3206
335659018882	Chain length determinant protein; Region: Wzz; cl15801
335659018883	Tripartite tricarboxylate transporter family receptor; Region: TctC; cl17792
335659018884	Acyl-CoA synthetase (NDP forming) [Energy production and conversion]; Region: COG1042
335659018885	CoA binding domain; Region: CoA_binding_2; pfam13380
335659018886	Succinyl-CoA ligase like flavodoxin domain; Region: Succ_CoA_lig; pfam13607
335659018887	ATP-grasp domain; Region: ATP-grasp_5; pfam13549
335659018888	Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024
335659018889	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
335659018890	substrate binding site [chemical binding]; other site
335659018891	oxyanion hole (OAH) forming residues; other site
335659018892	trimer interface [polypeptide binding]; other site
335659018893	Transcriptional regulator [Transcription]; Region: IclR; COG1414
335659018894	IclR helix-turn-helix domain; Region: HTH_IclR; pfam09339
335659018895	heavy metal-(Cd/Co/Hg/Pb/Zn)-translocating P-type ATPase; Region: ATPase-IB2_Cd; TIGR01512
335659018896	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
335659018897	Nodulin-21 and CCC1-related protein family; Region: Nodulin-21_like_1; cd02432
335659018898	Cytochrome B561 [Energy production and conversion]; Region: CybB; COG3038
335659018899	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
335659018900	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
335659018901	ATP binding site [chemical binding]; other site
335659018902	Mg2+ binding site [ion binding]; other site
335659018903	G-X-G motif; other site
335659018904	Ribonuclease P; Region: Ribonuclease_P; cl00457
335659018905	membrane protein insertase; Provisional; Region: PRK01318
335659018906	membrane protein insertase, YidC/Oxa1 family, C-terminal domain; Region: yidC_oxa1_cterm; TIGR03592
335659018907	YihA (EngB) GTPase family; Region: YihA_EngB; cd01876
335659018908	G1 box; other site
335659018909	GTP/Mg2+ binding site [chemical binding]; other site
335659018910	Switch I region; other site
335659018911	G2 box; other site
335659018912	G3 box; other site
335659018913	Switch II region; other site
335659018914	G4 box; other site
335659018915	G5 box; other site
335659018916	Protein of unknown function (DUF423); Region: DUF423; cl01008
335659018917	AAK_NAGK-C: N-Acetyl-L-glutamate kinase - cyclic (NAGK-C) catalyzes the phosphorylation of the gamma-COOH group of N-acetyl-L-glutamate (NAG) by ATP in the second step of arginine biosynthesis found in some bacteria and photosynthetic organisms using the...; Region: AAK_NAGK-C; cd04250
335659018918	feedback inhibition sensing region; other site
335659018919	homohexameric interface [polypeptide binding]; other site
335659018920	nucleotide binding site [chemical binding]; other site
335659018921	N-acetyl-L-glutamate binding site [chemical binding]; other site
335659018922	Protein of unknown function (DUF1036); Region: DUF1036; cl02296
335659018923	Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471
335659018924	Protein of unknown function (DUF1036); Region: DUF1036; pfam06282
335659018925	pyrimidine 5'-nucleotidase; Region: Pyr-5-nucltdase; TIGR01993
335659018926	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
335659018927	motif II; other site
335659018928	2,3,4,5-tetrahydropyridine-2,6-carboxylate N-succinyltransferase; Provisional; Region: dapD; PRK11830
335659018929	2,3,4,5-tetrahydropyridine-2,6-dicarboxylate (THDP) N-succinyltransferase (also called THP succinyltransferase): THDP N-succinyltransferase catalyzes the conversion of tetrahydrodipicolinate and succinyl-CoA to N-succinyltetrahydrodipicolinate and CoA; Region: LbH_THP_succinylT; cd03350
335659018930	trimer interface [polypeptide binding]; other site
335659018931	active site
335659018932	substrate binding site [chemical binding]; other site
335659018933	CoA binding site [chemical binding]; other site
335659018934	Protein of unknown function (DUF805); Region: DUF805; pfam05656
335659018935	succinyl-diaminopimelate desuccinylase; Reviewed; Region: PRK13009
335659018936	M20 Peptidase proteobacterial DapE encoded N-succinyl-L,L-diaminopimelic acid desuccinylase; Region: M20_DapE_proteobac; cd03891
335659018937	metal binding site [ion binding]; metal-binding site
335659018938	dimer interface [polypeptide binding]; other site
335659018939	tRNA pseudouridine synthase A; Validated; Region: truA; PRK00021
335659018940	Eukaryotic and bacterial pseudouridine synthases similar to E.  coli TruA; Region: PseudoU_synth_EcTruA; cd02570
335659018941	dimerization interface 3.5A [polypeptide binding]; other site
335659018942	active site
335659018943	methionyl-tRNA formyltransferase; Reviewed; Region: fmt; PRK00005
335659018944	Methionyl-tRNA formyltransferase, N-terminal hydrolase domain; Region: FMT_core_Met-tRNA-FMT_N; cd08646
335659018945	putative active site [active]
335659018946	substrate binding site [chemical binding]; other site
335659018947	putative cosubstrate binding site; other site
335659018948	catalytic site [active]
335659018949	C-terminal domain of Formyltransferase and other enzymes; Region: Met_tRNA_FMT_C; cd08704
335659018950	substrate binding site [chemical binding]; other site
335659018951	Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487
335659018952	active site
335659018953	catalytic residues [active]
335659018954	metal binding site [ion binding]; metal-binding site
335659018955	RmuC family; Region: RmuC; pfam02646
335659018956	muropeptide transporter; Validated; Region: ampG; cl17669
335659018957	muropeptide transporter; Reviewed; Region: ampG; PRK11902
335659018958	recombination protein RecR; Reviewed; Region: recR; PRK00076
335659018959	RecR protein; Region: RecR; pfam02132
335659018960	TOPRIM_recR: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in Escherichia coli RecR.  RecR participates in the RecFOR pathway of homologous recombinational repair in prokaryotes. This pathway provides a...; Region: TOPRIM_recR; cd01025
335659018961	tetramer interface [polypeptide binding]; other site
335659018962	putative active site [active]
335659018963	putative metal-binding site [ion binding]; other site
335659018964	hypothetical protein; Validated; Region: PRK00153
335659018965	DNA polymerase III subunits gamma and tau; Validated; Region: PRK09111
335659018966	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
335659018967	Walker A motif; other site
335659018968	ATP binding site [chemical binding]; other site
335659018969	Walker B motif; other site
335659018970	arginine finger; other site
335659018971	DNA polymerase III subunits gamma and tau domain III; Region: DNA_pol3_gamma3; pfam12169
335659018972	DNA polymerase III gamma and tau subunits C terminal; Region: DUF3646; pfam12362
335659018973	Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497
335659018974	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
335659018975	substrate binding pocket [chemical binding]; other site
335659018976	membrane-bound complex binding site; other site
335659018977	hinge residues; other site
335659018978	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
335659018979	dimer interface [polypeptide binding]; other site
335659018980	conserved gate region; other site
335659018981	putative PBP binding loops; other site
335659018982	ABC-ATPase subunit interface; other site
335659018983	ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126
335659018984	ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262
335659018985	Walker A/P-loop; other site
335659018986	ATP binding site [chemical binding]; other site
335659018987	Q-loop/lid; other site
335659018988	ABC transporter signature motif; other site
335659018989	Walker B; other site
335659018990	D-loop; other site
335659018991	H-loop/switch region; other site
335659018992	3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653
335659018993	classical (c) SDRs; Region: SDR_c; cd05233
335659018994	NAD(P) binding site [chemical binding]; other site
335659018995	active site
335659018996	Muconate Lactonizing Enzyme (MLE), an homooctameric enzyme, catalyses the conversion of cis,cis-muconate (CCM) to muconolactone (ML) in the catechol branch of the beta-ketoadipate pathway. This pathway is used in soil microbes to breakdown lignin-derived...; Region: MLE; cd03318
335659018997	muconate and chloromuconate cycloisomerases; Region: mucon_cyclo; TIGR02534
335659018998	octamer interface [polypeptide binding]; other site
335659018999	active site
335659019000	HIT family: HIT (Histidine triad) proteins, named for a motif related to the sequence HxHxH/Qxx (x, a hydrophobic amino acid), are a superfamily of nucleotide hydrolases and transferases, which act on the alpha-phosphate of ribonucleotides. On the basis...; Region: HIT_like; cl00228
335659019001	nucleotide binding site/active site [active]
335659019002	HIT family signature motif; other site
335659019003	catalytic residue [active]
335659019004	NTP pyrophosphohydrolases containing a Zn-finger, probably nucleic-acid-binding [DNA replication, recombination, and repair]; Region: NPY1; COG2816
335659019005	NADH pyrophosphatase-like rudimentary NUDIX domain; Region: NUDIX-like; pfam09296
335659019006	NADH pyrophosphatase zinc ribbon domain; Region: zf-NADH-PPase; pfam09297
335659019007	NADH pyrophosphatase, a member of the Nudix hydrolase superfamily, catalyzes the cleavage of NADH into reduced nicotinamide mononucleotide (NMNH) and AMP. Like other members of the Nudix family, it requires a divalent cation, such as Mg2+ or Mn2+, for...; Region: NADH_pyrophosphatase; cd03429
335659019008	putative NADH binding site [chemical binding]; other site
335659019009	putative active site [active]
335659019010	nudix motif; other site
335659019011	putative metal binding site [ion binding]; other site
335659019012	Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524
335659019013	Ribokinase-like subgroup B.  Found in bacteria and plants, this subgroup is part of the ribokinase/pfkB superfamily.  Its oligomerization state is unknown at this time; Region: ribokinase_group_B; cd01945
335659019014	substrate binding site [chemical binding]; other site
335659019015	ATP binding site [chemical binding]; other site
335659019016	Transcriptional regulators [Transcription]; Region: Lrp; COG1522
335659019017	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
335659019018	putative DNA binding site [nucleotide binding]; other site
335659019019	putative Zn2+ binding site [ion binding]; other site
335659019020	AsnC family; Region: AsnC_trans_reg; pfam01037
335659019021	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054
335659019022	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
335659019023	Mg2+ binding site [ion binding]; other site
335659019024	G-X-G motif; other site
