-- dump date 20140619_010019 -- class Genbank::misc_feature -- table misc_feature_note -- id note 358681000001 chromosomal replication initiation protein; Reviewed; Region: dnaA; PRK00149 358681000002 DnaA N-terminal domain; Region: DnaA_N; pfam11638 358681000003 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 358681000004 Walker A motif; other site 358681000005 ATP binding site [chemical binding]; other site 358681000006 Walker B motif; other site 358681000007 arginine finger; other site 358681000008 C-terminal domain of bacterial DnaA proteins. The DNA-binding C-terminal domain of DnaA contains a helix-turn-helix motif that specifically interacts with the DnaA box, a 9-mer motif that occurs repetitively in the replication origin oriC. Multiple...; Region: Bac_DnaA_C; cd06571 358681000009 DnaA box-binding interface [nucleotide binding]; other site 358681000010 DNA polymerase III subunit beta; Validated; Region: PRK05643 358681000011 Beta clamp domain. The beta subunit (processivity factor) of DNA polymerase III holoenzyme, refered to as the beta clamp, forms a ring shaped dimer that encircles dsDNA (sliding clamp) in bacteria. The beta-clamp is structurally similar to the trimeric...; Region: beta_clamp; cd00140 358681000012 putative DNA binding surface [nucleotide binding]; other site 358681000013 dimer interface [polypeptide binding]; other site 358681000014 beta-clamp/clamp loader binding surface; other site 358681000015 beta-clamp/translesion DNA polymerase binding surface; other site 358681000016 S4 domain; Region: S4_2; pfam13275 358681000017 recombination protein F; Reviewed; Region: recF; PRK00064 358681000018 ATP-binding cassette domain of RecF; Region: ABC_RecF; cd03242 358681000019 Walker A/P-loop; other site 358681000020 ATP binding site [chemical binding]; other site 358681000021 Q-loop/lid; other site 358681000022 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 358681000023 ABC transporter signature motif; other site 358681000024 Walker B; other site 358681000025 D-loop; other site 358681000026 H-loop/switch region; other site 358681000027 DNA gyrase subunit B; Validated; Region: gyrB; PRK05644 358681000028 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 358681000029 Mg2+ binding site [ion binding]; other site 358681000030 G-X-G motif; other site 358681000031 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822 358681000032 anchoring element; other site 358681000033 dimer interface [polypeptide binding]; other site 358681000034 ATP binding site [chemical binding]; other site 358681000035 TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of the...; Region: TOPRIM_TopoIIA_GyrB; cd03366 358681000036 active site 358681000037 putative metal-binding site [ion binding]; other site 358681000038 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 358681000039 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 358681000040 HAMP domain; Region: HAMP; pfam00672 358681000041 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 358681000042 dimer interface [polypeptide binding]; other site 358681000043 phosphorylation site [posttranslational modification] 358681000044 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 358681000045 ATP binding site [chemical binding]; other site 358681000046 Mg2+ binding site [ion binding]; other site 358681000047 G-X-G motif; other site 358681000048 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 358681000049 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 358681000050 active site 358681000051 phosphorylation site [posttranslational modification] 358681000052 intermolecular recognition site; other site 358681000053 dimerization interface [polypeptide binding]; other site 358681000054 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 358681000055 DNA binding site [nucleotide binding] 358681000056 DNA gyrase subunit A; Validated; Region: PRK05560 358681000057 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187 358681000058 CAP-like domain; other site 358681000059 active site 358681000060 primary dimer interface [polypeptide binding]; other site 358681000061 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 358681000062 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 358681000063 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 358681000064 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 358681000065 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 358681000066 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 358681000067 c-di-GMP phosphodiesterase class II (HD-GYP domain) [Signal transduction mechanisms]; Region: COG2206 358681000068 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 358681000069 Zn2+ binding site [ion binding]; other site 358681000070 Mg2+ binding site [ion binding]; other site 358681000071 YaaC-like Protein; Region: YaaC; pfam14175 358681000072 inosine 5'-monophosphate dehydrogenase; Reviewed; Region: PRK05567 358681000073 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 358681000074 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in the inosine 5' monophosphate dehydrogenase (IMPDH) protein. IMPDH is an essential enzyme that catalyzes the first step unique to GTP synthesis, playing a...; Region: CBS_pair_IMPDH; cd04601 358681000075 IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381 358681000076 active site 358681000077 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872 358681000078 D-alanyl-D-alanine carboxypeptidase [Cell envelope biogenesis, outer membrane]; Region: DacC; COG1686 358681000079 Penicillin-binding protein 5, C-terminal domain; Region: PBP5_C; smart00936 358681000080 pyridoxal 5'-phosphate synthase, synthase subunit Pdx1; Region: TIGR00343 358681000081 PdxS is a subunit of the pyridoxal 5'-phosphate (PLP) synthase, an important enzyme in deoxyxylulose 5-phosphate (DXP)-independent pathway for de novo biosynthesis of PLP, present in some eubacteria, in archaea, fungi, plants, plasmodia, and some...; Region: pdxS; cd04727 358681000082 active site 358681000083 multimer interface [polypeptide binding]; other site 358681000084 Glutamine Amidotransferase (GATase_I) involved in pyridoxine biosynthesis; Region: GATase1_PB; cd01749 358681000085 Glutamine amidotransferase [Amino acid transport and metabolism]; Region: HisH; COG0118 358681000086 predicted active site [active] 358681000087 catalytic triad [active] 358681000088 seryl-tRNA synthetase; Provisional; Region: PRK05431 358681000089 Seryl-tRNA synthetase N-terminal domain; Region: Seryl_tRNA_N; pfam02403 358681000090 Seryl-tRNA synthetase (SerRS) class II core catalytic domain. SerRS is responsible for the attachment of serine to the 3' OH group of ribose of the appropriate tRNA. This domain It is primarily responsible for ATP-dependent formation of the enzyme...; Region: SerRS_core; cd00770 358681000091 dimer interface [polypeptide binding]; other site 358681000092 active site 358681000093 motif 1; other site 358681000094 motif 2; other site 358681000095 motif 3; other site 358681000096 malate synthase A; Region: malate_syn_A; TIGR01344 358681000097 Malate synthase A (MSA), present in some bacteria, plants and fungi. Prokaryotic MSAs tend to be monomeric, whereas eukaryotic enzymes are homomultimers. In general, malate synthase catalyzes the Claisen condensation of glyoxylate and acetyl-CoA to...; Region: malate_synt_A; cd00727 358681000098 active site 358681000099 isocitrate lyase; Provisional; Region: PRK15063 358681000100 Members of the ICL/PEPM enzyme family catalyze either P-C or C-C bond formation/cleavage. Known members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate hydrolase (OAH), isocitrate...; Region: ICL_PEPM; cd00377 358681000101 tetramer interface [polypeptide binding]; other site 358681000102 active site 358681000103 Mg2+/Mn2+ binding site [ion binding]; other site 358681000104 ABC-type Fe3+ transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: AfuA; COG1840 358681000105 Spermidine/putrescine-binding periplasmic protein [Amino acid transport and metabolism]; Region: PotD; COG0687 358681000106 Uncharacterized proteins of the AP superfamily [General function prediction only]; Region: COG1524 358681000107 BPG-independent PGAM N-terminus (iPGM_N); Region: iPGM_N; cl17463 358681000108 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 358681000109 dimer interface [polypeptide binding]; other site 358681000110 conserved gate region; other site 358681000111 ABC-ATPase subunit interface; other site 358681000112 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 358681000113 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 358681000114 dimer interface [polypeptide binding]; other site 358681000115 conserved gate region; other site 358681000116 putative PBP binding loops; other site 358681000117 ABC-ATPase subunit interface; other site 358681000118 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 358681000119 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 358681000120 Walker A/P-loop; other site 358681000121 ATP binding site [chemical binding]; other site 358681000122 Q-loop/lid; other site 358681000123 ABC transporter signature motif; other site 358681000124 Walker B; other site 358681000125 D-loop; other site 358681000126 H-loop/switch region; other site 358681000127 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 358681000128 DeoR-like helix-turn-helix domain; Region: HTH_DeoR; cl17531 358681000129 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 358681000130 histidinol-phosphatase; Validated; Region: PRK06740 358681000131 Polymerase and Histidinol Phosphatase domain of Histidinol phosphate phosphatase of Hisj like; Region: PHP_HisPPase_Hisj_like; cd12110 358681000132 dimer interface [polypeptide binding]; other site 358681000133 active site 358681000134 phosphoenolpyruvate synthase; Validated; Region: PRK06241 358681000135 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 358681000136 homotrimer interaction site [polypeptide binding]; other site 358681000137 putative active site [active] 358681000138 Nucleoside permease [Nucleotide transport and metabolism]; Region: NupC; COG1972 358681000139 Na+ dependent nucleoside transporter N-terminus; Region: Nucleos_tra2_N; pfam01773 358681000140 Nucleoside recognition; Region: Gate; pfam07670 358681000141 Na+ dependent nucleoside transporter C-terminus; Region: Nucleos_tra2_C; pfam07662 358681000142 DoxX; Region: DoxX; pfam07681 358681000143 Predicted transcriptional regulators [Transcription]; Region: COG1733 358681000144 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 358681000145 dimerization interface [polypeptide binding]; other site 358681000146 putative DNA binding site [nucleotide binding]; other site 358681000147 putative Zn2+ binding site [ion binding]; other site 358681000148 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 358681000149 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 358681000150 non-specific DNA binding site [nucleotide binding]; other site 358681000151 salt bridge; other site 358681000152 sequence-specific DNA binding site [nucleotide binding]; other site 358681000153 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 358681000154 non-specific DNA binding site [nucleotide binding]; other site 358681000155 salt bridge; other site 358681000156 sequence-specific DNA binding site [nucleotide binding]; other site 358681000157 PTS system, N-acetylglucosamine-specific IIBC component; Region: PTS-II-BC-nag; TIGR01998 358681000158 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 358681000159 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 358681000160 active site turn [active] 358681000161 phosphorylation site [posttranslational modification] 358681000162 Phosphoenolpyruvate-protein kinase (PTS system EI component in bacteria) [Carbohydrate transport and metabolism]; Region: PtsA; COG1080 358681000163 PEP-utilising enzyme, N-terminal; Region: PEP-utilisers_N; pfam05524 358681000164 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 358681000165 PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896 358681000166 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367 358681000167 dimerization domain swap beta strand [polypeptide binding]; other site 358681000168 regulatory protein interface [polypeptide binding]; other site 358681000169 active site 358681000170 regulatory phosphorylation site [posttranslational modification]; other site 358681000171 Phosphotransferase system IIA components [Carbohydrate transport and metabolism]; Region: NagE; COG2190 358681000172 HPr interaction site; other site 358681000173 glycerol kinase (GK) interaction site [polypeptide binding]; other site 358681000174 active site 358681000175 phosphorylation site [posttranslational modification] 358681000176 transcriptional antiterminator BglG; Provisional; Region: PRK09772 358681000177 CAT RNA binding domain; Region: CAT_RBD; smart01061 358681000178 PRD domain; Region: PRD; pfam00874 358681000179 PRD domain; Region: PRD; pfam00874 358681000180 Protein of unknown function (DUF458); Region: DUF458; cl00861 358681000181 Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285 358681000182 nucleoside/Zn binding site; other site 358681000183 dimer interface [polypeptide binding]; other site 358681000184 catalytic motif [active] 358681000185 16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187 358681000186 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 358681000187 RNA binding surface [nucleotide binding]; other site 358681000188 Pseudouridine synthase, Escherichia coli RsuA like; Region: PseudoU_synth_RsuA; cd02553 358681000189 active site 358681000190 uracil binding [chemical binding]; other site 358681000191 Four helix bundle sensory module for signal transduction; Region: 4HB_MCP_1; pfam12729 358681000192 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 358681000193 dimerization interface [polypeptide binding]; other site 358681000194 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 358681000195 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 358681000196 dimer interface [polypeptide binding]; other site 358681000197 putative CheW interface [polypeptide binding]; other site 358681000198 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 358681000199 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 358681000200 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 358681000201 DNA binding residues [nucleotide binding] 358681000202 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 358681000203 Domain of unknown function (DUF4275); Region: DUF4275; pfam14101 358681000204 SirA, YedF, and YeeD. Two-layered alpha/beta sandwich domain. SirA (also known as UvrY, and YhhP) belongs to a family of bacterial two-component response regulators that controls secondary metabolism and virulence. The other member of this...; Region: SirA_YedF_YeeD; cd00291 358681000205 CPxP motif; other site 358681000206 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 358681000207 active site residue [active] 358681000208 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cl00125 358681000209 active site residue [active] 358681000210 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 358681000211 SirA, YedF, and YeeD. Two-layered alpha/beta sandwich domain. SirA (also known as UvrY, and YhhP) belongs to a family of bacterial two-component response regulators that controls secondary metabolism and virulence. The other member of this...; Region: SirA_YedF_YeeD; cd00291 358681000212 CPxP motif; other site 358681000213 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 358681000214 DsrE/DsrF/DrsH-like family; Region: DrsE_2; pfam13686 358681000215 Uncharacterized protein YrkD from Bacillus subtilis and related domains; this domain superfamily was previously known as part of DUF156; Region: BsYrkD-like_DUF156; cd10155 358681000216 putative homodimer interface [polypeptide binding]; other site 358681000217 putative homotetramer interface [polypeptide binding]; other site 358681000218 putative metal binding site [ion binding]; other site 358681000219 putative homodimer-homodimer interface [polypeptide binding]; other site 358681000220 putative allosteric switch controlling residues; other site 358681000221 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 358681000222 active site residue [active] 358681000223 biliverdin IX beta reductase (BVR-B, aka flavin reductase)-like proteins; atypical (a) SDRs; Region: BVR-B_like_SDR_a; cd05244 358681000224 NADH(P)-binding; Region: NAD_binding_10; pfam13460 358681000225 NAD binding site [chemical binding]; other site 358681000226 substrate binding site [chemical binding]; other site 358681000227 putative active site [active] 358681000228 Tic20-like protein; Region: Tic20; pfam09685 358681000229 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 358681000230 S-adenosylmethionine binding site [chemical binding]; other site 358681000231 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 358681000232 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 358681000233 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 358681000234 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 358681000235 dimerization interface [polypeptide binding]; other site 358681000236 c-di-GMP phosphodiesterase class II (HD-GYP domain) [Signal transduction mechanisms]; Region: COG2206 358681000237 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 358681000238 Zn2+ binding site [ion binding]; other site 358681000239 Mg2+ binding site [ion binding]; other site 358681000240 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 358681000241 FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202 358681000242 putative active site [active] 358681000243 heme pocket [chemical binding]; other site 358681000244 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 358681000245 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 358681000246 putative active site [active] 358681000247 heme pocket [chemical binding]; other site 358681000248 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 358681000249 dimer interface [polypeptide binding]; other site 358681000250 phosphorylation site [posttranslational modification] 358681000251 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 358681000252 ATP binding site [chemical binding]; other site 358681000253 Mg2+ binding site [ion binding]; other site 358681000254 G-X-G motif; other site 358681000255 DNA polymerase III subunits gamma and tau; Validated; Region: PRK05563 358681000256 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 358681000257 Walker A motif; other site 358681000258 ATP binding site [chemical binding]; other site 358681000259 Walker B motif; other site 358681000260 arginine finger; other site 358681000261 DNA polymerase III subunits gamma and tau domain III; Region: DNA_pol3_gamma3; pfam12169 358681000262 hypothetical protein; Validated; Region: PRK00153 358681000263 recombination protein RecR; Reviewed; Region: recR; PRK00076 358681000264 RecR protein; Region: RecR; pfam02132 358681000265 TOPRIM_recR: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in Escherichia coli RecR. RecR participates in the RecFOR pathway of homologous recombinational repair in prokaryotes. This pathway provides a...; Region: TOPRIM_recR; cd01025 358681000266 putative active site [active] 358681000267 putative metal-binding site [ion binding]; other site 358681000268 tetramer interface [polypeptide binding]; other site 358681000269 Ligand-binding SRPBCC domain of an uncharacterized subfamily of proteins; Region: SRPBCC_3; cd07820 358681000270 putative hydrophobic ligand binding site [chemical binding]; other site 358681000271 CAAX protease self-immunity; Region: Abi; pfam02517 358681000272 Protein of unknown function (DUF2508); Region: DUF2508; pfam10704 358681000273 SigmaK-factor processing regulatory protein BofA; Region: BofA; pfam07441 358681000274 UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984 358681000275 UDP-glucose/GDP-mannose dehydrogenase family, UDP binding domain; Region: UDPG_MGDP_dh_C; cl17747 358681000276 Inhibitor of sigma-G Gin; Region: Gin; pfam10764 358681000277 Arginine/lysine/ornithine decarboxylases [Amino acid transport and metabolism]; Region: LdcC; COG1982 358681000278 Ornithine decarboxylase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to ornithine decarboxylase (ODC), arginine decarboxylase (ADC) and lysine...; Region: Orn_deC_like; cd00615 358681000279 homodimer interface [polypeptide binding]; other site 358681000280 pyridoxal 5'-phosphate binding site [chemical binding]; other site 358681000281 catalytic residue [active] 358681000282 Orn/Lys/Arg decarboxylase, C-terminal domain; Region: OKR_DC_1_C; pfam03711 358681000283 thymidylate kinase; Validated; Region: tmk; PRK00698 358681000284 Thymidine monophosphate kinase (TMPK), also known as thymidylate kinase, catalyzes the phosphorylation of thymidine monophosphate (TMP) to thymidine diphosphate (TDP) utilizing ATP as its preferred phophoryl donor. TMPK represents the rate-limiting step...; Region: TMPK; cd01672 358681000285 TMP-binding site; other site 358681000286 ATP-binding site [chemical binding]; other site 358681000287 Protein of unknown function (DUF970); Region: DUF970; pfam06153 358681000288 Protein of unknown function (DUF327); Region: DUF327; pfam03885 358681000289 DNA polymerase III subunit delta'; Validated; Region: PRK08058 358681000290 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189 358681000291 DNA polymerase III subunit delta'; Validated; Region: PRK08485 358681000292 Uncharacterized homolog of PSP1 [Function unknown]; Region: COG1774 358681000293 DNA replication intiation control protein YabA; Reviewed; Region: PRK13169 358681000294 Predicted O-methyltransferase [General function prediction only]; Region: COG4123 358681000295 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 358681000296 S-adenosylmethionine binding site [chemical binding]; other site 358681000297 The GIY-YIG domain of uncharacterized protein family UPF0213 related to structure-specific endonuclease SLX1; Region: GIY-YIG_UPF0213; cd10456 358681000298 GIY-YIG motif/motif A; other site 358681000299 putative active site [active] 358681000300 putative metal binding site [ion binding]; other site 358681000301 Predicted methyltransferases [General function prediction only]; Region: COG0313 358681000302 Ribosomal RNA small subunit methyltransferase I, also known as rRNA (cytidine-2'-O-)-methyltransferase RsmI; Region: RsmI; cd11648 358681000303 putative SAM binding site [chemical binding]; other site 358681000304 putative homodimer interface [polypeptide binding]; other site 358681000305 Methyltransferase domain; Region: Methyltransf_31; pfam13847 358681000306 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 358681000307 S-adenosylmethionine binding site [chemical binding]; other site 358681000308 SpoVT / AbrB like domain; Region: SpoVT_AbrB; smart00966 358681000309 methionyl-tRNA synthetase; Reviewed; Region: PRK12267 358681000310 catalytic core domain of methioninyl-tRNA synthetases; Region: MetRS_core; cd00814 358681000311 HIGH motif; other site 358681000312 active site 358681000313 KMSKS motif; other site 358681000314 Anticodon-binding domain of methionyl tRNA synthetases; Region: Anticodon_Ia_Met; cd07957 358681000315 tRNA binding surface [nucleotide binding]; other site 358681000316 anticodon binding site; other site 358681000317 tRNA-binding-domain-containing Escherichia coli methionyl-tRNA synthetase (EcMetRS)-like proteins. This family includes EcMetRS and Aquifex aeolicus Trbp111 (AaTrbp111). This domain has general tRNA binding properties. MetRS aminoacylates methionine...; Region: tRNA_bind_EcMetRS_like; cd02800 358681000318 dimer interface [polypeptide binding]; other site 358681000319 putative tRNA-binding site [nucleotide binding]; other site 358681000320 Predicted metal-dependent hydrolases with the TIM-barrel fold [General function prediction only]; Region: COG1099 358681000321 TatD like proteins; E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310 358681000322 active site 358681000323 Domain of unknown function (DUF348); Region: DUF348; pfam03990 358681000324 Domain of unknown function (DUF348); Region: DUF348; pfam03990 358681000325 G5 domain; Region: G5; pfam07501 358681000326 3D domain; Region: 3D; cl01439 358681000327 ribonuclease M5; Region: 5S_RNA_mat_M5; TIGR00334 358681000328 TOPRIM_ RNase M5_like: The topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain found in Ribonuclease M5: (RNase M5) and other small primase-like proteins from bacteria and archaea. RNase M5 catalyzes the maturation of 5S rRNA in low...; Region: TOPRIM_RNase_M5_like; cd01027 358681000329 putative active site [active] 358681000330 putative metal binding site [ion binding]; other site 358681000331 Domain of unknown function (DUF4093); Region: DUF4093; pfam13331 358681000332 16S ribosomal RNA methyltransferase KsgA/Dim1 family protein; Reviewed; Region: ksgA; PRK00274 358681000333 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 358681000334 S-adenosylmethionine binding site [chemical binding]; other site 358681000335 Protein of unknown function (DUF1021); Region: DUF1021; pfam06257 358681000336 Small, acid-soluble spore proteins, alpha/beta type; Region: SASP; pfam00269 358681000337 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase; Provisional; Region: ipk; PRK00128 358681000338 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 358681000339 GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544 358681000340 pur operon repressor; Provisional; Region: PRK09213 358681000341 Bacterial purine repressor, N-terminal; Region: PuR_N; pfam09182 358681000342 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 358681000343 active site 358681000344 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 358681000345 homotrimer interaction site [polypeptide binding]; other site 358681000346 putative active site [active] 358681000347 regulatory protein SpoVG; Reviewed; Region: PRK13259 358681000348 Putative GTPases (G3E family) [General function prediction only]; Region: COG0523 358681000349 CobW/HypB/UreG, nucleotide-binding domain; Region: cobW; pfam02492 358681000350 Circularly permuted YlqF-related GTPases; Region: YlqF_related_GTPase; cl17249 358681000351 GTP/Mg2+ binding site [chemical binding]; other site 358681000352 G4 box; other site 358681000353 G5 box; other site 358681000354 G1 box; other site 358681000355 Switch I region; other site 358681000356 Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; pfam07683 358681000357 G2 box; other site 358681000358 G3 box; other site 358681000359 bifunctional N-acetylglucosamine-1-phosphate uridyltransferase/glucosamine-1-phosphate acetyltransferase; Provisional; Region: glmU; PRK14354 358681000360 N-terminal domain of bacterial GlmU; Region: GT2_GlmU_N_bac; cd02540 358681000361 Substrate binding site; other site 358681000362 Mg++ binding site; other site 358681000363 N-acetyl-glucosamine-1-phosphate uridyltransferase (GlmU), C-terminal left-handed beta-helix (LbH) acetyltransferase domain: GlmU is also known as UDP-N-acetylglucosamine pyrophosphorylase. It is a bifunctional bacterial enzyme that catalyzes two...; Region: LbH_GlmU_C; cd03353 358681000364 active site 358681000365 substrate binding site [chemical binding]; other site 358681000366 CoA binding site [chemical binding]; other site 358681000367 ribose-phosphate pyrophosphokinase; Provisional; Region: PRK01259 358681000368 N-terminal domain of ribose phosphate pyrophosphokinase; Region: Pribosyltran_N; pfam13793 358681000369 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 358681000370 active site 358681000371 50S ribosomal protein L25/general stress protein Ctc; Reviewed; Region: PRK05618 358681000372 Ribosomal L25/TL5/CTC N-terminal 5S rRNA binding domain; Region: Ribosomal_L25_TL5_CTC; cd00495 358681000373 5S rRNA interface [nucleotide binding]; other site 358681000374 CTC domain interface [polypeptide binding]; other site 358681000375 L16 interface [polypeptide binding]; other site 358681000376 Peptidyl-tRNA hydrolase (PTH) is a monomeric protein that cleaves the ester bond linking the nascent peptide and tRNA when peptidyl-tRNA is released prematurely from the ribosome. This ensures the recycling of peptidyl-tRNAs into tRNAs produced through...; Region: PTH; cd00462 358681000377 putative active site [active] 358681000378 catalytic residue [active] 358681000379 Protein of unknown function (DUF2757); Region: DUF2757; pfam10955 358681000380 Transcription-repair coupling factor (superfamily II helicase) [DNA replication, recombination, and repair / Transcription]; Region: Mfd; COG1197 358681000381 CarD-like/TRCF domain; Region: CarD_CdnL_TRCF; pfam02559 358681000382 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 358681000383 ATP binding site [chemical binding]; other site 358681000384 putative Mg++ binding site [ion binding]; other site 358681000385 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 358681000386 nucleotide binding region [chemical binding]; other site 358681000387 ATP-binding site [chemical binding]; other site 358681000388 TRCF domain; Region: TRCF; pfam03461 358681000389 peptidylprolyl isomerase; Provisional; Region: prsA; PRK00059 358681000390 PPIC-type PPIASE domain; Region: Rotamase_3; pfam13616 358681000391 stage V sporulation protein T; Region: spore_V_T; TIGR02851 358681000392 looped-hinge helix DNA binding domain, AbrB family; Region: lp_hng_hel_AbrB; TIGR01439 358681000393 GAF domain; Region: GAF; cl17456 358681000394 stage V sporulation protein B; Region: spore_V_B; TIGR02900 358681000395 Stage V sporulation protein B, also known as Stage III sporulation protein F, and related proteins; Region: MATE_SpoVB_like; cd13124 358681000396 Protein containing tetrapyrrole methyltransferase domain and MazG-like (predicted pyrophosphatase) domain [General function prediction only]; Region: COG3956 358681000397 N-terminal S-AdoMet dependent methylase domain of Bacillus subtilis YabN and related proteins; Region: YabN_N; cd11723 358681000398 putative SAM binding site [chemical binding]; other site 358681000399 putative homodimer interface [polypeptide binding]; other site 358681000400 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) N-terminal tandem-domain of MazG proteins from Escherichia coli and bacterial homologs; Region: NTP-PPase_MazG_Nterm; cd11528 358681000401 homodimer interface [polypeptide binding]; other site 358681000402 metal binding site [ion binding]; metal-binding site 358681000403 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) C-terminal tandem-domain of MazG proteins from Escherichia coli and bacterial homologs' Region: NTP-PPase_MazG_Cterm; cd11529 358681000404 homodimer interface [polypeptide binding]; other site 358681000405 active site 358681000406 putative chemical substrate binding site [chemical binding]; other site 358681000407 metal binding site [ion binding]; metal-binding site 358681000408 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 358681000409 RNA binding surface [nucleotide binding]; other site 358681000410 Predicted membrane protein (DUF2157); Region: DUF2157; pfam09925 358681000411 GDYXXLXY protein; Region: GDYXXLXY; pfam14345 358681000412 Major Facilitator Superfamily; Region: MFS_1; pfam07690 358681000413 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 358681000414 putative substrate translocation pore; other site 358681000415 ABC-type uncharacterized transport system, periplasmic component [General function prediction only]; Region: COG4533 358681000416 Sugar transport-related sRNA regulator N-term; Region: SgrR_N; pfam12793 358681000417 The C-terminal solute-binding domain of DNA-binding transcriptional regulator SgrR is related to the ABC-type oligopeptide-binding proteins and contains the type 2 periplasmic-binding fold; Region: PBP2_SgrR_like; cd08507 358681000418 Copper amine oxidase N-terminal domain; Region: Cu_amine_oxidN1; pfam07833 358681000419 sporulation protein YabP; Region: spore_yabP; TIGR02892 358681000420 Spore cortex protein YabQ (Spore_YabQ); Region: Spore_YabQ; cl09801 358681000421 Septum formation initiator [Cell division and chromosome partitioning]; Region: COG2919 358681000422 Septum formation initiator; Region: DivIC; pfam04977 358681000423 stage II sporulation protein E; Region: spore_II_E; TIGR02865 358681000424 Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228 358681000425 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057 358681000426 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198 358681000427 metal ion-dependent adhesion site (MIDAS); other site 358681000428 Serine/threonine protein kinase [General function prediction only / Signal transduction mechanisms / Transcription / DNA replication, recombination, and repair]; Region: SPS1; COG0515 358681000429 Catalytic domain of Protein Kinases; Region: PKc; cd00180 358681000430 active site 358681000431 ATP binding site [chemical binding]; other site 358681000432 substrate binding site [chemical binding]; other site 358681000433 activation loop (A-loop); other site 358681000434 Uncharacterized conserved protein [Function unknown]; Region: COG2966 358681000435 Protein of unknown function (DUF1212); Region: DUF1212; pfam06738 358681000436 Protein of unknown function (DUF3815); Region: DUF3815; cl01118 358681000437 Protein of unknown function (DUF3815); Region: DUF3815; pfam12821 358681000438 tRNA(Ile)-lysidine synthase MesJ [Cell cycle control, cell division, chromosome partitioning]; Region: MesJ; COG0037 358681000439 N-terminal domain of predicted ATPase of the PP-loop faimly implicated in cell cycle control [Cell division and chromosome partitioning]. This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases...; Region: PP-ATPase; cd01992 358681000440 Ligand Binding Site [chemical binding]; other site 358681000441 TilS substrate C-terminal domain; Region: TilS_C; smart00977 358681000442 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 358681000443 active site 358681000444 FtsH Extracellular; Region: FtsH_ext; pfam06480 358681000445 ATP-dependent metalloprotease FtsH; Region: FtsH_fam; TIGR01241 358681000446 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 358681000447 Walker A motif; other site 358681000448 ATP binding site [chemical binding]; other site 358681000449 Walker B motif; other site 358681000450 arginine finger; other site 358681000451 Peptidase family M41; Region: Peptidase_M41; pfam01434 358681000452 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 358681000453 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 358681000454 active site 358681000455 motif I; other site 358681000456 motif II; other site 358681000457 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 358681000458 Quinolinate synthetase A protein; Region: NadA; pfam02445 358681000459 Protein of unknown function with PCYCGC motif; Region: PCYCGC; pfam13798 358681000460 ABC-type metal ion transport system, periplasmic component/surface adhesin [Inorganic ion transport and metabolism]; Region: LraI; COG0803 358681000461 Metal binding protein AcdA. These proteins have been shown to function in the ABC uptake of Zn2+ and Mn2+ and in competence for genetic transformation and adhesion. The AcdA proteins belong to the TroA superfamily of helical backbone metal receptor...; Region: AdcA; cd01017 358681000462 metal binding site [ion binding]; metal-binding site 358681000463 ABC-type Mn/Zn transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: ZnuC; COG1121 358681000464 ATP-binding cassette domain of the metal-type transporters; Region: ABC_Metallic_Cations; cd03235 358681000465 ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108 358681000466 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 358681000467 ABC-ATPase subunit interface; other site 358681000468 dimer interface [polypeptide binding]; other site 358681000469 putative PBP binding regions; other site 358681000470 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 358681000471 metal binding site 2 [ion binding]; metal-binding site 358681000472 putative DNA binding helix; other site 358681000473 metal binding site 1 [ion binding]; metal-binding site 358681000474 dimer interface [polypeptide binding]; other site 358681000475 structural Zn2+ binding site [ion binding]; other site 358681000476 L-aspartate oxidase; Provisional; Region: PRK06175 358681000477 Aspartate oxidase [Coenzyme metabolism]; Region: NadB; COG0029 358681000478 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 358681000479 Nicotinate-nucleotide pyrophosphorylase [Coenzyme metabolism]; Region: NadC; COG0157 358681000480 Quinolinate phosphoribosyl transferase (QAPRTase or QPRTase), also called nicotinate-nucleotide pyrophosphorylase, is involved in the de novo synthesis of NAD in both prokaryotes and eukaryotes. It catalyses the reaction of quinolinic acid (QA) with...; Region: QPRTase; cd01572 358681000481 dimerization interface [polypeptide binding]; other site 358681000482 active site 358681000483 pantothenate kinase; Reviewed; Region: PRK13318 358681000484 Acetyltransferase (GNAT) domain; Region: Acetyltransf_8; pfam13523 358681000485 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 358681000486 Coenzyme A binding pocket [chemical binding]; other site 358681000487 Domains similar to fish antifreeze type III protein; Region: SAF; cl00555 358681000488 Response regulator receiver domain; Region: Response_reg; pfam00072 358681000489 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 358681000490 intermolecular recognition site; other site 358681000491 This protein family consists of proteins similar to the cpaE protein of the Caulobacter pilus assembly and the orf4 protein of Actinobacillus pilus formation gene cluster. The function of these proteins are unkown. The Caulobacter pilus assembly contains...; Region: CpaE_like; cd03111 358681000492 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 358681000493 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 358681000494 Flp pilus assembly protein, ATPase CpaF [Intracellular trafficking and secretion]; Region: CpaF; COG4962 358681000495 Type IV secretory pathway component VirB11, and related ATPases. The homohexamer, VirB11 is one of eleven Vir proteins, which are required for T-pilus biogenesis and virulence in the transfer of T-DNA from the Ti (tumor-inducing) plasmid of bacterial to...; Region: VirB11-like_ATPase; cd01130 358681000496 ATP binding site [chemical binding]; other site 358681000497 Walker A motif; other site 358681000498 hexamer interface [polypeptide binding]; other site 358681000499 Walker B motif; other site 358681000500 Flp pilus assembly protein TadB [Intracellular trafficking and secretion]; Region: TadB; COG4965 358681000501 Flp pilus assembly protein TadC [Cell motility and secretion / Intracellular trafficking and secretion]; Region: TadC; COG2064 358681000502 Type IV leader peptidase family; Region: Peptidase_A24; pfam01478 358681000503 Flp pilus assembly protein TadG [Intracellular trafficking and secretion]; Region: TadG; COG4961 358681000504 TadE-like protein; Region: TadE; pfam07811 358681000505 AAA domain; Region: AAA_31; pfam13614 358681000506 SAF domains of the flagella basal body P-ring formation protein FlgA and the flp pilus assembly CpaB; Region: SAF_CpaB_FlgA_like; cd11614 358681000507 AAA domain; Region: AAA_31; pfam13614 358681000508 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 358681000509 Walker A motif; other site 358681000510 ATP binding site [chemical binding]; other site 358681000511 Walker B motif; other site 358681000512 Domain of unknown function (DUF3870); Region: DUF3870; pfam12986 358681000513 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 358681000514 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 358681000515 dimer interface [polypeptide binding]; other site 358681000516 conserved gate region; other site 358681000517 putative PBP binding loops; other site 358681000518 ABC-ATPase subunit interface; other site 358681000519 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 358681000520 N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911 358681000521 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 358681000522 dimer interface [polypeptide binding]; other site 358681000523 conserved gate region; other site 358681000524 putative PBP binding loops; other site 358681000525 ABC-ATPase subunit interface; other site 358681000526 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 358681000527 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 358681000528 Walker A/P-loop; other site 358681000529 ATP binding site [chemical binding]; other site 358681000530 Q-loop/lid; other site 358681000531 ABC transporter signature motif; other site 358681000532 Walker B; other site 358681000533 D-loop; other site 358681000534 H-loop/switch region; other site 358681000535 oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727 358681000536 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 358681000537 The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504 358681000538 peptide binding site [polypeptide binding]; other site 358681000539 L-alanine-DL-glutamate epimerase and related enzymes of enolase superfamily [Cell envelope biogenesis, outer membrane / General function prediction only]; Region: COG4948 358681000540 L-Ala-D/L-Glu epimerase catalyzes the epimerization of L-Ala-D/L-Glu and other dipeptides. The genomic context and the substrate specificity of characterized members of this family from E.coli and B.subtilis indicates a possible role in the metabolism of...; Region: L-Ala-DL-Glu_epimerase; cd03319 358681000541 active site 358681000542 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 358681000543 NlpC/P60 family; Region: NLPC_P60; pfam00877 358681000544 oligopeptide ABC transporter ATP-binding protein OppF; Provisional; Region: PRK15079 358681000545 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 358681000546 Walker A/P-loop; other site 358681000547 ATP binding site [chemical binding]; other site 358681000548 Q-loop/lid; other site 358681000549 ABC transporter signature motif; other site 358681000550 Walker B; other site 358681000551 D-loop; other site 358681000552 H-loop/switch region; other site 358681000553 oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727 358681000554 RNA polymerase sigma factor RpoD, C-terminal domain; Region: RpoD_Cterm; TIGR02393 358681000555 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 358681000556 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 358681000557 DNA binding residues [nucleotide binding] 358681000558 Hsp33-like chaperonin; Reviewed; Region: hslO; PRK00114 358681000559 Heat shock protein 33 (Hsp33): Cytosolic protein that acts as a molecular chaperone under oxidative conditions. In normal (reducing) cytosolic conditions, four conserved Cys residues are coordinated by a Zn ion. Under oxidative stress (such as heat...; Region: Hsp33; cd00498 358681000560 dimerization interface [polypeptide binding]; other site 358681000561 domain crossover interface; other site 358681000562 redox-dependent activation switch; other site 358681000563 SurA N-terminal domain; Region: SurA_N_3; cl07813 358681000564 PPIC-type PPIASE domain; Region: Rotamase_2; pfam13145 358681000565 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 358681000566 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 358681000567 dimer interface [polypeptide binding]; other site 358681000568 pyridoxal 5'-phosphate binding site [chemical binding]; other site 358681000569 catalytic residue [active] 358681000570 Anthranilate/para-aminobenzoate synthases component I [Amino acid transport and metabolism / Coenzyme metabolism]; Region: TrpE; COG0147 358681000571 Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715 358681000572 chorismate binding enzyme; Region: Chorismate_bind; pfam00425 358681000573 para-aminobenzoate synthase component II; Provisional; Region: PRK08857 358681000574 Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743 358681000575 glutamine binding [chemical binding]; other site 358681000576 catalytic triad [active] 358681000577 Alkaline phosphatase homologues; Region: alkPPc; smart00098 358681000578 Alkaline phosphatase homologues; alkaline phosphatases are non-specific phosphomonoesterases that catalyze the hydrolysis reaction via a phosphoseryl intermediate to produce inorganic phosphate and the corresponding alcohol, optimally at high pH; Region: alkPPc; cd00016 358681000579 active site 358681000580 dimer interface [polypeptide binding]; other site 358681000581 twin arginine translocase protein A; Provisional; Region: tatA; PRK14861 358681000582 Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115 358681000583 PyridoxaL 5'-Phosphate Dependent Enzymes class IV (PLPDE_IV). This D-amino acid superfamily, one of five classes of PLPDE, consists of branched-chain amino acid aminotransferases (BCAT), D-amino acid transferases (DAAT), and...; Region: PLPDE_IV; cl00224 358681000584 homodimer interface [polypeptide binding]; other site 358681000585 substrate-cofactor binding pocket; other site 358681000586 pyridoxal 5'-phosphate binding site [chemical binding]; other site 358681000587 catalytic residue [active] 358681000588 DHPS subgroup of Pterin binding enzymes. DHPS (dihydropteroate synthase), a functional homodimer, catalyzes the condensation of p-aminobenzoic acid (pABA) in the de novo biosynthesis of folate, which is an essential cofactor in both nucleic acid and...; Region: DHPS; cd00739 358681000589 dihydropteroate synthase; Region: DHPS; TIGR01496 358681000590 substrate binding pocket [chemical binding]; other site 358681000591 dimer interface [polypeptide binding]; other site 358681000592 inhibitor binding site; inhibition site 358681000593 Dihydroneopterin aldolase (DHNA) and 7,8-dihydroneopterin triphosphate epimerase domain (DHNTPE); these enzymes have been designated folB and folX, respectively. Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and...; Region: DHNA_DHNTPE; cd00534 358681000594 homooctamer interface [polypeptide binding]; other site 358681000595 active site 358681000596 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase (HPPK). Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and amino acids as well as formyl-tRNA. Mammalian cells are able to utilize pre-formed folates after...; Region: HPPK; cd00483 358681000597 catalytic center binding site [active] 358681000598 ATP binding site [chemical binding]; other site 358681000599 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 358681000600 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 358681000601 non-specific DNA binding site [nucleotide binding]; other site 358681000602 salt bridge; other site 358681000603 sequence-specific DNA binding site [nucleotide binding]; other site 358681000604 putative TIM-barrel protein, nifR3 family; Region: nifR3_yhdG; TIGR00737 358681000605 Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801 358681000606 FMN binding site [chemical binding]; other site 358681000607 active site 358681000608 catalytic residues [active] 358681000609 substrate binding site [chemical binding]; other site 358681000610 transcription elongation factor GreA; Reviewed; Region: greA; PRK00226 358681000611 Transcription elongation factor, N-terminal; Region: GreA_GreB_N; pfam03449 358681000612 Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272 358681000613 lysyl-tRNA synthetase; Reviewed; Region: lysS; PRK00484 358681000614 LysRS_N: N-terminal, anticodon recognition domain of lysyl-tRNA synthetases (LysRS). These enzymes are homodimeric class 2b aminoacyl-tRNA synthetases (aaRSs). This domain is a beta-barrel domain (OB fold) involved in binding the tRNA anticodon stem-loop; Region: LysRS_N; cd04322 358681000615 dimer interface [polypeptide binding]; other site 358681000616 putative anticodon binding site; other site 358681000617 Lys_tRNA synthetase (LysRS) class II core domain. Class II LysRS is a dimer which attaches a lysine to the 3' OH group of ribose of the appropriate tRNA. Its assignment to class II aaRS is based upon its structure and the presence of three...; Region: LysRS_core; cd00775 358681000618 motif 1; other site 358681000619 active site 358681000620 motif 2; other site 358681000621 motif 3; other site 358681000622 diacylglycerol glucosyltransferase; Provisional; Region: PRK13609 358681000623 Monogalactosyldiacylglycerol (MGDG) synthase; Region: MGDG_synth; pfam06925 358681000624 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 358681000625 Predicted phosphatases [General function prediction only]; Region: Gph; COG0546 358681000626 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 358681000627 motif II; other site 358681000628 Firmicute transcriptional repressor of class III stress genes (CtsR); Region: CtsR; pfam05848 358681000629 Modulator of heat shock repressor CtsR, McsA [Signal transduction mechanisms]; Region: COG3880 358681000630 UvrB/uvrC motif; Region: UVR; pfam02151 358681000631 ATP:guanido phosphotransferase; Provisional; Region: PRK01059 358681000632 Phosphagen (guanidino) kinases found in bacteria; Region: bacterial_phosphagen_kinase; cd07930 358681000633 ADP binding site [chemical binding]; other site 358681000634 phosphagen binding site; other site 358681000635 substrate specificity loop; other site 358681000636 ATP-binding subunits of Clp protease and DnaK/DnaJ chaperones [Posttranslational modification, protein turnover, chaperones]; Region: clpA; COG0542 358681000637 Clp amino terminal domain; Region: Clp_N; pfam02861 358681000638 Clp amino terminal domain; Region: Clp_N; pfam02861 358681000639 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 358681000640 Walker A motif; other site 358681000641 ATP binding site [chemical binding]; other site 358681000642 Walker B motif; other site 358681000643 arginine finger; other site 358681000644 UvrB/uvrC motif; Region: UVR; pfam02151 358681000645 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 358681000646 Walker A motif; other site 358681000647 ATP binding site [chemical binding]; other site 358681000648 Walker B motif; other site 358681000649 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 358681000650 DNA repair protein RadA; Provisional; Region: PRK11823 358681000651 Sms (bacterial radA) DNA repair protein. This protein is not related to archael radA any more than is to other RecA-like NTPases. Sms has a role in recombination and recombinational repair and is responsible for the stabilization or processing of...; Region: Sms; cd01121 358681000652 Walker A motif/ATP binding site; other site 358681000653 ATP binding site [chemical binding]; other site 358681000654 Walker B motif; other site 358681000655 Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541 358681000656 DNA integrity scanning protein DisA; Provisional; Region: PRK13482 358681000657 DisA bacterial checkpoint controller nucleotide-binding; Region: DisA_N; pfam02457 358681000658 DisA bacterial checkpoint controller linker region; Region: DisA-linker; pfam10635 358681000659 Phosphatidylserine synthase [Lipid metabolism]; Region: PssA; COG1183 358681000660 CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; pfam01066 358681000661 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain superfamily; Region: NTP-PPase; cl16941 358681000662 Integral membrane protein (PIN domain superfamily) [General function prediction only]; Region: COG4956 358681000663 Etoposide-induced protein 2.4 (EI24); Region: EI24; pfam07264 358681000664 PIN domain of Thermus Thermophilus Hb8, uncharacterized Bacillus subtilis YacL, and other bacterial homologs; Region: PIN_YacL; cd09877 358681000665 putative active site [active] 358681000666 CDP-ME synthetase is involved in mevalonate-independent isoprenoid production; Region: CDP-ME_synthetase; cd02516 358681000667 substrate binding site; other site 358681000668 dimer interface; other site 358681000669 MECDP_synthase (2-C-methyl-D-erythritol-2,4-cyclodiphosphate synthase), encoded by the ispF gene, catalyzes the formation of 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (MEC) in the non-mevalonate deoxyxylulose (DOXP) pathway for isoprenoid biosynthesis; Region: MECDP_synthase; cd00554 358681000670 homotrimer interaction site [polypeptide binding]; other site 358681000671 zinc binding site [ion binding]; other site 358681000672 CDP-binding sites; other site 358681000673 glutamyl-tRNA synthetase; Reviewed; Region: gltX; PRK01406 358681000674 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 358681000675 active site 358681000676 HIGH motif; other site 358681000677 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 358681000678 active site 358681000679 KMSKS motif; other site 358681000680 Serine acetyltransferase [Amino acid transport and metabolism]; Region: CysE; COG1045 358681000681 Serine acetyltransferase, N-terminal; Region: SATase_N; cl05762 358681000682 Serine acetyltransferase (SAT): SAT catalyzes the CoA-dependent acetylation of the side chain hydroxyl group of L-serine to form O-acetylserine, as the first step of a two-step biosynthetic pathway in bacteria and plants leading to the formation of...; Region: LbH_SAT; cd03354 358681000683 trimer interface [polypeptide binding]; other site 358681000684 active site 358681000685 substrate binding site [chemical binding]; other site 358681000686 CoA binding site [chemical binding]; other site 358681000687 cysteinyl-tRNA synthetase; Validated; Region: cysS; PRK00260 358681000688 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 358681000689 active site 358681000690 HIGH motif; other site 358681000691 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 358681000692 KMSKS motif; other site 358681000693 Anticodon-binding domain of cysteinyl tRNA synthetases; Region: Anticodon_Ia_Cys; cd07963 358681000694 tRNA binding surface [nucleotide binding]; other site 358681000695 anticodon binding site; other site 358681000696 RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in...; Region: RIBOc; cd00593 358681000697 dimerization interface [polypeptide binding]; other site 358681000698 active site 358681000699 metal binding site [ion binding]; metal-binding site 358681000700 rRNA methylase, putative, group 3; Region: rRNA_methyl_3; TIGR00186 358681000701 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; pfam08032 358681000702 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 358681000703 YacP-like NYN domain; Region: NYN_YacP; pfam05991 358681000704 RNA polymerase factor sigma-70; Validated; Region: PRK08295 358681000705 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 358681000706 Sigma-70, region 4; Region: Sigma70_r4_2; pfam08281 358681000707 50S ribosomal protein L33; Validated; Region: rpmG; PRK00595 358681000708 preprotein translocase subunit SecE; Reviewed; Region: secE; PRK07597 358681000709 transcription antitermination protein NusG; Validated; Region: nusG; PRK05609 358681000710 Bacterial N-Utilization Substance G (NusG) N-terminal (NGN) domain, subgroup 1; Region: NGN_Bact_1; cd09891 358681000711 putative homodimer interface [polypeptide binding]; other site 358681000712 NusG contains an NGN domain at its N-terminus and KOW motif at its C-terminus; Region: KOW_NusG; cd06091 358681000713 heterodimer interface [polypeptide binding]; other site 358681000714 homodimer interface [polypeptide binding]; other site 358681000715 50S ribosomal protein L11; Validated; Region: rplK; PRK00140 358681000716 Ribosomal protein L11. Ribosomal protein L11, together with proteins L10 and L7/L12, and 23S rRNA, form the L7/L12 stalk on the surface of the large subunit of the ribosome. The homologous eukaryotic cytoplasmic protein is also called 60S ribosomal...; Region: Ribosomal_L11; cd00349 358681000717 23S rRNA interface [nucleotide binding]; other site 358681000718 L7/L12 interface [polypeptide binding]; other site 358681000719 putative thiostrepton binding site; other site 358681000720 L25 interface [polypeptide binding]; other site 358681000721 Ribosomal protein L1. The L1 protein, located near the E-site of the ribosome, forms part of the L1 stalk along with 23S rRNA. In bacteria and archaea, L1 functions both as a ribosomal protein that binds rRNA, and as a translation repressor that binds...; Region: Ribosomal_L1; cd00403 358681000722 mRNA/rRNA interface [nucleotide binding]; other site 358681000723 Ribosomal protein L10 family, L10 subfamily; composed of bacterial 50S ribosomal protein and eukaryotic mitochondrial 39S ribosomal protein, L10. L10 occupies the L7/L12 stalk of the ribosome. The N-terminal domain (NTD) of L10 interacts with L11 protein...; Region: Ribosomal_L10; cd05797 358681000724 23S rRNA interface [nucleotide binding]; other site 358681000725 Interface with L7/L12 ribosomal proteins [polypeptide binding]; other site 358681000726 Ribosomal protein L7/L12. Ribosomal protein L7/L12 refers to the large ribosomal subunit proteins L7 and L12, which are identical except that L7 is acetylated at the N terminus. It is a component of the L7/L12 stalk, which is located at the surface of...; Region: Ribosomal_L7_L12; cd00387 358681000727 core dimer interface [polypeptide binding]; other site 358681000728 peripheral dimer interface [polypeptide binding]; other site 358681000729 L10 interface [polypeptide binding]; other site 358681000730 L11 interface [polypeptide binding]; other site 358681000731 putative EF-Tu interaction site [polypeptide binding]; other site 358681000732 putative EF-G interaction site [polypeptide binding]; other site 358681000733 Methyltransferase domain; Region: Methyltransf_31; pfam13847 358681000734 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 358681000735 S-adenosylmethionine binding site [chemical binding]; other site 358681000736 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cl17585 358681000737 RNA polymerase Rpb2, domain 2; Region: RNA_pol_Rpb2_2; pfam04561 358681000738 DNA-directed RNA polymerase subunit beta; Reviewed; Region: rpoB; PRK00405 358681000739 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653 358681000740 RPB12 interaction site [polypeptide binding]; other site 358681000741 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653 358681000742 RPB10 interaction site [polypeptide binding]; other site 358681000743 RPB1 interaction site [polypeptide binding]; other site 358681000744 RPB11 interaction site [polypeptide binding]; other site 358681000745 RPB3 interaction site [polypeptide binding]; other site 358681000746 RPB12 interaction site [polypeptide binding]; other site 358681000747 DNA-directed RNA polymerase subunit beta'; Provisional; Region: PRK00566 358681000748 RNA polymerase Rpb1, domain 1; Region: RNA_pol_Rpb1_1; pfam04997 358681000749 RNA polymerase I subunit A N-terminus; Region: RPOLA_N; smart00663 358681000750 RNA polymerase Rpb1, domain 3; Region: RNA_pol_Rpb1_3; pfam04983 358681000751 RNA polymerase Rpb1, domain 4; Region: RNA_pol_Rpb1_4; pfam05000 358681000752 Largest subunit (beta') of Bacterial DNA-dependent RNA polymerase (RNAP), C-terminal domain; Region: RNAP_beta'_C; cd02655 358681000753 Rpb1 (beta') - Rpb6 (omega) interaction site [polypeptide binding]; other site 358681000754 Rpb1 (beta') - Rpb2 (beta) interaction site [polypeptide binding]; other site 358681000755 G-loop; other site 358681000756 DNA binding site [nucleotide binding] 358681000757 putative ribosomal protein L7Ae-like; Provisional; Region: PRK13602 358681000758 S12-like family, 30S ribosomal protein S12 subfamily; S12 is located at the interface of the large and small ribosomal subunits of prokaryotes, chloroplasts and mitochondria, where it plays an important role in both tRNA and ribosomal subunit...; Region: Ribosomal_S12; cd03368 358681000759 S17 interaction site [polypeptide binding]; other site 358681000760 S8 interaction site; other site 358681000761 16S rRNA interaction site [nucleotide binding]; other site 358681000762 streptomycin interaction site [chemical binding]; other site 358681000763 23S rRNA interaction site [nucleotide binding]; other site 358681000764 aminoacyl-tRNA interaction site (A-site) [nucleotide binding]; other site 358681000765 30S ribosomal protein S7; Validated; Region: PRK05302 358681000766 elongation factor G; Reviewed; Region: PRK00007 358681000767 Elongation factor G (EF-G) family involved in both the elongation and ribosome recycling phases of protein synthesis; Region: EF-G; cd01886 358681000768 G1 box; other site 358681000769 putative GEF interaction site [polypeptide binding]; other site 358681000770 GTP/Mg2+ binding site [chemical binding]; other site 358681000771 Switch I region; other site 358681000772 G2 box; other site 358681000773 G3 box; other site 358681000774 Switch II region; other site 358681000775 G4 box; other site 358681000776 G5 box; other site 358681000777 EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088 358681000778 EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434 358681000779 EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G. Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713 358681000780 elongation factor Tu; Reviewed; Region: PRK00049 358681000781 Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884 358681000782 G1 box; other site 358681000783 GEF interaction site [polypeptide binding]; other site 358681000784 GTP/Mg2+ binding site [chemical binding]; other site 358681000785 Switch I region; other site 358681000786 G2 box; other site 358681000787 G3 box; other site 358681000788 Switch II region; other site 358681000789 G4 box; other site 358681000790 G5 box; other site 358681000791 EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697 358681000792 Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707 358681000793 Antibiotic Binding Site [chemical binding]; other site 358681000794 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 358681000795 EamA-like transporter family; Region: EamA; pfam00892 358681000796 EamA-like transporter family; Region: EamA; pfam00892 358681000797 Truncated hemoglobins (trHbs) are a family of oxygen-binding heme proteins found in cyanobacteria, eubacteria, unicellular eukaryotes, and plants. The truncated hemoglobins have a characteristic two-over-two alpha helical folding pattern that is distinct...; Region: Trunc_globin; cd00454 358681000798 apolar tunnel; other site 358681000799 heme binding site [chemical binding]; other site 358681000800 dimerization interface [polypeptide binding]; other site 358681000801 30S ribosomal protein S10; Reviewed; Region: rpsJ; PRK00596 358681000802 50S ribosomal protein L3; Validated; Region: rplC; PRK00001 358681000803 50S ribosomal protein L4; Provisional; Region: rplD; PRK05319 358681000804 50S ribosomal protein L23; Reviewed; Region: rplW; PRK05738 358681000805 50S ribosomal protein L2; Validated; Region: rplB; PRK09374 358681000806 Ribosomal Proteins L2, RNA binding domain; Region: Ribosomal_L2; pfam00181 358681000807 Ribosomal Proteins L2, C-terminal domain; Region: Ribosomal_L2_C; pfam03947 358681000808 30S ribosomal protein S19; Reviewed; Region: rpsS; PRK00357 358681000809 Ribosomal protein L22/L17e. L22 (L17 in eukaryotes) is a core protein of the large ribosomal subunit. It is the only ribosomal protein that interacts with all six domains of 23S rRNA, and is one of the proteins important for directing the proper...; Region: Ribosomal_L22; cd00336 358681000810 putative translocon binding site; other site 358681000811 protein-rRNA interface [nucleotide binding]; other site 358681000812 30S ribosomal protein S3; Reviewed; Region: rpsC; PRK00310 358681000813 K homology RNA-binding (KH) domain of the prokaryotic 30S small ribosomal subunit protein S3. S3 is part of the head region of the 30S ribosomal subunit and is believed to interact with mRNA as it threads its way from the latch into the channel. The KH...; Region: 30S_S3_KH; cd02412 358681000814 G-X-X-G motif; other site 358681000815 Ribosomal protein S3, C-terminal domain; Region: Ribosomal_S3_C; pfam00189 358681000816 Ribosomal_L16_L10e: L16 is an essential protein in the large ribosomal subunit of bacteria, mitochondria, and chloroplasts. Large subunits that lack L16 are defective in peptidyl transferase activity, peptidyl-tRNA hydrolysis activity, association with...; Region: Ribosomal_L16_L10e; cd01433 358681000817 23S rRNA interface [nucleotide binding]; other site 358681000818 5S rRNA interface [nucleotide binding]; other site 358681000819 putative antibiotic binding site [chemical binding]; other site 358681000820 L25 interface [polypeptide binding]; other site 358681000821 L27 interface [polypeptide binding]; other site 358681000822 Ribosomal L29 protein/HIP. L29 is a protein of the large ribosomal Subunit. A homolog, called heparin/heparan sulfate interacting protein (HIP), has also been identified in mammals. L29 is located on the surface of the large ribosomal subunit, where it...; Region: Ribosomal_L29_HIP; cd00427 358681000823 23S rRNA interface [nucleotide binding]; other site 358681000824 putative translocon interaction site; other site 358681000825 signal recognition particle (SRP54) interaction site; other site 358681000826 L23 interface [polypeptide binding]; other site 358681000827 trigger factor interaction site; other site 358681000828 30S ribosomal protein S17; Reviewed; Region: rpsQ; PRK05610 358681000829 50S ribosomal protein L14; Validated; Region: rplN; PRK05483 358681000830 50S ribosomal protein L24; Reviewed; Region: rplX; PRK00004 358681000831 KOW motif of Ribosomal Protein L26; Region: KOW_RPL26; cd06089 358681000832 RNA binding site [nucleotide binding]; other site 358681000833 50S ribosomal protein L5; Validated; Region: rplE; PRK00010 358681000834 Ribosomal protein L5; Region: Ribosomal_L5; pfam00281 358681000835 ribosomal L5P family C-terminus; Region: Ribosomal_L5_C; pfam00673 358681000836 30S ribosomal protein S14; Reviewed; Region: rpsN; PRK08061 358681000837 30S ribosomal protein S8; Validated; Region: rpsH; PRK00136 358681000838 50S ribosomal protein L6; Validated; Region: rplF; PRK05498 358681000839 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 358681000840 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 358681000841 Ribosomal L18/L5e: L18 (L5e) is a ribosomal protein found in the central protuberance (CP) of the large subunit. L18 binds 5S rRNA and induces a conformational change that stimulates the binding of L5 to 5S rRNA. Association of 5S rRNA with 23S rRNA...; Region: Ribosomal_L18_L5e; cd00432 358681000842 23S rRNA interface [nucleotide binding]; other site 358681000843 L21e interface [polypeptide binding]; other site 358681000844 5S rRNA interface [nucleotide binding]; other site 358681000845 L27 interface [polypeptide binding]; other site 358681000846 L5 interface [polypeptide binding]; other site 358681000847 30S ribosomal protein S5; Validated; Region: rpsE; PRK00550 358681000848 Ribosomal protein S5, N-terminal domain; Region: Ribosomal_S5; pfam00333 358681000849 Ribosomal protein S5, C-terminal domain; Region: Ribosomal_S5_C; pfam03719 358681000850 Ribosomal protein L30, which is found in eukaryotes and prokaryotes but not in archaea, is one of the smallest ribosomal proteins with a molecular mass of about 7kDa. L30 binds the 23SrRNA as well as the 5S rRNA and is one of five ribosomal proteins that...; Region: Ribosomal_L30; cd01658 358681000851 23S rRNA binding site [nucleotide binding]; other site 358681000852 50S ribosomal protein L15; Reviewed; Region: rplO; PRK05592 358681000853 preprotein translocase subunit SecY; Reviewed; Region: secY; PRK09204 358681000854 SecY translocase; Region: SecY; pfam00344 358681000855 adenylate kinase; Reviewed; Region: adk; PRK00279 358681000856 Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for...; Region: ADK; cd01428 358681000857 AMP-binding site [chemical binding]; other site 358681000858 ATP-AMP (Ap5A)-binding site [chemical binding]; other site 358681000859 Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086 358681000860 active site 358681000861 S1_IF1: Translation Initiation Factor IF1, S1-like RNA-binding domain. IF1 contains an S1-like RNA-binding domain, which is found in a wide variety of RNA-associated proteins. Translation initiation includes a number of interrelated steps preceding the...; Region: S1_IF1; cd04451 358681000862 rRNA binding site [nucleotide binding]; other site 358681000863 predicted 30S ribosome binding site; other site 358681000864 50S ribosomal protein L36; Reviewed; Region: rpmJ; PRK00465 358681000865 30S ribosomal protein S13; Validated; Region: rpsM; PRK05179 358681000866 30S ribosomal protein S13; Region: bact_S13; TIGR03631 358681000867 30S ribosomal protein S11; Validated; Region: PRK05309 358681000868 DNA-directed RNA polymerase subunit alpha; Provisional; Region: PRK05182 358681000869 N-terminal domain of the Alpha subunit of Bacterial RNA polymerase; Region: RNAP_alpha_NTD; cd06928 358681000870 alphaNTD - beta interaction site [polypeptide binding]; other site 358681000871 alphaNTD homodimer interface [polypeptide binding]; other site 358681000872 alphaNTD - beta' interaction site [polypeptide binding]; other site 358681000873 Bacterial RNA polymerase, alpha chain C terminal domain; Region: RNA_pol_A_CTD; pfam03118 358681000874 50S ribosomal protein L17; Validated; Region: rplQ; PRK05591 358681000875 cobalt transporter ATP-binding subunit; Provisional; Region: PRK13633 358681000876 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 358681000877 Walker A/P-loop; other site 358681000878 ATP binding site [chemical binding]; other site 358681000879 Q-loop/lid; other site 358681000880 ABC transporter signature motif; other site 358681000881 Walker B; other site 358681000882 D-loop; other site 358681000883 H-loop/switch region; other site 358681000884 cobalt transporter ATP-binding subunit; Provisional; Region: cbiO; PRK13634 358681000885 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 358681000886 Walker A/P-loop; other site 358681000887 ATP binding site [chemical binding]; other site 358681000888 Q-loop/lid; other site 358681000889 ABC transporter signature motif; other site 358681000890 Walker B; other site 358681000891 D-loop; other site 358681000892 H-loop/switch region; other site 358681000893 ABC-type cobalt transport system, permease component CbiQ and related transporters [Inorganic ion transport and metabolism]; Region: CbiQ; COG0619 358681000894 tRNA pseudouridine synthase A; Validated; Region: truA; PRK00021 358681000895 Eukaryotic and bacterial pseudouridine synthases similar to E. coli TruA; Region: PseudoU_synth_EcTruA; cd02570 358681000896 dimerization interface 3.5A [polypeptide binding]; other site 358681000897 active site 358681000898 Ribosomal protein L13. Protein L13, a large ribosomal subunit protein, is one of five proteins required for an early folding intermediate of 23S rRNA in the assembly of the large subunit. L13 is situated on the bottom of the large subunit, near the...; Region: Ribosomal_L13; cd00392 358681000899 23S rRNA interface [nucleotide binding]; other site 358681000900 L3 interface [polypeptide binding]; other site 358681000901 30S ribosomal protein S9; Reviewed; Region: rpsI; PRK00132 358681000902 N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860 358681000903 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 358681000904 active site 358681000905 metal binding site [ion binding]; metal-binding site 358681000906 Domain of unknown function DUF59; Region: DUF59; pfam01883 358681000907 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 358681000908 KinB-signalling pathway activation in sporulation; Region: KbaA; pfam14089 358681000909 Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726 358681000910 Catalytic NodB homology domain of the carbohydrate esterase 4 superfamily; Region: CE4_SF; cl15692 358681000911 Integral membrane protein DUF95; Region: DUF95; pfam01944 358681000912 succinate dehydrogenase flavoprotein subunit; Reviewed; Region: sdhA; PRK07573 358681000913 Arginase family; Region: Arginase; cd09989 358681000914 agmatinase; Region: agmatinase; TIGR01230 358681000915 active site 358681000916 Mn binding site [ion binding]; other site 358681000917 oligomer interface [polypeptide binding]; other site 358681000918 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 358681000919 Predicted transmembrane transcriptional regulator (anti-sigma factor) [Transcription]; Region: COG5662 358681000920 Putative zinc-finger; Region: zf-HC2; pfam13490 358681000921 Polymer-forming cytoskeletal; Region: Bactofilin; pfam04519 358681000922 Uncharacterized conserved protein [Function unknown]; Region: COG1624 358681000923 DisA bacterial checkpoint controller nucleotide-binding; Region: DisA_N; pfam02457 358681000924 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4856 358681000925 YbbR-like protein; Region: YbbR; pfam07949 358681000926 YbbR-like protein; Region: YbbR; pfam07949 358681000927 phosphoglucosamine mutase; Provisional; Region: glmM; PRK14316 358681000928 GlmM is a bacterial phosphoglucosamine mutase (PNGM) that belongs to the alpha-D-phosphohexomutase superfamily. It is required for the interconversion of glucosamine-6-phosphate and glucosamine-1-phosphate in the biosynthetic pathway of...; Region: GlmM; cd05802 358681000929 active site 358681000930 substrate binding site [chemical binding]; other site 358681000931 metal binding site [ion binding]; metal-binding site 358681000932 glucosamine--fructose-6-phosphate aminotransferase; Reviewed; Region: PRK00331 358681000933 Glutamine amidotransferases class-II (Gn-AT)_GFAT-type. This domain is found at the N-terminus of glucosamine-6P synthase (GlmS, or GFAT in humans). The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the appropriate substrate. In...; Region: GFAT; cd00714 358681000934 glutaminase active site [active] 358681000935 SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008 358681000936 dimer interface [polypeptide binding]; other site 358681000937 active site 358681000938 SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009 358681000939 dimer interface [polypeptide binding]; other site 358681000940 active site 358681000941 Protein of unknown function (DUF2892); Region: DUF2892; pfam11127 358681000942 Carboxymuconolactone decarboxylase family; Region: CMD; cl00460 358681000943 Integrase core domain; Region: rve; pfam00665 358681000944 Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050 358681000945 IS66 C-terminal element; Region: DDE_Tnp_IS66_C; pfam13817 358681000946 Ketosteroid isomerase-related protein [General function prediction only]; Region: COG3631 358681000947 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436 358681000948 putative Helix-turn-helix domain of transposase IS66; Region: HTH_Tnp_IS66; pfam13005 358681000949 Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050 358681000950 P-type DNA transfer ATPase VirB11; Region: VirB11; TIGR02788 358681000951 Bacterial conjugation TrbI-like protein; Region: TrbI; pfam03743 358681000952 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cl17257 358681000953 DNA binding residues [nucleotide binding] 358681000954 TIR domain; Region: TIR_2; pfam13676 358681000955 glycerophosphodiester phosphodiesterase; Provisional; Region: glpQ; PRK11143 358681000956 Glycerophosphodiester phosphodiesterase domain of Escherichia coli (GlpQ) and similar proteins; Region: GDPD_EcGlpQ_like; cd08600 358681000957 active site 358681000958 catalytic site [active] 358681000959 metal binding site [ion binding]; metal-binding site 358681000960 Antibiotic biosynthesis monooxygenase; Region: ABM; cl10022 358681000961 Nitroreductase-like family 1. A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes, nitrofurans and...; Region: Nitroreductase_1; cd02137 358681000962 dimer interface [polypeptide binding]; other site 358681000963 FMN binding site [chemical binding]; other site 358681000964 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 358681000965 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 358681000966 dimerization interface [polypeptide binding]; other site 358681000967 putative DNA binding site [nucleotide binding]; other site 358681000968 putative Zn2+ binding site [ion binding]; other site 358681000969 germination protein, Ger(x)C family; Region: spore_ger_x_C; TIGR02887 358681000970 Spore germination B3/ GerAC like, C-terminal; Region: Spore_GerAC; pfam05504 358681000971 Spore germination protein; Region: Spore_permease; pfam03845 358681000972 Bacillus/Clostridium GerA spore germination protein; Region: GerA; pfam03323 358681000973 sn-glycerol-3-phosphate transporter; Provisional; Region: glpT; PRK11273 358681000974 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 358681000975 putative substrate translocation pore; other site 358681000976 chitin-binding domain of Chi A1-like proteins; Region: ChiA1_BD; cd12214 358681000977 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 358681000978 Interdomain contacts; other site 358681000979 Cytokine receptor motif; other site 358681000980 GH18 domain of Chitinase D (ChiD). ChiD, a chitinase found in Bacillus circulans, hydrolyzes the 1,4-beta-linkages of N-acetylglucosamine in chitin and chitodextrins. The domain architecture of ChiD includes a catalytic glycosyl hydrolase family 18; Region: GH18_chitinase_D-like; cd02871 358681000981 Glycosyl hydrolases family 18; Region: Glyco_hydro_18; pfam00704 358681000982 putative active site [active] 358681000983 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 358681000984 dimerization interface [polypeptide binding]; other site 358681000985 putative DNA binding site [nucleotide binding]; other site 358681000986 putative Zn2+ binding site [ion binding]; other site 358681000987 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 358681000988 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 358681000989 putative substrate translocation pore; other site 358681000990 MAEBL; Provisional; Region: PTZ00121 358681000991 Cache domain; Region: Cache_1; pfam02743 358681000992 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 358681000993 dimerization interface [polypeptide binding]; other site 358681000994 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 358681000995 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 358681000996 dimer interface [polypeptide binding]; other site 358681000997 putative CheW interface [polypeptide binding]; other site 358681000998 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 358681000999 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 358681001000 putative luciferase-like monooxygenase, FMN-dependent, CE1758 family; Region: LLM_CE1758_fam; TIGR04036 358681001001 probable oxidoreductase, LLM family; Region: LLM_2I7G; TIGR03858 358681001002 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312 358681001003 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 358681001004 Uncharacterized homolog of gamma-carboxymuconolactone decarboxylase subunit [Function unknown]; Region: COG0599 358681001005 putative transport protein YifK; Provisional; Region: PRK10746 358681001006 Predicted membrane protein [Function unknown]; Region: COG2322 358681001007 Macrolide 2'-Phosphotransferase (MPH2'). MPH2' is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs), RIO kinases, actin-fragmin kinase; Region: MPH2' cd05152 358681001008 Phosphotransferase enzyme family; Region: APH; pfam01636 358681001009 putative active site [active] 358681001010 putative substrate binding site [chemical binding]; other site 358681001011 ATP binding site [chemical binding]; other site 358681001012 Human Ape1-like subfamily of the ExoIII family purinic/apyrimidinic (AP) endonucleases; Region: Ape1-like_AP-endo; cd09087 358681001013 active site 358681001014 putative catalytic site [active] 358681001015 DNA binding site [nucleotide binding] 358681001016 putative phosphate binding site [ion binding]; other site 358681001017 metal binding site A [ion binding]; metal-binding site 358681001018 AP binding site [nucleotide binding]; other site 358681001019 metal binding site B [ion binding]; metal-binding site 358681001020 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 358681001021 Domain of unknown function DUF21; Region: DUF21; pfam01595 358681001022 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 358681001023 Transporter associated domain; Region: CorC_HlyC; pfam03471 358681001024 Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5; Region: DHFR; cl17426 358681001025 folate binding site [chemical binding]; other site 358681001026 NADP+ binding site [chemical binding]; other site 358681001027 FOG: HEAT repeat [Energy production and conversion]; Region: COG1413 358681001028 hypothetical protein; Validated; Region: PRK07581 358681001029 Homoserine acetyltransferase [Amino acid transport and metabolism]; Region: MET2; COG2021 358681001030 Helix-Turn-Helix DNA binding domain of the BmrR transcription regulator; Region: HTH_BmrR; cd01107 358681001031 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 358681001032 DNA binding residues [nucleotide binding] 358681001033 drug binding residues [chemical binding]; other site 358681001034 dimer interface [polypeptide binding]; other site 358681001035 GyrI-like small molecule binding domain; Region: GyrI-like; cl01368 358681001036 Putative cyclase; Region: Cyclase; pfam04199 358681001037 Metal binding domain of Ada; Region: Ada_Zn_binding; pfam02805 358681001038 endonuclease IV; Provisional; Region: PRK01060 358681001039 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cd00019 358681001040 AP (apurinic/apyrimidinic) site pocket; other site 358681001041 DNA interaction; other site 358681001042 Metal-binding active site; metal-binding site 358681001043 8-oxoguanine DNA glycosylase, N-terminal domain; Region: OGG_N; pfam07934 358681001044 3-methyladenine DNA glycosylase/8-oxoguanine DNA glycosylase [DNA replication, recombination, and repair]; Region: AlkA; COG0122 358681001045 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 358681001046 minor groove reading motif; other site 358681001047 helix-hairpin-helix signature motif; other site 358681001048 substrate binding pocket [chemical binding]; other site 358681001049 active site 358681001050 Adenosine deaminase [Nucleotide transport and metabolism]; Region: Ada; COG2169 358681001051 Metal binding domain of Ada; Region: Ada_Zn_binding; pfam02805 358681001052 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 358681001053 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 358681001054 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 358681001055 Beta-eliminating lyase; Region: Beta_elim_lyase; pfam01212 358681001056 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 358681001057 catalytic residue [active] 358681001058 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 358681001059 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 358681001060 Coenzyme A binding pocket [chemical binding]; other site 358681001061 Uncharacterized protein conserved in bacteria [Function unknown]; Region: DinB; COG2318 358681001062 DinB superfamily; Region: DinB_2; pfam12867 358681001063 Nitroreductase-like family 1. A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes, nitrofurans and...; Region: Nitroreductase_1; cd02137 358681001064 dimer interface [polypeptide binding]; other site 358681001065 FMN binding site [chemical binding]; other site 358681001066 N-terminal domain of Sphingobium chlorophenolicum 2,6-dichloro-p-hydroquinone 1,2-dioxygenase (PcpA), and similar proteins; Region: PcpA_N_like; cd08346 358681001067 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 358681001068 Zn binding site [ion binding]; other site 358681001069 C-terminal domain of Sphingobium chlorophenolicum 2,6-dichloro-p-hydroquinone 1,2-dioxygenase (PcpA), and similar proteins; Region: PcpA_C_like; cd08347 358681001070 Zn binding site [ion binding]; other site 358681001071 Predicted esterase [General function prediction only]; Region: COG0400 358681001072 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 358681001073 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 358681001074 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 358681001075 active site 358681001076 phosphorylation site [posttranslational modification] 358681001077 intermolecular recognition site; other site 358681001078 dimerization interface [polypeptide binding]; other site 358681001079 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 358681001080 DNA binding site [nucleotide binding] 358681001081 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 358681001082 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 358681001083 dimerization interface [polypeptide binding]; other site 358681001084 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 358681001085 dimer interface [polypeptide binding]; other site 358681001086 phosphorylation site [posttranslational modification] 358681001087 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 358681001088 ATP binding site [chemical binding]; other site 358681001089 Mg2+ binding site [ion binding]; other site 358681001090 G-X-G motif; other site 358681001091 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 358681001092 dimerization interface [polypeptide binding]; other site 358681001093 putative DNA binding site [nucleotide binding]; other site 358681001094 putative Zn2+ binding site [ion binding]; other site 358681001095 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 358681001096 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 358681001097 metal-binding site [ion binding] 358681001098 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 358681001099 Soluble P-type ATPase [General function prediction only]; Region: COG4087 358681001100 ABC-type uncharacterized transport system, duplicated ATPase component [General function prediction only]; Region: COG4172 358681001101 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 358681001102 Walker A/P-loop; other site 358681001103 ATP binding site [chemical binding]; other site 358681001104 Q-loop/lid; other site 358681001105 ABC transporter signature motif; other site 358681001106 Walker B; other site 358681001107 D-loop; other site 358681001108 H-loop/switch region; other site 358681001109 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 358681001110 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 358681001111 Walker A/P-loop; other site 358681001112 ATP binding site [chemical binding]; other site 358681001113 Q-loop/lid; other site 358681001114 ABC transporter signature motif; other site 358681001115 Walker B; other site 358681001116 D-loop; other site 358681001117 H-loop/switch region; other site 358681001118 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 358681001119 Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726 358681001120 Catalytic NodB homology domain of rhizobial NodB-like proteins; Region: CE4_NodB_like_6s_7s; cd10917 358681001121 NodB motif; other site 358681001122 active site 358681001123 catalytic site [active] 358681001124 metal binding site [ion binding]; metal-binding site 358681001125 Predicted transcriptional regulator [Transcription]; Region: COG2378 358681001126 HTH domain; Region: HTH_11; pfam08279 358681001127 WYL domain; Region: WYL; pfam13280 358681001128 Uncharacterized protein conserved in bacteria [Function unknown]; Region: DinB; COG2318 358681001129 DinB superfamily; Region: DinB_2; pfam12867 358681001130 HerA helicase [Replication, recombination, and repair]; Region: COG0433 358681001131 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 358681001132 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 358681001133 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 358681001134 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 358681001135 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 358681001136 Periplasmic binding protein; Region: Peripla_BP_2; pfam01497 358681001137 intersubunit interface [polypeptide binding]; other site 358681001138 ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614 358681001139 Periplasmic binding protein FeuA. These proteins have predicted to function as initial receptors in ABC transport of metal ions in some eubacterial species. They belong to the TroA superfamily of periplasmic metal binding proteins that share a distinct...; Region: FeuA; cd01138 358681001140 putative ligand binding residues [chemical binding]; other site 358681001141 ABC-type enterobactin transport system, permease component [Inorganic ion transport and metabolism]; Region: FepG; COG4779 358681001142 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 358681001143 ABC-ATPase subunit interface; other site 358681001144 dimer interface [polypeptide binding]; other site 358681001145 putative PBP binding regions; other site 358681001146 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 358681001147 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 358681001148 ABC-ATPase subunit interface; other site 358681001149 dimer interface [polypeptide binding]; other site 358681001150 putative PBP binding regions; other site 358681001151 Predicted hydrolase of the alpha/beta superfamily [General function prediction only]; Region: COG2819 358681001152 Nitroreductase-like family which includes NADH oxidase and arsenite oxidiase. NADH oxidase catalyses the oxidation of NAD(P)H and accepts a wide broad range of compounds as electron acceptors, such as nitrocompound. Arsenite oxidase in a...; Region: Arsenite_oxidase; cd02135 358681001153 putative FMN binding site [chemical binding]; other site 358681001154 H+ Antiporter protein; Region: 2A0121; TIGR00900 358681001155 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 358681001156 putative substrate translocation pore; other site 358681001157 Protein of unknown function (DUF419); Region: DUF419; pfam04237 358681001158 PAS fold; Region: PAS; pfam00989 358681001159 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 358681001160 putative active site [active] 358681001161 Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain [Transcription / Signal transduction mechanisms]; Region: PspF; COG1221 358681001162 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 358681001163 Walker A motif; other site 358681001164 ATP binding site [chemical binding]; other site 358681001165 Walker B motif; other site 358681001166 arginine finger; other site 358681001167 H+/gluconate symporter and related permeases [Carbohydrate transport and metabolism / Amino acid transport and metabolism]; Region: GntT; COG2610 358681001168 fructuronate transporter; Provisional; Region: PRK10034; cl15264 358681001169 3-hydroxybutyrate dehydrogenase; Provisional; Region: PRK12429 358681001170 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 358681001171 NAD(P) binding site [chemical binding]; other site 358681001172 active site 358681001173 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 358681001174 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 358681001175 active site 358681001176 phosphorylation site [posttranslational modification] 358681001177 intermolecular recognition site; other site 358681001178 dimerization interface [polypeptide binding]; other site 358681001179 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 358681001180 DNA binding site [nucleotide binding] 358681001181 heavy metal sensor kinase; Region: cztS_silS_copS; TIGR01386 358681001182 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 358681001183 dimer interface [polypeptide binding]; other site 358681001184 phosphorylation site [posttranslational modification] 358681001185 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 358681001186 ATP binding site [chemical binding]; other site 358681001187 Mg2+ binding site [ion binding]; other site 358681001188 G-X-G motif; other site 358681001189 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4841 358681001190 N-acylamino acid racemase (NAAAR), an octameric enzyme that catalyzes the racemization of N-acylamino acids. NAAARs act on a broad range of N-acylamino acids rather than amino acids. Enantiopure amino acids are of industrial interest as chiral building...; Region: NAAAR; cd03317 358681001191 o-succinylbenzoate synthase; Region: menC_lowGC/arch; TIGR01928 358681001192 active site 358681001193 octamer interface [polypeptide binding]; other site 358681001194 M20 Peptidase Aminoacylase 1 amhX_like subfamily; Region: M20_Acy1_amhX_like; cd08018 358681001195 amidohydrolase; Region: amidohydrolases; TIGR01891 358681001196 metal binding site [ion binding]; metal-binding site 358681001197 putative dimer interface [polypeptide binding]; other site 358681001198 Predicted membrane protein [Function unknown]; Region: COG1288 358681001199 C4-dicarboxylate anaerobic carrier; Region: DcuC; pfam03606 358681001200 PAS domain; Region: PAS; smart00091 358681001201 PAS domain; Region: PAS_9; pfam13426 358681001202 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 358681001203 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 358681001204 Walker A motif; other site 358681001205 ATP binding site [chemical binding]; other site 358681001206 Walker B motif; other site 358681001207 arginine finger; other site 358681001208 Ribonuclease R winged-helix domain; Region: HTH_12; pfam08461 358681001209 Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms]; Region: LytT; COG3279 358681001210 LytTr DNA-binding domain; Region: LytTR; smart00850 358681001211 Acetyl-CoA hydrolase/transferase N-terminal domain; Region: AcetylCoA_hydro; pfam02550 358681001212 succinate CoA transferase; Region: YgfH_subfam; TIGR03458 358681001213 Acetyl-CoA hydrolase/transferase C-terminal domain; Region: AcetylCoA_hyd_C; pfam13336 358681001214 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 358681001215 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 358681001216 putative substrate translocation pore; other site 358681001217 helix_turn_helix ASNC type; Region: HTH_ASNC; smart00344 358681001218 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 358681001219 putative DNA binding site [nucleotide binding]; other site 358681001220 putative Zn2+ binding site [ion binding]; other site 358681001221 AsnC family; Region: AsnC_trans_reg; pfam01037 358681001222 Cytochrome bd-type quinol oxidase, subunit 2 [Energy production and conversion]; Region: AppB; COG1294 358681001223 Bacterial Cytochrome Ubiquinol Oxidase; Region: Bac_Ubq_Cox; pfam01654 358681001224 Pirin; Region: Pirin; pfam02678 358681001225 Pirin C-terminal cupin domain; Region: Pirin_C; pfam05726 358681001226 Predicted membrane protein [Function unknown]; Region: COG2259 358681001227 azoreductase; Provisional; Region: PRK13556 358681001228 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 358681001229 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 358681001230 MarR family; Region: MarR; pfam01047 358681001231 Winged helix-turn-helix DNA-binding; Region: HTH_24; pfam13412 358681001232 putative kinase; Provisional; Region: PRK09954 358681001233 YeiC-like sugar kinase. Found in eukaryotes and bacteria, YeiC-like kinase is part of the ribokinase/pfkB sugar kinase superfamily. Its oligomerization state is unknown at this time; Region: YeiC_kinase_like; cd01941 358681001234 substrate binding site [chemical binding]; other site 358681001235 ATP binding site [chemical binding]; other site 358681001236 Indigoidine synthase A like protein; Region: Indigoidine_A; pfam04227 358681001237 Glycopeptide antibiotics resistance protein [Defense mechanisms]; Region: VanZ; COG4767 358681001238 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 358681001239 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 358681001240 metal-binding site [ion binding] 358681001241 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 358681001242 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 358681001243 metal-binding site [ion binding] 358681001244 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 358681001245 Soluble P-type ATPase [General function prediction only]; Region: COG4087 358681001246 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 358681001247 metal-binding site [ion binding] 358681001248 ABC-type proline/glycine betaine transport system, ATPase component [Amino acid transport and metabolism]; Region: ProV; COG4175 358681001249 ATP-binding cassette domain of the osmoprotectant proline/glycine betaine uptake system; Region: ABC_Pro_Gly_Betaine; cd03294 358681001250 Walker A/P-loop; other site 358681001251 ATP binding site [chemical binding]; other site 358681001252 Q-loop/lid; other site 358681001253 ABC transporter signature motif; other site 358681001254 Walker B; other site 358681001255 D-loop; other site 358681001256 H-loop/switch region; other site 358681001257 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in association with the ABC transporter OpuCA. OpuCA is the ATP binding component of a bacterial solute transporter that serves a protective role to cells growing...; Region: CBS_pair_ABC_OpuCA_assoc2; cd04583 358681001258 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 358681001259 dimer interface [polypeptide binding]; other site 358681001260 conserved gate region; other site 358681001261 putative PBP binding loops; other site 358681001262 ABC-ATPase subunit interface; other site 358681001263 ABC-type proline/glycine betaine transport systems, periplasmic components [Amino acid transport and metabolism]; Region: ProX; cl17891 358681001264 Substrate binding domain of ABC-type glycine betaine transport system; Region: OpuAC; pfam04069 358681001265 Substrate binding domain of ABC-type glycine betaine transport system; Region: OpuAC; pfam04069 358681001266 ABC-type proline/glycine betaine transport systems, periplasmic components [Amino acid transport and metabolism]; Region: ProX; cl17891 358681001267 Uncharacterized conserved protein (DUF2294); Region: DUF2294; pfam10057 358681001268 potassium-transporting ATPase subunit A; Provisional; Region: PRK05482 358681001269 potassium-transporting ATPase subunit B; Provisional; Region: PRK01122 358681001270 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 358681001271 Soluble P-type ATPase [General function prediction only]; Region: COG4087 358681001272 potassium-transporting ATPase subunit C; Reviewed; Region: PRK00315 358681001273 Osmosensitive K+ channel His kinase sensor domain; Region: KdpD; pfam02702 358681001274 USP domain is located between the N-terminal sensor domain and C-terminal catalytic domain of this Osmosensitive K+ channel histidine kinase family. The family of KdpD sensor kinase proteins regulates the kdpFABC operon responsible for potassium...; Region: USP_OKCHK; cd01987 358681001275 Ligand Binding Site [chemical binding]; other site 358681001276 Osmosensitive K+ channel histidine kinase [Signal transduction mechanisms]; Region: KdpD; COG2205 358681001277 Osmosensitive K+ channel His kinase sensor domain; Region: KdpD; pfam02702 358681001278 USP domain is located between the N-terminal sensor domain and C-terminal catalytic domain of this Osmosensitive K+ channel histidine kinase family. The family of KdpD sensor kinase proteins regulates the kdpFABC operon responsible for potassium...; Region: USP_OKCHK; cd01987 358681001279 Ligand Binding Site [chemical binding]; other site 358681001280 Arginase-like and histone-like hydrolases; Region: Arginase_HDAC; cl17011 358681001281 active site 358681001282 metal binding site [ion binding]; metal-binding site 358681001283 Domain of unknown function (DUF4179); Region: DUF4179; pfam13786 358681001284 DNA-directed RNA polymerase specialized sigma subunit, sigma24 homolog [Transcription]; Region: RpoE; COG1595 358681001285 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 358681001286 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 358681001287 DNA binding residues [nucleotide binding] 358681001288 Domain of unknown function (DUF4179); Region: DUF4179; pfam13786 358681001289 RNA polymerase sigma factor RpoE; Provisional; Region: PRK09652 358681001290 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 358681001291 Sigma-70, region 4; Region: Sigma70_r4_2; pfam08281 358681001292 DNA binding residues [nucleotide binding] 358681001293 Putative zinc-finger; Region: zf-HC2; pfam13490 358681001294 Domain of unknown function (DUF4179); Region: DUF4179; pfam13786 358681001295 Protein of unknown function with HXXEE motif; Region: HXXEE; pfam13787 358681001296 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 358681001297 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 358681001298 putative sporulation protein YtaF; Region: spore_YtaF; TIGR02840 358681001299 Domain of unknown function DUF; Region: DUF204; pfam02659 358681001300 Domain of unknown function DUF; Region: DUF204; pfam02659 358681001301 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: MgtA; COG0474 358681001302 Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; pfam00690 358681001303 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 358681001304 Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246 358681001305 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 358681001306 motif II; other site 358681001307 Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689 358681001308 Sporulation protein YunB (Spo_YunB); Region: Spore_YunB; cl09783 358681001309 Copper amine oxidase N-terminal domain; Region: Cu_amine_oxidN1; pfam07833 358681001310 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 358681001311 PAS domain; Region: PAS_9; pfam13426 358681001312 putative active site [active] 358681001313 heme pocket [chemical binding]; other site 358681001314 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920 358681001315 Histidine kinase; Region: HisKA_3; pfam07730 358681001316 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 358681001317 ATP binding site [chemical binding]; other site 358681001318 Mg2+ binding site [ion binding]; other site 358681001319 G-X-G motif; other site 358681001320 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 358681001321 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 358681001322 active site 358681001323 phosphorylation site [posttranslational modification] 358681001324 intermolecular recognition site; other site 358681001325 dimerization interface [polypeptide binding]; other site 358681001326 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 358681001327 DNA binding residues [nucleotide binding] 358681001328 dimerization interface [polypeptide binding]; other site 358681001329 Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; pfam00116 358681001330 Heme/copper-type cytochrome/quinol oxidases, subunit 2 [Energy production and conversion]; Region: CyoA; COG1622 358681001331 ba3-like heme-copper oxidase subunit I. The ba3 family of heme-copper oxidases are transmembrane protein complexes in the respiratory chains of prokaryotes and some archaea which catalyze the reduction of O2 and simultaneously pump protons across the...; Region: ba3-like_Oxidase_I; cd01660 358681001332 Putative D-pathway homolog; other site 358681001333 Cytochrome C and Quinol oxidase polypeptide I; Region: COX1; pfam00115 358681001334 Low-spin heme binding site [chemical binding]; other site 358681001335 Subunit I/II interface [polypeptide binding]; other site 358681001336 Putative Q-pathway; other site 358681001337 Putative alternate electron transfer pathway; other site 358681001338 Putative water exit pathway; other site 358681001339 Binuclear center (active site) [active] 358681001340 Putative K-pathway homolog; other site 358681001341 Putative proton exit pathway; other site 358681001342 Subunit I/IIa interface [polypeptide binding]; other site 358681001343 Electron transfer pathway; other site 358681001344 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 358681001345 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK05565 358681001346 NAD(P) binding site [chemical binding]; other site 358681001347 active site 358681001348 Nitroreductase-like family 1. A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes, nitrofurans and...; Region: Nitroreductase_1; cd02137 358681001349 dimer interface [polypeptide binding]; other site 358681001350 FMN binding site [chemical binding]; other site 358681001351 Histidinol dehydrogenase, HisD, E.C 1.1.1.23. Histidinol dehydrogenase catalyzes the last two steps in the L-histidine biosynthesis pathway, which is conserved in bacteria, archaea, fungi, and plants. These last two steps are (i) the NAD-dependent...; Region: Histidinol_dh; cl10029 358681001352 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 358681001353 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 358681001354 dimerization interface [polypeptide binding]; other site 358681001355 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 358681001356 dimer interface [polypeptide binding]; other site 358681001357 phosphorylation site [posttranslational modification] 358681001358 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 358681001359 ATP binding site [chemical binding]; other site 358681001360 Mg2+ binding site [ion binding]; other site 358681001361 G-X-G motif; other site 358681001362 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 358681001363 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 358681001364 active site 358681001365 phosphorylation site [posttranslational modification] 358681001366 intermolecular recognition site; other site 358681001367 dimerization interface [polypeptide binding]; other site 358681001368 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 358681001369 DNA binding site [nucleotide binding] 358681001370 Putative GTPases (G3E family) [General function prediction only]; Region: COG0523 358681001371 CobW/HypB/UreG, nucleotide-binding domain; Region: cobW; pfam02492 358681001372 Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; smart00833 358681001373 50S ribosomal protein L33; Validated; Region: rpmG; PRK00595 358681001374 glycerate kinase; Region: TIGR00045 358681001375 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; COG0475 358681001376 Sodium/hydrogen exchanger family; Region: Na_H_Exchanger; pfam00999 358681001377 Mannose-6-phosphate isomerase [Carbohydrate transport and metabolism]; Region: {ManC}; COG0662 358681001378 helix_turn_helix ASNC type; Region: HTH_ASNC; smart00344 358681001379 AsnC-type helix-turn-helix domain; Region: HTH_AsnC-type; pfam13404 358681001380 AsnC family; Region: AsnC_trans_reg; pfam01037 358681001381 Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220 358681001382 Beta-lactamase superfamily domain; Region: Lactamase_B_2; pfam12706 358681001383 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 358681001384 putative DNA binding site [nucleotide binding]; other site 358681001385 putative Zn2+ binding site [ion binding]; other site 358681001386 Clp protease; Region: CLP_protease; pfam00574 358681001387 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017 358681001388 oligomer interface [polypeptide binding]; other site 358681001389 active site residues [active] 358681001390 CHASE3 domain; Region: CHASE3; cl05000 358681001391 Four helix bundle sensory module for signal transduction; Region: 4HB_MCP_1; pfam12729 358681001392 Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840 358681001393 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 358681001394 dimerization interface [polypeptide binding]; other site 358681001395 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 358681001396 dimer interface [polypeptide binding]; other site 358681001397 putative CheW interface [polypeptide binding]; other site 358681001398 Predicted membrane-bound metal-dependent hydrolase (DUF457); Region: DUF457; cl00868 358681001399 Transcriptional regulator [Transcription]; Region: LysR; COG0583 358681001400 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 358681001401 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 358681001402 dimerization interface [polypeptide binding]; other site 358681001403 Predicted membrane protein [Function unknown]; Region: COG2311 358681001404 Protein of unknown function (DUF418); Region: DUF418; cl12135 358681001405 Protein of unknown function (DUF418); Region: DUF418; pfam04235 358681001406 Bacillus subtilis (Bs) citrate synthase CS-I_like. CS catalyzes the condensation of acetyl coenzyme A (AcCoA) and oxalacetate (OAA) to form citrate and coenzyme A (CoA), the first step in the citric acid cycle (TCA or Krebs cycle). 2MCS catalyzes the...; Region: BsCS-I_like; cd06109 358681001407 dimer interface [polypeptide binding]; other site 358681001408 Citrate synthase; Region: Citrate_synt; pfam00285 358681001409 active site 358681001410 citrylCoA binding site [chemical binding]; other site 358681001411 oxalacetate/citrate binding site [chemical binding]; other site 358681001412 coenzyme A binding site [chemical binding]; other site 358681001413 catalytic triad [active] 358681001414 NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902 358681001415 Old yellow enzyme (OYE) YqjM-like FMN binding domain. YqjM is involved in the oxidative stress response of Bacillus subtilis. Like the other OYE members, each monomer of YqjM contains FMN as a non-covalently bound cofactor and uses NADPH as a reducing...; Region: OYE_YqiM_FMN; cd02932 358681001416 active site 358681001417 FMN binding site [chemical binding]; other site 358681001418 substrate binding site [chemical binding]; other site 358681001419 homotetramer interface [polypeptide binding]; other site 358681001420 catalytic residue [active] 358681001421 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 358681001422 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 358681001423 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 358681001424 Major Facilitator Superfamily; Region: MFS_1; pfam07690 358681001425 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 358681001426 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 358681001427 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 358681001428 DNA-binding site [nucleotide binding]; DNA binding site 358681001429 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 358681001430 pyridoxal 5'-phosphate binding site [chemical binding]; other site 358681001431 homodimer interface [polypeptide binding]; other site 358681001432 catalytic residue [active] 358681001433 Predicted hydrolases of the HAD superfamily [General function prediction only]; Region: Cof; COG0561 358681001434 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 358681001435 active site 358681001436 motif I; other site 358681001437 motif II; other site 358681001438 A family including aminopeptidase P, aminopeptidase M, and prolidase. Also known as metallopeptidase family M24. This family of enzymes is able to cleave amido-, imido- and amidino-containing bonds. Members exibit relatively narrow substrate specificity...; Region: APP_MetAP; cd01066 358681001439 active site 358681001440 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 358681001441 ABC-2 type transporter; Region: ABC2_membrane; cl17235 358681001442 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 358681001443 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 358681001444 Walker A/P-loop; other site 358681001445 ATP binding site [chemical binding]; other site 358681001446 Q-loop/lid; other site 358681001447 ABC transporter signature motif; other site 358681001448 Walker B; other site 358681001449 D-loop; other site 358681001450 H-loop/switch region; other site 358681001451 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 358681001452 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 358681001453 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 358681001454 dimerization interface [polypeptide binding]; other site 358681001455 putative DNA binding site [nucleotide binding]; other site 358681001456 putative Zn2+ binding site [ion binding]; other site 358681001457 Domain of unknown function (DUF4129); Region: DUF4129; pfam13559 358681001458 Uncharacterized conserved protein (some members contain a von Willebrand factor type A (vWA) domain) [General function prediction only]; Region: COG1721 358681001459 Protein of unknown function DUF58; Region: DUF58; pfam01882 358681001460 MoxR-like ATPases [General function prediction only]; Region: COG0714 358681001461 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 358681001462 Walker A motif; other site 358681001463 ATP binding site [chemical binding]; other site 358681001464 Walker B motif; other site 358681001465 arginine finger; other site 358681001466 H+ Antiporter protein; Region: 2A0121; TIGR00900 358681001467 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 358681001468 putative substrate translocation pore; other site 358681001469 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 358681001470 dimerization interface [polypeptide binding]; other site 358681001471 putative DNA binding site [nucleotide binding]; other site 358681001472 putative Zn2+ binding site [ion binding]; other site 358681001473 O-acetylhomoserine aminocarboxypropyltransferase; Validated; Region: PRK08248 358681001474 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 358681001475 homodimer interface [polypeptide binding]; other site 358681001476 substrate-cofactor binding pocket; other site 358681001477 pyridoxal 5'-phosphate binding site [chemical binding]; other site 358681001478 catalytic residue [active] 358681001479 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 358681001480 active site residue [active] 358681001481 Uncharacterized protein SCO1/SenC/PrrC, involved in biogenesis of respiratory and photosynthetic systems [General function prediction only]; Region: COG1999 358681001482 SCO (an acronym for Synthesis of Cytochrome c Oxidase) family; composed of proteins similar to Sco1, a membrane-anchored protein possessing a soluble domain with a TRX fold. Members of this family are required for the proper assembly of cytochrome c...; Region: SCO; cd02968 358681001483 Cu(I) binding site [ion binding]; other site 358681001484 Protein of unknown function (DUF3889); Region: DUF3889; pfam13028 358681001485 mRNA degradation ribonucleases J1/J2 (metallo-beta-lactamase superfamily) [Translation, ribosomal structure and biogenesis; Replication, recombination and repair]; Region: COG0595 358681001486 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 358681001487 RNA-metabolising metallo-beta-lactamase; Region: RMMBL; pfam07521 358681001488 bacillithiol system oxidoreductase, YphP/YqiW family; Region: YphP_YqiW; TIGR04191 358681001489 classical (c) SDRs; Region: SDR_c; cd05233 358681001490 KR domain; Region: KR; pfam08659 358681001491 NAD(P) binding site [chemical binding]; other site 358681001492 active site 358681001493 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 358681001494 Major Facilitator Superfamily; Region: MFS_1; pfam07690 358681001495 putative substrate translocation pore; other site 358681001496 Transcriptional regulator [Transcription]; Region: LytR; COG1316 358681001497 Bacillus/Clostridium GerA spore germination protein; Region: GerA; pfam03323 358681001498 Spore germination protein; Region: Spore_permease; pfam03845 358681001499 germination protein, Ger(x)C family; Region: spore_ger_x_C; TIGR02887 358681001500 Spore germination B3/ GerAC like, C-terminal; Region: Spore_GerAC; pfam05504 358681001501 DL-methionine transporter ATP-binding subunit; Provisional; Region: metN; PRK11153 358681001502 ATP-binding cassette domain of methionine transporter; Region: ABC_MetN_methionine_transporter; cd03258 358681001503 Walker A/P-loop; other site 358681001504 ATP binding site [chemical binding]; other site 358681001505 Q-loop/lid; other site 358681001506 ABC transporter signature motif; other site 358681001507 Walker B; other site 358681001508 D-loop; other site 358681001509 H-loop/switch region; other site 358681001510 NIL domain; Region: NIL; pfam09383 358681001511 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 358681001512 dimer interface [polypeptide binding]; other site 358681001513 conserved gate region; other site 358681001514 ABC-ATPase subunit interface; other site 358681001515 ABC-type metal ion transport system, periplasmic component/surface antigen [Inorganic ion transport and metabolism]; Region: NlpA; COG1464 358681001516 NLPA lipoprotein; Region: Lipoprotein_9; pfam03180 358681001517 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 358681001518 The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504 358681001519 peptide binding site [polypeptide binding]; other site 358681001520 Putative hydrophobic ligand-binding SRPBCC domain of an uncharacterized subgroup of CalC- and Aha1-like proteins; some contain an N-terminal GntR family winged HTH DNA-binding domain; Region: SRPBCC_CalC_Aha1-like_GntR-HTH; cd08893 358681001521 putative hydrophobic ligand binding site [chemical binding]; other site 358681001522 Helix-turn-helix domain; Region: HTH_18; pfam12833 358681001523 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 358681001524 The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504 358681001525 peptide binding site [polypeptide binding]; other site 358681001526 Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496 358681001527 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 358681001528 The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504 358681001529 peptide binding site [polypeptide binding]; other site 358681001530 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 358681001531 The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504 358681001532 peptide binding site [polypeptide binding]; other site 358681001533 Copper amine oxidase N-terminal domain; Region: Cu_amine_oxidN1; pfam07833 358681001534 Copper amine oxidase N-terminal domain; Region: Cu_amine_oxidN1; pfam07833 358681001535 AMIN domain; Region: AMIN; pfam11741 358681001536 N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860 358681001537 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 358681001538 active site 358681001539 metal binding site [ion binding]; metal-binding site 358681001540 Sporulation and spore germination; Region: Germane; pfam10646 358681001541 Domain of unknown function (DUF378); Region: DUF378; pfam04070 358681001542 PBP superfamily domain; Region: PBP_like_2; cl17296 358681001543 Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531 358681001544 ABC-type phosphate transport system, permease component [Inorganic ion transport and metabolism]; Region: PstC; COG0573 358681001545 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 358681001546 dimer interface [polypeptide binding]; other site 358681001547 conserved gate region; other site 358681001548 putative PBP binding loops; other site 358681001549 ABC-ATPase subunit interface; other site 358681001550 ABC-type phosphate transport system, permease component [Inorganic ion transport and metabolism]; Region: PstA; COG0581 358681001551 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 358681001552 dimer interface [polypeptide binding]; other site 358681001553 conserved gate region; other site 358681001554 putative PBP binding loops; other site 358681001555 ABC-ATPase subunit interface; other site 358681001556 ABC-type phosphate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: PstB; COG1117 358681001557 ATP-binding cassette domain of the phosphate transport system; Region: ABC_PstB_phosphate_transporter; cd03260 358681001558 Walker A/P-loop; other site 358681001559 ATP binding site [chemical binding]; other site 358681001560 Q-loop/lid; other site 358681001561 ABC transporter signature motif; other site 358681001562 Walker B; other site 358681001563 D-loop; other site 358681001564 H-loop/switch region; other site 358681001565 Cache domain; Region: Cache_1; pfam02743 358681001566 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 358681001567 dimerization interface [polypeptide binding]; other site 358681001568 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 358681001569 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 358681001570 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 358681001571 dimer interface [polypeptide binding]; other site 358681001572 putative CheW interface [polypeptide binding]; other site 358681001573 ABC-type phosphate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: PstB; COG1117 358681001574 ATP-binding cassette domain of the phosphate transport system; Region: ABC_PstB_phosphate_transporter; cd03260 358681001575 Walker A/P-loop; other site 358681001576 ATP binding site [chemical binding]; other site 358681001577 Q-loop/lid; other site 358681001578 ABC transporter signature motif; other site 358681001579 Walker B; other site 358681001580 D-loop; other site 358681001581 H-loop/switch region; other site 358681001582 Predicted transcriptional regulators [Transcription]; Region: COG1733 358681001583 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 358681001584 SnoaL-like polyketide cyclase; Region: SnoaL; pfam07366 358681001585 Flavodoxin-like fold; Region: Flavodoxin_2; pfam02525 358681001586 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 358681001587 short chain dehydrogenase; Provisional; Region: PRK07041 358681001588 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 358681001589 NAD(P) binding site [chemical binding]; other site 358681001590 active site 358681001591 arsenical pump membrane protein; Provisional; Region: PRK15445 358681001592 Anion permease ArsB. These permeases have been shown to export arsenate and antimonite in eubacteria and archaea. A typical ArsB permease contains 8-13 transmembrane helices and can function either independently as a chemiosmotic transporter or as a...; Region: ArsB_permease; cd01118 358681001593 transmembrane helices; other site 358681001594 Gluconate 2-dehydrogenase subunit 3; Region: Gluconate_2-dh3; pfam13618 358681001595 Choline dehydrogenase and related flavoproteins [Amino acid transport and metabolism]; Region: BetA; COG2303 358681001596 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 358681001597 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 358681001598 dimerization interface [polypeptide binding]; other site 358681001599 putative DNA binding site [nucleotide binding]; other site 358681001600 putative Zn2+ binding site [ion binding]; other site 358681001601 NrdH-redoxin (NrdH) family; NrdH is a small monomeric protein with a conserved redox active CXXC motif within a TRX fold, characterized by a glutaredoxin (GRX)-like sequence and TRX-like activity profile. In vitro, it displays protein disulfide reductase...; Region: NrdH; cd02976 358681001602 catalytic residues [active] 358681001603 4'-phosphopantetheinyl transferase; Provisional; Region: acpS; PRK00070 358681001604 Outer membrane lipoprotein-sorting protein [Cell envelope biogenesis, outer membrane]; Region: LolA; COG2834 358681001605 putative transposase OrfB; Reviewed; Region: PHA02517 358681001606 HTH-like domain; Region: HTH_21; pfam13276 358681001607 Integrase core domain; Region: rve; pfam00665 358681001608 Integrase core domain; Region: rve_3; pfam13683 358681001609 alanine racemase; Region: alr; TIGR00492 358681001610 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Alanine Racemase; Region: PLPDE_III_AR; cd00430 358681001611 active site 358681001612 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 358681001613 dimer interface [polypeptide binding]; other site 358681001614 substrate binding site [chemical binding]; other site 358681001615 catalytic residues [active] 358681001616 Predicted transcriptional regulators containing the CopG/Arc/MetJ DNA-binding domain and a metal-binding domain [Transcription]; Region: NikR; COG0864 358681001617 Uncharacterized protein family (UPF0156); Region: RHH_2; cl17383 358681001618 PemK-like protein; Region: PemK; pfam02452 358681001619 Histidine kinase-like ATPase domain; Region: HATPase_c_2; pfam13581 358681001620 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075 358681001621 ATP binding site [chemical binding]; other site 358681001622 G-X-G motif; other site 358681001623 Phosphoserine phosphatase RsbU, N-terminal domain; Region: RsbU_N; pfam08673 358681001624 Serine phosphatase RsbU, regulator of sigma subunit [Signal transduction mechanisms / Transcription]; Region: RsbU; COG2208 358681001625 Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228 358681001626 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 358681001627 anti sigma factor interaction site; other site 358681001628 Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659 358681001629 regulatory phosphorylation site [posttranslational modification]; other site 358681001630 Histidine kinase-like ATPase domain; Region: HATPase_c_2; pfam13581 358681001631 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 358681001632 ATP binding site [chemical binding]; other site 358681001633 Mg2+ binding site [ion binding]; other site 358681001634 G-X-G motif; other site 358681001635 RNA polymerase sigma factor SigB; Validated; Region: PRK08583 358681001636 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 358681001637 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 358681001638 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 358681001639 DNA binding residues [nucleotide binding] 358681001640 Transcriptional accessory protein [Transcription]; Region: Tex; COG2183 358681001641 Tex-like protein N-terminal domain; Region: Tex_N; pfam09371 358681001642 Likely ribonuclease with RNase H fold; Region: YqgFc; smart00732 358681001643 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 358681001644 RNA binding site [nucleotide binding]; other site 358681001645 hypothetical protein; Provisional; Region: PRK04351 358681001646 SprT homologues; Region: SprT; cl01182 358681001647 thiamine monophosphate kinase; Provisional; Region: PRK05731 358681001648 ThiL (Thiamine-monophosphate kinase) plays a dual role in de novo biosynthesis and in salvage of exogenous thiamine. Thiamine salvage occurs in two steps, with thiamine kinase catalyzing the formation of thiamine phosphate, and ThiL catalyzing the...; Region: ThiL; cd02194 358681001649 ATP binding site [chemical binding]; other site 358681001650 dimerization interface [polypeptide binding]; other site 358681001651 Predicted ATPase or kinase [General function prediction only]; Region: COG0802 358681001652 tRNA threonylcarbamoyl adenosine modification protein YeaZ; Region: T6A_YeaZ; TIGR03725 358681001653 Glycoprotease family; Region: Peptidase_M22; pfam00814 358681001654 ribosomal-protein-alanine acetyltransferase; Region: rimI; TIGR01575 358681001655 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 358681001656 Coenzyme A binding pocket [chemical binding]; other site 358681001657 UGMP family protein; Validated; Region: PRK09604 358681001658 tRNA threonylcarbamoyl adenosine modification protein YeaZ; Region: T6A_YeaZ; TIGR03725 358681001659 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 358681001660 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 358681001661 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 358681001662 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 358681001663 ABC transporter; Region: ABC_tran_2; pfam12848 358681001664 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 358681001665 5-formyltetrahydrofolate cyclo-ligase family; Region: 5-FTHF_cyc-lig; pfam01812 358681001666 5,10-methenyltetrahydrofolate synthetase; Region: MTHFS_bact; TIGR02727 358681001667 MogA_MoaB family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF) an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea; Region: MogA_MoaB; cd00886 358681001668 MPT binding site; other site 358681001669 trimer interface [polypeptide binding]; other site 358681001670 MoeA_like. This domain is similar to a domain found in a variety of proteins involved in biosynthesis of molybdopterin cofactor, like MoaB, MogA, and MoeA. There this domain is presumed to bind molybdopterin. The exact function of this subgroup is...; Region: MoeA_like; cd03522 358681001671 putative MPT binding site; other site 358681001672 twin arginine translocase protein A; Provisional; Region: tatA; PRK14861 358681001673 Sec-independent protein secretion pathway component TatC [Intracellular trafficking and secretion]; Region: TatC; COG0805 358681001674 Copper amine oxidase N-terminal domain; Region: Cu_amine_oxidN1; pfam07833 358681001675 Protein of unknown function (DUF2845); Region: DUF2845; pfam11006 358681001676 Uncharacterized protein with SCP/PR1 domains [Function unknown]; Region: COG2340 358681001677 SCP_bacterial: SCP-like extracellular protein domain, as found in bacteria and archaea. The wider family of SCP containing proteins includes plant pathogenesis-related protein 1 (PR-1), CRISPs, mammalian cysteine-rich secretory proteins, and allergen 5...; Region: SCP_bacterial; cd05379 358681001678 Chaperonin 10 Kd subunit (cpn10 or GroES); Cpn10 cooperates with chaperonin 60 (cpn60 or GroEL), an ATPase, to assist the folding and assembly of proteins and is found in eubacterial cytosol, as well as in the matrix of mitochondria and chloroplasts. It...; Region: cpn10; cd00320 358681001679 oligomerisation interface [polypeptide binding]; other site 358681001680 mobile loop; other site 358681001681 roof hairpin; other site 358681001682 chaperonin GroEL; Reviewed; Region: groEL; PRK12849 358681001683 GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344 358681001684 ring oligomerisation interface [polypeptide binding]; other site 358681001685 ATP/Mg binding site [chemical binding]; other site 358681001686 stacking interactions; other site 358681001687 hinge regions; other site 358681001688 Predicted hydrolase (HAD superfamily) [General function prediction only]; Region: COG1011 358681001689 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 358681001690 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 358681001691 motif II; other site 358681001692 MoxR-like ATPases [General function prediction only]; Region: COG0714 358681001693 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 358681001694 Walker A motif; other site 358681001695 ATP binding site [chemical binding]; other site 358681001696 Walker B motif; other site 358681001697 arginine finger; other site 358681001698 Uncharacterized conserved protein (some members contain a von Willebrand factor type A (vWA) domain) [General function prediction only]; Region: COG1721 358681001699 Protein of unknown function DUF58; Region: DUF58; pfam01882 358681001700 Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305 358681001701 Transglutaminase-like superfamily; Region: Transglut_core; pfam01841 358681001702 Domain of unknown function (DUF4129); Region: DUF4129; pfam13559 358681001703 GMP synthase; Reviewed; Region: guaA; PRK00074 358681001704 Type 1 glutamine amidotransferase (GATase1) domain found in GMP synthetase; Region: GATase1_GMP_Synthase; cd01742 358681001705 AMP/PPi binding site [chemical binding]; other site 358681001706 candidate oxyanion hole; other site 358681001707 catalytic triad [active] 358681001708 potential glutamine specificity residues [chemical binding]; other site 358681001709 The C-terminal domain of GMP synthetase. It contains two subdomains; the ATP pyrophosphatase domain which closes to the N-termial and the dimerization domain at C-terminal end. The ATP-PPase is a twisted, five-stranded parallel beta-sheet sandwiched...; Region: GMP_synthase_C; cd01997 358681001710 ATP Binding subdomain [chemical binding]; other site 358681001711 Ligand Binding sites [chemical binding]; other site 358681001712 Dimerization subdomain; other site 358681001713 Xanthine/uracil/vitamin C permease [Nucleotide transport and metabolism]; Region: COG2252 358681001714 histidyl-tRNA synthetase; Provisional; Region: PRK12420 358681001715 Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for...; Region: HisRS-like_core; cd00773 358681001716 dimer interface [polypeptide binding]; other site 358681001717 motif 1; other site 358681001718 active site 358681001719 motif 2; other site 358681001720 motif 3; other site 358681001721 HisRS Histidyl-anticodon binding domain. HisRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: HisRS_anticodon; cd00859 358681001722 anticodon binding site; other site 358681001723 Peptidase M1 family containing bacterial Aminopeptidase N; Region: M1_APN_5; cd09604 358681001724 Zn binding site [ion binding]; other site 358681001725 Peptidase M1 family containing bacterial Aminopeptidase N; Region: M1_APN_5; cd09604 358681001726 Zn binding site [ion binding]; other site 358681001727 Phosphoribosylcarboxyaminoimidazole (NCAIR) mutase [Nucleotide transport and metabolism]; Region: PurE; COG0041 358681001728 phosphoribosylaminoimidazole carboxylase ATPase subunit; Reviewed; Region: PRK06019 358681001729 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain; Region: 2-Hacid_dh_C; pfam02826 358681001730 ATP-grasp domain; Region: ATP-grasp; pfam02222 358681001731 adenylosuccinate lyase; Provisional; Region: PRK07492 358681001732 Adenylsuccinate lyase (ASL)_subgroup 1; Region: Adenylsuccinate_lyase_1; cd01360 358681001733 tetramer interface [polypeptide binding]; other site 358681001734 active site 358681001735 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 358681001736 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 358681001737 RNA polymerase sigma-70 factor, TIGR02952 family; Region: Sig70_famx2 358681001738 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 358681001739 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 358681001740 DNA binding residues [nucleotide binding] 358681001741 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 358681001742 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 358681001743 active site 358681001744 phosphorylation site [posttranslational modification] 358681001745 intermolecular recognition site; other site 358681001746 dimerization interface [polypeptide binding]; other site 358681001747 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 358681001748 DNA binding site [nucleotide binding] 358681001749 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 358681001750 His Kinase A (phosphoacceptor) domain; Region: HisKA; smart00388 358681001751 dimer interface [polypeptide binding]; other site 358681001752 phosphorylation site [posttranslational modification] 358681001753 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 358681001754 ATP binding site [chemical binding]; other site 358681001755 Mg2+ binding site [ion binding]; other site 358681001756 G-X-G motif; other site 358681001757 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 358681001758 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 358681001759 Walker A/P-loop; other site 358681001760 ATP binding site [chemical binding]; other site 358681001761 Q-loop/lid; other site 358681001762 ABC transporter signature motif; other site 358681001763 Walker B; other site 358681001764 D-loop; other site 358681001765 H-loop/switch region; other site 358681001766 Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285 358681001767 nucleoside/Zn binding site; other site 358681001768 dimer interface [polypeptide binding]; other site 358681001769 catalytic motif [active] 358681001770 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 358681001771 AsnC-type helix-turn-helix domain; Region: HTH_AsnC-type; pfam13404 358681001772 putative DNA binding site [nucleotide binding]; other site 358681001773 putative Zn2+ binding site [ion binding]; other site 358681001774 AsnC family; Region: AsnC_trans_reg; pfam01037 358681001775 Chromate transport protein ChrA [Inorganic ion transport and metabolism]; Region: ChrA; COG2059 358681001776 Chromate transport protein ChrA [Inorganic ion transport and metabolism]; Region: ChrA; COG2059 358681001777 Gamma-glutamyltransferase [Amino acid transport and metabolism]; Region: Ggt; COG0405 358681001778 Gamma-glutamyltranspeptidase; Region: G_glu_transpept; pfam01019 358681001779 Response regulator receiver domain; Region: Response_reg; pfam00072 358681001780 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 358681001781 active site 358681001782 phosphorylation site [posttranslational modification] 358681001783 intermolecular recognition site; other site 358681001784 dimerization interface [polypeptide binding]; other site 358681001785 Response regulator receiver domain; Region: Response_reg; pfam00072 358681001786 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 358681001787 active site 358681001788 phosphorylation site [posttranslational modification] 358681001789 intermolecular recognition site; other site 358681001790 dimerization interface [polypeptide binding]; other site 358681001791 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 358681001792 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 358681001793 NAD(P) binding site [chemical binding]; other site 358681001794 active site 358681001795 Domain of unknown function (DUF4118); Region: DUF4118; pfam13493 358681001796 GAF domain; Region: GAF_3; pfam13492 358681001797 Uncharacterized protein conserved in bacteria (DUF2194); Region: DUF2194; pfam09960 358681001798 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4878 358681001799 Putative NodB-like catalytic domain of uncharacterized proteins found in bacteria; Region: CE4_COG4878; cd10924 358681001800 NodB motif; other site 358681001801 putative active site [active] 358681001802 putative catalytic site [active] 358681001803 putative Zn binding site [ion binding]; other site 358681001804 This family is most closely related to the GT1 family of glycosyltransferases. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can...; Region: GT1_like_3; cd03813 358681001805 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 358681001806 Predicted membrane protein [Function unknown]; Region: COG4267 358681001807 CotH protein; Region: CotH; pfam08757 358681001808 Polyphosphate(polyP) polymerase domain of yeast vacuolar transport chaperone (VTC) proteins VTC-2, -3 and- 4, and similar proteins; Region: PolyPPase_VTC_like; cd07750 358681001809 putative metal binding residues [ion binding]; other site 358681001810 signature motif; other site 358681001811 dimer interface [polypeptide binding]; other site 358681001812 active site 358681001813 polyP binding site; other site 358681001814 substrate binding site [chemical binding]; other site 358681001815 acceptor-phosphate pocket; other site 358681001816 Response regulator containing CheY-like receiver and SARP domains [Signal transduction mechanisms]; Region: COG3947 358681001817 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 358681001818 active site 358681001819 phosphorylation site [posttranslational modification] 358681001820 intermolecular recognition site; other site 358681001821 dimerization interface [polypeptide binding]; other site 358681001822 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cl17355 358681001823 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 358681001824 catalytic residues [active] 358681001825 Type II secretory pathway, prepilin signal peptidase PulO and related peptidases [Cell motility and secretion / Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: PulO; COG1989 358681001826 Type IV leader peptidase family; Region: Peptidase_A24; pfam01478 358681001827 SAF domains of the flagella basal body P-ring formation protein FlgA and the flp pilus assembly CpaB; Region: SAF_CpaB_FlgA_like; cd11614 358681001828 Response regulator receiver domain; Region: Response_reg; pfam00072 358681001829 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 358681001830 active site 358681001831 intermolecular recognition site; other site 358681001832 dimerization interface [polypeptide binding]; other site 358681001833 AAA domain; Region: AAA_31; pfam13614 358681001834 This protein family consists of proteins similar to the cpaE protein of the Caulobacter pilus assembly and the orf4 protein of Actinobacillus pilus formation gene cluster. The function of these proteins are unkown. The Caulobacter pilus assembly contains...; Region: CpaE_like; cd03111 358681001835 This protein family consists of proteins similar to the cpaE protein of the Caulobacter pilus assembly and the orf4 protein of Actinobacillus pilus formation gene cluster. The function of these proteins are unkown. The Caulobacter pilus assembly contains...; Region: CpaE_like; cd03111 358681001836 Flp pilus assembly protein, ATPase CpaF [Intracellular trafficking and secretion]; Region: CpaF; COG4962 358681001837 Type IV secretory pathway component VirB11, and related ATPases. The homohexamer, VirB11 is one of eleven Vir proteins, which are required for T-pilus biogenesis and virulence in the transfer of T-DNA from the Ti (tumor-inducing) plasmid of bacterial to...; Region: VirB11-like_ATPase; cd01130 358681001838 ATP binding site [chemical binding]; other site 358681001839 Walker A motif; other site 358681001840 hexamer interface [polypeptide binding]; other site 358681001841 Walker B motif; other site 358681001842 Flp pilus assembly protein TadB [Intracellular trafficking and secretion]; Region: TadB; COG4965 358681001843 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 358681001844 Flp pilus assembly protein TadC [Cell motility and secretion / Intracellular trafficking and secretion]; Region: TadC; COG2064 358681001845 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 358681001846 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057 358681001847 metal ion-dependent adhesion site (MIDAS); other site 358681001848 DNA translocase FtsK; Provisional; Region: PRK10263 358681001849 Uncharacterized protein family (UPF0259); Region: UPF0259; cl11642 358681001850 TadE-like protein; Region: TadE; pfam07811 358681001851 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057 358681001852 metal ion-dependent adhesion site (MIDAS); other site 358681001853 Uncharacterized ArCR, COG2043; Region: DUF169; pfam02596 358681001854 DinB superfamily; Region: DinB_2; pfam12867 358681001855 Protein of unknown function (DUF1569); Region: DUF1569; pfam07606 358681001856 Predicted transcriptional regulator [Transcription]; Region: COG2378 358681001857 HTH domain; Region: HTH_11; pfam08279 358681001858 WYL domain; Region: WYL; pfam13280 358681001859 D-alanyl-D-alanine carboxypeptidase [Cell envelope biogenesis, outer membrane]; Region: VanY; COG1876 358681001860 D-alanyl-D-alanine carboxypeptidase; Region: VanY; pfam02557 358681001861 D-alanyl-alanine synthetase A; Reviewed; Region: ddl; PRK01966 358681001862 D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820 358681001863 D-ala D-ala ligase C-terminus; Region: Dala_Dala_lig_C; pfam07478 358681001864 D-alanyl-D-alanine carboxypeptidase; Region: VanY; pfam02557 358681001865 Acyltransferase family; Region: Acyl_transf_3; pfam01757 358681001866 Predicted O-acyltransferase [General function prediction only]; Region: COG3274 358681001867 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes; Region: PLPDE_III; cl00261 358681001868 alanine racemase; Reviewed; Region: alr; PRK00053 358681001869 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 358681001870 catalytic residue [active] 358681001871 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 358681001872 HAMP domain; Region: HAMP; pfam00672 358681001873 dimerization interface [polypeptide binding]; other site 358681001874 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 358681001875 dimer interface [polypeptide binding]; other site 358681001876 phosphorylation site [posttranslational modification] 358681001877 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 358681001878 ATP binding site [chemical binding]; other site 358681001879 Mg2+ binding site [ion binding]; other site 358681001880 G-X-G motif; other site 358681001881 Uncharacterized protein with SCP/PR1 domains [Function unknown]; Region: COG2340 358681001882 SCP_bacterial: SCP-like extracellular protein domain, as found in bacteria and archaea. The wider family of SCP containing proteins includes plant pathogenesis-related protein 1 (PR-1), CRISPs, mammalian cysteine-rich secretory proteins, and allergen 5...; Region: SCP_bacterial; cd05379 358681001883 Leucyl aminopeptidase (aminopeptidase T) [Amino acid transport and metabolism]; Region: AmpS; COG2309 358681001884 Thermophilic metalloprotease (M29); Region: Peptidase_M29; pfam02073 358681001885 Uncharacterized oxidoreductases, Fe-dependent alcohol dehydrogenase family [Energy production and conversion]; Region: COG1979 358681001886 Dehydroquinate synthase-like (DHQ-like) and iron-containing alcohol dehydrogenases (Fe-ADH); Region: DHQ_Fe-ADH; cl02872 358681001887 active site 358681001888 NAD binding site [chemical binding]; other site 358681001889 metal binding site [ion binding]; metal-binding site 358681001890 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675 358681001891 Helix-turn-helix domain; Region: HTH_OrfB_IS605; pfam12323 358681001892 Probable transposase; Region: OrfB_IS605; pfam01385 358681001893 transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766 358681001894 phosphoribosylaminoimidazole-succinocarboxamide synthase; Reviewed; Region: PRK09362 358681001895 bacterial and archaeal 5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide (SAICAR) synthase; Region: SAICAR_synt_PurC; cd01415 358681001896 ATP binding site [chemical binding]; other site 358681001897 active site 358681001898 substrate binding site [chemical binding]; other site 358681001899 phosphoribosylformylglycinamidine synthase subunit PurS; Reviewed; Region: PRK05974 358681001900 phosphoribosylformylglycinamidine synthase I; Provisional; Region: PRK03619 358681001901 Type 1 glutamine amidotransferase (GATase1)-like domain found in Formylglycinamide ribonucleotide amidotransferase; Region: GATase1_FGAR_AT; cd01740 358681001902 putative active site [active] 358681001903 catalytic triad [active] 358681001904 phosphoribosylformylglycinamidine synthase II; Provisional; Region: PRK01213 358681001905 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), first repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat1; cd02203 358681001906 dimerization interface [polypeptide binding]; other site 358681001907 ATP binding site [chemical binding]; other site 358681001908 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), second repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat2; cd02204 358681001909 dimerization interface [polypeptide binding]; other site 358681001910 ATP binding site [chemical binding]; other site 358681001911 amidophosphoribosyltransferase; Provisional; Region: PRK07631 358681001912 Glutamine amidotransferases class-II (GN-AT)_GPAT- type. This domain is found at the N-terminus of glutamine phosphoribosylpyrophosphate (Prpp) amidotransferase (GPATase) . The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the...; Region: GPATase_N; cd00715 358681001913 active site 358681001914 tetramer interface [polypeptide binding]; other site 358681001915 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 358681001916 active site 358681001917 phosphoribosylaminoimidazole synthetase; Provisional; Region: PRK05385 358681001918 PurM (Aminoimidazole Ribonucleotide [AIR] synthetase), one of eleven enzymes required for purine biosynthesis, catalyzes the conversion of formylglycinamide ribonucleotide (FGAM) and ATP to AIR, ADP, and Pi, the fifth step in de novo purine biosynthesis; Region: PurM; cd02196 358681001919 dimerization interface [polypeptide binding]; other site 358681001920 putative ATP binding site [chemical binding]; other site 358681001921 phosphoribosylglycinamide formyltransferase; Reviewed; Region: purN; PRK05647 358681001922 Phosphoribosylglycinamide formyltransferase (GAR transformylase, GART); Region: FMT_core_GART; cd08645 358681001923 active site 358681001924 substrate binding site [chemical binding]; other site 358681001925 cosubstrate binding site; other site 358681001926 catalytic site [active] 358681001927 Mg2+ and Co2+ transporters [Inorganic ion transport and metabolism]; Region: CorA; COG0598 358681001928 uncharacterized bacterial subfamily of the Escherichia coli CorA-Salmonella typhimurium ZntB family; Region: EcCorA_ZntB-like_u2; cd12827 358681001929 Cl binding site [ion binding]; other site 358681001930 oligomer interface [polypeptide binding]; other site 358681001931 Family A polymerase primarily fills DNA gaps that arise during DNA repair, recombination and replication; Region: DNA_pol_A; cl02626 358681001932 bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; Provisional; Region: purH; PRK00881 358681001933 Inosine monophosphate cyclohydrolase domain. This is the N-terminal domain in the purine biosynthesis pathway protein ATIC (purH). The bifunctional ATIC protein contains a C-terminal ATIC formylase domain that formylates...; Region: IMPCH; cd01421 358681001934 purine monophosphate binding site [chemical binding]; other site 358681001935 dimer interface [polypeptide binding]; other site 358681001936 putative catalytic residues [active] 358681001937 AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; smart00798 358681001938 AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; cl03362 358681001939 phosphoribosylamine--glycine ligase; Provisional; Region: PRK00885 358681001940 Phosphoribosylglycinamide synthetase, N domain; Region: GARS_N; pfam02844 358681001941 Phosphoribosylglycinamide synthetase, ATP-grasp (A) domain; Region: GARS_A; pfam01071 358681001942 Phosphoribosylglycinamide synthetase, C domain; Region: GARS_C; pfam02843 358681001943 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 358681001944 Major Facilitator Superfamily; Region: MFS_1; pfam07690 358681001945 putative substrate translocation pore; other site 358681001946 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 358681001947 MarR family; Region: MarR; pfam01047 358681001948 Protein of unknown function (DUF2892); Region: DUF2892; pfam11127 358681001949 Adenine deaminase [Nucleotide transport and metabolism]; Region: AdeC; COG1001 358681001950 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 358681001951 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 358681001952 active site 358681001953 Adenine deaminase C-terminal domain; Region: Adenine_deam_C; pfam13382 358681001954 ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683 358681001955 Type I periplasmic ligand-binding domain of ABC (Atpase Binding Cassette)-type active transport systems that are involved in the transport of all three branched chain aliphatic amino acids (leucine, isoleucine and valine); Region: PBP1_ABC_LIVBP_like; cd06342 358681001956 dimerization interface [polypeptide binding]; other site 358681001957 ligand binding site [chemical binding]; other site 358681001958 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 358681001959 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 358681001960 TM-ABC transporter signature motif; other site 358681001961 ABC-type branched-chain amino acid transport system, permease component [Amino acid transport and metabolism]; Region: LivM; COG4177 358681001962 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 358681001963 TM-ABC transporter signature motif; other site 358681001964 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411 358681001965 ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219 358681001966 Walker A/P-loop; other site 358681001967 ATP binding site [chemical binding]; other site 358681001968 Q-loop/lid; other site 358681001969 ABC transporter signature motif; other site 358681001970 Walker B; other site 358681001971 D-loop; other site 358681001972 H-loop/switch region; other site 358681001973 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410 358681001974 ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224 358681001975 Walker A/P-loop; other site 358681001976 ATP binding site [chemical binding]; other site 358681001977 Q-loop/lid; other site 358681001978 ABC transporter signature motif; other site 358681001979 Walker B; other site 358681001980 D-loop; other site 358681001981 H-loop/switch region; other site 358681001982 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 358681001983 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 358681001984 DNA-binding site [nucleotide binding]; DNA binding site 358681001985 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 358681001986 pyridoxal 5'-phosphate binding site [chemical binding]; other site 358681001987 homodimer interface [polypeptide binding]; other site 358681001988 catalytic residue [active] 358681001989 nylC-like family; composed of proteins with similarity to Flavobacterium endo-type 6-aminohexanoate-oligomer hydrolase (EIII), the product of the nylon oligomer degradation gene, nylC. EIII is an amide hydrolase that catalyzes the degradation of...; Region: nylC_like; cd02252 358681001990 putative active site pocket [active] 358681001991 cleavage site 358681001992 Domain of unknown function (DUF4367); Region: DUF4367; pfam14285 358681001993 Transcriptional regulator [Transcription]; Region: IclR; COG1414 358681001994 helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346 358681001995 Bacterial transcriptional regulator; Region: IclR; pfam01614 358681001996 Spermidine/putrescine-binding periplasmic protein [Amino acid transport and metabolism]; Region: PotD; COG0687 358681001997 ABC-type Fe3+ transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: AfuA; COG1840 358681001998 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 358681001999 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 358681002000 Walker A/P-loop; other site 358681002001 ATP binding site [chemical binding]; other site 358681002002 Q-loop/lid; other site 358681002003 ABC transporter signature motif; other site 358681002004 Walker B; other site 358681002005 D-loop; other site 358681002006 H-loop/switch region; other site 358681002007 TOBE domain; Region: TOBE_2; pfam08402 358681002008 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 358681002009 dimer interface [polypeptide binding]; other site 358681002010 conserved gate region; other site 358681002011 putative PBP binding loops; other site 358681002012 ABC-ATPase subunit interface; other site 358681002013 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 358681002014 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 358681002015 dimer interface [polypeptide binding]; other site 358681002016 conserved gate region; other site 358681002017 putative PBP binding loops; other site 358681002018 ABC-ATPase subunit interface; other site 358681002019 glutamate carboxypeptidase; Reviewed; Region: PRK06133 358681002020 M20 Peptidase Glutamate carboxypeptidase, a periplasmic enzyme; Region: M20_CPDG2; cd03885 358681002021 metal binding site [ion binding]; metal-binding site 358681002022 dimer interface [polypeptide binding]; other site 358681002023 F5/8 type C domain; Region: F5_F8_type_C; pfam00754 358681002024 Carbohydrate Binding Module 6 (CBM6); appended to several carbohydrate binding enzymes, including several glycoside hydrolase (GH) family 26 mannanase domains; Region: CBM6_mannanase-like; cd04086 358681002025 F5/8 type C domain; Region: F5_F8_type_C; pfam00754 358681002026 sugar binding site [chemical binding]; other site 358681002027 Beta-xylosidase [Carbohydrate transport and metabolism]; Region: XynB; COG3507 358681002028 Domain of Unknown Function (DUF1080); Region: DUF1080; pfam06439 358681002029 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 358681002030 Peptidase family M23; Region: Peptidase_M23; pfam01551 358681002031 S-layer homology domain; Region: SLH; pfam00395 358681002032 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 358681002033 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 358681002034 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 358681002035 DNA binding residues [nucleotide binding] 358681002036 Thymidylate kinase [Nucleotide transport and metabolism]; Region: Tmk; COG0125 358681002037 thymidylate kinase; Provisional; Region: PRK13975; cl17243 358681002038 Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741 358681002039 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 358681002040 N-acetyl-D-glucosamine binding site [chemical binding]; other site 358681002041 catalytic residue [active] 358681002042 RNA polymerase sigma-70 factor, sigma-B/F/G subfamily; Region: SigBFG; TIGR02980 358681002043 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 358681002044 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 358681002045 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 358681002046 active site 358681002047 catalytic tetrad [active] 358681002048 Bacillus/Clostridium GerA spore germination protein; Region: GerA; pfam03323 358681002049 germination protein, Ger(x)C family; Region: spore_ger_x_C; TIGR02887 358681002050 Spore germination B3/ GerAC like, C-terminal; Region: Spore_GerAC; pfam05504 358681002051 Spore germination protein; Region: Spore_permease; cl17796 358681002052 inosine 5-monophosphate dehydrogenase; Validated; Region: PRK07107 358681002053 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 358681002054 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in the inosine 5' monophosphate dehydrogenase (IMPDH) protein. IMPDH is an essential enzyme that catalyzes the first step unique to GTP synthesis, playing a...; Region: CBS_pair_IMPDH_2; cd04602 358681002055 IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381 358681002056 active site 358681002057 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 358681002058 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 358681002059 dimerization interface [polypeptide binding]; other site 358681002060 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 358681002061 dimer interface [polypeptide binding]; other site 358681002062 phosphorylation site [posttranslational modification] 358681002063 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 358681002064 ATP binding site [chemical binding]; other site 358681002065 Mg2+ binding site [ion binding]; other site 358681002066 G-X-G motif; other site 358681002067 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 358681002068 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 358681002069 active site 358681002070 phosphorylation site [posttranslational modification] 358681002071 intermolecular recognition site; other site 358681002072 dimerization interface [polypeptide binding]; other site 358681002073 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 358681002074 DNA binding site [nucleotide binding] 358681002075 Protein of unknown function (DUF3048); Region: DUF3048; pfam11258 358681002076 Trp repressor protein; Region: Trp_repressor; cl17266 358681002077 PcrB family; Region: PcrB; pfam01884 358681002078 PcrB_like proteins. One member of this family, a protein from Archaeoglobus fulgidus, has been characterized as a (S)-3-O-geranylgeranylglyceryl phosphate synthase (AfGGGPS). AfGGGPS catalyzes the formation of an ether linkage between...; Region: PcrB_like; cd02812 358681002079 substrate binding site [chemical binding]; other site 358681002080 putative active site [active] 358681002081 dimer interface [polypeptide binding]; other site 358681002082 Putative zinc-finger; Region: zf-HC2; pfam13490 358681002083 Domain of unknown function (DUF4179); Region: DUF4179; pfam13786 358681002084 RNA polymerase sigma factor SigW; Provisional; Region: PRK09641 358681002085 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 358681002086 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 358681002087 DNA binding residues [nucleotide binding] 358681002088 Dinucleotide-utilizing enzymes involved in molybdopterin and thiamine biosynthesis family 2 [Coenzyme metabolism]; Region: ThiF; COG0476 358681002089 ThiF_MoeB_HesA. Family of E1-like enzymes involved in molybdopterin and thiamine biosynthesis family. The common reaction mechanism catalyzed by MoeB and ThiF, like other E1 enzymes, begins with a nucleophilic attack of the C-terminal carboxylate of MoaD...; Region: ThiF_MoeB_HesA_family; cd00757 358681002090 ATP binding site [chemical binding]; other site 358681002091 substrate interface [chemical binding]; other site 358681002092 Tetratrico peptide repeat; Region: TPR_5; pfam12688 358681002093 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 358681002094 binding surface 358681002095 TPR motif; other site 358681002096 Response regulator containing CheY-like receiver domain and AraC-type DNA-binding domain [Signal transduction mechanisms]; Region: COG4753 358681002097 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 358681002098 active site 358681002099 phosphorylation site [posttranslational modification] 358681002100 intermolecular recognition site; other site 358681002101 dimerization interface [polypeptide binding]; other site 358681002102 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 358681002103 Predicted signal transduction protein with a C-terminal ATPase domain [Signal transduction mechanisms]; Region: COG2972 358681002104 Cache domain; Region: Cache_1; pfam02743 358681002105 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 358681002106 dimerization interface [polypeptide binding]; other site 358681002107 Histidine kinase; Region: His_kinase; pfam06580 358681002108 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 358681002109 ATP binding site [chemical binding]; other site 358681002110 Mg2+ binding site [ion binding]; other site 358681002111 G-X-G motif; other site 358681002112 Periplasmic sugar-binding domain of uncharacterized ABC-type transport systems; Region: PBP1_ABC_sugar_binding_like_2; cd06310 358681002113 Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407 358681002114 putative ligand binding site [chemical binding]; other site 358681002115 methyl-galactoside ABC transporter galactose-binding periplasmic protein MglB; Provisional; Region: PRK15395 358681002116 Periplasmic glucose/galactose-binding protein (GGBP) involved in chemotaxis towards, and active transport of, glucose and galactose in various bacterial species; Region: PBP1_GGBP; cd01539 358681002117 ligand binding site [chemical binding]; other site 358681002118 calcium binding site [ion binding]; other site 358681002119 ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129 358681002120 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 358681002121 Walker A/P-loop; other site 358681002122 ATP binding site [chemical binding]; other site 358681002123 Q-loop/lid; other site 358681002124 ABC transporter signature motif; other site 358681002125 Walker B; other site 358681002126 D-loop; other site 358681002127 H-loop/switch region; other site 358681002128 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 358681002129 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 358681002130 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 358681002131 TM-ABC transporter signature motif; other site 358681002132 Predicted membrane protein [Function unknown]; Region: COG2311 358681002133 Protein of unknown function (DUF418); Region: DUF418; pfam04235 358681002134 VanW like protein; Region: VanW; pfam04294 358681002135 ATP-dependent DNA helicase PcrA; Region: pcrA; TIGR01073 358681002136 Part of AAA domain; Region: AAA_19; pfam13245 358681002137 Family description; Region: UvrD_C_2; pfam13538 358681002138 NAD-dependent DNA ligase LigA; Validated; Region: ligA; PRK07956 358681002139 NAD+ dependent DNA ligase adenylation domain. DNA ligases catalyze the crucial step of joining the breaks in duplex DNA during DNA replication, repair and recombination, utilizing either ATP or NAD(+) as a cofactor, but using the same basic reaction...; Region: LIGANc; cd00114 358681002140 nucleotide binding pocket [chemical binding]; other site 358681002141 K-X-D-G motif; other site 358681002142 catalytic site [active] 358681002143 NAD-dependent DNA ligase OB-fold domain; Region: DNA_ligase_OB; pfam03120 358681002144 NAD-dependent DNA ligase C4 zinc finger domain; Region: DNA_ligase_ZBD; pfam03119 358681002145 H3TH domains of structure-specific 5' nucleases (or flap endonuclease-1-like) involved