-- dump date   	20140619_010107
-- class       	Genbank::misc_feature
-- table       	misc_feature_note
-- id	note
633149000001	DnaA N-terminal domain; Region: DnaA_N; pfam11638
633149000002	chromosomal replication initiator protein DnaA; Region: DnaA; TIGR00362
633149000003	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
633149000004	Walker A motif; other site
633149000005	ATP binding site [chemical binding]; other site
633149000006	Walker B motif; other site
633149000007	arginine finger; other site
633149000008	C-terminal domain of bacterial DnaA proteins. The DNA-binding C-terminal domain of DnaA contains a helix-turn-helix motif that specifically interacts with the DnaA box, a 9-mer motif that occurs repetitively in the replication origin oriC. Multiple...; Region: Bac_DnaA_C; cd06571
633149000009	DnaA box-binding interface [nucleotide binding]; other site
633149000010	DNA polymerase III subunit beta; Validated; Region: PRK05643
633149000011	Beta clamp domain.  The beta subunit (processivity factor) of DNA polymerase III holoenzyme, refered to as the beta clamp, forms a ring shaped dimer that encircles dsDNA (sliding clamp) in bacteria.  The beta-clamp is structurally similar to the trimeric...; Region: beta_clamp; cd00140
633149000012	putative DNA binding surface [nucleotide binding]; other site
633149000013	dimer interface [polypeptide binding]; other site
633149000014	beta-clamp/clamp loader binding surface; other site
633149000015	beta-clamp/translesion DNA polymerase binding surface; other site
633149000016	Protein of unknown function (DUF1311); Region: DUF1311; pfam07007
633149000017	recombination protein F; Reviewed; Region: recF; PRK00064
633149000018	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
633149000019	Walker A/P-loop; other site
633149000020	ATP binding site [chemical binding]; other site
633149000021	Q-loop/lid; other site
633149000022	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
633149000023	ABC transporter signature motif; other site
633149000024	Walker B; other site
633149000025	D-loop; other site
633149000026	H-loop/switch region; other site
633149000027	Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; cl10482
633149000028	Sodium/hydrogen exchanger family; Region: Na_H_Exchanger; pfam00999
633149000029	DNA gyrase subunit B; Provisional; Region: gyrB; PRK14939
633149000030	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
633149000031	Mg2+ binding site [ion binding]; other site
633149000032	G-X-G motif; other site
633149000033	TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822
633149000034	anchoring element; other site
633149000035	dimer interface [polypeptide binding]; other site
633149000036	ATP binding site [chemical binding]; other site
633149000037	TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of the...; Region: TOPRIM_TopoIIA_GyrB; cd03366
633149000038	active site
633149000039	putative metal-binding site [ion binding]; other site
633149000040	DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986
633149000041	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
633149000042	Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248
633149000043	active site
633149000044	catalytic tetrad [active]
633149000045	Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596
633149000046	Putative lysophospholipase; Region: Hydrolase_4; pfam12146
633149000047	Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695
633149000048	Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596
633149000049	Pirin-related protein [General function prediction only]; Region: COG1741
633149000050	Pirin; Region: Pirin; pfam02678
633149000051	Pirin C-terminal cupin domain; Region: Pirin_C; pfam05726
633149000052	Protein of unknown function (DUF1697); Region: DUF1697; cl01557
633149000053	formamidopyrimidine/5-formyluracil/ 5-hydroxymethyluracil DNA glycosylase; Validated; Region: PRK01103
633149000054	N-terminal domain of Escherichia coli Fpg1/MutM and related bacterial DNA glycosylases; Region: EcFpg-like_N; cd08966
633149000055	DNA binding site [nucleotide binding]
633149000056	catalytic residue [active]
633149000057	H2TH interface [polypeptide binding]; other site
633149000058	putative catalytic residues [active]
633149000059	turnover-facilitating residue; other site
633149000060	intercalation triad [nucleotide binding]; other site
633149000061	8OG recognition residue [nucleotide binding]; other site
633149000062	putative reading head residues; other site
633149000063	Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831
633149000064	Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827
633149000065	PAP2_like_6 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which mainly contains bacterial proteins, lacks functional characterization and may act as a membrane-associated lipid phosphatase; Region: PAP2_like_6; cd03396
633149000066	active site
633149000067	Predicted membrane protein [Function unknown]; Region: COG1297
633149000068	putative oligopeptide transporter, OPT family; Region: TIGR00733
633149000069	Cytochrome C' Region: Cytochrom_C_2; pfam01322
633149000070	Predicted membrane GTPase involved in stress response [Signal transduction mechanisms]; Region: TypA; COG1217
633149000071	Tyrosine phosphorylated protein A (TypA)/BipA family belongs to ribosome-binding GTPases; Region: TypA_BipA; cd01891
633149000072	G1 box; other site
633149000073	putative GEF interaction site [polypeptide binding]; other site
633149000074	GTP/Mg2+ binding site [chemical binding]; other site
633149000075	Switch I region; other site
633149000076	G2 box; other site
633149000077	G3 box; other site
633149000078	Switch II region; other site
633149000079	G4 box; other site
633149000080	G5 box; other site
633149000081	BipA_TypA_II: domain II of BipA (also called TypA) having homology to domain II of the elongation factors (EFs) EF-G and EF-Tu.  BipA is a highly conserved protein with global regulatory properties in Escherichia coli. BipA is phosphorylated on a...; Region: BipA_TypA_II; cd03691
633149000082	BipA_TypA_C: a C-terminal portion of BipA or TypA having homology to the C terminal domains of the elongation factors EF-G and EF-2. A member of the ribosome binding GTPase superfamily, BipA is widely distributed in bacteria and plants.  BipA is a highly...; Region: BipA_TypA_C; cd03710
633149000083	CbiD; Region: CbiD; cl00828
633149000084	molybdopterin biosynthesis protein MoeB; Provisional; Region: PRK05690
633149000085	ThiF_MoeB_HesA. Family of E1-like enzymes involved in molybdopterin and thiamine biosynthesis family. The common reaction mechanism catalyzed by MoeB and ThiF, like other E1 enzymes, begins with a nucleophilic attack of the C-terminal carboxylate of MoaD...; Region: ThiF_MoeB_HesA_family; cd00757
633149000086	ATP binding site [chemical binding]; other site
633149000087	substrate interface [chemical binding]; other site
633149000088	Sensors of blue-light using FAD; Region: BLUF; pfam04940
633149000089	Protease HslV and the ATPase/chaperone HslU are part of an ATP-dependent proteolytic system that is the prokaryotic homolog of the proteasome. HslV is a dimer of hexamers (a dodecamer) that forms a central proteolytic chamber with active sites on the...; Region: protease_HslV; cd01913
633149000090	active site
633149000091	HslU subunit interaction site [polypeptide binding]; other site
633149000092	ATP-dependent protease ATP-binding subunit HslU; Provisional; Region: hslU; PRK05201
633149000093	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
633149000094	Walker A motif; other site
633149000095	ATP binding site [chemical binding]; other site
633149000096	AAA domain (Cdc48 subfamily); Region: AAA_2; pfam07724
633149000097	C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086
633149000098	Predicted Fe-S-cluster redox enzyme [General function prediction only]; Region: COG0820
633149000099	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
633149000100	FeS/SAM binding site; other site
633149000101	Ornithine acetyltransferase (OAT) family; also referred to as ArgJ. OAT catalyzes the first and fifth steps in arginine biosynthesis, coupling acetylation of glutamate with deacetylation of N-acetylornithine, which allows recycling of the acetyl group in...; Region: OAT; cd02152
633149000102	heterotetramer interface [polypeptide binding]; other site
633149000103	active site pocket [active]
633149000104	cleavage site
633149000105	peptidylprolyl isomerase; Provisional; Region: prsA; PRK00059
633149000106	PPIC-type PPIASE domain; Region: Rotamase; pfam00639
633149000107	preprotein translocase subunit SecA; Reviewed; Region: PRK12904
633149000108	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
633149000109	ATP binding site [chemical binding]; other site
633149000110	putative Mg++ binding site [ion binding]; other site
633149000111	SecA preprotein cross-linking domain; Region: SecA_PP_bind; smart00958
633149000112	SEC-C motif; Region: SEC-C; pfam02810
633149000113	Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520
633149000114	Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321
633149000115	Globin domain present in Globin-Coupled-Sensors (GCS). These domains detect changes in intracellular concentrations of oxygen, carbon monoxyde, or nitrous oxide,  which result in aerotaxis and/or gene regulation. One subgroup, the HemATs, are aerotactic...; Region: sensor_globin; cd01068
633149000116	heme-binding site [chemical binding]; other site
633149000117	Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283
633149000118	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
633149000119	dimer interface [polypeptide binding]; other site
633149000120	putative CheW interface [polypeptide binding]; other site
633149000121	Methylmalonate semialdehyde dehydrogenase and ALDH family members 6A1 and 6B2; Region: ALDH_F6_MMSDH; cd07085
633149000122	methylmalonic acid semialdehyde dehydrogenase; Region: MMSDH; TIGR01722
633149000123	tetrameric interface [polypeptide binding]; other site
633149000124	NAD binding site [chemical binding]; other site
633149000125	catalytic residues [active]
633149000126	Cobalamin adenosyltransferase; Region: Cob_adeno_trans; pfam01923
633149000127	Hypoxia induced protein conserved region; Region: HIG_1_N; pfam04588
633149000128	S-adenosyl-L-homocysteine hydrolase; Provisional; Region: PRK05476
633149000129	S-Adenosylhomocysteine Hydrolase, NAD-binding and catalytic domains; Region: SAHH; cd00401
633149000130	homotetramer interface [polypeptide binding]; other site
633149000131	ligand binding site [chemical binding]; other site
633149000132	catalytic site [active]
633149000133	NAD binding site [chemical binding]; other site
633149000134	biotin synthase; Region: bioB; TIGR00433
633149000135	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
633149000136	FeS/SAM binding site; other site
633149000137	Biotin and Thiamin Synthesis associated domain; Region: BATS; smart00876
633149000138	Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739
633149000139	Peptidase family M23; Region: Peptidase_M23; pfam01551
633149000140	Dicarboxylate transport; Region: DctA-YdbH; cl14674
633149000141	YnbE-like lipoprotein; Region: Lipoprotein_19; pfam13617
633149000142	Protein of unknown function (DUF1318); Region: DUF1318; cl01547
633149000143	transaldolase/EF-hand domain-containing protein; Provisional; Region: PRK12309
633149000144	2-polyprenylphenol 6-hydroxylase; Region: UbiB; TIGR01982
633149000145	ABC1 family; Region: ABC1; cl17513
633149000146	Methylase involved in ubiquinone/menaquinone biosynthesis [Coenzyme metabolism]; Region: UbiE; COG2226
633149000147	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
633149000148	S-adenosylmethionine binding site [chemical binding]; other site
633149000149	cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664
633149000150	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
633149000151	ligand binding site [chemical binding]; other site
633149000152	flexible hinge region; other site
633149000153	helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092
633149000154	putative switch regulator; other site
633149000155	non-specific DNA interactions [nucleotide binding]; other site
633149000156	DNA binding site [nucleotide binding]
633149000157	sequence specific DNA binding site [nucleotide binding]; other site
633149000158	putative cAMP binding site [chemical binding]; other site
633149000159	PCD_DCoH: The bifunctional protein pterin-4alpha-carbinolamine dehydratase (PCD), also known as DCoH  (dimerization cofactor of hepatocyte nuclear factor-1), is both a transcription activator and a metabolic enzyme.  DCoH stimulates gene expression by...; Region: PCD_DCoH_subfamily_b; cd00914
633149000160	aromatic arch; other site
633149000161	DCoH dimer interaction site [polypeptide binding]; other site
633149000162	DCoH /HNF-1 dimer interaction site [polypeptide binding]; other site
633149000163	DCoH tetramer interaction site [polypeptide binding]; other site
633149000164	substrate binding site [chemical binding]; other site
633149000165	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
633149000166	short chain dehydrogenase; Validated; Region: PRK07069
633149000167	NAD(P) binding site [chemical binding]; other site
633149000168	active site
633149000169	Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471
633149000170	lysozyme_like domain.  This contains several members including Soluble Lytic Transglycosylases (SLT), Goose Egg-White Lysozymes (GEWL), Hen Egg-White Lysozymes (HEWL), chitinases, bacteriophage lambda lysozymes, endolysins, autolysins, and chitosanases; Region: lysozyme_like; cl00222
633149000171	catalytic residue [active]
633149000172	Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321
633149000173	Protein of unknown function (DUF1353); Region: DUF1353; pfam07087
633149000174	Domain of unknown function (DUF4376); Region: DUF4376; pfam14301
633149000175	Putative phage tail protein; Region: Phage-tail_3; pfam13550
633149000176	Uncharacterized conserved protein (DUF2190); Region: DUF2190; pfam09956
633149000177	Caudovirus prohead protease; Region: Peptidase_U35; cl01521
633149000178	phage portal protein, lambda family; Region: portal_lambda; TIGR01539
633149000179	Phage portal protein, lambda family; Region: Phage_portal_2; pfam05136
633149000180	Phage terminase large subunit (GpA); Region: Terminase_GpA; pfam05876
633149000181	UvrD/REP helicase N-terminal domain; Region: UvrD-helicase; pfam00580
633149000182	CHC2 zinc finger; Region: zf-CHC2; cl17510
633149000183	ParB-like nuclease domain; Region: ParBc; cl02129
633149000184	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
633149000185	non-specific DNA binding site [nucleotide binding]; other site
633149000186	salt bridge; other site
633149000187	sequence-specific DNA binding site [nucleotide binding]; other site
633149000188	SOS-response transcriptional repressors (RecA-mediated autopeptidases) [Transcription / Signal transduction mechanisms]; Region: LexA; COG1974
633149000189	ParB-like nuclease domain; Region: ParB; smart00470
633149000190	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
633149000191	DNA binding site [nucleotide binding]
633149000192	active site
633149000193	Int/Topo IB signature motif; other site
633149000194	TIGR04255 family protein; Region: sporadTIGR04255
633149000195	Molybdopterin biosynthesis enzyme [Coenzyme metabolism]; Region: MoeA; COG0303
633149000196	MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoeA; cd00887
633149000197	dimer interface [polypeptide binding]; other site
633149000198	putative functional site; other site
633149000199	putative MPT binding site; other site
633149000200	molybdenum cofactor biosynthesis protein MoaC; Provisional; Region: moaC; PRK09364
633149000201	trimer interface [polypeptide binding]; other site
633149000202	dimer interface [polypeptide binding]; other site
633149000203	putative active site [active]
633149000204	MogA_MoaB family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF) an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea; Region: MogA_MoaB; cd00886
633149000205	MPT binding site; other site
633149000206	trimer interface [polypeptide binding]; other site
633149000207	MoaE family. Members of this family are involved in biosynthesis of the molybdenum cofactor (Moco), an essential cofactor for a diverse group of redox enzymes. Moco biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoaE; cd00756
633149000208	MoaE homodimer interface [polypeptide binding]; other site
633149000209	MoaD interaction [polypeptide binding]; other site
633149000210	active site residues [active]
633149000211	Ubiquitin domain of MoaD-like proteins; Region: MoaD; cd00754
633149000212	MoaE interaction surface [polypeptide binding]; other site
633149000213	MoeB interaction surface [polypeptide binding]; other site
633149000214	thiocarboxylated glycine; other site
633149000215	molybdenum cofactor biosynthesis protein A; Reviewed; Region: moaA; PRK00164
633149000216	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
633149000217	FeS/SAM binding site; other site
633149000218	Molybdenum Cofactor Synthesis C; Region: Mob_synth_C; pfam06463
633149000219	ABC-type molybdate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: ModA; COG0725
633149000220	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199
633149000221	N-terminal domain of molybdenum-binding protein [General function prediction only]; Region: ModE; cl17549
633149000222	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
633149000223	dimer interface [polypeptide binding]; other site
633149000224	conserved gate region; other site
633149000225	ABC-ATPase subunit interface; other site
633149000226	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
633149000227	thiamine ABC transporter, ATP-binding protein; Region: thiQ; TIGR01277
633149000228	Walker A/P-loop; other site
633149000229	ATP binding site [chemical binding]; other site
633149000230	Q-loop/lid; other site
633149000231	ABC transporter signature motif; other site
633149000232	Walker B; other site
633149000233	D-loop; other site
633149000234	H-loop/switch region; other site
633149000235	Thiosulfate reductase cytochrome B subunit (membrane anchoring protein) [Energy production and conversion]; Region: COG4117
633149000236	Cytochrome b (N-terminus)/b6/petB:  Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria; Region: Cytochrome_b_N; cl00859
633149000237	bacterial subgroup of the sulfite oxidase (SO) family of molybdopterin binding domains. This domain is found in a variety of oxidoreductases. Common features of all known members of this family, like sulfite oxidase and nitrite reductase, are that they...; Region: bact_SO_family_Moco; cd02108
633149000238	Sulfite oxidase and related enzymes [General function prediction only]; Region: COG2041
633149000239	Moco binding site; other site
633149000240	metal coordination site [ion binding]; other site
633149000241	putative oxidoreductase; Provisional; Region: PRK11579
633149000242	Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408
633149000243	Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894
633149000244	Ribonucleotide Reductase, R2/beta subunit, ferritin-like diiron-binding domain; Region: RNRR2; cd01049
633149000245	dimer interface [polypeptide binding]; other site
633149000246	putative radical transfer pathway; other site
633149000247	diiron center [ion binding]; other site
633149000248	tyrosyl radical; other site
633149000249	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
633149000250	dimer interface [polypeptide binding]; other site
633149000251	phosphorylation site [posttranslational modification]
633149000252	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
633149000253	ATP binding site [chemical binding]; other site
633149000254	Mg2+ binding site [ion binding]; other site
633149000255	G-X-G motif; other site
633149000256	FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784
633149000257	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
633149000258	active site
633149000259	phosphorylation site [posttranslational modification]
633149000260	intermolecular recognition site; other site
633149000261	dimerization interface [polypeptide binding]; other site
633149000262	Protein of unknown function (DUF3423); Region: DUF3423; pfam11903
633149000263	metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995
633149000264	Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149
633149000265	active site
633149000266	metal binding site [ion binding]; metal-binding site
633149000267	F0F1 ATP synthase subunit delta; Validated; Region: PRK05758
633149000268	ATP synthase delta (OSCP) subunit; Region: OSCP; pfam00213
633149000269	F0F1 ATP synthase subunit alpha; Validated; Region: PRK09281
633149000270	ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874
633149000271	F1 ATP synthase alpha, central domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a proton gradient to...; Region: F1_ATPase_alpha; cd01132
633149000272	beta subunit interaction interface [polypeptide binding]; other site
633149000273	Walker A motif; other site
633149000274	ATP binding site [chemical binding]; other site
633149000275	Walker B motif; other site
633149000276	ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306
633149000277	mitochondrial ATP synthase gamma subunit; Region: F1-ATPase_gamma; cd12151
633149000278	core domain interface [polypeptide binding]; other site
633149000279	delta subunit interface [polypeptide binding]; other site
633149000280	epsilon subunit interface [polypeptide binding]; other site
633149000281	F0F1 ATP synthase subunit beta; Validated; Region: PRK09280
633149000282	ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874
633149000283	F1 ATP synthase beta subunit, nucleotide-binding domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a...; Region: F1-ATPase_beta; cd01133
633149000284	alpha subunit interaction interface [polypeptide binding]; other site
633149000285	Walker A motif; other site
633149000286	ATP binding site [chemical binding]; other site
633149000287	Walker B motif; other site
633149000288	inhibitor binding site; inhibition site
633149000289	ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306
633149000290	mitochondrial ATP synthase delta subunit; Region: F1-ATPase_delta; cd12152
633149000291	gamma subunit interface [polypeptide binding]; other site
633149000292	LBP interface [polypeptide binding]; other site
633149000293	metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995
633149000294	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3813
633149000295	Protein of unknown function (DUF1272); Region: DUF1272; pfam06906
633149000296	Diadenosine tetraphosphate (Ap4A) hydrolase is a member of the Nudix hydrolase superfamily. Members of this family are well represented in a variety of prokaryotic and eukaryotic organisms. Phylogenetic analysis reveals two distinct subgroups where plant...; Region: Ap4A_hydrolase_plant_like; cd03671
633149000297	putative active site [active]
633149000298	Ap4A binding site [chemical binding]; other site
633149000299	nudix motif; other site
633149000300	putative metal binding site [ion binding]; other site
633149000301	Putative catalytic domain of family 2 polysaccharide deacetylases (DACs) from bacteria; Region: CE4_DAC2; cd10936
633149000302	NodB motif; other site
633149000303	putative active site [active]
633149000304	putative catalytic site [active]
633149000305	Zn binding site [ion binding]; other site
633149000306	C-terminal processing peptidase family S41; Region: Peptidase_S41; cl02526
633149000307	C-terminal peptidase (prc); Region: prc; TIGR00225
633149000308	PDZ domain of C-terminal processing-, tail-specific-, and tricorn proteases, which function in posttranslational protein processing, maturation, and disassembly or degradation, in Bacteria, Archaea, and plant chloroplasts. May be responsible for...; Region: PDZ_CTP_protease; cd00988
633149000309	protein binding site [polypeptide binding]; other site
633149000310	C-terminal processing peptidase; serine protease family S41; Region: Peptidase_S41_CPP; cd07560
633149000311	Catalytic dyad [active]
633149000312	Membrane-bound metallopeptidase [Cell division and chromosome partitioning]; Region: COG4942
633149000313	Peptidase family M23; Region: Peptidase_M23; pfam01551
633149000314	rRNA large subunit methyltransferase; Provisional; Region: PRK00103
633149000315	iojap-like ribosome-associated protein; Region: iojap_ybeB; TIGR00090
633149000316	Nicotinamide/nicotinate mononucleotide adenylyltransferase; Region: NMNAT; cd02165
633149000317	Cytidylyltransferase; Region: CTP_transf_2; pfam01467
633149000318	active site
633149000319	(T/H)XGH motif; other site
633149000320	GTPase CgtA; Reviewed; Region: obgE; PRK12299
633149000321	GTP1/OBG; Region: GTP1_OBG; pfam01018
633149000322	Obg GTPase; Region: Obg; cd01898
633149000323	G1 box; other site
633149000324	GTP/Mg2+ binding site [chemical binding]; other site
633149000325	Switch I region; other site
633149000326	G2 box; other site
633149000327	G3 box; other site
633149000328	Switch II region; other site
633149000329	G4 box; other site
633149000330	G5 box; other site
633149000331	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
633149000332	active site
633149000333	Imidazolonepropionase and related amidohydrolases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: HutI; COG1228
633149000334	Metallo-dependent hydrolases, subgroup C is part of the superfamily of metallo-dependent hydrolases, a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the...; Region: Met_dep_hydrolase_C; cd01309
633149000335	active site
633149000336	Uncharacterized ACR, YggU family COG1872; Region: DUF167; cl00811
633149000337	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
633149000338	dimerization interface [polypeptide binding]; other site
633149000339	putative DNA binding site [nucleotide binding]; other site
633149000340	putative Zn2+ binding site [ion binding]; other site
633149000341	Electron transfer flavoprotein, alpha subunit [Energy production and conversion]; Region: FixB; COG2025
633149000342	The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_alpha; cd01715
633149000343	Electron transfer flavoprotein FAD-binding domain; Region: ETF_alpha; pfam00766
633149000344	The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_beta; cd01714
633149000345	Ligand binding site [chemical binding]; other site
633149000346	Electron transfer flavoprotein domain; Region: ETF; pfam01012
633149000347	Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596
633149000348	PGAP1-like protein; Region: PGAP1; pfam07819
633149000349	Novel bacterial esterase that cleaves esters on halogenated cyclic compounds; Region: Esterase_713_like; cl17303
633149000350	Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153
633149000351	metal binding site 2 [ion binding]; metal-binding site
633149000352	putative DNA binding helix; other site
633149000353	metal binding site 1 [ion binding]; metal-binding site
633149000354	dimer interface [polypeptide binding]; other site
633149000355	structural Zn2+ binding site [ion binding]; other site
633149000356	TonB-dependent heme/hemoglobin receptor family protein; Region: TonB-hemin; TIGR01785
633149000357	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
633149000358	N-terminal plug; other site
633149000359	ligand-binding site [chemical binding]; other site
633149000360	SapC; Region: SapC; pfam07277
633149000361	The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509
633149000362	active site 2 [active]
633149000363	active site 1 [active]
633149000364	Prostaglandin dehydrogenases; Region: PGDH; cd05288
633149000365	Putative NADP-dependent oxidoreductases [General function prediction only]; Region: COG2130
633149000366	NAD(P) binding site [chemical binding]; other site
633149000367	substrate binding site [chemical binding]; other site
633149000368	dimer interface [polypeptide binding]; other site
633149000369	two-component response regulator; Provisional; Region: PRK09191
633149000370	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
633149000371	active site
633149000372	phosphorylation site [posttranslational modification]
633149000373	intermolecular recognition site; other site
633149000374	dimerization interface [polypeptide binding]; other site
633149000375	RNA polymerase sigma factor; Provisional; Region: PRK12547
633149000376	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
633149000377	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
633149000378	DNA binding residues [nucleotide binding]
633149000379	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920
633149000380	Histidine kinase; Region: HisKA_2; pfam07568
633149000381	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
633149000382	ATP binding site [chemical binding]; other site
633149000383	Mg2+ binding site [ion binding]; other site
633149000384	G-X-G motif; other site
633149000385	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
633149000386	putative substrate translocation pore; other site
633149000387	succinic semialdehyde dehydrogenase; Region: PLN02278
633149000388	Mitochondrial succinate-semialdehyde dehydrogenase and ALDH family members 5A1 and 5F1-like; Region: ALDH_F5_SSADH_GabD; cd07103
633149000389	tetramerization interface [polypeptide binding]; other site
633149000390	NAD(P) binding site [chemical binding]; other site
633149000391	catalytic residues [active]
633149000392	Transcriptional regulators [Transcription]; Region: Lrp; COG1522
633149000393	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
633149000394	putative DNA binding site [nucleotide binding]; other site
633149000395	putative Zn2+ binding site [ion binding]; other site
633149000396	AsnC family; Region: AsnC_trans_reg; pfam01037
633149000397	Alanine dehydrogenase [Amino acid transport and metabolism]; Region: Ald; COG0686
633149000398	Alanine dehydrogenase NAD-binding and catalytic domains; Region: L-AlaDH; cd05305
633149000399	hexamer interface [polypeptide binding]; other site
633149000400	ligand binding site [chemical binding]; other site
633149000401	putative active site [active]
633149000402	NAD(P) binding site [chemical binding]; other site
633149000403	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1671
633149000404	Protein chain release factor B [Translation, ribosomal structure and biogenesis]; Region: PrfB; COG1186
633149000405	hypothetical protein; Provisional; Region: PRK09256
633149000406	Site-specific DNA methylase [DNA replication, recombination, and repair]; Region: Dcm; COG0270
633149000407	Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group...; Region: Cyt_C5_DNA_methylase; cd00315
633149000408	cofactor binding site; other site
633149000409	DNA binding site [nucleotide binding]
633149000410	substrate interaction site [chemical binding]; other site
633149000411	Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group...; Region: Cyt_C5_DNA_methylase; cd00315
633149000412	Predicted membrane protein [Function unknown]; Region: COG3650
633149000413	Predicted acyltransferases [Lipid metabolism]; Region: COG1835
633149000414	CHAP domain; Region: CHAP; cl17642
633149000415	Surface antigen [General function prediction only]; Region: COG3942
633149000416	Mg2+ and Co2+ transporters [Inorganic ion transport and metabolism]; Region: CorA; COG0598
633149000417	uncharacterized subgroup of the Escherichia coli Mg2+ transporter CorA_like subfamily; Region: EcCorA-like_u1; cd12837
633149000418	Cl binding site [ion binding]; other site
633149000419	oligomer interface [polypeptide binding]; other site
633149000420	Uncharacterized protein conserved in bacteria (DUF2219); Region: DUF2219; cl01409
633149000421	ribonucleotide-diphosphate reductase subunit alpha; Validated; Region: PRK09102
633149000422	Class I ribonucleotide reductase; Region: RNR_I; cd01679
633149000423	active site
633149000424	dimer interface [polypeptide binding]; other site
633149000425	catalytic residues [active]
633149000426	effector binding site; other site
633149000427	R2 peptide binding site; other site
633149000428	PAP2_like_2 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which is specific to bacteria, lacks functional characterization and may act as a membrane-associated lipid phosphatase; Region: PAP2_like_2; cd03392
633149000429	active site
633149000430	Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671
633149000431	Predicted membrane protein [Function unknown]; Region: COG2119
633149000432	Uncharacterized protein family UPF0016; Region: UPF0016; pfam01169
633149000433	Membrane protein TerC, possibly involved in tellurium resistance [Inorganic ion transport and metabolism]; Region: TerC; COG0861
633149000434	Glutamine cyclotransferase [Posttranslational modification, protein turnover, chaperones]; Region: COG3823
633149000435	Ku-homolog [Replication, recombination, and repair]; Region: COG1273
633149000436	Ku-core domain, Ku-like subfamily; composed of prokaryotic homologs of the eukaryotic DNA binding protein Ku. The alignment includes the core domain shared by the prokaryotic YkoV-like proteins and the eukaryotic Ku70 and Ku80. The prokaryotic Ku...; Region: KU_like; cd00789
633149000437	putative DNA binding site [nucleotide binding]; other site
633149000438	putative homodimer interface [polypeptide binding]; other site
633149000439	chaperonin GroEL; Reviewed; Region: groEL; PRK12849
633149000440	GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344
633149000441	ring oligomerisation interface [polypeptide binding]; other site
633149000442	ATP/Mg binding site [chemical binding]; other site
633149000443	stacking interactions; other site
633149000444	hinge regions; other site
633149000445	Chaperonin 10 Kd subunit (cpn10 or GroES); Cpn10 cooperates with chaperonin 60 (cpn60 or GroEL), an ATPase, to assist the folding and assembly of proteins and is found in eubacterial cytosol, as well as in the matrix of mitochondria and chloroplasts. It...; Region: cpn10; cd00320
633149000446	oligomerisation interface [polypeptide binding]; other site
633149000447	mobile loop; other site
633149000448	roof hairpin; other site
633149000449	glucose-6-phosphate isomerase; Reviewed; Region: pgi; PRK00179
633149000450	Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the first SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_1; cd05015
633149000451	active site
633149000452	dimer interface [polypeptide binding]; other site
633149000453	Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the second SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_2; cd05016
633149000454	dimer interface [polypeptide binding]; other site
633149000455	active site
633149000456	Disulphide bond corrector protein DsbC; Region: DsbC; cl15830
633149000457	Thiol:disulfide interchange protein [Posttranslational modification, protein turnover, chaperones / Energy production and conversion]; Region: COG4232
633149000458	DsbD gamma family; DsbD gamma is the C-terminal periplasmic domain of the bacterial protein DsbD. It contains a CXXC motif in a TRX fold and shuttles the reducing potential from the membrane domain (DsbD beta) to the N-terminal periplasmic domain (DsbD...; Region: DsbDgamma; cd02953
633149000459	DsbD alpha interface [polypeptide binding]; other site
633149000460	catalytic residues [active]
633149000461	Flp pilus assembly protein, pilin Flp [Intracellular trafficking and secretion]; Region: Flp; COG3847
633149000462	The MutT pyrophosphohydrolase is a prototypical Nudix hydrolase that catalyzes the hydrolysis of nucleoside and deoxynucleoside triphosphates (NTPs and dNTPs) by substitution at a beta-phosphorus to yield a nucleotide monophosphate (NMP) and inorganic...; Region: MutT_pyrophosphohydrolase; cd03425
633149000463	active site
633149000464	8-oxo-dGMP binding site [chemical binding]; other site
633149000465	nudix motif; other site
633149000466	metal binding site [ion binding]; metal-binding site
633149000467	Predicted membrane protein [Function unknown]; Region: COG3766
633149000468	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]; Region: DegQ; COG0265
633149000469	Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365
633149000470	Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280
633149000471	This CD includes bacterial (Agrobacterium tumefaciens and Caulobacter crescentus ProX, and Clostridium sticklandii PrdX) and eukaryotic (Plasmodium falciparum N-terminal ProRS editing domain) sequences. The C. sticklandii PrdX protein, a homolog of the...; Region: PrdX_deacylase; cd04335
633149000472	putative deacylase active site [active]
633149000473	Thioredoxin domain-containing protein [Posttranslational modification, protein turnover, chaperones]; Region: COG3118
633149000474	TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947
633149000475	catalytic residues [active]
633149000476	Uncharacterized protein, similar to the N-terminal domain of Lon protease [General function prediction only]; Region: COG2802
633149000477	Uncharacterized conserved protein [Function unknown]; Region: COG2835
633149000478	2OG-Fe(II) oxygenase superfamily; Region: 2OG-FeII_Oxy_2; pfam13532
633149000479	Dienelactone hydrolase and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG0412
633149000480	heat shock protein GrpE; Provisional; Region: PRK14141
633149000481	GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70)-type ATPases. The GrpE dimer binds to the ATPase domain of Hsp70 catalyzing the dissociation of ADP, which enables rebinding of ATP, one step in the Hsp70 reaction cycle in protein folding; Region: GrpE; cd00446
633149000482	dimer interface [polypeptide binding]; other site
633149000483	hsp70 (ATPase domain) interactions [polypeptide binding]; other site
633149000484	heat-inducible transcription repressor; Provisional; Region: hrcA; PRK00082
633149000485	ribonuclease PH; Reviewed; Region: rph; PRK00173
633149000486	Ribonuclease PH; Region: RNase_PH_bact; cd11362
633149000487	hexamer interface [polypeptide binding]; other site
633149000488	active site
633149000489	polynucleotide phosphorylase/polyadenylase; Provisional; Region: PRK11824
633149000490	Polyribonucleotide nucleotidyltransferase, repeat 1; Region: RNase_PH_PNPase_1; cd11363
633149000491	RNase E interface [polypeptide binding]; other site
633149000492	trimer interface [polypeptide binding]; other site
633149000493	Polyribonucleotide nucleotidyltransferase, RNA binding domain; Region: PNPase; pfam03726
633149000494	Polyribonucleotide nucleotidyltransferase, repeat 2; Region: RNase_PH_PNPase_2; cd11364
633149000495	RNase E interface [polypeptide binding]; other site
633149000496	trimer interface [polypeptide binding]; other site
633149000497	active site
633149000498	Polynucleotide phosphorylase (PNPase) K homology RNA-binding domain (KH). PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA in prokaryotes and plant chloroplasts. The C-terminal region of PNPase contains domains homologous to...; Region: PNPase_KH; cd02393
633149000499	putative nucleic acid binding region [nucleotide binding]; other site
633149000500	G-X-X-G motif; other site
633149000501	S1_PNPase: Polynucleotide phosphorylase (PNPase), ), S1-like RNA-binding domain. PNPase  is a polyribonucleotide nucleotidyl transferase that degrades mRNA. It is a trimeric multidomain protein. The C-terminus contains the S1 domain which binds ssRNA; Region: S1_PNPase; cd04472
633149000502	RNA binding site [nucleotide binding]; other site
633149000503	domain interface; other site
633149000504	Ribosomal protein S15 (prokaryotic)_S13 (eukaryotic) binds the central domain of 16S rRNA and is required for assembly of the small ribosomal subunit and for intersubunit association, thus representing a key element in the assembly of the whole ribosome; Region: Ribosomal_S15p_S13e; cd00353
633149000505	16S/18S rRNA binding site [nucleotide binding]; other site
633149000506	S13e-L30e interaction site [polypeptide binding]; other site
633149000507	25S rRNA binding site [nucleotide binding]; other site
633149000508	tRNA pseudouridine synthase B; Provisional; Region: truB; PRK05389
633149000509	Pseudouridine synthase, Escherichia coli TruB like; Region: PseudoU_synth_EcTruB; cd02573
633149000510	RNA binding site [nucleotide binding]; other site
633149000511	active site
633149000512	ribosome-binding factor A; Validated; Region: rbfA; PRK00521
633149000513	Protein of unknown function (DUF2459); Region: DUF2459; cl09819
633149000514	translation initiation factor IF-2; Region: IF-2; TIGR00487
633149000515	Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760
633149000516	Initiation Factor 2 (IF2)/ eukaryotic Initiation Factor 5B (eIF5B) family; Region: IF2_eIF5B; cd01887
633149000517	G1 box; other site
633149000518	putative GEF interaction site [polypeptide binding]; other site
633149000519	GTP/Mg2+ binding site [chemical binding]; other site
633149000520	Switch I region; other site
633149000521	G2 box; other site
633149000522	G3 box; other site
633149000523	Switch II region; other site
633149000524	G4 box; other site
633149000525	G5 box; other site
633149000526	This family represents the domain II of bacterial Initiation Factor 2 (IF2) and its eukaryotic mitochondrial homologue mtIF2. IF2, the largest initiation factor is an essential GTP binding protein. In E. coli three natural forms of IF2 exist in the cell; Region: IF2_mtIF2_II; cd03702
633149000527	Translation-initiation factor 2; Region: IF-2; pfam11987
633149000528	mtIF2_IVc: this family represents the C2 subdomain of domain IV of mitochondrial translation initiation factor 2 (mtIF2) which adopts a beta-barrel fold displaying a high degree of structural similarity with domain II of the translation elongation factor...; Region: mtIF2_IVc; cd03692
633149000529	hypothetical protein; Provisional; Region: PRK09190
633149000530	Ylxr homologs; group of conserved hypothetical bacterial proteins of unknown function; structure revealed putative RNA binding cleft; proteins are encoded by an operon that includes other proteins involved in transcription and/or translation; Region: YlxR; cd00279
633149000531	putative RNA binding cleft [nucleotide binding]; other site
633149000532	Ribosomal protein L7Ae/L30e/S12e/Gadd45 family; Region: Ribosomal_L7Ae; cl00600
633149000533	transcription elongation factor NusA; Validated; Region: nusA; PRK09202
633149000534	NusA N-terminal domain; Region: NusA_N; pfam08529
633149000535	S1_NusA: N-utilizing substance A protein (NusA), S1-like RNA-binding domain. S1-like RNA-binding domains are found in a wide variety of RNA-associated proteins. NusA is a transcription elongation factor containing an N-terminal catalytic domain and three...; Region: S1_NusA; cd04455
633149000536	RNA binding site [nucleotide binding]; other site
633149000537	homodimer interface [polypeptide binding]; other site
633149000538	NusA-like KH domain; Region: KH_5; pfam13184
633149000539	NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134
633149000540	G-X-X-G motif; other site
633149000541	transcription termination factor NusA, C-terminal duplication; Region: nusA_Cterm_rpt; TIGR01954
633149000542	ribosome maturation protein RimP; Reviewed; Region: PRK00092
633149000543	Sm and related proteins; Region: Sm_like; cl00259
633149000544	Bacillus subtilis YxlS-like, C-terminal domain; Region: YlxS_C; cd01734
633149000545	putative oligomer interface [polypeptide binding]; other site
633149000546	putative RNA binding site [nucleotide binding]; other site
633149000547	Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557
633149000548	trimer interface [polypeptide binding]; other site
633149000549	active site
633149000550	bifunctional phosphopantothenoylcysteine decarboxylase/phosphopantothenate synthase; Validated; Region: PRK05579
633149000551	Flavoprotein; Region: Flavoprotein; pfam02441
633149000552	DNA / pantothenate metabolism flavoprotein; Region: DFP; pfam04127
633149000553	Pyocin large subunit [General function prediction only]; Region: COG5529
633149000554	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
633149000555	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
633149000556	non-specific DNA binding site [nucleotide binding]; other site
633149000557	salt bridge; other site
633149000558	sequence-specific DNA binding site [nucleotide binding]; other site
633149000559	Protein of unknown function (DUF989); Region: DUF989; pfam06181
633149000560	apolipoprotein N-acyltransferase; Region: lnt; TIGR00546
633149000561	Apolipoprotein N-acyl transferase (class 9 nitrilases); Region: ALP_N-acyl_transferase; cd07571
633149000562	putative active site [active]
633149000563	catalytic triad [active]
633149000564	putative dimer interface [polypeptide binding]; other site
633149000565	Uncharacterized protein family UPF0054; Region: UPF0054; cl00402
633149000566	Phosphate starvation-inducible protein PhoH, predicted ATPase [Signal transduction mechanisms]; Region: PhoH; COG1702
633149000567	PhoH-like protein; Region: PhoH; pfam02562
633149000568	(dimethylallyl)adenosine tRNA methylthiotransferase; Provisional; Region: PRK14325
633149000569	Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919
633149000570	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
633149000571	FeS/SAM binding site; other site
633149000572	TRAM domain; Region: TRAM; pfam01938
633149000573	Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153
633149000574	metal binding site 2 [ion binding]; metal-binding site
633149000575	putative DNA binding helix; other site
633149000576	metal binding site 1 [ion binding]; metal-binding site
633149000577	dimer interface [polypeptide binding]; other site
633149000578	structural Zn2+ binding site [ion binding]; other site
633149000579	Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583
633149000580	tRNA threonylcarbamoyl adenosine modification protein YeaZ; Region: T6A_YeaZ; TIGR03725
633149000581	Glycoprotease family; Region: Peptidase_M22; pfam00814
633149000582	Response regulator receiver domain; Region: Response_reg; pfam00072
633149000583	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
633149000584	active site
633149000585	phosphorylation site [posttranslational modification]
633149000586	intermolecular recognition site; other site
633149000587	dimerization interface [polypeptide binding]; other site
633149000588	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
633149000589	dimer interface [polypeptide binding]; other site
633149000590	phosphorylation site [posttranslational modification]
633149000591	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
633149000592	ATP binding site [chemical binding]; other site
633149000593	Mg2+ binding site [ion binding]; other site
633149000594	G-X-G motif; other site
633149000595	Response regulator receiver domain; Region: Response_reg; pfam00072
633149000596	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
633149000597	active site
633149000598	phosphorylation site [posttranslational modification]
633149000599	intermolecular recognition site; other site
633149000600	dimerization interface [polypeptide binding]; other site
633149000601	Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088
633149000602	putative binding surface; other site
633149000603	active site
633149000604	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
633149000605	Response regulator receiver domain; Region: Response_reg; pfam00072
633149000606	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
633149000607	active site
633149000608	phosphorylation site [posttranslational modification]
633149000609	intermolecular recognition site; other site
633149000610	dimerization interface [polypeptide binding]; other site
633149000611	Flp pilus assembly protein TadG [Intracellular trafficking and secretion]; Region: TadG; COG4961
633149000612	ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131
633149000613	ATP-binding cassette domain of the lipid transporters, subfamily A; Region: ABC_subfamily_A; cd03263
633149000614	Walker A/P-loop; other site
633149000615	ATP binding site [chemical binding]; other site
633149000616	Q-loop/lid; other site
633149000617	ABC transporter signature motif; other site
633149000618	Walker B; other site
633149000619	D-loop; other site
633149000620	H-loop/switch region; other site
633149000621	Zinc-finger domain; Region: zf-CHCC; pfam10276
633149000622	Predicted flavoprotein [General function prediction only]; Region: COG0431
633149000623	NADPH-dependent FMN reductase; Region: FMN_red; pfam03358
633149000624	Predicted flavoproteins [General function prediction only]; Region: COG2081
633149000625	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
633149000626	Uncharacterized conserved protein [Function unknown]; Region: COG5323
633149000627	Terminase-like family; Region: Terminase_6; pfam03237
633149000628	Uncharacterized ACR, COG2135; Region: DUF159; cl03646
633149000629	Predicted NTPase (NACHT family) [Signal transduction mechanisms]; Region: COG5635
633149000630	DNA polymerase I; Provisional; Region: PRK05755
633149000631	PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859
633149000632	active site
633149000633	metal binding site 1 [ion binding]; metal-binding site
633149000634	putative 5' ssDNA interaction site; other site
633149000635	metal binding site 3; metal-binding site
633149000636	metal binding site 2 [ion binding]; metal-binding site
633149000637	H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898
633149000638	putative DNA binding site [nucleotide binding]; other site
633149000639	putative metal binding site [ion binding]; other site
633149000640	DEDDy 3'-5' exonuclease domain of Escherichia coli DNA polymerase I and similar bacterial family-A DNA polymerases; Region: DNA_polA_I_Ecoli_like_exo; cd06139
633149000641	active site
633149000642	catalytic site [active]
633149000643	substrate binding site [chemical binding]; other site
633149000644	Polymerase I functions primarily to fill DNA gaps that arise during DNA repair, recombination and replication; Region: DNA_pol_A_pol_I_C; cd08637
633149000645	active site
633149000646	DNA binding site [nucleotide binding]
633149000647	catalytic site [active]
633149000648	Zn-dependent alcohol dehydrogenases [General function prediction only]; Region: AdhP; COG1064
633149000649	Cinnamyl alcohol dehydrogenases (CAD); Region: CAD1; cd05283
633149000650	putative NAD(P) binding site [chemical binding]; other site
633149000651	putative substrate binding site [chemical binding]; other site
633149000652	catalytic Zn binding site [ion binding]; other site
633149000653	structural Zn binding site [ion binding]; other site
633149000654	dimer interface [polypeptide binding]; other site
633149000655	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
633149000656	Glyoxalase I catalyzes the isomerization of the hemithioacetal, formed by a 2-oxoaldehyde and glutathione, to S-D-lactoylglutathione; Region: Glyoxalase_I; cd07233
633149000657	dimer interface [polypeptide binding]; other site
633149000658	active site
633149000659	metal binding site [ion binding]; metal-binding site
633149000660	glutathione binding site [chemical binding]; other site
633149000661	Protein of unknown function (DUF1012); Region: DUF1012; pfam06241
633149000662	Transcription factor zinc-finger; Region: zf-TFIIB; cl01565
633149000663	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
633149000664	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
633149000665	active site
633149000666	phosphorylation site [posttranslational modification]
633149000667	intermolecular recognition site; other site
633149000668	dimerization interface [polypeptide binding]; other site
633149000669	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
633149000670	DNA binding site [nucleotide binding]
633149000671	Stimulus-sensing domain; Region: Stimulus_sens_1; pfam13756
633149000672	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
633149000673	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054
633149000674	dimerization interface [polypeptide binding]; other site
633149000675	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
633149000676	dimer interface [polypeptide binding]; other site
633149000677	phosphorylation site [posttranslational modification]
633149000678	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
633149000679	ATP binding site [chemical binding]; other site
633149000680	Mg2+ binding site [ion binding]; other site
633149000681	G-X-G motif; other site
633149000682	HprK/P, the bifunctional histidine-containing protein kinase/phosphatase, controls the phosphorylation state of the phosphocarrier protein HPr and regulates the utilization of carbon sources by gram-positive bacteria. It catalyzes both the ATP-dependent...; Region: HprK_C; cd01918
633149000683	Hpr binding site; other site
633149000684	active site
633149000685	homohexamer subunit interaction site [polypeptide binding]; other site
633149000686	PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cd00006
633149000687	active pocket/dimerization site; other site
633149000688	active site
633149000689	phosphorylation site [posttranslational modification]
633149000690	Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367
633149000691	regulatory protein interface [polypeptide binding]; other site
633149000692	active site
633149000693	regulatory phosphorylation site [posttranslational modification]; other site
633149000694	Predicted sulfurtransferase [General function prediction only]; Region: COG1054
633149000695	Member of the Rhodanese Homology Domain superfamily. This CD includes Escherichia coli YceA, Bacillus subtilis YbfQ, and similar uncharacterized proteins; Region: RHOD_YceA; cd01518
633149000696	active site residue [active]
633149000697	YGGT family; Region: YGGT; pfam02325
633149000698	3-hydroxybutyryl-CoA dehydrogenase; Validated; Region: PRK07530
633149000699	3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737
633149000700	3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725
633149000701	Predicted membrane protein [Function unknown]; Region: COG2311
633149000702	Protein of unknown function (DUF418); Region: DUF418; cl12135
633149000703	Protein of unknown function (DUF418); Region: DUF418; pfam04235
633149000704	Histidyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Region: HisS; COG0124
633149000705	Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for...; Region: HisRS-like_core; cd00773
633149000706	dimer interface [polypeptide binding]; other site
633149000707	motif 1; other site
633149000708	motif 2; other site
633149000709	Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA.   PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268
633149000710	motif 3; other site
633149000711	HisRS Histidyl-anticodon binding domain. HisRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: HisRS_anticodon; cd00859
633149000712	anticodon binding site; other site
633149000713	Riboflavin-specific deaminase. Riboflavin biosynthesis protein RibD (Diaminohydroxyphosphoribosylaminopyrimidine deaminase) catalyzes the deamination of 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate, which is an intermediate step in the...; Region: Riboflavin_deaminase-reductase; cd01284
633149000714	catalytic motif [active]
633149000715	Zn binding site [ion binding]; other site
633149000716	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
633149000717	catalytic core [active]
633149000718	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
633149000719	Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680
633149000720	Beta-lactamase; Region: Beta-lactamase; pfam00144
633149000721	Phosphomannomutase [Carbohydrate transport and metabolism]; Region: {ManB}; COG1109
633149000722	The phosphomannomutase/phosphoglucomutase (PMM/PGM) bifunctional enzyme catalyzes the reversible conversion of 1-phospho to 6-phospho-sugars (e.g. between mannose-1-phosphate and mannose-6-phosphate or glucose-1-phosphate and glucose-6-phosphate) via a...; Region: PMM_PGM; cd03089
633149000723	active site
633149000724	substrate binding site [chemical binding]; other site
633149000725	metal binding site [ion binding]; metal-binding site
633149000726	Glutathione-dependent formaldehyde dehydrogenase related proteins, child 1; Region: FDH_like_1; cd08283
633149000727	Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063
633149000728	NAD binding site [chemical binding]; other site
633149000729	catalytic Zn binding site [ion binding]; other site
633149000730	structural Zn binding site [ion binding]; other site
633149000731	GIY-YIG domain of uncharacterized hypothetical protein found in bacteria; Region: GIY-YIG_unchar_3; cd10448
633149000732	putative active site [active]
633149000733	GIY-YIG motif/motif A; other site
633149000734	putative metal binding site [ion binding]; other site
633149000735	ATP-dependent chaperone ClpB; Region: chaperone_ClpB; TIGR03346
633149000736	Clp amino terminal domain; Region: Clp_N; pfam02861
633149000737	Clp amino terminal domain; Region: Clp_N; pfam02861
633149000738	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
633149000739	Walker A motif; other site
633149000740	ATP binding site [chemical binding]; other site
633149000741	Walker B motif; other site
633149000742	arginine finger; other site
633149000743	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
633149000744	Walker A motif; other site
633149000745	ATP binding site [chemical binding]; other site
633149000746	Walker B motif; other site
633149000747	arginine finger; other site
633149000748	C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431
633149000749	Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280
633149000750	Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629
633149000751	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
633149000752	N-terminal plug; other site
633149000753	ligand-binding site [chemical binding]; other site
633149000754	Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680
633149000755	Beta-lactamase; Region: Beta-lactamase; pfam00144
633149000756	Domain of unknown function (DUF3471); Region: DUF3471; pfam11954
633149000757	2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases [Coenzyme metabolism / Energy production and conversion]; Region: UbiH; COG0654
633149000758	ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314
633149000759	ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314
633149000760	Pentose-5-phosphate-3-epimerase [Carbohydrate transport and metabolism]; Region: Rpe; COG0036
633149000761	Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose...; Region: RPE; cd00429
633149000762	substrate binding site [chemical binding]; other site
633149000763	hexamer interface [polypeptide binding]; other site
633149000764	metal binding site [ion binding]; metal-binding site
633149000765	Heparinase II/III-like protein; Region: Hepar_II_III; cl15421
633149000766	Uncharacterized protein conserved in bacteria (DUF2236); Region: DUF2236; pfam09995
633149000767	bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; Provisional; Region: purH; PRK00881
633149000768	Inosine monophosphate cyclohydrolase domain. This is the N-terminal domain in the purine biosynthesis pathway protein ATIC (purH). The bifunctional ATIC protein contains a C-terminal  ATIC formylase domain that formylates...; Region: IMPCH; cd01421
633149000769	purine monophosphate binding site [chemical binding]; other site
633149000770	dimer interface [polypeptide binding]; other site
633149000771	putative catalytic residues [active]
633149000772	AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; smart00798
633149000773	AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; cl03362
633149000774	Dienelactone hydrolase family; Region: DLH; pfam01738
633149000775	OsmC-like protein; Region: OsmC; cl00767
633149000776	Predicted acetyltransferase [General function prediction only]; Region: COG3393
633149000777	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
633149000778	Coenzyme A binding pocket [chemical binding]; other site
633149000779	tryptophanyl-tRNA synthetase II; Reviewed; Region: PRK12282
633149000780	catalytic core domain of tryptophanyl-tRNA synthetase; Region: TrpRS_core; cd00806
633149000781	active site
633149000782	HIGH motif; other site
633149000783	dimer interface [polypeptide binding]; other site
633149000784	KMSKS motif; other site
633149000785	Uncharacterized membrane protein, putative virulence factor [General function prediction only]; Region: MviN; COG0728
633149000786	MurJ/MviN, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_MurJ_like; cd13123
633149000787	PII uridylyl-transferase; Provisional; Region: PRK05092
633149000788	Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401
633149000789	metal binding triad; other site
633149000790	GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335
633149000791	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
633149000792	Zn2+ binding site [ion binding]; other site
633149000793	Mg2+ binding site [ion binding]; other site
633149000794	ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141
633149000795	C-terminal ACT domains of the bacterial signal-transducing uridylyltransferase /uridylyl-removing (UUR) enzyme, GlnD and related domains; Region: ACT_ACR-UUR-like_2; cd04899
633149000796	DNA mismatch repair protein MutS; Provisional; Region: PRK05399
633149000797	MutS domain I; Region: MutS_I; pfam01624
633149000798	MutS domain II; Region: MutS_II; pfam05188
633149000799	MutS domain III; Region: MutS_III; pfam05192
633149000800	MutS domain V; Region: MutS_V; pfam00488
633149000801	Walker A/P-loop; other site
633149000802	ATP binding site [chemical binding]; other site
633149000803	Q-loop/lid; other site
633149000804	ABC transporter signature motif; other site
633149000805	Walker B; other site
633149000806	D-loop; other site
633149000807	H-loop/switch region; other site
633149000808	Outer membrane cobalamin receptor protein [Coenzyme metabolism]; Region: BtuB; COG4206
633149000809	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
633149000810	N-terminal plug; other site
633149000811	ligand-binding site [chemical binding]; other site
633149000812	bifunctional regulator KidO; Provisional; Region: PRK14863
633149000813	Predicted phosphohydrolases [General function prediction only]; Region: Icc; COG1409
633149000814	Bacillus subtilis YydB and related proteins, metallophosphatase domain; Region: MPP_YydB; cd07400
633149000815	putative active site [active]
633149000816	putative metal binding site [ion binding]; other site
633149000817	Bacillus subtilis YydB and related proteins, metallophosphatase domain; Region: MPP_YydB; cd07400
633149000818	Sphingosine kinase and enzymes related to eukaryotic diacylglycerol kinase [Lipid metabolism / General function prediction only]; Region: LCB5; COG1597
633149000819	Diacylglycerol kinase catalytic domain; Region: DAGK_cat; pfam00781
633149000820	Methyltransferase domain; Region: Methyltransf_11; pfam08241
633149000821	comF family protein; Region: comF; TIGR00201
633149000822	Glutaredoxin (GRX) family, GRX bacterial class 1 and 3 (b_1_3)-like subfamily; composed of bacterial GRXs, approximately 10 kDa in size, and proteins containing a GRX or GRX-like domain. GRX is a glutathione (GSH) dependent reductase, catalyzing the...; Region: GRX_GRXb_1_3_like; cd03418
633149000823	GSH binding site [chemical binding]; other site
633149000824	catalytic residues [active]
633149000825	nitrilase; Region: PLN02798
633149000826	Nit1, Nit 2, and related proteins, and the Nit1-like domain of NitFhit (class 10 nitrilases); Region: nit; cd07572
633149000827	putative active site [active]
633149000828	catalytic triad [active]
633149000829	dimer interface [polypeptide binding]; other site
633149000830	Protein of unknown function (DUF1178); Region: DUF1178; pfam06676
633149000831	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182
633149000832	bifunctional 3-demethylubiquinone-9 3-methyltransferase/ 2-octaprenyl-6-hydroxy phenol methylase; Provisional; Region: PRK05134
633149000833	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
633149000834	S-adenosylmethionine binding site [chemical binding]; other site
633149000835	aspartate kinase; Reviewed; Region: PRK06635
633149000836	AAK_AKii-LysC-BS: Amino Acid Kinase Superfamily (AAK), AKii; this CD includes the N-terminal catalytic aspartokinase (AK) domain of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis 168, and the lysine plus threonine-sensitive...; Region: AAK_AKii-LysC-BS; cd04261
633149000837	putative nucleotide binding site [chemical binding]; other site
633149000838	putative catalytic residues [active]
633149000839	putative Mg ion binding site [ion binding]; other site
633149000840	putative aspartate binding site [chemical binding]; other site
633149000841	ACT domains of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related proteins; Region: ACT_AKii-LysC-BS-like_1; cd04913
633149000842	putative allosteric regulatory site; other site
633149000843	ACT domains of the lysine-sensitive, aspartokinase (AK) isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related domains; Region: ACT_AKii-LysC-BS-like_2; cd04936
633149000844	putative allosteric regulatory residue; other site
633149000845	Signal transduction protein containing GAF and PtsI domains [Signal transduction mechanisms]; Region: PtsP; COG3605
633149000846	Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065
633149000847	PEP-utilising enzyme, N-terminal; Region: PEP-utilisers_N; pfam05524
633149000848	PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391
633149000849	PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896
633149000850	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
633149000851	non-specific DNA binding site [nucleotide binding]; other site
633149000852	salt bridge; other site
633149000853	sequence-specific DNA binding site [nucleotide binding]; other site
633149000854	Domain of unknown function (DUF4115); Region: DUF4115; pfam13464
633149000855	4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Reviewed; Region: ispG; PRK00366
633149000856	4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694
633149000857	Sulfite exporter TauE/SafE; Region: TauE; pfam01925
633149000858	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
633149000859	active site
633149000860	phosphorylation site [posttranslational modification]
633149000861	intermolecular recognition site; other site
633149000862	dimerization interface [polypeptide binding]; other site
633149000863	peptide chain release factor 1; Validated; Region: prfA; PRK00591
633149000864	This domain is found in peptide chain release factors; Region: PCRF; smart00937
633149000865	RF-1 domain; Region: RF-1; pfam00472
633149000866	Cytochrome C assembly protein; Region: Cytochrom_C_asm; cl00504
633149000867	Heme exporter protein D (CcmD); Region: CcmD; cl11475
633149000868	Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388
633149000869	Thioredoxin-like; Region: Thioredoxin_8; pfam13905
633149000870	MarR family; Region: MarR_2; pfam12802
633149000871	Intracellular septation protein A; Region: IspA; cl01098
633149000872	signal recognition particle-docking protein FtsY; Provisional; Region: PRK10416
633149000873	SRP54-type protein, helical bundle domain; Region: SRP54_N; pfam02881
633149000874	The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115
633149000875	P loop; other site
633149000876	GTP binding site [chemical binding]; other site
633149000877	NAD synthetase; Reviewed; Region: nadE; PRK02628
633149000878	Glutamine aminotransferase (GAT, glutaminase) domain of glutamine-dependent NAD synthetases (class 7 and 8 nitrilases); Region: GAT_Gln-NAD-synth; cd07570
633149000879	multimer interface [polypeptide binding]; other site
633149000880	active site
633149000881	catalytic triad [active]
633149000882	protein interface 1 [polypeptide binding]; other site
633149000883	NAD+ synthase is a homodimer, which catalyzes the final step in de novo nicotinamide adenine dinucleotide (NAD+) biosynthesis, an amide transfer from either ammonia or glutamine to nicotinic acid adenine dinucleotide (NaAD). The conversion of NaAD to NAD...; Region: NAD_synthase; cd00553
633149000884	homodimer interface [polypeptide binding]; other site
633149000885	NAD binding pocket [chemical binding]; other site
633149000886	ATP binding pocket [chemical binding]; other site
633149000887	Mg binding site [ion binding]; other site
633149000888	active-site loop [active]
633149000889	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
633149000890	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
633149000891	Amidohydrolase; Region: Amidohydro_4; pfam13147
633149000892	active site
633149000893	PhnA protein; Region: PhnA; pfam03831
633149000894	Uncharacterized Zn-ribbon-containing protein involved in phosphonate metabolism [Inorganic ion transport and metabolism]; Region: PhnA; COG2824
633149000895	Putative lysophospholipase; Region: Hydrolase_4; pfam12146
633149000896	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
633149000897	histidinol-phosphate phosphatase family domain; Region: Histidinol-ppas; TIGR01656
633149000898	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
633149000899	active site
633149000900	motif I; other site
633149000901	motif II; other site
633149000902	Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WecE; COG0399
633149000903	3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616
633149000904	inhibitor-cofactor binding pocket; inhibition site
633149000905	pyridoxal 5'-phosphate binding site [chemical binding]; other site
633149000906	catalytic residue [active]
633149000907	Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673
633149000908	Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408
633149000909	Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894