335659019025	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
335659019026	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
335659019027	active site
335659019028	phosphorylation site [posttranslational modification]
335659019029	intermolecular recognition site; other site
335659019030	dimerization interface [polypeptide binding]; other site
335659019031	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
335659019032	DNA binding site [nucleotide binding]
335659019033	Cysteine rich repeat; Region: Cys_rich_FGFR; pfam00839
335659019034	Sterol desaturase [Lipid metabolism]; Region: ERG3; COG3000
335659019035	Fatty acid hydroxylase superfamily; Region: FA_hydroxylase; pfam04116
335659019036	Phosphomannomutase [Carbohydrate transport and metabolism]; Region: {ManB}; COG1109
335659019037	The phosphomannomutase/phosphoglucomutase (PMM/PGM) bifunctional enzyme catalyzes the reversible conversion of 1-phospho to 6-phospho-sugars (e.g. between mannose-1-phosphate and mannose-6-phosphate or glucose-1-phosphate and glucose-6-phosphate) via a...; Region: PMM_PGM; cd03089
335659019038	active site
335659019039	substrate binding site [chemical binding]; other site
335659019040	metal binding site [ion binding]; metal-binding site
335659019041	Bacterial aspartate proteases, retropepsin-like protease family; Region: retropepsin_like_bacteria; cd05483
335659019042	catalytic motif [active]
335659019043	Catalytic residue [active]
335659019044	ATP-dependent helicase HrpB; Region: DEAH_box_HrpB; TIGR01970
335659019045	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
335659019046	ATP binding site [chemical binding]; other site
335659019047	putative Mg++ binding site [ion binding]; other site
335659019048	nucleotide binding region [chemical binding]; other site
335659019049	helicase superfamily c-terminal domain; Region: HELICc; smart00490
335659019050	ATP-dependent helicase C-terminal; Region: HrpB_C; pfam08482
335659019051	Predicted UDP-glucose 6-dehydrogenase [Cell envelope biogenesis, outer membrane]; Region: Ugd; COG1004
335659019052	NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210
335659019053	UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984
335659019054	UDP binding domain; Region: UDPG_MGDP_dh_C; smart00984
335659019055	Predicted membrane protein [Function unknown]; Region: COG4763
335659019056	Acyltransferase family; Region: Acyl_transf_3; pfam01757
335659019057	5'-3' exonuclease; Region: 53EXOc; smart00475
335659019058	PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859
335659019059	active site
335659019060	metal binding site 1 [ion binding]; metal-binding site
335659019061	putative 5' ssDNA interaction site; other site
335659019062	metal binding site 3; metal-binding site
335659019063	metal binding site 2 [ion binding]; metal-binding site
335659019064	H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898
335659019065	putative DNA binding site [nucleotide binding]; other site
335659019066	putative metal binding site [ion binding]; other site
335659019067	DNA polymerase I - 3'-5' exonuclease and polymerase domains [DNA replication, recombination, and repair]; Region: PolA; COG0749
335659019068	DEDDy 3'-5' exonuclease domain of Escherichia coli DNA polymerase I and similar bacterial family-A DNA polymerases; Region: DNA_polA_I_Ecoli_like_exo; cd06139
335659019069	active site
335659019070	catalytic site [active]
335659019071	substrate binding site [chemical binding]; other site
335659019072	Polymerase I functions primarily to fill DNA gaps that arise during DNA repair, recombination and replication; Region: DNA_pol_A_pol_I_C; cd08637
335659019073	active site
335659019074	DNA binding site [nucleotide binding]
335659019075	catalytic site [active]
335659019076	Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280
335659019077	GSH-dependent disulfide bond oxidoreductase; Provisional; Region: PRK13972
335659019078	GST_N family, Ure2p-like subfamily; composed of the Saccharomyces cerevisiae Ure2p and related GSTs. Ure2p is a regulator for nitrogen catabolism in yeast. It represses the expression of several gene products involved in the use of poor nitrogen sources...; Region: GST_N_Ure2p_like; cd03048
335659019079	C-terminal domain interface [polypeptide binding]; other site
335659019080	GSH binding site (G-site) [chemical binding]; other site
335659019081	dimer interface [polypeptide binding]; other site
335659019082	C-terminal, alpha helical domain of Escherichia coli YfcG Glutathione S-transferases and related uncharacterized proteins; Region: GST_C_YfcG_like; cd10291
335659019083	N-terminal domain interface [polypeptide binding]; other site
335659019084	putative dimer interface [polypeptide binding]; other site
335659019085	active site
335659019086	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
335659019087	active site
335659019088	Protein of unknown function (DUF2865); Region: DUF2865; pfam11064
335659019089	Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149
335659019090	Pyrococcus furiosus PF1019 and related proteins, metallophosphatase domain; Region: MPP_PF1019; cd07391
335659019091	putative active site [active]
335659019092	putative metal binding site [ion binding]; other site
335659019093	DEXH box helicase, DNA ligase-associated; Region: DEXH_lig_assoc; TIGR04121
335659019094	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251
335659019095	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
335659019096	ATP binding site [chemical binding]; other site
335659019097	putative Mg++ binding site [ion binding]; other site
335659019098	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
335659019099	nucleotide binding region [chemical binding]; other site
335659019100	ATP-binding site [chemical binding]; other site
335659019101	DEAD/H associated; Region: DEAD_assoc; pfam08494
335659019102	Type I periplasmic ligand-binding domain of uncharacterized ABC (ATPase Binding Cassette)-type active transport systems that are predicted to be involved in uptake of amino acids, peptides, or inorganic ions; Region: PBP1_ABC_ligand_binding_like_8; cd06343
335659019103	Periplasmic binding protein; Region: Peripla_BP_6; pfam13458
335659019104	putative ligand binding site [chemical binding]; other site
335659019105	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
335659019106	binding surface
335659019107	Predicted methyltransferase (contains TPR repeat) [General function prediction only]; Region: COG4976
335659019108	TPR motif; other site
335659019109	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
335659019110	S-adenosylmethionine binding site [chemical binding]; other site
335659019111	putative exonuclease, DNA ligase-associated; Region: Xnuc_lig_assoc; TIGR04122
335659019112	Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849
335659019113	ATP-dependent DNA ligase; Validated; Region: PRK09247
335659019114	Adenylation domain of putative bacterial ATP-dependent DNA ligases; Region: Adenylation_DNA_ligase_Bac1; cd07897
335659019115	active site
335659019116	DNA binding site [nucleotide binding]
335659019117	The Oligonucleotide/oligosaccharide binding (OB)-fold domain of archaeal and bacterial ATP-dependent DNA ligases is a DNA-binding module that is part of the catalytic core unit; Region: OBF_DNA_ligase_Arch_LigB; cd07972
335659019118	DNA binding site [nucleotide binding]
335659019119	DinF and similar proteins, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_DinF_like; cd13136
335659019120	DNA-damage-inducible SOS response protein; Provisional; Region: PRK10367
335659019121	dihydroorotate dehydrogenase 2; Reviewed; Region: PRK05286
335659019122	Dihydroorotate dehydrogenase (DHOD) class 2. DHOD catalyzes the oxidation of (S)-dihydroorotate to orotate. This is the fourth step and the only redox reaction in the de novo biosynthesis of UMP, the precursor of all pyrimidine nucleotides. DHOD requires...; Region: DHOD_2_like; cd04738
335659019123	quinone interaction residues [chemical binding]; other site
335659019124	active site
335659019125	catalytic residues [active]
335659019126	FMN binding site [chemical binding]; other site
335659019127	substrate binding site [chemical binding]; other site
335659019128	Protein of unknown function (DUF952); Region: DUF952; pfam06108
335659019129	Predicted transcriptional regulator [Transcription]; Region: COG2932
335659019130	Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529
335659019131	Catalytic site [active]
335659019132	Carbonic anhydrase [Inorganic ion transport and metabolism]; Region: Cah; COG3338
335659019133	Carbonic anhydrase alpha, prokaryotic-like subfamily. Carbonic anhydrases (CAs) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism: a nucleophilic attack of a zinc-bound hydroxide ion on carbon...; Region: alpha_CA_prokaryotic_like; cd03124
335659019134	active site
335659019135	zinc binding site [ion binding]; other site
335659019136	lysyl-tRNA synthetase; Reviewed; Region: lysK; PRK00750
335659019137	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
335659019138	active site
335659019139	nucleotide binding site [chemical binding]; other site
335659019140	HIGH motif; other site
335659019141	KMSKS motif; other site
335659019142	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
335659019143	Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497
335659019144	substrate binding pocket [chemical binding]; other site
335659019145	membrane-bound complex binding site; other site
335659019146	hinge residues; other site
335659019147	Uncharacterized protein SCO1/SenC/PrrC, involved in biogenesis of respiratory and photosynthetic systems [General function prediction only]; Region: COG1999
335659019148	SCO (an acronym for Synthesis of Cytochrome c Oxidase) family; composed of proteins similar to Sco1, a membrane-anchored protein possessing a soluble domain with a TRX fold. Members of this family are required for the proper assembly of cytochrome c...; Region: SCO; cd02968
335659019149	Cu(I) binding site [ion binding]; other site
335659019150	Caseinolytic protease (ClpP) is an ATP-dependent protease; Region: Clp_protease_like; cl15763
335659019151	active site
335659019152	putative FAD-binding dehydrogenase; Reviewed; Region: PRK12834
335659019153	FAD binding domain; Region: FAD_binding_2; pfam00890
335659019154	This group of proteins belong to a large family of YjgF/YER057c/UK114-like proteins present in bacteria, archaea, and eukaryotes with no definitive function.  The conserved domain is similar in structure to chorismate mutase but there is no sequence...; Region: YjgF_YER057c_UK114_like_2; cd06150
335659019155	homotrimer interaction site [polypeptide binding]; other site
335659019156	putative active site [active]
335659019157	SnoaL-like domain; Region: SnoaL_2; pfam12680