in DNA replication, repair, and recombination; Region: H3TH_StructSpec-5'-nucleases; cl14815 358681002146 DNA binding site [nucleotide binding] 358681002147 Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo...; Region: BRCT; cd00027 358681002148 Dimer interface [polypeptide binding]; other site 358681002149 BRCT sequence motif; other site 358681002150 Ycf48-like protein; Provisional; Region: PRK13684 358681002151 Protein involved in sex pheromone biosynthesis [General function prediction only]; Region: CamS; COG4851 358681002152 N-terminal repeat domain of CamS sex pheromone cAM373 precursor; Region: CamS_repeat_1; cd13441 358681002153 putative dimer interface [polypeptide binding]; other site 358681002154 C-terminal repeat domain of CamS sex pheromone cAM373 precursor; Region: CamS_repeat_2; cd13440 358681002155 putative dimer interface [polypeptide binding]; other site 358681002156 1-pyrroline-5-carboxylate dehydrogenase; Provisional; Region: PRK03137 358681002157 Delta(1)-pyrroline-5-carboxylate dehydrogenase, RocA; Region: ALDH_PutA-P5CDH-RocA; cd07124 358681002158 Glutamate binding site [chemical binding]; other site 358681002159 homodimer interface [polypeptide binding]; other site 358681002160 NAD binding site [chemical binding]; other site 358681002161 catalytic residues [active] 358681002162 This subfamily contains Escherichia coli WecA, Bacillus subtilis TagO and related proteins. WecA is an UDP-N-acetylglucosamine (GlcNAc):undecaprenyl-phosphate (Und-P) GlcNAc-1-phosphate transferase that catalyzes the formation of a phosphodiester bond...; Region: GT_WecA_like; cd06853 358681002163 UDP-N-acetylmuramyl pentapeptide phosphotransferase/UDP-N- acetylglucosamine-1-phosphate transferase [Cell envelope biogenesis, outer membrane]; Region: Rfe; COG0472 358681002164 Mg++ binding site [ion binding]; other site 358681002165 putative catalytic motif [active] 358681002166 substrate binding site [chemical binding]; other site 358681002167 PAS fold; Region: PAS_4; pfam08448 358681002168 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 358681002169 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 358681002170 metal binding site [ion binding]; metal-binding site 358681002171 active site 358681002172 I-site; other site 358681002173 Phosphatidylserine decarboxylase; Region: PS_Dcarbxylase; cl03656 358681002174 aspartyl/glutamyl-tRNA amidotransferase subunit C; Reviewed; Region: gatC; PRK00034 358681002175 Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154 358681002176 aspartyl/glutamyl-tRNA amidotransferase subunit A; Reviewed; Region: gatA; PRK00012 358681002177 aspartyl/glutamyl-tRNA amidotransferase subunit B; Validated; Region: gatB; PRK05477 358681002178 GatB/GatE catalytic domain; Region: GatB_N; pfam02934 358681002179 GatB domain; Region: GatB_Yqey; smart00845 358681002180 DNA-directed RNA polymerase specialized sigma subunit, sigma24 homolog [Transcription]; Region: RpoE; COG1595 358681002181 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 358681002182 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 358681002183 DNA binding residues [nucleotide binding] 358681002184 A predicted NlpC/p60-like peptidase; Region: BtrH; pfam14399 358681002185 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 358681002186 EamA-like transporter family; Region: EamA; cl17759 358681002187 EamA-like transporter family; Region: EamA; pfam00892 358681002188 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 358681002189 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 358681002190 DNA-binding site [nucleotide binding]; DNA binding site 358681002191 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 358681002192 pyridoxal 5'-phosphate binding site [chemical binding]; other site 358681002193 homodimer interface [polypeptide binding]; other site 358681002194 catalytic residue [active] 358681002195 ABC-type Na+ transport system, ATPase component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatA; COG4555 358681002196 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 358681002197 Walker A/P-loop; other site 358681002198 ATP binding site [chemical binding]; other site 358681002199 Q-loop/lid; other site 358681002200 ABC transporter signature motif; other site 358681002201 Walker B; other site 358681002202 D-loop; other site 358681002203 H-loop/switch region; other site 358681002204 ABC-type Na+ efflux pump, permease component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatB; COG1668 358681002205 ABC-2 family transporter protein; Region: ABC2_membrane_2; cl17866 358681002206 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 358681002207 EamA-like transporter family; Region: EamA; pfam00892 358681002208 EamA-like transporter family; Region: EamA; pfam00892 358681002209 ROK family protein (putative glucokinase); Region: ROK_glcA_fam; TIGR00744 358681002210 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 358681002211 putative lipid kinase; Reviewed; Region: PRK13337 358681002212 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; pfam00781 358681002213 Predicted RNA-binding protein, contains TRAM domain [General function prediction only]; Region: COG3269 358681002214 23S rRNA (uracil-5-)-methyltransferase RumA; Region: rumA; TIGR00479 358681002215 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 358681002216 S-adenosylmethionine binding site [chemical binding]; other site 358681002217 phiLC3 phage and phage-related integrases, site-specific recombinases, DNA breaking-rejoining enzymes, C-terminal catalytic domain. This CD includes various bacterial (mainly gram positive) and phage integrases, including those similar to Lactococcus...; Region: INT_phiLC3_C; cd01189 358681002218 Int/Topo IB signature motif; other site 358681002219 type I restriction system adenine methylase (hsdM); Region: hsdM; TIGR00497 358681002220 HsdM N-terminal domain; Region: HsdM_N; pfam12161 358681002221 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 358681002222 S-adenosylmethionine binding site [chemical binding]; other site 358681002223 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 358681002224 Restriction endonuclease S subunits [Defense mechanisms]; Region: HsdS; COG0732 358681002225 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 358681002226 AAA domain; Region: AAA_13; pfam13166 358681002227 Type I site-specific restriction-modification system, R (restriction) subunit and related helicases [Defense mechanisms]; Region: COG0610 358681002228 Type I restriction enzyme R protein N terminus (HSDR_N); Region: HSDR_N; pfam04313 358681002229 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 358681002230 ATP binding site [chemical binding]; other site 358681002231 putative Mg++ binding site [ion binding]; other site 358681002232 Integrase core domain; Region: rve; pfam00665 358681002233 Integrase core domain; Region: rve_3; cl15866 358681002234 SMI1 / KNR4 family (SUKH-1); Region: SMI1_KNR4; cl01747 358681002235 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 358681002236 active site 358681002237 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 358681002238 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 358681002239 non-specific DNA binding site [nucleotide binding]; other site 358681002240 salt bridge; other site 358681002241 sequence-specific DNA binding site [nucleotide binding]; other site 358681002242 Protein of unknown function (DUF1311); Region: DUF1311; cl01530 358681002243 TPR repeat; Region: TPR_11; pfam13414 358681002244 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 358681002245 binding surface 358681002246 TPR motif; other site 358681002247 TPR repeat; Region: TPR_11; pfam13414 358681002248 TPR repeat; Region: TPR_11; pfam13414 358681002249 TPR repeat; Region: TPR_11; pfam13414 358681002250 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 358681002251 binding surface 358681002252 TPR motif; other site 358681002253 Tetratricopeptide repeat; Region: TPR_16; pfam13432 358681002254 Thiol-activated cytolysin; Region: Thiol_cytolysin; pfam01289 358681002255 Cell wall hydrolyses involved in spore germination [Cell envelope biogenesis, outer membrane]; Region: SleB; COG3773 358681002256 Cell Wall Hydrolase; Region: Hydrolase_2; pfam07486 358681002257 Glycosyl transferases, related to UDP-glucuronosyltransferase [Carbohydrate transport and metabolism / Signal transduction mechanisms]; Region: COG1819 358681002258 A4GalT_like proteins catalyze the addition of galactose or glucose residues to the lipooligosaccharide (LOS) or lipopolysaccharide (LPS) of the bacterial cell surface; Region: GT8_A4GalT_like; cd04194 358681002259 Glycosyl transferase family 8; Region: Glyco_transf_8; pfam01501 358681002260 Ligand binding site; other site 358681002261 metal-binding site 358681002262 This family includes the Gtfs, a group of homologous glycosyltransferases involved in the final stages of the biosynthesis of antibiotics vancomycin and related chloroeremomycin. Gtfs transfer sugar moieties from an activated NDP-sugar donor to the...; Region: GT1_Gtf_like; cd03784 358681002263 glycosyltransferase, MGT family; Region: MGT; TIGR01426 358681002264 active site 358681002265 TDP-binding site; other site 358681002266 acceptor substrate-binding pocket; other site 358681002267 homodimer interface [polypeptide binding]; other site 358681002268 HEAT repeats; Region: HEAT_2; pfam13646 358681002269 SMI1 / KNR4 family (SUKH-1); Region: SMI1_KNR4; pfam09346 358681002270 Esterase-like activity of phytase; Region: Phytase-like; pfam13449 358681002271 Tryptophan synthase beta superfamily (fold type II); this family of pyridoxal phosphate (PLP)-dependent enzymes catalyzes beta-replacement and beta-elimination reactions. This CD corresponds to aminocyclopropane-1-carboxylate deaminase (ACCD), tryptophan...; Region: Trp-synth-beta_II; cl00342 358681002272 Na+ dependent nucleoside transporter C-terminus; Region: Nucleos_tra2_C; pfam07662 358681002273 CAAX protease self-immunity; Region: Abi; pfam02517 358681002274 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 358681002275 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 358681002276 Predicted Fe-S oxidoreductases [General function prediction only]; Region: COG0535 358681002277 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 358681002278 FeS/SAM binding site; other site 358681002279 Domain of unknown function (DUF4008); Region: DUF4008; pfam13186 358681002280 Copper amine oxidase N-terminal domain; Region: Cu_amine_oxidN1; pfam07833 358681002281 H+ Antiporter protein; Region: 2A0121; TIGR00900 358681002282 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 358681002283 putative substrate translocation pore; other site 358681002284 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 358681002285 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 358681002286 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 358681002287 S-adenosylmethionine binding site [chemical binding]; other site 358681002288 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 358681002289 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 358681002290 active site 358681002291 phosphorylation site [posttranslational modification] 358681002292 intermolecular recognition site; other site 358681002293 dimerization interface [polypeptide binding]; other site 358681002294 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 358681002295 DNA binding residues [nucleotide binding] 358681002296 dimerization interface [polypeptide binding]; other site 358681002297 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 358681002298 Histidine kinase; Region: HisKA_3; pfam07730 358681002299 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518 358681002300 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 358681002301 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 358681002302 Walker A/P-loop; other site 358681002303 ATP binding site [chemical binding]; other site 358681002304 Q-loop/lid; other site 358681002305 ABC transporter signature motif; other site 358681002306 Walker B; other site 358681002307 D-loop; other site 358681002308 H-loop/switch region; other site 358681002309 ABC-type Na+ efflux pump, permease component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatB; COG1668 358681002310 ABC-2 family transporter protein; Region: ABC2_membrane_3; pfam12698 358681002311 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 358681002312 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 358681002313 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 358681002314 Glycosyl hydrolases family 2, sugar binding domain; Region: Glyco_hydro_2_N; pfam02837 358681002315 Predicted acyltransferases [Lipid metabolism]; Region: COG1835 358681002316 7TM diverse intracellular signalling; Region: 7TMR-DISM_7TM; pfam07695 358681002317 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 358681002318 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 358681002319 dimer interface [polypeptide binding]; other site 358681002320 phosphorylation site [posttranslational modification] 358681002321 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 358681002322 ATP binding site [chemical binding]; other site 358681002323 Mg2+ binding site [ion binding]; other site 358681002324 G-X-G motif; other site 358681002325 Response regulator receiver domain; Region: Response_reg; pfam00072 358681002326 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 358681002327 active site 358681002328 phosphorylation site [posttranslational modification] 358681002329 intermolecular recognition site; other site 358681002330 dimerization interface [polypeptide binding]; other site 358681002331 Predicted signal transduction protein with a C-terminal ATPase domain [Signal transduction mechanisms]; Region: COG2972 358681002332 Histidine kinase; Region: His_kinase; pfam06580 358681002333 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 358681002334 ATP binding site [chemical binding]; other site 358681002335 Mg2+ binding site [ion binding]; other site 358681002336 G-X-G motif; other site 358681002337 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 358681002338 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 358681002339 Bacterial transcriptional repressor; Region: TetR_C_6; pfam13977 358681002340 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 358681002341 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 358681002342 Coenzyme A binding pocket [chemical binding]; other site 358681002343 Putative zinc-finger; Region: zf-HC2; pfam13490 358681002344 Domain of unknown function (DUF4179); Region: DUF4179; pfam13786 358681002345 RNA polymerase sigma factor RpoE; Provisional; Region: PRK09652 358681002346 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 358681002347 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 358681002348 DNA binding residues [nucleotide binding] 358681002349 SMI1 / KNR4 family; Region: SMI1_KNR4; smart00860 358681002350 Predicted phosphohydrolases [General function prediction only]; Region: Icc; COG1409 358681002351 Calcineurin-like phosphoesterase superfamily domain; Region: Metallophos_2; pfam12850 358681002352 active site 358681002353 metal binding site [ion binding]; metal-binding site 358681002354 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 358681002355 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 358681002356 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 358681002357 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 358681002358 Major Facilitator Superfamily; Region: MFS_1; pfam07690 358681002359 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 358681002360 putative substrate translocation pore; other site 358681002361 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 358681002362 MarR family; Region: MarR; pfam01047 358681002363 MarR family; Region: MarR_2; cl17246 358681002364 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 358681002365 salt bridge; other site 358681002366 non-specific DNA binding site [nucleotide binding]; other site 358681002367 sequence-specific DNA binding site [nucleotide binding]; other site 358681002368 RT_G2_intron: Reverse transcriptases (RTs) with group II intron origin. RT transcribes DNA using RNA as template. Proteins in this subfamily are found in bacterial and mitochondrial group II introns. Their most probable ancestor was a retrotransposable...; Region: RT_G2_intron; cd01651 358681002369 Reverse transcriptase (RNA-dependent DNA polymerase); Region: RVT_1; pfam00078 358681002370 putative active site [active] 358681002371 putative NTP binding site [chemical binding]; other site 358681002372 putative nucleic acid binding site [nucleotide binding]; other site 358681002373 Group II intron, maturase-specific domain; Region: GIIM; pfam08388 358681002374 Spo0E like sporulation regulatory protein; Region: SpoOE-like; pfam09388 358681002375 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 358681002376 Transposase; Region: HTH_Tnp_1; cl17663 358681002377 Predicted metal-dependent hydrolase with the TIM-barrel fold [General function prediction only]; Region: COG1574 358681002378 YtcJ_like metal dependent amidohydrolases. YtcJ is a Bacillus subtilis ORF of unknown function. The Arabidopsis homolog LAF3 has been identified as a factor required for photochrome A signalling; Region: YtcJ_like; cd01300 358681002379 active site 358681002380 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 358681002381 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 358681002382 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 358681002383 Coenzyme A binding pocket [chemical binding]; other site 358681002384 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 358681002385 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 358681002386 active site 358681002387 phosphorylation site [posttranslational modification] 358681002388 intermolecular recognition site; other site 358681002389 dimerization interface [polypeptide binding]; other site 358681002390 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 358681002391 DNA binding residues [nucleotide binding] 358681002392 dimerization interface [polypeptide binding]; other site 358681002393 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 358681002394 Histidine kinase; Region: HisKA_3; pfam07730 358681002395 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 358681002396 ATP binding site [chemical binding]; other site 358681002397 Mg2+ binding site [ion binding]; other site 358681002398 G-X-G motif; other site 358681002399 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 358681002400 putative DNA binding site [nucleotide binding]; other site 358681002401 putative Zn2+ binding site [ion binding]; other site 358681002402 Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841 358681002403 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 358681002404 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 358681002405 HlyD family secretion protein; Region: HlyD_3; pfam13437 358681002406 Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726 358681002407 Catalytic NodB homology domain of rhizobial NodB-like proteins; Region: CE4_NodB_like_6s_7s; cd10917 358681002408 NodB motif; other site 358681002409 active site 358681002410 catalytic site [active] 358681002411 metal binding site [ion binding]; metal-binding site 358681002412 Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726 358681002413 Catalytic NodB homology domain of rhizobial NodB-like proteins; Region: CE4_NodB_like_6s_7s; cd10917 358681002414 NodB motif; other site 358681002415 active site 358681002416 catalytic site [active] 358681002417 metal binding site [ion binding]; metal-binding site 358681002418 ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614 358681002419 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 358681002420 intersubunit interface [polypeptide binding]; other site 358681002421 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 358681002422 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 358681002423 Walker A/P-loop; other site 358681002424 ATP binding site [chemical binding]; other site 358681002425 Q-loop/lid; other site 358681002426 ABC transporter signature motif; other site 358681002427 Walker B; other site 358681002428 D-loop; other site 358681002429 H-loop/switch region; other site 358681002430 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 358681002431 FtsX-like permease family; Region: FtsX; pfam02687 358681002432 ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614 358681002433 Fe3+-siderophore binding domain FhuD. These proteins have been shown to function as initial receptors in ABC transport of Fe3+-siderophores in many eubacterial species. They belong to the TroA-like superfamily of helical backbone metal receptor proteins...; Region: FhuD; cd01146 358681002434 siderophore binding site; other site 358681002435 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 358681002436 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 358681002437 ABC-ATPase subunit interface; other site 358681002438 dimer interface [polypeptide binding]; other site 358681002439 putative PBP binding regions; other site 358681002440 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 358681002441 ABC-ATPase subunit interface; other site 358681002442 dimer interface [polypeptide binding]; other site 358681002443 putative PBP binding regions; other site 358681002444 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 358681002445 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 358681002446 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 358681002447 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 358681002448 Periplasmic binding protein; Region: Peripla_BP_2; pfam01497 358681002449 intersubunit interface [polypeptide binding]; other site 358681002450 Fe3+-siderophore binding domain FhuD. These proteins have been shown to function as initial receptors in ABC transport of Fe3+-siderophores in many eubacterial species. They belong to the TroA-like superfamily of helical backbone metal receptor proteins...; Region: FhuD; cd01146 358681002451 Periplasmic binding protein; Region: Peripla_BP_2; pfam01497 358681002452 siderophore binding site; other site 358681002453 Fatty acid desaturase [Lipid metabolism]; Region: DesA; COG3239 358681002454 The Delta12 Fatty Acid Desaturase (Delta12-FADS)-like CD includes the integral-membrane enzymes, delta-12 acyl-lipid desaturases, oleate 12-hydroxylases, omega3 and omega6 fatty acid desaturases, and other related proteins, found in a wide range of...; Region: Delta12-FADS-like; cd03507 358681002455 putative di-iron ligands [ion binding]; other site 358681002456 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 358681002457 Histidine kinase; Region: HisKA_3; pfam07730 358681002458 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 358681002459 ATP binding site [chemical binding]; other site 358681002460 Mg2+ binding site [ion binding]; other site 358681002461 G-X-G motif; other site 358681002462 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 358681002463 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 358681002464 active site 358681002465 phosphorylation site [posttranslational modification] 358681002466 intermolecular recognition site; other site 358681002467 dimerization interface [polypeptide binding]; other site 358681002468 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 358681002469 DNA binding residues [nucleotide binding] 358681002470 dimerization interface [polypeptide binding]; other site 358681002471 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 358681002472 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 358681002473 non-specific DNA binding site [nucleotide binding]; other site 358681002474 salt bridge; other site 358681002475 sequence-specific DNA binding site [nucleotide binding]; other site 358681002476 Cupin domain; Region: Cupin_2; pfam07883 358681002477 Cyanate permease [Inorganic ion transport and metabolism]; Region: CynX; COG2807 358681002478 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 358681002479 putative substrate translocation pore; other site 358681002480 Spore coat protein [Cell envelope biogenesis, outer membrane]; Region: COG5577 358681002481 Glutathione-dependent formaldehyde dehydrogenase related proteins, child 1; Region: FDH_like_1; cd08283 358681002482 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 358681002483 NAD binding site [chemical binding]; other site 358681002484 catalytic Zn binding site [ion binding]; other site 358681002485 structural Zn binding site [ion binding]; other site 358681002486 Spore coat protein [Cell envelope biogenesis, outer membrane]; Region: COG5577 358681002487 Protein of unknown function (DUF805); Region: DUF805; pfam05656 358681002488 S-adenosylmethionine decarboxylase; Provisional; Region: PRK05462 358681002489 S-layer homology domain; Region: SLH; pfam00395 358681002490 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 358681002491 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 358681002492 non-specific DNA binding site [nucleotide binding]; other site 358681002493 salt bridge; other site 358681002494 sequence-specific DNA binding site [nucleotide binding]; other site 358681002495 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 358681002496 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 358681002497 active site 358681002498 phosphorylation site [posttranslational modification] 358681002499 intermolecular recognition site; other site 358681002500 dimerization interface [polypeptide binding]; other site 358681002501 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 358681002502 DNA binding site [nucleotide binding] 358681002503 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 358681002504 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 358681002505 dimerization interface [polypeptide binding]; other site 358681002506 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 358681002507 dimer interface [polypeptide binding]; other site 358681002508 phosphorylation site [posttranslational modification] 358681002509 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 358681002510 ATP binding site [chemical binding]; other site 358681002511 Mg2+ binding site [ion binding]; other site 358681002512 G-X-G motif; other site 358681002513 Predicted amidohydrolase [General function prediction only]; Region: COG0388 358681002514 Uncharacterized subgroup of the nitrilase superfamily (putative class 13 nitrilases); Region: nitrilase_3; cd07581 358681002515 putative active site [active] 358681002516 catalytic triad [active] 358681002517 putative dimer interface [polypeptide binding]; other site 358681002518 RT_G2_intron: Reverse transcriptases (RTs) with group II intron origin. RT transcribes DNA using RNA as template. Proteins in this subfamily are found in bacterial and mitochondrial group II introns. Their most probable ancestor was a retrotransposable...; Region: RT_G2_intron; cd01651 358681002519 Reverse transcriptase (RNA-dependent DNA polymerase); Region: RVT_1; pfam00078 358681002520 putative active site [active] 358681002521 putative NTP binding site [chemical binding]; other site 358681002522 putative nucleic acid binding site [nucleotide binding]; other site 358681002523 Group II intron, maturase-specific domain; Region: GIIM; pfam08388 358681002524 Predicted Na+/dicarboxylate symporter [General function prediction only]; Region: COG1823 358681002525 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 358681002526 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 358681002527 The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504 358681002528 peptide binding site [polypeptide binding]; other site 358681002529 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675 358681002530 Helix-turn-helix domain; Region: HTH_OrfB_IS605; pfam12323 358681002531 Probable transposase; Region: OrfB_IS605; pfam01385 358681002532 transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766 358681002533 Putative transposase DNA-binding domain; Region: OrfB_Zn_ribbon; pfam07282 358681002534 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 358681002535 triphenylmethane reductase (TMR)-like proteins, NMRa-like, atypical (a) SDRs; Region: TMR_SDR_a; cd05269 358681002536 NADP binding site [chemical binding]; other site 358681002537 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 358681002538 M20 Peptidases Aminoacyclase-1 indole-3-acetic-L-aspartic acid hydrolase from bacteria and archaea; Region: M20_Acy1_IAAspH_bact; cd05665 358681002539 putative metal binding site [ion binding]; other site 358681002540 dimer interface [polypeptide binding]; other site 358681002541 M20 Peptidase Aminoacylase 1-like protein 2 aminobenzoyl-glutamate utilization protein B subfamily; Region: M20_Acy1L2_AbgB; cd05673 358681002542 amidohydrolase; Region: amidohydrolases; TIGR01891 358681002543 putative metal binding site [ion binding]; other site 358681002544 Ferrochelatase; Region: Ferrochelatase; pfam00762 358681002545 Class II Chelatase: a family of ATP-independent monomeric or homodimeric enzymes that catalyze the insertion of metal into protoporphyrin rings. This family includes protoporphyrin IX ferrochelatase (HemH), sirohydrochlorin ferrochelatase (SirB) and the...; Region: Chelatase_Class_II; cl02784 358681002546 active site 358681002547 Class II Chelatase: a family of ATP-independent monomeric or homodimeric enzymes that catalyze the insertion of metal into protoporphyrin rings. This family includes protoporphyrin IX ferrochelatase (HemH), sirohydrochlorin ferrochelatase (SirB) and the...; Region: Chelatase_Class_II; cl02784 358681002548 active site 358681002549 Methyltransferase domain; Region: Methyltransf_31; pfam13847 358681002550 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 358681002551 S-adenosylmethionine binding site [chemical binding]; other site 358681002552 Predicted membrane protein [Function unknown]; Region: COG2364 358681002553 Transcriptional regulators [Transcription]; Region: PurR; COG1609 358681002554 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 358681002555 DNA binding site [nucleotide binding] 358681002556 domain linker motif; other site 358681002557 Ligand-binding domain of a novel transcription factor implicated in catabolite repression in Bacillus and Clostridium species; Region: PBP1_CcpB_like; cd06286 358681002558 putative dimerization interface [polypeptide binding]; other site 358681002559 putative ligand binding site [chemical binding]; other site 358681002560 right oriC-binding transcriptional activator; Provisional; Region: PRK15121 358681002561 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 358681002562 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 358681002563 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3708 358681002564 putative acetyltransferase; Provisional; Region: PRK03624 358681002565 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 358681002566 Coenzyme A binding pocket [chemical binding]; other site 358681002567 PAS fold; Region: PAS; pfam00989 358681002568 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 358681002569 putative active site [active] 358681002570 heme pocket [chemical binding]; other site 358681002571 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 358681002572 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 358681002573 Walker A motif; other site 358681002574 ATP binding site [chemical binding]; other site 358681002575 Walker B motif; other site 358681002576 arginine finger; other site 358681002577 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 358681002578 M20 Peptidase Aminoacylase 1 amhX_like subfamily; Region: M20_Acy1_amhX_like; cd08018 358681002579 metal binding site [ion binding]; metal-binding site 358681002580 putative dimer interface [polypeptide binding]; other site 358681002581 Predicted membrane protein [Function unknown]; Region: COG1288 358681002582 C4-dicarboxylate anaerobic carrier; Region: DcuC; pfam03606 358681002583 Methyltransferase domain; Region: Methyltransf_23; pfam13489 358681002584 Methyltransferase domain; Region: Methyltransf_12; pfam08242 358681002585 Trk-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: TrkG; COG0168 358681002586 potassium uptake protein, TrkH family; Region: 2a38; TIGR00933 358681002587 putative multidrug transporter membrane\ATP-binding components; Provisional; Region: PRK10789 358681002588 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 358681002589 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 358681002590 Walker A/P-loop; other site 358681002591 ATP binding site [chemical binding]; other site 358681002592 Q-loop/lid; other site 358681002593 ABC transporter signature motif; other site 358681002594 Walker B; other site 358681002595 D-loop; other site 358681002596 H-loop/switch region; other site 358681002597 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 358681002598 ABC-type transport system involved in Fe-S cluster assembly, permease and ATPase components [Posttranslational modification, protein turnover, chaperones]; Region: ATM1; COG5265 358681002599 ATP-binding cassette domain of glucan transporter and related proteins, subfamily C; Region: ABCC_Glucan_exporter_like; cd03254 358681002600 Walker A/P-loop; other site 358681002601 ATP binding site [chemical binding]; other site 358681002602 Q-loop/lid; other site 358681002603 ABC transporter signature motif; other site 358681002604 Walker B; other site 358681002605 D-loop; other site 358681002606 H-loop/switch region; other site 358681002607 Domain of unknown function (DUF1904); Region: DUF1904; pfam08921 358681002608 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 358681002609 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 358681002610 Domain of unknown function (DUF4367); Region: DUF4367; pfam14285 358681002611 EamA-like transporter family; Region: EamA; pfam00892 358681002612 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 358681002613 EamA-like transporter family; Region: EamA; pfam00892 358681002614 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 358681002615 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 358681002616 DNA-binding site [nucleotide binding]; DNA binding site 358681002617 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 358681002618 pyridoxal 5'-phosphate binding site [chemical binding]; other site 358681002619 homodimer interface [polypeptide binding]; other site 358681002620 catalytic residue [active] 358681002621 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 358681002622 DNA-binding site [nucleotide binding]; DNA binding site 358681002623 RNA-binding motif; other site 358681002624 16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187 358681002625 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 358681002626 RNA binding surface [nucleotide binding]; other site 358681002627 Pseudouridine synthase, Escherichia coli RluF like; Region: PseudoU_synth_RluF; cd02554 358681002628 probable active site [active] 358681002629 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2258 358681002630 MOSC domain; Region: MOSC; pfam03473 358681002631 3-alpha domain; Region: 3-alpha; pfam03475 358681002632 nicotinate phosphoribosyltransferase; Validated; Region: PRK09243 358681002633 Nicotinate phosphoribosyltransferase (NAPRTase), subgroup A. Nicotinate phosphoribosyltransferase catalyses the formation of NAMN and PPi from 5-phosphoribosy -1-pyrophosphate (PRPP) and nicotinic acid, this is the first, and also rate limiting, reaction...; Region: NAPRTase_A; cd01570 358681002634 active site 358681002635 Glutamate dehydrogenase/leucine dehydrogenase [Amino acid transport and metabolism]; Region: GdhA; COG0334 358681002636 Glu/Leu/Phe/Val dehydrogenase, dimerisation domain; Region: ELFV_dehydrog_N; pfam02812 358681002637 NAD(P) binding domain of glutamate dehydrogenase, subgroup 1; Region: NAD_bind_1_Glu_DH; cd01076 358681002638 NAD(P) binding site [chemical binding]; other site 358681002639 Homoserine O-succinyltransferase; Region: HTS; pfam04204 358681002640 Type 1 glutamine amidotransferase (GATase1)-like domain found in homoserine trans-succinylase (HTS); Region: GATase1_HTS; cd03131 358681002641 proposed active site lysine [active] 358681002642 conserved cys residue [active] 358681002643 Transcriptional regulator [Transcription]; Region: LysR; COG0583 358681002644 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 358681002645 The C-terminal substrate binding domain of LysR-like transcriptional regulator CidR, contains the type 2 periplasmic binding fold; Region: PBP2_CidR; cd08438 358681002646 putative dimerization interface [polypeptide binding]; other site 358681002647 Putative effector of murein hydrolase LrgA [General function prediction only]; Region: COG1380 358681002648 Putative effector of murein hydrolase [Cell envelope biogenesis, outer membrane]; Region: LrgB; COG1346 358681002649 putative acetyltransferase; Provisional; Region: PRK03624 358681002650 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 358681002651 Coenzyme A binding pocket [chemical binding]; other site 358681002652 EamA-like transporter family; Region: EamA; pfam00892 358681002653 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 358681002654 EamA-like transporter family; Region: EamA; pfam00892 358681002655 transglutaminase; Provisional; Region: tgl; PRK03187 358681002656 N-methyltryptophan oxidase; Provisional; Region: solA; PRK11259 358681002657 hydroxyglutarate oxidase; Provisional; Region: PRK11728 358681002658 Four helix bundle sensory module for signal transduction; Region: 4HB_MCP_1; pfam12729 358681002659 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 358681002660 dimerization interface [polypeptide binding]; other site 358681002661 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 358681002662 dimer interface [polypeptide binding]; other site 358681002663 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 358681002664 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 358681002665 dimer interface [polypeptide binding]; other site 358681002666 putative CheW interface [polypeptide binding]; other site 358681002667 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 358681002668 Ankyrin repeat; Region: Ank; pfam00023 358681002669 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 358681002670 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 358681002671 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 358681002672 Conserved protein/domain typically associated with flavoprotein oxygenases, DIM6/NTAB family [General function prediction only]; Region: COG1853 358681002673 Cro/C1-type HTH DNA-binding domain; Region: HTH_26; pfam13443 358681002674 Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487 358681002675 active site 358681002676 catalytic residues [active] 358681002677 metal binding site [ion binding]; metal-binding site 358681002678 Predicted divalent heavy-metal cations transporter [Inorganic ion transport and metabolism]; Region: COG0428 358681002679 flagellar motor protein MotA; Validated; Region: PRK08124 358681002680 MotA/TolQ/ExbB proton channel family; Region: MotA_ExbB; cl00568 358681002681 flagellar motor protein MotB; Reviewed; Region: motB; PRK07734 358681002682 Membrane MotB of proton-channel complex MotA/MotB; Region: MotB_plug; pfam13677 358681002683 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 358681002684 ligand binding site [chemical binding]; other site 358681002685 Predicted transcriptional regulators [Transcription]; Region: COG1733 358681002686 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 358681002687 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 358681002688 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 358681002689 Protein-tyrosine-phosphatase [Signal transduction mechanisms]; Region: Wzb; COG0394 358681002690 Low molecular weight phosphatase family; Region: LMWPc; cd00115 358681002691 active site 358681002692 sensory histidine kinase AtoS; Provisional; Region: PRK11360 358681002693 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 358681002694 putative active site [active] 358681002695 heme pocket [chemical binding]; other site 358681002696 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 358681002697 dimer interface [polypeptide binding]; other site 358681002698 phosphorylation site [posttranslational modification] 358681002699 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 358681002700 ATP binding site [chemical binding]; other site 358681002701 Mg2+ binding site [ion binding]; other site 358681002702 G-X-G motif; other site 358681002703 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204 358681002704 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 358681002705 active site 358681002706 phosphorylation site [posttranslational modification] 358681002707 intermolecular recognition site; other site 358681002708 dimerization interface [polypeptide binding]; other site 358681002709 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 358681002710 Walker A motif; other site 358681002711 ATP binding site [chemical binding]; other site 358681002712 Walker B motif; other site 358681002713 arginine finger; other site 358681002714 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 358681002715 Short chain fatty acids transporter [Lipid metabolism]; Region: AtoE; COG2031 358681002716 Membrane transporters of cations and cationic drugs [Inorganic ion transport and metabolism]; Region: EmrE; COG2076 358681002717 Membrane transporters of cations and cationic drugs [Inorganic ion transport and metabolism]; Region: EmrE; COG2076 358681002718 Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053 358681002719 Cation efflux family; Region: Cation_efflux; pfam01545 358681002720 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 358681002721 Domain of unknown function DUF21; Region: DUF21; pfam01595 358681002722 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 358681002723 Transporter associated domain; Region: CorC_HlyC; smart01091 358681002724 Uncharacterized homologs of Site-2 protease (S2P), zinc metalloproteases (MEROPS family M50) which cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of the...; Region: S2P-M50_like_2; cd06160 358681002725 Peptidase family M50; Region: Peptidase_M50; pfam02163 358681002726 active site 358681002727 putative substrate binding region [chemical binding]; other site 358681002728 Iron-sulphur cluster biosynthesis; Region: Fe-S_biosyn; cl00400 358681002729 Protein of unknown function (DUF3905); Region: DUF3905; pfam13045 358681002730 Protein of unknown function (DUF3886); Region: DUF3886; pfam13025 358681002731 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 358681002732 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 358681002733 FtsX-like permease family; Region: FtsX; pfam02687 358681002734 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 358681002735 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 358681002736 Walker A/P-loop; other site 358681002737 ATP binding site [chemical binding]; other site 358681002738 Q-loop/lid; other site 358681002739 ABC transporter signature motif; other site 358681002740 Walker B; other site 358681002741 D-loop; other site 358681002742 H-loop/switch region; other site 358681002743 HlyD family secretion protein; Region: HlyD_2; pfam12700 358681002744 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 358681002745 E3 interaction surface; other site 358681002746 lipoyl attachment site [posttranslational modification]; other site 358681002747 HlyD family secretion protein; Region: HlyD_3; pfam13437 358681002748 glucose-6-phosphate isomerase; Provisional; Region: pgi; PRK14097 358681002749 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the first SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_1; cd05015 358681002750 active site 358681002751 dimer interface [polypeptide binding]; other site 358681002752 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the second SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_2; cd05016 358681002753 dimer interface [polypeptide binding]; other site 358681002754 active site 358681002755 Helix-turn-helix domain; Region: HTH_17; cl17695 358681002756 glycine oxidase ThiO; Region: thiamin_ThiO; TIGR02352 358681002757 hydroxyglutarate oxidase; Provisional; Region: PRK11728 358681002758 YugN-like family; Region: YugN; pfam08868 358681002759 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_21; cd04680 358681002760 nudix motif; other site 358681002761 NAD kinase [Coenzyme metabolism]; Region: nadF; cl01255 358681002762 ATP-NAD kinase; Region: NAD_kinase; pfam01513 358681002763 MOSC N-terminal beta barrel domain; Region: MOSC_N; pfam03476 358681002764 Uncharacterized Fe-S protein [General function prediction only]; Region: COG3217 358681002765 MOSC domain; Region: MOSC; pfam03473 358681002766 This CD, composed mainly of bacterial single-domain proteins, includes the Thermus thermophilus (Tt) YbaK-like protein, a homolog of the trans-acting Escherichia coli YbaK Cys-tRNA(Pro) deacylase and the Agrobacterium tumefaciens ProX Ala-tRNA(Pro)...; Region: ProX_deacylase; cd04333 358681002767 putative deacylase active site [active] 358681002768 Major Facilitator Superfamily; Region: MFS_1; pfam07690 358681002769 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 358681002770 putative substrate translocation pore; other site 358681002771 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 358681002772 Sortase and related acyltransferases [Cell envelope biogenesis, outer membrane]; Region: COG1247 358681002773 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 358681002774 Coenzyme A binding pocket [chemical binding]; other site 358681002775 hypothetical protein; Provisional; Region: PRK07740 358681002776 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 358681002777 active site 358681002778 substrate binding site [chemical binding]; other site 358681002779 catalytic site [active] 358681002780 Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401 358681002781 metal binding triad; other site 358681002782 Putative nucleotidyltransferase substrate binding domain; Region: DUF294_C; pfam10335 358681002783 Ammonia permease [Inorganic ion transport and metabolism]; Region: AmtB; COG0004 358681002784 H+ Antiporter protein; Region: 2A0121; TIGR00900 358681002785 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 358681002786 putative substrate translocation pore; other site 358681002787 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 358681002788 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 358681002789 putative substrate translocation pore; other site 358681002790 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 358681002791 dimerization interface [polypeptide binding]; other site 358681002792 putative DNA binding site [nucleotide binding]; other site 358681002793 putative Zn2+ binding site [ion binding]; other site 358681002794 TOPRIM_ RNase M5_like: The topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain found in Ribonuclease M5: (RNase M5) and other small primase-like proteins from bacteria and archaea. RNase M5 catalyzes the maturation of 5S rRNA in low...; Region: TOPRIM_RNase_M5_like; cd01027 358681002795 putative active site [active] 358681002796 putative metal binding site [ion binding]; other site 358681002797 undecaprenyl pyrophosphate phosphatase; Reviewed; Region: PRK00281 358681002798 Predicted RNA-bindining protein (contains S1 and HTH domains) [General function prediction only]; Region: COG2996 358681002799 S1 domain; Region: S1_2; pfam13509 358681002800 Ribosomal protein S1-like RNA-binding domain; Region: S1; smart00316 358681002801 TRAP transporter, 4TM/12TM fusion protein; Region: TRAP_fused; TIGR02123 358681002802 DctM-like transporters; Region: DctM; pfam06808 358681002803 Domain of unknown function (DUF1850); Region: DUF1850; pfam08905 358681002804 TRAP-type uncharacterized transport system, periplasmic component [General function prediction only]; Region: Imp; COG2358 358681002805 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 358681002806 substrate binding pocket [chemical binding]; other site 358681002807 membrane-bound complex binding site; other site 358681002808 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 358681002809 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 358681002810 ATP binding site [chemical binding]; other site 358681002811 Mg2+ binding site [ion binding]; other site 358681002812 G-X-G motif; other site 358681002813 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 358681002814 Response regulator receiver domain; Region: Response_reg; pfam00072 358681002815 active site 358681002816 phosphorylation site [posttranslational modification] 358681002817 intermolecular recognition site; other site 358681002818 dimerization interface [polypeptide binding]; other site 358681002819 YcbB domain; Region: YcbB; pfam08664 358681002820 Protein of unknown function (DUF2600); Region: DUF2600; pfam10776 358681002821 PilZ domain; Region: PilZ; pfam07238 358681002822 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 358681002823 putative substrate translocation pore; other site 358681002824 H+ Antiporter protein; Region: 2A0121; TIGR00900 358681002825 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 358681002826 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 358681002827 DNA binding site [nucleotide binding] 358681002828 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 358681002829 PAS domain; Region: PAS_9; pfam13426 358681002830 putative active site [active] 358681002831 heme pocket [chemical binding]; other site 358681002832 psp operon transcriptional activator PspF; Region: phageshock_pspF; TIGR02974 358681002833 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 358681002834 Walker A motif; other site 358681002835 ATP binding site [chemical binding]; other site 358681002836 Walker B motif; other site 358681002837 arginine finger; other site 358681002838 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 358681002839 Proline dehydrogenase [Amino acid transport and metabolism]; Region: PutA; COG0506 358681002840 8-oxoguanine DNA glycosylase, N-terminal domain; Region: OGG_N; pfam07934 358681002841 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 358681002842 endonuclease III; Region: ENDO3c; smart00478 358681002843 minor groove reading motif; other site 358681002844 helix-hairpin-helix signature motif; other site 358681002845 substrate binding pocket [chemical binding]; other site 358681002846 active site 358681002847 Branched-chain amino acid transport protein; Region: Branch_AA_trans; pfam05525 358681002848 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 358681002849 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 358681002850 active site 358681002851 phosphorylation site [posttranslational modification] 358681002852 intermolecular recognition site; other site 358681002853 dimerization interface [polypeptide binding]; other site 358681002854 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 358681002855 DNA binding site [nucleotide binding] 358681002856 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 358681002857 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 358681002858 dimerization interface [polypeptide binding]; other site 358681002859 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 358681002860 dimer interface [polypeptide binding]; other site 358681002861 phosphorylation site [posttranslational modification] 358681002862 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 358681002863 ATP binding site [chemical binding]; other site 358681002864 Mg2+ binding site [ion binding]; other site 358681002865 G-X-G motif; other site 358681002866 Microcin C7 self-immunity protein determines resistance to exogenous microcin C7; Region: Peptidase_S66_mccF_like; cd07062 358681002867 putative dimer interface [polypeptide binding]; other site 358681002868 catalytic triad [active] 358681002869 EamA-like transporter family; Region: EamA; pfam00892 358681002870 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 358681002871 EamA-like transporter family; Region: EamA; pfam00892 358681002872 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 358681002873 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 358681002874 Coenzyme A binding pocket [chemical binding]; other site 358681002875 Protein of unknown function (DUF1572); Region: DUF1572; pfam07609 358681002876 DinB superfamily; Region: DinB_2; pfam12867 358681002877 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 358681002878 active site 358681002879 Septum formation initiator; Region: DivIC; cl17659 358681002880 haloacid dehalogenase superfamily, subfamily IA, variant 1 with third motif having Dx(3-4)D or Dx(3-4)E; Region: HAD-SF-IA-v1; TIGR01549 358681002881 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 358681002882 motif II; other site 358681002883 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 358681002884 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 358681002885 Walker A/P-loop; other site 358681002886 ATP binding site [chemical binding]; other site 358681002887 Q-loop/lid; other site 358681002888 ABC transporter signature motif; other site 358681002889 Walker B; other site 358681002890 D-loop; other site 358681002891 H-loop/switch region; other site 358681002892 ABC-2 family transporter protein; Region: ABC2_membrane_2; cl17866 358681002893 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 358681002894 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 358681002895 active site 358681002896 phosphorylation site [posttranslational modification] 358681002897 intermolecular recognition site; other site 358681002898 dimerization interface [polypeptide binding]; other site 358681002899 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 358681002900 DNA binding site [nucleotide binding] 358681002901 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 358681002902 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 358681002903 dimer interface [polypeptide binding]; other site 358681002904 phosphorylation site [posttranslational modification] 358681002905 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 358681002906 ATP binding site [chemical binding]; other site 358681002907 Mg2+ binding site [ion binding]; other site 358681002908 G-X-G motif; other site 358681002909 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 358681002910 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 358681002911 Coenzyme A binding pocket [chemical binding]; other site 358681002912 Uncharacterized conserved protein [Function unknown]; Region: COG1284 358681002913 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 358681002914 Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; pfam10035 358681002915 Putative hydrophobic ligand-binding SRPBCC domain of Micromonospora echinospora CalC, human Aha1, and related proteins; Region: SRPBCC_CalC_Aha1-like; cd07814 358681002916 putative hydrophobic ligand binding site [chemical binding]; other site 358681002917 Protein of unknown function DUF2625; Region: DUF2625; cl08177 358681002918 ethanolamine utilization protein EutH; Provisional; Region: PRK15086 358681002919 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 358681002920 DNA-binding site [nucleotide binding]; DNA binding site 358681002921 RNA-binding motif; other site 358681002922 Nitroreductase-like family 4. A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes, nitrofurans and...; Region: Nitroreductase_4; cd02140 358681002923 dimer interface [polypeptide binding]; other site 358681002924 FMN binding site [chemical binding]; other site 358681002925 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 358681002926 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_16; cd07263 358681002927 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 358681002928 S-adenosylmethionine binding site [chemical binding]; other site 358681002929 hypothetical protein; Provisional; Region: PRK08236 358681002930 Predicted periplasmic solute-binding protein [General function prediction only]; Region: COG2107 358681002931 Copper/zinc superoxide dismutase (SOD). superoxide dismutases catalyse the conversion of superoxide radicals to molecular oxygen. Three evolutionarily distinct families of SODs are known, of which the copper/zinc-binding family is one. Defects in the...; Region: Cu-Zn_Superoxide_Dismutase; cd00305 358681002932 E-class dimer interface [polypeptide binding]; other site 358681002933 P-class dimer interface [polypeptide binding]; other site 358681002934 active site 358681002935 Cu2+ binding site [ion binding]; other site 358681002936 Zn2+ binding site [ion binding]; other site 358681002937 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 358681002938 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 358681002939 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 358681002940 active site 358681002941 phosphorylation site [posttranslational modification] 358681002942 intermolecular recognition site; other site 358681002943 dimerization interface [polypeptide binding]; other site 358681002944 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 358681002945 DNA binding site [nucleotide binding] 358681002946 heavy metal sensor kinase; Region: cztS_silS_copS; TIGR01386 358681002947 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 358681002948 dimer interface [polypeptide binding]; other site 358681002949 phosphorylation site [posttranslational modification] 358681002950 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 358681002951 ATP binding site [chemical binding]; other site 358681002952 Mg2+ binding site [ion binding]; other site 358681002953 G-X-G motif; other site 358681002954 Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416 358681002955 ABC-type Fe3+ transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: AfuA; COG1840 358681002956 ABC-type Fe3+ transport system, permease component [Inorganic ion transport and metabolism]; Region: ThiP; COG1178 358681002957 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 358681002958 dimer interface [polypeptide binding]; other site 358681002959 conserved gate region; other site 358681002960 ABC-ATPase subunit interface; other site 358681002961 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 358681002962 dimer interface [polypeptide binding]; other site 358681002963 conserved gate region; other site 358681002964 putative PBP binding loops; other site 358681002965 ABC-ATPase subunit interface; other site 358681002966 ATP-binding cassette domain of the carbohydrate and solute transporters-like; Region: ABC_Carb_Solutes_like; cd03259 358681002967 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 358681002968 Walker A/P-loop; other site 358681002969 ATP binding site [chemical binding]; other site 358681002970 Q-loop/lid; other site 358681002971 ABC transporter signature motif; other site 358681002972 Walker B; other site 358681002973 D-loop; other site 358681002974 H-loop/switch region; other site 358681002975 Predicted dithiol-disulfide isomerase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: FrnE; COG2761 358681002976 DsbA family, FrnE subfamily; FrnE is a DsbA-like protein containing a CXXC motif. It is presumed to be a thiol oxidoreductase involved in polyketide biosynthesis, specifically in the production of the aromatic antibiotics frenolicin and nanaomycins; Region: DsbA_FrnE; cd03024 358681002977 catalytic residues [active] 358681002978 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 358681002979 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 358681002980 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 358681002981 DNA binding residues [nucleotide binding] 358681002982 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 358681002983 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 358681002984 Predicted transcriptional regulator [Transcription]; Region: COG2378 358681002985 HTH domain; Region: HTH_11; pfam08279 358681002986 WYL domain; Region: WYL; pfam13280 358681002987 RelA- and SpoT-like ppGpp Synthetases and Hydrolases, catalytic domain; Region: Rel-Spo_like; cl11966 358681002988 metal binding triad [ion binding]; metal-binding site 358681002989 Domain of unknown function (DUF4111); Region: DUF4111; pfam13427 358681002990 Histone acetyltransferase HPA2 and related acetyltransferases [Transcription / General function prediction only]; Region: WecD; COG0454 358681002991 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 358681002992 Coenzyme A binding pocket [chemical binding]; other site 358681002993 Suppressor of fused protein (SUFU); Region: SUFU; pfam05076 358681002994 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 358681002995 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 358681002996 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 358681002997 DNA binding residues [nucleotide binding] 358681002998 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 358681002999 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 358681003000 TatD like proteins; E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310 358681003001 active site 358681003002 Domain of Unknown Function (DUF1259); Region: DUF1529; pfam07485 358681003003 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 358681003004 FtsX-like permease family; Region: FtsX; pfam02687 358681003005 Ubiquitin-like proteins; Region: UBQ; cl00155 358681003006 charged pocket; other site 358681003007 hydrophobic patch; other site 358681003008 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 358681003009 FtsX-like permease family; Region: FtsX; pfam02687 358681003010 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 358681003011 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 358681003012 Walker A/P-loop; other site 358681003013 ATP binding site [chemical binding]; other site 358681003014 Q-loop/lid; other site 358681003015 ABC transporter signature motif; other site 358681003016 Walker B; other site 358681003017 D-loop; other site 358681003018 H-loop/switch region; other site 358681003019 DNA alkylation repair enzyme; Region: DNA_alkylation; pfam08713 358681003020 A new structural DNA glycosylase; Region: AlkD_like; cd06561 358681003021 active site 358681003022 Predicted transcriptional regulators [Transcription]; Region: COG1378 358681003023 Sugar-specific transcriptional regulator TrmB; Region: TrmB; pfam01978 358681003024 Middle phospholipase D-like domain of the transcriptional regulator TrmB and similar proteins; Region: PLDc_like_TrmB_middle; cd09124 358681003025 C-terminal domain interface [polypeptide binding]; other site 358681003026 sugar binding site [chemical binding]; other site 358681003027 Predicted branched-chain amino acid permease (azaleucine resistance) [Amino acid transport and metabolism]; Region: AzlC; COG1296 358681003028 Branched-chain amino acid transport protein (AzlD); Region: AzlD; pfam05437 358681003029 Putative intracellular protease/amidase [General function prediction only]; Region: ThiJ; COG0693 358681003030 Type 1 glutamine amidotransferase (GATase1)-like domain found in a subgroup of proteins similar to PfpI from Pyrococcus furiosus; Region: GATase1_PfpI_3; cd03140 358681003031 conserved cys residue [active] 358681003032 Transposase IS200 like; Region: Y1_Tnp; pfam01797 358681003033 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675 358681003034 Helix-turn-helix domain; Region: HTH_OrfB_IS605; pfam12323 358681003035 Probable transposase; Region: OrfB_IS605; pfam01385 358681003036 transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766 358681003037 Protein of unknown function (DUF2992); Region: DUF2992; pfam11208 358681003038 Restriction endonuclease; Region: Mrr_cat; pfam04471 358681003039 TRAM domain; Region: TRAM; pfam01938 358681003040 SAM-dependent methyltransferases related to tRNA (uracil-5-)-methyltransferase [Translation, ribosomal structure and biogenesis]; Region: TrmA; COG2265 358681003041 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 358681003042 S-adenosylmethionine binding site [chemical binding]; other site 358681003043 threonine dehydratase; Validated; Region: PRK08639 358681003044 Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562 358681003045 tetramer interface [polypeptide binding]; other site 358681003046 pyridoxal 5'-phosphate binding site [chemical binding]; other site 358681003047 catalytic residue [active] 358681003048 Second of two tandem C-terminal ACT domains of threonine dehydratase I (ThrD-I; L-threonine hydrolyase); Region: ACT_ThrD-I_2; cd04907 358681003049 putative Ile/Val binding site [chemical binding]; other site 358681003050 YhfH-like protein; Region: YhfH; pfam14149 358681003051 BioY family; Region: BioY; pfam02632 358681003052 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 358681003053 Cytochrome P450; Region: p450; pfam00067 358681003054 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 358681003055 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 358681003056 dimerization interface [polypeptide binding]; other site 358681003057 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 358681003058 dimer interface [polypeptide binding]; other site 358681003059 phosphorylation site [posttranslational modification] 358681003060 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 358681003061 ATP binding site [chemical binding]; other site 358681003062 Mg2+ binding site [ion binding]; other site 358681003063 G-X-G motif; other site 358681003064 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 358681003065 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 358681003066 active site 358681003067 phosphorylation site [posttranslational modification] 358681003068 intermolecular recognition site; other site 358681003069 dimerization interface [polypeptide binding]; other site 358681003070 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 358681003071 DNA binding site [nucleotide binding] 358681003072 NlpC/P60 family; Region: NLPC_P60; pfam00877 358681003073 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 358681003074 Phage shock protein A (IM30), suppresses sigma54-dependent transcription [Transcription / Signal transduction mechanisms]; Region: PspA; COG1842 358681003075 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 358681003076 S-adenosylmethionine binding site [chemical binding]; other site 358681003077 Cell wall-active antibiotics response protein (DUF2154); Region: DUF2154; pfam09922 358681003078 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 358681003079 HAMP domain; Region: HAMP; pfam00672 358681003080 Histidine kinase; Region: HisKA_3; pfam07730 358681003081 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 358681003082 ATP binding site [chemical binding]; other site 358681003083 Mg2+ binding site [ion binding]; other site 358681003084 G-X-G motif; other site 358681003085 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 358681003086 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 358681003087 active site 358681003088 phosphorylation site [posttranslational modification] 358681003089 intermolecular recognition site; other site 358681003090 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 358681003091 DNA binding residues [nucleotide binding] 358681003092 dimerization interface [polypeptide binding]; other site 358681003093 bis(5'-nucleosyl)-tetraphosphatase PrpE; Provisional; Region: PRK13625 358681003094 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 358681003095 active site 358681003096 metal binding site [ion binding]; metal-binding site 358681003097 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 358681003098 active site 358681003099 metal binding site [ion binding]; metal-binding site 358681003100 Uncharacterized protein family (UPF0154); Region: UPF0154; cl01536 358681003101 DNA-binding transcriptional regulator CynR; Provisional; Region: PRK11242 358681003102 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 358681003103 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 358681003104 dimerization interface [polypeptide binding]; other site 358681003105 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 358681003106 Major Facilitator Superfamily; Region: MFS_1; pfam07690 358681003107 putative substrate translocation pore; other site 358681003108 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 358681003109 2-isopropylmalate synthase; Validated; Region: PRK00915 358681003110 2-isopropylmalate synthase (IPMS), N-terminal catalytic TIM barrel domain; Region: DRE_TIM_IPMS; cd07940 358681003111 active site 358681003112 catalytic residues [active] 358681003113 metal binding site [ion binding]; metal-binding site 358681003114 LeuA allosteric (dimerisation) domain; Region: LeuA_dimer; smart00917 358681003115 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 358681003116 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 358681003117 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 358681003118 DNA binding residues [nucleotide binding] 358681003119 hypothetical protein; Provisional; Region: PRK10621 358681003120 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 358681003121 Superoxide dismutase [Inorganic ion transport and metabolism]; Region: SodA; COG0605 358681003122 Iron/manganese superoxide dismutases, alpha-hairpin domain; Region: Sod_Fe_N; pfam00081 358681003123 Iron/manganese superoxide dismutases, C-terminal domain; Region: Sod_Fe_C; pfam02777 358681003124 The Class III extradiol dioxygenase, 4,5-DOPA Dioxygenase, catalyzes the incorporation of both atoms of molecular oxygen into 4,5-dihydroxy-phenylalanine; Region: 45_DOPA_Dioxygenase; cd07363 358681003125 Catalytic LigB subunit of aromatic ring-opening dioxygenase; Region: LigB; pfam02900 358681003126 putative active site [active] 358681003127 metal binding site [ion binding]; metal-binding site 358681003128 RNA polymerase sigma-70 factor, TIGR02957 family; Region: SigX4 358681003129 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 358681003130 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 358681003131 DNA binding residues [nucleotide binding] 358681003132 Carboxymuconolactone decarboxylase family; Region: CMD; pfam02627 358681003133 Uncharacterized conserved protein [Function unknown]; Region: COG2128 358681003134 Predicted flavin-nucleotide-binding protein [General function prediction only]; Region: COG3467 358681003135 Predicted membrane-bound metal-dependent hydrolases [General function prediction only]; Region: COG1988 358681003136 Antibiotic biosynthesis monooxygenase; Region: ABM; cl10022 358681003137 A/G-specific DNA glycosylase [DNA replication, recombination, and repair]; Region: MutY; COG1194 358681003138 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 358681003139 minor groove reading motif; other site 358681003140 helix-hairpin-helix signature motif; other site 358681003141 substrate binding pocket [chemical binding]; other site 358681003142 active site 358681003143 Iron-sulfur binding domain of endonuclease III; Region: EndIII_4Fe-2S; pfam10576 358681003144 DNA glycosylase (MutY in bacteria and hMYH in humans) is responsible for repairing misread A*oxoG residues to C*G by removing the inappropriately paired adenine base from the DNA backbone. It belongs to the Nudix hydrolase superfamily and is important...; Region: DNA_Glycosylase_C; cd03431 358681003145 DNA binding and oxoG recognition site [nucleotide binding] 358681003146 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 358681003147 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 358681003148 active site 358681003149 motif I; other site 358681003150 motif II; other site 358681003151 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 358681003152 ligand binding domain of Tar- and Tsr-related chemoreceptors; Region: Tar_Tsr_LBD; cl00144 358681003153 Cache domain; Region: Cache_1; pfam02743 358681003154 TIM21; Region: TIM21; pfam08294 358681003155 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 358681003156 dimerization interface [polypeptide binding]; other site 358681003157 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 358681003158 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 358681003159 dimer interface [polypeptide binding]; other site 358681003160 putative CheW interface [polypeptide binding]; other site 358681003161 enoyl-(acyl carrier protein) reductase; Provisional; Region: PRK08063 358681003162 1-cyclohexenylcarbonyl_coenzyme A_reductase (ChcA)_like, classical (c) SDRs; Region: ChcA_like_SDR_c; cd05359 358681003163 putative NAD(P) binding site [chemical binding]; other site 358681003164 active site 358681003165 putative acetyltransferase; Provisional; Region: PRK03624 358681003166 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 358681003167 Coenzyme A binding pocket [chemical binding]; other site 358681003168 hypothetical protein; Provisional; Region: PRK13662 358681003169 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 358681003170 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 358681003171 ATP-binding cassette domain of the bacterial lipid flippase and related proteins, subfamily C; Region: ABCC_MsbA; cd03251 358681003172 Walker A/P-loop; other site 358681003173 ATP binding site [chemical binding]; other site 358681003174 Q-loop/lid; other site 358681003175 ABC transporter signature motif; other site 358681003176 Walker B; other site 358681003177 D-loop; other site 358681003178 H-loop/switch region; other site 358681003179 drug efflux system protein MdtG; Provisional; Region: PRK09874 358681003180 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 358681003181 putative substrate translocation pore; other site 358681003182 H+ Antiporter protein; Region: 2A0121; TIGR00900 358681003183 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 358681003184 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 358681003185 Methylamine utilisation protein MauE; Region: MauE; pfam07291 358681003186 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 358681003187 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 358681003188 Walker A/P-loop; other site 358681003189 ATP binding site [chemical binding]; other site 358681003190 Q-loop/lid; other site 358681003191 ABC transporter signature motif; other site 358681003192 Walker B; other site 358681003193 D-loop; other site 358681003194 H-loop/switch region; other site 358681003195 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 358681003196 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 358681003197 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084 358681003198 Cupin domain; Region: Cupin_2; pfam07883 358681003199 Pyrroline-5-carboxylate reductase [Amino acid transport and metabolism]; Region: ProC; COG0345 358681003200 NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; cl17232 358681003201 Predicted Zn-dependent protease [General function prediction only]; Region: COG2738 358681003202 glutamate-1-semialdehyde aminotransferase; Provisional; Region: PRK12389 358681003203 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 358681003204 inhibitor-cofactor binding pocket; inhibition site 358681003205 pyridoxal 5'-phosphate binding site [chemical binding]; other site 358681003206 catalytic residue [active] 358681003207 Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cl00120 358681003208 active site 358681003209 ABC-type uncharacterized transport system, ATPase component [General function prediction only]; Region: COG4586 358681003210 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 358681003211 Walker A/P-loop; other site 358681003212 ATP binding site [chemical binding]; other site 358681003213 Q-loop/lid; other site 358681003214 ABC transporter signature motif; other site 358681003215 Walker B; other site 358681003216 D-loop; other site 358681003217 H-loop/switch region; other site 358681003218 ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG4587 358681003219 ABC-2 family transporter protein; Region: ABC2_membrane_6; cl01496 358681003220 ABC-2 family transporter protein; Region: ABC2_membrane_6; cl01496 358681003221 ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG4587 358681003222 Predicted membrane protein [Function unknown]; Region: COG3601 358681003223 Protein of unknown function (DUF3816); Region: DUF3816; pfam12822 358681003224 prolyl-tRNA synthetase; Provisional; Region: PRK08661 358681003225 Prolyl-tRNA synthetase (ProRS) class II core catalytic domain. ProRS is a homodimer. It is responsible for the attachment of proline to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ProRS_core_arch_euk; cd00778 358681003226 dimer interface [polypeptide binding]; other site 358681003227 motif 1; other site 358681003228 active site 358681003229 motif 2; other site 358681003230 motif 3; other site 358681003231 ProRS Prolyl-anticodon binding domain, long version found predominantly in eukaryotes and archaea. ProRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in...; Region: ProRS_anticodon_zinc; cd00862 358681003232 anticodon binding site; other site 358681003233 zinc-binding site [ion binding]; other site 358681003234 pyrophosphatase PpaX; Provisional; Region: PRK13288 358681003235 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 358681003236 motif II; other site 358681003237 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 358681003238 dimerization interface [polypeptide binding]; other site 358681003239 putative DNA binding site [nucleotide binding]; other site 358681003240 putative Zn2+ binding site [ion binding]; other site 358681003241 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cl17220 358681003242 Peroxiredoxin (PRX) family, Bacterioferritin comigratory protein (BCP) subfamily; composed of thioredoxin-dependent thiol peroxidases, widely expressed in pathogenic bacteria, that protect cells against toxicity from reactive oxygen species by reducing...; Region: PRX_BCP; cd03017 358681003243 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 358681003244 catalytic triad [active] 358681003245 M42 Peptidase, Endoglucanase-like subfamily; Region: M42_glucanase_like; cd05657 358681003246 Cellulase M and related proteins [Carbohydrate transport and metabolism]; Region: FrvX; COG1363 358681003247 putative oligomer interface [polypeptide binding]; other site 358681003248 putative active site [active] 358681003249 metal binding site [ion binding]; metal-binding site 358681003250 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 358681003251 S-adenosylmethionine binding site [chemical binding]; other site 358681003252 Cobalamin adenosyltransferase; Region: Cob_adeno_trans; pfam01923 358681003253 Predicted nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG0702 358681003254 NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, subunit 9, 39 kDa, (NDUFA9) -like, atypical (a) SDRs; Region: NDUFA9_like_SDR_a; cd05271 358681003255 putative NAD(P) binding site [chemical binding]; other site 358681003256 active site 358681003257 Predicted EndoIII-related endonuclease [DNA replication, recombination, and repair]; Region: Nth; COG0177 358681003258 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 358681003259 minor groove reading motif; other site 358681003260 helix-hairpin-helix signature motif; other site 358681003261 substrate binding pocket [chemical binding]; other site 358681003262 active site 358681003263 ferric uptake regulator; Provisional; Region: fur; PRK09462 358681003264 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 358681003265 metal binding site 2 [ion binding]; metal-binding site 358681003266 putative DNA binding helix; other site 358681003267 metal binding site 1 [ion binding]; metal-binding site 358681003268 dimer interface [polypeptide binding]; other site 358681003269 structural Zn2+ binding site [ion binding]; other site 358681003270 Copper amine oxidase N-terminal domain; Region: Cu_amine_oxidN1; pfam07833 358681003271 Bacterial SH3 domain; Region: SH3_3; pfam08239 358681003272 Cortical fragment-lytic enzyme (CFLE) is a peptidoglycan hydrolase involved in bacterial endospore germination. CFLE is expressed as an inactive preprotein (called SleB) in the forespore compartment of sporulating cells. SleB translocates across the...; Region: GH18_CFLE_spore_hydrolase; cd02874 358681003273 active site 358681003274 hypothetical protein; Provisional; Region: PRK02935 358681003275 putative uracil/xanthine transporter; Provisional; Region: PRK11412 358681003276 Solo B3/4 domain (OB-fold DNA/RNA-binding) of Phe-aaRS-beta [General function prediction only]; Region: COG3382 358681003277 B3/4 domain; Region: B3_4; pfam03483 358681003278 RNase HI family found mainly in prokaryotes; Region: RNase_HI_prokaryote_like; cd09278 358681003279 RNA/DNA hybrid binding site [nucleotide binding]; other site 358681003280 active site 358681003281 epoxyqueuosine reductase; Region: TIGR00276 358681003282 Domain of unknown function (DUF1730); Region: DUF1730; pfam08331 358681003283 4Fe-4S binding domain; Region: Fer4; pfam00037 358681003284 HEAT repeats; Region: HEAT_2; pfam13646 358681003285 E-Z type HEAT repeats; Region: EZ_HEAT; smart00567 358681003286 6-O-methylguanine DNA methyltransferase, ribonuclease-like domain; Region: Methyltransf_1N; pfam02870 358681003287 methylated-DNA--protein-cysteine methyltransferase; Provisional; Region: PRK00901 358681003288 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 358681003289 DNA binding site [nucleotide binding] 358681003290 active site 358681003291 Putative amidase domain; Region: Amidase_6; pfam12671 358681003292 Predicted rRNA methylase (SpoU class) [Translation, ribosomal structure and biogenesis]; Region: CspR; COG0219 358681003293 Predicted hydrolase (HAD superfamily) [General function prediction only]; Region: COG1011 358681003294 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 358681003295 motif II; other site 358681003296 Putative Ser protein kinase [Signal transduction mechanisms]; Region: PrkA; COG2766 358681003297 PrkA serine protein kinase C-terminal domain; Region: PrkA; pfam06798 358681003298 sporulation protein YhbH; Region: spore_yhbH; TIGR02877 358681003299 yiaA/B two helix domain; Region: YiaAB; pfam05360 358681003300 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 358681003301 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 358681003302 homoserine O-acetyltransferase; Provisional; Region: metX; cl17114 358681003303 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 358681003304 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 358681003305 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 358681003306 dimer interface [polypeptide binding]; other site 358681003307 putative CheW interface [polypeptide binding]; other site 358681003308 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 358681003309 Coenzyme A binding pocket [chemical binding]; other site 358681003310 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 358681003311 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 358681003312 substrate binding pocket [chemical binding]; other site 358681003313 membrane-bound complex binding site; other site 358681003314 hinge residues; other site 358681003315 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 358681003316 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 358681003317 dimer interface [polypeptide binding]; other site 358681003318 conserved gate region; other site 358681003319 putative PBP binding loops; other site 358681003320 ABC-ATPase subunit interface; other site 358681003321 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 358681003322 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 358681003323 Walker A/P-loop; other site 358681003324 ATP binding site [chemical binding]; other site 358681003325 Q-loop/lid; other site 358681003326 ABC transporter signature motif; other site 358681003327 Walker B; other site 358681003328 D-loop; other site 358681003329 H-loop/switch region; other site 358681003330 KTSC domain; Region: KTSC; pfam13619 358681003331 Predicted transcriptional regulators [Transcription]; Region: COG1695 358681003332 Transcriptional regulator PadR-like family; Region: PadR; cl17335 358681003333 Glycosyl hydrolases related to GH101 family; Region: GHL; pfam11308 358681003334 Transcriptional regulator [Transcription]; Region: LysR; COG0583 358681003335 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 358681003336 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 358681003337 dimerization interface [polypeptide binding]; other site 358681003338 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK05565 358681003339 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 358681003340 NAD(P) binding site [chemical binding]; other site 358681003341 active site 358681003342 Spore germination protein gerPA/gerPF; Region: gerPA; pfam10676 358681003343 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 358681003344 FMN-dependent dehydrogenase; Region: FMN_dh; pfam01070 358681003345 phosphate binding site [ion binding]; other site 358681003346 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 358681003347 FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202 358681003348 putative active site [active] 358681003349 heme pocket [chemical binding]; other site 358681003350 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 358681003351 putative active site [active] 358681003352 heme pocket [chemical binding]; other site 358681003353 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 358681003354 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 358681003355 metal binding site [ion binding]; metal-binding site 358681003356 active site 358681003357 I-site; other site 358681003358 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 358681003359 EamA-like transporter family; Region: EamA; pfam00892 358681003360 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 358681003361 EamA-like transporter family; Region: EamA; pfam00892 358681003362 nicotinic acid mononucleotide adenylyltransferase; Provisional; Region: nadD; PRK00071 358681003363 Nicotinamide/nicotinate mononucleotide adenylyltransferase; Region: NMNAT; cd02165 358681003364 active site 358681003365 (T/H)XGH motif; other site 358681003366 Isochorismatase family; Region: Isochorismatase; pfam00857 358681003367 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cd00431 358681003368 catalytic triad [active] 358681003369 conserved cis-peptide bond; other site 358681003370 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cd02883 358681003371 nudix motif; other site 358681003372 Uncharacterized conserved protein [General function prediction only]; Region: COG4111 358681003373 YceI-like domain; Region: YceI; pfam04264 358681003374 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 358681003375 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 358681003376 active site 358681003377 phosphorylation site [posttranslational modification] 358681003378 intermolecular recognition site; other site 358681003379 dimerization interface [polypeptide binding]; other site 358681003380 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 358681003381 DNA binding site [nucleotide binding] 358681003382 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 358681003383 dimerization interface [polypeptide binding]; other site 358681003384 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 358681003385 dimer interface [polypeptide binding]; other site 358681003386 phosphorylation site [posttranslational modification] 358681003387 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 358681003388 ATP binding site [chemical binding]; other site 358681003389 Mg2+ binding site [ion binding]; other site 358681003390 G-X-G motif; other site 358681003391 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 358681003392 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cl17220 358681003393 AsnC family; Region: AsnC_trans_reg; pfam01037 358681003394 hypothetical protein; Validated; Region: PRK07682 358681003395 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 358681003396 pyridoxal 5'-phosphate binding site [chemical binding]; other site 358681003397 homodimer interface [polypeptide binding]; other site 358681003398 catalytic residue [active] 358681003399 Aminoglycoside/hydroxyurea antibiotic resistance kinase; Region: APH_6_hur; cl17810 358681003400 Phosphotransferase enzyme family; Region: APH; pfam01636 358681003401 Outer membrane efflux protein; Region: OEP; pfam02321 358681003402 lysine transporter; Provisional; Region: PRK10836 358681003403 DinB superfamily; Region: DinB_2; pfam12867 358681003404 CGNR zinc finger; Region: zf-CGNR; pfam11706 358681003405 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483 358681003406 IMPase, inositol monophosphatase and related domains. A family of Mg++ dependent phosphatases, inhibited by lithium, many of which may act on inositol monophosphate substrate. They dephosphorylate inositol phosphate to generate inositol, which may be...; Region: IMPase; cd01639 358681003407 active site 358681003408 dimerization interface [polypeptide binding]; other site 358681003409 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 358681003410 Lipase. Lipases are esterases that can hydrolyze long-chain acyl-triglycerides into di- and monoglycerides, glycerol, and free fatty acids at a water/lipid interface. A typical feature of lipases is "interfacial activation", the process of...; Region: Lipase; cl14883 358681003411 nucleophilic elbow; other site 358681003412 catalytic triad; other site 358681003413 Domain of unknown function (DUF955); Region: DUF955; pfam06114 358681003414 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 358681003415 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 358681003416 non-specific DNA binding site [nucleotide binding]; other site 358681003417 salt bridge; other site 358681003418 sequence-specific DNA binding site [nucleotide binding]; other site 358681003419 Protein of unknown function (DUF2762); Region: DUF2762; pfam10960 358681003420 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270 358681003421 Phosphotransferase enzyme family; Region: APH; pfam01636 358681003422 active site 358681003423 ATP binding site [chemical binding]; other site 358681003424 A predicted NlpC/p60-like peptidase; Region: BtrH; pfam14399 358681003425 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 358681003426 Sodium:dicarboxylate symporter family; Region: SDF; pfam00375 358681003427 Ferritin-like domain; Region: Ferritin; pfam00210 358681003428 DPS protein, ferritin-like diiron-binding domain; Region: DPS; cd01043 358681003429 dimerization interface [polypeptide binding]; other site 358681003430 DPS ferroxidase diiron center [ion binding]; other site 358681003431 ion pore; other site 358681003432 MobA catalyzes the formation of molybdopterin guanine dinucleotide; Region: MobA; cd02503 358681003433 molybdopterin-guanine dinucleotide biosynthesis protein MobA; Reviewed; Region: mobA; PRK00317 358681003434 GTP binding site; other site 358681003435 formate dehydrogenase accessory protein; Reviewed; Region: PRK00724 358681003436 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 358681003437 Major Facilitator Superfamily; Region: MFS_1; pfam07690 358681003438 putative substrate translocation pore; other site 358681003439 Uncharacterized conserved protein [Function unknown]; Region: COG5609 358681003440 oxidoreductase alpha (molybdopterin) subunit; Region: Fdhalpha-like; TIGR01701 358681003441 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 358681003442 molybdopterin cofactor binding site; other site 358681003443 Molybdopterin-Binding, C-terminal (MopB_CT) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum-...; Region: MopB_CT; cl09929 358681003444 molybdopterin cofactor binding site; other site 358681003445 Molybdopterin biosynthesis enzyme [Coenzyme metabolism]; Region: MoeA; COG0303 358681003446 MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoeA; cd00887 358681003447 dimer interface [polypeptide binding]; other site 358681003448 putative functional site; other site 358681003449 putative MPT binding site; other site 358681003450 Molybdenum is an essential trace element in the form of molybdenum cofactor (Moco) which is associated with the metabolism of nitrogen, carbon and sulfur by redox active enzymes. In E. coli, the synthesis of Moco involves genes from several loci: moa; Region: MobB; cd03116 358681003451 Walker A motif; other site 358681003452 Uncharacterized protein conserved in bacteria (DUF2199); Region: DUF2199; cl02048 358681003453 Predicted flavin-nucleotide-binding protein [General function prediction only]; Region: COG3467 358681003454 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 358681003455 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 358681003456 DNA-binding site [nucleotide binding]; DNA binding site 358681003457 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 358681003458 pyridoxal 5'-phosphate binding site [chemical binding]; other site 358681003459 homodimer interface [polypeptide binding]; other site 358681003460 catalytic residue [active] 358681003461 bifunctional nitric oxide dioxygenase/dihydropteridine reductase 2; Provisional; Region: PRK13289 358681003462 Globins are heme proteins, which bind and transport oxygen. This family summarizes a diverse set of homologous protein domains, including: (1) tetrameric vertebrate hemoglobins, which are the major protein component of erythrocytes and transport oxygen...; Region: globin; cd01040 358681003463 heme-binding site [chemical binding]; other site 358681003464 FAD_NAD(P)H binding domain of flavohemoglobin. Flavohemoglobins have a globin domain containing a B-type heme fused with a ferredoxin reductase-like FAD/NAD-binding domain. Flavohemoglobins detoxify nitric oxide (NO) via an NO dioxygenase reaction. The...; Region: flavohem_like_fad_nad_binding; cd06184 358681003465 FAD binding pocket [chemical binding]; other site 358681003466 FAD binding motif [chemical binding]; other site 358681003467 phosphate binding motif [ion binding]; other site 358681003468 beta-alpha-beta structure motif; other site 358681003469 NAD binding pocket [chemical binding]; other site 358681003470 Heme binding pocket [chemical binding]; other site 358681003471 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 358681003472 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 358681003473 ligand binding site [chemical binding]; other site 358681003474 flexible hinge region; other site 358681003475 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cl17320 358681003476 Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220 358681003477 Beta-lactamase superfamily domain; Region: Lactamase_B_2; pfam12706 358681003478 oligoendopeptidase, pepF/M3 family; Region: M3_fam_3; TIGR02290 358681003479 Peptidase family M3B Oligopeptidase F (PepF); Region: M3B_PepF_2; cd09607 358681003480 active site 358681003481 Zn binding site [ion binding]; other site 358681003482 Predicted membrane-bound metal-dependent hydrolases [General function prediction only]; Region: COG1988 358681003483 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 358681003484 dimerization interface [polypeptide binding]; other site 358681003485 putative DNA binding site [nucleotide binding]; other site 358681003486 putative Zn2+ binding site [ion binding]; other site 358681003487 putative transporter; Provisional; Region: PRK10054 358681003488 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 358681003489 putative substrate translocation pore; other site 358681003490 Predicted methyltransferases [General function prediction only]; Region: COG1568 358681003491 Superfamily I DNA and RNA helicases [General function prediction only]; Region: COG3973 358681003492 Family description; Region: UvrD_C_2; pfam13538 358681003493 Domain of unknown function (DUF4179); Region: DUF4179; pfam13786 358681003494 DNA-directed RNA polymerase specialized sigma subunit, sigma24 homolog [Transcription]; Region: RpoE; COG1595 358681003495 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 358681003496 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 358681003497 DNA binding residues [nucleotide binding] 358681003498 Uncharacterized small membrane protein [Function unknown]; Region: COG2363 358681003499 Probable transposase; Region: OrfB_IS605; pfam01385 358681003500 transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766 358681003501 Putative transposase DNA-binding domain; Region: OrfB_Zn_ribbon; pfam07282 358681003502 Transposase IS200 like; Region: Y1_Tnp; pfam01797 358681003503 NIPSNAP; Region: NIPSNAP; pfam07978 358681003504 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 358681003505 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 358681003506 active site 358681003507 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 358681003508 phage transcriptional regulator, ArpU family; Region: phage_arpU; TIGR01637 358681003509 ParB-like nuclease domain; Region: ParBc; pfam02195 358681003510 Stage 0 sporulation protein J (antagonist of Soj) containing ParB-like nuclease domain [Transcription]; Region: Spo0J; COG1475 358681003511 Uncharacterized conserved protein [Function unknown]; Region: SpoVR; COG2719 358681003512 SpoVR like protein; Region: SpoVR; pfam04293 358681003513 3-oxoacyl-(acyl-carrier-protein) reductase; Region: 3oxo_ACP_reduc; TIGR01830 358681003514 classical (c) SDRs; Region: SDR_c; cd05233 358681003515 NAD(P) binding site [chemical binding]; other site 358681003516 active site 358681003517 short chain dehydrogenase; Provisional; Region: PRK07326 358681003518 classical (c) SDRs; Region: SDR_c; cd05233 358681003519 NAD(P) binding site [chemical binding]; other site 358681003520 active site 358681003521 3-hydroxyacyl-CoA dehydrogenase [Lipid metabolism]; Region: FadB; COG1250 358681003522 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 358681003523 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 358681003524 ligand binding domain of Tar- and Tsr-related chemoreceptors; Region: Tar_Tsr_LBD; cl00144 358681003525 Cache domain; Region: Cache_1; pfam02743 358681003526 Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840 358681003527 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 358681003528 dimerization interface [polypeptide binding]; other site 358681003529 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 358681003530 dimer interface [polypeptide binding]; other site 358681003531 putative CheW interface [polypeptide binding]; other site 358681003532 Pleckstrin homology-like domain; Region: PH-like; cl17171 358681003533 integral membrane protein, YjbE family; Region: R_switched_YjbE; TIGR03717 358681003534 Transcriptional regulator [Transcription]; Region: LysR; COG0583 358681003535 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 358681003536 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 358681003537 dimerization interface [polypeptide binding]; other site 358681003538 membrane protein AbrB duplication; Region: Gneg_AbrB_dup; TIGR03082 358681003539 Putative ammonia monooxygenase [General function prediction only]; Region: AbrB; COG3180 358681003540 membrane protein AbrB duplication; Region: Gneg_AbrB_dup; TIGR03082 358681003541 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3181 358681003542 Tripartite tricarboxylate transporter TctB family; Region: TctB; pfam07331 358681003543 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3333 358681003544 Methyltransferase domain; Region: Methyltransf_31; pfam13847 358681003545 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 358681003546 S-adenosylmethionine binding site [chemical binding]; other site 358681003547 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 358681003548 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 358681003549 putative DNA binding site [nucleotide binding]; other site 358681003550 putative Zn2+ binding site [ion binding]; other site 358681003551 AsnC family; Region: AsnC_trans_reg; pfam01037 358681003552 EamA-like transporter family; Region: EamA; pfam00892 358681003553 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 358681003554 EamA-like transporter family; Region: EamA; pfam00892 358681003555 Response regulator of citrate/malate metabolism [Transcription / Signal transduction mechanisms]; Region: CitB; COG4565 358681003556 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 358681003557 active site 358681003558 phosphorylation site [posttranslational modification] 358681003559 intermolecular recognition site; other site 358681003560 dimerization interface [polypeptide binding]; other site 358681003561 Transcriptional regulator; Region: CitT; pfam12431 358681003562 Signal transduction histidine kinase regulating citrate/malate metabolism [Signal transduction mechanisms]; Region: CitA; COG3290 358681003563 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459 358681003564 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 358681003565 ATP binding site [chemical binding]; other site 358681003566 Mg2+ binding site [ion binding]; other site 358681003567 G-X-G motif; other site 358681003568 cytochrome o ubiquinol oxidase subunit II; Provisional; Region: PRK10525 358681003569 Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; pfam00116 358681003570 Heme/copper-type cytochrome/quinol oxidases, subunit 1 [Energy production and conversion]; Region: CyoB; COG0843 358681003571 Ubiquinol oxidase subunit I. Ubiquinol oxidase, the terminal oxidase in the respiratory chains of aerobic bacteria, is a multi-chain transmembrane protein located in the cell membrane. It catalyzes the reduction of O2 and simultaneously pumps protons...; Region: Ubiquinol_Oxidase_I; cd01662 358681003572 D-pathway; other site 358681003573 Putative ubiquinol binding site [chemical binding]; other site 358681003574 Low-spin heme (heme b) binding site [chemical binding]; other site 358681003575 Putative water exit pathway; other site 358681003576 Binuclear center (heme o3/CuB) [ion binding]; other site 358681003577 K-pathway; other site 358681003578 Putative proton exit pathway; other site 358681003579 Ubiquinol oxidase subunit III subfamily. Ubiquinol oxidase, the terminal oxidase in the respiratory chains of aerobic bacteria, is a multi-chain transmembrane protein located in the cell membrane. It catalyzes the reduction of O2 and simultaneously...; Region: Ubiquinol_oxidase_III; cd02863 358681003580 Subunit I/III interface [polypeptide binding]; other site 358681003581 Subunit III/IV interface [polypeptide binding]; other site 358681003582 cytochrome o ubiquinol oxidase subunit IV; Region: CyoD; TIGR02847 358681003583 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 358681003584 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 358681003585 Coenzyme A binding pocket [chemical binding]; other site 358681003586 YpjP-like protein; Region: YpjP; pfam14005 358681003587 Thioredoxin reductase [Posttranslational modification, protein turnover, chaperones]; Region: TrxB; COG0492 358681003588 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 358681003589 BlaR1 peptidase M56; Region: Peptidase_M56; pfam05569 358681003590 Beta-lactamase class D [Defense mechanisms]; Region: COG2602 358681003591 copper transport repressor, CopY/TcrY family; Region: CopY_TcrY; TIGR02698 358681003592 Penicillinase repressor; Region: Pencillinase_R; pfam03965 358681003593 Beta-lactamase class A [Defense mechanisms]; Region: PenP; COG2367 358681003594 Beta-lactamase enzyme family; Region: Beta-lactamase2; pfam13354 358681003595 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 358681003596 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 358681003597 phosphopeptide binding site; other site 358681003598 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 358681003599 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 358681003600 DNA binding site [nucleotide binding] 358681003601 Major Facilitator Superfamily; Region: MFS_1; pfam07690 358681003602 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 358681003603 putative substrate translocation pore; other site 358681003604 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 358681003605 Predicted transcriptional regulators [Transcription]; Region: COG1695 358681003606 Transcriptional regulator PadR-like family; Region: PadR; cl17335 358681003607 Domain of unknown function (DUF3817); Region: DUF3817; pfam12823 358681003608 ADP-ribosylglycohydrolase; Region: ADP_ribosyl_GH; pfam03747 358681003609 Protein of unknown function (DUF3231); Region: DUF3231; pfam11553 358681003610 Protein of unknown function (DUF2512); Region: DUF2512; pfam10710 358681003611 TATA Binding Protein (TBP) Associated Factor 9 (TAF9) is one of several TAFs that bind TBP and is involved in forming Transcription Factor IID (TFIID) complex; Region: TAF9; cl17378 358681003612 RNA polymerase sigma factor; Provisional; Region: PRK12543 358681003613 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 358681003614 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 358681003615 DNA binding residues [nucleotide binding] 358681003616 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 358681003617 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 358681003618 Walker A/P-loop; other site 358681003619 ATP binding site [chemical binding]; other site 358681003620 Q-loop/lid; other site 358681003621 ABC transporter signature motif; other site 358681003622 Walker B; other site 358681003623 D-loop; other site 358681003624 H-loop/switch region; other site 358681003625 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 358681003626 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 358681003627 substrate binding pocket [chemical binding]; other site 358681003628 membrane-bound complex binding site; other site 358681003629 hinge residues; other site 358681003630 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 358681003631 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 358681003632 dimer interface [polypeptide binding]; other site 358681003633 conserved gate region; other site 358681003634 putative PBP binding loops; other site 358681003635 ABC-ATPase subunit interface; other site 358681003636 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 358681003637 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 358681003638 dimer interface [polypeptide binding]; other site 358681003639 conserved gate region; other site 358681003640 putative PBP binding loops; other site 358681003641 ABC-ATPase subunit interface; other site 358681003642 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 358681003643 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 358681003644 ATP binding site [chemical binding]; other site 358681003645 G-X-G motif; other site 358681003646 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 358681003647 Response regulator receiver domain; Region: Response_reg; pfam00072 358681003648 active site 358681003649 phosphorylation site [posttranslational modification] 358681003650 intermolecular recognition site; other site 358681003651 dimerization interface [polypeptide binding]; other site 358681003652 YcbB domain; Region: YcbB; pfam08664 358681003653 ABC-type Na+ transport system, ATPase component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatA; COG4555 358681003654 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 358681003655 Walker A/P-loop; other site 358681003656 ATP binding site [chemical binding]; other site 358681003657 Q-loop/lid; other site 358681003658 ABC transporter signature motif; other site 358681003659 Walker B; other site 358681003660 D-loop; other site 358681003661 H-loop/switch region; other site 358681003662 ABC-type transport system involved in multi-copper enzyme maturation, permease component [General function prediction only]; Region: NosY; COG1277 358681003663 NosL; Region: NosL; cl01769 358681003664 nitrous oxide reductase family maturation protein NosD; Region: NosD_copper_fam; TIGR04247 358681003665 parallel beta-helix repeat (two copies); Region: para_beta_helix; TIGR03804 358681003666 parallel beta-helix repeat (two copies); Region: para_beta_helix; TIGR03804 358681003667 parallel beta-helix repeat (two copies); Region: para_beta_helix; TIGR03804 358681003668 Glutamate synthase domain 2 [Amino acid transport and metabolism]; Region: GltB; COG0069 358681003669 Glutamate synthase (GltS) FMN-binding domain. GltS is a complex iron-sulfur flavoprotein that catalyzes the reductive synthesis of L-glutamate from 2-oxoglutarate and L-glutamine via intramolecular channelling of ammonia, a reaction in the plant, yeast...; Region: GltS_FMN; cd02808 358681003670 active site 358681003671 FMN binding site [chemical binding]; other site 358681003672 substrate binding site [chemical binding]; other site 358681003673 3Fe-4S cluster binding site [ion binding]; other site 358681003674 Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450 358681003675 Peroxiredoxin (PRX) family, Typical 2-Cys PRX subfamily; PRXs are thiol-specific antioxidant (TSA) proteins, which confer a protective role in cells through its peroxidase activity by reducing hydrogen peroxide, peroxynitrite, and organic hydroperoxides; Region: PRX_Typ2cys; cd03015 358681003676 dimer interface [polypeptide binding]; other site 358681003677 decamer (pentamer of dimers) interface [polypeptide binding]; other site 358681003678 catalytic triad [active] 358681003679 peroxidatic and resolving cysteines [active] 358681003680 Uncharacterized proteins involved in stress response, similar to tellurium resistance terD; Region: TerD_like; cd06974 358681003681 putative metal binding site [ion binding]; other site 358681003682 ThiF family; Region: ThiF; pfam00899 358681003683 ATP binding site [chemical binding]; other site 358681003684 thiazole biosynthesis adenylyltransferase ThiF, E. coli subfamily; Region: adenyl_thiF; TIGR02356 358681003685 ATP binding site [chemical binding]; other site 358681003686 substrate interface [chemical binding]; other site 358681003687 ThiF family; Region: ThiF; pfam00899 358681003688 Protein of unknown function (DUF441); Region: DUF441; cl01041 358681003689 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 358681003690 alpha/beta hydrolase fold; Region: Abhydrolase_1; pfam00561 358681003691 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 358681003692 homocitrate synthase; Region: LysS_fung_arch; TIGR02146 358681003693 DRE-TIM metallolyase superfamily; Region: DRE_TIM_metallolyase; cl07974 358681003694 active site 358681003695 catalytic residues [active] 358681003696 metal binding site [ion binding]; metal-binding site 358681003697 D-ala-D-ala dipeptidase; Region: Peptidase_M15; cl00813 358681003698 ATP:corrinoid adenosyltransferase [Coenzyme metabolism]; Region: BtuR; COG2109 358681003699 ATP:corrinoid adenosyltransferase BtuR/CobO/CobP. This family consists of the BtuR, CobO, CobP proteins all of which are Cob(I)alamin (vitamin B12) adenosyltransferase, which is involved in cobalamin (vitamin B12) biosynthesis. This enzyme is a homodimer; Region: CobA_CobO_BtuR; cd00561 358681003700 homodimer interface [polypeptide binding]; other site 358681003701 Walker A motif; other site 358681003702 ATP binding site [chemical binding]; other site 358681003703 hydroxycobalamin binding site [chemical binding]; other site 358681003704 Walker B motif; other site 358681003705 L-threonine-O-3-phosphate decarboxylase; Region: L_thr_O3P_dcar; TIGR01140 358681003706 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 358681003707 pyridoxal 5'-phosphate binding site [chemical binding]; other site 358681003708 homodimer interface [polypeptide binding]; other site 358681003709 catalytic residue [active] 358681003710 Adenosylcobinamide kinase / adenosylcobinamide phosphate guanyltransferase (CobU). CobU is bifunctional cobalbumin biosynthesis enzymes which display adenosylcobinamide kinase and adenosylcobinamide phosphate guanyltransferase activity. This enzyme is a...; Region: CobU; cd00544 358681003711 homotrimer interface [polypeptide binding]; other site 358681003712 Walker A motif; other site 358681003713 GTP binding site [chemical binding]; other site 358681003714 Walker B motif; other site 358681003715 cobalamin synthase; Reviewed; Region: cobS; PRK00235 358681003716 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 358681003717 catalytic core [active] 358681003718 CobD/Cbib protein; Region: CobD_Cbib; pfam03186 358681003719 Precorrin-3B C(17)-methyltransferase (CobJ/CbiH); Region: Precorrin_3B_C17_MT; cd11646 358681003720 active site 358681003721 SAM binding site [chemical binding]; other site 358681003722 homodimer interface [polypeptide binding]; other site 358681003723 Nitrite and sulphite reductase 4Fe-4S domain; Region: NIR_SIR; pfam01077 358681003724 Sirohydrochlorin ferrochelatase [Inorganic ion transport and metabolism]; Region: COG2138 358681003725 Sirohydrochlorin cobalt chelatase (CbiX) and sirohydrochlorin iron chelatase (SirB), N-terminal domain. SirB catalyzes the ferro-chelation of sirohydrochlorin to siroheme, the prosthetic group of sulfite and nitrite reductases. CbiX is a cobaltochelatase; Region: CbiX_SirB_N; cd03416 358681003726 putative active site [active] 358681003727 Sirohydrochlorin cobalt chelatase (CbiX) and sirohydrochlorin iron chelatase (SirB), C-terminal domain. SirB catalyzes the ferro-chelation of sirohydrochlorin to siroheme, the prosthetic group of sulfite and nitrite reductases. CbiX is a cobaltochelatase; Region: CbiX_SirB_C; cd03414 358681003728 putative active site [active] 358681003729 Precorrin-6x reductase [Coenzyme metabolism]; Region: CobK; COG2099 358681003730 Precorrin-6x reductase CbiJ/CobK; Region: CbiJ; pfam02571 358681003731 cobalt-precorrin-8X methylmutase; Validated; Region: cbiC; cl00913 358681003732 Precorrin-8X methylmutase; Region: CbiC; pfam02570 358681003733 cobalt-precorrin-6A synthase; Reviewed; Region: cbiD; PRK00075 358681003734 Precorrin-6Y methyltransferase, the cobalamin biosynthesis enzyme CbiE; Region: Precorrin-6Y-methylase; cd11644 358681003735 active site 358681003736 putative homodimer interface [polypeptide binding]; other site 358681003737 SAM binding site [chemical binding]; other site 358681003738 Precorrin-6B methylase 2 [Coenzyme metabolism]; Region: CobL; COG2242 358681003739 precorrin-6Y C5,15-methyltransferase (decarboxylating), CbiT subunit; Region: CbiT; TIGR02469 358681003740 Precorrin-2 C20-methyltransferase, also named CobI or CbiL; Region: Precorrin_2_C20_MT; cd11645 358681003741 active site 358681003742 SAM binding site [chemical binding]; other site 358681003743 homodimer interface [polypeptide binding]; other site 358681003744 Diphthamide biosynthesis methyltransferase [Translation, ribosomal structure and biogenesis]; Region: DPH5; COG1798 358681003745 Precorrin-4 C11-methyltransferase (CbiF/CobM); Region: Precorrin-4_C11-MT; cd11641 358681003746 active site 358681003747 SAM binding site [chemical binding]; other site 358681003748 homodimer interface [polypeptide binding]; other site 358681003749 cobalamin biosynthesis protein CbiG; Validated; Region: PRK05788 358681003750 Cobalamin synthesis G N-terminal; Region: CbiG_N; pfam11760 358681003751 Cobalamin biosynthesis central region; Region: CbiG_mid; pfam11761 358681003752 Cobalamin synthesis G C-terminus; Region: CbiG_C; pfam01890 358681003753 cobyrinic acid a,c-diamide synthase; Validated; Region: PRK01077 358681003754 dithiobiotin synthetase; Reviewed; Region: bioD; PRK00090 358681003755 Type 1 glutamine amidotransferase (GATase1) domain found in Cobyrinic Acid a,c-Diamide Synthase; Region: GATase1_CobB; cd03130 358681003756 catalytic triad [active] 358681003757 cobyric acid synthase; Provisional; Region: PRK00784 358681003758 Dethiobiotin synthetase [Coenzyme metabolism]; Region: BioD; COG0132 358681003759 Type 1 glutamine amidotransferase (GATase1) domain found in Cobyric Acid Synthase (CobQ); Region: GATase1_CobQ; cd01750 358681003760 catalytic triad [active] 358681003761 Phosphoribosyltransferase; Region: DBI_PRT; pfam02277 358681003762 Nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase (DMB-PRT), also called CobT; Region: DMB-PRT_CobT; cd02439 358681003763 putative dimer interface [polypeptide binding]; other site 358681003764 active site pocket [active] 358681003765 putative cataytic base [active] 358681003766 Uroporphyrin-III C-methyltransferase (S-Adenosyl-L-methionine:uroporphyrinogen III methyltransferase, SUMT); Region: SUMT; cd11642 358681003767 active site 358681003768 SAM binding site [chemical binding]; other site 358681003769 homodimer interface [polypeptide binding]; other site 358681003770 Siroheme synthase (precorrin-2 oxidase/ferrochelatase domain) [Coenzyme metabolism]; Region: CysG; COG1648 358681003771 Putative NAD(P)-binding; Region: NAD_binding_7; pfam13241 358681003772 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 358681003773 Coenzyme A binding pocket [chemical binding]; other site 358681003774 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966 358681003775 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 358681003776 catalytic residues [active] 358681003777 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; COG0475 358681003778 Sodium/hydrogen exchanger family; Region: Na_H_Exchanger; pfam00999 358681003779 Putative regulatory, ligand-binding protein related to C-terminal domains of K+ channels [Inorganic ion transport and metabolism]; Region: COG0490 358681003780 TrkA-C domain; Region: TrkA_C; pfam02080 358681003781 C4-dicarboxylate transporter DctA; Reviewed; Region: PRK01663 358681003782 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 358681003783 Copper amine oxidase N-terminal domain; Region: Cu_amine_oxidN1; pfam07833 358681003784 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 358681003785 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 358681003786 active site 358681003787 phosphorylation site [posttranslational modification] 358681003788 intermolecular recognition site; other site 358681003789 dimerization interface [polypeptide binding]; other site 358681003790 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 358681003791 DNA binding site [nucleotide binding] 358681003792 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 358681003793 HAMP domain; Region: HAMP; pfam00672 358681003794 dimerization interface [polypeptide binding]; other site 358681003795 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 358681003796 dimer interface [polypeptide binding]; other site 358681003797 phosphorylation site [posttranslational modification] 358681003798 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 358681003799 ATP binding site [chemical binding]; other site 358681003800 Mg2+ binding site [ion binding]; other site 358681003801 G-X-G motif; other site 358681003802 TRAP-type C4-dicarboxylate transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: DctP; COG1638 358681003803 Bacterial extracellular solute-binding protein, family 7; Region: SBP_bac_7; pfam03480 358681003804 Signal transduction histidine kinase regulating citrate/malate metabolism [Signal transduction mechanisms]; Region: CitA; COG3290 358681003805 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 358681003806 putative active site [active] 358681003807 heme pocket [chemical binding]; other site 358681003808 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 358681003809 ATP binding site [chemical binding]; other site 358681003810 Mg2+ binding site [ion binding]; other site 358681003811 G-X-G motif; other site 358681003812 Response regulator of citrate/malate metabolism [Transcription / Signal transduction mechanisms]; Region: CitB; COG4565 358681003813 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 358681003814 active site 358681003815 phosphorylation site [posttranslational modification] 358681003816 intermolecular recognition site; other site 358681003817 dimerization interface [polypeptide binding]; other site 358681003818 IclR helix-turn-helix domain; Region: HTH_IclR; cl17605 358681003819 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 358681003820 PAS domain; Region: PAS_9; pfam13426 358681003821 putative active site [active] 358681003822 heme pocket [chemical binding]; other site 358681003823 psp operon transcriptional activator PspF; Region: phageshock_pspF; TIGR02974 358681003824 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 358681003825 Walker A motif; other site 358681003826 ATP binding site [chemical binding]; other site 358681003827 Walker B motif; other site 358681003828 arginine finger; other site 358681003829 Bacterial regulatory protein, Fis family; Region: HTH_8; cl17420 358681003830 LD-Carboxypeptidase, a serine protease, includes microcin C7 self immunity protein; Region: Peptidase_S66; cd07025 358681003831 dimer interface [polypeptide binding]; other site 358681003832 catalytic triad [active] 358681003833 Domain of unknown function (DUF4280); Region: DUF4280; pfam14107 358681003834 Phage late control gene D protein (GPD); Region: Phage_GPD; pfam05954 358681003835 SMI1 / KNR4 family (SUKH-1); Region: SMI1_KNR4; pfam09346 358681003836 YwqJ-like deaminase; Region: YwqJ-deaminase; pfam14431 358681003837 SUKH-3 immunity protein; Region: SUKH-3; pfam14433 358681003838 The BURPS668_1122 family of deaminases; Region: Toxin-deaminase; pfam14424 358681003839 SMI1 / KNR4 family (SUKH-1); Region: SMI1_KNR4; cl01747 358681003840 The BURPS668_1122 family of deaminases; Region: Toxin-deaminase; pfam14424 358681003841 Immunity protein Imm3; Region: Imm3; pfam14425 358681003842 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 358681003843 Histidine kinase; Region: HisKA_3; pfam07730 358681003844 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 358681003845 ATP binding site [chemical binding]; other site 358681003846 Mg2+ binding site [ion binding]; other site 358681003847 G-X-G motif; other site 358681003848 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 358681003849 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 358681003850 active site 358681003851 phosphorylation site [posttranslational modification] 358681003852 intermolecular recognition site; other site 358681003853 dimerization interface [polypeptide binding]; other site 358681003854 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 358681003855 DNA binding residues [nucleotide binding] 358681003856 dimerization interface [polypeptide binding]; other site 358681003857 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 358681003858 Beta-lactamase; Region: Beta-lactamase; pfam00144 358681003859 S-layer homology domain; Region: SLH; pfam00395 358681003860 Putative sensor; Region: Sensor; pfam13796 358681003861 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 358681003862 Histidine kinase; Region: HisKA_3; pfam07730 358681003863 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 358681003864 ATP binding site [chemical binding]; other site 358681003865 Mg2+ binding site [ion binding]; other site 358681003866 G-X-G motif; other site 358681003867 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 358681003868 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 358681003869 active site 358681003870 phosphorylation site [posttranslational modification] 358681003871 intermolecular recognition site; other site 358681003872 dimerization interface [polypeptide binding]; other site 358681003873 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 358681003874 DNA binding residues [nucleotide binding] 358681003875 dimerization interface [polypeptide binding]; other site 358681003876 S-layer homology domain; Region: SLH; pfam00395 358681003877 S-layer homology domain; Region: SLH; pfam00395 358681003878 Immunity protein Imm3; Region: Imm3; pfam14425 358681003879 Nucleotidyl transferase of unknown function (DUF1814); Region: DUF1814; pfam08843 358681003880 Choline dehydrogenase and related flavoproteins [Amino acid transport and metabolism]; Region: BetA; COG2303 358681003881 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 358681003882 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 358681003883 Domain of Unknown Function (DUF1259); Region: DUF1529; pfam07485 358681003884 Domain of Unknown Function (DUF1259); Region: DUF1529; pfam07485 358681003885 Immunity protein Imm3; Region: Imm3; pfam14425 358681003886 DNA-binding ferritin-like protein (oxidative damage protectant) [Inorganic ion transport and metabolism]; Region: Dps; COG0783 358681003887 DPS protein, ferritin-like diiron-binding domain; Region: DPS; cd01043 358681003888 dimerization interface [polypeptide binding]; other site 358681003889 DPS ferroxidase diiron center [ion binding]; other site 358681003890 ion pore; other site 358681003891 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 358681003892 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 358681003893 pantothenate kinase; Provisional; Region: PRK05439 358681003894 Pantothenate kinase (PanK) catalyzes the phosphorylation of pantothenic acid to form 4'-phosphopantothenic, which is the first of five steps in coenzyme A (CoA) biosynthetic pathway. The reaction carried out by this enzyme is a key regulatory point...; Region: PanK; cd02025 358681003895 ATP-binding site [chemical binding]; other site 358681003896 CoA-binding site [chemical binding]; other site 358681003897 Mg2+-binding site [ion binding]; other site 358681003898 Uncharacterized conserved protein [Function unknown]; Region: COG1683 358681003899 BCCT family transporter; Region: BCCT; pfam02028 358681003900 Transcriptional regulator [Transcription]; Region: LysR; COG0583 358681003901 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 358681003902 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 358681003903 dimerization interface [polypeptide binding]; other site 358681003904 Xanthine/uracil/vitamin C permease [Nucleotide transport and metabolism]; Region: COG2252 358681003905 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 358681003906 DNA-binding site [nucleotide binding]; DNA binding site 358681003907 HPP family; Region: HPP; pfam04982 358681003908 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 358681003909 global nitrogen regulator NtcA, cyanobacterial; Region: NtcA_cyano; TIGR03697 358681003910 ligand binding site [chemical binding]; other site 358681003911 flexible hinge region; other site 358681003912 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 358681003913 putative switch regulator; other site 358681003914 non-specific DNA interactions [nucleotide binding]; other site 358681003915 DNA binding site [nucleotide binding] 358681003916 sequence specific DNA binding site [nucleotide binding]; other site 358681003917 putative cAMP binding site [chemical binding]; other site 358681003918 conserved hypothetical integral membrane protein; Region: TIGR00697 358681003919 Replication protein A, class 2b aminoacyl-tRNA synthetases, and related proteins with oligonucleotide/oligosaccharide (OB) fold; Region: RPA_2b-aaRSs_OBF_like; cl09930 358681003920 generic binding surface I; other site 358681003921 generic binding surface II; other site 358681003922 Fn3 associated; Region: Fn3_assoc; pfam13287 358681003923 YhcR_OBF_like: A subfamily of OB-fold domains similar to the OB folds of Bacillus subtilis YhcR. YhcR is a sugar-nonspecific nuclease, which is active in the presence of Ca2+ and Mn2+. It cleaves RNA endonucleolytically, producing 3'-monophosphate...; Region: YhcR_OBF_like; cd04486 358681003924 generic binding surface II; other site 358681003925 generic binding surface I; other site 358681003926 Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490 358681003927 putative catalytic site [active] 358681003928 putative metal binding site [ion binding]; other site 358681003929 putative phosphate binding site [ion binding]; other site 358681003930 Uncharacterized homolog of gamma-carboxymuconolactone decarboxylase subunit [Function unknown]; Region: COG0599 358681003931 Uncharacterized homolog of gamma-carboxymuconolactone decarboxylase subunit [Function unknown]; Region: COG0599 358681003932 Helix-Turn-Helix DNA binding domain of the MerR-like transcription regulators YyaN and YraB; Region: HTH_YyaN; cd01109 358681003933 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 358681003934 DNA binding residues [nucleotide binding] 358681003935 putative dimer interface [polypeptide binding]; other site 358681003936 tryptophanyl-tRNA synthetase II; Reviewed; Region: PRK12282 358681003937 catalytic core domain of tryptophanyl-tRNA synthetase; Region: TrpRS_core; cd00806 358681003938 active site 358681003939 HIGH motif; other site 358681003940 dimer interface [polypeptide binding]; other site 358681003941 KMSKS motif; other site 358681003942 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 358681003943 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 358681003944 Protein of unknown function with HXXEE motif; Region: HXXEE; pfam13787 358681003945 Predicted transcriptional regulator [Transcription]; Region: COG2345 358681003946 Zinc metalloprotease (elastase) [Amino acid transport and metabolism]; Region: LasB; COG3227 358681003947 Fungalysin/Thermolysin Propeptide Motif; Region: FTP; pfam07504 358681003948 Peptidase propeptide and YPEB domain; Region: PepSY; pfam03413 358681003949 Peptidase M4 family includes thermolysin, protealysin, aureolysin and neutral protease; Region: M4_neutral_protease; cd09597 358681003950 active site 358681003951 Zn binding site [ion binding]; other site 358681003952 Phosphotransferase enzyme family; Region: APH; pfam01636 358681003953 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cd05120 358681003954 active site 358681003955 substrate binding site [chemical binding]; other site 358681003956 ATP binding site [chemical binding]; other site 358681003957 allantoate amidohydrolase; Reviewed; Region: PRK09290 358681003958 M20 Peptidase beta-alanine synthase, an amidohydrolase; Region: M20_bAS; cd03884 358681003959 active site 358681003960 metal binding site [ion binding]; metal-binding site 358681003961 dimer interface [polypeptide binding]; other site 358681003962 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 358681003963 M20 Peptidase Aminoacylase 1 family; Region: M20_Acy1; cd03886 358681003964 metal binding site [ion binding]; metal-binding site 358681003965 dimer interface [polypeptide binding]; other site 358681003966 Concanavalin A-like lectin/glucanases superfamily; Region: Laminin_G_3; pfam13385 358681003967 Bacterial surface proteins containing Ig-like domains [Cell motility and secretion]; Region: COG5492 358681003968 Bacterial Ig-like domain (group 2); Region: Big_2; pfam02368 358681003969 Type I phosphodiesterase / nucleotide pyrophosphatase; Region: Phosphodiest; pfam01663 358681003970 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 358681003971 DNA binding residues [nucleotide binding] 358681003972 Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220 358681003973 metal-dependent hydrolase; Provisional; Region: PRK00685 358681003974 TspO/MBR family; Region: TspO_MBR; pfam03073 358681003975 N-ethylammeline chlorohydrolase; Provisional; Region: PRK06038 358681003976 TRZ/ATZ family contains enzymes from the atrazine degradation pathway and related hydrolases. Atrazine, a chlorinated herbizide, can be catabolized by a variety of different bacteria. The first three steps of the atrazine dehalogenation pathway are...; Region: ATZ_TRZ_like; cd01298 358681003977 active site 358681003978 putative substrate binding pocket [chemical binding]; other site 358681003979 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 358681003980 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 358681003981 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 358681003982 putative active site [active] 358681003983 Beta-lactamase; Region: Beta-lactamase; cl17358 358681003984 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 358681003985 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 358681003986 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 358681003987 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 358681003988 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 358681003989 dimer interface [polypeptide binding]; other site 358681003990 conserved gate region; other site 358681003991 putative PBP binding loops; other site 358681003992 ABC-ATPase subunit interface; other site 358681003993 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 358681003994 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 358681003995 dimer interface [polypeptide binding]; other site 358681003996 conserved gate region; other site 358681003997 putative PBP binding loops; other site 358681003998 ABC-ATPase subunit interface; other site 358681003999 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 358681004000 nucleotide binding site [chemical binding]; other site 358681004001 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 358681004002 FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202 358681004003 putative active site [active] 358681004004 heme pocket [chemical binding]; other site 358681004005 Signal transduction histidine kinase, nitrogen specific [Signal transduction mechanisms]; Region: NtrB; COG3852 358681004006 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 358681004007 putative active site [active] 358681004008 heme pocket [chemical binding]; other site 358681004009 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 358681004010 dimer interface [polypeptide binding]; other site 358681004011 phosphorylation site [posttranslational modification] 358681004012 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 358681004013 ATP binding site [chemical binding]; other site 358681004014 Mg2+ binding site [ion binding]; other site 358681004015 G-X-G motif; other site 358681004016 Domain of unknown function (DUF3870); Region: DUF3870; pfam12986 358681004017 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 358681004018 GAF domain; Region: GAF_3; pfam13492 358681004019 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 358681004020 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 358681004021 metal binding site [ion binding]; metal-binding site 358681004022 active site 358681004023 I-site; other site 358681004024 Na+/H+ antiporter NhaC; Region: antiport_nhaC; TIGR00931 358681004025 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_2; pfam07992 358681004026 NrdH-redoxin (NrdH) family; NrdH is a small monomeric protein with a conserved redox active CXXC motif within a TRX fold, characterized by a glutaredoxin (GRX)-like sequence and TRX-like activity profile. In vitro, it displays protein disulfide reductase...; Region: NrdH; cd02976 358681004027 catalytic residues [active] 358681004028 Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450 358681004029 Peroxiredoxin (PRX) family, Typical 2-Cys PRX subfamily; PRXs are thiol-specific antioxidant (TSA) proteins, which confer a protective role in cells through its peroxidase activity by reducing hydrogen peroxide, peroxynitrite, and organic hydroperoxides; Region: PRX_Typ2cys; cd03015 358681004030 decamer (pentamer of dimers) interface [polypeptide binding]; other site 358681004031 catalytic triad [active] 358681004032 dimer interface [polypeptide binding]; other site 358681004033 peroxidatic and resolving cysteines [active] 358681004034 Thioredoxin reductase [Posttranslational modification, protein turnover, chaperones]; Region: TrxB; COG0492 358681004035 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 358681004036 HEAT repeats; Region: HEAT_2; pfam13646 358681004037 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 358681004038 CESA_like is the cellulose synthase superfamily; Region: CESA_like; cd06423 358681004039 DXD motif; other site 358681004040 Response regulator receiver domain; Region: Response_reg; pfam00072 358681004041 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 358681004042 active site 358681004043 phosphorylation site [posttranslational modification] 358681004044 intermolecular recognition site; other site 358681004045 dimerization interface [polypeptide binding]; other site 358681004046 UDP-N-acetyl-D-mannosaminuronate dehydrogenase [Cell envelope biogenesis, outer membrane]; Region: WecC; COG0677 358681004047 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 358681004048 UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984 358681004049 UDP binding domain; Region: UDPG_MGDP_dh_C; smart00984 358681004050 glucosamine--fructose-6-phosphate aminotransferase; Reviewed; Region: PRK00331 358681004051 Glutamine amidotransferases class-II (Gn-AT)_GFAT-type. This domain is found at the N-terminus of glucosamine-6P synthase (GlmS, or GFAT in humans). The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the appropriate substrate. In...; Region: GFAT; cd00714 358681004052 glutaminase active site [active] 358681004053 SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008 358681004054 dimer interface [polypeptide binding]; other site 358681004055 active site 358681004056 SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009 358681004057 dimer interface [polypeptide binding]; other site 358681004058 active site 358681004059 dTDP-glucose pyrophosphorylase [Cell envelope biogenesis, outer membrane]; Region: RfbA; COG1209 358681004060 N-terminal domain of bacterial GlmU; Region: GT2_GlmU_N_bac; cd02540 358681004061 Substrate binding site; other site 358681004062 Mg++ binding site; other site 358681004063 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 358681004064 YheC/D like ATP-grasp; Region: ATPgrasp_YheCD; pfam14398 358681004065 YheC/D like ATP-grasp; Region: ATPgrasp_YheCD; pfam14398 358681004066 YheC/D like ATP-grasp; Region: ATPgrasp_YheCD; pfam14398 358681004067 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 358681004068 YheC/D like ATP-grasp; Region: ATPgrasp_YheCD; pfam14398 358681004069 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4399 358681004070 Predicted transcriptional regulator containing CBS domains [Transcription]; Region: COG4109 358681004071 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 358681004072 DNA-binding site [nucleotide binding]; DNA binding site 358681004073 DRTGG domain; Region: DRTGG; pfam07085 358681004074 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with a DRTGG domain upstream. The function of the DRTGG domain, named after its conserved residues, is unknown. CBS is a small domain originally...; Region: CBS_pair_DRTGG_assoc; cd04596 358681004075 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cd03440 358681004076 active site 2 [active] 358681004077 active site 1 [active] 358681004078 H+ Antiporter protein; Region: 2A0121; TIGR00900 358681004079 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 358681004080 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 358681004081 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 358681004082 putative DNA binding site [nucleotide binding]; other site 358681004083 dimerization interface [polypeptide binding]; other site 358681004084 putative Zn2+ binding site [ion binding]; other site 358681004085 Uncharacterized protein conserved in bacteria (DUF2087); Region: DUF2087; cl01589 358681004086 YtpI-like protein; Region: YtpI; pfam14007 358681004087 DNA polymerase III DnaE; Reviewed; Region: dnaE; PRK06826 358681004088 Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III DnaE3; Region: PHP_PolIIIA_DnaE3; cd12113 358681004089 active site 358681004090 PHP Thumb interface [polypeptide binding]; other site 358681004091 metal binding site [ion binding]; metal-binding site 358681004092 DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485 358681004093 generic binding surface II; other site 358681004094 generic binding surface I; other site 358681004095 Malic enzyme [Energy production and conversion]; Region: SfcA; COG0281 358681004096 Malic enzyme, N-terminal domain; Region: malic; pfam00390 358681004097 NAD(P) binding domain of malic enzyme (ME), subgroup 2; Region: NAD_bind_2_malic_enz; cd05311 358681004098 putative NAD(P) binding site [chemical binding]; other site 358681004099 Transcriptional regulators [Transcription]; Region: FadR; COG2186 358681004100 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 358681004101 DNA-binding site [nucleotide binding]; DNA binding site 358681004102 FCD domain; Region: FCD; pfam07729 358681004103 4-aminobutyrate transaminase; Provisional; Region: PRK09792 358681004104 acetyl-CoA carboxylase subunit beta; Validated; Region: PRK05654 358681004105 malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682 358681004106 acetyl-CoA carboxylase carboxyltransferase subunit alpha; Validated; Region: PRK05724 358681004107 acetyl-CoA carboxylase carboxyltransferase alpha subunit; Provisional; Region: accA; CHL00198 358681004108 6-phosphofructokinase; Provisional; Region: PRK03202 358681004109 6-phosphofructokinase; Region: PFKA_ATP; TIGR02482 358681004110 active site 358681004111 ADP/pyrophosphate binding site [chemical binding]; other site 358681004112 dimerization interface [polypeptide binding]; other site 358681004113 allosteric effector site; other site 358681004114 fructose-1,6-bisphosphate binding site; other site 358681004115 pyruvate kinase; Provisional; Region: PRK06354 358681004116 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl17342 358681004117 domain interfaces; other site 358681004118 active site 358681004119 Phosphohistidine swiveling domain [Signal transduction mechanisms]; Region: COG3848 358681004120 ribonucleoside-triphosphate reductase, adenosylcobalamin-dependent; Region: RTPR; TIGR02505 358681004121 Ribonucleotide reductase and Pyruvate formate lyase; Region: RNR_PFL; cl09939 358681004122 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 358681004123 active site 358681004124 FxsA cytoplasmic membrane protein; Region: FxsA; pfam04186 358681004125 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; cl00465 358681004126 Bacillus subtilis (Bs) citrate synthase (CS)-II_like. CS catalyzes the condensation of acetyl coenzyme A (AcCoA) and oxalacetate (OAA) to form citrate and coenzyme A (CoA), the first step in the citric acid cycle (TCA or Krebs cycle). 