633149000910	Aldehyde dehydrogenase family; Region: Aldedh; pfam00171
633149000911	Mycobacterium tuberculosis succinate-semialdehyde dehydrogenase 1-like; Region: ALDH_SSADH1_GabD1; cd07100
633149000912	NAD(P) binding site [chemical binding]; other site
633149000913	catalytic residues [active]
633149000914	MHYT domain (predicted integral membrane sensor domain) [Signal transduction mechanisms]; Region: COG3300
633149000915	Bacterial signalling protein N terminal repeat; Region: MHYT; pfam03707
633149000916	Bacterial signalling protein N terminal repeat; Region: MHYT; pfam03707
633149000917	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920
633149000918	HWE histidine kinase; Region: HWE_HK; pfam07536
633149000919	NodN (nodulation factor N) contains a single hot dog fold similar to those of the peroxisomal Hydratase-Dehydrogenase-Epimerase (HDE) protein, and the fatty acid synthase beta subunit.  Rhizobium and related species form nodules on the roots of their...; Region: NodN; cd03450
633149000920	putative active site [active]
633149000921	putative catalytic site [active]
633149000922	Threonine dehydratase [Amino acid transport and metabolism]; Region: IlvA; COG1171
633149000923	Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562
633149000924	tetramer interface [polypeptide binding]; other site
633149000925	pyridoxal 5'-phosphate binding site [chemical binding]; other site
633149000926	catalytic residue [active]
633149000927	Escherichia coli glycerol kinase-like proteins; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_EcGK_like; cd07786
633149000928	N- and C-terminal domain interface [polypeptide binding]; other site
633149000929	glycerol kinase; Region: glycerol_kin; TIGR01311
633149000930	active site
633149000931	MgATP binding site [chemical binding]; other site
633149000932	catalytic site [active]
633149000933	metal binding site [ion binding]; metal-binding site
633149000934	glycerol binding site [chemical binding]; other site
633149000935	homotetramer interface [polypeptide binding]; other site
633149000936	homodimer interface [polypeptide binding]; other site
633149000937	FBP binding site [chemical binding]; other site
633149000938	protein IIAGlc interface [polypeptide binding]; other site
633149000939	Acyl-CoA dehydrogenase (ACAD) 10 and 11, N-terminal domain, and similar proteins. This subfamily is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs); Region: ACAD10_11_like; cd05154
633149000940	Phosphotransferase enzyme family; Region: APH; pfam01636
633149000941	putative active site [active]
633149000942	putative substrate binding site [chemical binding]; other site
633149000943	ATP binding site [chemical binding]; other site
633149000944	Ribosomal protein L20; Region: Ribosomal_L20; cd07026
633149000945	23S rRNA binding site [nucleotide binding]; other site
633149000946	L21 binding site [polypeptide binding]; other site
633149000947	L13 binding site [polypeptide binding]; other site
633149000948	50S ribosomal protein L35; Reviewed; Region: rpmI; PRK00172
633149000949	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
633149000950	putative substrate translocation pore; other site
633149000951	Major Facilitator Superfamily; Region: MFS_1; pfam07690
633149000952	The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354
633149000953	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
633149000954	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
633149000955	dimer interface [polypeptide binding]; other site
633149000956	phosphorylation site [posttranslational modification]
633149000957	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
633149000958	ATP binding site [chemical binding]; other site
633149000959	Mg2+ binding site [ion binding]; other site
633149000960	G-X-G motif; other site
633149000961	Response regulator receiver domain; Region: Response_reg; pfam00072
633149000962	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
633149000963	active site
633149000964	phosphorylation site [posttranslational modification]
633149000965	intermolecular recognition site; other site
633149000966	dimerization interface [polypeptide binding]; other site
633149000967	Dipeptidyl aminopeptidases/acylaminoacyl-peptidases [Amino acid transport and metabolism]; Region: DAP2; COG1506
633149000968	Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326
633149000969	translation initiation factor IF-3; Reviewed; Region: infC; PRK00028
633149000970	Translation initiation factor IF-3, N-terminal domain; Region: IF3_N; pfam05198
633149000971	Translation initiation factor IF-3, C-terminal domain; Region: IF3_C; pfam00707
633149000972	ADP-heptose:LPS heptosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaF; COG0859
633149000973	Lipopolysaccharide heptosyltransferase is involved in the biosynthesis of lipooligosaccharide (LOS). Lipopolysaccharide (LPS) is a major component of the outer membrane of gram-negative bacteria. LPS heptosyltransferase transfers heptose molecules from...; Region: GT1_LPS_heptosyltransferase; cd03789
633149000974	putative active site [active]
633149000975	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
633149000976	Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326
633149000977	Scaffold protein Nfu/NifU N terminal; Region: Nfu_N; pfam08712
633149000978	Thioredoxin-like proteins and domains [Posttranslational modification, protein turnover, chaperones]; Region: COG0694
633149000979	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
633149000980	Ligand Binding Site [chemical binding]; other site
633149000981	Bacterial NAD-glutamate dehydrogenase; Region: Bac_GDH; pfam05088
633149000982	Outer membrane protein beta-barrel domain; Region: OMP_b-brl; cl17254
633149000983	Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628
633149000984	Domain of unknown function DUF20; Region: UPF0118; pfam01594
633149000985	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
633149000986	Bacterial protein of unknown function (DUF853); Region: DUF853; pfam05872
633149000987	Walker A motif; other site
633149000988	ATP binding site [chemical binding]; other site
633149000989	Sensors of blue-light using FAD; Region: BLUF; pfam04940
633149000990	MltA specific insert domain; Region: MltA; cl08398
633149000991	3D domain; Region: 3D; pfam06725
633149000992	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4395
633149000993	Preprotein translocase subunit SecB [Intracellular trafficking and secretion]; Region: SecB; COG1952
633149000994	SecA binding site; other site
633149000995	Preprotein binding site; other site
633149000996	DNA polymerase III, epsilon subunit, Proteobacterial; Region: dnaQ_proteo; TIGR01406
633149000997	DEDDh 3'-5' exonuclease domain of the epsilon subunit of Escherichia coli DNA polymerase III and similar proteins; Region: DNA_pol_III_epsilon_Ecoli_like; cd06131
633149000998	active site
633149000999	catalytic site [active]
633149001000	substrate binding site [chemical binding]; other site
633149001001	Dephospho-CoA kinase [Coenzyme metabolism]; Region: CoaE; COG0237
633149001002	Dephospho-coenzyme A kinase (DPCK, EC 2.7.1.24) catalyzes the phosphorylation of dephosphocoenzyme A (dCoA) to yield CoA, which is the final step in CoA biosynthesis; Region: DPCK; cd02022
633149001003	CoA-binding site [chemical binding]; other site
633149001004	ATP-binding [chemical binding]; other site
633149001005	shikimate 5-dehydrogenase; Reviewed; Region: aroE; PRK00258
633149001006	Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501
633149001007	NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065
633149001008	shikimate binding site; other site
633149001009	NAD(P) binding site [chemical binding]; other site
633149001010	Maf-like protein; Provisional; Region: PRK14361
633149001011	Nucleotide binding protein Maf. Maf has been implicated in inhibition of septum formation in eukaryotes, bacteria and archaea, but homologs in B.subtilis and S.cerevisiae are nonessential for cell division. Maf has been predicted to be a nucleotide- or...; Region: Maf; cd00555
633149001012	active site
633149001013	dimer interface [polypeptide binding]; other site
633149001014	PEP synthetase regulatory protein; Provisional; Region: PRK05339
633149001015	Uroporphyrinogen decarboxylase (URO-D) is a dimeric cytosolic enzyme that decarboxylates the four acetate side chains of uroporphyrinogen III (uro-III) to create coproporphyrinogen III, without requiring any prosthetic groups or cofactors. This reaction...; Region: URO-D; cd00717
633149001016	substrate binding site [chemical binding]; other site
633149001017	active site
633149001018	ferrochelatase; Reviewed; Region: hemH; PRK00035
633149001019	Ferrochelatase, N-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_N; cd03411
633149001020	C-terminal domain interface [polypeptide binding]; other site
633149001021	active site
633149001022	Ferrochelatase, C-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_C; cd00419
633149001023	active site
633149001024	N-terminal domain interface [polypeptide binding]; other site
633149001025	Uncharacterized protein family (UPF0093); Region: UPF0093; pfam03653
633149001026	transcription termination factor Rho; Provisional; Region: rho; PRK09376
633149001027	Rho termination factor, N-terminal domain; Region: Rho_N; pfam07498
633149001028	Rho_CSD: Rho protein cold-shock domain (CSD). Rho protein is a transcription termination factor in most bacteria. In bacteria, there are two distinct mechanisms for mRNA transcription termination. In intrinsic termination, RNA polymerase and nascent mRNA...; Region: Rho_CSD; cd04459
633149001029	RNA binding site [nucleotide binding]; other site
633149001030	Transcription termination factor rho is a bacterial ATP-dependent RNA/DNA helicase. It is a homohexamer. Each monomer consists of an N-terminal domain of the OB fold, which is responsible for binding to cysteine rich nucleotides. This alignment is of the...; Region: rho_factor; cd01128
633149001031	multimer interface [polypeptide binding]; other site
633149001032	Walker A motif; other site
633149001033	ATP binding site [chemical binding]; other site
633149001034	Walker B motif; other site
633149001035	Quinone oxidoreductase (QOR); Region: QOR2; cd05286
633149001036	quinone oxidoreductase, NADPH-dependent; Provisional; Region: PRK10754
633149001037	NADP binding site [chemical binding]; other site
633149001038	dimer interface [polypeptide binding]; other site
633149001039	tRNA modification GTPase TrmE; Reviewed; Region: trmE; PRK05291
633149001040	GTP-binding protein TrmE N-terminus; Region: TrmE_N; pfam10396
633149001041	trmE is a tRNA modification GTPase; Region: trmE; cd04164
633149001042	G1 box; other site
633149001043	GTP/Mg2+ binding site [chemical binding]; other site
633149001044	Switch I region; other site
633149001045	G2 box; other site
633149001046	Switch II region; other site
633149001047	G3 box; other site
633149001048	G4 box; other site
633149001049	G5 box; other site
633149001050	Catalytic cysteine-containing C-terminus of GTPase, MnmE; Region: GTPase_Cys_C; pfam12631
633149001051	tRNA uridine 5-carboxymethylaminomethyl modification enzyme GidA; Validated; Region: PRK05192
633149001052	tRNA (uracil-5-)-methyltransferase Gid; Reviewed; Region: PRK05335
633149001053	GidA associated domain 3; Region: GIDA_assoc_3; pfam13932
633149001054	Predicted S-adenosylmethionine-dependent methyltransferase involved in bacterial cell division [Cell envelope biogenesis, outer membrane]; Region: GidB; COG0357
633149001055	16S rRNA methyltransferase GidB; Reviewed; Region: gidB; PRK00107
633149001056	ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192
633149001057	ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042
633149001058	P-loop; other site
633149001059	Magnesium ion binding site [ion binding]; other site
633149001060	ParB/RepB/Spo0J family partition protein; Region: parB_part; TIGR00180
633149001061	ParB-like nuclease domain; Region: ParBc; pfam02195
633149001062	DNA polymerase III subunit delta; Reviewed; Region: holA; PRK06585
633149001063	Lipopolysaccharide-assembly; Region: LptE; cl01125
633149001064	leucyl-tRNA synthetase; Validated; Region: leuS; PRK00390
633149001065	catalytic core domain of leucyl-tRNA synthetases; Region: LeuRS_core; cd00812
633149001066	HIGH motif; other site
633149001067	Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603
633149001068	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
633149001069	active site
633149001070	KMSKS motif; other site
633149001071	Anticodon-binding domain of bacterial and eukaryotic mitochondrial leucyl tRNA synthetases; Region: Anticodon_Ia_Leu_BEm; cd07958
633149001072	tRNA binding surface [nucleotide binding]; other site
633149001073	Domain of unknown function (DUF3576); Region: DUF3576; pfam12100
633149001074	Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5-; Region: TMP_TenI; cd00564
633149001075	pyrophosphate binding site [ion binding]; other site
633149001076	Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes, YBL036c-like proteins; Region: PLPDE_III_YBL036c_like; cd00635
633149001077	pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site
633149001078	catalytic residue [active]
633149001079	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
633149001080	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
633149001081	active site
633149001082	phosphorylation site [posttranslational modification]
633149001083	intermolecular recognition site; other site
633149001084	dimerization interface [polypeptide binding]; other site
633149001085	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
633149001086	DNA binding site [nucleotide binding]
633149001087	ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314
633149001088	Ubiquinone biosynthesis hydroxylase, UbiH/UbiF/VisC/COQ6 family; Region: Ubi-OHases; TIGR01988
633149001089	molecular chaperone DnaK; Provisional; Region: dnaK; PRK00290
633149001090	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037
633149001091	nucleotide binding site [chemical binding]; other site
633149001092	chaperone protein DnaJ; Provisional; Region: PRK10767
633149001093	DnaJ domain or J-domain.  DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257
633149001094	HSP70 interaction site [polypeptide binding]; other site
633149001095	C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cl03262
633149001096	substrate binding site [polypeptide binding]; other site
633149001097	Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719
633149001098	Zn binding sites [ion binding]; other site
633149001099	C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747
633149001100	dimer interface [polypeptide binding]; other site
633149001101	dihydrodipicolinate reductase; Provisional; Region: PRK00048
633149001102	Dihydrodipicolinate reductase, N-terminus; Region: DapB_N; pfam01113
633149001103	Dihydrodipicolinate reductase, C-terminus; Region: DapB_C; pfam05173
633149001104	tRNA (guanine-N(7)-)-methyltransferase; Reviewed; Region: trmB; PRK00121
633149001105	S-adenosylmethionine synthetase; Validated; Region: PRK05250
633149001106	S-adenosylmethionine synthetase, N-terminal domain; Region: S-AdoMet_synt_N; pfam00438
633149001107	S-adenosylmethionine synthetase, central domain; Region: S-AdoMet_synt_M; pfam02772
633149001108	S-adenosylmethionine synthetase, C-terminal domain; Region: S-AdoMet_synt_C; pfam02773
633149001109	Carbonic anhydrase alpha, prokaryotic-like subfamily. Carbonic anhydrases (CAs) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism: a nucleophilic attack of a zinc-bound hydroxide ion on carbon...; Region: alpha_CA_prokaryotic_like; cd03124
633149001110	active site
633149001111	zinc binding site [ion binding]; other site
633149001112	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244
633149001113	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244
633149001114	ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042
633149001115	CobQ/CobB/MinD/ParA nucleotide binding domain; Region: CbiA; pfam01656
633149001116	P-loop; other site
633149001117	Magnesium ion binding site [ion binding]; other site
633149001118	Curli production assembly/transport component CsgG; Region: CsgG; cl17434
633149001119	helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cl17320
633149001120	non-specific DNA interactions [nucleotide binding]; other site
633149001121	DNA binding site [nucleotide binding]
633149001122	sequence specific DNA binding site [nucleotide binding]; other site
633149001123	putative cAMP binding site [chemical binding]; other site
633149001124	AbgT putative transporter family; Region: ABG_transport; cl17431
633149001125	Flp pilus assembly protein TadG [Intracellular trafficking and secretion]; Region: TadG; COG4961
633149001126	TadE-like protein; Region: TadE; pfam07811
633149001127	Predicted membrane protein [Function unknown]; Region: COG4655
633149001128	Tetratricopeptide repeat; Region: TPR_16; pfam13432
633149001129	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
633149001130	binding surface
633149001131	TPR motif; other site
633149001132	Putative Ig domain; Region: He_PIG; pfam05345
633149001133	Autotransporter beta-domain; Region: Autotransporter; smart00869
633149001134	filamentous hemagglutinin family N-terminal domain; Region: adhes_NPXG; TIGR01901
633149001135	FG-GAP repeat; Region: FG-GAP_2; pfam14312
633149001136	FG-GAP repeat; Region: FG-GAP_2; pfam14312
633149001137	FG-GAP repeat; Region: FG-GAP_2; pfam14312
633149001138	Hemolysin activation/secretion protein [Intracellular trafficking and secretion]; Region: FhaC; COG2831
633149001139	POTRA domain, ShlB-type; Region: POTRA_2; pfam08479
633149001140	Uroporphyrinogen-III synthase (HemD) catalyzes the asymmetrical cyclization of tetrapyrrole (linear) to uroporphyrinogen-III, the fourth step in the biosynthesis of heme. This ubiquitous enzyme is present in eukaryotes, bacteria and archaea. Mutations in...; Region: HemD; cd06578
633149001141	porphobilinogen deaminase; Reviewed; Region: hemC; PRK00072
633149001142	Hydroxymethylbilane synthase (HMBS), also known as porphobilinogen deaminase (PBGD), is an intermediate enzyme in the biosynthetic pathway of tetrapyrrolic ring systems, such as heme, chlorophylls, and vitamin B12. HMBS catalyzes the conversion of...; Region: HMBS; cl17708
633149001143	domain interfaces; other site
633149001144	active site
633149001145	UGMP family protein; Validated; Region: PRK09604
633149001146	NAD(P)H-dependent glycerol-3-phosphate dehydrogenase; Validated; Region: gpsA; PRK00094
633149001147	NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210
633149001148	NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus; Region: NAD_Gly3P_dh_C; pfam07479
633149001149	Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cd03467
633149001150	iron-sulfur cluster [ion binding]; other site
633149001151	[2Fe-2S] cluster binding site [ion binding]; other site
633149001152	Creatinine amidohydrolase; Region: Creatininase; pfam02633
633149001153	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
633149001154	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
633149001155	AefR-like transcriptional repressor, C-terminal region; Region: TetR_C_7; pfam14246
633149001156	drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711
633149001157	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
633149001158	putative substrate translocation pore; other site
633149001159	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
633149001160	Multidrug resistance efflux pump [Defense mechanisms]; Region: EmrA; COG1566
633149001161	HlyD family secretion protein; Region: HlyD_3; pfam13437
633149001162	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
633149001163	Flavin containing amine oxidoreductase; Region: Amino_oxidase; pfam01593
633149001164	Predicted EndoIII-related endonuclease [DNA replication, recombination, and repair]; Region: Nth; COG0177
633149001165	endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056
633149001166	minor groove reading motif; other site
633149001167	helix-hairpin-helix signature motif; other site
633149001168	substrate binding pocket [chemical binding]; other site
633149001169	active site
633149001170	Iron-sulfur binding domain of endonuclease III; Region: EndIII_4Fe-2S; pfam10576
633149001171	Beta-lactamase; Region: Beta-lactamase; pfam00144
633149001172	Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680
633149001173	ATP-grasp domain; Region: ATP-grasp_4; cl17255
633149001174	Adenosine kinase (AK) catalyzes the phosphorylation of ribofuranosyl-containing nucleoside analogues at the 5'-hydroxyl using ATP or GTP as the phosphate donor.The physiological function of AK is associated with the regulation of extracellular...; Region: adenosine_kinase; cd01168
633149001175	Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524
633149001176	substrate binding site [chemical binding]; other site
633149001177	ATP binding site [chemical binding]; other site
633149001178	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2840
633149001179	Smr domain; Region: Smr; pfam01713
633149001180	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
633149001181	non-specific DNA binding site [nucleotide binding]; other site
633149001182	salt bridge; other site
633149001183	sequence-specific DNA binding site [nucleotide binding]; other site
633149001184	Protein of unknown function (DUF2975); Region: DUF2975; pfam11188
633149001185	NTPase/HAM1.  This family consists of the HAM1 protein and pyrophosphate-releasing xanthosine/ inosine triphosphatase. HAM1 protects the cell against mutagenesis by the base analog 6-N-hydroxylaminopurine (HAP) in E. Coli and S. cerevisiae. A...; Region: HAM1; cd00515
633149001186	active site
633149001187	dimerization interface [polypeptide binding]; other site
633149001188	coproporphyrinogen III oxidase; Provisional; Region: PRK09057
633149001189	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
633149001190	FeS/SAM binding site; other site
633149001191	HemN C-terminal domain; Region: HemN_C; pfam06969
633149001192	Predicted methyltransferases [General function prediction only]; Region: COG0313
633149001193	Ribosomal RNA small subunit methyltransferase I, also known as rRNA (cytidine-2'-O-)-methyltransferase RsmI; Region: RsmI; cd11648
633149001194	putative SAM binding site [chemical binding]; other site
633149001195	putative homodimer interface [polypeptide binding]; other site
633149001196	hypothetical protein; Reviewed; Region: PRK12497
633149001197	Transglutaminase-like superfamily; Region: Transglut_core2; pfam13369
633149001198	cellulose synthase catalytic subunit; Provisional; Region: bcsA; PRK11498
633149001199	Ferredoxin [Energy production and conversion]; Region: Fdx; COG0633
633149001200	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
633149001201	catalytic loop [active]
633149001202	iron binding site [ion binding]; other site
633149001203	succinate dehydrogenase iron-sulfur subunit; Reviewed; Region: sdhB; PRK05950
633149001204	2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_3; pfam13085
633149001205	succinate dehydrogenase flavoprotein subunit; Reviewed; Region: sdhA; PRK09078
633149001206	L-aspartate oxidase; Provisional; Region: PRK06175
633149001207	Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910
633149001208	Succinate:quinone oxidoreductase (SQR) and Quinol:fumarate reductase (QFR) family, transmembrane subunits; SQR catalyzes the oxidation of succinate to fumarate coupled to the reduction of quinone to quinol, while QFR catalyzes the reverse reaction. SQR; Region: SQR_QFR_TM; cl00881
633149001209	Iron-sulfur protein interface; other site
633149001210	proximal heme binding site [chemical binding]; other site
633149001211	Succinate:quinone oxidoreductase (SQR) Type C subfamily, Succinate dehydrogenase C (SdhC) subunit; composed of bacterial SdhC and eukaryotic large cytochrome b binding (CybL) proteins. SQR catalyzes the oxidation of succinate to fumarate coupled to the...; Region: SQR_TypeC_SdhC; cd03499
633149001212	Iron-sulfur protein interface; other site
633149001213	proximal quinone binding site [chemical binding]; other site
633149001214	SdhD (CybS) interface [polypeptide binding]; other site
633149001215	proximal heme binding site [chemical binding]; other site
633149001216	HIT family: HIT (Histidine triad) proteins, named for a motif related to the sequence HxHxH/Qxx (x, a hydrophobic amino acid), are a superfamily of nucleotide hydrolases and transferases, which act on the alpha-phosphate of ribonucleotides. On the basis...; Region: HIT_like; cl00228
633149001217	Protein of unknown function (DUF541); Region: SIMPL; pfam04402
633149001218	malate dehydrogenase; Reviewed; Region: PRK06223
633149001219	L-lactate dehydrogenase-like malate dehydrogenase proteins; Region: LDH-like_MDH; cd01339
633149001220	NAD(P) binding site [chemical binding]; other site
633149001221	dimer interface [polypeptide binding]; other site
633149001222	tetramer (dimer of dimers) interface [polypeptide binding]; other site
633149001223	substrate binding site [chemical binding]; other site
633149001224	Putative bacterial sensory transduction regulator; Region: YbjN; pfam10722
633149001225	Predicted ATPase [General function prediction only]; Region: COG1485
633149001226	AAA ATPase domain; Region: AAA_16; pfam13191
633149001227	aspartate-semialdehyde dehydrogenase; Provisional; Region: PRK14874
633149001228	Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859
633149001229	Predicted permeases [General function prediction only]; Region: RarD; COG2962
633149001230	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
633149001231	Major Facilitator Superfamily; Region: MFS_1; pfam07690
633149001232	putative substrate translocation pore; other site
633149001233	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
633149001234	Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680
633149001235	Beta-lactamase; Region: Beta-lactamase; pfam00144
633149001236	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
633149001237	uncharacterized flavoprotein, PP_4765 family; Region: flavo_PP4765; TIGR03862
633149001238	transcription elongation factor regulatory protein; Validated; Region: PRK06342
633149001239	Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272
633149001240	Bacterial pre-peptidase C-terminal domain; Region: PPC; pfam04151
633149001241	Protein of unknown function (DUF1223); Region: DUF1223; cl10501
633149001242	Serine proteases of the peptidase family S9A [Amino acid transport and metabolism]; Region: COG1505
633149001243	Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326
633149001244	Serine proteases of the peptidase family S9A [Amino acid transport and metabolism]; Region: COG1505
633149001245	Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326
633149001246	Ion channel; Region: Ion_trans_2; pfam07885
633149001247	Protein required for attachment to host cells; Region: Host_attach; cl02398
633149001248	diaminopimelate epimerase; Provisional; Region: dapF; PRK00450
633149001249	Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678
633149001250	Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678
633149001251	Protein of unknown function (DUF1674); Region: DUF1674; pfam07896
633149001252	argininosuccinate synthase; Provisional; Region: PRK13820
633149001253	Argininosuccinate synthase. The Argininosuccinate synthase is a urea cycle enzyme that catalyzes the penultimate step in arginine biosynthesis: the ATP-dependent ligation of citrulline to aspartate to form argininosuccinate, AMP and pyrophosphate .  In...; Region: Argininosuccinate_Synthase; cd01999
633149001254	ANP binding site [chemical binding]; other site
633149001255	Substrate Binding Site II [chemical binding]; other site
633149001256	Substrate Binding Site I [chemical binding]; other site
633149001257	Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804
633149001258	CoA-transferase family III; Region: CoA_transf_3; pfam02515
633149001259	PIN domain of ribonucleases (toxins), VapC and FitB, of prokaryotic toxin/antitoxin operons, Pyrococcus horikoshii protein PH0500, and other similar bacterial and archaeal homologs; Region: PIN_VapC-FitB; cd09881
633149001260	oligomeric interface; other site
633149001261	homodimer interface [polypeptide binding]; other site
633149001262	putative active site [active]
633149001263	Virulence-associated protein and related proteins [Function unknown]; Region: VagC; COG4456
633149001264	dihydrolipoamide succinyltransferase; Validated; Region: PRK05704
633149001265	Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849
633149001266	E3 interaction surface; other site
633149001267	lipoyl attachment site [posttranslational modification]; other site
633149001268	e3 binding domain; Region: E3_binding; pfam02817
633149001269	2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198
633149001270	2-oxoglutarate dehydrogenase E1 component; Reviewed; Region: sucA; PRK09404
633149001271	Thiamine pyrophosphate (TPP) family, E1 of OGDC-like subfamily, TPP-binding module; composed of proteins similar to the E1 component of the 2-oxoglutarate dehydrogenase multienzyme complex (OGDC). OGDC catalyzes the oxidative decarboxylation of...; Region: TPP_E1_OGDC_like; cd02016
633149001272	TPP-binding site [chemical binding]; other site
633149001273	Transketolase, pyrimidine binding domain; Region: Transket_pyr; pfam02779
633149001274	succinyl-CoA synthetase subunit alpha; Validated; Region: PRK05678
633149001275	CoA binding domain; Region: CoA_binding; smart00881
633149001276	CoA-ligase; Region: Ligase_CoA; pfam00549
633149001277	succinyl-CoA synthetase subunit beta; Provisional; Region: sucC; PRK00696
633149001278	ATP-grasp domain; Region: ATP-grasp_2; pfam08442
633149001279	CoA-ligase; Region: Ligase_CoA; pfam00549
633149001280	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
633149001281	Major Facilitator Superfamily; Region: MFS_1; pfam07690
633149001282	putative substrate translocation pore; other site
633149001283	Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629
633149001284	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
633149001285	N-terminal plug; other site
633149001286	ligand-binding site [chemical binding]; other site
633149001287	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
633149001288	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
633149001289	Predicted membrane protein (DUF2306); Region: DUF2306; cl02232
633149001290	Uncharacterized protein conserved in bacteria (DUF2141); Region: DUF2141; pfam09912
633149001291	Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms]; Region: LytT; COG3279
633149001292	LytTr DNA-binding domain; Region: LytTR; pfam04397
633149001293	Lignostilbene-alpha,beta-dioxygenase and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3670
633149001294	Retinal pigment epithelial membrane protein; Region: RPE65; pfam03055
633149001295	Uncharacterized protein conserved in bacteria (DUF2141); Region: DUF2141; pfam09912
633149001296	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4529
633149001297	FAD-NAD(P)-binding; Region: NAD_binding_9; pfam13454
633149001298	START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643
633149001299	hydrophobic ligand binding site; other site
633149001300	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
633149001301	dimerization interface [polypeptide binding]; other site
633149001302	putative DNA binding site [nucleotide binding]; other site
633149001303	putative Zn2+ binding site [ion binding]; other site
633149001304	phosphoglucosamine mutase; Provisional; Region: glmM; PRK14315
633149001305	GlmM is a bacterial phosphoglucosamine mutase (PNGM) that belongs to the alpha-D-phosphohexomutase superfamily. It is required for the interconversion of glucosamine-6-phosphate and glucosamine-1-phosphate in the biosynthetic pathway of...; Region: GlmM; cd05802
633149001306	active site
633149001307	substrate binding site [chemical binding]; other site
633149001308	metal binding site [ion binding]; metal-binding site
633149001309	glucosamine--fructose-6-phosphate aminotransferase; Reviewed; Region: PRK00331
633149001310	Glutamine amidotransferases class-II (Gn-AT)_GFAT-type. This domain is found at the N-terminus of glucosamine-6P synthase (GlmS, or GFAT in humans).  The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the appropriate substrate. In...; Region: GFAT; cd00714
633149001311	glutaminase active site [active]
633149001312	SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008
633149001313	dimer interface [polypeptide binding]; other site
633149001314	active site
633149001315	SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009
633149001316	dimer interface [polypeptide binding]; other site
633149001317	active site
633149001318	Prokaryotic UGPase catalyses the synthesis of UDP-glucose; Region: UGPase_prokaryotic; cd02541
633149001319	active site
633149001320	tetramer interface; other site
633149001321	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
633149001322	Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451
633149001323	NAD(P) binding site [chemical binding]; other site
633149001324	active site
633149001325	atypical (a) SDRs, subgroup 4; Region: SDR_a4; cd05266
633149001326	Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451
633149001327	putative NAD(P) binding site [chemical binding]; other site
633149001328	Protein of unknown function (DUF1134); Region: DUF1134; cl02235
633149001329	hypothetical protein; Provisional; Region: PRK05208
633149001330	phenylalanyl-tRNA synthetase subunit beta; Reviewed; Region: pheT; PRK00629
633149001331	tRNA-binding-domain-containing prokaryotic phenylalanly tRNA synthetase (PheRS) beta chain.  PheRS aminoacylate phenylalanine transfer RNAs (tRNAphe). PheRSs belong structurally to class II aminoacyl tRNA synthetases (aaRSs) but, as they aminoacylate...; Region: tRNA_bind_bactPheRS; cd02796
633149001332	putative tRNA-binding site [nucleotide binding]; other site
633149001333	B3/4 domain; Region: B3_4; pfam03483
633149001334	tRNA synthetase B5 domain; Region: B5; smart00874
633149001335	Phenylalanyl-tRNA synthetase (PheRS) beta chain core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure. While class II aaRSs generally aminoacylate the 3'-OH ribose of the appropriate tRNA,  PheRS is an...; Region: PheRS_beta_core; cd00769
633149001336	dimer interface [polypeptide binding]; other site
633149001337	motif 1; other site
633149001338	motif 3; other site
633149001339	motif 2; other site
633149001340	Ferredoxin-fold anticodon binding domain; Region: FDX-ACB; smart00896
633149001341	phenylalanyl-tRNA synthetase subunit alpha; Validated; Region: pheS; PRK00488
633149001342	Aminoacyl tRNA synthetase class II, N-terminal domain; Region: Phe_tRNA-synt_N; pfam02912
633149001343	Phenylalanyl-tRNA synthetase (PheRS) alpha chain catalytic core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs. This domain is primarily responsible...; Region: PheRS_alpha_core; cd00496
633149001344	dimer interface [polypeptide binding]; other site
633149001345	motif 1; other site
633149001346	active site
633149001347	motif 2; other site
633149001348	motif 3; other site
633149001349	Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea.  CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458
633149001350	DNA-binding site [nucleotide binding]; DNA binding site
633149001351	RNA-binding motif; other site
633149001352	Virulence factor BrkB; Region: Virul_fac_BrkB; pfam03631
633149001353	Uncharacterized Fe-S protein [General function prediction only]; Region: COG3217
633149001354	MOSC N-terminal beta barrel domain; Region: MOSC_N; pfam03476
633149001355	MOSC domain; Region: MOSC; pfam03473
633149001356	N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase; Provisional; Region: PRK09328
633149001357	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
633149001358	S-adenosylmethionine binding site [chemical binding]; other site
633149001359	Domain of unknown function (DUF4167); Region: DUF4167; pfam13763
633149001360	NusB family; Region: NusB; pfam01029
633149001361	putative RNA binding site [nucleotide binding]; other site
633149001362	tRNA and rRNA cytosine-C5-methylases [Translation, ribosomal structure and biogenesis]; Region: Sun; COG0144
633149001363	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
633149001364	S-adenosylmethionine binding site [chemical binding]; other site
633149001365	K+ transporter [Inorganic ion transport and metabolism]; Region: Kup; COG3158
633149001366	potassium uptake protein; Region: kup; TIGR00794
633149001367	Predicted transcriptional regulator [Transcription]; Region: COG1959
633149001368	Transcriptional regulator; Region: Rrf2; pfam02082
633149001369	Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300
633149001370	classical (c) SDRs; Region: SDR_c; cd05233
633149001371	NAD(P) binding site [chemical binding]; other site
633149001372	active site
633149001373	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
633149001374	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
633149001375	sequence-specific DNA binding site [nucleotide binding]; other site
633149001376	salt bridge; other site
633149001377	Putative Acyltransferase (AT), Left-handed parallel beta-Helix (LbH) domain; This group is composed of mostly uncharacterized proteins containing an N-terminal helical subdomain followed by a LbH domain. The alignment contains 6 turns, each containing...; Region: LbH_AT_putative; cd03360
633149001378	sugar O-acyltransferase, sialic acid O-acetyltransferase NeuD family; Region: NeuD_NnaD; TIGR03570
633149001379	putative trimer interface [polypeptide binding]; other site
633149001380	putative CoA binding site [chemical binding]; other site
633149001381	N-acetylneuraminate synthase; Region: NeuB_NnaB; TIGR03569
633149001382	NeuB family; Region: NeuB; pfam03102
633149001383	C-terminal SAF domain of sialic acid synthetase; Region: SAF_NeuB_like; cd11615
633149001384	NeuB binding interface [polypeptide binding]; other site
633149001385	putative substrate binding site [chemical binding]; other site
633149001386	Multiple antibiotic transporter [Intracellular trafficking and secretion]; Region: MarC; COG2095
633149001387	Orotidine 5'-phosphate decarboxylase (ODCase) is a dimeric enzyme that decarboxylates orotidine 5'-monophosphate (OMP) to form uridine 5'-phosphate (UMP), an essential step in the pyrimidine biosynthetic pathway. In mammals, UMP synthase...; Region: OMP_decarboxylase_like; cd04725
633149001388	active site
633149001389	dimer interface [polypeptide binding]; other site
633149001390	bifunctional malic enzyme oxidoreductase/phosphotransacetylase; Reviewed; Region: PRK07232
633149001391	Malic enzyme, N-terminal domain; Region: malic; pfam00390
633149001392	NAD(P) binding domain of malic enzyme (ME), subgroup 2; Region: NAD_bind_2_malic_enz; cd05311
633149001393	putative NAD(P) binding site [chemical binding]; other site
633149001394	Phosphotransacetylase [Energy production and conversion]; Region: Pta; COG0280
633149001395	muropeptide transporter; Validated; Region: ampG; cl17669
633149001396	muropeptide transporter; Validated; Region: ampG; cl17669
633149001397	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
633149001398	dimer interface [polypeptide binding]; other site
633149001399	phosphorylation site [posttranslational modification]
633149001400	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
633149001401	ATP binding site [chemical binding]; other site
633149001402	Mg2+ binding site [ion binding]; other site
633149001403	G-X-G motif; other site
633149001404	Response regulator receiver domain; Region: Response_reg; pfam00072
633149001405	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
633149001406	active site
633149001407	phosphorylation site [posttranslational modification]
633149001408	intermolecular recognition site; other site
633149001409	dimerization interface [polypeptide binding]; other site
633149001410	Predicted ATPase with chaperone activity [Posttranslational modification, protein turnover, chaperones]; Region: COG0606
633149001411	Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541
633149001412	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
633149001413	Walker A motif; other site
633149001414	ATP binding site [chemical binding]; other site
633149001415	Walker B motif; other site
633149001416	Magnesium chelatase, subunit ChlI; Region: Mg_chelatase_2; pfam13335
633149001417	glutathione synthetase; Provisional; Region: PRK05246
633149001418	Prokaryotic glutathione synthetase, N-terminal domain; Region: GSH-S_N; pfam02951
633149001419	Prokaryotic glutathione synthetase, ATP-grasp domain; Region: GSH-S_ATP; pfam02955
633149001420	haloacid dehalogenase-like hydrolase; Region: HAD; cl17202
633149001421	PAS fold; Region: PAS_7; pfam12860
633149001422	Signal transduction histidine kinase, nitrogen specific [Signal transduction mechanisms]; Region: NtrB; COG3852
633149001423	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
633149001424	dimer interface [polypeptide binding]; other site
633149001425	phosphorylation site [posttranslational modification]
633149001426	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
633149001427	ATP binding site [chemical binding]; other site
633149001428	Mg2+ binding site [ion binding]; other site
633149001429	G-X-G motif; other site
633149001430	Minimal MMP-like domain found in Acidothermus cellulolyticus hypothetical protein ACEL2062 and similar protein; Region: MMP_ACEL2062; cd12952
633149001431	Protein of unknown function (DUF3072); Region: DUF3072; pfam11272
633149001432	Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612
633149001433	Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675
633149001434	Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193
633149001435	Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612
633149001436	Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675
633149001437	Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193
633149001438	ATP-dependent DNA ligase; Reviewed; Region: ligD; PRK05972
633149001439	DNA ligase D, 3'-phosphoesterase domain; Region: LigD_PE_dom; TIGR02777
633149001440	Adenylation domain of Mycobacterium tuberculosis LigD and LigC-like ATP-dependent DNA ligases; Region: Adenylation_DNA_ligase_LigD_LigC; cd07906
633149001441	active site
633149001442	DNA binding site [nucleotide binding]
633149001443	The Oligonucleotide/oligosaccharide binding (OB)-fold domain of ATP-dependent DNA ligase LigD is a DNA-binding module that is part of the catalytic core unit; Region: OBF_DNA_ligase_LigD; cd07971
633149001444	DNA binding site [nucleotide binding]
633149001445	PaeLigD_Pol_like: Polymerase (Pol) domain of bacterial LigD proteins similar to Pseudomonas aeruginosa (Pae) LigD. The LigD Pol domain belongs to the archaeal/eukaryal primase (AEP) superfamily. In prokaryotes, LigD along with Ku is required for...; Region: PaeLigD_Pol_like; cd04862
633149001446	nucleotide binding site [chemical binding]; other site
633149001447	Protein of unknown function DUF45; Region: DUF45; pfam01863
633149001448	Poly-beta-hydroxyalkanoate depolymerase [Lipid metabolism]; Region: DepA; COG4553
633149001449	PHB de-polymerase C-terminus; Region: PHB_depo_C; pfam06850
633149001450	SCO (an acronym for Synthesis of Cytochrome c Oxidase) family; composed of proteins similar to Sco1, a membrane-anchored protein possessing a soluble domain with a TRX fold. Members of this family are required for the proper assembly of cytochrome c...; Region: SCO; cd02968
633149001451	Thioredoxin-like; Region: Thioredoxin_8; pfam13905
633149001452	Cu(I) binding site [ion binding]; other site
633149001453	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
633149001454	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
633149001455	ATP binding site [chemical binding]; other site
633149001456	Mg2+ binding site [ion binding]; other site
633149001457	G-X-G motif; other site
633149001458	Response regulator consisting of a CheY-like receiver domain and a Fis-type HTH domain [Signal transduction mechanisms / Transcription]; Region: COG4567
633149001459	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
633149001460	active site
633149001461	phosphorylation site [posttranslational modification]
633149001462	intermolecular recognition site; other site
633149001463	dimerization interface [polypeptide binding]; other site
633149001464	Bacterial regulatory protein, Fis family; Region: HTH_8; cl17420
633149001465	Protein of unknown function (DUF1052); Region: DUF1052; cl02197
633149001466	Lipocalin-like domain; Region: Lipocalin_2; pfam08212
633149001467	Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302
633149001468	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182
633149001469	2'-5' RNA ligase; Region: 2_5_ligase; TIGR02258
633149001470	LigT like Phosphoesterase; Region: LigT_PEase; pfam02834
633149001471	Integral membrane protein, interacts with FtsH [General function prediction only]; Region: COG0670
633149001472	Bacterial BAX inhibitor (BI)-1/YccA-like proteins; Region: BI-1-like_bacterial; cd10432
633149001473	Protein of unknown function (DUF2794); Region: DUF2794; pfam10984
633149001474	Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365
633149001475	PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987
633149001476	protein binding site [polypeptide binding]; other site
633149001477	PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987
633149001478	protein binding site [polypeptide binding]; other site
633149001479	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
633149001480	ligand binding domain of Tar- and Tsr-related chemoreceptors; Region: Tar_Tsr_LBD; cl00144
633149001481	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
633149001482	ATP binding site [chemical binding]; other site
633149001483	Mg2+ binding site [ion binding]; other site
633149001484	G-X-G motif; other site
633149001485	DNA-binding transcriptional regulator PhoP; Provisional; Region: PRK10816
633149001486	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
633149001487	active site
633149001488	phosphorylation site [posttranslational modification]
633149001489	intermolecular recognition site; other site
633149001490	dimerization interface [polypeptide binding]; other site
633149001491	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cl17355
633149001492	DNA binding site [nucleotide binding]
633149001493	Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cd00531
633149001494	Glutaryl-CoA dehydrogenase; Region: GCD; cd01151
633149001495	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
633149001496	FAD binding site [chemical binding]; other site
633149001497	substrate binding pocket [chemical binding]; other site
633149001498	catalytic base [active]
633149001499	Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612
633149001500	Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675
633149001501	Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193
633149001502	Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612
633149001503	Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675
633149001504	Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193
633149001505	L-Asparaginase type 2. L-Asparaginase hydrolyzes L-asparagine to L-aspartate and ammonia. The proenzyme undergoes an autoproteolytic cleavage into alpha and beta subunits to expose a threonine residue which becomes the N-terminal residue of the beta...; Region: Asparaginase_2; cd04701
633149001506	catalytic nucleophile [active]
633149001507	NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604
633149001508	Quinone oxidoreductase (QOR); Region: QOR1; cd08241
633149001509	NAD(P) binding site [chemical binding]; other site
633149001510	2OG-Fe(II) oxygenase superfamily; Region: 2OG-FeII_Oxy_3; pfam13640
633149001511	2OG-Fe(II) oxygenase superfamily; Region: 2OG-FeII_Oxy_3; pfam13640
633149001512	Uncharacterized conserved protein [Function unknown]; Region: COG3339
633149001513	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
633149001514	3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557
633149001515	NAD(P) binding site [chemical binding]; other site
633149001516	active site
633149001517	Phytase; Region: Phytase; cl17685
633149001518	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
633149001519	N-terminal plug; other site
633149001520	TonB-dependent receptor; Region: TonB-Xanth-Caul; TIGR01782
633149001521	ligand-binding site [chemical binding]; other site
633149001522	PAS domain; Region: PAS_10; pfam13596
633149001523	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
633149001524	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
633149001525	ATP binding site [chemical binding]; other site
633149001526	Mg2+ binding site [ion binding]; other site
633149001527	G-X-G motif; other site
633149001528	dihydrolipoamide dehydrogenase; Reviewed; Region: PRK06115
633149001529	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
633149001530	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
633149001531	Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852
633149001532	Bacterial aspartate proteases, retropepsin-like protease family; Region: retropepsin_like_bacteria; cd05483
633149001533	catalytic motif [active]
633149001534	Catalytic residue [active]
633149001535	Cellular and retroviral pepsin-like aspartate proteases; Region: pepsin_retropepsin_like; cl11403
633149001536	catalytic motif [active]
633149001537	Catalytic residue [active]
633149001538	Aspartyl protease; Region: Asp_protease_2; pfam13650
633149001539	inhibitor binding site; inhibition site
633149001540	catalytic motif [active]
633149001541	Catalytic residue [active]
633149001542	Active site flap [active]
633149001543	Cellular and retroviral pepsin-like aspartate proteases; Region: pepsin_retropepsin_like; cl11403
633149001544	site-specific tyrosine recombinase XerC; Reviewed; Region: xerC; PRK00236
633149001545	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
633149001546	active site
633149001547	DNA binding site [nucleotide binding]
633149001548	Int/Topo IB signature motif; other site
633149001549	Protein of unknown function, DUF484; Region: DUF484; cl17449
633149001550	Transaldolase-like fructose-6-phosphate aldolases (FSA) found in bacteria and archaea; Region: Transaldolase_FSA; cd00956
633149001551	active site
633149001552	intersubunit interactions; other site
633149001553	catalytic residue [active]
633149001554	primosome assembly protein PriA; Validated; Region: PRK05580
633149001555	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
633149001556	ATP binding site [chemical binding]; other site
633149001557	putative Mg++ binding site [ion binding]; other site
633149001558	helicase superfamily c-terminal domain; Region: HELICc; smart00490
633149001559	Transglycosylase; Region: Transgly; pfam00912
633149001560	penicillin-binding protein, 1A family; Region: PBP_1a_fam; TIGR02074
633149001561	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905
633149001562	Methyltransferase domain; Region: Methyltransf_23; pfam13489
633149001563	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
633149001564	S-adenosylmethionine binding site [chemical binding]; other site
633149001565	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
633149001566	Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638
633149001567	Rieske non-heme iron oxygenase (RO) family, N-terminal Rieske domain of the oxygenase alpha subunit; The RO family comprise a large class of aromatic ring-hydroxylating dioxygenases found predominantly in microorganisms. These enzymes enable...; Region: Rieske_RO_Alpha_N; cd03469
633149001568	[2Fe-2S] cluster binding site [ion binding]; other site
633149001569	START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643
633149001570	hydrophobic ligand binding site; other site
633149001571	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
633149001572	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
633149001573	Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; COG0475
633149001574	TrkA-N domain; Region: TrkA_N; pfam02254
633149001575	Predicted metalloendopeptidase [Posttranslational modification, protein turnover, chaperones]; Region: PepO; COG3590
633149001576	Peptidase family M13 includes neprilysin, endothelin-converting enzyme I; Region: M13; cd08662
633149001577	active site
633149001578	Zn binding site [ion binding]; other site
633149001579	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
633149001580	Pentapeptide repeats containing protein [Function unknown]; Region: COG1357
633149001581	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
633149001582	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
633149001583	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
633149001584	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
633149001585	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
633149001586	Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599
633149001587	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
633149001588	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
633149001589	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
633149001590	Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599
633149001591	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
633149001592	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
633149001593	Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599
633149001594	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
633149001595	Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071
633149001596	Alpha-crystallin domain (ACD) found in Escherichia coli inclusion body-associated proteins IbpA and IbpB, and similar proteins.  IbpA and IbpB are 16 kDa small heat shock proteins (sHsps). sHsps are molecular chaperones that suppress protein aggregation...; Region: ACD_IbpA-B_like; cd06470
633149001597	putative dimer interface [polypeptide binding]; other site
633149001598	Predicted methyltransferase [General function prediction only]; Region: COG4798
633149001599	Methyltransferase domain; Region: Methyltransf_23; pfam13489
633149001600	Predicted methyltransferase [General function prediction only]; Region: COG4798
633149001601	Methyltransferase domain; Region: Methyltransf_23; pfam13489
633149001602	Lysophospholipase [Lipid metabolism]; Region: PldB; COG2267
633149001603	Putative lysophospholipase; Region: Hydrolase_4; pfam12146
633149001604	Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483
633149001605	Predominantly bacterial family of Mg++ dependend phosphatases, related to inositol monophosphatases. These enzymes may dephosphorylate fructose-1,6-bisphosphate, inositol monophospate, 3'-phosphoadenosine-5'-phosphate,  or similar substrates; Region: Bacterial_IMPase_like_1; cd01641
633149001606	active site
633149001607	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
633149001608	sequence-specific DNA binding site [nucleotide binding]; other site
633149001609	salt bridge; other site
633149001610	Lactate dehydrogenase and related dehydrogenases [Energy production and conversion / Coenzyme metabolism / General function prediction only]; Region: LdhA; COG1052
633149001611	D-glycerate dehydrogenase/hydroxypyruvate reductase (GDH); Region: GDH; cd05301
633149001612	dimerization interface [polypeptide binding]; other site
633149001613	ligand binding site [chemical binding]; other site
633149001614	NADP binding site [chemical binding]; other site
633149001615	catalytic site [active]
633149001616	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3807
633149001617	Bacterial SH3 domain; Region: SH3_4; pfam06347
633149001618	Bacterial SH3 domain; Region: SH3_4; pfam06347
633149001619	FabA, beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase: Bacterial protein of the type II, fatty acid synthase system that binds ACP and catalyzes both dehydration and isomerization reactions, apparently in the same active site. The FabA...; Region: FabA; cd01287
633149001620	active site 1 [active]
633149001621	dimer interface [polypeptide binding]; other site
633149001622	active site 2 [active]
633149001623	3-oxoacyl-(acyl carrier protein) synthase I; Reviewed; Region: PRK07967
633149001624	Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834
633149001625	dimer interface [polypeptide binding]; other site
633149001626	active site
633149001627	Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876
633149001628	PA: Protease-associated (PA) domain. The PA domain is an insert domain in a diverse fraction of proteases. The significance of the PA domain to many of the proteins in which it is inserted is undetermined. It may be a protein-protein interaction domain; Region: PA; cl08238
633149001629	PA/protease or protease-like domain interface [polypeptide binding]; other site
633149001630	Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876
633149001631	Peptidase family M28; Region: Peptidase_M28; pfam04389
633149001632	metal binding site [ion binding]; metal-binding site
633149001633	Enoyl-[acyl-carrier-protein]; Region: FabI; COG0623
633149001634	Enoyl acyl carrier protein (ACP) reductase (ENR), divergent SDR; Region: ENR_SDR; cd05372
633149001635	NAD binding site [chemical binding]; other site
633149001636	homotetramer interface [polypeptide binding]; other site
633149001637	homodimer interface [polypeptide binding]; other site
633149001638	substrate binding site [chemical binding]; other site
633149001639	active site
633149001640	Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_oxidase; pfam01243
633149001641	Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625
633149001642	GST_N family, Ure2p-like subfamily; composed of the Saccharomyces cerevisiae Ure2p and related GSTs. Ure2p is a regulator for nitrogen catabolism in yeast. It represses the expression of several gene products involved in the use of poor nitrogen sources...; Region: GST_N_Ure2p_like; cd03048
633149001643	C-terminal domain interface [polypeptide binding]; other site
633149001644	GSH binding site (G-site) [chemical binding]; other site
633149001645	dimer interface [polypeptide binding]; other site
633149001646	C-terminal, alpha helical domain of Ure2p and related Glutathione S-transferase-like proteins; Region: GST_C_Ure2p_like; cd03178
633149001647	dimer interface [polypeptide binding]; other site
633149001648	N-terminal domain interface [polypeptide binding]; other site
633149001649	Domain of unknown function (DUF1508); Region: DUF1508; cl01356
633149001650	RimM N-terminal domain; Region: RimM; pfam01782
633149001651	16S rRNA-processing protein RimM; Provisional; Region: rimM; PRK13828
633149001652	PRC-barrel domain; Region: PRC; pfam05239
633149001653	30S ribosomal protein S16; Reviewed; Region: rpsP; PRK00040
633149001654	signal recognition particle protein; Provisional; Region: PRK10867
633149001655	SRP54-type protein, helical bundle domain; Region: SRP54_N; smart00963
633149001656	The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115
633149001657	P loop; other site
633149001658	GTP binding site [chemical binding]; other site
633149001659	Signal peptide binding domain; Region: SRP_SPB; pfam02978
633149001660	phosphoenolpyruvate carboxylase; Reviewed; Region: PRK00009
633149001661	Phosphoenolpyruvate carboxylase [Energy production and conversion]; Region: Ppc; COG2352
633149001662	recombination protein RecR; Reviewed; Region: recR; PRK00076
633149001663	RecR protein; Region: RecR; pfam02132
633149001664	TOPRIM_recR: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in Escherichia coli RecR.  RecR participates in the RecFOR pathway of homologous recombinational repair in prokaryotes. This pathway provides a...; Region: TOPRIM_recR; cd01025
633149001665	putative active site [active]
633149001666	putative metal-binding site [ion binding]; other site
633149001667	tetramer interface [polypeptide binding]; other site
633149001668	hypothetical protein; Provisional; Region: PRK14625
633149001669	DNA polymerase III subunits gamma and tau; Validated; Region: PRK09111
633149001670	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
633149001671	Walker A motif; other site
633149001672	ATP binding site [chemical binding]; other site
633149001673	Walker B motif; other site
633149001674	arginine finger; other site
633149001675	DNA polymerase III subunits gamma and tau domain III; Region: DNA_pol3_gamma3; pfam12169
633149001676	DNA polymerase III gamma and tau subunits C terminal; Region: DUF3646; pfam12362
633149001677	Domain of unknown function (DUF3597); Region: DUF3597; pfam12200
633149001678	short chain dehydrogenase; Provisional; Region: PRK06180
633149001679	17beta hydroxysteroid dehydrogenase-like, classical (c) SDRs; Region: 17beta-HSD-like_SDR_c; cd05374
633149001680	NADP binding site [chemical binding]; other site
633149001681	active site
633149001682	steroid binding site; other site
633149001683	NTP pyrophosphohydrolases containing a Zn-finger, probably nucleic-acid-binding [DNA replication, recombination, and repair]; Region: NPY1; COG2816
633149001684	NADH pyrophosphatase-like rudimentary NUDIX domain; Region: NUDIX-like; pfam09296
633149001685	NADH pyrophosphatase zinc ribbon domain; Region: zf-NADH-PPase; pfam09297
633149001686	NADH pyrophosphatase, a member of the Nudix hydrolase superfamily, catalyzes the cleavage of NADH into reduced nicotinamide mononucleotide (NMNH) and AMP. Like other members of the Nudix family, it requires a divalent cation, such as Mg2+ or Mn2+, for...; Region: NADH_pyrophosphatase; cd03429
633149001687	putative NADH binding site [chemical binding]; other site
633149001688	putative active site [active]
633149001689	nudix motif; other site
633149001690	putative metal binding site [ion binding]; other site
633149001691	3-deoxy-manno-octulosonate cytidylyltransferase; Provisional; Region: PRK05450
633149001692	CMP-KDO synthetase catalyzes the activation of KDO which is an essential component of the lipopolysaccharide; Region: CMP-KDO-Synthetase; cd02517
633149001693	Ligand binding site; other site
633149001694	oligomer interface; other site
633149001695	Cytochrome c2 [Energy production and conversion]; Region: COG3474
633149001696	Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791
633149001697	NlpC/P60 family; Region: NLPC_P60; cl17555
633149001698	Cytosol aminopeptidase family, N-terminal and catalytic domains.  Family M17 contains zinc- and manganese-dependent exopeptidases ( EC  3.4.11.1), including leucine aminopeptidase. They catalyze removal of amino acids from the N-terminus of a protein and...; Region: Peptidase_M17; cd00433
633149001699	interface (dimer of trimers) [polypeptide binding]; other site
633149001700	Substrate-binding/catalytic site; other site
633149001701	Zn-binding sites [ion binding]; other site
633149001702	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
633149001703	binding surface
633149001704	TPR motif; other site
633149001705	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
633149001706	binding surface
633149001707	TPR motif; other site
633149001708	NifU homolog involved in Fe-S cluster formation [Energy production and conversion]; Region: IscU; COG0822
633149001709	Iron-sulfur cluster scaffold-like proteins; Region: IscU_like; cd06664
633149001710	trimerization site [polypeptide binding]; other site
633149001711	active site
633149001712	hypothetical protein; Validated; Region: PRK00041
633149001713	threonyl-tRNA synthetase; Reviewed; Region: thrS; PRK00413
633149001714	TGS _ThrRS_N:  ThrRS (threonyl-tRNA Synthetase)  is a class II tRNA synthetase that couples threonine to its cognate tRNA.  In addition to its catalytic and anticodon-binding domains, ThrRS has an N-terminal TGS domain, named after the ThrRS, GTPase, and...; Region: TGS_ThrRS_N; cd01667
633149001715	Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; pfam07973
633149001716	Threonyl-tRNA synthetase (ThrRS) class II core catalytic domain. ThrRS is a homodimer. It is responsible for the attachment of threonine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ThrRS_core; cd00771
633149001717	active site
633149001718	dimer interface [polypeptide binding]; other site
633149001719	motif 1; other site
633149001720	motif 2; other site
633149001721	motif 3; other site
633149001722	ThrRS Threonyl-anticodon binding domain. ThrRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: ThrRS_anticodon; cd00860
633149001723	anticodon binding site; other site
633149001724	cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664
633149001725	Crp-like helix-turn-helix domain; Region: HTH_Crp_2; pfam13545
633149001726	YciF bacterial stress response protein, ferritin-like iron-binding domain; Region: YciF; cd07909
633149001727	dimerization interface [polypeptide binding]; other site
633149001728	metal binding site [ion binding]; metal-binding site
633149001729	acetyl-CoA acetyltransferase; Validated; Region: PRK08242
633149001730	Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751
633149001731	dimer interface [polypeptide binding]; other site
633149001732	active site
633149001733	multifunctional fatty acid oxidation complex subunit alpha; Reviewed; Region: fadJ; PRK11154
633149001734	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
633149001735	substrate binding site [chemical binding]; other site
633149001736	oxyanion hole (OAH) forming residues; other site
633149001737	trimer interface [polypeptide binding]; other site
633149001738	3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737
633149001739	3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725
633149001740	3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725
633149001741	Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596
633149001742	diaminopimelate decarboxylase; Region: lysA; TIGR01048
633149001743	Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Diaminopimelate Decarboxylase; Region: PLPDE_III_DapDC; cd06828
633149001744	active site
633149001745	pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site
633149001746	substrate binding site [chemical binding]; other site
633149001747	catalytic residues [active]
633149001748	dimer interface [polypeptide binding]; other site
633149001749	argininosuccinate lyase; Provisional; Region: PRK00855
633149001750	Argininosuccinate lyase (argininosuccinase, ASAL); Region: Argininosuccinate_lyase; cd01359
633149001751	active sites [active]
633149001752	tetramer interface [polypeptide binding]; other site
633149001753	TlpA-like family; composed of  TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966
633149001754	Thioredoxin-like; Region: Thioredoxin_8; pfam13905
633149001755	catalytic residues [active]
633149001756	dehydrogenase, PQQ-dependent, s-GDH family; Region: non_repeat_PQQ; TIGR03606
633149001757	Glucose / Sorbosone dehydrogenase; Region: GSDH; pfam07995
633149001758	GcrA cell cycle regulator; Region: GcrA; cl11564
633149001759	CO2+/MG2+ efflux protein ApaG; Reviewed; Region: apaG; PRK05461
633149001760	2'-deoxycytidine 5'-triphosphate deaminase; Provisional; Region: PRK07559
633149001761	Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cl00493
633149001762	trimer interface [polypeptide binding]; other site
633149001763	active site
633149001764	Deoxycytidine deaminase [Nucleotide transport and metabolism]; Region: Dcd; COG0717
633149001765	trimer interface [polypeptide binding]; other site
633149001766	active site
633149001767	enterobactin exporter EntS; Provisional; Region: PRK10489
633149001768	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
633149001769	putative substrate translocation pore; other site
633149001770	Uncharacterized conserved protein, contains double-stranded beta-helix domain [Function unknown]; Region: COG3837
633149001771	succinyl-diaminopimelate desuccinylase; Reviewed; Region: PRK13009
633149001772	M20 Peptidase proteobacterial DapE encoded N-succinyl-L,L-diaminopimelic acid desuccinylase; Region: M20_DapE_proteobac; cd03891
633149001773	metal binding site [ion binding]; metal-binding site
633149001774	dimer interface [polypeptide binding]; other site
633149001775	Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473
633149001776	Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876
633149001777	metal binding site [ion binding]; metal-binding site
633149001778	Pyrabactin resistance 1 (PYR1), PYR1-like (PYL), regulatory component of abscisic acid receptors (RCARs), and related proteins; Region: PYR_PYL_RCAR_like; cd07821
633149001779	putative hydrophobic ligand binding site [chemical binding]; other site
633149001780	protein interface [polypeptide binding]; other site
633149001781	gate; other site
633149001782	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
633149001783	Major Facilitator Superfamily; Region: MFS_1; pfam07690
633149001784	putative substrate translocation pore; other site
633149001785	Ligand-binding SRPBCC domain of an uncharacterized subfamily of proteins; Region: SRPBCC_4; cd07822
633149001786	putative hydrophobic ligand binding site [chemical binding]; other site
633149001787	Flp pilus assembly protein TadC [Cell motility and secretion / Intracellular trafficking and secretion]; Region: TadC; COG2064
633149001788	Flp pilus assembly protein TadB [Intracellular trafficking and secretion]; Region: TadB; COG4965
633149001789	Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482
633149001790	Flp pilus assembly protein, ATPase CpaF [Intracellular trafficking and secretion]; Region: CpaF; COG4962
633149001791	Type IV secretory pathway component VirB11, and related ATPases. The homohexamer, VirB11 is one of eleven Vir proteins, which are required for T-pilus biogenesis and virulence in the transfer of T-DNA from the Ti (tumor-inducing) plasmid of bacterial to...; Region: VirB11-like_ATPase; cd01130
633149001792	ATP binding site [chemical binding]; other site