335659019158	Predicted metal-dependent hydrolase of the TIM-barrel fold [General function prediction only]; Region: COG3618
335659019159	Amidohydrolase; Region: Amidohydro_2; pfam04909
335659019160	active site
335659019161	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
335659019162	Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248
335659019163	active site
335659019164	catalytic tetrad [active]
335659019165	Periplasmic sugar-binding domain of active transport systems that are members of the type I periplasmic binding protein (PBP1) superfamily; Region: PBP1_ABC_sugar_binding_like; cd01536
335659019166	Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407
335659019167	ligand binding site [chemical binding]; other site
335659019168	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
335659019169	Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579
335659019170	TM-ABC transporter signature motif; other site
335659019171	ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411
335659019172	First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216
335659019173	Walker A/P-loop; other site
335659019174	ATP binding site [chemical binding]; other site
335659019175	Q-loop/lid; other site
335659019176	ABC transporter signature motif; other site
335659019177	Walker B; other site
335659019178	D-loop; other site
335659019179	H-loop/switch region; other site
335659019180	xylose isomerase; Provisional; Region: PRK05474
335659019181	xylose isomerase; Region: xylose_isom_A; TIGR02630
335659019182	Escherichia coli xylulokinase-like D-xylulose kinases; a subgroup of the FGGY family of carbohydrate kinases; Region: FGGY_D-XK_EcXK-like; cd07808
335659019183	N- and C-terminal domain interface [polypeptide binding]; other site
335659019184	D-xylulose kinase; Region: XylB; TIGR01312
335659019185	active site
335659019186	MgATP binding site [chemical binding]; other site
335659019187	catalytic site [active]
335659019188	metal binding site [ion binding]; metal-binding site
335659019189	xylulose binding site [chemical binding]; other site
335659019190	homodimer interface [polypeptide binding]; other site
335659019191	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
335659019192	DNA binding site [nucleotide binding]
335659019193	domain linker motif; other site
335659019194	Periplasmic sugar-binding domain of uncharacterized transport systems; Region: PBP1_uncharacterized_sugar_binding; cd06307
335659019195	Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407
335659019196	putative ligand binding site [chemical binding]; other site
335659019197	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
335659019198	Coenzyme A binding pocket [chemical binding]; other site
335659019199	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
335659019200	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
335659019201	non-specific DNA binding site [nucleotide binding]; other site
335659019202	salt bridge; other site
335659019203	sequence-specific DNA binding site [nucleotide binding]; other site
335659019204	Cupin domain; Region: Cupin_2; cl17218
335659019205	Methylated DNA-protein cysteine methyltransferase [DNA replication, recombination, and repair]; Region: Ada; COG0350
335659019206	The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445
335659019207	DNA binding site [nucleotide binding]
335659019208	active site
335659019209	AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207
335659019210	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
335659019211	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
335659019212	This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_19; cd07262
335659019213	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
335659019214	Pyrabactin resistance 1 (PYR1), PYR1-like (PYL), regulatory component of abscisic acid receptors (RCARs), and related proteins; Region: PYR_PYL_RCAR_like; cd07821
335659019215	putative hydrophobic ligand binding site [chemical binding]; other site
335659019216	protein interface [polypeptide binding]; other site
335659019217	gate; other site
335659019218	Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; Region: MATE_like_3; cd13148
335659019219	putative efflux protein, MATE family; Region: matE; TIGR00797
335659019220	2'-deoxycytidine 5'-triphosphate deaminase; Provisional; Region: PRK07559
335659019221	Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cl00493
335659019222	trimer interface [polypeptide binding]; other site
335659019223	active site
335659019224	Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cl00493
335659019225	S-adenosylmethionine (SAM) riboswitch (alpha-proteobacteria) as predicted by Rfam v8.1 (RF00521), score 84.97
335659019226	O-succinylhomoserine sulfhydrylase; Reviewed; Region: PRK07504
335659019227	CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614
335659019228	homodimer interface [polypeptide binding]; other site
335659019229	substrate-cofactor binding pocket; other site
335659019230	pyridoxal 5'-phosphate binding site [chemical binding]; other site
335659019231	catalytic residue [active]
335659019232	SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cl01053
335659019233	active site
335659019234	oxyanion hole [active]
335659019235	catalytic triad [active]
335659019236	SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cl01053
335659019237	active site
335659019238	oxyanion hole [active]
335659019239	OpgC protein; Region: OpgC_C; pfam10129
335659019240	Acyltransferase family; Region: Acyl_transf_3; pfam01757
335659019241	CO2+/MG2+ efflux protein ApaG; Reviewed; Region: apaG; PRK05461
335659019242	Heat shock protein 33 (Hsp33):  Cytosolic protein that acts as a molecular chaperone under oxidative conditions.  In normal (reducing) cytosolic conditions, four conserved Cys residues are coordinated by a Zn ion. Under oxidative stress (such as heat...; Region: Hsp33; cd00498
335659019243	Hsp33-like chaperonin; Reviewed; Region: hslO; PRK00114
335659019244	dimerization interface [polypeptide binding]; other site
335659019245	domain crossover interface; other site
335659019246	redox-dependent activation switch; other site
335659019247	ornithine carbamoyltransferase; Provisional; Region: PRK00779
335659019248	Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729
335659019249	Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185
335659019250	acetylornithine transaminase protein; Provisional; Region: argD; PRK01278
335659019251	Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610
335659019252	inhibitor-cofactor binding pocket; inhibition site
335659019253	pyridoxal 5'-phosphate binding site [chemical binding]; other site
335659019254	catalytic residue [active]
335659019255	GcrA cell cycle regulator; Region: GcrA; pfam07750
335659019256	phosphate regulon transcriptional regulatory protein PhoB; Region: PhoB; TIGR02154
335659019257	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
335659019258	active site
335659019259	phosphorylation site [posttranslational modification]
335659019260	intermolecular recognition site; other site
335659019261	dimerization interface [polypeptide binding]; other site
335659019262	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
335659019263	DNA binding site [nucleotide binding]
335659019264	phosphate transport system regulatory protein PhoU; Region: phoU_full; TIGR02135
335659019265	PhoU domain; Region: PhoU; pfam01895
335659019266	PhoU domain; Region: PhoU; pfam01895
335659019267	phosphate transporter ATP-binding protein; Provisional; Region: pstB; PRK10744
335659019268	ATP-binding cassette domain of the phosphate transport system; Region: ABC_PstB_phosphate_transporter; cd03260
335659019269	Walker A/P-loop; other site
335659019270	ATP binding site [chemical binding]; other site
335659019271	Q-loop/lid; other site
335659019272	ABC transporter signature motif; other site
335659019273	Walker B; other site
335659019274	D-loop; other site
335659019275	H-loop/switch region; other site
335659019276	phosphate transporter permease subunit PtsA; Provisional; Region: pstA; PRK11268
335659019277	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
335659019278	dimer interface [polypeptide binding]; other site
335659019279	conserved gate region; other site
335659019280	putative PBP binding loops; other site
335659019281	ABC-ATPase subunit interface; other site
335659019282	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
335659019283	dimer interface [polypeptide binding]; other site
335659019284	conserved gate region; other site
335659019285	putative PBP binding loops; other site
335659019286	ABC-ATPase subunit interface; other site
335659019287	PBP superfamily domain; Region: PBP_like_2; cl17296
335659019288	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
335659019289	dimer interface [polypeptide binding]; other site
335659019290	phosphorylation site [posttranslational modification]
335659019291	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
335659019292	ATP binding site [chemical binding]; other site
335659019293	Mg2+ binding site [ion binding]; other site
335659019294	G-X-G motif; other site
335659019295	Predicted integral membrane protein [Function unknown]; Region: COG0392
335659019296	Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885
335659019297	Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185
335659019298	ligand binding site [chemical binding]; other site
335659019299	Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726
335659019300	Catalytic NodB homology domain of the carbohydrate esterase 4 superfamily; Region: CE4_SF; cl15692
335659019301	Putative catalytic NodB homology domain of Mesorhizobium loti Mlr8448 protein and its bacterial homologs; Region: CE4_Mlr8448_like_5s; cd10968
335659019302	putative active site [active]
335659019303	gluconate 5-dehydrogenase; Provisional; Region: PRK08213
335659019304	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
335659019305	NAD(P) binding site [chemical binding]; other site
335659019306	active site
335659019307	benzoyl-CoA oxygenase, B subunit; Region: benzo_boxB; TIGR03225
335659019308	benzoyl-CoA-dihydrodiol lyase; Provisional; Region: PRK08184
335659019309	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
335659019310	substrate binding site [chemical binding]; other site
335659019311	oxyanion hole (OAH) forming residues; other site
335659019312	trimer interface [polypeptide binding]; other site
335659019313	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cl15762
335659019314	substrate binding site [chemical binding]; other site
335659019315	oxyanion hole (OAH) forming residues; other site
335659019316	trimer interface [polypeptide binding]; other site
335659019317	Domain of unknown function (DUF309); Region: DUF309; pfam03745