2MCS catalyzes the...; Region: BSuCS-II_like; cd06110 358681004127 dimer interface [polypeptide binding]; other site 358681004128 Citrate synthase; Region: Citrate_synt; pfam00285 358681004129 active site 358681004130 citrylCoA binding site [chemical binding]; other site 358681004131 oxalacetate/citrate binding site [chemical binding]; other site 358681004132 coenzyme A binding site [chemical binding]; other site 358681004133 catalytic triad [active] 358681004134 isocitrate dehydrogenase; Validated; Region: PRK07362 358681004135 isocitrate dehydrogenase; Reviewed; Region: PRK07006 358681004136 malate dehydrogenase; Reviewed; Region: PRK06223 358681004137 L-lactate dehydrogenase-like malate dehydrogenase proteins; Region: LDH-like_MDH; cd01339 358681004138 NAD(P) binding site [chemical binding]; other site 358681004139 dimer interface [polypeptide binding]; other site 358681004140 tetramer (dimer of dimers) interface [polypeptide binding]; other site 358681004141 substrate binding site [chemical binding]; other site 358681004142 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 358681004143 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 358681004144 active site 358681004145 phosphorylation site [posttranslational modification] 358681004146 intermolecular recognition site; other site 358681004147 dimerization interface [polypeptide binding]; other site 358681004148 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 358681004149 DNA binding site [nucleotide binding] 358681004150 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 358681004151 dimerization interface [polypeptide binding]; other site 358681004152 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 358681004153 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 358681004154 putative active site [active] 358681004155 heme pocket [chemical binding]; other site 358681004156 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 358681004157 dimer interface [polypeptide binding]; other site 358681004158 phosphorylation site [posttranslational modification] 358681004159 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 358681004160 ATP binding site [chemical binding]; other site 358681004161 Mg2+ binding site [ion binding]; other site 358681004162 G-X-G motif; other site 358681004163 phosphate transport system regulatory protein PhoU; Region: phoU_full; TIGR02135 358681004164 PhoU domain; Region: PhoU; pfam01895 358681004165 PhoU domain; Region: PhoU; pfam01895 358681004166 hypothetical protein; Provisional; Region: PRK06851 358681004167 NTPase; Region: NTPase_1; cl17478 358681004168 Putative peptidoglycan binding domain; Region: PG_binding_4; pfam12229 358681004169 VanW like protein; Region: VanW; pfam04294 358681004170 Transcriptional regulators [Transcription]; Region: MarR; COG1846 358681004171 Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404 358681004172 Multidrug resistance efflux pump [Defense mechanisms]; Region: EmrA; COG1566 358681004173 HlyD family secretion protein; Region: HlyD_3; pfam13437 358681004174 Membrane Fusion Protein cluster 2 (function with RND porters); Region: 8a0102; TIGR00999 358681004175 HlyD family secretion protein; Region: HlyD_3; pfam13437 358681004176 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 358681004177 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 358681004178 putative substrate translocation pore; other site 358681004179 EamA-like transporter family; Region: EamA; pfam00892 358681004180 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 358681004181 EamA-like transporter family; Region: EamA; pfam00892 358681004182 N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860 358681004183 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 358681004184 active site 358681004185 metal binding site [ion binding]; metal-binding site 358681004186 Putative catalytic domain of family 2 polysaccharide deacetylases (DACs) from bacteria; Region: CE4_DAC2; cd10936 358681004187 NodB motif; other site 358681004188 putative active site [active] 358681004189 putative catalytic site [active] 358681004190 Zn binding site [ion binding]; other site 358681004191 DNA polymerase I; Provisional; Region: PRK05755 358681004192 PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859 358681004193 active site 358681004194 metal binding site 1 [ion binding]; metal-binding site 358681004195 putative 5' ssDNA interaction site; other site 358681004196 metal binding site 3; metal-binding site 358681004197 metal binding site 2 [ion binding]; metal-binding site 358681004198 H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898 358681004199 putative DNA binding site [nucleotide binding]; other site 358681004200 putative metal binding site [ion binding]; other site 358681004201 inactive DEDDy 3'-5' exonuclease domain of Bacillus stearothermophilus DNA polymerase I and similar family-A DNA polymerases; Region: DNA_polA_I_Bacillus_like_exo; cd06140 358681004202 Polymerase I functions primarily to fill DNA gaps that arise during DNA repair, recombination and replication; Region: DNA_pol_A_pol_I_C; cd08637 358681004203 active site 358681004204 DNA binding site [nucleotide binding] 358681004205 catalytic site [active] 358681004206 formamidopyrimidine/5-formyluracil/ 5-hydroxymethyluracil DNA glycosylase; Validated; Region: PRK01103 358681004207 N-terminal domain of Escherichia coli Fpg1/MutM and related bacterial DNA glycosylases; Region: EcFpg-like_N; cd08966 358681004208 DNA binding site [nucleotide binding] 358681004209 catalytic residue [active] 358681004210 H2TH interface [polypeptide binding]; other site 358681004211 putative catalytic residues [active] 358681004212 turnover-facilitating residue; other site 358681004213 intercalation triad [nucleotide binding]; other site 358681004214 8OG recognition residue [nucleotide binding]; other site 358681004215 putative reading head residues; other site 358681004216 Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831 358681004217 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 358681004218 Dephospho-CoA kinase [Coenzyme metabolism]; Region: CoaE; COG0237 358681004219 Dephospho-coenzyme A kinase (DPCK, EC 2.7.1.24) catalyzes the phosphorylation of dephosphocoenzyme A (dCoA) to yield CoA, which is the final step in CoA biosynthesis; Region: DPCK; cd02022 358681004220 CoA-binding site [chemical binding]; other site 358681004221 ATP-binding [chemical binding]; other site 358681004222 Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741 358681004223 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 358681004224 N-acetyl-D-glucosamine binding site [chemical binding]; other site 358681004225 catalytic residue [active] 358681004226 glyceraldehyde-3-phosphate dehydrogenase; Validated; Region: PRK07729 358681004227 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; pfam00044 358681004228 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800 358681004229 c-di-GMP phosphodiesterase class II (HD-GYP domain) [Signal transduction mechanisms]; Region: COG2206 358681004230 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 358681004231 Zn2+ binding site [ion binding]; other site 358681004232 Mg2+ binding site [ion binding]; other site 358681004233 transcriptional regulator NrdR; Validated; Region: nrdR; PRK00464 358681004234 ATP cone domain; Region: ATP-cone; pfam03477 358681004235 Replication initiation/membrane attachment protein [DNA replication, recombination, and repair]; Region: DnaB; COG3611 358681004236 Replication initiation and membrane attachment; Region: DnaB_2; pfam07261 358681004237 primosomal protein DnaI; Reviewed; Region: PRK08939 358681004238 Primosomal protein DnaI N-terminus; Region: DnaI_N; pfam07319 358681004239 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 358681004240 Walker A motif; other site 358681004241 ATP binding site [chemical binding]; other site 358681004242 Walker B motif; other site 358681004243 Uncharacterized conserved protein [Function unknown]; Region: COG1434 358681004244 YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259 358681004245 putative active site [active] 358681004246 Bacterial Ig-like domain (group 2); Region: Big_2; cl02708 358681004247 Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280 358681004248 Predicted flavin-nucleotide-binding protein [General function prediction only]; Region: COG3467 358681004249 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 358681004250 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 358681004251 DNA-binding site [nucleotide binding]; DNA binding site 358681004252 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 358681004253 pyridoxal 5'-phosphate binding site [chemical binding]; other site 358681004254 homodimer interface [polypeptide binding]; other site 358681004255 catalytic residue [active] 358681004256 potential frameshift: common BLAST hit: gi|150015561|ref|YP_001307815.1| transposase, mutator type 358681004257 Transposase, Mutator family; Region: Transposase_mut; pfam00872 358681004258 MULE transposase domain; Region: MULE; pfam10551 358681004259 Transposase, Mutator family; Region: Transposase_mut; pfam00872 358681004260 Predicted acyltransferases [Lipid metabolism]; Region: COG1835 358681004261 Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms]; Region: LytT; COG3279 358681004262 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 358681004263 active site 358681004264 phosphorylation site [posttranslational modification] 358681004265 intermolecular recognition site; other site 358681004266 dimerization interface [polypeptide binding]; other site 358681004267 LytTr DNA-binding domain; Region: LytTR; smart00850 358681004268 Putative regulator of cell autolysis [Signal transduction mechanisms]; Region: LytS; COG3275 358681004269 5TMR of 5TMR-LYT; Region: 5TM-5TMR_LYT; pfam07694 358681004270 Histidine kinase; Region: His_kinase; pfam06580 358681004271 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 358681004272 ATP binding site [chemical binding]; other site 358681004273 Mg2+ binding site [ion binding]; other site 358681004274 G-X-G motif; other site 358681004275 alpha-ketoglutarate transporter; Provisional; Region: PRK10406 358681004276 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 358681004277 putative substrate translocation pore; other site 358681004278 ECF-type riboflavin transporter, S component; Region: ECF-ribofla_trS; pfam07155 358681004279 Putative NADPH-quinone reductase (modulator of drug activity B) [General function prediction only]; Region: MdaB; COG2249 358681004280 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 358681004281 Arabinose-binding domain of AraC transcription regulator, N-term; Region: Arabinose_bd; pfam12625 358681004282 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 358681004283 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 358681004284 transcriptional repressor BetI; Region: betaine_BetI; TIGR03384 358681004285 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 358681004286 Bacterial transcriptional repressor; Region: TetR_C_6; pfam13977 358681004287 Domain of unknown function (DUF4180); Region: DUF4180; pfam13788 358681004288 Uncharacterized conserved protein [Function unknown]; Region: COG1262 358681004289 Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; pfam03781 358681004290 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 358681004291 MarR family; Region: MarR_2; cl17246 358681004292 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 358681004293 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 358681004294 putative substrate translocation pore; other site 358681004295 Domain of unknown function (DUF3817); Region: DUF3817; pfam12823 358681004296 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 358681004297 Major Facilitator Superfamily; Region: MFS_1; pfam07690 358681004298 putative substrate translocation pore; other site 358681004299 SnoaL-like domain; Region: SnoaL_2; pfam12680 358681004300 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643 358681004301 hydrophobic ligand binding site; other site 358681004302 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 358681004303 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 358681004304 Walker A/P-loop; other site 358681004305 ATP binding site [chemical binding]; other site 358681004306 Q-loop/lid; other site 358681004307 ABC transporter signature motif; other site 358681004308 Walker B; other site 358681004309 D-loop; other site 358681004310 H-loop/switch region; other site 358681004311 FtsX-like permease family; Region: FtsX; pfam02687 358681004312 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5294 358681004313 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 358681004314 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 358681004315 active site 358681004316 phosphorylation site [posttranslational modification] 358681004317 intermolecular recognition site; other site 358681004318 dimerization interface [polypeptide binding]; other site 358681004319 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 358681004320 DNA binding site [nucleotide binding] 358681004321 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 358681004322 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 358681004323 dimer interface [polypeptide binding]; other site 358681004324 phosphorylation site [posttranslational modification] 358681004325 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 358681004326 ATP binding site [chemical binding]; other site 358681004327 Mg2+ binding site [ion binding]; other site 358681004328 G-X-G motif; other site 358681004329 VanZ like family; Region: VanZ; cl01971 358681004330 RDD family; Region: RDD; pfam06271 358681004331 Domain of unknown function (DUF4253); Region: DUF4253; pfam14062 358681004332 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cd07812 358681004333 hydrophobic ligand binding site; other site 358681004334 Uncharacterized conserved protein [Function unknown]; Region: COG5646 358681004335 ATP-dependent transcriptional regulator [Transcription]; Region: MalT; COG2909 358681004336 AAA ATPase domain; Region: AAA_16; pfam13191 358681004337 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 358681004338 DNA binding residues [nucleotide binding] 358681004339 dimerization interface [polypeptide binding]; other site 358681004340 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 358681004341 Medium chain dehydrogenases/reductase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR1; cd08267 358681004342 putative NAD(P) binding site [chemical binding]; other site 358681004343 EDD domain protein, DegV family; Region: DegV; TIGR00762 358681004344 Uncharacterized protein, DegV family COG1307; Region: DegV; pfam02645 358681004345 Predicted metal-dependent hydrolase of the TIM-barrel fold [General function prediction only]; Region: COG3618 358681004346 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cd01292 358681004347 active site 358681004348 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 358681004349 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 358681004350 Coenzyme A binding pocket [chemical binding]; other site 358681004351 DEDDh 3'-5' exonuclease domain of Caenorhabditis elegans ERI-1, human 3' exonuclease, and similar proteins; Region: ERI-1_3'hExo_like; cd06133 358681004352 active site 358681004353 substrate binding site [chemical binding]; other site 358681004354 catalytic site [active] 358681004355 Predicted membrane protein [Function unknown]; Region: COG2311 358681004356 Protein of unknown function (DUF418); Region: DUF418; pfam04235 358681004357 S-layer homology domain; Region: SLH; pfam00395 358681004358 S-layer homology domain; Region: SLH; pfam00395 358681004359 S-layer homology domain; Region: SLH; pfam00395 358681004360 TraB family; Region: TraB; pfam01963 358681004361 DoxX-like family; Region: DoxX_2; pfam13564 358681004362 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 358681004363 homoserine O-acetyltransferase; Provisional; Region: metX; cl17114 358681004364 TAP-like protein; Region: Abhydrolase_4; pfam08386 358681004365 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 358681004366 (2R,3R)-2,3-butanediol dehydrogenase; Region: butanediol_DH_like; cd08233 358681004367 putative NAD(P) binding site [chemical binding]; other site 358681004368 catalytic Zn binding site [ion binding]; other site 358681004369 Transcriptional regulators [Transcription]; Region: PurR; COG1609 358681004370 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 358681004371 DNA binding site [nucleotide binding] 358681004372 domain linker motif; other site 358681004373 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 358681004374 ligand binding site [chemical binding]; other site 358681004375 dimerization interface [polypeptide binding]; other site 358681004376 Kynurenine formamidase [Amino acid transport and metabolism]; Region: COG1878 358681004377 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_24; cd09012 358681004378 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 358681004379 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 358681004380 Beta-lactamase; Region: Beta-lactamase; pfam00144 358681004381 S-layer homology domain; Region: SLH; pfam00395 358681004382 S-layer homology domain; Region: SLH; pfam00395 358681004383 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 358681004384 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 358681004385 active site 358681004386 phosphorylation site [posttranslational modification] 358681004387 intermolecular recognition site; other site 358681004388 dimerization interface [polypeptide binding]; other site 358681004389 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 358681004390 DNA binding site [nucleotide binding] 358681004391 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 358681004392 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 358681004393 dimerization interface [polypeptide binding]; other site 358681004394 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 358681004395 dimer interface [polypeptide binding]; other site 358681004396 phosphorylation site [posttranslational modification] 358681004397 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 358681004398 ATP binding site [chemical binding]; other site 358681004399 Mg2+ binding site [ion binding]; other site 358681004400 G-X-G motif; other site 358681004401 Chloramphenicol acetyltransferase; Region: CAT; pfam00302 358681004402 Chloramphenicol O-acetyltransferase [Defense mechanisms]; Region: COG4845 358681004403 Na+/H+ antiporter subunit; Region: PhaG_MnhG_YufB; cl00583 358681004404 ABC-type phosphate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: PstS; COG0226 358681004405 Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416 358681004406 heat shock protein 90; Provisional; Region: PRK05218 358681004407 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 358681004408 ATP binding site [chemical binding]; other site 358681004409 Mg2+ binding site [ion binding]; other site 358681004410 G-X-G motif; other site 358681004411 short chain dehydrogenase; Provisional; Region: PRK06924 358681004412 classical (c) SDRs; Region: SDR_c; cd05233 358681004413 NAD(P) binding site [chemical binding]; other site 358681004414 active site 358681004415 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 358681004416 Helix-Turn-Helix DNA binding domain of the MerR-like transcription regulators YyaN and YraB; Region: HTH_YyaN; cd01109 358681004417 DNA binding residues [nucleotide binding] 358681004418 putative dimer interface [polypeptide binding]; other site 358681004419 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 358681004420 DNA binding residues [nucleotide binding] 358681004421 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 358681004422 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 358681004423 DNA binding residues [nucleotide binding] 358681004424 Adenine deaminase [Nucleotide transport and metabolism]; Region: AdeC; COG1001 358681004425 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 358681004426 Adenine deaminase (AdeC) directly deaminates adenine to form hypoxanthine. This reaction is part of one of the adenine salvage pathways, as well as the degradation pathway. It is important for adenine utilization as a purine, as well as a nitrogen source...; Region: AdeC; cd01295 358681004427 active site 358681004428 Adenine deaminase C-terminal domain; Region: Adenine_deam_C; pfam13382 358681004429 Gamma-aminobutyrate permease and related permeases [Amino acid transport and metabolism]; Region: AnsP; COG1113 358681004430 Spore germination protein; Region: Spore_permease; cl17796 358681004431 ABC-type Mn/Zn transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: ZnuC; COG1121 358681004432 ATP-binding cassette domain of the metal-type transporters; Region: ABC_Metallic_Cations; cd03235 358681004433 ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108 358681004434 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 358681004435 ABC-ATPase subunit interface; other site 358681004436 dimer interface [polypeptide binding]; other site 358681004437 putative PBP binding regions; other site 358681004438 ABC-type metal ion transport system, periplasmic component/surface adhesin [Inorganic ion transport and metabolism]; Region: LraI; COG0803 358681004439 Metal binding protein PsaA. These proteins have been shown to function as initial receptors in ABC transport of Mn2+ and as surface adhesins in some eubacterial species. They belong to the TroA superfamily of periplasmic metal binding proteins that...; Region: PsaA; cd01137 358681004440 metal binding site [ion binding]; metal-binding site 358681004441 hypothetical protein; Provisional; Region: PRK12378 358681004442 Zinc-dependent metalloprotease. This super-family of metalloproteases contains two major branches, the astacin-like proteases and the adamalysin/reprolysin-like proteases. Both branches have wide phylogenetic distribution, and contain sub-families, which...; Region: ZnMc; cl00064 358681004443 active site 358681004444 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 358681004445 Periplasmic binding protein; Region: Peripla_BP_2; pfam01497 358681004446 intersubunit interface [polypeptide binding]; other site 358681004447 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_24; cd09012 358681004448 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 358681004449 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 358681004450 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 358681004451 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 358681004452 Walker A/P-loop; other site 358681004453 ATP binding site [chemical binding]; other site 358681004454 Q-loop/lid; other site 358681004455 ABC transporter signature motif; other site 358681004456 Walker B; other site 358681004457 D-loop; other site 358681004458 H-loop/switch region; other site 358681004459 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 358681004460 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 358681004461 ATP-binding cassette domain of glucan transporter and related proteins, subfamily C; Region: ABCC_Glucan_exporter_like; cd03254 358681004462 Walker A/P-loop; other site 358681004463 ATP binding site [chemical binding]; other site 358681004464 Q-loop/lid; other site 358681004465 ABC transporter signature motif; other site 358681004466 Walker B; other site 358681004467 D-loop; other site 358681004468 H-loop/switch region; other site 358681004469 Methyltransferase domain; Region: Methyltransf_31; pfam13847 358681004470 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 358681004471 S-adenosylmethionine binding site [chemical binding]; other site 358681004472 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 358681004473 flavonol synthase; Region: PLN02997 358681004474 Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330 358681004475 Band_7_prohibitin. A subgroup of the band 7 domain of flotillin (reggie) like proteins. This subgroup group includes proteins similar to prohibitin (a lipid raft-associated integral membrane protein). Individual proteins of this band 7 domain family may...; Region: Band_7_prohibitin; cd03401 358681004476 alkyl hydroperoxide reductase subunit F; Provisional; Region: PRK15317 358681004477 Alkyl hydroperoxide reductase F subunit (AhpF) N-terminal domain (NTD) family, N-terminal TRX-fold subdomain; AhpF is a homodimeric flavoenzyme which catalyzes the NADH-dependent reduction of the peroxiredoxin AhpC, which in turn catalyzes the reduction...; Region: AhpF_NTD_N; cd02974 358681004478 catalytic residue [active] 358681004479 TRX-GRX-like family, Alkyl hydroperoxide reductase F subunit (AhpF) N-terminal domain (NTD) subfamily, C-terminal TRX-fold subdomain; AhpF is a homodimeric flavoenzyme which catalyzes the NADH-dependent reduction of the peroxiredoxin AhpC, which then...; Region: AhpF_NTD_C; cd03026 358681004480 catalytic residues [active] 358681004481 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 358681004482 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 358681004483 peroxiredoxin; Region: AhpC; TIGR03137 358681004484 Peroxiredoxin (PRX) family, Typical 2-Cys PRX subfamily; PRXs are thiol-specific antioxidant (TSA) proteins, which confer a protective role in cells through its peroxidase activity by reducing hydrogen peroxide, peroxynitrite, and organic hydroperoxides; Region: PRX_Typ2cys; cd03015 358681004485 dimer interface [polypeptide binding]; other site 358681004486 decamer (pentamer of dimers) interface [polypeptide binding]; other site 358681004487 catalytic triad [active] 358681004488 peroxidatic and resolving cysteines [active] 358681004489 Uncharacterized conserved protein [Function unknown]; Region: COG3402 358681004490 Predicted membrane protein [Function unknown]; Region: COG3428 358681004491 Bacterial PH domain; Region: DUF304; pfam03703 358681004492 Bacterial PH domain; Region: DUF304; pfam03703 358681004493 Bacterial PH domain; Region: DUF304; pfam03703 358681004494 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 358681004495 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 358681004496 active site 358681004497 metal binding site [ion binding]; metal-binding site 358681004498 Predicted membrane protein [Function unknown]; Region: COG2323 358681004499 S-layer homology domain; Region: SLH; pfam00395 358681004500 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 358681004501 ATP-dependent helicase HrpB; Region: DEAH_box_HrpB; TIGR01970 358681004502 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 358681004503 ATP binding site [chemical binding]; other site 358681004504 putative Mg++ binding site [ion binding]; other site 358681004505 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 358681004506 nucleotide binding region [chemical binding]; other site 358681004507 ATP-binding site [chemical binding]; other site 358681004508 Helicase associated domain (HA2) Add an annotation; Region: HA2; smart00847 358681004509 ATP-dependent helicase C-terminal; Region: HrpB_C; pfam08482 358681004510 Subfamily of the nitroreductase family that includes BluB protein in Rhodobacter capsulatus is involved in the conversion of cobinamide to cobalamin in Cobalamin (vitamin B12) biosynthesis. Nitroreductases typically reduce their substrates by using NAD(P)...; Region: BluB; cd02145 358681004511 putative FMN binding site [chemical binding]; other site 358681004512 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 358681004513 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 358681004514 active site 358681004515 phosphorylation site [posttranslational modification] 358681004516 intermolecular recognition site; other site 358681004517 dimerization interface [polypeptide binding]; other site 358681004518 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 358681004519 DNA binding site [nucleotide binding] 358681004520 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 358681004521 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 358681004522 dimerization interface [polypeptide binding]; other site 358681004523 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 358681004524 dimer interface [polypeptide binding]; other site 358681004525 phosphorylation site [posttranslational modification] 358681004526 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 358681004527 ATP binding site [chemical binding]; other site 358681004528 Mg2+ binding site [ion binding]; other site 358681004529 G-X-G motif; other site 358681004530 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 358681004531 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 358681004532 HlyD family secretion protein; Region: HlyD_3; pfam13437 358681004533 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 358681004534 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 358681004535 Walker A/P-loop; other site 358681004536 ATP binding site [chemical binding]; other site 358681004537 Q-loop/lid; other site 358681004538 ABC transporter signature motif; other site 358681004539 Walker B; other site 358681004540 D-loop; other site 358681004541 H-loop/switch region; other site 358681004542 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 358681004543 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 358681004544 FtsX-like permease family; Region: FtsX; pfam02687 358681004545 Inosine-uridine preferring nucleoside hydrolase; Region: IU_nuc_hydro; pfam01156 358681004546 active site 358681004547 NH_hydro_CaPnhB: A subgroup of nucleoside hydrolases similar to Corynebacterium ammoniagenes Purine/pyrimidine nucleoside hydrolase (pnhB). Nucleoside hydrolases cleave the N-glycosidic bond in nucleosides generating ribose and the respective base. These...; Region: nuc_hydro_CaPnhB; cd02650 358681004548 active site 358681004549 large-conductance mechanosensitive channel; Reviewed; Region: mscL; PRK00567 358681004550 large-conductance mechanosensitive channel; Provisional; Region: mscL; PRK13952 358681004551 YheC/D like ATP-grasp; Region: ATPgrasp_YheCD; pfam14398 358681004552 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 358681004553 Helix-turn-helix domain; Region: HTH_18; pfam12833 358681004554 Uncharacterized protein conserved in bacteria [Function unknown]; Region: MmcQ; COG2315 358681004555 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 358681004556 Mitomycin C resistance protein (MRD); Region: MRD; cd07235 358681004557 dimer interface [polypeptide binding]; other site 358681004558 ligand binding site [chemical binding]; other site 358681004559 FAD binding domain; Region: FAD_binding_4; pfam01565 358681004560 glycolate oxidase, subunit GlcD; Region: glcD; TIGR00387 358681004561 Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247 358681004562 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 358681004563 Cysteine-rich domain; Region: CCG; pfam02754 358681004564 Cysteine-rich domain; Region: CCG; pfam02754 358681004565 Alanine-glyoxylate aminotransferase (AGAT) family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to alanine-glyoxylate aminotransferase (AGAT); Region: AGAT_like; cd06451 358681004566 homodimer interface [polypeptide binding]; other site 358681004567 pyridoxal 5'-phosphate binding site [chemical binding]; other site 358681004568 catalytic residue [active] 358681004569 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; cl00465 358681004570 Domain of unknown function DUF20; Region: UPF0118; pfam01594 358681004571 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 358681004572 Sodium:dicarboxylate symporter family; Region: SDF; cl00573 358681004573 ADP-ribose pyrophosphatase [Nucleotide transport and metabolism]; Region: COG1051 358681004574 nudix motif; other site 358681004575 Uncharacterized conserved protein [General function prediction only]; Region: COG4111 358681004576 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4295 358681004577 Uncharacterized protein conserved in bacteria (DUF2263); Region: DUF2263; pfam10021 358681004578 Macro domain, a high-affinity ADP-ribose binding module found in a variety of proteins as a stand-alone domain or in combination with other domains like in histone macroH2A and some PARPs (poly ADP-ribose polymerases). Some macro domains recognize poly...; Region: Macro; cl00019 358681004579 Nicotinamide mononucleotide transporter; Region: NMN_transporter; pfam04973 358681004580 nicotinamide-nucleotide adenylyltransferase, NadR type; Region: nadR_NMN_Atrans; TIGR01526 358681004581 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 358681004582 active site 358681004583 nucleotide binding site [chemical binding]; other site 358681004584 HIGH motif; other site 358681004585 KMSKS motif; other site 358681004586 Predicted ATPase/kinase involved in NAD metabolism [Coenzyme metabolism]; Region: NadR; COG3172 358681004587 Domain of unknown function (DUF1802); Region: DUF1802; pfam08819 358681004588 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 358681004589 Quinone oxidoreductase (QOR); Region: QOR2; cd05286 358681004590 NADP binding site [chemical binding]; other site 358681004591 dimer interface [polypeptide binding]; other site 358681004592 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 358681004593 Coenzyme A binding pocket [chemical binding]; other site 358681004594 Predicted transcriptional regulator [Transcription]; Region: COG1959 358681004595 Transcriptional regulator; Region: Rrf2; pfam02082 358681004596 Transcriptional regulator; Region: Rrf2; cl17282 358681004597 IDEAL domain; Region: IDEAL; cl07452 358681004598 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 358681004599 catalytic residues [active] 358681004600 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 358681004601 putative substrate translocation pore; other site 358681004602 Major Facilitator Superfamily; Region: MFS_1; pfam07690 358681004603 isoleucyl-tRNA synthetase; Reviewed; Region: ileS; PRK06039 358681004604 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 358681004605 active site 358681004606 HIGH motif; other site 358681004607 nucleotide binding site [chemical binding]; other site 358681004608 catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818 358681004609 active site 358681004610 KMSKS motif; other site 358681004611 Anticodon-binding domain of archaeal, bacterial, and eukaryotic cytoplasmic isoleucyl tRNA synthetases; Region: Anticodon_Ia_Ile_ABEc; cd07961 358681004612 tRNA binding surface [nucleotide binding]; other site 358681004613 anticodon binding site; other site 358681004614 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 358681004615 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 358681004616 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 358681004617 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 358681004618 Predicted membrane protein (DUF2306); Region: DUF2306; pfam10067 358681004619 Transcriptional regulator [Transcription]; Region: LysR; COG0583 358681004620 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 358681004621 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 358681004622 dimerization interface [polypeptide binding]; other site 358681004623 Zn-dependent dipeptidase, microsomal dipeptidase homolog [Amino acid transport and metabolism]; Region: COG2355 358681004624 renal dipeptidase (rDP), best studied in mammals and also called membrane or microsomal dipeptidase, is a membrane-bound glycoprotein hydrolyzing dipeptides and is involved in hydrolytic metabolism of penem and carbapenem beta-lactam antibiotics; Region: rDP_like; cd01301 358681004625 active site 358681004626 dimer interface [polypeptide binding]; other site 358681004627 L-Aminopeptidase D-amidase/D-esterase (DmpA) family; DmpA catalyzes the release of N-terminal D and L amino acids from peptide susbtrates. DmpA is synthesized as a single polypeptide precursor, which is autocatalytically cleaved to the active...; Region: DmpA; cd02253 358681004628 homodimer interface [polypeptide binding]; other site 358681004629 homotetramer interface [polypeptide binding]; other site 358681004630 active site pocket [active] 358681004631 cleavage site 358681004632 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 358681004633 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 358681004634 Beta-lactamase; Region: Beta-lactamase; pfam00144 358681004635 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 358681004636 MarR family; Region: MarR_2; pfam12802 358681004637 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 358681004638 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 358681004639 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 358681004640 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 358681004641 dimer interface [polypeptide binding]; other site 358681004642 conserved gate region; other site 358681004643 putative PBP binding loops; other site 358681004644 ABC-ATPase subunit interface; other site 358681004645 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 358681004646 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 358681004647 dimer interface [polypeptide binding]; other site 358681004648 conserved gate region; other site 358681004649 putative PBP binding loops; other site 358681004650 ABC-ATPase subunit interface; other site 358681004651 Phosphotransferase enzyme family; Region: APH; pfam01636 358681004652 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270 358681004653 active site 358681004654 ATP binding site [chemical binding]; other site 358681004655 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 358681004656 EamA-like transporter family; Region: EamA; pfam00892 358681004657 Solute carrier families 5 and 6-like; solute binding domain; Region: SLC5-6-like_sbd; cl00456 358681004658 Na binding site [ion binding]; other site 358681004659 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 358681004660 Response regulator receiver domain; Region: Response_reg; pfam00072 358681004661 active site 358681004662 phosphorylation site [posttranslational modification] 358681004663 intermolecular recognition site; other site 358681004664 dimerization interface [polypeptide binding]; other site 358681004665 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 358681004666 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 358681004667 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 358681004668 Histidine kinase; Region: His_kinase; pfam06580 358681004669 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 358681004670 ATP binding site [chemical binding]; other site 358681004671 Mg2+ binding site [ion binding]; other site 358681004672 G-X-G motif; other site 358681004673 dipeptide transporter ATP-binding subunit; Provisional; Region: dppF; PRK11308 358681004674 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 358681004675 Walker A/P-loop; other site 358681004676 ATP binding site [chemical binding]; other site 358681004677 Q-loop/lid; other site 358681004678 ABC transporter signature motif; other site 358681004679 Walker B; other site 358681004680 D-loop; other site 358681004681 H-loop/switch region; other site 358681004682 oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727 358681004683 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 358681004684 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 358681004685 Walker A/P-loop; other site 358681004686 ATP binding site [chemical binding]; other site 358681004687 Q-loop/lid; other site 358681004688 ABC transporter signature motif; other site 358681004689 Walker B; other site 358681004690 D-loop; other site 358681004691 H-loop/switch region; other site 358681004692 oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727 358681004693 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 358681004694 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 358681004695 dimer interface [polypeptide binding]; other site 358681004696 conserved gate region; other site 358681004697 putative PBP binding loops; other site 358681004698 ABC-ATPase subunit interface; other site 358681004699 glutathione ABC transporter permease GsiD; Provisional; Region: PRK15082 358681004700 N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911 358681004701 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 358681004702 dimer interface [polypeptide binding]; other site 358681004703 conserved gate region; other site 358681004704 putative PBP binding loops; other site 358681004705 ABC-ATPase subunit interface; other site 358681004706 putative deaminase; Validated; Region: PRK06846 358681004707 Bacterial cytosine deaminase and related metal-dependent hydrolases. Cytosine deaminases (CDs) catalyze the deamination of cytosine, producing uracil and ammonia. They play an important role in pyrimidine salvage. CDs are present in prokaryotes and fungi; Region: Bact_CD; cd01293 358681004708 active site 358681004709 putative deaminase; Validated; Region: PRK06846 358681004710 Bacterial cytosine deaminase and related metal-dependent hydrolases. Cytosine deaminases (CDs) catalyze the deamination of cytosine, producing uracil and ammonia. They play an important role in pyrimidine salvage. CDs are present in prokaryotes and fungi; Region: Bact_CD; cd01293 358681004711 active site 358681004712 putative deaminase; Validated; Region: PRK06846 358681004713 Bacterial cytosine deaminase and related metal-dependent hydrolases. Cytosine deaminases (CDs) catalyze the deamination of cytosine, producing uracil and ammonia. They play an important role in pyrimidine salvage. CDs are present in prokaryotes and fungi; Region: Bact_CD; cd01293 358681004714 active site 358681004715 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 358681004716 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 358681004717 Walker A/P-loop; other site 358681004718 ATP binding site [chemical binding]; other site 358681004719 Q-loop/lid; other site 358681004720 ABC transporter signature motif; other site 358681004721 Walker B; other site 358681004722 D-loop; other site 358681004723 H-loop/switch region; other site 358681004724 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 358681004725 HlyD family secretion protein; Region: HlyD_3; pfam13437 358681004726 FtsX-like permease family; Region: FtsX; pfam02687 358681004727 FtsX-like permease family; Region: FtsX; pfam02687 358681004728 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 358681004729 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 358681004730 Walker A/P-loop; other site 358681004731 ATP binding site [chemical binding]; other site 358681004732 Q-loop/lid; other site 358681004733 ABC transporter signature motif; other site 358681004734 Walker B; other site 358681004735 D-loop; other site 358681004736 H-loop/switch region; other site 358681004737 Transcriptional regulator [Transcription]; Region: LysR; COG0583 358681004738 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 358681004739 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 358681004740 dimerization interface [polypeptide binding]; other site 358681004741 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 358681004742 putative substrate translocation pore; other site 358681004743 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 358681004744 Transcriptional regulator [Transcription]; Region: LysR; COG0583 358681004745 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 358681004746 The substrate binding domain of LysR-type transcriptional regulator GltC, which activates gltA expression of glutamate synthase operon, contains type 2 periplasmic binding fold; Region: PBP2_GltC_like; cd08434 358681004747 putative dimerization interface [polypeptide binding]; other site 358681004748 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 358681004749 putative substrate translocation pore; other site 358681004750 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 358681004751 Integral membrane protein DUF92; Region: DUF92; pfam01940 358681004752 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109 358681004753 Solo B3/4 domain (OB-fold DNA/RNA-binding) of Phe-aaRS-beta [General function prediction only]; Region: COG3382 358681004754 B3/4 domain; Region: B3_4; pfam03483 358681004755 Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280 358681004756 Putative FMN-binding domain; Region: FMN_bind_2; pfam04299 358681004757 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 358681004758 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 358681004759 DNA-binding site [nucleotide binding]; DNA binding site 358681004760 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 358681004761 pyridoxal 5'-phosphate binding site [chemical binding]; other site 358681004762 homodimer interface [polypeptide binding]; other site 358681004763 catalytic residue [active] 358681004764 putative deaminase; Validated; Region: PRK06846 358681004765 Bacterial cytosine deaminase and related metal-dependent hydrolases. Cytosine deaminases (CDs) catalyze the deamination of cytosine, producing uracil and ammonia. They play an important role in pyrimidine salvage. CDs are present in prokaryotes and fungi; Region: Bact_CD; cd01293 358681004766 active site 358681004767 N-ethylammeline chlorohydrolase; Provisional; Region: PRK06151 358681004768 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 358681004769 active site 358681004770 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: PRK12859 358681004771 classical (c) SDRs; Region: SDR_c; cd05233 358681004772 NAD(P) binding site [chemical binding]; other site 358681004773 active site 358681004774 branched-chain amino acid aminotransferase; Provisional; Region: PRK13357 358681004775 BCAT_beta_family: Branched-chain aminotransferase catalyses the transamination of the branched-chain amino acids leusine, isoleucine and valine to their respective alpha-keto acids, alpha-ketoisocaproate, alpha-keto-beta-methylvalerate and...; Region: BCAT_beta_family; cd01557 358681004776 homodimer interface [polypeptide binding]; other site 358681004777 substrate-cofactor binding pocket; other site 358681004778 catalytic residue [active] 358681004779 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 358681004780 DNA-binding site [nucleotide binding]; DNA binding site 358681004781 fatty acid metabolism regulator; Provisional; Region: PRK04984 358681004782 FadR C-terminal domain; Region: FadR_C; pfam07840 358681004783 Fatty acid hydroxylase superfamily; Region: FA_hydroxylase; cl01132 358681004784 The substrate-binding component of an uncharacterized ABC-type peptide import system Ylib contains the type 2 periplasmic binding fold; Region: PBP2_Ylib_like; cd08499 358681004785 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 358681004786 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 358681004787 The substrate-binding component of an uncharacterized ABC-type peptide import system Ylib contains the type 2 periplasmic binding fold; Region: PBP2_Ylib_like; cd08499 358681004788 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 358681004789 The substrate-binding component of an uncharacterized ABC-type peptide import system Ylib contains the type 2 periplasmic binding fold; Region: PBP2_Ylib_like; cd08499 358681004790 putative deaminase; Validated; Region: PRK06846 358681004791 Bacterial cytosine deaminase and related metal-dependent hydrolases. Cytosine deaminases (CDs) catalyze the deamination of cytosine, producing uracil and ammonia. They play an important role in pyrimidine salvage. CDs are present in prokaryotes and fungi; Region: Bact_CD; cd01293 358681004792 active site 358681004793 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 358681004794 The substrate-binding component of an uncharacterized ABC-type peptide import system Ylib contains the type 2 periplasmic binding fold; Region: PBP2_Ylib_like; cd08499 358681004795 isopentenyl-diphosphate delta-isomerase, type 1; Region: IPP_isom_1; TIGR02150 358681004796 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_33; cd04692 358681004797 nudix motif; other site 358681004798 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 358681004799 Major Facilitator Superfamily; Region: MFS_1; pfam07690 358681004800 putative substrate translocation pore; other site 358681004801 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 358681004802 Acetyltransferase (GNAT) domain; Region: Acetyltransf_9; pfam13527 358681004803 Sterol carrier protein domain; Region: SCP2_2; pfam13530 358681004804 PilZ domain; Region: PilZ; pfam07238 358681004805 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cl17315 358681004806 Uncharacterized protein conserved in bacteria (DUF2087); Region: DUF2087; pfam09860 358681004807 GIY-YIG domain of LuxR and ArsR family transcriptional regulators, and uncharacterized hypothetical proteins found in bacteria; Region: GIY-YIG_LuxR_like; cd10451 358681004808 GIY-YIG motif/motif A; other site 358681004809 Spore coat protein (Spore_GerQ); Region: Spore_GerQ; pfam09671 358681004810 Cell Wall Hydrolase; Region: Hydrolase_2; pfam07486 358681004811 Helix-Turn-Helix DNA binding domain of the regulatory protein GnyR; Region: HTH_GnyR; cd04776 358681004812 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 358681004813 DNA binding residues [nucleotide binding] 358681004814 putative dimer interface [polypeptide binding]; other site 358681004815 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK06187 358681004816 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 358681004817 Bacterial Bile acid CoA ligases and similar proteins; Region: BACL_like; cd05929 358681004818 acyl-activating enzyme (AAE) consensus motif; other site 358681004819 putative AMP binding site [chemical binding]; other site 358681004820 putative active site [active] 358681004821 putative CoA binding site [chemical binding]; other site 358681004822 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 358681004823 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 358681004824 active site 358681004825 Predicted membrane protein [Function unknown]; Region: COG1238 358681004826 menaquinone biosynthesis protein, SCO4550 family; Region: mena_SCO4550; TIGR03699 358681004827 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 358681004828 FeS/SAM binding site; other site 358681004829 YtxC-like family; Region: YtxC; pfam08812 358681004830 threonyl-tRNA synthetase; Reviewed; Region: PRK12444 358681004831 TGS _ThrRS_N: ThrRS (threonyl-tRNA Synthetase) is a class II tRNA synthetase that couples threonine to its cognate tRNA. In addition to its catalytic and anticodon-binding domains, ThrRS has an N-terminal TGS domain, named after the ThrRS, GTPase, and...; Region: TGS_ThrRS_N; cd01667 358681004832 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863 358681004833 Threonyl-tRNA synthetase (ThrRS) class II core catalytic domain. ThrRS is a homodimer. It is responsible for the attachment of threonine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ThrRS_core; cd00771 358681004834 active site 358681004835 dimer interface [polypeptide binding]; other site 358681004836 motif 1; other site 358681004837 motif 2; other site 358681004838 motif 3; other site 358681004839 ThrRS Threonyl-anticodon binding domain. ThrRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: ThrRS_anticodon; cd00860 358681004840 anticodon binding site; other site 358681004841 Cache domain; Region: Cache_1; pfam02743 358681004842 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 358681004843 dimerization interface [polypeptide binding]; other site 358681004844 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 358681004845 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 358681004846 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 358681004847 dimer interface [polypeptide binding]; other site 358681004848 putative CheW interface [polypeptide binding]; other site 358681004849 molybdenum cofactor biosynthesis protein A; Reviewed; Region: moaA; PRK00164 358681004850 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 358681004851 FeS/SAM binding site; other site 358681004852 Molybdenum Cofactor Synthesis C; Region: Mob_synth_C; pfam06463 358681004853 translation initiation factor IF-3; Reviewed; Region: infC; PRK00028 358681004854 Translation initiation factor IF-3, N-terminal domain; Region: IF3_N; pfam05198 358681004855 Translation initiation factor IF-3, C-terminal domain; Region: IF3_C; pfam00707 358681004856 50S ribosomal protein L35; Reviewed; Region: rpmI; PRK00172 358681004857 Ribosomal protein L20; Region: Ribosomal_L20; cd07026 358681004858 23S rRNA binding site [nucleotide binding]; other site 358681004859 L21 binding site [polypeptide binding]; other site 358681004860 L13 binding site [polypeptide binding]; other site 358681004861 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 358681004862 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 358681004863 DNA binding residues [nucleotide binding] 358681004864 dimerization interface [polypeptide binding]; other site 358681004865 Ribonucleotide Reductase R2-like protein, Mn/Fe-binding domain; Region: RNRR2_Rv0233_like; cd07911 358681004866 active site 358681004867 diiron metal binding site [ion binding]; other site 358681004868 3'-phosphoadenosine 5'-phosphosulfate sulfotransferase (PAPS reductase)/FAD synthetase and related enzymes [Amino acid transport and metabolism / Coenzyme metabolism]; Region: CysH; COG0175 358681004869 This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713 358681004870 Active Sites [active] 358681004871 ATP sulphurylase; Region: sopT; TIGR00339 358681004872 ATP-sulfurylase; Region: ATPS; cd00517 358681004873 active site 358681004874 HXXH motif; other site 358681004875 flexible loop; other site 358681004876 acetolactate synthase catalytic subunit; Reviewed; Region: PRK07710 358681004877 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 358681004878 PYR/PP interface [polypeptide binding]; other site 358681004879 dimer interface [polypeptide binding]; other site 358681004880 TPP binding site [chemical binding]; other site 358681004881 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 358681004882 Thiamine pyrophosphate (TPP) family, Acetohydroxyacid synthase (AHAS) subfamily, TPP-binding module; composed of proteins similar to the large catalytic subunit of AHAS. AHAS catalyzes the condensation of two molecules of pyruvate to give the...; Region: TPP_AHAS; cd02015 358681004883 TPP-binding site [chemical binding]; other site 358681004884 dimer interface [polypeptide binding]; other site 358681004885 acetolactate synthase 3 regulatory subunit; Reviewed; Region: ilvH; PRK11895 358681004886 N-terminal ACT domain of the Escherichia coli IlvH-like regulatory subunit of acetohydroxyacid synthase (AHAS); Region: ACT_AHAS; cd04878 358681004887 putative valine binding site [chemical binding]; other site 358681004888 dimer interface [polypeptide binding]; other site 358681004889 Small subunit of acetolactate synthase; Region: ALS_ss_C; pfam10369 358681004890 ketol-acid reductoisomerase; Provisional; Region: PRK05479 358681004891 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvN; pfam07991 358681004892 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvC; pfam01450 358681004893 2-isopropylmalate synthase; Validated; Region: PRK00915 358681004894 2-isopropylmalate synthase (IPMS), N-terminal catalytic TIM barrel domain; Region: DRE_TIM_IPMS; cd07940 358681004895 active site 358681004896 catalytic residues [active] 358681004897 metal binding site [ion binding]; metal-binding site 358681004898 LeuA allosteric (dimerisation) domain; Region: LeuA_dimer; pfam08502 358681004899 tartrate dehydrogenase; Region: TTC; TIGR02089 358681004900 3-isopropylmalate dehydrogenase; Provisional; Region: PRK00772 358681004901 potassium uptake protein, TrkH family; Region: 2a38; TIGR00933 358681004902 Trk-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: TrkG; COG0168 358681004903 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 358681004904 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 358681004905 DNA-binding site [nucleotide binding]; DNA binding site 358681004906 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 358681004907 pyridoxal 5'-phosphate binding site [chemical binding]; other site 358681004908 homodimer interface [polypeptide binding]; other site 358681004909 catalytic residue [active] 358681004910 MogA_MoaB family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF) an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea; Region: MogA_MoaB; cd00886 358681004911 MPT binding site; other site 358681004912 trimer interface [polypeptide binding]; other site 358681004913 B12 binding domain_like associated with radical SAM domain. This domain shows similarity with B12 (adenosylcobamide) binding domains found in several enzymes, such as glutamate mutase, methionine synthase and methylmalonyl-CoA mutase, but it lacks the...; Region: radical_SAM_B12_BD; cd02068 358681004914 Radical SAM superfamily; Region: Radical_SAM; pfam04055 358681004915 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cl15377 358681004916 FeS/SAM binding site; other site 358681004917 Protein of unknown function (DUF4080); Region: DUF4080; pfam13311 358681004918 DNA alkylation repair enzyme; Region: DNA_alkylation; pfam08713 358681004919 A new structural DNA glycosylase containing HEAT-like repeats; Region: AlkD_like_1; cd07064 358681004920 active site 358681004921 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 358681004922 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 358681004923 Protein of unknown function (DUF1294); Region: DUF1294; pfam06961 358681004924 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 358681004925 kynureninase; Region: kynureninase; TIGR01814 358681004926 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 358681004927 catalytic residue [active] 358681004928 Bacillus/Clostridium GerA spore germination protein; Region: GerA; pfam03323 358681004929 Spore germination protein; Region: Spore_permease; cl17796 358681004930 germination protein, Ger(x)C family; Region: spore_ger_x_C; TIGR02887 358681004931 Spore germination B3/ GerAC like, C-terminal; Region: Spore_GerAC; pfam05504 358681004932 Spore germination protein; Region: Spore_permease; cl17796 358681004933 small acid-soluble spore protein SspI; Provisional; Region: PRK02955 358681004934 K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569 358681004935 TrkA-N domain; Region: TrkA_N; pfam02254 358681004936 TrkA-C domain; Region: TrkA_C; pfam02080 358681004937 rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566 358681004938 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; smart00967 358681004939 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 358681004940 Uncharacterized protein conserved in bacteria (DUF2225); Region: DUF2225; pfam09986 358681004941 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 358681004942 binding surface 358681004943 TPR motif; other site 358681004944 phenylalanyl-tRNA synthetase subunit alpha; Validated; Region: pheS; PRK00488 358681004945 Aminoacyl tRNA synthetase class II, N-terminal domain; Region: Phe_tRNA-synt_N; pfam02912 358681004946 Phenylalanyl-tRNA synthetase (PheRS) alpha chain catalytic core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs. This domain is primarily responsible...; Region: PheRS_alpha_core; cd00496 358681004947 dimer interface [polypeptide binding]; other site 358681004948 motif 1; other site 358681004949 active site 358681004950 motif 2; other site 358681004951 motif 3; other site 358681004952 phenylalanyl-tRNA synthetase subunit beta; Reviewed; Region: pheT; PRK00629 358681004953 tRNA-binding-domain-containing prokaryotic phenylalanly tRNA synthetase (PheRS) beta chain. PheRS aminoacylate phenylalanine transfer RNAs (tRNAphe). PheRSs belong structurally to class II aminoacyl tRNA synthetases (aaRSs) but, as they aminoacylate...; Region: tRNA_bind_bactPheRS; cd02796 358681004954 putative tRNA-binding site [nucleotide binding]; other site 358681004955 B3/4 domain; Region: B3_4; pfam03483 358681004956 tRNA synthetase B5 domain; Region: B5; smart00874 358681004957 Phenylalanyl-tRNA synthetase (PheRS) beta chain core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure. While class II aaRSs generally aminoacylate the 3'-OH ribose of the appropriate tRNA, PheRS is an...; Region: PheRS_beta_core; cd00769 358681004958 dimer interface [polypeptide binding]; other site 358681004959 motif 1; other site 358681004960 motif 3; other site 358681004961 motif 2; other site 358681004962 Ferredoxin-fold anticodon binding domain; Region: FDX-ACB; pfam03147 358681004963 Cell division protein ZapA; Region: ZapA; cl01146 358681004964 Membrane protein of unknown function; Region: DUF360; pfam04020 358681004965 recombination and DNA strand exchange inhibitor protein; Reviewed; Region: PRK00409 358681004966 MutS domain III; Region: MutS_III; pfam05192 358681004967 ATP-binding cassette domain of MutS2; Region: ABC_MutS2; cd03280 358681004968 Walker A/P-loop; other site 358681004969 ATP binding site [chemical binding]; other site 358681004970 Q-loop/lid; other site 358681004971 ABC transporter signature motif; other site 358681004972 Walker B; other site 358681004973 D-loop; other site 358681004974 H-loop/switch region; other site 358681004975 Smr domain; Region: Smr; pfam01713 358681004976 Predicted membrane protein [Function unknown]; Region: COG3766 358681004977 Domain of Unknown Function (DUF350); Region: DUF350; pfam03994 358681004978 Domain of Unknown Function (DUF350); Region: DUF350; pfam03994 358681004979 UDP-N-acetyl-D-mannosaminuronate dehydrogenase [Cell envelope biogenesis, outer membrane]; Region: WecC; COG0677 358681004980 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210 358681004981 UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984 358681004982 UDP binding domain; Region: UDPG_MGDP_dh_C; smart00984 358681004983 RNA polymerase sigma factor; Provisional; Region: PRK12543 358681004984 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 358681004985 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cl17257 358681004986 Domain of unknown function (DUF4179); Region: DUF4179; pfam13786 358681004987 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 358681004988 DNA-binding site [nucleotide binding]; DNA binding site 358681004989 RNA-binding motif; other site 358681004990 Peptidase M55, D-aminopeptidase dipeptide-binding protein family; Region: DAP_dppA_1; cd08663 358681004991 SxDxEG motif; other site 358681004992 active site 358681004993 metal binding site [ion binding]; metal-binding site 358681004994 homopentamer interface [polypeptide binding]; other site 358681004995 This family is most closely related to the GT1 family of glycosyltransferases. WbnK in Shigella dysenteriae has been shown to be involved in the type 7 O-antigen biosynthesis; Region: GT1_WbnK_like; cd03807 358681004996 sugar transferase, PEP-CTERM/EpsH1 system associated; Region: stp2; TIGR03088 358681004997 putative ADP-binding pocket [chemical binding]; other site 358681004998 This family is most closely related to the GT1 family of glycosyltransferases. wbuB in E. coli is involved in the biosynthesis of the O26 O-antigen. It has been proposed to function as an N-acetyl-L-fucosamine (L-FucNAc) transferase; Region: GT1_wbuB_like; cd03794 358681004999 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 358681005000 O-Antigen ligase; Region: Wzy_C; cl04850 358681005001 Uncharacterized membrane protein, putative virulence factor [General function prediction only]; Region: MviN; COG0728 358681005002 MurJ/MviN, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_MurJ_like; cd13123 358681005003 Coenzyme F390 synthetase [Coenzyme metabolism]; Region: PaaK; COG1541 358681005004 putative adenylate-forming enzyme; Region: aden_form_hyp; TIGR02304 358681005005 Stage V sporulation protein B, also known as Stage III sporulation protein F, and related proteins; Region: MATE_SpoVB_like; cd13124 358681005006 stage V sporulation protein B; Region: spore_V_B; TIGR02900 358681005007 Methyltransferase domain; Region: Methyltransf_23; pfam13489 358681005008 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 358681005009 S-adenosylmethionine binding site [chemical binding]; other site 358681005010 polysaccharide pyruvyl transferase CsaB; Region: S_layer_CsaB; TIGR03609 358681005011 ribosomal protein L11 methyltransferase; Reviewed; Region: prmA; PRK00517 358681005012 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 358681005013 S-adenosylmethionine binding site [chemical binding]; other site 358681005014 putative acyltransferase; Provisional; Region: PRK05790 358681005015 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 358681005016 dimer interface [polypeptide binding]; other site 358681005017 active site 358681005018 Transcriptional regulator [Transcription]; Region: LytR; COG1316 358681005019 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK06710 358681005020 Prokaryotic long-chain fatty acid CoA synthetases similar to Escherichia coli FadD; Region: FC-FACS_FadD_like; cd05936 358681005021 acyl-activating enzyme (AAE) consensus motif; other site 358681005022 putative AMP binding site [chemical binding]; other site 358681005023 putative active site [active] 358681005024 putative CoA binding site [chemical binding]; other site 358681005025 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 358681005026 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 358681005027 YsiA-like protein, C-terminal region; Region: TetR_C_4; pfam08359 358681005028 enoyl-CoA hydratase; Provisional; Region: PRK07658 358681005029 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 358681005030 substrate binding site [chemical binding]; other site 358681005031 oxyanion hole (OAH) forming residues; other site 358681005032 trimer interface [polypeptide binding]; other site 358681005033 The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_beta; cd01714 358681005034 Ligand binding site [chemical binding]; other site 358681005035 Electron transfer flavoprotein domain; Region: ETF; pfam01012 358681005036 Electron transfer flavoprotein, alpha subunit [Energy production and conversion]; Region: FixB; COG2025 358681005037 The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_alpha; cd01715 358681005038 Electron transfer flavoprotein FAD-binding domain; Region: ETF_alpha; pfam00766 358681005039 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 358681005040 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 358681005041 catalytic residues [active] 358681005042 ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683 358681005043 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 358681005044 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 358681005045 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 358681005046 TM-ABC transporter signature motif; other site 358681005047 ABC-type branched-chain amino acid transport system, permease component [Amino acid transport and metabolism]; Region: LivM; COG4177 358681005048 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 358681005049 TM-ABC transporter signature motif; other site 358681005050 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411 358681005051 ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219 358681005052 Walker A/P-loop; other site 358681005053 ATP binding site [chemical binding]; other site 358681005054 Q-loop/lid; other site 358681005055 ABC transporter signature motif; other site 358681005056 Walker B; other site 358681005057 D-loop; other site 358681005058 H-loop/switch region; other site 358681005059 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410 358681005060 ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224 358681005061 Walker A/P-loop; other site 358681005062 ATP binding site [chemical binding]; other site 358681005063 Q-loop/lid; other site 358681005064 ABC transporter signature motif; other site 358681005065 Walker B; other site 358681005066 D-loop; other site 358681005067 H-loop/switch region; other site 358681005068 Uncharacterized conserved protein (DUF2164); Region: DUF2164; pfam09932 358681005069 excinuclease ABC subunit C; Validated; Region: uvrC; PRK00558 358681005070 Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434 358681005071 GIY-YIG motif/motif A; other site 358681005072 active site 358681005073 catalytic site [active] 358681005074 putative DNA binding site [nucleotide binding]; other site 358681005075 metal binding site [ion binding]; metal-binding site 358681005076 UvrB/uvrC motif; Region: UVR; pfam02151 358681005077 UvrC Helix-hairpin-helix N-terminal; Region: UvrC_HhH_N; pfam08459 358681005078 aspartate kinase; Reviewed; Region: PRK06635 358681005079 AAK_AKii-LysC-BS: Amino Acid Kinase Superfamily (AAK), AKii; this CD includes the N-terminal catalytic aspartokinase (AK) domain of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis 168, and the lysine plus threonine-sensitive...; Region: AAK_AKii-LysC-BS; cd04261 358681005080 putative nucleotide binding site [chemical binding]; other site 358681005081 putative catalytic residues [active] 358681005082 putative Mg ion binding site [ion binding]; other site 358681005083 putative aspartate binding site [chemical binding]; other site 358681005084 ACT domains of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related proteins; Region: ACT_AKii-LysC-BS-like_1; cd04913 358681005085 putative allosteric regulatory site; other site 358681005086 ACT domains of the lysine-sensitive, aspartokinase (AK) isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related domains; Region: ACT_AKii-LysC-BS-like_2; cd04936 358681005087 putative allosteric regulatory residue; other site 358681005088 Protein of unknown function (DUF2507); Region: DUF2507; pfam10702 358681005089 Succinate:quinone oxidoreductase (SQR) Type B subfamily 1, transmembrane subunit; composed of proteins similar to Bacillus subtilis SQR. SQR catalyzes the oxidation of succinate to fumarate coupled to the reduction of quinone to quinol. Bacillus subtilis...; Region: SQR_TypeB_1_TM; cd03497 358681005090 proximal heme binding site [chemical binding]; other site 358681005091 putative dimer interface [polypeptide binding]; other site 358681005092 putative Iron-sulfur protein interface [polypeptide binding]; other site 358681005093 distal heme binding site [chemical binding]; other site 358681005094 succinate dehydrogenase flavoprotein subunit; Reviewed; Region: sdhA; PRK08641 358681005095 L-aspartate oxidase; Provisional; Region: PRK06175 358681005096 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 358681005097 succinate dehydrogenase iron-sulfur subunit; Reviewed; Region: sdhB; PRK08640 358681005098 2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_3; pfam13085 358681005099 MarR family; Region: MarR_2; pfam12802 358681005100 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 358681005101 Peptidase S8 family domain in Streptococcal C5a peptidases; Region: Peptidases_S8_C5a_Peptidase; cd07475 358681005102 putative active site [active] 358681005103 catalytic triad [active] 358681005104 PA_C5a_like: Protease-associated domain containing proteins like Streptococcus pyogenes C5a peptidase. This group contains various PA domain-containing proteins similar to S. pyogenes C5a, including, i) Vpr, a minor extracellular serine protease from...; Region: PA_C5a_like; cd02133 358681005105 PA/protease domain interface [polypeptide binding]; other site 358681005106 putative integrin binding motif; other site 358681005107 Peptidase S8 family domain in Streptococcal C5a peptidases; Region: Peptidases_S8_C5a_Peptidase; cd07475 358681005108 Fn3-like domain (DUF1034); Region: DUF1034; pfam06280 358681005109 Predicted inhibitor of MCP methylation, homolog of CheC [Cell motility and secretion]; Region: COG1406 358681005110 Chemotaxis phosphatase CheX; Region: CheX; pfam13690 358681005111 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 358681005112 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 358681005113 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 358681005114 Walker A/P-loop; other site 358681005115 ATP binding site [chemical binding]; other site 358681005116 Q-loop/lid; other site 358681005117 ABC transporter signature motif; other site 358681005118 Walker B; other site 358681005119 D-loop; other site 358681005120 H-loop/switch region; other site 358681005121 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 358681005122 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 358681005123 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 358681005124 dimer interface [polypeptide binding]; other site 358681005125 conserved gate region; other site 358681005126 putative PBP binding loops; other site 358681005127 ABC-ATPase subunit interface; other site 358681005128 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 358681005129 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 358681005130 dimer interface [polypeptide binding]; other site 358681005131 conserved gate region; other site 358681005132 putative PBP binding loops; other site 358681005133 ABC-ATPase subunit interface; other site 358681005134 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 358681005135 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 358681005136 DNA binding residues [nucleotide binding] 358681005137 dimerization interface [polypeptide binding]; other site 358681005138 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 358681005139 Coenzyme A binding pocket [chemical binding]; other site 358681005140 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_5; cd07238 358681005141 dimer interface [polypeptide binding]; other site 358681005142 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 358681005143 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 358681005144 Peptidase family M23; Region: Peptidase_M23; pfam01551 358681005145 Chitinase [Carbohydrate transport and metabolism]; Region: ChiA; COG3325 358681005146 The GH18 (glycosyl hydrolases, family 18) type II chitinases hydrolyze chitin, an abundant polymer of N-acetylglucosamine and have been identified in bacteria, fungi, insects, plants, viruses, and protozoan parasites. The structure of this domain is an...; Region: GH18_chitinase; cd06548 358681005147 active site 358681005148 Uncharacterized protein contain chitin-binding domain type 3 [General function prediction only]; Region: COG3979 358681005149 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 358681005150 Interdomain contacts; other site 358681005151 Cytokine receptor motif; other site 358681005152 Uncharacterized protein contain chitin-binding domain type 3 [General function prediction only]; Region: COG3979 358681005153 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 358681005154 Interdomain contacts; other site 358681005155 Cytokine receptor motif; other site 358681005156 chitin-binding domain of Chi A1-like proteins; Region: ChiA1_BD; cd12214 358681005157 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 358681005158 putative switch regulator; other site 358681005159 non-specific DNA interactions [nucleotide binding]; other site 358681005160 DNA binding site [nucleotide binding] 358681005161 sequence specific DNA binding site [nucleotide binding]; other site 358681005162 putative cAMP binding site [chemical binding]; other site 358681005163 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 358681005164 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 358681005165 nucleotide binding site [chemical binding]; other site 358681005166 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 358681005167 PBP superfamily domain; Region: PBP_like_2; cl17296 358681005168 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 358681005169 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 358681005170 dimer interface [polypeptide binding]; other site 358681005171 conserved gate region; other site 358681005172 putative PBP binding loops; other site 358681005173 ABC-ATPase subunit interface; other site 358681005174 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 358681005175 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 358681005176 dimer interface [polypeptide binding]; other site 358681005177 conserved gate region; other site 358681005178 putative PBP binding loops; other site 358681005179 ABC-ATPase subunit interface; other site 358681005180 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 358681005181 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 358681005182 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 358681005183 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 358681005184 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 358681005185 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 358681005186 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 358681005187 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 358681005188 Putative oxidoreductase C terminal; Region: ox_reductase_C; pfam08635 358681005189 Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261 358681005190 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cl12060 358681005191 Metal-binding active site; metal-binding site 358681005192 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 358681005193 ROK family; Region: ROK; pfam00480 358681005194 nucleotide binding site [chemical binding]; other site 358681005195 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 358681005196 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 358681005197 dimer interface [polypeptide binding]; other site 358681005198 pyridoxal 5'-phosphate binding site [chemical binding]; other site 358681005199 catalytic residue [active] 358681005200 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 358681005201 hypothetical protein; Provisional; Region: PRK06753 358681005202 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 358681005203 M20 Peptidase Aminoacylase 1 family; Region: M20_Acy1; cd03886 358681005204 metal binding site [ion binding]; metal-binding site 358681005205 dimer interface [polypeptide binding]; other site 358681005206 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 358681005207 ATP binding site [chemical binding]; other site 358681005208 Mg2+ binding site [ion binding]; other site 358681005209 G-X-G motif; other site 358681005210 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 358681005211 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 358681005212 putative substrate translocation pore; other site 358681005213 Predicted transcriptional regulators [Transcription]; Region: COG1378 358681005214 Sugar-specific transcriptional regulator TrmB; Region: TrmB; pfam01978 358681005215 Middle phospholipase D-like domain of the transcriptional regulator TrmB and similar proteins; Region: PLDc_like_TrmB_middle; cd09124 358681005216 C-terminal domain interface [polypeptide binding]; other site 358681005217 sugar binding site [chemical binding]; other site 358681005218 Immune inhibitor A peptidase M6; Region: Peptidase_M6; cl11525 358681005219 The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_beta; cd01714 358681005220 Ligand binding site [chemical binding]; other site 358681005221 Electron transfer flavoprotein domain; Region: ETF; pfam01012 358681005222 Electron transfer flavoprotein, alpha subunit [Energy production and conversion]; Region: FixB; COG2025 358681005223 The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_alpha; cd01715 358681005224 Electron transfer flavoprotein FAD-binding domain; Region: ETF_alpha; pfam00766 358681005225 oxidoreductase; Provisional; Region: PRK10015 358681005226 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 358681005227 Ferredoxin-like protein [Energy production and conversion]; Region: FixX; COG2440 358681005228 Mpr1p, Pad1p N-terminal (MPN) domains with catalytic isopeptidase activity (metal-binding); Region: MPN_like; cd08070 358681005229 MPN+ (JAMM) motif; other site 358681005230 Zinc-binding site [ion binding]; other site 358681005231 Chromosome segregation ATPases [Cell division and chromosome partitioning]; Region: Smc; COG1196 358681005232 Chromosome segregation ATPases [Cell division and chromosome partitioning]; Region: Smc; COG1196 358681005233 phosphodiesterase; Provisional; Region: PRK12704 358681005234 Chromosome segregation ATPases [Cell division and chromosome partitioning]; Region: Smc; COG1196 358681005235 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 358681005236 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 358681005237 active site 358681005238 Putative peptidoglycan-binding domain-containing protein [Cell envelope biogenesis, outer membrane]; Region: COG3409 358681005239 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 358681005240 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 358681005241 Uncharacterized protein with SCP/PR1 domains [Function unknown]; Region: COG2340 358681005242 SCP_bacterial: SCP-like extracellular protein domain, as found in bacteria and archaea. The wider family of SCP containing proteins includes plant pathogenesis-related protein 1 (PR-1), CRISPs, mammalian cysteine-rich secretory proteins, and allergen 5...; Region: SCP_bacterial; cd05379 358681005243 Protein of unknown function (DUF1360); Region: DUF1360; pfam07098 358681005244 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 358681005245 WfgS and WfeV are involved in O-antigen biosynthesis; Region: GT_2_WfgS_like; cd06433 358681005246 metal-binding site 358681005247 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 358681005248 S-adenosylmethionine binding site [chemical binding]; other site 358681005249 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 358681005250 mannose-1-phosphate guanylyltransferase/mannose-6-phosphate isomerase; Region: GMP_PMI; TIGR01479 358681005251 active site 358681005252 Cupin domain; Region: Cupin_2; cl17218 358681005253 CDP-glucose 4,6-dehydratase; Region: CDP_4_6_dhtase; TIGR02622 358681005254 CDP-D-glucose 4,6-dehydratase, extended (e) SDRs; Region: CDP_GD_SDR_e; cd05252 358681005255 NAD binding site [chemical binding]; other site 358681005256 homotetramer interface [polypeptide binding]; other site 358681005257 homodimer interface [polypeptide binding]; other site 358681005258 substrate binding site [chemical binding]; other site 358681005259 active site 358681005260 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis/translation initiation factor 2B, gamma/epsilon subunits (eIF-2Bgamma/eIF-2Bepsilon) [Cell envelope biogenesis, outer membrane / Translation, ribosomal structure...; Region: GCD1; COG1208 358681005261 G1P_cytidylyltransferase catalyzes the production of CDP-D-Glucose; Region: G1P_cytidylyltransferase; cd02524 358681005262 substrate binding site; other site 358681005263 methyltransferase, FkbM family; Region: fkbM_fam; TIGR01444 358681005264 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 358681005265 NAD dependent epimerase/dehydratase family; Region: Epimerase; pfam01370 358681005266 NAD(P) binding site [chemical binding]; other site 358681005267 active site 358681005268 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 358681005269 methyltransferase, FkbM family; Region: fkbM_fam; TIGR01444 358681005270 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 358681005271 This family is most closely related to the GT1 family of glycosyltransferases. mtfB (mannosyltransferase B) in E. coli has been shown to direct the growth of the O9-specific polysaccharide chain. It transfers two mannoses into the position 3 of the...; Region: GT1_mtfB_like; cd03809 358681005272 GDP-fucose synthetase, extended (e) SDRs; Region: GDP_FS_SDR_e; cd05239 358681005273 GDP-4-keto-6-deoxymannose-3, 5-epimerase-4-reductase; Region: PLN02725 358681005274 NADP binding site [chemical binding]; other site 358681005275 active site 358681005276 putative substrate binding site [chemical binding]; other site 358681005277 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 358681005278 WfgS and WfeV are involved in O-antigen biosynthesis; Region: GT_2_WfgS_like; cd06433 358681005279 metal-binding site 358681005280 GDP-mannose 4,6 dehydratase, extended (e) SDRs; Region: GDP_MD_SDR_e; cd05260 358681005281 GDP-D-mannose dehydratase [Cell envelope biogenesis, outer membrane]; Region: Gmd; COG1089 358681005282 NADP-binding site; other site 358681005283 homotetramer interface [polypeptide binding]; other site 358681005284 substrate binding site [chemical binding]; other site 358681005285 homodimer interface [polypeptide binding]; other site 358681005286 active site 358681005287 phosphoglucomutase-2-like protein; Provisional; Region: PTZ00150 358681005288 This CD includes PGM2 (phosphoglucomutase 2) and PGM2L1 (phosphoglucomutase 2-like 1). The mammalian PGM2 is thought to be a phosphopentomutase that catalyzes the conversion of the nucleoside breakdown products, ribose-1-phosphate and...; Region: PGM2; cd05799 358681005289 active site 358681005290 substrate binding site [chemical binding]; other site 358681005291 metal binding site [ion binding]; metal-binding site 358681005292 GDP-D-mannose dehydratase [Cell envelope biogenesis, outer membrane]; Region: Gmd; COG1089 358681005293 GDP-mannose 4,6 dehydratase, extended (e) SDRs; Region: GDP_MD_SDR_e; cd05260 358681005294 NADP-binding site; other site 358681005295 homotetramer interface [polypeptide binding]; other site 358681005296 substrate binding site [chemical binding]; other site 358681005297 homodimer interface [polypeptide binding]; other site 358681005298 active site 358681005299 L-asparaginase II; Region: Asparaginase_II; pfam06089 358681005300 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 358681005301 The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504 358681005302 peptide binding site [polypeptide binding]; other site 358681005303 Transcriptional regulator containing PAS, AAA-type ATPase, and DNA-binding domains [Transcription / Signal transduction mechanisms]; Region: RocR; COG3829 358681005304 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 358681005305 Walker B motif; other site 358681005306 arginine finger; other site 358681005307 dipeptidase PepV; Reviewed; Region: PRK07318 358681005308 M20 Peptidase Xaa-His dipeptidase (PepV) degrades hydrophobic dipeptides; Region: M20_PepV; cd03888 358681005309 active site 358681005310 metal binding site [ion binding]; metal-binding site 358681005311 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 358681005312 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 358681005313 dimer interface [polypeptide binding]; other site 358681005314 conserved gate region; other site 358681005315 putative PBP binding loops; other site 358681005316 ABC-ATPase subunit interface; other site 358681005317 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 358681005318 N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911 358681005319 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 358681005320 dimer interface [polypeptide binding]; other site 358681005321 conserved gate region; other site 358681005322 putative PBP binding loops; other site 358681005323 ABC-ATPase subunit interface; other site 358681005324 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 358681005325 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 358681005326 Walker A/P-loop; other site 358681005327 ATP binding site [chemical binding]; other site 358681005328 Q-loop/lid; other site 358681005329 ABC transporter signature motif; other site 358681005330 Walker B; other site 358681005331 D-loop; other site 358681005332 H-loop/switch region; other site 358681005333 oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727 358681005334 ABC-type oligopeptide transport system, ATPase component [Amino acid transport and metabolism]; Region: AppF; COG4608 358681005335 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 358681005336 Walker A/P-loop; other site 358681005337 ATP binding site [chemical binding]; other site 358681005338 Q-loop/lid; other site 358681005339 ABC transporter signature motif; other site 358681005340 Walker B; other site 358681005341 D-loop; other site 358681005342 H-loop/switch region; other site 358681005343 oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727 358681005344 Domain of unknown function (DUF3899); Region: DUF3899; pfam13038 358681005345 Transcriptional regulator [Transcription]; Region: LysR; COG0583 358681005346 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 358681005347 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 358681005348 dimerization interface [polypeptide binding]; other site 358681005349 Predicted epimerase, PhzC/PhzF homolog [General function prediction only]; Region: COG0384 358681005350 Peptidase S8 family domain in Subtilisin proteins; Region: Peptidases_S8_Subtilisin_subset; cd07477 358681005351 active site 358681005352 catalytic residues [active] 358681005353 Bacterial Ig-like domain (group 2); Region: Big_2; cl02708 358681005354 Bacterial Ig-like domain (group 2); Region: Big_2; cl02708 358681005355 RHS Repeat; Region: RHS_repeat; pfam05593 358681005356 Rhs family protein [Cell envelope biogenesis, outer membrane]; Region: RhsA; COG3209 358681005357 RHS repeat-associated core domain; Region: Rhs_assc_core; TIGR03696 358681005358 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 358681005359 Peptidase inhibitor I9; Region: Inhibitor_I9; pfam05922 358681005360 Peptidase S8 family domain in Subtilisin proteins; Region: Peptidases_S8_Subtilisin_subset; cd07477 358681005361 active site 358681005362 catalytic residues [active] 358681005363 Bacterial Ig-like domain (group 2); Region: Big_2; cl02708 358681005364 Bacterial Ig-like domain (group 2); Region: Big_2; pfam02368 358681005365 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 358681005366 Interdomain contacts; other site 358681005367 Bacterial surface proteins containing Ig-like domains [Cell motility and secretion]; Region: COG5492 358681005368 Bacterial Ig-like domain (group 2); Region: Big_2; pfam02368 358681005369 Bacterial Ig-like domain (group 2); Region: Big_2; pfam02368 358681005370 Bacterial Ig-like domain (group 2); Region: Big_2; pfam02368 358681005371 Alpha-tubulin suppressor and related RCC1 domain-containing proteins [Cell division and chromosome partitioning / Cytoskeleton]; Region: ATS1; COG5184 358681005372 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1_2; pfam13540 358681005373 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415 358681005374 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1_2; pfam13540 358681005375 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1_2; pfam13540 358681005376 Bacterial Ig-like domain (group 2); Region: Big_2; cl02708 358681005377 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415 358681005378 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1_2; pfam13540 358681005379 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415 358681005380 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415 358681005381 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1_2; pfam13540 358681005382 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415 358681005383 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415 358681005384 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415 358681005385 RHS Repeat; Region: RHS_repeat; pfam05593 358681005386 Rhs family protein [Cell envelope biogenesis, outer membrane]; Region: RhsA; COG3209 358681005387 RHS repeat-associated core domain; Region: Rhs_assc_core; TIGR03696 358681005388 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 358681005389 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 358681005390 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 358681005391 Walker A/P-loop; other site 358681005392 ATP binding site [chemical binding]; other site 358681005393 Q-loop/lid; other site 358681005394 ABC transporter signature motif; other site 358681005395 Walker B; other site 358681005396 D-loop; other site 358681005397 H-loop/switch region; other site 358681005398 Methylamine utilisation protein MauE; Region: MauE; pfam07291 358681005399 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 358681005400 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 358681005401 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 358681005402 Coenzyme A binding pocket [chemical binding]; other site 358681005403 cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the...; Region: cyclophilin; cd00317 358681005404 active site 358681005405 Superoxide dismutase [Inorganic ion transport and metabolism]; Region: SodA; COG0605 358681005406 Iron/manganese superoxide dismutases, alpha-hairpin domain; Region: Sod_Fe_N; pfam00081 358681005407 Iron/manganese superoxide dismutases, C-terminal domain; Region: Sod_Fe_C; pfam02777 358681005408 glutamate racemase; Provisional; Region: PRK00865 358681005409 Spore germination protein [General function prediction only]; Region: COG5401 358681005410 Sporulation and spore germination; Region: Germane; pfam10646 358681005411 Sporulation and spore germination; Region: Germane; pfam10646 358681005412 H+ Antiporter protein; Region: 2A0121; TIGR00900 358681005413 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 358681005414 putative substrate translocation pore; other site 358681005415 ribonuclease PH; Reviewed; Region: rph; PRK00173 358681005416 Ribonuclease PH; Region: RNase_PH_bact; cd11362 358681005417 hexamer interface [polypeptide binding]; other site 358681005418 active site 358681005419 NTPase/HAM1. This family consists of the HAM1 protein and pyrophosphate-releasing xanthosine/ inosine triphosphatase. HAM1 protects the cell against mutagenesis by the base analog 6-N-hydroxylaminopurine (HAP) in E. Coli and S. cerevisiae. A...; Region: HAM1; cd00515 358681005420 active site 358681005421 dimerization interface [polypeptide binding]; other site 358681005422 Escherichia coli YfcE and related proteins, metallophosphatase domain; Region: MPP_YfcE; cd00841 358681005423 active site 358681005424 metal binding site [ion binding]; metal-binding site 358681005425 homotetramer interface [polypeptide binding]; other site 358681005426 trigger factor; Provisional; Region: tig; PRK01490 358681005427 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 358681005428 Bacterial trigger factor protein (TF) C-terminus; Region: Trigger_C; pfam05698 358681005429 Clp protease; Region: CLP_protease; pfam00574 358681005430 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017 358681005431 oligomer interface [polypeptide binding]; other site 358681005432 active site residues [active] 358681005433 ATP-dependent protease ATP-binding subunit ClpX; Provisional; Region: clpX; PRK05342 358681005434 ClpX C4-type zinc finger; Region: zf-C4_ClpX; pfam06689 358681005435 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 358681005436 Walker A motif; other site 358681005437 ATP binding site [chemical binding]; other site 358681005438 Walker B motif; other site 358681005439 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 358681005440 ATP-dependent protease LonB; Region: spore_lonB; TIGR02902 358681005441 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 358681005442 Walker A motif; other site 358681005443 ATP binding site [chemical binding]; other site 358681005444 Walker B motif; other site 358681005445 arginine finger; other site 358681005446 Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362 358681005447 ATP-dependent Lon protease, bacterial type [Posttranslational modification, protein turnover, chaperones]; Region: Lon; COG0466 358681005448 Found in ATP-dependent protease La (LON); Region: LON; smart00464 358681005449 Found in ATP-dependent protease La (LON); Region: LON; smart00464 358681005450 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 358681005451 Walker A motif; other site 358681005452 ATP binding site [chemical binding]; other site 358681005453 Walker B motif; other site 358681005454 arginine finger; other site 358681005455 Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362 358681005456 YihA (EngB) GTPase family; Region: YihA_EngB; cd01876 358681005457 G1 box; other site 358681005458 GTP/Mg2+ binding site [chemical binding]; other site 358681005459 Switch I region; other site 358681005460 G2 box; other site 358681005461 G3 box; other site 358681005462 Switch II region; other site 358681005463 G4 box; other site 358681005464 G5 box; other site 358681005465 beta-N-acetylglucosaminidase; Region: NAGidase; pfam07555 358681005466 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 358681005467 EamA-like transporter family; Region: EamA; pfam00892 358681005468 EamA-like transporter family; Region: EamA; pfam00892 358681005469 glutamyl-tRNA reductase; Reviewed; Region: hemA; PRK00045 358681005470 NADP-binding domain of glutamyl-tRNA reductase; Region: NAD_bind_Glutamyl_tRNA_reduct; cd05213 358681005471 tRNA; other site 358681005472 putative tRNA binding site [nucleotide binding]; other site 358681005473 putative NADP binding site [chemical binding]; other site 358681005474 Glutamyl-tRNAGlu reductase, dimerisation domain; Region: GlutR_dimer; pfam00745 358681005475 Cytochrome C assembly protein; Region: Cytochrom_C_asm; cl00504 358681005476 porphobilinogen deaminase; Reviewed; Region: hemC; PRK00072 358681005477 Hydroxymethylbilane synthase (HMBS), also known as porphobilinogen deaminase (PBGD), is an intermediate enzyme in the biosynthetic pathway of tetrapyrrolic ring systems, such as heme, chlorophylls, and vitamin B12. HMBS catalyzes the conversion of...; Region: HMBS; cd00494 358681005478 domain interfaces; other site 358681005479 active site 358681005480 uroporphyrinogen-III synthase; Reviewed; Region: hemD; PRK05928 358681005481 Uroporphyrinogen-III synthase (HemD) catalyzes the asymmetrical cyclization of tetrapyrrole (linear) to uroporphyrinogen-III, the fourth step in the biosynthesis of heme. This ubiquitous enzyme is present in eukaryotes, bacteria and archaea. Mutations in...; Region: HemD; cd06578 358681005482 active site 358681005483 Porphobilinogen synthase (PBGS), which is also called delta-aminolevulinic acid dehydratase (ALAD), catalyzes the condensation of two 5-aminolevulinic acid (ALA) molecules to form the pyrrole porphobilinogen (PBG), which is the second step in the...; Region: ALAD_PBGS; cd00384 358681005484 dimer interface [polypeptide binding]; other site 358681005485 active site 358681005486 Schiff base residues; other site 358681005487 glutamate-1-semialdehyde aminotransferase; Provisional; Region: PRK00062 358681005488 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 358681005489 inhibitor-cofactor binding pocket; inhibition site 358681005490 pyridoxal 5'-phosphate binding site [chemical binding]; other site 358681005491 catalytic residue [active] 358681005492 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3708 358681005493 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 358681005494 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 358681005495 methyl indole-3-acetate methyltransferase; Region: PLN02211; cl17657 358681005496 bifunctional UDP-sugar hydrolase/5'-nucleotidase periplasmic precursor; Reviewed; Region: ushA; PRK09558 358681005497 Escherichia coli UshA-like family, N-terminal metallophosphatase domain; Region: MPP_UshA_N_like; cd00845 358681005498 active site 358681005499 metal binding site [ion binding]; metal-binding site 358681005500 5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872 358681005501 Predicted transcriptional regulators [Transcription]; Region: COG1695 358681005502 Transcriptional regulator PadR-like family; Region: PadR; pfam03551 358681005503 Protein of unknown function (DUF1700); Region: DUF1700; pfam08006 358681005504 Domain of unknown function (DUF4097); Region: DUF4097; pfam13349 358681005505 Domain of unknown function (DUF4098); Region: DUF4098; pfam13345 358681005506 Domain of unknown function (DUF4098); Region: DUF4098; pfam13345 358681005507 Uroporphyrinogen decarboxylase (URO-D) is a dimeric cytosolic enzyme that decarboxylates the four acetate side chains of uroporphyrinogen III (uro-III) to create coproporphyrinogen III, without requiring any prosthetic groups or cofactors. This reaction...; Region: URO-D; cd00717 358681005508 substrate binding site [chemical binding]; other site 358681005509 active site 358681005510 ferrochelatase; Provisional; Region: PRK12435 358681005511 Class II Chelatase: a family of ATP-independent monomeric or homodimeric enzymes that catalyze the insertion of metal into protoporphyrin rings. This family includes protoporphyrin IX ferrochelatase (HemH), sirohydrochlorin ferrochelatase (SirB) and the...; Region: Chelatase_Class_II; cl02784 358681005512 active site 358681005513 Ferrochelatase, C-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_C; cd00419 358681005514 active site 358681005515 N-terminal domain interface [polypeptide binding]; other site 358681005516 protoporphyrinogen oxidase; Reviewed; Region: PRK11883 358681005517 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 358681005518 stage VI sporulation protein D; Region: spore_VI_D; TIGR02907 358681005519 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 358681005520 spore coat protein, CotS family; Region: spore_CotS; TIGR02906 358681005521 spore coat protein YsxE; Region: spore_ysxE; TIGR02904 358681005522 spore coat protein, CotS family; Region: spore_CotS; TIGR02906 358681005523 Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228 358681005524 Histidine kinase-like ATPase domain; Region: HATPase_c_2; pfam13581 358681005525 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075 358681005526 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 358681005527 anti sigma factor interaction site; other site 358681005528 regulatory phosphorylation site [posttranslational modification]; other site 358681005529 valyl-tRNA synthetase; Reviewed; Region: valS; PRK05729 358681005530 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 358681005531 active site 358681005532 HIGH motif; other site 358681005533 nucleotide binding site [chemical binding]; other site 358681005534 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 358681005535 catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817 358681005536 active site 358681005537 KMSKS motif; other site 358681005538 Anticodon-binding domain of valyl tRNA synthetases; Region: Anticodon_Ia_Val; cd07962 358681005539 tRNA binding surface [nucleotide binding]; other site 358681005540 anticodon binding site; other site 358681005541 Valyl tRNA synthetase tRNA binding arm; Region: Val_tRNA-synt_C; pfam10458 358681005542 Folylpolyglutamate synthase [Coenzyme metabolism]; Region: FolC; COG0285 358681005543 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 358681005544 UDP-N-acetylmuramate--L-alanine ligase; Provisional; Region: murC; PRK00421 358681005545 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 358681005546 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 358681005547 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 358681005548 3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK12879 358681005549 Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830 358681005550 dimer interface [polypeptide binding]; other site 358681005551 active site 358681005552 CoA binding pocket [chemical binding]; other site 358681005553 Type IV leader peptidase family; Region: Peptidase_A24; pfam01478 358681005554 Domain of unknown function (DUF4321); Region: DUF4321; pfam14209 358681005555 Nucleotide binding protein Maf. Maf has been implicated in inhibition of septum formation in eukaryotes, bacteria and archaea, but homologs in B.subtilis and S.cerevisiae are nonessential for cell division. Maf has been predicted to be a nucleotide- or...; Region: Maf; cd00555 358681005556 active site 358681005557 dimer interface [polypeptide binding]; other site 358681005558 hypothetical protein; Reviewed; Region: PRK00024 358681005559 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cl14786 358681005560 helix-hairpin-helix signature motif; other site 358681005561 Mov34/MPN/PAD-1 family; Region: MPN_DUF2466; cd08071 358681005562 MPN+ (JAMM) motif; other site 358681005563 Zinc-binding site [ion binding]; other site 358681005564 rod shape-determining protein MreB; Provisional; Region: PRK13927 358681005565 MreB and similar proteins; Region: MreB_like; cd10225 358681005566 nucleotide binding site [chemical binding]; other site 358681005567 Mg binding site [ion binding]; other site 358681005568 putative protofilament interaction site [polypeptide binding]; other site 358681005569 RodZ interaction site [polypeptide binding]; other site 358681005570 Cell shape-determining protein [Cell envelope biogenesis, outer membrane]; Region: MreC; COG1792 358681005571 rod shape-determining protein MreC; Region: MreC; pfam04085 358681005572 rod shape-determining protein MreD; Region: shape_MreD; TIGR03426 358681005573 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 358681005574 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 358681005575 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 358681005576 septum formation inhibitor; Reviewed; Region: minC; PRK00513 358681005577 Septum formation inhibitor MinC, C-terminal domain; Region: MinC_C; pfam03775 358681005578 septum site-determining protein MinD; Region: minD_bact; TIGR01968 358681005579 Bacterial cell division requires the formation of a septum at mid-cell. The site is determined by the min operon products MinC, MinD and MinE. MinC is a nonspecific inhibitor of the septum protein FtsZ. MinE is the supressor of MinC. MinD plays a pivotal...; Region: MinD; cd02036 358681005580 Switch I; other site 358681005581 Switch II; other site 358681005582 rod shape-determining protein RodA; Region: rodA_shape; TIGR02210 358681005583 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 358681005584 DNA-binding site [nucleotide binding]; DNA binding site 358681005585 RNA-binding motif; other site 358681005586 Peptidase family M23; Region: Peptidase_M23; pfam01551 358681005587 SpoIVFB Site-2 protease (S2P), a zinc metalloprotease (MEROPS family M50B), regulates intramembrane proteolysis (RIP), and is involved in the pro-sigmaK pathway of bacterial spore formation. SpoIVFB (sporulation protein, stage IV cell wall formation, F...; Region: S2P-M50_SpoIVFB; cd06161 358681005588 Peptidase family M50; Region: Peptidase_M50; pfam02163 358681005589 active site 358681005590 putative substrate binding region [chemical binding]; other site 358681005591 Acetyltransferase (GNAT) domain; Region: Acetyltransf_8; pfam13523 358681005592 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 358681005593 Coenzyme A binding pocket [chemical binding]; other site 358681005594 ribonuclease, Rne/Rng family; Region: RNaseEG; TIGR00757 358681005595 S1_RNase_E: RNase E and RNase G, S1-like RNA-binding domain. RNase E is an essential endoribonuclease in the processing and degradation of RNA. In addition to its role in mRNA degradation, RNase E has also been implicated in the processing of rRNA, and...; Region: S1_RNase_E; cd04453 358681005596 homodimer interface [polypeptide binding]; other site 358681005597 oligonucleotide binding site [chemical binding]; other site 358681005598 50S ribosomal protein L21; Validated; Region: rplU; PRK05573 358681005599 Protein of unknown function (DUF464); Region: DUF464; pfam04327 358681005600 50S ribosomal protein L27; Validated; Region: rpmA; PRK05435 358681005601 GTPase CgtA; Reviewed; Region: obgE; PRK12297 358681005602 GTP1/OBG; Region: GTP1_OBG; pfam01018 358681005603 Obg GTPase; Region: Obg; cd01898 358681005604 G1 box; other site 358681005605 GTP/Mg2+ binding site [chemical binding]; other site 358681005606 Switch I region; other site 358681005607 G2 box; other site 358681005608 G3 box; other site 358681005609 Switch II region; other site 358681005610 G4 box; other site 358681005611 G5 box; other site 358681005612 Domain of unknown function (DUF1967); Region: DUF1967; pfam09269 358681005613 PilZ domain; Region: PilZ; pfam07238 358681005614 Protein of unknown function (DUF1641); Region: DUF1641; pfam07849 358681005615 NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252 358681005616 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 358681005617 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 358681005618 hypothetical protein; Provisional; Region: PRK04435 358681005619 C-terminal ACT domain of a small (; 147 a.a.) putative phenylalanine biosynthetic pathway protein described in Bacillus subtilis (BS) PheB (PheB-BS) and related domains; Region: ACT_PheB-BS; cd04888 358681005620 homoserine dehydrogenase; Provisional; Region: PRK06349 358681005621 Homoserine dehydrogenase, NAD binding domain; Region: NAD_binding_3; pfam03447 358681005622 Homoserine dehydrogenase; Region: Homoserine_dh; pfam00742 358681005623 ACT_HSDH_Hom CD includes the C-terminal ACT domain of the NAD(P)H-dependent, homoserine dehydrogenase (HSDH) and related domains; Region: ACT_HSDH-Hom; cd04881 358681005624 threonine synthase; Reviewed; Region: PRK06721 358681005625 Threonine synthase is a pyridoxal phosphate (PLP) dependent enzyme that catalyses the last reaction in the synthesis of threonine from aspartate. It proceeds by converting O-phospho-L-homoserine (OPH) into threonine and inorganic phosphate. In plants; Region: Thr-synth_1; cd01563 358681005626 homodimer interface [polypeptide binding]; other site 358681005627 pyridoxal 5'-phosphate binding site [chemical binding]; other site 358681005628 catalytic residue [active] 358681005629 homoserine kinase; Provisional; Region: PRK01212 358681005630 prephenate dehydratase; Provisional; Region: PRK11898 358681005631 Prephenate dehydratase; Region: PDT; pfam00800 358681005632 C-terminal ACT domain of the bifunctional chorismate mutase-prephenate dehydratase (CM-PDT) enzyme and the prephenate dehydratase (PDT) enzyme; Region: ACT_CM-PDT; cd04905 358681005633 putative L-Phe binding site [chemical binding]; other site 358681005634 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 358681005635 spore coat protein, CotS family; Region: spore_CotS; TIGR02906 358681005636 spore coat protein YsxE; Region: spore_ysxE; TIGR02904 358681005637 bifunctional 2',3'-cyclic nucleotide 2'-phosphodiesterase/3'-nucleotidase periplasmic precursor protein; Reviewed; Region: cpdB; PRK09420 358681005638 Escherichia coli CpdB and related proteins, N-terminal metallophosphatase domain; Region: MPP_CpdB_N; cd07410 358681005639 active site 358681005640 metal binding site [ion binding]; metal-binding site 358681005641 5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872 358681005642 BofC C-terminal domain; Region: BofC_C; pfam08955 358681005643 Holliday junction resolvases (HJRs) are endonucleases that specifically resolve Holliday junction DNA intermediates during homologous recombination. HJR's occur in archaea, bacteria, and in the mitochondria of certain fungi, however this CD...; Region: RuvC_resolvase; cd00529 358681005644 active site 358681005645 putative DNA-binding cleft [nucleotide binding]; other site 358681005646 dimer interface [polypeptide binding]; other site 358681005647 Holliday junction DNA helicase RuvA; Reviewed; Region: ruvA; PRK00116 358681005648 RuvA N terminal domain; Region: RuvA_N; pfam01330 358681005649 RuvA, C-terminal domain; Region: RuvA_C; pfam07499 358681005650 Holliday junction DNA helicase RuvB; Reviewed; Region: ruvB; PRK00080 358681005651 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 358681005652 Walker A motif; other site 358681005653 ATP binding site [chemical binding]; other site 358681005654 Walker B motif; other site 358681005655 arginine finger; other site 358681005656 Holliday junction DNA helicase ruvB C-terminus; Region: RuvB_C; pfam05491 358681005657 Protein of unknown function (DUF2905); Region: DUF2905; pfam11146 358681005658 Stage II sporulation protein; Region: SpoIID; pfam08486 358681005659 SpoIID/LytB domain; Region: SpoIID_LytB; TIGR02669 358681005660 S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Provisional; Region: queA; PRK00147 358681005661 S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Region: queA; TIGR00113 358681005662 queuine tRNA-ribosyltransferase; Provisional; Region: tgt; PRK00112 358681005663 Queuine/archaeosine tRNA-ribosyltransferase [Translation, ribosomal structure and biogenesis]; Region: Tgt; COG0343 358681005664 Preprotein translocase subunit; Region: YajC; pfam02699 358681005665 putative membrane protein, TIGR04086 family; Region: TIGR04086_membr 358681005666 Mg2+ and Co2+ transporters [Inorganic ion transport and metabolism]; Region: CorA; COG0598 358681005667 Thermotoga maritima CorA-like family; Region: TmCorA-like; cd12822 358681005668 oligomer interface [polypeptide binding]; other site 358681005669 metal binding site [ion binding]; metal-binding site 358681005670 metal binding site [ion binding]; metal-binding site 358681005671 putative Cl binding site [ion binding]; other site 358681005672 aspartate ring; other site 358681005673 basic sphincter; other site 358681005674 hydrophobic gate; other site 358681005675 periplasmic entrance; other site 358681005676 Predicted membrane protein [Function unknown]; Region: COG2323 358681005677 stage V sporulation protein B; Region: spore_V_B; TIGR02900 358681005678 Stage V sporulation protein B, also known as Stage III sporulation protein F, and related proteins; Region: MATE_SpoVB_like; cd13124 358681005679 Post-transcriptional regulator; Region: Post_transc_reg; pfam13797 358681005680 preprotein translocase subunit SecD; Reviewed; Region: secD; PRK05812 358681005681 E2 binding domain; Region: E2_bind; pfam08825 358681005682 protein-export membrane protein, SecD/SecF family; Region: 2A0604s01; TIGR00916 358681005683 preprotein translocase subunit SecF; Reviewed; Region: secF; PRK13022 358681005684 Protein export membrane protein; Region: SecD_SecF; pfam02355 358681005685 single-stranded-DNA-specific exonuclease RecJ; Region: recJ; TIGR00644 358681005686 DHH family; Region: DHH; pfam01368 358681005687 DHHA1 domain; Region: DHHA1; pfam02272 358681005688 Single-strand DNA-specific exonuclease, C terminal domain; Region: ssDNA-exonuc_C; cl11538 358681005689 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 358681005690 active site 358681005691 Guanosine polyphosphate pyrophosphohydrolases/synthetases [Signal transduction mechanisms / Transcription]; Region: SpoT; COG0317 358681005692 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 358681005693 Zn2+ binding site [ion binding]; other site 358681005694 Mg2+ binding site [ion binding]; other site 358681005695 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 358681005696 synthetase active site [active] 358681005697 NTP binding site [chemical binding]; other site 358681005698 metal binding site [ion binding]; metal-binding site 358681005699 TGS_RelA_SpoT: The RelA (SpoT) protein, also referred to as ppGpp hydrolase/synthetase, is a ribosome-associated protein that is activated during amino acid starvation and thought to mediate the stringent response. RelA contains a TGS domain, named after...; Region: TGS_RelA_SpoT; cd01668 358681005700 ACT domain found C-terminal of the RelA/SpoT domains; Region: ACT_RelA-SpoT; cd04876 358681005701 D-Tyrosyl-tRNAtyr deacylases; a class of tRNA-dependent hydrolases which are capable of hydrolyzing the ester bond of D-Tyrosyl-tRNA reducing the level of cellular D-Tyrosine while recycling the peptidyl-tRNA; found in bacteria and in eukaryotes but not...; Region: Dtyr_deacylase; cd00563 358681005702 putative active site [active] 358681005703 dimerization interface [polypeptide binding]; other site 358681005704 putative tRNAtyr binding site [nucleotide binding]; other site 358681005705 short chain dehydrogenase; Provisional; Region: PRK08309 358681005706 DinB family; Region: DinB; cl17821 358681005707 DinB superfamily; Region: DinB_2; pfam12867 358681005708 Bacterial SH3 domain; Region: SH3_3; pfam08239 358681005709 Bacterial SH3 domain; Region: SH3_3; pfam08239 358681005710 Bacterial SH3 domain; Region: SH3_3; pfam08239 358681005711 Bacterial SH3 domain; Region: SH3_3; pfam08239 358681005712 Bacterial SH3 domain; Region: SH3_3; pfam08239 358681005713 N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860 358681005714 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 358681005715 active site 358681005716 metal binding site [ion binding]; metal-binding site 358681005717 coproporphyrinogen III oxidase; Provisional; Region: PRK08207 358681005718 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 358681005719 FeS/SAM binding site; other site 358681005720 histidyl-tRNA synthetase; Reviewed; Region: hisS; PRK00037 358681005721 Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for...; Region: HisRS-like_core; cd00773 358681005722 dimer interface [polypeptide binding]; other site 358681005723 motif 1; other site 358681005724 active site 358681005725 motif 2; other site 358681005726 motif 3; other site 358681005727 HisRS Histidyl-anticodon binding domain. HisRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: HisRS_anticodon; cd00859 358681005728 anticodon binding site; other site 358681005729 aspartyl-tRNA synthetase; Validated; Region: aspS; PRK00476 358681005730 EcAspRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli aspartyl-tRNA synthetase (AspRS), the human mitochondrial (mt) AspRS-2, the discriminating (D) Thermus thermophilus AspRS-1, and the nondiscriminating (ND)...; Region: EcAspRS_like_N; cd04317 358681005731 dimer interface [polypeptide binding]; other site 358681005732 anticodon binding site; other site 358681005733 Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of...; Region: AspRS_core; cd00777 358681005734 homodimer interface [polypeptide binding]; other site 358681005735 motif 1; other site 358681005736 active site 358681005737 motif 2; other site 358681005738 GAD domain; Region: GAD; pfam02938 358681005739 Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of...; Region: AspRS_core; cd00777 358681005740 motif 3; other site 358681005741 Dinucleotide-utilizing enzymes involved in molybdopterin and thiamine biosynthesis family 1 [Coenzyme metabolism]; Region: COG1179 358681005742 Family of activating enzymes (E1) of ubiquitin-like proteins related to the E.coli hypothetical protein ygdL. The common reaction mechanism catalyzed by E1-like enzymes begins with a nucleophilic attack of the C-terminal carboxylate of the ubiquitin-like...; Region: YgdL_like; cd00755 358681005743 putative ATP binding site [chemical binding]; other site 358681005744 putative substrate interface [chemical binding]; other site 358681005745 recombination factor protein RarA; Reviewed; Region: PRK13342 358681005746 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 358681005747 Walker A motif; other site 358681005748 ATP binding site [chemical binding]; other site 358681005749 Walker B motif; other site 358681005750 arginine finger; other site 358681005751 MgsA AAA+ ATPase C terminal; Region: MgsA_C; pfam12002 358681005752 Predicted transcriptional regulator [Transcription]; Region: COG1959 358681005753 Transcriptional regulator; Region: Rrf2; pfam02082 358681005754 cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402 358681005755 Cysteine sulfinate desulfinase/cysteine desulfurase and related enzymes [Amino acid transport and metabolism]; Region: NifS; COG1104 358681005756 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 358681005757 catalytic residue [active] 358681005758 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 358681005759 dimerization interface [polypeptide binding]; other site 358681005760 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 358681005761 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 358681005762 dimer interface [polypeptide binding]; other site 358681005763 putative CheW interface [polypeptide binding]; other site 358681005764 helicase, putative, RecD/TraA family; Region: recD_rel; TIGR01448 358681005765 AAA domain; Region: AAA_30; pfam13604 358681005766 Family description; Region: UvrD_C_2; pfam13538 358681005767 PRC-barrel domain; Region: PRC; pfam05239 358681005768 PRC-barrel domain; Region: PRC; pfam05239 358681005769 integral membrane protein, YjbE family; Region: R_switched_YjbE; TIGR03717 358681005770 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 358681005771 Domain of unknown function DUF20; Region: UPF0118; pfam01594 358681005772 alanyl-tRNA synthetase; Reviewed; Region: alaS; PRK00252 358681005773 Alanyl-tRNA synthetase (AlaRS) class II core catalytic domain. AlaRS is a homodimer. It is responsible for the attachment of alanine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: AlaRS_core; cd00673 358681005774 motif 1; other site 358681005775 active site 358681005776 motif 2; other site 358681005777 motif 3; other site 358681005778 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863 358681005779 DHHA1 domain; Region: DHHA1; pfam02272 358681005780 hypothetical protein; Provisional; Region: PRK05473 358681005781 Holliday junction resolvase-like protein; Reviewed; Region: PRK00109 358681005782 Protein of unknown function (DUF1292); Region: DUF1292; pfam06949 358681005783 YceG-like family; Region: YceG; pfam02618 358681005784 proteins similar to Escherichia coli yceG; Region: yceG_like; cd08010 358681005785 dimerization interface [polypeptide binding]; other site 358681005786 Predicted O-methyltransferase [General function prediction only]; Region: COG4122 358681005787 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 358681005788 S-adenosylmethionine binding site [chemical binding]; other site 358681005789 Uridine kinase [Nucleotide transport and metabolism]; Region: Udk; COG0572 358681005790 Uridine monophosphate kinase (UMPK, EC 2.7.1.48), also known as uridine kinase or uridine-cytidine kinase (UCK), catalyzes the reversible phosphoryl transfer from ATP to uridine or cytidine to yield UMP or CMP. In the primidine nucleotide-salvage pathway; Region: UMPK; cd02023 358681005791 ATP-binding site [chemical binding]; other site 358681005792 Sugar specificity; other site 358681005793 Pyrimidine base specificity; other site 358681005794 Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768 358681005795 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 358681005796 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 358681005797 Mpr1p, Pad1p N-terminal (MPN) domains; Region: MPN; cl13996 358681005798 c-di-GMP phosphodiesterase class II (HD-GYP domain) [Signal transduction mechanisms]; Region: COG2206 358681005799 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 358681005800 Zn2+ binding site [ion binding]; other site 358681005801 Mg2+ binding site [ion binding]; other site 358681005802 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 358681005803 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 358681005804 Coenzyme A binding pocket [chemical binding]; other site 358681005805 Protein of unknown function (DUF1266); Region: DUF1266; pfam06889 358681005806 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 358681005807 HSP70 interaction site [polypeptide binding]; other site 358681005808 TPR repeat; Region: TPR_11; pfam13414 358681005809 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 358681005810 TPR motif; other site 358681005811 binding surface 358681005812 Tetratricopeptide repeat; Region: TPR_16; pfam13432 358681005813 Molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: DnaK; COG0443 358681005814 Nucleotide-binding domain of Escherichia coli HscC and similar proteins; Region: HscC_like_NBD; cd10235 358681005815 nucleotide binding site [chemical binding]; other site 358681005816 putative NEF/HSP70 interaction site [polypeptide binding]; other site 358681005817 SBD interface [polypeptide binding]; other site 358681005818 SMI1 / KNR4 family (SUKH-1); Region: SMI1_KNR4; pfam09346 358681005819 Domain of unknown function (DUF4284); Region: DUF4284; pfam14112 358681005820 Ankyrin repeats (many copies); Region: Ank_4; pfam13637 358681005821 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 358681005822 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 358681005823 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 358681005824 potential frameshift: common BLAST hit: gi|188586355|ref|YP_001917900.1| Resolvase domain 358681005825 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961 358681005826 Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cd00338 358681005827 catalytic residues [active] 358681005828 Recombinase; Region: Recombinase; pfam07508 358681005829 Protein of unknown function (DUF2834); Region: DUF2834; pfam11196 358681005830 Predicted membrane protein [Function unknown]; Region: COG2323 358681005831 Domain of Unknown Function (DUF1259); Region: DUF1529; pfam07485 358681005832 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961 358681005833 Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cd00338 358681005834 catalytic residues [active] 358681005835 catalytic nucleophile [active] 358681005836 Recombinase; Region: Recombinase; pfam07508 358681005837 Recombinase zinc beta ribbon domain; Region: Zn_ribbon_recom; pfam13408 358681005838 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 358681005839 DNA binding residues [nucleotide binding] 358681005840 Uncharacterized protein, 4-oxalocrotonate tautomerase homolog [General function prediction only]; Region: COG1942 358681005841 active site 1 [active] 358681005842 dimer interface [polypeptide binding]; other site 358681005843 hexamer interface [polypeptide binding]; other site 358681005844 active site 2 [active] 358681005845 Bulb-type mannose-specific lectin. The domain contains a three-fold internal repeat (beta-prism architecture). The consensus sequence motif QXDXNXVXY is involved in alpha-D-mannose recognition. Lectins are carbohydrate-binding proteins which specifically...; Region: B_lectin; cd00028 358681005846 Bulb-type mannose-specific lectin; Region: B_lectin; smart00108 358681005847 mannose binding site [chemical binding]; other site 358681005848 dimerization interface [polypeptide binding]; other site 358681005849 ASC-1 homology domain, ASC-1-like subfamily. The ASCH domain, a small beta-barrel domain found in all three kingdoms of life, resembles the RNA-binding PUA domain and may also interact with RNA. ASCH has been proposed to function as an RNA-binding domain...; Region: ASCH_ASC-1_like; cd06554 358681005850 putative transposase OrfB; Reviewed; Region: PHA02517 358681005851 HTH-like domain; Region: HTH_21; pfam13276 358681005852 Integrase core domain; Region: rve; pfam00665 358681005853 Integrase core domain; Region: rve_3; pfam13683 358681005854 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961 358681005855 Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cd00338 358681005856 catalytic residues [active] 358681005857 phage transcriptional regulator, ArpU family; Region: phage_arpU; TIGR01637 358681005858 MarR family; Region: MarR_2; pfam12802 358681005859 Stage 0 sporulation protein J (antagonist of Soj) containing ParB-like nuclease domain [Transcription]; Region: Spo0J; COG1475 358681005860 ParB-like nuclease domain; Region: ParBc; pfam02195 358681005861 DNA modification methylase [DNA replication, recombination, and repair]; Region: COG0863 358681005862 DNA methylase; Region: N6_N4_Mtase; pfam01555 358681005863 Deoxyribonuclease NucA/NucB; Region: DNase_NucA_NucB; pfam14040 358681005864 Domain of unknown function (DUF2935); Region: DUF2935; pfam11155 358681005865 Domain of unknown function (DUF2935); Region: DUF2935; pfam11155 358681005866 Domain of unknown function (DUF2935); Region: DUF2935; pfam11155 358681005867 Domain of unknown function (DUF2935); Region: DUF2935; pfam11155 358681005868 Protein of unknown function (DUF1648); Region: DUF1648; pfam07853 358681005869 Protein of unknown function, DUF606; Region: DUF606; pfam04657 358681005870 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 358681005871 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 358681005872 ligand binding site [chemical binding]; other site 358681005873 Crp-like helix-turn-helix domain; Region: HTH_Crp_2; pfam13545 358681005874 Protein of unknown function, DUF606; Region: DUF606; pfam04657 358681005875 CarD-like/TRCF domain; Region: CarD_CdnL_TRCF; cl00588 358681005876 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 358681005877 Coenzyme A binding pocket [chemical binding]; other site 358681005878 Bacterial capsule synthesis protein PGA_cap; Region: PGA_cap; smart00854 358681005879 CapA and related proteins, metallophosphatase domain; Region: MPP_CapA; cd07381 358681005880 putative active site [active] 358681005881 putative metal binding site [ion binding]; other site 358681005882 UDP-N-acetylmuramyl pentapeptide synthase [Cell envelope biogenesis, outer membrane]; Region: MurF; COG0770 358681005883 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 358681005884 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 358681005885 YtkA-like; Region: YtkA; pfam13115 358681005886 YtkA-like; Region: YtkA; pfam13115 358681005887 Uncharacterized protein SCO1/SenC/PrrC, involved in biogenesis of respiratory and photosynthetic systems [General function prediction only]; Region: COG1999 358681005888 SCO (an acronym for Synthesis of Cytochrome c Oxidase) family; composed of proteins similar to Sco1, a membrane-anchored protein possessing a soluble domain with a TRX fold. Members of this family are required for the proper assembly of cytochrome c...; Region: SCO; cd02968 358681005889 Cu(I) binding site [ion binding]; other site 358681005890 Cytochrome c oxidase caa3 assembly factor (Caa3_CtaG); Region: Caa3_CtaG; cl09173 358681005891 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 358681005892 catalytic residues [active] 358681005893 Disulfide bond formation protein DsbB; Region: DsbB; cl00649 358681005894 phosphoprotein phosphatases of the metallophosphatase superfamily, metallophosphatase domain; Region: MPP_PPP_family; cd00144 358681005895 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 358681005896 active site 358681005897 metal binding site [ion binding]; metal-binding site 358681005898 Cupin; Region: Cupin_1; smart00835 358681005899 NAD-dependent deacetylase; Provisional; Region: PRK00481 358681005900 SIR2 superfamily of proteins includes silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein/histone deacetylation, where the acetyl group from the lysine epsilon-amino group is transferred to the ADP-ribose moiety of NAD+; Region: SIR2; cl00195 358681005901 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 358681005902 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 358681005903 Walker A/P-loop; other site 358681005904 ATP binding site [chemical binding]; other site 358681005905 Q-loop/lid; other site 358681005906 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 358681005907 ABC transporter signature motif; other site 358681005908 Walker B; other site 358681005909 D-loop; other site 358681005910 ABC transporter; Region: ABC_tran_2; pfam12848 358681005911 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 358681005912 ABC transporter; Region: ABC_tran_2; pfam12848 358681005913 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 358681005914 Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376 358681005915 HIT family: HIT (Histidine triad) proteins, named for a motif related to the sequence HxHxH/Qxx (x, a hydrophobic amino acid), are a superfamily of nucleotide hydrolases and transferases, which act on the alpha-phosphate of ribonucleotides. On the basis...; Region: HIT_like; cl00228 358681005916 nucleotide binding site/active site [active] 358681005917 HIT family signature motif; other site 358681005918 catalytic residue [active] 358681005919 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 358681005920 Coenzyme A binding pocket [chemical binding]; other site 358681005921 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 358681005922 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 358681005923 Coenzyme A binding pocket [chemical binding]; other site 358681005924 Scaffold protein Nfu/NifU N terminal; Region: Nfu_N; smart00932 358681005925 Virulence factor; Region: Virulence_fact; pfam13769 358681005926 HEAT repeats; Region: HEAT_2; pfam13646 358681005927 HEAT repeats; Region: HEAT_2; pfam13646 358681005928 E-Z type HEAT repeats; Region: EZ_HEAT; smart00567 358681005929 Phytoene dehydrogenase and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG1233 358681005930 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 358681005931 Beta-lactamase enzyme family; Region: Beta-lactamase2; pfam13354 358681005932 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 358681005933 The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504 358681005934 peptide binding site [polypeptide binding]; other site 358681005935 Predicted glutamine amidotransferases [General function prediction only]; Region: COG2071 358681005936 Subgroup of proteins having the Type 1 glutamine amidotransferase (GATase1) domain; Region: GATase1_2; cd01745 358681005937 catalytic triad [active] 358681005938 Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450 358681005939 Peroxiredoxin (PRX) family, Bacterioferritin comigratory protein (BCP) subfamily; composed of thioredoxin-dependent thiol peroxidases, widely expressed in pathogenic bacteria, that protect cells against toxicity from reactive oxygen species by reducing...; Region: PRX_BCP; cd03017 358681005940 catalytic triad [active] 358681005941 DNA Polymerase IV/Kappa; Region: PolY_Pol_IV_kappa; cd03586 358681005942 active site 358681005943 DNA polymerase IV; Validated; Region: PRK02406 358681005944 DNA binding site [nucleotide binding] 358681005945 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 358681005946 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 358681005947 Coenzyme A binding pocket [chemical binding]; other site 358681005948 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 358681005949 Major Facilitator Superfamily; Region: MFS_1; pfam07690 358681005950 putative substrate translocation pore; other site 358681005951 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 358681005952 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 358681005953 Predicted hydrolase of the HAD superfamily [General function prediction only]; Region: COG2179 358681005954 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 358681005955 active site 358681005956 motif I; other site 358681005957 motif II; other site 358681005958 GTPase YqeH; Provisional; Region: PRK13796 358681005959 Circularly permuted YqeH GTPase; Region: YqeH; cd01855 358681005960 GTP/Mg2+ binding site [chemical binding]; other site 358681005961 G4 box; other site 358681005962 G5 box; other site 358681005963 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cd00882 358681005964 G1 box; other site 358681005965 G1 box; other site 358681005966 GTP/Mg2+ binding site [chemical binding]; other site 358681005967 Switch I region; other site 358681005968 G2 box; other site 358681005969 G2 box; other site 358681005970 Switch I region; other site 358681005971 G3 box; other site 358681005972 G3 box; other site 358681005973 Switch II region; other site 358681005974 Switch II region; other site 358681005975 shikimate 5-dehydrogenase; Reviewed; Region: aroE; PRK00258 358681005976 Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501 358681005977 NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065 358681005978 shikimate binding site; other site 358681005979 NAD(P) binding site [chemical binding]; other site 358681005980 Predicted RNA-binding protein containing KH domain, possibly ribosomal protein [Translation, ribosomal structure and biogenesis]; Region: COG1534 358681005981 nicotinic acid mononucleotide adenylyltransferase; Provisional; Region: nadD; PRK00071 358681005982 Nicotinamide/nicotinate mononucleotide adenylyltransferase; Region: NMNAT; cd02165 358681005983 active site 358681005984 (T/H)XGH motif; other site 358681005985 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 358681005986 Zn2+ binding site [ion binding]; other site 358681005987 Mg2+ binding site [ion binding]; other site 358681005988 iojap-like ribosome-associated protein; Region: iojap_ybeB; TIGR00090 358681005989 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 358681005990 S-adenosylmethionine binding site [chemical binding]; other site 358681005991 leucyl-tRNA synthetase; Validated; Region: leuS; PRK00390 358681005992 catalytic core domain of leucyl-tRNA synthetases; Region: LeuRS_core; cd00812 358681005993 HIGH motif; other site 358681005994 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 358681005995 catalytic core domain of leucyl-tRNA synthetases; Region: LeuRS_core; cd00812 358681005996 active site 358681005997 KMSKS motif; other site 358681005998 Anticodon-binding domain of bacterial and eukaryotic mitochondrial leucyl tRNA synthetases; Region: Anticodon_Ia_Leu_BEm; cd07958 358681005999 tRNA binding surface [nucleotide binding]; other site 358681006000 NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; cl17232 358681006001 late competence protein ComER; Validated; Region: PRK07680 358681006002 SLBB domain; Region: SLBB; pfam10531 358681006003 comEA protein; Region: comE; TIGR01259 358681006004 Helix-hairpin-helix motif; Region: HHH; pfam00633 358681006005 exosortase A system-associated amidotransferase 1; Region: eps_aminotran_1; TIGR03108 358681006006 Glutamine amidotransferases class-II (GATase) asparagine synthase_B type. Asparagine synthetase B catalyses the ATP-dependent conversion of aspartate to asparagine. This enzyme is a homodimer, with each monomer composed of a glutaminase domain and a...; Region: AsnB; cd00712 358681006007 active site 358681006008 dimer interface [polypeptide binding]; other site 358681006009 The C-terminal domain of Asparagine Synthase B. This domain is always found associated n-terminal amidotransferase domain. Family members that contain this domain catalyse the conversion of aspartate to asparagine. Asparagine synthetase B catalyzes the...; Region: Asn_Synthase_B_C; cd01991 358681006010 Ligand Binding Site [chemical binding]; other site 358681006011 Molecular Tunnel; other site 358681006012 Domain of unknown function (DUF4131); Region: DUF4131; pfam13567 358681006013 DNA internalization-related competence protein ComEC/Rec2; Region: ComEC_Rec2; TIGR00361 358681006014 Competence protein; Region: Competence; pfam03772 358681006015 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 358681006016 RNA polymerase sigma factor SigW; Provisional; Region: PRK09641 358681006017 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 358681006018 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 358681006019 DNA binding residues [nucleotide binding] 358681006020 DNA polymerase III subunit delta; Reviewed; Region: holA; PRK05574 358681006021 DNA polymerase III, delta subunit; Region: DNA_pol3_delta; pfam06144 358681006022 30S ribosomal protein S20; Reviewed; Region: rpsT; PRK00239 358681006023 germination protease; Provisional; Region: PRK02858 358681006024 Stage II sporulation protein P (SpoIIP); Region: SpoIIP; pfam07454 358681006025 stage II sporulation protein P; Region: spore_II_P; TIGR02867 358681006026 Protein of unknown function (DUF3679); Region: DUF3679; pfam12438 358681006027 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 358681006028 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 358681006029 Walker A/P-loop; other site 358681006030 ATP binding site [chemical binding]; other site 358681006031 Q-loop/lid; other site 358681006032 ABC transporter signature motif; other site 358681006033 Walker B; other site 358681006034 D-loop; other site 358681006035 H-loop/switch region; other site 358681006036 oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727 358681006037 dipeptide transporter ATP-binding subunit; Provisional; Region: dppF; PRK11308 358681006038 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 358681006039 Walker A/P-loop; other site 358681006040 ATP binding site [chemical binding]; other site 358681006041 Q-loop/lid; other site 358681006042 ABC transporter signature motif; other site 358681006043 Walker B; other site 358681006044 D-loop; other site 358681006045 H-loop/switch region; other site 358681006046 oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727 358681006047 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 358681006048 Type IV pili component [Cell motility and secretion]; Region: COG5461 358681006049 The substrate-binding component of an ABC-type dipeptide import system contains the type 2 periplasmic binding fold; Region: PBP2_DppA_like; cd08493 358681006050 peptide binding site [polypeptide binding]; other site 358681006051 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 358681006052 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 358681006053 dimer interface [polypeptide binding]; other site 358681006054 conserved gate region; other site 358681006055 putative PBP binding loops; other site 358681006056 ABC-ATPase subunit interface; other site 358681006057 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 358681006058 N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911 358681006059 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 358681006060 dimer interface [polypeptide binding]; other site 358681006061 conserved gate region; other site 358681006062 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 358681006063 ABC-ATPase subunit interface; other site 358681006064 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 358681006065 Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006 358681006066 Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321 358681006067 Similar to Prolidase and Aminopeptidase P. The members of this subfamily presumably catalyse hydrolysis of Xaa-Pro dipeptides and/or release of any N-terminal amino acid, including proline, that is linked with proline; Region: APP-like; cd01092 358681006068 active site 358681006069 proposed F420-0 ABC transporter, periplasmic F420-0 binding protein; Region: F420-O_ABCperi; TIGR03868 358681006070 Metal binding protein TroA_a. These proteins are predicted to function as initial receptors in ABC transport of metal ions in eubacteria. They belong to the TroA superfamily of helical backbone metal receptor proteins that share a distinct fold and...; Region: TroA_a; cd01148 358681006071 putative ligand binding residues [chemical binding]; other site 358681006072 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 358681006073 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 358681006074 ABC-ATPase subunit interface; other site 358681006075 dimer interface [polypeptide binding]; other site 358681006076 putative PBP binding regions; other site 358681006077 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 358681006078 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 358681006079 Walker A/P-loop; other site 358681006080 ATP binding site [chemical binding]; other site 358681006081 Q-loop/lid; other site 358681006082 ABC transporter signature motif; other site 358681006083 Walker B; other site 358681006084 D-loop; other site 358681006085 H-loop/switch region; other site 358681006086 Zn-dependent dipeptidase, microsomal dipeptidase homolog [Amino acid transport and metabolism]; Region: COG2355 358681006087 renal dipeptidase (rDP), best studied in mammals and also called membrane or microsomal dipeptidase, is a membrane-bound glycoprotein hydrolyzing dipeptides and is involved in hydrolytic metabolism of penem and carbapenem beta-lactam antibiotics; Region: rDP_like; cd01301 358681006088 active site 358681006089 dimer interface [polypeptide binding]; other site 358681006090 Predicted acyl esterases [General function prediction only]; Region: COG2936 358681006091 X-Pro dipeptidyl-peptidase C-terminal non-catalytic domain; Region: PepX_C; smart00939 358681006092 Rubredoxin_like; nonheme iron binding domain containing a [Fe(SCys)4] center. The family includes rubredoxins, a small electron transfer protein, and a slightly smaller modular rubredoxin domain present in rubrerythrin and nigerythrin and detected either...; Region: rubredoxin_like; cl00202 358681006093 iron binding site [ion binding]; other site 358681006094 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 358681006095 S-adenosylmethionine binding site [chemical binding]; other site 358681006096 RNA polymerase factor sigma C; Reviewed; Region: PRK09415 358681006097 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 358681006098 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 358681006099 DNA binding residues [nucleotide binding] 358681006100 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 358681006101 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 358681006102 Coenzyme A binding pocket [chemical binding]; other site 358681006103 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 358681006104 motif 1; other site 358681006105 HIT family: HIT (Histidine triad) proteins, named for a motif related to the sequence HxHxH/Qxx (x, a hydrophobic amino acid), are a superfamily of nucleotide hydrolases and transferases, which act on the alpha-phosphate of ribonucleotides. On the basis...; Region: HIT_like; cl00228 358681006106 GTP-binding protein LepA; Provisional; Region: PRK05433 358681006107 LepA also known as Elongation Factor 4 (EF4); Region: LepA; cd01890 358681006108 G1 box; other site 358681006109 putative GEF interaction site [polypeptide binding]; other site 358681006110 GTP/Mg2+ binding site [chemical binding]; other site 358681006111 Switch I region; other site 358681006112 G2 box; other site 358681006113 G3 box; other site 358681006114 Switch II region; other site 358681006115 G4 box; other site 358681006116 G5 box; other site 358681006117 lepA_II: This subfamily represents the domain II of LepA, a GTP-binding protein localized in the cytoplasmic membrane. The N-terminal domain of LepA shares regions of homology to translation factors. In terms of interaction with the ribosome, EF-G, EF-Tu...; Region: lepA_II; cd03699 358681006118 lepA_C: This family represents the C-terminal region of LepA, a GTP-binding protein localized in the cytoplasmic membrane. LepA is ubiquitous in Bacteria and Eukaryota (e.g. Saccharomyces cerevisiae GUF1p), but is missing from Archaea. LepA exhibits...; Region: lepA_C; cd03709 358681006119 GTP-binding protein LepA C-terminus; Region: LepA_C; pfam06421 358681006120 Isochorismatase family; Region: Isochorismatase; pfam00857 358681006121 YcaC related amidohydrolases; E.coli YcaC is an homooctameric hydrolase with unknown specificity. Despite its weak sequence similarity, it is structurally related to other amidohydrolases and shares conserved active site residues with them; Region: YcaC_related; cd01012 358681006122 catalytic triad [active] 358681006123 dimer interface [polypeptide binding]; other site 358681006124 conserved cis-peptide bond; other site 358681006125 coproporphyrinogen III oxidase; Provisional; Region: PRK08599 358681006126 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 358681006127 FeS/SAM binding site; other site 358681006128 HemN C-terminal domain; Region: HemN_C; pfam06969 358681006129 heat-inducible transcription repressor; Provisional; Region: hrcA; PRK00082 358681006130 Winged helix-turn-helix transcription repressor, HrcA DNA-binding; Region: HrcA_DNA-bdg; pfam03444 358681006131 GrpE; Region: GrpE; pfam01025 358681006132 GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70)-type ATPases. The GrpE dimer binds to the ATPase domain of Hsp70 catalyzing the dissociation of ADP, which enables rebinding of ATP, one step in the Hsp70 reaction cycle in protein folding; Region: GrpE; cd00446 358681006133 dimer interface [polypeptide binding]; other site 358681006134 hsp70 (ATPase domain) interactions [polypeptide binding]; other site 358681006135 molecular chaperone DnaK; Provisional; Region: dnaK; PRK00290 358681006136 Nucleotide-binding domain of human HSPA9 and similar proteins; Region: HSPA9-Ssq1-like_NBD; cd10234 358681006137 nucleotide binding site [chemical binding]; other site 358681006138 NEF interaction site [polypeptide binding]; other site 358681006139 SBD interface [polypeptide binding]; other site 358681006140 chaperone protein DnaJ; Provisional; Region: PRK14280 358681006141 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 358681006142 HSP70 interaction site [polypeptide binding]; other site 358681006143 Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719 358681006144 Zn binding sites [ion binding]; other site 358681006145 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747 358681006146 dimer interface [polypeptide binding]; other site 358681006147 Ribosomal protein L11 methyltransferase (PrmA); Region: PrmA; pfam06325 358681006148 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 358681006149 S-adenosylmethionine binding site [chemical binding]; other site 358681006150 16S ribosomal RNA methyltransferase RsmE; Provisional; Region: PRK11713 358681006151 RNA methyltransferase, RsmE family; Region: TIGR00046 358681006152 2-methylthioadenine synthetase [Translation, ribosomal structure and biogenesis]; Region: MiaB; COG0621 358681006153 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 358681006154 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 358681006155 FeS/SAM binding site; other site 358681006156 Diadenosine hexaphosphate (Ap6A) hydrolase is a member of the Nudix hydrolase superfamily. Ap6A hydrolase specifically hydrolyzes diadenosine polyphosphates, but not ATP or diadenosine triphosphate, and it generates ATP as the product. Ap6A, the most...; Region: Ap6A_hydrolase; cd03673 358681006157 active site 358681006158 Ap6A binding site [chemical binding]; other site 358681006159 nudix motif; other site 358681006160 metal binding site [ion binding]; metal-binding site 358681006161 2-deoxyribose-5-phosphate aldolase (DERA) of the DeoC family; Region: DeoC; cd00959 358681006162 intersubunit interface [polypeptide binding]; other site 358681006163 active site 358681006164 catalytic residue [active] 358681006165 Putative effector of murein hydrolase LrgA [General function prediction only]; Region: COG1380 358681006166 Putative effector of murein hydrolase [Cell envelope biogenesis, outer membrane]; Region: LrgB; COG1346 358681006167 Na/Pi-cotransporter; Region: NaPi_cotrn_rel; TIGR00704 358681006168 Na+/Pi-cotransporter; Region: Na_Pi_cotrans; pfam02690 358681006169 Na+/Pi-cotransporter; Region: Na_Pi_cotrans; pfam02690 358681006170 Predicted SAM-dependent methyltransferases [General function prediction only]; Region: COG1092 358681006171 Putative RNA-binding Domain in PseudoUridine synthase and Archaeosine transglycosylase; Region: PUA; smart00359 358681006172 Middle domain of the SAM-dependent methyltransferase RlmI and related proteins; Region: RlmI_M_like; cd11572 358681006173 putative RNA binding site [nucleotide binding]; other site 358681006174 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 358681006175 S-adenosylmethionine binding site [chemical binding]; other site 358681006176 Domain of unknown function (DUF4177); Region: DUF4177; pfam13783 358681006177 D-alanyl-alanine synthetase A; Reviewed; Region: ddl; PRK01966 358681006178 D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820 358681006179 D-ala D-ala ligase C-terminus; Region: Dala_Dala_lig_C; pfam07478 358681006180 Siderophore synthetase component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: RhbC; COG4264 358681006181 IucA / IucC family; Region: IucA_IucC; pfam04183 358681006182 Ferric iron reductase FhuF-like transporter; Region: FhuF; pfam06276 358681006183 Siderophore synthetase component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: RhbC; COG4264 358681006184 IucA / IucC family; Region: IucA_IucC; pfam04183 358681006185 Ferric iron reductase FhuF-like transporter; Region: FhuF; pfam06276 358681006186 acyl-CoA synthetase; Validated; Region: PRK08308 358681006187 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 358681006188 acyl-activating enzyme (AAE) consensus motif; other site 358681006189 AMP binding site [chemical binding]; other site 358681006190 active site 358681006191 CoA binding site [chemical binding]; other site 358681006192 acyl carrier protein; Provisional; Region: PRK07639 358681006193 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 358681006194 UDP-N-acetylmuramyl pentapeptide synthase [Cell envelope biogenesis, outer membrane]; Region: MurF; COG0770 358681006195 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 358681006196 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 358681006197 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 358681006198 Protein Kinase C Interacting protein related (PKCI): PKCI and related proteins belong to the ubiquitous HIT family of hydrolases that act on alpha-phosphates of ribonucleotides. The members of this subgroup have a conserved HxHxHxx motif (x is a...; Region: PKCI_related; cd01276 358681006199 nucleotide binding site/active site [active] 358681006200 HIT family signature motif; other site 358681006201 catalytic residue [active] 358681006202 30S ribosomal protein S21; Reviewed; Region: rpsU; PRK00270 358681006203 Yqey-like protein; Region: YqeY; pfam09424 358681006204 Membrane-bound serine protease (ClpP class) [Posttranslational modification, protein turnover, chaperones]; Region: NfeD; COG1030 358681006205 Nodulation formation efficiency D (NfeD) is a membrane-bound ClpP-class protease; Region: Clp_protease_NfeD_like; cd07021 358681006206 active site residues [active] 358681006207 dimer interface [polypeptide binding]; other site 358681006208 NfeD-like C-terminal, partner-binding; Region: NfeD; pfam01957 358681006209 hypothetical protein; Provisional; Region: PRK13665 358681006210 sporulation protein YqfC; Region: spore_yqfC; TIGR02856 358681006211 sporulation protein YqfD; Region: spore_yqfD; TIGR02876 358681006212 Putative stage IV sporulation protein YqfD; Region: YqfD; pfam06898 358681006213 Phosphate starvation-inducible protein PhoH, predicted ATPase [Signal transduction mechanisms]; Region: PhoH; COG1702 358681006214 PhoH-like protein; Region: PhoH; pfam02562 358681006215 metal-binding heat shock protein; Provisional; Region: PRK00016 358681006216 Diacylglycerol kinase [Cell envelope biogenesis, outer membrane]; Region: DgkA; COG0818 358681006217 Cytidine deaminase zinc-binding domain. These enzymes are Zn dependent. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a water molecule to form a hydroxide ion that performs a nucleophilic attack on...; Region: cytidine_deaminase; cd01283 358681006218 active site 358681006219 catalytic motif [active] 358681006220 Zn binding site [ion binding]; other site 358681006221 GTPase Era; Reviewed; Region: era; PRK00089 358681006222 E. coli Ras-like protein (Era) is a multifunctional GTPase; Region: Era; cd04163 358681006223 G1 box; other site 358681006224 GTP/Mg2+ binding site [chemical binding]; other site 358681006225 Switch I region; other site 358681006226 G2 box; other site 358681006227 Switch II region; other site 358681006228 G3 box; other site 358681006229 G4 box; other site 358681006230 G5 box; other site 358681006231 KH domain; Region: KH_2; pfam07650 358681006232 YqzL-like protein; Region: YqzL; pfam14006 358681006233 DNA repair protein RecO; Reviewed; Region: recO; PRK00085 358681006234 Recombination protein O N terminal; Region: RecO_N; pfam11967 358681006235 Recombination protein O C terminal; Region: RecO_C; pfam02565 358681006236 Class II Glycyl-tRNA synthetase (GlyRS) alpha subunit core catalytic domain. GlyRS functions as a homodimer in eukaryotes, archaea and some bacteria and as a heterotetramer in the remainder of prokaryotes and in arabidopsis. It is responsible for the...; Region: GlyRS_alpha_core; cd00733 358681006237 dimer interface [polypeptide binding]; other site 358681006238 motif 1; other site 358681006239 active site 358681006240 motif 2; other site 358681006241 motif 3; other site 358681006242 glycyl-tRNA synthetase subunit beta; Validated; Region: glyS; PRK01233 358681006243 HTH domain; Region: HTH_11; pfam08279 358681006244 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair_4; cd04617 358681006245 FOG: CBS domain [General function prediction only]; Region: COG0517 358681006246 PEP synthetase regulatory protein; Provisional; Region: PRK05339 358681006247 CHC2 zinc finger; Region: zf-CHC2; pfam01807 358681006248 DNA primase; Validated; Region: dnaG; PRK05667 358681006249 DNA primase catalytic core, N-terminal domain; Region: Toprim_N; pfam08275 358681006250 TOPRIM_DnaG_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of proteins similar to Escherichia coli DnaG. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_DnaG_primases; cd03364 358681006251 active site 358681006252 metal binding site [ion binding]; metal-binding site 358681006253 interdomain interaction site; other site 358681006254 DnaB-helicase binding domain of primase; Region: DnaB_bind; pfam10410 358681006255 RNA polymerase sigma factor RpoD; Validated; Region: PRK09210 358681006256 Sigma-70 factor, region 1.1; Region: Sigma70_r1_1; pfam03979 358681006257 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 358681006258 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 358681006259 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 358681006260 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 358681006261 DNA binding residues [nucleotide binding] 358681006262 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 358681006263 Short chain acyl-CoA dehydrogenases and eukaryotic short/branched chain acyl-CoA dehydrogenases; Region: SCAD_SBCAD; cd01158 358681006264 FAD binding site [chemical binding]; other site 358681006265 homotetramer interface [polypeptide binding]; other site 358681006266 substrate binding pocket [chemical binding]; other site 358681006267 catalytic base [active] 358681006268 Peptidase S8 family domain in Subtilisin proteins; Region: Peptidases_S8_Subtilisin_subset; cd07477 358681006269 active site 358681006270 catalytic residues [active] 358681006271 Predicted SAM-dependent methyltransferase [General function prediction only]; Region: COG2384 358681006272 Family of unknown function (DUF633); Region: DUF633; pfam04816 358681006273 Uncharacterized conserved protein [Function unknown]; Region: COG0327 358681006274 NIF3 (NGG1p interacting factor 3); Region: NIF3; pfam01784 358681006275 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3323 358681006276 NIF3 (NGG1p interacting factor 3); Region: NIF3; pfam01784 358681006277 Uncharacterized conserved protein [Function unknown]; Region: COG0327 358681006278 S-layer homology domain; Region: SLH; pfam00395 358681006279 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cl12060 358681006280 DNA interaction; other site 358681006281 Tetratricopeptide repeat; Region: TPR_16; pfam13432 358681006282 C-terminal processing peptidase family S41; Region: Peptidase_S41; cl02526 358681006283 C-terminal peptidase (prc); Region: prc; TIGR00225 358681006284 PDZ domain of C-terminal processing-, tail-specific-, and tricorn proteases, which function in posttranslational protein processing, maturation, and disassembly or degradation, in Bacteria, Archaea, and plant chloroplasts. May be responsible for...; Region: PDZ_CTP_protease; cd00988 358681006285 protein binding site [polypeptide binding]; other site 358681006286 C-terminal processing peptidase; serine protease family S41; Region: Peptidase_S41_CPP; cd07560 358681006287 Catalytic dyad [active] 358681006288 Uncharacterized proteins of the AP superfamily [General function prediction only]; Region: COG1524 358681006289 phosphonoacetate hydrolase; Region: hydr_PhnA; TIGR02335 358681006290 Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490 358681006291 putative catalytic site [active] 358681006292 putative metal binding site [ion binding]; other site 358681006293 putative phosphate binding site [ion binding]; other site 358681006294 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 358681006295 EpsO protein participates in the methanolan synthesis; Region: EpsO_like; cd06438 358681006296 DXD motif; other site 358681006297 Predicted Fe-S oxidoreductase [General function prediction only]; Region: COG1242 358681006298 Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584 358681006299 Glycerophosphodiester phosphodiesterase domain of Thermoanaerobacter tengcongensis and similar proteins; Region: GDPD_TtGDE_like; cd08563 358681006300 active site 358681006301 catalytic site [active] 358681006302 metal binding site [ion binding]; metal-binding site 358681006303 dimer interface [polypeptide binding]; other site 358681006304 putative beta-lysine N-acetyltransferase; Region: GNAT_ablB; TIGR03827 358681006305 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 358681006306 Coenzyme A binding pocket [chemical binding]; other site 358681006307 Purine catabolism regulatory protein-like family; Region: PucR; pfam07905 358681006308 Regulator of polyketide synthase expression [Signal transduction mechanisms / Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2508 358681006309 PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556 358681006310 hypothetical protein; Provisional; Region: PRK06917 358681006311 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 358681006312 inhibitor-cofactor binding pocket; inhibition site 358681006313 pyridoxal 5'-phosphate binding site [chemical binding]; other site 358681006314 catalytic residue [active] 358681006315 Acyl CoA:acetate/3-ketoacid CoA transferase, alpha subunit [Lipid metabolism]; Region: AtoD; COG1788 358681006316 3-oxoacid CoA-transferase, B subunit; Region: pcaJ_scoB_fam; TIGR02428 358681006317 acetylornithine deacetylase; Validated; Region: PRK06915 358681006318 M20 Peptidases with similarity to acetylornithine deacetylases and succinyl-diaminopimelate desuccinylases; Region: M20_ArgE_DapE_like2; cd03895 358681006319 metal binding site [ion binding]; metal-binding site 358681006320 dimer interface [polypeptide binding]; other site 358681006321 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 358681006322 Uncharacterized ALDH (y4uC) with similarity to Tortula ruralis aldehyde dehydrogenase ALDH21A1; Region: ALDH_y4uC; cd07149 358681006323 NAD(P) binding site [chemical binding]; other site 358681006324 catalytic residues [active] 358681006325 acyl-CoA synthetase; Validated; Region: PRK08316 358681006326 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 358681006327 Bacterial Bile acid CoA ligases and similar proteins; Region: BACL_like; cd05929 358681006328 acyl-activating enzyme (AAE) consensus motif; other site 358681006329 putative AMP binding site [chemical binding]; other site 358681006330 putative active site [active] 358681006331 putative CoA binding site [chemical binding]; other site 358681006332 Protein of unknown function (DUF1343); Region: DUF1343; pfam07075 358681006333 Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726 358681006334 Catalytic NodB homology domain of Streptococcus mutans polysaccharide deacetylase PgdA, Bacillus subtilis YheN, and similar proteins; Region: CE4_SmPgdA_like; cd10944 358681006335 NodB motif; other site 358681006336 active site 358681006337 catalytic site [active] 358681006338 Zn binding site [ion binding]; other site 358681006339 Copper amine oxidase N-terminal domain; Region: Cu_amine_oxidN1; pfam07833 358681006340 Sporulation lipoprotein YhcN/YlaJ (Spore_YhcN_YlaJ); Region: Spore_YhcN_YlaJ; pfam09580 358681006341 ATP-dependent transcriptional regulator [Transcription]; Region: MalT; COG2909 358681006342 Bacterial transcriptional activator domain; Region: BTAD; smart01043 358681006343 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 358681006344 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 358681006345 putative efflux pump membrane fusion protein; Provisional; Region: PRK03598 358681006346 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 358681006347 HlyD family secretion protein; Region: HlyD_3; pfam13437 358681006348 ABC-2 family transporter protein; Region: ABC2_membrane_3; pfam12698 358681006349 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 358681006350 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 358681006351 Protein of unknown function (DUF3907); Region: DUF3907; pfam13047 358681006352 Peptidase S8 family domain in Thermitase-like proteins; Region: Peptidases_S8_Thermitase_like; cd07484 358681006353 active site 358681006354 catalytic triad [active] 358681006355 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 358681006356 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 358681006357 active site 358681006358 motif I; other site 358681006359 motif II; other site 358681006360 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 358681006361 glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650 358681006362 The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301 358681006363 Walker A/P-loop; other site 358681006364 ATP binding site [chemical binding]; other site 358681006365 Q-loop/lid; other site 358681006366 ABC transporter signature motif; other site 358681006367 Walker B; other site 358681006368 D-loop; other site 358681006369 H-loop/switch region; other site 358681006370 TOBE domain; Region: TOBE; pfam03459 358681006371 PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556 358681006372 Bacillus subtilis YkuE and related proteins, C-terminal metallophosphatase domain; Region: MPP_YkuE_C; cd07385 358681006373 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 358681006374 putative active site [active] 358681006375 putative metal binding site [ion binding]; other site 358681006376 acetyl-CoA synthetase; Provisional; Region: PRK04319 358681006377 Domain of unknown function (DUF3448); Region: DUF3448; pfam11930 358681006378 Uncharacterized subfamily of Acetyl-CoA synthetase like family (ACS); Region: MACS_like_4; cd05969 358681006379 active site 358681006380 acyl-activating enzyme (AAE) consensus motif; other site 358681006381 putative CoA binding site [chemical binding]; other site 358681006382 AMP binding site [chemical binding]; other site 358681006383 Co/Zn/Cd efflux system component [Inorganic ion transport and metabolism]; Region: CzcD; COG1230 358681006384 Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053 358681006385 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 358681006386 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 358681006387 dimerization interface [polypeptide binding]; other site 358681006388 putative DNA binding site [nucleotide binding]; other site 358681006389 putative Zn2+ binding site [ion binding]; other site 358681006390 Predicted permeases [General function prediction only]; Region: COG0701 358681006391 TIGR03943 family protein; Region: TIGR03943 358681006392 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 358681006393 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 358681006394 Coenzyme A binding pocket [chemical binding]; other site 358681006395 Peptidase M1 family containing bacterial Aminopeptidase N; Region: M1_APN_5; cd09604 358681006396 Zn binding site [ion binding]; other site 358681006397 SET domain; Region: SET; pfam00856 358681006398 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 358681006399 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 358681006400 active site 358681006401 phosphorylation site [posttranslational modification] 358681006402 intermolecular recognition site; other site 358681006403 dimerization interface [polypeptide binding]; other site 358681006404 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 358681006405 DNA binding residues [nucleotide binding] 358681006406 dimerization interface [polypeptide binding]; other site 358681006407 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 358681006408 Histidine kinase; Region: HisKA_3; pfam07730 358681006409 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 358681006410 ATP binding site [chemical binding]; other site 358681006411 Mg2+ binding site [ion binding]; other site 358681006412 G-X-G motif; other site 358681006413 4-amino-5-hydroxymethyl-2-methyl-pyrimidine phosphate kinase (HMPP-kinase) catalyzes two consecutive phosphorylation steps in the thiamine phosphate biosynthesis pathway, leading to the synthesis of vitamin B1. The first step is the phosphorylation of...; Region: HMPP_kinase; cd01169 358681006414 dimer interface [polypeptide binding]; other site 358681006415 substrate binding site [chemical binding]; other site 358681006416 ATP binding site [chemical binding]; other site 358681006417 Domain of unknown function (DUF4179); Region: DUF4179; pfam13786 358681006418 RNA polymerase sigma-70 factor, TIGR02954 family; Region: Sig70_famx3 358681006419 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 358681006420 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 358681006421 DNA binding residues [nucleotide binding] 358681006422 Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cl01629 358681006423 DNA repair photolyase [DNA replication, recombination, and repair]; Region: SplB; COG1533 358681006424 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 358681006425 FeS/SAM binding site; other site 358681006426 Deoxynucleoside kinases [Nucleotide transport and metabolism]; Region: COG1428 358681006427 Deoxyribonucleoside kinase (dNK) catalyzes the phosphorylation of deoxyribonucleosides to yield corresponding monophosphates (dNMPs). This family consists of various deoxynucleoside kinases including deoxyribo- cytidine (EC 2.7.1.74), guanosine (EC 2.7.1; Region: dNK; cd01673 358681006428 Substrate-binding site [chemical binding]; other site 358681006429 Substrate specificity [chemical binding]; other site 358681006430 Deoxynucleoside kinases [Nucleotide transport and metabolism]; Region: COG1428 358681006431 Deoxyribonucleoside kinase (dNK) catalyzes the phosphorylation of deoxyribonucleosides to yield corresponding monophosphates (dNMPs). This family consists of various deoxynucleoside kinases including deoxyribo- cytidine (EC 2.7.1.74), guanosine (EC 2.7.1; Region: dNK; cd01673 358681006432 Substrate-binding site [chemical binding]; other site 358681006433 Substrate specificity [chemical binding]; other site 358681006434 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 358681006435 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 358681006436 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_22; cd08359 358681006437 putative dimer interface [polypeptide binding]; other site 358681006438 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 358681006439 Methyltransferase domain; Region: Methyltransf_31; pfam13847 358681006440 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 358681006441 S-adenosylmethionine binding site [chemical binding]; other site 358681006442 PCD_DCoH: The bifunctional protein pterin-4alpha-carbinolamine dehydratase (PCD), also known as DCoH (dimerization cofactor of hepatocyte nuclear factor-1), is both a transcription activator and a metabolic enzyme. DCoH stimulates gene expression by...; Region: PCD_DCoH; cd00488 358681006443 aromatic arch; other site 358681006444 DCoH dimer interaction site [polypeptide binding]; other site 358681006445 DCoH /HNF-1 dimer interaction site [polypeptide binding]; other site 358681006446 DCoH tetramer interaction site [polypeptide binding]; other site 358681006447 substrate binding site [chemical binding]; other site 358681006448 Brown fat-inducible thioesterase (BFIT). Brain acyl-CoA hydrolase (BACH). These enzymes deacylate long-chain fatty acids by hydrolyzing acyl-CoA thioesters to free fatty acids and CoA-SH. Eukaryotic members of this family are expressed in brain, testis; Region: BFIT_BACH; cd03442 358681006449 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 358681006450 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 358681006451 active site 358681006452 catalytic tetrad [active] 358681006453 hypothetical protein; Provisional; Region: PRK07758 358681006454 Predicted thiol-disulfide oxidoreductase [General function prediction only]; Region: COG3011 358681006455 Phenylalanine ammonia-lyase (PAL) and histidine ammonia-lyase (HAL); Region: PAL-HAL; cd00332 358681006456 active sites [active] 358681006457 tetramer interface [polypeptide binding]; other site 358681006458 putative UV damage endonuclease; Provisional; Region: uvsE; PRK02308 358681006459 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 358681006460 MHYT domain (predicted integral membrane sensor domain) [Signal transduction mechanisms]; Region: COG3300 358681006461 putative substrate translocation pore; other site 358681006462 PAS domain S-box; Region: sensory_box; TIGR00229 358681006463 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 358681006464 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 358681006465 metal binding site [ion binding]; metal-binding site 358681006466 active site 358681006467 I-site; other site 358681006468 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 358681006469 permease, urea carboxylase system; Region: ureacarb_perm; TIGR03428 358681006470 putative transposase OrfB; Reviewed; Region: PHA02517 358681006471 HTH-like domain; Region: HTH_21; pfam13276 358681006472 Integrase core domain; Region: rve; pfam00665 358681006473 Integrase core domain; Region: rve_3; pfam13683 358681006474 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 358681006475 Transposase; Region: HTH_Tnp_1; pfam01527 358681006476 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 358681006477 M20 Peptidase Aminoacylase 1 family; Region: M20_Acy1; cd03886 358681006478 metal binding site [ion binding]; metal-binding site 358681006479 dimer interface [polypeptide binding]; other site 358681006480 Protein of unknown function (DUF3100); Region: DUF3100; pfam11299 358681006481 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 358681006482 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 358681006483 Walker A/P-loop; other site 358681006484 ATP binding site [chemical binding]; other site 358681006485 Q-loop/lid; other site 358681006486 ABC transporter signature motif; other site 358681006487 Walker B; other site 358681006488 D-loop; other site 358681006489 H-loop/switch region; other site 358681006490 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 358681006491 SurA N-terminal domain; Region: SurA_N; pfam09312 358681006492 PPIC-type PPIASE domain; Region: Rotamase_2; cl08278 358681006493 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 358681006494 TPR motif; other site 358681006495 binding surface 358681006496 Beta propeller domain; Region: Beta_propel; pfam09826 358681006497 Fumarate hydratase (Fumerase); Region: Fumerase; pfam05681 358681006498 Fumarase C-terminus; Region: Fumerase_C; pfam05683 358681006499 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 358681006500 Imidazolonepropionase and related amidohydrolases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: HutI; COG1228 358681006501 Metallo-dependent hydrolases, subgroup A is part of the superfamily of metallo-dependent hydrolases, a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the...; Region: Met_dep_hydrolase_A; cd01299 358681006502 active site 358681006503 FOG: LysM repeat [Cell envelope biogenesis, outer membrane]; Region: LytE; COG1388 358681006504 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 358681006505 Biogenesis of lysosome-related organelles complex-1 subunit 2; Region: BLOC1_2; pfam10046 358681006506 Major Facilitator Superfamily; Region: MFS_1; pfam07690 358681006507 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 358681006508 putative substrate translocation pore; other site 358681006509 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 358681006510 Small, acid-soluble spore proteins, alpha/beta type; Region: SASP; pfam00269 358681006511 Predicted Fe-S oxidoreductases [General function prediction only]; Region: COG0535 358681006512 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 358681006513 FeS/SAM binding site; other site 358681006514 YfkB-like domain; Region: YfkB; pfam08756 358681006515 Carbonic anhydrases/acetyltransferases, isoleucine patch superfamily [General function prediction only]; Region: PaaY; COG0663 358681006516 Gamma carbonic anhydrase-like: This family is composed of gamma carbonic anhydrase (CA), Ferripyochelin Binding Protein (FBP), E. coli paaY protein, and similar proteins. CAs are zinc-containing enzymes that catalyze the reversible hydration of carbon...; Region: LbH_gamma_CA_like; cd04645 358681006517 trimer interface [polypeptide binding]; other site 358681006518 putative metal binding site [ion binding]; other site 358681006519 Iron-sulphur cluster biosynthesis; Region: Fe-S_biosyn; cl00400 358681006520 S-layer homology domain; Region: SLH; pfam00395 358681006521 S-layer homology domain; Region: SLH; pfam00395 358681006522 hypothetical protein; Provisional; Region: PRK08244 358681006523 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 358681006524 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 358681006525 MarR family; Region: MarR; pfam01047 358681006526 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 358681006527 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 358681006528 Predicted membrane protein [Function unknown]; Region: COG2311 358681006529 Protein of unknown function (DUF418); Region: DUF418; cl12135 358681006530 Protein of unknown function (DUF418); Region: DUF418; pfam04235 358681006531 Anaerobic dehydrogenases, typically selenocysteine-containing [Energy production and conversion]; Region: BisC; COG0243 358681006532 The MopB_3 CD includes a group of related uncharacterized bacterial and archaeal molybdopterin-binding oxidoreductase-like domains with a putative N-terminal iron-sulfur [4Fe-4S] cluster binding site and molybdopterin cofactor binding site. These members...; Region: MopB_3; cd02766 358681006533 putative [4Fe-4S] binding site [ion binding]; other site 358681006534 putative molybdopterin cofactor binding site [chemical binding]; other site 358681006535 The MopB_CT_3 CD includes a group of related uncharacterized bacterial molybdopterin-binding oxidoreductase-like domains with a putative N-terminal iron-sulfur [4Fe-4S] cluster binding site and molybdopterin cofactor binding site. This CD is of the...; Region: MopB_CT_3; cd02786 358681006536 putative molybdopterin cofactor binding site; other site 358681006537 Nucleoside permease [Nucleotide transport and metabolism]; Region: NupC; COG1972 358681006538 Na+ dependent nucleoside transporter N-terminus; Region: Nucleos_tra2_N; pfam01773 358681006539 Nucleoside recognition; Region: Gate; pfam07670 358681006540 Na+ dependent nucleoside transporter C-terminus; Region: Nucleos_tra2_C; pfam07662 358681006541 Glutamine amidotransferases class-II (GATase) asparagine synthase_B type. Asparagine synthetase B catalyses the ATP-dependent conversion of aspartate to asparagine. This enzyme is a homodimer, with each monomer composed of a glutaminase domain and a...; Region: AsnB; cd00712 358681006542 active site 358681006543 asparagine synthase (glutamine-hydrolyzing); Region: asn_synth_AEB; TIGR01536 358681006544 dimer interface [polypeptide binding]; other site 358681006545 The C-terminal domain of Asparagine Synthase B. This domain is always found associated n-terminal amidotransferase domain. Family members that contain this domain catalyse the conversion of aspartate to asparagine. Asparagine synthetase B catalyzes the...; Region: Asn_Synthase_B_C; cd01991 358681006546 Ligand Binding Site [chemical binding]; other site 358681006547 Molecular Tunnel; other site 358681006548 Putative regulator of cell autolysis [Signal transduction mechanisms]; Region: LytS; COG3275 358681006549 5TMR of 5TMR-LYT; Region: 5TM-5TMR_LYT; pfam07694 358681006550 GAF domain; Region: GAF_3; pfam13492 358681006551 Histidine kinase; Region: His_kinase; pfam06580 358681006552 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 358681006553 ATP binding site [chemical binding]; other site 358681006554 Mg2+ binding site [ion binding]; other site 358681006555 G-X-G motif; other site 358681006556 Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms]; Region: LytT; COG3279 358681006557 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 358681006558 active site 358681006559 phosphorylation site [posttranslational modification] 358681006560 intermolecular recognition site; other site 358681006561 dimerization interface [polypeptide binding]; other site 358681006562 LytTr DNA-binding domain; Region: LytTR; smart00850 358681006563 Protein of unknown function, DUF485; Region: DUF485; pfam04341 358681006564 Predicted symporter [General function prediction only]; Region: DhlC; COG4147 358681006565 Uncharacterized bacterial solute carrier 5 subfamily; putative solute-binding domain; Region: SLC5sbd_u4; cd11480 358681006566 Na binding site [ion binding]; other site 358681006567 Predicted symporter [General function prediction only]; Region: DhlC; COG4147 358681006568 Uncharacterized bacterial solute carrier 5 subfamily; putative solute-binding domain; Region: SLC5sbd_u4; cd11480 358681006569 Na binding site [ion binding]; other site 358681006570 Predicted esterase of the alpha-beta hydrolase superfamily [General function prediction only]; Region: COG4667 358681006571 Hypothetical patatin similar to yjju protein of Escherichia coli; Region: Pat_hypo_Ecoli_yjju_like; cd07208 358681006572 active site 358681006573 nucleophile elbow; other site 358681006574 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 358681006575 Zn2+ binding site [ion binding]; other site 358681006576 Mg2+ binding site [ion binding]; other site 358681006577 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 358681006578 Ligand Binding Site [chemical binding]; other site 358681006579 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 358681006580 Ligand Binding Site [chemical binding]; other site 358681006581 H+ Antiporter protein; Region: 2A0121; TIGR00900 358681006582 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 358681006583 putative substrate translocation pore; other site 358681006584 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 358681006585 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 358681006586 QacR-like protein, C-terminal region; Region: TetR_C_5; pfam08360 358681006587 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cd00019 358681006588 AP endonuclease family 2; Region: AP2Ec; smart00518 358681006589 AP (apurinic/apyrimidinic) site pocket; other site 358681006590 DNA interaction; other site 358681006591 Metal-binding active site; metal-binding site 358681006592 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 358681006593 PAS domain; Region: PAS_9; pfam13426 358681006594 putative active site [active] 358681006595 heme pocket [chemical binding]; other site 358681006596 nitrogen regulation protein NR(I); Region: ntrC; TIGR01818 358681006597 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 358681006598 Walker A motif; other site 358681006599 ATP binding site [chemical binding]; other site 358681006600 Walker B motif; other site 358681006601 arginine finger; other site 358681006602 Acyl CoA:acetate/3-ketoacid CoA transferase, alpha subunit [Lipid metabolism]; Region: AtoD; COG1788 358681006603 Coenzyme A transferase; Region: CoA_trans; cl17247 358681006604 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 358681006605 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 358681006606 substrate binding pocket [chemical binding]; other site 358681006607 membrane-bound complex binding site; other site 358681006608 hinge residues; other site 358681006609 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 358681006610 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 358681006611 dimer interface [polypeptide binding]; other site 358681006612 conserved gate region; other site 358681006613 putative PBP binding loops; other site 358681006614 ABC-ATPase subunit interface; other site 358681006615 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 358681006616 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 358681006617 Walker A/P-loop; other site 358681006618 ATP binding site [chemical binding]; other site 358681006619 Q-loop/lid; other site 358681006620 ABC transporter signature motif; other site 358681006621 Walker B; other site 358681006622 D-loop; other site 358681006623 H-loop/switch region; other site 358681006624 putative acyltransferase; Provisional; Region: PRK05790 358681006625 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 358681006626 dimer interface [polypeptide binding]; other site 358681006627 active site 358681006628 arginyl-tRNA synthetase; Reviewed; Region: PRK12451 358681006629 Arginyl tRNA synthetase N terminal domain; Region: Arg_tRNA_synt_N; pfam03485 358681006630 catalytic core domain of arginyl-tRNA synthetases; Region: ArgRS_core; cd00671 358681006631 active site 358681006632 HIGH motif; other site 358681006633 KMSK motif region; other site 358681006634 Anticodon-binding domain of arginyl tRNA synthetases; Region: Anticodon_Ia_Arg; cd07956 358681006635 tRNA binding surface [nucleotide binding]; other site 358681006636 anticodon binding site; other site 358681006637 WXG100 protein secretion system (Wss), protein YukC; Region: YukC; cl01868 358681006638 RNA polymerase factor sigma C; Reviewed; Region: PRK09415 358681006639 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 358681006640 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 358681006641 DNA binding residues [nucleotide binding] 358681006642 Methionine synthase I (cobalamin-dependent), methyltransferase domain [Amino acid transport and metabolism]; Region: MetH; COG0646 358681006643 5-methyltetrahydrofolate--homocysteine methyltransferase; Region: metH; TIGR02082 358681006644 Pterin binding enzymes. This family includes dihydropteroate synthase (DHPS) and cobalamin-dependent methyltransferases such as methyltetrahydrofolate, corrinoid iron-sulfur protein methyltransferase (MeTr) and methionine synthase (MetH). DHPS, a...; Region: Pterin_binding; cl00219 358681006645 substrate binding pocket [chemical binding]; other site 358681006646 dimer interface [polypeptide binding]; other site 358681006647 inhibitor binding site; inhibition site 358681006648 B12 binding domain of methionine synthase. This domain binds methylcobalamin, which it uses as an intermediate methyl carrier from methyltetrahydrofolate (CH3H4folate) to homocysteine (Hcy); Region: methionine_synthase_B12_BD; cd02069 358681006649 B12 binding site [chemical binding]; other site 358681006650 cobalt ligand [ion binding]; other site 358681006651 Vitamin B12 dependent methionine synthase, activation domain; Region: Met_synt_B12; pfam02965 358681006652 Methionine synthase I (cobalamin-dependent), methyltransferase domain [Amino acid transport and metabolism]; Region: MetH; cl14105 358681006653 bifunctional homocysteine S-methyltransferase/5,10-methylenetetrahydrofolate reductase protein; Reviewed; Region: PRK08645 358681006654 Methylenetetrahydrofolate reductase (MTHFR). 