633149001793	Walker A motif; other site
633149001794	hexamer interface [polypeptide binding]; other site
633149001795	Walker B motif; other site
633149001796	Flp pilus assembly protein, ATPase CpaE [Intracellular trafficking and secretion]; Region: CpaE; COG4963
633149001797	This protein family consists of proteins similar to the cpaE protein of the Caulobacter pilus assembly and the orf4 protein of Actinobacillus pilus formation gene cluster. The function of these proteins are unkown. The Caulobacter pilus assembly contains...; Region: CpaE_like; cd03111
633149001798	Type IV pili component [Cell motility and secretion]; Region: COG5461
633149001799	Pilus biogenesis CpaD protein (pilus_cpaD); Region: Pilus_CpaD; pfam09476
633149001800	Pilus formation protein N terminal region; Region: T2SS-T3SS_pil_N; pfam13629
633149001801	Flp pilus assembly protein, secretin CpaC [Intracellular trafficking and secretion]; Region: CpaC; COG4964
633149001802	Bacterial type II and III secretion system protein; Region: Secretin; pfam00263
633149001803	Flp pilus assembly protein CpaB [Intracellular trafficking and secretion]; Region: CpaB; COG3745
633149001804	SAF domains of the flagella basal body P-ring formation protein FlgA and the flp pilus assembly CpaB; Region: SAF_CpaB_FlgA_like; cd11614
633149001805	Flp pilus assembly protein, protease CpaA [Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: CpaA; COG4960
633149001806	Flp/Fap pilin component; Region: Flp_Fap; cl01585
633149001807	Flp/Fap pilin component; Region: Flp_Fap; cl01585
633149001808	Pilus formation protein N terminal region; Region: T2SS-T3SS_pil_N; pfam13629
633149001809	Flp pilus assembly protein TadG [Intracellular trafficking and secretion]; Region: TadG; COG4961
633149001810	TadE-like protein; Region: TadE; pfam07811
633149001811	Flp pilus assembly protein TadG [Intracellular trafficking and secretion]; Region: TadG; COG4961
633149001812	TadE-like protein; Region: TadE; pfam07811
633149001813	aminodeoxychorismate synthase, component I, clade 2; Region: PabB-clade2; TIGR01824
633149001814	chorismate binding enzyme; Region: Chorismate_bind; pfam00425
633149001815	Protein tyrosine/serine phosphatase [Signal transduction mechanisms]; Region: COG2365
633149001816	Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr; Region: PTPc; cl00053
633149001817	active site
633149001818	Tyrosine phosphatase family C-terminal region; Region: Y_phosphatase3C; pfam13348
633149001819	Transcriptional regulators [Transcription]; Region: MarR; COG1846
633149001820	Winged helix DNA-binding domain; Region: HTH_34; pfam13601
633149001821	AMP nucleosidase; Provisional; Region: PRK08292
633149001822	Bacterial AMP nucleoside phosphorylase N-terminus; Region: AMNp_N; pfam10423
633149001823	Nucleoside phosphorylase [Nucleotide transport and metabolism]; Region: Pfs; COG0775
633149001824	alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859
633149001825	Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326
633149001826	Uncharacterized protein involved in outer membrane biogenesis [Cell envelope biogenesis, outer membrane]; Region: AsmA; COG2982
633149001827	AsmA-like C-terminal region; Region: AsmA_2; pfam13502
633149001828	ABC-type transport system involved in cytochrome c biogenesis, ATPase component [Posttranslational modification, protein turnover, chaperones]; Region: CcmA; COG4133
633149001829	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
633149001830	Walker A/P-loop; other site
633149001831	ATP binding site [chemical binding]; other site
633149001832	Q-loop/lid; other site
633149001833	ABC transporter signature motif; other site
633149001834	Walker B; other site
633149001835	D-loop; other site
633149001836	H-loop/switch region; other site
633149001837	aconitate hydratase; Validated; Region: PRK09277
633149001838	Aconitase A catalytic domain; Region: AcnA_IRP; cd01586
633149001839	substrate binding site [chemical binding]; other site
633149001840	ligand binding site [chemical binding]; other site
633149001841	Aconitase A swivel domain. This is the major form of the TCA cycle enzyme aconitate hydratase, also known as aconitase and citrate hydro-lyase. It includes bacterial and archaeal aconitase A, and the eukaryotic cytosolic form of aconitase. This group...; Region: AcnA_IRP_Swivel; cd01580
633149001842	substrate binding site [chemical binding]; other site
633149001843	Transcriptional regulator [Transcription]; Region: LysR; COG0583
633149001844	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
633149001845	The C-terminal substrate-binding domain of the LysR-type transcriptional regulator OxyR, a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_OxyR; cd08411
633149001846	dimerization interface [polypeptide binding]; other site
633149001847	Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450
633149001848	Peroxiredoxin (PRX) family, Typical 2-Cys PRX subfamily; PRXs are thiol-specific antioxidant (TSA) proteins, which confer a protective role in cells through its peroxidase activity by reducing hydrogen peroxide, peroxynitrite, and organic hydroperoxides; Region: PRX_Typ2cys; cd03015
633149001849	dimer interface [polypeptide binding]; other site
633149001850	decamer (pentamer of dimers) interface [polypeptide binding]; other site
633149001851	catalytic triad [active]
633149001852	peroxidatic and resolving cysteines [active]
633149001853	alkylhydroperoxidase, AhpD family; Region: ahpD; TIGR00777
633149001854	Carboxymuconolactone decarboxylase family; Region: CMD; pfam02627
633149001855	Asp/Glu/Hydantoin racemase; Region: Asp_Glu_race; cl00518
633149001856	Zn-dependent oligopeptidases [Amino acid transport and metabolism]; Region: Dcp; COG0339
633149001857	Peptidase family M3 dipeptidyl carboxypeptidase (DCP); Region: M3A_DCP; cd06456
633149001858	active site
633149001859	Zn binding site [ion binding]; other site
633149001860	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
633149001861	PAS fold; Region: PAS_3; pfam08447
633149001862	putative active site [active]
633149001863	heme pocket [chemical binding]; other site
633149001864	PAS domain S-box; Region: sensory_box; TIGR00229
633149001865	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
633149001866	putative active site [active]
633149001867	heme pocket [chemical binding]; other site
633149001868	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
633149001869	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
633149001870	dimer interface [polypeptide binding]; other site
633149001871	phosphorylation site [posttranslational modification]
633149001872	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
633149001873	ATP binding site [chemical binding]; other site
633149001874	Mg2+ binding site [ion binding]; other site
633149001875	G-X-G motif; other site
633149001876	Response regulator receiver domain; Region: Response_reg; pfam00072
633149001877	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
633149001878	active site
633149001879	phosphorylation site [posttranslational modification]
633149001880	intermolecular recognition site; other site
633149001881	dimerization interface [polypeptide binding]; other site
633149001882	RmuC family; Region: RmuC; pfam02646
633149001883	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
633149001884	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
633149001885	non-specific DNA binding site [nucleotide binding]; other site
633149001886	salt bridge; other site
633149001887	sequence-specific DNA binding site [nucleotide binding]; other site
633149001888	TraB family; Region: TraB; pfam01963
633149001889	Response regulator receiver domain; Region: Response_reg; pfam00072
633149001890	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
633149001891	active site
633149001892	phosphorylation site [posttranslational modification]
633149001893	intermolecular recognition site; other site
633149001894	dimerization interface [polypeptide binding]; other site
633149001895	CHASE3 domain; Region: CHASE3; pfam05227
633149001896	PAS domain S-box; Region: sensory_box; TIGR00229
633149001897	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
633149001898	putative active site [active]
633149001899	heme pocket [chemical binding]; other site
633149001900	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
633149001901	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
633149001902	dimer interface [polypeptide binding]; other site
633149001903	phosphorylation site [posttranslational modification]
633149001904	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
633149001905	ATP binding site [chemical binding]; other site
633149001906	Mg2+ binding site [ion binding]; other site
633149001907	G-X-G motif; other site
633149001908	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
633149001909	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
633149001910	active site
633149001911	phosphorylation site [posttranslational modification]
633149001912	intermolecular recognition site; other site
633149001913	dimerization interface [polypeptide binding]; other site
633149001914	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
633149001915	DNA binding residues [nucleotide binding]
633149001916	dimerization interface [polypeptide binding]; other site
633149001917	Histidine kinase; Region: HisKA_3; pfam07730
633149001918	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4337
633149001919	Protein of unknown function (DUF2490); Region: DUF2490; pfam10677
633149001920	Domain of unknown function (DUF897); Region: DUF897; cl01312
633149001921	Transcriptional regulator [Transcription]; Region: LysR; COG0583
633149001922	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
633149001923	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
633149001924	dimerization interface [polypeptide binding]; other site
633149001925	integral membrane protein, TerC family; Region: R_switched_Alx; TIGR03718
633149001926	Type II secretion system (T2SS), protein K; Region: T2SK; pfam03934
633149001927	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244
633149001928	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244
633149001929	Predicted metal-dependent hydrolase with the TIM-barrel fold [General function prediction only]; Region: COG1574
633149001930	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
633149001931	YtcJ_like metal dependent amidohydrolases. YtcJ is a Bacillus subtilis ORF of unknown function. The Arabidopsis homolog LAF3 has been identified as a factor required for photochrome A signalling; Region: YtcJ_like; cd01300
633149001932	active site
633149001933	Protein of unknown function, DUF488; Region: DUF488; pfam04343
633149001934	leukotriene A-4 hydrolase/aminopeptidase; Region: leuko_A4_hydro; TIGR02411
633149001935	Peptidase M1 family contains leukotriene A4 hydrolase; Region: M1_LTA4H; cd09599
633149001936	active site
633149001937	Zn binding site [ion binding]; other site
633149001938	Leukotriene A4 hydrolase, C-terminal; Region: Leuk-A4-hydro_C; pfam09127
633149001939	bicyclomycin/multidrug efflux system; Provisional; Region: PRK11102
633149001940	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
633149001941	putative substrate translocation pore; other site
633149001942	Gram-negative bacterial tonB protein; Region: TonB; cl10048
633149001943	beta-ketoadipate pathway transcriptional regulators, PcaR/PcaU/PobR family; Region: pcaR_pcaU; TIGR02431
633149001944	ATP-grasp domain; Region: ATP-grasp_4; cl17255
633149001945	dimethyl sulfone monooxygenase SfnG; Region: LLM_DMSO2_sfnG; TIGR04021
633149001946	Alkanesulfonate monoxygenase is the monoxygenase of a two-component system that catalyzes the conversion of alkanesulfonates to the corresponding aldehyde and sulfite. Alkanesulfonate monoxygenase (SsuD) has an absolute requirement for reduced flavin...; Region: Alkanesulfonate_monoxygenase; cd01094
633149001947	active site
633149001948	dimer interface [polypeptide binding]; other site
633149001949	non-prolyl cis peptide bond; other site
633149001950	insertion regions; other site
633149001951	Gram-negative bacterial tonB protein; Region: TonB; cl10048
633149001952	Demethoxyubiquinone hydroxylase, ferritin-like diiron-binding domain; Region: DMQH; cd01042
633149001953	diiron binding motif [ion binding]; other site
633149001954	Disulfide bond formation protein DsbB; Region: DsbB; pfam02600
633149001955	Exopolysaccharide synthesis, ExoD; Region: ExoD; pfam06055
633149001956	4-hydroxyphenylpyruvate dioxygenase and related hemolysins [Amino acid transport and metabolism / General function prediction only]; Region: COG3185
633149001957	N-terminal domain of 4-hydroxyphenylpyruvate dioxygenase (HPPD) and hydroxymandelate Synthase (HmaS); Region: HPPD_N_like; cd08342
633149001958	dimer interface [polypeptide binding]; other site
633149001959	C-terminal domain of 4-hydroxyphenylpyruvate dioxygenase (HppD) and hydroxymandelate Synthase (HmaS); Region: HPPD_C_like; cd07250
633149001960	active site
633149001961	Fe binding site [ion binding]; other site
633149001962	L-Asparaginase type 2. L-Asparaginase hydrolyzes L-asparagine to L-aspartate and ammonia. The proenzyme undergoes an autoproteolytic cleavage into alpha and beta subunits to expose a threonine residue which becomes the N-terminal residue of the beta...; Region: Asparaginase_2; cd04701
633149001963	catalytic nucleophile [active]
633149001964	2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179
633149001965	Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557
633149001966	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4246
633149001967	Esterase-like activity of phytase; Region: Phytase-like; pfam13449
633149001968	Cobalamin biosynthesis protein CobT; Region: CobT; pfam06213
633149001969	cobaltochelatase, CobT subunit; Region: CobT; TIGR01651
633149001970	norD type: Denitrifying bacteria contain both membrane bound and periplasmic nitrate reductases. Denitrification plays a major role  in completing the nitrogen cycle by converting nitrate or nitrite to nitrogen gas. The pathway for microbial...; Region: vWA_norD_type; cd01454
633149001971	metal ion-dependent adhesion site (MIDAS); other site
633149001972	YihA (EngB) GTPase family; Region: YihA_EngB; cd01876
633149001973	G1 box; other site
633149001974	GTP/Mg2+ binding site [chemical binding]; other site
633149001975	Switch I region; other site
633149001976	G2 box; other site
633149001977	G3 box; other site
633149001978	Switch II region; other site
633149001979	G4 box; other site
633149001980	G5 box; other site
633149001981	membrane protein insertase; Provisional; Region: PRK01318
633149001982	membrane protein insertase, YidC/Oxa1 family, C-terminal domain; Region: yidC_oxa1_cterm; TIGR03592
633149001983	Ribonuclease P; Region: Ribonuclease_P; pfam00825
633149001984	50S ribosomal protein L34; Reviewed; Region: rpmH; PRK00399
633149001985	Uncharacterized conserved protein [Function unknown]; Region: COG0398
633149001986	SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335
633149001987	Ferredoxin reductase (FNR), an FAD and NAD(P) binding protein, was intially identified as a chloroplast reductase activity, catalyzing the electron transfer from reduced iron-sulfur protein ferredoxin to NADP+ as the final step in the electron transport...; Region: FNR_like; cl06868
633149001988	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
633149001989	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
633149001990	ATP binding site [chemical binding]; other site
633149001991	Mg2+ binding site [ion binding]; other site
633149001992	G-X-G motif; other site
633149001993	Gamma-glutamyltransferase [Amino acid transport and metabolism]; Region: Ggt; COG0405
633149001994	Gamma-glutamyltranspeptidase; Region: G_glu_transpept; pfam01019
633149001995	Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185
633149001996	ligand binding site [chemical binding]; other site
633149001997	D-Lactate and related Dehydrogenases, NAD-binding and catalytic domains; Region: LDH_like_2; cd12183
633149001998	Lactate dehydrogenase and related dehydrogenases [Energy production and conversion / Coenzyme metabolism / General function prediction only]; Region: LdhA; COG1052
633149001999	putative ligand binding site [chemical binding]; other site
633149002000	putative NAD binding site [chemical binding]; other site
633149002001	catalytic site [active]
633149002002	Anion permease ArsB/NhaD.  These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life.  A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl17221
633149002003	TrkA-C domain; Region: TrkA_C; pfam02080
633149002004	Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; Region: CitT; COG0471
633149002005	TrkA-C domain; Region: TrkA_C; pfam02080
633149002006	Anion permease ArsB/NhaD.  These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life.  A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl17221
633149002007	Mechanosensitive ion channel; Region: MS_channel; pfam00924
633149002008	Putative phosphatase (DUF442); Region: DUF442; cl17385
633149002009	Uncharacterized NAD(FAD)-dependent dehydrogenases [General function prediction only]; Region: HcaD; COG0446
633149002010	Protein of unknown function (DUF2892); Region: DUF2892; pfam11127
633149002011	Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388
633149002012	Predicted transporter component [General function prediction only]; Region: COG2391
633149002013	Predicted transporter component [General function prediction only]; Region: COG2391
633149002014	Domain of unknown function (DUF4341); Region: DUF4341; pfam14241
633149002015	Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491
633149002016	Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450
633149002017	Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388
633149002018	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
633149002019	dimerization interface [polypeptide binding]; other site
633149002020	putative DNA binding site [nucleotide binding]; other site
633149002021	putative Zn2+ binding site [ion binding]; other site
633149002022	Protein of unknown function (DUF1275); Region: DUF1275; pfam06912
633149002023	Nodulin-21 and CCC1-related protein family; Region: Nodulin-21_like_1; cd02432
633149002024	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920
633149002025	Histidine kinase; Region: HisKA_2; pfam07568
633149002026	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
633149002027	ATP binding site [chemical binding]; other site
633149002028	Mg2+ binding site [ion binding]; other site
633149002029	G-X-G motif; other site
633149002030	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
633149002031	cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664
633149002032	ligand binding site [chemical binding]; other site
633149002033	flexible hinge region; other site
633149002034	helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092
633149002035	putative switch regulator; other site
633149002036	non-specific DNA interactions [nucleotide binding]; other site
633149002037	DNA binding site [nucleotide binding]
633149002038	sequence specific DNA binding site [nucleotide binding]; other site
633149002039	putative cAMP binding site [chemical binding]; other site
633149002040	Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010
633149002041	Cytochrome c; Region: Cytochrom_C; pfam00034
633149002042	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
633149002043	Ligand Binding Site [chemical binding]; other site
633149002044	succinate CoA transferase; Region: YgfH_subfam; TIGR03458
633149002045	Acetyl-CoA hydrolase/transferase N-terminal domain; Region: AcetylCoA_hydro; pfam02550
633149002046	Acetyl-CoA hydrolase/transferase C-terminal domain; Region: AcetylCoA_hyd_C; pfam13336
633149002047	Polymerase and Histidinol Phosphatase domain; Region: PHP; cl17102
633149002048	DNA polymerase alpha chain like domain; Region: POLIIIAc; smart00481
633149002049	active site
633149002050	TonB-dependent receptor; Region: TonB-Xanth-Caul; TIGR01782
633149002051	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244
633149002052	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244
633149002053	Tryptophan 2,3-dioxygenase (vermilion) [Amino acid transport and metabolism]; Region: TDO2; COG3483
633149002054	Response regulator receiver domain; Region: Response_reg; pfam00072
633149002055	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
633149002056	active site
633149002057	phosphorylation site [posttranslational modification]
633149002058	intermolecular recognition site; other site
633149002059	dimerization interface [polypeptide binding]; other site
633149002060	N-formylglutamate amidohydrolase; Region: FGase; pfam05013
633149002061	Protein of unknown function, DUF599; Region: DUF599; cl01575
633149002062	Inorganic pyrophosphatase. These enzymes hydrolyze inorganic pyrophosphate (PPi) to two molecules of orthophosphates (Pi). The reaction requires bivalent cations. The enzymes in general exist as homooligomers; Region: pyrophosphatase; cd00412
633149002063	dimer interface [polypeptide binding]; other site
633149002064	substrate binding site [chemical binding]; other site
633149002065	metal binding sites [ion binding]; metal-binding site
633149002066	This family is most closely related to the GT1 family of glycosyltransferases. mtfB (mannosyltransferase B) in E. coli has been shown to direct the growth of the O9-specific polysaccharide chain. It transfers two mannoses into the position 3 of the...; Region: GT1_mtfB_like; cd03809
633149002067	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
633149002068	D-arabinose 5-phosphate isomerase; Provisional; Region: PRK10892
633149002069	KpsF-like protein. KpsF is an arabinose-5-phosphate isomerase which contains SIS (Sugar ISomerase) domains. SIS domains are found in many phosphosugar isomerases and phosphosugar binding proteins. KpsF catalyzes the reversible reaction of ribulose...; Region: SIS_Kpsf; cd05014
633149002070	putative active site [active]
633149002071	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with KpsF/GutQ domains in the API [A5P (D-arabinose 5-phosphate) isomerase] protein.  These APIs catalyze the conversion of the pentose pathway...; Region: CBS_pair_KpsF_GutQ_assoc; cd04604
633149002072	trehalose-6-phosphate phosphatase; Provisional; Region: PRK10187; cl17105
633149002073	Trehalose-phosphatase; Region: Trehalose_PPase; pfam02358
633149002074	Glucoamylase and related glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: SGA1; COG3387
633149002075	Glycosyl hydrolases family 15; Region: Glyco_hydro_15; pfam00723
633149002076	alpha,alpha-trehalose-phosphate synthase [UDP-forming]; Region: trehalose_OtsA; TIGR02400
633149002077	Trehalose-6-Phosphate Synthase (TPS) is a glycosyltransferase that catalyses the synthesis of alpha,alpha-1,1-trehalose-6-phosphate from glucose-6-phosphate using a UDP-glucose donor. It is a key enzyme in the trehalose synthesis pathway. Trehalose is a...; Region: GT1_TPS; cd03788
633149002078	active site
633149002079	homotetramer interface [polypeptide binding]; other site
633149002080	Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625
633149002081	GST_N family, Saccharomyces cerevisiae GTT1-like subfamily; composed of predominantly uncharacterized proteins with similarity to the S. cerevisiae GST protein, GTT1, and the Schizosaccharomyces pombe GST-III. GSTs are cytosolic dimeric proteins involved...; Region: GST_N_GTT1_like; cd03046
633149002082	putative C-terminal domain interface [polypeptide binding]; other site
633149002083	putative GSH binding site (G-site) [chemical binding]; other site
633149002084	putative dimer interface [polypeptide binding]; other site
633149002085	C-terminal, alpha helical domain of an unknown subfamily 8 of Glutathione S-transferases; Region: GST_C_8; cd03207
633149002086	dimer interface [polypeptide binding]; other site
633149002087	N-terminal domain interface [polypeptide binding]; other site
633149002088	putative substrate binding pocket (H-site) [chemical binding]; other site
633149002089	Predicted transcriptional regulator [Transcription]; Region: COG2378
633149002090	HTH domain; Region: HTH_11; pfam08279
633149002091	WYL domain; Region: WYL; pfam13280
633149002092	acetyl-CoA acetyltransferase; Provisional; Region: PRK07108
633149002093	Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751
633149002094	dimer interface [polypeptide binding]; other site
633149002095	active site
633149002096	(3R)-hydroxyacyl-CoA dehydrogenase-like, classical(c)-like SDRs; Region: hydroxyacyl-CoA-like_DH_SDR_c-like; cd05353
633149002097	NAD binding site [chemical binding]; other site
633149002098	homodimer interface [polypeptide binding]; other site
633149002099	active site
633149002100	Opacity protein and related surface antigens [Cell envelope biogenesis, outer membrane]; Region: COG3637
633149002101	Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885
633149002102	Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185
633149002103	ligand binding site [chemical binding]; other site
633149002104	Capsule polysaccharide export protein [Cell envelope biogenesis, outer membrane]; Region: KpsS; COG3562
633149002105	Capsule polysaccharide biosynthesis protein; Region: Capsule_synth; pfam05159
633149002106	aminotransferase, LLPSF_NHT_00031 family; Region: NHT_00031; TIGR04181
633149002107	Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321
633149002108	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
633149002109	catalytic residue [active]
633149002110	Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885
633149002111	Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185
633149002112	ligand binding site [chemical binding]; other site
633149002113	Isopenicillin N synthase and related dioxygenases [General function prediction only]; Region: PcbC; COG3491
633149002114	non-haem dioxygenase in morphine synthesis N-terminal; Region: DIOX_N; pfam14226
633149002115	2OG-Fe(II) oxygenase superfamily; Region: 2OG-FeII_Oxy; pfam03171
633149002116	NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, subunit 9, 39 kDa, (NDUFA9) -like, atypical (a) SDRs; Region: NDUFA9_like_SDR_a; cd05271
633149002117	NAD dependent epimerase/dehydratase family; Region: Epimerase; pfam01370
633149002118	putative NAD(P) binding site [chemical binding]; other site
633149002119	active site
633149002120	Ribonuclease D [Translation, ribosomal structure and biogenesis]; Region: Rnd; COG0349
633149002121	DEDDy 3'-5' exonuclease domain of Ribonuclease D and similar proteins; Region: RNaseD_exo; cd06142
633149002122	catalytic site [active]
633149002123	putative active site [active]
633149002124	putative substrate binding site [chemical binding]; other site
633149002125	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5375
633149002126	lipopolysaccharide transport periplasmic protein LptA; Region: outer_YhbN_LptA; TIGR03002
633149002127	OstA-like protein; Region: OstA; cl00844
633149002128	ABC-type (unclassified) transport system, ATPase component [General function prediction only]; Region: YhbG; COG1137
633149002129	ATP-binding cassette component of YhbG transport system; Region: ABC_YhbG; cd03218
633149002130	Walker A/P-loop; other site
633149002131	ATP binding site [chemical binding]; other site
633149002132	Q-loop/lid; other site
633149002133	ABC transporter signature motif; other site
633149002134	Walker B; other site
633149002135	D-loop; other site
633149002136	H-loop/switch region; other site
633149002137	Predicted membrane protein [Function unknown]; Region: COG1971
633149002138	Domain of unknown function DUF; Region: DUF204; pfam02659
633149002139	Domain of unknown function DUF; Region: DUF204; pfam02659
633149002140	progesterone 5-beta-reductase-like proteins (5beta-POR), atypical (a) SDRs; Region: 5beta-POR_like_SDR_a; cd08948
633149002141	NAD(P) binding site [chemical binding]; other site
633149002142	active site
633149002143	The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530
633149002144	Catalytic site [active]
633149002145	Signal peptidase, peptidase S26; Region: Peptidase_S26; pfam10502
633149002146	The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530
633149002147	Protein of unknown function (DUF805); Region: DUF805; pfam05656
633149002148	RNA polymerase factor sigma-54; Reviewed; Region: PRK05932
633149002149	Sigma-54 factor, Activator interacting domain (AID); Region: Sigma54_AID; pfam00309
633149002150	Sigma-54 factor, core binding domain; Region: Sigma54_CBD; pfam04963
633149002151	Sigma-54, DNA binding domain; Region: Sigma54_DBD; pfam04552
633149002152	RaiA ("ribosome-associated inhibitor A", also known as Protein Y (PY), YfiA, and SpotY,  is a stress-response protein that binds the ribosomal subunit interface and arrests translation by interfering with aminoacyl-tRNA binding to the ribosomal...; Region: RaiA; cd00552
633149002153	30S subunit binding site; other site
633149002154	PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211
633149002155	active site
633149002156	phosphorylation site [posttranslational modification]
633149002157	Protein of unknown function (DUF1150); Region: DUF1150; pfam06620
633149002158	Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071
633149002159	Alpha-crystallin domain (ACD) found in Escherichia coli inclusion body-associated proteins IbpA and IbpB, and similar proteins.  IbpA and IbpB are 16 kDa small heat shock proteins (sHsps). sHsps are molecular chaperones that suppress protein aggregation...; Region: ACD_IbpA-B_like; cd06470
633149002160	putative dimer interface [polypeptide binding]; other site
633149002161	Protein of unknown function (FYDLN_acid); Region: FYDLN_acid; pfam09538
633149002162	TIGR02300 family protein; Region: FYDLN_acid
633149002163	3-phosphoshikimate 1-carboxyvinyltransferase; Provisional; Region: PRK02427
633149002164	EPSP synthase domain. 3-phosphoshikimate 1-carboxyvinyltransferase (5-enolpyruvylshikimate-3-phosphate synthase) (EC 2.5.1.19) catalyses the reaction between shikimate-3-phosphate (S3P) and phosphoenolpyruvate (PEP) to form...; Region: EPSP_synthase; cd01556
633149002165	hinge; other site
633149002166	active site
633149002167	Cytidylate kinase [Nucleotide transport and metabolism]; Region: Cmk; COG0283
633149002168	Cytidine monophosphate kinase (CMPK) catalyzes the reversible phosphorylation of cytidine monophosphate (CMP) to produce cytidine diphosphate (CDP), using ATP as the preferred phosphoryl donor; Region: CMPK; cd02020
633149002169	CMP-binding site; other site
633149002170	The sites determining sugar specificity; other site
633149002171	30S ribosomal protein S1; Reviewed; Region: rpsA; PRK06299
633149002172	S1_RPS1_repeat_ec1_hs1: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec1_hs1; cd05687
633149002173	RNA binding site [nucleotide binding]; other site
633149002174	S1_RPS1_repeat_ec2_hs2: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec2_hs2; cd04465
633149002175	RNA binding site [nucleotide binding]; other site
633149002176	S1_RPS1_repeat_ec3: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec3; cd05688
633149002177	RNA binding site [nucleotide binding]; other site
633149002178	S1_RPS1_repeat_ec4: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec4; cd05689
633149002179	RNA binding site [nucleotide binding]; other site
633149002180	S1_RPS1_repeat_ec5: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec5; cd05690
633149002181	RNA binding site [nucleotide binding]; other site
633149002182	S1_RPS1_repeat_ec6: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec6; cd05691
633149002183	RNA binding site [nucleotide binding]; other site
633149002184	Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591
633149002185	IHF dimer interface [polypeptide binding]; other site
633149002186	IHF - DNA interface [nucleotide binding]; other site
633149002187	large-conductance mechanosensitive channel; Provisional; Region: mscL; PRK13952
633149002188	large-conductance mechanosensitive channel; Reviewed; Region: mscL; PRK00567
633149002189	Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673
633149002190	POT family; Region: PTR2; cl17359
633149002191	POT family; Region: PTR2; cl17359
633149002192	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244
633149002193	Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629
633149002194	Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629
633149002195	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244
633149002196	TraB family; Region: TraB; pfam01963
633149002197	Predicted Zn-dependent proteases and their inactivated homologs [General function prediction only]; Region: TldD; COG0312
633149002198	Protein of unknown function (DUF2807); Region: DUF2807; pfam10988
633149002199	Predicted membrane protein [Function unknown]; Region: COG4709
633149002200	Predicted transcriptional regulators [Transcription]; Region: COG1695
633149002201	Transcriptional regulator PadR-like family; Region: PadR; pfam03551
633149002202	Cytochrome C oxidase subunit II, transmembrane domain; Region: COX2_TM; pfam02790
633149002203	cytochrome c oxidase subunit II; Provisional; Region: COX2; MTH00168
633149002204	Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; pfam00116
633149002205	Heme/copper-type cytochrome/quinol oxidases, subunit 1 [Energy production and conversion]; Region: CyoB; COG0843
633149002206	Cytochrome C oxidase subunit I.  Cytochrome c oxidase (CcO), the terminal oxidase in the respiratory chains of eukaryotes and most bacteria, is a multi-chain transmembrane protein located in the inner membrane of mitochondria and the cell membrane of...; Region: Cyt_c_Oxidase_I; cd01663
633149002207	Subunit I/III interface [polypeptide binding]; other site
633149002208	D-pathway; other site
633149002209	Subunit I/VIIc interface [polypeptide binding]; other site
633149002210	Subunit I/IV interface [polypeptide binding]; other site
633149002211	Subunit I/II interface [polypeptide binding]; other site
633149002212	Low-spin heme (heme a) binding site [chemical binding]; other site
633149002213	Subunit I/VIIa interface [polypeptide binding]; other site
633149002214	Subunit I/VIa interface [polypeptide binding]; other site
633149002215	Dimer interface; other site
633149002216	Putative water exit pathway; other site
633149002217	Binuclear center (heme a3/CuB) [ion binding]; other site
633149002218	K-pathway; other site
633149002219	Subunit I/Vb interface [polypeptide binding]; other site
633149002220	Putative proton exit pathway; other site
633149002221	Subunit I/VIb interface; other site
633149002222	Subunit I/VIc interface [polypeptide binding]; other site
633149002223	Electron transfer pathway; other site
633149002224	Subunit I/VIIIb interface [polypeptide binding]; other site
633149002225	Subunit I/VIIb interface [polypeptide binding]; other site
633149002226	protoheme IX farnesyltransferase; Provisional; Region: PRK04375
633149002227	UbiA prenyltransferase family; Region: UbiA; pfam01040
633149002228	cytochrome C oxidase assembly protein; Provisional; Region: PRK05089
633149002229	Cytochrome c oxidase subunit III.  Cytochrome c oxidase (CcO), the terminal oxidase in the respiratory chains of eukaryotes and most bacteria, is a multi-chain transmembrane protein located in the inner membrane of mitochondria and the cell membrane of...; Region: Cyt_c_Oxidase_III; cd01665
633149002230	Subunit III/VIIa interface [polypeptide binding]; other site
633149002231	Phospholipid binding site [chemical binding]; other site
633149002232	Subunit I/III interface [polypeptide binding]; other site
633149002233	Subunit III/VIb interface [polypeptide binding]; other site
633149002234	Subunit III/VIa interface; other site
633149002235	Subunit III/Vb interface [polypeptide binding]; other site
633149002236	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5349
633149002237	SURF1 superfamily. Surf1/Shy1 has been implicated in the posttranslational steps of the biogenesis of the mitochondrially-encoded Cox1 subunit of cytochrome c oxidase (complex IV). Cytochrome c oxidase (complex IV), the terminal electron-transferring...; Region: SURF1; cd06662
633149002238	Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612
633149002239	Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675
633149002240	Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193
633149002241	Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302
633149002242	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182
633149002243	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
633149002244	metal binding site [ion binding]; metal-binding site
633149002245	active site
633149002246	I-site; other site
633149002247	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
633149002248	Uncharacterized ACR, COG1678; Region: DUF179; cl00731
633149002249	Peroxiredoxin (PRX) family, PRX5-like subfamily; members are similar to the human protein, PRX5, a homodimeric TRX peroxidase, widely expressed in tissues and found cellularly in mitochondria, peroxisomes and the cytosol. The cellular location of PRX5...; Region: PRX5_like; cd03013
633149002250	catalytic triad [active]
633149002251	dimer interface [polypeptide binding]; other site
633149002252	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
633149002253	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
633149002254	dimer interface [polypeptide binding]; other site
633149002255	phosphorylation site [posttranslational modification]
633149002256	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
633149002257	ATP binding site [chemical binding]; other site
633149002258	Mg2+ binding site [ion binding]; other site
633149002259	G-X-G motif; other site
633149002260	Response regulator receiver domain; Region: Response_reg; pfam00072
633149002261	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
633149002262	active site
633149002263	phosphorylation site [posttranslational modification]
633149002264	intermolecular recognition site; other site
633149002265	dimerization interface [polypeptide binding]; other site
633149002266	dihydroorotate dehydrogenase 2; Reviewed; Region: PRK05286
633149002267	Dihydroorotate dehydrogenase (DHOD) class 2. DHOD catalyzes the oxidation of (S)-dihydroorotate to orotate. This is the fourth step and the only redox reaction in the de novo biosynthesis of UMP, the precursor of all pyrimidine nucleotides. DHOD requires...; Region: DHOD_2_like; cd04738
633149002268	quinone interaction residues [chemical binding]; other site
633149002269	active site
633149002270	catalytic residues [active]
633149002271	FMN binding site [chemical binding]; other site
633149002272	substrate binding site [chemical binding]; other site
633149002273	Protein of unknown function (DUF952); Region: DUF952; pfam06108
633149002274	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
633149002275	catalytic core [active]
633149002276	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173
633149002277	Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446
633149002278	acetoacetyl-CoA reductase; Region: AcAcCoA_reduct; TIGR01829
633149002279	beta-Keto acyl carrier protein reductase (BKR), involved in Type II FAS, classical (c) SDRs; Region: BKR_SDR_c; cd05333
633149002280	NAD(P) binding site [chemical binding]; other site
633149002281	homotetramer interface [polypeptide binding]; other site
633149002282	homodimer interface [polypeptide binding]; other site
633149002283	active site
633149002284	Zn-dependent alcohol dehydrogenases [General function prediction only]; Region: AdhP; COG1064
633149002285	Cinnamyl alcohol dehydrogenases (CAD); Region: CAD1; cd05283
633149002286	putative NAD(P) binding site [chemical binding]; other site
633149002287	putative substrate binding site [chemical binding]; other site
633149002288	catalytic Zn binding site [ion binding]; other site
633149002289	structural Zn binding site [ion binding]; other site
633149002290	dimer interface [polypeptide binding]; other site
633149002291	Protein of unknown function DUF72; Region: DUF72; pfam01904
633149002292	Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885
633149002293	Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185
633149002294	ligand binding site [chemical binding]; other site
633149002295	glutamate--cysteine ligase; Region: PLN02611
633149002296	16S ribosomal RNA methyltransferase RsmE; Provisional; Region: PRK11713
633149002297	RNA methyltransferase, RsmE family; Region: TIGR00046
633149002298	GIY-YIG domain of uncharacterized hypothetical protein found in bacteria; Region: GIY-YIG_unchar_3; cd10448
633149002299	GIY-YIG motif/motif A; other site
633149002300	putative active site [active]
633149002301	putative metal binding site [ion binding]; other site
633149002302	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
633149002303	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
633149002304	active site
633149002305	Acyl-CoA dehydrogenase N terminal; Region: AcylCoA_DH_N; pfam12418
633149002306	acyl-CoA dehydrogenase; Provisional; Region: PTZ00456
633149002307	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
633149002308	active site
633149002309	Acetyl-CoA dehydrogenase C-terminal like; Region: Acyl-CoA_dh_C; pfam12806
633149002310	Helix-Turn-Helix DNA binding domain of the regulatory protein GnyR; Region: HTH_GnyR; cd04776
633149002311	MerR HTH family regulatory protein; Region: MerR_1; pfam13411
633149002312	DNA binding residues [nucleotide binding]
633149002313	putative dimer interface [polypeptide binding]; other site
633149002314	Uncharacterized protein conserved in bacteria (DUF2256); Region: DUF2256; pfam10013
633149002315	DoxX-like family; Region: DoxX_2; pfam13564
633149002316	hypothetical protein; Validated; Region: PRK00029
633149002317	Uncharacterized conserved protein [Function unknown]; Region: COG0397
633149002318	Na+/H+ antiporter 1; Region: Na_H_antiport_1; cl01133
633149002319	Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629
633149002320	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244
633149002321	TonB dependent receptor; Region: TonB_dep_Rec; pfam00593
633149002322	Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841
633149002323	RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730
633149002324	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
633149002325	HlyD family secretion protein; Region: HlyD_3; pfam13437
633149002326	GTP-binding protein LepA; Provisional; Region: PRK05433
633149002327	LepA also known as Elongation Factor 4 (EF4); Region: LepA; cd01890
633149002328	G1 box; other site
633149002329	putative GEF interaction site [polypeptide binding]; other site
633149002330	GTP/Mg2+ binding site [chemical binding]; other site
633149002331	Switch I region; other site
633149002332	G2 box; other site
633149002333	G3 box; other site
633149002334	Switch II region; other site
633149002335	G4 box; other site
633149002336	G5 box; other site
633149002337	lepA_II: This subfamily represents the domain II of LepA, a GTP-binding protein localized in the cytoplasmic membrane. The N-terminal domain of LepA shares regions of homology to translation factors. In terms of interaction with the ribosome, EF-G, EF-Tu...; Region: lepA_II; cd03699
633149002338	lepA_C: This family represents the C-terminal region of LepA, a GTP-binding protein localized in the cytoplasmic membrane.   LepA is ubiquitous in Bacteria and Eukaryota (e.g. Saccharomyces cerevisiae GUF1p), but is missing from Archaea. LepA exhibits...; Region: lepA_C; cd03709
633149002339	GTP-binding protein LepA C-terminus; Region: LepA_C; pfam06421
633149002340	Domain of unknown function (DUF3883); Region: DUF3883; pfam13020
633149002341	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
633149002342	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
633149002343	dimer interface [polypeptide binding]; other site
633149002344	phosphorylation site [posttranslational modification]
633149002345	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
633149002346	ATP binding site [chemical binding]; other site
633149002347	Mg2+ binding site [ion binding]; other site
633149002348	G-X-G motif; other site
633149002349	Response regulator receiver domain; Region: Response_reg; pfam00072
633149002350	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
633149002351	active site
633149002352	phosphorylation site [posttranslational modification]
633149002353	intermolecular recognition site; other site
633149002354	dimerization interface [polypeptide binding]; other site
633149002355	efflux pump membrane protein (multidrug resistance protein A); Region: 8a0101; TIGR00998
633149002356	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
633149002357	Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849
633149002358	E3 interaction surface; other site
633149002359	lipoyl attachment site [posttranslational modification]; other site
633149002360	drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711
633149002361	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
633149002362	Uncharacterized protein related to the periplasmic component of the Tol biopolymer transport system [Function unknown]; Region: COG4946
633149002363	WD40-like Beta Propeller Repeat; Region: PD40; pfam07676
633149002364	WD40-like Beta Propeller Repeat; Region: PD40; pfam07676
633149002365	WD40-like Beta Propeller Repeat; Region: PD40; pfam07676
633149002366	C-terminal processing peptidase family S41; Region: Peptidase_S41; cl02526
633149002367	PDZ domain, also called DHR (Dlg homologous region) or GLGF (after a conserved sequence motif). Many PDZ domains bind C-terminal polypeptides, though binding to internal (non-C-terminal) polypeptides and even to lipids has been demonstrated; Region: PDZ; cl00117
633149002368	protein binding site [polypeptide binding]; other site
633149002369	Tricorn protease; serine protease family S41; Region: Peptidase_S41_TRI; cd07562
633149002370	Domain interface; other site
633149002371	Peptide binding site; other site
633149002372	Active site tetrad [active]
633149002373	YcxB-like protein; Region: YcxB; pfam14317
633149002374	Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885
633149002375	Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185
633149002376	ligand binding site [chemical binding]; other site
633149002377	Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612
633149002378	Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675
633149002379	Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193
633149002380	Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612
633149002381	Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675
633149002382	Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193
633149002383	2-keto-3-deoxy-6-phosphogluconate aldolase [Carbohydrate transport and metabolism]; Region: Eda; COG0800
633149002384	KDPG and KHG aldolase; Region: KDPG_aldolase; cd00452
633149002385	active site
633149002386	intersubunit interface [polypeptide binding]; other site
633149002387	catalytic residue [active]
633149002388	Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487
633149002389	active site
633149002390	catalytic residues [active]
633149002391	metal binding site [ion binding]; metal-binding site
633149002392	4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586
633149002393	active site
633149002394	MotA/TolQ/ExbB proton channel family; Region: MotA_ExbB; cl00568
633149002395	Biopolymer transport protein [Intracellular trafficking and secretion]; Region: ExbD; COG0848
633149002396	TolR protein; Region: tolR; TIGR02801
633149002397	translocation protein TolB; Provisional; Region: tolB; PRK05137
633149002398	TolB amino-terminal domain; Region: TolB_N; pfam04052
633149002399	WD40-like Beta Propeller Repeat; Region: PD40; pfam07676
633149002400	WD40-like Beta Propeller Repeat; Region: PD40; pfam07676
633149002401	WD40-like Beta Propeller Repeat; Region: PD40; pfam07676
633149002402	WD40-like Beta Propeller Repeat; Region: PD40; pfam07676
633149002403	Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885
633149002404	Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185
633149002405	ligand binding site [chemical binding]; other site
633149002406	Double zinc ribbon; Region: DZR; pfam12773
633149002407	zinc-ribbon domain; Region: zf-ribbon_3; pfam13248
633149002408	Protein of unknown function (DUF3667); Region: DUF3667; pfam12412
633149002409	tol-pal system protein YbgF; Region: tol_pal_ybgF; TIGR02795
633149002410	N-terminal domain of predicted ATPase of the PP-loop faimly implicated in cell cycle control [Cell division and chromosome partitioning]. This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases...; Region: PP-ATPase; cd01992
633149002411	tRNA(Ile)-lysidine synthase MesJ [Cell cycle control, cell division, chromosome partitioning]; Region: MesJ; COG0037
633149002412	FtsH Extracellular; Region: FtsH_ext; pfam06480
633149002413	ATP-dependent metalloprotease FtsH; Region: FtsH_fam; TIGR01241
633149002414	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
633149002415	Walker A motif; other site
633149002416	ATP binding site [chemical binding]; other site
633149002417	Walker B motif; other site
633149002418	arginine finger; other site
633149002419	Peptidase family M41; Region: Peptidase_M41; pfam01434
633149002420	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4430
633149002421	Bacteriocin-protection, YdeI or OmpD-Associated; Region: OmdA; pfam13376
633149002422	DHPS subgroup of Pterin binding enzymes. DHPS (dihydropteroate synthase), a functional homodimer, catalyzes the condensation of p-aminobenzoic acid (pABA) in the de novo biosynthesis of folate, which is an essential cofactor in both nucleic acid and...; Region: DHPS; cd00739
633149002423	dihydropteroate synthase; Region: DHPS; TIGR01496
633149002424	substrate binding pocket [chemical binding]; other site
633149002425	dimer interface [polypeptide binding]; other site
633149002426	inhibitor binding site; inhibition site
633149002427	4-amino-5-hydroxymethyl-2-methyl-pyrimidine phosphate kinase (HMPP-kinase) catalyzes two consecutive phosphorylation steps in the thiamine phosphate biosynthesis pathway, leading to the synthesis of vitamin B1. The first step is the phosphorylation of...; Region: HMPP_kinase; cd01169
633149002428	dimer interface [polypeptide binding]; other site
633149002429	substrate binding site [chemical binding]; other site
633149002430	ATP binding site [chemical binding]; other site
633149002431	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3575
633149002432	Predicted epimerase, PhzC/PhzF homolog [General function prediction only]; Region: COG0384
633149002433	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
633149002434	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
633149002435	active site
633149002436	phosphorylation site [posttranslational modification]
633149002437	intermolecular recognition site; other site
633149002438	dimerization interface [polypeptide binding]; other site
633149002439	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
633149002440	DNA binding site [nucleotide binding]
633149002441	heavy metal sensor kinase; Region: cztS_silS_copS; TIGR01386
633149002442	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
633149002443	ATP binding site [chemical binding]; other site
633149002444	Mg2+ binding site [ion binding]; other site
633149002445	G-X-G motif; other site
633149002446	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
633149002447	binding surface
633149002448	TPR repeat; Region: TPR_11; pfam13414
633149002449	TPR motif; other site
633149002450	cytochrome c-type biogenesis protein CcmE; Reviewed; Region: PRK13254
633149002451	Cytochrome c biogenesis factor [Posttranslational modification, protein turnover, chaperones]; Region: CcmF; COG1138
633149002452	Cytochrome C biogenesis protein; Region: CcmH; pfam03918
633149002453	periplasmic serine protease, Do/DeqQ family; Region: degP_htrA_DO; TIGR02037
633149002454	Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365
633149002455	PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987
633149002456	protein binding site [polypeptide binding]; other site
633149002457	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
633149002458	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
633149002459	active site
633149002460	phosphorylation site [posttranslational modification]
633149002461	intermolecular recognition site; other site
633149002462	dimerization interface [polypeptide binding]; other site
633149002463	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
633149002464	DNA binding site [nucleotide binding]
633149002465	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
633149002466	dimerization interface [polypeptide binding]; other site
633149002467	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
633149002468	dimer interface [polypeptide binding]; other site
633149002469	phosphorylation site [posttranslational modification]
633149002470	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
633149002471	ATP binding site [chemical binding]; other site
633149002472	Mg2+ binding site [ion binding]; other site
633149002473	G-X-G motif; other site
633149002474	bifunctional glutamine-synthetase adenylyltransferase/deadenyltransferase; Provisional; Region: PRK14108
633149002475	Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401
633149002476	metal binding triad; other site
633149002477	GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335
633149002478	Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401
633149002479	metal binding triad; other site
633149002480	Arsenate Reductase (ArsC) family, ArsC subfamily; arsenic reductases similar to that encoded by arsC on the R733 plasmid of Escherichia coli. E. coli ArsC catalyzes the reduction of arsenate [As(V)] to arsenite [As(III)], the first step in the...; Region: ArsC_ArsC; cd03034
633149002481	ArsC family; Region: ArsC; pfam03960
633149002482	catalytic residues [active]
633149002483	EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to...; Region: EFh; cl17302
633149002484	pseudo EF-hand loop; other site
633149002485	EF-hand domain pair; Region: EF_hand_5; pfam13499
633149002486	peptide binding pocket; other site
633149002487	Ca2+ binding site [ion binding]; other site
633149002488	RNA polymerase sigma factor; Reviewed; Region: PRK05602
633149002489	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
633149002490	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
633149002491	DNA binding residues [nucleotide binding]
633149002492	PAS domain; Region: PAS; smart00091
633149002493	PAS fold; Region: PAS; pfam00989
633149002494	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
633149002495	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
633149002496	dimer interface [polypeptide binding]; other site
633149002497	phosphorylation site [posttranslational modification]
633149002498	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
633149002499	ATP binding site [chemical binding]; other site
633149002500	Mg2+ binding site [ion binding]; other site
633149002501	G-X-G motif; other site
633149002502	FOG: CBS domain [General function prediction only]; Region: COG0517
633149002503	The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair_9; cd04622
633149002504	NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961
633149002505	Aldehyde dehydrogenase family; Region: Aldedh; pfam00171
633149002506	NAD(P) binding site [chemical binding]; other site
633149002507	catalytic residues [active]
633149002508	Bacterial aspartate proteases, retropepsin-like protease family; Region: retropepsin_like_bacteria; cd05483
633149002509	catalytic motif [active]
633149002510	Catalytic residue [active]
633149002511	Bacterial aspartate proteases, retropepsin-like protease family; Region: retropepsin_like_bacteria; cd05483
633149002512	catalytic motif [active]
633149002513	Catalytic residue [active]
633149002514	Gamma-glutamyl phosphate reductase (GPR), aldehyde dehydrogenase families 18 and 19; Region: ALDH_F18-19_ProA-GPR; cd07079
633149002515	gamma-glutamyl phosphate reductase; Region: proA; TIGR00407
633149002516	putative catalytic cysteine [active]
633149002517	gamma-glutamyl kinase; Provisional; Region: PRK05429
633149002518	AAK_G5K_ProB: Glutamate-5-kinase (G5K) catalyzes glutamate-dependent ATP cleavage; G5K transfers the terminal phosphoryl group of ATP to the gamma-carboxyl group of glutamate, in the first and controlling step of proline (and, in mammals, ornithine)...; Region: AAK_G5K_ProB; cd04242
633149002519	nucleotide binding site [chemical binding]; other site
633149002520	homotetrameric interface [polypeptide binding]; other site
633149002521	putative phosphate binding site [ion binding]; other site
633149002522	putative allosteric binding site; other site
633149002523	PUA domain; Region: PUA; pfam01472
633149002524	Predicted metalloprotease [General function prediction only]; Region: COG2321
633149002525	Putative neutral zinc metallopeptidase; Region: Zn_peptidase; pfam04228
633149002526	A type 1 glutamine amidotransferase (GATase1)-like domain found in PfpI from Pyrococcus furiosus; Region: GATase1_PfpI_like; cd03134
633149002527	intracellular protease, PfpI family; Region: PfpI; TIGR01382
633149002528	proposed catalytic triad [active]
633149002529	conserved cys residue [active]
633149002530	Predicted methyltransferase [General function prediction only]; Region: COG3897
633149002531	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173
633149002532	Predicted unusual protein kinase [General function prediction only]; Region: AarF; COG0661
633149002533	ABC1 family; Region: ABC1; pfam03109
633149002534	Putative rhamnosyl transferase; Region: Rhamno_transf; pfam11316
633149002535	Peptidase Gluzincin family (thermolysin-like proteinases, TLPs) includes peptidases M1, M2, M3, M4, M13, M32 and M36 (fungalysins); Region: GluZincin; cl14813
633149002536	Zn binding site [ion binding]; other site
633149002537	Protein of unknown function (DUF1311); Region: DUF1311; pfam07007
633149002538	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
633149002539	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
633149002540	non-specific DNA binding site [nucleotide binding]; other site
633149002541	salt bridge; other site
633149002542	sequence-specific DNA binding site [nucleotide binding]; other site
633149002543	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
633149002544	Domain of unknown function (DUF4163); Region: DUF4163; pfam13739
633149002545	Protein of unknown function (DUF3298); Region: DUF3298; pfam11738
633149002546	4-hydroxybenzoate polyprenyltransferase; Reviewed; Region: ubiA; PRK12878
633149002547	UbiA prenyltransferase family; Region: UbiA; pfam01040
633149002548	Protein of unknown function, DUF417; Region: DUF417; cl01162
633149002549	Protein of unknown function, DUF606; Region: DUF606; pfam04657
633149002550	Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_21; cd04680
633149002551	nudix motif; other site
633149002552	short chain dehydrogenase; Provisional; Region: PRK09134
633149002553	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
633149002554	NAD(P) binding site [chemical binding]; other site
633149002555	active site
633149002556	Dihydroneopterin aldolase; Region: FolB; smart00905
633149002557	active site
633149002558	pimeloyl-CoA dehydrogenase, small subunit; Region: pimD_small; TIGR03203
633149002559	Acyl-CoA dehydrogenase, N-terminal domain; Region: Acyl-CoA_dh_N; pfam02771
633149002560	Acyl-CoA dehydrogenase; Region: ACAD; cd00567
633149002561	active site
633149002562	pimeloyl-CoA dehydrogenase, large subunit; Region: pimC_large; TIGR03204
633149002563	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
633149002564	active site
633149002565	Transcriptional regulators [Transcription]; Region: Lrp; COG1522
633149002566	AsnC family; Region: AsnC_trans_reg; pfam01037
633149002567	Esterases and lipases (includes fungal lipases, cholinesterases, etc.)  These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312
633149002568	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
633149002569	substrate binding pocket [chemical binding]; other site
633149002570	Escherichia coli exonuclease III (ExoIII) and Neisseria meningitides NExo-like subfamily of the ExoIII family purinic/apyrimidinic (AP) endonucleases; Region: ExoIII-like_AP-endo; cd09086
633149002571	putative catalytic site [active]
633149002572	putative phosphate binding site [ion binding]; other site
633149002573	active site
633149002574	metal binding site A [ion binding]; metal-binding site
633149002575	DNA binding site [nucleotide binding]
633149002576	putative AP binding site [nucleotide binding]; other site
633149002577	putative metal binding site B [ion binding]; other site
633149002578	Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; COG0475
633149002579	Sodium/hydrogen exchanger family; Region: Na_H_Exchanger; pfam00999
633149002580	Kef-type K+ transport systems, predicted NAD-binding component [Inorganic ion transport and metabolism]; Region: Kch; COG1226
633149002581	TrkA-N domain; Region: TrkA_N; pfam02254
633149002582	Domain of unknown function (DUF4126); Region: DUF4126; pfam13548
633149002583	short chain dehydrogenase; Provisional; Region: PRK06701
633149002584	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
633149002585	NAD(P) binding site [chemical binding]; other site
633149002586	active site
633149002587	Predicted acetyltransferase [General function prediction only]; Region: COG2388
633149002588	Predicted membrane protein [Function unknown]; Region: COG3671
633149002589	Tunnelling fold (T-fold). The five known T-folds are found in five different enzymes with different functions: dihydroneopterin-triphosphate epimerase (DHNTPE), dihydroneopterin aldolase (DHNA) , GTP cyclohydrolase I (GTPCH-1),  6-pyrovoyl...; Region: TFold; cl00263
633149002590	homogentisate 1,2-dioxygenase; Provisional; Region: PRK05341
633149002591	Co/Zn/Cd efflux system component [Inorganic ion transport and metabolism]; Region: CzcD; COG1230
633149002592	alpha/beta hydrolase fold; Region: Abhydrolase_1; pfam00561
633149002593	TAP-like protein; Region: Abhydrolase_4; pfam08386
633149002594	Cyclopropane fatty acid synthase and related methyltransferases [Cell envelope biogenesis, outer membrane]; Region: Cfa; COG2230
633149002595	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
633149002596	S-adenosylmethionine binding site [chemical binding]; other site
633149002597	50S ribosomal protein L21/unknown domain fusion protein; Provisional; Region: PRK12278
633149002598	50S ribosomal protein L21; Validated; Region: rplU; PRK05573
633149002599	50S ribosomal protein L27; Validated; Region: rpmA; PRK05435
633149002600	Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302
633149002601	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182
633149002602	threonine dehydratase; Provisional; Region: PRK07334
633149002603	Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562
633149002604	tetramer interface [polypeptide binding]; other site
633149002605	pyridoxal 5'-phosphate binding site [chemical binding]; other site
633149002606	catalytic residue [active]
633149002607	C-terminal ACT domain of biodegradative (catabolic) threonine dehydratase II (ThrD-II) and other related ACT domains; Region: ACT_ThrD-II-like; cd04886
633149002608	FKBP-type peptidyl-prolyl cis-trans isomerases 1 [Posttranslational modification, protein turnover, chaperones]; Region: FkpA; COG0545
633149002609	Domain amino terminal to FKBP-type peptidyl-prolyl isomerase; Region: FKBP_N; pfam01346
633149002610	FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254
633149002611	Dam-replacing family; Region: DRP; pfam06044
633149002612	AAA domain; Region: AAA_21; pfam13304
633149002613	RloB-like protein; Region: RloB; pfam13707
633149002614	excinuclease ABC subunit B; Provisional; Region: PRK05298
633149002615	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
633149002616	ATP binding site [chemical binding]; other site
633149002617	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
633149002618	nucleotide binding region [chemical binding]; other site
633149002619	ATP-binding site [chemical binding]; other site
633149002620	Ultra-violet resistance protein B; Region: UvrB; pfam12344
633149002621	Extensin-like protein C-terminus; Region: Extensin-like_C; pfam06904
633149002622	Peptidase M14-like domain; uncharacterized subgroup; Region: M14-like_1_1; cd06238
633149002623	putative active site [active]
633149002624	Zn binding site [ion binding]; other site
633149002625	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
633149002626	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
633149002627	non-specific DNA binding site [nucleotide binding]; other site
633149002628	salt bridge; other site
633149002629	sequence-specific DNA binding site [nucleotide binding]; other site
633149002630	Predicted transcriptional regulators [Transcription]; Region: COG1695
633149002631	Transcriptional regulator PadR-like family; Region: PadR; cl17335
633149002632	Adenosine deaminase [Nucleotide transport and metabolism]; Region: Ada; COG2169
633149002633	Metal binding domain of Ada; Region: Ada_Zn_binding; pfam02805
633149002634	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
633149002635	AlkA N-terminal domain; Region: AlkA_N; pfam06029
633149002636	Methylated DNA-protein cysteine methyltransferase [DNA replication, recombination, and repair]; Region: Ada; COG0350
633149002637	The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445
633149002638	DNA binding site [nucleotide binding]
633149002639	active site
633149002640	threonine dehydratase; Reviewed; Region: PRK09224
633149002641	Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562
633149002642	tetramer interface [polypeptide binding]; other site
633149002643	pyridoxal 5'-phosphate binding site [chemical binding]; other site
633149002644	catalytic residue [active]
633149002645	ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141
633149002646	Second of two tandem C-terminal ACT domains of threonine dehydratase I (ThrD-I; L-threonine hydrolyase); Region: ACT_ThrD-I_2; cd04907
633149002647	putative Ile/Val binding site [chemical binding]; other site
633149002648	quinolinate synthetase; Provisional; Region: PRK09375
633149002649	Site-2 protease (S2P) class of zinc metalloproteases (MEROPS family M50) cleaves transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of this family use proteolytic...; Region: S2P-M50; cl10020
633149002650	Peptidase family M50; Region: Peptidase_M50; pfam02163
633149002651	active site
633149002652	putative substrate binding region [chemical binding]; other site
633149002653	L-aspartate oxidase; Provisional; Region: PRK07512
633149002654	L-aspartate oxidase; Provisional; Region: PRK06175
633149002655	Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910
633149002656	Nicotinate-nucleotide pyrophosphorylase [Coenzyme metabolism]; Region: NadC; COG0157
633149002657	Quinolinate phosphoribosyl transferase (QAPRTase or QPRTase), also called nicotinate-nucleotide pyrophosphorylase, is involved in the de novo synthesis of NAD in both prokaryotes and eukaryotes. It catalyses the reaction of quinolinic acid (QA) with...; Region: QPRTase; cd01572
633149002658	dimerization interface [polypeptide binding]; other site
633149002659	active site
633149002660	Cell wall hydrolyses involved in spore germination [Cell envelope biogenesis, outer membrane]; Region: SleB; COG3773
633149002661	Cell Wall Hydrolase; Region: Hydrolase_2; pfam07486
633149002662	FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202
633149002663	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
633149002664	putative active site [active]
633149002665	heme pocket [chemical binding]; other site
633149002666	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
633149002667	FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202
633149002668	putative active site [active]
633149002669	heme pocket [chemical binding]; other site
633149002670	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
633149002671	putative active site [active]
633149002672	heme pocket [chemical binding]; other site
633149002673	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
633149002674	GAF domain; Region: GAF; pfam01590
633149002675	PAS domain S-box; Region: sensory_box; TIGR00229
633149002676	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
633149002677	putative active site [active]
633149002678	heme pocket [chemical binding]; other site
633149002679	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
633149002680	dimer interface [polypeptide binding]; other site
633149002681	phosphorylation site [posttranslational modification]
633149002682	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
633149002683	ATP binding site [chemical binding]; other site
633149002684	Mg2+ binding site [ion binding]; other site
633149002685	G-X-G motif; other site
633149002686	FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784
633149002687	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
633149002688	active site
633149002689	phosphorylation site [posttranslational modification]
633149002690	intermolecular recognition site; other site
633149002691	dimerization interface [polypeptide binding]; other site
633149002692	DNA-binding ferritin-like protein (oxidative damage protectant) [Inorganic ion transport and metabolism]; Region: Dps; COG0783
633149002693	DPS protein, ferritin-like diiron-binding domain; Region: DPS; cd01043
633149002694	dimerization interface [polypeptide binding]; other site
633149002695	DPS ferroxidase diiron center [ion binding]; other site
633149002696	ion pore; other site
633149002697	Cell wall hydrolyses involved in spore germination [Cell envelope biogenesis, outer membrane]; Region: SleB; COG3773