335659019318	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
335659019319	benzoate-CoA ligase family; Region: benz_CoA_lig; TIGR02262
335659019320	Benzoate CoA ligase (BCL) and 4-Hydroxybenzoate-Coenzyme A Ligase (4-HBA-CoA ligase); Region: BCL_4HBCL; cd05959
335659019321	dimer interface [polypeptide binding]; other site
335659019322	acyl-activating enzyme (AAE) consensus motif; other site
335659019323	putative active site [active]
335659019324	putative AMP binding site [chemical binding]; other site
335659019325	putative CoA binding site [chemical binding]; other site
335659019326	chemical substrate binding site [chemical binding]; other site
335659019327	anaerobic benzoate catabolism transcriptional regulator; Reviewed; Region: PRK08154
335659019328	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
335659019329	non-specific DNA binding site [nucleotide binding]; other site
335659019330	salt bridge; other site
335659019331	sequence-specific DNA binding site [nucleotide binding]; other site
335659019332	Shikimate kinase (SK) is the fifth enzyme in the shikimate pathway, a seven-step biosynthetic pathway which converts erythrose-4-phosphate to chorismic acid, found in bacteria, fungi and plants. Chorismic acid is a important intermediate in the synthesis...; Region: SK; cd00464
335659019333	ADP binding site [chemical binding]; other site
335659019334	magnesium binding site [ion binding]; other site
335659019335	putative shikimate binding site; other site
335659019336	Truncated hemoglobins (trHbs) are a family of oxygen-binding heme proteins found in cyanobacteria, eubacteria, unicellular eukaryotes, and plants. The truncated hemoglobins have a characteristic two-over-two alpha helical folding pattern that is distinct...; Region: Trunc_globin; cd00454
335659019337	apolar tunnel; other site
335659019338	heme binding site [chemical binding]; other site
335659019339	dimerization interface [polypeptide binding]; other site
335659019340	putative cation:proton antiport protein; Provisional; Region: PRK10669
335659019341	Kef-type K+ transport system, predicted NAD-binding component [Inorganic ion transport and metabolism]; Region: RosB; COG4651
335659019342	TrkA-N domain; Region: TrkA_N; pfam02254
335659019343	beta-ketoadipate pathway transcriptional regulators, PcaR/PcaU/PobR family; Region: pcaR_pcaU; TIGR02431
335659019344	helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346
335659019345	Bacterial transcriptional regulator; Region: IclR; pfam01614
335659019346	Rieske non-heme iron oxygenase (RO) family, Phthalate 4,5-dioxygenase (PhDO)-like subfamily, N-terminal Rieske domain of the oxygenase alpha subunit; composed of the oxygenase alpha subunits of PhDO and similar proteins including 3-chlorobenzoate 3; Region: Rieske_RO_Alpha_PhDO_like; cd03479
335659019347	Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638
335659019348	C-terminal catalytic domain of the oxygenase alpha subunit of dicamba O-demethylase and related aromatic ring hydroxylating dioxygenases; Region: RHO_alpha_C_DMO-like; cd08878
335659019349	alpha subunit interface [polypeptide binding]; other site
335659019350	active site
335659019351	substrate binding site [chemical binding]; other site
335659019352	Fe binding site [ion binding]; other site
335659019353	Glutamine synthetase [Amino acid transport and metabolism]; Region: GlnA; COG0174
335659019354	Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120
335659019355	ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410
335659019356	ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224
335659019357	Walker A/P-loop; other site
335659019358	ATP binding site [chemical binding]; other site
335659019359	Q-loop/lid; other site
335659019360	ABC transporter signature motif; other site
335659019361	Walker B; other site
335659019362	D-loop; other site
335659019363	H-loop/switch region; other site
335659019364	ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411
335659019365	ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219
335659019366	Walker A/P-loop; other site
335659019367	ATP binding site [chemical binding]; other site
335659019368	Q-loop/lid; other site
335659019369	ABC transporter signature motif; other site
335659019370	Walker B; other site
335659019371	D-loop; other site
335659019372	H-loop/switch region; other site
335659019373	ABC-type branched-chain amino acid transport system, permease component [Amino acid transport and metabolism]; Region: LivM; COG4177
335659019374	Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581
335659019375	TM-ABC transporter signature motif; other site
335659019376	Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582
335659019377	TM-ABC transporter signature motif; other site
335659019378	Autoinducer synthetase; Region: Autoind_synth; cl17404
335659019379	Autoinducer binding domain; Region: Autoind_bind; pfam03472
335659019380	transcriptional regulator TraR; Provisional; Region: PRK13870
335659019381	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
335659019382	DNA binding residues [nucleotide binding]
335659019383	dimerization interface [polypeptide binding]; other site
335659019384	shikimate 5-dehydrogenase; Reviewed; Region: PRK12549
335659019385	Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501
335659019386	NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065
335659019387	shikimate binding site; other site
335659019388	NAD(P) binding site [chemical binding]; other site
335659019389	Periplasmic binding protein; Region: Peripla_BP_6; pfam13458
335659019390	Type I periplasmic binding component of active transport systems that are predicted to be involved in 2-nitrobenzoic acid degradation pathway; Region: PBP1_Nba_like; cd06359
335659019391	putative ligand binding site [chemical binding]; other site
335659019392	NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252
335659019393	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
335659019394	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
335659019395	Periplasmic binding protein; Region: Peripla_BP_6; pfam13458
335659019396	Periplasmic solute-binding domain of active transport proteins that belong to the type I periplasmic binding fold protein family; Region: PBP1_SBP_like_1; cd06327
335659019397	putative ligand binding site [chemical binding]; other site
335659019398	Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124
335659019399	Cytochrome P450; Region: p450; cl12078
335659019400	helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347
335659019401	MarR family; Region: MarR_2; pfam12802
335659019402	feruloyl-CoA synthase; Reviewed; Region: PRK08180
335659019403	Feruloyl-CoA synthetase (FCS); Region: FCS; cd05921
335659019404	acyl-activating enzyme (AAE) consensus motif; other site
335659019405	putative AMP binding site [chemical binding]; other site
335659019406	putative active site [active]
335659019407	putative CoA binding site [chemical binding]; other site
335659019408	helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347
335659019409	MarR family; Region: MarR_2; pfam12802
335659019410	allophanate hydrolase; Provisional; Region: PRK08186
335659019411	Amidase; Region: Amidase; pfam01425
335659019412	Transcriptional regulators [Transcription]; Region: GntR; COG1802
335659019413	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
335659019414	DNA-binding site [nucleotide binding]; DNA binding site
335659019415	FCD domain; Region: FCD; pfam07729
335659019416	Protein of unknown function (DUF3225); Region: DUF3225; pfam11533
335659019417	amidase; Provisional; Region: PRK09201
335659019418	Amidase; Region: Amidase; cl11426
335659019419	Protein of unknown function (DUF4089); Region: DUF4089; pfam13318
335659019420	ATPase components of various ABC-type transport systems, contain duplicated ATPase [General function prediction only]; Region: COG1123
335659019421	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
335659019422	Walker A/P-loop; other site
335659019423	ATP binding site [chemical binding]; other site
335659019424	Q-loop/lid; other site
335659019425	ABC transporter signature motif; other site
335659019426	Walker B; other site
335659019427	D-loop; other site
335659019428	H-loop/switch region; other site
335659019429	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; pfam08352
335659019430	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
335659019431	Walker A/P-loop; other site
335659019432	ATP binding site [chemical binding]; other site
335659019433	Q-loop/lid; other site
335659019434	ABC transporter signature motif; other site
335659019435	Walker B; other site
335659019436	D-loop; other site
335659019437	H-loop/switch region; other site
335659019438	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097
335659019439	nickel ABC transporter, permease subunit NikC; Region: nickel_nikC; TIGR02790
335659019440	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
335659019441	dimer interface [polypeptide binding]; other site
335659019442	conserved gate region; other site
335659019443	putative PBP binding loops; other site
335659019444	ABC-ATPase subunit interface; other site
335659019445	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601
335659019446	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
335659019447	dimer interface [polypeptide binding]; other site
335659019448	conserved gate region; other site
335659019449	putative PBP binding loops; other site
335659019450	ABC-ATPase subunit interface; other site
335659019451	The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_7; cd08512
335659019452	Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496
335659019453	Phosphotransferase enzyme family; Region: APH; pfam01636
335659019454	Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cd05120
335659019455	active site
335659019456	ATP binding site [chemical binding]; other site
335659019457	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653
335659019458	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199
335659019459	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
335659019460	dimerization interface [polypeptide binding]; other site
335659019461	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
335659019462	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
335659019463	ATP binding site [chemical binding]; other site
335659019464	G-X-G motif; other site
335659019465	FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784
335659019466	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
335659019467	active site
335659019468	phosphorylation site [posttranslational modification]
335659019469	intermolecular recognition site; other site
335659019470	dimerization interface [polypeptide binding]; other site