5,10-Methylenetetrahydrofolate is reduced to 5-methyltetrahydrofolate by methylenetetrahydrofolate reductase, a cytoplasmic, NAD(P)-dependent enzyme. 5-methyltetrahydrofolate is utilized by methionine synthase...; Region: MTHFR; cd00537 358681006655 FAD binding site [chemical binding]; other site 358681006656 Phosphotransferase enzyme family; Region: APH; pfam01636 358681006657 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cd05120 358681006658 G:T/U mismatch specific DNA glcosylase (MUG); Region: UDG_F2_MUG; cd10028 358681006659 active site 358681006660 SUMO-1 interface [polypeptide binding]; other site 358681006661 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK07666 358681006662 classical (c) SDRs; Region: SDR_c; cd05233 358681006663 NAD(P) binding site [chemical binding]; other site 358681006664 active site 358681006665 Zn-dependent carboxypeptidase [Amino acid transport and metabolism]; Region: COG2317 358681006666 Peptidase family M32 includes thermostable carboxypeptidases TaqCP and PfuCP; Region: M32_Taq; cd06460 358681006667 active site 358681006668 Zn binding site [ion binding]; other site 358681006669 peptide chain release factor 3; Provisional; Region: prfC; PRK00741 358681006670 Release Factor 3 (RF3) protein involved in the terminal step of translocation in bacteria; Region: RF3; cd04169 358681006671 G1 box; other site 358681006672 putative GEF interaction site [polypeptide binding]; other site 358681006673 GTP/Mg2+ binding site [chemical binding]; other site 358681006674 Switch I region; other site 358681006675 G2 box; other site 358681006676 G3 box; other site 358681006677 Switch II region; other site 358681006678 G4 box; other site 358681006679 G5 box; other site 358681006680 RF3_II: this subfamily represents the domain II of bacterial Release Factor 3 (RF3). Termination of protein synthesis by the ribosome requires two release factor (RF) classes. The class II RF3 is a GTPase that removes class I RFs (RF1 or RF2) from the...; Region: RF3_II; cd03689 358681006681 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 358681006682 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 358681006683 Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006 358681006684 Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321 358681006685 Similar to Prolidase and Aminopeptidase P. The members of this subfamily presumably catalyse hydrolysis of Xaa-Pro dipeptides and/or release of any N-terminal amino acid, including proline, that is linked with proline; Region: APP-like; cd01092 358681006686 active site 358681006687 DNA-binding transcriptional repressor PuuR; Provisional; Region: PRK09943 358681006688 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 358681006689 non-specific DNA binding site [nucleotide binding]; other site 358681006690 salt bridge; other site 358681006691 sequence-specific DNA binding site [nucleotide binding]; other site 358681006692 Cupin domain; Region: Cupin_2; pfam07883 358681006693 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 358681006694 putative substrate translocation pore; other site 358681006695 Major Facilitator Superfamily; Region: MFS_1; pfam07690 358681006696 ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614 358681006697 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 358681006698 intersubunit interface [polypeptide binding]; other site 358681006699 Protein of unknown function (DUF817); Region: DUF817; pfam05675 358681006700 Predicted hydrolase of the alpha/beta superfamily [General function prediction only]; Region: COG2819 358681006701 ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614 358681006702 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 358681006703 intersubunit interface [polypeptide binding]; other site 358681006704 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 358681006705 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 358681006706 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 358681006707 Periplasmic binding protein; Region: Peripla_BP_2; pfam01497 358681006708 intersubunit interface [polypeptide binding]; other site 358681006709 Rhodanese-related sulfurtransferase [Inorganic ion transport and metabolism]; Region: SseA; COG2897 358681006710 Thiosulfate sulfurtransferase (TST), N-terminal, inactive domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the 1st repeat, which does not contain the catalytically active Cys residue. The role of the 1st repeat is uncertain, but it...; Region: TST_Repeat_1; cd01448 358681006711 active site residue [active] 358681006712 Thiosulfate sulfurtransferase (TST), C-terminal, catalytic domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the second repeat. Only the second repeat contains the catalytically active Cys residue; Region: TST_Repeat_2; cd01449 358681006713 active site residue [active] 358681006714 Protein of unknown function (DUF502); Region: DUF502; cl01107 358681006715 Protein of unknown function (DUF2621); Region: DUF2621; pfam11084 358681006716 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 358681006717 TPR motif; other site 358681006718 binding surface 358681006719 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_6; cd07242 358681006720 putative dimer interface [polypeptide binding]; other site 358681006721 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 358681006722 ligand binding site [chemical binding]; other site 358681006723 Zn binding site [ion binding]; other site 358681006724 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 358681006725 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 358681006726 dimer interface [polypeptide binding]; other site 358681006727 conserved gate region; other site 358681006728 putative PBP binding loops; other site 358681006729 ABC-ATPase subunit interface; other site 358681006730 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 358681006731 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 358681006732 Walker A/P-loop; other site 358681006733 ATP binding site [chemical binding]; other site 358681006734 Q-loop/lid; other site 358681006735 ABC transporter signature motif; other site 358681006736 Walker B; other site 358681006737 D-loop; other site 358681006738 H-loop/switch region; other site 358681006739 NMT1-like family; Region: NMT1_2; pfam13379 358681006740 ABC transporter, substrate-binding protein, aliphatic sulfonates family; Region: SsuA_fam; TIGR01728 358681006741 ribonuclease Z; Region: RNase_Z; TIGR02651 358681006742 Predicted membrane protein [Function unknown]; Region: COG2364 358681006743 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 358681006744 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 358681006745 Stage VI sporulation protein F; Region: SpoVIF; pfam14069 358681006746 Peptidase S8 family domain in Subtilisin proteins; Region: Peptidases_S8_Subtilisin_subset; cd07477 358681006747 active site 358681006748 catalytic residues [active] 358681006749 Uncharacterized BCR, YaiI/YqxD family COG1671; Region: DUF188; cl00727 358681006750 PAP2_like_2 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which is specific to bacteria, lacks functional characterization and may act as a membrane-associated lipid phosphatase; Region: PAP2_like_2; cd03392 358681006751 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 358681006752 active site 358681006753 Transcriptional regulator [Transcription]; Region: LysR; COG0583 358681006754 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 358681006755 LysR substrate binding domain; Region: LysR_substrate; pfam03466 358681006756 dimerization interface [polypeptide binding]; other site 358681006757 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 358681006758 multidrug resistance protein MdtH; Provisional; Region: PRK11646 358681006759 putative substrate translocation pore; other site 358681006760 S-methylmethionine transporter; Provisional; Region: PRK11387 358681006761 PAS domain; Region: PAS; smart00091 358681006762 PAS fold; Region: PAS_4; pfam08448 358681006763 psp operon transcriptional activator PspF; Region: phageshock_pspF; TIGR02974 358681006764 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 358681006765 Walker A motif; other site 358681006766 ATP binding site [chemical binding]; other site 358681006767 Walker B motif; other site 358681006768 arginine finger; other site 358681006769 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 358681006770 ornithine--oxo-acid transaminase; Provisional; Region: rocD; PRK04073 358681006771 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 358681006772 inhibitor-cofactor binding pocket; inhibition site 358681006773 pyridoxal 5'-phosphate binding site [chemical binding]; other site 358681006774 catalytic residue [active] 358681006775 Sporulation inhibitor A; Region: Sda; pfam08970 358681006776 Sulfite oxidase (SO) family, molybdopterin binding domain. This molybdopterin cofactor (Moco) binding domain is found in a variety of oxidoreductases, main members of this family are nitrate reductase (NR) and sulfite oxidase (SO). SO catalyzes the...; Region: SO_family_Moco; cl00199 358681006777 Putative p-aminobenzoyl-glutamate transporter [Coenzyme metabolism]; Region: AbgT; COG2978 358681006778 p-Aminobenzoyl-glutamate transporter family; Region: ydaH; TIGR00819 358681006779 putative C-S lyase; Region: C_S_lyase_PatB; TIGR04350 358681006780 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 358681006781 pyridoxal 5'-phosphate binding site [chemical binding]; other site 358681006782 homodimer interface [polypeptide binding]; other site 358681006783 catalytic residue [active] 358681006784 Glutaminase [Amino acid transport and metabolism]; Region: GlsA; COG2066 358681006785 glutaminase A; Region: Gln_ase; TIGR03814 358681006786 hypothetical protein; Provisional; Region: PRK13666 358681006787 solute carrier 6 subfamily, Fusobacterium nucleatum Tyt1-like; solute-binding domain; Region: SLC6sbd_Tyt1-Like; cd10336 358681006788 Na2 binding site [ion binding]; other site 358681006789 putative substrate binding site 1 [chemical binding]; other site 358681006790 Na binding site 1 [ion binding]; other site 358681006791 putative substrate binding site 2 [chemical binding]; other site 358681006792 calcium/proton exchanger (cax); Region: cax; TIGR00378 358681006793 Sodium/calcium exchanger protein; Region: Na_Ca_ex; pfam01699 358681006794 Sodium/calcium exchanger protein; Region: Na_Ca_ex; pfam01699 358681006795 spore cortex-lytic enzyme; Region: spore_SleB; TIGR02869 358681006796 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 358681006797 Cell Wall Hydrolase; Region: Hydrolase_2; pfam07486 358681006798 Thiamine pyrophosphate-requiring enzymes [acetolactate synthase, pyruvate dehydrogenase (cytochrome), glyoxylate carboligase, phosphonopyruvate decarboxylase] [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvB; COG0028 358681006799 Pyrimidine (PYR) binding domain of thiamine pyrophosphate (TPP)-dependent enzymes; Region: TPP_enzyme_PYR; cl11410 358681006800 PYR/PP interface [polypeptide binding]; other site 358681006801 dimer interface [polypeptide binding]; other site 358681006802 TPP binding site [chemical binding]; other site 358681006803 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 358681006804 Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cl01629 358681006805 TPP-binding site [chemical binding]; other site 358681006806 Asp23 family; Region: Asp23; pfam03780 358681006807 cell division protein FtsW; Region: ftsW; TIGR02614 358681006808 YugN-like family; Region: YugN; pfam08868 358681006809 FOG: CBS domain [General function prediction only]; Region: COG0517 358681006810 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair_9; cd04622 358681006811 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 358681006812 Helix-Turn-Helix DNA binding domain of MerR-like transcription regulators; Region: HTH_MerR-like; cd00592 358681006813 DNA binding residues [nucleotide binding] 358681006814 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 358681006815 S-adenosylmethionine binding site [chemical binding]; other site 358681006816 Staphylococcal nuclease homologues; Region: SNc; smart00318 358681006817 Staphylococcal nuclease homologues. SNase homologues are found in bacteria, archaea, and eukaryotes. They contain no disufide bonds; Region: SNc; cd00175 358681006818 Catalytic site; other site 358681006819 Ribosomal protein L4/L1 family; Region: Ribosomal_L4; cl00325 358681006820 CHASE3 domain; Region: CHASE3; pfam05227 358681006821 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 358681006822 dimerization interface [polypeptide binding]; other site 358681006823 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 358681006824 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 358681006825 dimer interface [polypeptide binding]; other site 358681006826 putative CheW interface [polypeptide binding]; other site 358681006827 FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202 358681006828 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 358681006829 putative active site [active] 358681006830 heme pocket [chemical binding]; other site 358681006831 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 358681006832 putative active site [active] 358681006833 heme pocket [chemical binding]; other site 358681006834 PAS domain; Region: PAS_9; pfam13426 358681006835 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 358681006836 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 358681006837 metal binding site [ion binding]; metal-binding site 358681006838 active site 358681006839 I-site; other site 358681006840 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 358681006841 MHYT domain (predicted integral membrane sensor domain) [Signal transduction mechanisms]; Region: COG3300 358681006842 Bacterial signalling protein N terminal repeat; Region: MHYT; pfam03707 358681006843 Bacterial signalling protein N terminal repeat; Region: MHYT; pfam03707 358681006844 Bacterial signalling protein N terminal repeat; Region: MHYT; pfam03707 358681006845 PAS domain S-box; Region: sensory_box; TIGR00229 358681006846 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 358681006847 putative active site [active] 358681006848 heme pocket [chemical binding]; other site 358681006849 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 358681006850 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 358681006851 metal binding site [ion binding]; metal-binding site 358681006852 active site 358681006853 I-site; other site 358681006854 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 358681006855 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 358681006856 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 358681006857 metal-binding site [ion binding] 358681006858 Dissimilatory sulfite reductase (desulfoviridin), alpha and beta subunits [Energy production and conversion]; Region: DsrA; COG2221 358681006859 Staphylococcus aureus copper-sensitive operon repressor (CsoR), and related domains; this family was previously known as part of DUF156; Region: SaCsoR-like_DUF156; cd10152 358681006860 putative homodimer interface [polypeptide binding]; other site 358681006861 putative homotetramer interface [polypeptide binding]; other site 358681006862 allosteric switch controlling residues; other site 358681006863 putative metal binding site [ion binding]; other site 358681006864 putative homodimer-homodimer interface [polypeptide binding]; other site 358681006865 Uncharacterized copper-binding protein [Inorganic ion transport and metabolism]; Region: COG4454 358681006866 Spore coat associated protein JA (CotJA); Region: CotJA; pfam11007 358681006867 CotJB protein; Region: CotJB; pfam12652 358681006868 Manganese catalase, ferritin-like diiron-binding domain; Region: Mn_catalase; cd01051 358681006869 dimanganese center [ion binding]; other site 358681006870 Copper amine oxidase N-terminal domain; Region: Cu_amine_oxidN1; pfam07833 358681006871 Copper amine oxidase N-terminal domain; Region: Cu_amine_oxidN1; pfam07833 358681006872 mRNA degradation ribonucleases J1/J2 (metallo-beta-lactamase superfamily) [Translation, ribosomal structure and biogenesis; Replication, recombination and repair]; Region: COG0595 358681006873 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 358681006874 RNA-metabolising metallo-beta-lactamase; Region: RMMBL; pfam07521 358681006875 Domain of unknown function (DUF4399); Region: DUF4399; pfam14347 358681006876 PrcB C-terminal; Region: PrcB_C; pfam14343 358681006877 Helicase conserved C-terminal domain; Region: Helicase_C_3; pfam13625 358681006878 Regulatory protein involved in competence development and sporulation [Replication, recombination and repair; Signal transduction mechanisms]; Region: COG3679 358681006879 Uncharacterized protein conserved in bacteria (DUF2129); Region: DUF2129; cl11453 358681006880 LamB/YcsF family of lactam utilization protein; Region: LamB_YcsF_like; cd10787 358681006881 putative active site [active] 358681006882 ATP-binding cassette domain of the carbohydrate and solute transporters-like; Region: ABC_Carb_Solutes_like; cd03259 358681006883 sulfate ABC transporter, ATP-binding protein; Region: 3a0106s01; TIGR00968 358681006884 Walker A/P-loop; other site 358681006885 ATP binding site [chemical binding]; other site 358681006886 Q-loop/lid; other site 358681006887 ABC transporter signature motif; other site 358681006888 Walker B; other site 358681006889 D-loop; other site 358681006890 H-loop/switch region; other site 358681006891 ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555 358681006892 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 358681006893 dimer interface [polypeptide binding]; other site 358681006894 conserved gate region; other site 358681006895 putative PBP binding loops; other site 358681006896 ABC-ATPase subunit interface; other site 358681006897 ABC-type molybdate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: ModA; COG0725 358681006898 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 358681006899 DNA binding domain, excisionase family; Region: excise; TIGR01764 358681006900 PBP superfamily domain; Region: PBP_like; pfam12727 358681006901 Peptidase Gluzincin family (thermolysin-like proteinases, TLPs) includes peptidases M1, M2, M3, M4, M13, M32 and M36 (fungalysins); Region: GluZincin; cl14813 358681006902 Zn binding site [ion binding]; other site 358681006903 Copper amine oxidase N-terminal domain; Region: Cu_amine_oxidN1; pfam07833 358681006904 shikimate kinase; Reviewed; Region: aroK; PRK00131 358681006905 Shikimate kinase (SK) is the fifth enzyme in the shikimate pathway, a seven-step biosynthetic pathway which converts erythrose-4-phosphate to chorismic acid, found in bacteria, fungi and plants. Chorismic acid is a important intermediate in the synthesis...; Region: SK; cd00464 358681006906 ADP binding site [chemical binding]; other site 358681006907 magnesium binding site [ion binding]; other site 358681006908 putative shikimate binding site; other site 358681006909 YqzE-like protein; Region: YqzE; pfam14038 358681006910 Uncharacterized protein family (UPF0180); Region: UPF0180; pfam03698 358681006911 Bacterial protein YqhG of unknown function; Region: YqhG; pfam11079 358681006912 Bacterial protein YqhG of unknown function; Region: YqhG; pfam11079 358681006913 SNF2 family N-terminal domain; Region: SNF2_N; pfam00176 358681006914 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 358681006915 ATP binding site [chemical binding]; other site 358681006916 putative Mg++ binding site [ion binding]; other site 358681006917 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 358681006918 nucleotide binding region [chemical binding]; other site 358681006919 ATP-binding site [chemical binding]; other site 358681006920 glycine cleavage system aminomethyltransferase T; Reviewed; Region: gcvT; PRK00389 358681006921 Sarcosine oxidase, gamma subunit family; Region: SoxG; cl01893 358681006922 Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669 358681006923 Glycine cleavage system protein P (pyridoxal-binding), N-terminal domain [Amino acid transport and metabolism]; Region: GcvP; COG0403 358681006924 Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613 358681006925 tetramer interface [polypeptide binding]; other site 358681006926 pyridoxal 5'-phosphate binding site [chemical binding]; other site 358681006927 catalytic residue [active] 358681006928 Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613 358681006929 tetramer interface [polypeptide binding]; other site 358681006930 pyridoxal 5'-phosphate binding site [chemical binding]; other site 358681006931 catalytic residue [active] 358681006932 undecaprenyldiphospho-muramoylpentapeptide beta-N-acetylglucosaminyltransferase; Reviewed; Region: PRK12446 358681006933 MurG is an N-acetylglucosaminyltransferase, the last enzyme involved in the intracellular phase of peptidoglycan biosynthesis. It transfers N-acetyl-D-glucosamine (GlcNAc) from UDP-GlcNAc to the C4 hydroxyl of a lipid-linked N-acetylmuramoyl pentapeptide...; Region: GT1_MurG; cd03785 358681006934 active site 358681006935 homodimer interface [polypeptide binding]; other site 358681006936 Lipoate-protein ligase A [Coenzyme metabolism]; Region: LplA; COG0095 358681006937 Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115 358681006938 D-Alanine aminotransferase (D-AAT_like): D-amino acid aminotransferase catalyzes transamination between D-amino acids and their respective alpha-keto acids. It plays a major role in the synthesis of bacterial cell wall components like D-alanine and...; Region: D-AAT_like; cd01558 358681006939 homodimer interface [polypeptide binding]; other site 358681006940 substrate-cofactor binding pocket; other site 358681006941 pyridoxal 5'-phosphate binding site [chemical binding]; other site 358681006942 catalytic residue [active] 358681006943 PA_C5a_like: Protease-associated domain containing proteins like Streptococcus pyogenes C5a peptidase. This group contains various PA domain-containing proteins similar to S. pyogenes C5a, including, i) Vpr, a minor extracellular serine protease from...; Region: PA_C5a_like; cd02133 358681006944 Predicted aminopeptidases [General function prediction only]; Region: Iap; COG2234 358681006945 putative integrin binding motif; other site 358681006946 PA/protease domain interface [polypeptide binding]; other site 358681006947 M28 Zn-peptidases include aminopeptidases and carboxypeptidases; Region: M28; cd02690 358681006948 metal binding site [ion binding]; metal-binding site 358681006949 Uncharacterized membrane protein [Function unknown]; Region: COG3949 358681006950 Predicted flavoprotein [General function prediction only]; Region: COG0431 358681006951 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 358681006952 manganese transport transcriptional regulator; Provisional; Region: PRK03902 358681006953 Iron dependent repressor, N-terminal DNA binding domain; Region: Fe_dep_repress; pfam01325 358681006954 Iron dependent repressor, metal binding and dimerisation domain; Region: Fe_dep_repr_C; pfam02742 358681006955 ExoU and VipD-like proteins; homologus to patatin, cPLA2, and iPLA2; Region: Pat_ExoU_VipD_like; cd07207 358681006956 Predicted esterase of the alpha-beta hydrolase superfamily [General function prediction only]; Region: RssA; COG1752 358681006957 active site 358681006958 nucleophile elbow; other site 358681006959 Predicted metal-dependent enzyme [General function prediction only]; Region: COG3872 358681006960 Conserved membrane protein YqhR; Region: YqhR; pfam11085 358681006961 Dehydroquinase (DHQase), type II. Dehydroquinase (or 3-dehydroquinate dehydratase) catalyzes the reversible dehydration of 3-dehydroquinate to form 3-dehydroshikimate. This reaction is part of two metabolic pathways: the biosynthetic shikimate pathway...; Region: DHQase_II; cd00466 358681006962 Dehydroquinase class II; Region: DHquinase_II; pfam01220 358681006963 active site 358681006964 trimer interface [polypeptide binding]; other site 358681006965 dimer interface [polypeptide binding]; other site 358681006966 Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006 358681006967 Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321 358681006968 Similar to Prolidase and Aminopeptidase P. The members of this subfamily presumably catalyse hydrolysis of Xaa-Pro dipeptides and/or release of any N-terminal amino acid, including proline, that is linked with proline; Region: APP-like; cd01092 358681006969 active site 358681006970 elongation factor P; Validated; Region: PRK00529 358681006971 Elongation factor P (EF-P) KOW-like domain; Region: EFP_N; pfam08207 358681006972 S1_EF-P_repeat_1: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_1; cd04470 358681006973 RNA binding site [nucleotide binding]; other site 358681006974 S1_EF-P_repeat_2: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_2; cd05794 358681006975 RNA binding site [nucleotide binding]; other site 358681006976 Streptomycin adenylyltransferase; Region: Adenyl_transf; pfam04439 358681006977 RNA polymerase sigma factor SigW; Provisional; Region: PRK09641 358681006978 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 358681006979 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 358681006980 DNA binding residues [nucleotide binding] 358681006981 Putative zinc-finger; Region: zf-HC2; pfam13490 358681006982 Domain of unknown function (DUF4179); Region: DUF4179; pfam13786 358681006983 Protein of unknown function (DUF441); Region: DUF441; pfam04284 358681006984 2-phosphosulpholactate phosphatase; Region: 2-ph_phosp; pfam04029 358681006985 Phosphosulfolactate phosphohydrolase and related enzymes [Coenzyme metabolism / General function prediction only]; Region: COG2045 358681006986 (2R)-phospho-3-sulfolactate synthase (ComA); Region: ComA; pfam02679 358681006987 Protein of unknown function (DUF2619); Region: DUF2619; pfam10942 358681006988 stage III sporulation protein AA; Region: spore_III_AA; TIGR02858 358681006989 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 358681006990 Walker A motif; other site 358681006991 ATP binding site [chemical binding]; other site 358681006992 Stage III sporulation protein AB (spore_III_AB); Region: Spore_III_AB; pfam09548 358681006993 stage III sporulation protein AC; Region: spore_III_AC; TIGR02848 358681006994 stage III sporulation protein AD; Region: spore_III_AD; TIGR02849 358681006995 Stage III sporulation protein AE (spore_III_AE); Region: Spore_III_AE; pfam09546 358681006996 Stage III sporulation protein AF (Spore_III_AF); Region: Spore_III_AF; pfam09581 358681006997 stage III sporulation protein AG; Region: spore_III_AG; TIGR02830 358681006998 SpoIIIAH-like protein; Region: SpoIIIAH; pfam12685 358681006999 acetyl-CoA carboxylase biotin carboxyl carrier protein subunit; Validated; Region: PRK06302 358681007000 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 358681007001 carboxyltransferase (CT) interaction site; other site 358681007002 biotinylation site [posttranslational modification]; other site 358681007003 acetyl-CoA carboxylase biotin carboxylase subunit; Validated; Region: PRK08591 358681007004 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 358681007005 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786 358681007006 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 358681007007 Asp23 family; Region: Asp23; pfam03780 358681007008 Asp23 family; Region: Asp23; cl00574 358681007009 Small integral membrane protein (DUF2273); Region: DUF2273; pfam10031 358681007010 Transcription termination factor NusB (N protein-Utilization Substance B). NusB plays a key role in the regulation of ribosomal RNA biosynthesis in eubacteria by modulating the efficiency of transcriptional antitermination. NusB along with other Nus...; Region: Terminator_NusB; cd00619 358681007011 putative RNA binding site [nucleotide binding]; other site 358681007012 metallohydrolase, glycoprotease/Kae1 family; Region: gcp_kae1; TIGR00329 358681007013 Inactive homolog of metal-dependent proteases, putative molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: COG1214; cl17884 358681007014 bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate cyclohydrolase; Provisional; Region: PRK14190 358681007015 Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain; Region: THF_DHG_CYH; pfam00763 358681007016 NADP binding domain of methylene-tetrahydrofolate dehydrogenase/cyclohydrolase; Region: NAD_bind_m-THF_DH_Cyclohyd; cd01080 358681007017 homodimer interface [polypeptide binding]; other site 358681007018 NADP binding site [chemical binding]; other site 358681007019 substrate binding site [chemical binding]; other site 358681007020 exodeoxyribonuclease VII large subunit; Reviewed; Region: xseA; PRK00286 358681007021 ExoVII_LU_OBF: A subfamily of OB folds corresponding to the N-terminal OB-fold domain of Escherichia coli exodeoxyribonuclease VII (ExoVII) large subunit. E. coli ExoVII is composed of two non-identical subunits. E. coli ExoVII is a...; Region: ExoVII_LU_OBF; cd04489 358681007022 generic binding surface II; other site 358681007023 generic binding surface I; other site 358681007024 exodeoxyribonuclease VII small subunit; Provisional; Region: PRK00977 358681007025 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 358681007026 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 358681007027 substrate binding pocket [chemical binding]; other site 358681007028 chain length determination region; other site 358681007029 substrate-Mg2+ binding site; other site 358681007030 catalytic residues [active] 358681007031 aspartate-rich region 1; other site 358681007032 active site lid residues [active] 358681007033 aspartate-rich region 2; other site 358681007034 Peptidase family M3B Oligopeptidase F (PepF); Region: M3B_PepF_1; cd09606 358681007035 oligoendopeptidase, M3 family; Region: M3_not_pepF; TIGR02289 358681007036 active site 358681007037 Zn binding site [ion binding]; other site 358681007038 1-deoxy-D-xylulose-5-phosphate synthase; Provisional; Region: PRK05444 358681007039 Thiamine pyrophosphate (TPP) family, DXS subfamily, TPP-binding module; 1-Deoxy-D-xylulose-5-phosphate synthase (DXS) is a regulatory enzyme of the mevalonate-independent pathway involved in terpenoid biosynthesis. Terpeniods are plant natural products...; Region: TPP_DXS; cd02007 358681007040 TPP-binding site; other site 358681007041 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 358681007042 PYR/PP interface [polypeptide binding]; other site 358681007043 dimer interface [polypeptide binding]; other site 358681007044 TPP binding site [chemical binding]; other site 358681007045 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 358681007046 Predicted rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: COG1189 358681007047 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 358681007048 RNA binding surface [nucleotide binding]; other site 358681007049 FtsJ-like methyltransferase; Region: FtsJ; pfam01728 358681007050 NAD kinase [Coenzyme metabolism]; Region: nadF; COG0061 358681007051 ATP-NAD kinase; Region: NAD_kinase; pfam01513 358681007052 Arginine repressor, DNA binding domain; Region: Arg_repressor; pfam01316 358681007053 arginine repressor; Provisional; Region: PRK04280 358681007054 Arginine repressor, C-terminal domain; Region: Arg_repressor_C; pfam02863 358681007055 ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: RecN; COG0497 358681007056 ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241 358681007057 Walker A/P-loop; other site 358681007058 ATP binding site [chemical binding]; other site 358681007059 Q-loop/lid; other site 358681007060 ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241 358681007061 ABC transporter signature motif; other site 358681007062 Walker B; other site 358681007063 D-loop; other site 358681007064 H-loop/switch region; other site 358681007065 stage IV sporulation protein B; Region: spore_IV_B; TIGR02860 358681007066 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 358681007067 SpoIVB peptidase S55; Region: Peptidase_S55; pfam05580 358681007068 sporulation transcription factor Spo0A; Region: spore_0_A; TIGR02875 358681007069 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 358681007070 active site 358681007071 phosphorylation site [posttranslational modification] 358681007072 intermolecular recognition site; other site 358681007073 dimerization interface [polypeptide binding]; other site 358681007074 Sporulation initiation factor Spo0A C terminal; Region: Spo0A_C; pfam08769 358681007075 Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA_cladeD; cd03379 358681007076 active site clefts [active] 358681007077 zinc binding site [ion binding]; other site 358681007078 dimer interface [polypeptide binding]; other site 358681007079 phosphodiesterase YaeI; Provisional; Region: PRK11340 358681007080 Bacillus subtilis YkuE and related proteins, C-terminal metallophosphatase domain; Region: MPP_YkuE_C; cd07385 358681007081 putative active site [active] 358681007082 putative metal binding site [ion binding]; other site 358681007083 Transcriptional regulator [Transcription]; Region: LysR; COG0583 358681007084 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 358681007085 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 358681007086 dimerization interface [polypeptide binding]; other site 358681007087 Methyltransferase domain; Region: Methyltransf_31; pfam13847 358681007088 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 358681007089 S-adenosylmethionine binding site [chemical binding]; other site 358681007090 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 358681007091 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_9; cd07245 358681007092 dimer interface [polypeptide binding]; other site 358681007093 putative metal binding site [ion binding]; other site 358681007094 Methyltransferase domain; Region: Methyltransf_31; pfam13847 358681007095 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 358681007096 S-adenosylmethionine binding site [chemical binding]; other site 358681007097 Uncharacterized membrane-anchored protein conserved in bacteria [Function unknown]; Region: COG4825 358681007098 Thiamine pyrophosphokinase; Region: TPK; cl08415 358681007099 active site 358681007100 Thiamine pyrophosphokinase C terminal; Region: TPPK_C; pfam12555 358681007101 Protein of unknown function (DUF3186); Region: DUF3186; pfam11382 358681007102 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 358681007103 DPM_DPG-synthase_like is a member of the Glycosyltransferase 2 superfamily; Region: DPM_DPG-synthase_like; cd04179 358681007104 Ligand binding site; other site 358681007105 Putative Catalytic site; other site 358681007106 DXD motif; other site 358681007107 Protein of unknown function (DUF2627); Region: DUF2627; pfam11118 358681007108 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 358681007109 Transcriptional regulator containing PAS, AAA-type ATPase, and DNA-binding domains [Transcription / Signal transduction mechanisms]; Region: RocR; COG3829 358681007110 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 358681007111 putative active site [active] 358681007112 heme pocket [chemical binding]; other site 358681007113 PAS domain; Region: PAS; smart00091 358681007114 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 358681007115 Walker A motif; other site 358681007116 ATP binding site [chemical binding]; other site 358681007117 Walker B motif; other site 358681007118 arginine finger; other site 358681007119 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 358681007120 Glutamate dehydrogenase/leucine dehydrogenase [Amino acid transport and metabolism]; Region: GdhA; COG0334 358681007121 Glu/Leu/Phe/Val dehydrogenase, dimerisation domain; Region: ELFV_dehydrog_N; pfam02812 358681007122 NAD(P) binding domain of leucine dehydrogenase, phenylalanine dehydrogenase, and valine dehydrogenase; Region: NAD_bind_Leu_Phe_Val_DH; cd01075 358681007123 NAD binding site [chemical binding]; other site 358681007124 Phe binding site; other site 358681007125 dihydrolipoamide dehydrogenase; Validated; Region: PRK05976 358681007126 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 358681007127 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 358681007128 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, alpha subunit [Energy production and conversion]; Region: AcoA; COG1071 358681007129 Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000 358681007130 tetramer interface [polypeptide binding]; other site 358681007131 TPP-binding site [chemical binding]; other site 358681007132 heterodimer interface [polypeptide binding]; other site 358681007133 phosphorylation loop region [posttranslational modification] 358681007134 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit [Energy production and conversion]; Region: AcoB; COG0022 358681007135 Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036 358681007136 alpha subunit interface [polypeptide binding]; other site 358681007137 TPP binding site [chemical binding]; other site 358681007138 heterodimer interface [polypeptide binding]; other site 358681007139 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 358681007140 branched-chain alpha-keto acid dehydrogenase subunit E2; Reviewed; Region: PRK11856 358681007141 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 358681007142 E3 interaction surface; other site 358681007143 lipoyl attachment site [posttranslational modification]; other site 358681007144 e3 binding domain; Region: E3_binding; pfam02817 358681007145 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 358681007146 Copper amine oxidase N-terminal domain; Region: Cu_amine_oxidN1; pfam07833 358681007147 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 358681007148 Methylmalonyl-CoA epimerase (MMCE); Region: MMCE; cd07249 358681007149 dimer interface [polypeptide binding]; other site 358681007150 substrate binding site [chemical binding]; other site 358681007151 metal binding site [ion binding]; metal-binding site 358681007152 M20 Peptidase T like enzymes specifically cleave tripeptides; Region: M20_peptT_like; cd05683 358681007153 peptidase T-like protein; Region: PepT-like; TIGR01883 358681007154 metal binding site [ion binding]; metal-binding site 358681007155 putative dimer interface [polypeptide binding]; other site 358681007156 Protein of unknown function (DUF3866); Region: DUF3866; pfam12982 358681007157 ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424 358681007158 dimer interface [polypeptide binding]; other site 358681007159 ADP-ribose binding site [chemical binding]; other site 358681007160 active site 358681007161 nudix motif; other site 358681007162 metal binding site [ion binding]; metal-binding site 358681007163 PHP family phosphoesterase with a Zn ribbon [General function prediction only]; Region: COG1379 358681007164 Polymerase and Histidinol Phosphatase domain; Region: PHP; cl17102 358681007165 PHP-associated; Region: PHP_C; pfam13263 358681007166 Integral membrane protein DUF95; Region: DUF95; cl00572 358681007167 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 358681007168 metal binding site 2 [ion binding]; metal-binding site 358681007169 putative DNA binding helix; other site 358681007170 metal binding site 1 [ion binding]; metal-binding site 358681007171 dimer interface [polypeptide binding]; other site 358681007172 structural Zn2+ binding site [ion binding]; other site 358681007173 Protein of unknown function (DUF4227); Region: DUF4227; pfam14004 358681007174 XerD and XerC integrases, DNA breaking-rejoining enzymes, N- and C-terminal domains. XerD-like integrases are involved in the site-specific integration and excision of lysogenic bacteriophage genomes, transposition of conjugative transposons, termination...; Region: INT_XerDC; cd00798 358681007175 tyrosine recombinase XerD; Region: recomb_XerD; TIGR02225 358681007176 active site 358681007177 Int/Topo IB signature motif; other site 358681007178 phosphopentomutase; Provisional; Region: PRK05362 358681007179 Metalloenzyme superfamily; Region: Metalloenzyme; pfam01676 358681007180 purine nucleoside phosphorylase; Provisional; Region: PRK08202 358681007181 pyrimidine-nucleoside phosphorylase; Reviewed; Region: PRK06078 358681007182 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 358681007183 Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591 358681007184 Pyrimidine nucleoside phosphorylase C-terminal domain; Region: PYNP_C; smart00941 358681007185 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 358681007186 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 358681007187 putative DNA binding site [nucleotide binding]; other site 358681007188 putative Zn2+ binding site [ion binding]; other site 358681007189 AsnC family; Region: AsnC_trans_reg; pfam01037 358681007190 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 358681007191 The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504 358681007192 peptide binding site [polypeptide binding]; other site 358681007193 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 358681007194 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 358681007195 dimer interface [polypeptide binding]; other site 358681007196 conserved gate region; other site 358681007197 putative PBP binding loops; other site 358681007198 ABC-ATPase subunit interface; other site 358681007199 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 358681007200 N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911 358681007201 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 358681007202 dimer interface [polypeptide binding]; other site 358681007203 conserved gate region; other site 358681007204 putative PBP binding loops; other site 358681007205 ABC-ATPase subunit interface; other site 358681007206 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 358681007207 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 358681007208 Walker A/P-loop; other site 358681007209 ATP binding site [chemical binding]; other site 358681007210 Q-loop/lid; other site 358681007211 ABC transporter signature motif; other site 358681007212 Walker B; other site 358681007213 D-loop; other site 358681007214 H-loop/switch region; other site 358681007215 oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727 358681007216 oligopeptide ABC transporter ATP-binding protein OppF; Provisional; Region: PRK15079 358681007217 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 358681007218 Walker A/P-loop; other site 358681007219 ATP binding site [chemical binding]; other site 358681007220 Q-loop/lid; other site 358681007221 ABC transporter signature motif; other site 358681007222 Walker B; other site 358681007223 D-loop; other site 358681007224 H-loop/switch region; other site 358681007225 oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727 358681007226 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 358681007227 dimerization interface [polypeptide binding]; other site 358681007228 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 358681007229 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 358681007230 dimer interface [polypeptide binding]; other site 358681007231 putative CheW interface [polypeptide binding]; other site 358681007232 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872 358681007233 D-alanyl-D-alanine carboxypeptidase [Cell envelope biogenesis, outer membrane]; Region: DacC; COG1686 358681007234 Penicillin-binding protein 5, C-terminal domain; Region: PBP5_C; smart00936 358681007235 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 358681007236 anti sigma factor interaction site; other site 358681007237 regulatory phosphorylation site [posttranslational modification]; other site 358681007238 Anti-sigma regulatory factor (Ser/Thr protein kinase) [Signal transduction mechanisms]; Region: RsbW; COG2172 358681007239 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 358681007240 ATP binding site [chemical binding]; other site 358681007241 Mg2+ binding site [ion binding]; other site 358681007242 G-X-G motif; other site 358681007243 sporulation sigma factor SigF; Validated; Region: PRK05572 358681007244 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 358681007245 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 358681007246 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 358681007247 DNA binding residues [nucleotide binding] 358681007248 Stage V sporulation protein AA; Region: SporV_AA; pfam12164 358681007249 Stage V sporulation protein AB; Region: SpoVAB; pfam13782 358681007250 SpoVA protein; Region: SpoVA; cl04298 358681007251 stage V sporulation protein AD; Validated; Region: PRK08304 358681007252 stage V sporulation protein AD; Provisional; Region: PRK12404 358681007253 SpoVA protein; Region: SpoVA; cl04298 358681007254 Stage V sporulation protein AE1; Region: SpoVAE; pfam14097 358681007255 Bacillus/Clostridium GerA spore germination protein; Region: GerA; pfam03323 358681007256 diaminopimelate decarboxylase; Region: lysA; TIGR01048 358681007257 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Diaminopimelate Decarboxylase; Region: PLPDE_III_DapDC; cd06828 358681007258 active site 358681007259 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 358681007260 substrate binding site [chemical binding]; other site 358681007261 catalytic residues [active] 358681007262 dimer interface [polypeptide binding]; other site 358681007263 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 358681007264 FOG: CBS domain [General function prediction only]; Region: COG0517 358681007265 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354 358681007266 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 358681007267 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 358681007268 metal binding site [ion binding]; metal-binding site 358681007269 active site 358681007270 I-site; other site 358681007271 cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the...; Region: cyclophilin; cd00317 358681007272 active site 358681007273 Uncharacterized homologs of Site-2 protease (S2P), zinc metalloproteases (MEROPS family M50) which cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of the...; Region: S2P-M50_like_1; cd06158 358681007274 Peptidase family M50; Region: Peptidase_M50; pfam02163 358681007275 active site 358681007276 putative substrate binding region [chemical binding]; other site 358681007277 segregation and condensation protein A; Reviewed; Region: scpA; PRK00104 358681007278 segregation and condensation protein B; Reviewed; Region: scpB; PRK00135 358681007279 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872 358681007280 D-alanyl-D-alanine carboxypeptidase [Cell envelope biogenesis, outer membrane]; Region: DacC; COG1686 358681007281 Uncharacterized membrane protein, required for spore maturation in B.subtilis. [General function prediction only]; Region: SpmA; COG2715 358681007282 Uncharacterized membrane protein [Function unknown]; Region: SpmB; COG0700 358681007283 16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187 358681007284 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 358681007285 RNA binding surface [nucleotide binding]; other site 358681007286 Pseudouridine synthases, RsuA subfamily; Region: PseudoU_synth_RsuA_like; cd02870 358681007287 active site 358681007288 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966 358681007289 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 358681007290 catalytic residues [active] 358681007291 ResB protein required for cytochrome c biosynthesis [Posttranslational modification, protein turnover, chaperones]; Region: ResB; cl09125 358681007292 ResB-like family; Region: ResB; pfam05140 358681007293 Cytochrome C assembly protein; Region: Cytochrom_C_asm; cl00504 358681007294 Cytochrome C assembly protein; Region: Cytochrom_C_asm; cl00504 358681007295 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 358681007296 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 358681007297 active site 358681007298 phosphorylation site [posttranslational modification] 358681007299 intermolecular recognition site; other site 358681007300 dimerization interface [polypeptide binding]; other site 358681007301 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 358681007302 DNA binding site [nucleotide binding] 358681007303 Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840 358681007304 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 358681007305 dimerization interface [polypeptide binding]; other site 358681007306 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 358681007307 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 358681007308 putative active site [active] 358681007309 heme pocket [chemical binding]; other site 358681007310 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 358681007311 dimer interface [polypeptide binding]; other site 358681007312 phosphorylation site [posttranslational modification] 358681007313 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 358681007314 ATP binding site [chemical binding]; other site 358681007315 Mg2+ binding site [ion binding]; other site 358681007316 G-X-G motif; other site 358681007317 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 358681007318 Predicted phosphatases [General function prediction only]; Region: Gph; COG0546 358681007319 motif II; other site 358681007320 Na+/H+ antiporter NhaD and related arsenite permeases [Inorganic ion transport and metabolism]; Region: ArsB; COG1055 358681007321 Permease P (pink-eyed dilution). Mutations in the human melanosomal P gene were responsible for classic phenotype of oculocutaneous albinism type 2 (OCA2). Although the precise function of the P protein is unknown, it was predicted to regulate the...; Region: P_permease; cd01116 358681007322 transmembrane helices; other site 358681007323 D-3-phosphoglycerate dehydrogenase; Provisional; Region: PRK13581 358681007324 Phosphoglycerate dehydrogenases, NAD-binding and catalytic domains; Region: PGDH_4; cd12173 358681007325 ligand binding site [chemical binding]; other site 358681007326 NAD binding site [chemical binding]; other site 358681007327 dimerization interface [polypeptide binding]; other site 358681007328 catalytic site [active] 358681007329 C-terminal ACT (regulatory) domain of D-3-phosphoglycerate dehydrogenase (3PGDH); Region: ACT_3PGDH-xct; cd04902 358681007330 putative L-serine binding site [chemical binding]; other site 358681007331 Aminotransferase class I and II; Region: Aminotran_1_2; pfam00155 358681007332 Alanine-glyoxylate aminotransferase (AGAT) family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to alanine-glyoxylate aminotransferase (AGAT); Region: AGAT_like; cd06451 358681007333 homodimer interface [polypeptide binding]; other site 358681007334 pyridoxal 5'-phosphate binding site [chemical binding]; other site 358681007335 catalytic residue [active] 358681007336 Ferredoxin [Energy production and conversion]; Region: Fer; COG1141 358681007337 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4955 358681007338 Superfamily II DNA helicase [DNA replication, recombination, and repair]; Region: RecQ; COG0514 358681007339 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 358681007340 ATP binding site [chemical binding]; other site 358681007341 putative Mg++ binding site [ion binding]; other site 358681007342 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 358681007343 nucleotide binding region [chemical binding]; other site 358681007344 ATP-binding site [chemical binding]; other site 358681007345 CAAX protease self-immunity; Region: Abi; pfam02517 358681007346 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 358681007347 Thioredoxin reductase [Posttranslational modification, protein turnover, chaperones]; Region: TrxB; COG0492 358681007348 Anaerobic glycerol-3-phosphate dehydrogenase [Amino acid transport and metabolism]; Region: GlpB; cl17730 358681007349 adaptor protein; Provisional; Region: PRK02899 358681007350 Uncharacterized proteins, LmbE homologs [Function unknown]; Region: COG2120 358681007351 Glutamate dehydrogenase/leucine dehydrogenase [Amino acid transport and metabolism]; Region: GdhA; COG0334 358681007352 Glu/Leu/Phe/Val dehydrogenase, dimerisation domain; Region: ELFV_dehydrog_N; pfam02812 358681007353 NAD(P) binding domain of glutamate dehydrogenase, subgroup 1; Region: NAD_bind_1_Glu_DH; cd01076 358681007354 NAD(P) binding site [chemical binding]; other site 358681007355 Type II (periplasmic) bacterial L-asparaginase; Region: L-asparaginase_II; cd08964 358681007356 active site 358681007357 homotetramer interface [polypeptide binding]; other site 358681007358 homodimer interface [polypeptide binding]; other site 358681007359 Protease prsW family; Region: PrsW-protease; pfam13367 358681007360 Cell Wall Hydrolase; Region: Hydrolase_2; pfam07486 358681007361 germination protein YpeB; Region: spore_YpeB; TIGR02889 358681007362 c-di-GMP-binding protein [Signal transduction mechanisms]; Region: COG5581 358681007363 Flagellar protein YcgR; Region: YcgR_2; pfam12945 358681007364 PilZ domain; Region: PilZ; pfam07238 358681007365 cytidylate kinase; Provisional; Region: cmk; PRK00023 358681007366 Cytidine monophosphate kinase (CMPK) catalyzes the reversible phosphorylation of cytidine monophosphate (CMP) to produce cytidine diphosphate (CDP), using ATP as the preferred phosphoryl donor; Region: CMPK; cd02020 358681007367 CMP-binding site; other site 358681007368 The sites determining sugar specificity; other site 358681007369 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 358681007370 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 358681007371 putative acyl-acceptor binding pocket; other site 358681007372 30S ribosomal protein S1; Reviewed; Region: rpsA; PRK06676 358681007373 S1_RPS1_repeat_ec1_hs1: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec1_hs1; cd05687 358681007374 RNA binding site [nucleotide binding]; other site 358681007375 S1_RPS1_repeat_ec2_hs2: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec2_hs2; cd04465 358681007376 RNA binding site [nucleotide binding]; other site 358681007377 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 358681007378 RNA binding site [nucleotide binding]; other site 358681007379 S1_RPS1_repeat_hs4: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_hs4; cd05692 358681007380 RNA binding site [nucleotide binding]; other site 358681007381 isopentenyl pyrophosphate isomerase; Provisional; Region: PRK05437 358681007382 Isopentenyl-diphosphate:dimethylallyl diphosphate isomerase type 2 (IDI-2) FMN-binding domain. Two types of IDIs have been characterized at present. The long known IDI-1 is only dependent on divalent metals for activity, whereas IDI-2 requires a metal; Region: IDI-2_FMN; cd02811 358681007383 homotetramer interface [polypeptide binding]; other site 358681007384 FMN binding site [chemical binding]; other site 358681007385 homodimer contacts [polypeptide binding]; other site 358681007386 putative active site [active] 358681007387 putative substrate binding site [chemical binding]; other site 358681007388 YIEGIA protein; Region: YIEGIA; pfam14045 358681007389 GTP-binding protein Der; Reviewed; Region: PRK00093 358681007390 EngA1 GTPase contains the first domain of EngA; Region: EngA1; cd01894 358681007391 G1 box; other site 358681007392 GTP/Mg2+ binding site [chemical binding]; other site 358681007393 Switch I region; other site 358681007394 G2 box; other site 358681007395 Switch II region; other site 358681007396 G3 box; other site 358681007397 G4 box; other site 358681007398 G5 box; other site 358681007399 EngA2 GTPase contains the second domain of EngA; Region: EngA2; cd01895 358681007400 G1 box; other site 358681007401 GTP/Mg2+ binding site [chemical binding]; other site 358681007402 Switch I region; other site 358681007403 G2 box; other site 358681007404 G3 box; other site 358681007405 Switch II region; other site 358681007406 G4 box; other site 358681007407 G5 box; other site 358681007408 membrane protein; Provisional; Region: PRK14405 358681007409 NAD(P)H-dependent glycerol-3-phosphate dehydrogenase; Validated; Region: gpsA; PRK00094 358681007410 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210 358681007411 NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus; Region: NAD_Gly3P_dh_C; pfam07479 358681007412 Stage VI sporulation protein F; Region: SpoVIF; pfam14069 358681007413 Ferredoxin [Energy production and conversion]; Region: Fdx; COG0633 358681007414 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 358681007415 catalytic loop [active] 358681007416 iron binding site [ion binding]; other site 358681007417 Ferredoxin [Energy production and conversion]; Region: Fdx; COG0633 358681007418 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 358681007419 catalytic loop [active] 358681007420 iron binding site [ion binding]; other site 358681007421 stage IV sporulation protein A; Region: spore_IV_A; TIGR02836 358681007422 Stage IV sporulation protein A (spore_IV_A); Region: Spore_IV_A; pfam09547 358681007423 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 358681007424 IHF dimer interface [polypeptide binding]; other site 358681007425 IHF - DNA interface [nucleotide binding]; other site 358681007426 GTP cyclohydrolase I (GTP-CH-I) catalyzes the conversion of GTP into dihydroneopterin triphosphate. The enzyme product is the precursor of tetrahydrofolate in eubacteria, fungi, and plants and of the folate analogs in methanogenic bacteria. In...; Region: GTP_cyclohydro1; cd00642 358681007427 homodecamer interface [polypeptide binding]; other site 358681007428 GTP cyclohydrolase I; Provisional; Region: PLN03044 358681007429 active site 358681007430 putative catalytic site residues [active] 358681007431 zinc binding site [ion binding]; other site 358681007432 GTP-CH-I/GFRP interaction surface; other site 358681007433 Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741 358681007434 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 358681007435 N-acetyl-D-glucosamine binding site [chemical binding]; other site 358681007436 catalytic residue [active] 358681007437 transcription attenuation protein MtrB; Provisional; Region: PRK13251 358681007438 Heptaprenyl diphosphate synthase (HEPPP synthase) subunit 1; Region: HEPPP_synt_1; pfam07307 358681007439 ubiE/COQ5 methyltransferase family; Region: Ubie_methyltran; pfam01209 358681007440 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 358681007441 S-adenosylmethionine binding site [chemical binding]; other site 358681007442 4-hydroxybenzoate polyprenyltransferase and related prenyltransferases [Coenzyme metabolism]; Region: UbiA; cl00337 358681007443 UbiA prenyltransferase family; Region: UbiA; pfam01040 358681007444 aromatic acid decarboxylase; Validated; Region: PRK05920 358681007445 Flavoprotein; Region: Flavoprotein; pfam02441 358681007446 Menaquinone biosynthesis; Region: VitK2_biosynth; pfam02621 358681007447 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 358681007448 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 358681007449 substrate binding pocket [chemical binding]; other site 358681007450 chain length determination region; other site 358681007451 substrate-Mg2+ binding site; other site 358681007452 catalytic residues [active] 358681007453 aspartate-rich region 1; other site 358681007454 active site lid residues [active] 358681007455 aspartate-rich region 2; other site 358681007456 Nucleoside diphosphate kinase Group I (NDPk_I)-like: NDP kinase domains are present in a large family of structurally and functionally conserved proteins from bacteria to humans that generally catalyze the transfer of gamma-phosphates of a nucleoside...; Region: NDPk_I; cd04413 358681007457 active site 358681007458 multimer interface [polypeptide binding]; other site 358681007459 CheR methyltransferase, all-alpha domain; Region: CheR_N; pfam03705 358681007460 Methylase of chemotaxis methyl-accepting proteins [Cell motility and secretion / Signal transduction mechanisms]; Region: CheR; COG1352 358681007461 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 358681007462 S-adenosylmethionine binding site [chemical binding]; other site 358681007463 Chorismate synthase [Amino acid transport and metabolism]; Region: AroC; COG0082 358681007464 Chorismase synthase, the enzyme catalyzing the final step of the shikimate pathway; Region: Chorismate_synthase; cd07304 358681007465 Tetramer interface [polypeptide binding]; other site 358681007466 active site 358681007467 FMN-binding site [chemical binding]; other site 358681007468 Dehydroquinate synthase (DHQS) catalyzes the conversion of DAHP to DHQ in shikimate pathway for aromatic compounds synthesis; Region: DHQS; cd08195 358681007469 active site 358681007470 dimer interface [polypeptide binding]; other site 358681007471 metal binding site [ion binding]; metal-binding site 358681007472 Chorismate mutase (AroH) is one of at least five chorismate-utilizing enzymes present in microorganisms that catalyze the rearrangement of chorismate to prephenic acid, the first committed step in the biosynthesis of aromatic amino acids. In prokaryotes; Region: AroH; cd02185 358681007473 homotrimer interaction site [polypeptide binding]; other site 358681007474 active site 358681007475 anthranilate synthase component I, non-proteobacterial lineages; Region: trpE_most; TIGR00564 358681007476 Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715 358681007477 chorismate binding enzyme; Region: Chorismate_bind; pfam00425 358681007478 anthranilate phosphoribosyltransferase; Provisional; Region: trpD; PRK00188 358681007479 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 358681007480 Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591 358681007481 Indole-3-glycerol phosphate synthase (IGPS); an enzyme in the tryptophan biosynthetic pathway, catalyzing the ring closure reaction of 1-(o-carboxyphenylamino)-1-deoxyribulose-5-phosphate (CdRP) to indole-3-glycerol phosphate (IGP), accompanied by the...; Region: IGPS; cd00331 358681007482 active site 358681007483 ribulose/triose binding site [chemical binding]; other site 358681007484 phosphate binding site [ion binding]; other site 358681007485 substrate (anthranilate) binding pocket [chemical binding]; other site 358681007486 product (indole) binding pocket [chemical binding]; other site 358681007487 Phosphoribosylanthranilate isomerase (PRAI) catalyzes the fourth step of the tryptophan biosynthesis, the conversion of N-(5'- phosphoribosyl)-anthranilate (PRA) to 1-(o-carboxyphenylamino)- 1-deoxyribulose 5-phosphate (CdRP). Most PRAIs are...; Region: PRAI; cd00405 358681007488 active site 358681007489 tryptophan synthase, beta subunit; Region: trpB; TIGR00263 358681007490 Tryptophan synthase-beta: Trptophan synthase is a bifunctional enzyme that catalyses the last two steps in the biosynthesis of L-tryptophan via its alpha and beta reactions. In the alpha reaction, indole 3-glycerol phosphate is cleaved reversibly to...; Region: Trp-synth_B; cd06446 358681007491 pyridoxal 5'-phosphate binding site [chemical binding]; other site 358681007492 catalytic residue [active] 358681007493 tryptophan synthase alpha subunit; Provisional; Region: trpA; CHL00200 358681007494 Ttryptophan synthase (TRPS) alpha subunit (TSA). TPRS is a bifunctional tetrameric enzyme (2 alpha and 2 beta subunits) that catalyzes the last two steps of L-tryptophan biosynthesis. Alpha and beta subunit catalyze two distinct reactions which are both...; Region: Tryptophan_synthase_alpha; cd04724 358681007495 substrate binding site [chemical binding]; other site 358681007496 active site 358681007497 catalytic residues [active] 358681007498 heterodimer interface [polypeptide binding]; other site 358681007499 histidinol-phosphate aminotransferase; Provisional; Region: PRK03158 358681007500 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 358681007501 pyridoxal 5'-phosphate binding site [chemical binding]; other site 358681007502 homodimer interface [polypeptide binding]; other site 358681007503 catalytic residue [active] 358681007504 prephenate dehydrogenase; Validated; Region: PRK06545 358681007505 prephenate dehydrogenase; Validated; Region: PRK08507 358681007506 C-terminal ACT domain of the monofunctional, NAD dependent, prephenate dehydrogenase (PDH); Region: ACT_PDH-BS; cd04909 358681007507 3-phosphoshikimate 1-carboxyvinyltransferase; Provisional; Region: PRK02427 358681007508 EPSP synthase domain. 3-phosphoshikimate 1-carboxyvinyltransferase (5-enolpyruvylshikimate-3-phosphate synthase) (EC 2.5.1.19) catalyses the reaction between shikimate-3-phosphate (S3P) and phosphoenolpyruvate (PEP) to form...; Region: EPSP_synthase; cd01556 358681007509 hinge; other site 358681007510 active site 358681007511 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 358681007512 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 358681007513 RNA polymerase sigma factor RpoE; Provisional; Region: PRK09652 358681007514 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 358681007515 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 358681007516 DNA binding residues [nucleotide binding] 358681007517 Putative zinc-finger; Region: zf-HC2; pfam13490 358681007518 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 358681007519 TPR motif; other site 358681007520 Tetratricopeptide repeat; Region: TPR_12; pfam13424 358681007521 binding surface 358681007522 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 358681007523 binding surface 358681007524 TPR motif; other site 358681007525 A short protein domain of unknown function; Region: IDEAL; smart00914 358681007526 Protein of unknown function (DUF2487); Region: DUF2487; pfam10673 358681007527 Rieske Fe-S protein [Energy production and conversion]; Region: QcrA; COG0723 358681007528 Cytochrome B6-F complex Fe-S subunit; Region: CytB6-F_Fe-S; pfam08802 358681007529 Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cd03467 358681007530 iron-sulfur cluster [ion binding]; other site 358681007531 [2Fe-2S] cluster binding site [ion binding]; other site 358681007532 Cytochrome b subunit of the bc complex [Energy production and conversion]; Region: QcrB; COG1290 358681007533 Cytochrome b (N-terminus)/b6/petB: Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria; Region: Cytochrome_b_N; cd00284 358681007534 interchain domain interface [polypeptide binding]; other site 358681007535 intrachain domain interface; other site 358681007536 heme bH binding site [chemical binding]; other site 358681007537 Qi binding site; other site 358681007538 heme bL binding site [chemical binding]; other site 358681007539 Qo binding site; other site 358681007540 Cytochrome b(C-terminus)/b6/petD: Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria; Region: cytochrome_b_C; cl00193 358681007541 interchain domain interface [polypeptide binding]; other site 358681007542 intrachain domain interface; other site 358681007543 Qi binding site; other site 358681007544 Qo binding site; other site 358681007545 Cytochrome C oxidase, cbb3-type, subunit III; Region: Cytochrome_CBB3; pfam13442 358681007546 Protein of unknown function (DUF1405); Region: DUF1405; cl01798 358681007547 Sporulation protein YpjB (SpoYpjB); Region: Spore_YpjB; cl09800 358681007548 Uncharacterized conserved protein [Function unknown]; Region: COG1284 358681007549 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 358681007550 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 358681007551 Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; pfam10035 358681007552 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain putative pyrophosphatase YpjD from Bacillus subtilis and its bacterial homologs; Region: NTP-PPase_BsYpjD; cd11531 358681007553 homodimer interface [polypeptide binding]; other site 358681007554 metal binding site [ion binding]; metal-binding site 358681007555 dihydrodipicolinate reductase; Provisional; Region: PRK00048 358681007556 Dihydrodipicolinate reductase, N-terminus; Region: DapB_N; pfam01113 358681007557 Dihydrodipicolinate reductase, C-terminus; Region: DapB_C; pfam05173 358681007558 Methylglyoxal synthase catalyzes the enolization of dihydroxyacetone phosphate (DHAP) to produce methylglyoxal. The first part of the catalytic mechanism is believed to be similar to TIM (triosephosphate isomerase) in that both enzymes utilize DHAP to...; Region: MGS; cd01422 358681007559 active site 358681007560 dimer interfaces [polypeptide binding]; other site 358681007561 catalytic residues [active] 358681007562 bacillithiol biosynthesis deacetylase BshB1; Region: thiol_BshB1; TIGR04001 358681007563 N-acetyl-alpha-D-glucosaminyl L-malate synthase BshA; Region: thiol_BshA; TIGR03999 358681007564 This family is most closely related to the GT1 family of glycosyltransferases. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can...; Region: GT1_like_5; cd04962 358681007565 tRNA CCA-pyrophosphorylase; Provisional; Region: PRK13299 358681007566 Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398 358681007567 active site 358681007568 NTP binding site [chemical binding]; other site 358681007569 metal binding triad [ion binding]; metal-binding site 358681007570 Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627 358681007571 tRNA nucleotidyltransferase domain 2 putative; Region: tRNA_NucTran2_2; pfam13735 358681007572 Biotin operon repressor [Transcription]; Region: BirA; COG1654 358681007573 Biotin-(acetyl-CoA carboxylase) ligase [Coenzyme metabolism]; Region: BirA; COG0340 358681007574 Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; pfam03099 358681007575 Biotin protein ligase C terminal domain; Region: BPL_C; pfam02237 358681007576 Ketopantoate hydroxymethyltransferase (KPHMT) is the first enzyme in the pantothenate biosynthesis pathway. Ketopantoate hydroxymethyltransferase (KPHMT) catalyzes the first committed step in the biosynthesis of pantothenate (vitamin B5), which is a...; Region: KPHMT-like; cd06557 358681007577 oligomerization interface [polypeptide binding]; other site 358681007578 active site 358681007579 metal binding site [ion binding]; metal-binding site 358681007580 pantoate--beta-alanine ligase; Region: panC; TIGR00018 358681007581 Pantoate-beta-alanine ligase; Region: PanC; cd00560 358681007582 active site 358681007583 ATP-binding site [chemical binding]; other site 358681007584 pantoate-binding site; other site 358681007585 HXXH motif; other site 358681007586 Aspartate alpha-decarboxylase or L-aspartate 1-decarboxylase, a pyruvoyl group-dependent decarboxylase in beta-alanine production; Region: Asp_decarbox; cd06919 358681007587 tetramerization interface [polypeptide binding]; other site 358681007588 active site 358681007589 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 358681007590 TPR motif; other site 358681007591 binding surface 358681007592 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 358681007593 TPR motif; other site 358681007594 binding surface 358681007595 bifunctional ATP-dependent DNA helicase/DNA polymerase III subunit epsilon; Validated; Region: PRK08074 358681007596 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 358681007597 active site 358681007598 catalytic site [active] 358681007599 substrate binding site [chemical binding]; other site 358681007600 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 358681007601 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 358681007602 putative Mg++ binding site [ion binding]; other site 358681007603 Helicase C-terminal domain; Region: Helicase_C_2; pfam13307 358681007604 Predicted hydrolase (metallo-beta-lactamase superfamily) [General function prediction only]; Region: ComEC; COG2333 358681007605 Metallo-beta-lactamase superfamily; Region: Lactamase_B; pfam00753 358681007606 redox-sensing transcriptional repressor Rex; Provisional; Region: PRK05472 358681007607 Putative DNA-binding protein N-terminus; Region: Put_DNA-bind_N; pfam06971 358681007608 CoA binding domain; Region: CoA_binding; pfam02629 358681007609 N-ethylammeline chlorohydrolase; Provisional; Region: PRK06038 358681007610 TRZ/ATZ family contains enzymes from the atrazine degradation pathway and related hydrolases. Atrazine, a chlorinated herbizide, can be catabolized by a variety of different bacteria. The first three steps of the atrazine dehalogenation pathway are...; Region: ATZ_TRZ_like; cd01298 358681007611 active site 358681007612 putative substrate binding pocket [chemical binding]; other site 358681007613 bifunctional phosphoglucose/phosphomannose isomerase; Validated; Region: PRK08674 358681007614 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5353 358681007615 Domain of unknown function (DUF4307); Region: DUF4307; pfam14155 358681007616 ATP-dependent metalloprotease FtsH; Region: FtsH_fam; TIGR01241 358681007617 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 358681007618 Walker A motif; other site 358681007619 ATP binding site [chemical binding]; other site 358681007620 Walker B motif; other site 358681007621 arginine finger; other site 358681007622 Peptidase family M41; Region: Peptidase_M41; pfam01434 358681007623 asparaginyl-tRNA synthetase; Validated; Region: asnC; PRK03932 358681007624 AsnRS_cyto_like_N: N-terminal, anticodon recognition domain of the type found in human and Saccharomyces cerevisiae cytoplasmic asparaginyl-tRNA synthetase (AsnRS), in Brugia malayai AsnRs and, in various putative bacterial AsnRSs. This domain is a...; Region: AsnRS_cyto_like_N; cd04323 358681007625 putative dimer interface [polypeptide binding]; other site 358681007626 putative anticodon binding site; other site 358681007627 Asx tRNA synthetase (AspRS/AsnRS) class II core domain. Assignment to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs in the core domain. This family includes AsnRS as well as...; Region: AsxRS_core; cd00776 358681007628 homodimer interface [polypeptide binding]; other site 358681007629 motif 1; other site 358681007630 motif 2; other site 358681007631 active site 358681007632 motif 3; other site 358681007633 Putative primosome component and related proteins [DNA replication, recombination, and repair]; Region: DnaD; COG3935 358681007634 Replication initiation and membrane attachment; Region: DnaB_2; pfam07261 358681007635 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 358681007636 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 358681007637 dTDP-glucose pyrophosphorylase [Cell envelope biogenesis, outer membrane]; Region: RfbA; COG1209 358681007638 G1P_TT_long represents the long form of glucose-1-phosphate thymidylyltransferase; Region: G1P_TT_long; cd04189 358681007639 substrate binding site; other site 358681007640 metal-binding site 358681007641 Oligomer interface; other site 358681007642 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 358681007643 putative trimer interface [polypeptide binding]; other site 358681007644 putative CoA binding site [chemical binding]; other site 358681007645 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 358681007646 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 358681007647 active site 358681007648 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 358681007649 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 358681007650 NAD(P) binding site [chemical binding]; other site 358681007651 active site 358681007652 This is a family of GT1 glycosyltransferases found specifically in certain bacteria. amsK in Erwinia amylovora, has been reported to be involved in the biosynthesis of amylovoran, a exopolysaccharide acting as a virulence factor; Region: GT1_amsK_like; cd03799 358681007653 Glycosyltransferase Family 4; Region: Glyco_transf_4; pfam13439 358681007654 putative ADP-binding pocket [chemical binding]; other site 358681007655 Predicted UDP-glucose 6-dehydrogenase [Cell envelope biogenesis, outer membrane]; Region: Ugd; COG1004 358681007656 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 358681007657 UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984 358681007658 UDP-glucose/GDP-mannose dehydrogenase family, UDP binding domain; Region: UDPG_MGDP_dh_C; pfam03720 358681007659 oligoendopeptidase F; Region: pepF; TIGR00181 358681007660 Peptidase family M3B Oligopeptidase F (PepF); Region: M3B_PepF_3; cd09608 358681007661 active site 358681007662 Zn binding site [ion binding]; other site 358681007663 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 358681007664 HlyD family secretion protein; Region: HlyD_3; pfam13437 358681007665 Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841 358681007666 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 358681007667 putative beta-ketoacyl acyl carrier protein [ACP] reductase (BKR)-like, SDR; Region: BKR_like_SDR_like; cd05344 358681007668 putative NAD(P) binding site [chemical binding]; other site 358681007669 putative active site [active] 358681007670 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1666 358681007671 Proteins similar to Escherichia coli YajQ; Region: YajQ_like; cd11740 358681007672 AMP-binding domain protein; Validated; Region: PRK08315 358681007673 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 358681007674 Uncharacterized subfamily of fatty acid CoA ligase (FACL); Region: FACL_like_2; cd05917 358681007675 acyl-activating enzyme (AAE) consensus motif; other site 358681007676 putative AMP binding site [chemical binding]; other site 358681007677 putative active site [active] 358681007678 putative CoA binding site [chemical binding]; other site 358681007679 Acetyltransferase (GNAT) domain; Region: Acetyltransf_4; pfam13420 358681007680 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 358681007681 Coenzyme A binding pocket [chemical binding]; other site 358681007682 isopropylmalate isomerase small subunit; Provisional; Region: leuD; PRK01641 358681007683 Aconatase-like swivel domain of 3-isopropylmalate dehydratase and related uncharacterized proteins. 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate...; Region: IPMI_Swivel; cd01577 358681007684 substrate binding site [chemical binding]; other site 358681007685 3-isopropylmalate dehydratase large subunit; Reviewed; Region: PRK00402 358681007686 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate; Region: IPMI; cd01583 358681007687 substrate binding site [chemical binding]; other site 358681007688 ligand binding site [chemical binding]; other site 358681007689 Transcriptional regulator [Transcription]; Region: LysR; COG0583 358681007690 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 358681007691 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 358681007692 dimerization interface [polypeptide binding]; other site 358681007693 Sortase E (SrtE) is a membrane transpeptidase found in gram-positive bacteria that cleaves surface proteins at a cell sorting motif and catalyzes a transpeptidation reaction in which the surface protein substrate is covalently linked to peptidoglycan for...; Region: Sortase_E; cd05829 358681007694 active site 358681007695 putative catalytic site [active] 358681007696 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 358681007697 catalytic residues [active] 358681007698 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 358681007699 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 358681007700 active site 358681007701 YheC/D like ATP-grasp; Region: ATPgrasp_YheCD; pfam14398 358681007702 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 358681007703 active site 358681007704 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 358681007705 Coenzyme A binding pocket [chemical binding]; other site 358681007706 MutT homolog-1 (MTH1) is a member of the Nudix hydrolase superfamily. MTH1, the mammalian counterpart of MutT, hydrolyzes oxidized purine nucleoside triphosphates, such as 8-oxo-dGTP and 2-hydroxy-ATP, to monophosphates, thereby preventing the...; Region: MTH1; cd03427 358681007707 putative active site [active] 358681007708 nucleotide binding site [chemical binding]; other site 358681007709 nudix motif; other site 358681007710 putative metal binding site [ion binding]; other site 358681007711 D-Serine dehydratase is a pyridoxal phosphate (PLP)-dependent enzyme which catalyzes the conversion of L- or D-serine to pyruvate and ammonia. D-serine dehydratase serves as a detoxifying enzyme in most E. coli strains where D-serine is a competitive...; Region: D-Ser-dehyd; cd06447 358681007712 Pyridoxal-phosphate dependent enzyme; Region: PALP; pfam00291 358681007713 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 358681007714 catalytic residue [active] 358681007715 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 358681007716 S-adenosylmethionine binding site [chemical binding]; other site 358681007717 amidase; Provisional; Region: PRK06828 358681007718 Amidase; Region: Amidase; cl11426 358681007719 putative rhodanese-related sulfurtransferase; Provisional; Region: PRK00142 358681007720 Member of the Rhodanese Homology Domain superfamily. This CD includes Escherichia coli YceA, Bacillus subtilis YbfQ, and similar uncharacterized proteins; Region: RHOD_YceA; cd01518 358681007721 active site residue [active] 358681007722 Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557 358681007723 trimer interface [polypeptide binding]; other site 358681007724 active site 358681007725 Domain of unknown function (DUF3846); Region: DUF3846; pfam12957 358681007726 putative aminophosphonate oxidoreductase; Region: Phn_aa_oxid; TIGR03329 358681007727 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 358681007728 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 358681007729 Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531 358681007730 substrate binding pocket [chemical binding]; other site 358681007731 membrane-bound complex binding site; other site 358681007732 hinge residues; other site 358681007733 ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555 358681007734 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 358681007735 dimer interface [polypeptide binding]; other site 358681007736 conserved gate region; other site 358681007737 putative PBP binding loops; other site 358681007738 ABC-ATPase subunit interface; other site 358681007739 sulfate transport protein; Provisional; Region: cysT; CHL00187 358681007740 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 358681007741 dimer interface [polypeptide binding]; other site 358681007742 conserved gate region; other site 358681007743 putative PBP binding loops; other site 358681007744 ABC-ATPase subunit interface; other site 358681007745 ABC-type sulfate/molybdate transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: CysA; COG1118 358681007746 ATP-binding cassette domain of the sulfate transporter; Region: ABC_CysA_sulfate_importer; cd03296 358681007747 Walker A/P-loop; other site 358681007748 ATP binding site [chemical binding]; other site 358681007749 Q-loop/lid; other site 358681007750 ABC transporter signature motif; other site 358681007751 Walker B; other site 358681007752 D-loop; other site 358681007753 H-loop/switch region; other site 358681007754 TOBE-like domain; Region: TOBE_3; pfam12857 358681007755 ABC transporter ATP-binding protein; Provisional; Region: PRK15064 358681007756 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 358681007757 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 358681007758 ABC transporter; Region: ABC_tran_2; pfam12848 358681007759 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 358681007760 putative transposase OrfB; Reviewed; Region: PHA02517 358681007761 HTH-like domain; Region: HTH_21; pfam13276 358681007762 Integrase core domain; Region: rve; pfam00665 358681007763 Integrase core domain; Region: rve_3; pfam13683 358681007764 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 358681007765 Transposase; Region: HTH_Tnp_1; pfam01527 358681007766 allantoate amidohydrolase; Reviewed; Region: PRK09290 358681007767 M20 Peptidase beta-alanine synthase, an amidohydrolase; Region: M20_bAS; cd03884 358681007768 active site 358681007769 metal binding site [ion binding]; metal-binding site 358681007770 dimer interface [polypeptide binding]; other site 358681007771 Predicted amidohydrolase [General function prediction only]; Region: COG0388 358681007772 Uncharacterized subgroup of the nitrilase superfamily; some members of this subgroup have an N-terminal RimI domain (class 12 nitrilases); Region: nitrilase_Rim1_like; cd07574 358681007773 putative active site [active] 358681007774 catalytic triad [active] 358681007775 putative dimer interface [polypeptide binding]; other site 358681007776 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 358681007777 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 358681007778 Coenzyme A binding pocket [chemical binding]; other site 358681007779 PAS fold; Region: PAS; pfam00989 358681007780 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 358681007781 putative active site [active] 358681007782 heme pocket [chemical binding]; other site 358681007783 psp operon transcriptional activator PspF; Region: phageshock_pspF; TIGR02974 358681007784 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 358681007785 Walker A motif; other site 358681007786 ATP binding site [chemical binding]; other site 358681007787 Walker B motif; other site 358681007788 arginine finger; other site 358681007789 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 358681007790 cobalt transporter ATP-binding subunit; Provisional; Region: PRK13633 358681007791 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 358681007792 Walker A/P-loop; other site 358681007793 ATP binding site [chemical binding]; other site 358681007794 Q-loop/lid; other site 358681007795 ABC transporter signature motif; other site 358681007796 Walker B; other site 358681007797 D-loop; other site 358681007798 H-loop/switch region; other site 358681007799 cobalt transporter ATP-binding subunit; Provisional; Region: cbiO; PRK13637 358681007800 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 358681007801 Walker A/P-loop; other site 358681007802 ATP binding site [chemical binding]; other site 358681007803 Q-loop/lid; other site 358681007804 ABC transporter signature motif; other site 358681007805 Walker B; other site 358681007806 D-loop; other site 358681007807 H-loop/switch region; other site 358681007808 ABC-type cobalt transport system, permease component CbiQ and related transporters [Inorganic ion transport and metabolism]; Region: CbiQ; COG0619 358681007809 Predicted membrane protein [Function unknown]; Region: COG4684 358681007810 Protein of unknown function (DUF3816); Region: DUF3816; pfam12822 358681007811 nylC-like family; composed of proteins with similarity to Flavobacterium endo-type 6-aminohexanoate-oligomer hydrolase (EIII), the product of the nylon oligomer degradation gene, nylC. EIII is an amide hydrolase that catalyzes the degradation of...; Region: nylC_like; cd02252 358681007812 putative active site pocket [active] 358681007813 cleavage site 358681007814 acetylornithine deacetylase or succinyl-diaminopimelate desuccinylase; Region: DapE-ArgE; TIGR01910 358681007815 Peptidase M20 acetylornithine deacetylase/succinyl-diaminopimelate desuccinylase (ArgE/DapE)-like; Region: M20_ArgE_DapE_like; cd08659 358681007816 metal binding site [ion binding]; metal-binding site 358681007817 dimer interface [polypeptide binding]; other site 358681007818 oligoendopeptidase, pepF/M3 family; Region: M3_fam_3; TIGR02290 358681007819 Peptidase family M3B Oligopeptidase F (PepF); Region: M3B_PepF_2; cd09607 358681007820 active site 358681007821 Zn binding site [ion binding]; other site 358681007822 FOG: LysM repeat [Cell envelope biogenesis, outer membrane]; Region: LytE; COG1388 358681007823 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 358681007824 Bacterial SH3 domain; Region: SH3_3; pfam08239 358681007825 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 358681007826 NlpC/P60 family; Region: NLPC_P60; pfam00877 358681007827 Thioredoxin reductase [Posttranslational modification, protein turnover, chaperones]; Region: TrxB; COG0492 358681007828 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 358681007829 VanW like protein; Region: VanW; pfam04294 358681007830 2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179 358681007831 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; cl11421 358681007832 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 358681007833 NlpC/P60 family; Region: NLPC_P60; cl17555 358681007834 NlpC/P60 family; Region: NLPC_P60; pfam00877 358681007835 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 358681007836 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 358681007837 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 358681007838 acyl-CoA synthetase; Validated; Region: PRK06839 358681007839 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 358681007840 Bacterial Bile acid CoA ligases and similar proteins; Region: BACL_like; cd05929 358681007841 acyl-activating enzyme (AAE) consensus motif; other site 358681007842 putative AMP binding site [chemical binding]; other site 358681007843 putative active site [active] 358681007844 putative CoA binding site [chemical binding]; other site 358681007845 (R)-hydratase [(R)-specific enoyl-CoA hydratase] catalyzes the hydration of trans-2-enoyl CoA to (R)-3-hydroxyacyl-CoA as part of the PHA (polyhydroxyalkanoate) biosynthetic pathway. (R)-hydratase contains a hot-dog fold similar to those of thioesterase...; Region: R_hydratase; cd03449 358681007846 dimer interaction site [polypeptide binding]; other site 358681007847 substrate-binding tunnel; other site 358681007848 active site 358681007849 catalytic site [active] 358681007850 substrate binding site [chemical binding]; other site 358681007851 hypothetical protein; Validated; Region: PRK06840 358681007852 "initiating" condensing enzymes are a subclass of decarboxylating condensing enzymes, including beta-ketoacyl [ACP] synthase, type III and polyketide synthases, type III, which include chalcone synthase and related enzymes. They are...; Region: init_cond_enzymes; cd00827 358681007853 dimer interface [polypeptide binding]; other site 358681007854 active site 358681007855 Periplasmic binding protein; Region: Peripla_BP_6; pfam13458 358681007856 Periplasmic solute-binding domain of active transport proteins found in gram-negative and gram-positive bacteria; Region: PBP1_SBP_like_2; cd06328 358681007857 putative ligand binding site [chemical binding]; other site 358681007858 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411 358681007859 ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219 358681007860 Walker A/P-loop; other site 358681007861 ATP binding site [chemical binding]; other site 358681007862 Q-loop/lid; other site 358681007863 ABC transporter signature motif; other site 358681007864 Walker B; other site 358681007865 D-loop; other site 358681007866 H-loop/switch region; other site 358681007867 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410 358681007868 ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224 358681007869 Walker A/P-loop; other site 358681007870 ATP binding site [chemical binding]; other site 358681007871 Q-loop/lid; other site 358681007872 ABC transporter signature motif; other site 358681007873 Walker B; other site 358681007874 D-loop; other site 358681007875 H-loop/switch region; other site 358681007876 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 358681007877 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 358681007878 TM-ABC transporter signature motif; other site 358681007879 ABC-type branched-chain amino acid transport system, permease component [Amino acid transport and metabolism]; Region: LivM; COG4177 358681007880 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 358681007881 TM-ABC transporter signature motif; other site 358681007882 Acyl-coenzyme A synthetases/AMP-(fatty) acid ligases [Lipid metabolism]; Region: Acs; COG0365 358681007883 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 358681007884 acyl-activating enzyme (AAE) consensus motif; other site 358681007885 AMP binding site [chemical binding]; other site 358681007886 active site 358681007887 CoA binding site [chemical binding]; other site 358681007888 glycosyltransferase; Provisional; Region: PRK13481 358681007889 Transglycosylase; Region: Transgly; pfam00912 358681007890 Protein of unknown function (DUF2642); Region: DUF2642; pfam10842 358681007891 Manganese catalase, ferritin-like diiron-binding domain; Region: Mn_catalase; cd01051 358681007892 dimanganese center [ion binding]; other site 358681007893 site-specific tyrosine recombinase XerS; Reviewed; Region: xerS; PRK05084 358681007894 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 358681007895 active site 358681007896 DNA binding site [nucleotide binding] 358681007897 Int/Topo IB signature motif; other site 358681007898 Thioredoxin (TRX)-like [2Fe-2S] Ferredoxin (Fd) family; composed of [2Fe-2S] Fds with a TRX fold (TRX-like Fds) and proteins containing domains similar to TRX-like Fd including formate dehydrogenases, NAD-reducing hydrogenases and the subunit E of NADH:...; Region: TRX_Fd_family; cd02980 358681007899 dimer interface [polypeptide binding]; other site 358681007900 [2Fe-2S] cluster binding site [ion binding]; other site 358681007901 pyridoxal phosphate-dependent acyltransferase, putative; Region: gly_Cac_T_rel; TIGR01825 358681007902 KBL_like; this family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to serine palmitoyltransferase (SPT), 5-aminolevulinate synthase (ALAS); Region: KBL_like; cd06454 358681007903 substrate-cofactor binding pocket; other site 358681007904 pyridoxal 5'-phosphate binding site [chemical binding]; other site 358681007905 catalytic residue [active] 358681007906 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 358681007907 L-threonine dehydrogenase, extended (e) SDRs; Region: TDH_SDR_e; cd05272 358681007908 NAD binding site [chemical binding]; other site 358681007909 homodimer interface [polypeptide binding]; other site 358681007910 active site 358681007911 putative substrate binding site [chemical binding]; other site 358681007912 Coat F domain; Region: Coat_F; pfam07875 358681007913 S-layer homology domain; Region: SLH; pfam00395 358681007914 S-layer homology domain; Region: SLH; pfam00395 358681007915 The GH18 (glycosyl hydrolase, family 18) type II chitinases hydrolyze chitin, an abundant polymer of beta-1,4-linked N-acetylglucosamine (GlcNAc) which is a major component of the cell wall of fungi and the exoskeleton of arthropods. Chitinases have...; Region: GH18_chitinase-like; cl10447 358681007916 active site 358681007917 putative bacillithiol system oxidoreductase, YpdA family; Region: Bthiol_YpdA; TIGR04018 358681007918 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738 358681007919 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 358681007920 Protein Kinase C Interacting protein related (PKCI): PKCI and related proteins belong to the ubiquitous HIT family of hydrolases that act on alpha-phosphates of ribonucleotides. The members of this subgroup have a conserved HxHxHxx motif (x is a...; Region: PKCI_related; cd01276 358681007921 nucleotide binding site/active site [active] 358681007922 HIT family signature motif; other site 358681007923 catalytic residue [active] 358681007924 Acyl-CoA thioester hydrolase/BAAT N-terminal region; Region: Bile_Hydr_Trans; pfam04775 358681007925 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 358681007926 BAAT / Acyl-CoA thioester hydrolase C terminal; Region: BAAT_C; pfam08840 358681007927 Predicted transcriptional regulator [Transcription]; Region: COG1959 358681007928 Transcriptional regulator; Region: Rrf2; pfam02082 358681007929 Adenosine deaminase [Nucleotide transport and metabolism]; Region: Ada; COG2169 358681007930 Metal binding domain of Ada; Region: Ada_Zn_binding; pfam02805 358681007931 Methylated DNA-protein cysteine methyltransferase [DNA replication, recombination, and repair]; Region: Ada; COG0350 358681007932 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 358681007933 DNA binding site [nucleotide binding] 358681007934 active site 358681007935 Response regulator receiver domain; Region: Response_reg; pfam00072 358681007936 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 358681007937 active site 358681007938 phosphorylation site [posttranslational modification] 358681007939 intermolecular recognition site; other site 358681007940 dimerization interface [polypeptide binding]; other site 358681007941 ethanolamine ammonia lyase large subunit; Provisional; Region: PRK15067 358681007942 Ethanolamine ammonia lyase large subunit (EutB); Region: EutB; pfam06751 358681007943 ethanolamine ammonia-lyase small subunit; Provisional; Region: PRK05465 358681007944 Predicted transcriptional regulator [Transcription]; Region: COG2378 358681007945 HTH domain; Region: HTH_11; pfam08279 358681007946 WYL domain; Region: WYL; pfam13280 358681007947 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3708 358681007948 Uncharacterized conserved protein [Function unknown]; Region: COG0398 358681007949 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 358681007950 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 358681007951 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 358681007952 active site 358681007953 phosphorylation site [posttranslational modification] 358681007954 intermolecular recognition site; other site 358681007955 dimerization interface [polypeptide binding]; other site 358681007956 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 358681007957 DNA binding site [nucleotide binding] 358681007958 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 358681007959 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 358681007960 dimerization interface [polypeptide binding]; other site 358681007961 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 358681007962 dimer interface [polypeptide binding]; other site 358681007963 phosphorylation site [posttranslational modification] 358681007964 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 358681007965 ATP binding site [chemical binding]; other site 358681007966 Mg2+ binding site [ion binding]; other site 358681007967 G-X-G motif; other site 358681007968 Zinc carboxypeptidase; Region: Peptidase_M14; pfam00246 358681007969 active site 358681007970 Zn binding site [ion binding]; other site 358681007971 Zn binding site [ion binding]; other site 358681007972 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 358681007973 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_15; cd08492 358681007974 Histidine kinase-like ATPases; Region: HATPase_c; smart00387 358681007975 G-X-G motif; other site 358681007976 Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280 358681007977 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 358681007978 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 358681007979 putative substrate translocation pore; other site 358681007980 luciferase-type oxidoreductase, BA3436 family; Region: lucif_BA3436; TIGR03571 358681007981 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 358681007982 Predicted transcriptional regulators [Transcription]; Region: COG1733 358681007983 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 358681007984 alcohol dehydrogenase and quinone reductase-like medium chain degydrogenases/reductases; Region: MDR_like_2; cd05289 358681007985 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 358681007986 putative NAD(P) binding site [chemical binding]; other site 358681007987 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 358681007988 drug efflux system protein MdtG; Provisional; Region: PRK09874 358681007989 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 358681007990 putative substrate translocation pore; other site 358681007991 Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function; Region: STAS_SulP_like_sulfate_transporter; cd07042 358681007992 Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659 358681007993 potential frameshift: common BLAST hit: gi|15612977|ref|NP_241280.1| sulfate permease 358681007994 Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659 358681007995 Sulfate transporter family; Region: Sulfate_transp; pfam00916 358681007996 Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659 358681007997 Sulfate transporter N-terminal domain with GLY motif; Region: Sulfate_tra_GLY; pfam13792 358681007998 Sulfate transporter family; Region: Sulfate_transp; pfam00916 358681007999 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 358681008000 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 358681008001 ATP-binding cassette domain of the bacterial lipid flippase and related proteins, subfamily C; Region: ABCC_MsbA; cd03251 358681008002 Walker A/P-loop; other site 358681008003 ATP binding site [chemical binding]; other site 358681008004 Q-loop/lid; other site 358681008005 ABC transporter signature motif; other site 358681008006 Walker B; other site 358681008007 D-loop; other site 358681008008 H-loop/switch region; other site 358681008009 Uncharacterized Fe-S protein [General function prediction only]; Region: FhuF; COG4114 358681008010 FhuF 2Fe-2S C-terminal domain; Region: FhuF_C; pfam11575 358681008011 transcriptional activator SprB; Provisional; Region: PRK15320 358681008012 SNF2 Helicase protein; Region: DUF3670; pfam12419 358681008013 SNF2 family N-terminal domain; Region: SNF2_N; pfam00176 358681008014 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 358681008015 ATP binding site [chemical binding]; other site 358681008016 putative Mg++ binding site [ion binding]; other site 358681008017 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 358681008018 nucleotide binding region [chemical binding]; other site 358681008019 ATP-binding site [chemical binding]; other site 358681008020 SWIM zinc finger; Region: SWIM; pfam04434 358681008021 phosphonate utilization associated putative membrane protein; Region: phn_DUF6; TIGR03340 358681008022 Small Multidrug Resistance protein; Region: Multi_Drug_Res; cl00910 358681008023 EamA-like transporter family; Region: EamA; cl17759 358681008024 Uncharacterized conserved protein [Function unknown]; Region: COG1284 358681008025 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 358681008026 Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; pfam10035 358681008027 helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346 358681008028 Transcriptional regulator [Transcription]; Region: IclR; COG1414 358681008029 Bacterial transcriptional regulator; Region: IclR; pfam01614 358681008030 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 358681008031 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 358681008032 Walker A/P-loop; other site 358681008033 ATP binding site [chemical binding]; other site 358681008034 Q-loop/lid; other site 358681008035 ABC transporter signature motif; other site 358681008036 Walker B; other site 358681008037 D-loop; other site 358681008038 H-loop/switch region; other site 358681008039 oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727 358681008040 dipeptide transporter ATP-binding subunit; Provisional; Region: dppF; PRK11308 358681008041 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 358681008042 Walker A/P-loop; other site 358681008043 ATP binding site [chemical binding]; other site 358681008044 Q-loop/lid; other site 358681008045 ABC transporter signature motif; other site 358681008046 Walker B; other site 358681008047 D-loop; other site 358681008048 H-loop/switch region; other site 358681008049 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 358681008050 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 358681008051 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cd00995 358681008052 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 358681008053 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 358681008054 dimer interface [polypeptide binding]; other site 358681008055 conserved gate region; other site 358681008056 putative PBP binding loops; other site 358681008057 ABC-ATPase subunit interface; other site 358681008058 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 358681008059 N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911 358681008060 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 358681008061 dimer interface [polypeptide binding]; other site 358681008062 conserved gate region; other site 358681008063 putative PBP binding loops; other site 358681008064 ABC-ATPase subunit interface; other site 358681008065 M14 family of metallocarboxypeptidases and related proteins; Region: Peptidase_M14_like; cl11393 358681008066 M14 family of metallocarboxypeptidases and related proteins; Region: Peptidase_M14_like; cl11393 358681008067 active site 358681008068 Zn binding site [ion binding]; other site 358681008069 Zn binding site [ion binding]; other site 358681008070 Pyroglutamyl peptidase (PGP) type I, also known as pyrrolidone carboxyl peptidase (pcp) type I: Enzymes responsible for cleaving pyroglutamate (pGlu) from the N-terminal end of specialized proteins. The N-terminal pGlu protects these proteins from...; Region: Peptidase_C15; cd00501 358681008071 putative substrate binding pocket [chemical binding]; other site 358681008072 AC domain interface; other site 358681008073 catalytic triad [active] 358681008074 AB domain interface; other site 358681008075 interchain disulfide; other site 358681008076 Allophanate hydrolase subunit 1; Region: AHS1; pfam02682 358681008077 Allophanate hydrolase subunit 1 [Amino acid transport and metabolism]; Region: DUR1; COG2049 358681008078 Allophanate hydrolase subunit 2 [Amino acid transport and metabolism]; Region: DUR1; COG1984 358681008079 LamB/YcsF family of lactam utilization protein; Region: LamB_YcsF_like; cd10787 358681008080 putative active site [active] 358681008081 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 358681008082 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 358681008083 WHG domain; Region: WHG; pfam13305 358681008084 Gluconolactonase [Carbohydrate transport and metabolism]; Region: COG3386 358681008085 Strictosidine synthase; Region: Str_synth; pfam03088 358681008086 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 358681008087 Bacterial membrane-spanning protein N-terminus; Region: YojJ; pfam10372 358681008088 Uncharacterized conserved protein [Function unknown]; Region: COG1624 358681008089 DisA bacterial checkpoint controller nucleotide-binding; Region: DisA_N; pfam02457 358681008090 Thermophilic metalloprotease (M29); Region: Peptidase_M29; pfam02073 358681008091 Leucyl aminopeptidase (aminopeptidase T) [Amino acid transport and metabolism]; Region: AmpS; COG2309 358681008092 oligoendopeptidase F; Region: pepF; TIGR00181 358681008093 Peptidase family M3B Oligopeptidase F (PepF); Region: M3B_PepF_4; cd09609 358681008094 active site 358681008095 Zn binding site [ion binding]; other site 358681008096 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 358681008097 DNA binding site [nucleotide binding] 358681008098 active site 358681008099 conserved hypothetical protein; Region: lin0512_fam; TIGR02058 358681008100 Rad3-related DNA helicases [Transcription / DNA replication, recombination, and repair]; Region: DinG; COG1199 358681008101 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 358681008102 Helicase C-terminal domain; Region: Helicase_C_2; pfam13307 358681008103 Putative multicopper oxidases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: SufI; COG2132 358681008104 Multicopper oxidase; Region: Cu-oxidase_3; pfam07732 358681008105 Multicopper oxidase; Region: Cu-oxidase; pfam00394 358681008106 Multicopper oxidase; Region: Cu-oxidase_2; pfam07731 358681008107 Predicted acyltransferases [Lipid metabolism]; Region: COG1835 358681008108 Periplasmic protein TonB, links inner and outer membranes [Cell envelope biogenesis, outer membrane]; Region: TonB; COG0810 358681008109 yrhL-like subfamily of SGNH-hydrolases, a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase_yrhL_like; cd01840 358681008110 catalytic triad [active] 358681008111 catalytic triad [active] 358681008112 oxyanion hole [active] 358681008113 EamA-like transporter family; Region: EamA; pfam00892 358681008114 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 358681008115 EamA-like transporter family; Region: EamA; pfam00892 358681008116 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 358681008117 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 358681008118 Coenzyme A binding pocket [chemical binding]; other site 358681008119 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312 358681008120 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 358681008121 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 358681008122 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 358681008123 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 358681008124 dimer interface [polypeptide binding]; other site 358681008125 conserved gate region; other site 358681008126 putative PBP binding loops; other site 358681008127 ABC-ATPase subunit interface; other site 358681008128 N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911 358681008129 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 358681008130 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 358681008131 dimer interface [polypeptide binding]; other site 358681008132 conserved gate region; other site 358681008133 putative PBP binding loops; other site 358681008134 ABC-ATPase subunit interface; other site 358681008135 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 358681008136 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 358681008137 Walker A/P-loop; other site 358681008138 ATP binding site [chemical binding]; other site 358681008139 Q-loop/lid; other site 358681008140 ABC transporter signature motif; other site 358681008141 Walker B; other site 358681008142 D-loop; other site 358681008143 H-loop/switch region; other site 358681008144 oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727 358681008145 oligopeptide ABC transporter ATP-binding protein OppF; Provisional; Region: PRK15079 358681008146 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 358681008147 Walker A/P-loop; other site 358681008148 ATP binding site [chemical binding]; other site 358681008149 Q-loop/lid; other site 358681008150 ABC transporter signature motif; other site 358681008151 Walker B; other site 358681008152 D-loop; other site 358681008153 H-loop/switch region; other site 358681008154 oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727 358681008155 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 358681008156 The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504 358681008157 peptide binding site [polypeptide binding]; other site 358681008158 Dipeptidyl aminopeptidases/acylaminoacyl-peptidases [Amino acid transport and metabolism]; Region: DAP2; COG1506 358681008159 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 358681008160 Dipeptidyl aminopeptidases/acylaminoacyl-peptidases [Amino acid transport and metabolism]; Region: DAP2; COG1506 358681008161 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 358681008162 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 358681008163 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 358681008164 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 358681008165 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 358681008166 Uncharacterized M20 Dipeptidases; Region: M20_dipept_like_4; cd05681 358681008167 hypothetical protein; Provisional; Region: PRK06446 358681008168 metal binding site [ion binding]; metal-binding site 358681008169 dimer interface [polypeptide binding]; other site 358681008170 methionine sulfoxide reductase A; Provisional; Region: PRK14054 358681008171 methionine sulfoxide reductase B; Provisional; Region: PRK00222 358681008172 SelR domain; Region: SelR; pfam01641 358681008173 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 358681008174 The substrate-binding component of an uncharacterized ABC-type peptide import system Ylib contains the type 2 periplasmic binding fold; Region: PBP2_Ylib_like; cd08499 358681008175 D-alanyl-D-alanine carboxypeptidase [Cell envelope biogenesis, outer membrane]; Region: VanY; COG1876 358681008176 D-alanyl-D-alanine carboxypeptidase; Region: VanY; pfam02557 358681008177 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 358681008178 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 358681008179 YsiA-like protein, C-terminal region; Region: TetR_C_4; pfam08359 358681008180 acetyl-CoA carboxylase biotin carboxyl carrier protein subunit; Validated; Region: PRK06302 358681008181 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 358681008182 carboxyltransferase (CT) interaction site; other site 358681008183 biotinylation site [posttranslational modification]; other site 358681008184 Coenzyme B12-dependent-methylmalonyl coenzyme A (CoA) mutase (MCM) family, Beta subunit-like subfamily; contains bacterial proteins similar to the beta subunit of MCMs from Propionbacterium shermanni and Streptomyces cinnamonensis, which are alpha/beta...; Region: MM_CoA_mutase_beta; cd03677 358681008185 heterodimer interface [polypeptide binding]; other site 358681008186 substrate interaction site [chemical binding]; other site 358681008187 methylmalonyl-CoA mutase; Reviewed; Region: PRK09426 358681008188 Coenzyme B12-dependent-methylmalonyl coenzyme A (CoA) mutase (MCM) family, Alpha subunit-like subfamily; contains proteins similar to the alpha subunit of Propionbacterium shermanni MCM, as well as human and E. coli MCM. Members of this subfamily contain...; Region: MM_CoA_mutase_alpha_like; cd03679 358681008189 active site 358681008190 substrate binding site [chemical binding]; other site 358681008191 coenzyme B12 binding site [chemical binding]; other site 358681008192 methylmalonyl CoA mutase B12 binding domain. This domain binds to B12 (adenosylcobamide), which initiates the conversion of succinyl CoA and methylmalonyl CoA by forming an adenosyl radical, which then undergoes a rearrangement exchanging a hydrogen atom...; Region: MM_CoA_mut_B12_BD; cd02071 358681008193 B12 binding site [chemical binding]; other site 358681008194 cobalt ligand [ion binding]; other site 358681008195 membrane ATPase/protein kinase; Provisional; Region: PRK09435 358681008196 The function of this protein family is unkown. The protein sequences are similar to the ArgK protein in E. coli. ArgK protein is a membrane ATPase which is required for transporting arginine, ornithine and lysine into the cells by the arginine and...; Region: ArgK-like; cd03114 358681008197 Walker A; other site 358681008198 methylmalonyl-CoA decarboxylase alpha subunit; Region: mmdA; TIGR01117 358681008199 malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682 358681008200 Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; cl17345 358681008201 acetyl-CoA carboxylase biotin carboxyl carrier protein subunit; Validated; Region: PRK06302 358681008202 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 358681008203 carboxyltransferase (CT) interaction site; other site 358681008204 biotinylation site [posttranslational modification]; other site 358681008205 acetyl-CoA carboxylase biotin carboxylase subunit; Validated; Region: PRK08591 358681008206 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 358681008207 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786 358681008208 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 358681008209 Predicted transcriptional regulators [Transcription]; Region: COG1378 358681008210 Sugar-specific transcriptional regulator TrmB; Region: TrmB; pfam01978 358681008211 Middle phospholipase D-like domain of the transcriptional regulator TrmB and similar proteins; Region: PLDc_like_TrmB_middle; cd09124 358681008212 C-terminal domain interface [polypeptide binding]; other site 358681008213 sugar binding site [chemical binding]; other site 358681008214 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 358681008215 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 358681008216 Novel bacterial esterase that cleaves esters on halogenated cyclic compounds; Region: Esterase_713_like; cl17303 358681008217 Domain of unknown function (DUF4274); Region: DUF4274; pfam14096 358681008218 Fucose permease [Carbohydrate transport and metabolism]; Region: FucP; COG0738 358681008219 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 358681008220 putative substrate translocation pore; other site 358681008221 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 358681008222 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 358681008223 protoheme IX farnesyltransferase; Provisional; Region: PRK04375 358681008224 UbiA prenyltransferase family; Region: UbiA; pfam01040 358681008225 putative thiazole-containing bacteriocin maturation protein; Region: ocin_ThiF_like; TIGR03693 358681008226 bacteriocin biosynthesis cyclodehydratase domain; Region: cyclo_dehyd_2; TIGR03882 358681008227 YcaO-like family; Region: YcaO; pfam02624 358681008228 thiazole/oxazole-forming peptide maturase, SagD family component; Region: TOMM_cyclo_SagD; TIGR03604 358681008229 This family is the oxydase domain of NRPS (non-ribosomal peptide synthetase) and other proteins that modify polypeptides by cyclizing a thioester to form a ring. These include epoB, part of the epothilone biosynthesis pathway; tubD, part of the tubulysin...; Region: mcbC-like_oxidoreductase; cd02142 358681008230 NADPH bind site [chemical binding]; other site 358681008231 putative FMN binding site [chemical binding]; other site 358681008232 This family is the oxydase domain of NRPS (non-ribosomal peptide synthetase) and other proteins that modify polypeptides by cyclizing a thioester to form a ring. These include epoB, part of the epothilone biosynthesis pathway; tubD, part of the tubulysin...; Region: mcbC-like_oxidoreductase; cd02142 358681008233 putative FMN binding site [chemical binding]; other site 358681008234 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 358681008235 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 358681008236 Coenzyme A binding pocket [chemical binding]; other site 358681008237 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 358681008238 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 358681008239 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 358681008240 SNARE associated Golgi protein; Region: SNARE_assoc; cl00429 358681008241 N-ethylammeline chlorohydrolase; Provisional; Region: PRK07228 358681008242 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 358681008243 active site 358681008244 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 358681008245 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 358681008246 Walker A/P-loop; other site 358681008247 ATP binding site [chemical binding]; other site 358681008248 Q-loop/lid; other site 358681008249 ABC transporter signature motif; other site 358681008250 Walker B; other site 358681008251 D-loop; other site 358681008252 H-loop/switch region; other site 358681008253 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 358681008254 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 358681008255 dimer interface [polypeptide binding]; other site 358681008256 conserved gate region; other site 358681008257 ABC-ATPase subunit interface; other site 358681008258 NMT1-like family; Region: NMT1_2; pfam13379 358681008259 ABC transporter, substrate-binding protein, aliphatic sulfonates family; Region: SsuA_fam; TIGR01728 358681008260 tryptophan 2,3-dioxygenase; Region: trp_2_3_diox; TIGR03036 358681008261 MoxR-like ATPases [General function prediction only]; Region: COG0714 358681008262 AAA domain (dynein-related subfamily); Region: AAA_5; pfam07728 358681008263 VWA domain containing CoxE-like protein; Region: VWA_CoxE; pfam05762 358681008264 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057 358681008265 metal ion-dependent adhesion site (MIDAS); other site 358681008266 Domain of unknown function (DUF4132); Region: DUF4132; pfam13569 358681008267 The substrate-binding component of an uncharacterized ABC-type peptide import system Ylib contains the type 2 periplasmic binding fold; Region: PBP2_Ylib_like; cd08499 358681008268 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 358681008269 This CD includes cysteinyl-tRNA(Pro) deacylases from Haemophilus influenzae and Escherichia coli and other related bacterial proteins. These trans-acting, single-domain proteins are homologs of ProX and also the cis-acting prolyl-tRNA synthetase (ProRS)...; Region: YbaK_deacylase; cd00002 358681008270 putative deacylase active site [active] 358681008271 Arabinose-binding domain of AraC transcription regulator, N-term; Region: Arabinose_bd; pfam12625 358681008272 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 358681008273 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 358681008274 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: FabG; COG1028 358681008275 classical (c) SDRs; Region: SDR_c; cd05233 358681008276 NAD(P) binding site [chemical binding]; other site 358681008277 active site 358681008278 Transcriptional regulator [Transcription]; Region: LysR; COG0583 358681008279 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 358681008280 The substrate binding domain of LysR-type transcriptional regulator GltC, which activates gltA expression of glutamate synthase operon, contains type 2 periplasmic binding fold; Region: PBP2_GltC_like; cd08434 358681008281 putative dimerization interface [polypeptide binding]; other site 358681008282 glutamate synthase subunit alpha; Provisional; Region: gltB; PRK11750 358681008283 Glutamine amidotransferases class-II (Gn-AT), glutamate synthase (GltS)-type. GltS is a homodimer that synthesizes L-glutamate from 2-oxoglutarate and L-glutamine, an important step in ammonia assimilation in bacteria, cyanobacteria and plants. The...; Region: GltS; cd00713 358681008284 active site 358681008285 dimer interface [polypeptide binding]; other site 358681008286 Glutamate synthase central domain; Region: Glu_syn_central; pfam04898 358681008287 Glutamate synthase (GltS) FMN-binding domain. GltS is a complex iron-sulfur flavoprotein that catalyzes the reductive synthesis of L-glutamate from 2-oxoglutarate and L-glutamine via intramolecular channelling of ammonia, a reaction in the plant, yeast...; Region: GltS_FMN; cd02808 358681008288 active site 358681008289 FMN binding site [chemical binding]; other site 358681008290 substrate binding site [chemical binding]; other site 358681008291 3Fe-4S cluster binding site [ion binding]; other site 358681008292 gltb_C. This domain is found at the C-terminus of the large subunit (gltB) of glutamate synthase (GltS). GltS encodes a complex iron-sulfur flavoprotein that catalyzes the synthesis of L-glutamate from L-glutamine and 2-oxoglutarate. It requires the...; Region: gltB_C; cd00982 358681008293 domain interface; other site 358681008294 Domain of unknown function (DUF1877); Region: DUF1877; pfam08974 358681008295 fructuronate transporter; Provisional; Region: PRK10034; cl15264 358681008296 GntP family permease; Region: GntP_permease; pfam02447 358681008297 gluconate kinase, FGGY type; Region: gntK_FGGY; TIGR01314 358681008298 Gluconate kinases; a subfamily of the FGGY family of carbohydrate kinases; Region: FGGY_GntK; cd07770 358681008299 N- and C-terminal domain interface [polypeptide binding]; other site 358681008300 active site 358681008301 catalytic site [active] 358681008302 metal binding site [ion binding]; metal-binding site 358681008303 carbohydrate binding site [chemical binding]; other site 358681008304 ATP binding site [chemical binding]; other site 358681008305 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 358681008306 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 358681008307 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 358681008308 putative active site [active] 358681008309 Predicted 6-phosphogluconate dehydrogenase [Carbohydrate transport and metabolism]; Region: Gnd; COG1023 358681008310 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 358681008311 3-hydroxybutyryl-CoA dehydratase; Validated; Region: PRK05809 358681008312 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 358681008313 substrate binding site [chemical binding]; other site 358681008314 oxyanion hole (OAH) forming residues; other site 358681008315 trimer interface [polypeptide binding]; other site 358681008316 First Helix-Turn-Helix DNA binding domain of the regulatory protein TioE; Region: HTH_TioE_rpt1; cd04772 358681008317 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 358681008318 DNA binding residues [nucleotide binding] 358681008319 putative dimer interface [polypeptide binding]; other site 358681008320 Second Helix-Turn-Helix DNA binding domain of the regulatory protein TioE; Region: HTH_TioE_rpt2; cd04773 358681008321 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 358681008322 DNA binding residues [nucleotide binding] 358681008323 putative dimer interface [polypeptide binding]; other site 358681008324 Methyltransferase domain; Region: Methyltransf_31; pfam13847 358681008325 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 358681008326 S-adenosylmethionine binding site [chemical binding]; other site 358681008327 AAA domain; Region: AAA_33; pfam13671 358681008328 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 358681008329 active site 358681008330 metal binding site [ion binding]; metal-binding site 358681008331 Adenylation domain of proteins similar to ATP-dependent polynucleotide ligases; Region: Adenylation_DNA_ligase_like; cl12015 358681008332 Na+/alanine symporter [Amino acid transport and metabolism]; Region: AlsT; COG1115 358681008333 amino acid carrier protein; Region: agcS; TIGR00835 358681008334 glutaminase; Reviewed; Region: PRK12357 358681008335 Glutaminase [Amino acid transport and metabolism]; Region: GlsA; COG2066 358681008336 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 358681008337 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 358681008338 ATP binding site [chemical binding]; other site 358681008339 Mg2+ binding site [ion binding]; other site 358681008340 G-X-G motif; other site 358681008341 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 358681008342 Response regulator receiver domain; Region: Response_reg; pfam00072 358681008343 active site 358681008344 phosphorylation site [posttranslational modification] 358681008345 intermolecular recognition site; other site 358681008346 dimerization interface [polypeptide binding]; other site 358681008347 YcbB domain; Region: YcbB; pfam08664 358681008348 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 358681008349 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 358681008350 Novel bacterial esterase that cleaves esters on halogenated cyclic compounds; Region: Esterase_713_like; cl17303 358681008351 catalytic site [active] 358681008352 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 358681008353 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 358681008354 Transcriptional regulators [Transcription]; Region: GntR; COG1802 358681008355 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 358681008356 DNA-binding site [nucleotide binding]; DNA binding site 358681008357 FCD domain; Region: FCD; pfam07729 358681008358 Glycine/serine hydroxymethyltransferase [Amino acid transport and metabolism]; Region: GlyA; COG0112 358681008359 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 358681008360 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 358681008361 catalytic residue [active] 358681008362 MarR family; Region: MarR_2; pfam12802 358681008363 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 358681008364 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 358681008365 NAD(P) binding site [chemical binding]; other site 358681008366 active site 358681008367 Transcriptional regulators [Transcription]; Region: PurR; COG1609 358681008368 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 358681008369 DNA binding site [nucleotide binding] 358681008370 domain linker motif; other site 358681008371 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 358681008372 dimerization interface [polypeptide binding]; other site 358681008373 ligand binding site [chemical binding]; other site 358681008374 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 358681008375 AP endonuclease family 2 C terminus; Region: AP_endonuc_2_N; pfam07582 358681008376 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 358681008377 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 358681008378 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 358681008379 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 358681008380 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 358681008381 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 358681008382 ABC-type sugar transport systems, permease components [Carbohydrate transport and metabolism]; Region: UgpA; COG1175 358681008383 ABC-type Fe3+ transport system, permease component [Inorganic ion transport and metabolism]; Region: ThiP; COG1178 358681008384 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 358681008385 dimer interface [polypeptide binding]; other site 358681008386 conserved gate region; other site 358681008387 putative PBP binding loops; other site 358681008388 ABC-ATPase subunit interface; other site 358681008389 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 358681008390 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 358681008391 dimer interface [polypeptide binding]; other site 358681008392 conserved gate region; other site 358681008393 putative PBP binding loops; other site 358681008394 ABC-ATPase subunit interface; other site 358681008395 Putative hydrophobic ligand-binding SRPBCC domain of an uncharacterized subgroup of CalC- and Aha1-like proteins; Region: SRPBCC_CalC_Aha1-like_8; cd08901 358681008396 putative hydrophobic ligand binding site [chemical binding]; other site 358681008397 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459 358681008398 PAS fold; Region: PAS_4; pfam08448 358681008399 psp operon transcriptional activator PspF; Region: phageshock_pspF; TIGR02974 358681008400 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 358681008401 Walker A motif; other site 358681008402 ATP binding site [chemical binding]; other site 358681008403 Walker B motif; other site 358681008404 arginine finger; other site 358681008405 pyruvate dehydrogenase E1 component, alpha subunit; Region: PDH_E1_alph_x; TIGR03181 358681008406 Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000 358681008407 TPP-binding site [chemical binding]; other site 358681008408 tetramer interface [polypeptide binding]; other site 358681008409 heterodimer interface [polypeptide binding]; other site 358681008410 phosphorylation loop region [posttranslational modification] 358681008411 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit [Energy production and conversion]; Region: AcoB; COG0022 358681008412 Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036 358681008413 alpha subunit interface [polypeptide binding]; other site 358681008414 TPP binding site [chemical binding]; other site 358681008415 heterodimer interface [polypeptide binding]; other site 358681008416 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 358681008417 branched-chain alpha-keto acid dehydrogenase subunit E2; Reviewed; Region: PRK11856 358681008418 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 358681008419 E3 interaction surface; other site 358681008420 lipoyl attachment site [posttranslational modification]; other site 358681008421 e3 binding domain; Region: E3_binding; pfam02817 358681008422 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 358681008423 dihydrolipoamide dehydrogenase; Region: lipoamide_DH; TIGR01350 358681008424 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 358681008425 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 358681008426 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 358681008427 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 358681008428 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 358681008429 active site 358681008430 metal binding site [ion binding]; metal-binding site 358681008431 hypothetical protein; Provisional; Region: PRK09739 358681008432 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 358681008433 Predicted transcriptional regulators [Transcription]; Region: COG1733 358681008434 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 358681008435 dimerization interface [polypeptide binding]; other site 358681008436 putative DNA binding site [nucleotide binding]; other site 358681008437 putative Zn2+ binding site [ion binding]; other site 358681008438 Protein of unknown function (DUF1541); Region: DUF1541; pfam07563 358681008439 Protein of unknown function (DUF1541); Region: DUF1541; pfam07563 358681008440 Predicted transcriptional regulators [Transcription]; Region: COG1510 358681008441 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cl17220 358681008442 dimerization interface [polypeptide binding]; other site 358681008443 putative Zn2+ binding site [ion binding]; other site 358681008444 putative DNA binding site [nucleotide binding]; other site 358681008445 Zinc carboxypeptidase; Region: Peptidase_M14; pfam00246 358681008446 Zn binding site [ion binding]; other site 358681008447 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 358681008448 D-galactonate transporter; Region: 2A0114; TIGR00893 358681008449 putative substrate translocation pore; other site 358681008450 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 358681008451 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 358681008452 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 358681008453 DHH family; Region: DHH; pfam01368 358681008454 Predicted phosphohydrolase (DHH superfamily) [General function prediction only]; Region: COG2404 358681008455 DHHA1 domain; Region: DHHA1; pfam02272 358681008456 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 358681008457 dimerization interface [polypeptide binding]; other site 358681008458 putative DNA binding site [nucleotide binding]; other site 358681008459 putative Zn2+ binding site [ion binding]; other site 358681008460 Putative hydrophobic ligand-binding SRPBCC domain of Micromonospora echinospora CalC, human Aha1, and related proteins; Region: SRPBCC_CalC_Aha1-like; cd07814 358681008461 putative hydrophobic ligand binding site [chemical binding]; other site 358681008462 Uncharacterized conserved protein [Function unknown]; Region: COG0397 358681008463 hypothetical protein; Validated; Region: PRK00029 358681008464 AAA domain; Region: AAA_33; pfam13671 358681008465 AAA domain; Region: AAA_17; pfam13207 358681008466 CRISPR/Cas system-associated protein Cas3'' Region: Cas3''_I; cl17503 358681008467 RNA ligase; Region: RNA_ligase; pfam09414 358681008468 Suppressor of fused protein (SUFU); Region: SUFU; pfam05076 358681008469 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 358681008470 Walker A/P-loop; other site 358681008471 ATP binding site [chemical binding]; other site 358681008472 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 358681008473 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 358681008474 Walker A/P-loop; other site 358681008475 ATP binding site [chemical binding]; other site 358681008476 Q-loop/lid; other site 358681008477 ABC transporter signature motif; other site 358681008478 tyrosyl-tRNA synthetase; Provisional; Region: PRK13354 358681008479 catalytic core domain of tyrosinyl-tRNA synthetase; Region: TyrRS_core; cd00805 358681008480 active site 358681008481 HIGH motif; other site 358681008482 dimer interface [polypeptide binding]; other site 358681008483 KMSKS motif; other site 358681008484 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 358681008485 RNA binding surface [nucleotide binding]; other site 358681008486 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 358681008487 MarR family; Region: MarR_2; pfam12802 358681008488 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 358681008489 Major Facilitator Superfamily; Region: MFS_1; pfam07690 358681008490 putative substrate translocation pore; other site 358681008491 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 358681008492 amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733 358681008493 acyl-activating enzyme (AAE) consensus motif; other site 358681008494 AMP binding site [chemical binding]; other site 358681008495 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 358681008496 Condensation domain; Region: Condensation; pfam00668 358681008497 non-ribosomal peptide synthase domain TIGR01720; Region: NRPS-para261 358681008498 Condensation domain; Region: Condensation; pfam00668 358681008499 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 358681008500 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 358681008501 acyl-activating enzyme (AAE) consensus motif; other site 358681008502 AMP binding site [chemical binding]; other site 358681008503 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 358681008504 Condensation domain; Region: Condensation; pfam00668 358681008505 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 358681008506 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 358681008507 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 358681008508 acyl-activating enzyme (AAE) consensus motif; other site 358681008509 AMP binding site [chemical binding]; other site 358681008510 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 358681008511 Condensation domain; Region: Condensation; pfam00668 358681008512 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 358681008513 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 358681008514 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 358681008515 acyl-activating enzyme (AAE) consensus motif; other site 358681008516 AMP binding site [chemical binding]; other site 358681008517 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 358681008518 Condensation domain; Region: Condensation; pfam00668 358681008519 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 358681008520 non-ribosomal peptide synthase domain TIGR01720; Region: NRPS-para261 358681008521 Condensation domain; Region: Condensation; pfam00668 358681008522 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 358681008523 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 358681008524 acyl-activating enzyme (AAE) consensus motif; other site 358681008525 AMP binding site [chemical binding]; other site 358681008526 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 358681008527 Condensation domain; Region: Condensation; pfam00668 358681008528 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 358681008529 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 358681008530 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 358681008531 acyl-activating enzyme (AAE) consensus motif; other site 358681008532 AMP binding site [chemical binding]; other site 358681008533 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 358681008534 Condensation domain; Region: Condensation; pfam00668 358681008535 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 358681008536 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 358681008537 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 358681008538 acyl-activating enzyme (AAE) consensus motif; other site 358681008539 AMP binding site [chemical binding]; other site 358681008540 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 358681008541 Condensation domain; Region: Condensation; pfam00668 358681008542 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 358681008543 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 358681008544 The adenylation domain of nonribosomal peptide synthetases (NRPS), including Bacillus subtilis termination module Surfactin (SrfA-C); Region: A_NRPS_Srf_like; cd12117 358681008545 acyl-activating enzyme (AAE) consensus motif; other site 358681008546 AMP binding site [chemical binding]; other site 358681008547 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 358681008548 Condensation domain; Region: Condensation; pfam00668 358681008549 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 358681008550 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 358681008551 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 358681008552 acyl-activating enzyme (AAE) consensus motif; other site 358681008553 AMP binding site [chemical binding]; other site 358681008554 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 358681008555 enterobactin synthase subunit F; Provisional; Region: entF; PRK10252 358681008556 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 358681008557 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 358681008558 acyl-activating enzyme (AAE) consensus motif; other site 358681008559 AMP binding site [chemical binding]; other site 358681008560 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 358681008561 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 358681008562 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 358681008563 ATP-binding cassette domain of the bacterial lipid flippase and related proteins, subfamily C; Region: ABCC_MsbA; cd03251 358681008564 Walker A/P-loop; other site 358681008565 ATP binding site [chemical binding]; other site 358681008566 Q-loop/lid; other site 358681008567 ABC transporter signature motif; other site 358681008568 Walker B; other site 358681008569 D-loop; other site 358681008570 H-loop/switch region; other site 358681008571 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 358681008572 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 358681008573 ATP-binding cassette domain of the bacterial lipid flippase and related proteins, subfamily C; Region: ABCC_MsbA; cd03251 358681008574 Walker A/P-loop; other site 358681008575 ATP binding site [chemical binding]; other site 358681008576 Q-loop/lid; other site 358681008577 ABC transporter signature motif; other site 358681008578 Walker B; other site 358681008579 D-loop; other site 358681008580 H-loop/switch region; other site 358681008581 Phosphopantetheinyl transferase [Coenzyme metabolism]; Region: Sfp; COG2091 358681008582 4'-phosphopantetheinyl transferase superfamily; Region: ACPS; pfam01648 358681008583 Predicted thioesterase involved in non-ribosomal peptide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: GrsT; COG3208 358681008584 Predicted acetyltransferases and hydrolases with the alpha/beta hydrolase fold [General function prediction only]; Region: LipA; COG1075 358681008585 Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531 358681008586 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 358681008587 substrate binding pocket [chemical binding]; other site 358681008588 membrane-bound complex binding site; other site 358681008589 hinge residues; other site 358681008590 Secreted repeat of unknown function; Region: Lipoprotein_15; pfam03640 358681008591 Secreted repeat of unknown function; Region: Lipoprotein_15; pfam03640 358681008592 RNA polymerase sigma factor; Provisional; Region: PRK12519 358681008593 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 358681008594 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 358681008595 DNA binding residues [nucleotide binding] 358681008596 mycothiol system anti-sigma-R factor; Region: antisig_RsrA; cl15806 358681008597 Anti-sigma-K factor rskA; Region: RskA; pfam10099 358681008598 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 358681008599 Beta-lactamase; Region: Beta-lactamase; pfam00144 358681008600 Peptidase M55, D-aminopeptidase dipeptide-binding protein family; Region: DAP_dppA_1; cd08663 358681008601 SxDxEG motif; other site 358681008602 active site 358681008603 metal binding site [ion binding]; metal-binding site 358681008604 homopentamer interface [polypeptide binding]; other site 358681008605 S-layer homology domain; Region: SLH; pfam00395 358681008606 S-layer homology domain; Region: SLH; pfam00395 358681008607 D-alanyl-D-alanine carboxypeptidase; Region: VanY; pfam02557 358681008608 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 358681008609 NlpC/P60 family; Region: NLPC_P60; pfam00877 358681008610 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 358681008611 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 358681008612 active site 358681008613 phosphorylation site [posttranslational modification] 358681008614 intermolecular recognition site; other site 358681008615 dimerization interface [polypeptide binding]; other site 358681008616 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 358681008617 DNA binding site [nucleotide binding] 358681008618 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 358681008619 HAMP domain; Region: HAMP; pfam00672 358681008620 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 358681008621 dimer interface [polypeptide binding]; other site 358681008622 phosphorylation site [posttranslational modification] 358681008623 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 358681008624 ATP binding site [chemical binding]; other site 358681008625 Mg2+ binding site [ion binding]; other site 358681008626 G-X-G motif; other site 358681008627 DNA-binding transcriptional regulator CynR; Provisional; Region: PRK11242 358681008628 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 358681008629 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 358681008630 dimerization interface [polypeptide binding]; other site 358681008631 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2258 358681008632 MOSC domain; Region: MOSC; pfam03473 358681008633 3-alpha domain; Region: 3-alpha; pfam03475 358681008634 Mannose-6-phosphate isomerase [Carbohydrate transport and metabolism]; Region: {ManC}; COG0662 358681008635 alpha-galactosidase; Provisional; Region: PRK15076 358681008636 Glycoside Hydrolases Family 4; Alpha-glucosidases and alpha-galactosidases; Region: GH4_alpha_glucosidase_galactosidase; cd05297 358681008637 NAD binding site [chemical binding]; other site 358681008638 sugar binding site [chemical binding]; other site 358681008639 divalent metal binding site [ion binding]; other site 358681008640 putative tetramer (dimer of dimers) interface [polypeptide binding]; other site 358681008641 dimer interface [polypeptide binding]; other site 358681008642 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 358681008643 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 358681008644 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 358681008645 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 358681008646 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 358681008647 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 358681008648 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 358681008649 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 358681008650 dimer interface [polypeptide binding]; other site 358681008651 putative PBP binding loops; other site 358681008652 ABC-ATPase subunit interface; other site 358681008653 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 358681008654 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 358681008655 dimer interface [polypeptide binding]; other site 358681008656 conserved gate region; other site 358681008657 putative PBP binding loops; other site 358681008658 ABC-ATPase subunit interface; other site 358681008659 The enzymes of glycosyl hydrolase family 31 (GH31) occur in prokaryotes, eukaryotes, and archaea with a wide range of hydrolytic activities, including alpha-glucosidase (glucoamylase and sucrase-isomaltase), alpha-xylosidase, 6-alpha-glucosyltransferase; Region: GH31; cl11402 358681008660 catalytic site [active] 358681008661 PAS domain S-box; Region: sensory_box; TIGR00229 358681008662 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 358681008663 putative active site [active] 358681008664 heme pocket [chemical binding]; other site 358681008665 PAS domain S-box; Region: sensory_box; TIGR00229 358681008666 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 358681008667 putative active site [active] 358681008668 heme pocket [chemical binding]; other site 358681008669 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 358681008670 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 358681008671 putative active site [active] 358681008672 heme pocket [chemical binding]; other site 358681008673 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 358681008674 dimer interface [polypeptide binding]; other site 358681008675 phosphorylation site [posttranslational modification] 358681008676 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 358681008677 ATP binding site [chemical binding]; other site 358681008678 Mg2+ binding site [ion binding]; other site 358681008679 G-X-G motif; other site 358681008680 Predicted membrane protein [Function unknown]; Region: COG2364 358681008681 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 358681008682 MFS transport protein AraJ; Provisional; Region: PRK10091 358681008683 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 358681008684 putative substrate translocation pore; other site 358681008685 Diaminopimelate epimerase [Amino acid transport and metabolism]; Region: DapF; COG0253 358681008686 Methyltransferase domain; Region: Methyltransf_18; pfam12847 358681008687 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4408 358681008688 Uncharacterized protein conserved in bacteria (DUF2338); Region: DUF2338; pfam10100 358681008689 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 358681008690 The substrate-binding component of an ABC-type nickel import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA; cd08489 358681008691 substrate binding site [chemical binding]; other site 358681008692 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 358681008693 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 358681008694 dimer interface [polypeptide binding]; other site 358681008695 conserved gate region; other site 358681008696 putative PBP binding loops; other site 358681008697 ABC-ATPase subunit interface; other site 358681008698 N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911 358681008699 nickel ABC transporter, permease subunit NikC; Region: nickel_nikC; TIGR02790 358681008700 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 358681008701 dimer interface [polypeptide binding]; other site 358681008702 conserved gate region; other site 358681008703 putative PBP binding loops; other site 358681008704 ABC-ATPase subunit interface; other site 358681008705 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 358681008706 nickel import ATP-binding protein NikD; Region: nickel_nikD; TIGR02770 358681008707 Walker A/P-loop; other site 358681008708 ATP binding site [chemical binding]; other site 358681008709 Q-loop/lid; other site 358681008710 ABC transporter signature motif; other site 358681008711 Walker B; other site 358681008712 D-loop; other site 358681008713 H-loop/switch region; other site 358681008714 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 358681008715 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124 358681008716 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 358681008717 Walker A/P-loop; other site 358681008718 ATP binding site [chemical binding]; other site 358681008719 Q-loop/lid; other site 358681008720 ABC transporter signature motif; other site 358681008721 Walker B; other site 358681008722 D-loop; other site 358681008723 H-loop/switch region; other site 358681008724 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 358681008725 Major Facilitator Superfamily; Region: MFS_1; pfam07690 358681008726 putative substrate translocation pore; other site 358681008727 PAS domain S-box; Region: sensory_box; TIGR00229 358681008728 PAS domain; Region: PAS_8; pfam13188 358681008729 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920 358681008730 Histidine kinase; Region: HisKA_3; pfam07730 358681008731 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 358681008732 ATP binding site [chemical binding]; other site 358681008733 Mg2+ binding site [ion binding]; other site 358681008734 G-X-G motif; other site 358681008735 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 358681008736 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 358681008737 active site 358681008738 phosphorylation site [posttranslational modification] 358681008739 intermolecular recognition site; other site 358681008740 dimerization interface [polypeptide binding]; other site 358681008741 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 358681008742 DNA binding residues [nucleotide binding] 358681008743 dimerization interface [polypeptide binding]; other site 358681008744 Uncharacterized NAD(FAD)-dependent dehydrogenases [General function prediction only]; Region: HcaD; COG0446 358681008745 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 358681008746 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 358681008747 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 358681008748 active site residue [active] 358681008749 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 358681008750 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 358681008751 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 358681008752 dimer interface [polypeptide binding]; other site 358681008753 conserved gate region; other site 358681008754 putative PBP binding loops; other site 358681008755 ABC-ATPase subunit interface; other site 358681008756 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 358681008757 N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911 358681008758 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 358681008759 dimer interface [polypeptide binding]; other site 358681008760 conserved gate region; other site 358681008761 putative PBP binding loops; other site 358681008762 ABC-ATPase subunit interface; other site 358681008763 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 358681008764 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 358681008765 Walker A/P-loop; other site 358681008766 ATP binding site [chemical binding]; other site 358681008767 Q-loop/lid; other site 358681008768 ABC transporter signature motif; other site 358681008769 Walker B; other site 358681008770 D-loop; other site 358681008771 H-loop/switch region; other site 358681008772 oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727 358681008773 ABC-type oligopeptide transport system, ATPase component [Amino acid transport and metabolism]; Region: AppF; COG4608 358681008774 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 358681008775 Walker A/P-loop; other site 358681008776 ATP binding site [chemical binding]; other site 358681008777 Q-loop/lid; other site 358681008778 ABC transporter signature motif; other site 358681008779 Walker B; other site 358681008780 D-loop; other site 358681008781 H-loop/switch region; other site 358681008782 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 358681008783 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 358681008784 The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504 358681008785 peptide binding site [polypeptide binding]; other site 358681008786 proline aminopeptidase P II; Provisional; Region: PRK10879 358681008787 Aminopeptidase P, N-terminal domain; Region: AMP_N; smart01011 358681008788 Prolidase. E.C. 3.4.13.9. Also known as Xaa-Pro dipeptidase, X-Pro dipeptidase, proline dipeptidase., imidodipeptidase, peptidase D, gamma-peptidase. Catalyses hydrolysis of Xaa-Pro dipeptides; also acts on aminoacyl-hydroxyproline analogs. No action on...; Region: Prolidase; cd01087 358681008789 active site 358681008790 Escherichia coli PhnB and similar proteins; the E. coli phnB gene is found next to an operon involved in the cleavage of carbon-phosphorus bonds in unactivated alkylphosphonates; Region: PhnB_like; cd06588 358681008791 dimer interface [polypeptide binding]; other site 358681008792 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 358681008793 Predicted transcriptional regulator [Transcription]; Region: COG2378 358681008794 HTH domain; Region: HTH_11; pfam08279 358681008795 WYL domain; Region: WYL; pfam13280 358681008796 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 358681008797 non-specific DNA binding site [nucleotide binding]; other site 358681008798 salt bridge; other site 358681008799 sequence-specific DNA binding site [nucleotide binding]; other site 358681008800 Spo0E like sporulation regulatory protein; Region: SpoOE-like; pfam09388 358681008801 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 358681008802 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 358681008803 DNA-binding site [nucleotide binding]; DNA binding site 358681008804 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 358681008805 pyridoxal 5'-phosphate binding site [chemical binding]; other site 358681008806 homodimer interface [polypeptide binding]; other site 358681008807 catalytic residue [active] 358681008808 D-alanine--D-alanine ligase; Reviewed; Region: ddl; PRK01372 358681008809 D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820 358681008810 ATP-grasp domain; Region: ATP-grasp_4; cl17255 358681008811 DNA-binding transcriptional repressor PuuR; Provisional; Region: PRK09943 358681008812 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 358681008813 non-specific DNA binding site [nucleotide binding]; other site 358681008814 salt bridge; other site 358681008815 sequence-specific DNA binding site [nucleotide binding]; other site 358681008816 Cupin domain; Region: Cupin_2; pfam07883 358681008817 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 358681008818 Helix-Turn-Helix DNA binding domain of the transcription regulators TipAL, Mta, and SkgA; Region: HTH_TipAL-Mta; cd01106 358681008819 DNA binding residues [nucleotide binding] 358681008820 dimer interface [polypeptide binding]; other site 358681008821 Beta-lactamase; Region: Beta-lactamase; pfam00144 358681008822 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 358681008823 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 358681008824 Beta-lactamase; Region: Beta-lactamase; pfam00144 358681008825 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 358681008826 Walker A/P-loop; other site 358681008827 ATP binding site [chemical binding]; other site 358681008828 Q-loop/lid; other site 358681008829 Excinuclease ATPase subunit [DNA replication, recombination, and repair]; Region: UvrA; COG0178 358681008830 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 358681008831 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 358681008832 Walker A/P-loop; other site 358681008833 ATP binding site [chemical binding]; other site 358681008834 Q-loop/lid; other site 358681008835 ABC transporter signature motif; other site 358681008836 Walker B; other site 358681008837 D-loop; other site 358681008838 H-loop/switch region; other site 358681008839 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 358681008840 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 358681008841 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cd01292 358681008842 active site 358681008843 enoyl-CoA hydratase; Provisional; Region: PRK06688 358681008844 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 358681008845 substrate binding site [chemical binding]; other site 358681008846 oxyanion hole (OAH) forming residues; other site 358681008847 trimer interface [polypeptide binding]; other site 358681008848 Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318 358681008849 Uncharacterized subfamily of fatty acid CoA ligase (FACL); Region: FACL_DitJ_like; cd05934 358681008850 acyl-activating enzyme (AAE) consensus motif; other site 358681008851 putative AMP binding site [chemical binding]; other site 358681008852 putative active site [active] 358681008853 putative CoA binding site [chemical binding]; other site 358681008854 Cellulase M and related proteins [Carbohydrate transport and metabolism]; Region: FrvX; COG1363 358681008855 M42 Peptidase, Endoglucanases; Region: M42_Frv; cd05656 358681008856 oligomer interface [polypeptide binding]; other site 358681008857 active site 358681008858 metal binding site [ion binding]; metal-binding site 358681008859 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 358681008860 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_15; cd08492 358681008861 Beta-lactamase; Region: Beta-lactamase; pfam00144 358681008862 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 358681008863 Domain of unknown function (DUF3471); Region: DUF3471; pfam11954 358681008864 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 358681008865 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 358681008866 dimer interface [polypeptide binding]; other site 358681008867 conserved gate region; other site 358681008868 putative PBP binding loops; other site 358681008869 ABC-ATPase subunit interface; other site 358681008870 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 358681008871 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 358681008872 dimer interface [polypeptide binding]; other site 358681008873 conserved gate region; other site 358681008874 putative PBP binding loops; other site 358681008875 ABC-ATPase subunit interface; other site 358681008876 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 358681008877 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 358681008878 Walker A/P-loop; other site 358681008879 ATP binding site [chemical binding]; other site 358681008880 Q-loop/lid; other site 358681008881 ABC transporter signature motif; other site 358681008882 Walker B; other site 358681008883 D-loop; other site 358681008884 H-loop/switch region; other site 358681008885 oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727 358681008886 dipeptide transporter ATP-binding subunit; Provisional; Region: dppF; PRK11308 358681008887 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 358681008888 Walker A/P-loop; other site 358681008889 ATP binding site [chemical binding]; other site 358681008890 Q-loop/lid; other site 358681008891 ABC transporter signature motif; other site 358681008892 Walker B; other site 358681008893 D-loop; other site 358681008894 H-loop/switch region; other site 358681008895 oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727 358681008896 diaminopimelate epimerase; Provisional; Region: dapF; PRK00450 358681008897 Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678 358681008898 Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678 358681008899 