633149002698	Cell Wall Hydrolase; Region: Hydrolase_2; pfam07486
633149002699	GAF domain; Region: GAF; pfam01590
633149002700	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
633149002701	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
633149002702	PAS fold; Region: PAS_3; pfam08447
633149002703	putative active site [active]
633149002704	heme pocket [chemical binding]; other site
633149002705	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920
633149002706	HWE histidine kinase; Region: HWE_HK; smart00911
633149002707	FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784
633149002708	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
633149002709	active site
633149002710	phosphorylation site [posttranslational modification]
633149002711	intermolecular recognition site; other site
633149002712	dimerization interface [polypeptide binding]; other site
633149002713	Sensors of blue-light using FAD; Region: BLUF; pfam04940
633149002714	thioredoxin-disulfide reductase; Region: TRX_reduct; TIGR01292
633149002715	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
633149002716	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
633149002717	Predicted nucleoside-diphosphate-sugar epimerase [Cell envelope biogenesis, outer membrane]; Region: COG3660
633149002718	Mitochondrial fission ELM1; Region: Mito_fiss_Elm1; pfam06258
633149002719	transcription elongation factor GreA; Reviewed; Region: greA; PRK00226
633149002720	Transcription elongation factor, N-terminal; Region: GreA_GreB_N; pfam03449
633149002721	Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272
633149002722	Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625
633149002723	GST_N family, Saccharomyces cerevisiae GTT1-like subfamily; composed of predominantly uncharacterized proteins with similarity to the S. cerevisiae GST protein, GTT1, and the Schizosaccharomyces pombe GST-III. GSTs are cytosolic dimeric proteins involved...; Region: GST_N_GTT1_like; cd03046
633149002724	putative C-terminal domain interface [polypeptide binding]; other site
633149002725	putative GSH binding site (G-site) [chemical binding]; other site
633149002726	putative dimer interface [polypeptide binding]; other site
633149002727	C-terminal, alpha helical domain of GTT1-like Glutathione S-transferases; Region: GST_C_GTT1_like; cd03189
633149002728	putative N-terminal domain interface [polypeptide binding]; other site
633149002729	putative dimer interface [polypeptide binding]; other site
633149002730	putative substrate binding pocket (H-site) [chemical binding]; other site
633149002731	selenophosphate synthetase; Provisional; Region: PRK00943
633149002732	Selenophosphate synthetase  (SelD) catalyzes the conversion of selenium to selenophosphate which is required by a number of bacterial, archaeal and eukaryotic organisms for synthesis of Secys-tRNA, the precursor of selenocysteine in selenoenzymes. The...; Region: SelD; cd02195
633149002733	dimerization interface [polypeptide binding]; other site
633149002734	putative ATP binding site [chemical binding]; other site
633149002735	tRNA 2-selenouridine synthase; Region: tRNA_sel_U_synt; TIGR03167
633149002736	Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cl00125
633149002737	active site residue [active]
633149002738	This family includes the Gtfs, a group of homologous glycosyltransferases involved in the final stages of the biosynthesis of antibiotics vancomycin and related chloroeremomycin. Gtfs transfer sugar moieties from an activated NDP-sugar donor to the...; Region: GT1_Gtf_like; cd03784
633149002739	active site
633149002740	TDP-binding site; other site
633149002741	acceptor substrate-binding pocket; other site
633149002742	Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301
633149002743	Sodium:dicarboxylate symporter family; Region: SDF; pfam00375
633149002744	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
633149002745	PAS domain; Region: PAS_9; pfam13426
633149002746	putative active site [active]
633149002747	heme pocket [chemical binding]; other site
633149002748	hypothetical protein; Provisional; Region: PRK13559
633149002749	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
633149002750	putative active site [active]
633149002751	heme pocket [chemical binding]; other site
633149002752	HWE histidine kinase; Region: HWE_HK; smart00911
633149002753	von Willebrand factor; Region: vWF_A; pfam12450
633149002754	Uncharacterized protein containing a von Willebrand factor type A (vWA) domain [General function prediction only]; Region: COG2304
633149002755	VWA subgroup: Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b...; Region: vWA_subgroup; cd01465
633149002756	metal ion-dependent adhesion site (MIDAS); other site
633149002757	Domain of unknown function (DUF3520); Region: DUF3520; pfam12034
633149002758	Protein of unknown function (DUF1294); Region: DUF1294; pfam06961
633149002759	carbamoyl phosphate synthase large subunit; Reviewed; Region: carB; PRK05294
633149002760	Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289
633149002761	Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786
633149002762	Carbamoyl-phosphate synthetase large chain, oligomerisation domain; Region: CPSase_L_D3; pfam02787
633149002763	Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289
633149002764	ATP-grasp domain; Region: ATP-grasp_4; cl17255
633149002765	Methylglyoxal synthase-like domain from type II glutamine-dependent carbamoyl phosphate synthetase (CSP). CSP, a CarA and CarB heterodimer, catalyzes the production of carbamoyl phosphate which is subsequently employed in the metabolic pathways...; Region: MGS_CPS_II; cd01424
633149002766	IMP binding site; other site
633149002767	dimer interface [polypeptide binding]; other site
633149002768	partial ornithine binding site; other site
633149002769	Outer membrane cobalamin receptor protein [Coenzyme metabolism]; Region: BtuB; COG4206
633149002770	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244
633149002771	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244
633149002772	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244
633149002773	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244
633149002774	Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629
633149002775	Predicted hydrolase (HAD superfamily) [General function prediction only]; Region: COG1011
633149002776	REG-2-like, HAD superfamily (subfamily IA) hydrolase; Region: DREG-2; TIGR02252
633149002777	carbonyl reductase sniffer-like, classical (c) SDRs; Region: carb_red_sniffer_like_SDR_c; cd05325
633149002778	NADP binding site [chemical binding]; other site
633149002779	homodimer interface [polypeptide binding]; other site
633149002780	active site
633149002781	carbamoyl phosphate synthase small subunit; Reviewed; Region: PRK12564
633149002782	Carbamoyl-phosphate synthase small chain, CPSase domain; Region: CPSase_sm_chain; smart01097
633149002783	Small chain of the glutamine-dependent form of carbamoyl phosphate synthase, CPSase II; Region: GATase1_CPSase; cd01744
633149002784	catalytic site [active]
633149002785	subunit interface [polypeptide binding]; other site
633149002786	Patatins and Phospholipases; Region: Patatin_and_cPLA2; cl11396
633149002787	active site
633149002788	nucleophile elbow; other site
633149002789	Patatins and Phospholipases; Region: Patatin_and_cPLA2; cl11396
633149002790	nucleophile elbow; other site
633149002791	DNA primase; Validated; Region: dnaG; PRK05667
633149002792	CHC2 zinc finger; Region: zf-CHC2; cl17510
633149002793	DNA primase catalytic core, N-terminal domain; Region: Toprim_N; pfam08275
633149002794	TOPRIM_DnaG_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of proteins similar to Escherichia coli DnaG. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_DnaG_primases; cd03364
633149002795	active site
633149002796	metal binding site [ion binding]; metal-binding site
633149002797	interdomain interaction site; other site
633149002798	Sigma-70 factor, region 1.1; Region: Sigma70_r1_1; pfam03979
633149002799	Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140
633149002800	Sigma-70, non-essential region; Region: Sigma70_ner; pfam04546
633149002801	RNA polymerase sigma factor RpoD, C-terminal domain; Region: RpoD_Cterm; TIGR02393
633149002802	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
633149002803	Sigma-70 region 3; Region: Sigma70_r3; pfam04539
633149002804	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
633149002805	DNA binding residues [nucleotide binding]
633149002806	This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632
633149002807	active site
633149002808	Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659
633149002809	Sulfate transporter N-terminal domain with GLY motif; Region: Sulfate_tra_GLY; pfam13792
633149002810	Sulfate transporter family; Region: Sulfate_transp; pfam00916
633149002811	Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function; Region: STAS_SulP_like_sulfate_transporter; cd07042
633149002812	Uncharacterized iron-regulated membrane protein [Function unknown]; Region: PiuB; COG3182
633149002813	PepSY-associated TM helix; Region: PepSY_TM_1; pfam13172
633149002814	TonB-dependent siderophore receptor; Region: TonB-siderophor; TIGR01783
633149002815	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
633149002816	N-terminal plug; other site
633149002817	ligand-binding site [chemical binding]; other site
633149002818	Protein of unknown function (DUF1428); Region: DUF1428; pfam07237
633149002819	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
633149002820	This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_24; cd09012
633149002821	Predicted transcriptional regulators [Transcription]; Region: COG1733
633149002822	HxlR-like helix-turn-helix; Region: HxlR; pfam01638
633149002823	SCP-2 sterol transfer family; Region: SCP2; pfam02036
633149002824	Flagellar hook protein FlgE [Cell motility and secretion]; Region: FlgE; COG1749
633149002825	Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198
633149002826	metal ion-dependent adhesion site (MIDAS); other site
633149002827	monofunctional biosynthetic peptidoglycan transglycosylase; Provisional; Region: mtgA; PRK00056
633149002828	Transglycosylase; Region: Transgly; cl17702
633149002829	FOG: WD40 repeat [General function prediction only]; Region: COG2319
633149002830	WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cl02567
633149002831	structural tetrad; other site
633149002832	C factor cell-cell signaling protein; Provisional; Region: PRK09009
633149002833	carbonyl reductase sniffer-like, classical (c) SDRs; Region: carb_red_sniffer_like_SDR_c; cd05325
633149002834	NADP binding site [chemical binding]; other site
633149002835	homodimer interface [polypeptide binding]; other site
633149002836	active site
633149002837	Putative GTPases (G3E family) [General function prediction only]; Region: COG0523
633149002838	The function of this protein family is unkown. The amino acid sequence of YjiA protein in E. coli contains several conserved motifs that characterizes it as a P-loop GTPase. YijA gene is among the genes significantly induced in response to DNA-damage...; Region: CobW_like; cd03112
633149002839	P-loop, Walker A motif; other site
633149002840	Base recognition motif; other site
633149002841	Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; pfam07683
633149002842	Protein of unknown function (DUF1295); Region: DUF1295; cl17837
633149002843	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
633149002844	Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109
633149002845	Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625
633149002846	Glutathione S-transferase (GST) family, N-terminal domain; a large, diverse group of cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of  glutathione (GSH) with a wide range of endogenous and xenobiotic...; Region: GST_N_family; cd00570
633149002847	C-terminal domain interface [polypeptide binding]; other site
633149002848	GSH binding site (G-site) [chemical binding]; other site
633149002849	dimer interface [polypeptide binding]; other site
633149002850	C-terminal, alpha helical domain of the Glutathione S-transferase family; Region: GST_C_family; cl02776
633149002851	substrate binding pocket (H-site) [chemical binding]; other site
633149002852	N-terminal domain interface [polypeptide binding]; other site
633149002853	Glucokinase; Region: Glucokinase; pfam02685
633149002854	glucokinase, proteobacterial type; Region: glk; TIGR00749
633149002855	phosphogluconate dehydratase; Validated; Region: PRK09054
633149002856	6-phosphogluconate dehydratase; Region: edd; TIGR01196
633149002857	6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase [Carbohydrate transport and metabolism]; Region: NagB; COG0363
633149002858	6PGL: 6-Phosphogluconolactonase (6PGL) subfamily; 6PGL catalyzes the second step of the oxidative phase of the pentose phosphate pathway, the hydrolyzation of 6-phosphoglucono-1,5-lactone (delta form) to 6-phosphogluconate. 6PGL is thought to guard...; Region: 6PGL; cd01400
633149002859	putative active site [active]
633149002860	glucose-6-phosphate 1-dehydrogenase; Validated; Region: PRK05722
633149002861	Glucose-6-phosphate dehydrogenase, NAD binding domain; Region: G6PD_N; pfam00479
633149002862	Glucose-6-phosphate dehydrogenase, C-terminal domain; Region: G6PD_C; pfam02781
633149002863	bifunctional phosphoribosyl-AMP cyclohydrolase/phosphoribosyl-ATP pyrophosphatase protein; Reviewed; Region: PRK02759
633149002864	Phosphoribosyl-AMP cyclohydrolase [Amino acid transport and metabolism]; Region: HisI; COG0139
633149002865	Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in Escherichia coli phosphoribosyl-ATP pyrophosphohydrolase (HisIE or PRATP-PH) and its homologs; Region: NTP-PPase_HisIE_like; cd11534
633149002866	metal binding site [ion binding]; metal-binding site
633149002867	The cyclase subunit of imidazoleglycerol phosphate synthase (HisF). Imidazole glycerol phosphate synthase (IGPS) catalyzes the fifth step of histidine biosynthesis, the formation of the imidazole ring. IGPS converts N1-(5'-phosphoribulosyl)...; Region: HisF; cd04731
633149002868	Histidine biosynthesis protein; Region: His_biosynth; pfam00977
633149002869	substrate binding site [chemical binding]; other site
633149002870	glutamase interaction surface [polypeptide binding]; other site
633149002871	HisA.  Phosphoribosylformimino-5-aminoimidazole carboxamide ribonucleotide (ProFAR) isomerase catalyzes the fourth step in histidine biosynthesis, an isomerisation of the aminoaldose moiety of ProFAR to the aminoketose of PRFAR (N-(5'-phospho-D-1...; Region: HisA; cd04732
633149002872	phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase; Region: TIGR00007
633149002873	catalytic residues [active]
633149002874	imidazole glycerol phosphate synthase subunit HisH; Provisional; Region: hisH; PRK13141
633149002875	Type 1 glutamine amidotransferase (GATase1) domain found in imidazole glycerol phosphate synthase (IGPS); Region: GATase1_IGP_Synthase; cd01748
633149002876	putative active site [active]
633149002877	oxyanion strand; other site
633149002878	catalytic triad [active]
633149002879	histidinol-phosphate aminotransferase; Region: hisC; TIGR01141
633149002880	Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321
633149002881	Imidazoleglycerol-phosphate dehydratase; Region: IGPD; cd07914
633149002882	putative active site pocket [active]
633149002883	4-fold oligomerization interface [polypeptide binding]; other site
633149002884	metal binding residues [ion binding]; metal-binding site
633149002885	3-fold/trimer interface [polypeptide binding]; other site
633149002886	Histidinol dehydrogenase, HisD, E.C 1.1.1.23. Histidinol dehydrogenase catalyzes the last two steps in the L-histidine biosynthesis pathway, which is conserved in bacteria, archaea, fungi, and plants. These last two steps are (i) the NAD-dependent...; Region: Histidinol_dh; cd06572
633149002887	histidinol dehydrogenase; Region: hisD; TIGR00069
633149002888	NAD binding site [chemical binding]; other site
633149002889	dimerization interface [polypeptide binding]; other site
633149002890	product binding site; other site
633149002891	substrate binding site [chemical binding]; other site
633149002892	zinc binding site [ion binding]; other site
633149002893	catalytic residues [active]
633149002894	ATP phosphoribosyltransferase; Reviewed; Region: hisG; PRK00489
633149002895	ATP phosphoribosyltransferase; Region: hisG; TIGR00070
633149002896	ATP phosphoribosyltransferase, C-terminal domain; Region: HisG_C-term; TIGR03455
633149002897	Trp repressor protein; Region: Trp_repressor; cl17266
633149002898	CHASE4 domain; Region: CHASE4; cl01308
633149002899	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
633149002900	dimerization interface [polypeptide binding]; other site
633149002901	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
633149002902	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
633149002903	metal binding site [ion binding]; metal-binding site
633149002904	active site
633149002905	I-site; other site
633149002906	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
633149002907	Plastocyanin [Energy production and conversion]; Region: PetE; COG3794
633149002908	Protein of unknown function (DUF3034); Region: DUF3034; pfam11231
633149002909	superfamily containing globins and truncated hemoglobins; Region: globin_like; cl00280
633149002910	heme-binding site [chemical binding]; other site
633149002911	Domain of unknown function (DUF4117); Region: DUF4117; pfam13491
633149002912	DNA segregation ATPase FtsK/SpoIIIE and related proteins [Cell division and chromosome partitioning]; Region: FtsK; COG1674
633149002913	FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580
633149002914	Ftsk gamma domain; Region: Ftsk_gamma; pfam09397
633149002915	Outer membrane lipoprotein-sorting protein [Cell envelope biogenesis, outer membrane]; Region: LolA; COG2834
633149002916	Outer membrane lipoprotein carrier protein LolA; Region: LolA; cl17548
633149002917	Escherichia coli exonuclease III (ExoIII) and Neisseria meningitides NExo-like subfamily of the ExoIII family purinic/apyrimidinic (AP) endonucleases; Region: ExoIII-like_AP-endo; cd09086
633149002918	putative catalytic site [active]
633149002919	putative phosphate binding site [ion binding]; other site
633149002920	active site
633149002921	metal binding site A [ion binding]; metal-binding site
633149002922	DNA binding site [nucleotide binding]
633149002923	putative AP binding site [nucleotide binding]; other site
633149002924	putative metal binding site B [ion binding]; other site
633149002925	Uncharacterized conserved protein [Function unknown]; Region: COG2308
633149002926	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2307
633149002927	A predicted alpha-helical domain with a conserved ER motif; Region: Alpha-E; pfam04168
633149002928	Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305
633149002929	Bacterial transglutaminase-like N-terminal region; Region: Bact_transglu_N; pfam08379
633149002930	Transglutaminase-like superfamily; Region: Transglut_core; pfam01841
633149002931	Predicted proteasome-type protease [Posttranslational modification, protein turnover, chaperones]; Region: COG3484
633149002932	The Ntn hydrolases (N-terminal nucleophile) are a diverse superfamily of of enzymes that are activated autocatalytically via an N-terminally lcated nucleophilic amino acid.  N-terminal nucleophile (NTN-) hydrolase superfamily, which contains a...; Region: Ntn_hydrolase; cl00467
633149002933	active site
633149002934	Outer membrane receptor for monomeric catechols [Inorganic ion transport and metabolism]; Region: Fiu; COG4774
633149002935	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
633149002936	N-terminal plug; other site
633149002937	ligand-binding site [chemical binding]; other site
633149002938	Fe(II)-dependent oxygenase superfamily protein; Provisional; Region: PRK05467
633149002939	Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629
633149002940	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244
633149002941	UDP-N-acetylmuramate-alanine ligase [Cell envelope biogenesis, outer membrane]; Region: MurC; COG0773
633149002942	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
633149002943	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
633149002944	LD-Carboxypeptidase, a serine protease, includes microcin C7 self immunity protein; Region: Peptidase_S66; cd07025
633149002945	dimer interface [polypeptide binding]; other site
633149002946	catalytic triad [active]
633149002947	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
633149002948	Protein-L-isoaspartate carboxylmethyltransferase [Posttranslational modification, protein turnover, chaperones]; Region: Pcm; COG2518
633149002949	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
633149002950	S-adenosylmethionine binding site [chemical binding]; other site
633149002951	O-succinylhomoserine (thiol)-lyase; Region: O_succ_thio_ly; TIGR02080
633149002952	CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614
633149002953	homodimer interface [polypeptide binding]; other site
633149002954	substrate-cofactor binding pocket; other site
633149002955	pyridoxal 5'-phosphate binding site [chemical binding]; other site
633149002956	catalytic residue [active]
633149002957	homoserine O-acetyltransferase; Provisional; Region: PRK08775
633149002958	homoserine O-acetyltransferase; Provisional; Region: metX; cl17114
633149002959	Amino Acid Kinases (AAK) superfamily, catalytic domain; present in such enzymes like N-acetylglutamate kinase (NAGK), carbamate kinase (CK), aspartokinase (AK), glutamate-5-kinase (G5K) and UMP kinase (UMPK). The AAK superfamily includes kinases that...; Region: AAK; cl00452
633149002960	nucleotide binding site [chemical binding]; other site
633149002961	substrate binding site [chemical binding]; other site
633149002962	Homoserine dehydrogenase, NAD binding domain; Region: NAD_binding_3; pfam03447
633149002963	Homoserine dehydrogenase [Amino acid transport and metabolism]; Region: ThrA; COG0460
633149002964	Homoserine dehydrogenase; Region: Homoserine_dh; pfam00742
633149002965	Putative homoserine kinase type II (protein kinase fold) [General function prediction only]; Region: COG2334
633149002966	Homoserine Kinase, type II. Homoserine kinase is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs), RIO kinases, actin-fragmin kinase (AFK), and...; Region: HomoserineK_II; cd05153
633149002967	putative active site [active]
633149002968	putative substrate binding site [chemical binding]; other site
633149002969	ATP binding site [chemical binding]; other site
633149002970	Domain of unknown function, appears to be related to a diverse group of endonucleases; Region: Endonuclease_DUF559; cd01038
633149002971	putative active site [active]
633149002972	Threonine synthase catalyzes the final step of threonine biosynthesis. The conversion of O-phosphohomoserine into threonine and inorganic phosphate is pyridoxal 5'-phosphate dependent. The Thr-synth_1 CD includes members from higher plants; Region: Thr-synth_2; cd01560
633149002973	Threonine synthase [Amino acid transport and metabolism]; Region: ThrC; COG0498
633149002974	pyridoxal 5'-phosphate binding site [chemical binding]; other site
633149002975	catalytic residue [active]
633149002976	tRNA-dihydrouridine synthase A; Provisional; Region: PRK11815
633149002977	Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801
633149002978	FMN binding site [chemical binding]; other site
633149002979	active site
633149002980	catalytic residues [active]
633149002981	substrate binding site [chemical binding]; other site
633149002982	Bacterial aspartate proteases, retropepsin-like protease family; Region: retropepsin_like_bacteria; cd05483
633149002983	catalytic motif [active]
633149002984	Catalytic residue [active]
633149002985	Protein of unknown function (DUF1289); Region: DUF1289; pfam06945
633149002986	ABC exporter membrane fusion protein, DevB family; Region: heterocyst_DevB; TIGR02971
633149002987	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
633149002988	HlyD family secretion protein; Region: HlyD_3; pfam13437
633149002989	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
633149002990	ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255
633149002991	Walker A/P-loop; other site
633149002992	ATP binding site [chemical binding]; other site
633149002993	Q-loop/lid; other site
633149002994	ABC transporter signature motif; other site
633149002995	Walker B; other site
633149002996	D-loop; other site
633149002997	H-loop/switch region; other site
633149002998	MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
633149002999	FtsX-like permease family; Region: FtsX; pfam02687
633149003000	Peptidase S46; Region: Peptidase_S46; pfam10459
633149003001	Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365
633149003002	Peptidase S46; Region: Peptidase_S46; pfam10459
633149003003	Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365
633149003004	Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673
633149003005	Acetyltransferase (GNAT) domain; Region: Acetyltransf_7; pfam13508
633149003006	Coenzyme A binding pocket [chemical binding]; other site
633149003007	Domain of unknown function (DUF4287); Region: DUF4287; pfam14117
633149003008	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
633149003009	CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; cl00453
633149003010	Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA_cladeB; cd00884
633149003011	active site clefts [active]
633149003012	zinc binding site [ion binding]; other site
633149003013	dimer interface [polypeptide binding]; other site
633149003014	Replication protein A, class 2b aminoacyl-tRNA synthetases, and related proteins with oligonucleotide/oligosaccharide (OB) fold; Region: RPA_2b-aaRSs_OBF_like; cl09930
633149003015	generic binding surface II; other site
633149003016	generic binding surface I; other site
633149003017	Bacteriocin-protection, YdeI or OmpD-Associated; Region: OmdA; pfam13376
633149003018	excinuclease ABC subunit C; Validated; Region: uvrC; PRK00558
633149003019	Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434
633149003020	GIY-YIG motif/motif A; other site
633149003021	active site
633149003022	catalytic site [active]
633149003023	putative DNA binding site [nucleotide binding]; other site
633149003024	metal binding site [ion binding]; metal-binding site
633149003025	UvrC Helix-hairpin-helix N-terminal; Region: UvrC_HhH_N; pfam08459
633149003026	alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859
633149003027	polyphosphate kinase 2, PA0141 family; Region: PPK2_P_aer; TIGR03707
633149003028	Extensin-like protein C-terminus; Region: Extensin-like_C; pfam06904
633149003029	Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea.  CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458
633149003030	DNA-binding site [nucleotide binding]; DNA binding site
633149003031	RNA-binding motif; other site
633149003032	Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697
633149003033	EamA-like transporter family; Region: EamA; pfam00892
633149003034	Haloacid dehalogenase-like hydrolase; Region: HAD_2; pfam13419
633149003035	REG-2-like, HAD superfamily (subfamily IA) hydrolase; Region: DREG-2; TIGR02252
633149003036	glutamyl-Q tRNA(Asp) synthetase; Reviewed; Region: PRK05710
633149003037	active site
633149003038	HIGH motif; other site
633149003039	nucleotide binding site [chemical binding]; other site
633149003040	active site
633149003041	KMSKS motif; other site
633149003042	endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056
633149003043	endonuclease III; Region: ENDO3c; smart00478
633149003044	minor groove reading motif; other site
633149003045	helix-hairpin-helix signature motif; other site
633149003046	substrate binding pocket [chemical binding]; other site
633149003047	active site
633149003048	Predicted membrane protein [Function unknown]; Region: COG2860
633149003049	UPF0126 domain; Region: UPF0126; pfam03458
633149003050	UPF0126 domain; Region: UPF0126; pfam03458
633149003051	Restriction endonuclease [Defense mechanisms]; Region: McrA; COG1403
633149003052	HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085
633149003053	active site
633149003054	Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620
633149003055	putative fimbrial protein TcfA; Provisional; Region: PRK15308
633149003056	Response regulator receiver domain; Region: Response_reg; pfam00072
633149003057	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
633149003058	active site
633149003059	phosphorylation site [posttranslational modification]
633149003060	intermolecular recognition site; other site
633149003061	dimerization interface [polypeptide binding]; other site
633149003062	CheD chemotactic sensory transduction; Region: CheD; cl00810
633149003063	chemotaxis regulatory protein CheY; Provisional; Region: PRK10610
633149003064	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
633149003065	active site
633149003066	phosphorylation site [posttranslational modification]
633149003067	intermolecular recognition site; other site
633149003068	dimerization interface [polypeptide binding]; other site
633149003069	chemotaxis-specific methylesterase; Provisional; Region: PRK00742
633149003070	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
633149003071	active site
633149003072	phosphorylation site [posttranslational modification]
633149003073	intermolecular recognition site; other site
633149003074	dimerization interface [polypeptide binding]; other site
633149003075	CheB methylesterase; Region: CheB_methylest; pfam01339
633149003076	CheR methyltransferase, all-alpha domain; Region: CheR_N; pfam03705
633149003077	Methyltransferase, chemotaxis proteins; Region: MeTrc; smart00138
633149003078	CheR methyltransferase, SAM binding domain; Region: CheR; pfam01739
633149003079	CheW, a small regulator protein, unique to the chemotaxis signalling in prokaryotes and archea. CheW interacts with the histidine kinase CheA, most likely with the related regulatory domain of CheA. CheW is proposed to form signalling arrays together...; Region: CheW; cd00732
633149003080	putative CheA interaction surface; other site
633149003081	Chemotaxis protein histidine kinase and related kinases [Cell motility and secretion / Signal transduction mechanisms]; Region: CheA; COG0643
633149003082	Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088
633149003083	putative binding surface; other site
633149003084	active site
633149003085	Signal transducing histidine kinase, homodimeric domain; Region: H-kinase_dim; pfam02895
633149003086	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
633149003087	ATP binding site [chemical binding]; other site
633149003088	Mg2+ binding site [ion binding]; other site
633149003089	G-X-G motif; other site
633149003090	CheA regulatory domain; CheA is a histidine protein kinase present in bacteria and archea. Activated by the chemotaxis receptor a histidine phosphoryl group from CheA is passed directly to an aspartate in the response regulator CheY. This signalling...; Region: CheA_reg; cd00731
633149003091	Response regulator receiver domain; Region: Response_reg; pfam00072
633149003092	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
633149003093	active site
633149003094	phosphorylation site [posttranslational modification]
633149003095	intermolecular recognition site; other site
633149003096	dimerization interface [polypeptide binding]; other site
633149003097	Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043
633149003098	anti sigma factor interaction site; other site
633149003099	regulatory phosphorylation site [posttranslational modification]; other site
633149003100	CHASE3 domain; Region: CHASE3; cl05000
633149003101	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
633149003102	dimerization interface [polypeptide binding]; other site
633149003103	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
633149003104	PAS domain; Region: PAS_9; pfam13426
633149003105	putative active site [active]
633149003106	heme pocket [chemical binding]; other site
633149003107	Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283
633149003108	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
633149003109	dimer interface [polypeptide binding]; other site
633149003110	putative CheW interface [polypeptide binding]; other site
633149003111	Bacterial protein of unknown function (Gcw_chp); Region: Gcw_chp; cl09901
633149003112	response regulator FixJ; Provisional; Region: fixJ; PRK09390
633149003113	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
633149003114	active site
633149003115	phosphorylation site [posttranslational modification]
633149003116	intermolecular recognition site; other site
633149003117	dimerization interface [polypeptide binding]; other site
633149003118	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
633149003119	DNA binding residues [nucleotide binding]
633149003120	dimerization interface [polypeptide binding]; other site
633149003121	phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966
633149003122	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
633149003123	dimer interface [polypeptide binding]; other site
633149003124	phosphorylation site [posttranslational modification]
633149003125	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
633149003126	ATP binding site [chemical binding]; other site
633149003127	G-X-G motif; other site
633149003128	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
633149003129	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
633149003130	dimer interface [polypeptide binding]; other site
633149003131	phosphorylation site [posttranslational modification]
633149003132	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
633149003133	ATP binding site [chemical binding]; other site
633149003134	Mg2+ binding site [ion binding]; other site
633149003135	G-X-G motif; other site
633149003136	Response regulator receiver domain; Region: Response_reg; pfam00072
633149003137	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
633149003138	active site
633149003139	phosphorylation site [posttranslational modification]
633149003140	intermolecular recognition site; other site
633149003141	dimerization interface [polypeptide binding]; other site
633149003142	Response regulator receiver domain; Region: Response_reg; pfam00072
633149003143	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
633149003144	active site
633149003145	phosphorylation site [posttranslational modification]
633149003146	intermolecular recognition site; other site
633149003147	dimerization interface [polypeptide binding]; other site
633149003148	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3295
633149003149	PepSY-associated TM helix; Region: PepSY_TM_1; pfam13172
633149003150	Predicted periplasmic protein (DUF2271); Region: DUF2271; cl17856
633149003151	Domain of unknown function (DUF4198); Region: DUF4198; pfam10670
633149003152	Membrane-associated lipoprotein involved in thiamine biosynthesis [Coenzyme metabolism]; Region: ApbE; COG1477
633149003153	ApbE family; Region: ApbE; pfam02424
633149003154	Flavodoxin; Region: Flavodoxin_1; pfam00258
633149003155	Cytochrome p450- like alpha subunits of E. coli sulfite reductase (SiR) multimerize with beta subunits to catalyze the NADPH dependent reduction of sulfite to sulfide. Beta subunits have an Fe4S4 cluster and a siroheme, while the alpha subunits (cysJ...; Region: SiR_like1; cd06200
633149003156	FAD binding pocket [chemical binding]; other site
633149003157	FAD binding motif [chemical binding]; other site
633149003158	catalytic residues [active]
633149003159	NAD binding pocket [chemical binding]; other site
633149003160	phosphate binding motif [ion binding]; other site
633149003161	beta-alpha-beta structure motif; other site
633149003162	Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305
633149003163	Transglutaminase-like superfamily; Region: Transglut_core; pfam01841
633149003164	Peptidase M1 family Aminopeptidase N; Region: M1_APN_4; cd09603
633149003165	Zn binding site [ion binding]; other site
633149003166	50S ribosomal protein L28; Reviewed; Region: rpmB; PRK00359
633149003167	Protein of unknown function (DUF3617); Region: DUF3617; pfam12276
633149003168	DNA-binding transcriptional activator GcvA; Provisional; Region: PRK11139
633149003169	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
633149003170	The C-terminal substrate domain of LysR-type GcdR, TrPI, HvR and beta-lactamase regulators, and that of other closely related homologs; contains the type 2 periplasmic binding fold; Region: PBP2_GcdR_TrpI_HvrB_AmpR_like; cd08432
633149003171	dimerization interface [polypeptide binding]; other site
633149003172	substrate binding pocket [chemical binding]; other site
633149003173	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4805
633149003174	Predicted protease with the C-terminal PDZ domain [General function prediction only]; Region: COG3975
633149003175	M61 glycyl aminopeptidase; Region: Peptidase_M61; pfam05299
633149003176	PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987
633149003177	Thioredoxin reductase [Posttranslational modification, protein turnover, chaperones]; Region: TrxB; COG0492
633149003178	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
633149003179	Protein of unknown function (DUF1176); Region: DUF1176; pfam06674
633149003180	Protein of unknown function (DUF2945); Region: DUF2945; pfam11160
633149003181	Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451
633149003182	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
633149003183	NAD(P) binding site [chemical binding]; other site
633149003184	active site
633149003185	Predicted integral membrane protein [Function unknown]; Region: COG5652
633149003186	Polysaccharide biosynthesis/export protein; Region: Poly_export; pfam02563
633149003187	putative polysaccharide export protein, PEP-CTERM sytem-associated; Region: pepcterm_export; TIGR03027
633149003188	SLBB domain; Region: SLBB; pfam10531
633149003189	Bacterial transglutaminase-like cysteine proteinase BTLCP; Region: BTLCP; cl17596
633149003190	Bacterial transglutaminase-like cysteine proteinase BTLCP; Region: BTLCP; cl17596
633149003191	Uncharacterized protein conserved in bacteria (DUF2320); Region: DUF2320; pfam10082
633149003192	exopolysaccharide transport protein family; Region: eps_transp_fam; TIGR01005
633149003193	Chain length determinant protein; Region: Wzz; cl15801
633149003194	Chain length determinant protein; Region: Wzz; cl15801
633149003195	ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042
633149003196	Magnesium ion binding site [ion binding]; other site
633149003197	O-Antigen ligase; Region: Wzy_C; pfam04932
633149003198	Cell Wall Hydrolase; Region: Hydrolase_2; pfam07486
633149003199	Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149
633149003200	phosphoprotein phosphatases of the metallophosphatase superfamily, metallophosphatase domain; Region: MPP_PPP_family; cd00144
633149003201	active site
633149003202	metal binding site [ion binding]; metal-binding site
633149003203	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
633149003204	NAD(P) binding site [chemical binding]; other site
633149003205	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
633149003206	RmlD substrate binding domain; Region: RmlD_sub_bind; pfam04321
633149003207	dTDP-6-deoxy-L-lyxo-4-hexulose reductase and related proteins, extended (e) SDRs; Region: dTDP_HR_like_SDR_e; cd05254
633149003208	NADP binding site [chemical binding]; other site
633149003209	active site
633149003210	putative substrate binding site [chemical binding]; other site
633149003211	G1P_TT_short is the short form of glucose-1-phosphate thymidylyltransferase; Region: G1P_TT_short; cd02538
633149003212	glucose-1-phosphate thymidylyltransferase, short form; Region: rmlA; TIGR01207
633149003213	substrate binding site; other site
633149003214	tetramer interface; other site
633149003215	This family is most closely related to the GT1 family of glycosyltransferases. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can...; Region: GT1_like_6; cd04955
633149003216	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
633149003217	Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641
633149003218	Subfamily of Glycosyltransferase Family GT2 of unknown function; Region: GT_2_like_c; cd04186
633149003219	Probable Catalytic site; other site
633149003220	metal-binding site
633149003221	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
633149003222	This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801
633149003223	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013
633149003224	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
633149003225	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
633149003226	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013
633149003227	dTDP-D-glucose 4,6-dehydratase [Cell envelope biogenesis, outer membrane]; Region: RfbB; COG1088
633149003228	dTDP-D-glucose 4,6-dehydratase, extended (e) SDRs; Region: dTDP_GD_SDR_e; cd05246
633149003229	NAD binding site [chemical binding]; other site
633149003230	substrate binding site [chemical binding]; other site
633149003231	homodimer interface [polypeptide binding]; other site
633149003232	active site
633149003233	dTDP-4-dehydrorhamnose 3,5-epimerase; Region: dTDP_sugar_isom; pfam00908
633149003234	exopolysaccharide biosynthesis polyprenyl glycosylphosphotransferase; Region: EPS_sugtrans; TIGR03025
633149003235	Bacterial sugar transferase; Region: Bac_transf; pfam02397
633149003236	Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301
633149003237	Sodium:dicarboxylate symporter family; Region: SDF; cl00573
633149003238	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
633149003239	putative substrate translocation pore; other site
633149003240	Methyltransferase domain; Region: Methyltransf_23; pfam13489
633149003241	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
633149003242	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013
633149003243	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
633149003244	DNA-directed RNA polymerase specialized sigma subunit, sigma24 homolog [Transcription]; Region: RpoE; COG1595
633149003245	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
633149003246	DNA binding residues [nucleotide binding]
633149003247	Fe2+-dicitrate sensor, membrane component [Inorganic ion transport and metabolism / Signal transduction mechanisms]; Region: FecR; COG3712
633149003248	FecR protein; Region: FecR; pfam04773
633149003249	Secretin and TonB N terminus short domain; Region: STN; smart00965
633149003250	Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629
633149003251	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244
633149003252	isocitrate dehydrogenase; Validated; Region: PRK08299
633149003253	Protein of unknown function (DUF2939); Region: DUF2939; pfam11159
633149003254	Protein of unknown function (DUF2939); Region: DUF2939; pfam11159
633149003255	Bacterial protein of unknown function (DUF885); Region: DUF885; pfam05960
633149003256	alanyl-tRNA synthetase; Reviewed; Region: alaS; PRK00252
633149003257	Alanyl-tRNA synthetase (AlaRS) class II core catalytic domain. AlaRS is a homodimer. It is responsible for the attachment of alanine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: AlaRS_core; cd00673
633149003258	motif 1; other site
633149003259	active site
633149003260	motif 2; other site
633149003261	motif 3; other site
633149003262	Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863
633149003263	Protein of unknown function, DUF393; Region: DUF393; pfam04134
633149003264	recombinase A; Provisional; Region: recA; PRK09354
633149003265	RecA is a  bacterial enzyme which has roles in homologous recombination, DNA repair, and the induction of the SOS response.  RecA couples ATP hydrolysis to DNA strand exchange; Region: recA; cd00983
633149003266	hexamer interface [polypeptide binding]; other site
633149003267	Walker A motif; other site
633149003268	ATP binding site [chemical binding]; other site
633149003269	Walker B motif; other site
633149003270	Domain of unknown function (DUF4344); Region: DUF4344; pfam14247
633149003271	Protein of unknown function (DUF1223); Region: DUF1223; pfam06764
633149003272	Methyltransferase domain; Region: Methyltransf_11; pfam08241
633149003273	Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876
633149003274	Peptidase family M28; Region: Peptidase_M28; pfam04389
633149003275	metal binding site [ion binding]; metal-binding site
633149003276	CheR methyltransferase, all-alpha domain; Region: CheR_N; pfam03705
633149003277	Methylase of chemotaxis methyl-accepting proteins [Cell motility and secretion / Signal transduction mechanisms]; Region: CheR; COG1352
633149003278	CheR methyltransferase, SAM binding domain; Region: CheR; pfam01739
633149003279	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
633149003280	Response regulator receiver domain; Region: Response_reg; pfam00072
633149003281	active site
633149003282	phosphorylation site [posttranslational modification]
633149003283	intermolecular recognition site; other site
633149003284	dimerization interface [polypeptide binding]; other site
633149003285	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5385
633149003286	CysQ, a 3'-Phosphoadenosine-5'-phosphosulfate (PAPS) 3'-phosphatase, is a bacterial member of the inositol monophosphatase family. It has been proposed that CysQ helps control intracellular levels of PAPS, which is an intermediate in...; Region: CysQ; cd01638
633149003287	active site
633149003288	PAS fold; Region: PAS_4; pfam08448
633149003289	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
633149003290	putative active site [active]
633149003291	heme pocket [chemical binding]; other site
633149003292	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
633149003293	dimer interface [polypeptide binding]; other site
633149003294	phosphorylation site [posttranslational modification]
633149003295	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
633149003296	ATP binding site [chemical binding]; other site
633149003297	Mg2+ binding site [ion binding]; other site
633149003298	G-X-G motif; other site
633149003299	Response regulator receiver domain; Region: Response_reg; pfam00072
633149003300	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
633149003301	active site
633149003302	phosphorylation site [posttranslational modification]
633149003303	intermolecular recognition site; other site
633149003304	dimerization interface [polypeptide binding]; other site
633149003305	NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902
633149003306	Old yellow enzyme (OYE)-like FMN binding domain. OYE was the first flavin-dependent enzyme identified, however its true physiological role remains elusive to this day. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a...; Region: OYE_like_FMN; cd02933
633149003307	FMN binding site [chemical binding]; other site
633149003308	active site
633149003309	substrate binding site [chemical binding]; other site
633149003310	catalytic residue [active]
633149003311	CHASE4 domain; Region: CHASE4; cl01308
633149003312	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
633149003313	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
633149003314	metal binding site [ion binding]; metal-binding site
633149003315	active site
633149003316	I-site; other site
633149003317	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
633149003318	Peptide chain release factor RF-3 [Translation, ribosomal structure and biogenesis]; Region: PrfC; COG4108
633149003319	Release Factor 3 (RF3) protein involved in the terminal step of translocation in bacteria; Region: RF3; cd04169
633149003320	G1 box; other site
633149003321	putative GEF interaction site [polypeptide binding]; other site
633149003322	GTP/Mg2+ binding site [chemical binding]; other site
633149003323	Switch I region; other site
633149003324	G2 box; other site
633149003325	G3 box; other site
633149003326	Switch II region; other site
633149003327	G4 box; other site
633149003328	G5 box; other site
633149003329	Translation_Factor_II_like: Elongation factor Tu (EF-Tu) domain II-like proteins. Elongation factor Tu consists of three structural domains, this family represents the second domain. Domain II adopts a beta barrel structure and is involved in binding to...; Region: Translation_Factor_II_like; cl02787
633149003330	Protein of unknown function (DUF1491); Region: DUF1491; pfam07372
633149003331	Lipase.  Lipases are esterases that can hydrolyze long-chain acyl-triglycerides into di- and monoglycerides, glycerol, and free fatty acids at a water/lipid interface. A typical feature of lipases is "interfacial activation", the process of...; Region: Lipase; cl14883
633149003332	Sensors of blue-light using FAD; Region: BLUF; pfam04940
633149003333	phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966
633149003334	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
633149003335	dimer interface [polypeptide binding]; other site
633149003336	phosphorylation site [posttranslational modification]
633149003337	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
633149003338	ATP binding site [chemical binding]; other site
633149003339	Mg2+ binding site [ion binding]; other site
633149003340	G-X-G motif; other site
633149003341	Cysteine desulfurase SufE subunit [Posttranslational modification, protein turnover, chaperones]; Region: sufE; COG2166
633149003342	ROS/MUCR transcriptional regulator protein; Region: ROS_MUCR; pfam05443
633149003343	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5330
633149003344	Uncharacterized protein conserved in bacteria (DUF2336); Region: DUF2336; pfam10098
633149003345	Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031
633149003346	CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561
633149003347	dimer interface [polypeptide binding]; other site
633149003348	pyridoxal 5'-phosphate binding site [chemical binding]; other site
633149003349	catalytic residue [active]
633149003350	PAS fold; Region: PAS_4; pfam08448
633149003351	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
633149003352	GAF domain; Region: GAF; pfam01590
633149003353	PAS domain S-box; Region: sensory_box; TIGR00229
633149003354	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
633149003355	PAS fold; Region: PAS_3; pfam08447
633149003356	putative active site [active]
633149003357	heme pocket [chemical binding]; other site
633149003358	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
633149003359	Signal transduction histidine kinase, nitrogen specific [Signal transduction mechanisms]; Region: NtrB; COG3852
633149003360	putative active site [active]
633149003361	heme pocket [chemical binding]; other site
633149003362	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
633149003363	dimer interface [polypeptide binding]; other site
633149003364	phosphorylation site [posttranslational modification]
633149003365	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
633149003366	ATP binding site [chemical binding]; other site
633149003367	Mg2+ binding site [ion binding]; other site
633149003368	G-X-G motif; other site
633149003369	FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784
633149003370	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
633149003371	active site
633149003372	phosphorylation site [posttranslational modification]
633149003373	intermolecular recognition site; other site
633149003374	dimerization interface [polypeptide binding]; other site
633149003375	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920
633149003376	Histidine kinase; Region: HisKA_2; pfam07568
633149003377	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
633149003378	ATP binding site [chemical binding]; other site
633149003379	Mg2+ binding site [ion binding]; other site
633149003380	G-X-G motif; other site
633149003381	flagellum-specific ATP synthase; Validated; Region: fliI; PRK08927
633149003382	Flagellum-specific ATPase/type III secretory pathway virulence-related protein. This group of ATPases are responsible for the export of flagellum and virulence-related proteins. The bacterial flagellar motor is similar to the F0F1-ATPase, in that they...; Region: ATPase_flagellum-secretory_path_III; cd01136
633149003383	Walker A motif/ATP binding site; other site
633149003384	Walker B motif; other site
633149003385	flagellar export protein FliJ; Region: flagell_FliJ; TIGR02473
633149003386	Glycosyl hydrolase family 10; Region: Glyco_hydro_10; cl01495
633149003387	Caseinolytic protease (ClpP) is an ATP-dependent protease; Region: Clp_protease_like; cl15763
633149003388	active site
633149003389	SOUL heme-binding protein; Region: SOUL; pfam04832
633149003390	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
633149003391	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
633149003392	active site
633149003393	phosphorylation site [posttranslational modification]
633149003394	intermolecular recognition site; other site
633149003395	dimerization interface [polypeptide binding]; other site
633149003396	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
633149003397	DNA binding site [nucleotide binding]
633149003398	C-terminal domain of bacterial DnaA proteins. The DNA-binding C-terminal domain of DnaA contains a helix-turn-helix motif that specifically interacts with the DnaA box, a 9-mer motif that occurs repetitively in the replication origin oriC. Multiple...; Region: Bac_DnaA_C; cd06571
633149003399	DnaA box-binding interface [nucleotide binding]; other site
633149003400	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5330
633149003401	Uncharacterized protein conserved in bacteria (DUF2336); Region: DUF2336; pfam10098
633149003402	ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600
633149003403	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
633149003404	ABC-ATPase subunit interface; other site
633149003405	putative PBP binding loops; other site
633149003406	ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116
633149003407	ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293
633149003408	Walker A/P-loop; other site
633149003409	ATP binding site [chemical binding]; other site
633149003410	Q-loop/lid; other site
633149003411	ABC transporter signature motif; other site
633149003412	Walker B; other site
633149003413	D-loop; other site
633149003414	H-loop/switch region; other site
633149003415	NMT1/THI5 like; Region: NMT1; pfam09084
633149003416	ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488
633149003417	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
633149003418	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
633149003419	Superfamily of nucleases including Short Patch Repair (Vsr) Endonucleases, archaeal Holliday junction resolvases, MutH methy-directed DNA mismatch-repair endonucleases, and catalytic domains of many restriction endonucleases, such as EcoRI, BamHI, and...; Region: Restriction_endonuclease_like; cl00277
633149003420	putative active site [active]
633149003421	hypothetical protein; Provisional; Region: PRK05170
633149003422	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
633149003423	PAS fold; Region: PAS_3; pfam08447
633149003424	PAS domain; Region: PAS_9; pfam13426
633149003425	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
633149003426	heme pocket [chemical binding]; other site
633149003427	putative active site [active]
633149003428	phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966
633149003429	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
633149003430	putative active site [active]
633149003431	heme pocket [chemical binding]; other site
633149003432	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
633149003433	dimer interface [polypeptide binding]; other site
633149003434	phosphorylation site [posttranslational modification]
633149003435	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
633149003436	ATP binding site [chemical binding]; other site
633149003437	Mg2+ binding site [ion binding]; other site
633149003438	G-X-G motif; other site
633149003439	Response regulator receiver domain; Region: Response_reg; pfam00072
633149003440	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
633149003441	active site
633149003442	phosphorylation site [posttranslational modification]
633149003443	intermolecular recognition site; other site
633149003444	dimerization interface [polypeptide binding]; other site
633149003445	Response regulator receiver domain; Region: Response_reg; pfam00072
633149003446	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
633149003447	active site
633149003448	phosphorylation site [posttranslational modification]
633149003449	intermolecular recognition site; other site
633149003450	dimerization interface [polypeptide binding]; other site
633149003451	Uncharacterized conserved protein [Function unknown]; Region: COG5323
633149003452	Terminase-like family; Region: Terminase_6; pfam03237
633149003453	Phage-related protein [Function unknown]; Region: COG4695
633149003454	Phage portal protein; Region: Phage_portal; pfam04860
633149003455	Caudovirus prohead protease; Region: Peptidase_U35; pfam04586
633149003456	Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cd00338
633149003457	catalytic residues [active]
633149003458	catalytic nucleophile [active]
633149003459	Recombinase; Region: Recombinase; pfam07508
633149003460	Virulence-associated protein E; Region: VirE; pfam05272
633149003461	Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961
633149003462	Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and...; Region: SR_ResInv; cd03768
633149003463	catalytic residues [active]
633149003464	catalytic nucleophile [active]
633149003465	Presynaptic Site I dimer interface [polypeptide binding]; other site
633149003466	Synaptic Antiparallel dimer interface [polypeptide binding]; other site
633149003467	Synaptic Flat tetramer interface [polypeptide binding]; other site
633149003468	Synaptic Site I dimer interface [polypeptide binding]; other site
633149003469	DNA binding site [nucleotide binding]
633149003470	Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cd00569
633149003471	DNA-binding interface [nucleotide binding]; DNA binding site
633149003472	Protein of unknown function DUF262; Region: DUF262; pfam03235
633149003473	Uncharacterized conserved protein [Function unknown]; Region: COG1479
633149003474	Tellurite-resistance/Dicarboxylate Transporter (TDT) family includes sulfite sensitivity protein (sulfite efflux pump; SSU1); Region: TDT_SSU1; cd09318
633149003475	gating phenylalanine in ion channel; other site
633149003476	putative DNA-binding transcriptional regulator; Provisional; Region: PRK10837
633149003477	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
633149003478	C-terminal substrate binding domain of LysR-type transcriptional regulator CysL, which activates the transcription of the cysJI operon encoding sulfite reductase, contains the type 2 periplasmic binding fold; Region: PBP2_CysL_like; cd08420
633149003479	putative dimerization interface [polypeptide binding]; other site
633149003480	Domain of unknown function (DUF305); Region: DUF305; cl17794
633149003481	PQQ-dependent catabolism-associated beta-propeller protein; Region: PQQ_ABC_repeats; TIGR03866
633149003482	40-residue YVTN family beta-propeller repeat; Region: beta_rpt_yvtn; TIGR02276
633149003483	40-residue YVTN family beta-propeller repeat; Region: beta_rpt_yvtn; TIGR02276
633149003484	Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220
633149003485	Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446
633149003486	Phosphoprotein; Region: PP_M1; pfam03012
633149003487	Domain of unknown function (DUF4325); Region: DUF4325; pfam14213
633149003488	phage major capsid protein, HK97 family; Region: major_cap_HK97; TIGR01554
633149003489	Phage capsid family; Region: Phage_capsid; pfam05065
633149003490	Head-Tail Connector Protein gp6 of Bacteriophage HK97 and similar proteins; Region: gp6; cd08054
633149003491	Protein of unknown function (DUF3168); Region: DUF3168; pfam11367
633149003492	Phage major tail protein 2; Region: Phage_tail_2; cl11463
633149003493	Conserved hypothetical phage protein (DUF2376); Region: DUF2376; pfam09550
633149003494	S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927
633149003495	Predicted membrane protein [Function unknown]; Region: COG3152
633149003496	Conserved hypothetical protein 2217 (DUF2460); Region: DUF2460; pfam09343
633149003497	Uncharacterized conserved protein [Function unknown]; Region: COG5449
633149003498	Uncharacterized conserved protein (DUF2163); Region: DUF2163; pfam09931
633149003499	Phage conserved hypothetical protein BR0599; Region: Phage_BR0599; pfam09356
633149003500	Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791
633149003501	NlpC/P60 family; Region: NLPC_P60; cl17555
633149003502	GTA TIM-barrel-like domain; Region: GTA_TIM; pfam13547
633149003503	Putative phage tail protein; Region: Phage-tail_3; pfam13550
633149003504	curved DNA-binding protein CbpA; Provisional; Region: PRK10266
633149003505	DnaJ domain or J-domain.  DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257
633149003506	HSP70 interaction site [polypeptide binding]; other site
633149003507	C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747
633149003508	substrate binding site [polypeptide binding]; other site
633149003509	dimer interface [polypeptide binding]; other site
633149003510	phosphoserine aminotransferase; Provisional; Region: PRK03080
633149003511	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
633149003512	catalytic residue [active]
633149003513	Adenylosuccinate synthetase; Region: Adenylsucc_synt; smart00788
633149003514	Adenylosuccinate synthetase (AdSS) catalyzes the first step in the de novo biosynthesis of AMP. IMP and L-aspartate are conjugated in a two-step reaction accompanied by the hydrolysis of GTP to GDP in the presence of Mg2+. In the first step, the...; Region: AdSS; cd03108
633149003515	GDP-binding site [chemical binding]; other site
633149003516	ACT binding site; other site
633149003517	IMP binding site; other site
633149003518	Response regulator receiver domain; Region: Response_reg; pfam00072
633149003519	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
633149003520	active site
633149003521	phosphorylation site [posttranslational modification]
633149003522	intermolecular recognition site; other site
633149003523	dimerization interface [polypeptide binding]; other site
633149003524	RNA polymerase factor sigma-32; Reviewed; Region: PRK06596
633149003525	Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140
633149003526	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
633149003527	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
633149003528	DNA binding residues [nucleotide binding]
633149003529	Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564
633149003530	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
633149003531	RNA binding surface [nucleotide binding]; other site
633149003532	Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869
633149003533	active site
633149003534	Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629
633149003535	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
633149003536	N-terminal plug; other site
633149003537	ligand-binding site [chemical binding]; other site
633149003538	PhoD-like phosphatase; Region: PhoD; pfam09423
633149003539	Bacillus subtilis PhoD and related proteins, metallophosphatase domain; Region: MPP_PhoD; cd07389
633149003540	putative active site [active]
633149003541	Bacillus subtilis PhoD and related proteins, metallophosphatase domain; Region: MPP_PhoD; cd07389
633149003542	fructose-bisphosphate aldolase; Provisional; Region: PRK09197
633149003543	Tagatose-1,6-bisphosphate (TBP) aldolase and related Type B Class II aldolases. TBP aldolase is a tetrameric class II aldolase that catalyzes the reversible condensation of dihydroxyacetone phosphate with glyceraldehyde 3-phsophate to produce tagatose 1; Region: TBP_aldolase_IIB; cd00947
633149003544	intersubunit interface [polypeptide binding]; other site
633149003545	active site
633149003546	zinc binding site [ion binding]; other site
633149003547	Na+ binding site [ion binding]; other site
633149003548	phosphoglycerate kinase; Provisional; Region: pgk; PRK00073
633149003549	Phosphoglycerate kinase; Region: PGK; pfam00162
633149003550	substrate binding site [chemical binding]; other site
633149003551	hinge regions; other site
633149003552	ADP binding site [chemical binding]; other site
633149003553	catalytic site [active]
633149003554	Glyceraldehyde-3-phosphate dehydrogenase/erythrose-4-phosphate dehydrogenase [Carbohydrate transport and metabolism]; Region: GapA; COG0057
633149003555	Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; smart00846
633149003556	Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800
633149003557	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
633149003558	dimerization interface [polypeptide binding]; other site
633149003559	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
633149003560	dimer interface [polypeptide binding]; other site
633149003561	phosphorylation site [posttranslational modification]
633149003562	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
633149003563	ATP binding site [chemical binding]; other site
633149003564	Mg2+ binding site [ion binding]; other site
633149003565	G-X-G motif; other site
633149003566	osmolarity response regulator; Provisional; Region: ompR; PRK09468
633149003567	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
633149003568	active site
633149003569	phosphorylation site [posttranslational modification]
633149003570	intermolecular recognition site; other site
633149003571	dimerization interface [polypeptide binding]; other site
633149003572	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
633149003573	DNA binding site [nucleotide binding]
633149003574	transaldolase/EF-hand domain-containing protein; Provisional; Region: PRK12309
633149003575	C-terminal processing peptidase family S41; Region: Peptidase_S41; cl02526
633149003576	C-terminal peptidase (prc); Region: prc; TIGR00225
633149003577	PDZ domain, also called DHR (Dlg homologous region) or GLGF (after a conserved sequence motif). Many PDZ domains bind C-terminal polypeptides, though binding to internal (non-C-terminal) polypeptides and even to lipids has been demonstrated; Region: PDZ; cl00117
633149003578	Tricorn protease; serine protease family S41; Region: Peptidase_S41_TRI; cd07562
633149003579	Domain interface; other site
633149003580	Peptide binding site; other site
633149003581	Active site tetrad [active]
633149003582	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
633149003583	This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_16; cd07263
633149003584	Truncated hemoglobins (trHbs) are a family of oxygen-binding heme proteins found in cyanobacteria, eubacteria, unicellular eukaryotes, and plants. The truncated hemoglobins have a characteristic two-over-two alpha helical folding pattern that is distinct...; Region: Trunc_globin; cd00454
633149003585	apolar tunnel; other site
633149003586	heme binding site [chemical binding]; other site
633149003587	dimerization interface [polypeptide binding]; other site
633149003588	Transketolase [Carbohydrate transport and metabolism]; Region: TktA; COG0021
633149003589	Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012
633149003590	TPP-binding site [chemical binding]; other site
633149003591	dimer interface [polypeptide binding]; other site
633149003592	Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033
633149003593	PYR/PP interface [polypeptide binding]; other site
633149003594	dimer interface [polypeptide binding]; other site
633149003595	TPP binding site [chemical binding]; other site
633149003596	Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780
633149003597	Cell division protein ZapA; Region: ZapA; pfam05164
633149003598	5,10-methenyltetrahydrofolate synthetase; Region: MTHFS_bact; TIGR02727
633149003599	Deinococcus radiodurans DR1281 and related proteins, metallophosphatase domain; Region: MPP_DR1281; cd07382
633149003600	Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149
633149003601	putative active site [active]
633149003602	metal binding site [ion binding]; metal-binding site
633149003603	homodimer binding site [polypeptide binding]; other site
633149003604	Domain of unknown function (DUF305); Region: DUF305; pfam03713
633149003605	Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849
633149003606	Protein of unknown function (DUF2975); Region: DUF2975; pfam11188
633149003607	Predicted transcriptional regulator [Transcription]; Region: COG3655
633149003608	sequence-specific DNA binding site [nucleotide binding]; other site
633149003609	salt bridge; other site
633149003610	PhoD-like phosphatase; Region: PhoD; pfam09423
633149003611	Bacillus subtilis PhoD and related proteins, metallophosphatase domain; Region: MPP_PhoD; cd07389
633149003612	putative active site [active]
633149003613	putative metal binding site [ion binding]; other site
633149003614	Bacillus subtilis PhoD and related proteins, metallophosphatase domain; Region: MPP_PhoD; cd07389
633149003615	potential frameshift: common BLAST hit: gi|114568832|ref|YP_755512.1| peptidase domain-containing protein
633149003616	phosphoribosylformylglycinamidine synthase II; Provisional; Region: PRK01213
633149003617	PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), first repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat1; cd02203
633149003618	dimerization interface [polypeptide binding]; other site