335659019471	Domain of unknown function (DUF3369); Region: DUF3369; pfam11849
335659019472	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
335659019473	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
335659019474	dimer interface [polypeptide binding]; other site
335659019475	phosphorylation site [posttranslational modification]
335659019476	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
335659019477	ATP binding site [chemical binding]; other site
335659019478	Mg2+ binding site [ion binding]; other site
335659019479	G-X-G motif; other site
335659019480	osmolarity response regulator; Provisional; Region: ompR; PRK09468
335659019481	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
335659019482	active site
335659019483	phosphorylation site [posttranslational modification]
335659019484	intermolecular recognition site; other site
335659019485	dimerization interface [polypeptide binding]; other site
335659019486	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
335659019487	DNA binding site [nucleotide binding]
335659019488	RNA polymerase sigma factor; Provisional; Region: PRK12515
335659019489	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
335659019490	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
335659019491	DNA binding residues [nucleotide binding]
335659019492	Cytochrome c biogenesis protein [Posttranslational modification, protein turnover, chaperones]; Region: CcdA; COG0785
335659019493	Cytochrome C biogenesis protein transmembrane region; Region: DsbD; cl15788
335659019494	TlpA-like family, DipZ-like subfamily; composed uncharacterized proteins containing a TlpA-like TRX domain. Some members show domain architectures similar to that of E. coli DipZ protein (also known as DsbD). The only eukaryotic members of the TlpA...; Region: TlpA_like_DipZ_like; cd03012
335659019495	Thioredoxin-like; Region: Thioredoxin_8; pfam13905
335659019496	catalytic residues [active]
335659019497	Bacterial Cytochrome Ubiquinol Oxidase; Region: Bac_Ubq_Cox; pfam01654
335659019498	Cytochrome oxidase subunit II; Region: Cyto_ox_2; pfam02322
335659019499	cytochrome d ubiquinol oxidase subunit 2; Provisional; Region: PRK15003; cl12219
335659019500	Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376
335659019501	L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734
335659019502	Bacterial periplasmic substrate-binding proteins; Region: PBPb; smart00062
335659019503	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
335659019504	substrate binding pocket [chemical binding]; other site
335659019505	membrane-bound complex binding site; other site
335659019506	hinge residues; other site
335659019507	pimeloyl-CoA dehydrogenase, small subunit; Region: pimD_small; TIGR03203
335659019508	Acyl-CoA dehydrogenase, N-terminal domain; Region: Acyl-CoA_dh_N; pfam02771
335659019509	Acyl-CoA dehydrogenase; Region: ACAD; cd00567
335659019510	active site
335659019511	pimeloyl-CoA dehydrogenase, large subunit; Region: pimC_large; TIGR03204
335659019512	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
335659019513	active site
335659019514	Carboxymuconolactone decarboxylase family; Region: CMD; pfam02627
335659019515	This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_12; cd07255
335659019516	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
335659019517	putative metal binding site [ion binding]; other site
335659019518	Major Facilitator Superfamily; Region: MFS_1; pfam07690
335659019519	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
335659019520	putative substrate translocation pore; other site
335659019521	Major Facilitator Superfamily; Region: MFS_1; pfam07690
335659019522	Serine proteases of the peptidase family S9A [Amino acid transport and metabolism]; Region: COG1505
335659019523	Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326
335659019524	Protein of unknown function (DUF938); Region: DUF938; pfam06080
335659019525	Cytochrome c; Region: Cytochrom_C; pfam00034
335659019526	sulfur oxidation protein SoxY; Provisional; Region: PRK07474
335659019527	Sulfur oxidation protein SoxY; Region: SoxY; pfam13501
335659019528	Sulphur oxidation protein SoxZ; Region: SoxZ; pfam08770
335659019529	Cytochrome c [Energy production and conversion]; Region: COG3258
335659019530	5'-nucleotidase/2',3'-cyclic phosphodiesterase and related esterases [Nucleotide transport and metabolism]; Region: UshA; COG0737
335659019531	Thermus thermophilus SoxB and related proteins, N-terminal metallophosphatase domain; Region: MPP_SoxB_N; cd07411
335659019532	active site
335659019533	metal binding site [ion binding]; metal-binding site
335659019534	5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872
335659019535	Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446
335659019536	Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cl00125
335659019537	active site residue [active]
335659019538	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
335659019539	putative substrate translocation pore; other site
335659019540	Major Facilitator Superfamily; Region: MFS_1; pfam07690
335659019541	N-acyl-D-aspartate/D-glutamate deacylase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3653
335659019542	D-aminoacylases (N-acyl-D-Amino acid amidohydrolases) catalyze the hydrolysis of N-acyl-D-amino acids to produce the corresponding D-amino acids, which are used as intermediates in the synthesis of pesticides, bioactive peptides, and antibiotics; Region: D-aminoacylase; cd01297
335659019543	active site
335659019544	putative substrate binding pocket [chemical binding]; other site
335659019545	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
335659019546	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
335659019547	D-galactonate transporter; Region: 2A0114; TIGR00893
335659019548	putative substrate translocation pore; other site
335659019549	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
335659019550	ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255
335659019551	Walker A/P-loop; other site
335659019552	ATP binding site [chemical binding]; other site
335659019553	Q-loop/lid; other site
335659019554	ABC transporter signature motif; other site
335659019555	Walker B; other site
335659019556	D-loop; other site
335659019557	H-loop/switch region; other site
335659019558	ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577
335659019559	FtsX-like permease family; Region: FtsX; pfam02687
335659019560	Hydroxyneurosporene synthase (CrtC); Region: CrtC; cl12101
335659019561	MAPEG family; Region: MAPEG; pfam01124
335659019562	Periplasmic binding protein; Region: Peripla_BP_6; pfam13458
335659019563	Periplasmic solute-binding domain of active transport proteins that belong to the type I periplasmic binding fold protein family; Region: PBP1_SBP_like_1; cd06327
335659019564	putative ligand binding site [chemical binding]; other site
335659019565	Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841
335659019566	RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730
335659019567	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
335659019568	Maleylacetate reductase is involved in many aromatic compounds degradation pathways of aerobic microbes; Region: MAR; cd08177
335659019569	Alcohol dehydrogenase, class IV [Energy production and conversion]; Region: EutG; COG1454
335659019570	active site
335659019571	dimer interface [polypeptide binding]; other site
335659019572	metal binding site [ion binding]; metal-binding site
335659019573	acyl-CoA synthetase; Provisional; Region: PRK13391
335659019574	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
335659019575	Bacterial Bile acid CoA ligases and similar proteins; Region: BACL_like; cd05929
335659019576	acyl-activating enzyme (AAE) consensus motif; other site
335659019577	acyl-activating enzyme (AAE) consensus motif; other site
335659019578	putative AMP binding site [chemical binding]; other site
335659019579	putative active site [active]
335659019580	putative CoA binding site [chemical binding]; other site
335659019581	CoA binding site [chemical binding]; other site
335659019582	The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_17; cd08503
335659019583	Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496
335659019584	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601
335659019585	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
335659019586	dimer interface [polypeptide binding]; other site
335659019587	conserved gate region; other site
335659019588	putative PBP binding loops; other site
335659019589	ABC-ATPase subunit interface; other site
335659019590	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173
335659019591	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
335659019592	dimer interface [polypeptide binding]; other site
335659019593	conserved gate region; other site
335659019594	putative PBP binding loops; other site
335659019595	ABC-ATPase subunit interface; other site
335659019596	ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444
335659019597	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
335659019598	Walker A/P-loop; other site
335659019599	ATP binding site [chemical binding]; other site
335659019600	Q-loop/lid; other site
335659019601	ABC transporter signature motif; other site
335659019602	Walker B; other site
335659019603	D-loop; other site
335659019604	H-loop/switch region; other site
335659019605	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097
335659019606	dipeptide transporter ATP-binding subunit; Provisional; Region: dppF; PRK11308
335659019607	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
335659019608	Walker A/P-loop; other site
335659019609	ATP binding site [chemical binding]; other site
335659019610	Q-loop/lid; other site
335659019611	ABC transporter signature motif; other site
335659019612	Walker B; other site
335659019613	D-loop; other site
335659019614	H-loop/switch region; other site
335659019615	oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727
335659019616	Acetyl/propionyl-CoA carboxylase, alpha subunit [Lipid metabolism]; Region: COG4770
335659019617	Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289
335659019618	Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786
335659019619	Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; pfam02785
335659019620	The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850
335659019621	carboxyltransferase (CT) interaction site; other site
335659019622	biotinylation site [posttranslational modification]; other site
335659019623	Acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta) [Lipid metabolism]; Region: COG4799
335659019624	Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; cl17345
335659019625	Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; cl17345