RibD C-terminal domain; Region: RibD_C; cl17279 358681008900 Dihydrofolate reductase [Coenzyme metabolism]; Region: FolA; COG0262 358681008901 peptidase T; Region: peptidase-T; TIGR01882 358681008902 M20 Peptidase T specifically cleaves tripeptides; Region: M20_peptT; cd03892 358681008903 metal binding site [ion binding]; metal-binding site 358681008904 dimer interface [polypeptide binding]; other site 358681008905 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 358681008906 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 358681008907 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 358681008908 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 358681008909 Coenzyme A binding pocket [chemical binding]; other site 358681008910 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 358681008911 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 358681008912 DNA binding residues [nucleotide binding] 358681008913 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 358681008914 S-adenosylmethionine binding site [chemical binding]; other site 358681008915 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 358681008916 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 358681008917 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 358681008918 Coenzyme A binding pocket [chemical binding]; other site 358681008919 catalase/hydroperoxidase HPI(I); Provisional; Region: PRK15061 358681008920 N-terminal catalytic domain of catalase-peroxidases; Region: catalase_peroxidase_1; cd00649 358681008921 dimer interface [polypeptide binding]; other site 358681008922 active site 358681008923 heme binding site [chemical binding]; other site 358681008924 C-terminal non-catalytic domain of catalase-peroxidases; Region: catalase_peroxidase_2; cd08200 358681008925 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 358681008926 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 358681008927 active site 358681008928 phosphorylation site [posttranslational modification] 358681008929 intermolecular recognition site; other site 358681008930 dimerization interface [polypeptide binding]; other site 358681008931 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 358681008932 DNA binding site [nucleotide binding] 358681008933 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 358681008934 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 358681008935 dimerization interface [polypeptide binding]; other site 358681008936 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 358681008937 dimer interface [polypeptide binding]; other site 358681008938 phosphorylation site [posttranslational modification] 358681008939 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 358681008940 ATP binding site [chemical binding]; other site 358681008941 Mg2+ binding site [ion binding]; other site 358681008942 G-X-G motif; other site 358681008943 hypothetical protein; Provisional; Region: PRK06760; cl11698 358681008944 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 358681008945 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 358681008946 Walker A/P-loop; other site 358681008947 ATP binding site [chemical binding]; other site 358681008948 Q-loop/lid; other site 358681008949 ABC transporter signature motif; other site 358681008950 Walker B; other site 358681008951 D-loop; other site 358681008952 H-loop/switch region; other site 358681008953 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 358681008954 FtsX-like permease family; Region: FtsX; pfam02687 358681008955 FtsX-like permease family; Region: FtsX; pfam02687 358681008956 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 358681008957 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 358681008958 active site 358681008959 phosphorylation site [posttranslational modification] 358681008960 intermolecular recognition site; other site 358681008961 dimerization interface [polypeptide binding]; other site 358681008962 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 358681008963 DNA binding site [nucleotide binding] 358681008964 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 358681008965 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054 358681008966 dimerization interface [polypeptide binding]; other site 358681008967 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 358681008968 dimer interface [polypeptide binding]; other site 358681008969 phosphorylation site [posttranslational modification] 358681008970 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 358681008971 ATP binding site [chemical binding]; other site 358681008972 Mg2+ binding site [ion binding]; other site 358681008973 G-X-G motif; other site 358681008974 Protein of unknown function (DUF2809); Region: DUF2809; pfam10990 358681008975 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 358681008976 dimerization interface [polypeptide binding]; other site 358681008977 putative DNA binding site [nucleotide binding]; other site 358681008978 putative Zn2+ binding site [ion binding]; other site 358681008979 Protein of unknown function (DUF1648); Region: DUF1648; pfam07853 358681008980 Predicted integral membrane protein [Function unknown]; Region: COG5658 358681008981 SdpI/YhfL protein family; Region: SdpI; pfam13630 358681008982 Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841 358681008983 Protein export membrane protein; Region: SecD_SecF; cl14618 358681008984 Protein export membrane protein; Region: SecD_SecF; cl14618 358681008985 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 358681008986 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 358681008987 E3 interaction surface; other site 358681008988 HlyD family secretion protein; Region: HlyD_3; pfam13437 358681008989 Predicted thioesterase involved in non-ribosomal peptide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: GrsT; COG3208 358681008990 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 358681008991 active site 358681008992 catalytic tetrad [active] 358681008993 ABC-2 family transporter protein; Region: ABC2_membrane_2; cl17866 358681008994 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 358681008995 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 358681008996 Walker A/P-loop; other site 358681008997 ATP binding site [chemical binding]; other site 358681008998 Q-loop/lid; other site 358681008999 ABC transporter signature motif; other site 358681009000 Walker B; other site 358681009001 D-loop; other site 358681009002 H-loop/switch region; other site 358681009003 Formyltransferase, catalytic core domain; Region: FMT_core; cd08369 358681009004 active site 358681009005 cosubstrate binding site; other site 358681009006 substrate binding site [chemical binding]; other site 358681009007 catalytic site [active] 358681009008 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 358681009009 amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733 358681009010 acyl-activating enzyme (AAE) consensus motif; other site 358681009011 AMP binding site [chemical binding]; other site 358681009012 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 358681009013 Condensation domain; Region: Condensation; pfam00668 358681009014 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 358681009015 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 358681009016 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 358681009017 acyl-activating enzyme (AAE) consensus motif; other site 358681009018 AMP binding site [chemical binding]; other site 358681009019 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 358681009020 Condensation domain; Region: Condensation; pfam00668 358681009021 non-ribosomal peptide synthase domain TIGR01720; Region: NRPS-para261 358681009022 Condensation domain; Region: Condensation; pfam00668 358681009023 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 358681009024 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 358681009025 acyl-activating enzyme (AAE) consensus motif; other site 358681009026 AMP binding site [chemical binding]; other site 358681009027 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 358681009028 peptide synthase; Provisional; Region: PRK12316 358681009029 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 358681009030 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 358681009031 acyl-activating enzyme (AAE) consensus motif; other site 358681009032 AMP binding site [chemical binding]; other site 358681009033 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 358681009034 non-ribosomal peptide synthase domain TIGR01720; Region: NRPS-para261 358681009035 The adenylation domain of nonribosomal peptide synthetases (NRPS), including Saframycin A gene cluster from Streptomyces lavendulae; Region: A_NRPS_Sfm_like; cd12115 358681009036 acyl-activating enzyme (AAE) consensus motif; other site 358681009037 AMP binding site [chemical binding]; other site 358681009038 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 358681009039 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 358681009040 The adenylation domain of nonribosomal peptide synthetases (NRPS), including Bacillus subtilis termination module Surfactin (SrfA-C); Region: A_NRPS_Srf_like; cd12117 358681009041 acyl-activating enzyme (AAE) consensus motif; other site 358681009042 AMP binding site [chemical binding]; other site 358681009043 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 358681009044 non-ribosomal peptide synthase domain TIGR01720; Region: NRPS-para261 358681009045 The adenylation domain of nonribosomal peptide synthetases (NRPS), including Saframycin A gene cluster from Streptomyces lavendulae; Region: A_NRPS_Sfm_like; cd12115 358681009046 acyl-activating enzyme (AAE) consensus motif; other site 358681009047 AMP binding site [chemical binding]; other site 358681009048 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 358681009049 Condensation domain; Region: Condensation; pfam00668 358681009050 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 358681009051 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 358681009052 The adenylation domain of nonribosomal peptide synthetases (NRPS), including Bacillus subtilis termination module Surfactin (SrfA-C); Region: A_NRPS_Srf_like; cd12117 358681009053 acyl-activating enzyme (AAE) consensus motif; other site 358681009054 AMP binding site [chemical binding]; other site 358681009055 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 358681009056 Condensation domain; Region: Condensation; pfam00668 358681009057 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 358681009058 non-ribosomal peptide synthase domain TIGR01720; Region: NRPS-para261 358681009059 Condensation domain; Region: Condensation; pfam00668 358681009060 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 358681009061 The adenylation domain of nonribosomal peptide synthetases (NRPS), including Bacillus subtilis termination module Surfactin (SrfA-C); Region: A_NRPS_Srf_like; cd12117 358681009062 acyl-activating enzyme (AAE) consensus motif; other site 358681009063 AMP binding site [chemical binding]; other site 358681009064 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 358681009065 peptide synthase; Provisional; Region: PRK12316 358681009066 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 358681009067 The adenylation domain of nonribosomal peptide synthetases (NRPS), including Bacillus subtilis termination module Surfactin (SrfA-C); Region: A_NRPS_Srf_like; cd12117 358681009068 acyl-activating enzyme (AAE) consensus motif; other site 358681009069 AMP binding site [chemical binding]; other site 358681009070 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 358681009071 non-ribosomal peptide synthase domain TIGR01720; Region: NRPS-para261 358681009072 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 358681009073 acyl-activating enzyme (AAE) consensus motif; other site 358681009074 AMP binding site [chemical binding]; other site 358681009075 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 358681009076 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 358681009077 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 358681009078 acyl-activating enzyme (AAE) consensus motif; other site 358681009079 AMP binding site [chemical binding]; other site 358681009080 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 358681009081 non-ribosomal peptide synthase domain TIGR01720; Region: NRPS-para261 358681009082 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 358681009083 acyl-activating enzyme (AAE) consensus motif; other site 358681009084 AMP binding site [chemical binding]; other site 358681009085 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 358681009086 Condensation domain; Region: Condensation; pfam00668 358681009087 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961 358681009088 Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and...; Region: SR_ResInv; cd03768 358681009089 catalytic residues [active] 358681009090 catalytic nucleophile [active] 358681009091 Presynaptic Site I dimer interface [polypeptide binding]; other site 358681009092 Synaptic Antiparallel dimer interface [polypeptide binding]; other site 358681009093 Synaptic Flat tetramer interface [polypeptide binding]; other site 358681009094 Synaptic Site I dimer interface [polypeptide binding]; other site 358681009095 DNA binding site [nucleotide binding] 358681009096 Recombinase; Region: Recombinase; pfam07508 358681009097 Recombinase zinc beta ribbon domain; Region: Zn_ribbon_recom; pfam13408 358681009098 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 358681009099 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 358681009100 non-specific DNA binding site [nucleotide binding]; other site 358681009101 salt bridge; other site 358681009102 sequence-specific DNA binding site [nucleotide binding]; other site 358681009103 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 358681009104 salt bridge; other site 358681009105 non-specific DNA binding site [nucleotide binding]; other site 358681009106 sequence-specific DNA binding site [nucleotide binding]; other site 358681009107 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl17200 358681009108 non-specific DNA binding site [nucleotide binding]; other site 358681009109 salt bridge; other site 358681009110 sequence-specific DNA binding site [nucleotide binding]; other site 358681009111 Helix-turn-helix domain; Region: HTH_36; pfam13730 358681009112 Conserved phage C-terminus (Phg_2220_C); Region: Phg_2220_C; pfam09524 358681009113 hypothetical protein; Validated; Region: PRK08116 358681009114 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 358681009115 Walker A motif; other site 358681009116 ATP binding site [chemical binding]; other site 358681009117 Walker B motif; other site 358681009118 replicative DNA helicase; Region: DnaB; TIGR00665 358681009119 DnaB-like helicase N terminal domain; Region: DnaB; pfam00772 358681009120 DnaB helicase C terminal domain. The hexameric helicase DnaB unwinds the DNA duplex at the chromosome replication fork. Although the mechanism by which DnaB both couples ATP hydrolysis to translocation along DNA and denatures the duplex is unknown, a...; Region: DnaB_C; cd00984 358681009121 Walker A motif; other site 358681009122 ATP binding site [chemical binding]; other site 358681009123 Walker B motif; other site 358681009124 DNA binding loops [nucleotide binding] 358681009125 Phage regulatory protein Rha (Phage_pRha); Region: Phage_pRha; cl10713 358681009126 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 358681009127 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 358681009128 active site 358681009129 Restriction endonuclease [Defense mechanisms]; Region: McrA; COG1403 358681009130 Phage terminase-like protein, large subunit [General function prediction only]; Region: COG4626 358681009131 Phage-related protein [Function unknown]; Region: COG4695; cl01923 358681009132 Phage portal protein; Region: Phage_portal; pfam04860 358681009133 Phage head maturation protease [General function prediction only]; Region: COG3740 358681009134 phage major capsid protein, HK97 family; Region: major_cap_HK97; TIGR01554 358681009135 Phage capsid family; Region: Phage_capsid; pfam05065 358681009136 Phage head-tail joining protein; Region: Phage_H_T_join; cl11461 358681009137 Phage head-tail joining protein; Region: Phage_H_T_join; pfam05521 358681009138 Bacteriophage protein of unknown function (DUF646); Region: DUF646; cl12124 358681009139 Phage tail sheath protein; Region: Phage_sheath_1; cl01389 358681009140 Protein of unknown function (DUF2001); Region: DUF2001; pfam09393 358681009141 Phage XkdN-like protein; Region: XkdN; pfam08890 358681009142 tape measure domain; Region: tape_meas_nterm; TIGR02675 358681009143 Protein of unknown function (DUF2577); Region: DUF2577; pfam10844 358681009144 Protein of unknown function (DUF2634); Region: DUF2634; pfam10934 358681009145 Baseplate J-like protein; Region: Baseplate_J; pfam04865 358681009146 Uncharacterized protein conserved in bacteria (DUF2313); Region: DUF2313; cl01542 358681009147 Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726 358681009148 Putative catalytic NodB homology domain of uncharacterized prokaryotic polysaccharide deacetylases which consist of a 6-stranded beta/alpha barrel; Region: CE4_DAC_u1_6s; cd10970 358681009149 putative active site [active] 358681009150 putative metal binding site [ion binding]; other site 358681009151 Haemolysin XhlA; Region: XhlA; pfam10779 358681009152 Muramidase (flagellum-specific) [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FlgJ; COG1705 358681009153 Adenylation domain of proteins similar to ATP-dependent polynucleotide ligases; Region: Adenylation_DNA_ligase_like; cl12015 358681009154 The Oligonucleotide/oligosaccharide binding (OB)-fold domain is a DNA-binding module that is part of the catalytic core unit of ATP dependent DNA ligases; Region: OBF_DNA_ligase_family; cl08424 358681009155 DNA binding site [nucleotide binding] 358681009156 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 358681009157 salt bridge; other site 358681009158 non-specific DNA binding site [nucleotide binding]; other site 358681009159 sequence-specific DNA binding site [nucleotide binding]; other site 358681009160 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 358681009161 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 358681009162 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 358681009163 acyl-activating enzyme (AAE) consensus motif; other site 358681009164 AMP binding site [chemical binding]; other site 358681009165 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 358681009166 Condensation domain; Region: Condensation; pfam00668 358681009167 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 358681009168 non-ribosomal peptide synthase domain TIGR01720; Region: NRPS-para261 358681009169 peptide synthase; Provisional; Region: PRK12467 358681009170 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 358681009171 acyl-activating enzyme (AAE) consensus motif; other site 358681009172 AMP binding site [chemical binding]; other site 358681009173 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 358681009174 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 358681009175 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 358681009176 acyl-activating enzyme (AAE) consensus motif; other site 358681009177 AMP binding site [chemical binding]; other site 358681009178 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 358681009179 non-ribosomal peptide synthase domain TIGR01720; Region: NRPS-para261 358681009180 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 358681009181 acyl-activating enzyme (AAE) consensus motif; other site 358681009182 AMP binding site [chemical binding]; other site 358681009183 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 358681009184 L-aminoadipate-semialdehyde dehydrogenase; Region: alpha_am_amid; TIGR03443 358681009185 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 358681009186 The adenylation domain of nonribosomal peptide synthetases (NRPS), including Saframycin A gene cluster from Streptomyces lavendulae; Region: A_NRPS_Sfm_like; cd12115 358681009187 acyl-activating enzyme (AAE) consensus motif; other site 358681009188 AMP binding site [chemical binding]; other site 358681009189 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 358681009190 extended (e) SDRs, subgroup 1; Region: SDR_e1; cd05235 358681009191 putative NAD(P) binding site [chemical binding]; other site 358681009192 active site 358681009193 putative substrate binding site [chemical binding]; other site 358681009194 Phospholipase_D-nuclease N-terminal; Region: PLDc_N; pfam13396 358681009195 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 358681009196 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 358681009197 Walker A/P-loop; other site 358681009198 ATP binding site [chemical binding]; other site 358681009199 Q-loop/lid; other site 358681009200 ABC transporter signature motif; other site 358681009201 Walker B; other site 358681009202 D-loop; other site 358681009203 H-loop/switch region; other site 358681009204 ABC-2 family transporter protein; Region: ABC2_membrane_2; cl17866 358681009205 Putative heavy-metal-binding; Region: YbjQ_1; cl00426 358681009206 SH3 domain protein; Region: SH3_and_anchor; TIGR04211 358681009207 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 358681009208 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 358681009209 active site 358681009210 phosphorylation site [posttranslational modification] 358681009211 intermolecular recognition site; other site 358681009212 dimerization interface [polypeptide binding]; other site 358681009213 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 358681009214 DNA binding site [nucleotide binding] 358681009215 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 358681009216 dimerization interface [polypeptide binding]; other site 358681009217 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 358681009218 dimer interface [polypeptide binding]; other site 358681009219 phosphorylation site [posttranslational modification] 358681009220 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 358681009221 ATP binding site [chemical binding]; other site 358681009222 Mg2+ binding site [ion binding]; other site 358681009223 G-X-G motif; other site 358681009224 NnaC (CMP-NeuNAc synthetase) _like subfamily of SGNH_hydrolases, a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its...; Region: NnaC_like; cd01841 358681009225 active site 358681009226 catalytic triad [active] 358681009227 oxyanion hole [active] 358681009228 Predicted membrane protein involved in D-alanine export [Cell envelope biogenesis, outer membrane]; Region: DltB; COG1696 358681009229 DHHW protein; Region: DHHW; pfam14286 358681009230 DHHW protein; Region: DHHW; pfam14286 358681009231 Domain of unknown function (DUF4358); Region: DUF4358; pfam14270 358681009232 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3214 358681009233 Protein of unknown function (DUF1006); Region: DUF1006; pfam06224 358681009234 Translation elongation factors (GTPases) [Translation, ribosomal structure and biogenesis]; Region: FusA; COG0480 358681009235 Tet(M)-like family includes Tet(M), Tet(O), Tet(W), and OtrA, containing tetracycline resistant proteins; Region: TetM_like; cd04168 358681009236 G1 box; other site 358681009237 putative GEF interaction site [polypeptide binding]; other site 358681009238 GTP/Mg2+ binding site [chemical binding]; other site 358681009239 Switch I region; other site 358681009240 G2 box; other site 358681009241 G3 box; other site 358681009242 Switch II region; other site 358681009243 G4 box; other site 358681009244 G5 box; other site 358681009245 Translation_Factor_II_like: Elongation factor Tu (EF-Tu) domain II-like proteins. Elongation factor Tu consists of three structural domains, this family represents the second domain. Domain II adopts a beta barrel structure and is involved in binding to...; Region: Translation_Factor_II_like; cl02787 358681009246 Elongation Factor G-like domain IV. This family includes the translational elongation factor termed EF-2 (for Archaea and Eukarya) and EF-G (for Bacteria), ribosomal protection proteins that mediate tetracycline resistance and, an evolutionarily...; Region: EFG_like_IV; cl02789 358681009247 Tet_C: C-terminus of ribosomal protection proteins Tet(M) and Tet(O). This domain has homology to the C terminal domains of the elongation factors EF-G and EF-2. Tet(M) and Tet(O) catalyze the release of tetracycline (Tc) from the ribosome in a...; Region: Tet_C; cd03711 358681009248 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 358681009249 global nitrogen regulator NtcA, cyanobacterial; Region: NtcA_cyano; TIGR03697 358681009250 ligand binding site [chemical binding]; other site 358681009251 flexible hinge region; other site 358681009252 Crp-like helix-turn-helix domain; Region: HTH_Crp_2; pfam13545 358681009253 non-specific DNA interactions [nucleotide binding]; other site 358681009254 DNA binding site [nucleotide binding] 358681009255 sequence specific DNA binding site [nucleotide binding]; other site 358681009256 putative cAMP binding site [chemical binding]; other site 358681009257 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 358681009258 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 358681009259 ligand binding site [chemical binding]; other site 358681009260 flexible hinge region; other site 358681009261 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 358681009262 putative switch regulator; other site 358681009263 non-specific DNA interactions [nucleotide binding]; other site 358681009264 DNA binding site [nucleotide binding] 358681009265 sequence specific DNA binding site [nucleotide binding]; other site 358681009266 putative cAMP binding site [chemical binding]; other site 358681009267 Aromatic ring hydroxylase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2368 358681009268 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 358681009269 4-hydroxyphenylacetate 3-hydroxylase C terminal; Region: HpaB; pfam03241 358681009270 3-hydroxyanthranilate 3,4-dioxygenase; Provisional; Region: PRK13264 358681009271 Amidohydrolase; Region: Amidohydro_2; pfam04909 358681009272 This group of proteins belong to a large family of YjgF/YER057c/UK114-like proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence...; Region: YjgF_YER057c_UK114_like_1; cd02199 358681009273 homotrimer interaction site [polypeptide binding]; other site 358681009274 putative active site [active] 358681009275 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 358681009276 Human aldehyde dehydrogenase family 8 member A1-like; Region: ALDH_F8_HMSADH; cd07093 358681009277 NAD binding site [chemical binding]; other site 358681009278 catalytic residues [active] 358681009279 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; cl11421 358681009280 acetaldehyde dehydrogenase; Validated; Region: PRK08300 358681009281 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 358681009282 Prokaryotic acetaldehyde dehydrogenase, dimerisation; Region: AcetDehyd-dimer; pfam09290 358681009283 4-hyroxy-2-oxovalerate/4-hydroxy-2-oxopentanoic acid aldolase,; Validated; Region: PRK08195 358681009284 4-hydroxy-2-oxovalerate aldolase, N-terminal catalytic TIM barrel domain; Region: DRE_TIM_HOA; cd07943 358681009285 active site 358681009286 catalytic residues [active] 358681009287 metal binding site [ion binding]; metal-binding site 358681009288 DmpG-like communication domain; Region: DmpG_comm; pfam07836 358681009289 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; cl11421 358681009290 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 358681009291 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 358681009292 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 358681009293 hypothetical protein; Provisional; Region: PRK13660 358681009294 Glutamate synthase (GltS) FMN-binding domain. GltS is a complex iron-sulfur flavoprotein that catalyzes the reductive synthesis of L-glutamate from 2-oxoglutarate and L-glutamine via intramolecular channelling of ammonia, a reaction in the plant, yeast...; Region: GltS_FMN; cd02808 358681009295 active site 358681009296 FMN binding site [chemical binding]; other site 358681009297 substrate binding site [chemical binding]; other site 358681009298 3Fe-4S cluster binding site [ion binding]; other site 358681009299 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 358681009300 GAF domain; Region: GAF; pfam01590 358681009301 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 358681009302 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 358681009303 DNA binding residues [nucleotide binding] 358681009304 dimerization interface [polypeptide binding]; other site 358681009305 Predicted metal-dependent hydrolase with the TIM-barrel fold [General function prediction only]; Region: COG1574 358681009306 YtcJ_like metal dependent amidohydrolases. YtcJ is a Bacillus subtilis ORF of unknown function. The Arabidopsis homolog LAF3 has been identified as a factor required for photochrome A signalling; Region: YtcJ_like; cd01300 358681009307 active site 358681009308 Putative intracellular protease/amidase [General function prediction only]; Region: ThiJ; COG0693 358681009309 Type 1 glutamine amidotransferase (GATase1)-like domain found in a subgroup of proteins similar to PfpI from Pyrococcus furiosus; Region: GATase1_PfpI_2; cd03139 358681009310 conserved cys residue [active] 358681009311 Toxic anion resistance protein (TelA); Region: TelA; pfam05816 358681009312 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198 358681009313 metal ion-dependent adhesion site (MIDAS); other site 358681009314 DJ-1 family protein; Region: not_thiJ; TIGR01383 358681009315 Type 1 glutamine amidotransferase (GATase1)-like domain found in a subgroup of proteins similar to PfpI from Pyrococcus furiosus; Region: GATase1_PfpI_2; cd03139 358681009316 conserved cys residue [active] 358681009317 ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614 358681009318 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 358681009319 intersubunit interface [polypeptide binding]; other site 358681009320 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 358681009321 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 358681009322 ABC-ATPase subunit interface; other site 358681009323 dimer interface [polypeptide binding]; other site 358681009324 putative PBP binding regions; other site 358681009325 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 358681009326 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 358681009327 Walker A/P-loop; other site 358681009328 ATP binding site [chemical binding]; other site 358681009329 Q-loop/lid; other site 358681009330 ABC transporter signature motif; other site 358681009331 Walker B; other site 358681009332 D-loop; other site 358681009333 H-loop/switch region; other site 358681009334 Histidine kinase; Region: HisKA_3; pfam07730 358681009335 Histidine kinase-like ATPase domain; Region: HATPase_c_2; pfam13581 358681009336 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 358681009337 ATP binding site [chemical binding]; other site 358681009338 Mg2+ binding site [ion binding]; other site 358681009339 G-X-G motif; other site 358681009340 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 358681009341 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 358681009342 active site 358681009343 phosphorylation site [posttranslational modification] 358681009344 intermolecular recognition site; other site 358681009345 dimerization interface [polypeptide binding]; other site 358681009346 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 358681009347 DNA binding residues [nucleotide binding] 358681009348 dimerization interface [polypeptide binding]; other site 358681009349 Short-chain alcohol dehydrogenase of unknown specificity [General function prediction only]; Region: COG4221 358681009350 classical (c) SDRs; Region: SDR_c; cd05233 358681009351 NAD(P) binding site [chemical binding]; other site 358681009352 active site 358681009353 This family contains NADPH-dependent flavin reductase and oxygen-insensitive nitroreductase. These enzymes are homodimeric flavoproteins that contain one FMN per monomer as a cofactor. Flavin reductase catalyzes the reduction of flavin by using NADPH as...; Region: NfsA_FRP; cd02146 358681009354 dimer interface [polypeptide binding]; other site 358681009355 FMN binding site [chemical binding]; other site 358681009356 NADPH bind site [chemical binding]; other site 358681009357 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 358681009358 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 358681009359 dihydrolipoamide dehydrogenase; Reviewed; Region: PRK06416 358681009360 Anaerobic glycerol-3-phosphate dehydrogenase [Amino acid transport and metabolism]; Region: GlpB; cl17730 358681009361 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 358681009362 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 358681009363 Multidrug resistance efflux pump [Defense mechanisms]; Region: EmrA; COG1566 358681009364 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 358681009365 HlyD family secretion protein; Region: HlyD_3; pfam13437 358681009366 ABC-2 family transporter protein; Region: ABC2_membrane_3; pfam12698 358681009367 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 358681009368 ABC-2 type transporter; Region: ABC2_membrane; cl17235 358681009369 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl17221 358681009370 Protein of unknown function; Region: DUF3658; pfam12395 358681009371 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 358681009372 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 358681009373 active site 358681009374 phosphorylation site [posttranslational modification] 358681009375 intermolecular recognition site; other site 358681009376 dimerization interface [polypeptide binding]; other site 358681009377 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 358681009378 DNA binding site [nucleotide binding] 358681009379 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 358681009380 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 358681009381 dimer interface [polypeptide binding]; other site 358681009382 phosphorylation site [posttranslational modification] 358681009383 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 358681009384 ATP binding site [chemical binding]; other site 358681009385 Mg2+ binding site [ion binding]; other site 358681009386 G-X-G motif; other site 358681009387 Repeat of Unknown Function (DUF347); Region: DUF347; pfam03988 358681009388 Repeat of Unknown Function (DUF347); Region: DUF347; pfam03988 358681009389 Repeat of Unknown Function (DUF347); Region: DUF347; pfam03988 358681009390 Repeat of Unknown Function (DUF347); Region: DUF347; pfam03988 358681009391 Repeat of Unknown Function (DUF347); Region: DUF347; pfam03988 358681009392 Repeat of Unknown Function (DUF347); Region: DUF347; pfam03988 358681009393 Repeat of Unknown Function (DUF347); Region: DUF347; pfam03988 358681009394 Repeat of Unknown Function (DUF347); Region: DUF347; pfam03988 358681009395 Transcriptional regulators [Transcription]; Region: FadR; COG2186 358681009396 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 358681009397 DNA-binding site [nucleotide binding]; DNA binding site 358681009398 FCD domain; Region: FCD; pfam07729 358681009399 cystathionine gamma-synthase; Provisional; Region: PRK08249 358681009400 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 358681009401 homodimer interface [polypeptide binding]; other site 358681009402 substrate-cofactor binding pocket; other site 358681009403 pyridoxal 5'-phosphate binding site [chemical binding]; other site 358681009404 catalytic residue [active] 358681009405 homoserine dehydrogenase; Provisional; Region: PRK06270 358681009406 NAD(P) binding domain of amino acid dehydrogenase-like proteins; Region: NAD_bind_amino_acid_DH; cl17226 358681009407 NAD(P) binding pocket [chemical binding]; other site 358681009408 Homoserine dehydrogenase; Region: Homoserine_dh; pfam00742 358681009409 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 358681009410 Uncharacterized ALDH (y4uC) with similarity to Tortula ruralis aldehyde dehydrogenase ALDH21A1; Region: ALDH_y4uC; cd07149 358681009411 NAD(P) binding site [chemical binding]; other site 358681009412 catalytic residues [active] 358681009413 S-methylmethionine transporter; Provisional; Region: PRK11387 358681009414 homocysteine methyltransferase; Provisional; Region: mmuM; PRK09485 358681009415 Homocysteine S-methyltransferase; Region: S-methyl_trans; pfam02574 358681009416 Protein of unknown function (DUF4241); Region: DUF4241; pfam14025 358681009417 purine nucleoside phosphorylase; Reviewed; Region: deoD; PRK05819 358681009418 Uridine phosphorylase [Nucleotide transport and metabolism]; Region: Udp; COG2820 358681009419 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 358681009420 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 358681009421 active site 358681009422 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 358681009423 active site 358681009424 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872 358681009425 D-alanyl-D-alanine carboxypeptidase; Region: Peptidase_S11; pfam00768 358681009426 Penicillin-binding protein 5, C-terminal domain; Region: PBP5_C; smart00936 358681009427 Guanosine polyphosphate pyrophosphohydrolases/synthetases [Signal transduction mechanisms / Transcription]; Region: SpoT; COG0317 358681009428 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 358681009429 synthetase active site [active] 358681009430 NTP binding site [chemical binding]; other site 358681009431 metal binding site [ion binding]; metal-binding site 358681009432 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 358681009433 Peptidase family M23; Region: Peptidase_M23; pfam01551 358681009434 Small, acid-soluble spore proteins, alpha/beta type; Region: SASP; pfam00269 358681009435 5'-3' exonuclease; Region: 53EXOc; smart00475 358681009436 PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859 358681009437 active site 358681009438 metal binding site 1 [ion binding]; metal-binding site 358681009439 putative 5' ssDNA interaction site; other site 358681009440 metal binding site 3; metal-binding site 358681009441 metal binding site 2 [ion binding]; metal-binding site 358681009442 H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898 358681009443 putative DNA binding site [nucleotide binding]; other site 358681009444 putative metal binding site [ion binding]; other site 358681009445 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 358681009446 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 358681009447 putative DNA binding site [nucleotide binding]; other site 358681009448 putative Zn2+ binding site [ion binding]; other site 358681009449 Uncharacterized protein containing a von Willebrand factor type A (vWA) domain [General function prediction only]; Region: COG2425 358681009450 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057 358681009451 metal ion-dependent adhesion site (MIDAS); other site 358681009452 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 358681009453 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 358681009454 Walker A motif; other site 358681009455 ATP binding site [chemical binding]; other site 358681009456 Walker B motif; other site 358681009457 arginine finger; other site 358681009458 TRAP-type C4-dicarboxylate transport system, large permease component [Carbohydrate transport and metabolism]; Region: DctQ; cl17274 358681009459 Uncharacterized membrane protein [Function unknown]; Region: COG3949 358681009460 SUKH-3 immunity protein; Region: SUKH-3; pfam14433 358681009461 Domain of unknown function (DUF4261); Region: DUF4261; pfam14080 358681009462 hypothetical protein; Provisional; Region: PRK02268 358681009463 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 358681009464 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 358681009465 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 358681009466 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 358681009467 Major Facilitator Superfamily; Region: MFS_1; pfam07690 358681009468 putative substrate translocation pore; other site 358681009469 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 358681009470 L-lactate permease; Region: Lactate_perm; cl00701 358681009471 L-lactate permease [Energy production and conversion]; Region: LldP; COG1620 358681009472 Transcriptional regulators [Transcription]; Region: FadR; COG2186 358681009473 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 358681009474 DNA-binding site [nucleotide binding]; DNA binding site 358681009475 FCD domain; Region: FCD; pfam07729 358681009476 CoB--CoM heterodisulfide reductase, subunit B; Region: CoB_CoM_SS_B; TIGR03288 358681009477 Cysteine-rich domain; Region: CCG; pfam02754 358681009478 Cysteine-rich domain; Region: CCG; pfam02754 358681009479 Uncharacterized conserved protein containing a ferredoxin-like domain [Energy production and conversion]; Region: COG1139 358681009480 Uncharacterized ACR, YkgG family COG1556; Region: DUF162; pfam02589 358681009481 4Fe-4S binding domain; Region: Fer4; cl02805 358681009482 Domain of unknown function (DUF3390); Region: DUF3390; pfam11870 358681009483 Uncharacterized ACR, YkgG family COG1556; Region: DUF162; cl00674 358681009484 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK05565 358681009485 classical (c) SDRs; Region: SDR_c; cd05233 358681009486 NAD(P) binding site [chemical binding]; other site 358681009487 active site 358681009488 Transcriptional regulator [Transcription]; Region: LysR; COG0583 358681009489 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 358681009490 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 358681009491 dimerization interface [polypeptide binding]; other site 358681009492 short chain dehydrogenase; Provisional; Region: PRK06500 358681009493 classical (c) SDRs; Region: SDR_c; cd05233 358681009494 NAD(P) binding site [chemical binding]; other site 358681009495 active site 358681009496 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 358681009497 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 358681009498 DNA binding residues [nucleotide binding] 358681009499 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 358681009500 putative DNA binding site [nucleotide binding]; other site 358681009501 Predicted transcriptional regulator [Transcription]; Region: COG2345 358681009502 putative Zn2+ binding site [ion binding]; other site 358681009503 Superoxide dismutase [Inorganic ion transport and metabolism]; Region: SodA; COG0605 358681009504 Iron/manganese superoxide dismutases, alpha-hairpin domain; Region: Sod_Fe_N; pfam00081 358681009505 Iron/manganese superoxide dismutases, C-terminal domain; Region: Sod_Fe_C; pfam02777 358681009506 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 358681009507 Small, acid-soluble spore proteins, alpha/beta type; Region: SASP; pfam00269 358681009508 Uncharacterized conserved protein, YhbC family [Function unknown]; Region: COG0782 358681009509 Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272 358681009510 BlaR1 peptidase M56; Region: Peptidase_M56; pfam05569 358681009511 Domain of unknown function (DUF4367); Region: DUF4367; pfam14285 358681009512 copper transport repressor, CopY/TcrY family; Region: CopY_TcrY; TIGR02698 358681009513 Penicillinase repressor; Region: Pencillinase_R; pfam03965 358681009514 Alpha-tubulin suppressor and related RCC1 domain-containing proteins [Cell division and chromosome partitioning / Cytoskeleton]; Region: ATS1; COG5184 358681009515 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415 358681009516 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1_2; pfam13540 358681009517 Catalase [Inorganic ion transport and metabolism]; Region: KatE; COG0753 358681009518 Clade 1 of the heme-binding enzyme catalase; Region: catalase_clade_1; cd08154 358681009519 tetramer interface [polypeptide binding]; other site 358681009520 heme binding pocket [chemical binding]; other site 358681009521 2-phosphosulpholactate phosphatase; Region: 2-ph_phosp; cl00895 358681009522 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 358681009523 DNA-binding site [nucleotide binding]; DNA binding site 358681009524 RNA-binding motif; other site 358681009525 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 358681009526 active site residue [active] 358681009527 Uncharacterized protein with SCP/PR1 domains [Function unknown]; Region: COG2340 358681009528 SCP_bacterial: SCP-like extracellular protein domain, as found in bacteria and archaea. The wider family of SCP containing proteins includes plant pathogenesis-related protein 1 (PR-1), CRISPs, mammalian cysteine-rich secretory proteins, and allergen 5...; Region: SCP_bacterial; cd05379 358681009529 homoserine dehydrogenase; Provisional; Region: PRK06270 358681009530 Homoserine dehydrogenase, NAD binding domain; Region: NAD_binding_3; pfam03447 358681009531 Homoserine dehydrogenase; Region: Homoserine_dh; pfam00742 358681009532 Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487 358681009533 active site 358681009534 catalytic residues [active] 358681009535 metal binding site [ion binding]; metal-binding site 358681009536 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 358681009537 Aminotransferase class I and II; Region: Aminotran_1_2; pfam00155 358681009538 pyridoxal 5'-phosphate binding site [chemical binding]; other site 358681009539 homodimer interface [polypeptide binding]; other site 358681009540 catalytic residue [active] 358681009541 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 358681009542 EamA-like transporter family; Region: EamA; pfam00892 358681009543 Predicted O-acyltransferase [General function prediction only]; Region: COG3274 358681009544 Acyltransferase family; Region: Acyl_transf_3; pfam01757 358681009545 Uncharacterized conserved protein (COG2071); Region: DUF2071; pfam09844 358681009546 Glutamate synthase (GltS) FMN-binding domain. GltS is a complex iron-sulfur flavoprotein that catalyzes the reductive synthesis of L-glutamate from 2-oxoglutarate and L-glutamine via intramolecular channelling of ammonia, a reaction in the plant, yeast...; Region: GltS_FMN; cd02808 358681009547 active site 358681009548 FMN binding site [chemical binding]; other site 358681009549 substrate binding site [chemical binding]; other site 358681009550 3Fe-4S cluster binding site [ion binding]; other site 358681009551 Predicted membrane protein [Function unknown]; Region: COG2311 358681009552 Protein of unknown function (DUF418); Region: DUF418; cl12135 358681009553 Protein of unknown function (DUF418); Region: DUF418; pfam04235 358681009554 Branched-chain amino acid transport protein; Region: Branch_AA_trans; pfam05525 358681009555 YheC/D like ATP-grasp; Region: ATPgrasp_YheCD; pfam14398 358681009556 Aspartate alpha-decarboxylase or L-aspartate 1-decarboxylase, a pyruvoyl group-dependent decarboxylase in beta-alanine production; Region: Asp_decarbox; cd06919 358681009557 tetramerization interface [polypeptide binding]; other site 358681009558 active site 358681009559 Malate/L-lactate dehydrogenases [Energy production and conversion]; Region: COG2055 358681009560 D-Ala-D-Ala carboxypeptidase 3 (S13) family; Region: Peptidase_S13; pfam02113 358681009561 D-alanyl-D-alanine carboxypeptidase, serine-type, PBP4 family; Region: PBP4; TIGR00666 358681009562 D-Ala-D-Ala carboxypeptidase 3 (S13) family; Region: Peptidase_S13; cl17429 358681009563 D-alanyl-D-alanine carboxypeptidase, serine-type, PBP4 family; Region: PBP4; TIGR00666 358681009564 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4200 358681009565 ABC-2 family transporter protein; Region: ABC2_membrane_4; pfam12730 358681009566 ABC-2 family transporter protein; Region: ABC2_membrane_4; pfam12730 358681009567 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4200 358681009568 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 358681009569 ATP-binding cassette domain of the bacitracin-resistance transporter; Region: ABC_BcrA_bacitracin_resist; cd03268 358681009570 Walker A/P-loop; other site 358681009571 ATP binding site [chemical binding]; other site 358681009572 Q-loop/lid; other site 358681009573 ABC transporter signature motif; other site 358681009574 Walker B; other site 358681009575 D-loop; other site 358681009576 H-loop/switch region; other site 358681009577 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 358681009578 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 358681009579 active site 358681009580 phosphorylation site [posttranslational modification] 358681009581 intermolecular recognition site; other site 358681009582 dimerization interface [polypeptide binding]; other site 358681009583 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 358681009584 DNA binding site [nucleotide binding] 358681009585 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 358681009586 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 358681009587 dimer interface [polypeptide binding]; other site 358681009588 phosphorylation site [posttranslational modification] 358681009589 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 358681009590 ATP binding site [chemical binding]; other site 358681009591 Mg2+ binding site [ion binding]; other site 358681009592 G-X-G motif; other site 358681009593 NMT1/THI5 like; Region: NMT1; pfam09084 358681009594 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 358681009595 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 358681009596 dimer interface [polypeptide binding]; other site 358681009597 conserved gate region; other site 358681009598 putative PBP binding loops; other site 358681009599 ABC-ATPase subunit interface; other site 358681009600 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 358681009601 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 358681009602 Walker A/P-loop; other site 358681009603 ATP binding site [chemical binding]; other site 358681009604 Q-loop/lid; other site 358681009605 ABC transporter signature motif; other site 358681009606 Walker B; other site 358681009607 D-loop; other site 358681009608 H-loop/switch region; other site 358681009609 Putative transcription activator [Transcription]; Region: TenA; COG0819 358681009610 acetylornithine deacetylase; Validated; Region: PRK08596 358681009611 Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876 358681009612 metal binding site [ion binding]; metal-binding site 358681009613 Thiazole synthase (ThiG) is the tetrameric enzyme that is involved in the formation of the thiazole moiety of thiamin pyrophosphate, an essential ubiquitous cofactor that plays an important role in carbohydrate and amino acid metabolism. ThiG catalyzes...; Region: ThiG; cd04728 358681009614 ThiS interaction site; other site 358681009615 putative active site [active] 358681009616 tetramer interface [polypeptide binding]; other site 358681009617 ThiaminS ubiquitin-like sulfur carrier protein; Region: ThiS; cd00565 358681009618 thiS-thiF/thiG interaction site; other site 358681009619 Kinase associated protein B; Region: KapB; pfam08810 358681009620 Predicted metal-dependent hydrolases related to alanyl-tRNA synthetase HxxxH domain [General function prediction only]; Region: COG2872 358681009621 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863 358681009622 Predicted glycosyl hydrolase [General function prediction only]; Region: COG3858 358681009623 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 358681009624 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 358681009625 Cortical fragment-lytic enzyme (CFLE) is a peptidoglycan hydrolase involved in bacterial endospore germination. CFLE is expressed as an inactive preprotein (called SleB) in the forespore compartment of sporulating cells. SleB translocates across the...; Region: GH18_CFLE_spore_hydrolase; cd02874 358681009626 active site 358681009627 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 358681009628 catalytic residues [active] 358681009629 Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280 358681009630 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 358681009631 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084 358681009632 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 358681009633 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 358681009634 NAD(P) binding site [chemical binding]; other site 358681009635 catalytic residues [active] 358681009636 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 358681009637 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 358681009638 PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556 358681009639 Putative esterase; Region: Esterase; pfam00756 358681009640 S-formylglutathione hydrolase; Region: PLN02442 358681009641 Helix-Turn-Helix DNA binding domain of the transcription regulators TipAL, Mta, and SkgA; Region: HTH_TipAL-Mta; cd01106 358681009642 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 358681009643 DNA binding residues [nucleotide binding] 358681009644 dimer interface [polypeptide binding]; other site 358681009645 TipAS antibiotic-recognition domain; Region: TipAS; pfam07739 358681009646 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 358681009647 Beta-lactamase; Region: Beta-lactamase; pfam00144 358681009648 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 358681009649 Helix-Turn-Helix DNA binding domain of the BmrR transcription regulator; Region: HTH_BmrR; cd01107 358681009650 DNA binding residues [nucleotide binding] 358681009651 drug binding residues [chemical binding]; other site 358681009652 dimer interface [polypeptide binding]; other site 358681009653 Bacterial transcription activator, effector binding domain; Region: AraC_E_bind; smart00871 358681009654 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 358681009655 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 358681009656 Coenzyme A binding pocket [chemical binding]; other site 358681009657 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 358681009658 S-adenosylmethionine binding site [chemical binding]; other site 358681009659 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 358681009660 Major Facilitator Superfamily; Region: MFS_1; pfam07690 358681009661 putative substrate translocation pore; other site 358681009662 Predicted transcriptional regulators [Transcription]; Region: COG1733 358681009663 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 358681009664 Flavodoxin-like fold; Region: Flavodoxin_2; pfam02525 358681009665 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 358681009666 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 358681009667 Coenzyme A binding pocket [chemical binding]; other site 358681009668 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK07656 358681009669 Prokaryotic long-chain fatty acid CoA synthetases similar to Escherichia coli FadD; Region: FC-FACS_FadD_like; cd05936 358681009670 acyl-activating enzyme (AAE) consensus motif; other site 358681009671 putative AMP binding site [chemical binding]; other site 358681009672 putative active site [active] 358681009673 putative CoA binding site [chemical binding]; other site 358681009674 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 358681009675 D-galactonate transporter; Region: 2A0114; TIGR00893 358681009676 putative substrate translocation pore; other site 358681009677 CapA and related proteins, metallophosphatase domain; Region: MPP_CapA; cd07381 358681009678 Bacterial capsule synthesis protein PGA_cap; Region: PGA_cap; smart00854 358681009679 putative active site [active] 358681009680 putative metal binding site [ion binding]; other site 358681009681 CapA and related proteins, metallophosphatase domain; Region: MPP_CapA; cd07381 358681009682 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 358681009683 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 358681009684 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 358681009685 putative active site [active] 358681009686 Protein of unknown function (DUF418); Region: DUF418; pfam04235 358681009687 Brown fat-inducible thioesterase (BFIT). Brain acyl-CoA hydrolase (BACH). These enzymes deacylate long-chain fatty acids by hydrolyzing acyl-CoA thioesters to free fatty acids and CoA-SH. Eukaryotic members of this family are expressed in brain, testis; Region: BFIT_BACH; cd03442 358681009688 5-methyltetrahydropteroyltriglutamate--homocysteine S-methyltransferase; Provisional; Region: PRK05222 358681009689 CIMS - Cobalamine-independent methonine synthase, or MetE, N-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_N_terminal_like; cd03312 358681009690 THF binding site; other site 358681009691 CIMS - Cobalamine-independent methonine synthase, or MetE, C-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_C_terminal_like; cd03311 358681009692 substrate binding site [chemical binding]; other site 358681009693 THF binding site; other site 358681009694 zinc-binding site [ion binding]; other site 358681009695 ribonucleotide-diphosphate reductase subunit beta; Provisional; Region: nrdF2; PRK13966 358681009696 Ribonucleotide Reductase, R2/beta subunit, ferritin-like diiron-binding domain; Region: RNRR2; cd01049 358681009697 dimer interface [polypeptide binding]; other site 358681009698 putative radical transfer pathway; other site 358681009699 diiron center [ion binding]; other site 358681009700 tyrosyl radical; other site 358681009701 ribonucleotide-diphosphate reductase subunit alpha; Validated; Region: PRK07632 358681009702 Ribonucleotide reductase N-terminal; Region: RNR_N; pfam08343 358681009703 Class I ribonucleotide reductase; Region: RNR_I; cd01679 358681009704 active site 358681009705 dimer interface [polypeptide binding]; other site 358681009706 catalytic residues [active] 358681009707 effector binding site; other site 358681009708 R2 peptide binding site; other site 358681009709 ribonucleotide reductase stimulatory protein; Reviewed; Region: nrdI; PRK03600 358681009710 Predicted hydrolase of the alpha/beta superfamily [General function prediction only]; Region: COG2819 358681009711 ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141 358681009712 Predicted tRNA(5-methylaminomethyl-2-thiouridylate) methyltransferase, contains the PP-loop ATPase domain [Translation, ribosomal structure and biogenesis]; Region: TrmU; COG0482 358681009713 tRNA methyl transferase. This family represents tRNA(5-methylaminomethyl-2-thiouridine)-methyltransferase which is involved in the biosynthesis of the modified nucleoside 5-methylaminomethyl-2-thiouridine present in the wobble position of some tRNAs; Region: tRNA_Me_trans; cd01998 358681009714 small acid-soluble spore protein Tlp; Provisional; Region: PRK03830 358681009715 Protein of unknown function (DUF952); Region: DUF952; pfam06108 358681009716 Glycerophosphodiester phosphodiesterase domain of uncharacterized bacterial homologs of mammalian glycerophosphodiester phosphodiesterase GDE4; Region: GDPD_GDE4_like_1; cd08613 358681009717 Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584 358681009718 putative active site [active] 358681009719 catalytic site [active] 358681009720 putative metal binding site [ion binding]; other site 358681009721 L-Aminopeptidase D-amidase/D-esterase (DmpA) family; DmpA catalyzes the release of N-terminal D and L amino acids from peptide susbtrates. DmpA is synthesized as a single polypeptide precursor, which is autocatalytically cleaved to the active...; Region: DmpA; cd02253 358681009722 homodimer interface [polypeptide binding]; other site 358681009723 homotetramer interface [polypeptide binding]; other site 358681009724 active site pocket [active] 358681009725 cleavage site 358681009726 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 358681009727 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 358681009728 Coenzyme A binding pocket [chemical binding]; other site 358681009729 PIN (PilT N terminus) domain: Superfamily; Region: PIN_SF; cl14812 358681009730 Predicted Na+-dependent transporter [General function prediction only]; Region: COG0385 358681009731 Sodium Bile acid symporter family; Region: SBF; cl17470 358681009732 Sporulation lipoprotein YhcN/YlaJ (Spore_YhcN_YlaJ); Region: Spore_YhcN_YlaJ; pfam09580 358681009733 Predicted O-methyltransferase [General function prediction only]; Region: COG4122 358681009734 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 358681009735 S-adenosylmethionine binding site [chemical binding]; other site 358681009736 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 358681009737 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 358681009738 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 358681009739 Flagellin N-methylase; Region: FliB; pfam03692 358681009740 Domain of unknown function (DUF4386); Region: DUF4386; pfam14329 358681009741 Pyrabactin resistance 1 (PYR1), PYR1-like (PYL), regulatory component of abscisic acid receptors (RCARs), and related proteins; Region: PYR_PYL_RCAR_like; cd07821 358681009742 putative hydrophobic ligand binding site [chemical binding]; other site 358681009743 protein interface [polypeptide binding]; other site 358681009744 gate; other site 358681009745 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 358681009746 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 358681009747 active site 358681009748 catalytic tetrad [active] 358681009749 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367 358681009750 dimerization domain swap beta strand [polypeptide binding]; other site 358681009751 regulatory protein interface [polypeptide binding]; other site 358681009752 active site 358681009753 regulatory phosphorylation site [posttranslational modification]; other site 358681009754 Protein of unknown function (DUF1341); Region: DUF1341; cl06211 358681009755 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 358681009756 catalytic residue [active] 358681009757 Domain of unknown function (DUF4310); Region: DUF4310; pfam14187 358681009758 Domain of unknown function (DUF4311); Region: DUF4311; pfam14188 358681009759 Domain of unknown function (DUF4312); Region: DUF4312; pfam14189 358681009760 Glycine-rich SFCGS; Region: Gly_rich_SFCGS; pfam14272 358681009761 PRD domain protein EF_0829/AHA_3910; Region: EF_0829; TIGR03582 358681009762 dihydroorotase; Provisional; Region: PRK09237 358681009763 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 358681009764 active site 358681009765 Transcriptional antiterminator [Transcription]; Region: BglG; COG3711 358681009766 PRD domain; Region: PRD; pfam00874 358681009767 PTS_IIB_bgl_like: the PTS (phosphotransferase system) IIB domain of a family of sensory systems composed of a membrane-bound sugar-sensor (similar to BglF) and a transcription antiterminator (similar to BglG) which regulate expression of genes involved...; Region: PTS_IIB_bgl_like; cd05568 358681009768 active site 358681009769 P-loop; other site 358681009770 phosphorylation site [posttranslational modification] 358681009771 3-polyprenyl-4-hydroxybenzoate decarboxylase and related decarboxylases [Coenzyme metabolism]; Region: UbiD; COG0043 358681009772 dUMP phosphatase; Provisional; Region: PRK09449 358681009773 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 358681009774 motif II; other site 358681009775 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cl00220 358681009776 Isochorismatase family; Region: Isochorismatase; pfam00857 358681009777 catalytic triad [active] 358681009778 conserved cis-peptide bond; other site 358681009779 Predicted transcriptional regulators [Transcription]; Region: COG1733 358681009780 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 358681009781 DoxX-like family; Region: DoxX_2; pfam13564 358681009782 CDGSH-type zinc finger. Function unknown; Region: ZnF_CDGSH; smart00704 358681009783 2-enoyl thioester reductase-like; Region: ETR_like; cd05282 358681009784 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 358681009785 NADP binding site [chemical binding]; other site 358681009786 dimer interface [polypeptide binding]; other site 358681009787 Uncharacterized conserved protein [Function unknown]; Region: COG3339 358681009788 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 358681009789 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 358681009790 active site 358681009791 catalytic tetrad [active] 358681009792 acetyl-CoA carboxylase carboxyltransferase alpha subunit; Provisional; Region: accA; CHL00198 358681009793 acetyl-CoA carboxylase carboxyltransferase subunit alpha; Validated; Region: PRK05724 358681009794 Winged helix DNA-binding domain; Region: HTH_27; pfam13463 358681009795 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 358681009796 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270 358681009797 Phosphotransferase enzyme family; Region: APH; pfam01636 358681009798 active site 358681009799 substrate binding site [chemical binding]; other site 358681009800 ATP binding site [chemical binding]; other site 358681009801 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 358681009802 Beta-lactamase; Region: Beta-lactamase; pfam00144 358681009803 ABC-type siderophore export system, fused ATPase and permease components [Secondary metabolites biosynthesis, transport, and catabolism / Inorganic ion transport and metabolism]; Region: PvdE; COG4615 358681009804 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 358681009805 Walker A/P-loop; other site 358681009806 ATP binding site [chemical binding]; other site 358681009807 ABC transporter signature motif; other site 358681009808 Walker B; other site 358681009809 D-loop; other site 358681009810 H-loop/switch region; other site 358681009811 ParB-like nuclease domain; Region: ParB; smart00470 358681009812 2,3-diaminopropionate biosynthesis protein SbnB; Region: dehyd_SbnB_fam; TIGR03944 358681009813 ornithine cyclodeaminase; Validated; Region: PRK06823; cl17400 358681009814 2,3-diaminopropionate biosynthesis protein SbnA; Region: PLP_SbnA_fam; TIGR03945 358681009815 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 358681009816 dimer interface [polypeptide binding]; other site 358681009817 pyridoxal 5'-phosphate binding site [chemical binding]; other site 358681009818 catalytic residue [active] 358681009819 acyl carrier protein; Provisional; Region: PRK07081 358681009820 A predicted NlpC/p60-like peptidase; Region: BtrH; pfam14399 358681009821 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 358681009822 Beta-ketoacyl synthase; Region: PKS_KS; smart00825 358681009823 active site 358681009824 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 358681009825 A predicted NlpC/p60-like peptidase; Region: BtrH; pfam14399 358681009826 Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the "double-glycine" leader peptides from the precursors of various bacteriocins (mostly non-lantibiotic); Region: Peptidase_C39_like; cl00296 358681009827 putative active site [active] 358681009828 (acyl-carrier-protein) S-malonyltransferase [Lipid metabolism]; Region: FabD; COG0331 358681009829 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 358681009830 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 358681009831 Beta-ketoacyl synthase; Region: PKS_KS; smart00825 358681009832 active site 358681009833 Methyltransferase domain; Region: Methyltransf_12; pfam08242 358681009834 ketoreductase (KR), subgroup 2, complex (x) SDRs; Region: KR_2_SDR_x; cd08953 358681009835 KR domain; Region: KR; pfam08659 358681009836 putative NADP binding site [chemical binding]; other site 358681009837 active site 358681009838 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 358681009839 Condensation domain; Region: Condensation; pfam00668 358681009840 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 358681009841 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 358681009842 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 358681009843 acyl-activating enzyme (AAE) consensus motif; other site 358681009844 AMP binding site [chemical binding]; other site 358681009845 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 358681009846 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 358681009847 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 358681009848 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 358681009849 acyl-activating enzyme (AAE) consensus motif; other site 358681009850 AMP binding site [chemical binding]; other site 358681009851 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 358681009852 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 358681009853 amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733 358681009854 acyl-activating enzyme (AAE) consensus motif; other site 358681009855 AMP binding site [chemical binding]; other site 358681009856 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 358681009857 Condensation domain; Region: Condensation; pfam00668 358681009858 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 358681009859 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 358681009860 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 358681009861 amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733 358681009862 acyl-activating enzyme (AAE) consensus motif; other site 358681009863 AMP binding site [chemical binding]; other site 358681009864 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 358681009865 Condensation domain; Region: Condensation; pfam00668 358681009866 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 358681009867 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 358681009868 aspartate aminotransferase; Provisional; Region: PRK05764 358681009869 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 358681009870 pyridoxal 5'-phosphate binding site [chemical binding]; other site 358681009871 homodimer interface [polypeptide binding]; other site 358681009872 catalytic residue [active] 358681009873 Condensation domain; Region: Condensation; pfam00668 358681009874 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 358681009875 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 358681009876 acyl-activating enzyme (AAE) consensus motif; other site 358681009877 AMP binding site [chemical binding]; other site 358681009878 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 358681009879 Condensation domain; Region: Condensation; pfam00668 358681009880 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 358681009881 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 358681009882 Methylmalonyl-CoA epimerase (MMCE); Region: MMCE; cd07249 358681009883 dimer interface [polypeptide binding]; other site 358681009884 substrate binding site [chemical binding]; other site 358681009885 metal binding site [ion binding]; metal-binding site 358681009886 Condensation domain; Region: Condensation; pfam00668 358681009887 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 358681009888 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cl15377 358681009889 Condensation domain; Region: Condensation; pfam00668 358681009890 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 358681009891 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 358681009892 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 358681009893 acyl-activating enzyme (AAE) consensus motif; other site 358681009894 AMP binding site [chemical binding]; other site 358681009895 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 358681009896 Condensation domain; Region: Condensation; pfam00668 358681009897 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 358681009898 non-ribosomal peptide synthase domain TIGR01720; Region: NRPS-para261 358681009899 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 358681009900 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 358681009901 Coenzyme A binding pocket [chemical binding]; other site 358681009902 YycC-like protein; Region: YycC; pfam14174 358681009903 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966 358681009904 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 358681009905 catalytic residues [active] 358681009906 Cytochrome c biogenesis protein [Posttranslational modification, protein turnover, chaperones]; Region: CcdA; COG0785 358681009907 Cytochrome C biogenesis protein transmembrane region; Region: DsbD; pfam02683 358681009908 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 358681009909 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 358681009910 HlyD family secretion protein; Region: HlyD_3; pfam13437 358681009911 Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841 358681009912 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 358681009913 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 358681009914 putative DNA binding site [nucleotide binding]; other site 358681009915 putative Zn2+ binding site [ion binding]; other site 358681009916 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 358681009917 cytochrome b558/566, subunit B; Region: sulfolob_CbsB; TIGR03155 358681009918 Histidine kinase; Region: HisKA_3; pfam07730 358681009919 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 358681009920 ATP binding site [chemical binding]; other site 358681009921 Mg2+ binding site [ion binding]; other site 358681009922 G-X-G motif; other site 358681009923 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 358681009924 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 358681009925 active site 358681009926 phosphorylation site [posttranslational modification] 358681009927 intermolecular recognition site; other site 358681009928 dimerization interface [polypeptide binding]; other site 358681009929 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 358681009930 DNA binding residues [nucleotide binding] 358681009931 dimerization interface [polypeptide binding]; other site 358681009932 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 358681009933 Signal transduction histidine kinase, nitrogen specific [Signal transduction mechanisms]; Region: NtrB; COG3852 358681009934 putative active site [active] 358681009935 heme pocket [chemical binding]; other site 358681009936 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 358681009937 dimer interface [polypeptide binding]; other site 358681009938 phosphorylation site [posttranslational modification] 358681009939 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 358681009940 ATP binding site [chemical binding]; other site 358681009941 Mg2+ binding site [ion binding]; other site 358681009942 G-X-G motif; other site 358681009943 Antibiotic biosynthesis monooxygenase; Region: ABM; pfam03992 358681009944 Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5-; Region: TMP_TenI; cd00564 358681009945 thiamine phosphate binding site [chemical binding]; other site 358681009946 active site 358681009947 pyrophosphate binding site [ion binding]; other site 358681009948 Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5-; Region: TMP_TenI; cd00564 358681009949 thiamine phosphate binding site [chemical binding]; other site 358681009950 active site 358681009951 pyrophosphate binding site [ion binding]; other site 358681009952 Protein of unknown function (DUF3054); Region: DUF3054; pfam11255 358681009953 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 358681009954 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 358681009955 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3333 358681009956 Tripartite tricarboxylate transporter TctB family; Region: TctB; pfam07331 358681009957 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3181 358681009958 Response regulator of citrate/malate metabolism [Transcription / Signal transduction mechanisms]; Region: CitB; COG4565 358681009959 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 358681009960 active site 358681009961 phosphorylation site [posttranslational modification] 358681009962 intermolecular recognition site; other site 358681009963 dimerization interface [polypeptide binding]; other site 358681009964 Signal transduction histidine kinase regulating citrate/malate metabolism [Signal transduction mechanisms]; Region: CitA; COG3290 358681009965 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 358681009966 putative active site [active] 358681009967 heme pocket [chemical binding]; other site 358681009968 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 358681009969 ATP binding site [chemical binding]; other site 358681009970 Mg2+ binding site [ion binding]; other site 358681009971 G-X-G motif; other site 358681009972 uncharacterized nucleobase-cation-symport-1 (NCS1) transporter subfamily, YbbW-like; solute-binding domain; Region: SLC-NCS1sbd_YbbW-like; cd11485 358681009973 Permease for cytosine/purines, uracil, thiamine, allantoin; Region: Transp_cyt_pur; pfam02133 358681009974 Na binding site [ion binding]; other site 358681009975 putative substrate binding site [chemical binding]; other site 358681009976 mammalian-like beta-alanine synthase (beta-AS) and similar proteins (class 5 nitrilases); Region: ML_beta-AS_like; cd07568 358681009977 N-carbamoylputrescine amidase; Region: agmatine_aguB; TIGR03381 358681009978 putative active site [active] 358681009979 catalytic triad [active] 358681009980 multimer interface [polypeptide binding]; other site 358681009981 dimer interface [polypeptide binding]; other site 358681009982 phenylhydantoinase; Validated; Region: PRK08323 358681009983 D-hydantoinases (D-HYD) also called dihydropyrimidases (DHPase) and related proteins; DHPases are a family of enzymes that catalyze the reversible hydrolytic ring opening of the amide bond in five- or six-membered cyclic diamides, like dihydropyrimidine...; Region: D-HYD; cd01314 358681009984 tetramer interface [polypeptide binding]; other site 358681009985 active site 358681009986 dihydropyrimidine dehydrogenase subunit B; Validated; Region: PRK08318 358681009987 Dihydropyrimidine dehydrogenase (DHPD) FMN-binding domain. DHPD catalyzes the first step in pyrimidine degradation: the NADPH-dependent reduction of uracil and thymine to the corresponding 5,6-dihydropyrimidines. DHPD contains two FAD, two FMN, and...; Region: DHPD_FMN; cd02940 358681009988 homodimer interface [polypeptide binding]; other site 358681009989 active site 358681009990 FMN binding site [chemical binding]; other site 358681009991 substrate binding site [chemical binding]; other site 358681009992 4Fe-4S binding domain; Region: Fer4; pfam00037 358681009993 dihydropyrimidine dehydrogenase subunit A; Provisional; Region: PRK11749 358681009994 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 358681009995 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 358681009996 Possible lysine decarboxylase; Region: Lysine_decarbox; cl00695 358681009997 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain superfamily; Region: NTP-PPase; cd11523 358681009998 metal binding site [ion binding]; metal-binding site 358681009999 aminotransferase; Validated; Region: PRK07678 358681010000 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 358681010001 inhibitor-cofactor binding pocket; inhibition site 358681010002 pyridoxal 5'-phosphate binding site [chemical binding]; other site 358681010003 catalytic residue [active] 358681010004 Methylmalonate semialdehyde dehydrogenase and ALDH family members 6A1 and 6B2; Region: ALDH_F6_MMSDH; cd07085 358681010005 methylmalonic acid semialdehyde dehydrogenase; Region: MMSDH; TIGR01722 358681010006 tetrameric interface [polypeptide binding]; other site 358681010007 NAD binding site [chemical binding]; other site 358681010008 catalytic residues [active] 358681010009 Purine catabolism regulatory protein-like family; Region: PucR; pfam07905 358681010010 Sugar diacid utilization regulator [Transcription / Signal transduction mechanisms]; Region: CdaR; COG3835 358681010011 PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556 358681010012 Subtilisin-like serine proteases [Posttranslational modification, protein turnover, chaperones]; Region: AprE; COG1404 358681010013 Peptidase S8 family domain in Kp43 proteases; Region: Peptidases_S8_Kp43_protease; cd04842 358681010014 active site 358681010015 catalytic triad [active] 358681010016 Bacterial pre-peptidase C-terminal domain; Region: PPC; pfam04151 358681010017 stage V sporulation protein K; Region: spore_V_K; TIGR02881 358681010018 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 358681010019 Walker A motif; other site 358681010020 ATP binding site [chemical binding]; other site 358681010021 Walker B motif; other site 358681010022 arginine finger; other site 358681010023 stage V sporulation protein K; Region: spore_V_K; TIGR02881 358681010024 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 358681010025 Walker A motif; other site 358681010026 ATP binding site [chemical binding]; other site 358681010027 Walker B motif; other site 358681010028 arginine finger; other site 358681010029 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 358681010030 Major Facilitator Superfamily; Region: MFS_1; pfam07690 358681010031 putative substrate translocation pore; other site 358681010032 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 358681010033 MarR family; Region: MarR; pfam01047 358681010034 Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841 358681010035 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 358681010036 YjbD family (DUF3811); Region: DUF3811; cl08125 358681010037 HlyD family secretion protein; Region: HlyD_3; pfam13437 358681010038 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 358681010039 H+ Antiporter protein; Region: 2A0121; TIGR00900 358681010040 putative substrate translocation pore; other site 358681010041 Condensation domain; Region: Condensation; pfam00668 358681010042 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 358681010043 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 358681010044 acyl-activating enzyme (AAE) consensus motif; other site 358681010045 AMP binding site [chemical binding]; other site 358681010046 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 358681010047 Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318 358681010048 The adenylation domain of nonribosomal peptide synthetases (NRPS) similar to mycosubtilin synthase subunit A (MycA); Region: A_NRPS_MycA_like; cd05908 358681010049 acyl-activating enzyme (AAE) consensus motif; other site 358681010050 putative AMP binding site [chemical binding]; other site 358681010051 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 358681010052 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 358681010053 Beta-ketoacyl synthase; Region: PKS_KS; smart00825 358681010054 active site 358681010055 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 358681010056 Glutamate-1-semialdehyde aminotransferase [Coenzyme metabolism]; Region: HemL; COG0001 358681010057 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 358681010058 inhibitor-cofactor binding pocket; inhibition site 358681010059 pyridoxal 5'-phosphate binding site [chemical binding]; other site 358681010060 catalytic residue [active] 358681010061 Condensation domain; Region: Condensation; pfam00668 358681010062 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 358681010063 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 358681010064 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 358681010065 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 358681010066 Condensation domain; Region: Condensation; pfam00668 358681010067 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 358681010068 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 358681010069 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 358681010070 acyl-activating enzyme (AAE) consensus motif; other site 358681010071 AMP binding site [chemical binding]; other site 358681010072 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 358681010073 Condensation domain; Region: Condensation; pfam00668 358681010074 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 358681010075 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 358681010076 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 358681010077 acyl-activating enzyme (AAE) consensus motif; other site 358681010078 AMP binding site [chemical binding]; other site 358681010079 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 358681010080 Condensation domain; Region: Condensation; pfam00668 358681010081 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 358681010082 non-ribosomal peptide synthase domain TIGR01720; Region: NRPS-para261 358681010083 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 358681010084 active site 358681010085 metal binding site [ion binding]; metal-binding site 358681010086 Nitroreductase-like family 1. A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes, nitrofurans and...; Region: Nitroreductase_1; cd02137 358681010087 dimer interface [polypeptide binding]; other site 358681010088 FMN binding site [chemical binding]; other site 358681010089 DNA gyrase subunit A; Validated; Region: PRK05560 358681010090 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187 358681010091 CAP-like domain; other site 358681010092 active site 358681010093 primary dimer interface [polypeptide binding]; other site 358681010094 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 358681010095 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 358681010096 DNA gyrase subunit B; Validated; Region: gyrB; PRK05644 358681010097 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 358681010098 Mg2+ binding site [ion binding]; other site 358681010099 G-X-G motif; other site 358681010100 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822 358681010101 anchoring element; other site 358681010102 dimer interface [polypeptide binding]; other site 358681010103 ATP binding site [chemical binding]; other site 358681010104 Topoisomerase-primase domain. This is a nucleotidyl transferase/hydrolase domain found in type IA, type IIA and type IIB topoisomerases, bacterial DnaG-type primases, small primase-like proteins from bacteria and archaea, OLD family nucleases from...; Region: TOPRIM; cl00718 358681010105 active site 358681010106 metal binding site [ion binding]; metal-binding site 358681010107 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 358681010108 Heat induced stress protein YflT; Region: YflT; pfam11181 358681010109 ABC-2 family transporter protein; Region: ABC2_membrane_2; pfam12679 358681010110 ABC-2 family transporter protein; Region: ABC2_membrane_3; pfam12698 358681010111 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 358681010112 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 358681010113 Walker A/P-loop; other site 358681010114 ATP binding site [chemical binding]; other site 358681010115 Q-loop/lid; other site 358681010116 ABC transporter signature motif; other site 358681010117 Walker B; other site 358681010118 D-loop; other site 358681010119 H-loop/switch region; other site 358681010120 tol-pal system beta propeller repeat protein TolB; Region: propeller_TolB; TIGR02800 358681010121 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 358681010122 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 358681010123 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 358681010124 DNA binding residues [nucleotide binding] 358681010125 Cystathionine beta-lyases/cystathionine gamma-synthases [Amino acid transport and metabolism]; Region: MetC; COG0626 358681010126 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 358681010127 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 358681010128 catalytic residue [active] 358681010129 cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the...; Region: cyclophilin; cd00317 358681010130 active site 358681010131 Cell Wall Hydrolase; Region: Hydrolase_2; pfam07486 358681010132 Protein of unknown function (DUF1811); Region: DUF1811; pfam08838 358681010133 Predicted membrane protein [Function unknown]; Region: COG2707 358681010134 Iron-sulphur cluster biosynthesis; Region: Fe-S_biosyn; cl00400 358681010135 Protein of unknown function (DUF2515); Region: DUF2515; pfam10720 358681010136 hypothetical protein; Provisional; Region: PRK13668 358681010137 Protein of unknown function (DUF3900); Region: DUF3900; pfam13039 358681010138 Domain of unknown function (DUF3898); Region: DUF3898; pfam13037 358681010139 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 358681010140 Catalytic domain of Protein Kinases; Region: PKc; cd00180 358681010141 active site 358681010142 ATP binding site [chemical binding]; other site 358681010143 substrate binding site [chemical binding]; other site 358681010144 activation loop (A-loop); other site 358681010145 ATP-dependent RNA helicase RhlB; Provisional; Region: PRK04837 358681010146 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 358681010147 ATP binding site [chemical binding]; other site 358681010148 Mg++ binding site [ion binding]; other site 358681010149 motif III; other site 358681010150 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 358681010151 nucleotide binding region [chemical binding]; other site 358681010152 ATP-binding site [chemical binding]; other site 358681010153 Predicted periplasmic protein (DUF2233); Region: DUF2233; pfam09992 358681010154 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 358681010155 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 358681010156 Walker A/P-loop; other site 358681010157 ATP binding site [chemical binding]; other site 358681010158 Q-loop/lid; other site 358681010159 ABC transporter signature motif; other site 358681010160 Walker B; other site 358681010161 D-loop; other site 358681010162 H-loop/switch region; other site 358681010163 ABC transporter; Region: ABC_tran_2; pfam12848 358681010164 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 358681010165 Spo0E like sporulation regulatory protein; Region: SpoOE-like; pfam09388 358681010166 dihydrolipoamide dehydrogenase; Reviewed; Region: PRK06416 358681010167 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 358681010168 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 358681010169 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 358681010170 branched-chain alpha-keto acid dehydrogenase subunit E2; Reviewed; Region: PRK11856 358681010171 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 358681010172 E3 interaction surface; other site 358681010173 lipoyl attachment site [posttranslational modification]; other site 358681010174 e3 binding domain; Region: E3_binding; pfam02817 358681010175 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 358681010176 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit [Energy production and conversion]; Region: AcoB; COG0022 358681010177 Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036 358681010178 alpha subunit interface [polypeptide binding]; other site 358681010179 TPP binding site [chemical binding]; other site 358681010180 heterodimer interface [polypeptide binding]; other site 358681010181 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 358681010182 pyruvate dehydrogenase E1 component, alpha subunit; Region: PDH_E1_alph_x; TIGR03181 358681010183 Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000 358681010184 TPP-binding site [chemical binding]; other site 358681010185 heterodimer interface [polypeptide binding]; other site 358681010186 tetramer interface [polypeptide binding]; other site 358681010187 phosphorylation loop region [posttranslational modification] 358681010188 Predicted hydrolase of the alpha/beta superfamily [General function prediction only]; Region: COG2819 358681010189 Putative esterase; Region: Esterase; pfam00756 358681010190 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 358681010191 The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504 358681010192 peptide binding site [polypeptide binding]; other site 358681010193 Low-specificity threonine aldolase (TA). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). TA catalyzes the conversion of L-threonine or L-allo-threonine to glycine and acetaldehyde in a...; Region: TA_like; cd06502 358681010194 Beta-eliminating lyase; Region: Beta_elim_lyase; pfam01212 358681010195 tetramer interface [polypeptide binding]; other site 358681010196 pyridoxal 5'-phosphate binding site [chemical binding]; other site 358681010197 catalytic residue [active] 358681010198 Iron-sulphur cluster biosynthesis; Region: Fe-S_biosyn; cl00400 358681010199 Superfamily I DNA and RNA helicases [General function prediction only]; Region: COG3973 358681010200 Part of AAA domain; Region: AAA_19; pfam13245 358681010201 Family description; Region: UvrD_C_2; pfam13538 358681010202 Integral membrane protein possibly involved in chromosome condensation [Cell division and chromosome partitioning]; Region: CrcB; COG0239 358681010203 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 358681010204 LexA repressor; Validated; Region: PRK00215 358681010205 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 358681010206 putative Zn2+ binding site [ion binding]; other site 358681010207 putative DNA binding site [nucleotide binding]; other site 358681010208 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 358681010209 Catalytic site [active] 358681010210 Protein of unknown function (DUF456); Region: DUF456; pfam04306 358681010211 Domain of unknown function (DUF4269); Region: DUF4269; pfam14091 358681010212 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 358681010213 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 358681010214 Coenzyme A binding pocket [chemical binding]; other site 358681010215 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 358681010216 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 358681010217 putative substrate translocation pore; other site 358681010218 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 358681010219 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 358681010220 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 358681010221 Coenzyme A binding pocket [chemical binding]; other site 358681010222 Mor transcription activator family; Region: Mor; cl02360 358681010223 Fibronectin-binding protein (FBP); Region: FBP; pfam07299 358681010224 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643 358681010225 hydrophobic ligand binding site; other site 358681010226 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 358681010227 dimerization interface [polypeptide binding]; other site 358681010228 putative DNA binding site [nucleotide binding]; other site 358681010229 putative Zn2+ binding site [ion binding]; other site 358681010230 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 358681010231 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 358681010232 NAD(P) binding site [chemical binding]; other site 358681010233 active site 358681010234 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 358681010235 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 358681010236 ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614 358681010237 Periplasmic binding protein FeuA. These proteins have predicted to function as initial receptors in ABC transport of metal ions in some eubacterial species. They belong to the TroA superfamily of periplasmic metal binding proteins that share a distinct...; Region: FeuA; cd01138 358681010238 putative ligand binding residues [chemical binding]; other site 358681010239 Conserved protein/domain typically associated with flavoprotein oxygenases, DIM6/NTAB family [General function prediction only]; Region: COG1853 358681010240 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 358681010241 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 358681010242 Helix-Turn-Helix DNA binding domain of the MerR-like transcription regulators YyaN and YraB; Region: HTH_YyaN; cd01109 358681010243 DNA binding residues [nucleotide binding] 358681010244 putative dimer interface [polypeptide binding]; other site 358681010245 Pleckstrin homology (PH)-like domains in bacteria (PHb); Region: PH-like_bacteria; cd13225 358681010246 pentamer interface [polypeptide binding]; other site 358681010247 dodecaamer interface [polypeptide binding]; other site 358681010248 Domain of Unknown Function (DUF1259); Region: DUF1529; pfam07485 358681010249 Domain of unknown function (DUF4062); Region: DUF4062; pfam13271 358681010250 Low molecular weight phosphatase family; Region: LMWPc; cd00115 358681010251 Low molecular weight phosphotyrosine protein phosphatase; Region: LMWPc; pfam01451 358681010252 active site 358681010253 Arsenite efflux pump ACR3 and related permeases [Inorganic ion transport and metabolism]; Region: ACR3; COG0798 358681010254 arsenical-resistance protein; Region: acr3; TIGR00832 358681010255 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_20; cd07254 358681010256 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 358681010257 putative metal binding site [ion binding]; other site 358681010258 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 358681010259 dimerization interface [polypeptide binding]; other site 358681010260 putative DNA binding site [nucleotide binding]; other site 358681010261 putative Zn2+ binding site [ion binding]; other site 358681010262 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 358681010263 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 358681010264 Transcriptional regulator C-terminal region; Region: TetR_C_8; pfam14278 358681010265 Short-chain dehydrogenase involved in D-alanine esterification of lipoteichoic acid and wall teichoic acid (D-alanine transfer protein) [Cell envelope biogenesis, outer membrane]; Region: DltE; COG3967 358681010266 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 358681010267 NAD(P) binding site [chemical binding]; other site 358681010268 active site 358681010269 Type 1 glutamine amidotransferase (GATase1)-like domain found in a subgroup of proteins similar to PfpI from Pyrococcus furiosus; Region: GATase1_PfpI_2; cd03139 358681010270 conserved cys residue [active] 358681010271 Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GAT_1; cl00020 358681010272 potential frameshift: common BLAST hit: gi|52141786|ref|YP_085044.1| phage integrase 358681010273 Integrase [DNA replication, recombination, and repair]; Region: XerC; COG0582 358681010274 phiLC3 phage and phage-related integrases, site-specific recombinases, DNA breaking-rejoining enzymes, C-terminal catalytic domain. This CD includes various bacterial (mainly gram positive) and phage integrases, including those similar to Lactococcus...; Region: INT_phiLC3_C; cd01189 358681010275 Int/Topo IB signature motif; other site 358681010276 Uncharacterized ACR, COG2135; Region: DUF159; pfam02586 358681010277 YolD-like protein; Region: YolD; pfam08863 358681010278 aspartate racemase; Region: asp_race; TIGR00035 358681010279 Asp/Glu/Hydantoin racemase; Region: Asp_Glu_race; cl00518 358681010280 Mannosyl-glycoprotein endo-beta-N-acetylglucosaminidase; Region: Glucosaminidase; cl17361 358681010281 Glutamine synthetase [Amino acid transport and metabolism]; Region: GlnA; COG0174 358681010282 Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951 358681010283 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 358681010284 Helix-Turn-Helix DNA binding domain of GlnR-like transcription regulators; Region: HTH_GlnR-like; cd01105 358681010285 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 358681010286 DNA binding residues [nucleotide binding] 358681010287 putative dimer interface [polypeptide binding]; other site 358681010288 Cystathionine beta-lyase family protein involved in aluminum resistance [Inorganic ion transport and metabolism]; Region: COG4100 358681010289 Aluminium resistance protein; Region: Alum_res; pfam06838 358681010290 GTP-binding protein HflX; Region: GTP_HflX; TIGR03156 358681010291 GTP-binding GTPase N-terminal; Region: GTP-bdg_N; pfam13167 358681010292 HflX GTPase family; Region: HflX; cd01878 358681010293 G1 box; other site 358681010294 GTP/Mg2+ binding site [chemical binding]; other site 358681010295 Switch I region; other site 358681010296 G2 box; other site 358681010297 G3 box; other site 358681010298 Switch II region; other site 358681010299 G4 box; other site 358681010300 G5 box; other site 358681010301 RNA ligase; Region: RNA_ligase; pfam09414 358681010302 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 358681010303 Transposase; Region: HTH_Tnp_1; pfam01527 358681010304 putative transposase OrfB; Reviewed; Region: PHA02517 358681010305 HTH-like domain; Region: HTH_21; pfam13276 358681010306 Integrase core domain; Region: rve; pfam00665 358681010307 Integrase core domain; Region: rve_3; pfam13683 358681010308 stage V sporulation protein K; Region: spore_V_K; TIGR02881 358681010309 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 358681010310 Walker A motif; other site 358681010311 ATP binding site [chemical binding]; other site 358681010312 Walker B motif; other site 358681010313 arginine finger; other site 358681010314 Domain of unknown function (DUF4184); Region: DUF4184; pfam13803 358681010315 Translation initiation factor 3 (IF-3) [Translation, ribosomal structure and biogenesis]; Region: InfC; COG0290 358681010316 Translation initiation factor IF-3, N-terminal domain; Region: IF3_N; pfam05198 358681010317 Translation initiation factor IF-3, C-terminal domain; Region: IF3_C; pfam00707 358681010318 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 358681010319 MarR family; Region: MarR; pfam01047 358681010320 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 358681010321 bicyclomycin/multidrug efflux system; Provisional; Region: PRK11102 358681010322 putative substrate translocation pore; other site 358681010323 Escherichia coli PhnB and similar proteins; the E. coli phnB gene is found next to an operon involved in the cleavage of carbon-phosphorus bonds in unactivated alkylphosphonates; Region: PhnB_like; cd06588 358681010324 dimer interface [polypeptide binding]; other site 358681010325 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 358681010326 bacterial Hfq-like; Region: Hfq; cd01716 358681010327 hexamer interface [polypeptide binding]; other site 358681010328 Sm1 motif; other site 358681010329 RNA binding site [nucleotide binding]; other site 358681010330 Sm2 motif; other site 358681010331 tRNA delta(2)-isopentenylpyrophosphate transferase; Reviewed; Region: miaA; PRK00091 358681010332 tRNA delta(2)-isopentenylpyrophosphate transferase [Translation, ribosomal structure and biogenesis]; Region: MiaA; COG0324 358681010333 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 358681010334 S-adenosylmethionine binding site [chemical binding]; other site 358681010335 superfamily containing globins and truncated hemoglobins; Region: globin_like; cl00280 358681010336 heme-binding site [chemical binding]; other site 358681010337 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 358681010338 dimer interface [polypeptide binding]; other site 358681010339 putative CheW interface [polypeptide binding]; other site 358681010340 Phosphotransferase enzyme family; Region: APH; pfam01636 358681010341 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cd05120 358681010342 active site 358681010343 substrate binding site [chemical binding]; other site 358681010344 ATP binding site [chemical binding]; other site 358681010345 DNA mismatch repair protein; Reviewed; Region: mutL; PRK00095 358681010346 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 358681010347 ATP binding site [chemical binding]; other site 358681010348 Mg2+ binding site [ion binding]; other site 358681010349 G-X-G motif; other site 358681010350 MutL_Trans: transducer domain, having a ribosomal S5 domain 2-like fold, conserved in the C-terminal domain of DNA mismatch repair (MutL/MLH1/PMS2) family. This transducer domain is homologous to the second domain of the DNA gyrase B subunit, which is...; Region: MutL_Trans; cd00782 358681010351 ATP binding site [chemical binding]; other site 358681010352 MutL C terminal dimerisation domain; Region: MutL_C; pfam08676 358681010353 DNA mismatch repair protein MutS; Provisional; Region: PRK05399 358681010354 MutS domain I; Region: MutS_I; pfam01624 358681010355 MutS domain II; Region: MutS_II; pfam05188 358681010356 MutS domain III; Region: MutS_III; pfam05192 358681010357 ATP-binding cassette domain of MutS1 homolog; Region: ABC_MutS1; cd03284 358681010358 Walker A/P-loop; other site 358681010359 ATP binding site [chemical binding]; other site 358681010360 Q-loop/lid; other site 358681010361 ABC transporter signature motif; other site 358681010362 Walker B; other site 358681010363 D-loop; other site 358681010364 H-loop/switch region; other site 358681010365 Phage phiEco32-like COOH.NH2 ligase-type 2; Region: COOH-NH2_lig; pfam14395 358681010366 Outer spore coat protein E (CotE); Region: CotE; pfam10628 358681010367 Predicted membrane protein [Function unknown]; Region: COG4550 358681010368 (dimethylallyl)adenosine tRNA methylthiotransferase; Provisional; Region: PRK14327 358681010369 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 358681010370 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 358681010371 FeS/SAM binding site; other site 358681010372 TRAM domain; Region: TRAM; pfam01938 358681010373 S-layer homology domain; Region: SLH; pfam00395 358681010374 S-layer homology domain; Region: SLH; pfam00395 358681010375 Lipoate-protein ligase A [Coenzyme metabolism]; Region: LplA; COG0095 358681010376 Acyltransferase family; Region: Acyl_transf_3; pfam01757 358681010377 Predicted O-acyltransferase [General function prediction only]; Region: COG3274 358681010378 FOG: CBS domain [General function prediction only]; Region: COG0517 358681010379 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair_30; cd04643 358681010380 YheC/D like ATP-grasp; Region: ATPgrasp_YheCD; pfam14398 358681010381 Methyltransferase domain; Region: Methyltransf_31; pfam13847 358681010382 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 358681010383 S-adenosylmethionine binding site [chemical binding]; other site 358681010384 Metal-dependent hydrolases of the beta-lactamase superfamily III [General function prediction only]; Region: ElaC; COG1234 358681010385 Uncharacterized membrane protein [Function unknown]; Region: COG3949 358681010386 2-oxoglutarate ferredoxin oxidoreductase subunit beta; Reviewed; Region: PRK11867 358681010387 Thiamine pyrophosphate (TPP family), 2-oxoglutarate ferredoxin oxidoreductase (OGFOR) subfamily, TPP-binding module; OGFOR catalyzes the oxidative decarboxylation of 2-oxo-acids, with ferredoxin acting as an electron acceptor. In the TCA cycle, OGFOR...; Region: TPP_OGFOR; cd03375 358681010388 TPP-binding site [chemical binding]; other site 358681010389 Pyruvate ferredoxin oxidoreductase beta subunit C terminal; Region: PFO_beta_C; pfam12367 358681010390 2-oxoacid:acceptor oxidoreductase, alpha subunit; Region: OAFO_sf; TIGR03710 358681010391 Pyruvate:ferredoxin oxidoreductase and related 2-oxoacid:ferredoxin oxidoreductases, gamma subunit [Energy production and conversion]; Region: PorG; COG1014 358681010392 Pyrimidine (PYR) binding domain of pyruvate ferredoxin oxidoreductase (PFOR), indolepyruvate ferredoxin oxidoreductase alpha subunit (IOR-alpha), and related proteins; Region: TPP_PYR_PFOR_IOR-alpha_like; cd07034 358681010393 dimer interface [polypeptide binding]; other site 358681010394 PYR/PP interface [polypeptide binding]; other site 358681010395 TPP binding site [chemical binding]; other site 358681010396 substrate binding site [chemical binding]; other site 358681010397 Zn-dependent dipeptidase, microsomal dipeptidase homolog [Amino acid transport and metabolism]; Region: COG2355 358681010398 renal dipeptidase (rDP), best studied in mammals and also called membrane or microsomal dipeptidase, is a membrane-bound glycoprotein hydrolyzing dipeptides and is involved in hydrolytic metabolism of penem and carbapenem beta-lactam antibiotics; Region: rDP_like; cd01301 358681010399 active site 358681010400 dimer interface [polypeptide binding]; other site 358681010401 Stage V sporulation protein S (SpoVS); Region: SpoVS; pfam04232 358681010402 Deinococcus radiodurans DR1281 and related proteins, metallophosphatase domain; Region: MPP_DR1281; cd07382 358681010403 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 358681010404 putative active site [active] 358681010405 metal binding site [ion binding]; metal-binding site 358681010406 homodimer binding site [polypeptide binding]; other site 358681010407 Domain of unknown function (DUF3552); Region: DUF3552; pfam12072 358681010408 Predicted HD superfamily hydrolase [General function prediction only]; Region: COG1418 358681010409 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 358681010410 Zn2+ binding site [ion binding]; other site 358681010411 Mg2+ binding site [ion binding]; other site 358681010412 RecX family; Region: RecX; cl00936 358681010413 recombinase A; Provisional; Region: recA; PRK09354 358681010414 RecA is a bacterial enzyme which has roles in homologous recombination, DNA repair, and the induction of the SOS response. RecA couples ATP hydrolysis to DNA strand exchange; Region: recA; cd00983 358681010415 hexamer interface [polypeptide binding]; other site 358681010416 Walker A motif; other site 358681010417 ATP binding site [chemical binding]; other site 358681010418 Walker B motif; other site 358681010419 Superfamily II DNA and RNA helicases [DNA replication, recombination, and repair / Transcription / Translation, ribosomal structure and biogenesis]; Region: SrmB; COG0513 358681010420 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 358681010421 ATP binding site [chemical binding]; other site 358681010422 Mg++ binding site [ion binding]; other site 358681010423 motif III; other site 358681010424 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 358681010425 nucleotide binding region [chemical binding]; other site 358681010426 ATP-binding site [chemical binding]; other site 358681010427 RNA recognition motif in the DbpA subfamily of prokaryotic DEAD-box rRNA helicases; Region: RRM_DbpA; cd12252 358681010428 RNA binding site [nucleotide binding]; other site 358681010429 competence damage-inducible protein A; Provisional; Region: PRK00549 358681010430 Competence-damaged protein. CinA is the first gene in the competence- inducible (cin) operon and is thought to be specifically required at some stage in the process of transformation. This domain is closely related to a domain, found in a variety of...; Region: cinA; cd00885 358681010431 putative MPT binding site; other site 358681010432 Competence-damaged protein; Region: CinA; pfam02464 358681010433 CDP-diacylglycerol--glycerol-3-phosphate 3-phosphatidyltransferase; Region: pgsA; TIGR00560 358681010434 2-methylthioadenine synthetase [Translation, ribosomal structure and biogenesis]; Region: MiaB; COG0621 358681010435 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 358681010436 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 358681010437 FeS/SAM binding site; other site 358681010438 TRAM domain; Region: TRAM; cl01282 358681010439 Predicted transcriptional regulator contains Xre-like HTH domain [Function unknown]; Region: COG1426 358681010440 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 358681010441 non-specific DNA binding site [nucleotide binding]; other site 358681010442 salt bridge; other site 358681010443 sequence-specific DNA binding site [nucleotide binding]; other site 358681010444 Domain of unknown function (DUF4115); Region: DUF4115; pfam13464 358681010445 ACT domain; Region: ACT; pfam01842 358681010446 Protein of unknown function (DUF3388); Region: DUF3388; pfam11868 358681010447 Protein of unknown function (DUF3243); Region: DUF3243; pfam11588 358681010448 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK05565 358681010449 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 358681010450 NAD(P) binding site [chemical binding]; other site 358681010451 active site 358681010452 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 358681010453 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 358681010454 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 358681010455 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 358681010456 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 358681010457 Copper amine oxidase N-terminal domain; Region: Cu_amine_oxidN1; pfam07833 358681010458 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 358681010459 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 358681010460 Peptidase family M23; Region: Peptidase_M23; pfam01551 358681010461 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 358681010462 Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette; Region: TM_PBP1_transp_TpRbsC_like; cd06580 358681010463 TM-ABC transporter signature motif; other site 358681010464 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 358681010465 Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette; Region: TM_PBP1_transp_TpRbsC_like; cd06580 358681010466 TM-ABC transporter signature motif; other site 358681010467 ABC-type uncharacterized transport systems, ATPase components [General function prediction only]; Region: COG3845 358681010468 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 358681010469 Walker A/P-loop; other site 358681010470 ATP binding site [chemical binding]; other site 358681010471 Q-loop/lid; other site 358681010472 ABC transporter signature motif; other site 358681010473 Walker B; other site 358681010474 D-loop; other site 358681010475 H-loop/switch region; other site 358681010476 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 358681010477 Uncharacterized ABC-type transport system, periplasmic component/surface lipoprotein [General function prediction only]; Region: Med; COG1744 358681010478 Periplasmic binding domain of basic membrane lipoprotein, PnrA, in Treponema pallidum and its homologs from other bacteria and Archaea; Region: PBP1_BmpA_PnrA_like; cd06354 358681010479 ligand binding site [chemical binding]; other site 358681010480 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 358681010481 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 358681010482 DNA-binding site [nucleotide binding]; DNA binding site 358681010483 UTRA domain; Region: UTRA; pfam07702 358681010484 DNA segregation ATPase FtsK/SpoIIIE and related proteins [Cell division and chromosome partitioning]; Region: FtsK; COG1674 358681010485 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 358681010486 Ftsk gamma domain; Region: Ftsk_gamma; pfam09397 358681010487 YlzJ-like protein; Region: YlzJ; pfam14035 358681010488 Protease subunit of ATP-dependent Clp proteases [Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: ClpP; COG0740 358681010489 Caseinolytic protease (ClpP) is an ATP-dependent protease; Region: Clp_protease_like; cl15763 358681010490 active site 358681010491 mRNA degradation ribonucleases J1/J2 (metallo-beta-lactamase superfamily) [Translation, ribosomal structure and biogenesis; Replication, recombination and repair]; Region: COG0595 358681010492 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 358681010493 RNA-metabolising metallo-beta-lactamase; Region: RMMBL; pfam07521 358681010494 Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329 358681010495 Dihydrodipicolinate synthase (DHDPS); Region: DHDPS; cd00950 358681010496 dimer interface [polypeptide binding]; other site 358681010497 active site 358681010498 catalytic residue [active] 358681010499 aspartate kinase I; Reviewed; Region: PRK08210 358681010500 Amino Acid Kinases (AAK) superfamily, catalytic domain; present in such enzymes like N-acetylglutamate kinase (NAGK), carbamate kinase (CK), aspartokinase (AK), glutamate-5-kinase (G5K) and UMP kinase (UMPK). The AAK superfamily includes kinases that...; Region: AAK; cl00452 358681010501 nucleotide binding site [chemical binding]; other site 358681010502 substrate binding site [chemical binding]; other site 358681010503 ACT domains of the diaminopimelate-sensitive aspartokinase (AK) isoenzyme AKI; Region: ACT_AKi-DapG-BS_1; cd04914 358681010504 ACT domains of the diaminopimelate-sensitive aspartokinase (AK) isoenzyme AKI; Region: ACT_AKi-DapG-BS_2; cd04937 358681010505 aspartate-semialdehyde dehydrogenase; Provisional; Region: PRK14874 358681010506 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 358681010507 dipicolinate synthase subunit B; Reviewed; Region: spoVFB; PRK08305 358681010508 dipicolinate synthase subunit A; Reviewed; Region: PRK08306 358681010509 sporulation protein, YlmC/YmxH family; Region: spore_YlmC_YmxH; TIGR02888 358681010510 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 358681010511 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 358681010512 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 358681010513 probable sporulation protein, polysaccharide deacetylase family; Region: spore_ylxY; TIGR02873 358681010514 Putative catalytic NodB homology domain of uncharacterized protein YlxY from Bacillus subtilis and its bacterial homologs; Region: CE4_BsYlxY_like; cd10950 358681010515 NodB motif; other site 358681010516 polynucleotide phosphorylase/polyadenylase; Provisional; Region: PRK11824 358681010517 Polyribonucleotide nucleotidyltransferase, repeat 1; Region: RNase_PH_PNPase_1; cd11363 358681010518 RNase E interface [polypeptide binding]; other site 358681010519 trimer interface [polypeptide binding]; other site 358681010520 Polyribonucleotide nucleotidyltransferase, RNA binding domain; Region: PNPase; pfam03726 358681010521 Polyribonucleotide nucleotidyltransferase, repeat 2; Region: RNase_PH_PNPase_2; cd11364 358681010522 RNase E interface [polypeptide binding]; other site 358681010523 trimer interface [polypeptide binding]; other site 358681010524 active site 358681010525 Polynucleotide phosphorylase (PNPase) K homology RNA-binding domain (KH). PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA in prokaryotes and plant chloroplasts. The C-terminal region of PNPase contains domains homologous to...; Region: PNPase_KH; cd02393 358681010526 putative nucleic acid binding region [nucleotide binding]; other site 358681010527 G-X-X-G motif; other site 358681010528 S1_PNPase: Polynucleotide phosphorylase (PNPase), ), S1-like RNA-binding domain. PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA. It is a trimeric multidomain protein. The C-terminus contains the S1 domain which binds ssRNA; Region: S1_PNPase; cd04472 358681010529 RNA binding site [nucleotide binding]; other site 358681010530 domain interface; other site 358681010531 Ribosomal protein S15 (prokaryotic)_S13 (eukaryotic) binds the central domain of 16S rRNA and is required for assembly of the small ribosomal subunit and for intersubunit association, thus representing a key element in the assembly of the whole ribosome; Region: Ribosomal_S15p_S13e; cd00353 358681010532 16S/18S rRNA binding site [nucleotide binding]; other site 358681010533 S13e-L30e interaction site [polypeptide binding]; other site 358681010534 25S rRNA binding site [nucleotide binding]; other site 358681010535 bifunctional riboflavin kinase/FMN adenylyltransferase; Reviewed; Region: PRK05627 358681010536 FAD synthetase, N-terminal domain of the bifunctional enzyme; Region: FAD_synthetase_N; cd02064 358681010537 active site 358681010538 Riboflavin kinase; Region: Flavokinase; pfam01687 358681010539 tRNA pseudouridine synthase B; Provisional; Region: truB; PRK01550 358681010540 Pseudouridine synthase, Escherichia coli TruB like; Region: PseudoU_synth_EcTruB; cd02573 358681010541 RNA binding site [nucleotide binding]; other site 358681010542 active site 358681010543 Exopolyphosphatase-related proteins [General function prediction only]; Region: COG0618 358681010544 DHH family; Region: DHH; pfam01368 358681010545 DHHA1 domain; Region: DHHA1; pfam02272 358681010546 ribosome-binding factor A; Validated; Region: rbfA; PRK00521 358681010547 Protein of unknown function (DUF503); Region: DUF503; pfam04456 358681010548 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 358681010549 translation initiation factor IF-2; Region: IF-2; TIGR00487 358681010550 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 358681010551 Initiation Factor 2 (IF2)/ eukaryotic Initiation Factor 5B (eIF5B) family; Region: IF2_eIF5B; cd01887 358681010552 G1 box; other site 358681010553 putative GEF interaction site [polypeptide binding]; other site 358681010554 GTP/Mg2+ binding site [chemical binding]; other site 358681010555 Switch I region; other site 358681010556 G2 box; other site 358681010557 G3 box; other site 358681010558 Switch II region; other site 358681010559 G4 box; other site 358681010560 G5 box; other site 358681010561 This family represents the domain II of bacterial Initiation Factor 2 (IF2) and its eukaryotic mitochondrial homologue mtIF2. IF2, the largest initiation factor is an essential GTP binding protein. In E. coli three natural forms of IF2 exist in the cell; Region: IF2_mtIF2_II; cd03702 358681010562 Translation-initiation factor 2; Region: IF-2; pfam11987 358681010563 mtIF2_IVc: this family represents the C2 subdomain of domain IV of mitochondrial translation initiation factor 2 (mtIF2) which adopts a beta-barrel fold displaying a high degree of structural similarity with domain II of the translation elongation factor...; Region: mtIF2_IVc; cd03692 358681010564 Ribosomal protein L7Ae/L30e/S12e/Gadd45 family; Region: Ribosomal_L7Ae; cl00600 358681010565 Ylxr homologs; group of conserved hypothetical bacterial proteins of unknown function; structure revealed putative RNA binding cleft; proteins are encoded by an operon that includes other proteins involved in transcription and/or translation; Region: YlxR; cd00279 358681010566 putative RNA binding cleft [nucleotide binding]; other site 358681010567 transcription elongation factor NusA; Provisional; Region: nusA; PRK12327 358681010568 NusA N-terminal domain; Region: NusA_N; pfam08529 358681010569 S1_NusA: N-utilizing substance A protein (NusA), S1-like RNA-binding domain. S1-like RNA-binding domains are found in a wide variety of RNA-associated proteins. NusA is a transcription elongation factor containing an N-terminal catalytic domain and three...; Region: S1_NusA; cd04455 358681010570 RNA binding site [nucleotide binding]; other site 358681010571 homodimer interface [polypeptide binding]; other site 358681010572 NusA-like KH domain; Region: KH_5; pfam13184 358681010573 NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134 358681010574 G-X-X-G motif; other site 358681010575 ribosome maturation protein RimP; Reviewed; Region: PRK00092 358681010576 Sm and related proteins; Region: Sm_like; cl00259 358681010577 Bacillus subtilis YxlS-like, C-terminal domain; Region: YlxS_C; cd01734 358681010578 putative oligomer interface [polypeptide binding]; other site 358681010579 putative RNA binding site [nucleotide binding]; other site 358681010580 DNA polymerase III PolC; Validated; Region: polC; PRK00448 358681010581 DNA polymerase III polC-type N-terminus; Region: DNA_pol3_alph_N; pfam11490 358681010582 polC_OBF: A subfamily of OB folds corresponding to the N-terminal OB-fold nucleic acid binding domain of Bacillus subtilis type C replicative DNA polymerase III alpha subunit (polC). Replication in B. subtilis and Staphylococcus aureus requires two...; Region: polC_OBF; cd04484 358681010583 generic binding surface II; other site 358681010584 generic binding surface I; other site 358681010585 Polymerase and Histidinol Phosphatase domain; Region: PHP; cl17102 358681010586 active site 358681010587 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 358681010588 active site 358681010589 catalytic site [active] 358681010590 substrate binding site [chemical binding]; other site 358681010591 Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III at PolC gene; Region: PHP_PolIIIA_POLC; cd07435 358681010592 prolyl-tRNA synthetase; Provisional; Region: PRK09194 358681010593 Prolyl-tRNA synthetase (ProRS) class II core catalytic domain. ProRS is a homodimer. It is responsible for the attachment of proline to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ProRS_core_prok; cd00779 358681010594 dimer interface [polypeptide binding]; other site 358681010595 motif 1; other site 358681010596 active site 358681010597 motif 2; other site 358681010598 INS is an amino acid-editing domain inserted (INS) into the bacterial class II prolyl-tRNA synthetase (ProRS) however, this CD is not exclusively bacterial. It is also found at the N-terminus of the eukaryotic/archaea-like ProRS's of yeasts and...; Region: ProRS-INS; cd04334 358681010599 putative deacylase active site [active] 358681010600 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 358681010601 active site 358681010602 motif 3; other site 358681010603 ProRS Prolyl-anticodon binding domain, short version found predominantly in bacteria. ProRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding; Region: ProRS_anticodon_short; cd00861 358681010604 anticodon binding site; other site 358681010605 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Reviewed; Region: ispG; PRK00366 358681010606 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694 358681010607 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694 358681010608 RIP metalloprotease RseP; Region: TIGR00054 358681010609 RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163 358681010610 active site 358681010611 Site-2 protease (S2P) class of zinc metalloproteases (MEROPS family M50) cleaves transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of this family use proteolytic...; Region: S2P-M50; cl10020 358681010612 PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989 358681010613 protein binding site [polypeptide binding]; other site 358681010614 Site-2 protease (S2P) class of zinc metalloproteases (MEROPS family M50) cleaves transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of this family use proteolytic...; Region: S2P-M50; cl10020 358681010615 putative substrate binding region [chemical binding]; other site 358681010616 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Provisional; Region: PRK05447 358681010617 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Region: DXP_reductoisom; pfam02670 358681010618 1-deoxy-D-xylulose 5-phosphate reductoisomerase C-terminal; Region: DXP_redisom_C; pfam08436 358681010619 DXP reductoisomerase C-terminal domain; Region: DXPR_C; pfam13288 358681010620 CDP-diglyceride synthetase [Lipid metabolism]; Region: CdsA; COG0575 358681010621 Cytidylyltransferase family; Region: CTP_transf_1; pfam01148 358681010622 Undecaprenyl pyrophosphate synthase [Lipid metabolism]; Region: UppS; COG0020 358681010623 Cis (Z)-Isoprenyl Diphosphate Synthases (cis-IPPS); homodimers which catalyze the successive 1'-4 condensation of the isopentenyl diphosphate (IPP) molecule to trans,trans-farnesyl diphosphate (FPP) or to cis,trans-FPP to form long-chain polyprenyl...; Region: CIS_IPPS; cd00475 358681010624 catalytic residue [active] 358681010625 putative FPP diphosphate binding site; other site 358681010626 putative FPP binding hydrophobic cleft; other site 358681010627 dimer interface [polypeptide binding]; other site 358681010628 putative IPP diphosphate binding site; other site 358681010629 ribosome recycling factor; Reviewed; Region: frr; PRK00083 358681010630 Ribosome recycling factor (RRF). Ribosome recycling factor dissociates the posttermination complex, composed of the ribosome, deacylated tRNA, and mRNA, after termination of translation. Thus ribosomes are "recycled" and ready for another...; Region: RRF; cd00520 358681010631 hinge region; other site 358681010632 UMP kinase (UMPK)-Ec, the microbial/chloroplast uridine monophosphate kinase (uridylate kinase) enzyme that catalyzes UMP phosphorylation and plays a key role in pyrimidine nucleotide biosynthesis; regulation of this process is via feed-back control and...; Region: AAK_UMPK-PyrH-Ec; cd04254 358681010633 putative nucleotide binding site [chemical binding]; other site 358681010634 uridine monophosphate binding site [chemical binding]; other site 358681010635 homohexameric interface [polypeptide binding]; other site 358681010636 elongation factor Ts; Provisional; Region: tsf; PRK09377 358681010637 UBA/TS-N domain; Region: UBA; pfam00627 358681010638 Elongation factor TS; Region: EF_TS; pfam00889 358681010639 Elongation factor TS; Region: EF_TS; pfam00889 358681010640 Ribosomal protein S2 (RPS2), involved in formation of the translation initiation complex, where it might contact the messenger RNA and several components of the ribosome. It has been shown that in Escherichia coli RPS2 is essential for the binding of...; Region: RPS2; cd01425 358681010641 rRNA interaction site [nucleotide binding]; other site 358681010642 S8 interaction site; other site 358681010643 putative laminin-1 binding site; other site 358681010644 YceG-like family; Region: YceG; pfam02618 358681010645 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cl17257 358681010646 Protein of unknown function (DUF342); Region: DUF342; pfam03961 358681010647 Septum formation inhibitor MinC, C-terminal domain; Region: MinC_C; pfam03775 358681010648 RNA polymerase sigma factor SigD; Validated; Region: PRK07670 358681010649 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 358681010650 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 358681010651 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 358681010652 DNA binding residues [nucleotide binding] 358681010653 chemoreceptor glutamine deamidase CheD; Provisional; Region: PRK13488 358681010654 Chemotaxis protein CheC, inhibitor of MCP methylation [Cell motility and secretion / Signal transduction mechanisms]; Region: CheC; COG1776 358681010655 CheC-like family; Region: CheC; pfam04509 358681010656 CheC-like family; Region: CheC; pfam04509 358681010657 CheW-like domain. CheW proteins are part of the chemotaxis signalling mechanism in bacteria. CheW interacts with the methyl accepting chemotaxis proteins (MCPs) and relays signals to CheY, which affects flageller rotation. This family includes CheW and...; Region: CheW_like; cl00256 358681010658 Chemotaxis protein histidine kinase and related kinases [Cell motility and secretion / Signal transduction mechanisms]; Region: CheA; COG0643 358681010659 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 358681010660 putative binding surface; other site 358681010661 active site 358681010662 P2 response regulator binding domain; Region: P2; pfam07194 358681010663 Signal transducing histidine kinase, homodimeric domain; Region: H-kinase_dim; pfam02895 358681010664 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 358681010665 ATP binding site [chemical binding]; other site 358681010666 Mg2+ binding site [ion binding]; other site 358681010667 G-X-G motif; other site 358681010668 CheA regulatory domain; CheA is a histidine protein kinase present in bacteria and archea. Activated by the chemotaxis receptor a histidine phosphoryl group from CheA is passed directly to an aspartate in the response regulator CheY. This signalling...; Region: CheA_reg; cd00731 358681010669 chemotaxis-specific methylesterase; Provisional; Region: PRK00742 358681010670 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 358681010671 active site 358681010672 phosphorylation site [posttranslational modification] 358681010673 intermolecular recognition site; other site 358681010674 dimerization interface [polypeptide binding]; other site 358681010675 CheB methylesterase; Region: CheB_methylest; pfam01339 358681010676 Antiactivator of flagellar biosynthesis FleN, an ATPase [Cell motility]; Region: flhG; COG0455 358681010677 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 358681010678 FleN is a member of the Fer4_NifH superfamily. It shares the common function as an ATPase, with the ATP-binding domain at the N-terminus. In Pseudomonas aeruginosa, FleN gene is involved in regulating the number of flagella and chemotactic motility by...; Region: FleN-like; cd02038 358681010679 flagellar biosynthesis regulator FlhF; Validated; Region: flhF; PRK05703 358681010680 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 358681010681 flagellar biosynthesis protein FlhA; Validated; Region: flhA; PRK06012 358681010682 FHIPEP family; Region: FHIPEP; pfam00771 358681010683 flagellar biosynthesis protein FlhB; Reviewed; Region: flhB; PRK05702 358681010684 Uncharacterized homolog of the cytoplasmic domain of flagellar protein FhlB [Function unknown]; Region: COG2257 358681010685 flagellar biosynthesis protein FliR; Reviewed; Region: fliR; PRK05701 358681010686 flagellar biosynthesis protein FliQ; Validated; Region: fliQ; PRK05700 358681010687 flagellar biosynthesis protein FliP; Reviewed; Region: fliP; PRK05699 358681010688 Flagellar biosynthesis protein, FliO; Region: FliO; cl01247 358681010689 Response regulator receiver domain; Region: Response_reg; pfam00072 358681010690 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 358681010691 active site 358681010692 phosphorylation site [posttranslational modification] 358681010693 intermolecular recognition site; other site 358681010694 dimerization interface [polypeptide binding]; other site 358681010695 Chemotaxis protein CheC, inhibitor of MCP methylation [Cell motility and secretion / Signal transduction mechanisms]; Region: CheC; COG1776 358681010696 CheC-like family; Region: CheC; pfam04509 358681010697 CheC-like family; Region: CheC; pfam04509 358681010698 flagellar motor switch protein FliN; Region: fliN; TIGR02480 358681010699 flagellar motor switch protein FliM; Validated; Region: fliM; PRK06666 358681010700 Surface presentation of antigens (SPOA); Region: SpoA; pfam01052 358681010701 flagellar basal body-associated protein FliL; Reviewed; Region: fliL; PRK07718 358681010702 Flagellar basal body-associated protein FliL; Region: FliL; cl00681 358681010703 Flagellar protein (FlbD); Region: FlbD; pfam06289 358681010704 flagellar basal body rod protein FlgG; Provisional; Region: flgG; PRK12636 358681010705 Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460 358681010706 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 358681010707 Protein of unknown function (DUF3766); Region: DUF3766; cl11797 358681010708 Flagellar hook-length control protein FliK; Region: Flg_hook; pfam02120 358681010709 Uncharacterized conserved protein [Function unknown]; Region: COG3334 358681010710 flagellar biosynthesis chaperone; Validated; Region: fliJ; PRK07720 358681010711 flagellar export protein FliJ; Region: flagell_FliJ; TIGR02473 358681010712 flagellar protein export ATPase FliI; Region: FliI_clade2; TIGR03497 358681010713 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 358681010714 Flagellum-specific ATPase/type III secretory pathway virulence-related protein. This group of ATPases are responsible for the export of flagellum and virulence-related proteins. The bacterial flagellar motor is similar to the F0F1-ATPase, in that they...; Region: ATPase_flagellum-secretory_path_III; cd01136 358681010715 Walker A motif/ATP binding site; other site 358681010716 Walker B motif; other site 358681010717 flagellar assembly protein FliH; Region: FliH_bacil; TIGR03825 358681010718 Flagellar assembly protein FliH; Region: FliH; pfam02108 358681010719 flagellar motor switch protein G; Validated; Region: fliG; PRK05686 358681010720 FliG C-terminal domain; Region: FliG_C; pfam01706 358681010721 potential frameshift: common BLAST hit: gi|15615021|ref|NP_243324.1| flagellar MS-ring protein 358681010722 flagellar basal-body M-ring protein/flagellar hook-basal body protein (fliF); Region: fliF; TIGR00206 358681010723 Flagellar M-ring protein C-terminal; Region: YscJ_FliF_C; pfam08345 358681010724 Secretory protein of YscJ/FliF family; Region: YscJ_FliF; cl01907 358681010725 Flagellar hook-basal body complex protein FliE; Region: FliE; cl09139 358681010726 flagellar basal body rod protein FlgC; Reviewed; Region: flgC; PRK05681 358681010727 Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460 358681010728 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 358681010729 flagellar basal body rod protein FlgB; Reviewed; Region: flgB; PRK05680 358681010730 flagellar basal body rod protein FlgB; Reviewed; Region: flgB; PRK07182 358681010731 transcriptional repressor CodY; Validated; Region: PRK04158 358681010732 CodY GAF-like domain; Region: CodY; pfam06018 358681010733 CodY helix-turn-helix domain; Region: HTH_CodY; pfam08222 358681010734 ATP-dependent protease ATP-binding subunit HslU; Provisional; Region: hslU; PRK05201 358681010735 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 358681010736 Walker A motif; other site 358681010737 ATP binding site [chemical binding]; other site 358681010738 AAA domain (Cdc48 subfamily); Region: AAA_2; pfam07724 358681010739 Walker B motif; other site 358681010740 arginine finger; other site 358681010741 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 358681010742 Protease HslV and the ATPase/chaperone HslU are part of an ATP-dependent proteolytic system that is the prokaryotic homolog of the proteasome. HslV is a dimer of hexamers (a dodecamer) that forms a central proteolytic chamber with active sites on the...; Region: protease_HslV; cd01913 358681010743 active site 358681010744 HslU subunit interaction site [polypeptide binding]; other site 358681010745 Site-specific recombinase XerD [DNA replication, recombination, and repair]; Region: XerD; COG4974 358681010746 XerD and XerC integrases, DNA breaking-rejoining enzymes, N- and C-terminal domains. XerD-like integrases are involved in the site-specific integration and excision of lysogenic bacteriophage genomes, transposition of conjugative transposons, termination...; Region: INT_XerDC; cd00798 358681010747 active site 358681010748 Int/Topo IB signature motif; other site 358681010749 tRNA (uracil-5-)-methyltransferase Gid; Reviewed; Region: PRK05335 358681010750 Glucose inhibited division protein A; Region: GIDA; pfam01134 358681010751 DNA topoisomerase I; Validated; Region: PRK05582 358681010752 TOPRIM_TopoIA_TopoI: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to Escherichia coli DNA topoisomerase I. Type IA DNA topoisomerases remove (relax) negative supercoils in the...; Region: TOPRIM_TopoIA_TopoI; cd03363 358681010753 active site 358681010754 interdomain interaction site; other site 358681010755 putative metal-binding site [ion binding]; other site 358681010756 nucleotide binding site [chemical binding]; other site 358681010757 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186 358681010758 domain I; other site 358681010759 DNA binding groove [nucleotide binding] 358681010760 phosphate binding site [ion binding]; other site 358681010761 domain II; other site 358681010762 domain III; other site 358681010763 nucleotide binding site [chemical binding]; other site 358681010764 catalytic site [active] 358681010765 domain IV; other site 358681010766 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 358681010767 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 358681010768 RNA polymerases M/15 Kd subunit; Region: RNA_POL_M_15KD; cl02717 358681010769 DNA protecting protein DprA; Region: dprA; TIGR00732 358681010770 DNA recombination-mediator protein A; Region: DNA_processg_A; pfam02481 358681010771 succinyl-CoA synthetase subunit alpha; Validated; Region: PRK05678 358681010772 CoA binding domain; Region: CoA_binding; smart00881 358681010773 CoA-ligase; Region: Ligase_CoA; pfam00549 358681010774 succinyl-CoA synthetase subunit beta; Provisional; Region: sucC; PRK00696 358681010775 ATP-grasp domain; Region: ATP-grasp_2; pfam08442 358681010776 CoA-ligase; Region: Ligase_CoA; pfam00549 358681010777 Divergent AAA domain; Region: AAA_4; pfam04326 358681010778 SCP-2 sterol transfer family; Region: SCP2; pfam02036 358681010779 Putative heavy-metal-binding; Region: YbjQ_1; cl00426 358681010780 FOG: CBS domain [General function prediction only]; Region: COG0517 358681010781 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354 358681010782 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 358681010783 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 358681010784 metal binding site [ion binding]; metal-binding site 358681010785 active site 358681010786 I-site; other site 358681010787 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 358681010788 Chagasin family peptidase inhibitor I42; Region: Inhibitor_I42; pfam09394 358681010789 Predicted ATPase with chaperone activity [Posttranslational modification, protein turnover, chaperones]; Region: COG0606 358681010790 Magnesium chelatase, subunit ChlI; Region: Mg_chelatase; pfam01078 358681010791 Magnesium chelatase, subunit ChlI; Region: Mg_chelatase_2; pfam13335 358681010792 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 358681010793 non-specific DNA binding site [nucleotide binding]; other site 358681010794 salt bridge; other site 358681010795 sequence-specific DNA binding site [nucleotide binding]; other site 358681010796 Staphylococcal nuclease homologues; Region: SNc; smart00318 358681010797 Staphylococcal nuclease homologues. SNase homologues are found in bacteria, archaea, and eukaryotes. They contain no disufide bonds; Region: SNc; cd00175 358681010798 Catalytic site; other site 358681010799 Excalibur calcium-binding domain; Region: Excalibur; smart00894 358681010800 Restriction endonuclease; Region: Mrr_cat; pfam04471 358681010801 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 358681010802 Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583 358681010803 amidase catalytic site [active] 358681010804 Zn binding residues [ion binding]; other site 358681010805 substrate binding site [chemical binding]; other site 358681010806 Copper amine oxidase N-terminal domain; Region: Cu_amine_oxidN1; pfam07833 358681010807 Holin family; Region: Phage_holin_4; cl01989 358681010808 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes; Region: PLPDE_III; cl00261 358681010809 Baseplate J-like protein; Region: Baseplate_J; pfam04865 358681010810 Protein of unknown function (DUF2634); Region: DUF2634; pfam10934 358681010811 Protein of unknown function (DUF2577); Region: DUF2577; pfam10844 358681010812 Phage-related minor tail protein; Region: PhageMin_Tail; pfam10145 358681010813 Protein of unknown function (DUF2001); Region: DUF2001; pfam09393 358681010814 Phage tail sheath protein; Region: Phage_sheath_1; pfam04984 358681010815 Head-Tail Connector Proteins gp6 and gp15, and similar proteins; Region: gp6_gp15_like; cl12049 358681010816 Phage capsid family; Region: Phage_capsid; pfam05065 358681010817 Protein of unknown function (DUF464); Region: DUF464; pfam04327 358681010818 Phage Mu protein F like protein; Region: Phage_Mu_F; cl10072 358681010819 phage portal protein, SPP1 family; Region: portal_SPP1; TIGR01538 358681010820 Phage portal protein, SPP1 Gp6-like; Region: Phage_prot_Gp6; pfam05133 358681010821 Terminase-like family; Region: Terminase_6; pfam03237 358681010822 Phage terminase large subunit; Region: Terminase_3; cl12054 358681010823 Uncharacterized conserved protein [Function unknown]; Region: COG5484 358681010824 Domain of unknown function (DUF4145); Region: DUF4145; pfam13643 358681010825 Stage 0 sporulation protein J (antagonist of Soj) containing ParB-like nuclease domain [Transcription]; Region: Spo0J; COG1475 358681010826 ParB-like nuclease domain; Region: ParB; smart00470 358681010827 DNA modification methylase [DNA replication, recombination, and repair]; Region: COG0863 358681010828 DNA methylase; Region: N6_N4_Mtase; pfam01555 358681010829 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 358681010830 signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227 358681010831 Catalytic site [active] 358681010832 flagellar hook-basal body protein; Region: FlgEFG_subfam; TIGR03506 358681010833 ASC-1 homology domain, ASC-1-like subfamily. The ASCH domain, a small beta-barrel domain found in all three kingdoms of life, resembles the RNA-binding PUA domain and may also interact with RNA. ASCH has been proposed to function as an RNA-binding domain...; Region: ASCH_ASC-1_like; cd06554 358681010834 Site-specific DNA methylase [DNA replication, recombination, and repair]; Region: Dam; COG0338 358681010835 Domain of unknown function (DUF3578); Region: DUF3578; pfam12102 358681010836 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 358681010837 active site 358681010838 Replication initiation and membrane attachment; Region: DnaB_2; pfam07261 358681010839 HNH endonuclease; Region: HNH; pfam01844 358681010840 active site 358681010841 RecT family; Region: RecT; cl04285 358681010842 YqaJ-like viral recombinase domain; Region: YqaJ; cl09232 358681010843 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 358681010844 non-specific DNA binding site [nucleotide binding]; other site 358681010845 salt bridge; other site 358681010846 sequence-specific DNA binding site [nucleotide binding]; other site 358681010847 Restriction endonuclease; Region: Mrr_cat; pfam04471 358681010848 SIR2 superfamily of proteins includes silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein/histone deacetylation, where the acetyl group from the lysine epsilon-amino group is transferred to the ADP-ribose moiety of NAD+; Region: SIR2; cl00195 358681010849 SIR2-like domain; Region: SIR2_2; pfam13289 358681010850 AAA ATPase domain; Region: AAA_16; pfam13191 358681010851 NB-ARC domain; Region: NB-ARC; pfam00931 358681010852 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 358681010853 binding surface 358681010854 TPR motif; other site 358681010855 Tetratricopeptide repeat; Region: TPR_12; pfam13424 358681010856 Tetratricopeptide repeat; Region: TPR_12; pfam13424 358681010857 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 358681010858 binding surface 358681010859 TPR motif; other site 358681010860 Tetratricopeptide repeat; Region: TPR_12; pfam13424 358681010861 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 358681010862 binding surface 358681010863 TPR motif; other site 358681010864 Tetratricopeptide repeat; Region: TPR_12; pfam13424 358681010865 Domain of unknown function (DUF955); Region: DUF955; pfam06114 358681010866 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961 358681010867 Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cd00338 358681010868 catalytic residues [active] 358681010869 catalytic nucleophile [active] 358681010870 Recombinase; Region: Recombinase; pfam07508 358681010871 Recombinase zinc beta ribbon domain; Region: Zn_ribbon_recom; pfam13408 358681010872 Predicted ATPase with chaperone activity [Posttranslational modification, protein turnover, chaperones]; Region: COG0606 358681010873 Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541 358681010874 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 358681010875 Walker A motif; other site 358681010876 ATP binding site [chemical binding]; other site 358681010877 Walker B motif; other site 358681010878 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 358681010879 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 358681010880 non-specific DNA binding site [nucleotide binding]; other site 358681010881 salt bridge; other site 358681010882 sequence-specific DNA binding site [nucleotide binding]; other site 358681010883 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 358681010884 AAA domain; Region: AAA_21; pfam13304 358681010885 Walker A/P-loop; other site 358681010886 ATP binding site [chemical binding]; other site 358681010887 AAA domain; Region: AAA_21; pfam13304 358681010888 Predicted NTPase (NACHT family) [Signal transduction mechanisms]; Region: COG5635 358681010889 Protein of unknown function (DUF2716); Region: DUF2716; pfam10898 358681010890 Domain of unknown function (DUF955); Region: DUF955; pfam06114 358681010891 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961 358681010892 Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cd00338 358681010893 catalytic residues [active] 358681010894 catalytic nucleophile [active] 358681010895 Recombinase; Region: Recombinase; pfam07508 358681010896 Recombinase zinc beta ribbon domain; Region: Zn_ribbon_recom; pfam13408 358681010897 RNA:NAD 2'-phosphotransferase [Translation, ribosomal structure and biogenesis]; Region: KptA; COG1859 358681010898 RNA 2'-phosphotransferase; Reviewed; Region: PRK00819 358681010899 Low molecular weight phosphatase family; Region: LMWPc; cl00105 358681010900 active site 358681010901 Domain of unknown function (DUF1768); Region: DUF1768; cl01271 358681010902 Predicted nucleotidyltransferase; Region: Nuc-transf; pfam10127 358681010903 Bacterial surface proteins containing Ig-like domains [Cell motility and secretion]; Region: COG5492 358681010904 Bacterial Ig-like domain (group 2); Region: Big_2; cl02708 358681010905 hypothetical protein; Reviewed; Region: PRK12497 358681010906 Uncharacterized homolog of the cytoplasmic domain of flagellar protein FhlB [Function unknown]; Region: COG2257 358681010907 bacterial Ribonuclease HII-like; Region: RNase_HII_bacteria_HII_like; cd07182 358681010908 RNA/DNA hybrid binding site [nucleotide binding]; other site 358681010909 active site 358681010910 GTPase YlqF; Reviewed; Region: rbgA; PRK09563 358681010911 Circularly permuted YlqF GTPase; Region: YlqF; cd01856 358681010912 GTP/Mg2+ binding site [chemical binding]; other site 358681010913 G4 box; other site 358681010914 G5 box; other site 358681010915 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170 358681010916 G1 box; other site 358681010917 G1 box; other site 358681010918 GTP/Mg2+ binding site [chemical binding]; other site 358681010919 Switch I region; other site 358681010920 G2 box; other site 358681010921 G2 box; other site 358681010922 Switch I region; other site 358681010923 G3 box; other site 358681010924 G3 box; other site 358681010925 Switch II region; other site 358681010926 Switch II region; other site 358681010927 signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227 358681010928 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 358681010929 Catalytic site [active] 358681010930 50S ribosomal protein L19; Provisional; Region: rplS; PRK05338 358681010931 tRNA (guanine-N(1)-)-methyltransferase; Reviewed; Region: trmD; PRK00026 358681010932 16S rRNA-processing protein RimM; Provisional; Region: rimM; PRK00122 358681010933 RimM N-terminal domain; Region: RimM; pfam01782 358681010934 PRC-barrel domain; Region: PRC; pfam05239 358681010935 Protein of unknown function (DUF2869); Region: DUF2869; pfam11068 358681010936 Predicted RNA-binding protein (contains KH domain) [General function prediction only]; Region: COG1837 358681010937 hypothetical protein; Provisional; Region: PRK00468 358681010938 G-X-X-G motif; other site 358681010939 30S ribosomal protein S16; Reviewed; Region: rpsP; PRK00040 358681010940 signal recognition particle protein; Provisional; Region: PRK10867 358681010941 SRP54-type protein, helical bundle domain; Region: SRP54_N; smart00963 358681010942 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115 358681010943 P loop; other site 358681010944 GTP binding site [chemical binding]; other site 358681010945 Signal peptide binding domain; Region: SRP_SPB; pfam02978 358681010946 putative DNA-binding protein; Validated; Region: PRK00118 358681010947 Putative helix-turn-helix protein, YlxM / p13 like; Region: UPF0122; pfam04297 358681010948 signal recognition particle-docking protein FtsY; Provisional; Region: PRK10416 358681010949 SRP54-type protein, helical bundle domain; Region: SRP54_N; pfam02881 358681010950 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115 358681010951 P loop; other site 358681010952 GTP binding site [chemical binding]; other site 358681010953 chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168 358681010954 ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278 358681010955 Walker A/P-loop; other site 358681010956 ATP binding site [chemical binding]; other site 358681010957 Q-loop/lid; other site 358681010958 SMC proteins Flexible Hinge Domain; Region: SMC_hinge; smart00968 358681010959 ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278 358681010960 Q-loop/lid; other site 358681010961 ABC transporter signature motif; other site 358681010962 Walker B; other site 358681010963 D-loop; other site 358681010964 H-loop/switch region; other site 358681010965 ribonuclease III; Reviewed; Region: rnc; PRK00102 358681010966 RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in...; Region: RIBOc; cd00593 358681010967 dimerization interface [polypeptide binding]; other site 358681010968 active site 358681010969 metal binding site [ion binding]; metal-binding site 358681010970 Double-stranded RNA binding motif. Binding is not sequence specific but is highly specific for double stranded RNA. Found in a variety of proteins including dsRNA dependent protein kinase PKR, RNA helicases, Drosophila staufen protein, E. coli RNase III; Region: DSRM; cd00048 358681010971 beta-ketoacyl-acyl-carrier-protein synthase II; Region: fabF; TIGR03150 358681010972 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 358681010973 dimer interface [polypeptide binding]; other site 358681010974 active site 358681010975 acyl carrier protein; Provisional; Region: acpP; PRK00982 358681010976 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 358681010977 beta-Keto acyl carrier protein reductase (BKR), involved in Type II FAS, classical (c) SDRs; Region: BKR_SDR_c; cd05333 358681010978 NAD(P) binding site [chemical binding]; other site 358681010979 homotetramer interface [polypeptide binding]; other site 358681010980 homodimer interface [polypeptide binding]; other site 358681010981 active site 358681010982 (acyl-carrier-protein) S-malonyltransferase [Lipid metabolism]; Region: FabD; COG0331 358681010983 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 358681010984 3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK09352 358681010985 Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830 358681010986 dimer interface [polypeptide binding]; other site 358681010987 active site 358681010988 CoA binding pocket [chemical binding]; other site 358681010989 putative phosphate acyltransferase; Provisional; Region: PRK05331 358681010990 fatty acid biosynthesis transcriptional regulator; Provisional; Region: PRK04424 358681010991 DeoR-like helix-turn-helix domain; Region: HTH_DeoR; cl17531 358681010992 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cd03440 358681010993 active site 2 [active] 358681010994 active site 1 [active] 358681010995 ABC-type uncharacterized transport system, ATPase component [General function prediction only]; Region: COG4586 358681010996 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 358681010997 Walker A/P-loop; other site 358681010998 ATP binding site [chemical binding]; other site 358681010999 Q-loop/lid; other site 358681011000 ABC transporter signature motif; other site 358681011001 Walker B; other site 358681011002 D-loop; other site 358681011003 H-loop/switch region; other site 358681011004 ABC-2 family transporter protein; Region: ABC2_membrane_6; cl01496 358681011005 ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG4587 358681011006 ABC-2 family transporter protein; Region: ABC2_membrane_6; cl01496 358681011007 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 358681011008 DeoR-like helix-turn-helix domain; Region: HTH_DeoR; pfam08220 358681011009 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 358681011010 50S ribosomal protein L32; Reviewed; Region: rpmF; PRK12286 358681011011 Uncharacterized ACR, COG1399; Region: DUF177; pfam02620 358681011012 Predicted secreted protein containing a PDZ domain [Signal transduction mechanisms]; Region: SdrC; COG3480 358681011013 PDZ domain, also called DHR (Dlg homologous region) or GLGF (after a conserved sequence motif). Many PDZ domains bind C-terminal polypeptides, though binding to internal (non-C-terminal) polypeptides and even to lipids has been demonstrated; Region: PDZ; cl00117 358681011014 protein binding site [polypeptide binding]; other site 358681011015 Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362 358681011016 Predicted esterase of the alpha-beta hydrolase superfamily [General function prediction only]; Region: RssA; COG1752 358681011017 Bacterial patatin-like phospholipase domain containing protein 6; Region: Pat_NTE_like_bacteria; cd07228 358681011018 active site 358681011019 nucleophile elbow; other site 358681011020 sporulation integral membrane protein YlbJ; Region: spore_ylbJ; TIGR02871 358681011021 Nucleoside recognition; Region: Gate; pfam07670 358681011022 phosphopantetheine adenylyltransferase; Provisional; Region: coaD; PRK00168 358681011023 Phosphopantetheine adenylyltransferase; Region: PPAT; cd02163 358681011024 active site 358681011025 (T/H)XGH motif; other site 358681011026 N6-adenine-specific methylase [DNA replication, recombination, and repair]; Region: COG0742 358681011027 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 358681011028 S-adenosylmethionine binding site [chemical binding]; other site 358681011029 Ku protein, prokaryotic; Region: Ku_bact; TIGR02772 358681011030 Ku-core domain, Ku-like subfamily; composed of prokaryotic homologs of the eukaryotic DNA binding protein Ku. The alignment includes the core domain shared by the prokaryotic YkoV-like proteins and the eukaryotic Ku70 and Ku80. The prokaryotic Ku...; Region: KU_like; cd00789 358681011031 putative DNA binding site [nucleotide binding]; other site 358681011032 putative homodimer interface [polypeptide binding]; other site 358681011033 Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053 358681011034 cation diffusion facilitator family transporter; Region: CDF; TIGR01297 358681011035 thiamine biosynthesis protein ThiC; Provisional; Region: PRK09284 358681011036 ThiC-associated domain; Region: ThiC-associated; pfam13667 358681011037 ThiC family; Region: ThiC; pfam01964 358681011038 Domain of unknown function (DUF1904); Region: DUF1904; pfam08921 358681011039 Adenylation domain of Mycobacterium tuberculosis LigD and LigC-like ATP-dependent DNA ligases; Region: Adenylation_DNA_ligase_LigD_LigC; cd07906 358681011040 DNA polymerase LigD, ligase domain; Region: NHEJ_ligase_lig; TIGR02779 358681011041 active site 358681011042 DNA binding site [nucleotide binding] 358681011043 The Oligonucleotide/oligosaccharide binding (OB)-fold domain of ATP-dependent DNA ligase LigD is a DNA-binding module that is part of the catalytic core unit; Region: OBF_DNA_ligase_LigD; cd07971 358681011044 DNA binding site [nucleotide binding] 358681011045 Beta-lactamase; Region: Beta-lactamase; pfam00144 358681011046 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 358681011047 Glycopeptide antibiotics resistance protein [Defense mechanisms]; Region: VanZ; COG4767 358681011048 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 358681011049 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 358681011050 ABC-2 family transporter protein; Region: ABC2_membrane_2; cl17866 358681011051 ABC-2 family transporter protein; Region: ABC2_membrane_4; pfam12730 358681011052 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 358681011053 ATP-binding cassette domain of the bacitracin-resistance transporter; Region: ABC_BcrA_bacitracin_resist; cd03268 358681011054 Walker A/P-loop; other site 358681011055 ATP binding site [chemical binding]; other site 358681011056 Q-loop/lid; other site 358681011057 ABC transporter signature motif; other site 358681011058 Walker B; other site 358681011059 D-loop; other site 358681011060 H-loop/switch region; other site 358681011061 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 358681011062 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 358681011063 dimer interface [polypeptide binding]; other site 358681011064 phosphorylation site [posttranslational modification] 358681011065 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 358681011066 ATP binding site [chemical binding]; other site 358681011067 Mg2+ binding site [ion binding]; other site 358681011068 G-X-G motif; other site 358681011069 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 358681011070 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 358681011071 active site 358681011072 phosphorylation site [posttranslational modification] 358681011073 intermolecular recognition site; other site 358681011074 dimerization interface [polypeptide binding]; other site 358681011075 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 358681011076 DNA binding site [nucleotide binding] 358681011077 Spore germination protein; Region: Spore_permease; cl17796 358681011078 germination protein, Ger(x)C family; Region: spore_ger_x_C; TIGR02887 358681011079 Spore germination B3/ GerAC like, C-terminal; Region: Spore_GerAC; pfam05504 358681011080 Bacillus/Clostridium GerA spore germination protein; Region: GerA; pfam03323 358681011081 AE_Prim_S_like: primase domain similar to that found in the small subunit of archaeal and eukaryotic (A/E) DNA primases. The replication machineries of A/Es are distinct from that of bacteria. Primases are DNA-dependent RNA polymerases which synthesis...; Region: AE_Prim_S_like; cl01287 358681011082 nucleotide binding site [chemical binding]; other site 358681011083 prolipoprotein diacylglyceryl transferase; Reviewed; Region: PRK12437 358681011084 Phosphate/sulphate permeases [Inorganic ion transport and metabolism]; Region: PitA; COG0306 358681011085 Phosphate transport regulator (distant homolog of PhoU) [Inorganic ion transport and metabolism]; Region: COG1392 358681011086 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 358681011087 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 358681011088 metal binding site [ion binding]; metal-binding site 358681011089 active site 358681011090 I-site; other site 358681011091 Predicted naringenin-chalcone synthase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: BcsA; COG3424 358681011092 Chalcone and stilbene synthases; plant-specific polyketide synthases (PKS) and related enzymes, also called type III PKSs. PKS generate an array of different products, dependent on the nature of the starter molecule. They share a common chemical strategy; Region: CHS_like; cd00831 358681011093 malonyl-CoA binding site [chemical binding]; other site 358681011094 dimer interface [polypeptide binding]; other site 358681011095 active site 358681011096 product binding site; other site 358681011097 Phospholipid methyltransferase; Region: PEMT; cl17370 358681011098 Leucyl aminopeptidase (aminopeptidase T) [Amino acid transport and metabolism]; Region: AmpS; COG2309 358681011099 Thermophilic metalloprotease (M29); Region: Peptidase_M29; pfam02073 358681011100 Protein of unknown function (DUF4025); Region: DUF4025; pfam13217 358681011101 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 358681011102 MarR family; Region: MarR; pfam01047 358681011103 signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227 358681011104 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 358681011105 Catalytic site [active] 358681011106 D-alanyl-D-alanine carboxypeptidase [Cell envelope biogenesis, outer membrane]; Region: VanY; COG1876 358681011107 D-alanyl-D-alanine carboxypeptidase; Region: VanY; pfam02557 358681011108 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 358681011109 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 358681011110 NAD(P) binding site [chemical binding]; other site 358681011111 active site 358681011112 Gamma-glutamyltransferase [Amino acid transport and metabolism]; Region: Ggt; COG0405 358681011113 Gamma-glutamyltranspeptidase; Region: G_glu_transpept; pfam01019 358681011114 Predicted periplasmic protein (DUF2233); Region: DUF2233; pfam09992 358681011115 chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168 358681011116 RDD family; Region: RDD; pfam06271 358681011117 Uncharacterized membrane protein [Function unknown]; Region: SpoIIM; COG1300 