633149003619	ATP binding site [chemical binding]; other site
633149003620	PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), second repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat2; cd02204
633149003621	dimerization interface [polypeptide binding]; other site
633149003622	ATP binding site [chemical binding]; other site
633149003623	phosphoribosylformylglycinamidine synthase I; Provisional; Region: PRK03619
633149003624	Type 1 glutamine amidotransferase (GATase1)-like domain found in Formylglycinamide ribonucleotide amidotransferase; Region: GATase1_FGAR_AT; cd01740
633149003625	putative active site [active]
633149003626	catalytic triad [active]
633149003627	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
633149003628	Major Facilitator Superfamily; Region: MFS_1; pfam07690
633149003629	putative substrate translocation pore; other site
633149003630	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
633149003631	Methyl-accepting chemotaxis protein (MCP) signalling domain; Region: MCPsignal; pfam00015
633149003632	dimer interface [polypeptide binding]; other site
633149003633	putative CheW interface [polypeptide binding]; other site
633149003634	Carbohydrate-selective porin, OprB family; Region: OprB; cl17816
633149003635	PhosphatidylEthanolamine-Binding Protein (PEBP) domain present in bacteria and archaea; Region: PEBP_bact_arch; cd00865
633149003636	substrate binding site [chemical binding]; other site
633149003637	phosphoribosylformylglycinamidine synthase subunit PurS; Reviewed; Region: PRK05974
633149003638	phosphoribosylaminoimidazole-succinocarboxamide synthase; Reviewed; Region: PRK09362
633149003639	bacterial and archaeal 5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide (SAICAR) synthase; Region: SAICAR_synt_PurC; cd01415
633149003640	ATP binding site [chemical binding]; other site
633149003641	active site
633149003642	substrate binding site [chemical binding]; other site
633149003643	Domain of unknown function (DUF1476); Region: DUF1476; pfam07345
633149003644	Secreted and surface protein containing fasciclin-like repeats [Cell envelope biogenesis, outer membrane]; Region: COG2335
633149003645	Fasciclin domain; Region: Fasciclin; pfam02469
633149003646	MUG-like Uracil-DNA glycosylase enzyme family; Region: UDG_MUG_like; cd10032
633149003647	putative active site [active]
633149003648	adenylosuccinate lyase; Provisional; Region: PRK07492
633149003649	Adenylsuccinate lyase (ASL)_subgroup 1; Region: Adenylsuccinate_lyase_1; cd01360
633149003650	tetramer interface [polypeptide binding]; other site
633149003651	active site
633149003652	GST_N family, unknown subfamily 1; composed of uncharacterized proteins, predominantly from bacteria, with similarity to GSTs. GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with...; Region: GST_N_1; cd03043
633149003653	Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625
633149003654	putative C-terminal domain interface [polypeptide binding]; other site
633149003655	putative GSH binding site (G-site) [chemical binding]; other site
633149003656	putative dimer interface [polypeptide binding]; other site
633149003657	C-terminal, alpha helical domain of an unknown subfamily 3 of Glutathione S-transferases; Region: GST_C_3; cd03194
633149003658	putative N-terminal domain interface [polypeptide binding]; other site
633149003659	putative dimer interface [polypeptide binding]; other site
633149003660	putative substrate binding pocket (H-site) [chemical binding]; other site
633149003661	Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741
633149003662	Lytic Transglycosylase (LT)  and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL).  LTs...; Region: LT_GEWL; cd00254
633149003663	N-acetyl-D-glucosamine binding site [chemical binding]; other site
633149003664	catalytic residue [active]
633149003665	Family 4 Uracil-DNA glycosylase (UDG), found exclusively in thermophilic organisms; Region: UDG_F4_TTUDGA_like; cd10030
633149003666	Fe-S cluster binding site [ion binding]; other site
633149003667	active site
633149003668	Dehydrogenases (flavoproteins) [Energy production and conversion]; Region: FixC; COG0644
633149003669	hydroxyglutarate oxidase; Provisional; Region: PRK11728
633149003670	Electron transfer flavoprotein-ubiquinone oxidoreductase; Region: ETF_QO; pfam05187
633149003671	Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668
633149003672	Mechanosensitive ion channel; Region: MS_channel; pfam00924
633149003673	Protein of unknown function (DUF465); Region: DUF465; cl01070
633149003674	3-polyprenyl-4-hydroxybenzoate decarboxylase [Coenzyme metabolism]; Region: UbiX; COG0163
633149003675	Flavoprotein; Region: Flavoprotein; pfam02441
633149003676	Protein of unknown function (DUF2390); Region: DUF2390; pfam09523
633149003677	Uncharacterized conserved small protein containing a coiled-coil domain [Function unknown]; Region: COG5481
633149003678	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
633149003679	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
633149003680	metal binding site [ion binding]; metal-binding site
633149003681	active site
633149003682	I-site; other site
633149003683	Phosphoribosylcarboxyaminoimidazole (NCAIR) mutase [Nucleotide transport and metabolism]; Region: PurE; COG0041
633149003684	phosphoribosylaminoimidazole carboxylase ATPase subunit; Reviewed; Region: PRK06019
633149003685	ATP-grasp domain; Region: ATP-grasp; pfam02222
633149003686	phosphopantetheine adenylyltransferase; Provisional; Region: coaD; PRK00168
633149003687	Phosphopantetheine adenylyltransferase; Region: PPAT; cd02163
633149003688	active site
633149003689	(T/H)XGH motif; other site
633149003690	cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the...; Region: cyclophilin; cd00317
633149003691	active site
633149003692	cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the...; Region: cyclophilin; cd00317
633149003693	active site
633149003694	exopolyphosphatase; Region: exo_poly_only; TIGR03706
633149003695	Ppx/GppA phosphatase family; Region: Ppx-GppA; pfam02541
633149003696	Hemimethylated DNA-binding protein YccV like; Region: YccV-like; cl01548
633149003697	Prokaryotic phenylalanine-4-hydroxylase (pro_PheOH); a member of the biopterin-dependent aromatic amino acid hydroxylase family of non-heme, iron(II)-dependent enzymes that also includes the eukaryotic proteins, phenylalanine-4-hydroxylase (eu_PheOH); Region: pro_PheOH; cd03348
633149003698	cofactor binding site; other site
633149003699	metal binding site [ion binding]; metal-binding site
633149003700	alpha-ketoglutarate transporter; Provisional; Region: PRK10406
633149003701	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
633149003702	putative substrate translocation pore; other site
633149003703	Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673
633149003704	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
633149003705	Coenzyme A binding pocket [chemical binding]; other site
633149003706	succinylarginine dihydrolase; Provisional; Region: PRK13281
633149003707	succinylglutamic semialdehyde dehydrogenase; Reviewed; Region: astD; PRK09457
633149003708	N-succinylglutamate 5-semialdehyde dehydrogenase, AstD-like; Region: ALDH_SGSD_AstD; cd07095
633149003709	NAD(P) binding site [chemical binding]; other site
633149003710	catalytic residues [active]
633149003711	Arginine/ornithine N-succinyltransferase beta subunit [Amino acid transport and metabolism]; Region: AstA; COG3138
633149003712	Arginine N-succinyltransferase beta subunit; Region: AstA; pfam04958
633149003713	hypothetical protein; Provisional; Region: PRK07338
633149003714	M20 Peptidase Glutamate carboxypeptidase, a periplasmic enzyme; Region: M20_CPDG2; cd03885
633149003715	metal binding site [ion binding]; metal-binding site
633149003716	dimer interface [polypeptide binding]; other site
633149003717	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2911
633149003718	AsmA-like C-terminal region; Region: AsmA_2; pfam13502
633149003719	Family of unknown function (DUF490); Region: DUF490; pfam04357
633149003720	Outer membrane protein [Cell envelope biogenesis, outer membrane]; Region: COG0729
633149003721	Surface antigen; Region: Bac_surface_Ag; pfam01103
633149003722	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
633149003723	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
633149003724	dimer interface [polypeptide binding]; other site
633149003725	phosphorylation site [posttranslational modification]
633149003726	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
633149003727	ATP binding site [chemical binding]; other site
633149003728	Mg2+ binding site [ion binding]; other site
633149003729	G-X-G motif; other site
633149003730	Response regulator receiver domain; Region: Response_reg; pfam00072
633149003731	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
633149003732	active site
633149003733	phosphorylation site [posttranslational modification]
633149003734	intermolecular recognition site; other site
633149003735	dimerization interface [polypeptide binding]; other site
633149003736	DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182
633149003737	DNA binding site [nucleotide binding]
633149003738	active site
633149003739	Int/Topo IB signature motif; other site
633149003740	catalytic residues [active]
633149003741	Phage protein Gp37/Gp68; Region: Gp37_Gp68; cl15384
633149003742	Phage protein Gp37/Gp68; Region: Gp37_Gp68; cl15384
633149003743	ParB-like nuclease domain; Region: ParBc; pfam02195
633149003744	Uncharacterized conserved protein [Function unknown]; Region: COG4748
633149003745	Type I restriction enzyme R protein N terminus (HSDR_N); Region: HSDR_N; cl14958
633149003746	The S24, S26 LexA/signal peptidase superfamily contains LexA-related and type I signal peptidase families. The S24 LexA protein domains include: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC 3.4.21.88), the...; Region: Peptidase_S24_S26; cd06462
633149003747	Catalytic site [active]
633149003748	ASC-1 homology or ASCH domain, a small beta-barrel domain found in all three kingdoms of life. ASCH resembles the RNA-binding PUA domain and may also interact with RNA. ASCH has been proposed to function as an RNA-binding domain during coactivation; Region: ASCH; cl01020
633149003749	conjugative transfer relaxase protein TraI; Region: TraI_TIGR; TIGR02760
633149003750	transcriptional activator RfaH; Region: RfaH; TIGR01955
633149003751	N-Utilization Substance G (NusG) N-terminal (NGN) domain Superfamily; Region: NGN; cl02766
633149003752	Phage terminase large subunit (GpA); Region: Terminase_GpA; pfam05876
633149003753	gpW; Region: gpW; pfam02831
633149003754	phage portal protein, lambda family; Region: portal_lambda; TIGR01539
633149003755	Phage portal protein, lambda family; Region: Phage_portal_2; pfam05136
633149003756	Signal peptide peptidase A (SppA) 36K type, a serine protease, has catalytic Ser-Lys dyad; Region: S49_Sppa_36K_type; cd07022
633149003757	tandem repeat interface [polypeptide binding]; other site
633149003758	oligomer interface [polypeptide binding]; other site
633149003759	active site residues [active]
633149003760	Bacteriophage lambda head decoration protein D; Region: HDPD; pfam02924
633149003761	Phage major capsid protein E; Region: Phage_cap_E; pfam03864
633149003762	integrating conjugative element protein, PFL_4705 family; Region: conj_TIGR03752
633149003763	GDSL-like Lipase/Acylhydrolase family; Region: Lipase_GDSL_2; pfam13472
633149003764	active site
633149003765	oxyanion hole [active]
633149003766	catalytic triad [active]
633149003767	Integrase [DNA replication, recombination, and repair]; Region: XerC; COG0582
633149003768	DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182
633149003769	active site
633149003770	catalytic residues [active]
633149003771	DNA binding site [nucleotide binding]
633149003772	Int/Topo IB signature motif; other site
633149003773	D-alanyl-D-alanine carboxypeptidase; Region: Peptidase_M15_4; pfam13539
633149003774	Protein of unknown function (DUF1469); Region: DUF1469; pfam07332
633149003775	Site-specific DNA methylase [DNA replication, recombination, and repair]; Region: Dam; COG0338
633149003776	Protein of unknown function (DUF1013); Region: DUF1013; cl11533
633149003777	Beta/Gamma crystallin; Region: Crystall; pfam00030
633149003778	putative NAD(P)H quinone oxidoreductase, PIG3 family; Region: quinone_pig3; TIGR02824
633149003779	PIG3 p53-inducible quinone oxidoreductase; Region: p53_inducible_oxidoreductase; cd05276
633149003780	NAD(P) binding site [chemical binding]; other site
633149003781	Protein of unknown function (DUF1192); Region: DUF1192; pfam06698
633149003782	Protein of unknown function (DUF1465); Region: DUF1465; pfam07323
633149003783	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2989
633149003784	Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471
633149003785	L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734
633149003786	50S ribosomal protein L31; Reviewed; Region: rpmE; PRK00528
633149003787	ABC transporter, permease/ATP-binding protein; Region: MsbA_rel; TIGR02204
633149003788	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
633149003789	ATP-binding cassette domain of a mitochondrial protein MTABC3 and related proteins; Region: ABC_MTABC3_MDL1_MDL2; cd03249
633149003790	Walker A/P-loop; other site
633149003791	ATP binding site [chemical binding]; other site
633149003792	Q-loop/lid; other site
633149003793	ABC transporter signature motif; other site
633149003794	Walker B; other site
633149003795	D-loop; other site
633149003796	H-loop/switch region; other site
633149003797	Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584
633149003798	Catalytic domain of phosphoinositide-specific phospholipase C-like phosphodiesterases superfamily; Region: PI-PLCc_GDPD_SF; cl14615
633149003799	active site
633149003800	catalytic site [active]
633149003801	IMPase, inositol monophosphatase and related domains. A family of Mg++ dependent phosphatases, inhibited by lithium, many of which may act on inositol monophosphate substrate. They dephosphorylate inositol phosphate to generate inositol, which may be...; Region: IMPase; cd01639
633149003802	Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483
633149003803	active site
633149003804	dimerization interface [polypeptide binding]; other site
633149003805	elongation factor P; Validated; Region: PRK00529
633149003806	Elongation factor P (EF-P) KOW-like domain; Region: EFP_N; pfam08207
633149003807	S1_EF-P_repeat_1: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_1; cd04470
633149003808	RNA binding site [nucleotide binding]; other site
633149003809	S1_EF-P_repeat_2: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_2; cd05794
633149003810	RNA binding site [nucleotide binding]; other site
633149003811	TspO/MBR family; Region: TspO_MBR; cl01379
633149003812	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
633149003813	non-specific DNA binding site [nucleotide binding]; other site
633149003814	salt bridge; other site
633149003815	sequence-specific DNA binding site [nucleotide binding]; other site
633149003816	Protein of unknown function (DUF2975); Region: DUF2975; pfam11188
633149003817	ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131
633149003818	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
633149003819	Walker A/P-loop; other site
633149003820	ATP binding site [chemical binding]; other site
633149003821	Q-loop/lid; other site
633149003822	ABC transporter signature motif; other site
633149003823	Walker B; other site
633149003824	D-loop; other site
633149003825	H-loop/switch region; other site
633149003826	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4200
633149003827	ABC-2 family transporter protein; Region: ABC2_membrane_4; pfam12730
633149003828	Bacterioferritin (cytochrome b1) [Inorganic ion transport and metabolism]; Region: Bfr; COG2193
633149003829	Bacterioferritin, ferritin-like diiron-binding domain; Region: Bacterioferritin; cd00907
633149003830	heme binding site [chemical binding]; other site
633149003831	ferroxidase pore; other site
633149003832	ferroxidase diiron center [ion binding]; other site
633149003833	Bacterioferritin-associated ferredoxin [Inorganic ion transport and metabolism]; Region: Bfd; COG2906
633149003834	Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5-; Region: TMP_TenI; cd00564
633149003835	thiamine phosphate binding site [chemical binding]; other site
633149003836	active site
633149003837	pyrophosphate binding site [ion binding]; other site
633149003838	MASE1; Region: MASE1; cl17823
633149003839	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585
633149003840	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
633149003841	dimer interface [polypeptide binding]; other site
633149003842	phosphorylation site [posttranslational modification]
633149003843	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
633149003844	ATP binding site [chemical binding]; other site
633149003845	Mg2+ binding site [ion binding]; other site
633149003846	G-X-G motif; other site
633149003847	Bacterial Cytochrome Ubiquinol Oxidase; Region: Bac_Ubq_Cox; pfam01654
633149003848	Cytochrome oxidase subunit II; Region: Cyto_ox_2; pfam02322
633149003849	cytochrome d ubiquinol oxidase subunit 2; Provisional; Region: PRK15003; cl12219
633149003850	Flagellin N-methylase; Region: FliB; cl00497
633149003851	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
633149003852	N-terminal domain of Streptomyces griseus SgaA (suppression of growth disturbance caused by A-factor at a high concentration under high osmolality during early growth phase), and similar domains; Region: SgaA_N_like; cd07247
633149003853	Esterase/lipase [Lipid metabolism]; Region: Aes; COG0657
633149003854	Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326
633149003855	acetyl-CoA acetyltransferase; Provisional; Region: PRK06954
633149003856	Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751
633149003857	dimer interface [polypeptide binding]; other site
633149003858	active site
633149003859	Uncharacterized ACR, COG2135; Region: DUF159; pfam02586
633149003860	Thioesterase-like superfamily; Region: 4HBT_3; pfam13622
633149003861	Predicted transcriptional regulators [Transcription]; Region: COG1733
633149003862	HxlR-like helix-turn-helix; Region: HxlR; pfam01638
633149003863	Hemerythrin-like domain; Region: Hr-like; cd12108
633149003864	Fe binding site [ion binding]; other site
633149003865	Predicted tRNA(5-methylaminomethyl-2-thiouridylate) methyltransferase, contains the PP-loop ATPase domain [Translation, ribosomal structure and biogenesis]; Region: TrmU; COG0482
633149003866	tRNA methyl transferase. This family represents tRNA(5-methylaminomethyl-2-thiouridine)-methyltransferase which is involved in the biosynthesis of the modified nucleoside 5-methylaminomethyl-2-thiouridine present in the wobble position of some tRNAs; Region: tRNA_Me_trans; cd01998
633149003867	Ligand Binding Site [chemical binding]; other site
633149003868	Protein of unknown function (DUF1153); Region: DUF1153; pfam06627
633149003869	Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460
633149003870	flagellar hook protein FlgE; Validated; Region: flgE; PRK05682
633149003871	Flagellar basal body protein FlaE; Region: FlaE; pfam07559
633149003872	Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429
633149003873	Flagellar hook capping protein - N-terminal region; Region: FlgD; pfam03963
633149003874	FlgD Tudor-like domain; Region: FLgD_tudor; pfam13861
633149003875	Flagellar hook-length control protein FliK; Region: Flg_hook; pfam02120
633149003876	flagellar hook-associated protein FlgK; Region: flgK_ends; TIGR02492
633149003877	Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460
633149003878	Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429
633149003879	flagellar hook-associated protein 3; Region: flagell_flgL; TIGR02550
633149003880	Bacterial flagellin C-terminal helical region; Region: Flagellin_C; pfam00700
633149003881	Predicted DNA-binding protein with the Helix-hairpin-helix motif [General function prediction only]; Region: COG4277
633149003882	probable DNA metabolism protein; Region: SAM_7_link_chp; TIGR03915
633149003883	Family 4 Uracil-DNA glycosylase (UDG), found exclusively in thermophilic organisms; Region: UDG_F4_TTUDGA_like; cd10030
633149003884	Fe-S cluster binding site [ion binding]; other site
633149003885	active site
633149003886	ABC-type transport system involved in resistance to organic solvents, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2B; COG0767
633149003887	Permease; Region: Permease; pfam02405
633149003888	ABC-type transport system involved in resistance to organic solvents, ATPase component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2A; COG1127
633149003889	ATP-binding cassette transport system involved in resistant to organic solvents; Region: ABC_Org_Solvent_Resistant; cd03261
633149003890	Walker A/P-loop; other site
633149003891	ATP binding site [chemical binding]; other site
633149003892	Q-loop/lid; other site
633149003893	ABC transporter signature motif; other site
633149003894	Walker B; other site
633149003895	D-loop; other site
633149003896	H-loop/switch region; other site
633149003897	ABC-type transport system involved in resistance to organic solvents, periplasmic component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2C; COG1463
633149003898	mce related protein; Region: MCE; pfam02470
633149003899	Protein of unknown function (DUF330); Region: DUF330; cl01135
633149003900	cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664
633149003901	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
633149003902	ligand binding site [chemical binding]; other site
633149003903	flexible hinge region; other site
633149003904	Predicted esterase of the alpha-beta hydrolase superfamily [General function prediction only]; Region: RssA; COG1752
633149003905	Patatin-like phospholipase domain containing protein 6, protein 7, and fungal NTE1; Region: Pat_PNPLA6_PNPLA7_NTE1_like; cd07205
633149003906	active site
633149003907	nucleophile elbow; other site
633149003908	Plasmid stabilization system protein [General function prediction only]; Region: ParE; COG3668
633149003909	putative addiction module antidote protein, CC2985 family; Region: antidote_CC2985; TIGR02606
633149003910	Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872
633149003911	D-alanyl-D-alanine carboxypeptidase; Region: Peptidase_S11; pfam00768
633149003912	Phasin protein; Region: Phasin_2; cl11491
633149003913	ATP-dependent Clp protease adaptor protein ClpS; Reviewed; Region: clpS; PRK00033
633149003914	ATP-dependent Clp protease ATP-binding subunit clpA; Region: ClpA; TIGR02639
633149003915	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
633149003916	Walker A motif; other site
633149003917	ATP binding site [chemical binding]; other site
633149003918	Walker B motif; other site
633149003919	arginine finger; other site
633149003920	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
633149003921	Walker A motif; other site
633149003922	ATP binding site [chemical binding]; other site
633149003923	Walker B motif; other site
633149003924	C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431
633149003925	CsbD-like; Region: CsbD; pfam05532
633149003926	Membrane protein of unknown function; Region: DUF360; pfam04020
633149003927	glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650
633149003928	The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301
633149003929	Walker A/P-loop; other site
633149003930	ATP binding site [chemical binding]; other site
633149003931	Q-loop/lid; other site
633149003932	ABC transporter signature motif; other site
633149003933	Walker B; other site
633149003934	D-loop; other site
633149003935	H-loop/switch region; other site
633149003936	TOBE domain; Region: TOBE_2; pfam08402
633149003937	Acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta) [Lipid metabolism]; Region: COG4799
633149003938	malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682
633149003939	Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; cl17345
633149003940	Escherichia coli PhnB and similar proteins; the E. coli phnB gene is found next to an operon involved in the cleavage of carbon-phosphorus bonds in unactivated alkylphosphonates; Region: PhnB_like; cd06588
633149003941	dimer interface [polypeptide binding]; other site
633149003942	16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187
633149003943	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
633149003944	RNA binding surface [nucleotide binding]; other site
633149003945	Pseudouridine synthases catalyze the isomerization of specific uridines in an RNA molecule to pseudouridines (5-ribosyluracil, psi); Region: PseudoU_synth; cl00130
633149003946	active site
633149003947	Domain of unknown function (DUF336); Region: DUF336; pfam03928
633149003948	Protein of unknown function (DUF938); Region: DUF938; pfam06080
633149003949	Phosphoenolpyruvate carboxykinase (PEPCK), a critical gluconeogenic enzyme, catalyzes the first committed step in the diversion of tricarboxylic acid cycle intermediates toward gluconeogenesis. It catalyzes the reversible decarboxylation and...; Region: PEPCK_GTP; cd00819
633149003950	active site
633149003951	substrate-binding site [chemical binding]; other site
633149003952	metal-binding site [ion binding]
633149003953	GTP binding site [chemical binding]; other site
633149003954	glycine oxidase ThiO; Region: thiamin_ThiO; TIGR02352
633149003955	Gram-negative bacterial tonB protein; Region: TonB; pfam03544
633149003956	Lytic Transglycosylase (LT)  and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL).  LTs...; Region: LT_GEWL; cd00254
633149003957	N-acetyl-D-glucosamine binding site [chemical binding]; other site
633149003958	catalytic residue [active]
633149003959	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5330
633149003960	Uncharacterized protein conserved in bacteria (DUF2336); Region: DUF2336; pfam10098
633149003961	inorganic polyphosphate/ATP-NAD kinase; Reviewed; Region: ppnK; PRK04761
633149003962	Uncharacterized protein conserved in bacteria (DUF2336); Region: DUF2336; pfam10098
633149003963	aldolase II superfamily protein; Provisional; Region: PRK07044
633149003964	intersubunit interface [polypeptide binding]; other site
633149003965	active site
633149003966	Zn2+ binding site [ion binding]; other site
633149003967	RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730
633149003968	HlyD family secretion protein; Region: HlyD_3; pfam13437
633149003969	Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841
633149003970	FeoA domain; Region: FeoA; pfam04023
633149003971	Fe2+ transport system protein B [Inorganic ion transport and metabolism]; Region: FeoB; COG0370
633149003972	Ferrous iron transport protein B (FeoB) family; Region: FeoB; cd01879
633149003973	G1 box; other site
633149003974	GTP/Mg2+ binding site [chemical binding]; other site
633149003975	Switch I region; other site
633149003976	G2 box; other site
633149003977	G3 box; other site
633149003978	Switch II region; other site
633149003979	G4 box; other site
633149003980	G5 box; other site
633149003981	Nucleoside recognition; Region: Gate; pfam07670
633149003982	Ferrous iron transport protein B C terminus; Region: FeoB_C; pfam07664
633149003983	Nucleoside recognition; Region: Gate; pfam07670
633149003984	Type II secretory pathway, prepilin signal peptidase PulO and related peptidases [Cell motility and secretion / Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: PulO; COG1989
633149003985	Bacterial Peptidase A24 N-terminal domain; Region: DiS_P_DiS; pfam06750
633149003986	Type IV leader peptidase family; Region: Peptidase_A24; pfam01478
633149003987	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
633149003988	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
633149003989	bifunctional sulfate adenylyltransferase subunit 1/adenylylsulfate kinase protein; Provisional; Region: PRK05506
633149003990	CysN, together with protein CysD, forms the ATP sulfurylase (ATPS) complex; Region: CysN_ATPS; cd04166
633149003991	CysD dimerization site [polypeptide binding]; other site
633149003992	G1 box; other site
633149003993	putative GEF interaction site [polypeptide binding]; other site
633149003994	GTP/Mg2+ binding site [chemical binding]; other site
633149003995	Switch I region; other site
633149003996	G2 box; other site
633149003997	G3 box; other site
633149003998	Switch II region; other site
633149003999	G4 box; other site
633149004000	G5 box; other site
633149004001	CysN_NodQ_II: This subfamily represents the domain II of the large subunit of ATP sulfurylase (ATPS): CysN or the N-terminal portion of NodQ, found mainly in proteobacteria and homologous to the domain II of EF-Tu. Escherichia coli ATPS consists of CysN...; Region: CysN_NodQ_II; cd03695
633149004002	TCysN_NoDQ_II: This subfamily represents the domain II of the large subunit of ATP sulfurylase (ATPS): CysN or the N-terminal portion of NodQ, found mainly in proteobacteria and homologous to the domain II of EF-Tu. Escherichia coli ATPS consists of CysN...; Region: CysN_NoDQ_III; cd04095
633149004003	Adenosine 5'-phosphosulfate kinase (APSK) catalyzes the phosphorylation of adenosine 5'-phosphosulfate to form 3'-phosphoadenosine 5'-phosphosulfate (PAPS). The end-product PAPS is a biologically "activated" sulfate form...; Region: APSK; cd02027
633149004004	ligand-binding site [chemical binding]; other site
633149004005	sulfate adenylyltransferase, small subunit; Region: CysD; TIGR02039
633149004006	This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713
633149004007	Active Sites [active]
633149004008	DNA-binding transcriptional activator GcvA; Provisional; Region: PRK11139
633149004009	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
633149004010	The C-terminal substrate domain of LysR-type GcdR, TrPI, HvR and beta-lactamase regulators, and that of other closely related homologs; contains the type 2 periplasmic binding fold; Region: PBP2_GcdR_TrpI_HvrB_AmpR_like; cd08432
633149004011	dimerization interface [polypeptide binding]; other site
633149004012	substrate binding pocket [chemical binding]; other site
633149004013	siroheme synthase; Provisional; Region: cysG; PRK10637
633149004014	Putative NAD(P)-binding; Region: NAD_binding_7; pfam13241
633149004015	Sirohaem synthase dimerisation region; Region: CysG_dimeriser; pfam10414
633149004016	Uroporphyrin-III C-methyltransferase (S-Adenosyl-L-methionine:uroporphyrinogen III methyltransferase, SUMT); Region: SUMT; cd11642
633149004017	active site
633149004018	SAM binding site [chemical binding]; other site
633149004019	homodimer interface [polypeptide binding]; other site
633149004020	Protein of unknown function (DUF2849); Region: DUF2849; pfam11011
633149004021	Sulfite reductase, beta subunit (hemoprotein) [Inorganic ion transport and metabolism]; Region: CysI; COG0155
633149004022	Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460
633149004023	Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460
633149004024	Bacterial protein of unknown function (DUF934); Region: DUF934; cl01526
633149004025	3'-phosphoadenosine 5'-phosphosulfate sulfotransferase (PAPS reductase)/FAD synthetase and related enzymes [Amino acid transport and metabolism / Coenzyme metabolism]; Region: CysH; COG0175
633149004026	This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713
633149004027	Active Sites [active]
633149004028	Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031
633149004029	CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561
633149004030	dimer interface [polypeptide binding]; other site
633149004031	pyridoxal 5'-phosphate binding site [chemical binding]; other site
633149004032	catalytic residue [active]
633149004033	Protein of unknown function, DUF486; Region: DUF486; cl01236
633149004034	HINT (histidine triad nucleotide-binding protein) subgroup: Members of this CD belong to the superfamily of histidine triad hydrolases that act on alpha-phosphate of ribonucleotides. This subgroup includes members from all three forms of cellular life; Region: HINT_subgroup; cd01277
633149004035	HIT family signature motif; other site
633149004036	catalytic residue [active]
633149004037	Domain amino terminal to FKBP-type peptidyl-prolyl isomerase; Region: FKBP_N; pfam01346
633149004038	FKBP-type peptidyl-prolyl cis-trans isomerases 1 [Posttranslational modification, protein turnover, chaperones]; Region: FkpA; COG0545
633149004039	FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254
633149004040	Predicted RNA polymerase sigma factor containing a TPR repeat domain [Transcription]; Region: COG4941
633149004041	Sigma-70, region 4; Region: Sigma70_r4_2; pfam08281
633149004042	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3795
633149004043	Protein of unknown function (DUF2807); Region: DUF2807; pfam10988
633149004044	30S ribosomal protein S10; Reviewed; Region: rpsJ; PRK00596
633149004045	50S ribosomal protein L3; Validated; Region: rplC; PRK00001
633149004046	50S ribosomal protein L4; Provisional; Region: rplD; PRK05319
633149004047	50S ribosomal protein L23; Reviewed; Region: rplW; PRK05738
633149004048	50S ribosomal protein L2; Validated; Region: rplB; PRK09374
633149004049	Ribosomal Proteins L2, RNA binding domain; Region: Ribosomal_L2; pfam00181
633149004050	Ribosomal Proteins L2, C-terminal domain; Region: Ribosomal_L2_C; pfam03947
633149004051	30S ribosomal protein S19; Reviewed; Region: rpsS; PRK00357
633149004052	Ribosomal protein L22/L17e.  L22 (L17 in eukaryotes) is a core protein of the large ribosomal subunit.  It is the only ribosomal protein that interacts with all six domains of 23S rRNA, and is one of the proteins important for directing the proper...; Region: Ribosomal_L22; cd00336
633149004053	putative translocon binding site; other site
633149004054	protein-rRNA interface [nucleotide binding]; other site
633149004055	30S ribosomal protein S3; Reviewed; Region: rpsC; PRK00310
633149004056	K homology RNA-binding (KH) domain of the prokaryotic 30S small ribosomal subunit protein S3. S3  is part of the head region of the 30S ribosomal subunit and is believed to interact with mRNA as it threads its way from the latch into the channel.  The KH...; Region: 30S_S3_KH; cd02412
633149004057	G-X-X-G motif; other site
633149004058	Ribosomal protein S3, C-terminal domain; Region: Ribosomal_S3_C; pfam00189
633149004059	Ribosomal_L16_L10e: L16 is an essential protein in the large ribosomal subunit of bacteria, mitochondria, and chloroplasts. Large subunits that lack L16 are defective in peptidyl transferase activity, peptidyl-tRNA hydrolysis activity, association with...; Region: Ribosomal_L16_L10e; cd01433
633149004060	23S rRNA interface [nucleotide binding]; other site
633149004061	5S rRNA interface [nucleotide binding]; other site
633149004062	putative antibiotic binding site [chemical binding]; other site
633149004063	L25 interface [polypeptide binding]; other site
633149004064	L27 interface [polypeptide binding]; other site
633149004065	Ribosomal L29 protein/HIP.  L29 is a protein of the large ribosomal Subunit. A homolog, called heparin/heparan sulfate interacting protein (HIP), has also been identified in mammals.  L29 is located on the surface of the large ribosomal subunit, where it...; Region: Ribosomal_L29_HIP; cd00427
633149004066	23S rRNA interface [nucleotide binding]; other site
633149004067	putative translocon interaction site; other site
633149004068	signal recognition particle (SRP54) interaction site; other site
633149004069	L23 interface [polypeptide binding]; other site
633149004070	trigger factor interaction site; other site
633149004071	30S ribosomal protein S17; Reviewed; Region: rpsQ; PRK05610
633149004072	50S ribosomal protein L14; Validated; Region: rplN; PRK05483
633149004073	50S ribosomal protein L24; Reviewed; Region: rplX; PRK00004
633149004074	KOW motif of Ribosomal Protein L26; Region: KOW_RPL26; cd06089
633149004075	RNA binding site [nucleotide binding]; other site
633149004076	50S ribosomal protein L5; Validated; Region: rplE; PRK00010
633149004077	Ribosomal protein L5; Region: Ribosomal_L5; pfam00281
633149004078	ribosomal L5P family C-terminus; Region: Ribosomal_L5_C; pfam00673
633149004079	30S ribosomal protein S14; Reviewed; Region: rpsN; PRK08881
633149004080	30S ribosomal protein S8; Validated; Region: rpsH; PRK00136
633149004081	50S ribosomal protein L6; Validated; Region: rplF; PRK05498
633149004082	Ribosomal protein L6; Region: Ribosomal_L6; pfam00347
633149004083	Ribosomal protein L6; Region: Ribosomal_L6; pfam00347
633149004084	Ribosomal L18/L5e:  L18 (L5e) is a ribosomal protein found in the central protuberance (CP) of the large subunit. L18 binds 5S rRNA and induces a conformational change that stimulates the binding of L5 to 5S rRNA. Association of 5S rRNA with 23S rRNA...; Region: Ribosomal_L18_L5e; cd00432
633149004085	23S rRNA interface [nucleotide binding]; other site
633149004086	L21e interface [polypeptide binding]; other site
633149004087	5S rRNA interface [nucleotide binding]; other site
633149004088	L27 interface [polypeptide binding]; other site
633149004089	L5 interface [polypeptide binding]; other site
633149004090	30S ribosomal protein S5; Validated; Region: rpsE; PRK00550
633149004091	Ribosomal protein S5, N-terminal domain; Region: Ribosomal_S5; pfam00333
633149004092	Ribosomal protein S5, C-terminal domain; Region: Ribosomal_S5_C; pfam03719
633149004093	Ribosomal protein L30, which is found in eukaryotes and prokaryotes but not in archaea, is one of the smallest ribosomal proteins with a molecular mass of about 7kDa. L30 binds the 23SrRNA as well as the 5S rRNA and is one of five ribosomal proteins that...; Region: Ribosomal_L30; cd01658
633149004094	23S rRNA binding site [nucleotide binding]; other site
633149004095	50S ribosomal protein L15; Reviewed; Region: rplO; PRK05592
633149004096	preprotein translocase subunit SecY; Reviewed; Region: secY; PRK09204
633149004097	SecY translocase; Region: SecY; pfam00344
633149004098	adenylate kinase; Provisional; Region: PRK14532
633149004099	Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for...; Region: ADK; cd01428
633149004100	AMP-binding site [chemical binding]; other site
633149004101	ATP-AMP (Ap5A)-binding site [chemical binding]; other site
633149004102	Ribosomal protein S13 [Translation, ribosomal structure and biogenesis]; Region: RpsM; COG0099
633149004103	30S ribosomal protein S13; Region: bact_S13; TIGR03631
633149004104	30S ribosomal protein S11; Validated; Region: PRK05309
633149004105	DNA-directed RNA polymerase subunit alpha; Provisional; Region: PRK05182
633149004106	N-terminal domain of the Alpha subunit of Bacterial RNA polymerase; Region: RNAP_alpha_NTD; cd06928
633149004107	alphaNTD - beta interaction site [polypeptide binding]; other site
633149004108	alphaNTD homodimer interface [polypeptide binding]; other site
633149004109	alphaNTD - beta' interaction site [polypeptide binding]; other site
633149004110	Bacterial RNA polymerase, alpha chain C terminal domain; Region: RNA_pol_A_CTD; pfam03118
633149004111	50S ribosomal protein L17; Validated; Region: rplQ; PRK05591
633149004112	Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583
633149004113	Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625
633149004114	Glutathione S-transferase (GST) family, N-terminal domain; a large, diverse group of cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of  glutathione (GSH) with a wide range of endogenous and xenobiotic...; Region: GST_N_family; cd00570
633149004115	C-terminal domain interface [polypeptide binding]; other site
633149004116	GSH binding site (G-site) [chemical binding]; other site
633149004117	dimer interface [polypeptide binding]; other site
633149004118	C-terminal, alpha helical domain of the Glutathione S-transferase family; Region: GST_C_family; cl02776
633149004119	N-terminal domain interface [polypeptide binding]; other site
633149004120	Caseinolytic protease (ClpP) is an ATP-dependent protease; Region: Clp_protease_like; cl15763
633149004121	active site
633149004122	ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131
633149004123	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
633149004124	Walker A/P-loop; other site
633149004125	ATP binding site [chemical binding]; other site
633149004126	Q-loop/lid; other site
633149004127	ABC transporter signature motif; other site
633149004128	Walker B; other site
633149004129	D-loop; other site
633149004130	H-loop/switch region; other site
633149004131	Peptidase M10 serralysin C terminal; Region: Peptidase_M10_C; pfam08548
633149004132	Peptidase M10 serralysin C terminal; Region: Peptidase_M10_C; pfam08548
633149004133	Peptidase M10 serralysin C terminal; Region: Peptidase_M10_C; pfam08548
633149004134	Lysophospholipase L1-like subgroup of SGNH-hydrolases. The best characterized member in this family is TesA, an E. coli periplasmic protein with thioesterase, esterase, arylesterase, protease and lysophospholipase activity; Region: Lysophospholipase_L1_like; cd01822
633149004135	active site
633149004136	catalytic triad [active]
633149004137	oxyanion hole [active]
633149004138	switch loop; other site
633149004139	phosphonoacetate hydrolase; Region: hydr_PhnA; TIGR02335
633149004140	Type I phosphodiesterase / nucleotide pyrophosphatase; Region: Phosphodiest; pfam01663
633149004141	periplasmic serine protease, Do/DeqQ family; Region: degP_htrA_DO; TIGR02037
633149004142	Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365
633149004143	PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987
633149004144	protein binding site [polypeptide binding]; other site
633149004145	PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987
633149004146	protein binding site [polypeptide binding]; other site
633149004147	This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_8; cd07246
633149004148	putative dimer interface [polypeptide binding]; other site
633149004149	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
633149004150	recombination factor protein RarA; Reviewed; Region: PRK13342
633149004151	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
633149004152	Walker A motif; other site
633149004153	ATP binding site [chemical binding]; other site
633149004154	Walker B motif; other site
633149004155	arginine finger; other site
633149004156	MgsA AAA+ ATPase C terminal; Region: MgsA_C; pfam12002
633149004157	Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564
633149004158	Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869
633149004159	active site
633149004160	Predicted membrane protein (DUF2214); Region: DUF2214; cl01427
633149004161	camphor resistance protein CrcB; Provisional; Region: PRK14195
633149004162	Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564
633149004163	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cl09940
633149004164	RNA binding surface [nucleotide binding]; other site
633149004165	Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869
633149004166	active site
633149004167	Predicted phosphatases [General function prediction only]; Region: Gph; COG0546
633149004168	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
633149004169	motif II; other site
633149004170	ATP12 chaperone protein; Region: ATP12; cl02228
633149004171	Superfamily II DNA and RNA helicases [DNA replication, recombination, and repair / Transcription / Translation, ribosomal structure and biogenesis]; Region: SrmB; COG0513
633149004172	DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker  B motif; Region: DEADc; cd00268
633149004173	ATP binding site [chemical binding]; other site
633149004174	Mg++ binding site [ion binding]; other site
633149004175	motif III; other site
633149004176	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
633149004177	nucleotide binding region [chemical binding]; other site
633149004178	ATP-binding site [chemical binding]; other site
633149004179	RNA recognition motif in the DbpA subfamily of prokaryotic DEAD-box rRNA helicases; Region: RRM_DbpA; cd12252
633149004180	RNA binding site [nucleotide binding]; other site
633149004181	Bacterial pre-peptidase C-terminal domain; Region: PPC; pfam04151
633149004182	Caspase domain; Region: Peptidase_C14; pfam00656
633149004183	phenylpropionate dioxygenase ferredoxin reductase subunit; Provisional; Region: PRK09754
633149004184	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
633149004185	GST_N family, Class Zeta subfamily; GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of endogenous and xenobiotic alkylating agents, including carcinogens; Region: GST_N_Zeta; cd03042
633149004186	maleylacetoacetate isomerase; Region: maiA; TIGR01262
633149004187	C-terminal domain interface [polypeptide binding]; other site
633149004188	GSH binding site (G-site) [chemical binding]; other site
633149004189	putative dimer interface [polypeptide binding]; other site
633149004190	C-terminal, alpha helical domain of Class Zeta Glutathione S-transferases; Region: GST_C_Zeta; cd03191
633149004191	dimer interface [polypeptide binding]; other site
633149004192	N-terminal domain interface [polypeptide binding]; other site
633149004193	maleylacetoacetate (MAA) substrate binding site (H site) [chemical binding]; other site
633149004194	2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179
633149004195	Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557
633149004196	Antibiotic biosynthesis monooxygenase; Region: ABM; pfam03992
633149004197	Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301
633149004198	Sodium:dicarboxylate symporter family; Region: SDF; pfam00375
633149004199	Short-chain dehydrogenase involved in D-alanine esterification of lipoteichoic acid and wall teichoic acid (D-alanine transfer protein) [Cell envelope biogenesis, outer membrane]; Region: DltE; COG3967
633149004200	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
633149004201	NAD(P) binding site [chemical binding]; other site
633149004202	active site
633149004203	Predicted transcriptional regulators [Transcription]; Region: COG1733
633149004204	HxlR-like helix-turn-helix; Region: HxlR; pfam01638
633149004205	phosphoglycolate phosphatase; Provisional; Region: PRK13222
633149004206	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
633149004207	motif II; other site
633149004208	bifunctional N-acetylglucosamine-1-phosphate uridyltransferase/glucosamine-1-phosphate acetyltransferase; Provisional; Region: glmU; PRK14353
633149004209	N-terminal domain of bacterial GlmU; Region: GT2_GlmU_N_bac; cd02540
633149004210	Substrate binding site; other site
633149004211	Mg++ binding site; other site
633149004212	N-acetyl-glucosamine-1-phosphate uridyltransferase (GlmU), C-terminal left-handed beta-helix (LbH) acetyltransferase domain: GlmU is also known as UDP-N-acetylglucosamine pyrophosphorylase. It is a bifunctional bacterial enzyme that catalyzes two...; Region: LbH_GlmU_C; cd03353
633149004213	active site
633149004214	substrate binding site [chemical binding]; other site
633149004215	CoA binding site [chemical binding]; other site
633149004216	RPI_A: Ribose 5-phosphate isomerase type A (RPI_A) subfamily; RPI catalyzes the reversible conversion of ribose-5-phosphate to ribulose 5-phosphate, the first step of the non-oxidative branch of the pentose phosphate pathway. This reaction leads to the...; Region: RPI_A; cd01398
633149004217	tetramer (dimer of dimers) interface [polypeptide binding]; other site
633149004218	active site
633149004219	dimer interface [polypeptide binding]; other site
633149004220	glutathione reductase; Validated; Region: PRK06116
633149004221	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
633149004222	Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852
633149004223	Class-II DAHP synthetase family; Region: DAHP_synth_2; pfam01474
633149004224	Prephenate dehydratase; Region: PDT; pfam00800
633149004225	Chorismate mutase [Amino acid transport and metabolism]; Region: PheA; COG1605
633149004226	pantoate--beta-alanine ligase; Region: panC; TIGR00018
633149004227	Pantoate-beta-alanine ligase; Region: PanC; cd00560
633149004228	active site
633149004229	ATP-binding site [chemical binding]; other site
633149004230	pantoate-binding site; other site
633149004231	HXXH motif; other site
633149004232	ATPase MipZ; Region: MipZ; pfam09140
633149004233	ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042
633149004234	P-loop; other site
633149004235	Magnesium ion binding site [ion binding]; other site
633149004236	ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042
633149004237	Magnesium ion binding site [ion binding]; other site
633149004238	DnaJ domain or J-domain.  DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cl02542
633149004239	HSP70 interaction site [polypeptide binding]; other site
633149004240	3-methylcrotonyl-CoA carboxylase, beta chain; Region: PLN02820
633149004241	Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; cl17345
633149004242	Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; cl17345
633149004243	Uncharacterized protein conserved in bacteria (DUF2200); Region: DUF2200; pfam09966
633149004244	enoyl-CoA hydratase; Provisional; Region: PRK05995
633149004245	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
633149004246	substrate binding site [chemical binding]; other site
633149004247	oxyanion hole (OAH) forming residues; other site
633149004248	trimer interface [polypeptide binding]; other site
633149004249	Acetyl/propionyl-CoA carboxylase, alpha subunit [Lipid metabolism]; Region: COG4770
633149004250	Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289
633149004251	ATP-grasp domain; Region: ATP-grasp_4; cl17255
633149004252	Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878
633149004253	The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850
633149004254	carboxyltransferase (CT) interaction site; other site
633149004255	biotinylation site [posttranslational modification]; other site
633149004256	Protein of unknown function (DUF1489); Region: DUF1489; pfam07370
633149004257	Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534
633149004258	Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Vibrio cholerae NorM; Region: MATE_NorM_like; cd13131
633149004259	cation binding site [ion binding]; other site
633149004260	methionyl-tRNA synthetase; Reviewed; Region: PRK12268
633149004261	catalytic core domain of methioninyl-tRNA synthetases; Region: MetRS_core; cd00814
633149004262	active site
633149004263	HIGH motif; other site
633149004264	KMSKS motif; other site
633149004265	Anticodon-binding domain of methionyl tRNA synthetases; Region: Anticodon_Ia_Met; cd07957
633149004266	tRNA binding surface [nucleotide binding]; other site
633149004267	anticodon binding site; other site
633149004268	integral membrane protein, YjbE family; Region: R_switched_YjbE; TIGR03717
633149004269	rRNA methylase, putative, group 3; Region: rRNA_methyl_3; TIGR00186
633149004270	RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; pfam08032
633149004271	SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588
633149004272	elongation factor Tu; Reviewed; Region: PRK00049
633149004273	Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884
633149004274	G1 box; other site
633149004275	GEF interaction site [polypeptide binding]; other site
633149004276	GTP/Mg2+ binding site [chemical binding]; other site
633149004277	Switch I region; other site
633149004278	G2 box; other site
633149004279	G3 box; other site
633149004280	Switch II region; other site
633149004281	G4 box; other site
633149004282	G5 box; other site
633149004283	EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697
633149004284	Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707
633149004285	Antibiotic Binding Site [chemical binding]; other site
633149004286	Protein involved in cellulose biosynthesis (CelD) [Cell envelope biogenesis, outer membrane]; Region: COG5653
633149004287	Acetyltransferase (GNAT) domain; Region: Acetyltransf_6; pfam13480
633149004288	Cupin-like domain; Region: Cupin_8; pfam13621
633149004289	DNA-directed RNA polymerase subunit beta; Reviewed; Region: rpoB; PRK00405
633149004290	RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cl17585
633149004291	RNA polymerase Rpb2, domain 2; Region: RNA_pol_Rpb2_2; pfam04561
633149004292	RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653
633149004293	RNA polymerase Rpb2, domain 6; Region: RNA_pol_Rpb2_6; pfam00562
633149004294	RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653
633149004295	RPB1 interaction site [polypeptide binding]; other site
633149004296	RPB11 interaction site [polypeptide binding]; other site
633149004297	RPB10 interaction site [polypeptide binding]; other site
633149004298	RPB3 interaction site [polypeptide binding]; other site
633149004299	RNA polymerase Rpb1, domain 1; Region: RNA_pol_Rpb1_1; pfam04997
633149004300	DNA-directed RNA polymerase, beta' subunit/160 kD subunit [Transcription]; Region: RpoC; COG0086
633149004301	RNA polymerase I subunit A N-terminus; Region: RPOLA_N; smart00663
633149004302	RNA polymerase Rpb1, domain 3; Region: RNA_pol_Rpb1_3; pfam04983
633149004303	RNA polymerase Rpb1, domain 4; Region: RNA_pol_Rpb1_4; pfam05000
633149004304	RNA polymerase Rpb1, domain 5; Region: RNA_pol_Rpb1_5; pfam04998
633149004305	Largest subunit of RNA polymerase (RNAP), C-terminal domain; Region: RNAP_largest_subunit_C; cl11429
633149004306	Rpb1 - Rpb6 interaction site [polypeptide binding]; other site
633149004307	Largest subunit (beta') of Bacterial DNA-dependent RNA polymerase (RNAP), C-terminal domain; Region: RNAP_beta'_C; cd02655
633149004308	DNA binding site [nucleotide binding]
633149004309	Rpb1 (beta') - Rpb2 (beta) interaction site [polypeptide binding]; other site
633149004310	Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447
633149004311	nudix motif; other site
633149004312	This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632
633149004313	active site
633149004314	metal binding site [ion binding]; metal-binding site
633149004315	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
633149004316	ribonuclease R; Region: RNase_R; TIGR02063
633149004317	RNB domain; Region: RNB; pfam00773
633149004318	S1_RNase_R: RNase R C-terminal S1 domain. RNase R is a processive 3' to 5' exoribonuclease, which is a homolog of RNase II. RNase R degrades RNA with secondary structure having a 3' overhang of at least 7 nucleotides. RNase R and PNPase...; Region: S1_RNase_R; cd04471
633149004319	RNA binding site [nucleotide binding]; other site
633149004320	Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031
633149004321	CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561
633149004322	dimer interface [polypeptide binding]; other site
633149004323	pyridoxal 5'-phosphate binding site [chemical binding]; other site
633149004324	catalytic residue [active]
633149004325	FOG: CBS domain [General function prediction only]; Region: COG0517
633149004326	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the pyridoxal-phosphate (PALP) dependent enzyme domain upstream.   The vitamin B6 complex comprises pyridoxine, pyridoxal, and pyridoxamine, as well...; Region: CBS_pair_PALP_assoc2; cd04609
633149004327	Cys/Met metabolism PLP-dependent enzyme; Region: Cys_Met_Meta_PP; pfam01053
633149004328	CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614
633149004329	homodimer interface [polypeptide binding]; other site
633149004330	substrate-cofactor binding pocket; other site
633149004331	pyridoxal 5'-phosphate binding site [chemical binding]; other site
633149004332	catalytic residue [active]
633149004333	Secreted and surface protein containing fasciclin-like repeats [Cell envelope biogenesis, outer membrane]; Region: COG2335
633149004334	Fasciclin domain; Region: Fasciclin; pfam02469
633149004335	Bacterial protein of unknown function (Gcw_chp); Region: Gcw_chp; cl09901
633149004336	Dioxygenases related to 2-nitropropane dioxygenase [General function prediction only]; Region: COG2070
633149004337	2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730
633149004338	FMN binding site [chemical binding]; other site
633149004339	substrate binding site [chemical binding]; other site
633149004340	putative catalytic residue [active]
633149004341	7-cyano-7-deazaguanine reductase; Provisional; Region: PRK13258
633149004342	GIY-YIG domain of LuxR and ArsR family transcriptional regulators, and uncharacterized hypothetical proteins found in bacteria; Region: GIY-YIG_LuxR_like; cd10451
633149004343	GIY-YIG motif/motif A; other site
633149004344	Uncharacterized protein conserved in bacteria (DUF2239); Region: DUF2239; pfam09998
633149004345	Uncharacterized protein family UPF0027; Region: UPF0027; pfam01139
633149004346	hypothetical protein; Reviewed; Region: PRK09588
633149004347	Protein of unknown function (DUF817); Region: DUF817; pfam05675
633149004348	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
633149004349	S-adenosylmethionine binding site [chemical binding]; other site
633149004350	Nitroreductase-like family which includes NADH oxidase and arsenite oxidiase. NADH oxidase catalyses the oxidation of NAD(P)H and accepts a wide broad range of compounds as electron acceptors, such as nitrocompound. Arsenite oxidase in a...; Region: Arsenite_oxidase; cd02135
633149004351	putative FMN binding site [chemical binding]; other site
633149004352	ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424
633149004353	ADP-ribose binding site [chemical binding]; other site
633149004354	dimer interface [polypeptide binding]; other site
633149004355	active site
633149004356	nudix motif; other site
633149004357	metal binding site [ion binding]; metal-binding site
633149004358	serine acetyltransferase; Provisional; Region: cysE; PRK11132
633149004359	Serine acetyltransferase, N-terminal; Region: SATase_N; pfam06426
633149004360	Serine acetyltransferase (SAT): SAT catalyzes the CoA-dependent acetylation of the side chain hydroxyl group of L-serine to form O-acetylserine, as the first step of a two-step biosynthetic pathway in bacteria and plants leading to the formation of...; Region: LbH_SAT; cd03354
633149004361	trimer interface [polypeptide binding]; other site
633149004362	active site
633149004363	substrate binding site [chemical binding]; other site
633149004364	CoA binding site [chemical binding]; other site
633149004365	Protein of unknown function (DUF3126); Region: DUF3126; pfam11324
633149004366	Ribosomal protein L11 methylase [Translation, ribosomal structure and biogenesis]; Region: PrmA; COG2264
633149004367	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
633149004368	S-adenosylmethionine binding site [chemical binding]; other site
633149004369	Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321
633149004370	Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006
633149004371	X-Prolyl Aminopeptidase 2. E.C. 3.4.11.9. Also known as X-Pro aminopeptidase, proline aminopeptidase, aminopeptidase P, and aminoacylproline aminopeptidase. Catalyses release of any N-terminal amino acid, including proline, that is linked with proline; Region: APP; cd01085
633149004372	active site
633149004373	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
633149004374	Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248
633149004375	active site
633149004376	catalytic tetrad [active]
633149004377	Uncharacterized protein conserved in bacteria (DUF2147); Region: DUF2147; pfam09917
633149004378	Ligase N family; Region: LIGANc; smart00532
633149004379	NAD+ dependent DNA ligase adenylation domain. DNA ligases catalyze the crucial step of joining the breaks in duplex DNA during DNA replication, repair and recombination, utilizing either ATP or NAD(+) as a cofactor, but using the same basic reaction...; Region: LIGANc; cd00114
633149004380	nucleotide binding pocket [chemical binding]; other site
633149004381	K-X-D-G motif; other site
633149004382	catalytic site [active]
633149004383	NAD-dependent DNA ligase OB-fold domain; Region: DNA_ligase_OB; pfam03120
633149004384	NAD-dependent DNA ligase C4 zinc finger domain; Region: DNA_ligase_ZBD; pfam03119
633149004385	Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo...; Region: BRCT; cd00027
633149004386	Dimer interface [polypeptide binding]; other site
633149004387	BRCT sequence motif; other site
633149004388	M28 Zn-Peptidases; Region: M28_like_2; cd05662
633149004389	Peptidase family M28; Region: Peptidase_M28; pfam04389
633149004390	metal binding site [ion binding]; metal-binding site
633149004391	Putative protein-S-isoprenylcysteine methyltransferase [Posttranslational modification, protein turnover, chaperones]; Region: STE14; COG2020
633149004392	cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the...; Region: cyclophilin; cd00317
633149004393	active site
633149004394	23S rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: FtsJ; COG0293
633149004395	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
633149004396	S-adenosylmethionine binding site [chemical binding]; other site
633149004397	Predicted membrane protein (DUF2061); Region: DUF2061; cl01257
633149004398	Predicted membrane protein (DUF2061); Region: DUF2061; pfam09834
633149004399	inosine 5'-monophosphate dehydrogenase; Reviewed; Region: PRK05567
633149004400	TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186
633149004401	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in the inosine 5' monophosphate dehydrogenase (IMPDH) protein.  IMPDH is an essential enzyme that catalyzes the first step unique to GTP synthesis, playing a...; Region: CBS_pair_IMPDH; cd04601
633149004402	IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381
633149004403	active site
633149004404	MAPEG family; Region: MAPEG; cl09190
633149004405	NOL1/NOP2/sun family; Region: Nol1_Nop2_Fmu; pfam01189
633149004406	NOL1/NOP2/sun family putative RNA methylase; Region: nop2p; TIGR00446
633149004407	5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase; Validated; Region: PRK06026
633149004408	5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase, putative; Region: MTA/SAH-nuc-hyp; TIGR01705
633149004409	Protein of unknown function (DUF1311); Region: DUF1311; pfam07007
633149004410	GMP synthase; Reviewed; Region: guaA; PRK00074
633149004411	Type 1 glutamine amidotransferase (GATase1) domain found in GMP synthetase; Region: GATase1_GMP_Synthase; cd01742
633149004412	AMP/PPi binding site [chemical binding]; other site
633149004413	candidate oxyanion hole; other site
633149004414	catalytic triad [active]
633149004415	potential glutamine specificity residues [chemical binding]; other site
633149004416	The C-terminal domain of GMP synthetase. It contains two subdomains; the ATP pyrophosphatase domain which closes to the N-termial and the dimerization domain at C-terminal end. The ATP-PPase is a twisted, five-stranded parallel beta-sheet sandwiched...; Region: GMP_synthase_C; cd01997
633149004417	ATP Binding subdomain [chemical binding]; other site
633149004418	Ligand Binding sites [chemical binding]; other site
633149004419	Dimerization subdomain; other site
633149004420	integrase; Provisional; Region: PRK09692
633149004421	Bacteriophage P4 integrase. P4-like integrases are found in temperate bacteriophages, integrative plasmids, pathogenicity and symbiosis islands, and other mobile genetic elements.  They share the same fold in their catalytic domain and the overall...; Region: INT_P4; cd00801
633149004422	active site
633149004423	Int/Topo IB signature motif; other site
633149004424	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
633149004425	DNA-binding site [nucleotide binding]; DNA binding site
633149004426	stationary phase growth adaptation protein; Provisional; Region: PRK09717
633149004427	Prophage CP4-57 regulatory protein (AlpA); Region: Phage_AlpA; pfam05930
633149004428	Protein of unknown function (DUF3800); Region: DUF3800; pfam12686
633149004429	ParB-like nuclease domain; Region: ParBc; pfam02195
633149004430	SnoaL-like domain; Region: SnoaL_2; pfam12680
633149004431	Helix-Turn-Helix DNA binding domain of the CadR- and PbrR-like transcription regulators; Region: HTH_CadR-PbrR-like; cd04785
633149004432	DNA binding residues [nucleotide binding]
633149004433	zinc-responsive transcriptional regulator; Provisional; Region: zntR; PRK09514
633149004434	dimer interface [polypeptide binding]; other site
633149004435	putative metal binding site [ion binding]; other site
633149004436	Co/Zn/Cd efflux system component [Inorganic ion transport and metabolism]; Region: CzcD; COG1230
633149004437	Outer membrane protein [Cell envelope biogenesis, outer membrane / Intracellular trafficking and secretion]; Region: TolC; COG1538
633149004438	Membrane Fusion Protein cluster 2 (function with RND porters); Region: 8a0102; TIGR00999
633149004439	HlyD family secretion protein; Region: HlyD_3; pfam13437
633149004440	heavy metal efflux pump, CzcA family; Region: 2A0601; TIGR00914
633149004441	Co/Zn/Cd efflux system component [Inorganic ion transport and metabolism]; Region: CzcD; COG1230
633149004442	heavy metal translocating P-type ATPase; Region: ATPase-IB_hvy; TIGR01525
633149004443	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
633149004444	Soluble P-type ATPase [General function prediction only]; Region: COG4087
633149004445	Domain of unknown function (DUF305); Region: DUF305; cl17794
633149004446	Predicted acyltransferases [Lipid metabolism]; Region: COG1835
633149004447	Protein of unknown function, DUF; Region: DUF411; cl01142
633149004448	DNA Polymerase IV/Kappa; Region: PolY_Pol_IV_kappa; cd03586
633149004449	active site
633149004450	DNA polymerase IV; Validated; Region: PRK02406
633149004451	DNA binding site [nucleotide binding]
633149004452	CopC domain; Region: CopC; cl01012
633149004453	Copper resistance protein B precursor (CopB); Region: CopB; pfam05275
633149004454	copper-resistance protein, CopA family; Region: copper_res_A; TIGR01480
633149004455	Multicopper oxidase; Region: Cu-oxidase_3; pfam07732
633149004456	Multicopper oxidase; Region: Cu-oxidase; pfam00394
633149004457	Multicopper oxidase; Region: Cu-oxidase_2; pfam07731
633149004458	RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937
633149004459	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
633149004460	Sigma-70, region 4; Region: Sigma70_r4_2; pfam08281
633149004461	DNA binding residues [nucleotide binding]
633149004462	CpxP component of the bacterial Cpx-two-component system and related proteins; Region: CpxP_like; cd09916
633149004463	dimer interface [polypeptide binding]; other site
633149004464	CopC domain; Region: CopC; pfam04234
633149004465	Uncharacterized conserved protein [Function unknown]; Region: COG3350
633149004466	Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217
633149004467	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
633149004468	Transcriptional regulators CsoR (copper-sensitive operon repressor), RcnR, and FrmR, and related domains; this domain superfamily was previously known as DUF156; Region: CsoR-like_DUF156; cd10148
633149004469	putative homodimer interface [polypeptide binding]; other site
633149004470	putative homotetramer interface [polypeptide binding]; other site
633149004471	putative allosteric switch controlling residues; other site
633149004472	putative metal binding site [ion binding]; other site
633149004473	putative homodimer-homodimer interface [polypeptide binding]; other site
633149004474	Domain of unknown function (DUF305); Region: DUF305; cl17794
633149004475	SnoaL-like domain; Region: SnoaL_3; pfam13474
633149004476	haemagglutination activity domain; Region: Haemagg_act; smart00912
633149004477	Hemolysin activation/secretion protein [Intracellular trafficking and secretion]; Region: FhaC; COG2831
633149004478	POTRA domain, ShlB-type; Region: POTRA_2; pfam08479
633149004479	Surface antigen; Region: Bac_surface_Ag; pfam01103
633149004480	Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804
633149004481	CoA-transferase family III; Region: CoA_transf_3; pfam02515
633149004482	Alpha amylase catalytic domain found in Amylosucrase; Region: AmyAc_Amylosucrase; cd11324
633149004483	trehalose synthase; Region: treS_nterm; TIGR02456
633149004484	active site
633149004485	catalytic site [active]
633149004486	Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940
633149004487	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037
633149004488	Fucose permease [Carbohydrate transport and metabolism]; Region: FucP; COG0738
633149004489	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
633149004490	putative substrate translocation pore; other site
633149004491	Transcriptional regulators [Transcription]; Region: PurR; COG1609
633149004492	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
633149004493	DNA binding site [nucleotide binding]
633149004494	domain linker motif; other site
633149004495	Ligand binding domain of a transcription regulator of cellulose genes, CelR, which is highly homologous to the LacI-GalR family of bacterial transcription regulators; Region: PBP1_CelR; cd06295
633149004496	putative dimerization interface [polypeptide binding]; other site
633149004497	putative ligand binding site [chemical binding]; other site
633149004498	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244
633149004499	Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629
633149004500	glucuronate isomerase; Reviewed; Region: PRK02925
633149004501	Glucuronate isomerase [Carbohydrate transport and metabolism]; Region: UxaC; COG1904
633149004502	Mannitol-1-phosphate/altronate dehydrogenases [Carbohydrate transport and metabolism]; Region: MtlD; COG0246
633149004503	Mannitol dehydrogenase Rossmann domain; Region: Mannitol_dh; pfam01232
633149004504	Mannitol dehydrogenase C-terminal domain; Region: Mannitol_dh_C; pfam08125