335659019626	Prokaryotic protein of unknown function (DUF849); Region: DUF849; pfam05853
335659019627	AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207
335659019628	Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625
335659019629	GST_N family, Saccharomyces cerevisiae GTT1-like subfamily; composed of predominantly uncharacterized proteins with similarity to the S. cerevisiae GST protein, GTT1, and the Schizosaccharomyces pombe GST-III. GSTs are cytosolic dimeric proteins involved...; Region: GST_N_GTT1_like; cd03046
335659019630	putative C-terminal domain interface [polypeptide binding]; other site
335659019631	putative GSH binding site (G-site) [chemical binding]; other site
335659019632	putative dimer interface [polypeptide binding]; other site
335659019633	C-terminal, alpha helical domain of the Glutathione S-transferase family; Region: GST_C_family; cl02776
335659019634	N-terminal domain interface [polypeptide binding]; other site
335659019635	dimer interface [polypeptide binding]; other site
335659019636	substrate binding pocket (H-site) [chemical binding]; other site
335659019637	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
335659019638	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
335659019639	active site
335659019640	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
335659019641	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
335659019642	active site
335659019643	long-chain-fatty-acid--CoA ligase; Validated; Region: PRK06187
335659019644	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
335659019645	Bacterial Bile acid CoA ligases and similar proteins; Region: BACL_like; cd05929
335659019646	acyl-activating enzyme (AAE) consensus motif; other site
335659019647	acyl-activating enzyme (AAE) consensus motif; other site
335659019648	putative AMP binding site [chemical binding]; other site
335659019649	putative active site [active]
335659019650	putative CoA binding site [chemical binding]; other site
335659019651	Type I periplasmic ligand-binding domain of uncharacterized ABC (ATPase Binding Cassette)-type active transport systems that are predicted to be involved in uptake of amino acids, peptides, or inorganic ions; Region: PBP1_ABC_ligand_binding_like_8; cd06343
335659019652	Periplasmic binding protein; Region: Peripla_BP_6; pfam13458
335659019653	putative ligand binding site [chemical binding]; other site
335659019654	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
335659019655	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
335659019656	non-specific DNA binding site [nucleotide binding]; other site
335659019657	salt bridge; other site
335659019658	sequence-specific DNA binding site [nucleotide binding]; other site
335659019659	marine proteobacterial sortase target protein; Region: marine_srt_targ; TIGR03788
335659019660	Vault protein inter-alpha-trypsin domain; Region: VIT; cl02699
335659019661	vWA_interalpha trypsin inhibitor (ITI): ITI is a glycoprotein composed of three polypeptides- two heavy chains and one light chain (bikunin). Bikunin confers the protease-inhibitor function while the heavy chains are involved in rendering stability to...; Region: vWA_interalpha_trypsin_inhibitor; cd01461
335659019662	metal ion-dependent adhesion site (MIDAS); other site
335659019663	Sortase D (SrtD) is a membrane transpeptidase found in gram-positive bacteria that anchors surface proteins to peptidoglycans of the bacterial cell wall envelope. This involves a transpeptidation reaction in which the surface protein substrate is cleaved...; Region: Sortase_D_4; cd05828
335659019664	active site
335659019665	catalytic site [active]
335659019666	Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463
335659019667	WfgS and WfeV are involved in O-antigen biosynthesis; Region: GT_2_WfgS_like; cd06433
335659019668	metal-binding site
335659019669	Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463
335659019670	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
335659019671	active site
335659019672	Acyl-CoA synthetase (NDP forming) [Energy production and conversion]; Region: COG1042
335659019673	CoA binding domain; Region: CoA_binding_2; pfam13380
335659019674	Succinyl-CoA ligase like flavodoxin domain; Region: Succ_CoA_lig; pfam13607
335659019675	ATP-grasp domain; Region: ATP-grasp_5; pfam13549
335659019676	ABC-type transport system involved in resistance to organic solvents, periplasmic component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2C; COG1463
335659019677	mce related protein; Region: MCE; pfam02470
335659019678	Autotransporter-associated beta strand repeat; Region: Autotrns_rpt; pfam12951
335659019679	Autotransporter beta-domain; Region: Autotransporter; smart00869
335659019680	acylamide amidohydrolase; Provisional; Region: amiE; PRK13286
335659019681	aliphatic amidases (class 2 nitrilases); Region: aliphatic_amidase; cd07565
335659019682	multimer interface [polypeptide binding]; other site
335659019683	active site
335659019684	catalytic triad [active]
335659019685	dimer interface [polypeptide binding]; other site
335659019686	putative regulatory protein, FmdB family; Region: CxxC_CxxC_SSSS; TIGR02605
335659019687	Acetamidase/Formamidase family; Region: FmdA_AmdA; pfam03069
335659019688	urea ABC transporter, ATP-binding protein UrtE; Region: urea_trans_UrtE; TIGR03410
335659019689	ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224
335659019690	Walker A/P-loop; other site
335659019691	ATP binding site [chemical binding]; other site
335659019692	Q-loop/lid; other site
335659019693	ABC transporter signature motif; other site
335659019694	Walker B; other site
335659019695	D-loop; other site
335659019696	H-loop/switch region; other site
335659019697	urea ABC transporter, ATP-binding protein UrtD; Region: urea_trans_UrtD; TIGR03411
335659019698	ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219
335659019699	Walker A/P-loop; other site
335659019700	ATP binding site [chemical binding]; other site
335659019701	Q-loop/lid; other site
335659019702	ABC transporter signature motif; other site
335659019703	Walker B; other site
335659019704	D-loop; other site
335659019705	H-loop/switch region; other site
335659019706	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
335659019707	Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581
335659019708	TM-ABC transporter signature motif; other site
335659019709	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
335659019710	Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582
335659019711	TM-ABC transporter signature motif; other site
335659019712	Periplasmic binding protein; Region: Peripla_BP_6; pfam13458
335659019713	Periplasmic component (FmdD) of an active transport system for short-chain amides and urea (FmdDEF); Region: PBP1_FmdD_like; cd06355
335659019714	putative ligand binding site [chemical binding]; other site
335659019715	Solute carrier families 5 and 6-like; solute binding domain; Region: SLC5-6-like_sbd; cl00456
335659019716	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
335659019717	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
335659019718	dimer interface [polypeptide binding]; other site
335659019719	phosphorylation site [posttranslational modification]
335659019720	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
335659019721	ATP binding site [chemical binding]; other site
335659019722	Mg2+ binding site [ion binding]; other site
335659019723	G-X-G motif; other site
335659019724	FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784
335659019725	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
335659019726	active site
335659019727	phosphorylation site [posttranslational modification]
335659019728	intermolecular recognition site; other site
335659019729	dimerization interface [polypeptide binding]; other site
335659019730	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
335659019731	Response regulator receiver domain; Region: Response_reg; pfam00072
335659019732	active site
335659019733	phosphorylation site [posttranslational modification]
335659019734	intermolecular recognition site; other site
335659019735	dimerization interface [polypeptide binding]; other site
335659019736	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
335659019737	DNA binding residues [nucleotide binding]
335659019738	Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072
335659019739	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
335659019740	Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad...; Region: Tryp_SPc; cl00149
335659019741	active site
335659019742	substrate binding sites [chemical binding]; other site
335659019743	epoxide hydrolase N-terminal domain-like phosphatase; Region: HAD-1A3-hyp; TIGR02247
335659019744	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
335659019745	motif II; other site
335659019746	methylthioribose-1-phosphate isomerase; Reviewed; Region: mtnA; PRK05720
335659019747	S-methyl-5-thioribose-1-phosphate isomerase; Region: salvage_mtnA; TIGR00512
335659019748	5'-methylthioadenosine phosphorylase; Provisional; Region: PRK08931
335659019749	acyl carrier protein; Provisional; Region: PRK07081
335659019750	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
335659019751	Acyl-CoA dehydrogenase, N-terminal domain; Region: Acyl-CoA_dh_N; pfam02771
335659019752	Gly_His_Pro_Ser_Thr_tRNA synthetase class II core domain. This domain is the core catalytic domain of tRNA synthetases of the subgroup containing glycyl, histidyl, prolyl, seryl and threonyl tRNA synthetases. It is primarily responsible for ATP-dependent...; Region: Gly_His_Pro_Ser_Thr_tRS_core; cd00670
335659019753	dimer interface [polypeptide binding]; other site
335659019754	motif 1; other site
335659019755	active site
335659019756	motif 2; other site
335659019757	motif 3; other site
335659019758	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182
335659019759	PAS domain; Region: PAS; smart00091
335659019760	PAS fold; Region: PAS_7; pfam12860
335659019761	putative active site [active]
335659019762	heme pocket [chemical binding]; other site
335659019763	PAS domain; Region: PAS; smart00091
335659019764	PAS fold; Region: PAS_7; pfam12860
335659019765	PAS fold; Region: PAS_7; pfam12860
335659019766	PAS domain; Region: PAS; smart00091
335659019767	PAS fold; Region: PAS_7; pfam12860
335659019768	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
335659019769	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
335659019770	metal binding site [ion binding]; metal-binding site
335659019771	active site
335659019772	I-site; other site
335659019773	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
335659019774	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3181
335659019775	Tripartite tricarboxylate transporter TctB family; Region: TctB; pfam07331