358681011118 Uncharacterized conserved protein (some members contain a von Willebrand factor type A (vWA) domain) [General function prediction only]; Region: COG1721 358681011119 Protein of unknown function DUF58; Region: DUF58; pfam01882 358681011120 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057 358681011121 metal ion-dependent adhesion site (MIDAS); other site 358681011122 MoxR-like ATPases [General function prediction only]; Region: COG0714 358681011123 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 358681011124 Walker A motif; other site 358681011125 ATP binding site [chemical binding]; other site 358681011126 Walker B motif; other site 358681011127 arginine finger; other site 358681011128 Domain of unknown function (DUF4350); Region: DUF4350; pfam14258 358681011129 Domain of unknown function (DUF4129); Region: DUF4129; pfam13559 358681011130 Membrane domain of glycerophosphoryl diester phosphodiesterase; Region: GPDPase_memb; cl01974 358681011131 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 358681011132 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 358681011133 spore coat protein, CotS family; Region: spore_CotS; TIGR02906 358681011134 spore coat protein YsxE; Region: spore_ysxE; TIGR02904 358681011135 SWIM zinc finger; Region: SWIM; pfam04434 358681011136 Bacterial SNF2 helicase associated; Region: SNF2_assoc; pfam08455 358681011137 SNF2 family N-terminal domain; Region: SNF2_N; pfam00176 358681011138 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 358681011139 ATP binding site [chemical binding]; other site 358681011140 putative Mg++ binding site [ion binding]; other site 358681011141 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 358681011142 nucleotide binding region [chemical binding]; other site 358681011143 ATP-binding site [chemical binding]; other site 358681011144 Catalytic NodB homology domain of Bacillus subtilis polysaccharide deacetylase PdaA, and its bacterial homologs; Region: CE4_BsPdaA_like; cd10948 358681011145 delta-lactam-biosynthetic de-N-acetylase; Region: spore_pdaA; TIGR02884 358681011146 NodB motif; other site 358681011147 active site 358681011148 catalytic site [active] 358681011149 Cd binding site [ion binding]; other site 358681011150 aspartate ammonia-lyase; Provisional; Region: aspA; PRK12273 358681011151 Aspartase; Region: Aspartase; cd01357 358681011152 active sites [active] 358681011153 tetramer interface [polypeptide binding]; other site 358681011154 Immunoglobulin-like domain of bacterial spore germination; Region: Gmad2; pfam10648 358681011155 Integral membrane protein (intg_mem_TP0381); Region: Intg_mem_TP0381; pfam09529 358681011156 Transcriptional regulator [Transcription]; Region: LysR; COG0583 358681011157 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 358681011158 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 358681011159 dimerization interface [polypeptide binding]; other site 358681011160 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 358681011161 EamA-like transporter family; Region: EamA; pfam00892 358681011162 Putative hydrophobic ligand-binding SRPBCC domain of an uncharacterized subgroup of CalC- and Aha1-like proteins; Region: SRPBCC_CalC_Aha1-like_1; cd08894 358681011163 putative hydrophobic ligand binding site [chemical binding]; other site 358681011164 Predicted metal-dependent hydrolase with the TIM-barrel fold [General function prediction only]; Region: COG1574 358681011165 YtcJ_like metal dependent amidohydrolases. YtcJ is a Bacillus subtilis ORF of unknown function. The Arabidopsis homolog LAF3 has been identified as a factor required for photochrome A signalling; Region: YtcJ_like; cd01300 358681011166 active site 358681011167 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 358681011168 Major Facilitator Superfamily; Region: MFS_1; pfam07690 358681011169 putative substrate translocation pore; other site 358681011170 YolD-like protein; Region: YolD; pfam08863 358681011171 DNA polymerase IV; Reviewed; Region: PRK03103 358681011172 umuC subunit of DNA Polymerase V; Region: PolY_Pol_V_umuC; cd01700 358681011173 active site 358681011174 DNA binding site [nucleotide binding] 358681011175 Domain of unknown function (DUF4113); Region: DUF4113; pfam13438 358681011176 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 358681011177 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 358681011178 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3708 358681011179 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 358681011180 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 358681011181 active site 358681011182 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 358681011183 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 358681011184 ATP-dependent DNA helicase RecG; Provisional; Region: PRK10917 358681011185 RecG_wedge_OBF: A subfamily of OB folds corresponding to the OB fold found in the N-terminal (wedge) domain of Escherichia coli RecG. RecG is a branched-DNA-specific helicase, which catalyzes the interconversion of a DNA replication fork to a...; Region: RecG_wedge_OBF; cd04488 358681011186 generic binding surface II; other site 358681011187 ssDNA binding site; other site 358681011188 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 358681011189 ATP binding site [chemical binding]; other site 358681011190 putative Mg++ binding site [ion binding]; other site 358681011191 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 358681011192 nucleotide binding region [chemical binding]; other site 358681011193 ATP-binding site [chemical binding]; other site 358681011194 Serine dehydratase alpha chain; Region: SDH_alpha; cl12120 358681011195 L-serine deaminase [Amino acid transport and metabolism]; Region: SdaA; COG1760 358681011196 L-serine dehydratase, iron-sulfur-dependent, beta subunit; Region: sda_beta; TIGR00719 358681011197 Serine dehydratase beta chain; Region: SDH_beta; pfam03315 358681011198 C-terminal ACT domain of the L-serine dehydratase (LSD), iron-sulfur-dependent, beta subunit; Region: ACT_LSD; cd04903 358681011199 putative L-serine binding site [chemical binding]; other site 358681011200 EDD domain protein, DegV family; Region: DegV; TIGR00762 358681011201 Uncharacterized protein, DegV family COG1307; Region: DegV; pfam02645 358681011202 DAK2 domain fusion protein YloV; Region: YloV; TIGR03599 358681011203 DAK2 domain; Region: Dak2; pfam02734 358681011204 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1302 358681011205 50S ribosomal protein L28; Reviewed; Region: rpmB; PRK00359 358681011206 Stage V sporulation protein family; Region: SpoV; cl15455 358681011207 Thiamine transporter protein (Thia_YuaJ); Region: Thia_YuaJ; pfam09515 358681011208 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 358681011209 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 358681011210 Walker A/P-loop; other site 358681011211 ATP binding site [chemical binding]; other site 358681011212 Q-loop/lid; other site 358681011213 ABC transporter signature motif; other site 358681011214 Walker B; other site 358681011215 D-loop; other site 358681011216 H-loop/switch region; other site 358681011217 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 358681011218 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 358681011219 dimer interface [polypeptide binding]; other site 358681011220 conserved gate region; other site 358681011221 putative PBP binding loops; other site 358681011222 ABC-ATPase subunit interface; other site 358681011223 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 358681011224 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 358681011225 substrate binding pocket [chemical binding]; other site 358681011226 membrane-bound complex binding site; other site 358681011227 hinge residues; other site 358681011228 glutamate carboxypeptidase; Reviewed; Region: PRK06133 358681011229 M20 Peptidase Glutamate carboxypeptidase, a periplasmic enzyme; Region: M20_CPDG2; cd03885 358681011230 metal binding site [ion binding]; metal-binding site 358681011231 dimer interface [polypeptide binding]; other site 358681011232 RDD family; Region: RDD; pfam06271 358681011233 PrcB C-terminal; Region: PrcB_C; pfam14343 358681011234 Pentose-5-phosphate-3-epimerase [Carbohydrate transport and metabolism]; Region: Rpe; COG0036 358681011235 Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose...; Region: RPE; cd00429 358681011236 substrate binding site [chemical binding]; other site 358681011237 hexamer interface [polypeptide binding]; other site 358681011238 metal binding site [ion binding]; metal-binding site 358681011239 GTPase RsgA; Reviewed; Region: PRK00098 358681011240 S1_YloQ_GTPase: YloQ GTase family (also known as YjeQ and CpgA), S1-like RNA-binding domain. Proteins in the YloQ GTase family bind the ribosome and have GTPase activity. The precise role of this family is unknown. The protein structure is composed of...; Region: S1_YloQ_GTPase; cd04466 358681011241 RNA binding site [nucleotide binding]; other site 358681011242 homodimer interface [polypeptide binding]; other site 358681011243 Ribosomal interacting GTPase YjeQ/EngC, a circularly permuted subfamily of the Ras GTPases; Region: YjeQ_EngC; cd01854 358681011244 GTPase/Zn-binding domain interface [polypeptide binding]; other site 358681011245 GTP/Mg2+ binding site [chemical binding]; other site 358681011246 G4 box; other site 358681011247 G5 box; other site 358681011248 G1 box; other site 358681011249 Switch I region; other site 358681011250 G2 box; other site 358681011251 G3 box; other site 358681011252 Switch II region; other site 358681011253 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 358681011254 Catalytic domain of Protein Kinases; Region: PKc; cd00180 358681011255 active site 358681011256 ATP binding site [chemical binding]; other site 358681011257 substrate binding site [chemical binding]; other site 358681011258 activation loop (A-loop); other site 358681011259 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2815 358681011260 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 358681011261 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 358681011262 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 358681011263 Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cd00143 358681011264 Protein phosphatase 2C; Region: PP2C; pfam00481 358681011265 active site 358681011266 ribosomal RNA large subunit methyltransferase N; Provisional; Region: PRK14455 358681011267 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 358681011268 FeS/SAM binding site; other site 358681011269 16S rRNA methyltransferase B; Provisional; Region: PRK14902 358681011270 NusB family; Region: NusB; pfam01029 358681011271 putative RNA binding site [nucleotide binding]; other site 358681011272 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 358681011273 S-adenosylmethionine binding site [chemical binding]; other site 358681011274 methionyl-tRNA formyltransferase; Reviewed; Region: fmt; PRK00005 358681011275 Methionyl-tRNA formyltransferase, N-terminal hydrolase domain; Region: FMT_core_Met-tRNA-FMT_N; cd08646 358681011276 putative active site [active] 358681011277 substrate binding site [chemical binding]; other site 358681011278 putative cosubstrate binding site; other site 358681011279 catalytic site [active] 358681011280 C-terminal domain of Formyltransferase and other enzymes; Region: Met_tRNA_FMT_C; cd08704 358681011281 substrate binding site [chemical binding]; other site 358681011282 Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487 358681011283 active site 358681011284 catalytic residues [active] 358681011285 metal binding site [ion binding]; metal-binding site 358681011286 Primosomal protein N' (replication factor Y) - superfamily II helicase [DNA replication, recombination, and repair]; Region: PriA; COG1198 358681011287 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 358681011288 ATP binding site [chemical binding]; other site 358681011289 putative Mg++ binding site [ion binding]; other site 358681011290 nucleotide binding region [chemical binding]; other site 358681011291 helicase superfamily c-terminal domain; Region: HELICc; smart00490 358681011292 ATP-binding site [chemical binding]; other site 358681011293 bifunctional phosphopantothenoylcysteine decarboxylase/phosphopantothenate synthase; Validated; Region: PRK05579 358681011294 Flavoprotein; Region: Flavoprotein; pfam02441 358681011295 DNA / pantothenate metabolism flavoprotein; Region: DFP; pfam04127 358681011296 DNA-directed RNA polymerase subunit omega; Reviewed; Region: rpoZ; PRK00392 358681011297 Guanylate kinase [Nucleotide transport and metabolism]; Region: Gmk; COG0194 358681011298 Guanosine monophosphate kinase (GMPK, EC 2.7.4.8), also known as guanylate kinase (GKase), catalyzes the reversible phosphoryl transfer from adenosine triphosphate (ATP) to guanosine monophosphate (GMP) to yield adenosine diphosphate (ADP) and guanosine...; Region: GMPK; cd00071 358681011299 catalytic site [active] 358681011300 G-X2-G-X-G-K; other site 358681011301 hypothetical protein; Provisional; Region: PRK04323 358681011302 hypothetical protein; Provisional; Region: PRK11820 358681011303 YicC-like family, N-terminal region; Region: YicC_N; pfam03755 358681011304 Domain of unknown function (DUF1732); Region: DUF1732; pfam08340 358681011305 Fibronectin-binding protein A N-terminus (FbpA); Region: FbpA; pfam05833 358681011306 Domain of unknown function (DUF814); Region: DUF814; pfam05670 358681011307 Protein of unknown function (DUF2512); Region: DUF2512; pfam10710 358681011308 enoyl-CoA hydratase; Provisional; Region: PRK06688 358681011309 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 358681011310 substrate binding site [chemical binding]; other site 358681011311 oxyanion hole (OAH) forming residues; other site 358681011312 trimer interface [polypeptide binding]; other site 358681011313 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 358681011314 CoA-transferase family III; Region: CoA_transf_3; pfam02515 358681011315 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3296 358681011316 YjzC-like protein; Region: YjzC; pfam14168 358681011317 Domain of unknown function (DUF309); Region: DUF309; pfam03745 358681011318 RNA:NAD 2'-phosphotransferase [Translation, ribosomal structure and biogenesis]; Region: KptA; COG1859 358681011319 RNA 2'-phosphotransferase; Reviewed; Region: PRK00819 358681011320 CAAX protease self-immunity; Region: Abi; pfam02517 358681011321 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 358681011322 H+ Antiporter protein; Region: 2A0121; TIGR00900 358681011323 putative substrate translocation pore; other site 358681011324 Protein of unknown function (DUF1453); Region: DUF1453; pfam07301 358681011325 RT_G2_intron: Reverse transcriptases (RTs) with group II intron origin. RT transcribes DNA using RNA as template. Proteins in this subfamily are found in bacterial and mitochondrial group II introns. Their most probable ancestor was a retrotransposable...; Region: RT_G2_intron; cd01651 358681011326 Reverse transcriptase (RNA-dependent DNA polymerase); Region: RVT_1; pfam00078 358681011327 putative active site [active] 358681011328 putative NTP binding site [chemical binding]; other site 358681011329 putative nucleic acid binding site [nucleotide binding]; other site 358681011330 Group II intron, maturase-specific domain; Region: GIIM; pfam08388 358681011331 Arsenite efflux pump ACR3 and related permeases [Inorganic ion transport and metabolism]; Region: ACR3; COG0798 358681011332 Sodium Bile acid symporter family; Region: SBF; cl17470 358681011333 Glyoxalase-like domain; Region: Glyoxalase_3; pfam13468 358681011334 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 358681011335 CapA and related proteins, metallophosphatase domain; Region: MPP_CapA; cd07381 358681011336 Bacterial capsule synthesis protein PGA_cap; Region: PGA_cap; smart00854 358681011337 putative active site [active] 358681011338 putative metal binding site [ion binding]; other site 358681011339 Homoserine dehydrogenase [Amino acid transport and metabolism]; Region: ThrA; COG0460 358681011340 Homoserine dehydrogenase, NAD binding domain; Region: NAD_binding_3; pfam03447 358681011341 Homoserine dehydrogenase; Region: Homoserine_dh; pfam00742 358681011342 Mycothiol maleylpyruvate isomerase N-terminal domain; Region: MDMPI_N; pfam11716 358681011343 DinB superfamily; Region: DinB_2; pfam12867 358681011344 Kynurenine formamidase [Amino acid transport and metabolism]; Region: COG1878 358681011345 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 358681011346 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 358681011347 glucose-6-phosphate 1-dehydrogenase; Validated; Region: PRK05722 358681011348 Glucose-6-phosphate dehydrogenase, NAD binding domain; Region: G6PD_N; pfam00479 358681011349 Glucose-6-phosphate dehydrogenase, C-terminal domain; Region: G6PD_C; pfam02781 358681011350 Putative cyclase; Region: Cyclase; cl00814 358681011351 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 358681011352 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 358681011353 Walker A motif; other site 358681011354 ATP binding site [chemical binding]; other site 358681011355 Walker B motif; other site 358681011356 arginine finger; other site 358681011357 Microcystin-dependent protein [Function unknown]; Region: MdpB; COG4675 358681011358 Phage Tail Collar Domain; Region: Collar; pfam07484 358681011359 Microcystin-dependent protein [Function unknown]; Region: MdpB; COG4675 358681011360 Phage Tail Collar Domain; Region: Collar; pfam07484 358681011361 Microcystin-dependent protein [Function unknown]; Region: MdpB; COG4675 358681011362 Phage Tail Collar Domain; Region: Collar; pfam07484 358681011363 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 358681011364 Coenzyme A binding pocket [chemical binding]; other site 358681011365 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 358681011366 dimerization interface [polypeptide binding]; other site 358681011367 putative DNA binding site [nucleotide binding]; other site 358681011368 putative Zn2+ binding site [ion binding]; other site 358681011369 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 358681011370 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 358681011371 active site 358681011372 Orotidine 5'-phosphate decarboxylase (ODCase) is a dimeric enzyme that decarboxylates orotidine 5'-monophosphate (OMP) to form uridine 5'-phosphate (UMP), an essential step in the pyrimidine biosynthetic pathway. In mammals, UMP synthase...; Region: OMP_decarboxylase_like; cd04725 358681011373 active site 358681011374 dimer interface [polypeptide binding]; other site 358681011375 carbamoyl phosphate synthase large subunit; Reviewed; Region: carB; PRK05294 358681011376 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 358681011377 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786 358681011378 Carbamoyl-phosphate synthetase large chain, oligomerisation domain; Region: CPSase_L_D3; pfam02787 358681011379 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 358681011380 ATP-grasp domain; Region: ATP-grasp_4; cl17255 358681011381 Methylglyoxal synthase-like domain from type II glutamine-dependent carbamoyl phosphate synthetase (CSP). CSP, a CarA and CarB heterodimer, catalyzes the production of carbamoyl phosphate which is subsequently employed in the metabolic pathways...; Region: MGS_CPS_II; cd01424 358681011382 IMP binding site; other site 358681011383 dimer interface [polypeptide binding]; other site 358681011384 interdomain contacts; other site 358681011385 partial ornithine binding site; other site 358681011386 carbamoyl phosphate synthase small subunit; Reviewed; Region: PRK12564 358681011387 Carbamoyl-phosphate synthase small chain, CPSase domain; Region: CPSase_sm_chain; smart01097 358681011388 Small chain of the glutamine-dependent form of carbamoyl phosphate synthase, CPSase II; Region: GATase1_CPSase; cd01744 358681011389 catalytic site [active] 358681011390 subunit interface [polypeptide binding]; other site 358681011391 dihydroorotase; Validated; Region: pyrC; PRK09357 358681011392 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 358681011393 Dihydroorotase (DHOase), subgroup IIa; DHOases catalyze the reversible interconversion of carbamoyl aspartate to dihydroorotate, a key reaction in pyrimidine biosynthesis. This subgroup also contains proteins that lack the active site, like unc-33, a C; Region: DHOase_IIa; cd01317 358681011394 active site 358681011395 aspartate carbamoyltransferase catalytic subunit; Provisional; Region: pyrB; PRK00856 358681011396 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 358681011397 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 358681011398 uracil transporter; Provisional; Region: PRK10720 358681011399 Pyrimidine operon attenuation protein/uracil phosphoribosyltransferase [Nucleotide transport and metabolism]; Region: PyrR; COG2065 358681011400 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 358681011401 active site 358681011402 Periplasmic component of the Tol biopolymer transport system [Intracellular trafficking and secretion]; Region: TolB; COG0823 358681011403 translocation protein TolB; Provisional; Region: tolB; PRK02889 358681011404 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 358681011405 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_16; cd07263 358681011406 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 358681011407 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 358681011408 RNA binding surface [nucleotide binding]; other site 358681011409 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 358681011410 active site 358681011411 lipoprotein signal peptidase; Reviewed; Region: lspA; PRK00376 358681011412 lipoprotein signal peptidase; Provisional; Region: PRK14787 358681011413 Serine/threonine protein kinase [General function prediction only / Signal transduction mechanisms / Transcription / DNA replication, recombination, and repair]; Region: SPS1; COG0515 358681011414 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270 358681011415 active site 358681011416 ATP binding site [chemical binding]; other site 358681011417 This PGM-like (phosphoglucomutase-like) protein of unknown function belongs to the alpha-D-phosphohexomutase superfamily and is found in both archaea and bacteria. The alpha-D-phosphohexomutases include several related enzymes that catalyze a reversible...; Region: PGM_like2; cd05800 358681011418 Phosphomannomutase [Carbohydrate transport and metabolism]; Region: {ManB}; COG1109 358681011419 active site 358681011420 substrate binding site [chemical binding]; other site 358681011421 metal binding site [ion binding]; metal-binding site 358681011422 Glucoamylase and related glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: SGA1; COG3387 358681011423 Glycosyl hydrolases family 15; Region: Glyco_hydro_15; pfam00723 358681011424 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis/translation initiation factor 2B, gamma/epsilon subunits (eIF-2Bgamma/eIF-2Bepsilon) [Cell envelope biogenesis, outer membrane / Translation, ribosomal structure...; Region: GCD1; COG1208 358681011425 NTP_transferases catalyze the transfer of nucleotides onto phosphosugars; Region: NTP_transferase; cd04181 358681011426 active site 358681011427 Substrate binding site; other site 358681011428 Mg++ binding site; other site 358681011429 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 358681011430 putative trimer interface [polypeptide binding]; other site 358681011431 putative CoA binding site [chemical binding]; other site 358681011432 phosphoglucosamine mutase; Region: Arch_GlmM; TIGR03990 358681011433 The alpha-D-phosphohexomutase superfamily includes several related enzymes that catalyze a reversible intramolecular phosphoryl transfer on their sugar substrates. Members of this family include the phosphoglucomutases (PGM1 and PGM2), phosphoglucosamine...; Region: phosphohexomutase; cl03757 358681011434 active site 358681011435 substrate binding site [chemical binding]; other site 358681011436 metal binding site [ion binding]; metal-binding site 358681011437 Uncharacterized conserved protein [Function unknown]; Region: COG1543 358681011438 N-terminal catalytic domain of alpha-amylase ( AmyC ) and similar proteins; Region: GH57N_AmyC_like; cd10792 358681011439 active site 358681011440 substrate binding site [chemical binding]; other site 358681011441 catalytic site [active] 358681011442 Domain of unknown function (DUF1957); Region: DUF1957; pfam09210 358681011443 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 358681011444 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 358681011445 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3330 358681011446 Peptidase family M9 N-terminal; Region: Peptidase_M9_N; pfam08453 358681011447 Peptidase Gluzincin family (thermolysin-like proteinases, TLPs) includes peptidases M1, M2, M3, M4, M13, M32 and M36 (fungalysins); Region: GluZincin; cl14813 358681011448 Bacterial pre-peptidase C-terminal domain; Region: PPC; pfam04151 358681011449 Domain of unknown function (DUF4247); Region: DUF4247; pfam14042 358681011450 Domain of unknown function (DUF4178); Region: DUF4178; pfam13785 358681011451 Predicted membrane protein [Function unknown]; Region: COG3766 358681011452 Phage shock protein A (IM30), suppresses sigma54-dependent transcription [Transcription / Signal transduction mechanisms]; Region: PspA; COG1842 358681011453 Major Facilitator Superfamily; Region: MFS_1; pfam07690 358681011454 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 358681011455 putative substrate translocation pore; other site 358681011456 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 358681011457 Coenzyme A binding pocket [chemical binding]; other site 358681011458 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 358681011459 Metal-dependent hydrolases of the beta-lactamase superfamily II [General function prediction only]; Region: COG1237 358681011460 Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491 358681011461 Predicted transcriptional regulators [Transcription]; Region: COG1733 358681011462 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 358681011463 DNA topoisomerase III; Provisional; Region: PRK07726 358681011464 TOPRIM_TopoIA_TopoIII: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to topoisomerase III. Type IA DNA topoisomerases remove (relax) negative supercoils in the DNA by: cleaving...; Region: TOPRIM_TopoIA_TopoIII; cd03362 358681011465 active site 358681011466 putative interdomain interaction site [polypeptide binding]; other site 358681011467 putative metal-binding site [ion binding]; other site 358681011468 putative nucleotide binding site [chemical binding]; other site 358681011469 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186 358681011470 domain I; other site 358681011471 DNA binding groove [nucleotide binding] 358681011472 phosphate binding site [ion binding]; other site 358681011473 domain II; other site 358681011474 domain III; other site 358681011475 nucleotide binding site [chemical binding]; other site 358681011476 catalytic site [active] 358681011477 domain IV; other site 358681011478 C-terminal repeat of topoisomerase; Region: Toprim_Crpt; pfam13342 358681011479 Protein of unknown function (DUF2515); Region: DUF2515; pfam10720 358681011480 squalene-hopene cyclase; Region: hopene_cyclase; TIGR01507 358681011481 This group contains class II terpene cyclases, protein prenyltransferases beta subunit, two broadly specific proteinase inhibitors alpha2-macroglobulin (alpha (2)-M) and pregnancy zone protein (PZP) and, the C3 C4 and C5 components of vertebrate...; Region: ISOPREN_C2_like; cl08267 358681011482 Spore germination protein gerPA/gerPF; Region: gerPA; pfam10676 358681011483 Protein of unknown function (DUF2539); Region: DUF2539; pfam10803 358681011484 Spore germination protein GerPC; Region: GerPC; pfam10737 358681011485 Protein of unknown function (DUF2772); Region: DUF2772; pfam10970 358681011486 Spore germination protein gerPA/gerPF; Region: gerPA; pfam10676 358681011487 phosphoenolpyruvate synthase; Validated; Region: PRK06241 358681011488 Pyruvate phosphate dikinase, PEP/pyruvate binding domain; Region: PPDK_N; pfam01326 358681011489 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 358681011490 Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071 358681011491 Alpha-crystallin domain (ACD) of alpha-crystallin-type small(s) heat shock proteins (Hsps). sHsps are small stress induced proteins with monomeric masses between 12 -43 kDa, whose common feature is the Alpha-crystallin domain (ACD). sHsps are generally...; Region: ACD_sHsps-like; cd06464 358681011492 putative dimer interface [polypeptide binding]; other site 358681011493 Cell envelope-related transcriptional attenuator domain; Region: LytR_cpsA_psr; pfam03816 358681011494 Thioredoxin reductase [Posttranslational modification, protein turnover, chaperones]; Region: TrxB; COG0492 358681011495 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 358681011496 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 358681011497 nucleoside triphosphatase YtkD; Region: nudix_YtkD; TIGR02705 358681011498 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_8; cd04665 358681011499 nudix motif; other site 358681011500 Major Facilitator Superfamily; Region: MFS_1; pfam07690 358681011501 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 358681011502 putative substrate translocation pore; other site 358681011503 L-alanine-DL-glutamate epimerase and related enzymes of enolase superfamily [Cell envelope biogenesis, outer membrane / General function prediction only]; Region: COG4948 358681011504 Mandelate racemase (MR)-like subfamily of the enolase superfamily. Enzymes of this subgroup share three conserved carboxylate ligands for the essential divalent metal ion (usually Mg2+), two aspartates and a glutamate, and conserved catalytic residues; Region: MR_like; cd03316 358681011505 active site pocket [active] 358681011506 Prokaryotic dksA/traR C4-type zinc finger; Region: zf-dskA_traR; cl00755 358681011507 isoleucyl-tRNA synthetase; Reviewed; Region: ileS; PRK05743 358681011508 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 358681011509 active site 358681011510 HIGH motif; other site 358681011511 nucleotide binding site [chemical binding]; other site 358681011512 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 358681011513 catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818 358681011514 active site 358681011515 KMSKS motif; other site 358681011516 Anticodon-binding domain of bacterial and eukaryotic mitochondrial isoleucyl tRNA synthetases; Region: Anticodon_Ia_Ile_BEm; cd07960 358681011517 tRNA binding surface [nucleotide binding]; other site 358681011518 anticodon binding site; other site 358681011519 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 358681011520 DivIVA protein; Region: DivIVA; pfam05103 358681011521 DivIVA domain; Region: DivI1A_domain; TIGR03544 358681011522 ATP synthase B/B' CF(0); Region: ATP-synt_B; cl17192 358681011523 Uncharacterized conserved protein, contains S4-like domain [Function unknown]; Region: COG2302 358681011524 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 358681011525 RNA binding surface [nucleotide binding]; other site 358681011526 YGGT family; Region: YGGT; pfam02325 358681011527 Protein of unknown function (DUF552); Region: DUF552; pfam04472 358681011528 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes, YBL036c-like proteins; Region: PLPDE_III_YBL036c_like; cd00635 358681011529 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 358681011530 catalytic residue [active] 358681011531 Multicopper polyphenol oxidase (laccase) [Secondary metabolites biosynthesis, transport and catabolism]; Region: yfiH; COG1496 358681011532 Multi-copper polyphenol oxidoreductase laccase; Region: Cu-oxidase_4; pfam02578 358681011533 sporulation protein, YlmC/YmxH family; Region: spore_YlmC_YmxH; TIGR02888 358681011534 sporulation sigma factor SigG; Reviewed; Region: PRK08215 358681011535 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 358681011536 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 358681011537 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 358681011538 DNA binding residues [nucleotide binding] 358681011539 sporulation sigma factor SigE; Reviewed; Region: PRK08301 358681011540 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 358681011541 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 358681011542 DNA binding residues [nucleotide binding] 358681011543 Sporulation factor SpoIIGA; Region: Peptidase_U4; pfam03419 358681011544 sigma-E processing peptidase SpoIIGA; Region: spore_II_GA; TIGR02854 358681011545 cell division protein FtsZ; Validated; Region: PRK09330 358681011546 FtsZ is a GTPase that is similar to the eukaryotic tubulins and is essential for cell division in prokaryotes. FtsZ is capable of polymerizing in a GTP-driven process into structures similar to those formed by tubulin. FtsZ forms a ring-shaped septum at...; Region: FtsZ_type1; cd02201 358681011547 nucleotide binding site [chemical binding]; other site 358681011548 SulA interaction site; other site 358681011549 Cell division ATPase FtsA [Cell division and chromosome partitioning]; Region: ftsA; COG0849 358681011550 Cell division protein FtsA; Region: FtsA; smart00842 358681011551 Cell division protein FtsA; Region: FtsA; pfam14450 358681011552 Protein of unknown function (DUF1290); Region: DUF1290; pfam06947 358681011553 Bacterial protein of unknown function (DUF881); Region: DUF881; pfam05949 358681011554 Bacterial protein of unknown function (DUF881); Region: DUF881; pfam05949 358681011555 POTRA domain, FtsQ-type; Region: POTRA_1; pfam08478 358681011556 Cell division protein FtsQ; Region: FtsQ; pfam03799 358681011557 Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cl00938 358681011558 UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Region: murA; TIGR01072 358681011559 UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555 358681011560 hinge; other site 358681011561 active site 358681011562 UDP-N-acetylenolpyruvoylglucosamine reductase; Provisional; Region: murB; PRK13905 358681011563 FAD binding domain; Region: FAD_binding_4; pfam01565 358681011564 Ribosomal L29 protein/HIP. L29 is a protein of the large ribosomal Subunit. A homolog, called heparin/heparan sulfate interacting protein (HIP), has also been identified in mammals. L29 is located on the surface of the large ribosomal subunit, where it...; Region: Ribosomal_L29_HIP; cl09943 358681011565 UDP-N-acetylenolpyruvoylglucosamine reductase, C-terminal domain; Region: MurB_C; pfam02873 358681011566 undecaprenyldiphospho-muramoylpentapeptide beta-N- acetylglucosaminyltransferase; Provisional; Region: murG; PRK00726 358681011567 MurG is an N-acetylglucosaminyltransferase, the last enzyme involved in the intracellular phase of peptidoglycan biosynthesis. It transfers N-acetyl-D-glucosamine (GlcNAc) from UDP-GlcNAc to the C4 hydroxyl of a lipid-linked N-acetylmuramoyl pentapeptide...; Region: GT1_MurG; cd03785 358681011568 active site 358681011569 homodimer interface [polypeptide binding]; other site 358681011570 Cell cycle protein; Region: FTSW_RODA_SPOVE; cl00511 358681011571 UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase; Provisional; Region: murD; PRK02472 358681011572 TrkA-N domain; Region: TrkA_N; pfam02254 358681011573 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 358681011574 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 358681011575 phospho-N-acetylmuramoyl-pentapeptide-transferase; Provisional; Region: mraY; PRK00108 358681011576 Phospho-N-acetylmuramoyl-pentapeptide-transferase (mraY) is an enzyme responsible for the formation of the first lipid intermediate in the synthesis of bacterial cell wall peptidoglycan. It catalyzes the formation of...; Region: GT_MraY; cd06852 358681011577 Mg++ binding site [ion binding]; other site 358681011578 putative catalytic motif [active] 358681011579 putative substrate binding site [chemical binding]; other site 358681011580 UDP-N-acetylmuramoylalanyl-D-glutamate--2, 6-diaminopimelate ligase; Provisional; Region: murE; PRK00139 358681011581 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 358681011582 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 358681011583 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 358681011584 stage V sporulation protein D; Region: spoVD_pbp; TIGR02214 358681011585 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 358681011586 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 358681011587 PASTA domain. This domain is found at the C-termini of several Penicillin-binding proteins (PBPs) and bacterial serine/threonine kinases. It is a small globular fold consisting of 3 beta-sheets and an alpha-helix. The name PASTA is derived from PBP and...; Region: PASTA; cd06573 358681011588 stage V sporulation protein D; Region: spoVD_pbp; TIGR02214 358681011589 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 358681011590 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 358681011591 PASTA domain of PBP2x-like proteins, first repeat. Penicillin-binding proteins (PBPs) are the major targets for beta-lactam antibiotics, like penicillins and cephalosporins. Beta-lactam antibiotics specifically inhibit transpeptidase activity by...; Region: PASTA_Pbp2x-like_1; cd06576 358681011592 PASTA domain of PBP2x-like proteins, second repeat. Penicillin-binding proteins (PBPs) are the major targets for beta-lactam antibiotics, like penicillins and cephalosporins. Beta-lactam antibiotics specifically inhibit transpeptidase activity by...; Region: PASTA_Pbp2x-like_2; cd06575 358681011593 MraW methylase family; Region: Methyltransf_5; pfam01795 358681011594 16S rRNA m(4)C1402 methyltranserfase; Provisional; Region: PRK00050 358681011595 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2001 358681011596 MraZ protein; Region: MraZ; pfam02381 358681011597 MraZ protein; Region: MraZ; pfam02381 358681011598 S-adenosyl-L-homocysteine hydrolase; Provisional; Region: PRK05476 358681011599 S-Adenosylhomocysteine Hydrolase, NAD-binding and catalytic domains; Region: SAHH; cd00401 358681011600 homotetramer interface [polypeptide binding]; other site 358681011601 ligand binding site [chemical binding]; other site 358681011602 catalytic site [active] 358681011603 NAD binding site [chemical binding]; other site 358681011604 Transcriptional regulator [Transcription]; Region: LysR; COG0583 358681011605 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 358681011606 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 358681011607 dimerization interface [polypeptide binding]; other site 358681011608 putative transporter; Provisional; Region: PRK11021 358681011609 S-layer homology domain; Region: SLH; pfam00395 358681011610 S-layer homology domain; Region: SLH; pfam00395 358681011611 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643 358681011612 Uncharacterized protein conserved in bacteria (DUF2317); Region: DUF2317; pfam10079 358681011613 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4365 358681011614 DNA-binding transcriptional repressor PuuR; Provisional; Region: PRK09943 358681011615 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 358681011616 non-specific DNA binding site [nucleotide binding]; other site 358681011617 salt bridge; other site 358681011618 sequence-specific DNA binding site [nucleotide binding]; other site 358681011619 Cupin domain; Region: Cupin_2; pfam07883 358681011620 2-dehydropantoate 2-reductase; Region: apbA_panE; TIGR00745 358681011621 Ketopantoate reductase PanE/ApbA; Region: ApbA; pfam02558 358681011622 Ketopantoate reductase PanE/ApbA C terminal; Region: ApbA_C; pfam08546 358681011623 Acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta) [Lipid metabolism]; Region: COG4799 358681011624 Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; cl17345 358681011625 Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; cl17345 358681011626 enoyl-CoA hydratase; Provisional; Region: PRK07657 358681011627 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 358681011628 substrate binding site [chemical binding]; other site 358681011629 oxyanion hole (OAH) forming residues; other site 358681011630 trimer interface [polypeptide binding]; other site 358681011631 Isopropylmalate/homocitrate/citramalate synthases [Amino acid transport and metabolism]; Region: LeuA; COG0119 358681011632 3-hydroxy-3-methylglutaryl-CoA lyase, catalytic TIM barrel domain; Region: DRE_TIM_HMGL; cd07938 358681011633 active site 358681011634 catalytic residues [active] 358681011635 metal binding site [ion binding]; metal-binding site 358681011636 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 358681011637 carboxyltransferase (CT) interaction site; other site 358681011638 biotinylation site [posttranslational modification]; other site 358681011639 acetyl-CoA carboxylase biotin carboxylase subunit; Validated; Region: PRK06111 358681011640 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 358681011641 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786 358681011642 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 358681011643 hypothetical protein; Provisional; Region: PRK13688 358681011644 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 358681011645 Coenzyme A binding pocket [chemical binding]; other site 358681011646 transcription factor, RsfA family; Region: DNA_bind_RsfA; TIGR02894 358681011647 putative spore coat protein regulator protein YlbO; Provisional; Region: PRK13923 358681011648 Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024 358681011649 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 358681011650 substrate binding site [chemical binding]; other site 358681011651 oxyanion hole (OAH) forming residues; other site 358681011652 trimer interface [polypeptide binding]; other site 358681011653 Arsenate Reductase (ArsC) family, Spx subfamily; Spx is a unique RNA polymerase (RNAP)-binding protein present in bacilli and some mollicutes. It inhibits transcription by binding to the C-terminal domain of the alpha subunit of RNAP, disrupting complex...; Region: ArsC_Spx; cd03032 358681011654 ArsC family; Region: ArsC; pfam03960 358681011655 putative catalytic residues [active] 358681011656 thiol/disulfide switch; other site 358681011657 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 358681011658 putative DNA binding site [nucleotide binding]; other site 358681011659 dimerization interface [polypeptide binding]; other site 358681011660 Predicted transcriptional regulator [Transcription]; Region: COG2345 358681011661 putative Zn2+ binding site [ion binding]; other site 358681011662 Protein of unknown function (DUF2626); Region: DUF2626; pfam11117 358681011663 Uncharacterized conserved protein [Function unknown]; Region: COG1565 358681011664 Bacterial capsule synthesis protein PGA_cap; Region: PGA_cap; smart00854 358681011665 CapA and related proteins, metallophosphatase domain; Region: MPP_CapA; cd07381 358681011666 putative active site [active] 358681011667 putative metal binding site [ion binding]; other site 358681011668 Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491 358681011669 DinB superfamily; Region: DinB_2; pfam12867 358681011670 NYN ribonuclease and ATPase of PhoH family domains [General function prediction only]; Region: COG1875 358681011671 PIN domain of bacterial Smg6-like homologs with PhoH-like ATPase domains; Region: PIN_PhoHL-ATPase; cd09883 358681011672 putative active site [active] 358681011673 PhoH-like protein; Region: PhoH; pfam02562 358681011674 sporulation lipoprotein, YhcN/YlaJ family; Region: spore_YhcN_YlaJ; TIGR02898 358681011675 Sporulation lipoprotein YhcN/YlaJ (Spore_YhcN_YlaJ); Region: Spore_YhcN_YlaJ; pfam09580 358681011676 cystathionine beta-lyase; Provisional; Region: PRK08064 358681011677 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 358681011678 homodimer interface [polypeptide binding]; other site 358681011679 substrate-cofactor binding pocket; other site 358681011680 pyridoxal 5'-phosphate binding site [chemical binding]; other site 358681011681 catalytic residue [active] 358681011682 cystathionine gamma-synthase; Reviewed; Region: PRK08247 358681011683 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 358681011684 homodimer interface [polypeptide binding]; other site 358681011685 substrate-cofactor binding pocket; other site 358681011686 pyridoxal 5'-phosphate binding site [chemical binding]; other site 358681011687 catalytic residue [active] 358681011688 hypothetical protein; Provisional; Region: PRK06733 358681011689 YlaH-like protein; Region: YlaH; pfam14036 358681011690 Glutathione (GSH) peroxidase family; tetrameric selenoenzymes that catalyze the reduction of a variety of hydroperoxides including lipid peroxidases, using GSH as a specific electron donor substrate. GSH peroxidase contains one selenocysteine residue per...; Region: GSH_Peroxidase; cd00340 358681011691 catalytic residues [active] 358681011692 dimer interface [polypeptide binding]; other site 358681011693 Predicted membrane GTPase involved in stress response [Signal transduction mechanisms]; Region: TypA; COG1217 358681011694 Tyrosine phosphorylated protein A (TypA)/BipA family belongs to ribosome-binding GTPases; Region: TypA_BipA; cd01891 358681011695 G1 box; other site 358681011696 putative GEF interaction site [polypeptide binding]; other site 358681011697 GTP/Mg2+ binding site [chemical binding]; other site 358681011698 Switch I region; other site 358681011699 G2 box; other site 358681011700 G3 box; other site 358681011701 Switch II region; other site 358681011702 G4 box; other site 358681011703 G5 box; other site 358681011704 BipA_TypA_II: domain II of BipA (also called TypA) having homology to domain II of the elongation factors (EFs) EF-G and EF-Tu. BipA is a highly conserved protein with global regulatory properties in Escherichia coli. BipA is phosphorylated on a...; Region: BipA_TypA_II; cd03691 358681011705 BipA_TypA_C: a C-terminal portion of BipA or TypA having homology to the C terminal domains of the elongation factors EF-G and EF-2. A member of the ribosome binding GTPase superfamily, BipA is widely distributed in bacteria and plants. BipA is a highly...; Region: BipA_TypA_C; cd03710 358681011706 Sporulation lipoprotein YhcN/YlaJ (Spore_YhcN_YlaJ); Region: Spore_YhcN_YlaJ; pfam09580 358681011707 S-adenosylmethionine decarboxylase proenzyme; Validated; Region: PRK01706 358681011708 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 358681011709 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 358681011710 Coenzyme A binding pocket [chemical binding]; other site 358681011711 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4493 358681011712 Protein of unknown function (DUF1054); Region: DUF1054; pfam06335 358681011713 Dioxygenases related to 2-nitropropane dioxygenase [General function prediction only]; Region: COG2070 358681011714 2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730 358681011715 FMN binding site [chemical binding]; other site 358681011716 substrate binding site [chemical binding]; other site 358681011717 putative catalytic residue [active] 358681011718 Arginine/lysine/ornithine decarboxylases [Amino acid transport and metabolism]; Region: LdcC; COG1982 358681011719 Ornithine decarboxylase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to ornithine decarboxylase (ODC), arginine decarboxylase (ADC) and lysine...; Region: Orn_deC_like; cd00615 358681011720 homodimer interface [polypeptide binding]; other site 358681011721 pyridoxal 5'-phosphate binding site [chemical binding]; other site 358681011722 catalytic residue [active] 358681011723 Orn/Lys/Arg decarboxylase, C-terminal domain; Region: OKR_DC_1_C; pfam03711 358681011724 dihydroorotate dehydrogenase 2; Reviewed; Region: PRK05286 358681011725 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 358681011726 phosphate binding site [ion binding]; other site 358681011727 potential frameshift: common BLAST hit: gi|51893870|ref|YP_076561.1| group II intron-encoding maturase 358681011728 Group II intron, maturase-specific domain; Region: GIIM; pfam08388 358681011729 Retron-type reverse transcriptase [DNA replication, recombination, and repair]; Region: COG3344 358681011730 RT_G2_intron: Reverse transcriptases (RTs) with group II intron origin. RT transcribes DNA using RNA as template. Proteins in this subfamily are found in bacterial and mitochondrial group II introns. Their most probable ancestor was a retrotransposable...; Region: RT_G2_intron; cd01651 358681011731 putative active site [active] 358681011732 putative NTP binding site [chemical binding]; other site 358681011733 putative nucleic acid binding site [nucleotide binding]; other site 358681011734 beta propeller repeat, Methanosarcina surface protein type; Region: beta_prop_Msarc; TIGR04275 358681011735 beta propeller repeat, Methanosarcina surface protein type; Region: beta_prop_Msarc; TIGR04275 358681011736 Domain of unknown function (DUF4182); Region: DUF4182; pfam13790 358681011737 Lysophospholipase [Lipid metabolism]; Region: PldB; COG2267 358681011738 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 358681011739 Protein of unknown function (DUF3055); Region: DUF3055; pfam11256 358681011740 Predicted transcriptional regulators [Transcription]; Region: COG1695 358681011741 MarR family; Region: MarR_2; pfam12802 358681011742 Domain of unknown function (DUF1885); Region: DUF1885; pfam08968 358681011743 Muramidase (flagellum-specific) [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FlgJ; COG1705 358681011744 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3330 358681011745 M20 Peptidase Aminoacyclase-1 YkuR-like proteins, including YkuR and Ama/HipO/HyuC proteins; Region: M20_Acy1_YkuR_like; cd05670 358681011746 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 358681011747 metal binding site [ion binding]; metal-binding site 358681011748 putative dimer interface [polypeptide binding]; other site 358681011749 acetylornithine aminotransferase; Provisional; Region: PRK02627 358681011750 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 358681011751 inhibitor-cofactor binding pocket; inhibition site 358681011752 pyridoxal 5'-phosphate binding site [chemical binding]; other site 358681011753 catalytic residue [active] 358681011754 Tetrahydrodipicolinate succinyltransferase N-terminal; Region: DapH_N; pfam08503 358681011755 2,3,4,5-tetrahydropyridine-2,6-dicarboxylate N-acetyltransferase; Region: DapD_Ac; TIGR03532 358681011756 2,3,4,5-tetrahydropyridine-2,6-dicarboxylate (THDP) N-succinyltransferase (also called THP succinyltransferase): THDP N-succinyltransferase catalyzes the conversion of tetrahydrodipicolinate and succinyl-CoA to N-succinyltetrahydrodipicolinate and CoA; Region: LbH_THP_succinylT; cd03350 358681011757 active site 358681011758 trimer interface [polypeptide binding]; other site 358681011759 substrate binding site [chemical binding]; other site 358681011760 CoA binding site [chemical binding]; other site 358681011761 flavodoxin; Provisional; Region: PRK06756 358681011762 Uncharacterized flavoproteins [Energy production and conversion]; Region: FpaA; COG0426 358681011763 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 358681011764 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 358681011765 EcsC protein family; Region: EcsC; pfam12787 358681011766 Trans-aconitate methyltransferase [General function prediction only]; Region: Tam; COG4106 358681011767 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 358681011768 S-adenosylmethionine binding site [chemical binding]; other site 358681011769 Asp/Glu/Hydantoin racemase; Region: Asp_Glu_race; pfam01177 358681011770 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 358681011771 carboxyltransferase (CT) interaction site; other site 358681011772 biotinylation site [posttranslational modification]; other site 358681011773 HlyD family secretion protein; Region: HlyD_3; pfam13437 358681011774 HlyD family secretion protein; Region: HlyD_3; pfam13437 358681011775 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 358681011776 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 358681011777 ABC-type transport system, involved in lipoprotein release, permease component [Cell envelope biogenesis, outer membrane]; Region: LolE; COG4591 358681011778 FtsX-like permease family; Region: FtsX; pfam02687 358681011779 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 358681011780 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 358681011781 Walker A/P-loop; other site 358681011782 ATP binding site [chemical binding]; other site 358681011783 Q-loop/lid; other site 358681011784 ABC transporter signature motif; other site 358681011785 Walker B; other site 358681011786 D-loop; other site 358681011787 H-loop/switch region; other site 358681011788 4-amino-5-hydroxymethyl-2-methyl-pyrimidine phosphate kinase (HMPP-kinase) catalyzes two consecutive phosphorylation steps in the thiamine phosphate biosynthesis pathway, leading to the synthesis of vitamin B1. The first step is the phosphorylation of...; Region: HMPP_kinase; cd01169 358681011789 dimer interface [polypeptide binding]; other site 358681011790 substrate binding site [chemical binding]; other site 358681011791 ATP binding site [chemical binding]; other site 358681011792 Predicted permeases [General function prediction only]; Region: RarD; COG2962 358681011793 EamA-like transporter family; Region: EamA; cl17759 358681011794 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 358681011795 EamA-like transporter family; Region: EamA; pfam00892 358681011796 Bleomycin binding protein (BLMA) and similar proteins; BLMA confers bleomycin (Bm) resistance by directly binding to Bm; Region: BLMA_like; cd08349 358681011797 dimer interface [polypeptide binding]; other site 358681011798 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 358681011799 ligand binding site [chemical binding]; other site 358681011800 4-methyl-5-beta-hydroxyethylthiazole (Thz) kinase catalyzes the phosphorylation of the hydroxylgroup of Thz. A reaction that allows cells to recycle Thz into the thiamine biosynthesis pathway, as an alternative to its synthesis from cysteine, tyrosine...; Region: THZ_kinase; cd01170 358681011801 substrate binding site [chemical binding]; other site 358681011802 multimerization interface [polypeptide binding]; other site 358681011803 ATP binding site [chemical binding]; other site 358681011804 Uncharacterized protein family UPF0027; Region: UPF0027; pfam01139 358681011805 WYL domain; Region: WYL; pfam13280 358681011806 WYL domain; Region: WYL; pfam13280 358681011807 Bacterial SH3 domain; Region: SH3_3; pfam08239 358681011808 Bacterial SH3 domain; Region: SH3_3; pfam08239 358681011809 N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860 358681011810 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 358681011811 active site 358681011812 metal binding site [ion binding]; metal-binding site 358681011813 Uncharacterized conserved protein [Function unknown]; Region: COG1284 358681011814 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 358681011815 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 358681011816 Adenosylcobinamide kinase / adenosylcobinamide phosphate guanyltransferase (CobU). CobU is bifunctional cobalbumin biosynthesis enzymes which display adenosylcobinamide kinase and adenosylcobinamide phosphate guanyltransferase activity. This enzyme is a...; Region: CobU; cd00544 358681011817 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 358681011818 homotrimer interface [polypeptide binding]; other site 358681011819 Walker A motif; other site 358681011820 GTP binding site [chemical binding]; other site 358681011821 Walker B motif; other site 358681011822 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 358681011823 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 358681011824 Walker A/P-loop; other site 358681011825 ATP binding site [chemical binding]; other site 358681011826 Q-loop/lid; other site 358681011827 ABC transporter signature motif; other site 358681011828 Walker B; other site 358681011829 D-loop; other site 358681011830 H-loop/switch region; other site 358681011831 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 358681011832 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 358681011833 ABC-ATPase subunit interface; other site 358681011834 dimer interface [polypeptide binding]; other site 358681011835 putative PBP binding regions; other site 358681011836 ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614 358681011837 Periplasmic binding protein YvrC. These proteins are predicted to function as initial receptors in ABC transport of metal ions in eubacteria and archaea. They belong to the TroA superfamily of periplasmic metal binding proteins that share a distinct...; Region: YvrC; cd01143 358681011838 putative binding site residues; other site 358681011839 Uncharacterized flavoproteins [Energy production and conversion]; Region: FpaA; COG0426 358681011840 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 358681011841 Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_oxidase; pfam01243 358681011842 Helix-Turn-Helix DNA binding domain of the transcription regulators TipAL, Mta, and SkgA; Region: HTH_TipAL-Mta; cd01106 358681011843 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 358681011844 DNA binding residues [nucleotide binding] 358681011845 dimer interface [polypeptide binding]; other site 358681011846 TipAS antibiotic-recognition domain; Region: TipAS; pfam07739 358681011847 putative manganese-dependent inorganic pyrophosphatase; Provisional; Region: PRK05427 358681011848 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354 358681011849 DHHA2 domain; Region: DHHA2; pfam02833 358681011850 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 358681011851 active site 358681011852 metal binding site [ion binding]; metal-binding site 358681011853 Calcineurin-like phosphoesterase superfamily domain; Region: Metallophos_2; pfam12850 358681011854 Predicted membrane protein [Function unknown]; Region: COG3212 358681011855 Peptidase propeptide and YPEB domain; Region: PepSY; pfam03413 358681011856 RT_G2_intron: Reverse transcriptases (RTs) with group II intron origin. RT transcribes DNA using RNA as template. Proteins in this subfamily are found in bacterial and mitochondrial group II introns. Their most probable ancestor was a retrotransposable...; Region: RT_G2_intron; cd01651 358681011857 Reverse transcriptase (RNA-dependent DNA polymerase); Region: RVT_1; pfam00078 358681011858 putative active site [active] 358681011859 putative NTP binding site [chemical binding]; other site 358681011860 putative nucleic acid binding site [nucleotide binding]; other site 358681011861 Group II intron, maturase-specific domain; Region: GIIM; pfam08388 358681011862 ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614 358681011863 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 358681011864 intersubunit interface [polypeptide binding]; other site 358681011865 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 358681011866 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 358681011867 ABC-ATPase subunit interface; other site 358681011868 dimer interface [polypeptide binding]; other site 358681011869 putative PBP binding regions; other site 358681011870 ABC-type enterobactin transport system, permease component [Inorganic ion transport and metabolism]; Region: FepG; COG4779 358681011871 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 358681011872 ABC-ATPase subunit interface; other site 358681011873 dimer interface [polypeptide binding]; other site 358681011874 putative PBP binding regions; other site 358681011875 Nitroreductase-like family which includes NADH oxidase and arsenite oxidiase. NADH oxidase catalyses the oxidation of NAD(P)H and accepts a wide broad range of compounds as electron acceptors, such as nitrocompound. Arsenite oxidase in a...; Region: Arsenite_oxidase; cd02135 358681011876 putative FMN binding site [chemical binding]; other site 358681011877 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 358681011878 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 358681011879 ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614 358681011880 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 358681011881 intersubunit interface [polypeptide binding]; other site 358681011882 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 358681011883 classical (c) SDRs; Region: SDR_c; cd05233 358681011884 NAD(P) binding site [chemical binding]; other site 358681011885 active site 358681011886 Zinc ribbon domain; Region: CxxC_CxxC_SSSS; cl00993 358681011887 Acetamidase/Formamidase family; Region: FmdA_AmdA; pfam03069 358681011888 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 358681011889 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 358681011890 Walker A motif; other site 358681011891 ATP binding site [chemical binding]; other site 358681011892 Walker B motif; other site 358681011893 arginine finger; other site 358681011894 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 358681011895 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270 358681011896 active site 358681011897 substrate binding site [chemical binding]; other site 358681011898 ATP binding site [chemical binding]; other site 358681011899 Phosphotransferase enzyme family; Region: APH; pfam01636 358681011900 Predicted transcriptional regulator [Transcription]; Region: COG2345 358681011901 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 358681011902 putative DNA binding site [nucleotide binding]; other site 358681011903 putative Zn2+ binding site [ion binding]; other site 358681011904 UDP-N-acetylenolpyruvoylglucosamine reductase; Provisional; Region: murB; PRK13905 358681011905 FAD binding domain; Region: FAD_binding_4; pfam01565 358681011906 UDP-N-acetylenolpyruvoylglucosamine reductase, C-terminal domain; Region: MurB_C; pfam02873 358681011907 Fe-S cluster assembly scaffold protein [Posttranslational modification, protein turnover, chaperones]; Region: sufA; COG0316 358681011908 drug resistance transporter, Bcr/CflA subfamily; Region: efflux_Bcr_CflA; TIGR00710 358681011909 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 358681011910 putative substrate translocation pore; other site 358681011911 MutS domain III; Region: MutS_III; pfam05192 358681011912 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 358681011913 Walker A/P-loop; other site 358681011914 ATP binding site [chemical binding]; other site 358681011915 Q-loop/lid; other site 358681011916 ABC transporter signature motif; other site 358681011917 Walker B; other site 358681011918 D-loop; other site 358681011919 H-loop/switch region; other site 358681011920 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 358681011921 Beta-lactamase; Region: Beta-lactamase; pfam00144 358681011922 Predicted transcriptional regulators [Transcription]; Region: COG1695 358681011923 Transcriptional regulator PadR-like family; Region: PadR; pfam03551 358681011924 Protein of unknown function (DUF1700); Region: DUF1700; pfam08006 358681011925 Putative glycolipid-binding; Region: Glycolipid_bind; pfam06475 358681011926 Monoamine oxidase [Amino acid transport and metabolism]; Region: COG1231 358681011927 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 358681011928 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 358681011929 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 358681011930 Protein of unknown function (DUF3238); Region: DUF3238; pfam11579 358681011931 Ketopantoate reductase [Coenzyme metabolism]; Region: ApbA; COG1893 358681011932 Ketopantoate reductase PanE/ApbA; Region: ApbA; pfam02558 358681011933 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 358681011934 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 358681011935 Transcriptional regulator C-terminal region; Region: TetR_C_8; pfam14278 358681011936 Gluconate kinase (GntK) catalyzes the phosphoryl transfer from ATP to gluconate. The resulting product gluconate-6-phoshate is an important precursor of gluconate metabolism. GntK acts as a dimmer composed of two identical subunits; Region: GntK; cd02021 358681011937 AAA domain; Region: AAA_33; pfam13671 358681011938 ATP-binding site [chemical binding]; other site 358681011939 Gluconate-6-phosphate binding site [chemical binding]; other site 358681011940 FAD dependent oxidoreductase; Region: FAD_oxidored; pfam12831 358681011941 Na+/glutamate symporter [Amino acid transport and metabolism]; Region: GltS; COG0786 358681011942 formimidoylglutamase; Provisional; Region: PRK13775 358681011943 Formimidoylglutamase or HutE; Region: Formimidoylglutamase; cd09988 358681011944 putative active site [active] 358681011945 putative metal binding site [ion binding]; other site 358681011946 Transcriptional regulator [Transcription]; Region: LysR; COG0583 358681011947 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 358681011948 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 358681011949 dimerization interface [polypeptide binding]; other site 358681011950 cell division protein ZipA; Provisional; Region: PRK01741 358681011951 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 358681011952 Cytochrome P450; Region: p450; cl12078 358681011953 Uncharacterized protein containing a NRPS condensation (elongation) domain [General function prediction only]; Region: COG4908 358681011954 Glutamine amidotransferases class-II (GATase) asparagine synthase_B type. Asparagine synthetase B catalyses the ATP-dependent conversion of aspartate to asparagine. This enzyme is a homodimer, with each monomer composed of a glutaminase domain and a...; Region: AsnB; cd00712 358681011955 active site 358681011956 asparagine synthase (glutamine-hydrolyzing); Region: asn_synth_AEB; TIGR01536 358681011957 dimer interface [polypeptide binding]; other site 358681011958 The C-terminal domain of Asparagine Synthase B. This domain is always found associated n-terminal amidotransferase domain. Family members that contain this domain catalyse the conversion of aspartate to asparagine. Asparagine synthetase B catalyzes the...; Region: Asn_Synthase_B_C; cd01991 358681011959 Ligand Binding Site [chemical binding]; other site 358681011960 Molecular Tunnel; other site 358681011961 Condensation domain; Region: Condensation; pfam00668 358681011962 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 358681011963 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 358681011964 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 358681011965 acyl-activating enzyme (AAE) consensus motif; other site 358681011966 AMP binding site [chemical binding]; other site 358681011967 Methyltransferase domain; Region: Methyltransf_31; pfam13847 358681011968 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 358681011969 S-adenosylmethionine binding site [chemical binding]; other site 358681011970 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 358681011971 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 358681011972 Condensation domain; Region: Condensation; pfam00668 358681011973 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 358681011974 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 358681011975 S-adenosylmethionine binding site [chemical binding]; other site 358681011976 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 358681011977 Beta-ketoacyl synthase; Region: PKS_KS; smart00825 358681011978 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 358681011979 active site 358681011980 Methyltransferase in polyketide synthase (PKS) enzymes; Region: PKS_MT; smart00828 358681011981 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 358681011982 S-adenosylmethionine binding site [chemical binding]; other site 358681011983 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 358681011984 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 358681011985 Beta-ketoacyl synthase; Region: PKS_KS; smart00825 358681011986 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 358681011987 active site 358681011988 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 358681011989 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 358681011990 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 358681011991 3-oxoacyl-(acyl-carrier-protein) synthase [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: FabB; COG0304 358681011992 active site 358681011993 Polyketide synthase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3321 358681011994 Dehydratase domain in polyketide synthase (PKS) enzymes; Region: PKS_DH; smart00826 358681011995 ketoreductase (KR), subgroup 2, complex (x) SDRs; Region: KR_2_SDR_x; cd08953 358681011996 putative NADP binding site [chemical binding]; other site 358681011997 This enzymatic domain is part of bacterial polyketide synthases; Region: PKS_KR; smart00822 358681011998 active site 358681011999 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 358681012000 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 358681012001 Polyketide synthase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3321 358681012002 active site 358681012003 Dehydratase domain in polyketide synthase (PKS) enzymes; Region: PKS_DH; smart00826 358681012004 ketoreductase (KR), subgroup 2, complex (x) SDRs; Region: KR_2_SDR_x; cd08953 358681012005 putative NADP binding site [chemical binding]; other site 358681012006 This enzymatic domain is part of bacterial polyketide synthases; Region: PKS_KR; smart00822 358681012007 active site 358681012008 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 358681012009 Condensation domain; Region: Condensation; pfam00668 358681012010 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 358681012011 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 358681012012 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 358681012013 acyl-activating enzyme (AAE) consensus motif; other site 358681012014 AMP binding site [chemical binding]; other site 358681012015 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 358681012016 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 358681012017 Beta-ketoacyl synthase; Region: PKS_KS; smart00825 358681012018 active site 358681012019 ketoreductase (KR), subgroup 2, complex (x) SDRs; Region: KR_2_SDR_x; cd08953 358681012020 KR domain; Region: KR; pfam08659 358681012021 putative NADP binding site [chemical binding]; other site 358681012022 active site 358681012023 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 358681012024 Polyketide synthase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3321 358681012025 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 358681012026 active site 358681012027 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 358681012028 Dehydratase domain in polyketide synthase (PKS) enzymes; Region: PKS_DH; smart00826 358681012029 ketoreductase (KR), subgroup 2, complex (x) SDRs; Region: KR_2_SDR_x; cd08953 358681012030 This enzymatic domain is part of bacterial polyketide synthases; Region: PKS_KR; smart00822 358681012031 putative NADP binding site [chemical binding]; other site 358681012032 active site 358681012033 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 358681012034 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 358681012035 Polyketide synthase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3321 358681012036 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 358681012037 active site 358681012038 Dehydratase domain in polyketide synthase (PKS) enzymes; Region: PKS_DH; smart00826 358681012039 ketoreductase (KR), subgroup 2, complex (x) SDRs; Region: KR_2_SDR_x; cd08953 358681012040 putative NADP binding site [chemical binding]; other site 358681012041 KR domain; Region: KR; pfam08659 358681012042 active site 358681012043 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 358681012044 Polyketide synthase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3321 358681012045 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 358681012046 active site 358681012047 ketoreductase (KR), subgroup 2, complex (x) SDRs; Region: KR_2_SDR_x; cd08953 358681012048 putative NADP binding site [chemical binding]; other site 358681012049 active site 358681012050 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 358681012051 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 358681012052 Beta-ketoacyl synthase; Region: PKS_KS; smart00825 358681012053 active site 358681012054 Methyltransferase domain; Region: Methyltransf_23; pfam13489 358681012055 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 358681012056 S-adenosylmethionine binding site [chemical binding]; other site 358681012057 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 358681012058 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 358681012059 Beta-ketoacyl synthase; Region: PKS_KS; smart00825 358681012060 active site 358681012061 Dehydratase domain in polyketide synthase (PKS) enzymes; Region: PKS_DH; smart00826 358681012062 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 358681012063 Polyketide synthase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3321 358681012064 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 358681012065 active site 358681012066 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 358681012067 Dehydratase domain in polyketide synthase (PKS) enzymes; Region: PKS_DH; smart00826 358681012068 ketoreductase (KR), subgroup 2, complex (x) SDRs; Region: KR_2_SDR_x; cd08953 358681012069 KR domain; Region: KR; pfam08659 358681012070 putative NADP binding site [chemical binding]; other site 358681012071 active site 358681012072 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 358681012073 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 358681012074 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 358681012075 Beta-ketoacyl synthase; Region: PKS_KS; smart00825 358681012076 active site 358681012077 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 358681012078 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 358681012079 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 358681012080 Beta-ketoacyl synthase; Region: PKS_KS; smart00825 358681012081 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 358681012082 active site 358681012083 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 358681012084 S-adenosylmethionine binding site [chemical binding]; other site 358681012085 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 358681012086 Polyketide synthase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3321 358681012087 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 358681012088 active site 358681012089 Dehydratase domain in polyketide synthase (PKS) enzymes; Region: PKS_DH; smart00826 358681012090 ketoreductase (KR), subgroup 2, complex (x) SDRs; Region: KR_2_SDR_x; cd08953 358681012091 putative NADP binding site [chemical binding]; other site 358681012092 This enzymatic domain is part of bacterial polyketide synthases; Region: PKS_KR; smart00822 358681012093 active site 358681012094 Methyltransferase domain; Region: Methyltransf_31; pfam13847 358681012095 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 358681012096 S-adenosylmethionine binding site [chemical binding]; other site 358681012097 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 358681012098 methyl indole-3-acetate methyltransferase; Region: PLN02211; cl17657 358681012099 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 358681012100 Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827 358681012101 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 358681012102 (acyl-carrier-protein) S-malonyltransferase [Lipid metabolism]; Region: FabD; COG0331 358681012103 2-Nitropropane dioxygenase (NPD)-like domain, associated with the (acyl-carrier-protein) S-malonyltransferase FabD. NPD is part of the nitroalkaneoxidizing enzyme family, that catalyzes oxidative denitrification of nitroalkanes to their corresponding...; Region: NPD_FabD; cd04742 358681012104 FMN binding site [chemical binding]; other site 358681012105 substrate binding site [chemical binding]; other site 358681012106 putative catalytic residue [active] 358681012107 4'-phosphopantetheinyl transferase superfamily; Region: ACPS; cl00500 358681012108 4'-phosphopantetheinyl transferase superfamily; Region: ACPS; pfam01648 358681012109 Transcription antiterminator [Transcription]; Region: NusG; COG0250 358681012110 N-Utilization Substance G (NusG) N-terminal (NGN) domain Superfamily; Region: NGN; cd08000 358681012111 NusG contains an NGN domain at its N-terminus and KOW motif at its C-terminus; Region: KOW_NusG; cd06091 358681012112 heterodimer interface [polypeptide binding]; other site 358681012113 homodimer interface [polypeptide binding]; other site 358681012114 Lipase (class 3). Lipases are esterases that can hydrolyze long-chain acyl-triglycerides into di- and monoglycerides, glycerol, and free fatty acids at a water/lipid interface. A typical feature of lipases is "interfacial activation," the...; Region: Lipase_3; cd00519 358681012115 active site flap/lid [active] 358681012116 nucleophilic elbow; other site 358681012117 catalytic triad [active] 358681012118 Lipase (class 3). Lipases are esterases that can hydrolyze long-chain acyl-triglycerides into di- and monoglycerides, glycerol, and free fatty acids at a water/lipid interface. A typical feature of lipases is "interfacial activation," the...; Region: Lipase_3; cd00519 358681012119 active site flap/lid [active] 358681012120 nucleophilic elbow; other site 358681012121 catalytic triad [active] 358681012122 F0F1 ATP synthase subunit alpha; Validated; Region: PRK06763 358681012123 cyclic lactone autoinducer peptide; Region: quorum_AgrD; TIGR04223 358681012124 Accessory gene regulator B; Region: AgrB; cl01873 358681012125 Domain of unknown function (DUF4280); Region: DUF4280; pfam14107 358681012126 HD domain; Region: HD_4; pfam13328 358681012127 Phosphatidylglycerophosphatase A; a bacterial membrane-associated enzyme involved in lipid metabolism; Region: PgpA; cd06971 358681012128 tetramer interfaces [polypeptide binding]; other site 358681012129 binuclear metal-binding site [ion binding]; other site 358681012130 Predicted hydrolase of the alpha/beta superfamily [General function prediction only]; Region: COG2819 358681012131 Putative esterase; Region: Esterase; pfam00756 358681012132 hypothetical protein; Provisional; Region: PRK13679 358681012133 LigT like Phosphoesterase; Region: LigT_PEase; pfam02834 358681012134 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 358681012135 Coenzyme A binding pocket [chemical binding]; other site 358681012136 NAD binding domain of 6-phosphogluconate dehydrogenase; Region: NAD_binding_2; pfam03446 358681012137 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210 358681012138 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 358681012139 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 358681012140 Protein of unknown function (DUF3995); Region: DUF3995; pfam13160 358681012141 Predicted metal-dependent phosphoesterases (PHP family) [General function prediction only]; Region: COG0613 358681012142 Polymerase and Histidinol Phosphatase domain of Histidinol phosphate phosphatase (HisPPase) AMP bound; Region: PHP_HisPPase_AMP; cd07438 358681012143 active site 358681012144 Polymerase and Histidinol Phosphatase domain of Histidinol phosphate phosphatase (HisPPase) AMP bound; Region: PHP_HisPPase_AMP; cd07438 358681012145 YugN-like family; Region: YugN; pfam08868 358681012146 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 358681012147 Uncharacterized conserved protein [Function unknown]; Region: COG1284 358681012148 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 358681012149 Domain of unknown function DUF21; Region: DUF21; pfam01595 358681012150 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 358681012151 Transporter associated domain; Region: CorC_HlyC; smart01091 358681012152 Competence protein CoiA-like family; Region: CoiA; cl11541 358681012153 Superfamily I DNA and RNA helicases [DNA replication, recombination, and repair]; Region: UvrD; COG0210 358681012154 Part of AAA domain; Region: AAA_19; pfam13245 358681012155 Family description; Region: UvrD_C_2; pfam13538 358681012156 enoyl-(acyl carrier protein) reductase; Provisional; Region: PRK08594 358681012157 Enoyl acyl carrier protein (ACP) reductase (ENR), divergent SDR; Region: ENR_SDR; cd05372 358681012158 NAD binding site [chemical binding]; other site 358681012159 homotetramer interface [polypeptide binding]; other site 358681012160 homodimer interface [polypeptide binding]; other site 358681012161 substrate binding site [chemical binding]; other site 358681012162 active site 358681012163 Predicted divalent heavy-metal cations transporter [Inorganic ion transport and metabolism]; Region: COG0428; cl00437 358681012164 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 358681012165 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 358681012166 DNA binding residues [nucleotide binding] 358681012167 c-di-GMP phosphodiesterase class II (HD-GYP domain) [Signal transduction mechanisms]; Region: COG2206 358681012168 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 358681012169 Zn2+ binding site [ion binding]; other site 358681012170 Mg2+ binding site [ion binding]; other site 358681012171 integral membrane protein, YjbE family; Region: R_switched_YjbE; TIGR03717 358681012172 CheW, a small regulator protein, unique to the chemotaxis signalling in prokaryotes and archea. CheW interacts with the histidine kinase CheA, most likely with the related regulatory domain of CheA. CheW is proposed to form signalling arrays together...; Region: CheW; cd00732 358681012173 putative CheA interaction surface; other site 358681012174 2'-5' RNA ligase; Region: 2_5_ligase; TIGR02258 358681012175 LigT like Phosphoesterase; Region: LigT_PEase; pfam02834 358681012176 5'(3')-nucleotidase/polyphosphatase; Provisional; Region: surE; PRK00346 358681012177 tellurium resistance terB-like protein; Region: terB_like; cd07177 358681012178 metal binding site [ion binding]; metal-binding site 358681012179 Sugar transport-related sRNA regulator N-term; Region: SgrR_N; pfam12793 358681012180 ABC-type uncharacterized transport system, periplasmic component [General function prediction only]; Region: COG4533 358681012181 The C-terminal solute-binding domain of DNA-binding transcriptional regulator SgrR is related to the ABC-type oligopeptide-binding proteins and contains the type 2 periplasmic-binding fold; Region: PBP2_SgrR_like; cd08507 358681012182 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 358681012183 Major Facilitator Superfamily; Region: MFS_1; pfam07690 358681012184 putative substrate translocation pore; other site 358681012185 ABC-type uncharacterized transport system, ATPase component [General function prediction only]; Region: PhnK; COG1101 358681012186 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 358681012187 Walker A/P-loop; other site 358681012188 ATP binding site [chemical binding]; other site 358681012189 Q-loop/lid; other site 358681012190 ABC transporter signature motif; other site 358681012191 Walker B; other site 358681012192 D-loop; other site 358681012193 H-loop/switch region; other site 358681012194 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 358681012195 Transmembrane subunit (TM) of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which are involved in the uptake of branched-chain amino acids (AAs), as well as TMs of transporters involved in the uptake of...; Region: TM_PBP1_branched-chain-AA_like; cd06574 358681012196 TM-ABC transporter signature motif; other site 358681012197 Type I periplasmic ligand-binding domain of uncharacterized ABC-type transport systems that are predicted to be involved in the uptake of amino acids, peptides, or inorganic ions; Region: PBP1_ABC_uncharacterized_transporter; cd06325 358681012198 zinc binding site [ion binding]; other site 358681012199 putative ligand binding site [chemical binding]; other site 358681012200 Type I periplasmic ligand-binding domain of uncharacterized ABC-type transport systems that are predicted to be involved in the uptake of amino acids, peptides, or inorganic ions; Region: PBP1_ABC_uncharacterized_transporter; cd06325 358681012201 zinc binding site [ion binding]; other site 358681012202 putative ligand binding site [chemical binding]; other site 358681012203 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 358681012204 Domain of unknown function DUF21; Region: DUF21; pfam01595 358681012205 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 358681012206 Transporter associated domain; Region: CorC_HlyC; smart01091 358681012207 Helicase conserved C-terminal domain; Region: Helicase_C_3; pfam13625 358681012208 DNA or RNA helicases of superfamily II [Transcription / DNA replication, recombination, and repair]; Region: SSL2; COG1061 358681012209 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 358681012210 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 358681012211 ATP binding site [chemical binding]; other site 358681012212 putative Mg++ binding site [ion binding]; other site 358681012213 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 358681012214 nucleotide binding region [chemical binding]; other site 358681012215 ATP-binding site [chemical binding]; other site 358681012216 DNA-directed RNA polymerase specialized sigma subunit, sigma24 homolog [Transcription]; Region: RpoE; COG1595 358681012217 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 358681012218 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 358681012219 DNA binding residues [nucleotide binding] 358681012220 Protein of unknown function (DUF2573); Region: DUF2573; pfam10835 358681012221 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 358681012222 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 358681012223 Coenzyme A binding pocket [chemical binding]; other site 358681012224 ABC-type transport system involved in multi-copper enzyme maturation, permease component [General function prediction only]; Region: NosY; COG1277 358681012225 ABC-2 family transporter protein; Region: ABC2_membrane_4; pfam12730 358681012226 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 358681012227 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 358681012228 Walker A/P-loop; other site 358681012229 ATP binding site [chemical binding]; other site 358681012230 Q-loop/lid; other site 358681012231 ABC transporter signature motif; other site 358681012232 Walker B; other site 358681012233 D-loop; other site 358681012234 H-loop/switch region; other site 358681012235 SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cl01053 358681012236 active site 358681012237 catalytic triad [active] 358681012238 oxyanion hole [active] 358681012239 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 358681012240 putative substrate translocation pore; other site 358681012241 putative transporter; Provisional; Region: PRK10054 358681012242 Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491 358681012243 2,4-dienoyl-CoA reductase (DCR) FMN-binding domain. DCR in E. coli is an iron-sulfur flavoenzyme which contains FMN, FAD, and a 4Fe-4S cluster. It is also a monomer, unlike that of its eukaryotic counterparts which form homotetramers and lack the...; Region: DCR_FMN; cd02930 358681012244 mycofactocin system FadH/OYE family oxidoreductase 2; Region: mycofact_OYE_2; TIGR03997 358681012245 active site 358681012246 FMN binding site [chemical binding]; other site 358681012247 2,4-decadienoyl-CoA binding site; other site 358681012248 catalytic residue [active] 358681012249 4Fe-4S cluster binding site [ion binding]; other site 358681012250 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 358681012251 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643 358681012252 hydrophobic ligand binding site; other site 358681012253 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_24; cd09012 358681012254 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 358681012255 Imidazolonepropionase and related amidohydrolases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: HutI; COG1228 358681012256 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 358681012257 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 358681012258 active site 358681012259 MarR family; Region: MarR_2; cl17246 358681012260 Transcriptional regulator [Transcription]; Region: LytR; COG1316 358681012261 YeiC-like sugar kinase. Found in eukaryotes and bacteria, YeiC-like kinase is part of the ribokinase/pfkB sugar kinase superfamily. Its oligomerization state is unknown at this time; Region: YeiC_kinase_like; cd01941 358681012262 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 358681012263 substrate binding site [chemical binding]; other site 358681012264 ATP binding site [chemical binding]; other site 358681012265 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 358681012266 Major Facilitator Superfamily; Region: MFS_1; pfam07690 358681012267 putative substrate translocation pore; other site 358681012268 3'-5' exoribonuclease YhaM; Provisional; Region: PRK13480 358681012269 YhaM_OBF_like: A subfamily of OB folds similar to that found in Bacillus subtilis YhaM and Staphylococcus aureus cmp-binding factor-1 (SaCBF1). Both these proteins are 3'-to-5'exoribonucleases. YhaM requires Mn2+ or Co2+ for activity and is...; Region: YhaM_OBF_like; cd04492 358681012270 generic binding surface I; other site 358681012271 generic binding surface II; other site 358681012272 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 358681012273 Zn2+ binding site [ion binding]; other site 358681012274 Mg2+ binding site [ion binding]; other site 358681012275 Uncharacterized conserved protein [Function unknown]; Region: COG3339 358681012276 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 358681012277 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 358681012278 Uncharacterized protein conserved in bacteria (DUF2062); Region: DUF2062; pfam09835 358681012279 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 358681012280 NAD synthase [Coenzyme metabolism]; Region: NadE; COG0171 358681012281 NAD+ synthase is a homodimer, which catalyzes the final step in de novo nicotinamide adenine dinucleotide (NAD+) biosynthesis, an amide transfer from either ammonia or glutamine to nicotinic acid adenine dinucleotide (NaAD). The conversion of NaAD to NAD...; Region: NAD_synthase; cd00553 358681012282 homodimer interface [polypeptide binding]; other site 358681012283 NAD binding pocket [chemical binding]; other site 358681012284 ATP binding pocket [chemical binding]; other site 358681012285 Mg binding site [ion binding]; other site 358681012286 active-site loop [active] 358681012287 Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086 358681012288 active site 358681012289 luciferase family oxidoreductase, group 1; Region: oxido_grp_1; TIGR03558 358681012290 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 358681012291 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cd00347 358681012292 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 358681012293 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 358681012294 PspC domain; Region: PspC; pfam04024 358681012295 Conserved protein/domain typically associated with flavoprotein oxygenases, DIM6/NTAB family [General function prediction only]; Region: COG1853 358681012296 homogentisate 1,2-dioxygenase; Region: HgmA; cl17306 358681012297 2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179 358681012298 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557 358681012299 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 358681012300 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 358681012301 active site 358681012302 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 358681012303 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 358681012304 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 358681012305 WHG domain; Region: WHG; pfam13305 358681012306 Peroxiredoxin (PRX) family, Atypical 2-cys PRX subfamily; composed of PRXs containing peroxidatic and resolving cysteines, similar to the homodimeric thiol specific antioxidant (TSA) protein also known as TRX-dependent thiol peroxidase (Tpx). Tpx is a...; Region: PRX_Atyp2cys; cd03014 358681012307 dimer interface [polypeptide binding]; other site 358681012308 catalytic triad [active] 358681012309 peroxidatic and resolving cysteines [active] 358681012310 GGCT-like domains, also called AIG2-like family. Gamma-glutamyl cyclotransferase (GGCT) catalyzes the formation of pyroglutamic acid (5-oxoproline) from dipeptides containing gamma-glutamyl, and is a dimeric protein. In Homo sapiens, the protein is...; Region: GGCT_like; cd06661 358681012311 putative active site pocket [active] 358681012312 dimerization interface [polypeptide binding]; other site 358681012313 putative catalytic residue [active] 358681012314 pyruvate carboxylase; Reviewed; Region: PRK12999 358681012315 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 358681012316 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786 358681012317 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 358681012318 Pyruvate carboxylase and Transcarboxylase 5S, carboxyltransferase domain; Region: DRE_TIM_PC_TC_5S; cd07937 358681012319 active site 358681012320 catalytic residues [active] 358681012321 metal binding site [ion binding]; metal-binding site 358681012322 homodimer binding site [polypeptide binding]; other site 358681012323 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 358681012324 carboxyltransferase (CT) interaction site; other site 358681012325 biotinylation site [posttranslational modification]; other site 358681012326 sporulation protein YtfJ; Region: spore_ytfJ; TIGR02874 358681012327 Protein of unknown function (DUF2953); Region: DUF2953; pfam11167 358681012328 S-layer homology domain; Region: SLH; pfam00395 358681012329 S-layer homology domain; Region: SLH; pfam00395 358681012330 3D domain; Region: 3D; cl01439 358681012331 spore cortex-lytic enzyme; Region: spore_SleB; TIGR02869 358681012332 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 358681012333 Cell Wall Hydrolase; Region: Hydrolase_2; pfam07486 358681012334 stage V sporulation protein AE; Region: spore_V_AE; TIGR02839 358681012335 stage V sporulation protein AD; Provisional; Region: PRK12404 358681012336 Stage V sporulation protein AD (SpoVAD); Region: SpoVAD; pfam07451 358681012337 SpoVA protein; Region: SpoVA; cl04298 358681012338 Predicted membrane protein [Function unknown]; Region: COG2323 358681012339 Protein of unknown function (DUF1657); Region: DUF1657; pfam07870 358681012340 Protein of unknown function (DUF1657); Region: DUF1657; pfam07870 358681012341 Small, acid-soluble spore proteins, alpha/beta type; Region: SASP; pfam00269 358681012342 diacylglycerol glucosyltransferase; Provisional; Region: PRK13609 358681012343 Monogalactosyldiacylglycerol (MGDG) synthase; Region: MGDG_synth; pfam06925 358681012344 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 358681012345 integral membrane protein, YjbE family; Region: R_switched_YjbE; TIGR03717 358681012346 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 358681012347 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 358681012348 dimer interface [polypeptide binding]; other site 358681012349 phosphorylation site [posttranslational modification] 358681012350 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 358681012351 ATP binding site [chemical binding]; other site 358681012352 Mg2+ binding site [ion binding]; other site 358681012353 G-X-G motif; other site 358681012354 Domain of unknown function (DUF2437); Region: DUF2437; pfam10370 358681012355 2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179 358681012356 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557 358681012357 thiamine biosynthesis protein ThiI; Provisional; Region: PRK01565 358681012358 THUMP domain of thiamine biosynthesis protein ThiI; Region: THUMP_ThiI; cd11716 358681012359 ThiI is required for thiazole synthesis in the thiamine biosynthesis pathway. It belongs to the Adenosine Nucleotide Hydrolysis suoerfamily and predicted to bind to Adenosine nucleotide; Region: ThiI; cd01712 358681012360 Ligand Binding Site [chemical binding]; other site 358681012361 Cysteine sulfinate desulfinase/cysteine desulfurase and related enzymes [Amino acid transport and metabolism]; Region: NifS; COG1104 358681012362 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 358681012363 catalytic residue [active] 358681012364 diaminopimelate epimerase; Provisional; Region: dapF; PRK00450 358681012365 Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678 358681012366 Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678 358681012367 Protein of unknown function DUF84; Region: NTPase_I-T; cl00866 358681012368 Protein of unknown function (DUF3816); Region: DUF3816; pfam12822 358681012369 Domain of unknown function (DUF4190); Region: DUF4190; pfam13828 358681012370 Uncharacterized conserved protein [Function unknown]; Region: COG5663 358681012371 Domain of Unknown Function (DUF1540); Region: DUF1540; pfam07561 358681012372 Short-chain alcohol dehydrogenase of unknown specificity [General function prediction only]; Region: COG4221 358681012373 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 358681012374 NAD(P) binding site [chemical binding]; other site 358681012375 active site 358681012376 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 358681012377 H+ Antiporter protein; Region: 2A0121; TIGR00900 358681012378 putative substrate translocation pore; other site 358681012379 H+ Antiporter protein; Region: 2A0121; TIGR00900 358681012380 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 358681012381 putative substrate translocation pore; other site 358681012382 Predicted transcriptional regulators [Transcription]; Region: COG1777 358681012383 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 358681012384 dimerization interface [polypeptide binding]; other site 358681012385 putative DNA binding site [nucleotide binding]; other site 358681012386 putative Zn2+ binding site [ion binding]; other site 358681012387 H+ Antiporter protein; Region: 2A0121; TIGR00900 358681012388 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 358681012389 putative substrate translocation pore; other site 358681012390 Beta-lactamase; Region: Beta-lactamase; pfam00144 358681012391 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 358681012392 Domain of unknown function (DUF3471); Region: DUF3471; pfam11954 358681012393 N-acylamino acid racemase (NAAAR), an octameric enzyme that catalyzes the racemization of N-acylamino acids. NAAARs act on a broad range of N-acylamino acids rather than amino acids. Enantiopure amino acids are of industrial interest as chiral building...; Region: NAAAR; cd03317 358681012394 o-succinylbenzoate synthase; Region: menC_lowGC/arch; TIGR01928 358681012395 active site 358681012396 octamer interface [polypeptide binding]; other site 358681012397 dipeptide transporter ATP-binding subunit; Provisional; Region: dppF; PRK11308 358681012398 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 358681012399 Walker A/P-loop; other site 358681012400 ATP binding site [chemical binding]; other site 358681012401 Q-loop/lid; other site 358681012402 ABC transporter signature motif; other site 358681012403 Walker B; other site 358681012404 D-loop; other site 358681012405 H-loop/switch region; other site 358681012406 oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727 358681012407 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 358681012408 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 358681012409 Walker A/P-loop; other site 358681012410 ATP binding site [chemical binding]; other site 358681012411 Q-loop/lid; other site 358681012412 ABC transporter signature motif; other site 358681012413 Walker B; other site 358681012414 D-loop; other site 358681012415 H-loop/switch region; other site 358681012416 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 358681012417 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 358681012418 N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911 358681012419 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 358681012420 dimer interface [polypeptide binding]; other site 358681012421 conserved gate region; other site 358681012422 ABC-ATPase subunit interface; other site 358681012423 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 358681012424 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 358681012425 dimer interface [polypeptide binding]; other site 358681012426 conserved gate region; other site 358681012427 putative PBP binding loops; other site 358681012428 ABC-ATPase subunit interface; other site 358681012429 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 358681012430 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_15; cd08492 358681012431 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 358681012432 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 358681012433 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 358681012434 putative active site [active] 358681012435 Uncharacterized conserved protein [Function unknown]; Region: COG5476 358681012436 Protein of unknown function (DUF1485); Region: DUF1485; pfam07364 358681012437 MlrC C-terminus; Region: MlrC_C; pfam07171 358681012438 transcriptional repressor CodY; Validated; Region: PRK04158 358681012439 CodY GAF-like domain; Region: CodY; pfam06018 358681012440 CodY helix-turn-helix domain; Region: HTH_CodY; pfam08222 358681012441 Sporulation control protein [General function prediction only]; Region: Spo0M; COG4326 358681012442 SpoOM protein; Region: Spo0M; pfam07070 358681012443 Sporulation protein YtrH; Region: Spore_YtrH; pfam14034 358681012444 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 358681012445 Major Facilitator Superfamily; Region: MFS_1; pfam07690 358681012446 putative substrate translocation pore; other site 358681012447 M42 Peptidase, Endoglucanases; Region: M42_Frv; cd05656 358681012448 Cellulase M and related proteins [Carbohydrate transport and metabolism]; Region: FrvX; COG1363 358681012449 oligomer interface [polypeptide binding]; other site 358681012450 active site 358681012451 metal binding site [ion binding]; metal-binding site 358681012452 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 358681012453 Coenzyme A binding pocket [chemical binding]; other site 358681012454 Anaerobic glycerol-3-phosphate dehydrogenase [Amino acid transport and metabolism]; Region: GlpB; cl17730 358681012455 HI0933-like protein; Region: HI0933_like; pfam03486 358681012456 Repair protein; Region: Repair_PSII; cl01535 358681012457 septation ring formation regulator EzrA; Provisional; Region: PRK04778 358681012458 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 358681012459 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 358681012460 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 358681012461 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 358681012462 GAF domain; Region: GAF_3; pfam13492 358681012463 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 358681012464 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 358681012465 metal binding site [ion binding]; metal-binding site 358681012466 active site 358681012467 I-site; other site 358681012468 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 358681012469 catalytic core [active] 358681012470 S-layer homology domain; Region: SLH; pfam00395 358681012471 30S ribosomal protein S4; Validated; Region: rpsD; PRK05327 358681012472 Ribosomal protein S4/S9 N-terminal domain; Region: Ribosomal_S4; pfam00163 358681012473 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 358681012474 RNA binding surface [nucleotide binding]; other site 358681012475 Uncharacterized protein family (UPF0157); Region: UPF0157; cl00987 358681012476 Transglycosylase; Region: Transgly; pfam00912 358681012477 penicillin-binding protein, 1A family; Region: PBP_1a_fam; TIGR02074 358681012478 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 358681012479 FOG: CBS domain [General function prediction only]; Region: COG0517 358681012480 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in the acetoin utilization proteins in bacteria. Acetoin is a product of fermentative metabolism in many prokaryotic and eukaryotic microorganisms. They produce...; Region: CBS_pair_ACT_assoc; cd04584 358681012481 ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141 358681012482 Deacetylases, including yeast histone deacetylase and acetoin utilization protein [Chromatin structure and dynamics / Secondary metabolites biosynthesis, transport, and catabolism]; Region: AcuC; COG0123 358681012483 Class I histone deacetylase AcuC (Acetoin utilization protein)-like enzymes; Region: HDAC_AcuC_like; cd09994 358681012484 active site 358681012485 Zn binding site [ion binding]; other site 358681012486 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase; Validated; Region: PRK05584 358681012487 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase; Region: MTA/SAH-Nsdase; TIGR01704 358681012488 NrdH-redoxin (NrdH) family; NrdH is a small monomeric protein with a conserved redox active CXXC motif within a TRX fold, characterized by a glutaredoxin (GRX)-like sequence and TRX-like activity profile. In vitro, it displays protein disulfide reductase...; Region: NrdH; cd02976 358681012489 catalytic residues [active] 358681012490 catabolite control protein A; Region: ccpA; TIGR01481 358681012491 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 358681012492 DNA binding site [nucleotide binding] 358681012493 domain linker motif; other site 358681012494 Ligand-binding domain of the catabolite control protein A (CcpA), which functions as the major transcriptional regulator of carbon catabolite repression/regulation; Region: PBP1_CcpA_like; cd06298 358681012495 dimerization interface [polypeptide binding]; other site 358681012496 effector binding site; other site 358681012497 Staphylococcus aureus copper-sensitive operon repressor (CsoR), and related domains; this family was previously known as part of DUF156; Region: SaCsoR-like_DUF156; cd10152 358681012498 putative homodimer interface [polypeptide binding]; other site 358681012499 putative homotetramer interface [polypeptide binding]; other site 358681012500 allosteric switch controlling residues; other site 358681012501 putative metal binding site [ion binding]; other site 358681012502 putative homodimer-homodimer interface [polypeptide binding]; other site 358681012503 bifunctional 3-deoxy-7-phosphoheptulonate synthase/chorismate mutase; Reviewed; Region: PRK12595 358681012504 Chorismate mutase type II; Region: CM_2; cl00693 358681012505 phospho-2-dehydro-3-deoxyheptonate aldolase; Region: DAHP_synth_Bsub; TIGR01361 358681012506 Cell division protein FtsA; Region: FtsA; smart00842 358681012507 type IV pilus assembly protein PilM; Region: pilM; TIGR01175 358681012508 Cell division protein FtsA; Region: FtsA; pfam14450 358681012509 bacillithiol system protein YtxJ; Region: B_thiol_YtxJ; TIGR04019 358681012510 Thermophilic metalloprotease (M29); Region: Peptidase_M29; pfam02073 358681012511 Leucyl aminopeptidase (aminopeptidase T) [Amino acid transport and metabolism]; Region: AmpS; COG2309 358681012512 Predicted transcriptional regulators [Transcription]; Region: COG1695 358681012513 Transcriptional regulator PadR-like family; Region: PadR; pfam03551 358681012514 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 358681012515 YheC/D like ATP-grasp; Region: ATPgrasp_YheCD; pfam14398 358681012516 Predicted transcriptional regulators [Transcription]; Region: COG1733 358681012517 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 358681012518 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961 358681012519 Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cd00338 358681012520 catalytic residues [active] 358681012521 catalytic nucleophile [active] 358681012522 Recombinase; Region: Recombinase; pfam07508 358681012523 Recombinase zinc beta ribbon domain; Region: Zn_ribbon_recom; pfam13408 358681012524 Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad...; Region: Tryp_SPc; cl00149 358681012525 Uncharacterized protein conserved in bacteria (DUF2325); Region: DUF2325; cl01811 358681012526 Encapsulating protein for peroxidase; Region: Linocin_M18; pfam04454 358681012527 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 358681012528 Aspartate/tyrosine/aromatic aminotransferase [Amino acid transport and metabolism]; Region: COG0436 358681012529 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 358681012530 pyridoxal 5'-phosphate binding site [chemical binding]; other site 358681012531 homodimer interface [polypeptide binding]; other site 358681012532 catalytic residue [active] 358681012533 transaminase; Reviewed; Region: PRK08068 358681012534 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 358681012535 pyridoxal 5'-phosphate binding site [chemical binding]; other site 358681012536 homodimer interface [polypeptide binding]; other site 358681012537 catalytic residue [active] 358681012538 Major Facilitator Superfamily; Region: MFS_1; pfam07690 358681012539 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 358681012540 MoaC family, prokaryotic and eukaryotic. Members of this family are involved in molybdenum cofactor (Moco) biosynthesis, an essential cofactor of a diverse group of redox enzymes. MoaC, a small hexameric protein, converts, together with MoaA, a guanosine...; Region: MoaC_PE; cd01420 358681012541 trimer interface [polypeptide binding]; other site 358681012542 dimer interface [polypeptide binding]; other site 358681012543 putative active site [active] 358681012544 Methylated DNA-protein cysteine methyltransferase [DNA replication, recombination, and repair]; Region: Ada; COG0350 358681012545 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 358681012546 DNA binding site [nucleotide binding] 358681012547 active site 358681012548 Uncharacterized protein conserved in bacteria (DUF2086); Region: DUF2086; pfam09859 358681012549 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 358681012550 Radical SAM superfamily; Region: Radical_SAM; pfam04055 358681012551 FeS/SAM binding site; other site 358681012552 Ubiquitin domain of MoaD-like proteins; Region: MoaD; cd00754 358681012553 MoaE interaction surface [polypeptide binding]; other site 358681012554 MoeB interaction surface [polypeptide binding]; other site 358681012555 thiocarboxylated glycine; other site 358681012556 MoaE family. Members of this family are involved in biosynthesis of the molybdenum cofactor (Moco), an essential cofactor for a diverse group of redox enzymes. Moco biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoaE; cd00756 358681012557 MoaE homodimer interface [polypeptide binding]; other site 358681012558 MoaD interaction [polypeptide binding]; other site 358681012559 active site residues [active] 358681012560 thiamine/molybdopterin biosynthesis ThiF/MoeB-like protein; Validated; Region: PRK07688 358681012561 ThiF_MoeB_HesA. Family of E1-like enzymes involved in molybdopterin and thiamine biosynthesis family. The common reaction mechanism catalyzed by MoeB and ThiF, like other E1 enzymes, begins with a nucleophilic attack of the C-terminal carboxylate of MoaD...; Region: ThiF_MoeB_HesA_family; cd00757 358681012562 ATP binding site [chemical binding]; other site 358681012563 substrate interface [chemical binding]; other site 358681012564 HAMP domain; Region: HAMP; pfam00672 358681012565 dimerization interface [polypeptide binding]; other site 358681012566 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 358681012567 dimer interface [polypeptide binding]; other site 358681012568 phosphorylation site [posttranslational modification] 358681012569 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 358681012570 ATP binding site [chemical binding]; other site 358681012571 Mg2+ binding site [ion binding]; other site 358681012572 G-X-G motif; other site 358681012573 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 358681012574 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 358681012575 active site 358681012576 phosphorylation site [posttranslational modification] 358681012577 intermolecular recognition site; other site 358681012578 dimerization interface [polypeptide binding]; other site 358681012579 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 358681012580 DNA binding site [nucleotide binding] 358681012581 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 358681012582 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 358681012583 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 358681012584 Walker A/P-loop; other site 358681012585 ATP binding site [chemical binding]; other site 358681012586 Q-loop/lid; other site 358681012587 ABC transporter signature motif; other site 358681012588 Walker B; other site 358681012589 D-loop; other site 358681012590 H-loop/switch region; other site 358681012591 aconitate hydratase; Validated; Region: PRK09277 358681012592 Aconitase A catalytic domain; Region: AcnA_IRP; cd01586 358681012593 substrate binding site [chemical binding]; other site 358681012594 ligand binding site [chemical binding]; other site 358681012595 Aconitase A swivel domain. This is the major form of the TCA cycle enzyme aconitate hydratase, also known as aconitase and citrate hydro-lyase. It includes bacterial and archaeal aconitase A, and the eukaryotic cytosolic form of aconitase. This group...; Region: AcnA_IRP_Swivel; cd01580 358681012596 substrate binding site [chemical binding]; other site 358681012597 alanine racemase; Region: alr; TIGR00492 358681012598 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Alanine Racemase; Region: PLPDE_III_AR; cd00430 358681012599 active site 358681012600 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 358681012601 dimer interface [polypeptide binding]; other site 358681012602 substrate binding site [chemical binding]; other site 358681012603 catalytic residues [active] 358681012604 Protein of unknown function (DUF3892); Region: DUF3892; pfam13031 358681012605 Domain of unknown function (DUF4188); Region: DUF4188; pfam13826 358681012606 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 358681012607 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 358681012608 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 358681012609 MarR family; Region: MarR; pfam01047 358681012610 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 358681012611 Major Facilitator Superfamily; Region: MFS_1; pfam07690 358681012612 putative substrate translocation pore; other site 358681012613 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 358681012614 helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346 358681012615 Transcriptional regulator [Transcription]; Region: IclR; COG1414 358681012616 Bacterial transcriptional regulator; Region: IclR; pfam01614 358681012617 YheC/D like ATP-grasp; Region: ATPgrasp_YheCD; pfam14398 358681012618 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 358681012619 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 358681012620 active site 358681012621 catalytic tetrad [active] 358681012622 phage tail protein domain; Region: tail_TIGR02242 358681012623 conserved hypothetical protein, phage tail-like region; Region: TIGR02243 358681012624 conserved hypothetical protein, phage tail-like region; Region: TIGR02243 358681012625 conserved hypothetical protein, phage tail-like region; Region: TIGR02243 358681012626 conserved hypothetical protein, phage tail-like region; Region: TIGR02243 358681012627 Gene 25-like lysozyme; Region: GPW_gp25; pfam04965 358681012628 Phage-related baseplate assembly protein; Region: Phage_base_V; pfam04717 358681012629 Phage protein D [General function prediction only]; Region: COG3500 358681012630 Uncharacterized protein containing LysM domain [Function unknown]; Region: XkdP; COG1652 358681012631 T4-like virus tail tube protein gp19; Region: Phage_T4_gp19; pfam06841 358681012632 T4-like virus tail tube protein gp19; Region: Phage_T4_gp19; pfam06841 358681012633 Phage tail sheath protein; Region: Phage_sheath_1; cl01389 358681012634 Phage tail sheath protein FI [General function prediction only]; Region: COG3497 358681012635 Protein of unknown function (DUF4255); Region: DUF4255; pfam14065 358681012636 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 358681012637 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 358681012638 Walker A motif; other site 358681012639 ATP binding site [chemical binding]; other site 358681012640 Walker B motif; other site 358681012641 arginine finger; other site 358681012642 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 358681012643 dimerization interface [polypeptide binding]; other site 358681012644 Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114 358681012645 cyclase homology domain; Region: CHD; cd07302 358681012646 nucleotidyl binding site; other site 358681012647 metal binding site [ion binding]; metal-binding site 358681012648 dimer interface [polypeptide binding]; other site 358681012649 Domain of unknown function (DUF4280); Region: DUF4280; pfam14107 358681012650 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4642 358681012651 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4642 358681012652 Domain of unknown function (DUF4157); Region: DUF4157; pfam13699 358681012653 PPOX class probable FMN-dependent enzyme, DR_2398 family; Region: PPOX_FMN_DR2398; TIGR04025 358681012654 Rotavirus RNA-binding Protein 53 (NS53); Region: Rota_NS53; pfam00981 358681012655 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3314 358681012656 Nucleoside recognition; Region: Gate; pfam07670 358681012657 imidazolonepropionase; Validated; Region: PRK09356 358681012658 Imidazolonepropionase/imidazolone-5-propionate hydrolase (Imidazolone-5PH) catalyzes the third step in the histidine degradation pathway, the hydrolysis of (S)-3-(5-oxo-4,5-dihydro-3H-imidazol-4-yl)propanoate to N-formimidoyl-L-glutamate. In bacteria; Region: Imidazolone-5PH; cd01296 358681012659 active site 358681012660 urocanate hydratase; Provisional; Region: PRK05414 358681012661 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 358681012662 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 358681012663 signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227 358681012664 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 358681012665 Catalytic site [active] 358681012666 Transcriptional regulator containing PAS, AAA-type ATPase, and DNA-binding domains [Transcription / Signal transduction mechanisms]; Region: RocR; COG3829 358681012667 PAS domain; Region: PAS; smart00091 358681012668 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 358681012669 Walker A motif; other site 358681012670 ATP binding site [chemical binding]; other site 358681012671 Walker B motif; other site 358681012672 arginine finger; other site 358681012673 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 358681012674 M20 Peptidases with similarity to acetylornithine deacetylases and succinyl-diaminopimelate desuccinylases; Region: M20_ArgE_DapE_like3; cd08013 358681012675 succinyl-diaminopimelate desuccinylase; Reviewed; Region: PRK08651 358681012676 metal binding site [ion binding]; metal-binding site 358681012677 putative dimer interface [polypeptide binding]; other site 358681012678 diaminopropionate ammonia-lyase; Provisional; Region: PRK08206 358681012679 Pyridoxal-phosphate dependent enzyme; Region: PALP; pfam00291 358681012680 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 358681012681 catalytic residue [active] 358681012682 Penicillinase repressor; Region: Pencillinase_R; pfam03965 358681012683 BlaR1 peptidase M56; Region: Peptidase_M56; pfam05569 358681012684 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 358681012685 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 358681012686 active site 358681012687 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 358681012688 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 358681012689 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 358681012690 DNA binding residues [nucleotide binding] 358681012691 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 358681012692 23S rRNA methyltransferase A; Provisional; Region: rrmA; PRK11088 358681012693 Methyltransferase domain; Region: Methyltransf_11; pfam08241 358681012694 S-adenosylmethionine binding site [chemical binding]; other site 358681012695 carbamoyl phosphate synthase-like protein; Provisional; Region: PRK12767 358681012696 ATP-grasp domain; Region: ATP-grasp_4; pfam13535 358681012697 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes; Region: PLPDE_III; cl00261 358681012698 Diaminopimelate decarboxylase [Amino acid transport and metabolism]; Region: LysA; COG0019 358681012699 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 358681012700 catalytic residue [active] 358681012701 aminotransferase, LLPSF_NHT_00031 family; Region: NHT_00031; TIGR04181 358681012702 3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616 358681012703 inhibitor-cofactor binding pocket; inhibition site 358681012704 pyridoxal 5'-phosphate binding site [chemical binding]; other site 358681012705 catalytic residue [active] 358681012706 Acetyltransferase (GNAT) domain; Region: Acetyltransf_6; pfam13480 358681012707 Bacterial sugar transferase; Region: Bac_transf; pfam02397 358681012708 Putative catalytic domain of uncharacterized bacterial proteins from the carbohydrate esterase 4 superfamily; Region: CE4_u5; cd10929 358681012709 putative active site [active] 358681012710 This family is most closely related to the GT1 family of glycosyltransferases. cap1E in Streptococcus pneumoniae is required for the synthesis of type 1 capsular polysaccharides; Region: GT1_cap1E_like; cd03808 358681012711 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 358681012712 putative ADP-binding pocket [chemical binding]; other site 358681012713 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis/translation initiation factor 2B, gamma/epsilon subunits (eIF-2Bgamma/eIF-2Bepsilon) [Cell envelope biogenesis, outer membrane / Translation, ribosomal structure...; Region: GCD1; COG1208 358681012714 Phosphocholine cytidylyltransferases catalyze the synthesis of CDP-choline; Region: PC_cytidylyltransferase; cd02523 358681012715 active site 358681012716 metal-binding site 358681012717 CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; pfam01066 358681012718 Wzx, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_Wzx_like; cd13128 358681012719 Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244 358681012720 capsular exopolysaccharide family; Region: eps_fam; TIGR01007 358681012721 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 358681012722 Chain length determinant protein; Region: Wzz; cl15801 358681012723 Cell envelope-related transcriptional attenuator domain; Region: LytR_cpsA_psr; cl00581 358681012724 Predicted nucleoside-diphosphate sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG1086 358681012725 UDP-Glcnac (UDP-linked N-acetylglucosamine) inverting 4,6-dehydratase, extended (e) SDRs; Region: UDP_invert_4-6DH_SDR_e; cd05237 358681012726 NAD(P) binding site [chemical binding]; other site 358681012727 homodimer interface [polypeptide binding]; other site 358681012728 substrate binding site [chemical binding]; other site 358681012729 active site 358681012730 Vi polysaccharide biosynthesis protein TviB; Provisional; Region: PRK15182 358681012731 UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984 358681012732 UDP binding domain; Region: UDPG_MGDP_dh_C; smart00984 358681012733 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 358681012734 UDP glucuronic acid epimerase, extended (e) SDRs; Region: UDP_GE_SDE_e; cd05253 358681012735 putative NAD(P) binding site [chemical binding]; other site 358681012736 active site 358681012737 putative substrate binding site [chemical binding]; other site 358681012738 Pectate lyase superfamily protein; Region: Pectate_lyase_3; pfam12708 358681012739 DNA segregation ATPase FtsK/SpoIIIE and related proteins [Cell division and chromosome partitioning]; Region: FtsK; COG1674 358681012740 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 358681012741 Ftsk gamma domain; Region: Ftsk_gamma; pfam09397 358681012742 Adenosine 5'-phosphosulfate kinase (APSK) catalyzes the phosphorylation of adenosine 5'-phosphosulfate to form 3'-phosphoadenosine 5'-phosphosulfate (PAPS). The end-product PAPS is a biologically "activated" sulfate form...; Region: APSK; cd02027 358681012743 ligand-binding site [chemical binding]; other site 358681012744 sulfate adenylyltransferase; Reviewed; Region: sat; PRK04149 358681012745 ATP-sulfurylase; Region: ATPS; cd00517 358681012746 active site 358681012747 HXXH motif; other site 358681012748 flexible loop; other site 358681012749 3'-phosphoadenosine 5'-phosphosulfate sulfotransferase (PAPS reductase)/FAD synthetase and related enzymes [Amino acid transport and metabolism / Coenzyme metabolism]; Region: CysH; COG0175 358681012750 This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713 358681012751 Active Sites [active] 358681012752 Uroporphyrin-III C-methyltransferase (S-Adenosyl-L-methionine:uroporphyrinogen III methyltransferase, SUMT); Region: SUMT; cd11642 358681012753 active site 358681012754 SAM binding site [chemical binding]; other site 358681012755 homodimer interface [polypeptide binding]; other site 358681012756 Uroporphyrinogen-III synthase [Coenzyme metabolism]; Region: HemD; COG1587 358681012757 Uroporphyrinogen-III synthase (HemD) catalyzes the asymmetrical cyclization of tetrapyrrole (linear) to uroporphyrinogen-III, the fourth step in the biosynthesis of heme. This ubiquitous enzyme is present in eukaryotes, bacteria and archaea. Mutations in...; Region: HemD; cd06578 358681012758 active site 358681012759 Sirohydrochlorin ferrochelatase [Inorganic ion transport and metabolism]; Region: COG2138 358681012760 Sirohydrochlorin cobalt chelatase (CbiX) and sirohydrochlorin iron chelatase (SirB), N-terminal domain. SirB catalyzes the ferro-chelation of sirohydrochlorin to siroheme, the prosthetic group of sulfite and nitrite reductases. CbiX is a cobaltochelatase; Region: CbiX_SirB_N; cd03416 358681012761 putative active site [active] 358681012762 Sirohydrochlorin cobalt chelatase (CbiX) and sirohydrochlorin iron chelatase (SirB), N-terminal domain. SirB catalyzes the ferro-chelation of sirohydrochlorin to siroheme, the prosthetic group of sulfite and nitrite reductases. CbiX is a cobaltochelatase; Region: CbiX_SirB_N; cd03416 358681012763 putative active site [active] 358681012764 Ion transport protein; Region: Ion_trans; pfam00520 358681012765 Ion channel; Region: Ion_trans_2; pfam07885 358681012766 Predicted membrane protein [Function unknown]; Region: COG3766 358681012767 Domain of Unknown Function (DUF350); Region: DUF350; pfam03994 358681012768 Glutathionylspermidine synthase preATP-grasp; Region: GSP_synth; cl00503 358681012769 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483 358681012770 IMPase, inositol monophosphatase and related domains. A family of Mg++ dependent phosphatases, inhibited by lithium, many of which may act on inositol monophosphate substrate. They dephosphorylate inositol phosphate to generate inositol, which may be...; Region: IMPase; cd01639 358681012771 active site 358681012772 dimerization interface [polypeptide binding]; other site 358681012773 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 358681012774 CoenzymeA binding site [chemical binding]; other site 358681012775 subunit interaction site [polypeptide binding]; other site 358681012776 PHB binding site; other site 358681012777 dihydroxy-acid dehydratase; Provisional; Region: PRK00911 358681012778 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 358681012779 dimerization interface [polypeptide binding]; other site 358681012780 putative DNA binding site [nucleotide binding]; other site 358681012781 putative Zn2+ binding site [ion binding]; other site 358681012782 H+ Antiporter protein; Region: 2A0121; TIGR00900 358681012783 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 358681012784 putative substrate translocation pore; other site 358681012785 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 358681012786 NlpC/P60 family; Region: NLPC_P60; pfam00877 358681012787 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 358681012788 S-adenosylmethionine binding site [chemical binding]; other site 358681012789 Response regulator of citrate/malate metabolism [Transcription / Signal transduction mechanisms]; Region: CitB; COG4565 358681012790 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 358681012791 active site 358681012792 phosphorylation site [posttranslational modification] 358681012793 intermolecular recognition site; other site 358681012794 dimerization interface [polypeptide binding]; other site 358681012795 Bacterial protein of unknown function (DUF977); Region: DUF977; pfam06163 358681012796 Signal transduction histidine kinase regulating citrate/malate metabolism [Signal transduction mechanisms]; Region: CitA; COG3290 358681012797 PAS domain; Region: PAS; smart00091 358681012798 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 358681012799 ATP binding site [chemical binding]; other site 358681012800 Mg2+ binding site [ion binding]; other site 358681012801 G-X-G motif; other site 358681012802 H+/citrate symporter [Energy production and conversion]; Region: CitM; cl17620 358681012803 Citrate transporter; Region: CitMHS; pfam03600 358681012804 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 358681012805 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 358681012806 active site 358681012807 ABC-2 family transporter protein; Region: ABC2_membrane_2; cl17866 358681012808 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 358681012809 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 358681012810 Walker A/P-loop; other site 358681012811 ATP binding site [chemical binding]; other site 358681012812 Q-loop/lid; other site 358681012813 ABC transporter signature motif; other site 358681012814 Walker B; other site 358681012815 D-loop; other site 358681012816 H-loop/switch region; other site 358681012817 Putative zinc-finger; Region: zf-HC2; pfam13490 358681012818 RNA polymerase sigma factor SigX; Provisional; Region: PRK09639 358681012819 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 358681012820 Predicted ATPase [General function prediction only]; Region: COG3910 358681012821 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 358681012822 Walker A/P-loop; other site 358681012823 ATP binding site [chemical binding]; other site 358681012824 Q-loop/lid; other site 358681012825 ABC transporter signature motif; other site 358681012826 Walker B; other site 358681012827 D-loop; other site 358681012828 H-loop/switch region; other site 358681012829 potential protein location (hypothetical protein) that overlaps protein (hypothetical protein) 358681012830 potential protein location (hypothetical protein) that overlaps protein (hypothetical protein) 358681012831 Peptidase family M9 N-terminal; Region: Peptidase_M9_N; pfam08453 358681012832 Peptidase Gluzincin family (thermolysin-like proteinases, TLPs) includes peptidases M1, M2, M3, M4, M13, M32 and M36 (fungalysins); Region: GluZincin; cl14813 358681012833 polycystic kidney disease I (PKD) domain; similar to other cell-surface modules, with an IG-like fold; domain probably functions as a ligand binding site in protein-protein or protein-carbohydrate interactions; a single instance of the repeat is...; Region: PKD; cd00146 358681012834 Bacterial pre-peptidase C-terminal domain; Region: PPC; pfam04151 358681012835 Bacterial pre-peptidase C-terminal domain; Region: PPC; pfam04151 358681012836 Transglycosylase; Region: Transgly; pfam00912 358681012837 penicillin-binding protein, 1A family; Region: PBP_1a_fam; TIGR02074 358681012838 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 358681012839 Transketolase [Carbohydrate transport and metabolism]; Region: TktA; COG0021 358681012840 Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012 358681012841 TPP-binding site [chemical binding]; other site 358681012842 dimer interface [polypeptide binding]; other site 358681012843 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 358681012844 PYR/PP interface [polypeptide binding]; other site 358681012845 dimer interface [polypeptide binding]; other site 358681012846 TPP binding site [chemical binding]; other site 358681012847 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 358681012848 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_24; cd04683 358681012849 nudix motif; other site 358681012850 Glycerol kinase [Energy production and conversion]; Region: GlpK; COG0554 358681012851 Glycerol kinases; a subfamily of the FGGY family of carbohydrate kinases; Region: FGGY_GK; cd07769 358681012852 N- and C-terminal domain interface [polypeptide binding]; other site 358681012853 active site 358681012854 MgATP binding site [chemical binding]; other site 358681012855 catalytic site [active] 358681012856 metal binding site [ion binding]; metal-binding site 358681012857 glycerol binding site [chemical binding]; other site 358681012858 homotetramer interface [polypeptide binding]; other site 358681012859 homodimer interface [polypeptide binding]; other site 358681012860 permease, urea carboxylase system; Region: ureacarb_perm; TIGR03428 358681012861 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 358681012862 helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420 358681012863 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 358681012864 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643 358681012865 hydrophobic ligand binding site; other site 358681012866 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_2; pfam07992 358681012867 Predicted dehydrogenase [General function prediction only]; Region: COG0579 358681012868 hydroxyglutarate oxidase; Provisional; Region: PRK11728 358681012869 BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324 358681012870 Cache domain; Region: Cache_1; pfam02743 358681012871 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 358681012872 dimerization interface [polypeptide binding]; other site 358681012873 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 358681012874 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 358681012875 dimer interface [polypeptide binding]; other site 358681012876 putative CheW interface [polypeptide binding]; other site 358681012877 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 358681012878 Bacterial protein of unknown function (DUF910); Region: DUF910; cl11543 358681012879 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 358681012880 Major Facilitator Superfamily; Region: MFS_1; pfam07690 358681012881 putative substrate translocation pore; other site 358681012882 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 358681012883 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 358681012884 Walker A/P-loop; other site 358681012885 ATP binding site [chemical binding]; other site 358681012886 Q-loop/lid; other site 358681012887 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 358681012888 ABC transporter; Region: ABC_tran_2; pfam12848 358681012889 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 358681012890 Copper amine oxidase N-terminal domain; Region: Cu_amine_oxidN1; pfam07833 358681012891 PrcB C-terminal; Region: PrcB_C; pfam14343 358681012892 Predicted permeases [General function prediction only]; Region: COG0679 358681012893 Immunity protein Imm1; Region: Imm1; pfam14430 358681012894 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 358681012895 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 358681012896 substrate binding pocket [chemical binding]; other site 358681012897 membrane-bound complex binding site; other site 358681012898 hinge residues; other site 358681012899 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 358681012900 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 358681012901 substrate binding pocket [chemical binding]; other site 358681012902 membrane-bound complex binding site; other site 358681012903 hinge residues; other site 358681012904 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 358681012905 dimer interface [polypeptide binding]; other site 358681012906 conserved gate region; other site 358681012907 putative PBP binding loops; other site 358681012908 ABC-ATPase subunit interface; other site 358681012909 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 358681012910 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 358681012911 Walker A/P-loop; other site 358681012912 ATP binding site [chemical binding]; other site 358681012913 Q-loop/lid; other site 358681012914 ABC transporter signature motif; other site 358681012915 Walker B; other site 358681012916 D-loop; other site 358681012917 H-loop/switch region; other site 358681012918 SnoaL-like domain; Region: SnoaL_3; pfam13474 358681012919 SnoaL-like domain; Region: SnoaL_2; pfam12680 358681012920 Nucleotidyltransferase (NT) domain of Staphylococcus aureus kanamycin nucleotidyltransferase, and similar proteins; Region: NT_KNTase_like; cd05403 358681012921 active site 358681012922 NTP binding site [chemical binding]; other site 358681012923 metal binding triad [ion binding]; metal-binding site 358681012924 KNTase C-terminal domain; Region: KNTase_C; pfam07827 358681012925 Transcriptional regulator [Transcription]; Region: LysR; COG0583 358681012926 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 358681012927 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 358681012928 dimerization interface [polypeptide binding]; other site 358681012929 DinB superfamily; Region: DinB_2; pfam12867 358681012930 Nitroreductase-like family which includes NADH oxidase and arsenite oxidiase. NADH oxidase catalyses the oxidation of NAD(P)H and accepts a wide broad range of compounds as electron acceptors, such as nitrocompound. Arsenite oxidase in a...; Region: Arsenite_oxidase; cd02135 358681012931 putative FMN binding site [chemical binding]; other site 358681012932 This family is the oxydase domain of NRPS (non-ribosomal peptide synthetase) and other proteins that modify polypeptides by cyclizing a thioester to form a ring. These include epoB, part of the epothilone biosynthesis pathway; tubD, part of the tubulysin...; Region: mcbC-like_oxidoreductase; cd02142 358681012933 putative FMN binding site [chemical binding]; other site 358681012934 NADPH bind site [chemical binding]; other site 358681012935 Transcriptional regulator [Transcription]; Region: LysR; COG0583 358681012936 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 358681012937 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 358681012938 dimerization interface [polypeptide binding]; other site 358681012939 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 358681012940 YoaP-like; Region: YoaP; pfam14268 358681012941 A predicted NlpC/p60-like peptidase; Region: BtrH; pfam14399 358681012942 Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the "double-glycine" leader peptides from the precursors of various bacteriocins (mostly non-lantibiotic); Region: Peptidase_C39_like; cl00296 358681012943 putative active site [active] 358681012944 Predicted transcriptional regulators [Transcription]; Region: COG1695 358681012945 Transcriptional regulator PadR-like family; Region: PadR; cl17335 358681012946 H+ Antiporter protein; Region: 2A0121; TIGR00900 358681012947 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 358681012948 putative substrate translocation pore; other site 358681012949 Glucoamylase and related glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: SGA1; COG3387 358681012950 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 358681012951 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 358681012952 DNA-binding site [nucleotide binding]; DNA binding site 358681012953 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 358681012954 pyridoxal 5'-phosphate binding site [chemical binding]; other site 358681012955 homodimer interface [polypeptide binding]; other site 358681012956 catalytic residue [active] 358681012957 EamA-like transporter family; Region: EamA; pfam00892 358681012958 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 358681012959 EamA-like transporter family; Region: EamA; pfam00892 358681012960 Glycosyl hydrolases family 15; Region: Glyco_hydro_15; pfam00723 358681012961 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483 358681012962 IMPase, inositol monophosphatase and related domains. A family of Mg++ dependent phosphatases, inhibited by lithium, many of which may act on inositol monophosphate substrate. They dephosphorylate inositol phosphate to generate inositol, which may be...; Region: IMPase; cd01639 358681012963 active site 358681012964 dimerization interface [polypeptide binding]; other site 358681012965 Protein of unknown function (DUF466); Region: DUF466; cl01082 358681012966 carbon starvation protein A; Provisional; Region: PRK15015 358681012967 Carbon starvation protein CstA; Region: CstA; pfam02554 358681012968 C-terminal domain on CstA (DUF4161); Region: DUF4161; pfam13722 358681012969 Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms]; Region: LytT; COG3279 358681012970 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 358681012971 active site 358681012972 phosphorylation site [posttranslational modification] 358681012973 intermolecular recognition site; other site 358681012974 dimerization interface [polypeptide binding]; other site 358681012975 LytTr DNA-binding domain; Region: LytTR; smart00850 358681012976 Putative regulator of cell autolysis [Signal transduction mechanisms]; Region: LytS; COG3275 358681012977 5TMR of 5TMR-LYT; Region: 5TM-5TMR_LYT; pfam07694 358681012978 GAF domain; Region: GAF_3; pfam13492 358681012979 Histidine kinase; Region: His_kinase; pfam06580 358681012980 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 358681012981 ATP binding site [chemical binding]; other site 358681012982 Mg2+ binding site [ion binding]; other site 358681012983 G-X-G motif; other site 358681012984 GNAT acetyltransferase; Region: GNAT_acetyltran; pfam12746 358681012985 4-hydroxyphenylpyruvate dioxygenase; Region: 4HPPD; TIGR01263 358681012986 N-terminal domain of 4-hydroxyphenylpyruvate dioxygenase (HPPD) and hydroxymandelate Synthase (HmaS); Region: HPPD_N_like; cd08342 358681012987 dimer interface [polypeptide binding]; other site 358681012988 C-terminal domain of 4-hydroxyphenylpyruvate dioxygenase (HppD) and hydroxymandelate Synthase (HmaS); Region: HPPD_C_like; cd07250 358681012989 active site 358681012990 Fe binding site [ion binding]; other site 358681012991 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 358681012992 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 358681012993 catalytic residues [active] 358681012994 Rrf2 family protein; Region: rrf2_super; TIGR00738 358681012995 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 358681012996 putative DNA binding site [nucleotide binding]; other site 358681012997 putative Zn2+ binding site [ion binding]; other site 358681012998 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 358681012999 S-adenosylmethionine binding site [chemical binding]; other site 358681013000 M14 family of metallocarboxypeptidases and related proteins; Region: Peptidase_M14_like; cl11393 358681013001 active site 358681013002 Zn binding site [ion binding]; other site 358681013003 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 358681013004 dimer interface [polypeptide binding]; other site 358681013005 putative CheW interface [polypeptide binding]; other site 358681013006 NADP+-dependent p-hydroxybenzaldehyde dehydrogenase-like; Region: ALDH_HBenzADH; cd07151 358681013007 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 358681013008 NAD(P) binding site [chemical binding]; other site 358681013009 catalytic residues [active] 358681013010 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 358681013011 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 358681013012 dimer interface [polypeptide binding]; other site 358681013013 putative CheW interface [polypeptide binding]; other site 358681013014 rRNA (cytosine-C(5)-)-methyltransferase RsmF; Reviewed; Region: yebU; PRK11933 358681013015 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 358681013016 S-adenosylmethionine binding site [chemical binding]; other site 358681013017 pre-rRNA processing and ribosome biogenesis; Region: Nol1_Nop2_Fmu_2; pfam13636 358681013018 flagellar operon protein TIGR03826; Region: YvyF 358681013019 LysE type translocator; Region: LysE; pfam01810 358681013020 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 358681013021 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 358681013022 putative DNA binding site [nucleotide binding]; other site 358681013023 putative Zn2+ binding site [ion binding]; other site 358681013024 AsnC family; Region: AsnC_trans_reg; pfam01037 358681013025 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 358681013026 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 358681013027 putative substrate translocation pore; other site 358681013028 Helix-Turn-Helix DNA binding domain of the BmrR transcription regulator; Region: HTH_BmrR; cd01107 358681013029 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 358681013030 DNA binding residues [nucleotide binding] 358681013031 drug binding residues [chemical binding]; other site 358681013032 dimer interface [polypeptide binding]; other site 358681013033 Bacterial transcription activator, effector binding domain; Region: AraC_E_bind; smart00871 358681013034 helicase 45; Provisional; Region: PTZ00424 358681013035 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 358681013036 ATP binding site [chemical binding]; other site 358681013037 Mg++ binding site [ion binding]; other site 358681013038 motif III; other site 358681013039 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 358681013040 nucleotide binding region [chemical binding]; other site 358681013041 ATP-binding site [chemical binding]; other site 358681013042 RNA polymerase sigma-70 factor, TIGR02954 family; Region: Sig70_famx3 358681013043 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 358681013044 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 358681013045 DNA binding residues [nucleotide binding] 358681013046 Domain of unknown function (DUF4179); Region: DUF4179; pfam13786 358681013047 Cellulase M and related proteins [Carbohydrate transport and metabolism]; Region: FrvX; COG1363 358681013048 M42 Peptidase, Endoglucanases; Region: M42_Frv; cd05656 358681013049 oligomer interface [polypeptide binding]; other site 358681013050 active site 358681013051 metal binding site [ion binding]; metal-binding site 358681013052 Major Facilitator Superfamily; Region: MFS_1; pfam07690 358681013053 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 358681013054 putative substrate translocation pore; other site 358681013055 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 358681013056 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 358681013057 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 358681013058 dipeptidase PepV; Reviewed; Region: PRK07318 358681013059 M20 Peptidase Xaa-His dipeptidase (PepV) degrades hydrophobic dipeptides; Region: M20_PepV; cd03888 358681013060 active site 358681013061 metal binding site [ion binding]; metal-binding site 358681013062 Guanosine polyphosphate pyrophosphohydrolases/synthetases [Signal transduction mechanisms / Transcription]; Region: SpoT; COG0317 358681013063 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 358681013064 synthetase active site [active] 358681013065 NTP binding site [chemical binding]; other site 358681013066 metal binding site [ion binding]; metal-binding site 358681013067 Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840 358681013068 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 358681013069 dimerization interface [polypeptide binding]; other site 358681013070 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 358681013071 dimer interface [polypeptide binding]; other site 358681013072 putative CheW interface [polypeptide binding]; other site 358681013073 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 358681013074 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 358681013075 Coenzyme A binding pocket [chemical binding]; other site 358681013076 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 358681013077 The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504 358681013078 peptide binding site [polypeptide binding]; other site 358681013079 5TMR of 5TMR-LYT; Region: 5TM-5TMR_LYT; pfam07694 358681013080 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 358681013081 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 358681013082 dimer interface [polypeptide binding]; other site 358681013083 phosphorylation site [posttranslational modification] 358681013084 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 358681013085 ATP binding site [chemical binding]; other site 358681013086 Mg2+ binding site [ion binding]; other site 358681013087 G-X-G motif; other site 358681013088 Collagenase and related proteases [Posttranslational modification, protein turnover, chaperones]; Region: COG0826 358681013089 Peptidase family U32; Region: Peptidase_U32; pfam01136 358681013090 Collagenase; Region: DUF3656; pfam12392 358681013091 Peptidase family U32; Region: Peptidase_U32; cl03113 358681013092 Protein of unknown function (DUF1128); Region: DUF1128; pfam06569 358681013093 Domain of unknown function (DUF4179); Region: DUF4179; pfam13786 358681013094 RNA polymerase sigma-70 factor, TIGR02954 family; Region: Sig70_famx3 358681013095 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 358681013096 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 358681013097 DNA binding residues [nucleotide binding] 358681013098 beta-ketoacyl-acyl-carrier-protein synthase II; Region: fabF; TIGR03150 358681013099 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 358681013100 dimer interface [polypeptide binding]; other site 358681013101 active site 358681013102 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 358681013103 sequence-specific DNA binding site [nucleotide binding]; other site 358681013104 salt bridge; other site 358681013105 putative alpha-isopropylmalate/homocitrate synthase family transferase; Provisional; Region: PRK12344 358681013106 Desulfobacterium autotrophicum LeuA3 and related proteins, N-terminal catalytic TIM barrel domain; Region: DRE_TIM_LeuA3; cd07941 358681013107 active site 358681013108 catalytic residues [active] 358681013109 metal binding site [ion binding]; metal-binding site 358681013110 LeuA allosteric (dimerisation) domain; Region: LeuA_dimer; smart00917 358681013111 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 358681013112 YheC/D like ATP-grasp; Region: ATPgrasp_YheCD; pfam14398 358681013113 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 358681013114 M20 Peptidase Aminoacylase 1 family; Region: M20_Acy1; cd03886 358681013115 metal binding site [ion binding]; metal-binding site 358681013116 dimer interface [polypeptide binding]; other site 358681013117 histidinol-phosphatase; Validated; Region: PRK06740 358681013118 Polymerase and Histidinol Phosphatase domain of Histidinol phosphate phosphatase of Hisj like; Region: PHP_HisPPase_Hisj_like; cd12110 358681013119 dimer interface [polypeptide binding]; other site 358681013120 active site 358681013121 Dihydrofolate reductase [Coenzyme metabolism]; Region: FolA; COG0262 358681013122 Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5; Region: DHFR; cd00209 358681013123 folate binding site [chemical binding]; other site 358681013124 NADP+ binding site [chemical binding]; other site 358681013125 thymidylate synthase; Reviewed; Region: thyA; PRK01827 358681013126 Thymidylate synthase and pyrimidine hydroxymethylase: Thymidylate synthase (TS) and deoxycytidylate hydroxymethylase (dCMP-HMase) are homologs that catalyze analogous alkylation of C5 of pyrimidine nucleotides. Both enzymes are involved in the...; Region: TS_Pyrimidine_HMase; cd00351 358681013127 dimerization interface [polypeptide binding]; other site 358681013128 active site 358681013129 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675 358681013130 Helix-turn-helix domain; Region: HTH_OrfB_IS605; pfam12323 358681013131 Probable transposase; Region: OrfB_IS605; pfam01385 358681013132 transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766 358681013133 Transposase IS200 like; Region: Y1_Tnp; pfam01797 358681013134 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 358681013135 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 358681013136 DNA-binding site [nucleotide binding]; DNA binding site 358681013137 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 358681013138 pyridoxal 5'-phosphate binding site [chemical binding]; other site 358681013139 homodimer interface [polypeptide binding]; other site 358681013140 catalytic residue [active] 358681013141 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 358681013142 DNA-binding site [nucleotide binding]; DNA binding site 358681013143 RNA-binding motif; other site 358681013144 Predicted symporter [General function prediction only]; Region: DhlC; COG4147 358681013145 Na(+)/proline cotransporter PutP and related proteins; solute binding domain; Region: SLC5sbd_PutP; cd11475 358681013146 Na binding site [ion binding]; other site 358681013147 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 358681013148 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 358681013149 DNA-binding site [nucleotide binding]; DNA binding site 358681013150 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 358681013151 pyridoxal 5'-phosphate binding site [chemical binding]; other site 358681013152 homodimer interface [polypeptide binding]; other site 358681013153 catalytic residue [active] 358681013154 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 358681013155 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 358681013156 potential frameshift: common BLAST hit: gi|167628812|ref|YP_001679311.1| dynamin family protein 358681013157 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170 358681013158 Dynamin family; Region: Dynamin_N; pfam00350 358681013159 G1 box; other site 358681013160 GTP/Mg2+ binding site [chemical binding]; other site 358681013161 G2 box; other site 358681013162 Switch I region; other site 358681013163 Dynamin-like protein including dynamins, mitofusins, and guanylate-binding proteins; Region: DLP_2; cd09912 358681013164 G3 box; other site 358681013165 Switch II region; other site 358681013166 GTP/Mg2+ binding site [chemical binding]; other site 358681013167 G4 box; other site 358681013168 G5 box; other site 358681013169 Dynamin-like protein including dynamins, mitofusins, and guanylate-binding proteins; Region: DLP_2; cd09912 358681013170 Dynamin family; Region: Dynamin_N; pfam00350 358681013171 G1 box; other site 358681013172 GTP/Mg2+ binding site [chemical binding]; other site 358681013173 G2 box; other site 358681013174 Switch I region; other site 358681013175 G3 box; other site 358681013176 Switch II region; other site 358681013177 G4 box; other site 358681013178 Bacillus/Clostridium GerA spore germination protein; Region: GerA; pfam03323 358681013179 Spore germination protein; Region: Spore_permease; cl17796 358681013180 germination protein, Ger(x)C family; Region: spore_ger_x_C; TIGR02887 358681013181 Spore germination B3/ GerAC like, C-terminal; Region: Spore_GerAC; pfam05504 358681013182 intracellular protease, PfpI family; Region: PfpI; TIGR01382 358681013183 A type 1 glutamine amidotransferase (GATase1)-like domain found in PfpI from Pyrococcus furiosus; Region: GATase1_PfpI_like; cd03134 358681013184 proposed catalytic triad [active] 358681013185 conserved cys residue [active] 358681013186 fosfomycin resistance protein FosB; Provisional; Region: PRK04101 358681013187 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 358681013188 active site 358681013189 metal binding site [ion binding]; metal-binding site 358681013190 superfamily containing globins and truncated hemoglobins; Region: globin_like; cl00280 358681013191 heme-binding site [chemical binding]; other site 358681013192 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 358681013193 dimer interface [polypeptide binding]; other site 358681013194 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 358681013195 putative CheW interface [polypeptide binding]; other site 358681013196 MCP-signal associated domain; Region: MCPsignal_assoc; pfam13682 358681013197 xanthine permease; Region: pbuX; TIGR03173 358681013198 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 358681013199 active site 358681013200 GTPase RsgA; Reviewed; Region: PRK01889 358681013201 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 358681013202 RNA binding site [nucleotide binding]; other site 358681013203 Ribosomal interacting GTPase YjeQ/EngC, a circularly permuted subfamily of the Ras GTPases; Region: YjeQ_EngC; cd01854 358681013204 GTPase/Zn-binding domain interface [polypeptide binding]; other site 358681013205 GTP/Mg2+ binding site [chemical binding]; other site 358681013206 G4 box; other site 358681013207 G5 box; other site 358681013208 G1 box; other site 358681013209 Switch I region; other site 358681013210 G2 box; other site 358681013211 G3 box; other site 358681013212 Switch II region; other site 358681013213 WYL domain; Region: WYL; pfam13280 358681013214 Domain of unknown function (DUF4265); Region: DUF4265; pfam14085 358681013215 Major Facilitator Superfamily; Region: MFS_1; pfam07690 358681013216 Reeler-like domain of YcnI and similar proteins; Region: YcnI_like; cd08545 358681013217 CopC domain; Region: CopC; pfam04234 358681013218 Copper resistance protein D; Region: CopD; cl00563 358681013219 3-oxoadipate enol-lactonase; Region: protocat_pcaD; TIGR02427 358681013220 homoserine O-acetyltransferase; Provisional; Region: metX; cl17114 358681013221 germination protein, Ger(x)C family; Region: spore_ger_x_C; TIGR02887 358681013222 Spore germination B3/ GerAC like, C-terminal; Region: Spore_GerAC; pfam05504 358681013223 Spore germination protein; Region: Spore_permease; cl17796 358681013224 Bacillus/Clostridium GerA spore germination protein; Region: GerA; pfam03323 358681013225 Spermidine/putrescine-binding periplasmic protein [Amino acid transport and metabolism]; Region: PotD; COG0687 358681013226 Bacterial extracellular solute-binding protein; Region: SBP_bac_6; pfam13343 358681013227 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 358681013228 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 358681013229 dimer interface [polypeptide binding]; other site 358681013230 conserved gate region; other site 358681013231 putative PBP binding loops; other site 358681013232 ABC-ATPase subunit interface; other site 358681013233 ABC-type Fe3+ transport system, permease component [Inorganic ion transport and metabolism]; Region: ThiP; COG1178 358681013234 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 358681013235 dimer interface [polypeptide binding]; other site 358681013236 conserved gate region; other site 358681013237 putative PBP binding loops; other site 358681013238 ABC-ATPase subunit interface; other site 358681013239 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 358681013240 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 358681013241 Walker A/P-loop; other site 358681013242 ATP binding site [chemical binding]; other site 358681013243 Q-loop/lid; other site 358681013244 ABC transporter signature motif; other site 358681013245 Walker B; other site 358681013246 D-loop; other site 358681013247 H-loop/switch region; other site 358681013248 TOBE domain; Region: TOBE_2; pfam08402 358681013249 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 358681013250 EamA-like transporter family; Region: EamA; pfam00892 358681013251 EamA-like transporter family; Region: EamA; pfam00892 358681013252 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 358681013253 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 358681013254 DNA-binding site [nucleotide binding]; DNA binding site 358681013255 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 358681013256 pyridoxal 5'-phosphate binding site [chemical binding]; other site 358681013257 homodimer interface [polypeptide binding]; other site 358681013258 catalytic residue [active] 358681013259 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 358681013260 Predicted membrane protein [Function unknown]; Region: COG1238 358681013261 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 358681013262 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 358681013263 Walker A motif; other site 358681013264 ATP binding site [chemical binding]; other site 358681013265 Walker B motif; other site 358681013266 arginine finger; other site 358681013267 UvrB/uvrC motif; Region: UVR; pfam02151 358681013268 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 358681013269 Walker A motif; other site 358681013270 ATP binding site [chemical binding]; other site 358681013271 Walker B motif; other site 358681013272 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 358681013273 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 358681013274 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 358681013275 putative substrate translocation pore; other site 358681013276 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 358681013277 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 358681013278 Cupin domain; Region: Cupin_2; cl17218 358681013279 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 358681013280 Ribokinase catalyses the phosphorylation of ribose to ribose-5-phosphate using ATP. This reaction is the first step in the ribose metabolism. It traps ribose within the cell after uptake and also prepares the sugar for use in the synthesis of nucleotides...; Region: ribokinase; cd01174 358681013281 substrate binding site [chemical binding]; other site 358681013282 dimer interface [polypeptide binding]; other site 358681013283 ATP binding site [chemical binding]; other site 358681013284 Endonuclease_V, a DNA repair enzyme that initiates repair of nitrosative deaminated purine bases; Region: Endonuclease_V; cd06559 358681013285 Active_site [active] 358681013286 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 358681013287 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 358681013288 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 358681013289 Phage late control gene D protein (GPD); Region: Phage_GPD; pfam05954 358681013290 seryl-tRNA synthetase; Provisional; Region: PRK05431 358681013291 SMI1 / KNR4 family (SUKH-1); Region: SMI1_KNR4; pfam09346 358681013292 Uncharacterized protein family (UPF0167); Region: UPF0167; cl01252 358681013293 RHS repeat-associated core domain; Region: Rhs_assc_core; TIGR03696 358681013294 RHS Repeat; Region: RHS_repeat; pfam05593 358681013295 Rhs family protein [Cell envelope biogenesis, outer membrane]; Region: RhsA; COG3209 358681013296 RHS Repeat; Region: RHS_repeat; pfam05593 358681013297 RHS Repeat; Region: RHS_repeat; pfam05593 358681013298 RHS Repeat; Region: RHS_repeat; cl11982 358681013299 RHS Repeat; Region: RHS_repeat; pfam05593 358681013300 RHS Repeat; Region: RHS_repeat; pfam05593 358681013301 RHS Repeat; Region: RHS_repeat; pfam05593 358681013302 RHS Repeat; Region: RHS_repeat; pfam05593 358681013303 RHS Repeat; Region: RHS_repeat; pfam05593 358681013304 RHS