633149004505	Biopolymer transport protein [Intracellular trafficking and secretion]; Region: ExbD; COG0848
633149004506	Biopolymer transport protein ExbD/TolR; Region: ExbD; cl00537
633149004507	GTP cyclohydrolase I; Provisional; Region: folE; PRK09347
633149004508	GTP cyclohydrolase I; Provisional; Region: PLN03044
633149004509	active site
633149004510	cysteinyl-tRNA synthetase; Validated; Region: cysS; PRK00260
633149004511	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
633149004512	active site
633149004513	HIGH motif; other site
633149004514	nucleotide binding site [chemical binding]; other site
633149004515	catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672
633149004516	KMSKS motif; other site
633149004517	Anticodon-binding domain of cysteinyl tRNA synthetases; Region: Anticodon_Ia_Cys; cd07963
633149004518	tRNA binding surface [nucleotide binding]; other site
633149004519	anticodon binding site; other site
633149004520	Transglycosylase SLT domain; Region: SLT_2; pfam13406
633149004521	murein hydrolase B; Provisional; Region: PRK10760; cl17906
633149004522	Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471
633149004523	Predicted acyltransferases [Lipid metabolism]; Region: COG1835
633149004524	Domain of unknown function (DU1801); Region: DUF1801; pfam08818
633149004525	Predicted transcriptional regulator [Transcription]; Region: COG2378
633149004526	WYL domain; Region: WYL; pfam13280
633149004527	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
633149004528	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
633149004529	non-specific DNA binding site [nucleotide binding]; other site
633149004530	salt bridge; other site
633149004531	sequence-specific DNA binding site [nucleotide binding]; other site
633149004532	Predicted transcriptional regulator [General function prediction only]; Region: COG3800
633149004533	Domain of unknown function (DUF955); Region: DUF955; pfam06114
633149004534	Predicted transcriptional regulator (DUF2083); Region: DUF2083; pfam09856
633149004535	isocitrate lyase; Provisional; Region: PRK15063
633149004536	Members of the ICL/PEPM enzyme family catalyze either P-C or C-C bond formation/cleavage. Known members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate hydrolase (OAH), isocitrate...; Region: ICL_PEPM; cd00377
633149004537	tetramer interface [polypeptide binding]; other site
633149004538	active site
633149004539	Mg2+/Mn2+ binding site [ion binding]; other site
633149004540	MHYT domain (predicted integral membrane sensor domain) [Signal transduction mechanisms]; Region: COG3300
633149004541	Bacterial signalling protein N terminal repeat; Region: MHYT; pfam03707
633149004542	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
633149004543	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
633149004544	dimer interface [polypeptide binding]; other site
633149004545	phosphorylation site [posttranslational modification]
633149004546	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
633149004547	ATP binding site [chemical binding]; other site
633149004548	Mg2+ binding site [ion binding]; other site
633149004549	G-X-G motif; other site
633149004550	Response regulator receiver domain; Region: Response_reg; pfam00072
633149004551	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
633149004552	active site
633149004553	phosphorylation site [posttranslational modification]
633149004554	intermolecular recognition site; other site
633149004555	dimerization interface [polypeptide binding]; other site
633149004556	PAS domain; Region: PAS_8; pfam13188
633149004557	phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966
633149004558	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
633149004559	dimer interface [polypeptide binding]; other site
633149004560	phosphorylation site [posttranslational modification]
633149004561	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
633149004562	ATP binding site [chemical binding]; other site
633149004563	Mg2+ binding site [ion binding]; other site
633149004564	G-X-G motif; other site
633149004565	Phosphate ATP-binding cassette transporter; Region: DUF3708; pfam12501
633149004566	ABC-type phosphate transport system, permease component [Inorganic ion transport and metabolism]; Region: PstC; COG0573
633149004567	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
633149004568	dimer interface [polypeptide binding]; other site
633149004569	conserved gate region; other site
633149004570	putative PBP binding loops; other site
633149004571	ABC-ATPase subunit interface; other site
633149004572	Domain of unknown function (DUF3333); Region: DUF3333; pfam11812
633149004573	ABC-type phosphate transport system, permease component [Inorganic ion transport and metabolism]; Region: PstA; COG0581
633149004574	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
633149004575	dimer interface [polypeptide binding]; other site
633149004576	conserved gate region; other site
633149004577	putative PBP binding loops; other site
633149004578	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427
633149004579	ABC-ATPase subunit interface; other site
633149004580	phosphate transporter ATP-binding protein; Provisional; Region: PRK14235
633149004581	ATP-binding cassette domain of the phosphate transport system; Region: ABC_PstB_phosphate_transporter; cd03260
633149004582	Walker A/P-loop; other site
633149004583	ATP binding site [chemical binding]; other site
633149004584	Q-loop/lid; other site
633149004585	ABC transporter signature motif; other site
633149004586	Walker B; other site
633149004587	D-loop; other site
633149004588	H-loop/switch region; other site
633149004589	phosphate transport system regulatory protein PhoU; Region: phoU_full; TIGR02135
633149004590	PhoU domain; Region: PhoU; pfam01895
633149004591	PhoU domain; Region: PhoU; pfam01895
633149004592	phosphate regulon transcriptional regulatory protein PhoB; Region: PhoB; TIGR02154
633149004593	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
633149004594	active site
633149004595	phosphorylation site [posttranslational modification]
633149004596	intermolecular recognition site; other site
633149004597	dimerization interface [polypeptide binding]; other site
633149004598	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
633149004599	DNA binding site [nucleotide binding]
633149004600	Protein of unknown function, DUF399; Region: DUF399; cl01139
633149004601	Heat shock protein 33 (Hsp33):  Cytosolic protein that acts as a molecular chaperone under oxidative conditions.  In normal (reducing) cytosolic conditions, four conserved Cys residues are coordinated by a Zn ion. Under oxidative stress (such as heat...; Region: Hsp33; cd00498
633149004602	Hsp33-like chaperonin; Reviewed; Region: hslO; PRK00114
633149004603	dimerization interface [polypeptide binding]; other site
633149004604	domain crossover interface; other site
633149004605	redox-dependent activation switch; other site
633149004606	short chain dehydrogenase; Provisional; Region: PRK07109
633149004607	classical (c) SDR, subgroup 3; Region: SDR_c3; cd05360
633149004608	putative NAD(P) binding site [chemical binding]; other site
633149004609	active site
633149004610	phosphoserine phosphatase SerB; Region: serB; TIGR00338
633149004611	haloacid dehalogenase-like hydrolase; Region: HAD; cl17202
633149004612	D-3-phosphoglycerate dehydrogenase; Provisional; Region: PRK11790
633149004613	Phosphoglycerate dehydrogenases, NAD-binding and catalytic domains; Region: PGDH_3; cd12176
633149004614	ligand binding site [chemical binding]; other site
633149004615	NAD binding site [chemical binding]; other site
633149004616	tetramer interface [polypeptide binding]; other site
633149004617	catalytic site [active]
633149004618	C-terminal ACT (regulatory) domain of D-3-Phosphoglycerate Dehydrogenase (3PGDH) found in fungi and bacteria; Region: ACT_3PGDH; cd04901
633149004619	L-serine binding site [chemical binding]; other site
633149004620	ACT domain interface; other site
633149004621	Fatty acyltransferase-like subfamily of the SGNH hydrolases, a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its...; Region: fatty_acyltransferase_like; cd01846
633149004622	active site
633149004623	catalytic triad [active]
633149004624	oxyanion hole [active]
633149004625	Autotransporter beta-domain; Region: Autotransporter; smart00869
633149004626	S1_IF1: Translation Initiation Factor IF1, S1-like RNA-binding domain. IF1 contains an S1-like RNA-binding domain, which is found in a wide variety of RNA-associated proteins. Translation initiation includes a number of interrelated steps preceding the...; Region: S1_IF1; cd04451
633149004627	rRNA binding site [nucleotide binding]; other site
633149004628	predicted 30S ribosome binding site; other site
633149004629	Maf-like protein; Region: Maf; pfam02545
633149004630	Nucleotide binding protein Maf. Maf has been implicated in inhibition of septum formation in eukaryotes, bacteria and archaea, but homologs in B.subtilis and S.cerevisiae are nonessential for cell division. Maf has been predicted to be a nucleotide- or...; Region: Maf; cd00555
633149004631	active site
633149004632	dimer interface [polypeptide binding]; other site
633149004633	S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927
633149004634	RNA binding site [nucleotide binding]; other site
633149004635	Domain of unknown function (DUF329); Region: DUF329; cl01144
633149004636	MotA/TolQ/ExbB proton channel family; Region: MotA_ExbB; cl00568
633149004637	Biopolymer transport protein [Intracellular trafficking and secretion]; Region: ExbD; COG0848
633149004638	Biopolymer transport protein ExbD/TolR; Region: ExbD; cl00537
633149004639	Gram-negative bacterial tonB protein; Region: TonB; pfam03544
633149004640	3-oxoacid CoA-transferase, B subunit; Region: pcaJ_scoB_fam; TIGR02428
633149004641	Uncharacterized homolog of gamma-carboxymuconolactone decarboxylase subunit [Function unknown]; Region: COG0599
633149004642	Acyl CoA:acetate/3-ketoacid CoA transferase, alpha subunit [Lipid metabolism]; Region: AtoD; COG1788
633149004643	Protein of unknown function (DUF1365); Region: DUF1365; pfam07103
633149004644	Predicted NAD/FAD-binding protein [General function prediction only]; Region: COG2907
633149004645	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
633149004646	Cyclopropane fatty acid synthase and related methyltransferases [Cell envelope biogenesis, outer membrane]; Region: Cfa; COG2230
633149004647	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
633149004648	S-adenosylmethionine binding site [chemical binding]; other site
633149004649	Predicted membrane protein (DUF2177); Region: DUF2177; pfam09945
633149004650	SGNH_peri2; putative periplasmic member of the SGNH-family of hydrolases, a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known...; Region: SGNH_hydrolase_peri2; cd01829
633149004651	active site
633149004652	catalytic triad [active]
633149004653	oxyanion hole [active]
633149004654	SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cl01053
633149004655	active site
633149004656	catalytic triad [active]
633149004657	oxyanion hole [active]
633149004658	Predicted membrane protein involved in D-alanine export [Cell envelope biogenesis, outer membrane]; Region: DltB; COG1696
633149004659	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4102
633149004660	Protein of unknown function (DUF1800); Region: DUF1800; pfam08811
633149004661	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
633149004662	SCP-2 sterol transfer family; Region: SCP2; pfam02036
633149004663	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
633149004664	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
633149004665	active site
633149004666	ergothioneine biosynthesis protein EgtB; Region: egtB_TIGR03440
633149004667	Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; pfam03781
633149004668	dimethylhistidine N-methyltransferase; Region: egtD_ergothio; TIGR03438
633149004669	Methyltransferase domain; Region: Methyltransf_25; pfam13649
633149004670	Uncharacterized conserved protein (DUF2260); Region: DUF2260; pfam10017
633149004671	General stress protein [General function prediction only]; Region: GsiB; COG3729
633149004672	Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491
633149004673	trigger factor; Provisional; Region: tig; PRK01490
633149004674	FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254
633149004675	Bacterial trigger factor protein (TF) C-terminus; Region: Trigger_C; pfam05698
633149004676	Protease subunit of ATP-dependent Clp proteases [Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: ClpP; COG0740
633149004677	Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017
633149004678	oligomer interface [polypeptide binding]; other site
633149004679	active site residues [active]
633149004680	haloacid dehalogenase-like hydrolase; Region: HAD; cl17202
633149004681	haloacid dehalogenase-like hydrolase; Region: Hydrolase; pfam00702
633149004682	ATP-dependent protease ATP-binding subunit ClpX; Provisional; Region: clpX; PRK05342
633149004683	ClpX C4-type zinc finger; Region: zf-C4_ClpX; pfam06689
633149004684	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
633149004685	Walker A motif; other site
633149004686	ATP binding site [chemical binding]; other site
633149004687	Walker B motif; other site
633149004688	C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086
633149004689	ATP-dependent Lon protease, bacterial type [Posttranslational modification, protein turnover, chaperones]; Region: Lon; COG0466
633149004690	Found in ATP-dependent protease La (LON); Region: LON; smart00464
633149004691	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
633149004692	Walker A motif; other site
633149004693	ATP binding site [chemical binding]; other site
633149004694	Walker B motif; other site
633149004695	arginine finger; other site
633149004696	Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362
633149004697	Domain of unknown function (DUF4129); Region: DUF4129; pfam13559
633149004698	Domain of unknown function (DUF4350); Region: DUF4350; pfam14258
633149004699	MoxR-like ATPases [General function prediction only]; Region: COG0714
633149004700	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
633149004701	Walker A motif; other site
633149004702	ATP binding site [chemical binding]; other site
633149004703	Walker B motif; other site
633149004704	arginine finger; other site
633149004705	Uncharacterized conserved protein (some members contain a von Willebrand factor type A (vWA) domain) [General function prediction only]; Region: COG1721
633149004706	Protein of unknown function DUF58; Region: DUF58; pfam01882
633149004707	Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198
633149004708	metal ion-dependent adhesion site (MIDAS); other site
633149004709	Uncharacterized membrane protein [Function unknown]; Region: SpoIIM; COG1300
633149004710	Predicted membrane protein/domain [Function unknown]; Region: COG1714
633149004711	Escherichia coli YegD, a putative chaperone protein, and related proteins; Region: YegD_like; cd10231
633149004712	putative chaperone; Provisional; Region: PRK11678
633149004713	nucleotide binding site [chemical binding]; other site
633149004714	putative NEF/HSP70 interaction site [polypeptide binding]; other site
633149004715	SBD interface [polypeptide binding]; other site
633149004716	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
633149004717	Major Facilitator Superfamily; Region: MFS_1; pfam07690
633149004718	putative substrate translocation pore; other site
633149004719	Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629
633149004720	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244
633149004721	Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629
633149004722	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244
633149004723	Transcriptional regulators [Transcription]; Region: PurR; COG1609
633149004724	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
633149004725	DNA binding site [nucleotide binding]
633149004726	domain linker motif; other site
633149004727	Ligand-binding domain of DNA transcription repressor SalR, a member of the LacI-GalR family of bacterial transcription regulators; Region: PBP1_SalR; cd01545
633149004728	putative dimerization interface [polypeptide binding]; other site
633149004729	putative ligand binding site [chemical binding]; other site
633149004730	Beta-glucosidase-related glycosidases [Carbohydrate transport and metabolism]; Region: BglX; COG1472
633149004731	Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; pfam00933
633149004732	Glycosyl hydrolase family 3 C-terminal domain; Region: Glyco_hydro_3_C; pfam01915
633149004733	Laminarinase, member of the glycosyl hydrolase family 16; Region: GH16_laminarinase_like; cd08023
633149004734	active site
633149004735	catalytic residues [active]
633149004736	enoyl-CoA hydratase; Provisional; Region: PRK06142
633149004737	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
633149004738	substrate binding site [chemical binding]; other site
633149004739	oxyanion hole (OAH) forming residues; other site
633149004740	trimer interface [polypeptide binding]; other site
633149004741	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
633149004742	TPR motif; other site
633149004743	binding surface
633149004744	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
633149004745	TPR motif; other site
633149004746	binding surface
633149004747	Putative 2OG-Fe(II) oxygenase; Region: 2OG-FeII_Oxy_5; pfam13759
633149004748	2OG-Fe(II) oxygenase superfamily; Region: 2OG-FeII_Oxy_3; pfam13640
633149004749	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244
633149004750	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244
633149004751	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
633149004752	DNA binding residues [nucleotide binding]
633149004753	dimerization interface [polypeptide binding]; other site
633149004754	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
633149004755	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
633149004756	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
633149004757	DNA binding residues [nucleotide binding]
633149004758	dimerization interface [polypeptide binding]; other site
633149004759	Autotransporter beta-domain; Region: Autotransporter; smart00869
633149004760	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
633149004761	This family is most closely related to the GT1 family of glycosyltransferases. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can...; Region: GT1_like_2; cd03814
633149004762	Response regulator containing a CheY-like receiver domain and a GGDEF domain [Signal transduction mechanisms]; Region: PleD; COG3706
633149004763	Class III nucleotidyl cyclases; Region: Nucleotidyl_cyc_III; cl11967
633149004764	metal binding site [ion binding]; metal-binding site
633149004765	nucleotidyl binding site; other site
633149004766	Virulence factor BrkB; Region: Virul_fac_BrkB; pfam03631
633149004767	SirA, YedF, and YeeD. Two-layered alpha/beta sandwich domain.  SirA (also known as UvrY,  and YhhP) belongs to a family of bacterial two-component response regulators that controls secondary metabolism and virulence. The other member of this...; Region: SirA_YedF_YeeD; cd00291
633149004768	CPxP  motif; other site
633149004769	Competence-damaged protein; Region: CinA; pfam02464
633149004770	bifunctional 2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase/2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase protein; Provisional; Region: ispDF; PRK09382
633149004771	CDP-ME synthetase is involved in mevalonate-independent isoprenoid production; Region: CDP-ME_synthetase; cd02516
633149004772	substrate binding site; other site
633149004773	dimer interface; other site
633149004774	MECDP_synthase (2-C-methyl-D-erythritol-2,4-cyclodiphosphate synthase), encoded by the ispF gene, catalyzes the formation of 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (MEC) in the non-mevalonate deoxyxylulose (DOXP) pathway for isoprenoid biosynthesis; Region: MECDP_synthase; cd00554
633149004775	homotrimer interaction site [polypeptide binding]; other site
633149004776	zinc binding site [ion binding]; other site
633149004777	CDP-binding sites; other site
633149004778	putative TIM-barrel protein, nifR3 family; Region: nifR3_yhdG; TIGR00737
633149004779	Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801
633149004780	FMN binding site [chemical binding]; other site
633149004781	active site
633149004782	catalytic residues [active]
633149004783	substrate binding site [chemical binding]; other site
633149004784	Signal transduction histidine kinase involved in nitrogen fixation and metabolism regulation [Signal transduction mechanisms]; Region: NtrY; COG5000
633149004785	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
633149004786	dimerization interface [polypeptide binding]; other site
633149004787	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
633149004788	putative active site [active]
633149004789	heme pocket [chemical binding]; other site
633149004790	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
633149004791	dimer interface [polypeptide binding]; other site
633149004792	phosphorylation site [posttranslational modification]
633149004793	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
633149004794	ATP binding site [chemical binding]; other site
633149004795	Mg2+ binding site [ion binding]; other site
633149004796	G-X-G motif; other site
633149004797	Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204
633149004798	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
633149004799	active site
633149004800	phosphorylation site [posttranslational modification]
633149004801	intermolecular recognition site; other site
633149004802	dimerization interface [polypeptide binding]; other site
633149004803	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
633149004804	Walker A motif; other site
633149004805	ATP binding site [chemical binding]; other site
633149004806	Walker B motif; other site
633149004807	arginine finger; other site
633149004808	Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954
633149004809	Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115
633149004810	D-Alanine aminotransferase (D-AAT_like): D-amino acid aminotransferase catalyzes transamination between D-amino acids and their respective alpha-keto acids. It plays a major role in the synthesis of bacterial cell wall components like D-alanine and...; Region: D-AAT_like; cd01558
633149004811	homodimer interface [polypeptide binding]; other site
633149004812	substrate-cofactor binding pocket; other site
633149004813	pyridoxal 5'-phosphate binding site [chemical binding]; other site
633149004814	catalytic residue [active]
633149004815	bacterial Hfq-like; Region: Hfq; cd01716
633149004816	hexamer interface [polypeptide binding]; other site
633149004817	Sm1 motif; other site
633149004818	RNA binding site [nucleotide binding]; other site
633149004819	Sm2 motif; other site
633149004820	GTP-binding protein HflX; Region: GTP_HflX; TIGR03156
633149004821	GTP-binding GTPase N-terminal; Region: GTP-bdg_N; pfam13167
633149004822	HflX GTPase family; Region: HflX; cd01878
633149004823	G1 box; other site
633149004824	GTP/Mg2+ binding site [chemical binding]; other site
633149004825	Switch I region; other site
633149004826	G2 box; other site
633149004827	G3 box; other site
633149004828	Switch II region; other site
633149004829	G4 box; other site
633149004830	G5 box; other site
633149004831	50S ribosomal protein L33; Validated; Region: rpmG; PRK00595
633149004832	S12-like family, 30S ribosomal protein S12 subfamily; S12 is located at the interface of the large and small ribosomal subunits of prokaryotes, chloroplasts and mitochondria, where it plays an important role in both tRNA and ribosomal subunit...; Region: Ribosomal_S12; cd03368
633149004833	S17 interaction site [polypeptide binding]; other site
633149004834	S8 interaction site; other site
633149004835	16S rRNA interaction site [nucleotide binding]; other site
633149004836	streptomycin interaction site [chemical binding]; other site
633149004837	23S rRNA interaction site [nucleotide binding]; other site
633149004838	aminoacyl-tRNA interaction site (A-site) [nucleotide binding]; other site
633149004839	30S ribosomal protein S7; Validated; Region: PRK05302
633149004840	elongation factor G; Reviewed; Region: PRK00007
633149004841	Elongation factor G (EF-G) family involved in both the elongation and ribosome recycling phases of protein synthesis; Region: EF-G; cd01886
633149004842	G1 box; other site
633149004843	putative GEF interaction site [polypeptide binding]; other site
633149004844	GTP/Mg2+ binding site [chemical binding]; other site
633149004845	Switch I region; other site
633149004846	G2 box; other site
633149004847	G3 box; other site
633149004848	Switch II region; other site
633149004849	G4 box; other site
633149004850	G5 box; other site
633149004851	EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088
633149004852	EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434
633149004853	EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G.  Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713
633149004854	elongation factor Tu; Reviewed; Region: PRK00049
633149004855	Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884
633149004856	G1 box; other site
633149004857	GEF interaction site [polypeptide binding]; other site
633149004858	GTP/Mg2+ binding site [chemical binding]; other site
633149004859	Switch I region; other site
633149004860	G2 box; other site
633149004861	G3 box; other site
633149004862	Switch II region; other site
633149004863	G4 box; other site
633149004864	G5 box; other site
633149004865	EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697
633149004866	Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707
633149004867	Antibiotic Binding Site [chemical binding]; other site
633149004868	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
633149004869	dimer interface [polypeptide binding]; other site
633149004870	Methyl-accepting chemotaxis protein (MCP) signalling domain; Region: MCPsignal; pfam00015
633149004871	putative CheW interface [polypeptide binding]; other site
633149004872	Carboxylesterase family; Region: COesterase; pfam00135
633149004873	Esterases and lipases (includes fungal lipases, cholinesterases, etc.)  These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312
633149004874	substrate binding pocket [chemical binding]; other site
633149004875	catalytic triad [active]
633149004876	Putative peptidoglycan-binding domain-containing protein [Cell envelope biogenesis, outer membrane]; Region: COG3409
633149004877	Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471
633149004878	Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376
633149004879	L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734
633149004880	Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253
633149004881	Domain of unknown function DUF21; Region: DUF21; pfam01595
633149004882	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590
633149004883	Transporter associated domain; Region: CorC_HlyC; smart01091
633149004884	SecE/Sec61-gamma subunits of protein translocation complex; Region: SecE; pfam00584
633149004885	transcription antitermination protein NusG; Validated; Region: nusG; PRK05609
633149004886	Bacterial N-Utilization Substance G (NusG) N-terminal (NGN) domain, subgroup 1; Region: NGN_Bact_1; cd09891
633149004887	putative homodimer interface [polypeptide binding]; other site
633149004888	NusG contains an NGN domain at its N-terminus and KOW motif at its C-terminus; Region: KOW_NusG; cd06091
633149004889	heterodimer interface [polypeptide binding]; other site
633149004890	homodimer interface [polypeptide binding]; other site
633149004891	50S ribosomal protein L11; Validated; Region: rplK; PRK00140
633149004892	Ribosomal protein L11. Ribosomal protein L11, together with proteins L10 and L7/L12, and 23S rRNA, form the L7/L12 stalk on the surface of the large subunit of the ribosome. The homologous eukaryotic cytoplasmic protein is also called 60S ribosomal...; Region: Ribosomal_L11; cd00349
633149004893	23S rRNA interface [nucleotide binding]; other site
633149004894	L7/L12 interface [polypeptide binding]; other site
633149004895	putative thiostrepton binding site; other site
633149004896	L25 interface [polypeptide binding]; other site
633149004897	Ribosomal protein L1.  The L1 protein, located near the E-site of the ribosome, forms part of the L1 stalk along with 23S rRNA.  In bacteria and archaea, L1 functions both as a ribosomal protein that binds rRNA, and as a translation repressor that binds...; Region: Ribosomal_L1; cd00403
633149004898	mRNA/rRNA interface [nucleotide binding]; other site
633149004899	Uncharacterized protein conserved in bacteria (DUF2059); Region: DUF2059; pfam09832
633149004900	Ribosomal protein L10 family, L10 subfamily; composed of bacterial 50S ribosomal protein and eukaryotic mitochondrial 39S ribosomal protein, L10. L10 occupies the L7/L12 stalk of the ribosome. The N-terminal domain (NTD) of L10 interacts with L11 protein...; Region: Ribosomal_L10; cd05797
633149004901	23S rRNA interface [nucleotide binding]; other site
633149004902	Interface with L7/L12 ribosomal proteins [polypeptide binding]; other site
633149004903	Ribosomal protein L7/L12. Ribosomal protein L7/L12 refers to the large ribosomal subunit proteins L7 and L12, which are identical except that L7 is acetylated at the N terminus. It is a component of the L7/L12 stalk, which is located at the surface of...; Region: Ribosomal_L7_L12; cd00387
633149004904	core dimer interface [polypeptide binding]; other site
633149004905	peripheral dimer interface [polypeptide binding]; other site
633149004906	L10 interface [polypeptide binding]; other site
633149004907	L11 interface [polypeptide binding]; other site
633149004908	putative EF-Tu interaction site [polypeptide binding]; other site
633149004909	putative EF-G interaction site [polypeptide binding]; other site
633149004910	Putative intracellular protease/amidase [General function prediction only]; Region: ThiJ; COG0693
633149004911	Type 1 glutamine amidotransferase (GATase1)-like domain found in proteins similar to Escherichia coli Hsp31 protein; Region: GATase1_Hsp31_like; cd03141
633149004912	potential catalytic triad [active]
633149004913	conserved cys residue [active]
633149004914	Predicted protease with the C-terminal PDZ domain [General function prediction only]; Region: COG3975
633149004915	M61 glycyl aminopeptidase; Region: Peptidase_M61; pfam05299
633149004916	PDZ domain, also called DHR (Dlg homologous region) or GLGF (after a conserved sequence motif). Many PDZ domains bind C-terminal polypeptides, though binding to internal (non-C-terminal) polypeptides and even to lipids has been demonstrated; Region: PDZ; cl00117
633149004917	protein binding site [polypeptide binding]; other site
633149004918	Alanine racemase [Cell envelope biogenesis, outer membrane]; Region: Alr; COG0787
633149004919	Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Alanine Racemase; Region: PLPDE_III_AR; cd00430
633149004920	active site
633149004921	pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site
633149004922	dimer interface [polypeptide binding]; other site
633149004923	substrate binding site [chemical binding]; other site
633149004924	catalytic residues [active]
633149004925	glutamyl-tRNA synthetase; Provisional; Region: PRK12558
633149004926	catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808
633149004927	HIGH motif; other site
633149004928	catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808
633149004929	active site
633149004930	KMSKS motif; other site
633149004931	Possible lysine decarboxylase; Region: Lysine_decarbox; pfam03641
633149004932	hypothetical protein; Provisional; Region: PRK08912
633149004933	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
633149004934	pyridoxal 5'-phosphate binding site [chemical binding]; other site
633149004935	homodimer interface [polypeptide binding]; other site
633149004936	catalytic residue [active]
633149004937	rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566
633149004938	SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588
633149004939	Protein-L-isoaspartate carboxylmethyltransferase [Posttranslational modification, protein turnover, chaperones]; Region: Pcm; COG2518
633149004940	type I secretion outer membrane protein, TolC family; Region: type_I_sec_TolC; TIGR01844
633149004941	Protein of unknown function (DUF2497); Region: DUF2497; pfam10691
633149004942	valyl-tRNA synthetase; Reviewed; Region: valS; PRK05729
633149004943	catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817
633149004944	HIGH motif; other site
633149004945	Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603
633149004946	catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817
633149004947	active site
633149004948	KMSKS motif; other site
633149004949	Anticodon-binding domain of valyl tRNA synthetases; Region: Anticodon_Ia_Val; cd07962
633149004950	tRNA binding surface [nucleotide binding]; other site
633149004951	anticodon binding site; other site
633149004952	Valyl tRNA synthetase tRNA binding arm; Region: Val_tRNA-synt_C; pfam10458
633149004953	Uncharacterized conserved protein [Function unknown]; Region: COG2128
633149004954	Carboxymuconolactone decarboxylase family; Region: CMD; pfam02627
633149004955	Transcriptional regulator [Transcription]; Region: LysR; COG0583
633149004956	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
633149004957	The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422
633149004958	putative effector binding pocket; other site
633149004959	dimerization interface [polypeptide binding]; other site
633149004960	Predicted rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: COG1189
633149004961	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
633149004962	RNA binding surface [nucleotide binding]; other site
633149004963	FtsJ-like methyltransferase; Region: FtsJ; pfam01728
633149004964	SAM-dependent methyltransferases related to tRNA (uracil-5-)-methyltransferase [Translation, ribosomal structure and biogenesis]; Region: TrmA; COG2265
633149004965	DNA repair photolyase [DNA replication, recombination, and repair]; Region: SplB; COG1533
633149004966	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
633149004967	FeS/SAM binding site; other site
633149004968	Domain of unknown function, appears to be related to a diverse group of endonucleases; Region: Endonuclease_DUF559; cd01038
633149004969	putative active site [active]
633149004970	DNA topoisomerase I subunit omega; Validated; Region: PRK07561
633149004971	TOPRIM_TopoIA_TopoI: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to Escherichia coli DNA topoisomerase I.   Type IA DNA topoisomerases remove (relax) negative supercoils in the...; Region: TOPRIM_TopoIA_TopoI; cd03363
633149004972	active site
633149004973	interdomain interaction site; other site
633149004974	putative metal-binding site [ion binding]; other site
633149004975	nucleotide binding site [chemical binding]; other site
633149004976	DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186
633149004977	domain I; other site
633149004978	DNA binding groove [nucleotide binding]
633149004979	phosphate binding site [ion binding]; other site
633149004980	domain II; other site
633149004981	domain III; other site
633149004982	nucleotide binding site [chemical binding]; other site
633149004983	catalytic site [active]
633149004984	domain IV; other site
633149004985	Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396
633149004986	Topoisomerase C-terminal repeat; Region: Toprim_C_rpt; pfam13368
633149004987	Topoisomerase C-terminal repeat; Region: Toprim_C_rpt; pfam13368
633149004988	Topoisomerase C-terminal repeat; Region: Toprim_C_rpt; pfam13368
633149004989	Predicted Rossmann fold nucleotide-binding protein involved in DNA uptake [DNA replication, recombination, and repair / Intracellular trafficking and secretion]; Region: Smf; COG0758
633149004990	DNA protecting protein DprA; Region: dprA; TIGR00732
633149004991	putative glycerol-3-phosphate acyltransferase PlsY; Provisional; Region: PRK00220
633149004992	Glycerophosphodiester phosphodiesterase domain of Agrobacterium tumefaciens and similar proteins; Region: GDPD_AtGDE_like; cd08566
633149004993	Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584
633149004994	putative active site [active]
633149004995	catalytic site [active]
633149004996	putative metal binding site [ion binding]; other site
633149004997	oligomer interface [polypeptide binding]; other site
633149004998	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
633149004999	dihydroorotase; Validated; Region: PRK09059
633149005000	Dihydroorotase (DHOase), subgroup IIa; DHOases catalyze the reversible interconversion of carbamoyl aspartate to dihydroorotate, a key reaction in pyrimidine biosynthesis. This subgroup also contains proteins that lack the active site, like unc-33, a C; Region: DHOase_IIa; cd01317
633149005001	active site
633149005002	aspartate carbamoyltransferase catalytic subunit; Provisional; Region: pyrB; PRK00856
633149005003	Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729
633149005004	Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185
633149005005	Predicted permeases [General function prediction only]; Region: COG0679
633149005006	Uncharacterized protein family (UPF0081); Region: UPF0081; pfam03652
633149005007	aspartyl/glutamyl-tRNA amidotransferase subunit C; Reviewed; Region: gatC; PRK00034
633149005008	Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154
633149005009	aspartyl/glutamyl-tRNA amidotransferase subunit A; Reviewed; Region: gatA; PRK00012
633149005010	aspartyl/glutamyl-tRNA amidotransferase subunit B; Validated; Region: gatB; PRK05477
633149005011	GatB/GatE catalytic domain; Region: GatB_N; pfam02934
633149005012	GatB domain; Region: GatB_Yqey; smart00845
633149005013	exodeoxyribonuclease VII large subunit; Reviewed; Region: xseA; PRK00286
633149005014	ExoVII_LU_OBF: A subfamily of OB folds corresponding to the N-terminal OB-fold domain of Escherichia coli exodeoxyribonuclease VII (ExoVII) large subunit. E. coli ExoVII is composed of two non-identical subunits. E. coli ExoVII is a...; Region: ExoVII_LU_OBF; cd04489
633149005015	generic binding surface II; other site
633149005016	generic binding surface I; other site
633149005017	phosphoribosylamine--glycine ligase; Provisional; Region: PRK00885
633149005018	Phosphoribosylglycinamide synthetase, N domain; Region: GARS_N; pfam02844
633149005019	Phosphoribosylglycinamide synthetase, ATP-grasp (A) domain; Region: GARS_A; pfam01071
633149005020	Phosphoribosylglycinamide synthetase, C domain; Region: GARS_C; pfam02843
633149005021	L,D-transpeptidase catalytic domain; Region: YkuD_2; pfam13645
633149005022	Imidazolonepropionase and related amidohydrolases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: HutI; COG1228
633149005023	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
633149005024	Metallo-dependent hydrolases, subgroup A is part of the superfamily of metallo-dependent hydrolases, a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the...; Region: Met_dep_hydrolase_A; cd01299
633149005025	active site
633149005026	Tetraacyldisaccharide-1-P 4'-kinase [Cell envelope biogenesis, outer membrane]; Region: LpxK; COG1663
633149005027	Tetraacyldisaccharide-1-P 4'-kinase; Region: LpxK; pfam02606
633149005028	3-deoxy-D-manno-octulosonic-acid transferase; Reviewed; Region: PRK05749
633149005029	3-Deoxy-D-manno-octulosonic-acid transferase (kdotransferase); Region: Glycos_transf_N; pfam04413
633149005030	Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: DUF374; Region: LPLAT_DUF374-like; cd07983
633149005031	putative acyl-acceptor binding pocket; other site
633149005032	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
633149005033	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
633149005034	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
633149005035	Walker A/P-loop; other site
633149005036	ATP binding site [chemical binding]; other site
633149005037	Q-loop/lid; other site
633149005038	ABC transporter signature motif; other site
633149005039	Walker B; other site
633149005040	D-loop; other site
633149005041	H-loop/switch region; other site
633149005042	Protein tyrosine/serine phosphatase [Signal transduction mechanisms]; Region: COG2365
633149005043	Putative phosphatase (DUF442); Region: DUF442; cl17385
633149005044	Domain of unknown function (DUF4170); Region: DUF4170; pfam13773
633149005045	CysQ, a 3'-Phosphoadenosine-5'-phosphosulfate (PAPS) 3'-phosphatase, is a bacterial member of the inositol monophosphatase family. It has been proposed that CysQ helps control intracellular levels of PAPS, which is an intermediate in...; Region: CysQ; cd01638
633149005046	Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483
633149005047	active site
633149005048	peptidase PmbA; Provisional; Region: PRK11040
633149005049	MAPEG family; Region: MAPEG; cl09190
633149005050	Peptidase M14-like domain; uncharacterized subgroup; Region: M14-like_1_4; cd06241
633149005051	putative active site [active]
633149005052	Zn binding site [ion binding]; other site
633149005053	3-octaprenyl-4-hydroxybenzoate carboxy-lyase; Region: UbiD; cl00311
633149005054	DNA topoisomerase IV subunit B; Reviewed; Region: PRK05559
633149005055	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
633149005056	Mg2+ binding site [ion binding]; other site
633149005057	G-X-G motif; other site
633149005058	TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822
633149005059	anchoring element; other site
633149005060	dimer interface [polypeptide binding]; other site
633149005061	ATP binding site [chemical binding]; other site
633149005062	Topoisomerase-primase domain. This is a nucleotidyl transferase/hydrolase domain found in type IA, type IIA and type IIB topoisomerases, bacterial DnaG-type primases, small primase-like proteins from bacteria and archaea, OLD family nucleases from...; Region: TOPRIM; cl00718
633149005063	active site
633149005064	metal binding site [ion binding]; metal-binding site
633149005065	DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986
633149005066	O-Antigen ligase; Region: Wzy_C; pfam04932
633149005067	Lipid A core - O-antigen ligase and related enzymes [Cell envelope biogenesis, outer membrane]; Region: RfaL; COG3307
633149005068	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl17200
633149005069	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
633149005070	Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248
633149005071	active site
633149005072	catalytic tetrad [active]
633149005073	Predicted alpha/beta hydrolase [General function prediction only]; Region: COG4757
633149005074	Protein of unknown function (DUF419); Region: DUF419; cl15265
633149005075	Flavin reductase like domain; Region: Flavin_Reduct; smart00903
633149005076	3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084
633149005077	6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599
633149005078	cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the...; Region: cyclophilin; cd00317
633149005079	active site
633149005080	Porphobilinogen synthase (PBGS), which is also called delta-aminolevulinic acid dehydratase (ALAD), catalyzes the condensation of two 5-aminolevulinic acid (ALA) molecules to form the pyrrole porphobilinogen (PBG), which is the second step in the...; Region: ALAD_PBGS_aspartate_rich; cd04823
633149005081	dimer interface [polypeptide binding]; other site
633149005082	active site
633149005083	aspartate-rich active site metal binding site; other site
633149005084	allosteric magnesium binding site [ion binding]; other site
633149005085	Schiff base residues; other site
633149005086	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
633149005087	Isobutyryl-CoA dehydrogenase; Region: IBD; cd01162
633149005088	substrate binding pocket [chemical binding]; other site
633149005089	FAD binding site [chemical binding]; other site
633149005090	catalytic base [active]
633149005091	3-hydroxyisobutyryl-CoA hydrolase; Provisional; Region: PRK05617
633149005092	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
633149005093	substrate binding site [chemical binding]; other site
633149005094	oxyanion hole (OAH) forming residues; other site
633149005095	trimer interface [polypeptide binding]; other site
633149005096	2-enoyl-CoA Hydratase C-terminal region; Region: ECH_C; pfam13766
633149005097	Predicted methyltransferase [General function prediction only]; Region: COG4798
633149005098	EthD domain; Region: EthD; cl17553
633149005099	6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599
633149005100	Plant protein of unknown function (DUF825); Region: DUF825; pfam05695
633149005101	KBL_like; this family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to serine palmitoyltransferase (SPT), 5-aminolevulinate synthase (ALAS); Region: KBL_like; cd06454
633149005102	Aminotransferase class I and II; Region: Aminotran_1_2; pfam00155
633149005103	substrate-cofactor binding pocket; other site
633149005104	pyridoxal 5'-phosphate binding site [chemical binding]; other site
633149005105	catalytic residue [active]
633149005106	serine hydroxymethyltransferase; Reviewed; Region: glyA; PRK00011
633149005107	Serine-glycine hydroxymethyltransferase (SHMT). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). SHMT carries out interconversion of serine and glycine; it catalyzes the transfer of hydroxymethyl...; Region: SHMT; cd00378
633149005108	dimer interface [polypeptide binding]; other site
633149005109	active site
633149005110	glycine-pyridoxal phosphate binding site [chemical binding]; other site
633149005111	folate binding site [chemical binding]; other site
633149005112	transcriptional regulator NrdR; Validated; Region: nrdR; PRK00464
633149005113	ATP cone domain; Region: ATP-cone; pfam03477
633149005114	Pyrimidine reductase, riboflavin biosynthesis [Coenzyme metabolism]; Region: RibD; COG1985
633149005115	RibD C-terminal domain; Region: RibD_C; cl17279
633149005116	riboflavin synthase subunit alpha; Provisional; Region: PRK09289
633149005117	Lumazine binding domain; Region: Lum_binding; pfam00677
633149005118	Lumazine binding domain; Region: Lum_binding; pfam00677
633149005119	bifunctional 3,4-dihydroxy-2-butanone 4-phosphate synthase/GTP cyclohydrolase II-like protein; Provisional; Region: PRK14019
633149005120	3,4-dihydroxy-2-butanone 4-phosphate synthase; Region: DHBP_synthase; pfam00926
633149005121	GTP cyclohydrolase II; Region: GTP_cyclohydro2; pfam00925
633149005122	dimerization interface [polypeptide binding]; other site
633149005123	active site
633149005124	lumazine synthase (6,7-dimethyl-8-ribityllumazine synthase, LS), catalyzes the penultimate step in the biosynthesis of riboflavin (vitamin B2); type-I; Region: Lumazine_synthase-I; cd09209
633149005125	homopentamer interface [polypeptide binding]; other site
633149005126	active site
633149005127	transcription antitermination protein NusB; Reviewed; Region: nusB; PRK00202
633149005128	thiamine-monophosphate kinase; Region: thiL; TIGR01379
633149005129	ThiL (Thiamine-monophosphate kinase) plays a dual role in de novo biosynthesis and in salvage of exogenous thiamine. Thiamine salvage occurs in two steps, with thiamine kinase catalyzing the formation of thiamine phosphate, and ThiL catalyzing the...; Region: ThiL; cd02194
633149005130	ATP binding site [chemical binding]; other site
633149005131	dimerization interface [polypeptide binding]; other site
633149005132	Inorganic pyrophosphatase [Energy production and conversion]; Region: OVP1; COG3808
633149005133	H(+) -translocating inorganic pyrophosphatase; Region: PLN02255; cl11452
633149005134	Outer membrane lipoprotein OmlA (small protein A) [Cell envelope biogenesis, outer membrane]; Region: OlmA; COG2913
633149005135	SmpA / OmlA family; Region: SmpA_OmlA; pfam04355
633149005136	Ubiquinol-cytochrome C chaperone; Region: Ubiq_cyt_C_chap; cl12045
633149005137	Uncharacterized ACR, COG1399; Region: DUF177; pfam02620
633149005138	putative phosphate acyltransferase; Provisional; Region: PRK05331
633149005139	3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK09352
633149005140	Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830
633149005141	dimer interface [polypeptide binding]; other site
633149005142	active site
633149005143	CoA binding pocket [chemical binding]; other site
633149005144	Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591
633149005145	IHF dimer interface [polypeptide binding]; other site
633149005146	IHF - DNA interface [nucleotide binding]; other site
633149005147	Helix-Turn-Helix DNA binding domain of putative MlrA-like transcription regulators; Region: HTH_MlrA-like_sg2; cd04765
633149005148	MerR HTH family regulatory protein; Region: MerR_1; pfam13411
633149005149	DNA binding residues [nucleotide binding]
633149005150	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
633149005151	PAS domain; Region: PAS_9; pfam13426
633149005152	putative active site [active]
633149005153	heme pocket [chemical binding]; other site
633149005154	Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283
633149005155	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
633149005156	dimer interface [polypeptide binding]; other site
633149005157	putative CheW interface [polypeptide binding]; other site
633149005158	Protein of unknown function (DUF2842); Region: DUF2842; pfam11003
633149005159	Cytochrome oxidase assembly protein; Region: COX15-CtaA; cl15852
633149005160	Uncharacterized protein required for cytochrome oxidase assembly [Posttranslational modification, protein turnover, chaperones]; Region: CtaA; COG1612
633149005161	Ribosomal protein L13.  Protein L13, a large ribosomal subunit protein, is one of five proteins required for an early folding intermediate of 23S rRNA in the assembly of the large subunit. L13 is situated on the bottom of the large subunit, near the...; Region: Ribosomal_L13; cd00392
633149005162	23S rRNA interface [nucleotide binding]; other site
633149005163	L3 interface [polypeptide binding]; other site
633149005164	30S ribosomal protein S9; Reviewed; Region: rpsI; PRK00132
633149005165	N-acetyl-gamma-glutamyl-phosphate reductase; Provisional; Region: PRK11863
633149005166	Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859
633149005167	Conserved domain frequently associated with peptide methionine sulfoxide reductase [Posttranslational modification, protein turnover, chaperones]; Region: COG0229; cl15841
633149005168	SelR domain; Region: SelR; pfam01641
633149005169	poly(R)-hydroxyalkanoic acid synthase, class I; Region: PHA_synth_I; TIGR01838
633149005170	Poly-beta-hydroxybutyrate polymerase (PhaC) N-terminus; Region: PhaC_N; pfam07167
633149005171	Bacterial fructose-1,6-bisphosphatase, glpX-encoded. A dimeric enzyme dependent on Mg(2+). glpX-encoded FPBase (FBPase class II) differs from other members of the inositol-phosphatase superfamily by permutation of secondary structure elements. The core...; Region: FBPase_glpX; cd01516
633149005172	Bacterial fructose-1,6-bisphosphatase, glpX-encoded; Region: FBPase_glpX; pfam03320
633149005173	putative active site [active]
633149005174	single-stranded-DNA-specific exonuclease RecJ; Region: recJ; TIGR00644
633149005175	DHH family; Region: DHH; pfam01368
633149005176	Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea.  CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458
633149005177	DNA-binding site [nucleotide binding]; DNA binding site
633149005178	RNA-binding motif; other site
633149005179	Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea.  CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458
633149005180	DNA-binding site [nucleotide binding]; DNA binding site
633149005181	RNA-binding motif; other site
633149005182	Uncharacterized ACR, COG1430; Region: DUF192; pfam02643
633149005183	ETC complex I subunit conserved region; Region: ETC_C1_NDUFA4; pfam04800
633149005184	cystathionine beta-lyase, bacterial; Region: cysta_beta_ly_B; TIGR01324
633149005185	Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321
633149005186	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
633149005187	catalytic residue [active]
633149005188	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
633149005189	Bacterial periplasmic substrate-binding proteins; Region: PBPb; smart00062
633149005190	substrate binding pocket [chemical binding]; other site
633149005191	membrane-bound complex binding site; other site
633149005192	hinge residues; other site
633149005193	Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301
633149005194	Sodium:dicarboxylate symporter family; Region: SDF; pfam00375
633149005195	Rhodanese-related sulfurtransferase [Inorganic ion transport and metabolism]; Region: SseA; COG2897
633149005196	Thiosulfate sulfurtransferase (TST), N-terminal, inactive domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the 1st repeat, which does not contain the catalytically active Cys residue. The role of the 1st repeat is uncertain, but it...; Region: TST_Repeat_1; cd01448
633149005197	active site residue [active]
633149005198	Thiosulfate sulfurtransferase (TST), C-terminal, catalytic domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the second repeat. Only the second repeat contains the catalytically active Cys residue; Region: TST_Repeat_2; cd01449
633149005199	active site residue [active]
633149005200	Uncharacterized protein related to deoxyribodipyrimidine photolyase [General function prediction only]; Region: COG3046
633149005201	Deoxyribodipyrimidine photo-lyase-related protein; Region: DPRP; pfam04244
633149005202	Cyclopropane fatty acid synthase and related methyltransferases [Cell envelope biogenesis, outer membrane]; Region: Cfa; COG2230
633149005203	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
633149005204	S-adenosylmethionine binding site [chemical binding]; other site
633149005205	Deoxyribodipyrimidine photolyase [DNA replication, recombination, and repair]; Region: PhrB; COG0415
633149005206	DNA photolyase; Region: DNA_photolyase; pfam00875
633149005207	2-dehydro-3-deoxyphosphooctonate aldolase; Provisional; Region: PRK05198
633149005208	ADP-heptose synthase, bifunctional sugar kinase/adenylyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaE; COG2870
633149005209	ribokinase/pfkB superfamily: Kinases that accept a wide variety of substrates, including carbohydrates and aromatic small molecules, all are phosphorylated at a hydroxyl group. The superfamily includes ribokinase, fructokinase, ketohexokinase; Region: ribokinase_pfkB_like; cl00192
633149005210	substrate binding site [chemical binding]; other site
633149005211	ATP binding site [chemical binding]; other site
633149005212	rfaE bifunctional protein, domain II; Region: rfaE_dom_II; TIGR02199
633149005213	active site
633149005214	HIGH motif; other site
633149005215	nucleotide binding site [chemical binding]; other site
633149005216	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
633149005217	ADP-L-glycero-D-manno-heptose-6-epimerase; Region: heptose_epim; TIGR02197
633149005218	NAD(P) binding site [chemical binding]; other site
633149005219	active site
633149005220	Protein of unknown function (DUF3089); Region: DUF3089; pfam11288
633149005221	ATP-dependent DNA helicase RecG; Provisional; Region: PRK10917
633149005222	RecG_wedge_OBF: A subfamily of OB folds corresponding to the OB fold found in the N-terminal (wedge) domain of Escherichia coli RecG. RecG is a branched-DNA-specific helicase, which catalyzes the interconversion of a DNA replication fork to a...; Region: RecG_wedge_OBF; cd04488
633149005223	ssDNA binding site; other site
633149005224	generic binding surface II; other site
633149005225	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
633149005226	ATP binding site [chemical binding]; other site
633149005227	putative Mg++ binding site [ion binding]; other site
633149005228	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
633149005229	nucleotide binding region [chemical binding]; other site
633149005230	ATP-binding site [chemical binding]; other site
633149005231	Flavinator of succinate dehydrogenase; Region: Sdh5; cl01110
633149005232	Transcription-repair coupling factor (superfamily II helicase) [DNA replication, recombination, and repair / Transcription]; Region: Mfd; COG1197
633149005233	CarD-like/TRCF domain; Region: CarD_TRCF; smart01058
633149005234	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
633149005235	ATP binding site [chemical binding]; other site
633149005236	putative Mg++ binding site [ion binding]; other site
633149005237	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
633149005238	nucleotide binding region [chemical binding]; other site
633149005239	ATP-binding site [chemical binding]; other site
633149005240	This domain is found in proteins necessary for strand-specific repair in DNA such as TRCF in Escherichia coli; Region: TRCF; smart00982
633149005241	Coenzyme F420 hydrogenase/dehydrogenase, beta subunit N-term; Region: FrhB_FdhB_N; pfam04422
633149005242	Coenzyme F420 hydrogenase/dehydrogenase, beta subunit C terminus; Region: FrhB_FdhB_C; pfam04432
633149005243	Putative p-aminobenzoyl-glutamate transporter [Coenzyme metabolism]; Region: AbgT; COG2978
633149005244	p-Aminobenzoyl-glutamate transporter family; Region: ydaH; TIGR00819
633149005245	NADH:ubiquinone oxidoreductase subunit A; Validated; Region: PRK06602
633149005246	NADH dehydrogenase subunit B; Validated; Region: PRK06411
633149005247	NADH dehydrogenase subunit C; Provisional; Region: PRK06074
633149005248	NADH (or F420H2) dehydrogenase, subunit C; Region: NuoC_fam; TIGR01961
633149005249	NADH:ubiquinone oxidoreductase 49 kD subunit 7 [Energy production and conversion]; Region: NuoD; COG0649
633149005250	NADH dehydrogenase subunit D; Validated; Region: PRK06075
633149005251	NADH dehydrogenase subunit E; Validated; Region: PRK07539
633149005252	TRX-like [2Fe-2S] Ferredoxin (Fd) family, NADH:ubiquinone oxidoreductase (Nuo) subunit E subfamily; Nuo, also called respiratory chain Complex 1, is the entry point for electrons into the respiratory chains of bacteria and the mitochondria of eukaryotes; Region: TRX_Fd_NuoE; cd03064
633149005253	putative dimer interface [polypeptide binding]; other site
633149005254	[2Fe-2S] cluster binding site [ion binding]; other site
633149005255	NADH dehydrogenase I subunit F; Provisional; Region: PRK13596
633149005256	SLBB domain; Region: SLBB; pfam10531
633149005257	NADH-ubiquinone oxidoreductase-F iron-sulfur binding region; Region: NADH_4Fe-4S; smart00928
633149005258	NADH dehydrogenase subunit G; Validated; Region: PRK09130
633149005259	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
633149005260	catalytic loop [active]
633149005261	iron binding site [ion binding]; other site
633149005262	NADH-ubiquinone oxidoreductase-G iron-sulfur binding region; Region: NADH-G_4Fe-4S_3; pfam10588
633149005263	MopB_Res_Cmplx1_Nad11: The second domain of the Nad11/75-kDa subunit of the NADH-quinone oxidoreductase/respiratory complex I/NADH dehydrogenase-1(NDH-1) of eukaryotes and the Nqo3/G subunit of alphaproteobacteria NDH-1. The NADH-quinone oxidoreductase...; Region: MopB_Res-Cmplx1_Nad11; cd02773
633149005264	Domain of unknown function (DUF1982); Region: DUF1982; pfam09326
633149005265	NADH:ubiquinone oxidoreductase subunit H; Provisional; Region: PRK06076
633149005266	Formate hydrogenlyase subunit 4 [Energy production and conversion]; Region: HyfC; COG0650
633149005267	NADH dehydrogenase subunit I; Provisional; Region: PRK05888
633149005268	4Fe-4S binding domain; Region: Fer4; pfam00037
633149005269	4Fe-4S binding domain; Region: Fer4; pfam00037
633149005270	NADH:ubiquinone oxidoreductase subunit J; Provisional; Region: PRK06638
633149005271	NADH dehydrogenase subunit 6; Provisional; Region: ND6; MTH00213
633149005272	NADH dehydrogenase subunit 6; Provisional; Region: ND6; MTH00213
633149005273	NADH:ubiquinone oxidoreductase subunit K; Validated; Region: PRK05715
633149005274	NADH:ubiquinone oxidoreductase subunit L; Reviewed; Region: PRK06590
633149005275	NADH-Ubiquinone oxidoreductase (complex I), chain 5 N-terminus; Region: Oxidored_q1_N; pfam00662
633149005276	NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361
633149005277	NADH:ubiquinone oxidoreductase subunit M; Reviewed; Region: PRK05846
633149005278	NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361
633149005279	NADH:ubiquinone oxidoreductase subunit N; Provisional; Region: PRK05777
633149005280	NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361
633149005281	Biotin-(acetyl-CoA carboxylase) ligase [Coenzyme metabolism]; Region: BirA; COG0340
633149005282	Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; cl14057
633149005283	Biotin protein ligase C terminal domain; Region: BPL_C; pfam02237
633149005284	pantothenate kinase; Reviewed; Region: PRK13318
633149005285	mRNA degradation ribonucleases J1/J2 (metallo-beta-lactamase superfamily) [Translation, ribosomal structure and biogenesis; Replication, recombination and repair]; Region: COG0595
633149005286	Metallo-beta-lactamase superfamily; Region: Lactamase_B; pfam00753
633149005287	RNA-metabolising metallo-beta-lactamase; Region: RMMBL; pfam07521
633149005288	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
633149005289	Methylmalonyl-CoA epimerase (MMCE); Region: MMCE; cd07249
633149005290	dimer interface [polypeptide binding]; other site
633149005291	substrate binding site [chemical binding]; other site
633149005292	metal binding site [ion binding]; metal-binding site
633149005293	Protein of unknown function (DUF1467); Region: DUF1467; pfam07330
633149005294	Uncharacterized protein conserved in bacteria (DUF2141); Region: DUF2141; pfam09912
633149005295	prolyl-tRNA synthetase; Provisional; Region: PRK12325
633149005296	Prolyl-tRNA synthetase (ProRS) class II core catalytic domain. ProRS is a homodimer. It is responsible for the attachment of proline to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ProRS_core_prok; cd00779
633149005297	dimer interface [polypeptide binding]; other site
633149005298	motif 1; other site
633149005299	active site
633149005300	motif 2; other site
633149005301	motif 3; other site
633149005302	ProRS Prolyl-anticodon binding domain, short version found predominantly in bacteria. ProRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding; Region: ProRS_anticodon_short; cd00861
633149005303	anticodon binding site; other site
633149005304	lipoprotein releasing system, transmembrane protein, LolC/E family; Region: lolCE; TIGR02212
633149005305	MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
633149005306	FtsX-like permease family; Region: FtsX; pfam02687
633149005307	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
633149005308	ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255
633149005309	Walker A/P-loop; other site
633149005310	ATP binding site [chemical binding]; other site
633149005311	Q-loop/lid; other site
633149005312	ABC transporter signature motif; other site
633149005313	Walker B; other site
633149005314	D-loop; other site
633149005315	H-loop/switch region; other site
633149005316	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
633149005317	active site
633149005318	Pyridoxine 5'-phosphate (PNP) synthase domain; pyridoxal 5'-phosphate is the active form of vitamin B6 that acts as an essential, ubiquitous coenzyme in amino acid metabolism. In bacteria, formation of pyridoxine 5'-phosphate is a step in...; Region: PNPsynthase; cd00003
633149005319	active site
633149005320	hydrophilic channel; other site
633149005321	dimerization interface [polypeptide binding]; other site
633149005322	catalytic residues [active]
633149005323	active site lid [active]
633149005324	4'-phosphopantetheinyl transferase; Provisional; Region: acpS; PRK00070
633149005325	signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227
633149005326	The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530
633149005327	Catalytic site [active]
633149005328	The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530
633149005329	ribonuclease III, bacterial; Region: RNaseIII; TIGR02191
633149005330	RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in...; Region: RIBOc; cd00593
633149005331	dimerization interface [polypeptide binding]; other site
633149005332	active site
633149005333	metal binding site [ion binding]; metal-binding site
633149005334	Double-stranded RNA binding motif. Binding is not sequence specific but is highly specific for double stranded RNA. Found in a variety of proteins including dsRNA dependent protein kinase PKR, RNA helicases, Drosophila staufen protein, E. coli RNase III; Region: DSRM; cd00048
633149005335	dsRNA binding site [nucleotide binding]; other site
633149005336	GTPase Era; Reviewed; Region: era; PRK00089
633149005337	E. coli Ras-like protein (Era) is a multifunctional GTPase; Region: Era; cd04163
633149005338	G1 box; other site
633149005339	GTP/Mg2+ binding site [chemical binding]; other site
633149005340	Switch I region; other site
633149005341	G2 box; other site
633149005342	Switch II region; other site
633149005343	G3 box; other site
633149005344	G4 box; other site
633149005345	G5 box; other site
633149005346	KH domain; Region: KH_2; pfam07650
633149005347	Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680
633149005348	Beta-lactamase; Region: Beta-lactamase; pfam00144
633149005349	Escherichia coli PhnB and similar proteins; the E. coli phnB gene is found next to an operon involved in the cleavage of carbon-phosphorus bonds in unactivated alkylphosphonates; Region: PhnB_like; cd06588
633149005350	dimer interface [polypeptide binding]; other site
633149005351	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
633149005352	Putative hydrophobic ligand-binding SRPBCC domain of Micromonospora echinospora CalC, human Aha1, and related proteins; Region: SRPBCC_CalC_Aha1-like; cd07814
633149005353	putative hydrophobic ligand binding site [chemical binding]; other site
633149005354	Putative hydrophobic ligand-binding SRPBCC domain of an uncharacterized subgroup of CalC- and Aha1-like proteins; Region: SRPBCC_CalC_Aha1-like_3; cd08896
633149005355	putative hydrophobic ligand binding site [chemical binding]; other site
633149005356	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
633149005357	dimerization interface [polypeptide binding]; other site
633149005358	putative DNA binding site [nucleotide binding]; other site
633149005359	putative Zn2+ binding site [ion binding]; other site
633149005360	Multimeric flavodoxin WrbA [General function prediction only]; Region: WrbA; COG0655
633149005361	NADPH-dependent FMN reductase; Region: FMN_red; pfam03358
633149005362	Calcium/calmodulin dependent protein kinase II Association; Region: CaMKII_AD; cl17504
633149005363	SnoaL-like domain; Region: SnoaL_3; pfam13474
633149005364	DNA repair protein RecO; Reviewed; Region: recO; PRK00085
633149005365	Recombination protein O N terminal; Region: RecO_N; pfam11967
633149005366	Recombination protein O C terminal; Region: RecO_C; pfam02565
633149005367	phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966
633149005368	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
633149005369	putative active site [active]
633149005370	heme pocket [chemical binding]; other site
633149005371	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
633149005372	dimer interface [polypeptide binding]; other site
633149005373	phosphorylation site [posttranslational modification]
633149005374	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
633149005375	ATP binding site [chemical binding]; other site
633149005376	Mg2+ binding site [ion binding]; other site
633149005377	G-X-G motif; other site
633149005378	Response regulator receiver domain; Region: Response_reg; pfam00072
633149005379	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
633149005380	active site
633149005381	phosphorylation site [posttranslational modification]
633149005382	intermolecular recognition site; other site
633149005383	dimerization interface [polypeptide binding]; other site
633149005384	DNA topoisomerase IV subunit A; Validated; Region: PRK05561
633149005385	DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187
633149005386	CAP-like domain; other site
633149005387	active site
633149005388	primary dimer interface [polypeptide binding]; other site
633149005389	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
633149005390	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
633149005391	Uncharacterized conserved protein [Function unknown]; Region: LemA; COG1704
633149005392	Peptidase family M48; Region: Peptidase_M48; cl12018
633149005393	pyruvate dehydrogenase E1 component, alpha subunit; Region: PDH_E1_alph_y; TIGR03182
633149005394	Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000
633149005395	tetramer interface [polypeptide binding]; other site
633149005396	TPP-binding site [chemical binding]; other site
633149005397	heterodimer interface [polypeptide binding]; other site
633149005398	phosphorylation loop region [posttranslational modification]
633149005399	pyruvate dehydrogenase subunit beta; Provisional; Region: PRK11892
633149005400	Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849
633149005401	E3 interaction surface; other site
633149005402	lipoyl attachment site [posttranslational modification]; other site
633149005403	Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036
633149005404	alpha subunit interface [polypeptide binding]; other site
633149005405	TPP binding site [chemical binding]; other site