335659019776	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3333
335659019777	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
335659019778	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
335659019779	metal binding site [ion binding]; metal-binding site
335659019780	active site
335659019781	I-site; other site
335659019782	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
335659019783	Ribosomal protein L32 [Translation, ribosomal structure and biogenesis]; Region: RpmF; COG0333
335659019784	Transglycosylase; Region: Transgly; cl17702
335659019785	Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142
335659019786	Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685
335659019787	substrate binding pocket [chemical binding]; other site
335659019788	chain length determination region; other site
335659019789	substrate-Mg2+ binding site; other site
335659019790	catalytic residues [active]
335659019791	aspartate-rich region 1; other site
335659019792	active site lid residues [active]
335659019793	aspartate-rich region 2; other site
335659019794	Protein of unknown function (DUF1345); Region: DUF1345; pfam07077
335659019795	Caspase domain; Region: Peptidase_C14; pfam00656
335659019796	Uncharacterized conserved protein [Function unknown]; Region: COG3791
335659019797	Putative lumazine-binding; Region: Lumazine_bd_2; pfam12893
335659019798	beta-lactamase TEM; Provisional; Region: PRK15442
335659019799	Beta-lactamase enzyme family; Region: Beta-lactamase2; pfam13354
335659019800	Na+/H+ antiporter, bacterial form; Region: a_cpa1; TIGR00831
335659019801	N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860
335659019802	N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696
335659019803	active site
335659019804	metal binding site [ion binding]; metal-binding site
335659019805	Clavaminic acid synthetase (CAS) -like;  CAS is a trifunctional Fe(II)/ 2-oxoglutarate (2OG) oxygenase carrying out three reactions in the biosynthesis of clavulanic acid, an inhibitor of class A serine beta-lactamases. In general, Fe(II)-2OG oxygenases...; Region: CAS_like; cl00184
335659019806	Probable taurine catabolism dioxygenase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: TauD; COG2175
335659019807	4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Reviewed; Region: ispG; PRK00366
335659019808	4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694
335659019809	4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694
335659019810	Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697
335659019811	EamA-like transporter family; Region: EamA; pfam00892
335659019812	EamA-like transporter family; Region: EamA; pfam00892
335659019813	Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153
335659019814	metal binding site 2 [ion binding]; metal-binding site
335659019815	putative DNA binding helix; other site
335659019816	metal binding site 1 [ion binding]; metal-binding site
335659019817	dimer interface [polypeptide binding]; other site
335659019818	structural Zn2+ binding site [ion binding]; other site
335659019819	Transcriptional regulators [Transcription]; Region: MarR; COG1846
335659019820	MarR family; Region: MarR; pfam01047
335659019821	Multidrug resistance efflux pump [Defense mechanisms]; Region: EmrA; COG1566
335659019822	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
335659019823	HlyD family secretion protein; Region: HlyD_3; pfam13437
335659019824	drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711
335659019825	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
335659019826	putative substrate translocation pore; other site
335659019827	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
335659019828	Ecdysteroid kinase; Region: EcKinase; cl17738
335659019829	Apo-citrate lyase phosphoribosyl-dephospho-CoA transferase; Region: CitX; cl01498
335659019830	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
335659019831	dimerization interface [polypeptide binding]; other site
335659019832	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
335659019833	Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283
335659019834	dimer interface [polypeptide binding]; other site
335659019835	putative CheW interface [polypeptide binding]; other site
335659019836	Protocatechuate 3,4-dioxygenase beta subunit [Secondary metabolites biosynthesis, transport, and catabolism]; Region: PcaH; COG3485
335659019837	Protocatechuate 3,4-dioxygenase (3,4-PCD) , alpha subunit. 3,4-PCD catalyzes the oxidative ring cleavage of 3,4-dihydroxybenzoate to produce beta-carboxy-cis,cis-muconate. 3,4-PCDs are large aggregates of 12 protomers, each composed of an alpha- and...; Region: 3,4-PCD_alpha; cd03463
335659019838	heterodimer interface [polypeptide binding]; other site
335659019839	active site
335659019840	Protocatechuate 3,4-dioxygenase (3,4-PCD) , beta subunit. 3,4-PCD catalyzes the oxidative ring cleavage of 3,4-dihydroxybenzoate to produce beta-carboxy-cis,cis-muconate. 3,4-PCDs are large aggregates of 12 protomers, each composed of an alpha- and...; Region: 3,4-PCD_beta; cd03464
335659019841	heterodimer interface [polypeptide binding]; other site
335659019842	multimer interface [polypeptide binding]; other site
335659019843	protocatechuate 3,4-dioxygenase, beta subunit; Region: protocat_beta; TIGR02422
335659019844	active site
335659019845	beta-ketoadipyl CoA thiolase; Validated; Region: PRK09050
335659019846	Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751
335659019847	dimer interface [polypeptide binding]; other site
335659019848	active site
335659019849	DNA mismatch repair protein MutS; Provisional; Region: PRK05399
335659019850	MutS domain I; Region: MutS_I; pfam01624
335659019851	MutS domain II; Region: MutS_II; pfam05188
335659019852	MutS domain III; Region: MutS_III; pfam05192
335659019853	ATP-binding cassette domain of MutS1 homolog; Region: ABC_MutS1; cd03284
335659019854	Walker A/P-loop; other site
335659019855	ATP binding site [chemical binding]; other site
335659019856	Q-loop/lid; other site
335659019857	ABC transporter signature motif; other site
335659019858	Walker B; other site
335659019859	D-loop; other site
335659019860	H-loop/switch region; other site
335659019861	PAS domain; Region: PAS_9; pfam13426
335659019862	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
335659019863	PAS domain; Region: PAS_9; pfam13426
335659019864	putative active site [active]
335659019865	heme pocket [chemical binding]; other site
335659019866	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
335659019867	PAS domain; Region: PAS_9; pfam13426
335659019868	putative active site [active]
335659019869	heme pocket [chemical binding]; other site
335659019870	Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283
335659019871	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
335659019872	dimer interface [polypeptide binding]; other site
335659019873	putative CheW interface [polypeptide binding]; other site
335659019874	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
335659019875	FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202
335659019876	putative active site [active]
335659019877	heme pocket [chemical binding]; other site
335659019878	FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202
335659019879	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
335659019880	putative active site [active]
335659019881	heme pocket [chemical binding]; other site
335659019882	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
335659019883	putative active site [active]
335659019884	heme pocket [chemical binding]; other site
335659019885	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
335659019886	Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283
335659019887	dimer interface [polypeptide binding]; other site
335659019888	putative CheW interface [polypeptide binding]; other site
335659019889	OsmC-like protein; Region: OsmC; pfam02566
335659019890	PII uridylyl-transferase; Provisional; Region: PRK05092
335659019891	Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401
335659019892	metal binding triad; other site
335659019893	GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335
335659019894	HD domain; Region: HD; pfam01966
335659019895	ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141
335659019896	C-terminal ACT domains of the bacterial signal-transducing uridylyltransferase /uridylyl-removing (UUR) enzyme, GlnD and related domains; Region: ACT_ACR-UUR-like_2; cd04899
335659019897	Methylated DNA-protein cysteine methyltransferase [DNA replication, recombination, and repair]; Region: Ada; COG0350
335659019898	The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445
335659019899	DNA binding site [nucleotide binding]
335659019900	active site
335659019901	Protein of unknown function (DUF1304); Region: DUF1304; pfam06993
335659019902	Type I periplasmic ligand-binding domain of uncharacterized ABC (ATPase Binding Cassette)-type active transport systems that are predicted to be involved in uptake of amino acids, peptides, or inorganic ions; Region: PBP1_ABC_ligand_binding_like_8; cd06343
335659019903	Periplasmic binding protein; Region: Peripla_BP_6; pfam13458
335659019904	putative ligand binding site [chemical binding]; other site
335659019905	Type I periplasmic ligand-binding domain of uncharacterized ABC (ATPase Binding Cassette)-type active transport systems that are predicted to be involved in uptake of amino acids, peptides, or inorganic ions; Region: PBP1_ABC_ligand_binding_like_8; cd06343
335659019906	Periplasmic binding protein; Region: Peripla_BP_6; pfam13458
335659019907	putative ligand binding site [chemical binding]; other site
335659019908	Protein of unknown function (DUF1330); Region: DUF1330; cl02288
335659019909	Transglycosylase; Region: Transgly; pfam00912
335659019910	penicillin-binding protein, 1A family; Region: PBP_1a_fam; TIGR02074
335659019911	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905
335659019912	Protein of unknown function DUF45; Region: DUF45; pfam01863
335659019913	Poly-beta-hydroxyalkanoate depolymerase [Lipid metabolism]; Region: DepA; COG4553
335659019914	PHB de-polymerase C-terminus; Region: PHB_depo_C; pfam06850
335659019915	ABC-2 type transporter; Region: ABC2_membrane; pfam01061
335659019916	ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842
335659019917	ABC-type Na+ transport system, ATPase component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatA; COG4555
335659019918	ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230
335659019919	Walker A/P-loop; other site
335659019920	ATP binding site [chemical binding]; other site
335659019921	Q-loop/lid; other site
335659019922	ABC transporter signature motif; other site