Repeat; Region: RHS_repeat; pfam05593 358681013305 RHS Repeat; Region: RHS_repeat; pfam05593 358681013306 RHS repeat-associated core domain; Region: Rhs_assc_core; TIGR03696 358681013307 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2849 358681013308 Phage late control gene D protein (GPD); Region: Phage_GPD; pfam05954 358681013309 Phage late control gene D protein (GPD); Region: Phage_GPD; cl15796 358681013310 YwqJ-like deaminase; Region: YwqJ-deaminase; pfam14431 358681013311 Domain of unknown function (DUF4280); Region: DUF4280; pfam14107 358681013312 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 358681013313 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 358681013314 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 358681013315 Phage late control gene D protein (GPD); Region: Phage_GPD; pfam05954 358681013316 Uncharacterized protein conserved in bacteria (DUF2345); Region: DUF2345; cl01733 358681013317 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 358681013318 nucleotide binding site [chemical binding]; other site 358681013319 Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cl00120 358681013320 Serine/threonine protein phosphatase [Signal transduction mechanisms]; Region: PTC1; COG0631 358681013321 active site 358681013322 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 358681013323 phosphopeptide binding site; other site 358681013324 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 358681013325 phosphopeptide binding site; other site 358681013326 DnaJ-class molecular chaperone with C-terminal Zn finger domain [Posttranslational modification, protein turnover, chaperones]; Region: DnaJ; COG0484 358681013327 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 358681013328 HSP70 interaction site [polypeptide binding]; other site 358681013329 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198 358681013330 metal ion-dependent adhesion site (MIDAS); other site 358681013331 Dystroglycan-type cadherin-like domains; Region: CADG; smart00736 358681013332 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 358681013333 Catalytic domain of Protein Kinases; Region: PKc; cd00180 358681013334 active site 358681013335 ATP binding site [chemical binding]; other site 358681013336 substrate binding site [chemical binding]; other site 358681013337 activation loop (A-loop); other site 358681013338 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 358681013339 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 358681013340 active site 358681013341 metal binding site [ion binding]; metal-binding site 358681013342 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 358681013343 Major Facilitator Superfamily; Region: MFS_1; pfam07690 358681013344 putative substrate translocation pore; other site 358681013345 ABC-type uncharacterized transport system, periplasmic component [General function prediction only]; Region: COG4533 358681013346 Sugar transport-related sRNA regulator N-term; Region: SgrR_N; pfam12793 358681013347 The C-terminal solute-binding domain of DNA-binding transcriptional regulator SgrR is related to the ABC-type oligopeptide-binding proteins and contains the type 2 periplasmic-binding fold; Region: PBP2_SgrR_like; cd08507 358681013348 N-acetylglucosamine-6-phosphate deacetylase [Carbohydrate transport and metabolism]; Region: NagA; COG1820 358681013349 N-acetylglucosamine-6-phosphate deacetylase, NagA, catalyzes the hydrolysis of the N-acetyl group of N-acetyl-glucosamine-6-phosphate (GlcNAc-6-P) to glucosamine 6-phosphate and acetate. This is the first committed step in the biosynthetic pathway to...; Region: NagA; cd00854 358681013350 active site 358681013351 dimer interface [polypeptide binding]; other site 358681013352 Nitronate monooxygenase; Region: NMO; pfam03060 358681013353 2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730 358681013354 FMN binding site [chemical binding]; other site 358681013355 substrate binding site [chemical binding]; other site 358681013356 putative catalytic residue [active] 358681013357 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_2; cd07253 358681013358 dimer interface [polypeptide binding]; other site 358681013359 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 358681013360 metal binding site [ion binding]; metal-binding site 358681013361 Coenzyme A pyrophosphatase (CoAse), a member of the Nudix hydrolase superfamily, functions to catalyze the elimination of oxidized inactive CoA, which can inhibit CoA-utilizing enzymes. The need of CoAses mainly arises under conditions of oxidative...; Region: CoAse; cd03426 358681013362 putative active site [active] 358681013363 putative CoA binding site [chemical binding]; other site 358681013364 nudix motif; other site 358681013365 metal binding site [ion binding]; metal-binding site 358681013366 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 358681013367 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 358681013368 ABC-ATPase subunit interface; other site 358681013369 dimer interface [polypeptide binding]; other site 358681013370 putative PBP binding regions; other site 358681013371 ABC-type enterobactin transport system, permease component [Inorganic ion transport and metabolism]; Region: FepG; COG4779 358681013372 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 358681013373 ABC-ATPase subunit interface; other site 358681013374 dimer interface [polypeptide binding]; other site 358681013375 putative PBP binding regions; other site 358681013376 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 358681013377 ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614 358681013378 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 358681013379 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 358681013380 intersubunit interface [polypeptide binding]; other site 358681013381 ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614 358681013382 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 358681013383 intersubunit interface [polypeptide binding]; other site 358681013384 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 358681013385 helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420 358681013386 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 358681013387 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 358681013388 NAD(P) binding site [chemical binding]; other site 358681013389 Saccharopine dehydrogenase; Region: Saccharop_dh; pfam03435 358681013390 2-aminoethylphosphonate--pyruvate transaminase; Provisional; Region: PRK13479 358681013391 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 358681013392 catalytic residue [active] 358681013393 phosphonoacetaldehyde hydrolase; Provisional; Region: PRK13478 358681013394 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 358681013395 motif II; other site 358681013396 putative 2-aminoethylphosphonate ABC transporter, permease protein; Region: PhnU2; TIGR03262 358681013397 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 358681013398 dimer interface [polypeptide binding]; other site 358681013399 conserved gate region; other site 358681013400 putative PBP binding loops; other site 358681013401 ABC-ATPase subunit interface; other site 358681013402 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 358681013403 dimer interface [polypeptide binding]; other site 358681013404 conserved gate region; other site 358681013405 putative PBP binding loops; other site 358681013406 ABC-ATPase subunit interface; other site 358681013407 putative 2-aminoethylphosphonate ABC transporter, ATP-binding protein; Region: PhnT2; TIGR03265 358681013408 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 358681013409 Walker A/P-loop; other site 358681013410 ATP binding site [chemical binding]; other site 358681013411 Q-loop/lid; other site 358681013412 ABC transporter signature motif; other site 358681013413 Walker B; other site 358681013414 D-loop; other site 358681013415 H-loop/switch region; other site 358681013416 TOBE domain; Region: TOBE_2; pfam08402 358681013417 ABC-type thiamine transport system, periplasmic component [Coenzyme metabolism]; Region: TbpA; COG4143 358681013418 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 358681013419 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 358681013420 Aspartate racemase [Cell envelope biogenesis, outer membrane]; Region: RacX; COG1794 358681013421 aspartate racemase; Region: asp_race; TIGR00035 358681013422 chloramphenicol/florfenicol resistance protein; Provisional; Region: PRK14453 358681013423 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 358681013424 FeS/SAM binding site; other site 358681013425 Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285 358681013426 nucleoside/Zn binding site; other site 358681013427 dimer interface [polypeptide binding]; other site 358681013428 catalytic motif [active] 358681013429 carbamate kinase; Reviewed; Region: PRK12686 358681013430 AAK_CK: Carbamate kinase (CK) catalyzes both the ATP-phosphorylation of carbamate and carbamoyl phosphate (CP) utilization with the production of ATP from ADP and CP. Both CK (this CD) and nonhomologous CP synthetase synthesize carbamoyl phosphate, an...; Region: AAK_CK; cd04235 358681013431 putative substrate binding site [chemical binding]; other site 358681013432 nucleotide binding site [chemical binding]; other site 358681013433 nucleotide binding site [chemical binding]; other site 358681013434 homodimer interface [polypeptide binding]; other site 358681013435 uncharacterized nucleobase-cation-symport-1 (NCS1) transporter subfamily, YbbW-like; solute-binding domain; Region: SLC-NCS1sbd_YbbW-like; cd11485 358681013436 Permease for cytosine/purines, uracil, thiamine, allantoin; Region: Transp_cyt_pur; pfam02133 358681013437 Na binding site [ion binding]; other site 358681013438 putative substrate binding site [chemical binding]; other site 358681013439 Protein of unknown function (DUF1116); Region: DUF1116; pfam06545 358681013440 Succinyl-CoA synthetase, alpha subunit [Energy production and conversion]; Region: SucD; COG0074 358681013441 CoA binding domain; Region: CoA_binding; pfam02629 358681013442 CoA-ligase; Region: Ligase_CoA; pfam00549 358681013443 Protein of unknown function (DUF2877); Region: DUF2877; pfam11392 358681013444 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 358681013445 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 358681013446 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 358681013447 Purine catabolism regulatory protein-like family; Region: PucR; pfam07905 358681013448 PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556 358681013449 Protein of unknown function (DUF1696); Region: DUF1696; pfam08000 358681013450 YvbH-like oligomerisation region; Region: YvbH_ext; pfam11724 358681013451 Nitroreductase-like family which includes NADH oxidase and arsenite oxidiase. NADH oxidase catalyses the oxidation of NAD(P)H and accepts a wide broad range of compounds as electron acceptors, such as nitrocompound. Arsenite oxidase in a...; Region: Arsenite_oxidase; cd02135 358681013452 putative FMN binding site [chemical binding]; other site 358681013453 This group of proteins belong to a large family of YjgF/YER057c/UK114-like proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence...; Region: YjgF_YER057c_UK114_like_6; cd06154 358681013454 homotrimer interaction site [polypeptide binding]; other site 358681013455 putative active site [active] 358681013456 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 358681013457 binding surface 358681013458 FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790 358681013459 TPR motif; other site 358681013460 Sel1 repeat; Region: Sel1; pfam08238 358681013461 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 358681013462 TPR motif; other site 358681013463 binding surface 358681013464 Uncharacterized proteins, LmbE homologs [Function unknown]; Region: COG2120 358681013465 Predicted N-acetylglucosamine kinase [Carbohydrate transport and metabolism]; Region: COG2971 358681013466 argininosuccinate lyase; Provisional; Region: PRK06705 358681013467 Argininosuccinate lyase (argininosuccinase, ASAL); Region: Argininosuccinate_lyase; cd01359 358681013468 active sites [active] 358681013469 tetramer interface [polypeptide binding]; other site 358681013470 GlcNAc-PI de-N-acetylase; Region: PIG-L; cl00929 358681013471 NPCBM-associated, NEW3 domain of alpha-galactosidase; Region: NPCBM_assoc; pfam10633 358681013472 NPCBM-associated, NEW3 domain of alpha-galactosidase; Region: NPCBM_assoc; pfam10633 358681013473 GlcNAc-PI de-N-acetylase; Region: PIG-L; cl00929 358681013474 NPCBM-associated, NEW3 domain of alpha-galactosidase; Region: NPCBM_assoc; pfam10633 358681013475 Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GAT_1; cl00020 358681013476 ABC-type Fe3+ transport system, permease component [Inorganic ion transport and metabolism]; Region: ThiP; COG1178 358681013477 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 358681013478 dimer interface [polypeptide binding]; other site 358681013479 conserved gate region; other site 358681013480 putative PBP binding loops; other site 358681013481 ABC-ATPase subunit interface; other site 358681013482 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 358681013483 dimer interface [polypeptide binding]; other site 358681013484 conserved gate region; other site 358681013485 putative PBP binding loops; other site 358681013486 ABC-ATPase subunit interface; other site 358681013487 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 358681013488 ATP-binding cassette domain of the polyamine transporter; Region: ABC_PotA_N; cd03300 358681013489 Walker A/P-loop; other site 358681013490 ATP binding site [chemical binding]; other site 358681013491 Q-loop/lid; other site 358681013492 ABC transporter signature motif; other site 358681013493 Walker B; other site 358681013494 D-loop; other site 358681013495 H-loop/switch region; other site 358681013496 2-aminoethylphosphonate ABC transporter substrate-binding protein; Provisional; Region: PRK15046 358681013497 ABC-type Fe3+ transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: AfuA; COG1840 358681013498 MarR family; Region: MarR_2; pfam12802 358681013499 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 358681013500 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 358681013501 nucleotide binding site [chemical binding]; other site 358681013502 Transcriptional regulator [Transcription]; Region: LysR; COG0583 358681013503 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 358681013504 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 358681013505 dimerization interface [polypeptide binding]; other site 358681013506 transaminase; Validated; Region: PRK07324 358681013507 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 358681013508 pyridoxal 5'-phosphate binding site [chemical binding]; other site 358681013509 homodimer interface [polypeptide binding]; other site 358681013510 catalytic residue [active] 358681013511 ornithine cyclodeaminase; Validated; Region: PRK06823; cl17400 358681013512 alanine dehydrogenase; Validated; Region: PRK06046 358681013513 helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346 358681013514 Transcriptional regulator [Transcription]; Region: IclR; COG1414 358681013515 Bacterial transcriptional regulator; Region: IclR; pfam01614 358681013516 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 358681013517 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 358681013518 dimer interface [polypeptide binding]; other site 358681013519 conserved gate region; other site 358681013520 putative PBP binding loops; other site 358681013521 ABC-ATPase subunit interface; other site 358681013522 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 358681013523 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 358681013524 substrate binding pocket [chemical binding]; other site 358681013525 membrane-bound complex binding site; other site 358681013526 hinge residues; other site 358681013527 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 358681013528 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 358681013529 Walker A/P-loop; other site 358681013530 ATP binding site [chemical binding]; other site 358681013531 Q-loop/lid; other site 358681013532 ABC transporter signature motif; other site 358681013533 Walker B; other site 358681013534 D-loop; other site 358681013535 H-loop/switch region; other site 358681013536 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 358681013537 Beta-lactamase; Region: Beta-lactamase; pfam00144 358681013538 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 358681013539 Domain of unknown function (DUF1768); Region: DUF1768; pfam08719 358681013540 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3878 358681013541 Anion-transporting ATPase; Region: ArsA_ATPase; pfam02374 358681013542 ArsA ATPase functionas as an efflux pump located on the inner membrane of the cell. This ATP-driven oxyanion pump catalyzes the extrusion of arsenite, antimonite and arsenate. Maintenance of a low intracellular concentration of oxyanion produces...; Region: ArsA; cd02035 358681013543 P loop; other site 358681013544 Nucleotide binding site [chemical binding]; other site 358681013545 DTAP/Switch II; other site 358681013546 Switch I; other site 358681013547 MarR family; Region: MarR; pfam01047 358681013548 Small acid-soluble spore protein H family; Region: SspH; pfam08141 358681013549 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 358681013550 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 358681013551 Polysaccharide pyruvyl transferase family protein [Cell wall/membrane/envelope biogenesis]; Region: WcaK; COG2327 358681013552 Polysaccharide pyruvyl transferase; Region: PS_pyruv_trans; cl09156 358681013553 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 358681013554 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 358681013555 active site 358681013556 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 358681013557 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 358681013558 Glycosyl transferase family 2; Region: Glycos_transf_2; pfam00535 358681013559 active site 358681013560 Predicted membrane protein [Function unknown]; Region: COG4129 358681013561 Bacterial protein of unknown function (DUF939); Region: DUF939; pfam06081 358681013562 DUF939 C-terminal domain; Region: DUF939_C; pfam11728 358681013563 putative heme peroxidase; Provisional; Region: PRK12276 358681013564 6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase [Carbohydrate transport and metabolism]; Region: NagB; COG0363 358681013565 GlcN6P_deaminase: Glucosamine-6-phosphate (GlcN6P) deaminase subfamily; GlcN6P deaminase catalyzes the reversible conversion of GlcN6P to D-fructose-6-phosphate (Fru6P) and ammonium. The reaction is an aldo-keto isomerization coupled with an amination or...; Region: GlcN6P_deaminase; cd01399 358681013566 active site 358681013567 trimer interface [polypeptide binding]; other site 358681013568 allosteric site; other site 358681013569 active site lid [active] 358681013570 hexamer (dimer of trimers) interface [polypeptide binding]; other site 358681013571 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 358681013572 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 358681013573 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 358681013574 putative active site [active] 358681013575 C-terminal domain of adaptor protein (AP) complexes medium mu subunits and its homologs (MHD); Region: AP_MHD_Cterm; cl10970 358681013576 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 358681013577 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 358681013578 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 358681013579 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 358681013580 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 358681013581 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 358681013582 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 358681013583 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 358681013584 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 358681013585 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 358681013586 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 358681013587 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 358681013588 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 358681013589 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 358681013590 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 358681013591 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 358681013592 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 358681013593 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 358681013594 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 358681013595 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 358681013596 hypothetical protein; Provisional; Region: PRK13673 358681013597 hydroxyproline-2-epimerase; Provisional; Region: PRK13971 358681013598 Proline racemase; Region: Pro_racemase; pfam05544 358681013599 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 358681013600 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 358681013601 NAD(P) binding site [chemical binding]; other site 358681013602 catalytic residues [active] 358681013603 Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329 358681013604 Dihydrodipicolinate synthase family; Region: DHDPS-like; cd00408 358681013605 inhibitor site; inhibition site 358681013606 active site 358681013607 dimer interface [polypeptide binding]; other site 358681013608 catalytic residue [active] 358681013609 hydroxyproline-2-epimerase; Provisional; Region: PRK13971 358681013610 Proline racemase; Region: Pro_racemase; pfam05544 358681013611 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 358681013612 hydroxyglutarate oxidase; Provisional; Region: PRK11728 358681013613 PAS domain S-box; Region: sensory_box; TIGR00229 358681013614 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 358681013615 putative active site [active] 358681013616 heme pocket [chemical binding]; other site 358681013617 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204 358681013618 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 358681013619 Walker A motif; other site 358681013620 ATP binding site [chemical binding]; other site 358681013621 Walker B motif; other site 358681013622 arginine finger; other site 358681013623 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 358681013624 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 358681013625 ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683 358681013626 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 358681013627 The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504 358681013628 peptide binding site [polypeptide binding]; other site 358681013629 Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006 358681013630 Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321 358681013631 Similar to Prolidase and Aminopeptidase P. The members of this subfamily presumably catalyse hydrolysis of Xaa-Pro dipeptides and/or release of any N-terminal amino acid, including proline, that is linked with proline; Region: APP-like; cd01092 358681013632 active site 358681013633 2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_4; pfam13510 358681013634 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 358681013635 Uncharacterized conserved protein (DUF2161); Region: DUF2161; cl02298 358681013636 Uncharacterized conserved protein [Function unknown]; Region: COG1284 358681013637 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 358681013638 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 358681013639 Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; pfam10035 358681013640 Fe2+/Zn2+ uptake regulation proteins [Inorganic ion transport and metabolism]; Region: Fur; COG0735 358681013641 putative DNA binding helix; other site 358681013642 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 358681013643 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 358681013644 active site 358681013645 catalytic tetrad [active] 358681013646 Predicted transcriptional regulators [Transcription]; Region: COG1733 358681013647 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 358681013648 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 358681013649 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 358681013650 active site 358681013651 catalytic tetrad [active] 358681013652 Beta-lactamase enzyme family; Region: Beta-lactamase2; pfam13354 358681013653 Spore germination protein; Region: Spore_permease; cl17796 358681013654 Uncharacterized protein involved in copper resistance [Inorganic ion transport and metabolism]; Region: CutC; COG3142 358681013655 L-asparaginase II; Region: Asparaginase_II; pfam06089 358681013656 ExsB is a transcription regulator related protein. It is a subfamily of a Adenosine nucleotide binding superfamily of proteins. This protein family is represented by a single member in nearly every completed large (> 1000 genes) prokaryotic genome. In...; Region: ExsB; cd01995 358681013657 Ligand Binding Site [chemical binding]; other site 358681013658 6-pyruvoyl tetrahydropterin synthase; Region: PTPS; pfam01242 358681013659 active site 358681013660 7-cyano-7-deazaguanosine (preQ0) biosynthesis protein QueE; Region: Bsubt_queE; TIGR03365 358681013661 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 358681013662 FeS/SAM binding site; other site 358681013663 7-cyano-7-deazaguanine reductase; Provisional; Region: PRK13258 358681013664 TIGR03987 family protein; Region: TIGR03987 358681013665 Truncated hemoglobins (trHbs) are a family of oxygen-binding heme proteins found in cyanobacteria, eubacteria, unicellular eukaryotes, and plants. The truncated hemoglobins have a characteristic two-over-two alpha helical folding pattern that is distinct...; Region: Trunc_globin; cd00454 358681013666 apolar tunnel; other site 358681013667 heme binding site [chemical binding]; other site 358681013668 dimerization interface [polypeptide binding]; other site 358681013669 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 358681013670 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 358681013671 Coenzyme A binding pocket [chemical binding]; other site 358681013672 signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227 358681013673 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 358681013674 Catalytic site [active] 358681013675 YmaF family; Region: YmaF; pfam12788 358681013676 ABC-type transport system involved in cytochrome bd biosynthesis, fused ATPase and permease components [Energy production and conversion / Posttranslational modification, protein turnover, chaperones]; Region: CydC; COG4987 358681013677 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 358681013678 ATP-binding cassette domain of CydCD, subfamily C; Region: ABCC_cytochrome_bd; cd03247 358681013679 Walker A/P-loop; other site 358681013680 ATP binding site [chemical binding]; other site 358681013681 Q-loop/lid; other site 358681013682 ABC transporter signature motif; other site 358681013683 Walker B; other site 358681013684 D-loop; other site 358681013685 H-loop/switch region; other site 358681013686 ABC-type transport system involved in cytochrome bd biosynthesis, ATPase and permease components [Energy production and conversion / Posttranslational modification, protein turnover, chaperones]; Region: CydD; COG4988 358681013687 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 358681013688 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 358681013689 Walker A/P-loop; other site 358681013690 ATP binding site [chemical binding]; other site 358681013691 Q-loop/lid; other site 358681013692 ABC transporter signature motif; other site 358681013693 Walker B; other site 358681013694 D-loop; other site 358681013695 H-loop/switch region; other site 358681013696 cytochrome d ubiquinol oxidase subunit 2; Provisional; Region: PRK15003; cl12219 358681013697 Cytochrome oxidase subunit II; Region: Cyto_ox_2; pfam02322 358681013698 cytochrome d terminal oxidase subunit 1; Provisional; Region: PRK15097 358681013699 Bacterial Cytochrome Ubiquinol Oxidase; Region: Bac_Ubq_Cox; pfam01654 358681013700 Domain of unknown function (DUF4367); Region: DUF4367; pfam14285 358681013701 RNA polymerase sigma-70 factor, TIGR02952 family; Region: Sig70_famx2 358681013702 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 358681013703 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 358681013704 DNA binding residues [nucleotide binding] 358681013705 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 358681013706 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 358681013707 Bacterial SH3 domain; Region: SH3_3; pfam08239 358681013708 Bacterial SH3 domain; Region: SH3_3; cl17532 358681013709 Bacterial SH3 domain; Region: SH3_3; cl17532 358681013710 Bacterial SH3 domain; Region: SH3_3; pfam08239 358681013711 stage II sporulation protein P; Region: spore_II_P; TIGR02867 358681013712 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 358681013713 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 358681013714 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 358681013715 homotrimer interaction site [polypeptide binding]; other site 358681013716 putative active site [active] 358681013717 Brown fat-inducible thioesterase (BFIT). Brain acyl-CoA hydrolase (BACH). These enzymes deacylate long-chain fatty acids by hydrolyzing acyl-CoA thioesters to free fatty acids and CoA-SH. Eukaryotic members of this family are expressed in brain, testis; Region: BFIT_BACH; cd03442 358681013718 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 358681013719 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 358681013720 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 358681013721 Domain of unknown function DUF20; Region: UPF0118; pfam01594 358681013722 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084 358681013723 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 358681013724 DNA-binding transcriptional activator YeiL; Provisional; Region: PRK10402 358681013725 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 358681013726 ligand binding site [chemical binding]; other site 358681013727 flexible hinge region; other site 358681013728 Crp-like helix-turn-helix domain; Region: HTH_Crp_2; pfam13545 358681013729 Protein of unknown function, DUF606; Region: DUF606; pfam04657 358681013730 Leucyl aminopeptidase (aminopeptidase T) [Amino acid transport and metabolism]; Region: AmpS; COG2309 358681013731 Thermophilic metalloprotease (M29); Region: Peptidase_M29; pfam02073 358681013732 Uncharacterized membrane protein [Function unknown]; Region: SapB; COG1285 358681013733 MgtC family; Region: MgtC; pfam02308 358681013734 UDP-N-acetylmuramyl pentapeptide phosphotransferase/UDP-N- acetylglucosamine-1-phosphate transferase [Cell envelope biogenesis, outer membrane]; Region: Rfe; COG0472 358681013735 This subfamily contains Escherichia coli WecA, Bacillus subtilis TagO and related proteins. WecA is an UDP-N-acetylglucosamine (GlcNAc):undecaprenyl-phosphate (Und-P) GlcNAc-1-phosphate transferase that catalyzes the formation of a phosphodiester bond...; Region: GT_WecA_like; cd06853 358681013736 Mg++ binding site [ion binding]; other site 358681013737 putative catalytic motif [active] 358681013738 substrate binding site [chemical binding]; other site 358681013739 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 358681013740 Coenzyme A binding pocket [chemical binding]; other site 358681013741 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 358681013742 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 358681013743 Coenzyme A binding pocket [chemical binding]; other site 358681013744 DEDDh 3'-5' exonuclease domain of Caenorhabditis elegans ERI-1, human 3' exonuclease, and similar proteins; Region: ERI-1_3'hExo_like; cd06133 358681013745 active site 358681013746 catalytic site [active] 358681013747 substrate binding site [chemical binding]; other site 358681013748 Beta-lactamase enzyme family; Region: Beta-lactamase2; pfam13354 358681013749 The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504 358681013750 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 358681013751 peptide binding site [polypeptide binding]; other site 358681013752 Uncharacterized protein conserved in bacteria (DUF2325); Region: DUF2325; cl01811 358681013753 Uncharacterized small protein (DUF2292); Region: DUF2292; pfam10055 358681013754 dipeptide transporter ATP-binding subunit; Provisional; Region: dppF; PRK11308 358681013755 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 358681013756 Walker A/P-loop; other site 358681013757 ATP binding site [chemical binding]; other site 358681013758 Q-loop/lid; other site 358681013759 ABC transporter signature motif; other site 358681013760 Walker B; other site 358681013761 D-loop; other site 358681013762 H-loop/switch region; other site 358681013763 oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727 358681013764 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 358681013765 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 358681013766 Walker A/P-loop; other site 358681013767 ATP binding site [chemical binding]; other site 358681013768 Q-loop/lid; other site 358681013769 ABC transporter signature motif; other site 358681013770 Walker B; other site 358681013771 D-loop; other site 358681013772 H-loop/switch region; other site 358681013773 oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727 358681013774 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 358681013775 N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911 358681013776 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 358681013777 dimer interface [polypeptide binding]; other site 358681013778 conserved gate region; other site 358681013779 putative PBP binding loops; other site 358681013780 ABC-ATPase subunit interface; other site 358681013781 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 358681013782 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 358681013783 dimer interface [polypeptide binding]; other site 358681013784 conserved gate region; other site 358681013785 putative PBP binding loops; other site 358681013786 ABC-ATPase subunit interface; other site 358681013787 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 358681013788 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cd00995 358681013789 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270 358681013790 active site 358681013791 ATP binding site [chemical binding]; other site 358681013792 Phosphotransferase enzyme family; Region: APH; pfam01636 358681013793 Escherichia coli PhnB and similar proteins; the E. coli phnB gene is found next to an operon involved in the cleavage of carbon-phosphorus bonds in unactivated alkylphosphonates; Region: PhnB_like; cd06588 358681013794 dimer interface [polypeptide binding]; other site 358681013795 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 358681013796 Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220 358681013797 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 358681013798 Carboxymuconolactone decarboxylase family; Region: CMD; cl00460 358681013799 Helix-Turn-Helix DNA binding domain of the MerR-like transcription regulators YyaN and YraB; Region: HTH_YyaN; cd01109 358681013800 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 358681013801 DNA binding residues [nucleotide binding] 358681013802 putative dimer interface [polypeptide binding]; other site 358681013803 CapA and related proteins, metallophosphatase domain; Region: MPP_CapA; cd07381 358681013804 Bacterial capsule synthesis protein PGA_cap; Region: PGA_cap; smart00854 358681013805 putative active site [active] 358681013806 putative metal binding site [ion binding]; other site 358681013807 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189 358681013808 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 358681013809 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 358681013810 DNA binding residues [nucleotide binding] 358681013811 dimerization interface [polypeptide binding]; other site 358681013812 Predicted nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG0702 358681013813 triphenylmethane reductase (TMR)-like proteins, NMRa-like, atypical (a) SDRs; Region: TMR_SDR_a; cd05269 358681013814 NADP binding site [chemical binding]; other site 358681013815 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 358681013816 MarR family; Region: MarR; pfam01047 358681013817 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK08217 358681013818 17hydroxysteroid dehydrogenase type 10 (HSD10)-like, classical (c) SDRs; Region: HSD10-like_SDR_c; cd05371 358681013819 NAD binding site [chemical binding]; other site 358681013820 homodimer interface [polypeptide binding]; other site 358681013821 homotetramer interface [polypeptide binding]; other site 358681013822 active site 358681013823 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 358681013824 Coenzyme A binding pocket [chemical binding]; other site 358681013825 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3181 358681013826 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3333 358681013827 Tripartite tricarboxylate transporter TctB family; Region: TctB; pfam07331 358681013828 HD domain; Region: HD_3; cl17350 358681013829 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 358681013830 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 358681013831 non-specific DNA binding site [nucleotide binding]; other site 358681013832 salt bridge; other site 358681013833 sequence-specific DNA binding site [nucleotide binding]; other site 358681013834 Bacterial EndoU nuclease; Region: EndoU_bacteria; pfam14436 358681013835 Zn-dependent alcohol dehydrogenases [General function prediction only]; Region: AdhP; COG1064 358681013836 Cinnamyl alcohol dehydrogenases (CAD); Region: CAD3; cd08297 358681013837 NAD binding site [chemical binding]; other site 358681013838 substrate binding site [chemical binding]; other site 358681013839 catalytic Zn binding site [ion binding]; other site 358681013840 tetramer interface [polypeptide binding]; other site 358681013841 structural Zn binding site [ion binding]; other site 358681013842 Iron-containing alcohol dehydrogenases-like; Region: Fe-ADH4; cd08188 358681013843 Alcohol dehydrogenase, class IV [Energy production and conversion]; Region: EutG; COG1454 358681013844 putative active site [active] 358681013845 metal binding site [ion binding]; metal-binding site 358681013846 GAF domain; Region: GAF_3; pfam13492 358681013847 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 358681013848 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 358681013849 phosphorylation site [posttranslational modification] 358681013850 dimer interface [polypeptide binding]; other site 358681013851 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 358681013852 ATP binding site [chemical binding]; other site 358681013853 Mg2+ binding site [ion binding]; other site 358681013854 G-X-G motif; other site 358681013855 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204 358681013856 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 358681013857 active site 358681013858 phosphorylation site [posttranslational modification] 358681013859 intermolecular recognition site; other site 358681013860 dimerization interface [polypeptide binding]; other site 358681013861 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 358681013862 Walker A motif; other site 358681013863 ATP binding site [chemical binding]; other site 358681013864 Walker B motif; other site 358681013865 arginine finger; other site 358681013866 benzoate transporter; Region: benE; TIGR00843 358681013867 Benzoate membrane transport protein; Region: BenE; pfam03594 358681013868 short chain dehydrogenase; Provisional; Region: PRK08303 358681013869 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 358681013870 NAD(P) binding site [chemical binding]; other site 358681013871 active site 358681013872 Predicted transcriptional regulator [Transcription]; Region: COG2378 358681013873 HTH domain; Region: HTH_11; pfam08279 358681013874 WYL domain; Region: WYL; pfam13280 358681013875 benzoate transport; Region: 2A0115; TIGR00895 358681013876 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 358681013877 putative substrate translocation pore; other site 358681013878 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 358681013879 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 358681013880 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 358681013881 Transcriptional regulator [Transcription]; Region: LysR; COG0583 358681013882 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 358681013883 The C-terminal substrate binding domain of LysR-type transcriptional regulators, YofA and SoxR, contains the type 2 periplasmic binding fold; Region: PBP2_YofA_SoxR_like; cd08442 358681013884 putative dimerization interface [polypeptide binding]; other site 358681013885 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 358681013886 Cache domain; Region: Cache_1; pfam02743 358681013887 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 358681013888 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 358681013889 dimer interface [polypeptide binding]; other site 358681013890 putative CheW interface [polypeptide binding]; other site 358681013891 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 358681013892 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 358681013893 Coenzyme A binding pocket [chemical binding]; other site 358681013894 Lipoate-protein ligase A [Coenzyme metabolism]; Region: LplA; COG0095 358681013895 lipoyltransferase and lipoate-protein ligase; Region: lipoyltrans; TIGR00545 358681013896 Bacterial lipoate protein ligase C-terminus; Region: Lip_prot_lig_C; pfam10437 358681013897 Cache domain; Region: Cache_2; cl07034 358681013898 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 358681013899 dimerization interface [polypeptide binding]; other site 358681013900 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 358681013901 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 358681013902 dimer interface [polypeptide binding]; other site 358681013903 putative CheW interface [polypeptide binding]; other site 358681013904 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 358681013905 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 358681013906 dimer interface [polypeptide binding]; other site 358681013907 phosphorylation site [posttranslational modification] 358681013908 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 358681013909 ATP binding site [chemical binding]; other site 358681013910 Mg2+ binding site [ion binding]; other site 358681013911 G-X-G motif; other site 358681013912 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 358681013913 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 358681013914 active site 358681013915 phosphorylation site [posttranslational modification] 358681013916 intermolecular recognition site; other site 358681013917 dimerization interface [polypeptide binding]; other site 358681013918 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 358681013919 DNA binding site [nucleotide binding] 358681013920 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 358681013921 Peptidase family M23; Region: Peptidase_M23; pfam01551 358681013922 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 358681013923 dimerization interface [polypeptide binding]; other site 358681013924 putative DNA binding site [nucleotide binding]; other site 358681013925 putative Zn2+ binding site [ion binding]; other site 358681013926 EamA-like transporter family; Region: EamA; pfam00892 358681013927 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 358681013928 EamA-like transporter family; Region: EamA; pfam00892 358681013929 Coenzyme F390 synthetase [Coenzyme metabolism]; Region: PaaK; COG1541 358681013930 putative adenylate-forming enzyme; Region: aden_form_hyp; TIGR02304 358681013931 Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491 358681013932 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 358681013933 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 358681013934 NAD(P) binding site [chemical binding]; other site 358681013935 active site 358681013936 hypothetical protein; Provisional; Region: PRK06849 358681013937 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 358681013938 ATP-grasp domain; Region: ATP-grasp_4; pfam13535 358681013939 3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK07204 358681013940 Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830 358681013941 dimer interface [polypeptide binding]; other site 358681013942 active site 358681013943 CoA binding pocket [chemical binding]; other site 358681013944 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 358681013945 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 358681013946 active site 358681013947 phosphorylation site [posttranslational modification] 358681013948 intermolecular recognition site; other site 358681013949 dimerization interface [polypeptide binding]; other site 358681013950 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 358681013951 DNA binding site [nucleotide binding] 358681013952 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 358681013953 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 358681013954 dimerization interface [polypeptide binding]; other site 358681013955 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 358681013956 dimer interface [polypeptide binding]; other site 358681013957 phosphorylation site [posttranslational modification] 358681013958 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 358681013959 ATP binding site [chemical binding]; other site 358681013960 Mg2+ binding site [ion binding]; other site 358681013961 G-X-G motif; other site 358681013962 proline-specific peptidase, Bacillus coagulans-type subfamily; Region: pro_imino_pep_2; TIGR01250 358681013963 penicillin-binding protein 2; Region: pbp2_mrdA; TIGR03423 358681013964 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 358681013965 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 358681013966 NTF2-like N-terminal transpeptidase domain; Region: MecA_N; pfam05223 358681013967 penicillin-binding protein 2; Region: pbp2_mrdA; TIGR03423 358681013968 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 358681013969 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 358681013970 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 358681013971 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 358681013972 phosphopeptide binding site; other site 358681013973 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 358681013974 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 358681013975 DNA binding site [nucleotide binding] 358681013976 Cupin domain; Region: Cupin_2; cl17218 358681013977 Uncharacterized conserved protein (DUF2277); Region: DUF2277; pfam10041 358681013978 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_7; cd08353 358681013979 putative dimer interface [polypeptide binding]; other site 358681013980 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 358681013981 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 358681013982 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 358681013983 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 358681013984 active site 358681013985 catalytic tetrad [active] 358681013986 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 358681013987 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 358681013988 Coenzyme A binding pocket [chemical binding]; other site 358681013989 Predicted permeases [General function prediction only]; Region: COG0679 358681013990 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 358681013991 Fructokinases (FRKs) mainly from bacteria and plants are enzymes with high specificity for fructose, as are all FRKs, but they catalyzes the conversion of fructose to fructose-6-phosphate, which is an entry point into glycolysis via conversion into...; Region: bac_FRK; cd01167 358681013992 putative substrate binding site [chemical binding]; other site 358681013993 putative ATP binding site [chemical binding]; other site 358681013994 delta endotoxin, N-terminal domain; Region: Endotoxin_N; pfam03945 358681013995 delta endotoxin; Region: Endotoxin_C; pfam03944 358681013996 metal binding site [ion binding]; metal-binding site 358681013997 metal-dependent hydrolase; Provisional; Region: PRK13291 358681013998 DinB superfamily; Region: DinB_2; pfam12867 358681013999 D-cysteine desulfhydrase; Validated; Region: PRK03910 358681014000 Tryptophan synthase beta superfamily (fold type II); this family of pyridoxal phosphate (PLP)-dependent enzymes catalyzes beta-replacement and beta-elimination reactions. This CD corresponds to aminocyclopropane-1-carboxylate deaminase (ACCD), tryptophan...; Region: Trp-synth-beta_II; cl00342 358681014001 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 358681014002 catalytic residue [active] 358681014003 Protein of unknown function (DUF2569); Region: DUF2569; pfam10754 358681014004 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 358681014005 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 358681014006 ligand binding site [chemical binding]; other site 358681014007 flexible hinge region; other site 358681014008 DoxX-like family; Region: DoxX_2; pfam13564 358681014009 Protein of unknown function (DUF3267); Region: DUF3267; pfam11667 358681014010 Co/Zn/Cd efflux system component [Inorganic ion transport and metabolism]; Region: CzcD; COG1230 358681014011 Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053 358681014012 N-acetylmuramic acid-6-phosphate etherase; Reviewed; Region: murQ; PRK05441 358681014013 N-acetylmuramic acid 6-phosphate etherase. Members of this family contain the SIS (Sugar ISomerase) domain. The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. The bacterial cell wall sugar N-acetylmuramic acid...; Region: SIS_Etherase; cd05007 358681014014 putative active site [active] 358681014015 Beta-glucosidase-related glycosidases [Carbohydrate transport and metabolism]; Region: BglX; COG1472 358681014016 Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; pfam00933 358681014017 Glycosyl hydrolase family 3 C-terminal domain; Region: Glyco_hydro_3_C; pfam01915 358681014018 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 358681014019 Coenzyme A binding pocket [chemical binding]; other site 358681014020 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 358681014021 Coenzyme A binding pocket [chemical binding]; other site 358681014022 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 358681014023 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 358681014024 dimer interface [polypeptide binding]; other site 358681014025 conserved gate region; other site 358681014026 putative PBP binding loops; other site 358681014027 ABC-ATPase subunit interface; other site 358681014028 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 358681014029 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 358681014030 dimer interface [polypeptide binding]; other site 358681014031 conserved gate region; other site 358681014032 putative PBP binding loops; other site 358681014033 ABC-ATPase subunit interface; other site 358681014034 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 358681014035 Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416 358681014036 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 358681014037 PAP2_like proteins, BcrC_like subfamily. Several members of this family have been annotated as bacitracin transport permeases, as it was suspected that they form the permease component of an ABC transporter system. It was shown, however, that BcrC from...; Region: PAP2_BcrC_like; cd03385 358681014038 active site 358681014039 short chain dehydrogenase; Provisional; Region: PRK06701 358681014040 classical (c) SDR, subgroup 1; Region: SDR_c1; cd05355 358681014041 NAD binding site [chemical binding]; other site 358681014042 metal binding site [ion binding]; metal-binding site 358681014043 active site 358681014044 Domain of unknown function (DUF4183); Region: DUF4183; pfam13799 358681014045 Domain of unknown function (DUF4183); Region: DUF4183; pfam13799 358681014046 Hemerythrin-like domain; Region: Hr-like; cd12108 358681014047 Fe binding site [ion binding]; other site 358681014048 Solute carrier families 5 and 6-like; solute binding domain; Region: SLC5-6-like_sbd; cl00456 358681014049 Rieske Fe-S protein [Energy production and conversion]; Region: QcrA; COG0723 358681014050 Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cd03467 358681014051 iron-sulfur cluster [ion binding]; other site 358681014052 [2Fe-2S] cluster binding site [ion binding]; other site 358681014053 DMSO reductase, iron-sulfur subunit; Region: DMSO_dmsB; TIGR02951 358681014054 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 358681014055 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 358681014056 formate dehydrogenase, alpha subunit, archaeal-type; Region: Fdh-alpha; TIGR01591 358681014057 Nitrate reductases, NapA (Nitrate-R-NapA), NasA, and NarB catalyze the reduction of nitrate to nitrite. Monomeric Nas is located in the cytoplasm and participates in nitrogen assimilation. Dimeric Nap is located in the periplasm and is coupled to quinol...; Region: MopB_Nitrate-R-NapA-like; cd02754 358681014058 [4Fe-4S] binding site [ion binding]; other site 358681014059 molybdopterin cofactor binding site; other site 358681014060 This CD includes formate dehydrogenases (Fdh) H and N; nitrate reductases, Nap and Nas; and other related proteins. Formate dehydrogenase H is a component of the anaerobic formate hydrogen lyase complex and catalyzes the reversible oxidation of formate...; Region: MopB_CT_Fdh-Nap-like; cd00508 358681014061 molybdopterin cofactor binding site; other site 358681014062 CitB domain protein; Region: CitB; TIGR02484 358681014063 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 358681014064 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 358681014065 ligand binding site [chemical binding]; other site 358681014066 flexible hinge region; other site 358681014067 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 358681014068 putative switch regulator; other site 358681014069 non-specific DNA interactions [nucleotide binding]; other site 358681014070 DNA binding site [nucleotide binding] 358681014071 sequence specific DNA binding site [nucleotide binding]; other site 358681014072 putative cAMP binding site [chemical binding]; other site 358681014073 Nitrate/nitrite transporter [Inorganic ion transport and metabolism]; Region: NarK; COG2223 358681014074 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 358681014075 putative substrate translocation pore; other site 358681014076 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 358681014077 PAS domain; Region: PAS_9; pfam13426 358681014078 putative active site [active] 358681014079 heme pocket [chemical binding]; other site 358681014080 hydroxylamine reductase; Provisional; Region: PRK12310 358681014081 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 358681014082 ACS interaction site; other site 358681014083 CODH interaction site; other site 358681014084 metal cluster binding site [ion binding]; other site 358681014085 RNA polymerase sigma factor; Provisional; Region: PRK12543 358681014086 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 358681014087 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 358681014088 DNA binding residues [nucleotide binding] 358681014089 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4430 358681014090 Domain of unknown function (DU1801); Region: DUF1801; pfam08818 358681014091 Bacteriocin-protection, YdeI or OmpD-Associated; Region: OmdA; pfam13376 358681014092 Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531 358681014093 Family description; Region: VCBS; pfam13517 358681014094 Family description; Region: VCBS; pfam13517 358681014095 Family description; Region: VCBS; pfam13517 358681014096 Family description; Region: VCBS; pfam13517 358681014097 Family description; Region: VCBS; pfam13517 358681014098 Family description; Region: VCBS; pfam13517 358681014099 HYR domain; Region: HYR; pfam02494 358681014100 HYR domain; Region: HYR; pfam02494 358681014101 Ferrous iron transport protein B; Region: FeoB_N; pfam02421 358681014102 Sulfite oxidase and related enzymes [General function prediction only]; Region: COG2041 358681014103 bacterial and archael members of the sulfite oxidase (SO) family of molybdopterin binding domains. This molybdopterin cofactor (Moco) binding domain is found in a variety of oxidoreductases, main members of this family are nitrate reductase (NR) and...; Region: arch_bact_SO_family_Moco; cd02109 358681014104 Moco binding site; other site 358681014105 metal coordination site [ion binding]; other site 358681014106 Predicted CoA-binding protein [General function prediction only]; Region: COG1832 358681014107 multifunctional aminopeptidase A; Provisional; Region: PRK00913 358681014108 Cytosol aminopeptidase family, N-terminal and catalytic domains. Family M17 contains zinc- and manganese-dependent exopeptidases ( EC 3.4.11.1), including leucine aminopeptidase. They catalyze removal of amino acids from the N-terminus of a protein and...; Region: Peptidase_M17; cd00433 358681014109 interface (dimer of trimers) [polypeptide binding]; other site 358681014110 Substrate-binding/catalytic site; other site 358681014111 Zn-binding sites [ion binding]; other site 358681014112 Domain of unknown function (DUF309); Region: DUF309; pfam03745 358681014113 Divergent PAP2 family; Region: DUF212; pfam02681 358681014114 Cobalamin binding protein BtuF. These proteins have been shown to function as initial receptors in ABC transport of vitamin B12 (cobalamin) in eubacterial and some archaeal species. They belong to the TroA superfamily of helical backbone metal receptor...; Region: BtuF; cd01144 358681014115 Periplasmic binding protein; Region: Peripla_BP_2; pfam01497 358681014116 cobalamin binding residues [chemical binding]; other site 358681014117 putative BtuC binding residues; other site 358681014118 dimer interface [polypeptide binding]; other site 358681014119 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3584 358681014120 Putative membrane protein; Region: YuiB; pfam14068 358681014121 DnaJ-class molecular chaperone with C-terminal Zn finger domain [Posttranslational modification, protein turnover, chaperones]; Region: DnaJ; COG0484 358681014122 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cd02883 358681014123 nudix motif; other site 358681014124 NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252 358681014125 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 358681014126 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 358681014127 Thioredoxin reductase [Posttranslational modification, protein turnover, chaperones]; Region: TrxB; COG0492 358681014128 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 358681014129 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 358681014130 chaperone protein DnaK; Region: prok_dnaK; TIGR02350 358681014131 Nitrilase superfamily, including nitrile- or amide-hydrolyzing enzymes and amide-condensing enzymes; Region: nitrilase; cl11424 358681014132 Cupredoxin-like domain; Region: Cupredoxin_1; cl17234 358681014133 Bacillus subtilis YkuE and related proteins, C-terminal metallophosphatase domain; Region: MPP_YkuE_C; cd07385 358681014134 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 358681014135 putative active site [active] 358681014136 putative metal binding site [ion binding]; other site 358681014137 NTR_like domain; a beta barrel with an oligosaccharide/oligonucleotide-binding fold found in netrins, complement proteins, tissue inhibitors of metalloproteases (TIMP), and procollagen C-proteinase enhancers (PCOLCE), amongst others. In netrins, the...; Region: NTR_like; cl02512 358681014138 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 358681014139 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 358681014140 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 358681014141 DNA binding residues [nucleotide binding] 358681014142 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 358681014143 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 358681014144 Coenzyme A binding pocket [chemical binding]; other site 358681014145 Fe-S cluster assembly scaffold protein [Posttranslational modification, protein turnover, chaperones]; Region: sufA; COG0316 358681014146 putative menaquinone biosynthesis protein, SCO4494 family; Region: mena_SCO4494; TIGR03700 358681014147 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 358681014148 FeS/SAM binding site; other site 358681014149 hypothetical protein; Provisional; Region: PRK13669 358681014150 NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252 358681014151 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_18; cd04677 358681014152 nudix motif; other site 358681014153 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 358681014154 Predicted amidohydrolase [General function prediction only]; Region: COG0388 358681014155 Nitrilase superfamily, including nitrile- or amide-hydrolyzing enzymes and amide-condensing enzymes; Region: nitrilase; cd07197 358681014156 active site 358681014157 catalytic triad [active] 358681014158 dimer interface [polypeptide binding]; other site 358681014159 Domain of unknown function (DUF4343); Region: DUF4343; pfam14243 358681014160 Protein of unknown function (DUF1462); Region: DUF1462; pfam07315 358681014161 cystathionine beta-lyase; Provisional; Region: PRK07671 358681014162 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 358681014163 homodimer interface [polypeptide binding]; other site 358681014164 substrate-cofactor binding pocket; other site 358681014165 pyridoxal 5'-phosphate binding site [chemical binding]; other site 358681014166 catalytic residue [active] 358681014167 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 358681014168 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 358681014169 dimer interface [polypeptide binding]; other site 358681014170 pyridoxal 5'-phosphate binding site [chemical binding]; other site 358681014171 catalytic residue [active] 358681014172 NifU-like domain; Region: NifU; pfam01106 358681014173 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 358681014174 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 358681014175 glyoxylate reductase; Reviewed; Region: PRK13243 358681014176 D-glycerate dehydrogenase/hydroxypyruvate reductase (GDH); Region: GDH; cd05301 358681014177 dimerization interface [polypeptide binding]; other site 358681014178 ligand binding site [chemical binding]; other site 358681014179 NADP binding site [chemical binding]; other site 358681014180 catalytic site [active] 358681014181 spore coat protein YutH; Region: spore_yutH; TIGR02905 358681014182 spore coat protein, CotS family; Region: spore_CotS; TIGR02906 358681014183 Phosphatidylglycerophosphatase A; a bacterial membrane-associated enzyme involved in lipid metabolism; Region: PgpA; cd06971 358681014184 tetramer interfaces [polypeptide binding]; other site 358681014185 binuclear metal-binding site [ion binding]; other site 358681014186 HAD-superfamily subfamily IIA hydrolase, TIGR01457; Region: HAD-SF-IIA-hyp2 358681014187 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 358681014188 active site 358681014189 motif I; other site 358681014190 motif II; other site 358681014191 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 358681014192 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 358681014193 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 358681014194 active site 358681014195 metal binding site [ion binding]; metal-binding site 358681014196 Domain of unknown function (DUF4073); Region: DUF4073; pfam13285 358681014197 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 358681014198 Predicted transcriptional regulator [Transcription]; Region: COG2345 358681014199 putative DNA binding site [nucleotide binding]; other site 358681014200 putative Zn2+ binding site [ion binding]; other site 358681014201 V4R domain; Region: V4R; cl15268 358681014202 Uncharacterized conserved protein [Function unknown]; Region: COG2445 358681014203 Bacterial fructose-1,6-bisphosphatase, glpX-encoded. A dimeric enzyme dependent on Mg(2+). glpX-encoded FPBase (FBPase class II) differs from other members of the inositol-phosphatase superfamily by permutation of secondary structure elements. The core...; Region: FBPase_glpX; cd01516 358681014204 Bacterial fructose-1,6-bisphosphatase, glpX-encoded; Region: FBPase_glpX; pfam03320 358681014205 putative active site [active] 358681014206 Protein of unknown function (DUF3055); Region: DUF3055; pfam11256 358681014207 Protein of unknown function (DUF1027); Region: DUF1027; pfam06265 358681014208 Sporulation lipoprotein YhcN/YlaJ (Spore_YhcN_YlaJ); Region: Spore_YhcN_YlaJ; pfam09580 358681014209 lipoyl synthase; Provisional; Region: PRK05481 358681014210 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 358681014211 FeS/SAM binding site; other site 358681014212 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 358681014213 AAA domain; Region: AAA_23; pfam13476 358681014214 AAA domain; Region: AAA_21; pfam13304 358681014215 Walker A/P-loop; other site 358681014216 ATP binding site [chemical binding]; other site 358681014217 Mre11 nuclease, N-terminal metallophosphatase domain; Region: MPP_Mre11_N; cd00840 358681014218 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 358681014219 active site 358681014220 metal binding site [ion binding]; metal-binding site 358681014221 intracellular protease, PfpI family; Region: PfpI; TIGR01382 358681014222 Type 1 glutamine amidotransferase (GATase1)-like domain found in a subgroup of proteins similar to PfpI from Pyrococcus furiosus; Region: GATase1_PfpI_1; cd03169 358681014223 conserved cys residue [active] 358681014224 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 358681014225 Peptidase family M23; Region: Peptidase_M23; pfam01551 358681014226 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 358681014227 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 358681014228 Bacterial transcriptional repressor; Region: TetR_C_6; pfam13977 358681014229 Methylomonas sp. 4,4'-diapolycopene-dialdehyde dehydrogenase-like; Region: ALDH_DDALDH; cd07099 358681014230 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 358681014231 NAD(P) binding site [chemical binding]; other site 358681014232 catalytic residues [active] 358681014233 germination protein, Ger(x)C family; Region: spore_ger_x_C; TIGR02887 358681014234 Spore germination B3/ GerAC like, C-terminal; Region: Spore_GerAC; pfam05504 358681014235 Spore germination protein; Region: Spore_permease; cl17796 358681014236 Bacillus/Clostridium GerA spore germination protein; Region: GerA; pfam03323 358681014237 lumazine synthase (6,7-dimethyl-8-ribityllumazine synthase, LS), catalyzes the penultimate step in the biosynthesis of riboflavin (vitamin B2); type-I; Region: Lumazine_synthase-I; cd09209 358681014238 homopentamer interface [polypeptide binding]; other site 358681014239 active site 358681014240 bifunctional 3,4-dihydroxy-2-butanone 4-phosphate synthase/GTP cyclohydrolase II protein; Provisional; Region: PRK09311 358681014241 3,4-dihydroxy-2-butanone 4-phosphate synthase; Region: DHBP_synthase; pfam00926 358681014242 GTP cyclohydrolase II (RibA). GTP cyclohydrolase II catalyzes the conversion of GTP to 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5' phosphate, formate, pyrophosphate (APy), and GMP in the biosynthetic pathway of riboflavin. Riboflavin is the...; Region: GTP_cyclohydro2; cd00641 358681014243 dimerization interface [polypeptide binding]; other site 358681014244 active site 358681014245 riboflavin synthase subunit alpha; Provisional; Region: PRK09289 358681014246 Lumazine binding domain; Region: Lum_binding; pfam00677 358681014247 Lumazine binding domain; Region: Lum_binding; pfam00677 358681014248 riboflavin biosynthesis protein RibD; Region: eubact_ribD; TIGR00326 358681014249 Riboflavin-specific deaminase. Riboflavin biosynthesis protein RibD (Diaminohydroxyphosphoribosylaminopyrimidine deaminase) catalyzes the deamination of 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate, which is an intermediate step in the...; Region: Riboflavin_deaminase-reductase; cd01284 358681014250 catalytic motif [active] 358681014251 Zn binding site [ion binding]; other site 358681014252 RibD C-terminal domain; Region: RibD_C; cl17279 358681014253 Predicted phosphatases [General function prediction only]; Region: Gph; COG0546 358681014254 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cl17915 358681014255 motif II; other site 358681014256 Cytochrome c [Energy production and conversion]; Region: COG3258 358681014257 Cytochrome c; Region: Cytochrom_C; pfam00034 358681014258 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204 358681014259 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 358681014260 active site 358681014261 phosphorylation site [posttranslational modification] 358681014262 intermolecular recognition site; other site 358681014263 dimerization interface [polypeptide binding]; other site 358681014264 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 358681014265 Walker A motif; other site 358681014266 ATP binding site [chemical binding]; other site 358681014267 Walker B motif; other site 358681014268 arginine finger; other site 358681014269 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 358681014270 Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840 358681014271 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 358681014272 dimerization interface [polypeptide binding]; other site 358681014273 Signal transduction histidine kinase, nitrogen specific [Signal transduction mechanisms]; Region: NtrB; COG3852 358681014274 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 358681014275 phosphorylation site [posttranslational modification] 358681014276 dimer interface [polypeptide binding]; other site 358681014277 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 358681014278 ATP binding site [chemical binding]; other site 358681014279 G-X-G motif; other site 358681014280 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 358681014281 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 358681014282 Sporulation protein YunB (Spo_YunB); Region: Spore_YunB; cl09783 358681014283 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 358681014284 putative substrate translocation pore; other site 358681014285 Copper amine oxidase N-terminal domain; Region: Cu_amine_oxidN1; pfam07833 358681014286 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 358681014287 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 358681014288 protein binding site [polypeptide binding]; other site 358681014289 Cysteine dioxygenase type I; Region: CDO_I; pfam05995 358681014290 Globin domain present in Globin-Coupled-Sensors (GCS). These domains detect changes in intracellular concentrations of oxygen, carbon monoxyde, or nitrous oxide, which result in aerotaxis and/or gene regulation. One subgroup, the HemATs, are aerotactic...; Region: sensor_globin; cd01068 358681014291 heme-binding site [chemical binding]; other site 358681014292 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 358681014293 dimer interface [polypeptide binding]; other site 358681014294 putative CheW interface [polypeptide binding]; other site 358681014295 CorA-like Mg2+ transporter protein; Region: CorA; pfam01544 358681014296 Thermotoga maritima CorA-like family; Region: TmCorA-like; cd12822 358681014297 oligomer interface [polypeptide binding]; other site 358681014298 metal binding site [ion binding]; metal-binding site 358681014299 metal binding site [ion binding]; metal-binding site 358681014300 putative Cl binding site [ion binding]; other site 358681014301 aspartate ring; other site 358681014302 basic sphincter; other site 358681014303 hydrophobic gate; other site 358681014304 periplasmic entrance; other site 358681014305 c-di-GMP phosphodiesterase class II (HD-GYP domain) [Signal transduction mechanisms]; Region: COG2206 358681014306 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 358681014307 Zn2+ binding site [ion binding]; other site 358681014308 Mg2+ binding site [ion binding]; other site 358681014309 Protein of unknown function (DUF2804); Region: DUF2804; pfam10974 358681014310 Domain of unknown function (DUF1805); Region: DUF1805; cl01339 358681014311 NAD pyrophosphatase/5'-nucleotidase NadN; Region: nadN; TIGR01530 358681014312 Escherichia coli UshA-like family, N-terminal metallophosphatase domain; Region: MPP_UshA_N_like; cd00845 358681014313 active site 358681014314 metal binding site [ion binding]; metal-binding site 358681014315 5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872 358681014316 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 358681014317 Protein of unknown function DUF72; Region: DUF72; pfam01904 358681014318 Mpr1p, Pad1p N-terminal (MPN) domains with catalytic isopeptidase activity (metal-binding); Region: MPN_like; cd08070 358681014319 MPN+ (JAMM) motif; other site 358681014320 Zinc-binding site [ion binding]; other site 358681014321 aspartate kinase; Reviewed; Region: PRK09034 358681014322 AAK_AKiii-YclM-BS: Amino Acid Kinase Superfamily (AAK), AKiii-YclM-BS; this CD includes the N-terminal catalytic aspartokinase (AK) domain of the lysine plus threonine-sensitive aspartokinase isoenzyme AKIII, a monofunctional class enzyme found in...; Region: AAK_AKiii-YclM-BS; cd04245 358681014323 putative catalytic residues [active] 358681014324 putative nucleotide binding site [chemical binding]; other site 358681014325 putative aspartate binding site [chemical binding]; other site 358681014326 ACT domains located C-terminal to the catalytic domain of the lysine plus threonine-sensitive aspartokinase isoenzyme AKIII; Region: ACT_AKiii-YclM-BS_1; cd04911 358681014327 allosteric regulatory residue; other site 358681014328 ACT domains located C-terminal to the catalytic domain of the lysine plus threonine-sensitive aspartokinase isoenzyme AKIII; Region: ACT_AKiii-YclM-BS_2; cd04916 358681014329 Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726 358681014330 Catalytic NodB homology domain of rhizobial NodB-like proteins; Region: CE4_NodB_like_6s_7s; cd10917 358681014331 NodB motif; other site 358681014332 active site 358681014333 catalytic site [active] 358681014334 metal binding site [ion binding]; metal-binding site 358681014335 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2268 358681014336 Band_7_flotillin: a subgroup of the band 7 domain of flotillin (reggie) like proteins. This subgroup contains proteins similar to stomatin, prohibitin, flotillin, HlfK/C and podicin. These two proteins are lipid raft-associated. Individual proteins of...; Region: Band_7_flotillin; cd03399 358681014337 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 358681014338 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 358681014339 DNA-binding site [nucleotide binding]; DNA binding site 358681014340 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 358681014341 pyridoxal 5'-phosphate binding site [chemical binding]; other site 358681014342 homodimer interface [polypeptide binding]; other site 358681014343 catalytic residue [active] 358681014344 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 358681014345 EamA-like transporter family; Region: EamA; pfam00892 358681014346 EamA-like transporter family; Region: EamA; pfam00892 358681014347 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cd02883 358681014348 nudix motif; other site 358681014349 Suppressor of fused protein (SUFU); Region: SUFU; pfam05076 358681014350 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 358681014351 FtsX-like permease family; Region: FtsX; pfam02687 358681014352 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 358681014353 FtsX-like permease family; Region: FtsX; pfam02687 358681014354 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 358681014355 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 358681014356 Walker A/P-loop; other site 358681014357 ATP binding site [chemical binding]; other site 358681014358 Q-loop/lid; other site 358681014359 ABC transporter signature motif; other site 358681014360 Walker B; other site 358681014361 D-loop; other site 358681014362 H-loop/switch region; other site 358681014363 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 358681014364 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 358681014365 dimer interface [polypeptide binding]; other site 358681014366 phosphorylation site [posttranslational modification] 358681014367 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 358681014368 ATP binding site [chemical binding]; other site 358681014369 Mg2+ binding site [ion binding]; other site 358681014370 G-X-G motif; other site 358681014371 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 358681014372 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 358681014373 active site 358681014374 phosphorylation site [posttranslational modification] 358681014375 intermolecular recognition site; other site 358681014376 dimerization interface [polypeptide binding]; other site 358681014377 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 358681014378 DNA binding site [nucleotide binding] 358681014379 cysteine desulfurase activator complex subunit SufB; Provisional; Region: PRK11814; cl03223 358681014380 FeS assembly protein SufB; Region: sufB; TIGR01980 358681014381 NifU homolog involved in Fe-S cluster formation [Energy production and conversion]; Region: IscU; COG0822 358681014382 Iron-sulfur cluster scaffold-like proteins; Region: IscU_like; cd06664 358681014383 trimerization site [polypeptide binding]; other site 358681014384 active site 358681014385 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 358681014386 Cysteine desulfurase (SufS)-like. This family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to cysteine desulfurase (SufS) and selenocysteine lyase. SufS...; Region: SufS_like; cd06453 358681014387 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 358681014388 catalytic residue [active] 358681014389 Cysteine desulfurase activator SufB [Posttranslational modification, protein turnover, chaperones]; Region: SufB; COG0719 358681014390 FeS assembly protein SufD; Region: sufD; TIGR01981 358681014391 Cysteine desulfurase activator ATPase [Posttranslational modification, protein turnover, chaperones]; Region: sufC; COG0396 358681014392 ABC-type transport system involved in Fe-S cluster assembly, ATPase component; Region: ABC_FeS_Assembly; cd03217 358681014393 Walker A/P-loop; other site 358681014394 ATP binding site [chemical binding]; other site 358681014395 Q-loop/lid; other site 358681014396 ABC transporter signature motif; other site 358681014397 Walker B; other site 358681014398 D-loop; other site 358681014399 H-loop/switch region; other site 358681014400 Phosphoenolpyruvate carboxykinase; Region: PEPCK_ATP; pfam01293 358681014401 Phosphoenolpyruvate carboxykinase (PEPCK), a critical gluconeogenic enzyme, catalyzes the first committed step in the diversion of tricarboxylic acid cycle intermediates toward gluconeogenesis. It catalyzes the reversible decarboxylation and...; Region: PEPCK_ATP; cd00484 358681014402 active site 358681014403 substrate-binding site [chemical binding]; other site 358681014404 metal-binding site [ion binding] 358681014405 ATP binding site [chemical binding]; other site 358681014406 M20 Peptidase Aminoacylase 1 amhX_like subfamily; Region: M20_Acy1_amhX_like; cd08018 358681014407 amidohydrolase; Region: amidohydrolases; TIGR01891 358681014408 metal binding site [ion binding]; metal-binding site 358681014409 putative dimer interface [polypeptide binding]; other site 358681014410 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 358681014411 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 358681014412 active site 358681014413 metal binding site [ion binding]; metal-binding site 358681014414 Cache domain; Region: Cache_1; pfam02743 358681014415 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 358681014416 dimerization interface [polypeptide binding]; other site 358681014417 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 358681014418 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 358681014419 dimer interface [polypeptide binding]; other site 358681014420 putative CheW interface [polypeptide binding]; other site 358681014421 Glycine cleavage H-protein. Glycine cleavage H-proteins are part of the glycine cleavage system (GCS) found in bacteria, archea and the mitochondria of eukaryotes. GCS is a multienzyme complex consisting of 4 different components (P-, H-, T- and...; Region: GCS_H; cd06848 358681014422 lipoyl attachment site [posttranslational modification]; other site 358681014423 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 358681014424 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 358681014425 LL-diaminopimelate aminotransferase; Provisional; Region: PRK09276 358681014426 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 358681014427 pyridoxal 5'-phosphate binding site [chemical binding]; other site 358681014428 homodimer interface [polypeptide binding]; other site 358681014429 catalytic residue [active] 358681014430 Arsenate Reductase (ArsC) family, unknown subfamily; uncharacterized proteins containing a CXXC motif with similarity to thioredoxin (TRX)-fold arsenic reductases, ArsC. Proteins containing a redox active CXXC motif like TRX and glutaredoxin (GRX)...; Region: ArsC_like; cd03036 358681014431 ArsC family; Region: ArsC; pfam03960 358681014432 putative ArsC-like catalytic residues; other site 358681014433 putative TRX-like catalytic residues [active] 358681014434 Protein of unknown function (DUF2797); Region: DUF2797; pfam10977 358681014435 delta-lactam-biosynthetic de-N-acetylase; Region: spore_pdaA; TIGR02884 358681014436 Catalytic NodB homology domain of rhizobial NodB-like proteins; Region: CE4_NodB_like_6s_7s; cd10917 358681014437 NodB motif; other site 358681014438 active site 358681014439 catalytic site [active] 358681014440 metal binding site [ion binding]; metal-binding site 358681014441 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 358681014442 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 358681014443 Walker A/P-loop; other site 358681014444 ATP binding site [chemical binding]; other site 358681014445 Q-loop/lid; other site 358681014446 ABC transporter signature motif; other site 358681014447 Walker B; other site 358681014448 D-loop; other site 358681014449 H-loop/switch region; other site 358681014450 signal peptide peptidase SppA, 36K type; Region: SppA_dom; TIGR00706 358681014451 Signal peptide peptidase A (SppA), a serine protease, has catalytic Ser-Lys dyad; Region: S49_Sppa_N_C; cd07023 358681014452 tandem repeat interface [polypeptide binding]; other site 358681014453 oligomer interface [polypeptide binding]; other site 358681014454 active site residues [active] 358681014455 RDD family; Region: RDD; pfam06271 358681014456 Uncharacterized protein with SCP/PR1 domains [Function unknown]; Region: COG2340 358681014457 SCP_bacterial: SCP-like extracellular protein domain, as found in bacteria and archaea. The wider family of SCP containing proteins includes plant pathogenesis-related protein 1 (PR-1), CRISPs, mammalian cysteine-rich secretory proteins, and allergen 5...; Region: SCP_bacterial; cd05379 358681014458 putative transposase OrfB; Reviewed; Region: PHA02517 358681014459 HTH-like domain; Region: HTH_21; pfam13276 358681014460 Integrase core domain; Region: rve; pfam00665 358681014461 Integrase core domain; Region: rve_3; pfam13683 358681014462 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 358681014463 Transposase; Region: HTH_Tnp_1; pfam01527 358681014464 Domain of unknown function (DUF4280); Region: DUF4280; pfam14107 358681014465 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 358681014466 Major Facilitator Superfamily; Region: MFS_1; pfam07690 358681014467 putative substrate translocation pore; other site 358681014468 Major Facilitator Superfamily; Region: MFS_1; pfam07690 358681014469 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 358681014470 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 358681014471 ATP-binding cassette domain of glucan transporter and related proteins, subfamily C; Region: ABCC_Glucan_exporter_like; cd03254 358681014472 Walker A/P-loop; other site 358681014473 ATP binding site [chemical binding]; other site 358681014474 Q-loop/lid; other site 358681014475 ABC transporter signature motif; other site 358681014476 Walker B; other site 358681014477 D-loop; other site 358681014478 H-loop/switch region; other site 358681014479 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 358681014480 putative multidrug transporter membrane\ATP-binding components; Provisional; Region: PRK10789 358681014481 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 358681014482 Walker A/P-loop; other site 358681014483 ATP binding site [chemical binding]; other site 358681014484 Q-loop/lid; other site 358681014485 ABC transporter signature motif; other site 358681014486 Walker B; other site 358681014487 D-loop; other site 358681014488 H-loop/switch region; other site 358681014489 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 358681014490 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 358681014491 methylthioribose-1-phosphate isomerase; Reviewed; Region: mtnA; PRK05720 358681014492 S-methyl-5-thioribose-1-phosphate isomerase; Region: salvage_mtnA; TIGR00512 358681014493 methylthioribose kinase; Reviewed; Region: mtnK; PRK09550 358681014494 Phosphotransferase enzyme family; Region: APH; pfam01636 358681014495 Sigma factor regulator N-terminal; Region: Sigma_reg_N; pfam13800 358681014496 Sigma factor regulator C-terminal; Region: Sigma_reg_C; pfam13791 358681014497 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 358681014498 RNA polymerase sigma factor, SigM family; Region: SigM_subfam; TIGR02950 358681014499 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 358681014500 DNA binding residues [nucleotide binding] 358681014501 2,3-diketo-5-methylthiopentyl-1-phosphate enolase; Reviewed; Region: mtnW; PRK09549 358681014502 2,3-diketo-5-methylthiopentyl-1-phosphate enolase; Region: RLP_DK-MTP-1-P-enolase; cd08209 358681014503 dimer interface [polypeptide binding]; other site 358681014504 active site 358681014505 catalytic residue [active] 358681014506 metal binding site [ion binding]; metal-binding site 358681014507 2-hydroxy-3-keto-5-methylthiopentenyl-1-phosphate phosphatase; Reviewed; Region: mtnX; PRK09552 358681014508 haloacid dehalogenase-like hydrolase; Region: Hydrolase; pfam00702 358681014509 methylthioribulose-1-phosphate dehydratase; Reviewed; Region: mtnB; PRK06754 358681014510 intersubunit interface [polypeptide binding]; other site 358681014511 active site 358681014512 Zn2+ binding site [ion binding]; other site 358681014513 ARD/ARD' family; Region: ARD; pfam03079 358681014514 Cupin domain; Region: Cupin_2; pfam07883 358681014515 germination protein, Ger(x)C family; Region: spore_ger_x_C; TIGR02887 358681014516 Spore germination B3/ GerAC like, C-terminal; Region: Spore_GerAC; pfam05504 358681014517 Spore germination protein; Region: Spore_permease; cl17796 358681014518 Bacillus/Clostridium GerA spore germination protein; Region: GerA; pfam03323 358681014519 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 358681014520 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 358681014521 active site 358681014522 acetyl-CoA acetyltransferase; Provisional; Region: PRK07661 358681014523 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 358681014524 dimer interface [polypeptide binding]; other site 358681014525 active site 358681014526 3-hydroxyacyl-CoA dehydrogenase [Lipid metabolism]; Region: FadB; COG1250 358681014527 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 358681014528 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 358681014529 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 358681014530 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 358681014531 Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024 358681014532 substrate binding site [chemical binding]; other site 358681014533 oxyanion hole (OAH) forming residues; other site 358681014534 trimer interface [polypeptide binding]; other site 358681014535 S-layer homology domain; Region: SLH; pfam00395 358681014536 gamma-glutamyl kinase; Provisional; Region: PRK05429 358681014537 AAK_G5K_ProB: Glutamate-5-kinase (G5K) catalyzes glutamate-dependent ATP cleavage; G5K transfers the terminal phosphoryl group of ATP to the gamma-carboxyl group of glutamate, in the first and controlling step of proline (and, in mammals, ornithine)...; Region: AAK_G5K_ProB; cd04242 358681014538 nucleotide binding site [chemical binding]; other site 358681014539 homotetrameric interface [polypeptide binding]; other site 358681014540 putative phosphate binding site [ion binding]; other site 358681014541 putative allosteric binding site; other site 358681014542 PUA domain; Region: PUA; pfam01472 358681014543 Gamma-glutamyl phosphate reductase (GPR), aldehyde dehydrogenase families 18 and 19; Region: ALDH_F18-19_ProA-GPR; cd07079 358681014544 gamma-glutamyl phosphate reductase; Region: proA; TIGR00407 358681014545 putative catalytic cysteine [active] 358681014546 pyrroline-5-carboxylate reductase; Reviewed; Region: PRK11880 358681014547 NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; cl17232 358681014548 AAA domain; Region: AAA_17; pfam13207 358681014549 Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cd00657 358681014550 dinuclear metal binding motif [ion binding]; other site 358681014551 Coat F domain; Region: Coat_F; pfam07875 358681014552 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 358681014553 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 358681014554 DNA-binding site [nucleotide binding]; DNA binding site 358681014555 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 358681014556 pyridoxal 5'-phosphate binding site [chemical binding]; other site 358681014557 homodimer interface [polypeptide binding]; other site 358681014558 catalytic residue [active] 358681014559 Lysine efflux permease [General function prediction only]; Region: COG1279 358681014560 Phosphate transport regulator (distant homolog of PhoU) [Inorganic ion transport and metabolism]; Region: COG1392 358681014561 Phosphate/sulphate permeases [Inorganic ion transport and metabolism]; Region: PitA; COG0306 358681014562 Predicted transcriptional regulators [Transcription]; Region: COG1695 358681014563 Transcriptional regulator PadR-like family; Region: PadR; pfam03551 358681014564 DNA-directed RNA polymerase specialized sigma subunit, sigma24 homolog [Transcription]; Region: RpoE; COG1595 358681014565 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 358681014566 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 358681014567 DNA binding residues [nucleotide binding] 358681014568 Cupredoxin-like domain; Region: Cupredoxin_1; pfam13473 358681014569 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 358681014570 sugar efflux transporter; Region: 2A0120; TIGR00899 358681014571 putative substrate translocation pore; other site 358681014572 4-hydroxy-3-methylbut-2-enyl diphosphate reductase; Reviewed; Region: ispH; PRK01045 358681014573 4-Hydroxy-3-methylbut-2-enyl diphosphate reductase IspH [Lipid metabolism]; Region: lytB; COG0761 358681014574 2-dehydropantoate 2-reductase; Provisional; Region: PRK12921 358681014575 Ketopantoate reductase PanE/ApbA; Region: ApbA; pfam02558 358681014576 Ketopantoate reductase PanE/ApbA C terminal; Region: ApbA_C; pfam08546 358681014577 glutamine synthetase, type I; Region: GlnA; TIGR00653 358681014578 Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951 358681014579 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 358681014580 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 358681014581 Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376 358681014582 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 358681014583 putative septicolysin, cholesterol-dependent cytolysin family and related proteins; Region: septicolysin_like; cd12208 358681014584 oligomer interface [polypeptide binding]; other site 358681014585 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 358681014586 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 358681014587 Walker A/P-loop; other site 358681014588 ATP binding site [chemical binding]; other site 358681014589 Q-loop/lid; other site 358681014590 ABC transporter signature motif; other site 358681014591 Walker B; other site 358681014592 D-loop; other site 358681014593 H-loop/switch region; other site 358681014594 cobalt ABC transporter, permease protein CbiQ; Region: CbiQ_TIGR; TIGR02454 358681014595 cobalt transport protein CbiN; Provisional; Region: PRK02898 358681014596 cobalt transport protein CbiM; Validated; Region: PRK08319 358681014597 Cobalt uptake substrate-specific transmembrane region; Region: CbiM; pfam01891 358681014598 dihydroorotate dehydrogenase 2; Reviewed; Region: PRK05286 358681014599 Dihydroorotate dehydrogenase (DHOD) class 2. DHOD catalyzes the oxidation of (S)-dihydroorotate to orotate. This is the fourth step and the only redox reaction in the de novo biosynthesis of UMP, the precursor of all pyrimidine nucleotides. DHOD requires...; Region: DHOD_2_like; cd04738 358681014600 quinone interaction residues [chemical binding]; other site 358681014601 active site 358681014602 catalytic residues [active] 358681014603 FMN binding site [chemical binding]; other site 358681014604 substrate binding site [chemical binding]; other site 358681014605 Spore germination protein; Region: Spore_permease; cl17796 358681014606 Bacillus/Clostridium GerA spore germination protein; Region: GerA; pfam03323 358681014607 germination protein, Ger(x)C family; Region: spore_ger_x_C; TIGR02887 358681014608 Spore germination B3/ GerAC like, C-terminal; Region: Spore_GerAC; pfam05504 358681014609 Alanine dehydrogenase [Amino acid transport and metabolism]; Region: Ald; COG0686 358681014610 Alanine dehydrogenase NAD-binding and catalytic domains; Region: L-AlaDH; cd05305 358681014611 hexamer interface [polypeptide binding]; other site 358681014612 ligand binding site [chemical binding]; other site 358681014613 putative active site [active] 358681014614 NAD(P) binding site [chemical binding]; other site 358681014615 Regulator of polyketide synthase expression [Signal transduction mechanisms / Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2508 358681014616 PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556 358681014617 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 358681014618 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 358681014619 non-specific DNA binding site [nucleotide binding]; other site 358681014620 salt bridge; other site 358681014621 sequence-specific DNA binding site [nucleotide binding]; other site 358681014622 Cupin domain; Region: Cupin_2; pfam07883 358681014623 ornithine cyclodeaminase; Validated; Region: PRK08618 358681014624 ornithine cyclodeaminase; Validated; Region: PRK06823; cl17400 358681014625 Response regulator receiver domain; Region: Response_reg; pfam00072 358681014626 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 358681014627 active site 358681014628 phosphorylation site [posttranslational modification] 358681014629 intermolecular recognition site; other site 358681014630 dimerization interface [polypeptide binding]; other site 358681014631 Uncharacterized ABC-type transport system, periplasmic component/surface lipoprotein [General function prediction only]; Region: Med; COG1744 358681014632 Periplasmic binding component of a family of basic membrane lipoproteins from Borrelia and various putative lipoproteins from other bacteria; Region: PBP1_BmpA_like; cd06304 358681014633 ligand binding site [chemical binding]; other site 358681014634 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: VicK; COG5002 358681014635 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 358681014636 dimerization interface [polypeptide binding]; other site 358681014637 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 358681014638 dimer interface [polypeptide binding]; other site 358681014639 phosphorylation site [posttranslational modification] 358681014640 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 358681014641 ATP binding site [chemical binding]; other site 358681014642 Mg2+ binding site [ion binding]; other site 358681014643 G-X-G motif; other site 358681014644 Dienelactone hydrolase and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG0412 358681014645 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 358681014646 Transcriptional regulator [Transcription]; Region: LysR; COG0583 358681014647 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 358681014648 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 358681014649 dimerization interface [polypeptide binding]; other site 358681014650 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cl00125 358681014651 active site residue [active] 358681014652 hypothetical protein; Provisional; Region: PRK08582 358681014653 S1_RPS1_repeat_hs4: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_hs4; cd05692 358681014654 RNA binding site [nucleotide binding]; other site 358681014655 propionate/acetate kinase; Provisional; Region: PRK12379 358681014656 acetate kinase A/propionate kinase 2; Reviewed; Region: PRK00180 358681014657 VanZ like family; Region: VanZ; cl01971 358681014658 Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841 358681014659 Putative silver efflux pump [Inorganic ion transport and metabolism]; Region: COG3696 358681014660 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 358681014661 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 358681014662 Protein of unknown function (DUF2564); Region: DUF2564; pfam10819 358681014663 HlyD family secretion protein; Region: HlyD_3; pfam13437 358681014664 Acyl CoA:acetate/3-ketoacid CoA transferase, alpha subunit [Lipid metabolism]; Region: AtoD; COG1788 358681014665 3-oxoacid CoA-transferase, B subunit; Region: pcaJ_scoB_fam; TIGR02428 358681014666 Esterase/lipase [General function prediction only]; Region: COG1647 358681014667 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 358681014668 Major Facilitator Superfamily; Region: MFS_1; pfam07690 358681014669 putative substrate translocation pore; other site 358681014670 Transcriptional regulator [Transcription]; Region: LysR; COG0583 358681014671 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 358681014672 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 358681014673 dimerization interface [polypeptide binding]; other site 358681014674 formyltetrahydrofolate deformylase; Reviewed; Region: purU; PRK06027 358681014675 N-terminal ACT domain of formyltetrahydrofolate deformylase (F4HF-DF; formyltetrahydrofolate hydrolase); Region: ACT_F4HF-DF; cd04875 358681014676 Formyltetrahydrofolate deformylase (Formyl-FH4 hydrolase), C-terminal hydrolase domain; Region: FMT_core_Formyl-FH4-Hydrolase_C; cd08648 358681014677 putative active site [active] 358681014678 putative substrate binding site [chemical binding]; other site 358681014679 putative cosubstrate binding site; other site 358681014680 catalytic site [active] 358681014681 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 358681014682 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 358681014683 ABC-type Na+ efflux pump, permease component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatB; COG1668 358681014684 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 358681014685 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 358681014686 ABC-type Na+ transport system, ATPase component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatA; COG4555 358681014687 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 358681014688 Walker A/P-loop; other site 358681014689 ATP binding site [chemical binding]; other site 358681014690 Q-loop/lid; other site 358681014691 ABC transporter signature motif; other site 358681014692 Walker B; other site 358681014693 D-loop; other site 358681014694 H-loop/switch region; other site 358681014695 Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404 358681014696 putative efflux pump membrane fusion protein; Provisional; Region: PRK03598 358681014697 HlyD family secretion protein; Region: HlyD_3; pfam13437 358681014698 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 358681014699 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_16; cd07263 358681014700 DNA topoisomerase III; Provisional; Region: PRK07726 358681014701 TOPRIM_TopoIA_TopoIII: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to topoisomerase III. Type IA DNA topoisomerases remove (relax) negative supercoils in the DNA by: cleaving...; Region: TOPRIM_TopoIA_TopoIII; cd03362 358681014702 active site 358681014703 putative interdomain interaction site [polypeptide binding]; other site 358681014704 putative metal-binding site [ion binding]; other site 358681014705 putative nucleotide binding site [chemical binding]; other site 358681014706 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186 358681014707 domain I; other site 358681014708 DNA binding groove [nucleotide binding] 358681014709 phosphate binding site [ion binding]; other site 358681014710 domain II; other site 358681014711 domain III; other site 358681014712 nucleotide binding site [chemical binding]; other site 358681014713 catalytic site [active] 358681014714 domain IV; other site 358681014715 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 358681014716 Helix-Turn-Helix DNA binding domain of the transcription regulators TipAL, Mta, and SkgA; Region: HTH_TipAL-Mta; cd01106 358681014717 DNA binding residues [nucleotide binding] 358681014718 dimer interface [polypeptide binding]; other site 358681014719 Putative hydrophobic ligand-binding SRPBCC domain of an uncharacterized subgroup of CalC- and Aha1-like proteins; Region: SRPBCC_CalC_Aha1-like_7; cd08900 358681014720 putative hydrophobic ligand binding site [chemical binding]; other site 358681014721 methyl viologen resistance protein SmvA; Provisional; Region: PRK14995 358681014722 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 358681014723 putative substrate translocation pore; other site 358681014724 Bacterial Ig-like domain; Region: Big_5; pfam13205 358681014725 Bacterial Ig-like domain; Region: Big_5; pfam13205 358681014726 Protein of unknown function (DUF402); Region: DUF402; cl00979 358681014727 amino acid transporter; Region: 2A0306; TIGR00909 358681014728 C-terminus of AA_permease; Region: AA_permease_C; pfam13906 358681014729 Immunoglobulin-like fold, Plexins, Transcription factors (IPT). IPTs are also known as Transcription factor ImmunoGlobin (TIG) domains. They are present in intracellular transcription factors, cell surface receptors (such as plexins and scatter factor...; Region: IPT; cd00102 358681014730 Immunoglobulin-like fold, Plexins, Transcription factors (IPT). IPTs are also known as Transcription factor ImmunoGlobin (TIG) domains. They are present in intracellular transcription factors, cell surface receptors (such as plexins and scatter factor...; Region: IPT; cd00102 358681014731 Immunoglobulin-like fold, Plexins, Transcription factors (IPT). IPTs are also known as Transcription factor ImmunoGlobin (TIG) domains. They are present in intracellular transcription factors, cell surface receptors (such as plexins and scatter factor...; Region: IPT; cd00102 358681014732 Immunoglobulin-like fold, Plexins, Transcription factors (IPT). IPTs are also known as Transcription factor ImmunoGlobin (TIG) domains. They are present in intracellular transcription factors, cell surface receptors (such as plexins and scatter factor...; Region: IPT; cd00102 358681014733 Immunoglobulin-like fold, Plexins, Transcription factors (IPT). IPTs are also known as Transcription factor ImmunoGlobin (TIG) domains. They are present in intracellular transcription factors, cell surface receptors (such as plexins and scatter factor...; Region: IPT; cd00102 358681014734 Immunoglobulin-like fold, Plexins, Transcription factors (IPT). IPTs are also known as Transcription factor ImmunoGlobin (TIG) domains. They are present in intracellular transcription factors, cell surface receptors (such as plexins and scatter factor...; Region: IPT; cd00102 358681014735 Immunoglobulin-like fold, Plexins, Transcription factors (IPT). IPTs are also known as Transcription factor ImmunoGlobin (TIG) domains. They are present in intracellular transcription factors, cell surface receptors (such as plexins and scatter factor...; Region: IPT; cd00102 358681014736 Intradiol dioxygenases catalyze the critical ring-cleavage step in the conversion of catecholate derivatives to citric acid cycle intermediates. This family contains catechol 1,2-dioxygenases and protocatechuate 3,4-dioxygenases which are mononuclear...; Region: intradiol_dioxygenase; cl17208 358681014737 DinB family; Region: DinB; cl17821 358681014738 DinB superfamily; Region: DinB_2; pfam12867 358681014739 helicase-exonuclease AddAB, AddA subunit, Firmicutes type; Region: addA_Gpos; TIGR02785 358681014740 Part of AAA domain; Region: AAA_19; pfam13245 358681014741 Family description; Region: UvrD_C_2; pfam13538 358681014742 PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705 358681014743 helicase-exonuclease AddAB, AddB subunit; Region: addB_Gpos; TIGR02773 358681014744 PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705 358681014745 ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: SbcC; COG0419 358681014746 ATP-binding cassette domain of sbcCD; Region: ABC_sbcCD; cd03279 358681014747 Walker A/P-loop; other site 358681014748 ATP binding site [chemical binding]; other site 358681014749 Q-loop/lid; other site 358681014750 ABC transporter signature motif; other site 358681014751 ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: SbcC; COG0419 358681014752 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 358681014753 ABC transporter signature motif; other site 358681014754 Walker B; other site 358681014755 D-loop; other site 358681014756 H-loop/switch region; other site 358681014757 exonuclease SbcD; Region: sbcd; TIGR00619 358681014758 Type 5 capsule protein repressor C-terminal domain; Region: SbcD_C; pfam12320 358681014759 Uncharacterized protein required for cytochrome oxidase assembly [Posttranslational modification, protein turnover, chaperones]; Region: CtaA; COG1612 358681014760 Cytochrome oxidase assembly protein; Region: COX15-CtaA; pfam02628 358681014761 protoheme IX farnesyltransferase; Provisional; Region: PRK04375 358681014762 UbiA prenyltransferase family; Region: UbiA; pfam01040 358681014763 Protein of unknown function (DUF420); Region: DUF420; pfam04238 358681014764 Cytochrome c oxidase caa3 assembly factor (Caa3_CtaG); Region: Caa3_CtaG; cl09173 358681014765 succinic semialdehyde dehydrogenase; Region: PLN02278 358681014766 Mitochondrial succinate-semialdehyde dehydrogenase and ALDH family members 5A1 and 5F1-like; Region: ALDH_F5_SSADH_GabD; cd07103 358681014767 tetramerization interface [polypeptide binding]; other site 358681014768 NAD(P) binding site [chemical binding]; other site 358681014769 catalytic residues [active] 358681014770 Predicted metal-sulfur cluster biosynthetic enzyme [General function prediction only]; Region: PaaD; COG2151 358681014771 phenylacetate-CoA oxygenase, PaaJ subunit; Region: PA_CoA_Oxy4; TIGR02159 358681014772 Phenylacetic acid catabolic protein; Region: PaaA_PaaC; pfam05138 358681014773 Phenylacetic acid degradation B; Region: PaaB; cl01371 358681014774 phenylacetate-CoA oxygenase subunit PaaA; Provisional; Region: paaA; PRK13778 358681014775 phenylacetate-CoA oxygenase, PaaG subunit; Region: PA_CoA_Oxy1; TIGR02156 358681014776 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 358681014777 dimer interface [polypeptide binding]; other site 358681014778 putative CheW interface [polypeptide binding]; other site 358681014779 Periplasmic binding protein; Region: Peripla_BP_6; pfam13458 358681014780 Type I periplasmic binding component of ABC (ATPase Binding Cassette)-type transport systems that are predicted to be involved in uptake of amino acids; Region: PBP1_ABC-type_HAAT_like; cd06333 358681014781 putative ligand binding site [chemical binding]; other site 358681014782 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410 358681014783 ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224 358681014784 Walker A/P-loop; other site 358681014785 ATP binding site [chemical binding]; other site 358681014786 Q-loop/lid; other site 358681014787 ABC transporter signature motif; other site 358681014788 Walker B; other site 358681014789 D-loop; other site 358681014790 H-loop/switch region; other site 358681014791 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411 358681014792 ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219 358681014793 Walker A/P-loop; other site 358681014794 ATP binding site [chemical binding]; other site 358681014795 Q-loop/lid; other site 358681014796 ABC transporter signature motif; other site 358681014797 Walker B; other site 358681014798 D-loop; other site 358681014799 H-loop/switch region; other site 358681014800 ABC-type branched-chain amino acid transport system, permease component [Amino acid transport and metabolism]; Region: LivM; COG4177 358681014801 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 358681014802 TM-ABC transporter signature motif; other site 358681014803 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 358681014804 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 358681014805 TM-ABC transporter signature motif; other site 358681014806 PaaX-like protein; Region: PaaX; pfam07848 358681014807 phenylacetic acid degradation operon negative regulatory protein PaaX; Region: PaaX_trns_reg; TIGR02277 358681014808 PaaX-like protein C-terminal domain; Region: PaaX_C; pfam08223 358681014809 Predicted thioesterase [General function prediction only]; Region: COG5496 358681014810 putative acyltransferase; Provisional; Region: PRK05790 358681014811 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 358681014812 dimer interface [polypeptide binding]; other site 358681014813 active site 358681014814 putative acyltransferase; Provisional; Region: PRK05790 358681014815 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 358681014816 dimer interface [polypeptide binding]; other site 358681014817 active site 358681014818 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 358681014819 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 358681014820 3-hydroxyacyl-CoA dehydrogenase [Lipid metabolism]; Region: FadB; COG1250 358681014821 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 358681014822 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 358681014823 enoyl-CoA hydratase; Provisional; Region: PRK08140 358681014824 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 358681014825 substrate binding site [chemical binding]; other site 358681014826 oxyanion hole (OAH) forming residues; other site 358681014827 trimer interface [polypeptide binding]; other site 358681014828 enoyl-CoA hydratase; Provisional; Region: PRK05862 358681014829 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 358681014830 substrate binding site [chemical binding]; other site 358681014831 oxyanion hole (OAH) forming residues; other site 358681014832 trimer interface [polypeptide binding]; other site 358681014833 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 358681014834 phenylacetate-CoA ligase; Region: PA_CoA_ligase; TIGR02155 358681014835 acyl-activating enzyme (AAE) consensus motif; other site 358681014836 AMP binding site [chemical binding]; other site 358681014837 active site 358681014838 CoA binding site [chemical binding]; other site 358681014839 enoyl-CoA hydratase; Provisional; Region: PRK07657 358681014840 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 358681014841 substrate binding site [chemical binding]; other site 358681014842 oxyanion hole (OAH) forming residues; other site 358681014843 trimer interface [polypeptide binding]; other site 358681014844 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 358681014845 Thioesterase-like superfamily; Region: 4HBT_3; pfam13622 358681014846 CoenzymeA binding site [chemical binding]; other site 358681014847 subunit interaction site [polypeptide binding]; other site 358681014848 PHB binding site; other site 358681014849 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 358681014850 CoenzymeA binding site [chemical binding]; other site 358681014851 subunit interaction site [polypeptide binding]; other site 358681014852 PHB binding site; other site 358681014853 EthD domain; Region: EthD; cl17553 358681014854 Prokaryotic Cytochrome C oxidase subunit IV; Region: COX4_pro; cl01204 358681014855 Ubiquinol oxidase subunit III subfamily. Ubiquinol oxidase, the terminal oxidase in the respiratory chains of aerobic bacteria, is a multi-chain transmembrane protein located in the cell membrane. It catalyzes the reduction of O2 and simultaneously...; Region: Ubiquinol_oxidase_III; cd02863 358681014856 Subunit I/III interface [polypeptide binding]; other site 358681014857 Subunit III/IV interface [polypeptide binding]; other site 358681014858 Heme/copper-type cytochrome/quinol oxidases, subunit 1 [Energy production and conversion]; Region: CyoB; COG0843 358681014859 Ubiquinol oxidase subunit I. Ubiquinol oxidase, the terminal oxidase in the respiratory chains of aerobic bacteria, is a multi-chain transmembrane protein located in the cell membrane. It catalyzes the reduction of O2 and simultaneously pumps protons...; Region: Ubiquinol_Oxidase_I; cd01662 358681014860 D-pathway; other site 358681014861 Putative ubiquinol binding site [chemical binding]; other site 358681014862 Low-spin heme (heme b) binding site [chemical binding]; other site 358681014863 Putative water exit pathway; other site 358681014864 Binuclear center (heme o3/CuB) [ion binding]; other site 358681014865 K-pathway; other site 358681014866 Putative proton exit pathway; other site 358681014867 Heme/copper-type cytochrome/quinol oxidases, subunit 2 [Energy production and conversion]; Region: CyoA; COG1622 358681014868 Cytochrome C oxidase subunit II, transmembrane domain; Region: COX2_TM; pfam02790 358681014869 Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; pfam00116 358681014870 Cytochrome c; Region: Cytochrom_C; pfam00034 358681014871 short chain dehydrogenase; Provisional; Region: PRK06914 358681014872 17beta hydroxysteroid dehydrogenase-like, classical (c) SDRs; Region: 17beta-HSD-like_SDR_c; cd05374 358681014873 NADP binding site [chemical binding]; other site 358681014874 active site 358681014875 steroid binding site; other site 358681014876 germination protein, Ger(x)C family; Region: spore_ger_x_C; TIGR02887 358681014877 Spore germination B3/ GerAC like, C-terminal; Region: Spore_GerAC; pfam05504 358681014878 Bacillus/Clostridium GerA spore germination protein; Region: GerA; pfam03323 358681014879 SurA N-terminal domain; Region: SurA_N_3; cl07813 358681014880 ABC-type Na+ transport system, ATPase component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatA; COG4555 358681014881 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 358681014882 Walker A/P-loop; other site 358681014883 ATP binding site [chemical binding]; other site 358681014884 Q-loop/lid; other site 358681014885 ABC transporter signature motif; other site 358681014886 Walker B; other site 358681014887 D-loop; other site 358681014888 H-loop/switch region; other site 358681014889 Bacterial ABC transporter protein EcsB; Region: EcsB; pfam05975 358681014890 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 358681014891 dimerization interface [polypeptide binding]; other site 358681014892 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 358681014893 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 358681014894 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 358681014895 dimer interface [polypeptide binding]; other site 358681014896 putative CheW interface [polypeptide binding]; other site 358681014897 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 358681014898 S-adenosylmethionine binding site [chemical binding]; other site 358681014899 Putative multicopper oxidases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: SufI; COG2132 358681014900 Multicopper oxidase; Region: Cu-oxidase_3; pfam07732 358681014901 Multicopper oxidase; Region: Cu-oxidase; pfam00394 358681014902 Multicopper oxidase; Region: Cu-oxidase_2; pfam07731 358681014903 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198 358681014904 metal ion-dependent adhesion site (MIDAS); other site 358681014905 Protein of unknown function (DUF1355); Region: DUF1355; cl17712 358681014906 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057 358681014907 metal ion-dependent adhesion site (MIDAS); other site 358681014908 Protein of unknown function (DUF1355); Region: DUF1355; cl17712 358681014909 Aerotolerance regulator N-terminal; Region: BatA; pfam07584 358681014910 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198 358681014911 metal ion-dependent adhesion site (MIDAS); other site 358681014912 Protein of unknown function DUF58; Region: DUF58; pfam01882 358681014913 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057 358681014914 metal ion-dependent adhesion site (MIDAS); other site 358681014915 MoxR-like ATPases [General function prediction only]; Region: COG0714 358681014916 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 358681014917 Walker A motif; other site 358681014918 ATP binding site [chemical binding]; other site 358681014919 Walker B motif; other site 358681014920 arginine finger; other site 358681014921 cell envelope integrity inner membrane protein TolA; Provisional; Region: tolA; PRK09510 358681014922 ABC-2 family transporter protein; Region: ABC2_membrane_3; pfam12698 358681014923 ABC-2 family transporter protein; Region: ABC2_membrane_2; cl17866 358681014924 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 358681014925 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 358681014926 Walker A/P-loop; other site 358681014927 ATP binding site [chemical binding]; other site 358681014928 Q-loop/lid; other site 358681014929 ABC transporter signature motif; other site 358681014930 Walker B; other site 358681014931 D-loop; other site 358681014932 H-loop/switch region; other site 358681014933 Proline dehydrogenase; Region: Pro_dh; cl03282 358681014934 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 358681014935 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 358681014936 DNA-binding site [nucleotide binding]; DNA binding site 358681014937 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 358681014938 pyridoxal 5'-phosphate binding site [chemical binding]; other site 358681014939 homodimer interface [polypeptide binding]; other site 358681014940 catalytic residue [active] 358681014941 Glycerol-3-phosphate responsive antiterminator (mRNA-binding) [Transcription]; Region: GlpP; COG1954 358681014942 Glycerol-3-phosphate dehydrogenase [Energy production and conversion]; Region: GlpA; COG0578 358681014943 glycerol kinase; Provisional; Region: glpK; PRK00047 358681014944 Escherichia coli glycerol kinase-like proteins; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_EcGK_like; cd07786 358681014945 N- and C-terminal domain interface [polypeptide binding]; other site 358681014946 active site 358681014947 MgATP binding site [chemical binding]; other site 358681014948 catalytic site [active] 358681014949 metal binding site [ion binding]; metal-binding site 358681014950 glycerol binding site [chemical binding]; other site 358681014951 homotetramer interface [polypeptide binding]; other site 358681014952 homodimer interface [polypeptide binding]; other site 358681014953 FBP binding site [chemical binding]; other site 358681014954 protein IIAGlc interface [polypeptide binding]; other site 358681014955 Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane channels that selectively transport water, small neutral molecules, and ions out of and between cells. The channel proteins share a common fold: the N-terminal...; Region: MIP; cd00333 358681014956 amphipathic channel; other site 358681014957 Asn-Pro-Ala signature motifs; other site 358681014958 Membrane transporters of cations and cationic drugs [Inorganic ion transport and metabolism]; Region: EmrE; COG2076 358681014959 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 358681014960 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 358681014961 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 358681014962 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 358681014963 DNA-binding site [nucleotide binding]; DNA binding site 358681014964 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 358681014965 pyridoxal 5'-phosphate binding site [chemical binding]; other site 358681014966 homodimer interface [polypeptide binding]; other site 358681014967 catalytic residue [active] 358681014968 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 358681014969 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 358681014970 Erythromycin esterase; Region: Erythro_esteras; pfam05139 358681014971 Putative hydrophobic ligand-binding SRPBCC domain of Micromonospora echinospora CalC, human Aha1, and related proteins; Region: SRPBCC_CalC_Aha1-like; cd07814 358681014972 putative hydrophobic ligand binding site [chemical binding]; other site 358681014973 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 358681014974 dimerization interface [polypeptide binding]; other site 358681014975 putative DNA binding site [nucleotide binding]; other site 358681014976 putative Zn2+ binding site [ion binding]; other site 358681014977 DoxX-like family; Region: DoxX_2; pfam13564 358681014978 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 358681014979 Predicted exonuclease [DNA replication, recombination, and repair]; Region: COG3359 358681014980 RNase_H superfamily; Region: RNase_H_2; pfam13482 358681014981 helicase/secretion neighborhood putative DEAH-box helicase; Region: DECH_helic; TIGR03817 358681014982 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 358681014983 ATP binding site [chemical binding]; other site 358681014984 putative Mg++ binding site [ion binding]; other site 358681014985 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 358681014986 nucleotide binding region [chemical binding]; other site 358681014987 ATP-binding site [chemical binding]; other site 358681014988 Domain of unknown function (DUF1998); Region: DUF1998; pfam09369 358681014989 Spore germination protein; Region: Spore_permease; cl17796 358681014990 Bacillus/Clostridium GerA spore germination protein; Region: GerA; pfam03323 358681014991 germination protein, Ger(x)C family; Region: spore_ger_x_C; TIGR02887 358681014992 Spore germination B3/ GerAC like, C-terminal; Region: Spore_GerAC; pfam05504 358681014993 transcriptional repressor BetI; Region: betaine_BetI; TIGR03384 358681014994 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 358681014995 Bacterial transcriptional repressor; Region: TetR_C_6; pfam13977 358681014996 Protein of unknown function (DUF4241); Region: DUF4241; pfam14025 358681014997 bicupin, oxalate decarboxylase family; Region: bicupin_oxalic; TIGR03404 358681014998 Cupin; Region: Cupin_1; smart00835 358681014999 Cupin; Region: Cupin_1; smart00835 358681015000 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 358681015001 Major Facilitator Superfamily; Region: MFS_1; pfam07690 358681015002 putative substrate translocation pore; other site 358681015003 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 358681015004 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 358681015005 QacR-like protein, C-terminal region; Region: TetR_C_5; pfam08360 358681015006 Chromate transport protein ChrA [Inorganic ion transport and metabolism]; Region: ChrA; COG2059 358681015007 chromate transporter, chromate ion transporter (CHR) family; Region: 2A51; TIGR00937 358681015008 Chromate transporter; Region: Chromate_transp; pfam02417 358681015009 Putative metallopeptidase domain; Region: DUF2201_N; pfam13203 358681015010 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057 358681015011 metal ion-dependent adhesion site (MIDAS); other site 358681015012 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 358681015013 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 358681015014 Walker A motif; other site 358681015015 ATP binding site [chemical binding]; other site 358681015016 Walker B motif; other site 358681015017 arginine finger; other site 358681015018 von Willebrand factor; Region: vWF_A; pfam12450 358681015019 Uncharacterized protein containing a von Willebrand factor type A (vWA) domain [General function prediction only]; Region: COG2304 358681015020 VWA subgroup: Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b...; Region: vWA_subgroup; cd01465 358681015021 metal ion-dependent adhesion site (MIDAS); other site 358681015022 Domain of unknown function (DUF3520); Region: DUF3520; pfam12034 358681015023 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 358681015024 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 358681015025 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 358681015026 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 358681015027 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 358681015028 Bacterial transcription activator, effector binding domain; Region: AraC_E_bind; smart00871 358681015029 Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154 358681015030 Amidase; Region: Amidase; pfam01425 358681015031 Uncharacterized conserved protein [Function unknown]; Region: COG5361 358681015032 Protein of unknown function (DUF1254); Region: DUF1254; pfam06863 358681015033 Protein of unknown function (DUF1214); Region: DUF1214; cl08447 358681015034 ABC-type proline/glycine betaine transport systems, periplasmic components [Amino acid transport and metabolism]; Region: ProX; cl17891 358681015035 Substrate binding domain of ABC-type glycine betaine transport system; Region: OpuAC; pfam04069 358681015036 ABC-type proline/glycine betaine transport systems, periplasmic components [Amino acid transport and metabolism]; Region: ProX; cl17891 358681015037 Substrate binding domain of ABC-type glycine betaine transport system; Region: OpuAC; pfam04069 358681015038 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 358681015039 dimer interface [polypeptide binding]; other site 358681015040 conserved gate region; other site 358681015041 putative PBP binding loops; other site 358681015042 ABC-ATPase subunit interface; other site 358681015043 ABC-type proline/glycine betaine transport system, ATPase component [Amino acid transport and metabolism]; Region: ProV; COG4175 358681015044 ATP-binding cassette domain of the osmoprotectant proline/glycine betaine uptake system; Region: ABC_Pro_Gly_Betaine; cd03294 358681015045 Walker A/P-loop; other site 358681015046 ATP binding site [chemical binding]; other site 358681015047 Q-loop/lid; other site 358681015048 ABC transporter signature motif; other site 358681015049 Walker B; other site 358681015050 D-loop; other site 358681015051 H-loop/switch region; other site 358681015052 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in association with the ABC transporter OpuCA. OpuCA is the ATP binding component of a bacterial solute transporter that serves a protective role to cells growing...; Region: CBS_pair_ABC_OpuCA_assoc2; cd04583 358681015053 Predicted transcriptional regulators [Transcription]; Region: COG1510 358681015054 Isochorismatase family; Region: Isochorismatase; pfam00857 358681015055 Nicotinamidase_ related amidohydrolases. Cysteine hydrolases of unknown function that share the catalytic triad with other amidohydrolases, like nicotinamidase, which converts nicotinamide to nicotinic acid and ammonia; Region: nicotinamidase_related; cd01014 358681015056 catalytic triad [active] 358681015057 conserved cis-peptide bond; other site 358681015058 Uncharacterized conserved protein (DUF2196); Region: DUF2196; pfam09962 358681015059 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 358681015060 putative binding surface; other site 358681015061 active site 358681015062 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 358681015063 active site 358681015064 phosphorylation site [posttranslational modification] 358681015065 intermolecular recognition site; other site 358681015066 dimerization interface [polypeptide binding]; other site 358681015067 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 358681015068 metal binding site [ion binding]; metal-binding site 358681015069 active site 358681015070 I-site; other site 358681015071 Response regulator receiver domain; Region: Response_reg; pfam00072 358681015072 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 358681015073 active site 358681015074 phosphorylation site [posttranslational modification] 358681015075 intermolecular recognition site; other site 358681015076 dimerization interface [polypeptide binding]; other site 358681015077 Response regulator receiver domain; Region: Response_reg; pfam00072 358681015078 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 358681015079 active site 358681015080 phosphorylation site [posttranslational modification] 358681015081 intermolecular recognition site; other site 358681015082 dimerization interface [polypeptide binding]; other site 358681015083 HAMP domain; Region: HAMP; pfam00672 358681015084 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 358681015085 GAF domain; Region: GAF_3; pfam13492 358681015086 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 358681015087 dimer interface [polypeptide binding]; other site 358681015088 phosphorylation site [posttranslational modification] 358681015089 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 358681015090 ATP binding site [chemical binding]; other site 358681015091 Mg2+ binding site [ion binding]; other site 358681015092 G-X-G motif; other site 358681015093 Response regulator receiver domain; Region: Response_reg; pfam00072 358681015094 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 358681015095 active site 358681015096 phosphorylation site [posttranslational modification] 358681015097 intermolecular recognition site; other site 358681015098 dimerization interface [polypeptide binding]; other site 358681015099 Cold-inducible protein YdjO; Region: YdjO; pfam14169 358681015100 Acyltransferase family; Region: Acyl_transf_3; pfam01757 358681015101 Histidine kinase N terminal; Region: HisK_N; pfam09385 358681015102 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 358681015103 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 358681015104 dimer interface [polypeptide binding]; other site 358681015105 phosphorylation site [posttranslational modification] 358681015106 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 358681015107 ATP binding site [chemical binding]; other site 358681015108 Mg2+ binding site [ion binding]; other site 358681015109 G-X-G motif; other site 358681015110 Protein of unknown function (DUF1062); Region: DUF1062; cl01786 358681015111 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 358681015112 RNA binding surface [nucleotide binding]; other site 358681015113 Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583 358681015114 amidase catalytic site [active] 358681015115 Zn binding residues [ion binding]; other site 358681015116 substrate binding site [chemical binding]; other site 358681015117 Copper amine oxidase N-terminal domain; Region: Cu_amine_oxidN1; pfam07833 358681015118 Holin family; Region: Phage_holin_4; cl01989 358681015119 Uncharacterized protein conserved in bacteria (DUF2313); Region: DUF2313; cl01542 358681015120 Baseplate J-like protein; Region: Baseplate_J; pfam04865 358681015121 Protein of unknown function (DUF2634); Region: DUF2634; pfam10934 358681015122 Phage tail sheath protein; Region: Phage_sheath_1; pfam04984 358681015123 response regulator FixJ; Provisional; Region: fixJ; PRK09390 358681015124 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 358681015125 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cl17257 358681015126 DinB family; Region: DinB; cl17821 358681015127 DinB superfamily; Region: DinB_2; pfam12867 358681015128 Methyladenine glycosylase; Region: Adenine_glyco; pfam03352 358681015129 Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086 358681015130 active site 358681015131 Predicted membrane protein (DUF2085); Region: DUF2085; pfam09858 358681015132 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 358681015133 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 358681015134 TM-ABC transporter signature motif; other site 358681015135 ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129 358681015136 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 358681015137 Walker A/P-loop; other site 358681015138 ATP binding site [chemical binding]; other site 358681015139 Q-loop/lid; other site 358681015140 ABC transporter signature motif; other site 358681015141 Walker B; other site 358681015142 D-loop; other site 358681015143 H-loop/switch region; other site 358681015144 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 358681015145 Methylthioribose-binding protein-like of ABC-type transport systems that belong to a family of pentose/hexose sugar-binding proteins of the type I periplasmic binding protein (PBP1) superfamily; Region: PBP1_methylthioribose_binding_like; cd06305 358681015146 Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407 358681015147 putative ligand binding site [chemical binding]; other site 358681015148 5TMR of 5TMR-LYT; Region: 5TM-5TMR_LYT; pfam07694 358681015149 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 358681015150 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 358681015151 dimer interface [polypeptide binding]; other site 358681015152 phosphorylation site [posttranslational modification] 358681015153 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 358681015154 ATP binding site [chemical binding]; other site 358681015155 Mg2+ binding site [ion binding]; other site 358681015156 G-X-G motif; other site 358681015157 Predicted membrane protein [Function unknown]; Region: COG2323 358681015158 DNA-directed RNA polymerase specialized sigma subunit, sigma24 homolog [Transcription]; Region: RpoE; COG1595 358681015159 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 358681015160 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 358681015161 DNA binding residues [nucleotide binding] 358681015162 helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346 358681015163 Transcriptional regulator [Transcription]; Region: IclR; COG1414 358681015164 Bacterial transcriptional regulator; Region: IclR; pfam01614 358681015165 N-Dimethylarginine dimethylaminohydrolase [Amino acid transport and metabolism]; Region: COG1834 358681015166 Amidinotransferase; Region: Amidinotransf; pfam02274 358681015167 FeoA domain; Region: FeoA; pfam04023 358681015168 Ferrous iron transport protein B; Region: FeoB_N; pfam02421 358681015169 Ferrous iron transport protein B (FeoB) family; Region: FeoB; cd01879 358681015170 G1 box; other site 358681015171 GTP/Mg2+ binding site [chemical binding]; other site 358681015172 Switch I region; other site 358681015173 G2 box; other site 358681015174 G3 box; other site 358681015175 Switch II region; other site 358681015176 G4 box; other site 358681015177 G5 box; other site 358681015178 Fe2+ transport system protein B [Inorganic ion transport and metabolism]; Region: FeoB; COG0370 358681015179 Nucleoside recognition; Region: Gate; pfam07670 358681015180 Ferrous iron transport protein B C terminus; Region: FeoB_C; pfam07664 358681015181 Nucleoside recognition; Region: Gate; pfam07670 358681015182 RNA polymerase factor sigma C; Reviewed; Region: PRK09415 358681015183 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 358681015184 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 358681015185 DNA binding residues [nucleotide binding] 358681015186 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 358681015187 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 358681015188 Coenzyme A binding pocket [chemical binding]; other site 358681015189 SMI1 / KNR4 family (SUKH-1); Region: SMI1_KNR4; pfam09346 358681015190 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 358681015191 catalytic core [active] 358681015192 Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840 358681015193 HAMP domain; Region: HAMP; pfam00672 358681015194 dimerization interface [polypeptide binding]; other site 358681015195 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 358681015196 dimer interface [polypeptide binding]; other site 358681015197 putative CheW interface [polypeptide binding]; other site 358681015198 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 358681015199 The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504 358681015200 peptide binding site [polypeptide binding]; other site 358681015201 potential frameshift: common BLAST hit: gi|219667837|ref|YP_002458272.1| ATPase associated with various cellular activities AAA_5 358681015202 norD type: Denitrifying bacteria contain both membrane bound and periplasmic nitrate reductases. Denitrification plays a major role in completing the nitrogen cycle by converting nitrate or nitrite to nitrogen gas. The pathway for microbial...; Region: vWA_norD_type; cd01454 358681015203 metal ion-dependent adhesion site (MIDAS); other site 358681015204 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189 358681015205 gas vesicle protein GvpN; Region: gas_vesic_GvpN; TIGR02640 358681015206 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189 358681015207 H+ Antiporter protein; Region: 2A0121; TIGR00900 358681015208 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 358681015209 putative substrate translocation pore; other site 358681015210 GIY-YIG domain of LuxR and ArsR family transcriptional regulators, and uncharacterized hypothetical proteins found in bacteria; Region: GIY-YIG_LuxR_like; cd10451 358681015211 GIY-YIG motif/motif A; other site 358681015212 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 358681015213 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 358681015214 Coenzyme A binding pocket [chemical binding]; other site 358681015215 L-alanine-DL-glutamate epimerase and related enzymes of enolase superfamily [Cell envelope biogenesis, outer membrane / General function prediction only]; Region: COG4948 358681015216 L-Ala-D/L-Glu epimerase catalyzes the epimerization of L-Ala-D/L-Glu and other dipeptides. The genomic context and the substrate specificity of characterized members of this family from E.coli and B.subtilis indicates a possible role in the metabolism of...; Region: L-Ala-DL-Glu_epimerase; cd03319 358681015217 active site 358681015218 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 358681015219 Beta-lactamase; Region: Beta-lactamase; pfam00144 358681015220 Domain of unknown function (DUF3471); Region: DUF3471; pfam11954 358681015221 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 358681015222 outer membrane lipoprotein; Reviewed; Region: rcsF; PRK10781 358681015223 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_15; cd08492 358681015224 Response regulator of citrate/malate metabolism [Transcription / Signal transduction mechanisms]; Region: CitB; COG4565 358681015225 Zn-dependent dipeptidase, microsomal dipeptidase homolog [Amino acid transport and metabolism]; Region: COG2355 358681015226 renal dipeptidase (rDP), best studied in mammals and also called membrane or microsomal dipeptidase, is a membrane-bound glycoprotein hydrolyzing dipeptides and is involved in hydrolytic metabolism of penem and carbapenem beta-lactam antibiotics; Region: rDP_like; cd01301 358681015227 active site 358681015228 dimer interface [polypeptide binding]; other site 358681015229 Thermophilic metalloprotease (M29); Region: Peptidase_M29; pfam02073 358681015230 Leucyl aminopeptidase (aminopeptidase T) [Amino acid transport and metabolism]; Region: AmpS; COG2309 358681015231 dipeptide transporter ATP-binding subunit; Provisional; Region: dppF; PRK11308 358681015232 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 358681015233 Walker A/P-loop; other site 358681015234 ATP binding site [chemical binding]; other site 358681015235 Q-loop/lid; other site 358681015236 ABC transporter signature motif; other site 358681015237 Walker B; other site 358681015238 D-loop; other site 358681015239 H-loop/switch region; other site 358681015240 oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727 358681015241 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 358681015242 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 358681015243 Walker A/P-loop; other site 358681015244 ATP binding site [chemical binding]; other site 358681015245 Q-loop/lid; other site 358681015246 ABC transporter signature motif; other site 358681015247 Walker B; other site 358681015248 D-loop; other site 358681015249 H-loop/switch region; other site 358681015250 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 358681015251 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 358681015252 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 358681015253 dimer interface [polypeptide binding]; other site 358681015254 conserved gate region; other site 358681015255 putative PBP binding loops; other site 358681015256 ABC-ATPase subunit interface; other site 358681015257 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 358681015258 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 358681015259 dimer interface [polypeptide binding]; other site 358681015260 conserved gate region; other site 358681015261 ABC-ATPase subunit interface; other site 358681015262 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 358681015263 NAD dependent epimerase/dehydratase family; Region: Epimerase; pfam01370 358681015264 NAD(P) binding site [chemical binding]; other site 358681015265 active site 358681015266 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 358681015267 Serine hydrolase; Region: Ser_hydrolase; cl17834 358681015268 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 358681015269 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 358681015270 YsiA-like protein, C-terminal region; Region: TetR_C_4; pfam08359 358681015271 Protein of unknown function (DUF2785); Region: DUF2785; pfam10978 358681015272 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 358681015273 Novel bacterial esterase that cleaves esters on halogenated cyclic compounds; Region: Esterase_713_like; cl17303 358681015274 catalytic site [active] 358681015275 Domain of unknown function (DUF4272); Region: DUF4272; pfam14094 358681015276 Suppressor of fused protein (SUFU); Region: SUFU; pfam05076 358681015277 M6 family metalloprotease domain; Region: M6dom_TIGR03296 358681015278 F5/8 type C domain; Region: F5_F8_type_C; pfam00754 358681015279 sugar binding site [chemical binding]; other site 358681015280 Transcriptional activator of acetoin/glycerol metabolism [Secondary metabolites biosynthesis, transport, and catabolism / Transcription]; Region: AcoR; COG3284 358681015281 GAF domain; Region: GAF; pfam01590 358681015282 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 358681015283 Walker A motif; other site 358681015284 ATP binding site [chemical binding]; other site 358681015285 Walker B motif; other site 358681015286 arginine finger; other site 358681015287 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 358681015288 dihydrolipoamide dehydrogenase; Validated; Region: acoL; PRK06912 358681015289 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 358681015290 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 358681015291 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 358681015292 branched-chain alpha-keto acid dehydrogenase subunit E2; Reviewed; Region: PRK11856 358681015293 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 358681015294 E3 interaction surface; other site 358681015295 lipoyl attachment site [posttranslational modification]; other site 358681015296 e3 binding domain; Region: E3_binding; pfam02817 358681015297 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 358681015298 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit [Energy production and conversion]; Region: AcoB; COG0022 358681015299 Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036 358681015300 alpha subunit interface [polypeptide binding]; other site 358681015301 TPP binding site [chemical binding]; other site 358681015302 heterodimer interface [polypeptide binding]; other site 358681015303 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 358681015304 pyruvate dehydrogenase E1 component, alpha subunit; Region: PDH_E1_alph_y; TIGR03182 358681015305 Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000 358681015306 tetramer interface [polypeptide binding]; other site 358681015307 TPP-binding site [chemical binding]; other site 358681015308 heterodimer interface [polypeptide binding]; other site 358681015309 phosphorylation loop region [posttranslational modification] 358681015310 Predicted transcriptional regulators [Transcription]; Region: COG1733 358681015311 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 358681015312 NAD(P)H:FMN oxidoreductase family. This domain catalyzes the reduction of flavin, nitrocompound, quinones and azo compounds using NADH or NADPH as an electron donor. The enzyme is a homodimer, and each monomer binds a FMN as co-factor. This family...; Region: NfsB_like_nitroreductase; cd02149 358681015313 dimer interface [polypeptide binding]; other site 358681015314 FMN binding site [chemical binding]; other site 358681015315 hypothetical protein; Provisional; Region: PRK06194 358681015316 classical (c) SDRs; Region: SDR_c; cd05233 358681015317 NAD(P) binding site [chemical binding]; other site 358681015318 active site 358681015319 Predicted small integral membrane protein (DUF2165); Region: DUF2165; cl02290 358681015320 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 358681015321 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 358681015322 DNA-binding site [nucleotide binding]; DNA binding site 358681015323 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 358681015324 pyridoxal 5'-phosphate binding site [chemical binding]; other site 358681015325 homodimer interface [polypeptide binding]; other site 358681015326 catalytic residue [active] 358681015327 Nitrilases, cyanide hydratase (CH)s, and similar proteins (class 1 nitrilases); Region: nitrilases_CHs; cd07564 358681015328 Predicted amidohydrolase [General function prediction only]; Region: COG0388 358681015329 putative active site [active] 358681015330 catalytic triad [active] 358681015331 putative dimer interface [polypeptide binding]; other site 358681015332 Uncharacterized protein SCO1/SenC/PrrC, involved in biogenesis of respiratory and photosynthetic systems [General function prediction only]; Region: COG1999 358681015333 SCO (an acronym for Synthesis of Cytochrome c Oxidase) family; composed of proteins similar to Sco1, a membrane-anchored protein possessing a soluble domain with a TRX fold. Members of this family are required for the proper assembly of cytochrome c...; Region: SCO; cd02968 358681015334 Cu(I) binding site [ion binding]; other site 358681015335 Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010 358681015336 Cytochrome C oxidase, cbb3-type, subunit III; Region: Cytochrome_CBB3; pfam13442 358681015337 Heme/copper-type cytochrome/quinol oxidase, subunit 4 [Energy production and conversion]; Region: CyoD; COG3125 358681015338 Ubiquinol oxidase subunit III subfamily. Ubiquinol oxidase, the terminal oxidase in the respiratory chains of aerobic bacteria, is a multi-chain transmembrane protein located in the cell membrane. It catalyzes the reduction of O2 and simultaneously...; Region: Ubiquinol_oxidase_III; cd02863 358681015339 Subunit I/III interface [polypeptide binding]; other site 358681015340 Subunit III/IV interface [polypeptide binding]; other site 358681015341 Heme/copper-type cytochrome/quinol oxidases, subunit 1 [Energy production and conversion]; Region: CyoB; COG0843 358681015342 Ubiquinol oxidase subunit I. Ubiquinol oxidase, the terminal oxidase in the respiratory chains of aerobic bacteria, is a multi-chain transmembrane protein located in the cell membrane. It catalyzes the reduction of O2 and simultaneously pumps protons...; Region: Ubiquinol_Oxidase_I; cd01662 358681015343 D-pathway; other site 358681015344 Putative ubiquinol binding site [chemical binding]; other site 358681015345 Low-spin heme (heme b) binding site [chemical binding]; other site 358681015346 Putative water exit pathway; other site 358681015347 Binuclear center (heme o3/CuB) [ion binding]; other site 358681015348 K-pathway; other site 358681015349 Putative proton exit pathway; other site 358681015350 cytochrome o ubiquinol oxidase subunit II; Region: CyoA; TIGR01433 358681015351 Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; pfam00116 358681015352 COX Aromatic Rich Motif; Region: COX_ARM; pfam06481 358681015353 Arginine/lysine/ornithine decarboxylases [Amino acid transport and metabolism]; Region: LdcC; COG1982 358681015354 Ornithine decarboxylase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to ornithine decarboxylase (ODC), arginine decarboxylase (ADC) and lysine...; Region: Orn_deC_like; cd00615 358681015355 homodimer interface [polypeptide binding]; other site 358681015356 pyridoxal 5'-phosphate binding site [chemical binding]; other site 358681015357 catalytic residue [active] 358681015358 Orn/Lys/Arg decarboxylase, C-terminal domain; Region: OKR_DC_1_C; pfam03711 358681015359 Major Facilitator Superfamily; Region: MFS_1; pfam07690 358681015360 dipeptide transporter ATP-binding subunit; Provisional; Region: dppF; PRK11308 358681015361 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 358681015362 Walker A/P-loop; other site 358681015363 ATP binding site [chemical binding]; other site 358681015364 Q-loop/lid; other site 358681015365 ABC transporter signature motif; other site 358681015366 Walker B; other site 358681015367 D-loop; other site 358681015368 H-loop/switch region; other site 358681015369 oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727 358681015370 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 358681015371 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 358681015372 Walker A/P-loop; other site 358681015373 ATP binding site [chemical binding]; other site 358681015374 Q-loop/lid; other site 358681015375 ABC transporter signature motif; other site 358681015376 Walker B; other site 358681015377 D-loop; other site 358681015378 H-loop/switch region; other site 358681015379 oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727 358681015380 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 358681015381 N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911 358681015382 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 358681015383 dimer interface [polypeptide binding]; other site 358681015384 conserved gate region; other site 358681015385 putative PBP binding loops; other site 358681015386 ABC-ATPase subunit interface; other site 358681015387 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 358681015388 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 358681015389 dimer interface [polypeptide binding]; other site 358681015390 conserved gate region; other site 358681015391 putative PBP binding loops; other site 358681015392 ABC-ATPase subunit interface; other site 358681015393 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 358681015394 The substrate-binding component of the oligopeptide-binding protein, AppA, from Bacillus subtilis contains the type 2 periplasmic-binding fold; Region: PBP2_AppA_like; cd08514 358681015395 peptide binding site [polypeptide binding]; other site 358681015396 Beta-eliminating lyase; Region: Beta_elim_lyase; pfam01212 358681015397 Low-specificity threonine aldolase (TA). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). TA catalyzes the conversion of L-threonine or L-allo-threonine to glycine and acetaldehyde in a...; Region: TA_like; cd06502 358681015398 tetramer interface [polypeptide binding]; other site 358681015399 pyridoxal 5'-phosphate binding site [chemical binding]; other site 358681015400 catalytic residue [active] 358681015401 ATP-grasp domain; Region: ATP-grasp_4; pfam13535 358681015402 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 358681015403 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 358681015404 dimer interface [polypeptide binding]; other site 358681015405 pyridoxal 5'-phosphate binding site [chemical binding]; other site 358681015406 catalytic residue [active] 358681015407 argininosuccinate lyase; Region: argH; TIGR00838 358681015408 Lyase class I_like superfamily: contains the lyase class I family, histidine ammonia-lyase and phenylalanine ammonia-lyase, which catalyze similar beta-elimination reactions; Region: Lyase_I_like; cl00013 358681015409 tetramer interface [polypeptide binding]; other site 358681015410 H+ Antiporter protein; Region: 2A0121; TIGR00900 358681015411 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 358681015412 putative substrate translocation pore; other site 358681015413 Protein involved in propanediol utilization, and related proteins (includes coumermycin biosynthetic protein), possible kinase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: PduX; COG4542 358681015414 Condensation domain; Region: Condensation; pfam00668 358681015415 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 358681015416 amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733 358681015417 acyl-activating enzyme (AAE) consensus motif; other site 358681015418 AMP binding site [chemical binding]; other site 358681015419 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 358681015420 Condensation domain; Region: Condensation; pfam00668 358681015421 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 358681015422 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 358681015423 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 358681015424 acyl-activating enzyme (AAE) consensus motif; other site 358681015425 AMP binding site [chemical binding]; other site 358681015426 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 358681015427 Condensation domain; Region: Condensation; pfam00668 358681015428 non-ribosomal peptide synthase domain TIGR01720; Region: NRPS-para261 358681015429 Beta-lactamase; Region: Beta-lactamase; pfam00144 358681015430 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 358681015431 Condensation domain; Region: Condensation; pfam00668 358681015432 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 358681015433 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 358681015434 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 358681015435 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 358681015436 potential frameshift: common BLAST hit: gi|218235214|ref|YP_002367179.1| bacitracin synthetase 1 358681015437 The adenylation domain of nonribosomal peptide synthetases (NRPS), including Bacillus subtilis termination module Surfactin (SrfA-C); Region: A_NRPS_Srf_like; cd12117 358681015438 amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733 358681015439 acyl-activating enzyme (AAE) consensus motif; other site 358681015440 AMP binding site [chemical binding]; other site 358681015441 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 358681015442 Condensation domain; Region: Condensation; pfam00668 358681015443 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 358681015444 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 358681015445 The adenylation domain of nonribosomal peptide synthetases (NRPS), including Bacillus subtilis termination module Surfactin (SrfA-C); Region: A_NRPS_Srf_like; cd12117 358681015446 acyl-activating enzyme (AAE) consensus motif; other site 358681015447 AMP binding site [chemical binding]; other site 358681015448 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 358681015449 Condensation domain; Region: Condensation; pfam00668 358681015450 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 358681015451 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 358681015452 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 358681015453 acyl-activating enzyme (AAE) consensus motif; other site 358681015454 AMP binding site [chemical binding]; other site 358681015455 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 358681015456 Condensation domain; Region: Condensation; pfam00668 358681015457 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 358681015458 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 358681015459 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 358681015460 amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733 358681015461 acyl-activating enzyme (AAE) consensus motif; other site 358681015462 AMP binding site [chemical binding]; other site 358681015463 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 358681015464 Condensation domain; Region: Condensation; pfam00668 358681015465 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 358681015466 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 358681015467 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 358681015468 acyl-activating enzyme (AAE) consensus motif; other site 358681015469 AMP binding site [chemical binding]; other site 358681015470 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 358681015471 Condensation domain; Region: Condensation; pfam00668 358681015472 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 358681015473 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 358681015474 Cadherin tandem repeat domain; Region: Cadherin_repeat; cd11304 358681015475 Ca2+ binding site [ion binding]; other site 358681015476 Bacterial surface proteins containing Ig-like domains [Cell motility and secretion]; Region: COG5492 358681015477 Bacterial Ig-like domain (group 2); Region: Big_2; pfam02368 358681015478 Bacterial Ig-like domain (group 2); Region: Big_2; cl02708 358681015479 Bacterial Ig-like domain (group 2); Region: Big_2; cl02708 358681015480 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 358681015481 dimerization interface [polypeptide binding]; other site 358681015482 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 358681015483 dimer interface [polypeptide binding]; other site 358681015484 phosphorylation site [posttranslational modification] 358681015485 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 358681015486 ATP binding site [chemical binding]; other site 358681015487 Mg2+ binding site [ion binding]; other site 358681015488 G-X-G motif; other site 358681015489 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 358681015490 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 358681015491 active site 358681015492 phosphorylation site [posttranslational modification] 358681015493 intermolecular recognition site; other site 358681015494 dimerization interface [polypeptide binding]; other site 358681015495 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 358681015496 DNA binding site [nucleotide binding] 358681015497 ATP-dependent transcriptional regulator [Transcription]; Region: MalT; COG2909 358681015498 AAA ATPase domain; Region: AAA_16; pfam13191 358681015499 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 358681015500 DNA binding residues [nucleotide binding] 358681015501 dimerization interface [polypeptide binding]; other site 358681015502 RDD family; Region: RDD; pfam06271 358681015503 Dipeptidyl peptidase IV (DPP IV) N-terminal region; Region: DPPIV_N; pfam00930 358681015504 Dipeptidyl aminopeptidases/acylaminoacyl-peptidases [Amino acid transport and metabolism]; Region: DAP2; COG1506 358681015505 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 358681015506 Cache domain; Region: Cache_1; pfam02743 358681015507 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 358681015508 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 358681015509 metal binding site [ion binding]; metal-binding site 358681015510 active site 358681015511 I-site; other site 358681015512 Prolyl 4-hydroxylase alpha subunit homologues; Region: P4Hc; smart00702 358681015513 Branched-chain amino acid transport protein; Region: Branch_AA_trans; pfam05525 358681015514 Predicted membrane protein (DUF2306); Region: DUF2306; pfam10067 358681015515 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 358681015516 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 358681015517 dimer interface [polypeptide binding]; other site 358681015518 phosphorylation site [posttranslational modification] 358681015519 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 358681015520 ATP binding site [chemical binding]; other site 358681015521 Mg2+ binding site [ion binding]; other site 358681015522 G-X-G motif; other site 358681015523 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 358681015524 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 358681015525 active site 358681015526 phosphorylation site [posttranslational modification] 358681015527 intermolecular recognition site; other site 358681015528 dimerization interface [polypeptide binding]; other site 358681015529 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 358681015530 DNA binding site [nucleotide binding] 358681015531 Predicted ferric reductase [Inorganic ion transport and metabolism]; Region: COG4097 358681015532 Membrane-associated lipoprotein involved in thiamine biosynthesis [Coenzyme metabolism]; Region: ApbE; COG1477 358681015533 ApbE family; Region: ApbE; pfam02424 358681015534 Protein of unknown function (DUF3231); Region: DUF3231; pfam11553 358681015535 Protein of unknown function (DUF3231); Region: DUF3231; pfam11553 358681015536 Small protein B (SmpB) is a component of the trans-translation system in prokaryotes for releasing stalled ribosome from damaged messenger RNAs; Region: SmpB; cd09294 358681015537 SmpB-tmRNA interface; other site 358681015538 ribonuclease R; Region: RNase_R; TIGR02063 358681015539 Ribonuclease B OB domain; Region: OB_RNB; pfam08206 358681015540 Ribonuclease B OB domain; Region: OB_RNB; pfam08206 358681015541 RNB domain; Region: RNB; pfam00773 358681015542 S1_RNase_R: RNase R C-terminal S1 domain. RNase R is a processive 3' to 5' exoribonuclease, which is a homolog of RNase II. RNase R degrades RNA with secondary structure having a 3' overhang of at least 7 nucleotides. RNase R and PNPase...; Region: S1_RNase_R; cd04471 358681015543 RNA binding site [nucleotide binding]; other site 358681015544 Preprotein translocase SecG subunit; Region: SecG; cl09123 358681015545 YqzM-like protein; Region: YqzM; pfam14141 358681015546 Cytochrome c; Region: Cytochrom_C; pfam00034 358681015547 ABC-type uncharacterized transport system, ATPase component [General function prediction only]; Region: COG4619 358681015548 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 358681015549 Walker A/P-loop; other site 358681015550 ATP binding site [chemical binding]; other site 358681015551 Q-loop/lid; other site 358681015552 ABC transporter signature motif; other site 358681015553 Walker B; other site 358681015554 D-loop; other site 358681015555 H-loop/switch region; other site 358681015556 ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG0390 358681015557 RNA polymerase sigma factor SigX; Provisional; Region: PRK09639 358681015558 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 358681015559 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 358681015560 DNA binding residues [nucleotide binding] 358681015561 Domain of unknown function (DUF4309); Region: DUF4309; pfam14172 358681015562 Domain of unknown function (DUF4309); Region: DUF4309; pfam14172 358681015563 ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614 358681015564 Fe3+-siderophore binding domain FhuD. These proteins have been shown to function as initial receptors in ABC transport of Fe3+-siderophores in many eubacterial species. They belong to the TroA-like superfamily of helical backbone metal receptor proteins...; Region: FhuD; cd01146 358681015565 siderophore binding site; other site 358681015566 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 358681015567 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 358681015568 ABC-ATPase subunit interface; other site 358681015569 dimer interface [polypeptide binding]; other site 358681015570 putative PBP binding regions; other site 358681015571 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 358681015572 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 358681015573 ABC-ATPase subunit interface; other site 358681015574 dimer interface [polypeptide binding]; other site 358681015575 putative PBP binding regions; other site 358681015576 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 358681015577 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 358681015578 Walker A/P-loop; other site 358681015579 ATP binding site [chemical binding]; other site 358681015580 Q-loop/lid; other site 358681015581 ABC transporter signature motif; other site 358681015582 Walker B; other site 358681015583 D-loop; other site 358681015584 H-loop/switch region; other site 358681015585 enolase; Provisional; Region: eno; PRK00077 358681015586 Enolase: Enolases are homodimeric enzymes that catalyse the reversible dehydration of 2-phospho-D-glycerate to phosphoenolpyruvate as part of the glycolytic and gluconeogenesis pathways. The reaction is facilitated by the presence of metal ions; Region: enolase; cd03313 358681015587 dimer interface [polypeptide binding]; other site 358681015588 metal binding site [ion binding]; metal-binding site 358681015589 substrate binding pocket [chemical binding]; other site 358681015590 Phosphoglyceromutase [Carbohydrate transport and metabolism]; Region: GpmI; COG0696 358681015591 phosphoglyceromutase; Provisional; Region: PRK05434 358681015592 Triosephosphate isomerase (TIM) is a glycolytic enzyme that catalyzes the interconversion of dihydroxyacetone phosphate and D-glyceraldehyde-3-phosphate. The reaction is very efficient and requires neither cofactors nor metal ions. TIM, usually...; Region: TIM; cd00311 358681015593 triosephosphate isomerase; Provisional; Region: PRK14565 358681015594 substrate binding site [chemical binding]; other site 358681015595 dimer interface [polypeptide binding]; other site 358681015596 catalytic triad [active] 358681015597 Phosphoglycerate kinase; Region: PGK; pfam00162 358681015598 Phosphoglycerate kinase (PGK) is a monomeric enzyme which catalyzes the transfer of the high-energy phosphate group of 1,3-bisphosphoglycerate to ADP, forming ATP and 3-phosphoglycerate. This reaction represents the first of the two substrate-level...; Region: Phosphoglycerate_kinase; cd00318 358681015599 substrate binding site [chemical binding]; other site 358681015600 hinge regions; other site 358681015601 ADP binding site [chemical binding]; other site 358681015602 catalytic site [active] 358681015603 Glyceraldehyde-3-phosphate dehydrogenase/erythrose-4-phosphate dehydrogenase [Carbohydrate transport and metabolism]; Region: GapA; COG0057 358681015604 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; smart00846 358681015605 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800 358681015606 Na+/H+ antiporter NhaC; Region: antiport_nhaC; TIGR00931 358681015607 60Kd inner membrane protein; Region: 60KD_IMP; cl00489 358681015608 Transcriptional regulator, contains sigma factor-related N-terminal domain [Transcription]; Region: DeoR; COG2390 358681015609 Putative sugar-binding domain; Region: Sugar-bind; pfam04198 358681015610 Glutaredoxin-like domain (DUF836); Region: DUF836; pfam05768 358681015611 RNA polymerase factor sigma-54; Reviewed; Region: PRK05932 358681015612 Sigma-54 factor, Activator interacting domain (AID); Region: Sigma54_AID; pfam00309 358681015613 Sigma-54 factor, core binding domain; Region: Sigma54_CBD; pfam04963 358681015614 Sigma-54, DNA binding domain; Region: Sigma54_DBD; pfam04552 358681015615 ABC-type enterobactin transport system, permease component [Inorganic ion transport and metabolism]; Region: FepG; COG4779 358681015616 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 358681015617 ABC-ATPase subunit interface; other site 358681015618 dimer interface [polypeptide binding]; other site 358681015619 putative PBP binding regions; other site 358681015620 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 358681015621 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 358681015622 ABC-ATPase subunit interface; other site 358681015623 dimer interface [polypeptide binding]; other site 358681015624 putative PBP binding regions; other site 358681015625 Fe3+-siderophore binding domain FhuD. These proteins have been shown to function as initial receptors in ABC transport of Fe3+-siderophores in many eubacterial species. They belong to the TroA-like superfamily of helical backbone metal receptor proteins...; Region: FhuD; cd01146 358681015626 Periplasmic binding protein; Region: Peripla_BP_2; pfam01497 358681015627 siderophore binding site; other site 358681015628 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 358681015629 FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202 358681015630 putative active site [active] 358681015631 heme pocket [chemical binding]; other site 358681015632 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 358681015633 putative active site [active] 358681015634 heme pocket [chemical binding]; other site 358681015635 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 358681015636 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 358681015637 putative active site [active] 358681015638 heme pocket [chemical binding]; other site 358681015639 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 358681015640 dimer interface [polypeptide binding]; other site 358681015641 phosphorylation site [posttranslational modification] 358681015642 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 358681015643 ATP binding site [chemical binding]; other site 358681015644 Mg2+ binding site [ion binding]; other site 358681015645 G-X-G motif; other site 358681015646 Protein of unknown function (DUF4023); Region: DUF4023; pfam13215 358681015647 ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683 358681015648 Type I periplasmic ligand-binding domain of ABC (Atpase Binding Cassette)-type active transport systems that are involved in the transport of all three branched chain aliphatic amino acids (leucine, isoleucine and valine); Region: PBP1_ABC_LIVBP_like; cd06342 358681015649 dimerization interface [polypeptide binding]; other site 358681015650 ligand binding site [chemical binding]; other site 358681015651 Copper amine oxidase N-terminal domain; Region: Cu_amine_oxidN1; pfam07833 358681015652 Clp protease; Region: CLP_protease; pfam00574 358681015653 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017 358681015654 oligomer interface [polypeptide binding]; other site 358681015655 active site residues [active] 358681015656 Small acid-soluble spore protein H family; Region: SspH; cl06949 358681015657 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367 358681015658 dimerization domain swap beta strand [polypeptide binding]; other site 358681015659 regulatory protein interface [polypeptide binding]; other site 358681015660 active site 358681015661 regulatory phosphorylation site [posttranslational modification]; other site 358681015662 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1481 358681015663 Sporulation Regulator WhiA N terminal; Region: WhiA_N; pfam10298 358681015664 conserved hypothetical protein, cofD-related; Region: CofD_related; TIGR01826 358681015665 family of mostly uncharacterized proteins similar to B.subtilis YvcK; Region: YvcK_like; cd07187 358681015666 phosphate binding site [ion binding]; other site 358681015667 putative substrate binding pocket [chemical binding]; other site 358681015668 dimer interface [polypeptide binding]; other site 358681015669 glmZ(sRNA)-inactivating NTPase; Provisional; Region: PRK05416 358681015670 Dephospho-CoA kinase [Coenzyme metabolism]; Region: CoaE; COG0237 358681015671 thioredoxin-disulfide reductase; Region: TRX_reduct; TIGR01292 358681015672 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 358681015673 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 358681015674 TPR repeat; Region: TPR_11; pfam13414 358681015675 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 358681015676 TPR motif; other site 358681015677 binding surface 358681015678 TPR repeat; Region: TPR_11; pfam13414 358681015679 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 358681015680 TPR motif; other site 358681015681 binding surface 358681015682 bifunctional phosphoribosyl-AMP cyclohydrolase/phosphoribosyl-ATP pyrophosphatase protein; Reviewed; Region: PRK02759 358681015683 phosphoribosyl-AMP cyclohydrolase; Reviewed; Region: hisI; PRK00051 358681015684 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in Escherichia coli phosphoribosyl-ATP pyrophosphohydrolase (HisIE or PRATP-PH) and its homologs; Region: NTP-PPase_HisIE_like; cd11534 358681015685 metal binding site [ion binding]; metal-binding site 358681015686 The cyclase subunit of imidazoleglycerol phosphate synthase (HisF). Imidazole glycerol phosphate synthase (IGPS) catalyzes the fifth step of histidine biosynthesis, the formation of the imidazole ring. IGPS converts N1-(5'-phosphoribulosyl)...; Region: HisF; cd04731 358681015687 Histidine biosynthesis protein; Region: His_biosynth; pfam00977 358681015688 substrate binding site [chemical binding]; other site 358681015689 glutamase interaction surface [polypeptide binding]; other site 358681015690 HisA. Phosphoribosylformimino-5-aminoimidazole carboxamide ribonucleotide (ProFAR) isomerase catalyzes the fourth step in histidine biosynthesis, an isomerisation of the aminoaldose moiety of ProFAR to the aminoketose of PRFAR (N-(5'-phospho-D-1...; Region: HisA; cd04732 358681015691 phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase; Region: TIGR00007 358681015692 catalytic residues [active] 358681015693 imidazole glycerol phosphate synthase subunit HisH; Provisional; Region: hisH; PRK13141 358681015694 Type 1 glutamine amidotransferase (GATase1) domain found in imidazole glycerol phosphate synthase (IGPS); Region: GATase1_IGP_Synthase; cd01748 358681015695 putative active site [active] 358681015696 oxyanion strand; other site 358681015697 catalytic triad [active] 358681015698 Imidazoleglycerol-phosphate dehydratase; Region: IGPD; cd07914 358681015699 putative active site pocket [active] 358681015700 4-fold oligomerization interface [polypeptide binding]; other site 358681015701 metal binding residues [ion binding]; metal-binding site 358681015702 3-fold/trimer interface [polypeptide binding]; other site 358681015703 Histidinol dehydrogenase, HisD, E.C 1.1.1.23. Histidinol dehydrogenase catalyzes the last two steps in the L-histidine biosynthesis pathway, which is conserved in bacteria, archaea, fungi, and plants. These last two steps are (i) the NAD-dependent...; Region: Histidinol_dh; cd06572 358681015704 histidinol dehydrogenase; Region: hisD; TIGR00069 358681015705 NAD binding site [chemical binding]; other site 358681015706 dimerization interface [polypeptide binding]; other site 358681015707 product binding site; other site 358681015708 substrate binding site [chemical binding]; other site 358681015709 zinc binding site [ion binding]; other site 358681015710 catalytic residues [active] 358681015711 ATP phosphoribosyltransferase catalytic subunit; Reviewed; Region: hisG; PRK01686 358681015712 ATP phosphoribosyltransferase [Amino acid transport and metabolism]; Region: HisG; COG0040 358681015713 ATP phosphoribosyltransferase regulatory subunit; Provisional; Region: hisZ; PRK12292 358681015714 Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for...; Region: HisRS-like_core; cd00773 358681015715 dimer interface [polypeptide binding]; other site 358681015716 motif 1; other site 358681015717 active site 358681015718 motif 2; other site 358681015719 motif 3; other site 358681015720 Acetyltransferase (isoleucine patch superfamily) [General function prediction only]; Region: WbbJ; COG0110 358681015721 Maltose O-acyltransferase (MAT)-like: This family is composed of maltose O-acetyltransferase, galactoside O-acetyltransferase (GAT), xenobiotic acyltransferase (XAT) and similar proteins. MAT and GAT catalyze the CoA-dependent acetylation of the...; Region: LbH_MAT_like; cd04647 358681015722 trimer interface [polypeptide binding]; other site 358681015723 active site 358681015724 substrate binding site [chemical binding]; other site 358681015725 CoA binding site [chemical binding]; other site 358681015726 HPr Serine kinase N terminus; Region: Hpr_kinase_N; pfam02603 358681015727 Hpr(Ser) kinase/phosphatase; Region: hpr-ser; TIGR00679 358681015728 HprK/P, the bifunctional histidine-containing protein kinase/phosphatase, controls the phosphorylation state of the phosphocarrier protein HPr and regulates the utilization of carbon sources by gram-positive bacteria. It catalyzes both the ATP-dependent...; Region: HprK_C; cd01918 358681015729 Hpr binding site; other site 358681015730 active site 358681015731 homohexamer subunit interaction site [polypeptide binding]; other site 358681015732 Predicted membrane protein [Function unknown]; Region: COG1950 358681015733 Predicted HD superfamily hydrolase [General function prediction only]; Region: COG1418 358681015734 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 358681015735 Zn2+ binding site [ion binding]; other site 358681015736 Mg2+ binding site [ion binding]; other site 358681015737 excinuclease ABC subunit A; Reviewed; Region: uvrA; PRK00349 358681015738 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 358681015739 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 358681015740 ATP-binding cassette domain II of the excision repair protein UvrA; Region: ABC_UvrA_II; cd03271 358681015741 excinuclease ABC subunit B; Provisional; Region: PRK05298 358681015742 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 358681015743 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 358681015744 nucleotide binding region [chemical binding]; other site 358681015745 ATP-binding site [chemical binding]; other site 358681015746 Ultra-violet resistance protein B; Region: UvrB; pfam12344 358681015747 Flagellar hook capping protein - N-terminal region; Region: FlgD; pfam03963 358681015748 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 358681015749 C-terminal processing peptidase family S41; Region: Peptidase_S41; cl02526 358681015750 C-terminal peptidase (prc); Region: prc; TIGR00225 358681015751 PDZ domain of C-terminal processing-, tail-specific-, and tricorn proteases, which function in posttranslational protein processing, maturation, and disassembly or degradation, in Bacteria, Archaea, and plant chloroplasts. May be responsible for...; Region: PDZ_CTP_protease; cd00988 358681015752 protein binding site [polypeptide binding]; other site 358681015753 C-terminal processing peptidase; serine protease family S41; Region: Peptidase_S41_CPP; cd07560 358681015754 Catalytic dyad [active] 358681015755 Putative peptidoglycan-binding domain-containing protein [Cell envelope biogenesis, outer membrane]; Region: COG3409 358681015756 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 358681015757 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3883 358681015758 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 358681015759 Peptidase family M23; Region: Peptidase_M23; pfam01551 358681015760 Cell division protein [Cell division and chromosome partitioning]; Region: FtsX; COG2177 358681015761 cell division ABC transporter subunit FtsX; Provisional; Region: ftsX; PRK11026 358681015762 Predicted ATPase involved in cell division [Cell division and chromosome partitioning]; Region: FtsE; COG2884 358681015763 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 358681015764 Walker A/P-loop; other site 358681015765 ATP binding site [chemical binding]; other site 358681015766 Q-loop/lid; other site 358681015767 ABC transporter signature motif; other site 358681015768 Walker B; other site 358681015769 D-loop; other site 358681015770 H-loop/switch region; other site 358681015771 Uncharacterized oxidoreductases, Fe-dependent alcohol dehydrogenase family [Energy production and conversion]; Region: COG1979 358681015772 Butanol dehydrogenase catalyzes the conversion of butyraldehyde to butanol with the cofactor NAD(P)H being oxidized in the process; Region: BDH; cd08187 358681015773 dimer interface [polypeptide binding]; other site 358681015774 active site 358681015775 metal binding site [ion binding]; metal-binding site 358681015776 Spore germination protein; Region: Spore_permease; cl17796 358681015777 Predicted acetamidase/formamidase [Energy production and conversion]; Region: COG2421 358681015778 argininosuccinate lyase; Provisional; Region: PRK00855 358681015779 Argininosuccinate lyase (argininosuccinase, ASAL); Region: Argininosuccinate_lyase; cd01359 358681015780 active sites [active] 358681015781 tetramer interface [polypeptide binding]; other site 358681015782 argininosuccinate synthase; Provisional; Region: PRK13820 358681015783 Argininosuccinate synthase. The Argininosuccinate synthase is a urea cycle enzyme that catalyzes the penultimate step in arginine biosynthesis: the ATP-dependent ligation of citrulline to aspartate to form argininosuccinate, AMP and pyrophosphate . In...; Region: Argininosuccinate_Synthase; cd01999 358681015784 ANP binding site [chemical binding]; other site 358681015785 Substrate Binding Site II [chemical binding]; other site 358681015786 Substrate Binding Site I [chemical binding]; other site 358681015787 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 358681015788 catalytic core [active] 358681015789 c-di-GMP phosphodiesterase class II (HD-GYP domain) [Signal transduction mechanisms]; Region: COG2206 358681015790 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 358681015791 Zn2+ binding site [ion binding]; other site 358681015792 Mg2+ binding site [ion binding]; other site 358681015793 ornithine carbamoyltransferase; Provisional; Region: PRK00779 358681015794 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 358681015795 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 358681015796 carbamoyl phosphate synthase large subunit; Reviewed; Region: carB; PRK05294 358681015797 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 358681015798 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786 358681015799 Carbamoyl-phosphate synthetase large chain, oligomerisation domain; Region: CPSase_L_D3; pfam02787 358681015800 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 358681015801 ATP-grasp domain; Region: ATP-grasp_4; cl17255 358681015802 MGS-like domain. This domain composes the whole protein of methylglyoxal synthetase, which catalyzes the enolization of dihydroxyacetone phosphate (DHAP) to produce methylglyoxal. The family also includes the C-terminal domain in carbamoyl phosphate...; Region: MGS-like; cl00245 358681015803 substrate binding site [chemical binding]; other site 358681015804 Carbamoyl-phosphate synthase small chain, CPSase domain; Region: CPSase_sm_chain; pfam00988 358681015805 carbamoyl phosphate synthase small subunit; Reviewed; Region: PRK12838 358681015806 Small chain of the glutamine-dependent form of carbamoyl phosphate synthase, CPSase II; Region: GATase1_CPSase; cd01744 358681015807 catalytic site [active] 358681015808 subunit interface [polypeptide binding]; other site 358681015809 acetylornithine aminotransferase; Provisional; Region: PRK02627 358681015810 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 358681015811 inhibitor-cofactor binding pocket; inhibition site 358681015812 pyridoxal 5'-phosphate binding site [chemical binding]; other site 358681015813 catalytic residue [active] 358681015814 AAK_NAGK-like: N-Acetyl-L-glutamate kinase (NAGK)-like . Included in this CD are the Escherichia coli and Pseudomonas aeruginosa type NAGKs which catalyze the phosphorylation of N-acetyl-L-glutamate (NAG) by ATP in the second step of arginine...; Region: AAK_NAGK-like; cd04238 358681015815 nucleotide binding site [chemical binding]; other site 358681015816 N-acetyl-L-glutamate binding site [chemical binding]; other site 358681015817 N-acetyl-gamma-glutamyl-phosphate reductase; Validated; Region: argC; PRK00436 358681015818 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 358681015819 Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010 358681015820 Cytochrome C oxidase, cbb3-type, subunit III; Region: Cytochrome_CBB3; pfam13442 358681015821 YCII-related domain; Region: YCII; cl00999 358681015822 PAS domain S-box; Region: sensory_box; TIGR00229 358681015823 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 358681015824 putative active site [active] 358681015825 heme pocket [chemical binding]; other site 358681015826 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 358681015827 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 358681015828 putative active site [active] 358681015829 heme pocket [chemical binding]; other site 358681015830 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 358681015831 dimer interface [polypeptide binding]; other site 358681015832 phosphorylation site [posttranslational modification] 358681015833 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 358681015834 ATP binding site [chemical binding]; other site 358681015835 Mg2+ binding site [ion binding]; other site 358681015836 G-X-G motif; other site 358681015837 peptide chain release factor 2; Validated; Region: prfB; PRK00578 358681015838 This domain is found in peptide chain release factors; Region: PCRF; smart00937 358681015839 RF-1 domain; Region: RF-1; pfam00472 358681015840 preprotein translocase subunit SecA; Reviewed; Region: PRK12904 358681015841 SecA preprotein cross-linking domain; Region: SecA_PP_bind; smart00958 358681015842 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cl17351 358681015843 nucleotide binding region [chemical binding]; other site 358681015844 ATP-binding site [chemical binding]; other site 358681015845 RaiA ("ribosome-associated inhibitor A", also known as Protein Y (PY), YfiA, and SpotY, is a stress-response protein that binds the ribosomal subunit interface and arrests translation by interfering with aminoacyl-tRNA binding to the ribosomal...; Region: RaiA; cd00552 358681015846 30S subunit binding site; other site 358681015847 c-di-GMP phosphodiesterase class II (HD-GYP domain) [Signal transduction mechanisms]; Region: COG2206 358681015848 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 358681015849 Zn2+ binding site [ion binding]; other site 358681015850 Mg2+ binding site [ion binding]; other site 358681015851 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 358681015852 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 358681015853 dimer interface [polypeptide binding]; other site 358681015854 conserved gate region; other site 358681015855 putative PBP binding loops; other site 358681015856 ABC-ATPase subunit interface; other site 358681015857 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 358681015858 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 358681015859 substrate binding pocket [chemical binding]; other site 358681015860 membrane-bound complex binding site; other site 358681015861 hinge residues; other site 358681015862 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 358681015863 ligand binding site [chemical binding]; other site 358681015864 flagellar motor protein MotP; Reviewed; Region: PRK06926 358681015865 MotA/TolQ/ExbB proton channel family; Region: MotA_ExbB; cl00568 358681015866 Flagellar protein FliT; Region: FliT; pfam05400 358681015867 Flagellar protein FliS; Region: FliS; cl00654 358681015868 flagellar capping protein; Validated; Region: fliD; PRK07737 358681015869 Flagellar hook-associated protein 2 C-terminus; Region: FliD_N; pfam02465 358681015870 Flagellar hook-associated protein 2 C-terminus; Region: FliD_C; pfam07195 358681015871 FlaG protein; Region: FlaG; cl00591 358681015872 Methyltransferase domain; Region: Methyltransf_31; pfam13847 358681015873 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 358681015874 S-adenosylmethionine binding site [chemical binding]; other site 358681015875 Sulfatase; Region: Sulfatase; cl17466 358681015876 CMP-NeuAc_Synthase activates N-acetylneuraminic acid by adding CMP moiety; Region: CMP-NeuAc_Synthase; cd02513 358681015877 ligand binding site; other site 358681015878 tetramer interface; other site 358681015879 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domain associated with the NTP (Nucleotidyl transferase) domain downstream. CBS is a small domain originally identified in cystathionine beta-synthase and subsequently...; Region: CBS_pair_NTP_transferase_assoc; cd04607 358681015880 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis/translation initiation factor 2B, gamma/epsilon subunits (eIF-2Bgamma/eIF-2Bepsilon) [Cell envelope biogenesis, outer membrane / Translation, ribosomal structure...; Region: GCD1; COG1208 358681015881 NTP_trnasferase_like_2 is a member of the nucleotidyl transferase family; Region: NTP_transferase_like_2; cd06426 358681015882 Substrate binding site; other site 358681015883 metal-binding site 358681015884 Putative Acyltransferase (AT), Left-handed parallel beta-Helix (LbH) domain; This group is composed of mostly uncharacterized proteins containing an N-terminal helical subdomain followed by a LbH domain. The alignment contains 6 turns, each containing...; Region: LbH_AT_putative; cd03360 358681015885 sugar O-acyltransferase, sialic acid O-acetyltransferase NeuD family; Region: NeuD_NnaD; TIGR03570 358681015886 putative trimer interface [polypeptide binding]; other site 358681015887 putative CoA binding site [chemical binding]; other site 358681015888 N-acetylneuraminate synthase; Region: NeuB_NnaB; TIGR03569 358681015889 NeuB family; Region: NeuB; pfam03102 358681015890 C-terminal SAF domain of sialic acid synthetase; Region: SAF_NeuB_like; cd11615 358681015891 NeuB binding interface [polypeptide binding]; other site 358681015892 putative substrate binding site [chemical binding]; other site 358681015893 Uncharacterized proteins, LmbE homologs [Function unknown]; Region: COG2120 358681015894 Bacterial members of the UDP-N-Acetylglucosamine (GlcNAc) 2-Epimerase family are known to catalyze the reversible interconversion of UDP-GlcNAc and UDP-N-acetylmannosamine (UDP-ManNAc). The enzyme serves to produce an activated form of ManNAc residues; Region: GT1_UDP-GlcNAc_2-Epimerase; cd03786 358681015895 UDP-N-acetyl-D-glucosamine 2-epimerase, UDP-hydrolysing; Region: NeuC_NnaA; TIGR03568 358681015896 active site 358681015897 homodimer interface [polypeptide binding]; other site 358681015898 Methyltransferase domain; Region: Methyltransf_23; pfam13489 358681015899 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 358681015900 S-adenosylmethionine binding site [chemical binding]; other site 358681015901 WbqC-like protein family; Region: WbqC; pfam08889 358681015902 aminotransferase, LLPSF_NHT_00031 family; Region: NHT_00031; TIGR04181 358681015903 3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616 358681015904 inhibitor-cofactor binding pocket; inhibition site 358681015905 pyridoxal 5'-phosphate binding site [chemical binding]; other site 358681015906 catalytic residue [active] 358681015907 Arna decarboxylase_like, extended (e) SDRs; Region: Arna_like_SDR_e; cd05257 358681015908 NAD dependent epimerase/dehydratase, LLPSF_EDH_00030 family; Region: EDH_00030; TIGR04180 358681015909 NAD binding site [chemical binding]; other site 358681015910 substrate binding site [chemical binding]; other site 358681015911 active site 358681015912 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2604 358681015913 flagellin; Provisional; Region: PRK12804 358681015914 Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669 358681015915 Bacterial flagellin C-terminal helical region; Region: Flagellin_C; pfam00700 358681015916 carbon storage regulator; Provisional; Region: PRK01712 358681015917 FliW protein; Region: FliW; cl00740 358681015918 flagellar hook-associated protein FlgL; Validated; Region: flgL; PRK07701 358681015919 Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669 358681015920 Bacterial flagellin C-terminal helical region; Region: Flagellin_C; pfam00700 358681015921 flagellar hook-associated protein FlgK; Validated; Region: flgK; PRK07739 358681015922 Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460 358681015923 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 358681015924 FlgN protein; Region: FlgN; pfam05130 358681015925 flagellar biosynthesis anti-sigma factor FlgM; Region: FlgM_jcvi; TIGR03824 358681015926 flagellar operon protein TIGR03826; Region: YvyF 358681015927 comF family protein; Region: comF; TIGR00201 358681015928 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 358681015929 active site 358681015930 Superfamily II DNA/RNA helicase required for DNA uptake (late competence protein) [DNA replication, recombination, and repair]; Region: comFA; COG4098 358681015931 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 358681015932 nucleotide binding region [chemical binding]; other site 358681015933 ATP-binding site [chemical binding]; other site 358681015934 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 358681015935 salt bridge; other site 358681015936 non-specific DNA binding site [nucleotide binding]; other site 358681015937 sequence-specific DNA binding site [nucleotide binding]; other site 358681015938 Adenylation domain of proteins similar to ATP-dependent polynucleotide ligases; Region: Adenylation_DNA_ligase_like; cl12015 358681015939 The Oligonucleotide/oligosaccharide binding (OB)-fold domain is a DNA-binding module that is part of the catalytic core unit of ATP dependent DNA ligases; Region: OBF_DNA_ligase_family; cl08424 358681015940 DNA binding site [nucleotide binding] 358681015941 Muramidase (flagellum-specific) [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FlgJ; COG1705 358681015942 Haemolysin XhlA; Region: XhlA; pfam10779 358681015943 Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726 358681015944 Putative catalytic NodB homology domain of uncharacterized prokaryotic polysaccharide deacetylases which consist of a 6-stranded beta/alpha barrel; Region: CE4_DAC_u1_6s; cd10970 358681015945 putative active site [active] 358681015946 putative metal binding site [ion binding]; other site 358681015947 Uncharacterized protein conserved in bacteria (DUF2313); Region: DUF2313; cl01542 358681015948 Baseplate J-like protein; Region: Baseplate_J; pfam04865 358681015949 Protein of unknown function (DUF2634); Region: DUF2634; pfam10934 358681015950 Protein of unknown function (DUF2577); Region: DUF2577; pfam10844 358681015951 tape measure domain; Region: tape_meas_nterm; TIGR02675 358681015952 Phage XkdN-like protein; Region: XkdN; pfam08890 358681015953 Protein of unknown function (DUF2001); Region: DUF2001; pfam09393 358681015954 Phage tail sheath protein; Region: Phage_sheath_1; cl01389 358681015955 Bacteriophage protein of unknown function (DUF646); Region: DUF646; cl12124 358681015956 Phage head-tail joining protein; Region: Phage_H_T_join; cl11461 358681015957 Phage head-tail joining protein; Region: Phage_H_T_join; pfam05521 358681015958 phage major capsid protein, HK97 family; Region: major_cap_HK97; TIGR01554 358681015959 Phage capsid family; Region: Phage_capsid; pfam05065 358681015960 Phage head maturation protease [General function prediction only]; Region: COG3740 358681015961 Phage-related protein [Function unknown]; Region: COG4695; cl01923 358681015962 Phage portal protein; Region: Phage_portal; pfam04860 358681015963 Phage terminase-like protein, large subunit [General function prediction only]; Region: COG4626 358681015964 Phage terminase, small subunit; Region: Terminase_4; cl01525 358681015965 Restriction endonuclease [Defense mechanisms]; Region: McrA; COG1403 358681015966 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 358681015967 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 358681015968 active site 358681015969 Phage regulatory protein Rha (Phage_pRha); Region: Phage_pRha; cl10713 358681015970 replicative DNA helicase; Region: DnaB; TIGR00665 358681015971 DnaB-like helicase N terminal domain; Region: DnaB; pfam00772 358681015972 DnaB helicase C terminal domain. The hexameric helicase DnaB unwinds the DNA duplex at the chromosome replication fork. Although the mechanism by which DnaB both couples ATP hydrolysis to translocation along DNA and denatures the duplex is unknown, a...; Region: DnaB_C; cd00984 358681015973 Walker A motif; other site 358681015974 ATP binding site [chemical binding]; other site 358681015975 Walker B motif; other site 358681015976 DNA binding loops [nucleotide binding] 358681015977 hypothetical protein; Validated; Region: PRK08116 358681015978 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 358681015979 Walker A motif; other site 358681015980 ATP binding site [chemical binding]; other site 358681015981 Walker B motif; other site 358681015982 Helix-turn-helix domain; Region: HTH_36; pfam13730 358681015983 Conserved phage C-terminus (Phg_2220_C); Region: Phg_2220_C; pfam09524 358681015984 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl17200 358681015985 non-specific DNA binding site [nucleotide binding]; other site 358681015986 salt bridge; other site 358681015987 sequence-specific DNA binding site [nucleotide binding]; other site 358681015988 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 358681015989 salt bridge; other site 358681015990 non-specific DNA binding site [nucleotide binding]; other site 358681015991 sequence-specific DNA binding site [nucleotide binding]; other site 358681015992 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 358681015993 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 358681015994 non-specific DNA binding site [nucleotide binding]; other site 358681015995 salt bridge; other site 358681015996 sequence-specific DNA binding site [nucleotide binding]; other site 358681015997 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961 358681015998 Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and...; Region: SR_ResInv; cd03768 358681015999 catalytic residues [active] 358681016000 catalytic nucleophile [active] 358681016001 Presynaptic Site I dimer interface [polypeptide binding]; other site 358681016002 Synaptic Antiparallel dimer interface [polypeptide binding]; other site 358681016003 Synaptic Flat tetramer interface [polypeptide binding]; other site 358681016004 Synaptic Site I dimer interface [polypeptide binding]; other site 358681016005 DNA binding site [nucleotide binding] 358681016006 Recombinase; Region: Recombinase; pfam07508 358681016007 Recombinase zinc beta ribbon domain; Region: Zn_ribbon_recom; pfam13408 358681016008 Superfamily II DNA/RNA helicase required for DNA uptake (late competence protein) [DNA replication, recombination, and repair]; Region: comFA; COG4098 358681016009 active site 358681016010 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 358681016011 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 358681016012 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 358681016013 active site 358681016014 phosphorylation site [posttranslational modification] 358681016015 intermolecular recognition site; other site 358681016016 dimerization interface [polypeptide binding]; other site 358681016017 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 358681016018 DNA binding residues [nucleotide binding] 358681016019 dimerization interface [polypeptide binding]; other site 358681016020 Sensor protein DegS; Region: DegS; pfam05384 358681016021 Histidine kinase; Region: HisKA_3; pfam07730 358681016022 Histidine kinase-like ATPase domain; Region: HATPase_c_2; pfam13581 358681016023 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 358681016024 ATP binding site [chemical binding]; other site 358681016025 Mg2+ binding site [ion binding]; other site 358681016026 G-X-G motif; other site 358681016027 Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726 358681016028 Putative catalytic NodB homology domain of PgaB, IcaB, and similar proteins which consist of a deformed (beta/alpha)8 barrel fold with 5- or 6-strands; Region: CE4_NodB_like_5s_6s; cd10918 358681016029 putative active site [active] 358681016030 putative metal binding site [ion binding]; other site 358681016031 S-adenosylmethionine synthetase; Validated; Region: PRK05250 358681016032 S-adenosylmethionine synthetase, N-terminal domain; Region: S-AdoMet_synt_N; pfam00438 358681016033 S-adenosylmethionine synthetase, central domain; Region: S-AdoMet_synt_M; pfam02772 358681016034 S-adenosylmethionine synthetase, C-terminal domain; Region: S-AdoMet_synt_C; pfam02773 358681016035 Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cl10459 358681016036 active site 358681016037 catalytic residues [active] 358681016038 S-layer homology domain; Region: SLH; pfam00395 358681016039 S-layer homology domain; Region: SLH; pfam00395 358681016040 S-layer homology domain; Region: SLH; pfam00395 358681016041 site-specific tyrosine recombinase XerC; Reviewed; Region: xerC; PRK00236 358681016042 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 358681016043 active site 358681016044 DNA binding site [nucleotide binding] 358681016045 Int/Topo IB signature motif; other site 358681016046 S-layer homology domain; Region: SLH; pfam00395 358681016047 S-layer homology domain; Region: SLH; pfam00395 358681016048 Outer membrane efflux protein; Region: OEP; pfam02321 358681016049 Outer membrane protein [Cell envelope biogenesis, outer membrane / Intracellular trafficking and secretion]; Region: TolC; COG1538 358681016050 uncharacterized protein, YigZ family; Region: IMPACT_YIGZ; TIGR00257 358681016051 Uncharacterized protein family UPF0029; Region: UPF0029; pfam01205 358681016052 Domain of unknown function (DUF1949); Region: DUF1949; pfam09186 358681016053 S-layer homology domain; Region: SLH; pfam00395 358681016054 S-layer homology domain; Region: SLH; pfam00395 358681016055 S-layer homology domain; Region: SLH; pfam00395 358681016056 UDP-N-acetylmuramyl pentapeptide phosphotransferase/UDP-N- acetylglucosamine-1-phosphate transferase [Cell envelope biogenesis, outer membrane]; Region: Rfe; COG0472 358681016057 This subfamily contains Escherichia coli WecA, Bacillus subtilis TagO and related proteins. WecA is an UDP-N-acetylglucosamine (GlcNAc):undecaprenyl-phosphate (Und-P) GlcNAc-1-phosphate transferase that catalyzes the formation of a phosphodiester bond...; Region: GT_WecA_like; cd06853 358681016058 Mg++ binding site [ion binding]; other site 358681016059 putative catalytic motif [active] 358681016060 substrate binding site [chemical binding]; other site 358681016061 Teichoic acid biosynthesis proteins [Cell envelope biogenesis, outer membrane]; Region: WecG; COG1922 358681016062 The glycosyltransferase WecG/TagA superfamily contains Escherichia coli WecG, Bacillus subtilis TagA and related proteins. E. coli WecG is believed to be a UDP-N-acetyl-D-mannosaminuronic acid transferase, and is involved in enterobacterial common...; Region: Glyco_transf_WecG_TagA; cd06533 358681016063 FabZ is a 17kD beta-hydroxyacyl-acyl carrier protein (ACP) dehydratase that primarily catalyzes the dehydration of beta-hydroxyacyl-ACP to trans-2-acyl-ACP, the third step in the elongation phase of the bacterial/ plastid, type II, fatty-acid...; Region: FabZ; cd01288 358681016064 CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; cl00453 358681016065 DNA-directed RNA polymerase subunit beta; Region: EpuA; pfam11772 358681016066 Flagellar basal body rod protein [Cell motility and secretion]; Region: FlgG; COG4786 358681016067 Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460 358681016068 flagellar basal-body rod protein FlgF; Region: flgF; TIGR02490 358681016069 Flagellar basal body rod protein [Cell motility and secretion]; Region: FlgG; COG4786 358681016070 Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460 358681016071 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; cl15855 358681016072 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 358681016073 rod shape-determining protein Mbl; Provisional; Region: PRK13928 358681016074 MreB and similar proteins; Region: MreB_like; cd10225 358681016075 nucleotide binding site [chemical binding]; other site 358681016076 Mg binding site [ion binding]; other site 358681016077 putative protofilament interaction site [polypeptide binding]; other site 358681016078 RodZ interaction site [polypeptide binding]; other site 358681016079 Stage III sporulation protein D; Region: SpoIIID; pfam12116 358681016080 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 358681016081 Peptidase family M23; Region: Peptidase_M23; pfam01551 358681016082 stage II sporulation protein D; Region: spore_II_D; TIGR02870 358681016083 Stage II sporulation protein; Region: SpoIID; pfam08486 358681016084 UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Region: murA; TIGR01072 358681016085 UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555 358681016086 hinge; other site 358681016087 active site 358681016088 Protein of unknown function (DUF1779); Region: DUF1779; pfam08680 358681016089 Protein of unknown function (DUF1146); Region: DUF1146; cl11486 358681016090 NADH:ubiquinone oxidoreductase subunit N; Provisional; Region: PRK05777 358681016091 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 358681016092 NADH:ubiquinone oxidoreductase subunit M; Reviewed; Region: PRK05846 358681016093 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 358681016094 NADH:ubiquinone oxidoreductase subunit L; Reviewed; Region: PRK06590 358681016095 NADH-Ubiquinone oxidoreductase (complex I), chain 5 N-terminus; Region: Oxidored_q1_N; pfam00662 358681016096 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 358681016097 NADH:ubiquinone oxidoreductase subunit K; Validated; Region: PRK05715 358681016098 NADH:ubiquinone oxidoreductase subunit 6 (chain J) [Energy production and conversion]; Region: NuoJ; COG0839 358681016099 NADH dehydrogenase subunit J; Provisional; Region: PRK06433 358681016100 NADH-quinone oxidoreductase, chain I; Region: NuoI; TIGR01971 358681016101 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 358681016102 NADH:ubiquinone oxidoreductase subunit H; Provisional; Region: PRK06076 358681016103 Formate hydrogenlyase subunit 4 [Energy production and conversion]; Region: HyfC; COG0650 358681016104 NADH dehydrogenase subunit D; Provisional; Region: PRK12322 358681016105 NADH:ubiquinone oxidoreductase 49 kD subunit 7 [Energy production and conversion]; Region: NuoD; COG0649 358681016106 NADH dehydrogenase subunit C; Validated; Region: PRK07735 358681016107 NADH (or F420H2) dehydrogenase, subunit C; Region: NuoC_fam; TIGR01961 358681016108 NADH dehydrogenase subunit B; Validated; Region: PRK06411 358681016109 NADH dehydrogenase subunit A; Validated; Region: PRK07756 358681016110 F0F1 ATP synthase subunit epsilon; Validated; Region: atpC; PRK00571 358681016111 mitochondrial ATP synthase delta subunit; Region: F1-ATPase_delta; cd12152 358681016112 gamma subunit interface [polypeptide binding]; other site 358681016113 epsilon subunit interface [polypeptide binding]; other site 358681016114 LBP interface [polypeptide binding]; other site 358681016115 F0F1 ATP synthase subunit beta; Validated; Region: PRK09280 358681016116 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 358681016117 F1 ATP synthase beta subunit, nucleotide-binding domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a...; Region: F1-ATPase_beta; cd01133 358681016118 alpha subunit interaction interface [polypeptide binding]; other site 358681016119 Walker A motif; other site 358681016120 ATP binding site [chemical binding]; other site 358681016121 Walker B motif; other site 358681016122 inhibitor binding site; inhibition site 358681016123 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 358681016124 mitochondrial ATP synthase gamma subunit; Region: F1-ATPase_gamma; cd12151 358681016125 core domain interface [polypeptide binding]; other site 358681016126 delta subunit interface [polypeptide binding]; other site 358681016127 epsilon subunit interface [polypeptide binding]; other site 358681016128 F0F1 ATP synthase subunit alpha; Validated; Region: PRK09281 358681016129 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 358681016130 F1 ATP synthase alpha, central domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a proton gradient to...; Region: F1_ATPase_alpha; cd01132 358681016131 beta subunit interaction interface [polypeptide binding]; other site 358681016132 Walker A motif; other site 358681016133 ATP binding site [chemical binding]; other site 358681016134 Walker B motif; other site 358681016135 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 358681016136 F0F1 ATP synthase subunit delta; Validated; Region: PRK05758 358681016137 ATP synthase delta (OSCP) subunit; Region: OSCP; pfam00213 358681016138 F0F1-type ATP synthase, subunit b [Energy production and conversion]; Region: AtpF; COG0711 358681016139 F0F1 ATP synthase subunit B; Validated; Region: PRK05759 358681016140 F0F1 ATP synthase subunit C; Validated; Region: PRK06876 358681016141 F0F1-type ATP synthase, subunit a [Energy production and conversion]; Region: AtpB; COG0356 358681016142 F0F1 ATP synthase subunit A; Validated; Region: PRK05815 358681016143 Putative F0F1-ATPase subunit (ATPase_gene1); Region: ATPase_gene1; pfam09527 358681016144 putative acyltransferase; Provisional; Region: PRK05790 358681016145 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 358681016146 dimer interface [polypeptide binding]; other site 358681016147 active site 358681016148 biotin biosynthesis protein BioC; Region: BioC; TIGR02072 358681016149 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 358681016150 S-adenosylmethionine binding site [chemical binding]; other site 358681016151 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 358681016152 homoserine O-acetyltransferase; Provisional; Region: metX; cl17114 358681016153 TAP-like protein; Region: Abhydrolase_4; pfam08386 358681016154 pyridoxal phosphate-dependent acyltransferase, putative; Region: gly_Cac_T_rel; TIGR01825 358681016155 KBL_like; this family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to serine palmitoyltransferase (SPT), 5-aminolevulinate synthase (ALAS); Region: KBL_like; cd06454 358681016156 substrate-cofactor binding pocket; other site 358681016157 pyridoxal 5'-phosphate binding site [chemical binding]; other site 358681016158 catalytic residue [active] 358681016159 biotin synthase; Validated; Region: PRK06256 358681016160 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 358681016161 FeS/SAM binding site; other site 358681016162 Biotin and Thiamin Synthesis associated domain; Region: BATS; pfam06968 358681016163 dithiobiotin synthetase; Reviewed; Region: bioD; PRK00090 358681016164 AAA domain; Region: AAA_26; pfam13500 358681016165 adenosylmethionine--8-amino-7-oxononanoate transaminase; Provisional; Region: PRK06916 358681016166 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 358681016167 inhibitor-cofactor binding pocket; inhibition site 358681016168 pyridoxal 5'-phosphate binding site [chemical binding]; other site 358681016169 catalytic residue [active] 358681016170 Predicted periplasmic protein (DUF2233); Region: DUF2233; pfam09992 358681016171 Predicted periplasmic protein (DUF2233); Region: DUF2233; pfam09992 358681016172 Bacterial Ig-like domain (group 2); Region: Big_2; cl02708 358681016173 S-layer homology domain; Region: SLH; pfam00395 358681016174 S-layer homology domain; Region: SLH; pfam00395 358681016175 UDP-N-acetylglucosamine 2-epimerase [Cell envelope biogenesis, outer membrane]; Region: WecB; COG0381 358681016176 Bacterial members of the UDP-N-Acetylglucosamine (GlcNAc) 2-Epimerase family are known to catalyze the reversible interconversion of UDP-GlcNAc and UDP-N-acetylmannosamine (UDP-ManNAc). The enzyme serves to produce an activated form of ManNAc residues; Region: GT1_UDP-GlcNAc_2-Epimerase; cd03786 358681016177 active site 358681016178 homodimer interface [polypeptide binding]; other site 358681016179 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 358681016180 active site 358681016181 serine hydroxymethyltransferase; Reviewed; Region: glyA; PRK00011 358681016182 Serine-glycine hydroxymethyltransferase (SHMT). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). SHMT carries out interconversion of serine and glycine; it catalyzes the transfer of hydroxymethyl...; Region: SHMT; cd00378 358681016183 dimer interface [polypeptide binding]; other site 358681016184 active site 358681016185 glycine-pyridoxal phosphate binding site [chemical binding]; other site 358681016186 folate binding site [chemical binding]; other site 358681016187 hypothetical protein; Provisional; Region: PRK13690 358681016188 ribose-5-phosphate isomerase B; Provisional; Region: PRK05571 358681016189 Low molecular weight phosphatase family; Region: LMWPc; cd00115 358681016190 Low molecular weight phosphotyrosine protein phosphatase; Region: LMWPc; pfam01451 358681016191 active site 358681016192 putative sporulation protein YtaF; Region: spore_YtaF; TIGR02840 358681016193 Domain of unknown function DUF; Region: DUF204; pfam02659 358681016194 Domain of unknown function DUF; Region: DUF204; pfam02659 358681016195 Putative translation factor (SUA5) [Translation, ribosomal structure and biogenesis]; Region: SUA5; COG0009 358681016196 Putative GTP-binding controlling metal-binding; Region: SUA5; pfam03481 358681016197 Domain of unknown function (DUF4163); Region: DUF4163; pfam13739 358681016198 Protein of unknown function (DUF3298); Region: DUF3298; pfam11738 358681016199 Stage II sporulation protein R (spore_II_R); Region: Spore_II_R; pfam09551 358681016200 N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase; Provisional; Region: PRK09328 358681016201 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 358681016202 S-adenosylmethionine binding site [chemical binding]; other site 358681016203 peptide chain release factor 1; Validated; Region: prfA; PRK00591 358681016204 This domain is found in peptide chain release factors; Region: PCRF; smart00937 358681016205 RF-1 domain; Region: RF-1; pfam00472 358681016206 thymidine kinase; Provisional; Region: PRK04296 358681016207 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 358681016208 ATP binding site [chemical binding]; other site 358681016209 Walker B motif; other site 358681016210 Deoxyribodipyrimidine photolyase [DNA replication, recombination, and repair]; Region: PhrB; COG0415 358681016211 DNA photolyase; Region: DNA_photolyase; pfam00875 358681016212 50S ribosomal protein L31; Reviewed; Region: rpmE; PRK00019 358681016213 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 358681016214 Radical SAM superfamily; Region: Radical_SAM; pfam04055 358681016215 FeS/SAM binding site; other site 358681016216 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 358681016217 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 358681016218 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 358681016219 Peptidase family M23; Region: Peptidase_M23; pfam01551 358681016220 transcription termination factor Rho; Provisional; Region: rho; PRK09376 358681016221 Rho termination factor, N-terminal domain; Region: Rho_N; pfam07498 358681016222 Rho_CSD: Rho protein cold-shock domain (CSD). Rho protein is a transcription termination factor in most bacteria. In bacteria, there are two distinct mechanisms for mRNA transcription termination. In intrinsic termination, RNA polymerase and nascent mRNA...; Region: Rho_CSD; cd04459 358681016223 RNA binding site [nucleotide binding]; other site 358681016224 Transcription termination factor rho is a bacterial ATP-dependent RNA/DNA helicase. It is a homohexamer. Each monomer consists of an N-terminal domain of the OB fold, which is responsible for binding to cysteine rich nucleotides. This alignment is of the...; Region: rho_factor; cd01128 358681016225 multimer interface [polypeptide binding]; other site 358681016226 Walker A motif; other site 358681016227 ATP binding site [chemical binding]; other site 358681016228 Walker B motif; other site 358681016229 Bacterial fructose-1,6-bisphosphatase, glpX-encoded. A dimeric enzyme dependent on Mg(2+). glpX-encoded FPBase (FBPase class II) differs from other members of the inositol-phosphatase superfamily by permutation of secondary structure elements. The core...; Region: FBPase_glpX; cd01516 358681016230 Bacterial fructose-1,6-bisphosphatase, glpX-encoded; Region: FBPase_glpX; pfam03320 358681016231 putative active site [active] 358681016232 UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Region: murA; TIGR01072 358681016233 UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555 358681016234 hinge; other site 358681016235 active site 358681016236 Transaldolase-like fructose-6-phosphate aldolases (FSA) found in bacteria and archaea; Region: Transaldolase_FSA; cd00956 358681016237 active site 358681016238 intersubunit interactions; other site 358681016239 catalytic residue [active] 358681016240 Tagatose-1,6-bisphosphate (TBP) aldolase and related Type B Class II aldolases. TBP aldolase is a tetrameric class II aldolase that catalyzes the reversible condensation of dihydroxyacetone phosphate with glyceraldehyde 3-phsophate to produce tagatose 1; Region: TBP_aldolase_IIB; cd00947 358681016241 fructose-bisphosphate aldolase; Provisional; Region: PRK09197 358681016242 intersubunit interface [polypeptide binding]; other site 358681016243 active site 358681016244 zinc binding site [ion binding]; other site 358681016245 Na+ binding site [ion binding]; other site 358681016246 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 358681016247 Response regulator receiver domain; Region: Response_reg; pfam00072 358681016248 active site 358681016249 phosphorylation site [posttranslational modification] 358681016250 intermolecular recognition site; other site 358681016251 dimerization interface [polypeptide binding]; other site 358681016252 Protein of unknown function (DUF2837); Region: DUF2837; pfam10997 358681016253 CTP synthetase; Validated; Region: pyrG; PRK05380 358681016254 CTP synthetase (CTPs) is a two-domain protein, which consists of an N-terminal synthetase domain and C-terminal glutaminase domain. The enzymes hydrolyze the amide bond of glutamine to ammonia and glutamate at the glutaminase domains and transfer nascent...; Region: CTGs; cd03113 358681016255 Catalytic site [active] 358681016256 active site 358681016257 UTP binding site [chemical binding]; other site 358681016258 Type 1 glutamine amidotransferase (GATase1) domain found in Cytidine Triphosphate Synthetase; Region: GATase1_CTP_Synthase; cd01746 358681016259 active site 358681016260 putative oxyanion hole; other site 358681016261 catalytic triad [active] 358681016262 DNA-directed RNA polymerase subunit delta; Reviewed; Region: PRK02363 358681016263 methylmalonyl CoA mutase B12 binding domain. This domain binds to B12 (adenosylcobamide), which initiates the conversion of succinyl CoA and methylmalonyl CoA by forming an adenosyl radical, which then undergoes a rearrangement exchanging a hydrogen atom...; Region: MM_CoA_mut_B12_BD; cd02071 358681016264 B12 binding site [chemical binding]; other site 358681016265 cobalt ligand [ion binding]; other site 358681016266 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 358681016267 Coenzyme B12-dependent-methylmalonyl coenzyme A (CoA) mutase (MCM)-like family; contains proteins similar to MCM, and the large subunit of Streptomyces coenzyme B12-dependent isobutyryl-CoA mutase (ICM). MCM catalyzes the isomerization of...; Region: MM_CoA_mutase; cl00817 358681016268 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 358681016269 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 358681016270 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 358681016271 Short chain acyl-CoA dehydrogenases and eukaryotic short/branched chain acyl-CoA dehydrogenases; Region: SCAD_SBCAD; cd01158 358681016272 FAD binding site [chemical binding]; other site 358681016273 homotetramer interface [polypeptide binding]; other site 358681016274 substrate binding pocket [chemical binding]; other site 358681016275 catalytic base [active] 358681016276 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 358681016277 Short chain acyl-CoA dehydrogenases and eukaryotic short/branched chain acyl-CoA dehydrogenases; Region: SCAD_SBCAD; cd01158 358681016278 FAD binding site [chemical binding]; other site 358681016279 homotetramer interface [polypeptide binding]; other site 358681016280 substrate binding pocket [chemical binding]; other site 358681016281 catalytic base [active] 358681016282 3-hydroxybutyryl-CoA dehydrogenase; Validated; Region: PRK05808 358681016283 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 358681016284 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 358681016285 acetyl-CoA acetyltransferase; Provisional; Region: PRK08235 358681016286 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 358681016287 dimer interface [polypeptide binding]; other site 358681016288 active site 358681016289 RNA polymerase factor sigma C; Reviewed; Region: PRK09415 358681016290 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 358681016291 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 358681016292 DNA binding residues [nucleotide binding] 358681016293 Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247 358681016294 Cysteine-rich domain; Region: CCG; pfam02754 358681016295 Cysteine-rich domain; Region: CCG; pfam02754 358681016296 lysine-2,3-aminomutase; Region: lys_2_3_AblA; TIGR03820 358681016297 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 358681016298 FeS/SAM binding site; other site 358681016299 Lysine-2,3-aminomutase; Region: LAM_C; pfam12544 358681016300 PAS domain S-box; Region: sensory_box; TIGR00229 358681016301 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 358681016302 putative active site [active] 358681016303 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204 358681016304 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 358681016305 Walker A motif; other site 358681016306 ATP binding site [chemical binding]; other site 358681016307 Walker B motif; other site 358681016308 arginine finger; other site 358681016309 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 358681016310 Domain of unknown function (DUF1934); Region: DUF1934; pfam09148 358681016311 H+ Antiporter protein; Region: 2A0121; TIGR00900 358681016312 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 358681016313 putative substrate translocation pore; other site 358681016314 agmatinase; Region: agmatinase; TIGR01230 358681016315 Agmatinase and related proteins; Region: Agmatinase-like_2; cd11593 358681016316 putative active site [active] 358681016317 Mn binding site [ion binding]; other site 358681016318 spermidine synthase; Provisional; Region: PRK00811 358681016319 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 358681016320 Transglycosylase; Region: Transgly; pfam00912 358681016321 penicillin-binding protein, 1A family; Region: PBP_1a_fam; TIGR02074 358681016322 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 358681016323 YwhD family; Region: YwhD; pfam08741 358681016324 Bacterial pre-peptidase C-terminal domain; Region: PPC; pfam04151 358681016325 Lecithin:cholesterol acyltransferase; Region: LACT; pfam02450 358681016326 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 358681016327 catalytic residues [active] 358681016328 Uncharacterized conserved protein [Function unknown]; Region: COG3465 358681016329 HD superfamily phosphohydrolases [General function prediction only]; Region: COG1078 358681016330 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 358681016331 Zn2+ binding site [ion binding]; other site 358681016332 Mg2+ binding site [ion binding]; other site 358681016333 Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841 358681016334 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 358681016335 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 358681016336 HlyD family secretion protein; Region: HlyD_3; pfam13437 358681016337 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 358681016338 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 358681016339 Integral membrane protein CcmA involved in cell shape determination [Cell envelope biogenesis, outer membrane]; Region: CcmA; COG1664 358681016340 Protein of unknown function (DUF4004); Region: DUF4004; pfam13171 358681016341 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 358681016342 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 358681016343 active site 358681016344 Thermophilic metalloprotease (M29); Region: Peptidase_M29; pfam02073 358681016345 Leucyl aminopeptidase (aminopeptidase T) [Amino acid transport and metabolism]; Region: AmpS; COG2309 358681016346 Major Facilitator Superfamily; Region: MFS_1; pfam07690 358681016347 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 358681016348 putative substrate translocation pore; other site 358681016349 S-layer homology domain; Region: SLH; pfam00395 358681016350 S-layer homology domain; Region: SLH; pfam00395 358681016351 S-layer homology domain; Region: SLH; pfam00395 358681016352 Predicted N6-adenine-specific DNA methylase [DNA replication, recombination, and repair]; Region: COG0116 358681016353 THUMP domain associated with S-adenosylmethionine-dependent methyltransferases; Region: THUMP_AdoMetMT; cd11715 358681016354 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 358681016355 Formamidopyrimidine-DNA glycosylase [DNA replication, recombination, and repair]; Region: Nei; COG0266 358681016356 Uncharacterized bacterial subgroup of the N-terminal domain of Fpg (formamidopyrimidine-DNA glycosylase, MutM)_Nei (endonuclease VIII) base-excision repair DNA glycosylases; Region: BaFpgNei_N_1; cd08973 358681016357 putative DNA binding site [nucleotide binding]; other site 358681016358 catalytic residue [active] 358681016359 putative H2TH interface [polypeptide binding]; other site 358681016360 putative catalytic residues [active] 358681016361 Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831 358681016362 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 358681016363 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 358681016364 Coenzyme A binding pocket [chemical binding]; other site 358681016365 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 358681016366 Ferredoxin [Energy production and conversion]; Region: Fdx; COG0633 358681016367 catalytic loop [active] 358681016368 iron binding site [ion binding]; other site 358681016369 Thiamine pyrophosphokinase; Region: TPK; cd07995 358681016370 thiamine pyrophosphokinase; Region: thi_PPkinase; TIGR01378 358681016371 active site 358681016372 dimerization interface [polypeptide binding]; other site 358681016373 thiamine binding site [chemical binding]; other site 358681016374 Family 1 of Uracil-DNA glycosylase (UDG) enzymes; Region: UDG_F1; cd10027 358681016375 ligand binding site [chemical binding]; other site 358681016376 active site 358681016377 UGI interface [polypeptide binding]; other site 358681016378 catalytic site [active] 358681016379 Copper amine oxidase N-terminal domain; Region: Cu_amine_oxidN1; pfam07833 358681016380 Arylamine N-acetyltransferase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: NhoA; COG2162 358681016381 Uncharacterized enzyme involved in biosynthesis of extracellular polysaccharides [General function prediction only]; Region: COG2329 358681016382 psp operon transcriptional activator PspF; Region: phageshock_pspF; TIGR02974 358681016383 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 358681016384 Walker A motif; other site 358681016385 ATP binding site [chemical binding]; other site 358681016386 Walker B motif; other site 358681016387 arginine finger; other site 358681016388 Bacterial regulatory protein, Fis family; Region: HTH_8; cl17420 358681016389 methionine gamma-lyase; Provisional; Region: PRK06767 358681016390 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 358681016391 homodimer interface [polypeptide binding]; other site 358681016392 substrate-cofactor binding pocket; other site 358681016393 pyridoxal 5'-phosphate binding site [chemical binding]; other site 358681016394 catalytic residue [active] 358681016395 Choline dehydrogenase and related flavoproteins [Amino acid transport and metabolism]; Region: BetA; COG2303 358681016396 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 358681016397 Gluconate 2-dehydrogenase subunit 3; Region: Gluconate_2-dh3; pfam13618 358681016398 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 358681016399 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 358681016400 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 358681016401 Coenzyme A binding pocket [chemical binding]; other site 358681016402 Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531 358681016403 glutaminyl-tRNA synthetase; Provisional; Region: PRK05347 358681016404 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 358681016405 active site 358681016406 HIGH motif; other site 358681016407 nucleotide binding site [chemical binding]; other site 358681016408 catalytic core domain of glutaminyl-tRNA synthetase; Region: GlnRS_core; cd00807 358681016409 KMSKS motif; other site 358681016410 tRNA synthetases class I (E and Q), anti-codon binding domain; Region: tRNA-synt_1c_C; pfam03950 358681016411 SET domain; Region: SET; pfam00856 358681016412 Gamma-glutamyltransferase [Amino acid transport and metabolism]; Region: Ggt; COG0405 358681016413 Gamma-glutamyltranspeptidase; Region: G_glu_transpept; pfam01019 358681016414 Cache domain; Region: Cache_1; pfam02743 358681016415 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 358681016416 dimerization interface [polypeptide binding]; other site 358681016417 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 358681016418 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 358681016419 dimer interface [polypeptide binding]; other site 358681016420 putative CheW interface [polypeptide binding]; other site 358681016421 Catalytic domain of phosphoinositide-specific phospholipase C-like phosphodiesterases superfamily; Region: PI-PLCc_GDPD_SF; cl14615 358681016422 Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584 358681016423 active site 358681016424 catalytic site [active] 358681016425 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 358681016426 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 358681016427 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 358681016428 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 358681016429 dimer interface [polypeptide binding]; other site 358681016430 conserved gate region; other site 358681016431 putative PBP binding loops; other site 358681016432 ABC-ATPase subunit interface; other site 358681016433 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 358681016434 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 358681016435 dimer interface [polypeptide binding]; other site 358681016436 conserved gate region; other site 358681016437 putative PBP binding loops; other site 358681016438 ABC-ATPase subunit interface; other site 358681016439 ABC-type sugar transport systems, ATPase components [Carbohydrate transport and metabolism]; Region: MalK; COG3839 358681016440 The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301 358681016441 Walker A/P-loop; other site 358681016442 ATP binding site [chemical binding]; other site 358681016443 Q-loop/lid; other site 358681016444 ABC transporter signature motif; other site 358681016445 Walker B; other site 358681016446 D-loop; other site 358681016447 H-loop/switch region; other site 358681016448 TOBE domain; Region: TOBE_2; pfam08402 358681016449 pyrophosphatase PpaX; Provisional; Region: PRK13288 358681016450 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 358681016451 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 358681016452 motif II; other site 358681016453 Glycerol-3-phosphate responsive antiterminator; Region: G3P_antiterm; cl00852 358681016454 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 358681016455 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 358681016456 putative substrate translocation pore; other site 358681016457 probable oxidoreductase, LLM family; Region: LLM_2I7G; TIGR03858 358681016458 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases [Energy production and conversion]; Region: COG2141 358681016459 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 358681016460 putative DNA binding site [nucleotide binding]; other site 358681016461 dimerization interface [polypeptide binding]; other site 358681016462 putative Zn2+ binding site [ion binding]; other site 358681016463 ASC-1 homology domain, subfamily similar to Escherichia coli Yqfb. The ASCH domain, a small beta-barrel domain found in all three kingdoms of life, resembles the RNA-binding PUA domain and may also interact with RNA. ASCH has been proposed to function as...; Region: ASCH_yqfb_like; cd06552 358681016464 Phosphorylase superfamily; Region: PNP_UDP_1; cl00303 358681016465 Sulfite oxidase and related enzymes [General function prediction only]; Region: COG2041 358681016466 bacterial and archael members of the sulfite oxidase (SO) family of molybdopterin binding domains. This molybdopterin cofactor (Moco) binding domain is found in a variety of oxidoreductases, main members of this family are nitrate reductase (NR) and...; Region: arch_bact_SO_family_Moco; cd02109 358681016467 Moco binding site; other site 358681016468 metal coordination site [ion binding]; other site 358681016469 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 358681016470 Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette; Region: TM_PBP1_transp_TpRbsC_like; cd06580 358681016471 TM-ABC transporter signature motif; other site 358681016472 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 358681016473 Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette; Region: TM_PBP1_transp_TpRbsC_like; cd06580 358681016474 TM-ABC transporter signature motif; other site 358681016475 ABC-type uncharacterized transport systems, ATPase components [General function prediction only]; Region: COG3845 358681016476 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 358681016477 Walker A/P-loop; other site 358681016478 ATP binding site [chemical binding]; other site 358681016479 Q-loop/lid; other site 358681016480 ABC transporter signature motif; other site 358681016481 Walker B; other site 358681016482 D-loop; other site 358681016483 H-loop/switch region; other site 358681016484 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 358681016485 Uncharacterized ABC-type transport system, periplasmic component/surface lipoprotein [General function prediction only]; Region: Med; COG1744 358681016486 Periplasmic binding component of a family of basic membrane lipoproteins from Borrelia and various putative lipoproteins from other bacteria; Region: PBP1_BmpA_like; cd06304 358681016487 ligand binding site [chemical binding]; other site 358681016488 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 358681016489 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 358681016490 dimer interface [polypeptide binding]; other site 358681016491 putative CheW interface [polypeptide binding]; other site 358681016492 Domain of unknown function (DUF4163); Region: DUF4163; pfam13739 358681016493 Protein of unknown function (DUF3298); Region: DUF3298; pfam11738 358681016494 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 358681016495 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 358681016496 dimerization interface [polypeptide binding]; other site 358681016497 putative Zn2+ binding site [ion binding]; other site 358681016498 putative DNA binding site [nucleotide binding]; other site 358681016499 Uncharacterized FAD-dependent dehydrogenases [General function prediction only]; Region: COG2509 358681016500 hydroxyglutarate oxidase; Provisional; Region: PRK11728 358681016501 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes Similar to D-Serine Dehydratase and D-Threonine Aldolase, Unknown Group 2; Region: PLPDE_III_DSD_D-TA_like_2; cd06813 358681016502 Predicted amino acid aldolase or racemase [Amino acid transport and metabolism]; Region: COG3616 358681016503 dimer interface [polypeptide binding]; other site 358681016504 active site 358681016505 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 358681016506 substrate binding site [chemical binding]; other site 358681016507 catalytic residue [active] 358681016508 FAD-linked oxidoreductase; Region: bact_FAD_ox; TIGR01679 358681016509 FAD binding domain; Region: FAD_binding_4; pfam01565 358681016510 D-arabinono-1,4-lactone oxidase; Region: ALO; pfam04030 358681016511 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 358681016512 non-specific DNA binding site [nucleotide binding]; other site 358681016513 salt bridge; other site 358681016514 sequence-specific DNA binding site [nucleotide binding]; other site 358681016515 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 358681016516 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 358681016517 Ankyrin repeats (many copies); Region: Ank_4; pfam13637 358681016518 Restriction endonuclease; Region: Mrr_cat; pfam04471 358681016519 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 358681016520 N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860 358681016521 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 358681016522 active site 358681016523 metal binding site [ion binding]; metal-binding site 358681016524 hypothetical protein; Provisional; Region: PRK14082 358681016525 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 358681016526 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 358681016527 DNA binding residues [nucleotide binding] 358681016528 S-methylmethionine transporter; Provisional; Region: PRK11387 358681016529 N-Dimethylarginine dimethylaminohydrolase [Amino acid transport and metabolism]; Region: COG1834 358681016530 Amidinotransferase; Region: Amidinotransf; cl12043 358681016531 helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346 358681016532 Transcriptional regulator [Transcription]; Region: IclR; COG1414 358681016533 Bacterial transcriptional regulator; Region: IclR; pfam01614 358681016534 M20 Peptidase Arginine utilization protein, RocB; Region: M20_ArgE_RocB; cd05654 358681016535 putative metal binding site [ion binding]; other site 358681016536 putative dimer interface [polypeptide binding]; other site 358681016537 Predicted redox protein, regulator of disulfide bond formation [Posttranslational modification, protein turnover, chaperones]; Region: COG1765 358681016538 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 358681016539 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 358681016540 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 358681016541 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 358681016542 Periplasmic binding protein; Region: Peripla_BP_2; pfam01497 358681016543 intersubunit interface [polypeptide binding]; other site 358681016544 ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614 358681016545 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 358681016546 intersubunit interface [polypeptide binding]; other site 358681016547 cardiolipin synthase; Region: bac_cardiolipin; TIGR04265 358681016548 Phospholipase_D-nuclease N-terminal; Region: PLDc_N; pfam13396 358681016549 Catalytic domain, repeat 1, of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_1; cd09110 358681016550 putative active site [active] 358681016551 catalytic site [active] 358681016552 catalytic domain repeat 2 of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_2; cd09112 358681016553 putative active site [active] 358681016554 catalytic site [active] 358681016555 Leucyl aminopeptidase (aminopeptidase T) [Amino acid transport and metabolism]; Region: AmpS; COG2309 358681016556 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 358681016557 Domain of unknown function (DUF4179); Region: DUF4179; pfam13786 358681016558 DNA-directed RNA polymerase specialized sigma subunit, sigma24 homolog [Transcription]; Region: RpoE; COG1595 358681016559 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 358681016560 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 358681016561 DNA binding residues [nucleotide binding] 358681016562 NTF2-like N-terminal transpeptidase domain; Region: MecA_N; pfam05223 358681016563 Spo0E like sporulation regulatory protein; Region: SpoOE-like; pfam09388 358681016564 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 358681016565 non-specific DNA binding site [nucleotide binding]; other site 358681016566 salt bridge; other site 358681016567 sequence-specific DNA binding site [nucleotide binding]; other site 358681016568 Spo0E like sporulation regulatory protein; Region: SpoOE-like; pfam09388 358681016569 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 358681016570 non-specific DNA binding site [nucleotide binding]; other site 358681016571 salt bridge; other site 358681016572 sequence-specific DNA binding site [nucleotide binding]; other site 358681016573 malate dehydrogenase; Reviewed; Region: PRK06223 358681016574 L-lactate dehydrogenase-like malate dehydrogenase proteins; Region: LDH-like_MDH; cd01339 358681016575 NAD(P) binding site [chemical binding]; other site 358681016576 dimer interface [polypeptide binding]; other site 358681016577 tetramer (dimer of dimers) interface [polypeptide binding]; other site 358681016578 substrate binding site [chemical binding]; other site 358681016579 Ethanolamine ammonia-lyase light chain (EutC); Region: EutC; pfam05985 358681016580 ethanolamine ammonia lyase large subunit; Provisional; Region: PRK15067 358681016581 Ethanolamine ammonia lyase large subunit (EutB); Region: EutB; pfam06751 358681016582 reactivating factor for ethanolamine ammonia lyase; Provisional; Region: eutA; PRK10719 358681016583 Response regulator with putative antiterminator output domain [Signal transduction mechanisms]; Region: AmiR; COG3707 358681016584 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 358681016585 active site 358681016586 phosphorylation site [posttranslational modification] 358681016587 intermolecular recognition site; other site 358681016588 dimerization interface [polypeptide binding]; other site 358681016589 ANTAR domain; Region: ANTAR; pfam03861 358681016590 Signal transduction histidine kinase; Region: H_kinase_N; pfam12282 358681016591 PAS domain; Region: PAS_9; pfam13426 358681016592 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920 358681016593 Histidine kinase; Region: HisKA_2; pfam07568 358681016594 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 358681016595 ATP binding site [chemical binding]; other site 358681016596 Mg2+ binding site [ion binding]; other site 358681016597 G-X-G motif; other site 358681016598 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cd00882 358681016599 G1 box; other site 358681016600 GTP/Mg2+ binding site [chemical binding]; other site 358681016601 G2 box; other site 358681016602 Switch I region; other site 358681016603 G3 box; other site 358681016604 Switch II region; other site 358681016605 G4 box; other site 358681016606 G5 box; other site 358681016607 1,2-propanediol utilization protein U (PduU)/ethanolamine utilization protein S (EutS), Bacterial Micro-Compartment (BMC) domain; Region: BMC_PduU-EutS; cd07046 358681016608 putative hexamer interface [polypeptide binding]; other site 358681016609 putative hexagonal pore; other site 358681016610 Ethanolamine utilisation protein and carboxysome structural protein domain family; Region: EutN_CcmL; cd01614 358681016611 Hexamer/Pentamer interface [polypeptide binding]; other site 358681016612 central pore; other site 358681016613 ethanolamine utilization protein; Region: eut_hyp; TIGR02536 358681016614 Propanediol utilization protein [Secondary metabolites biosynthesis, transport, and catabolism]; Region: PduL; COG4869 358681016615 Propanediol utilisation protein PduL; Region: PduL; pfam06130 358681016616 Propanediol utilisation protein PduL; Region: PduL; pfam06130 358681016617 Carbon dioxide concentrating mechanism/carboxysome shell protein [Secondary metabolites biosynthesis, transport, and catabolism / Energy production and conversion]; Region: CcmK; COG4577 358681016618 1,2-propanediol utilization protein A (PduA), Bacterial Micro-Compartment (BMC) domain; Region: BMC_PduA; cd07059 358681016619 Hexamer interface [polypeptide binding]; other site 358681016620 Putative hexagonal pore residue; other site 358681016621 Coenzyme A acylating aldehyde dehydrogenase (ACDH), ALDH family 20-like; Region: ALDH_F20_ACDH; cd07122 358681016622 putative catalytic cysteine [active] 358681016623 Carbon dioxide concentrating mechanism K (CcmK)-like proteins, Bacterial Micro-Compartment (BMC) domain; Region: BMC_CcmK_like; cd07045 358681016624 Hexamer interface [polypeptide binding]; other site 358681016625 Hexagonal pore residue; other site 358681016626 ethanolamine utilization protein EutL; Provisional; Region: PRK15405 358681016627 ethanolamine utilization protein S (EutS), Bacterial Micro-Compartment (BMC) domain repeat 1; Region: BMC_EutL_repeat1; cd07049 358681016628 putative hexamer interface [polypeptide binding]; other site 358681016629 putative hexagonal pore; other site 358681016630 ethanolamine utilization protein S (EutS), Bacterial Micro-Compartment (BMC) domain repeat 2; Region: BMC_EutL_repeat2; cd07050 358681016631 putative hexamer interface [polypeptide binding]; other site 358681016632 putative hexagonal pore; other site 358681016633 translation initiation factor IF-2; Validated; Region: infB; PRK05306 358681016634 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 358681016635 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 358681016636 active site 358681016637 phosphorylation site [posttranslational modification] 358681016638 intermolecular recognition site; other site 358681016639 dimerization interface [polypeptide binding]; other site 358681016640 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 358681016641 DNA binding site [nucleotide binding] 358681016642 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 358681016643 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 358681016644 dimerization interface [polypeptide binding]; other site 358681016645 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 358681016646 dimer interface [polypeptide binding]; other site 358681016647 phosphorylation site [posttranslational modification] 358681016648 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 358681016649 ATP binding site [chemical binding]; other site 358681016650 G-X-G motif; other site 358681016651 LysR transcriptional regulator; Provisional; Region: rbcR; CHL00180 358681016652 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 358681016653 C-terminal substrate binding domain of LysR-type transcriptional regulator CysL, which activates the transcription of the cysJI operon encoding sulfite reductase, contains the type 2 periplasmic binding fold; Region: PBP2_CysL_like; cd08420 358681016654 putative dimerization interface [polypeptide binding]; other site 358681016655 Predicted membrane protein [Function unknown]; Region: COG2855 358681016656 Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119 358681016657 Sulfatase; Region: Sulfatase; pfam00884 358681016658 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367 358681016659 dimerization domain swap beta strand [polypeptide binding]; other site 358681016660 regulatory protein interface [polypeptide binding]; other site 358681016661 active site 358681016662 regulatory phosphorylation site [posttranslational modification]; other site 358681016663 Phosphoenolpyruvate-protein kinase (PTS system EI component in bacteria) [Carbohydrate transport and metabolism]; Region: PtsA; COG1080 358681016664 PEP-utilising enzyme, N-terminal; Region: PEP-utilisers_N; pfam05524 358681016665 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 358681016666 PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896 358681016667 mannitol-1-phosphate 5-dehydrogenase; Provisional; Region: PRK02318 358681016668 Mannitol dehydrogenase Rossmann domain; Region: Mannitol_dh; pfam01232 358681016669 Mannitol dehydrogenase C-terminal domain; Region: Mannitol_dh_C; pfam08125 358681016670 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 358681016671 active site 358681016672 phosphorylation site [posttranslational modification] 358681016673 Transcriptional antiterminator [Transcription]; Region: BglG; COG3711 358681016674 HTH domain; Region: HTH_11; pfam08279 358681016675 PRD domain; Region: PRD; pfam00874 358681016676 PRD domain; Region: PRD; pfam00874 358681016677 PTS_IIB_bgl_like: the PTS (phosphotransferase system) IIB domain of a family of sensory systems composed of a membrane-bound sugar-sensor (similar to BglF) and a transcription antiterminator (similar to BglG) which regulate expression of genes involved...; Region: PTS_IIB_bgl_like; cd05568 358681016678 active site 358681016679 P-loop; other site 358681016680 phosphorylation site [posttranslational modification] 358681016681 Phosphoenolpyruvate-dependent sugar phosphotransferase system, EIIA 2; Region: PTS_EIIA_2; pfam00359 358681016682 active site 358681016683 phosphorylation site [posttranslational modification] 358681016684 Phosphotransferase system, mannitol-specific IIBC component [Carbohydrate transport and metabolism]; Region: MtlA; COG2213 358681016685 PTS system, mannitol-specific IIC component; Region: mtlA; TIGR00851 358681016686 PTS_IIB_mannitol: subunit IIB of enzyme II (EII) of the mannitol-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII is a mannitol-specific permease with two cytoplasmic domains (IIA and IIB) and a transmembrane...; Region: PTS_IIB_mannitol; cd05567 358681016687 active site 358681016688 P-loop; other site 358681016689 phosphorylation site [posttranslational modification] 358681016690 helicase 45; Provisional; Region: PTZ00424 358681016691 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 358681016692 ATP binding site [chemical binding]; other site 358681016693 Mg++ binding site [ion binding]; other site 358681016694 motif III; other site 358681016695 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 358681016696 nucleotide binding region [chemical binding]; other site 358681016697 ATP-binding site [chemical binding]; other site 358681016698 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 358681016699 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 358681016700 substrate binding pocket [chemical binding]; other site 358681016701 membrane-bound complex binding site; other site 358681016702 hinge residues; other site 358681016703 Cache domain; Region: Cache_1; pfam02743 358681016704 Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840 358681016705 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 358681016706 dimerization interface [polypeptide binding]; other site 358681016707 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 358681016708 dimer interface [polypeptide binding]; other site 358681016709 putative CheW interface [polypeptide binding]; other site 358681016710 formate--tetrahydrofolate ligase; Provisional; Region: PRK13505 358681016711 Formyltetrahydrofolate synthetase (FTHFS) catalyzes the ATP-dependent activation of formate ion via its addition to the N10 position of tetrahydrofolate. FTHFS is a highly expressed key enzyme in both the Wood-Ljungdahl pathway of autotrophic CO2...; Region: FTHFS; cd00477 358681016712 Potassium binding sites [ion binding]; other site 358681016713 Cesium cation binding sites [ion binding]; other site 358681016714 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 358681016715 FAD binding domain; Region: FAD_binding_4; pfam01565 358681016716 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK07231 358681016717 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 358681016718 NAD(P) binding site [chemical binding]; other site 358681016719 active site 358681016720 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 358681016721 Uncharacterized ALDH (y4uC) with similarity to Tortula ruralis aldehyde dehydrogenase ALDH21A1; Region: ALDH_y4uC; cd07149 358681016722 NAD(P) binding site [chemical binding]; other site 358681016723 catalytic residues [active] 358681016724 Isocitrate/isopropylmalate dehydrogenase [Amino acid transport and metabolism]; Region: LeuB; COG0473 358681016725 tartrate dehydrogenase; Provisional; Region: PRK08194 358681016726 Transcriptional activator of acetoin/glycerol metabolism [Secondary metabolites biosynthesis, transport, and catabolism / Transcription]; Region: AcoR; COG3284 358681016727 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 358681016728 Walker A motif; other site 358681016729 ATP binding site [chemical binding]; other site 358681016730 Walker B motif; other site 358681016731 arginine finger; other site 358681016732 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 358681016733 Ralstonia eutrophus NAD+-dependent acetaldehyde dehydrogenase II-like; Region: ALDH_ACDHII-AcoD; cd07116 358681016734 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 358681016735 NAD(P) binding site [chemical binding]; other site 358681016736 catalytic residues [active] 358681016737 Protein of unknown function (DUF779); Region: DUF779; pfam05610 358681016738 helicase 45; Provisional; Region: PTZ00424 358681016739 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 358681016740 ATP binding site [chemical binding]; other site 358681016741 Mg++ binding site [ion binding]; other site 358681016742 motif III; other site 358681016743 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 358681016744 nucleotide binding region [chemical binding]; other site 358681016745 ATP-binding site [chemical binding]; other site 358681016746 Methyltransferase domain; Region: Methyltransf_23; pfam13489 358681016747 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 358681016748 S-adenosylmethionine binding site [chemical binding]; other site 358681016749 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 358681016750 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 358681016751 active site 358681016752 phosphorylation site [posttranslational modification] 358681016753 intermolecular recognition site; other site 358681016754 dimerization interface [polypeptide binding]; other site 358681016755 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 358681016756 DNA binding site [nucleotide binding] 358681016757 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 358681016758 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 358681016759 dimer interface [polypeptide binding]; other site 358681016760 phosphorylation site [posttranslational modification] 358681016761 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 358681016762 ATP binding site [chemical binding]; other site 358681016763 Mg2+ binding site [ion binding]; other site 358681016764 G-X-G motif; other site 358681016765 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367 358681016766 dimerization domain swap beta strand [polypeptide binding]; other site 358681016767 regulatory protein interface [polypeptide binding]; other site 358681016768 active site 358681016769 regulatory phosphorylation site [posttranslational modification]; other site 358681016770 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 358681016771 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 358681016772 active site 358681016773 motif I; other site 358681016774 motif II; other site 358681016775 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 358681016776 motif II; other site 358681016777 Alpha-galactosidases/6-phospho-beta-glucosidases, family 4 of glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: CelF; COG1486 358681016778 Glycoside Hydrolases Family 4; Phospho-beta-glucosidase; Region: GH4_P_beta_glucosidase; cd05296 358681016779 NAD binding site [chemical binding]; other site 358681016780 sugar binding site [chemical binding]; other site 358681016781 divalent metal binding site [ion binding]; other site 358681016782 tetramer (dimer of dimers) interface [polypeptide binding]; other site 358681016783 dimer interface [polypeptide binding]; other site 358681016784 PTS_IIA, PTS system, lactose/cellobiose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_lac; cd00215 358681016785 active site 358681016786 methionine cluster; other site 358681016787 phosphorylation site [posttranslational modification] 358681016788 metal binding site [ion binding]; metal-binding site 358681016789 Enterococcus faecalis EF3048 and similar proteins; Region: YdjC_EF3048_like; cd10803 358681016790 putative active site [active] 358681016791 YdjC motif; other site 358681016792 Mg binding site [ion binding]; other site 358681016793 putative homodimer interface [polypeptide binding]; other site 358681016794 cellobiose phosphotransferase system IIC component; Reviewed; Region: celD; PRK09592 358681016795 Phosphotransferase system cellobiose-specific component IIC [Carbohydrate transport and metabolism]; Region: CelB; cl17295 358681016796 PTS_IIB_chitobiose_lichenan: subunit IIB of enzyme II (EII) of the N,N-diacetylchitobiose-specific and lichenan-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In these systems, EII is either a lichenan- or an N; Region: PTS_IIB_chitobiose_lichenan; cd05564 358681016797 active site 358681016798 P-loop; other site 358681016799 phosphorylation site [posttranslational modification] 358681016800 Sugar-specific transcriptional regulator TrmB; Region: TrmB; cl17775 358681016801 Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain [Transcription / Signal transduction mechanisms]; Region: PspF; COG1221 358681016802 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 358681016803 Walker A motif; other site 358681016804 ATP binding site [chemical binding]; other site 358681016805 Walker B motif; other site 358681016806 arginine finger; other site 358681016807 Transcriptional antiterminator [Transcription]; Region: COG3933 358681016808 PRD domain; Region: PRD; pfam00874 358681016809 PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cl00025 358681016810 active pocket/dimerization site; other site 358681016811 active site 358681016812 phosphorylation site [posttranslational modification] 358681016813 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920 358681016814 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 358681016815 ATP binding site [chemical binding]; other site 358681016816 Mg2+ binding site [ion binding]; other site 358681016817 G-X-G motif; other site 358681016818 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 358681016819 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 358681016820 active site 358681016821 phosphorylation site [posttranslational modification] 358681016822 intermolecular recognition site; other site 358681016823 dimerization interface [polypeptide binding]; other site 358681016824 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 358681016825 DNA binding residues [nucleotide binding] 358681016826 bifunctional acyl-[acyl carrier protein] synthetase/2-acylglycerophosphoethanolamine acyltransferase; Validated; Region: PRK08043 358681016827 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 358681016828 putative acyl-acceptor binding pocket; other site 358681016829 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 358681016830 acyl-activating enzyme (AAE) consensus motif; other site 358681016831 AMP binding site [chemical binding]; other site 358681016832 active site 358681016833 CoA binding site [chemical binding]; other site 358681016834 lysophospholipid transporter LplT; Provisional; Region: PRK11195 358681016835 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 358681016836 putative substrate translocation pore; other site 358681016837 5'-nucleotidase/2',3'-cyclic phosphodiesterase and related esterases [Nucleotide transport and metabolism]; Region: UshA; COG0737 358681016838 Escherichia coli CpdB and related proteins, N-terminal metallophosphatase domain; Region: MPP_CpdB_N; cd07410 358681016839 active site 358681016840 metal binding site [ion binding]; metal-binding site 358681016841 5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872 358681016842 ATP-dependent DNA helicase RecQ; Region: recQ; TIGR01389 358681016843 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 358681016844 ATP binding site [chemical binding]; other site 358681016845 putative Mg++ binding site [ion binding]; other site 358681016846 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 358681016847 nucleotide binding region [chemical binding]; other site 358681016848 ATP-binding site [chemical binding]; other site 358681016849 This DNA-binding domain is found in the RecQ helicase among others and has a helix-turn-helix structure; Region: RQC; smart00956 358681016850 HRDC domain; Region: HRDC; pfam00570 358681016851 VanZ like family; Region: VanZ; cl01971 358681016852 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 358681016853 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 358681016854 dimer interface [polypeptide binding]; other site 358681016855 phosphorylation site [posttranslational modification] 358681016856 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 358681016857 ATP binding site [chemical binding]; other site 358681016858 Mg2+ binding site [ion binding]; other site 358681016859 G-X-G motif; other site 358681016860 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 358681016861 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 358681016862 active site 358681016863 phosphorylation site [posttranslational modification] 358681016864 intermolecular recognition site; other site 358681016865 dimerization interface [polypeptide binding]; other site 358681016866 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 358681016867 DNA binding site [nucleotide binding] 358681016868 short chain dehydrogenase; Provisional; Region: PRK12747 358681016869 tetrahydroxynaphthalene/trihydroxynaphthalene reductase-like, classical (c) SDRs; Region: THN_reductase-like_SDR_c; cd05362 358681016870 NADP binding site [chemical binding]; other site 358681016871 homodimer interface [polypeptide binding]; other site 358681016872 active site 358681016873 substrate binding site [chemical binding]; other site 358681016874 fumarate hydratase; Reviewed; Region: fumC; PRK00485 358681016875 Class II fumarases; Region: Fumarase_classII; cd01362 358681016876 active site 358681016877 tetramer interface [polypeptide binding]; other site 358681016878 putative Mg(2+) transport ATPase; Provisional; Region: PRK09977 358681016879 MgtC family; Region: MgtC; pfam02308 358681016880 multidrug efflux protein; Reviewed; Region: PRK01766 358681016881 Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Vibrio cholerae NorM; Region: MATE_NorM_like; cd13131 358681016882 cation binding site [ion binding]; other site 358681016883 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3397 358681016884 Chitin binding domain; Region: Chitin_bind_3; pfam03067 358681016885 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 358681016886 Interdomain contacts; other site 358681016887 Cytokine receptor motif; other site 358681016888 Uncharacterized protein contain chitin-binding domain type 3 [General function prediction only]; Region: COG3979 358681016889 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 358681016890 Interdomain contacts; other site 358681016891 Cytokine receptor motif; other site 358681016892 Chitin-binding domain of chitinase C; Region: ChiC_BD; cd12215 358681016893 aromatic chitin/cellulose binding site residues [chemical binding]; other site 358681016894 Chitin-binding domain of chitinase C; Region: ChiC_BD; cd12215 358681016895 aromatic chitin/cellulose binding site residues [chemical binding]; other site 358681016896 Adenine deaminase [Nucleotide transport and metabolism]; Region: AdeC; COG1001 358681016897 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 358681016898 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 358681016899 active site 358681016900 Adenine deaminase C-terminal domain; Region: Adenine_deam_C; pfam13382 358681016901 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 358681016902 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 358681016903 Walker A/P-loop; other site 358681016904 ATP binding site [chemical binding]; other site 358681016905 Q-loop/lid; other site 358681016906 ABC transporter signature motif; other site 358681016907 Walker B; other site 358681016908 D-loop; other site 358681016909 H-loop/switch region; other site 358681016910 TOBE domain; Region: TOBE_2; pfam08402 358681016911 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 358681016912 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 358681016913 dimer interface [polypeptide binding]; other site 358681016914 conserved gate region; other site 358681016915 putative PBP binding loops; other site 358681016916 ABC-ATPase subunit interface; other site 358681016917 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 358681016918 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 358681016919 dimer interface [polypeptide binding]; other site 358681016920 conserved gate region; other site 358681016921 putative PBP binding loops; other site 358681016922 ABC-ATPase subunit interface; other site 358681016923 nuc_hydro_IU_UC_XIUA: inosine-uridine preferring, xanthosine-inosine-uridine-adenosine-preferring and, uridine-cytidine preferring nucleoside hydrolases. Nucleoside hydrolases cleave the N-glycosidic bond in nucleosides generating ribose and the...; Region: nuc_hydro_IU_UC_XIUA; cd02651 358681016924 active site 358681016925 tetramer interface [polypeptide binding]; other site 358681016926 Spermidine/putrescine-binding periplasmic protein [Amino acid transport and metabolism]; Region: PotD; COG0687 358681016927 Bacterial extracellular solute-binding protein; Region: SBP_bac_6; pfam13343 358681016928 ABC-type metal ion transport system, periplasmic component/surface antigen [Inorganic ion transport and metabolism]; Region: NlpA; COG1464 358681016929 NLPA lipoprotein; Region: Lipoprotein_9; pfam03180 358681016930 DL-methionine transporter ATP-binding subunit; Provisional; Region: metN; PRK11153 358681016931 ATP-binding cassette domain of methionine transporter; Region: ABC_MetN_methionine_transporter; cd03258 358681016932 Walker A/P-loop; other site 358681016933 ATP binding site [chemical binding]; other site 358681016934 Q-loop/lid; other site 358681016935 ABC transporter signature motif; other site 358681016936 Walker B; other site 358681016937 D-loop; other site 358681016938 H-loop/switch region; other site 358681016939 NIL domain; Region: NIL; pfam09383 358681016940 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 358681016941 dimer interface [polypeptide binding]; other site 358681016942 conserved gate region; other site 358681016943 ABC-ATPase subunit interface; other site 358681016944 Protein of unknown function (DUF2653); Region: DUF2653; pfam10850 358681016945 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 358681016946 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 358681016947 Walker A/P-loop; other site 358681016948 ATP binding site [chemical binding]; other site 358681016949 Q-loop/lid; other site 358681016950 ABC transporter signature motif; other site 358681016951 Walker B; other site 358681016952 D-loop; other site 358681016953 H-loop/switch region; other site 358681016954 Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GAT_1; cl00020 358681016955 ABC-type enterochelin transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: CeuA; COG4607 358681016956 Siderophore binding protein FatB. These proteins have been shown to function as ABC-type initial receptors in the siderophore-mediated iron uptake in some eubacterial species. They belong to the TroA superfamily of periplasmic metal binding proteins...; Region: FatB; cd01140 358681016957 putative ligand binding residues [chemical binding]; other site 358681016958 ABC-type enterochelin transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CeuD; COG4604 358681016959 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 358681016960 Walker A/P-loop; other site 358681016961 ATP binding site [chemical binding]; other site 358681016962 Q-loop/lid; other site 358681016963 ABC transporter signature motif; other site 358681016964 Walker B; other site 358681016965 D-loop; other site 358681016966 H-loop/switch region; other site 358681016967 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 358681016968 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 358681016969 ABC-ATPase subunit interface; other site 358681016970 dimer interface [polypeptide binding]; other site 358681016971 putative PBP binding regions; other site 358681016972 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 358681016973 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 358681016974 ABC-ATPase subunit interface; other site 358681016975 dimer interface [polypeptide binding]; other site 358681016976 putative PBP binding regions; other site 358681016977 Domain of unknown function (DUF4097); Region: DUF4097; pfam13349 358681016978 Domain of unknown function (DUF4098); Region: DUF4098; pfam13345 358681016979 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 358681016980 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 358681016981 ligand binding site [chemical binding]; other site 358681016982 flexible hinge region; other site 358681016983 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 358681016984 putative switch regulator; other site 358681016985 non-specific DNA interactions [nucleotide binding]; other site 358681016986 DNA binding site [nucleotide binding] 358681016987 sequence specific DNA binding site [nucleotide binding]; other site 358681016988 putative cAMP binding site [chemical binding]; other site 358681016989 Carboxymuconolactone decarboxylase family; Region: CMD; cl00460 358681016990 Response regulator receiver domain; Region: Response_reg; pfam00072 358681016991 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 358681016992 active site 358681016993 phosphorylation site [posttranslational modification] 358681016994 intermolecular recognition site; other site 358681016995 dimerization interface [polypeptide binding]; other site 358681016996 Catalytic domain of Protein Kinases; Region: PKc; cd00180 358681016997 Serine/threonine protein kinase [General function prediction only / Signal transduction mechanisms / Transcription / DNA replication, recombination, and repair]; Region: SPS1; COG0515 358681016998 active site 358681016999 ATP binding site [chemical binding]; other site 358681017000 substrate binding site [chemical binding]; other site 358681017001 activation loop (A-loop); other site 358681017002 AAA ATPase domain; Region: AAA_16; pfam13191 358681017003 Predicted ATPase [General function prediction only]; Region: COG3899 358681017004 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 358681017005 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 358681017006 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 358681017007 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 358681017008 ATP binding site [chemical binding]; other site 358681017009 Mg2+ binding site [ion binding]; other site 358681017010 G-X-G motif; other site 358681017011 Cupin domain; Region: Cupin_2; pfam07883 358681017012 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 358681017013 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198 358681017014 metal ion-dependent adhesion site (MIDAS); other site 358681017015 Tubulin like; Region: Tubulin_2; pfam13809 358681017016 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198 358681017017 metal ion-dependent adhesion site (MIDAS); other site 358681017018 Bacterial SH3 domain; Region: SH3_3; pfam08239 358681017019 Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280 358681017020 Sortases are cysteine transpeptidases, found in gram-positive bacteria, that anchor surface proteins to peptidoglycans of the bacterial cell wall envelope. They do so by catalyzing a transpeptidation reaction in which the surface protein substrate is...; Region: Sortase; cl09098 358681017021 active site 358681017022 catalytic site [active] 358681017023 Predicted outer membrane protein [Cell envelope biogenesis, outer membrane]; Region: COG4932 358681017024 Collagen binding domain; Region: Collagen_bind; pfam05737 358681017025 Collagen binding domain; Region: Collagen_bind; pfam05737 358681017026 Collagen binding domain; Region: Collagen_bind; pfam05737 358681017027 Collagen binding domain; Region: Collagen_bind; pfam05737 358681017028 Cna protein B-type domain; Region: Cna_B; pfam05738 358681017029 Cna protein B-type domain; Region: Cna_B; pfam05738 358681017030 Cna protein B-type domain; Region: Cna_B; pfam05738 358681017031 Cna protein B-type domain; Region: Cna_B; pfam05738 358681017032 LPXTG-motif cell wall anchor domain; Region: LPXTG_anchor; TIGR01167 358681017033 PGAP1-like protein; Region: PGAP1; pfam07819 358681017034 Copper amine oxidase N-terminal domain; Region: Cu_amine_oxidN1; pfam07833 358681017035 Uncharacterized BCR, COG1649; Region: DUF187; pfam02638 358681017036 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 358681017037 intersubunit interface [polypeptide binding]; other site 358681017038 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 358681017039 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 358681017040 Sigma-70, region 4; Region: Sigma70_r4_2; pfam08281 358681017041 DNA binding residues [nucleotide binding] 358681017042 Nitric oxide synthase (NOS) produces nitric oxide (NO) by catalyzing a five-electron heme-based oxidation of a guanidine nitrogen of L-arginine to L-citrulline via two successive monooxygenation reactions producing N(omega)-hydroxy-L-arginine (NHA) as an...; Region: NOS_oxygenase; cd00575 358681017043 active site 358681017044 dimer interface [polypeptide binding]; other site 358681017045 Glycerol-3-phosphate responsive antiterminator; Region: G3P_antiterm; cl00852 358681017046 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 358681017047 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cl12060 358681017048 Metal-binding active site; metal-binding site 358681017049 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 358681017050 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 358681017051 dimer interface [polypeptide binding]; other site 358681017052 conserved gate region; other site 358681017053 putative PBP binding loops; other site 358681017054 ABC-ATPase subunit interface; other site 358681017055 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 358681017056 dimer interface [polypeptide binding]; other site 358681017057 conserved gate region; other site 358681017058 putative PBP binding loops; other site 358681017059 ABC-ATPase subunit interface; other site 358681017060 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 358681017061 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 358681017062 ABC-type sugar transport systems, ATPase components [Carbohydrate transport and metabolism]; Region: MalK; COG3839 358681017063 The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301 358681017064 Walker A/P-loop; other site 358681017065 ATP binding site [chemical binding]; other site 358681017066 Q-loop/lid; other site 358681017067 ABC transporter signature motif; other site 358681017068 Walker B; other site 358681017069 D-loop; other site 358681017070 H-loop/switch region; other site 358681017071 TOBE domain; Region: TOBE; pfam03459 358681017072 Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584 358681017073 Catalytic domain of phosphoinositide-specific phospholipase C-like phosphodiesterases superfamily; Region: PI-PLCc_GDPD_SF; cl14615 358681017074 active site 358681017075 catalytic site [active] 358681017076 Predicted sugar phosphatases of the HAD superfamily [Carbohydrate transport and metabolism]; Region: NagD; COG0647 358681017077 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 358681017078 active site 358681017079 motif I; other site 358681017080 motif II; other site 358681017081 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 358681017082 Imelysin; Region: Peptidase_M75; pfam09375 358681017083 Tat-translocated enzyme; Region: tat_substr_1; TIGR01412 358681017084 Predicted iron-dependent peroxidase [Inorganic ion transport and metabolism]; Region: COG2837 358681017085 High-affinity Fe2+/Pb2+ permease [Inorganic ion transport and metabolism]; Region: FTR1; COG0672 358681017086 cadmium resistance transporter (or sequestration) family protein; Region: cad; TIGR00779 358681017087 phosphoribose diphosphate:decaprenyl-phosphate phosphoribosyltransferase; Provisional; Region: PRK12324 358681017088 4-amino-4-deoxy-L-arabinose-phosphoundecaprenol flippase subunit ArnF; Provisional; Region: PRK02971 358681017089 Divergent PAP2 family; Region: DUF212; pfam02681 358681017090 OsmC-like protein; Region: OsmC; pfam02566 358681017091 undecaprenyl pyrophosphate phosphatase; Reviewed; Region: PRK00281 358681017092 The GH18 (glycosyl hydrolase, family 18) type II chitinases hydrolyze chitin, an abundant polymer of beta-1,4-linked N-acetylglucosamine (GlcNAc) which is a major component of the cell wall of fungi and the exoskeleton of arthropods. Chitinases have...; Region: GH18_chitinase-like; cl10447 358681017093 active site 358681017094 Catalytic NodB homology domain of the carbohydrate esterase 4 superfamily; Region: CE4_SF; cl15692 358681017095 Catalytic NodB homology domain of the carbohydrate esterase 4 superfamily; Region: CE4_SF; cl15692 358681017096 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 358681017097 CESA_like is the cellulose synthase superfamily; Region: CESA_like; cd06423 358681017098 DXD motif; other site 358681017099 UDP-N-acetyl-D-mannosaminuronate dehydrogenase [Cell envelope biogenesis, outer membrane]; Region: WecC; COG0677 358681017100 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 358681017101 UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984 358681017102 UDP binding domain; Region: UDPG_MGDP_dh_C; smart00984 358681017103 Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726 358681017104 Catalytic NodB homology domain of rhizobial NodB-like proteins; Region: CE4_NodB_like_6s_7s; cd10917 358681017105 NodB motif; other site 358681017106 active site 358681017107 metal binding site [ion binding]; metal-binding site 358681017108 Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726 358681017109 Catalytic NodB homology domain of rhizobial NodB-like proteins; Region: CE4_NodB_like_6s_7s; cd10917 358681017110 NodB motif; other site 358681017111 active site 358681017112 catalytic site [active] 358681017113 metal binding site [ion binding]; metal-binding site 358681017114 Uncharacterized ALDH (y4uC) with similarity to Tortula ruralis aldehyde dehydrogenase ALDH21A1; Region: ALDH_y4uC; cd07149 358681017115 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 358681017116 NAD(P) binding site [chemical binding]; other site 358681017117 catalytic residues [active] 358681017118 4-aminobutyrate aminotransferase; Reviewed; Region: PRK06918 358681017119 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 358681017120 inhibitor-cofactor binding pocket; inhibition site 358681017121 pyridoxal 5'-phosphate binding site [chemical binding]; other site 358681017122 catalytic residue [active] 358681017123 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459 358681017124 PAS domain; Region: PAS_9; pfam13426 358681017125 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 358681017126 psp operon transcriptional activator PspF; Region: phageshock_pspF; TIGR02974 358681017127 Walker A motif; other site 358681017128 ATP binding site [chemical binding]; other site 358681017129 Walker B motif; other site 358681017130 arginine finger; other site 358681017131 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 358681017132 Methyltransferase domain; Region: Methyltransf_31; pfam13847 358681017133 Penicillinase repressor; Region: Pencillinase_R; pfam03965 358681017134 BlaR1 peptidase M56; Region: Peptidase_M56; pfam05569 358681017135 Peptidase family M23; Region: Peptidase_M23; pfam01551 358681017136 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 358681017137 Arylamine N-acetyltransferase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: NhoA; COG2162 358681017138 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204 358681017139 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 358681017140 Walker A motif; other site 358681017141 ATP binding site [chemical binding]; other site 358681017142 Walker B motif; other site 358681017143 arginine finger; other site 358681017144 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 358681017145 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 358681017146 classical (c) SDRs; Region: SDR_c; cd05233 358681017147 NAD(P) binding site [chemical binding]; other site 358681017148 active site 358681017149 Glycine cleavage system protein P (pyridoxal-binding), N-terminal domain [Amino acid transport and metabolism]; Region: GcvP; COG0403 358681017150 glycine dehydrogenase subunit 1; Validated; Region: PRK00451 358681017151 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 358681017152 catalytic residue [active] 358681017153 glycine dehydrogenase subunit 2; Validated; Region: PRK04366 358681017154 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 358681017155 catalytic residue [active] 358681017156 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 358681017157 MarR family; Region: MarR; pfam01047 358681017158 MarR family; Region: MarR_2; cl17246 358681017159 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 358681017160 putative substrate translocation pore; other site 358681017161 Predicted membrane protein [Function unknown]; Region: COG1511 358681017162 YhgE/Pip N-terminal domain; Region: pip_yhgE_Nterm; TIGR03061 358681017163 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 358681017164 Putative zinc-finger; Region: zf-HC2; pfam13490 358681017165 Domain of unknown function (DUF4179); Region: DUF4179; pfam13786 358681017166 DNA-directed RNA polymerase specialized sigma subunit, sigma24 homolog [Transcription]; Region: RpoE; COG1595 358681017167 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 358681017168 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 358681017169 DNA binding residues [nucleotide binding] 358681017170 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 358681017171 MarR family; Region: MarR; pfam01047 358681017172 peroxiredoxin, Ohr subfamily; Region: organ_hyd_perox; TIGR03561 358681017173 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312 358681017174 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 358681017175 substrate binding pocket [chemical binding]; other site 358681017176 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 358681017177 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 358681017178 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 358681017179 ABC-ATPase subunit interface; other site 358681017180 dimer interface [polypeptide binding]; other site 358681017181 putative PBP binding regions; other site 358681017182 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 358681017183 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 358681017184 ABC-ATPase subunit interface; other site 358681017185 dimer interface [polypeptide binding]; other site 358681017186 putative PBP binding regions; other site 358681017187 ABC-type Fe3+-citrate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FecB; COG4594 358681017188 Fe3+-siderophore binding domain FhuD. These proteins have been shown to function as initial receptors in ABC transport of Fe3+-siderophores in many eubacterial species. They belong to the TroA-like superfamily of helical backbone metal receptor proteins...; Region: FhuD; cd01146 358681017189 siderophore binding site; other site 358681017190 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 358681017191 UDP-glucose LOS-beta-1,4 glucosyltransferase is required for biosynthesis of lipooligosaccharide; Region: Beta4Glucosyltransferase; cd02511 358681017192 putative metal binding site; other site 358681017193 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 358681017194 TPR motif; other site 358681017195 TPR repeat; Region: TPR_11; pfam13414 358681017196 binding surface 358681017197 Methyltransferase domain; Region: Methyltransf_23; pfam13489 358681017198 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 358681017199 S-adenosylmethionine binding site [chemical binding]; other site 358681017200 BofC C-terminal domain; Region: BofC_C; pfam08955 358681017201 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 358681017202 active site 358681017203 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 358681017204 Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491 358681017205 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 358681017206 UDP-glucose LOS-beta-1,4 glucosyltransferase is required for biosynthesis of lipooligosaccharide; Region: Beta4Glucosyltransferase; cd02511 358681017207 putative metal binding site; other site 358681017208 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 358681017209 binding surface 358681017210 TPR motif; other site 358681017211 Uncharacterized Zn-ribbon-containing protein involved in phosphonate metabolism [Inorganic ion transport and metabolism]; Region: PhnA; COG2824 358681017212 PhnA Zinc-Ribbon; Region: PhnA_Zn_Ribbon; pfam08274 358681017213 PhnA protein; Region: PhnA; pfam03831 358681017214 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 358681017215 Histidine kinase; Region: HisKA_3; pfam07730 358681017216 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 358681017217 ATP binding site [chemical binding]; other site 358681017218 Mg2+ binding site [ion binding]; other site 358681017219 G-X-G motif; other site 358681017220 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 358681017221 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 358681017222 active site 358681017223 phosphorylation site [posttranslational modification] 358681017224 intermolecular recognition site; other site 358681017225 dimerization interface [polypeptide binding]; other site 358681017226 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 358681017227 DNA binding residues [nucleotide binding] 358681017228 dimerization interface [polypeptide binding]; other site 358681017229 Beta-lactamase; Region: Beta-lactamase; pfam00144 358681017230 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 358681017231 Domain of unknown function (DUF373); Region: DUF373; cl12079 358681017232 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 358681017233 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 358681017234 FtsX-like permease family; Region: FtsX; pfam02687 358681017235 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 358681017236 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 358681017237 Walker A/P-loop; other site 358681017238 ATP binding site [chemical binding]; other site 358681017239 Q-loop/lid; other site 358681017240 ABC transporter signature motif; other site 358681017241 Walker B; other site 358681017242 D-loop; other site 358681017243 H-loop/switch region; other site 358681017244 Peptidase family M23; Region: Peptidase_M23; pfam01551 358681017245 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 358681017246 HlyD family secretion protein; Region: HlyD_3; pfam13437 358681017247 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 358681017248 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 358681017249 dimerization interface [polypeptide binding]; other site 358681017250 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 358681017251 dimer interface [polypeptide binding]; other site 358681017252 phosphorylation site [posttranslational modification] 358681017253 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 358681017254 ATP binding site [chemical binding]; other site 358681017255 Mg2+ binding site [ion binding]; other site 358681017256 G-X-G motif; other site 358681017257 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 358681017258 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 358681017259 active site 358681017260 phosphorylation site [posttranslational modification] 358681017261 intermolecular recognition site; other site 358681017262 dimerization interface [polypeptide binding]; other site 358681017263 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 358681017264 DNA binding site [nucleotide binding] 358681017265 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 358681017266 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 358681017267 substrate binding pocket [chemical binding]; other site 358681017268 membrane-bound complex binding site; other site 358681017269 hinge residues; other site 358681017270 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 358681017271 dimer interface [polypeptide binding]; other site 358681017272 conserved gate region; other site 358681017273 putative PBP binding loops; other site 358681017274 ABC-ATPase subunit interface; other site 358681017275 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 358681017276 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 358681017277 Walker A/P-loop; other site 358681017278 ATP binding site [chemical binding]; other site 358681017279 Q-loop/lid; other site 358681017280 ABC transporter signature motif; other site 358681017281 Walker B; other site 358681017282 D-loop; other site 358681017283 H-loop/switch region; other site 358681017284 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 358681017285 Bacterial alpha-L-rhamnosidase; Region: Bac_rhamnosid; pfam05592 358681017286 Protein of unknown function, DUF624; Region: DUF624; cl02369 358681017287 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 358681017288 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 358681017289 dimer interface [polypeptide binding]; other site 358681017290 conserved gate region; other site 358681017291 putative PBP binding loops; other site 358681017292 ABC-ATPase subunit interface; other site 358681017293 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 358681017294 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 358681017295 dimer interface [polypeptide binding]; other site 358681017296 conserved gate region; other site 358681017297 ABC-ATPase subunit interface; other site 358681017298 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 358681017299 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 358681017300 Response regulator receiver domain; Region: Response_reg; pfam00072 358681017301 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 358681017302 active site 358681017303 phosphorylation site [posttranslational modification] 358681017304 intermolecular recognition site; other site 358681017305 dimerization interface [polypeptide binding]; other site 358681017306 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 358681017307 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 358681017308 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 358681017309 Predicted signal transduction protein with a C-terminal ATPase domain [Signal transduction mechanisms]; Region: COG2972 358681017310 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 358681017311 dimerization interface [polypeptide binding]; other site 358681017312 Histidine kinase; Region: His_kinase; pfam06580 358681017313 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 358681017314 ATP binding site [chemical binding]; other site 358681017315 Mg2+ binding site [ion binding]; other site 358681017316 G-X-G motif; other site 358681017317 cryptic beta-D-galactosidase subunit alpha; Reviewed; Region: ebgA; PRK10340 358681017318 Glycosyl hydrolases family 2, sugar binding domain; Region: Glyco_hydro_2_N; pfam02837 358681017319 Glycosyl hydrolases family 2; Region: Glyco_hydro_2; pfam00703 358681017320 Glycosyl hydrolases family 2, TIM barrel domain; Region: Glyco_hydro_2_C; pfam02836 358681017321 Beta galactosidase small chain; Region: Bgal_small_N; smart01038 358681017322 ROK family protein (putative glucokinase); Region: ROK_glcA_fam; TIGR00744 358681017323 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 358681017324 nucleotide binding site [chemical binding]; other site 358681017325 Fructose-1-phosphate kinase and related fructose-6-phosphate kinase (PfkB) [Carbohydrate transport and metabolism]; Region: FruK; COG1105 358681017326 1-phosphofructokinase (FruK), minor 6-phosphofructokinase (pfkB) and related sugar kinases. FruK plays an important role in the predominant pathway for fructose utilisation.This group also contains tagatose-6-phophate kinase, an enzyme of the tagatose...; Region: FruK_PfkB_like; cd01164 358681017327 putative substrate binding site [chemical binding]; other site 358681017328 putative ATP binding site [chemical binding]; other site 358681017329 bifunctional phosphoglucose/phosphomannose isomerase; Validated; Region: PRK08674 358681017330 The members of this protein family contain the SIS (Sugar ISomerase) domain and have both the phosphoglucose isomerase (PGI) and the phosphomannose isomerase (PMI) functions. These functions catalyze the reversible reactions of glucose 6-phosphate to...; Region: SIS_PGI_PMI_1; cd05017 358681017331 dimer interface [polypeptide binding]; other site 358681017332 active site 358681017333 The members of this protein family contain the SIS (Sugar ISomerase) domain and have both the phosphoglucose isomerase (PGI) and the phosphomannose isomerase (PMI) functions. These functions catalyze the reversible reactions of glucose 6-phosphate to...; Region: SIS_PGI_PMI_2; cd05637 358681017334 dimer interface [polypeptide binding]; other site 358681017335 active site 358681017336 Tagatose-1,6-bisphosphate (TBP) aldolase and related Type B Class II aldolases. TBP aldolase is a tetrameric class II aldolase that catalyzes the reversible condensation of dihydroxyacetone phosphate with glyceraldehyde 3-phsophate to produce tagatose 1; Region: TBP_aldolase_IIB; cd00947 358681017337 fructose-bisphosphate aldolase; Provisional; Region: PRK09197 358681017338 intersubunit interface [polypeptide binding]; other site 358681017339 active site 358681017340 zinc binding site [ion binding]; other site 358681017341 Na+ binding site [ion binding]; other site 358681017342 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 358681017343 helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420 358681017344 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 358681017345 Transcriptional regulator [Transcription]; Region: LysR; COG0583 358681017346 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 358681017347 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 358681017348 dimerization interface [polypeptide binding]; other site 358681017349 Putative intracellular protease/amidase [General function prediction only]; Region: ThiJ; COG0693 358681017350 Type 1 glutamine amidotransferase (GATase1)-like domain found in Human DJ-1; Region: GATase1_DJ-1; cd03135 358681017351 conserved cys residue [active] 358681017352 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 358681017353 Histidine kinase; Region: HisKA_3; pfam07730 358681017354 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 358681017355 ATP binding site [chemical binding]; other site 358681017356 Mg2+ binding site [ion binding]; other site 358681017357 G-X-G motif; other site 358681017358 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 358681017359 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 358681017360 active site 358681017361 phosphorylation site [posttranslational modification] 358681017362 intermolecular recognition site; other site 358681017363 dimerization interface [polypeptide binding]; other site 358681017364 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 358681017365 DNA binding residues [nucleotide binding] 358681017366 dimerization interface [polypeptide binding]; other site 358681017367 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 358681017368 Beta-lactamase; Region: Beta-lactamase; pfam00144 358681017369 Putative intracellular protease/amidase [General function prediction only]; Region: ThiJ; COG0693 358681017370 Type 1 glutamine amidotransferase (GATase1)-like domain found in proteins similar to Escherichia coli Hsp31 protein; Region: GATase1_Hsp31_like; cd03141 358681017371 potential catalytic triad [active] 358681017372 conserved cys residue [active] 358681017373 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 358681017374 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 358681017375 putative substrate translocation pore; other site 358681017376 Transcriptional regulator [Transcription]; Region: LysR; COG0583 358681017377 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 358681017378 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 358681017379 dimerization interface [polypeptide binding]; other site 358681017380 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 358681017381 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 358681017382 putative Zn2+ binding site [ion binding]; other site 358681017383 putative DNA binding site [nucleotide binding]; other site 358681017384 N-terminal domain of Sphingobium chlorophenolicum 2,6-dichloro-p-hydroquinone 1,2-dioxygenase (PcpA), and similar proteins; Region: PcpA_N_like; cd08346 358681017385 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 358681017386 Zn binding site [ion binding]; other site 358681017387 C-terminal domain of Sphingobium chlorophenolicum 2,6-dichloro-p-hydroquinone 1,2-dioxygenase (PcpA), and similar proteins; Region: PcpA_C_like; cd08347 358681017388 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 358681017389 Zn binding site [ion binding]; other site 358681017390 putative luciferase-like monooxygenase, FMN-dependent, CE1758 family; Region: LLM_CE1758_fam; TIGR04036 358681017391 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 358681017392 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cd00347 358681017393 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 358681017394 HSP70 interaction site [polypeptide binding]; other site 358681017395 TPR repeat; Region: TPR_11; pfam13414 358681017396 TPR repeat; Region: TPR_11; pfam13414 358681017397 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 358681017398 binding surface 358681017399 TPR motif; other site 358681017400 Tetratricopeptide repeat; Region: TPR_16; pfam13432 358681017401 Protein of unknown function (DUF1266); Region: DUF1266; pfam06889 358681017402 RT_G2_intron: Reverse transcriptases (RTs) with group II intron origin. RT transcribes DNA using RNA as template. Proteins in this subfamily are found in bacterial and mitochondrial group II introns. Their most probable ancestor was a retrotransposable...; Region: RT_G2_intron; cd01651 358681017403 Reverse transcriptase (RNA-dependent DNA polymerase); Region: RVT_1; pfam00078 358681017404 putative active site [active] 358681017405 putative NTP binding site [chemical binding]; other site 358681017406 putative nucleic acid binding site [nucleotide binding]; other site 358681017407 Group II intron, maturase-specific domain; Region: GIIM; pfam08388 358681017408 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 358681017409 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 358681017410 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 358681017411 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 358681017412 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 358681017413 Coenzyme A binding pocket [chemical binding]; other site 358681017414 atypical (a) SDRs, subgroup 8; Region: SDR_a8; cd05242 358681017415 TIGR01777 family protein; Region: yfcH 358681017416 putative NAD(P) binding site [chemical binding]; other site 358681017417 putative active site [active] 358681017418 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 358681017419 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 358681017420 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 358681017421 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 358681017422 active site 358681017423 Uncharacterized protein family UPF0027; Region: UPF0027; pfam01139 358681017424 hypothetical protein; Reviewed; Region: PRK09588 358681017425 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 358681017426 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 358681017427 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 358681017428 Ankyrin repeats (many copies); Region: Ank_4; pfam13637 358681017429 Peptidase inhibitor I9; Region: Inhibitor_I9; pfam05922 358681017430 Subtilisin-like serine proteases [Posttranslational modification, protein turnover, chaperones]; Region: AprE; COG1404 358681017431 Peptidase S8 family domain in Vpr-like proteins; Region: Peptidases_S8_subtilisin_Vpr-like; cd07474 358681017432 putative active site [active] 358681017433 catalytic triad [active] 358681017434 PA_C5a_like: Protease-associated domain containing proteins like Streptococcus pyogenes C5a peptidase. This group contains various PA domain-containing proteins similar to S. pyogenes C5a, including, i) Vpr, a minor extracellular serine protease from...; Region: PA_C5a_like; cd02133 358681017435 putative integrin binding motif; other site 358681017436 PA/protease domain interface [polypeptide binding]; other site 358681017437 Peptidase S8 family domain in Vpr-like proteins; Region: Peptidases_S8_subtilisin_Vpr-like; cd07474 358681017438 Fn3-like domain (DUF1034); Region: DUF1034; pfam06280 358681017439 Phosphoenolpyruvate-protein kinase (PTS system EI component in bacteria) [Carbohydrate transport and metabolism]; Region: PtsA; COG1080 358681017440 PEP-utilising enzyme, N-terminal; Region: PEP-utilisers_N; pfam05524 358681017441 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 358681017442 PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896 358681017443 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367 358681017444 dimerization domain swap beta strand [polypeptide binding]; other site 358681017445 regulatory protein interface [polypeptide binding]; other site 358681017446 active site 358681017447 regulatory phosphorylation site [posttranslational modification]; other site 358681017448 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 358681017449 PTS system 2-O-a-mannosyl-D-glycerate specific transporter subunit IIABC; Provisional; Region: PRK09765 358681017450 active site 358681017451 phosphorylation site [posttranslational modification] 358681017452 PTS_IIB_fructose: subunit IIB of enzyme II (EII) of the fructose-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII (also referred to as FruAB) is a fructose-specific permease made up of two proteins (FruA and...; Region: PTS_IIB_fructose; cd05569 358681017453 active site 358681017454 P-loop; other site 358681017455 phosphorylation site [posttranslational modification] 358681017456 Phosphotransferase system, fructose-specific IIC component [Carbohydrate transport and metabolism]; Region: FruA; COG1299 358681017457 Fructose-1-phosphate kinase and related fructose-6-phosphate kinase (PfkB) [Carbohydrate transport and metabolism]; Region: FruK; COG1105 358681017458 1-phosphofructokinase (FruK), minor 6-phosphofructokinase (pfkB) and related sugar kinases. FruK plays an important role in the predominant pathway for fructose utilisation.This group also contains tagatose-6-phophate kinase, an enzyme of the tagatose...; Region: FruK_PfkB_like; cd01164 358681017459 putative substrate binding site [chemical binding]; other site 358681017460 putative ATP binding site [chemical binding]; other site 358681017461 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 358681017462 helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420 358681017463 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 358681017464 ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614 358681017465 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 358681017466 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 358681017467 malate:quinone oxidoreductase; Validated; Region: PRK05257 358681017468 malate:quinone-oxidoreductase; Region: mal_quin_oxido; TIGR01320 358681017469 Domain of unknown function (DUF4375); Region: DUF4375; pfam14300 358681017470 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 358681017471 binding surface 358681017472 Tetratricopeptide repeat; Region: TPR_16; pfam13432 358681017473 TPR motif; other site 358681017474 SMI1 / KNR4 family; Region: SMI1_KNR4; smart00860 358681017475 sulfite reductase subunit beta; Provisional; Region: PRK13504 358681017476 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 358681017477 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 358681017478 sulfite reductase [NADPH] flavoprotein, alpha-component; Region: cysJ; TIGR01931 358681017479 Flavodoxin; Region: Flavodoxin_1; pfam00258 358681017480 Cytochrome p450- like alpha subunits of E. coli sulfite reductase (SiR) multimerize with beta subunits to catalyze the NADPH dependent reduction of sulfite to sulfide. Beta subunits have an Fe4S4 cluster and a siroheme, while the alpha subunits (cysJ...; Region: SiR; cd06199 358681017481 FAD binding pocket [chemical binding]; other site 358681017482 FAD binding motif [chemical binding]; other site 358681017483 catalytic residues [active] 358681017484 NAD binding pocket [chemical binding]; other site 358681017485 phosphate binding motif [ion binding]; other site 358681017486 beta-alpha-beta structure motif; other site 358681017487 Glycosyl hydrolases family 2, sugar binding domain; Region: Glyco_hydro_2_N; pfam02837 358681017488 7TM diverse intracellular signalling; Region: 7TMR-DISM_7TM; pfam07695 358681017489 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 358681017490 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 358681017491 dimer interface [polypeptide binding]; other site 358681017492 phosphorylation site [posttranslational modification] 358681017493 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 358681017494 ATP binding site [chemical binding]; other site 358681017495 Mg2+ binding site [ion binding]; other site 358681017496 G-X-G motif; other site 358681017497 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 358681017498 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 358681017499 active site 358681017500 phosphorylation site [posttranslational modification] 358681017501 intermolecular recognition site; other site 358681017502 dimerization interface [polypeptide binding]; other site 358681017503 Predicted signal transduction protein with a C-terminal ATPase domain [Signal transduction mechanisms]; Region: COG2972 358681017504 Histidine kinase; Region: His_kinase; pfam06580 358681017505 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 358681017506 ATP binding site [chemical binding]; other site 358681017507 Mg2+ binding site [ion binding]; other site 358681017508 G-X-G motif; other site 358681017509 O-Methyltransferase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3315 358681017510 Leucine carboxyl methyltransferase; Region: LCM; pfam04072 358681017511 Domain of unknown function (DUF4343); Region: DUF4343; pfam14243 358681017512 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 358681017513 salt bridge; other site 358681017514 non-specific DNA binding site [nucleotide binding]; other site 358681017515 sequence-specific DNA binding site [nucleotide binding]; other site 358681017516 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 358681017517 short chain dehydrogenase; Provisional; Region: PRK07041 358681017518 NAD(P) binding site [chemical binding]; other site 358681017519 active site 358681017520 Transposase domain (DUF772); Region: DUF772; pfam05598 358681017521 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 358681017522 Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751 358681017523 Protein of unknown function (DUF1211); Region: DUF1211; cl01421 358681017524 tellurite resistance protein terB; Region: terB; cd07176 358681017525 putative metal binding site [ion binding]; other site 358681017526 HpcH/HpaI aldolase/citrate lyase family; Region: HpcH_HpaI; cl17231 358681017527 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 358681017528 active site 358681017529 Protein of unknown function (DUF3706); Region: DUF3706; pfam12500 358681017530 Protein of unknown function (DUF2983); Region: DUF2983; pfam11202 358681017531 Sucrose-6F-phosphate phosphohydrolase; Region: S6PP; pfam05116 358681017532 Uncharacterized proteins involved in stress response, homologs of TerZ and putative cAMP-binding protein CABP1 [Signal transduction mechanisms]; Region: TerZ; COG2310 358681017533 Uncharacterized proteins involved in stress response, similar to tellurium resistance terD; Region: TerD_like; cd06974 358681017534 putative metal binding site [ion binding]; other site 358681017535 Uncharacterized proteins involved in stress response, homologs of TerZ and putative cAMP-binding protein CABP1 [Signal transduction mechanisms]; Region: TerZ; COG2310 358681017536 Uncharacterized proteins involved in stress response, similar to tellurium resistance terD; Region: TerD_like; cd06974 358681017537 putative metal binding site [ion binding]; other site 358681017538 Tellurium resistance protein; Region: Tellurium_res; pfam10138 358681017539 Uncharacterized proteins involved in stress response, homologs of TerZ and putative cAMP-binding protein CABP1 [Signal transduction mechanisms]; Region: TerZ; COG2310 358681017540 Uncharacterized proteins involved in stress response, similar to tellurium resistance terD; Region: TerD_like; cd06974 358681017541 putative metal binding site [ion binding]; other site 358681017542 Uncharacterized proteins involved in stress response, homologs of TerZ and putative cAMP-binding protein CABP1 [Signal transduction mechanisms]; Region: TerZ; COG2310 358681017543 Uncharacterized proteins involved in stress response, similar to tellurium resistance terD; Region: TerD_like; cd06974 358681017544 putative metal binding site [ion binding]; other site 358681017545 Uncharacterized protein involved in stress response [General function prediction only]; Region: COG4110 358681017546 Uncharacterized proteins involved in stress response, similar to tellurium resistance terD; Region: TerD_like; cd06974 358681017547 putative metal binding site [ion binding]; other site 358681017548 integral membrane protein, YkoY family; Region: R_switched_YkoY; TIGR03716 358681017549 ATP-grasp domain; Region: ATP-grasp_4; pfam13535 358681017550 S-layer homology domain; Region: SLH; pfam00395 358681017551 S-layer homology domain; Region: SLH; pfam00395 358681017552 S-layer homology domain; Region: SLH; pfam00395 358681017553 7TM diverse intracellular signalling; Region: 7TMR-DISM_7TM; pfam07695 358681017554 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 358681017555 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 358681017556 dimer interface [polypeptide binding]; other site 358681017557 phosphorylation site [posttranslational modification] 358681017558 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 358681017559 ATP binding site [chemical binding]; other site 358681017560 Mg2+ binding site [ion binding]; other site 358681017561 G-X-G motif; other site 358681017562 Response regulator receiver domain; Region: Response_reg; pfam00072 358681017563 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 358681017564 active site 358681017565 phosphorylation site [posttranslational modification] 358681017566 intermolecular recognition site; other site 358681017567 dimerization interface [polypeptide binding]; other site 358681017568 Predicted signal transduction protein with a C-terminal ATPase domain [Signal transduction mechanisms]; Region: COG2972 358681017569 Histidine kinase; Region: His_kinase; pfam06580 358681017570 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 358681017571 ATP binding site [chemical binding]; other site 358681017572 Mg2+ binding site [ion binding]; other site 358681017573 G-X-G motif; other site 358681017574 Response regulator containing CheY-like receiver and SARP domains [Signal transduction mechanisms]; Region: COG3947 358681017575 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 358681017576 active site 358681017577 phosphorylation site [posttranslational modification] 358681017578 intermolecular recognition site; other site 358681017579 dimerization interface [polypeptide binding]; other site 358681017580 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cl17355 358681017581 Predicted transcriptional regulators [Transcription]; Region: COG1733 358681017582 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 358681017583 Arginate lyase and other MDR family members; Region: AL_MDR; cd08252 358681017584 zinc-binding alcohol dehydrogenase family protein; Region: adh_fam_1; TIGR02817 358681017585 putative NAD(P) binding site [chemical binding]; other site 358681017586 dimer interface [polypeptide binding]; other site 358681017587 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 358681017588 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 358681017589 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 358681017590 dimer interface [polypeptide binding]; other site 358681017591 phosphorylation site [posttranslational modification] 358681017592 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 358681017593 ATP binding site [chemical binding]; other site 358681017594 Mg2+ binding site [ion binding]; other site 358681017595 G-X-G motif; other site 358681017596 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 358681017597 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 358681017598 active site 358681017599 phosphorylation site [posttranslational modification] 358681017600 intermolecular recognition site; other site 358681017601 dimerization interface [polypeptide binding]; other site 358681017602 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 358681017603 DNA binding site [nucleotide binding] 358681017604 Interphotoreceptor retinoid-binding protein; serine protease family S41; Region: Peptidase_S41_IRBP; cd07563 358681017605 active site triad [active] 358681017606 Domain of unknown function (DUF4062); Region: DUF4062; pfam13271 358681017607 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 358681017608 Uncharacterized homolog of gamma-carboxymuconolactone decarboxylase subunit [Function unknown]; Region: COG0599 358681017609 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 358681017610 Major Facilitator Superfamily; Region: MFS_1; pfam07690 358681017611 putative substrate translocation pore; other site 358681017612 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 358681017613 salt bridge; other site 358681017614 non-specific DNA binding site [nucleotide binding]; other site 358681017615 sequence-specific DNA binding site [nucleotide binding]; other site 358681017616 Cache domain; Region: Cache_1; pfam02743 358681017617 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 358681017618 dimerization interface [polypeptide binding]; other site 358681017619 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 358681017620 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 358681017621 dimer interface [polypeptide binding]; other site 358681017622 putative CheW interface [polypeptide binding]; other site 358681017623 alpha-acetolactate decarboxylase; Region: acetolac_decarb; TIGR01252 358681017624 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 358681017625 binding surface 358681017626 TPR motif; other site 358681017627 Domain of unknown function (DUF4303); Region: DUF4303; pfam14136 358681017628 Protein of unknown function (DUF2785); Region: DUF2785; pfam10978 358681017629 Predicted transcriptional regulator [Transcription]; Region: COG2378 358681017630 HTH domain; Region: HTH_11; pfam08279 358681017631 WYL domain; Region: WYL; pfam13280 358681017632 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 358681017633 putative DNA binding site [nucleotide binding]; other site 358681017634 dimerization interface [polypeptide binding]; other site 358681017635 putative Zn2+ binding site [ion binding]; other site 358681017636 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 358681017637 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 358681017638 putative substrate translocation pore; other site 358681017639 rRNA large subunit methyltransferase; Provisional; Region: PRK00103 358681017640 CxxH/CxxC protein, BA_5709 family; Region: CxxH_BA5709; TIGR04129 358681017641 Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]; Region: DegQ; COG0265 358681017642 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 358681017643 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 358681017644 protein binding site [polypeptide binding]; other site 358681017645 Nitrile hydratase beta subunit; Region: NHase_beta; pfam02211 358681017646 Metal-dependent hydrolases of the beta-lactamase superfamily I [General function prediction only]; Region: PhnP; COG1235 358681017647 YycH protein; Region: YycI; cl02015 358681017648 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4863 358681017649 YycH protein; Region: YycH; pfam07435 358681017650 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: VicK; COG5002 358681017651 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 358681017652 dimerization interface [polypeptide binding]; other site 358681017653 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 358681017654 putative active site [active] 358681017655 heme pocket [chemical binding]; other site 358681017656 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 358681017657 dimer interface [polypeptide binding]; other site 358681017658 phosphorylation site [posttranslational modification] 358681017659 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 358681017660 ATP binding site [chemical binding]; other site 358681017661 Mg2+ binding site [ion binding]; other site 358681017662 G-X-G motif; other site 358681017663 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 358681017664 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 358681017665 active site 358681017666 phosphorylation site [posttranslational modification] 358681017667 intermolecular recognition site; other site 358681017668 dimerization interface [polypeptide binding]; other site 358681017669 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 358681017670 DNA binding site [nucleotide binding] 358681017671 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 358681017672 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 358681017673 G5 domain; Region: G5; pfam07501 358681017674 Peptidase family M23; Region: Peptidase_M23; pfam01551 358681017675 Adenylosuccinate synthetase; Region: Adenylsucc_synt; smart00788 358681017676 Adenylosuccinate synthetase (AdSS) catalyzes the first step in the de novo biosynthesis of AMP. IMP and L-aspartate are conjugated in a two-step reaction accompanied by the hydrolysis of GTP to GDP in the presence of Mg2+. In the first step, the...; Region: AdSS; cd03108 358681017677 GDP-binding site [chemical binding]; other site 358681017678 ACT binding site; other site 358681017679 IMP binding site; other site 358681017680 replicative DNA helicase; Provisional; Region: PRK05748 358681017681 DnaB-like helicase N terminal domain; Region: DnaB; pfam00772 358681017682 DnaB helicase C terminal domain. The hexameric helicase DnaB unwinds the DNA duplex at the chromosome replication fork. Although the mechanism by which DnaB both couples ATP hydrolysis to translocation along DNA and denatures the duplex is unknown, a...; Region: DnaB_C; cd00984 358681017683 Walker A motif; other site 358681017684 ATP binding site [chemical binding]; other site 358681017685 Walker B motif; other site 358681017686 DNA binding loops [nucleotide binding] 358681017687 50S ribosomal protein L9; Reviewed; Region: rplI; PRK00137 358681017688 Ribosomal protein L9, N-terminal domain; Region: Ribosomal_L9_N; pfam01281 358681017689 Ribosomal protein L9, C-terminal domain; Region: Ribosomal_L9_C; pfam03948 358681017690 Predicted signaling protein consisting of a modified GGDEF domain and a DHH domain [Signal transduction mechanisms]; Region: COG3887 358681017691 Class III nucleotidyl cyclases; Region: Nucleotidyl_cyc_III; cl11967 358681017692 DHH family; Region: DHH; pfam01368 358681017693 Predicted membrane protein (DUF2232); Region: DUF2232; pfam09991 358681017694 30S ribosomal protein S18; Reviewed; Region: rpsR; PRK00391 358681017695 Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629 358681017696 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 358681017697 dimer interface [polypeptide binding]; other site 358681017698 ssDNA binding site [nucleotide binding]; other site 358681017699 tetramer (dimer of dimers) interface [polypeptide binding]; other site 358681017700 30S ribosomal protein S6; Reviewed; Region: rpsF; PRK00453 358681017701 GTP-binding protein YchF; Reviewed; Region: PRK09601 358681017702 YchF GTPase; Region: YchF; cd01900 358681017703 G1 box; other site 358681017704 GTP/Mg2+ binding site [chemical binding]; other site 358681017705 Switch I region; other site 358681017706 G2 box; other site 358681017707 Switch II region; other site 358681017708 G3 box; other site 358681017709 G4 box; other site 358681017710 G5 box; other site 358681017711 TGS_YchF_C: This subfamily represents TGS domain-containing YchF GTP-binding protein, a universally conserved GTPase whose function is unknown. The N-terminal domain of the YchF protein belongs to the Obg-like family of GTPases, and some members of the...; Region: TGS_YchF_C; cd04867 358681017712 biliverdin IX beta reductase (BVR-B, aka flavin reductase)-like proteins; atypical (a) SDRs; Region: BVR-B_like_SDR_a; cd05244 358681017713 NADH(P)-binding; Region: NAD_binding_10; pfam13460 358681017714 NAD binding site [chemical binding]; other site 358681017715 substrate binding site [chemical binding]; other site 358681017716 putative active site [active] 358681017717 oligoendopeptidase F; Region: pepF; TIGR00181 358681017718 Peptidase family M3B Oligopeptidase F (PepF); Region: M3B_PepF_3; cd09608 358681017719 active site 358681017720 Zn binding site [ion binding]; other site 358681017721 Bacterial Ig-like domain; Region: Big_5; pfam13205 358681017722 Bacterial Ig-like domain; Region: Big_5; pfam13205 358681017723 Bacterial protein of unknown function (DUF951); Region: DUF951; pfam06107 358681017724 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 358681017725 Mechanosensitive ion channel; Region: MS_channel; pfam00924 358681017726 Protein of unknown function (DUF3343); Region: DUF3343; pfam11823 358681017727 Protein of unknown function (DUF1256); Region: DUF1256; cl06087 358681017728 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; pfam00781 358681017729 Sphingosine kinase and enzymes related to eukaryotic diacylglycerol kinase [Lipid metabolism / General function prediction only]; Region: LCB5; COG1597 358681017730 Diacylglycerol kinase accessory domain; Region: DAGK_acc; cl02440 358681017731 Protein of unknown function (DUF554); Region: DUF554; pfam04474 358681017732 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 358681017733 Cysteine desulfurase (SufS)-like. This family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to cysteine desulfurase (SufS) and selenocysteine lyase. SufS...; Region: SufS_like; cd06453 358681017734 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 358681017735 catalytic residue [active] 358681017736 Stage 0 sporulation protein J (antagonist of Soj) containing ParB-like nuclease domain [Transcription]; Region: Spo0J; COG1475 358681017737 ParB-like nuclease domain; Region: ParB; smart00470 358681017738 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 358681017739 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 358681017740 P-loop; other site 358681017741 Magnesium ion binding site [ion binding]; other site 358681017742 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 358681017743 nucleoid occlusion protein; Region: nucleoid_noc; TIGR04285 358681017744 ParB-like nuclease domain; Region: ParB; smart00470 358681017745 Predicted S-adenosylmethionine-dependent methyltransferase involved in bacterial cell division [Cell envelope biogenesis, outer membrane]; Region: GidB; COG0357 358681017746 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 358681017747 S-adenosylmethionine binding site [chemical binding]; other site 358681017748 tRNA uridine 5-carboxymethylaminomethyl modification enzyme GidA; Validated; Region: PRK05192 358681017749 tRNA (uracil-5-)-methyltransferase Gid; Reviewed; Region: PRK05335 358681017750 GidA associated domain 3; Region: GIDA_assoc_3; pfam13932 358681017751 tRNA modification GTPase TrmE; Reviewed; Region: trmE; PRK05291 358681017752 GTP-binding protein TrmE N-terminus; Region: TrmE_N; pfam10396 358681017753 trmE is a tRNA modification GTPase; Region: trmE; cd04164 358681017754 G1 box; other site 358681017755 GTP/Mg2+ binding site [chemical binding]; other site 358681017756 Switch I region; other site 358681017757 G2 box; other site 358681017758 Switch II region; other site 358681017759 G3 box; other site 358681017760 G4 box; other site 358681017761 G5 box; other site 358681017762 Catalytic cysteine-containing C-terminus of GTPase, MnmE; Region: GTPase_Cys_C; pfam12631 358681017763 Predicted RNA-binding protein [General function prediction only]; Region: Jag; COG1847 358681017764 jag_K homology RNA-binding domain. The KH domain is found in proteins homologous to the Bacillus subtilis protein Jag, which is associated with SpoIIIJ and is necessary for the third stage of sporulation. The KH motif is a beta-alpha-alpha-beta-beta...; Region: jag_KH; cd02414 358681017765 G-X-X-G motif; other site 358681017766 R3H domain found in proteins homologous to Bacillus subtilus Jag, which is associated with SpoIIIJ. SpoIIIJ is necessary for the third stage of sporulation. The name of the R3H domain comes from the characteristic spacing of the most conserved arginine...; Region: R3H_jag; cd02644 358681017767 RxxxH motif; other site 358681017768 60Kd inner membrane protein; Region: 60KD_IMP; cl00489 358681017769 Preprotein translocase subunit YidC [Intracellular trafficking and secretion]; Region: YidC; COG0706 358681017770 Haemolytic domain; Region: Haemolytic; pfam01809 358681017771 ribonuclease P; Reviewed; Region: rnpA; PRK00499 358681017772 50S ribosomal protein L34; Reviewed; Region: rpmH; PRK00399