633149005406	heterodimer interface [polypeptide binding]; other site
633149005407	Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780
633149005408	branched-chain alpha-keto acid dehydrogenase subunit E2; Reviewed; Region: PRK11856
633149005409	Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849
633149005410	E3 interaction surface; other site
633149005411	lipoyl attachment site [posttranslational modification]; other site
633149005412	e3 binding domain; Region: E3_binding; pfam02817
633149005413	2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198
633149005414	Glutathione (GSH) peroxidase family; tetrameric selenoenzymes that catalyze the reduction of a variety of hydroperoxides including lipid peroxidases, using GSH as a specific electron donor substrate. GSH peroxidase contains one selenocysteine residue per...; Region: GSH_Peroxidase; cd00340
633149005415	catalytic residues [active]
633149005416	dimer interface [polypeptide binding]; other site
633149005417	Protein of unknown function (DUF3667); Region: DUF3667; pfam12412
633149005418	putative FAD-binding dehydrogenase; Reviewed; Region: PRK12834
633149005419	dihydrolipoamide dehydrogenase; Reviewed; Region: PRK06416
633149005420	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
633149005421	Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852
633149005422	Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670
633149005423	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
633149005424	Coenzyme A binding pocket [chemical binding]; other site
633149005425	Protein of unknown function (DUF3606); Region: DUF3606; pfam12244
633149005426	Metal-dependent hydrolases of the beta-lactamase superfamily I [General function prediction only]; Region: PhnP; COG1235
633149005427	putative hydrolase; Provisional; Region: PRK02113
633149005428	TatD like proteins;  E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310
633149005429	active site
633149005430	DNA polymerase III, delta' subunit; Region: holB; TIGR00678
633149005431	DNA polymerase III subunit delta'; Validated; Region: PRK08485
633149005432	ATPase involved in DNA replication [DNA replication, recombination, and repair]; Region: HolB; COG0470
633149005433	thymidylate kinase; Validated; Region: tmk; PRK00698
633149005434	Thymidine monophosphate kinase (TMPK), also known as thymidylate kinase, catalyzes the phosphorylation of thymidine monophosphate (TMP) to thymidine diphosphate (TDP) utilizing ATP as its preferred phophoryl donor. TMPK represents the rate-limiting step...; Region: TMPK; cd01672
633149005435	TMP-binding site; other site
633149005436	ATP-binding site [chemical binding]; other site
633149005437	Lipoproteins [Cell envelope biogenesis, outer membrane]; Region: RlpA; COG0797
633149005438	Rare lipoprotein A (RlpA)-like double-psi beta-barrel; Region: DPBB_1; pfam03330
633149005439	Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961
633149005440	Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and...; Region: SR_ResInv; cd03768
633149005441	catalytic residues [active]
633149005442	catalytic nucleophile [active]
633149005443	Presynaptic Site I dimer interface [polypeptide binding]; other site
633149005444	Synaptic Antiparallel dimer interface [polypeptide binding]; other site
633149005445	Synaptic Flat tetramer interface [polypeptide binding]; other site
633149005446	Synaptic Site I dimer interface [polypeptide binding]; other site
633149005447	DNA binding site [nucleotide binding]
633149005448	Recombinase; Region: Recombinase; pfam07508
633149005449	Protein of unknown function (DUF2924); Region: DUF2924; pfam11149
633149005450	Protein of unknown function (DUF3489); Region: DUF3489; pfam11994
633149005451	Stage 0 sporulation protein J (antagonist of Soj) containing ParB-like nuclease domain [Transcription]; Region: Spo0J; COG1475
633149005452	ParB-like nuclease domain; Region: ParB; smart00470
633149005453	DNA modification methylase [DNA replication, recombination, and repair]; Region: COG0863
633149005454	DNA methylase; Region: N6_N4_Mtase; pfam01555
633149005455	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5410
633149005456	Phage-related terminase [General function prediction only]; Region: COG5362; cl02216
633149005457	Domain of unknown function (DUF4062); Region: DUF4062; pfam13271
633149005458	AAA domain; Region: AAA_22; pfam13401
633149005459	SIR2 superfamily of proteins includes silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein/histone deacetylation, where the acetyl group from the lysine epsilon-amino group is transferred to the ADP-ribose moiety of NAD+; Region: SIR2; cl00195
633149005460	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
633149005461	Transcriptional activator of acetoin/glycerol metabolism [Secondary metabolites biosynthesis, transport, and catabolism / Transcription]; Region: AcoR; COG3284
633149005462	Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954
633149005463	Ralstonia eutrophus NAD+-dependent acetaldehyde dehydrogenase II-like; Region: ALDH_ACDHII-AcoD; cd07116
633149005464	Aldehyde dehydrogenase family; Region: Aldedh; pfam00171
633149005465	NAD(P) binding site [chemical binding]; other site
633149005466	catalytic residues [active]
633149005467	Uncharacterized protein conserved in bacteria (DUF2171); Region: DUF2171; pfam09939
633149005468	Helix-hairpin-helix motif; Region: HHH_3; pfam12836
633149005469	Protein of unknown function (DUF2924); Region: DUF2924; pfam11149
633149005470	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
633149005471	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
633149005472	non-specific DNA binding site [nucleotide binding]; other site
633149005473	salt bridge; other site
633149005474	sequence-specific DNA binding site [nucleotide binding]; other site
633149005475	Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471
633149005476	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
633149005477	active site
633149005478	DNA binding site [nucleotide binding]
633149005479	Int/Topo IB signature motif; other site
633149005480	Methylmalonate semialdehyde dehydrogenase and ALDH family members 6A1 and 6B2; Region: ALDH_F6_MMSDH; cd07085
633149005481	methylmalonic acid semialdehyde dehydrogenase; Region: MMSDH; TIGR01722
633149005482	tetrameric interface [polypeptide binding]; other site
633149005483	NAD binding site [chemical binding]; other site
633149005484	catalytic residues [active]
633149005485	Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072
633149005486	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738
633149005487	Esterases and lipases (includes fungal lipases, cholinesterases, etc.)  These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312
633149005488	alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859
633149005489	enoyl-CoA hydratase; Provisional; Region: PRK08140
633149005490	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
633149005491	substrate binding site [chemical binding]; other site
633149005492	oxyanion hole (OAH) forming residues; other site
633149005493	trimer interface [polypeptide binding]; other site
633149005494	lipid-transfer protein; Provisional; Region: PRK06059
633149005495	Thiolase domain associated with sterol carrier protein (SCP)-x isoform and related proteins; SCP-2  has multiple roles in intracellular lipid circulation and metabolism. The N-terminal presequence in the SCP-x isoform represents a peroxisomal...; Region: SCP-x_thiolase; cd00829
633149005496	active site
633149005497	DUF35 OB-fold domain; Region: DUF35; pfam01796
633149005498	(R)-hydratase [(R)-specific enoyl-CoA hydratase]. Catalyzes the hydration of trans-2-enoyl CoA to (R)-3-hydroxyacyl-CoA as part of the PHA (polyhydroxyalkanoate) biosynthetic pathway.  The structure of the monomer includes a five-strand antiparallel...; Region: R_hydratase_like; cd03441
633149005499	active site
633149005500	catalytic site [active]
633149005501	(R)-hydratase [(R)-specific enoyl-CoA hydratase]. Catalyzes the hydration of trans-2-enoyl CoA to (R)-3-hydroxyacyl-CoA as part of the PHA (polyhydroxyalkanoate) biosynthetic pathway.  The structure of the monomer includes a five-strand antiparallel...; Region: R_hydratase_like; cd03441
633149005502	active site
633149005503	catalytic site [active]
633149005504	Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629
633149005505	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244
633149005506	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
633149005507	Major Facilitator Superfamily; Region: MFS_1; pfam07690
633149005508	putative substrate translocation pore; other site
633149005509	AMP-binding domain protein; Validated; Region: PRK08315
633149005510	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
633149005511	Uncharacterized subfamily of fatty acid CoA ligase (FACL); Region: FACL_like_2; cd05917
633149005512	acyl-activating enzyme (AAE) consensus motif; other site
633149005513	putative AMP binding site [chemical binding]; other site
633149005514	putative active site [active]
633149005515	putative CoA binding site [chemical binding]; other site
633149005516	3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653
633149005517	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
633149005518	NAD(P) binding site [chemical binding]; other site
633149005519	active site
633149005520	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
633149005521	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
633149005522	Catalytic GIY-YIG domain of type II restriction endonucleases R.Eco29kI, R.Cfr42I, and similar proteins; Region: GIY-YIG_RE_Eco29kI_like; cd10435
633149005523	GIY-YIG motif/motif A; other site
633149005524	active site
633149005525	DNA binding site [nucleotide binding]
633149005526	homodimer interface [polypeptide binding]; other site
633149005527	putative metal binding site [ion binding]; other site
633149005528	Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group...; Region: Cyt_C5_DNA_methylase; cd00315
633149005529	C-5 cytosine-specific DNA methylase; Region: DNA_methylase; pfam00145
633149005530	cofactor binding site; other site
633149005531	DNA binding site [nucleotide binding]
633149005532	substrate interaction site [chemical binding]; other site
633149005533	Very Short Patch Repair (Vsr) Endonuclease. Endonucleases in DNA repair that recognize damaged DNA and cleave the phosphodiester backbone. Vsr endonucleases have a common endonuclease topology that has been tailored for recognition of TG mismatches; Region: Vsr; cd00221
633149005534	additional DNA contacts [nucleotide binding]; other site
633149005535	mismatch recognition site; other site
633149005536	active site
633149005537	zinc binding site [ion binding]; other site
633149005538	DNA intercalation site [nucleotide binding]; other site
633149005539	DEAD/DEAH box helicase; Region: DEAD; pfam00270
633149005540	Protein of unknown function DUF262; Region: DUF262; pfam03235
633149005541	Uncharacterized conserved protein [Function unknown]; Region: COG1479
633149005542	Protein of unknown function (DUF1524); Region: DUF1524; pfam07510
633149005543	feruloyl-CoA synthase; Reviewed; Region: PRK08180
633149005544	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
633149005545	acyl-activating enzyme (AAE) consensus motif; other site
633149005546	AMP binding site [chemical binding]; other site
633149005547	active site
633149005548	CoA binding site [chemical binding]; other site
633149005549	Rubredoxin-like zinc ribbon domain (DUF35_N); Region: DUF35_N; pfam12172
633149005550	DUF35 OB-fold domain; Region: DUF35; pfam01796
633149005551	acetyl-CoA acetyltransferase; Provisional; Region: PRK08142
633149005552	Thiolase domain associated with sterol carrier protein (SCP)-x isoform and related proteins; SCP-2  has multiple roles in intracellular lipid circulation and metabolism. The N-terminal presequence in the SCP-x isoform represents a peroxisomal...; Region: SCP-x_thiolase; cd00829
633149005553	active site
633149005554	ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components [Inorganic ion transport and metabolism]; Region: TauA; COG0715
633149005555	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
633149005556	membrane-bound complex binding site; other site
633149005557	hinge residues; other site
633149005558	Amidohydrolase; Region: Amidohydro_2; pfam04909
633149005559	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
633149005560	Major Facilitator Superfamily; Region: MFS_1; pfam07690
633149005561	putative substrate translocation pore; other site
633149005562	Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629
633149005563	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
633149005564	N-terminal plug; other site
633149005565	ligand-binding site [chemical binding]; other site
633149005566	Prokaryotic protein of unknown function (DUF849); Region: DUF849; pfam05853
633149005567	succinic semialdehyde dehydrogenase; Region: PLN02278
633149005568	Mitochondrial succinate-semialdehyde dehydrogenase and ALDH family members 5A1 and 5F1-like; Region: ALDH_F5_SSADH_GabD; cd07103
633149005569	tetramerization interface [polypeptide binding]; other site
633149005570	NAD(P) binding site [chemical binding]; other site
633149005571	catalytic residues [active]
633149005572	SnoaL-like domain; Region: SnoaL_4; pfam13577
633149005573	DNA-binding transcriptional activator FeaR; Provisional; Region: PRK09685
633149005574	Cupin domain; Region: Cupin_2; cl17218
633149005575	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
633149005576	HpcH/HpaI aldolase/citrate lyase family; Region: HpcH_HpaI; cl17231
633149005577	Predicted metal-dependent hydrolase of the TIM-barrel fold [General function prediction only]; Region: COG3618
633149005578	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
633149005579	active site
633149005580	Protein of unknown function (DUF861); Region: Cupin_3; cl17594
633149005581	SnoaL-like domain; Region: SnoaL_4; pfam13577
633149005582	SnoaL-like domain; Region: SnoaL_4; pfam13577
633149005583	SnoaL-like domain; Region: SnoaL_4; pfam13577
633149005584	classical (c) SDRs; Region: SDR_c; cd05233
633149005585	NAD(P) binding site [chemical binding]; other site
633149005586	active site
633149005587	Iron-containing alcohol dehydrogenase; Region: Fe-ADH; pfam00465
633149005588	5-hydroxyvalerate dehydrogenase (HVD) catalyzes the oxidation of 5-hydroxyvalerate to 5-oxovalerate with NAD+ as cofactor; Region: HVD; cd08193
633149005589	putative active site [active]
633149005590	metal binding site [ion binding]; metal-binding site
633149005591	Anion permease ArsB/NhaD.  These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life.  A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cd00625
633149005592	transmembrane helices; other site
633149005593	Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; Region: CitT; COG0471
633149005594	putative monovalent cation/H+ antiporter subunit A; Reviewed; Region: PRK12648
633149005595	NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361
633149005596	Multisubunit Na+/H+ antiporter, MnhB subunit [Inorganic ion transport and metabolism]; Region: MnhB; COG2111
633149005597	putative monovalent cation/H+ antiporter subunit B; Reviewed; Region: PRK12573
633149005598	putative monovalent cation/H+ antiporter subunit C; Reviewed; Region: PRK09094
633149005599	putative monovalent cation/H+ antiporter subunit D; Reviewed; Region: PRK12666
633149005600	NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361
633149005601	putative monovalent cation/H+ antiporter subunit E; Reviewed; Region: PRK08965
633149005602	putative monovalent cation/H+ antiporter subunit F; Reviewed; Region: PRK06161
633149005603	putative monovalent cation/H+ antiporter subunit G; Reviewed; Region: PRK12674
633149005604	NhaP-type Na+/H+ and K+/H+ antiporters [Inorganic ion transport and metabolism]; Region: NhaP; COG0025
633149005605	Ubiquinol oxidase subunit I.  Ubiquinol oxidase, the terminal oxidase in the respiratory chains of aerobic bacteria, is a multi-chain transmembrane protein located in the cell membrane.  It catalyzes the reduction of O2 and simultaneously pumps protons...; Region: Ubiquinol_Oxidase_I; cd01662
633149005606	D-pathway; other site
633149005607	Putative ubiquinol binding site [chemical binding]; other site
633149005608	Cytochrome C and Quinol oxidase polypeptide I; Region: COX1; pfam00115
633149005609	Low-spin heme (heme b) binding site [chemical binding]; other site
633149005610	Putative water exit pathway; other site
633149005611	Binuclear center (heme o3/CuB) [ion binding]; other site
633149005612	K-pathway; other site
633149005613	Putative proton exit pathway; other site
633149005614	cytochrome c oxidase, subunit II; Region: CoxB; TIGR02866
633149005615	Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; pfam00116
633149005616	Predicted membrane protein (DUF2231); Region: DUF2231; pfam09990
633149005617	Uncharacterized protein family (UPF0093); Region: UPF0093; cl00863
633149005618	Cytochrome c oxidase caa3 assembly factor (Caa3_CtaG); Region: Caa3_CtaG; pfam09678
633149005619	Glucose/sorbosone dehydrogenases [Carbohydrate transport and metabolism]; Region: COG2133
633149005620	TIR domain; Region: TIR_2; pfam13676
633149005621	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
633149005622	cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664
633149005623	ligand binding site [chemical binding]; other site
633149005624	flexible hinge region; other site
633149005625	helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092
633149005626	putative switch regulator; other site
633149005627	non-specific DNA interactions [nucleotide binding]; other site
633149005628	DNA binding site [nucleotide binding]
633149005629	sequence specific DNA binding site [nucleotide binding]; other site
633149005630	putative cAMP binding site [chemical binding]; other site
633149005631	Glycosyl hydrolases family 2, sugar binding domain; Region: Glyco_hydro_2_N; pfam02837
633149005632	Glycosyl hydrolases family 2; Region: Glyco_hydro_2; pfam00703
633149005633	Glycosyl hydrolases family 2, TIM barrel domain; Region: Glyco_hydro_2_C; pfam02836
633149005634	Bacterial Ig-like domain (group 1); Region: Big_1; cl17740
633149005635	TonB-dependent receptor; Region: TonB-Xanth-Caul; TIGR01782
633149005636	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244
633149005637	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
633149005638	Glycosyl hydrolase family 53; Region: Glyco_hydro_53; pfam07745
633149005639	KDPG and KHG aldolase; Region: KDPG_aldolase; cd00452
633149005640	2-dehydro-3-deoxy-6-phosphogalactonate aldolase; Reviewed; Region: PRK09140
633149005641	active site
633149005642	intersubunit interface [polypeptide binding]; other site
633149005643	catalytic residue [active]
633149005644	2-keto-3-deoxy-galactonokinase [Carbohydrate transport and metabolism]; Region: DgoK; COG3734
633149005645	2-keto-3-deoxy-galactonokinase; Region: DGOK; pfam05035
633149005646	Vibrio parahaemolyticus Na(+)/galactose cotransporter (vSGLT) and related proteins; solute binding domain; Region: SLC5sbd_vSGLT; cd10325
633149005647	putative transporter; Provisional; Region: PRK10484
633149005648	Na binding site [ion binding]; other site
633149005649	substrate binding site [chemical binding]; other site
633149005650	Transcriptional regulator [Transcription]; Region: IclR; COG1414
633149005651	IclR helix-turn-helix domain; Region: HTH_IclR; cl17605
633149005652	classical (c) SDRs; Region: SDR_c; cd05233
633149005653	NAD(P) binding site [chemical binding]; other site
633149005654	active site
633149005655	dihydroxy-acid dehydratase; Provisional; Region: PRK13017
633149005656	global nitrogen regulator NtcA, cyanobacterial; Region: NtcA_cyano; TIGR03697
633149005657	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
633149005658	ligand binding site [chemical binding]; other site
633149005659	flexible hinge region; other site
633149005660	helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092
633149005661	putative switch regulator; other site
633149005662	non-specific DNA interactions [nucleotide binding]; other site
633149005663	DNA binding site [nucleotide binding]
633149005664	sequence specific DNA binding site [nucleotide binding]; other site
633149005665	putative cAMP binding site [chemical binding]; other site
633149005666	coproporphyrinogen III oxidase; Provisional; Region: PRK09249
633149005667	HemN C-terminal domain; Region: HemN_C; pfam06969
633149005668	OmpW family; Region: OmpW; pfam03922
633149005669	Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_oxidase; pfam01243
633149005670	KBL_like; this family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to serine palmitoyltransferase (SPT), 5-aminolevulinate synthase (ALAS); Region: KBL_like; cd06454
633149005671	Aminotransferase class I and II; Region: Aminotran_1_2; pfam00155
633149005672	substrate-cofactor binding pocket; other site
633149005673	pyridoxal 5'-phosphate binding site [chemical binding]; other site
633149005674	catalytic residue [active]
633149005675	Cytochrome cbb3 oxidase subunit I.  Cytochrome cbb3 oxidase, the terminal oxidase in the respiratory chains of proteobacteria, is a multi-chain transmembrane protein located in the cell membrane. Like other cytochrome oxidases, it catalyzes the reduction...; Region: cbb3_Oxidase_I; cd01661
633149005676	Low-spin heme binding site [chemical binding]; other site
633149005677	Cytochrome C and Quinol oxidase polypeptide I; Region: COX1; pfam00115
633149005678	Putative water exit pathway; other site
633149005679	Binuclear center (active site) [active]
633149005680	Putative proton exit pathway; other site
633149005681	Cbb3-type cytochrome oxidase, cytochrome c subunit [Energy production and conversion]; Region: CcoO; COG2993
633149005682	Cytochrome C oxidase, mono-heme subunit/FixO; Region: FixO; pfam02433
633149005683	Cytochrome cbb oxidase CcoQ.  Cytochrome cbb3 oxidase, the terminal oxidase in the respiratory chains of proteobacteria, is a multi-chain transmembrane protein located in the cell membrane. Like other cytochrome oxidases, it catalyzes the reduction of O2...; Region: cbb3_Oxidase_CcoQ; cd01324
633149005684	cytochrome c oxidase, cbb3-type, subunit III; Region: ccoP; TIGR00782
633149005685	Cytochrome C oxidase, cbb3-type, subunit III; Region: Cytochrome_CBB3; pfam13442
633149005686	Cytochrome C oxidase, cbb3-type, subunit III; Region: Cytochrome_CBB3; pfam13442
633149005687	cytochrome c oxidase accessory protein FixG; Region: ccoG_rdxA_fixG; TIGR02745
633149005688	The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655
633149005689	Ubp3 associated protein Bre5; Region: Bre5; pfam11614
633149005690	Predicted integral membrane protein linked to a cation pump [Inorganic ion transport and metabolism]; Region: COG5456
633149005691	FixH; Region: FixH; pfam05751
633149005692	Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217
633149005693	Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371
633149005694	metal-binding site [ion binding]
633149005695	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
633149005696	Soluble P-type ATPase [General function prediction only]; Region: COG4087
633149005697	Cytochrome oxidase maturation protein cbb3-type; Region: CcoS; cl01253
633149005698	Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629
633149005699	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
633149005700	N-terminal plug; other site
633149005701	ligand-binding site [chemical binding]; other site
633149005702	Transcriptional regulator [Transcription]; Region: LysR; COG0583
633149005703	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
633149005704	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
633149005705	dimerization interface [polypeptide binding]; other site
633149005706	hypothetical protein; Provisional; Region: PRK06847
633149005707	ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314
633149005708	2,3-dihydroxybiphenyl 1,2-dioxygenase; Region: 23dbph12diox; TIGR03213
633149005709	This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632
633149005710	active site
633149005711	metal binding site [ion binding]; metal-binding site
633149005712	C-terminal, catalytic, domain of BphC5 (2,3-dihydroxybiphenyl 1,2-dioxygenase) from Bacterium Rhodococcus rhodochrous K37 and similar proteins; Region: BphC5-RK37_C_like; cd07239
633149005713	putative active site [active]
633149005714	Mn binding site [ion binding]; other site
633149005715	putative oligomer interface [polypeptide binding]; other site
633149005716	Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695
633149005717	BAAT / Acyl-CoA thioester hydrolase C terminal; Region: BAAT_C; pfam08840
633149005718	Putative cyclase; Region: Cyclase; pfam04199
633149005719	2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179
633149005720	Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557
633149005721	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
633149005722	Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814
633149005723	Dihydroneopterin aldolase; Region: FolB; smart00905
633149005724	active site
633149005725	Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673
633149005726	Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408
633149005727	Subunit B of the Class III extradiol dioxygenase, Protocatechuate 4,5-dioxygenase, which catalyzes the oxidization and subsequent ring-opening of protocatechuate; Region: PCA_45_Dioxygenase_B; cd07364
633149005728	Catalytic LigB subunit of aromatic ring-opening dioxygenase; Region: LigB; pfam02900
633149005729	active site
633149005730	Fe(II) binding site [ion binding]; other site
633149005731	dimer interface [polypeptide binding]; other site
633149005732	tetramer interface [polypeptide binding]; other site
633149005733	The A subunit of Protocatechuate 4,5-dioxygenase (LigAB) is the smaller, non-catalytic subunit; Region: PCA_45_Doxase_A; cd07924
633149005734	dimer interface [polypeptide binding]; other site
633149005735	tetramer interface [polypeptide binding]; other site
633149005736	active site
633149005737	Amidohydrolase; Region: Amidohydro_2; pfam04909
633149005738	3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084
633149005739	Domain of unknown function (DUF1932); Region: DUF1932; pfam09130
633149005740	Transcriptional regulator [Transcription]; Region: LysR; COG0583
633149005741	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
633149005742	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
633149005743	pca operon transcription factor PcaQ; Region: TF_pcaQ; TIGR02424
633149005744	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
633149005745	dimerization interface [polypeptide binding]; other site
633149005746	hypothetical protein; Provisional; Region: PRK09262
633149005747	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2828
633149005748	Predicted metal-dependent hydrolase of the TIM-barrel fold [General function prediction only]; Region: COG3618
633149005749	2-pyrone-4,6-dicarboxylic acid (PDC) hydrolase hydrolyzes PDC to yield 4-oxalomesaconic acid (OMA) or its tautomer, 4-carboxy-2-hydroxymuconic acid (CHM). This reaction is part of the protocatechuate (PCA) 4,5-cleavage pathway. PCA is one of the most...; Region: PDC_hydrolase; cd01311
633149005750	active site
633149005751	CIMS - Cobalamine-independent methonine synthase, or MetE, C-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_C_terminal_like; cd03311
633149005752	substrate binding site [chemical binding]; other site
633149005753	THF binding site; other site
633149005754	zinc-binding site [ion binding]; other site
633149005755	benzoylformate decarboxylase; Reviewed; Region: PRK07092
633149005756	Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035
633149005757	PYR/PP interface [polypeptide binding]; other site
633149005758	dimer interface [polypeptide binding]; other site
633149005759	TPP binding site [chemical binding]; other site
633149005760	Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205
633149005761	Thiamine pyrophosphate (TPP) family, BFDC subfamily, TPP-binding module; composed of proteins similar to Pseudomonas putida benzoylformate decarboxylase (BFDC). P. putida BFDC plays a role in the mandelate pathway, catalyzing the conversion of...; Region: TPP_BFDC; cd02002
633149005762	TPP-binding site [chemical binding]; other site
633149005763	dimer interface [polypeptide binding]; other site
633149005764	Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629
633149005765	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
633149005766	N-terminal plug; other site
633149005767	ligand-binding site [chemical binding]; other site
633149005768	Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cd00531
633149005769	Transcriptional regulator [Transcription]; Region: IclR; COG1414
633149005770	IclR helix-turn-helix domain; Region: HTH_IclR; pfam09339
633149005771	Bacterial transcriptional regulator; Region: IclR; pfam01614
633149005772	Glycine cleavage system T protein (aminomethyltransferase) [Amino acid transport and metabolism]; Region: GcvT; COG0404
633149005773	Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669
633149005774	3-oxoadipate enol-lactonase; Region: protocat_pcaD; TIGR02427
633149005775	homoserine O-acetyltransferase; Provisional; Region: metX; cl17114
633149005776	Methylenetetrahydrofolate reductase (MTHFR). 5,10-Methylenetetrahydrofolate is reduced to 5-methyltetrahydrofolate by methylenetetrahydrofolate reductase, a cytoplasmic, NAD(P)-dependent enzyme. 5-methyltetrahydrofolate is utilized by methionine synthase...; Region: MTHFR; cd00537
633149005777	FAD binding site [chemical binding]; other site
633149005778	formyltetrahydrofolate deformylase; Reviewed; Region: purU; PRK06027
633149005779	N-terminal ACT domain of formyltetrahydrofolate deformylase (F4HF-DF; formyltetrahydrofolate hydrolase); Region: ACT_F4HF-DF; cd04875
633149005780	Formyltetrahydrofolate deformylase (Formyl-FH4 hydrolase), C-terminal hydrolase domain; Region: FMT_core_Formyl-FH4-Hydrolase_C; cd08648
633149005781	putative active site [active]
633149005782	putative substrate binding site [chemical binding]; other site
633149005783	putative cosubstrate binding site; other site
633149005784	catalytic site [active]
633149005785	bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate cyclohydrolase; Provisional; Region: PRK14188
633149005786	Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain; Region: THF_DHG_CYH; pfam00763
633149005787	NADP binding domain of methylene-tetrahydrofolate dehydrogenase/cyclohydrolase; Region: NAD_bind_m-THF_DH_Cyclohyd; cd01080
633149005788	homodimer interface [polypeptide binding]; other site
633149005789	NADP binding site [chemical binding]; other site
633149005790	substrate binding site [chemical binding]; other site
633149005791	NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961
633149005792	Aldehyde dehydrogenase family; Region: Aldedh; pfam00171
633149005793	NAD(P) binding site [chemical binding]; other site
633149005794	catalytic residues [active]
633149005795	benzoate transport; Region: 2A0115; TIGR00895
633149005796	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
633149005797	putative substrate translocation pore; other site
633149005798	catalase/hydroperoxidase HPI(I); Provisional; Region: PRK15061
633149005799	N-terminal catalytic domain of catalase-peroxidases; Region: catalase_peroxidase_1; cd00649
633149005800	dimer interface [polypeptide binding]; other site
633149005801	active site
633149005802	heme binding site [chemical binding]; other site
633149005803	C-terminal non-catalytic domain of catalase-peroxidases; Region: catalase_peroxidase_2; cd08200
633149005804	CTP synthetase; Validated; Region: pyrG; PRK05380
633149005805	CTP synthetase (CTPs) is a two-domain protein, which consists of an N-terminal synthetase domain and C-terminal glutaminase domain. The enzymes hydrolyze the amide bond of glutamine to ammonia and glutamate at the glutaminase domains and transfer nascent...; Region: CTGs; cd03113
633149005806	Catalytic site [active]
633149005807	active site
633149005808	UTP binding site [chemical binding]; other site
633149005809	Type 1 glutamine amidotransferase (GATase1) domain found in Cytidine Triphosphate Synthetase; Region: GATase1_CTP_Synthase; cd01746
633149005810	active site
633149005811	putative oxyanion hole; other site
633149005812	catalytic triad [active]
633149005813	Triosephosphate isomerase (TIM) is a glycolytic enzyme that catalyzes the interconversion of dihydroxyacetone phosphate and D-glyceraldehyde-3-phosphate. The reaction is very efficient and requires neither cofactors nor metal ions. TIM, usually...; Region: TIM; cd00311
633149005814	substrate binding site [chemical binding]; other site
633149005815	dimer interface [polypeptide binding]; other site
633149005816	catalytic triad [active]
633149005817	SurA N-terminal domain; Region: SurA_N_3; cl07813
633149005818	PPIC-type PPIASE domain; Region: Rotamase_2; pfam13145
633149005819	PPIC-type PPIASE domain; Region: Rotamase_2; pfam13145
633149005820	anthranilate synthase component I; Provisional; Region: PRK13573
633149005821	Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715
633149005822	chorismate binding enzyme; Region: Chorismate_bind; pfam00425
633149005823	para-aminobenzoate synthase component II; Provisional; Region: PRK08857
633149005824	Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743
633149005825	glutamine binding [chemical binding]; other site
633149005826	catalytic triad [active]
633149005827	anthranilate phosphoribosyltransferase; Provisional; Region: trpD; PRK00188
633149005828	Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885
633149005829	Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591
633149005830	Indole-3-glycerol phosphate synthase (IGPS); an enzyme in the tryptophan biosynthetic pathway, catalyzing the ring closure reaction of 1-(o-carboxyphenylamino)-1-deoxyribulose-5-phosphate (CdRP) to indole-3-glycerol phosphate (IGP), accompanied by the...; Region: IGPS; cd00331
633149005831	active site
633149005832	ribulose/triose binding site [chemical binding]; other site
633149005833	phosphate binding site [ion binding]; other site
633149005834	substrate (anthranilate) binding pocket [chemical binding]; other site
633149005835	product (indole) binding pocket [chemical binding]; other site
633149005836	LexA repressor; Validated; Region: PRK00215
633149005837	LexA DNA binding domain; Region: LexA_DNA_bind; pfam01726
633149005838	Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529
633149005839	Catalytic site [active]
633149005840	Predicted membrane metal-binding protein [General function prediction only]; Region: ComEC; COG0658
633149005841	Competence protein; Region: Competence; pfam03772
633149005842	glutamyl-tRNA synthetase; Reviewed; Region: gltX; PRK01406
633149005843	catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808
633149005844	HIGH motif; other site
633149005845	catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808
633149005846	active site
633149005847	KMSKS motif; other site
633149005848	Escherichia coli (Ec) citrate synthase (CS) GltA_like. CS catalyzes the condensation of acetyl coenzyme A (AcCoA) and oxalacetate (OAA) to form citrate and coenzyme A (CoA), the first step in the citric acid cycle (TCA or Krebs cycle). The overall CS...; Region: EcCS_like; cd06114
633149005849	Citrate synthase [Energy production and conversion]; Region: GltA; COG0372
633149005850	dimer interface [polypeptide binding]; other site
633149005851	active site
633149005852	citrylCoA binding site [chemical binding]; other site
633149005853	NADH binding [chemical binding]; other site
633149005854	cationic pore residues; other site
633149005855	oxalacetate/citrate binding site [chemical binding]; other site
633149005856	coenzyme A binding site [chemical binding]; other site
633149005857	catalytic triad [active]
633149005858	Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cd00143
633149005859	active site
633149005860	Protein kinase domain; Region: Pkinase; pfam00069
633149005861	Catalytic domain of Protein Kinases; Region: PKc; cd00180
633149005862	active site
633149005863	ATP binding site [chemical binding]; other site
633149005864	substrate binding site [chemical binding]; other site
633149005865	activation loop (A-loop); other site
633149005866	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3814
633149005867	Peptidase C13 family; Region: Peptidase_C13; cl02159
633149005868	Endodeoxyribonuclease RusA; Region: RusA; cl01885
633149005869	peptidyl-prolyl cis-trans isomerase A (rotamase A); Provisional; Region: PRK10903
633149005870	cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the...; Region: cyclophilin; cd00317
633149005871	active site
633149005872	fumarate hydratase; Reviewed; Region: fumC; PRK00485
633149005873	Class II fumarases; Region: Fumarase_classII; cd01362
633149005874	active site
633149005875	tetramer interface [polypeptide binding]; other site
633149005876	Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596
633149005877	Putative lysophospholipase; Region: Hydrolase_4; pfam12146
633149005878	Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326
633149005879	hypothetical protein; Provisional; Region: PRK11770
633149005880	Domain of unknown function (DUF307); Region: DUF307; pfam03733
633149005881	Domain of unknown function (DUF307); Region: DUF307; pfam03733
633149005882	Uncharacterized protein conserved in bacteria (DUF2171); Region: DUF2171; pfam09939
633149005883	Domain of unknown function (DUF4169); Region: DUF4169; pfam13770
633149005884	putative DMT superfamily transporter inner membrane protein; Provisional; Region: PRK11272
633149005885	EamA-like transporter family; Region: EamA; pfam00892
633149005886	Coenzyme Q (ubiquinone) biosynthesis protein Coq4; Region: Coq4; cl02093
633149005887	Predicted naringenin-chalcone synthase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: BcsA; COG3424
633149005888	Chalcone and stilbene synthases; plant-specific polyketide synthases (PKS) and related enzymes, also called type III PKSs. PKS generate an array of different products, dependent on the nature of the starter molecule. They share a common chemical strategy; Region: CHS_like; cd00831
633149005889	malonyl-CoA binding site [chemical binding]; other site
633149005890	dimer interface [polypeptide binding]; other site
633149005891	active site
633149005892	product binding site; other site
633149005893	Phospholipid methyltransferase; Region: PEMT; cl17370
633149005894	Ribbon-helix-helix domain; Region: RHH_4; pfam13467
633149005895	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2859
633149005896	ATP-dependent DNA helicase PcrA; Region: pcrA; TIGR01073
633149005897	Part of AAA domain; Region: AAA_19; pfam13245
633149005898	Family description; Region: UvrD_C_2; pfam13538
633149005899	helicase 45; Provisional; Region: PTZ00424
633149005900	DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker  B motif; Region: DEADc; cd00268
633149005901	ATP binding site [chemical binding]; other site
633149005902	Mg++ binding site [ion binding]; other site
633149005903	motif III; other site
633149005904	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
633149005905	nucleotide binding region [chemical binding]; other site
633149005906	ATP-binding site [chemical binding]; other site
633149005907	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
633149005908	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
633149005909	metal binding site [ion binding]; metal-binding site
633149005910	active site
633149005911	I-site; other site
633149005912	1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204
633149005913	Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989
633149005914	putative acyl-acceptor binding pocket; other site
633149005915	TfoX N-terminal domain; Region: TfoX_N; pfam04993
633149005916	ABC-type metal ion transport system, periplasmic component/surface antigen [Inorganic ion transport and metabolism]; Region: NlpA; COG1464
633149005917	NLPA lipoprotein; Region: Lipoprotein_9; pfam03180
633149005918	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
633149005919	dimer interface [polypeptide binding]; other site
633149005920	conserved gate region; other site
633149005921	ABC-ATPase subunit interface; other site
633149005922	DL-methionine transporter ATP-binding subunit; Provisional; Region: metN; PRK11153
633149005923	ATP-binding cassette domain of methionine transporter; Region: ABC_MetN_methionine_transporter; cd03258
633149005924	Walker A/P-loop; other site
633149005925	ATP binding site [chemical binding]; other site
633149005926	Q-loop/lid; other site
633149005927	ABC transporter signature motif; other site
633149005928	Walker B; other site
633149005929	D-loop; other site
633149005930	H-loop/switch region; other site
633149005931	This domain is found at the C-terminus of ABC transporter proteins involved in D-methionine transport as well as a number of ferredoxin-like proteins; Region: NIL; smart00930
633149005932	Fe-S cluster assembly scaffold protein [Posttranslational modification, protein turnover, chaperones]; Region: sufA; COG0316
633149005933	FeS assembly SUF system protein; Region: SUF_assoc; TIGR02945
633149005934	Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520
633149005935	Cysteine desulfurase (SufS)-like. This family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to cysteine desulfurase (SufS) and selenocysteine lyase. SufS...; Region: SufS_like; cd06453
633149005936	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
633149005937	catalytic residue [active]
633149005938	FeS assembly protein SufD; Region: sufD; TIGR01981
633149005939	Uncharacterized protein family (UPF0051); Region: UPF0051; pfam01458
633149005940	FeS assembly ATPase SufC; Region: sufC; TIGR01978
633149005941	ABC-type transport system involved in Fe-S cluster assembly, ATPase component; Region: ABC_FeS_Assembly; cd03217
633149005942	Walker A/P-loop; other site
633149005943	ATP binding site [chemical binding]; other site
633149005944	Q-loop/lid; other site
633149005945	ABC transporter signature motif; other site
633149005946	Walker B; other site
633149005947	D-loop; other site
633149005948	H-loop/switch region; other site
633149005949	cysteine desulfurase activator complex subunit SufB; Provisional; Region: PRK11814
633149005950	putative ABC transporter; Region: ycf24; CHL00085
633149005951	Cysteine sulfinate desulfinase/cysteine desulfurase and related enzymes [Amino acid transport and metabolism]; Region: NifS; COG1104
633149005952	cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402
633149005953	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
633149005954	catalytic residue [active]
633149005955	Transcriptional regulator; Region: Rrf2; cl17282
633149005956	Rrf2 family protein; Region: rrf2_super; TIGR00738
633149005957	Predicted hydrolase of the alpha/beta superfamily [General function prediction only]; Region: COG2945
633149005958	Eukaryotic protein of unknown function (DUF829); Region: DUF829; pfam05705
633149005959	Protein of unknown function (DUF1343); Region: DUF1343; pfam07075
633149005960	Domon-like domain of UDP-N-acetylenolpyruvoylglucosamine reductase; Region: DOMON_murB_like; cd09627
633149005961	putative heme binding site [chemical binding]; other site
633149005962	tyrosyl-tRNA synthetase; Validated; Region: PRK05912
633149005963	catalytic core domain of tyrosinyl-tRNA synthetase; Region: TyrRS_core; cd00805
633149005964	active site
633149005965	HIGH motif; other site
633149005966	dimer interface [polypeptide binding]; other site
633149005967	KMSKS motif; other site
633149005968	Peroxiredoxin (PRX) family, Bacterioferritin comigratory protein (BCP) subfamily; composed of thioredoxin-dependent thiol peroxidases, widely expressed in pathogenic bacteria, that protect cells against toxicity from reactive oxygen species by reducing...; Region: PRX_BCP; cd03017
633149005969	catalytic triad [active]
633149005970	Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739
633149005971	Peptidase family M23; Region: Peptidase_M23; pfam01551
633149005972	Polymer-forming cytoskeletal; Region: Bactofilin; pfam04519
633149005973	peptide chain release factor 2; Validated; Region: prfB; PRK00578
633149005974	This domain is found in peptide chain release factors; Region: PCRF; smart00937
633149005975	RF-1 domain; Region: RF-1; pfam00472
633149005976	Membrane carboxypeptidase/penicillin-binding protein [Cell envelope biogenesis, outer membrane]; Region: MrcA; COG5009
633149005977	Transglycosylase; Region: Transgly; pfam00912
633149005978	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905
633149005979	N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860
633149005980	N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696
633149005981	active site
633149005982	metal binding site [ion binding]; metal-binding site
633149005983	Ribonucleases G and E [Translation, ribosomal structure and biogenesis]; Region: CafA; COG1530
633149005984	S1_RNase_E: RNase E and RNase G, S1-like RNA-binding domain. RNase E is an essential endoribonuclease in the processing and degradation of RNA. In addition to its role in mRNA degradation, RNase E has also been implicated in the processing of rRNA, and...; Region: S1_RNase_E; cd04453
633149005985	homodimer interface [polypeptide binding]; other site
633149005986	oligonucleotide binding site [chemical binding]; other site
633149005987	Peptidase family M48; Region: Peptidase_M48; pfam01435
633149005988	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
633149005989	binding surface
633149005990	TPR motif; other site
633149005991	TPR repeat; Region: TPR_11; pfam13414
633149005992	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
633149005993	binding surface
633149005994	TPR motif; other site
633149005995	Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388
633149005996	DSBA-like thioredoxin domain; Region: DSBA; pfam01323
633149005997	CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; pfam01066
633149005998	Protein of unknown function (DUF3224); Region: DUF3224; pfam11528
633149005999	Thiazole synthase (ThiG) is the tetrameric enzyme that is involved in the formation of the thiazole moiety of thiamin pyrophosphate, an essential ubiquitous cofactor that plays an important role in carbohydrate and amino acid metabolism. ThiG catalyzes...; Region: ThiG; cd04728
633149006000	ThiS interaction site; other site
633149006001	putative active site [active]
633149006002	tetramer interface [polypeptide binding]; other site
633149006003	ThiaminS ubiquitin-like sulfur carrier protein; Region: ThiS; cd00565
633149006004	thiS-thiF/thiG interaction site; other site
633149006005	Dehydroquinase (DHQase), type II. Dehydroquinase (or 3-dehydroquinate dehydratase) catalyzes the reversible dehydration of 3-dehydroquinate to form 3-dehydroshikimate. This reaction is part of two metabolic pathways: the biosynthetic shikimate pathway...; Region: DHQase_II; cd00466
633149006006	Dehydroquinase class II; Region: DHquinase_II; pfam01220
633149006007	active site
633149006008	trimer interface [polypeptide binding]; other site
633149006009	dimer interface [polypeptide binding]; other site
633149006010	acetyl-CoA carboxylase biotin carboxyl carrier protein subunit; Validated; Region: PRK06302
633149006011	The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850
633149006012	carboxyltransferase (CT) interaction site; other site
633149006013	biotinylation site [posttranslational modification]; other site
633149006014	acetyl-CoA carboxylase biotin carboxylase subunit; Validated; Region: PRK08591
633149006015	Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289
633149006016	Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786
633149006017	Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878
633149006018	leucyl/phenylalanyl-tRNA--protein transferase; Reviewed; Region: aat; PRK00301
633149006019	Uncharacterized protein conserved in bacteria (DUF2155); Region: DUF2155; cl01970
633149006020	NADH dehydrogenase; Validated; Region: PRK08183
633149006021	TSCPD domain; Region: TSCPD; pfam12637
633149006022	Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599
633149006023	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
633149006024	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
633149006025	Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599
633149006026	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
633149006027	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
633149006028	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
633149006029	Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599
633149006030	Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599
633149006031	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
633149006032	aspartyl-tRNA synthetase; Validated; Region: aspS; PRK00476
633149006033	EcAspRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli aspartyl-tRNA synthetase (AspRS), the human mitochondrial (mt) AspRS-2, the discriminating (D) Thermus thermophilus AspRS-1, and the nondiscriminating (ND)...; Region: EcAspRS_like_N; cd04317
633149006034	dimer interface [polypeptide binding]; other site
633149006035	anticodon binding site; other site
633149006036	Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of...; Region: AspRS_core; cd00777
633149006037	homodimer interface [polypeptide binding]; other site
633149006038	motif 1; other site
633149006039	active site
633149006040	motif 2; other site
633149006041	GAD domain; Region: GAD; pfam02938
633149006042	Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA.   PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268
633149006043	active site
633149006044	motif 3; other site
633149006045	ATPase involved in DNA replication initiation [DNA replication, recombination, and repair]; Region: DnaA; COG0593
633149006046	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189
633149006047	polyphosphate kinase; Provisional; Region: PRK05443
633149006048	Polyphosphate kinase N-terminal domain; Region: PP_kinase_N; pfam13089
633149006049	Polyphosphate kinase middle domain; Region: PP_kinase; pfam02503
633149006050	Catalytic C-terminal domain, first repeat, of Pseudomonas aeruginosa polyphosphate kinase 1 and similar proteins; Region: PLDc_PaPPK1_C1_like; cd09165
633149006051	putative domain interface [polypeptide binding]; other site
633149006052	putative active site [active]
633149006053	catalytic site [active]
633149006054	Catalytic C-terminal domain, second repeat, of Pseudomonas aeruginosa polyphosphate kinase 1 and similar proteins; Region: PLDc_PaPPK1_C2_like; cd09168
633149006055	putative domain interface [polypeptide binding]; other site
633149006056	putative active site [active]
633149006057	catalytic site [active]
633149006058	Exopolyphosphatase [Nucleotide transport and metabolism / Inorganic ion transport and metabolism]; Region: GppA; COG0248
633149006059	Ppx/GppA phosphatase family; Region: Ppx-GppA; pfam02541
633149006060	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
633149006061	This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587
633149006062	active site
633149006063	ribonuclease D; Region: rnd; TIGR01388
633149006064	DEDDy 3'-5' exonuclease domain of Ribonuclease D and similar proteins; Region: RNaseD_exo; cd06142
633149006065	catalytic site [active]
633149006066	putative active site [active]
633149006067	putative substrate binding site [chemical binding]; other site
633149006068	HRDC domain; Region: HRDC; pfam00570
633149006069	phosphoribosylaminoimidazole synthetase; Provisional; Region: PRK05385
633149006070	PurM (Aminoimidazole Ribonucleotide [AIR] synthetase), one of eleven enzymes required for purine biosynthesis, catalyzes the conversion of formylglycinamide ribonucleotide (FGAM) and ATP to AIR, ADP, and Pi, the fifth step in de novo purine biosynthesis; Region: PurM; cd02196
633149006071	dimerization interface [polypeptide binding]; other site
633149006072	putative ATP binding site [chemical binding]; other site
633149006073	M28 Zn-Peptidase Aeromonas (Vibrio) proteolytica aminopeptidase (AAP)-like; Region: M28_AAP_like; cd05642
633149006074	Predicted aminopeptidases [General function prediction only]; Region: Iap; COG2234
633149006075	putative metal binding site [ion binding]; other site
633149006076	Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063
633149006077	Interdomain contacts; other site
633149006078	phosphoribosylglycinamide formyltransferase; Reviewed; Region: purN; PRK05647
633149006079	Phosphoribosylglycinamide formyltransferase (GAR transformylase, GART); Region: FMT_core_GART; cd08645
633149006080	active site
633149006081	substrate binding site [chemical binding]; other site
633149006082	cosubstrate binding site; other site
633149006083	catalytic site [active]
633149006084	Predicted metalloendopeptidase [Posttranslational modification, protein turnover, chaperones]; Region: PepO; COG3590
633149006085	Peptidase family M13 includes neprilysin, endothelin-converting enzyme I; Region: M13; cd08662
633149006086	active site
633149006087	Zn binding site [ion binding]; other site
633149006088	Nucleoside diphosphate kinase Group I (NDPk_I)-like: NDP kinase domains are present in a large family of structurally and functionally conserved proteins from bacteria to humans that generally catalyze the transfer of gamma-phosphates of a nucleoside...; Region: NDPk_I; cd04413
633149006089	active site
633149006090	multimer interface [polypeptide binding]; other site
633149006091	ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488
633149006092	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
633149006093	Walker A/P-loop; other site
633149006094	ATP binding site [chemical binding]; other site
633149006095	Q-loop/lid; other site
633149006096	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
633149006097	ABC transporter signature motif; other site
633149006098	Walker B; other site
633149006099	D-loop; other site
633149006100	ABC transporter; Region: ABC_tran_2; pfam12848
633149006101	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
633149006102	Uncharacterized conserved protein (DUF2164); Region: DUF2164; pfam09932
633149006103	Uncharacterized protein conserved in bacteria (DUF2093); Region: DUF2093; cl11535
633149006104	Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739
633149006105	Peptidase family M23; Region: Peptidase_M23; pfam01551
633149006106	Response regulator receiver domain; Region: Response_reg; pfam00072
633149006107	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
633149006108	active site
633149006109	phosphorylation site [posttranslational modification]
633149006110	intermolecular recognition site; other site
633149006111	dimerization interface [polypeptide binding]; other site
633149006112	Bacterial lipid A biosynthesis acyltransferase; Region: Lip_A_acyltrans; pfam03279
633149006113	Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LABLAT-like; Region: LPLAT_LABLAT-like; cd07984
633149006114	putative acyl-acceptor binding pocket; other site
633149006115	3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK07231
633149006116	classical (c) SDRs; Region: SDR_c; cd05233
633149006117	NAD(P) binding site [chemical binding]; other site
633149006118	active site
633149006119	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
633149006120	SnoaL-like domain; Region: SnoaL_3; pfam13474
633149006121	PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria.  Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443
633149006122	CoenzymeA binding site [chemical binding]; other site
633149006123	subunit interaction site [polypeptide binding]; other site
633149006124	PHB binding site; other site
633149006125	Protein of unknown function (DUF3035); Region: DUF3035; pfam11233
633149006126	lipoprotein signal peptidase; Reviewed; Region: lspA; PRK00376
633149006127	lipoprotein signal peptidase; Provisional; Region: PRK14787
633149006128	HAD-superfamily class IIA hydrolase, TIGR01459; Region: HAD-SF-IIA-hyp4
633149006129	Haloacid dehalogenase-like hydrolase; Region: Hydrolase_6; pfam13344
633149006130	(R)-hydratase [(R)-specific enoyl-CoA hydratase] catalyzes the hydration of trans-2-enoyl CoA to (R)-3-hydroxyacyl-CoA as part of the PHA (polyhydroxyalkanoate) biosynthetic pathway. (R)-hydratase contains a hot-dog fold similar to those of thioesterase...; Region: R_hydratase; cd03449
633149006131	dimer interaction site [polypeptide binding]; other site
633149006132	substrate-binding tunnel; other site
633149006133	active site
633149006134	catalytic site [active]
633149006135	substrate binding site [chemical binding]; other site
633149006136	bifunctional riboflavin kinase/FMN adenylyltransferase; Reviewed; Region: PRK05627
633149006137	FAD synthetase, N-terminal domain of the bifunctional enzyme; Region: FAD_synthetase_N; cd02064
633149006138	active site
633149006139	Riboflavin kinase; Region: Flavokinase; pfam01687
633149006140	isoleucyl-tRNA synthetase; Provisional; Region: ileS; PRK13804
633149006141	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
633149006142	active site
633149006143	HIGH motif; other site
633149006144	nucleotide binding site [chemical binding]; other site
633149006145	catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818
633149006146	active site
633149006147	KMSKS motif; other site
633149006148	Anticodon-binding domain of bacterial and eukaryotic mitochondrial isoleucyl tRNA synthetases; Region: Anticodon_Ia_Ile_BEm; cd07960
633149006149	tRNA binding surface [nucleotide binding]; other site
633149006150	anticodon binding site; other site
633149006151	Uncharacterized conserved protein [Function unknown]; Region: COG5590
633149006152	COQ9; Region: COQ9; pfam08511
633149006153	30S ribosomal protein S21; Reviewed; Region: rpsU; PRK00270
633149006154	ABC-type Na+ efflux pump, permease component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatB; COG1668
633149006155	ABC-type transport system involved in multi-copper enzyme maturation, permease component [General function prediction only]; Region: NosY; COG1277
633149006156	ABC-type uncharacterized transport system, ATPase component [General function prediction only]; Region: COG4152
633149006157	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
633149006158	Walker A/P-loop; other site
633149006159	ATP binding site [chemical binding]; other site
633149006160	Q-loop/lid; other site
633149006161	ABC transporter signature motif; other site
633149006162	Walker B; other site
633149006163	D-loop; other site
633149006164	H-loop/switch region; other site
633149006165	Domain of unknown function (DUF4162); Region: DUF4162; pfam13732
633149006166	Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739
633149006167	Peptidase family M23; Region: Peptidase_M23; pfam01551
633149006168	hypothetical protein; Provisional; Region: PRK02853
633149006169	Protein of unknown function (DUF2948); Region: DUF2948; pfam11164
633149006170	UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Region: murA; TIGR01072
633149006171	UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555
633149006172	hinge; other site
633149006173	active site
633149006174	methionine sulfoxide reductase B; Provisional; Region: PRK00222
633149006175	SelR domain; Region: SelR; pfam01641
633149006176	Acetyl/propionyl-CoA carboxylase, alpha subunit [Lipid metabolism]; Region: COG4770
633149006177	Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289
633149006178	Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786
633149006179	Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878
633149006180	The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850
633149006181	carboxyltransferase (CT) interaction site; other site
633149006182	biotinylation site [posttranslational modification]; other site
633149006183	Threonine aldolase [Amino acid transport and metabolism]; Region: GLY1; COG2008
633149006184	Low-specificity threonine aldolase (TA). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I).  TA catalyzes the conversion of L-threonine or L-allo-threonine to glycine and acetaldehyde in a...; Region: TA_like; cd06502
633149006185	tetramer interface [polypeptide binding]; other site
633149006186	pyridoxal 5'-phosphate binding site [chemical binding]; other site
633149006187	catalytic residue [active]
633149006188	Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668
633149006189	Mechanosensitive ion channel; Region: MS_channel; pfam00924
633149006190	ATP-dependent DNA ligase; Validated; Region: PRK09247
633149006191	Adenylation domain of putative bacterial ATP-dependent DNA ligases; Region: Adenylation_DNA_ligase_Bac1; cd07897
633149006192	active site
633149006193	DNA binding site [nucleotide binding]
633149006194	The Oligonucleotide/oligosaccharide binding (OB)-fold domain of archaeal and bacterial ATP-dependent DNA ligases is a DNA-binding module that is part of the catalytic core unit; Region: OBF_DNA_ligase_Arch_LigB; cd07972
633149006195	DNA binding site [nucleotide binding]
633149006196	Domain of unknown function (DUF3315); Region: DUF3315; cl02275
633149006197	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
633149006198	Protein of unknown function (DUF421); Region: DUF421; cl00990
633149006199	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
633149006200	dimer interface [polypeptide binding]; other site
633149006201	phosphorylation site [posttranslational modification]
633149006202	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
633149006203	ATP binding site [chemical binding]; other site
633149006204	Mg2+ binding site [ion binding]; other site
633149006205	G-X-G motif; other site
633149006206	Response regulator receiver domain; Region: Response_reg; pfam00072
633149006207	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
633149006208	active site
633149006209	phosphorylation site [posttranslational modification]
633149006210	intermolecular recognition site; other site
633149006211	dimerization interface [polypeptide binding]; other site
633149006212	BolA-like protein; Region: BolA; pfam01722
633149006213	DnaJ domain or J-domain.  DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257
633149006214	HSP70 interaction site [polypeptide binding]; other site
633149006215	peroxiredoxin, Ohr subfamily; Region: organ_hyd_perox; TIGR03561
633149006216	cobaltochelatase, CobS subunit; Region: PD_CobS; TIGR01650
633149006217	Cobaltochelatase CobS subunit N terminal; Region: CobS_N; pfam12556
633149006218	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189
633149006219	F5/8 type C domain; Region: F5_F8_type_C; pfam00754
633149006220	ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395
633149006221	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
633149006222	dimer interface [polypeptide binding]; other site
633149006223	conserved gate region; other site
633149006224	putative PBP binding loops; other site
633149006225	ABC-ATPase subunit interface; other site
633149006226	ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209
633149006227	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
633149006228	dimer interface [polypeptide binding]; other site
633149006229	conserved gate region; other site
633149006230	putative PBP binding loops; other site
633149006231	ABC-ATPase subunit interface; other site
633149006232	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653
633149006233	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547
633149006234	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5368
633149006235	Putative glucoamylase; Region: Glycoamylase; pfam10091
633149006236	Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620
633149006237	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244
633149006238	Transcriptional regulators [Transcription]; Region: PurR; COG1609
633149006239	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
633149006240	DNA binding site [nucleotide binding]
633149006241	domain linker motif; other site
633149006242	Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267
633149006243	dimerization interface [polypeptide binding]; other site
633149006244	ligand binding site [chemical binding]; other site
633149006245	Carboxylesterase family; Region: COesterase; pfam00135
633149006246	Esterases and lipases (includes fungal lipases, cholinesterases, etc.)  These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312
633149006247	substrate binding pocket [chemical binding]; other site
633149006248	catalytic triad [active]
633149006249	FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784
633149006250	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
633149006251	active site
633149006252	phosphorylation site [posttranslational modification]
633149006253	intermolecular recognition site; other site
633149006254	dimerization interface [polypeptide binding]; other site
633149006255	Phytoene dehydrogenase and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG1233
633149006256	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
633149006257	hydroxyglutarate oxidase; Provisional; Region: PRK11728
633149006258	isopentenyl pyrophosphate isomerase; Provisional; Region: PRK05437
633149006259	Isopentenyl-diphosphate:dimethylallyl diphosphate isomerase type 2 (IDI-2) FMN-binding domain. Two types of IDIs have been characterized at present. The long known IDI-1 is only dependent on divalent metals for activity, whereas IDI-2 requires a metal; Region: IDI-2_FMN; cd02811
633149006260	homotetramer interface [polypeptide binding]; other site
633149006261	FMN binding site [chemical binding]; other site
633149006262	homodimer contacts [polypeptide binding]; other site
633149006263	putative active site [active]
633149006264	putative substrate binding site [chemical binding]; other site
633149006265	beta-carotene hydroxylase; Region: PLN02601
633149006266	The membrane fatty acid desaturase (Membrane_FADS)-like CD includes membrane FADSs, alkane hydroxylases, beta carotene ketolases (CrtW-like), hydroxylases (CrtR-like), and other related proteins. They are present in all groups of organisms with the...; Region: Membrane-FADS-like; cl00615
633149006267	putative di-iron ligands [ion binding]; other site
633149006268	Trans-Isoprenyl Diphosphate Synthases, head-to-head; Region: Trans_IPPS_HH; cd00683
633149006269	active site lid residues [active]
633149006270	substrate binding pocket [chemical binding]; other site
633149006271	catalytic residues [active]
633149006272	substrate-Mg2+ binding site; other site
633149006273	aspartate-rich region 1; other site
633149006274	aspartate-rich region 2; other site
633149006275	phytoene desaturase; Region: crtI_fam; TIGR02734
633149006276	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
633149006277	Lycopene cyclase protein; Region: Lycopene_cycl; pfam05834
633149006278	lycopene cyclase; Region: lycopene_cycl; TIGR01789
633149006279	bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate cyclohydrolase; Provisional; Region: PRK14188
633149006280	Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain; Region: THF_DHG_CYH; pfam00763
633149006281	NADP binding domain of methylene-tetrahydrofolate dehydrogenase/cyclohydrolase; Region: NAD_bind_m-THF_DH_Cyclohyd; cd01080
633149006282	homodimer interface [polypeptide binding]; other site
633149006283	NADP binding site [chemical binding]; other site
633149006284	substrate binding site [chemical binding]; other site
633149006285	Uncharacterized conserved protein [Function unknown]; Region: LemA; COG1704
633149006286	Repair protein; Region: Repair_PSII; pfam04536
633149006287	Repair protein; Region: Repair_PSII; cl01535
633149006288	Metal-dependent hydrolase [General function prediction only]; Region: ElsH; COG3568
633149006289	putative catalytic site [active]
633149006290	putative metal binding site [ion binding]; other site
633149006291	putative phosphate binding site [ion binding]; other site
633149006292	Catalytic domain, repeat 1, of uncharacterized bacterial proteins with similarity to vertebrate phospholipases, PLD1 and PLD2; Region: PLDc_vPLD1_2_like_bac_1; cd09140
633149006293	putative active site [active]
633149006294	catalytic site [active]
633149006295	Catalytic domain, repeat 2, of uncharacterized bacterial proteins with similarity to vertebrate phospholipases, PLD1 and PLD2; Region: PLDc_vPLD1_2_like_bac_2; cd09143
633149006296	PLD-like domain; Region: PLDc_2; pfam13091
633149006297	putative active site [active]
633149006298	catalytic site [active]
633149006299	putative 3-phenylpropionic acid transporter; Provisional; Region: PRK11128
633149006300	MFS_1 like family; Region: MFS_1_like; pfam12832
633149006301	Uncharacterized small membrane protein [Function unknown]; Region: COG2363
633149006302	proline iminopeptidase, Neisseria-type subfamily; Region: pro_imino_pep_1; TIGR01249
633149006303	homoserine O-acetyltransferase; Provisional; Region: metX; cl17114
633149006304	TAP-like protein; Region: Abhydrolase_4; pfam08386
633149006305	rod shape-determining protein RodA; Region: rodA_shape; TIGR02210
633149006306	penicillin-binding protein 2; Region: pbp2_mrdA; TIGR03423
633149006307	Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717
633149006308	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905
633149006309	rod shape-determining protein MreC; Provisional; Region: PRK13922
633149006310	rod shape-determining protein MreC; Region: MreC; pfam04085
633149006311	rod shape-determining protein MreB; Provisional; Region: PRK13927
633149006312	MreB and similar proteins; Region: MreB_like; cd10225
633149006313	nucleotide binding site [chemical binding]; other site
633149006314	Mg binding site [ion binding]; other site
633149006315	putative protofilament interaction site [polypeptide binding]; other site
633149006316	RodZ interaction site [polypeptide binding]; other site