335659019923	Walker B; other site
335659019924	D-loop; other site
335659019925	H-loop/switch region; other site
335659019926	Domain of unknown function (DUF4118); Region: DUF4118; pfam13493
335659019927	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
335659019928	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
335659019929	dimer interface [polypeptide binding]; other site
335659019930	phosphorylation site [posttranslational modification]
335659019931	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
335659019932	ATP binding site [chemical binding]; other site
335659019933	Mg2+ binding site [ion binding]; other site
335659019934	G-X-G motif; other site
335659019935	Response regulator consisting of a CheY-like receiver domain and a Fis-type HTH domain [Signal transduction mechanisms / Transcription]; Region: COG4567
335659019936	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
335659019937	active site
335659019938	phosphorylation site [posttranslational modification]
335659019939	intermolecular recognition site; other site
335659019940	dimerization interface [polypeptide binding]; other site
335659019941	PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556
335659019942	Protein of unknown function (DUF1052); Region: DUF1052; pfam06319
335659019943	trehalose synthase; Region: treS_nterm; TIGR02456
335659019944	Alpha amylase catalytic domain found in Trehalose synthetase; Region: AmyAc_TreS; cd11334
335659019945	active site
335659019946	catalytic site [active]
335659019947	alpha,alpha-phosphotrehalase; Region: trehalose_treC; TIGR02403
335659019948	Alpha amylase catalytic domain found in oligo-1,6-glucosidase (also called isomaltase; sucrase-isomaltase; alpha-limit dextrinase) and related proteins; Region: AmyAc_OligoGlu_like; cd11331
335659019949	active site
335659019950	catalytic site [active]
335659019951	Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491
335659019952	esterase, PHB depolymerase family; Region: esterase_phb; TIGR01840
335659019953	Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326
335659019954	Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892
335659019955	Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases [Energy production and conversion]; Region: COG2141
335659019956	Cytochrome P450; Region: p450; cl12078
335659019957	Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124
335659019958	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
335659019959	3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK07231
335659019960	NAD(P) binding site [chemical binding]; other site
335659019961	active site
335659019962	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920
335659019963	HWE histidine kinase; Region: HWE_HK; pfam07536
335659019964	PAS fold; Region: PAS_4; pfam08448
335659019965	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
335659019966	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
335659019967	metal binding site [ion binding]; metal-binding site
335659019968	active site
335659019969	I-site; other site
335659019970	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
335659019971	PAS fold; Region: PAS; pfam00989
335659019972	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
335659019973	putative active site [active]
335659019974	heme pocket [chemical binding]; other site
335659019975	Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204
335659019976	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
335659019977	Walker B motif; other site
335659019978	arginine finger; other site
335659019979	Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954
335659019980	Periplasmic binding protein; Region: Peripla_BP_6; pfam13458
335659019981	Periplasmic solute-binding domain of active transport proteins found in gram-negative and gram-positive bacteria; Region: PBP1_SBP_like_2; cd06328
335659019982	putative ligand binding site [chemical binding]; other site
335659019983	ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411
335659019984	ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219
335659019985	Walker A/P-loop; other site
335659019986	ATP binding site [chemical binding]; other site
335659019987	Q-loop/lid; other site
335659019988	ABC transporter signature motif; other site
335659019989	Walker B; other site
335659019990	D-loop; other site
335659019991	H-loop/switch region; other site
335659019992	ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410
335659019993	ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224
335659019994	Walker A/P-loop; other site
335659019995	ATP binding site [chemical binding]; other site
335659019996	Q-loop/lid; other site
335659019997	ABC transporter signature motif; other site
335659019998	Walker B; other site
335659019999	D-loop; other site
335659020000	H-loop/switch region; other site
335659020001	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
335659020002	Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582
335659020003	TM-ABC transporter signature motif; other site
335659020004	ABC-type branched-chain amino acid transport system, permease component [Amino acid transport and metabolism]; Region: LivM; COG4177
335659020005	Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581
335659020006	TM-ABC transporter signature motif; other site
335659020007	PAS domain; Region: PAS; smart00091
335659020008	PAS fold; Region: PAS_7; pfam12860
335659020009	PAS fold; Region: PAS_4; pfam08448
335659020010	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
335659020011	putative active site [active]
335659020012	heme pocket [chemical binding]; other site
335659020013	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
335659020014	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
335659020015	metal binding site [ion binding]; metal-binding site
335659020016	active site
335659020017	I-site; other site
335659020018	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
335659020019	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
335659020020	PAS domain; Region: PAS_9; pfam13426
335659020021	putative active site [active]
335659020022	heme pocket [chemical binding]; other site
335659020023	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
335659020024	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
335659020025	metal binding site [ion binding]; metal-binding site
335659020026	active site
335659020027	I-site; other site
335659020028	DNA Polymerase IV/Kappa; Region: PolY_Pol_IV_kappa; cd03586
335659020029	active site
335659020030	DNA polymerase IV; Validated; Region: PRK02406
335659020031	DNA binding site [nucleotide binding]
335659020032	Protein of unknown function (DUF1330); Region: DUF1330; cl02288
335659020033	Methyladenine glycosylase; Region: Adenine_glyco; cl01059
335659020034	metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995
335659020035	Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149
335659020036	active site
335659020037	metal binding site [ion binding]; metal-binding site
335659020038	cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664
335659020039	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
335659020040	ligand binding site [chemical binding]; other site
335659020041	Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670
335659020042	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182
335659020043	undecaprenyl pyrophosphate synthase; Provisional; Region: PRK14839
335659020044	Putative undecaprenyl diphosphate synthase; Region: Prenyltransf; pfam01255
335659020045	catalytic residue [active]
335659020046	putative FPP diphosphate  binding site; other site
335659020047	putative FPP binding hydrophobic cleft; other site
335659020048	dimer interface [polypeptide binding]; other site
335659020049	putative IPP diphosphate binding site; other site
335659020050	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
335659020051	putative DNA binding site [nucleotide binding]; other site
335659020052	dimerization interface [polypeptide binding]; other site
335659020053	putative Zn2+ binding site [ion binding]; other site
335659020054	Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365
335659020055	Protein of unknown function (DUF3551); Region: DUF3551; pfam12071
335659020056	Tripartite tricarboxylate transporter family receptor; Region: TctC; cl17792
335659020057	This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_2; cd07253
335659020058	dimer interface [polypeptide binding]; other site
335659020059	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
335659020060	metal binding site [ion binding]; metal-binding site
335659020061	Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318
335659020062	Uncharacterized subfamily of fatty acid CoA ligase (FACL); Region: FACL_DitJ_like; cd05934
335659020063	acyl-activating enzyme (AAE) consensus motif; other site
335659020064	putative AMP binding site [chemical binding]; other site
335659020065	putative active site [active]
335659020066	putative CoA binding site [chemical binding]; other site
335659020067	c-di-GMP phosphodiesterase class II (HD-GYP domain) [Signal transduction mechanisms]; Region: COG2206
335659020068	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
335659020069	Zn2+ binding site [ion binding]; other site
335659020070	Mg2+ binding site [ion binding]; other site
335659020071	Aerobic-type carbon monoxide dehydrogenase, large subunit CoxL/CutL homologs [Energy production and conversion]; Region: CoxL; COG1529
335659020072	Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738
335659020073	Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; smart01008
335659020074	Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738
335659020075	Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738
335659020076	Aerobic-type carbon monoxide dehydrogenase, small subunit CoxS/CutS homologs [Energy production and conversion]; Region: CoxS; COG2080
335659020077	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
335659020078	catalytic loop [active]
335659020079	iron binding site [ion binding]; other site
335659020080	[2Fe-2S] binding domain; Region: Fer2_2; pfam01799
335659020081	3-oxoadipate enol-lactonase; Region: protocat_pcaD; TIGR02427
335659020082	homoserine O-acetyltransferase; Provisional; Region: metX; cl17114
335659020083	Dienelactone hydrolase and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG0412
335659020084	Polysaccharide biosynthesis/export protein; Region: Poly_export; pfam02563
335659020085	putative polysaccharide export protein, PEP-CTERM sytem-associated; Region: pepcterm_export; TIGR03027
335659020086	SLBB domain; Region: SLBB; pfam10531
335659020087	methionine sulfoxide reductase A; Provisional; Region: PRK00058
335659020088	30S ribosomal protein S20; Reviewed; Region: rpsT; PRK00239