633149006317	glutathionine S-transferase; Provisional; Region: PRK10542
633149006318	GST_N family, Class Beta subfamily; GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of endogenous and xenobiotic alkylating agents, including carcinogens; Region: GST_N_Beta; cd03057
633149006319	C-terminal domain interface [polypeptide binding]; other site
633149006320	GSH binding site (G-site) [chemical binding]; other site
633149006321	dimer interface [polypeptide binding]; other site
633149006322	C-terminal, alpha helical domain of Class Beta Glutathione S-transferases; Region: GST_C_Beta; cd03188
633149006323	N-terminal domain interface [polypeptide binding]; other site
633149006324	dimer interface [polypeptide binding]; other site
633149006325	substrate binding pocket (H-site) [chemical binding]; other site
633149006326	Uncharacterized conserved protein [Function unknown]; Region: COG0398
633149006327	SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335
633149006328	aspartate aminotransferase; Provisional; Region: PRK05764
633149006329	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
633149006330	pyridoxal 5'-phosphate binding site [chemical binding]; other site
633149006331	homodimer interface [polypeptide binding]; other site
633149006332	catalytic residue [active]
633149006333	Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142
633149006334	Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685
633149006335	substrate binding pocket [chemical binding]; other site
633149006336	chain length determination region; other site
633149006337	substrate-Mg2+ binding site; other site
633149006338	catalytic residues [active]
633149006339	aspartate-rich region 1; other site
633149006340	active site lid residues [active]
633149006341	aspartate-rich region 2; other site
633149006342	Predicted O-methyltransferase [General function prediction only]; Region: COG4123
633149006343	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
633149006344	S-adenosylmethionine binding site [chemical binding]; other site
633149006345	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
633149006346	Imidazolonepropionase and related amidohydrolases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: HutI; COG1228
633149006347	Metallo-dependent hydrolases, subgroup A is part of the superfamily of metallo-dependent hydrolases, a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the...; Region: Met_dep_hydrolase_A; cd01299
633149006348	active site
633149006349	Putative 2OG-Fe(II) oxygenase; Region: 2OG-FeII_Oxy_5; cl17879
633149006350	classical (c) SDRs; Region: SDR_c; cd05233
633149006351	NAD(P) binding site [chemical binding]; other site
633149006352	active site
633149006353	RNA polymerase sigma factor; Provisional; Region: PRK12536
633149006354	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
633149006355	Sigma-70, region 4; Region: Sigma70_r4_2; pfam08281
633149006356	Protein of unknown function (DUF1109); Region: DUF1109; cl02071
633149006357	putative ABC transporter ATP-binding protein; Reviewed; Region: PRK11819
633149006358	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
633149006359	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
633149006360	Walker A/P-loop; other site
633149006361	ATP binding site [chemical binding]; other site
633149006362	Q-loop/lid; other site
633149006363	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
633149006364	ABC transporter signature motif; other site
633149006365	Walker B; other site
633149006366	ABC transporter; Region: ABC_tran_2; pfam12848
633149006367	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
633149006368	glucosyltransferase MdoH; Provisional; Region: PRK05454
633149006369	active site
633149006370	Protein of unknown function (DUF998); Region: DUF998; pfam06197
633149006371	Predicted membrane protein [Function unknown]; Region: COG3371
633149006372	glucans biosynthesis protein; Provisional; Region: opgC; PRK03854
633149006373	Acyltransferase family; Region: Acyl_transf_3; pfam01757
633149006374	Chagasin family peptidase inhibitor I42; Region: Inhibitor_I42; pfam09394
633149006375	glyoxylate reductase; Reviewed; Region: PRK13243
633149006376	Hydroxy(phenyl)pyruvate Reductase, D-isomer-specific 2-hydroxyacid-related dehydrogenase; Region: HPPR; cd12156
633149006377	putative ligand binding site [chemical binding]; other site
633149006378	NAD binding site [chemical binding]; other site
633149006379	catalytic site [active]
633149006380	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
633149006381	dimerization interface [polypeptide binding]; other site
633149006382	putative DNA binding site [nucleotide binding]; other site
633149006383	putative Zn2+ binding site [ion binding]; other site
633149006384	Methyltransferase domain; Region: Methyltransf_31; pfam13847
633149006385	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
633149006386	S-adenosylmethionine binding site [chemical binding]; other site
633149006387	Methylenetetrahydrofolate reductase (MTHFR). 5,10-Methylenetetrahydrofolate is reduced to 5-methyltetrahydrofolate by methylenetetrahydrofolate reductase, a cytoplasmic, NAD(P)-dependent enzyme. 5-methyltetrahydrofolate is utilized by methionine synthase...; Region: MTHFR; cd00537
633149006388	FAD binding site [chemical binding]; other site
633149006389	Methionine synthase I (cobalamin-dependent), methyltransferase domain [Amino acid transport and metabolism]; Region: MetH; COG0646
633149006390	Homocysteine S-methyltransferase; Region: S-methyl_trans; pfam02574
633149006391	Methionine synthase I, cobalamin-binding domain [Amino acid transport and metabolism]; Region: MetH; COG1410
633149006392	MeTr subgroup of pterin binding enzymes. This family includes cobalamin-dependent methyltransferases such as methyltetrahydrofolate, corrinoid iron-sulfur protein methyltransferase (MeTr) and methionine synthase (MetH).  Cobalamin-dependent...; Region: MeTr; cd00740
633149006393	substrate binding pocket [chemical binding]; other site
633149006394	B12 binding domain of methionine synthase. This domain binds methylcobalamin, which it uses as an intermediate methyl carrier from methyltetrahydrofolate (CH3H4folate) to homocysteine (Hcy); Region: methionine_synthase_B12_BD; cd02069
633149006395	B12 binding site [chemical binding]; other site
633149006396	cobalt ligand [ion binding]; other site
633149006397	Vitamin B12 dependent methionine synthase, activation domain; Region: Met_synt_B12; pfam02965
633149006398	Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620
633149006399	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244
633149006400	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244
633149006401	Putative phosphatase (DUF442); Region: DUF442; cl17385
633149006402	Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849
633149006403	Protein of unknown function (DUF1499); Region: DUF1499; cl01841
633149006404	putative acyl-CoA synthetase; Provisional; Region: PRK06018
633149006405	Fatty acyl-CoA synthetases similar to LC-FACS from Thermus thermophiles; Region: ttLC_FACS_AlkK_like; cd12119
633149006406	dimer interface [polypeptide binding]; other site
633149006407	acyl-activating enzyme (AAE) consensus motif; other site
633149006408	putative active site [active]
633149006409	AMP binding site [chemical binding]; other site
633149006410	putative CoA binding site [chemical binding]; other site
633149006411	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
633149006412	Small Multidrug Resistance protein; Region: Multi_Drug_Res; cl00910
633149006413	Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates...; Region: NK; cl17190
633149006414	Uridine kinase [Nucleotide transport and metabolism]; Region: Udk; COG0572
633149006415	active site
633149006416	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
633149006417	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
633149006418	AefR-like transcriptional repressor, C-terminal region; Region: TetR_C_7; pfam14246
633149006419	pyridoxamine 5'-phosphate oxidase; Provisional; Region: PRK05679
633149006420	Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_oxidase; pfam01243
633149006421	Pyridoxine 5'-phosphate oxidase C-terminal dimerisation region; Region: PNPOx_C; pfam10590
633149006422	C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747
633149006423	Chorismate synthase [Amino acid transport and metabolism]; Region: AroC; COG0082
633149006424	Chorismase synthase, the enzyme catalyzing the final step of the shikimate pathway; Region: Chorismate_synthase; cd07304
633149006425	Tetramer interface [polypeptide binding]; other site
633149006426	active site
633149006427	FMN-binding site [chemical binding]; other site
633149006428	Organic radical activating enzymes [Posttranslational modification, protein turnover, chaperones]; Region: NrdG; COG0602
633149006429	putative 7-cyano-7-deazaguanosine (preQ0) biosynthesis protein QueE; Region: rSAM_QueE_Ecoli; TIGR04322
633149006430	ExsB is a transcription regulator related protein. It is a subfamily of a Adenosine nucleotide binding superfamily of proteins. This protein family is represented by a single member in nearly every completed large (> 1000 genes) prokaryotic genome. In...; Region: ExsB; cd01995
633149006431	Ligand Binding Site [chemical binding]; other site
633149006432	The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354
633149006433	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
633149006434	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
633149006435	dimer interface [polypeptide binding]; other site
633149006436	phosphorylation site [posttranslational modification]
633149006437	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
633149006438	ATP binding site [chemical binding]; other site
633149006439	Mg2+ binding site [ion binding]; other site
633149006440	G-X-G motif; other site
633149006441	Response regulator receiver domain; Region: Response_reg; pfam00072
633149006442	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
633149006443	active site
633149006444	phosphorylation site [posttranslational modification]
633149006445	intermolecular recognition site; other site
633149006446	dimerization interface [polypeptide binding]; other site
633149006447	putative exonuclease, DNA ligase-associated; Region: Xnuc_lig_assoc; TIGR04122
633149006448	Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849
633149006449	PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria.  Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443
633149006450	CoenzymeA binding site [chemical binding]; other site
633149006451	subunit interaction site [polypeptide binding]; other site
633149006452	PHB binding site; other site
633149006453	PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria.  Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443
633149006454	Thioesterase-like superfamily; Region: 4HBT_3; pfam13622
633149006455	CoenzymeA binding site [chemical binding]; other site
633149006456	subunit interaction site [polypeptide binding]; other site
633149006457	PHB binding site; other site
633149006458	Predicted transcriptional regulator [Transcription]; Region: COG2932
633149006459	Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529
633149006460	Catalytic site [active]
633149006461	Bacterial SH3 domain; Region: SH3_3; pfam08239
633149006462	lysyl-tRNA synthetase; Reviewed; Region: lysK; PRK00750
633149006463	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
633149006464	active site
633149006465	nucleotide binding site [chemical binding]; other site
633149006466	HIGH motif; other site
633149006467	KMSKS motif; other site
633149006468	Putative amidoligase enzyme; Region: Amidoligase_2; pfam12224
633149006469	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
633149006470	dimer interface [polypeptide binding]; other site
633149006471	phosphorylation site [posttranslational modification]
633149006472	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
633149006473	Response regulator receiver domain; Region: Response_reg; pfam00072
633149006474	active site
633149006475	phosphorylation site [posttranslational modification]
633149006476	intermolecular recognition site; other site
633149006477	dimerization interface [polypeptide binding]; other site
633149006478	S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Provisional; Region: queA; PRK00147
633149006479	S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Region: queA; TIGR00113
633149006480	DNA repair protein RadA; Provisional; Region: PRK11823
633149006481	RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233
633149006482	Walker A motif; other site
633149006483	ATP binding site [chemical binding]; other site
633149006484	Walker B motif; other site
633149006485	Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541
633149006486	Colicin V production protein; Region: Colicin_V; pfam02674
633149006487	amidophosphoribosyltransferase; Provisional; Region: PRK09123
633149006488	Glutamine amidotransferases class-II (GN-AT)_GPAT- type. This domain is found at the N-terminus of  glutamine phosphoribosylpyrophosphate (Prpp) amidotransferase (GPATase) . The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the...; Region: GPATase_N; cd00715
633149006489	active site
633149006490	tetramer interface [polypeptide binding]; other site
633149006491	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
633149006492	active site
633149006493	N-terminal domain of Streptomyces griseus SgaA (suppression of growth disturbance caused by A-factor at a high concentration under high osmolality during early growth phase), and similar domains; Region: SgaA_N_like; cd07247
633149006494	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
633149006495	putative oxoacyl-(acyl carrier protein) reductase; Provisional; Region: PRK08945
633149006496	NAD(P) binding site [chemical binding]; other site
633149006497	active site
633149006498	Predicted dehydrogenase [General function prediction only]; Region: COG0579
633149006499	hydroxyglutarate oxidase; Provisional; Region: PRK11728
633149006500	Coenzyme Q-binding protein COQ10p and similar proteins; Region: COQ10p_like; cd07813
633149006501	putative coenzyme Q binding site [chemical binding]; other site
633149006502	lipoyl synthase; Provisional; Region: PRK05481
633149006503	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
633149006504	FeS/SAM binding site; other site
633149006505	Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318
633149006506	C-terminal domain of the acyl-acyl carrier protein synthetase (also called 2-acylglycerophosphoethanolamine acyltransferase, Aas); Region: AAS_C; cd05909
633149006507	acyl-activating enzyme (AAE) consensus motif; other site
633149006508	putative AMP binding site [chemical binding]; other site
633149006509	The Class III extradiol dioxygenase, 4,5-DOPA Dioxygenase, catalyzes the incorporation of both atoms of molecular oxygen into 4,5-dihydroxy-phenylalanine; Region: 45_DOPA_Dioxygenase; cd07363
633149006510	Catalytic LigB subunit of aromatic ring-opening dioxygenase; Region: LigB; pfam02900
633149006511	putative active site [active]
633149006512	metal binding site [ion binding]; metal-binding site
633149006513	NAD(P)H:quinone oxidoreductase; Provisional; Region: PRK03767
633149006514	NADPH-dependent FMN reductase; Region: FMN_red; pfam03358
633149006515	D-alanyl-D-alanine carboxypeptidase; Region: VanY; pfam02557
633149006516	Na+/melibiose symporter and related transporters [Carbohydrate transport and metabolism]; Region: MelB; COG2211
633149006517	melibiose:sodium symporter; Provisional; Region: PRK10429; cl15392
633149006518	nucleoside triphosphate pyrophosphohydrolase; Reviewed; Region: mazG; PRK09562
633149006519	Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) N-terminal tandem-domain of MazG proteins from Escherichia coli and bacterial homologs; Region: NTP-PPase_MazG_Nterm; cd11528
633149006520	homodimer interface [polypeptide binding]; other site
633149006521	metal binding site [ion binding]; metal-binding site
633149006522	Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) C-terminal tandem-domain of MazG proteins from Escherichia coli and bacterial homologs' Region: NTP-PPase_MazG_Cterm; cd11529
633149006523	homodimer interface [polypeptide binding]; other site
633149006524	active site
633149006525	putative chemical substrate binding site [chemical binding]; other site
633149006526	metal binding site [ion binding]; metal-binding site
633149006527	Domain of Unknown Function (DUF1543); Region: DUF1543; pfam07566
633149006528	hypothetical protein; Provisional; Region: PRK09897
633149006529	FAD-NAD(P)-binding; Region: NAD_binding_9; pfam13454
633149006530	response regulator PleD; Reviewed; Region: pleD; PRK09581
633149006531	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
633149006532	active site
633149006533	phosphorylation site [posttranslational modification]
633149006534	intermolecular recognition site; other site
633149006535	dimerization interface [polypeptide binding]; other site
633149006536	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
633149006537	active site
633149006538	phosphorylation site [posttranslational modification]
633149006539	intermolecular recognition site; other site
633149006540	dimerization interface [polypeptide binding]; other site
633149006541	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
633149006542	metal binding site [ion binding]; metal-binding site
633149006543	active site
633149006544	I-site; other site
633149006545	FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784
633149006546	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
633149006547	active site
633149006548	phosphorylation site [posttranslational modification]
633149006549	intermolecular recognition site; other site
633149006550	dimerization interface [polypeptide binding]; other site
633149006551	DNA polymerase IV; Provisional; Region: PRK02794
633149006552	DNA Polymerase IV/Kappa; Region: PolY_Pol_IV_kappa; cd03586
633149006553	active site
633149006554	DNA binding site [nucleotide binding]
633149006555	Putative catalytic NodB homology domain of gellan lyase and similar proteins; Region: CE4_GLA_like_6s; cd10967
633149006556	Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726
633149006557	putative active site [active]
633149006558	putative metal binding site [ion binding]; other site
633149006559	This group of proteins belong to a large family of YjgF/YER057c/UK114-like proteins present in bacteria, archaea, and eukaryotes with no definitive function.  The conserved domain is similar in structure to chorismate mutase but there is no sequence...; Region: YjgF_YER057c_UK114_like_1; cd02199
633149006560	homotrimer interaction site [polypeptide binding]; other site
633149006561	putative active site [active]
633149006562	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3146
633149006563	Protein of unknown function, DUF482; Region: DUF482; pfam04339
633149006564	Domain of unknown function (DUF4287); Region: DUF4287; pfam14117
633149006565	DNA mismatch repair protein; Reviewed; Region: mutL; PRK00095
633149006566	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
633149006567	ATP binding site [chemical binding]; other site
633149006568	Mg2+ binding site [ion binding]; other site
633149006569	G-X-G motif; other site
633149006570	MutL_Trans: transducer domain, having a ribosomal S5 domain 2-like fold, conserved in the C-terminal domain of DNA mismatch repair (MutL/MLH1/PMS2) family. This transducer domain is homologous to the second domain of the DNA gyrase B subunit, which is...; Region: MutL_Trans; cd00782
633149006571	ATP binding site [chemical binding]; other site
633149006572	MutL C terminal dimerisation domain; Region: MutL_C; pfam08676
633149006573	Low molecular weight phosphatase family; Region: LMWPc; cd00115
633149006574	Low molecular weight phosphotyrosine protein phosphatase; Region: LMWPc; pfam01451
633149006575	active site
633149006576	Conserved hypothetical protein 95; Region: Cons_hypoth95; pfam03602
633149006577	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
633149006578	S-adenosylmethionine binding site [chemical binding]; other site
633149006579	CAAX protease self-immunity; Region: Abi; pfam02517
633149006580	16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187
633149006581	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
633149006582	RNA binding surface [nucleotide binding]; other site
633149006583	Pseudouridine synthase, Escherichia coli RluB like; Region: PseudoU_synth_RluB; cd02556
633149006584	probable active site [active]
633149006585	Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285
633149006586	nucleoside/Zn binding site; other site
633149006587	dimer interface [polypeptide binding]; other site
633149006588	catalytic motif [active]
633149006589	Membrane-bound lysozyme-inhibitor of c-type lysozyme; Region: MliC; cl01604
633149006590	Dehydroquinate synthase (DHQS) catalyzes the conversion of DAHP to DHQ in shikimate pathway for aromatic compounds synthesis; Region: DHQS; cd08195
633149006591	active site
633149006592	dimer interface [polypeptide binding]; other site
633149006593	metal binding site [ion binding]; metal-binding site
633149006594	shikimate kinase; Provisional; Region: PRK13946
633149006595	Shikimate kinase (SK) is the fifth enzyme in the shikimate pathway, a seven-step biosynthetic pathway which converts erythrose-4-phosphate to chorismic acid, found in bacteria, fungi and plants. Chorismic acid is a important intermediate in the synthesis...; Region: SK; cd00464
633149006596	ADP binding site [chemical binding]; other site
633149006597	magnesium binding site [ion binding]; other site
633149006598	putative shikimate binding site; other site
633149006599	Site-specific recombinase XerD [DNA replication, recombination, and repair]; Region: XerD; COG4974
633149006600	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
633149006601	active site
633149006602	DNA binding site [nucleotide binding]
633149006603	Int/Topo IB signature motif; other site
633149006604	Domain of unknown function (DUF1902); Region: DUF1902; pfam08972
633149006605	acetyl-CoA carboxylase carboxyltransferase subunit alpha; Validated; Region: PRK05724
633149006606	acetyl-CoA carboxylase carboxyltransferase alpha subunit; Provisional; Region: accA; CHL00198
633149006607	ABC-type transport system involved in Fe-S cluster assembly, permease and ATPase components [Posttranslational modification, protein turnover, chaperones]; Region: ATM1; COG5265
633149006608	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
633149006609	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
633149006610	Walker A/P-loop; other site
633149006611	ATP binding site [chemical binding]; other site
633149006612	Q-loop/lid; other site
633149006613	ABC transporter signature motif; other site
633149006614	Walker B; other site
633149006615	D-loop; other site
633149006616	H-loop/switch region; other site
633149006617	lipoate-protein ligase B; Provisional; Region: PRK14341
633149006618	hypothetical protein; Validated; Region: PRK06033
633149006619	Mg/Co/Ni transporter MgtE (contains CBS domain) [Inorganic ion transport and metabolism]; Region: MgtE; COG2239
633149006620	MgtE intracellular N domain; Region: MgtE_N; smart00924
633149006621	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domain in the magnesium transporter, MgtE.  MgtE and its homologs are found in eubacteria, archaebacteria, and eukaryota. Members of this family transport Mg2+ or other...; Region: CBS_pair_Mg_transporter; cd04606
633149006622	Divalent cation transporter; Region: MgtE; pfam01769
633149006623	lysozyme_like domain.  This contains several members including Soluble Lytic Transglycosylases (SLT), Goose Egg-White Lysozymes (GEWL), Hen Egg-White Lysozymes (HEWL), chitinases, bacteriophage lambda lysozymes, endolysins, autolysins, and chitosanases; Region: lysozyme_like; cl00222
633149006624	catalytic residue [active]
633149006625	isovaleryl-CoA dehydrogenase; Region: PLN02519
633149006626	Isovaleryl-CoA dehydrogenase; Region: IVD; cd01156
633149006627	substrate binding site [chemical binding]; other site
633149006628	FAD binding site [chemical binding]; other site
633149006629	catalytic base [active]
633149006630	Protein of unknwon function (DUF3008); Region: DUF3008; pfam11450
633149006631	Exopolysaccharide synthesis, ExoD; Region: ExoD; pfam06055
633149006632	Exopolysaccharide synthesis, ExoD; Region: ExoD; pfam06055
633149006633	flagellin; Provisional; Region: PRK12802
633149006634	Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669
633149006635	Bacterial flagellin C-terminal helical region; Region: Flagellin_C; pfam00700
633149006636	flagellar biosynthesis regulatory protein FlaF; Reviewed; Region: flaF; PRK12794
633149006637	flagellar biosynthesis repressor FlbT; Reviewed; Region: flbT; PRK00794
633149006638	Tetratricopeptide repeat; Region: TPR_16; pfam13432
633149006639	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
633149006640	TPR motif; other site
633149006641	binding surface
633149006642	Tetratricopeptide repeat; Region: TPR_16; pfam13432
633149006643	Tetratricopeptide repeat; Region: TPR_16; pfam13432
633149006644	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
633149006645	binding surface
633149006646	TPR motif; other site
633149006647	TPR repeat; Region: TPR_11; pfam13414
633149006648	ATPases associated with a variety of cellular activities; Region: AAA; smart00382
633149006649	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
633149006650	Walker A motif; other site
633149006651	ATP binding site [chemical binding]; other site
633149006652	Walker B motif; other site
633149006653	arginine finger; other site
633149006654	RTX toxins and related Ca2+-binding proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2931
633149006655	Predicted hydrolases of HD superfamily [General function prediction only]; Region: COG1896
633149006656	Uncharacterized conserved protein [General function prediction only]; Region: COG4111
633149006657	4-hydroxybenzoate 3-monooxygenase; Validated; Region: PRK08243
633149006658	ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314
633149006659	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
633149006660	D-galactonate transporter; Region: 2A0114; TIGR00893
633149006661	putative substrate translocation pore; other site
633149006662	Transcriptional regulators [Transcription]; Region: MarR; COG1846
633149006663	MarR family; Region: MarR_2; pfam12802
633149006664	Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804
633149006665	CoA-transferase family III; Region: CoA_transf_3; pfam02515
633149006666	2-hydroxyglutaryl-CoA dehydratase, D-component; Region: HGD-D; pfam06050
633149006667	2-hydroxyglutaryl-CoA dehydratase, D-component; Region: HGD-D; pfam06050
633149006668	Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629
633149006669	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244
633149006670	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244
633149006671	putative hydrolase, CocE/NonD family; Region: /NonD; TIGR00976
633149006672	X-Pro dipeptidyl-peptidase C-terminal non-catalytic domain; Region: PepX_C; pfam08530
633149006673	Bacterial capsule synthesis protein PGA_cap; Region: PGA_cap; smart00854
633149006674	CapA and related proteins, metallophosphatase domain; Region: MPP_CapA; cd07381
633149006675	putative active site [active]
633149006676	putative metal binding site [ion binding]; other site
633149006677	Dipeptidyl aminopeptidases/acylaminoacyl-peptidases [Amino acid transport and metabolism]; Region: DAP2; COG1506
633149006678	bicyclomycin/multidrug efflux system; Provisional; Region: PRK11102
633149006679	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
633149006680	putative substrate translocation pore; other site
633149006681	acyl-CoA synthetase; Validated; Region: PRK09088
633149006682	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
633149006683	acyl-activating enzyme (AAE) consensus motif; other site
633149006684	AMP binding site [chemical binding]; other site
633149006685	active site
633149006686	CoA binding site [chemical binding]; other site
633149006687	p-hydroxycinnamoyl CoA hydratase/lyase; Validated; Region: PRK09120
633149006688	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
633149006689	substrate binding site [chemical binding]; other site
633149006690	oxyanion hole (OAH) forming residues; other site
633149006691	trimer interface [polypeptide binding]; other site
633149006692	Aldehyde dehydrogenase family; Region: Aldedh; pfam00171
633149006693	Salicylaldehyde dehydrogenase, DoxF-like; Region: ALDH_SaliADH; cd07105
633149006694	NAD(P) binding site [chemical binding]; other site
633149006695	catalytic residues [active]
633149006696	MarR family; Region: MarR_2; cl17246
633149006697	helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347
633149006698	Predicted Zn-dependent proteases and their inactivated homologs [General function prediction only]; Region: TldD; COG0312
633149006699	Predicted Zn-dependent proteases and their inactivated homologs [General function prediction only]; Region: TldD; COG0312
633149006700	Domain of unknown function (DUF4159); Region: DUF4159; pfam13709
633149006701	MoxR-like ATPases [General function prediction only]; Region: COG0714
633149006702	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
633149006703	Walker A motif; other site
633149006704	ATP binding site [chemical binding]; other site
633149006705	Walker B motif; other site
633149006706	arginine finger; other site
633149006707	Uncharacterized conserved protein (some members contain a von Willebrand factor type A (vWA) domain) [General function prediction only]; Region: COG1721
633149006708	Protein of unknown function DUF58; Region: DUF58; pfam01882
633149006709	von Willebrand factor type A domain; Region: VWA_2; pfam13519
633149006710	Amidase; Region: Amidase; cl11426
633149006711	Protein of unknown function (DUF4237); Region: DUF4237; pfam14021
633149006712	manganese transport regulator MntR; Provisional; Region: PRK11050
633149006713	Iron dependent repressor, N-terminal DNA binding domain; Region: Fe_dep_repress; pfam01325
633149006714	Iron dependent repressor, metal binding and dimerisation domain; Region: Fe_dep_repr_C; pfam02742
633149006715	type II secretion system protein D; Region: type_II_gspD; TIGR02517
633149006716	type II secretion system protein D; Region: type_II_gspD; TIGR02517
633149006717	Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958
633149006718	Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958
633149006719	Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958
633149006720	Bacterial type II and III secretion system protein; Region: Secretin; pfam00263
633149006721	Type IV pilus biogenesis; Region: Pilus_PilP; pfam11356
633149006722	type II secretion system protein I; Region: gspI; TIGR01707
633149006723	Type II secretion system (T2SS), protein I; Region: T2SI; pfam02501
633149006724	Type IV pilin N-term methylation site GFxxxE; Region: N_methyl_2; cl06830
633149006725	type II secretion system protein H; Region: typeII_sec_gspH; TIGR01708
633149006726	Type II secretion system (T2SS), protein G; Region: T2SG; pfam08334
633149006727	Type II secretion system (T2SS), protein L; Region: T2SL; pfam05134
633149006728	Type II secretion system (T2SS), protein M; Region: T2SM; pfam04612
633149006729	type II secretion system protein E; Region: type_II_gspE; TIGR02533
633149006730	PulE/GspE The type II secretory pathway is the main terminal branch of the general secretory pathway (GSP). It is responsible for the export the majority of Gram-negative bacterial exoenzymes and toxins. PulE is a cytoplasmic protein of the GSP, which...; Region: PulE-GspE; cd01129
633149006731	Walker A motif; other site
633149006732	ATP binding site [chemical binding]; other site
633149006733	Walker B motif; other site
633149006734	type II secretion system protein F; Region: GspF; TIGR02120
633149006735	Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482
633149006736	Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482
633149006737	Type II secretion system (T2SS), protein J; Region: T2SJ; pfam11612
633149006738	TonB-dependent receptor; Region: TonB-Xanth-Caul; TIGR01782
633149006739	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244
633149006740	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244
633149006741	Pectate lyase; Region: Pec_lyase_C; cl01593
633149006742	Uncharacterized conserved protein [Function unknown]; Region: COG4095
633149006743	Low affinity iron permease; Region: Iron_permease; pfam04120
633149006744	amidase; Provisional; Region: PRK08137
633149006745	Amidase; Region: Amidase; cl11426
633149006746	Dipeptidyl peptidase IV (DPP IV) N-terminal region; Region: DPPIV_N; pfam00930
633149006747	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
633149006748	Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326
633149006749	Flavodoxin reductases (ferredoxin-NADPH reductases) family 1 [Energy production and conversion]; Region: Hmp; COG1018
633149006750	Ferredoxin-NADP+ (oxido)reductase is an FAD-containing enzyme that catalyzes the reversible electron transfer between NADP(H) and electron carrier proteins such as ferredoxin and flavodoxin. Isoforms of these flavoproteins (i.e. having a non-covalently...; Region: FNR1; cd06195
633149006751	FAD binding pocket [chemical binding]; other site
633149006752	FAD binding motif [chemical binding]; other site
633149006753	phosphate binding motif [ion binding]; other site
633149006754	beta-alpha-beta structure motif; other site
633149006755	NAD binding pocket [chemical binding]; other site
633149006756	Chorismate mutase type II; Region: CM_2; smart00830
633149006757	amino acid transporter; Region: 2A0306; TIGR00909
633149006758	Undecaprenyl-phosphate glucose phosphotransferase; Region: WcaJ_sugtrans; TIGR03023
633149006759	Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160
633149006760	Bacterial sugar transferase; Region: Bac_transf; pfam02397
633149006761	Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244
633149006762	Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326
633149006763	Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326
633149006764	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
633149006765	active site
633149006766	Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463
633149006767	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761
633149006768	active site
633149006769	Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365
633149006770	Protease II [Amino acid transport and metabolism]; Region: PtrB; COG1770
633149006771	Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326
633149006772	Sortase and related acyltransferases [Cell envelope biogenesis, outer membrane]; Region: COG1247
633149006773	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
633149006774	Coenzyme A binding pocket [chemical binding]; other site
633149006775	response regulator; Provisional; Region: PRK13435
633149006776	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
633149006777	active site
633149006778	phosphorylation site [posttranslational modification]
633149006779	intermolecular recognition site; other site
633149006780	dimerization interface [polypeptide binding]; other site
633149006781	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920
633149006782	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
633149006783	ATP binding site [chemical binding]; other site
633149006784	Mg2+ binding site [ion binding]; other site
633149006785	G-X-G motif; other site
633149006786	ketol-acid reductoisomerase; Provisional; Region: PRK05479
633149006787	Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvN; pfam07991
633149006788	Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvC; pfam01450
633149006789	Bacterial protein of unknown function (DUF924); Region: DUF924; pfam06041
633149006790	thymidylate synthase; Reviewed; Region: thyA; PRK01827
633149006791	Thymidylate synthase and pyrimidine hydroxymethylase: Thymidylate synthase (TS) and deoxycytidylate hydroxymethylase (dCMP-HMase) are homologs that catalyze analogous alkylation of C5 of pyrimidine nucleotides. Both enzymes are involved in the...; Region: TS_Pyrimidine_HMase; cd00351
633149006792	dimerization interface [polypeptide binding]; other site
633149006793	active site
633149006794	Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in a group of uncharacterized proteins from bacteria; Region: NTP-PPase_u1; cd11538
633149006795	metal binding site [ion binding]; metal-binding site
633149006796	Dihydrofolate reductase [Coenzyme metabolism]; Region: FolA; COG0262
633149006797	Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5; Region: DHFR; cd00209
633149006798	folate binding site [chemical binding]; other site
633149006799	NADP+ binding site [chemical binding]; other site
633149006800	Putative heavy-metal-binding; Region: YbjQ_1; cl00426
633149006801	S23 ribosomal protein; Region: Ribosomal_S23p; pfam05635
633149006802	four helix bundle protein; Region: TIGR02436
633149006803	Sterol desaturase [Lipid metabolism]; Region: ERG3; COG3000
633149006804	Fatty acid hydroxylase superfamily; Region: FA_hydroxylase; pfam04116
633149006805	NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902
633149006806	Old yellow enzyme (OYE)-related FMN binding domain, group 5.  Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a reducing agent with oxygens, quinones, and alpha,beta-unsaturated aldehydes and ketones, and can act as...; Region: OYE_like_5_FMN; cd04747
633149006807	putative active site [active]
633149006808	putative FMN binding site [chemical binding]; other site
633149006809	putative substrate binding site [chemical binding]; other site
633149006810	putative catalytic residue [active]
633149006811	Domain of unknown function DUF59; Region: DUF59; pfam01883
633149006812	ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Mrp; COG0489
633149006813	MRP (Multiple Resistance and pH adaptation) is a homologue of the Fer4_NifH superfamily. Like the other members of the superfamily, MRP contains a ATP-binding domain at the N-termini. It is found in bacteria as a membrane-spanning protein and functions...; Region: MRP-like; cd02037
633149006814	tRNA delta(2)-isopentenylpyrophosphate transferase; Reviewed; Region: miaA; PRK00091
633149006815	tRNA delta(2)-isopentenylpyrophosphate transferase [Translation, ribosomal structure and biogenesis]; Region: MiaA; COG0324
633149006816	Lipid A disaccharide synthetase [Cell envelope biogenesis, outer membrane]; Region: LpxB; COG0763
633149006817	ipid-A-disaccharide synthase; Provisional; Region: PRK14089
633149006818	Protein of unknown function (DUF1009); Region: DUF1009; cl09182
633149006819	UDP-N-acetylglucosamine acyltransferase; Provisional; Region: PRK05289
633149006820	UDP-N-acetylglucosamine O-acyltransferase (UDP-GlcNAc acyltransferase): Proteins in this family catalyze the transfer of (R)-3-hydroxymyristic acid from its acyl carrier protein thioester to UDP-GlcNAc. It is the first enzyme in the lipid A biosynthetic...; Region: LbH_UDP-GlcNAc_AT; cd03351
633149006821	active site
633149006822	FabZ is a 17kD beta-hydroxyacyl-acyl carrier protein (ACP) dehydratase that primarily catalyzes the dehydration of beta-hydroxyacyl-ACP to trans-2-acyl-ACP, the third step in the elongation phase of the bacterial/ plastid, type II, fatty-acid...; Region: FabZ; cd01288
633149006823	UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase; Provisional; Region: lpxD; PRK00892
633149006824	UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase, LpxD; Region: LpxD; pfam04613
633149006825	UDP-3-O-acyl-glucosamine N-acyltransferase (LpxD): The enzyme catalyzes the transfer of 3-hydroxymyristic acid or 3-hydroxy-arachidic acid, depending on the organism, from the acyl carrier protein (ACP) to UDP-3-O-acyl-glucosamine to produce UDP-2; Region: LbH_LpxD; cd03352
633149006826	trimer interface [polypeptide binding]; other site
633149006827	active site
633149006828	UDP-GlcNAc binding site [chemical binding]; other site
633149006829	lipid binding site [chemical binding]; lipid-binding site
633149006830	Outer membrane protein (OmpH-like); Region: OmpH; pfam03938
633149006831	outer membrane protein assembly complex, YaeT protein; Region: OM_YaeT; TIGR03303
633149006832	Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244
633149006833	Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244
633149006834	Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244
633149006835	Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244
633149006836	Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244
633149006837	Surface antigen; Region: Bac_surface_Ag; pfam01103
633149006838	Predicted membrane-associated Zn-dependent proteases 1 [Cell envelope biogenesis, outer membrane]; Region: COG0750
633149006839	RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163
633149006840	active site
633149006841	PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989
633149006842	protein binding site [polypeptide binding]; other site
633149006843	Site-2 protease (S2P) class of zinc metalloproteases (MEROPS family M50) cleaves transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of this family use proteolytic...; Region: S2P-M50; cl10020
633149006844	putative substrate binding region [chemical binding]; other site
633149006845	1-deoxy-D-xylulose 5-phosphate reductoisomerase; Region: DXP_reductoisom; pfam02670
633149006846	1-deoxy-D-xylulose 5-phosphate reductoisomerase; Provisional; Region: PRK05447
633149006847	1-deoxy-D-xylulose 5-phosphate reductoisomerase C-terminal; Region: DXP_redisom_C; pfam08436
633149006848	DXP reductoisomerase C-terminal domain; Region: DXPR_C; pfam13288
633149006849	CDP-diglyceride synthetase [Lipid metabolism]; Region: CdsA; COG0575
633149006850	Cytidylyltransferase family; Region: CTP_transf_1; pfam01148
633149006851	Cis (Z)-Isoprenyl Diphosphate Synthases (cis-IPPS); homodimers which catalyze the successive 1'-4 condensation of the isopentenyl diphosphate (IPP) molecule to trans,trans-farnesyl diphosphate (FPP) or to cis,trans-FPP to form long-chain polyprenyl...; Region: CIS_IPPS; cl00230
633149006852	Putative undecaprenyl diphosphate synthase; Region: Prenyltransf; pfam01255
633149006853	catalytic residue [active]
633149006854	putative FPP diphosphate  binding site; other site
633149006855	putative FPP binding hydrophobic cleft; other site
633149006856	dimer interface [polypeptide binding]; other site
633149006857	putative IPP diphosphate binding site; other site
633149006858	ribosome recycling factor; Reviewed; Region: frr; PRK00083
633149006859	Ribosome recycling factor (RRF). Ribosome recycling factor dissociates the posttermination complex, composed of the ribosome, deacylated tRNA, and mRNA, after termination of translation.  Thus ribosomes are "recycled" and ready for another...; Region: RRF; cd00520
633149006860	hinge region; other site
633149006861	UMP kinase (UMPK)-Ec, the microbial/chloroplast uridine monophosphate kinase (uridylate kinase) enzyme that catalyzes UMP phosphorylation and plays a key role in pyrimidine nucleotide biosynthesis; regulation of this process is via feed-back control and...; Region: AAK_UMPK-PyrH-Ec; cd04254
633149006862	putative nucleotide binding site [chemical binding]; other site
633149006863	uridine monophosphate binding site [chemical binding]; other site
633149006864	homohexameric interface [polypeptide binding]; other site
633149006865	Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876
633149006866	Predicted aminopeptidases [General function prediction only]; Region: Iap; COG2234
633149006867	M28 Zn-Peptidases; Region: M28_like_4; cd08015
633149006868	Peptidase family M28; Region: Peptidase_M28; pfam04389
633149006869	metal binding site [ion binding]; metal-binding site
633149006870	elongation factor Ts; Provisional; Region: tsf; PRK09377
633149006871	UBA/TS-N domain; Region: UBA; pfam00627
633149006872	Elongation factor TS; Region: EF_TS; pfam00889
633149006873	Elongation factor TS; Region: EF_TS; pfam00889
633149006874	Ribosomal protein S2 (RPS2), involved in formation of the translation initiation complex, where it might contact the messenger RNA and several components of the ribosome. It has been shown that in Escherichia coli RPS2 is essential for the binding of...; Region: RPS2; cd01425
633149006875	rRNA interaction site [nucleotide binding]; other site
633149006876	S8 interaction site; other site
633149006877	putative laminin-1 binding site; other site
633149006878	Putative hydrophobic ligand-binding SRPBCC domain of an uncharacterized subgroup of CalC- and Aha1-like proteins; Region: SRPBCC_CalC_Aha1-like_9; cd07826
633149006879	putative hydrophobic ligand binding site [chemical binding]; other site
633149006880	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
633149006881	dimerization interface [polypeptide binding]; other site
633149006882	putative DNA binding site [nucleotide binding]; other site
633149006883	putative Zn2+ binding site [ion binding]; other site
633149006884	Domain of unknown function (DUF4142); Region: DUF4142; pfam13628
633149006885	D-Ala-D-Ala carboxypeptidase 3 (S13) family; Region: Peptidase_S13; cl17429
633149006886	DNA polymerase III subunit alpha; Validated; Region: dnaE; PRK05673
633149006887	Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III DnaE1; Region: PHP_PolIIIA_DnaE1; cd07433
633149006888	putative active site [active]
633149006889	putative PHP Thumb interface [polypeptide binding]; other site
633149006890	DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485
633149006891	generic binding surface I; other site
633149006892	generic binding surface II; other site
633149006893	Guanosine polyphosphate pyrophosphohydrolases/synthetases [Signal transduction mechanisms / Transcription]; Region: SpoT; COG0317
633149006894	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
633149006895	Zn2+ binding site [ion binding]; other site
633149006896	Mg2+ binding site [ion binding]; other site
633149006897	Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399
633149006898	synthetase active site [active]
633149006899	NTP binding site [chemical binding]; other site
633149006900	metal binding site [ion binding]; metal-binding site
633149006901	TGS_RelA_SpoT: The RelA (SpoT) protein, also referred to as ppGpp hydrolase/synthetase, is a ribosome-associated protein that is activated during amino acid starvation and thought to mediate the stringent response. RelA contains a TGS domain, named after...; Region: TGS_RelA_SpoT; cd01668
633149006902	ACT  domain found C-terminal of the RelA/SpoT domains; Region: ACT_RelA-SpoT; cd04876
633149006903	DNA-directed RNA polymerase subunit omega; Reviewed; Region: rpoZ; PRK00392
633149006904	7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase (HPPK). Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and amino acids as well as formyl-tRNA. Mammalian cells are able to utilize pre-formed folates after...; Region: HPPK; cd00483
633149006905	catalytic center binding site [active]
633149006906	ATP binding site [chemical binding]; other site
633149006907	Family-5 Uracil-DNA glycosylases (UDG), found in thermophilic organisms; Region: UDG_F5_TTUDGB_like; cd10031
633149006908	Fe-S cluster binding site [ion binding]; other site
633149006909	DNA binding site [nucleotide binding]
633149006910	active site
633149006911	Small protein B (SmpB) is a component of the trans-translation system in prokaryotes for releasing stalled ribosome from damaged messenger RNAs; Region: SmpB; cd09294
633149006912	SmpB-tmRNA interface; other site
633149006913	Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329
633149006914	Dihydrodipicolinate synthase (DHDPS); Region: DHDPS; cd00950
633149006915	dimer interface [polypeptide binding]; other site
633149006916	active site
633149006917	catalytic residue [active]
633149006918	Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741
633149006919	Lytic Transglycosylase (LT)  and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL).  LTs...; Region: LT_GEWL; cd00254
633149006920	N-acetyl-D-glucosamine binding site [chemical binding]; other site
633149006921	catalytic residue [active]
633149006922	ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120
633149006923	ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214
633149006924	Walker A/P-loop; other site
633149006925	ATP binding site [chemical binding]; other site
633149006926	Q-loop/lid; other site
633149006927	ABC transporter signature motif; other site
633149006928	Walker B; other site
633149006929	D-loop; other site
633149006930	H-loop/switch region; other site
633149006931	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550
633149006932	dimer interface [polypeptide binding]; other site
633149006933	putative PBP binding regions; other site
633149006934	ABC-ATPase subunit  interface; other site
633149006935	ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614
633149006936	Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+.  Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262
633149006937	intersubunit interface [polypeptide binding]; other site
633149006938	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
633149006939	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
633149006940	WHG domain; Region: WHG; pfam13305
633149006941	CESA_like_2 is a member of the cellulose synthase superfamily; Region: CESA_like_2; cd06427
633149006942	Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641
633149006943	DXD motif; other site
633149006944	Predicted SAM-dependent methyltransferases [General function prediction only]; Region: COG1092
633149006945	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
633149006946	S-adenosylmethionine binding site [chemical binding]; other site
633149006947	rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566
633149006948	RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; smart00967
633149006949	SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588
633149006950	metabolite-proton symporter; Region: 2A0106; TIGR00883
633149006951	Uncharacterized conserved protein [Function unknown]; Region: COG3791
633149006952	ATP-dependent helicase HrpB; Region: DEAH_box_HrpB; TIGR01970
633149006953	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
633149006954	putative Mg++ binding site [ion binding]; other site
633149006955	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
633149006956	nucleotide binding region [chemical binding]; other site
633149006957	ATP-binding site [chemical binding]; other site
633149006958	Helicase associated domain (HA2); Region: HA2; pfam04408
633149006959	ATP-dependent helicase C-terminal; Region: HrpB_C; pfam08482
633149006960	amino acid transporter; Region: 2A0306; TIGR00909
633149006961	Flagellar motor protein [Cell motility and secretion]; Region: MotB; COG1360
633149006962	Membrane MotB of proton-channel complex MotA/MotB; Region: MotB_plug; pfam13677
633149006963	Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185
633149006964	ligand binding site [chemical binding]; other site
633149006965	arginyl-tRNA-protein transferase; Provisional; Region: PRK01305
633149006966	Arginine-tRNA-protein transferase, N terminus; Region: ATE_N; pfam04376
633149006967	Arginine-tRNA-protein transferase, C terminus; Region: ATE_C; pfam04377
633149006968	enolase; Provisional; Region: eno; PRK00077
633149006969	Enolase: Enolases are homodimeric enzymes that catalyse the reversible dehydration of 2-phospho-D-glycerate to phosphoenolpyruvate as part of the glycolytic and gluconeogenesis pathways. The reaction is facilitated by the presence of metal ions; Region: enolase; cd03313
633149006970	dimer interface [polypeptide binding]; other site
633149006971	metal binding site [ion binding]; metal-binding site
633149006972	substrate binding pocket [chemical binding]; other site
633149006973	Ribosomal protein L32 [Translation, ribosomal structure and biogenesis]; Region: RpmF; COG0333
633149006974	GTP-binding protein Der; Reviewed; Region: PRK00093
633149006975	EngA1 GTPase contains the first domain of EngA; Region: EngA1; cd01894
633149006976	G1 box; other site
633149006977	GTP/Mg2+ binding site [chemical binding]; other site
633149006978	Switch I region; other site
633149006979	G2 box; other site
633149006980	Switch II region; other site
633149006981	G3 box; other site
633149006982	G4 box; other site
633149006983	G5 box; other site
633149006984	EngA2 GTPase contains the second domain of EngA; Region: EngA2; cd01895
633149006985	G1 box; other site
633149006986	GTP/Mg2+ binding site [chemical binding]; other site
633149006987	Switch I region; other site
633149006988	G2 box; other site
633149006989	G3 box; other site
633149006990	Switch II region; other site
633149006991	G4 box; other site
633149006992	G5 box; other site
633149006993	PQQ-dependent dehydrogenases and related proteins; Region: PQQ_DH_like; cl11493
633149006994	PQQ-like domain; Region: PQQ_2; pfam13360
633149006995	PQQ-dependent dehydrogenases and related proteins; Region: PQQ_DH_like; cl11493
633149006996	active site
633149006997	Trp docking motif [polypeptide binding]; other site
633149006998	PQQ-like domain; Region: PQQ_2; pfam13360
633149006999	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4649
633149007000	Ketopantoate hydroxymethyltransferase (KPHMT) is the first enzyme in the pantothenate biosynthesis pathway. Ketopantoate hydroxymethyltransferase (KPHMT) catalyzes the first committed step in the biosynthesis of pantothenate (vitamin B5), which is a...; Region: KPHMT-like; cd06557
633149007001	oligomerization interface [polypeptide binding]; other site
633149007002	active site
633149007003	metal binding site [ion binding]; metal-binding site
633149007004	RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937
633149007005	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
633149007006	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
633149007007	DNA binding residues [nucleotide binding]
633149007008	RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937
633149007009	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
633149007010	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
633149007011	DNA binding residues [nucleotide binding]
633149007012	Arsenate Reductase (ArsC) family, Yffb subfamily; Yffb is an uncharacterized bacterial protein encoded by the yffb gene, related to the thioredoxin-fold arsenic reductases, ArsC. The structure of Yffb and the conservation of the catalytic cysteine...; Region: ArsC_Yffb; cd03035
633149007013	ArsC family; Region: ArsC; pfam03960
633149007014	putative catalytic residues [active]
633149007015	Nitrogen regulatory protein PII [Amino acid transport and metabolism]; Region: GlnK; COG0347
633149007016	Nitrogen regulatory protein P-II; Region: P-II; smart00938
633149007017	glutamine synthetase; Provisional; Region: glnA; PRK09469
633149007018	Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951
633149007019	Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120
633149007020	methyltransferase, FkbM family; Region: fkbM_fam; TIGR01444
633149007021	Sec-independent protein secretion pathway component TatC [Intracellular trafficking and secretion]; Region: TatC; COG0805
633149007022	twin arginine-targeting protein translocase TatB; Region: tatB; TIGR01410
633149007023	mttA/Hcf106 family; Region: MttA_Hcf106; cl00788
633149007024	RNase HI family found mainly in prokaryotes; Region: RNase_HI_prokaryote_like; cd09278
633149007025	RNA/DNA hybrid binding site [nucleotide binding]; other site
633149007026	active site
633149007027	Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330
633149007028	Band_7_stomatin_like: A subgroup of the band 7 domain of flotillin (reggie) like proteins similar to stomatin and podicin (two lipid raft-associated integral membrane proteins). Individual proteins of this band 7 domain family may cluster to form...; Region: Band_7_stomatin_like; cd03403
633149007029	Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_15; cd04673
633149007030	nudix motif; other site
633149007031	FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277
633149007032	FAD binding domain; Region: FAD_binding_4; pfam01565
633149007033	hypothetical protein; Validated; Region: PRK02101
633149007034	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
633149007035	3-hydroxybutyrate dehydrogenase; Region: PHB_DH; TIGR01963
633149007036	NAD(P) binding site [chemical binding]; other site
633149007037	active site
633149007038	Predicted esterase of the alpha-beta hydrolase superfamily [General function prediction only]; Region: RssA; COG1752
633149007039	Hypothetical patatin similar to Z1214 protein of Escherichia coli; Region: Pat_hypo_Ecoli_Z1214_like; cd07209
633149007040	active site
633149007041	nucleophile elbow; other site
633149007042	This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632
633149007043	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
633149007044	active site
633149007045	Putative translation factor (SUA5) [Translation, ribosomal structure and biogenesis]; Region: SUA5; COG0009
633149007046	Putative GTP-binding controlling metal-binding; Region: SUA5; pfam03481
633149007047	YceI-like domain; Region: YceI; pfam04264
633149007048	Cytochrome B561 [Energy production and conversion]; Region: CybB; COG3038
633149007049	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
633149007050	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
633149007051	active site
633149007052	Acetyl-CoA dehydrogenase C-terminal like; Region: Acyl-CoA_dh_C; pfam12806
633149007053	ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Mrp; COG0489
633149007054	The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203
633149007055	Uncharacterized protein involved in exopolysaccharide biosynthesis [Cell envelope biogenesis, outer membrane]; Region: GumC; COG3206
633149007056	Chain length determinant protein; Region: Wzz; cl15801
633149007057	Polysaccharide biosynthesis/export protein; Region: Poly_export; pfam02563
633149007058	putative polysaccharide export protein, PEP-CTERM sytem-associated; Region: pepcterm_export; TIGR03027
633149007059	GST_N family, Ure2p-like subfamily; composed of the Saccharomyces cerevisiae Ure2p and related GSTs. Ure2p is a regulator for nitrogen catabolism in yeast. It represses the expression of several gene products involved in the use of poor nitrogen sources...; Region: GST_N_Ure2p_like; cd03048
633149007060	GSH-dependent disulfide bond oxidoreductase; Provisional; Region: PRK13972
633149007061	C-terminal domain interface [polypeptide binding]; other site
633149007062	GSH binding site (G-site) [chemical binding]; other site
633149007063	dimer interface [polypeptide binding]; other site
633149007064	C-terminal, alpha helical domain of the Glutathione S-transferase family; Region: GST_C_family; cl02776
633149007065	N-terminal domain interface [polypeptide binding]; other site
633149007066	dimer interface [polypeptide binding]; other site
633149007067	substrate binding pocket (H-site) [chemical binding]; other site
633149007068	Domain of unknown function (DUF3315); Region: DUF3315; cl02275
633149007069	Peptidase inhibitor I78 family; Region: Inhibitor_I78; pfam11720
633149007070	Peptidase inhibitor I78 family; Region: Inhibitor_I78; pfam11720
633149007071	DNA polymerase III chi subunit, HolC; Region: DNA_pol3_chi; pfam04364
633149007072	multifunctional aminopeptidase A; Provisional; Region: PRK00913
633149007073	Cytosol aminopeptidase family, N-terminal and catalytic domains.  Family M17 contains zinc- and manganese-dependent exopeptidases ( EC  3.4.11.1), including leucine aminopeptidase. They catalyze removal of amino acids from the N-terminus of a protein and...; Region: Peptidase_M17; cd00433
633149007074	interface (dimer of trimers) [polypeptide binding]; other site
633149007075	Substrate-binding/catalytic site; other site
633149007076	Zn-binding sites [ion binding]; other site
633149007077	Predicted permeases [General function prediction only]; Region: COG0795
633149007078	Predicted permease YjgP/YjgQ family; Region: YjgP_YjgQ; pfam03739
633149007079	Predicted permeases [General function prediction only]; Region: COG0795
633149007080	Predicted permease YjgP/YjgQ family; Region: YjgP_YjgQ; pfam03739
633149007081	Organic solvent tolerance protein OstA [Cell envelope biogenesis, outer membrane]; Region: Imp; COG1452
633149007082	Organic solvent tolerance protein; Region: OstA_C; pfam04453
633149007083	SurA N-terminal domain; Region: SurA_N; pfam09312
633149007084	PPIC-type PPIASE domain; Region: Rotamase; pfam00639
633149007085	PPIC-type PPIASE domain; Region: Rotamase_2; cl08278
633149007086	4-hydroxythreonine-4-phosphate dehydrogenase; Provisional; Region: pdxA; PRK05312
633149007087	4-hydroxythreonine-4-phosphate dehydrogenase; Validated; Region: pdxA; PRK03743
633149007088	16S ribosomal RNA methyltransferase KsgA/Dim1 family protein; Reviewed; Region: ksgA; PRK00274
633149007089	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
633149007090	S-adenosylmethionine binding site [chemical binding]; other site
633149007091	Dienelactone hydrolase and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG0412
633149007092	aspartate aminotransferase; Provisional; Region: PRK05764
633149007093	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
633149007094	pyridoxal 5'-phosphate binding site [chemical binding]; other site
633149007095	homodimer interface [polypeptide binding]; other site
633149007096	catalytic residue [active]
633149007097	formate--tetrahydrofolate ligase; Provisional; Region: PRK13505
633149007098	Formyltetrahydrofolate synthetase (FTHFS) catalyzes the ATP-dependent activation of formate ion via its addition to the N10 position of tetrahydrofolate. FTHFS is a highly expressed key enzyme in both the Wood-Ljungdahl pathway of autotrophic CO2...; Region: FTHFS; cd00477
633149007099	Potassium binding sites [ion binding]; other site
633149007100	Cesium cation binding sites [ion binding]; other site
633149007101	Guanylate kinase [Nucleotide transport and metabolism]; Region: Gmk; COG0194
633149007102	Guanosine monophosphate kinase (GMPK, EC 2.7.4.8), also known as guanylate kinase (GKase), catalyzes the reversible phosphoryl transfer from adenosine triphosphate (ATP) to guanosine monophosphate (GMP) to yield adenosine diphosphate (ADP) and guanosine...; Region: GMPK; cd00071
633149007103	catalytic site [active]
633149007104	G-X2-G-X-G-K; other site
633149007105	hypothetical protein; Provisional; Region: PRK11820
633149007106	YicC-like family, N-terminal region; Region: YicC_N; pfam03755
633149007107	Domain of unknown function (DUF1732); Region: DUF1732; pfam08340
633149007108	YceG-like family; Region: YceG; pfam02618
633149007109	proteins similar to Escherichia coli yceG; Region: yceG_like; cd08010
633149007110	dimerization interface [polypeptide binding]; other site
633149007111	3-oxoacyl-(acyl carrier protein) synthase II; Reviewed; Region: PRK07314
633149007112	Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834
633149007113	dimer interface [polypeptide binding]; other site
633149007114	active site
633149007115	acyl carrier protein; Provisional; Region: acpP; PRK00982
633149007116	3-oxoacyl-(acyl-carrier-protein) reductase; Region: 3oxo_ACP_reduc; TIGR01830
633149007117	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
633149007118	NAD(P) binding site [chemical binding]; other site
633149007119	active site
633149007120	(acyl-carrier-protein) S-malonyltransferase [Lipid metabolism]; Region: FabD; COG0331
633149007121	malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128
633149007122	30S ribosomal protein S6; Reviewed; Region: rpsF; PRK00453
633149007123	30S ribosomal protein S18; Reviewed; Region: rpsR; PRK00391
633149007124	50S ribosomal protein L9; Reviewed; Region: rplI; PRK00137
633149007125	Ribosomal protein L9, N-terminal domain; Region: Ribosomal_L9_N; pfam01281
633149007126	Ribosomal protein L9, C-terminal domain; Region: Ribosomal_L9_C; pfam03948
633149007127	Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629
633149007128	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
633149007129	N-terminal plug; other site
633149007130	ligand-binding site [chemical binding]; other site
633149007131	glutamyl-tRNA synthetase; Provisional; Region: PTZ00402
633149007132	replicative DNA helicase; Provisional; Region: PRK09165
633149007133	DnaB-like helicase N terminal domain; Region: DnaB; pfam00772
633149007134	DnaB helicase C terminal domain. The hexameric helicase DnaB unwinds the DNA duplex at the  chromosome replication fork. Although the mechanism by which DnaB both couples ATP hydrolysis to translocation along DNA and denatures the duplex is unknown, a...; Region: DnaB_C; cd00984
633149007135	Walker A motif; other site
633149007136	ATP binding site [chemical binding]; other site
633149007137	Walker B motif; other site
633149007138	DNA binding loops [nucleotide binding]
633149007139	RNA polymerase-binding protein DksA; Region: dksA; TIGR02420
633149007140	Class II flagellar assembly regulator; Region: FliX; cl11677
633149007141	flagellar basal body P-ring protein; Provisional; Region: flgI; PRK05303
633149007142	flagellar basal body P-ring protein; Reviewed; Region: flgI; cl14622
633149007143	Rod binding protein; Region: Rod-binding; cl01626
633149007144	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
633149007145	excinuclease ABC subunit A; Reviewed; Region: uvrA; PRK00349
633149007146	ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270
633149007147	ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270
633149007148	ATP-binding cassette domain II of the excision repair protein UvrA; Region: ABC_UvrA_II; cd03271
633149007149	CAAX protease self-immunity; Region: Abi; pfam02517
633149007150	Bovine immunodeficiency virus surface protein (SU); Region: BIV_Env; pfam05858
633149007151	tRNA (uracil-5-)-methyltransferase Gid; Reviewed; Region: PRK05335
633149007152	Glucose inhibited division protein A; Region: GIDA; pfam01134
633149007153	Isoprenoid Biosynthesis enzymes, Class 1; Region: Isoprenoid_Biosyn_C1; cl00210
633149007154	Protein of unknown function (DUF998); Region: DUF998; pfam06197
633149007155	Predicted membrane protein [Function unknown]; Region: COG3748
633149007156	preprotein translocase subunit SecF; Reviewed; Region: secF; PRK13022
633149007157	Protein export membrane protein; Region: SecD_SecF; pfam02355
633149007158	preprotein translocase subunit SecD; Reviewed; Region: secD; PRK05812
633149007159	SecD/SecF GG Motif; Region: Sec_GG; pfam07549
633149007160	protein-export membrane protein, SecD/SecF family; Region: 2A0604s01; TIGR00916
633149007161	Preprotein translocase subunit; Region: YajC; pfam02699
633149007162	Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739
633149007163	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
633149007164	Peptidase family M23; Region: Peptidase_M23; pfam01551
633149007165	Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cl02931
633149007166	ligand binding site [chemical binding]; other site
633149007167	protein-L-isoaspartate O-methyltransferase; Reviewed; Region: pcm; PRK00312
633149007168	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
633149007169	S-adenosylmethionine binding site [chemical binding]; other site
633149007170	5'(3')-nucleotidase/polyphosphatase; Provisional; Region: surE; PRK00346
633149007171	seryl-tRNA synthetase; Provisional; Region: PRK05431
633149007172	Seryl-tRNA synthetase N-terminal domain; Region: Seryl_tRNA_N; pfam02403
633149007173	Seryl-tRNA synthetase (SerRS) class II core catalytic domain. SerRS is responsible for the attachment of serine to the 3' OH group of ribose of the appropriate tRNA. This domain It is primarily responsible for ATP-dependent formation of the enzyme...; Region: SerRS_core; cd00770
633149007174	dimer interface [polypeptide binding]; other site
633149007175	active site
633149007176	motif 1; other site
633149007177	motif 2; other site
633149007178	motif 3; other site
633149007179	Predicted protease with the C-terminal PDZ domain [General function prediction only]; Region: COG3975
633149007180	M61 glycyl aminopeptidase; Region: Peptidase_M61; pfam05299
633149007181	PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989
633149007182	protein binding site [polypeptide binding]; other site
633149007183	PyridoxaL 5'-Phosphate Dependent Enzymes class IV (PLPDE_IV). This D-amino acid superfamily, one of five classes of PLPDE, consists of branched-chain amino acid aminotransferases (BCAT), D-amino acid transferases (DAAT), and...; Region: PLPDE_IV; cl00224
633149007184	Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115
633149007185	homodimer interface [polypeptide binding]; other site
633149007186	substrate-cofactor binding pocket; other site
633149007187	pyridoxal 5'-phosphate binding site [chemical binding]; other site
633149007188	catalytic residue [active]
633149007189	DNA gyrase subunit A; Validated; Region: PRK05560
633149007190	DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187
633149007191	CAP-like domain; other site
633149007192	active site
633149007193	primary dimer interface [polypeptide binding]; other site
633149007194	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
633149007195	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
633149007196	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
633149007197	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
633149007198	Copper/zinc superoxide dismutase (SOD). superoxide dismutases catalyse the conversion of superoxide radicals to molecular oxygen. Three evolutionarily distinct families of SODs are known, of which the copper/zinc-binding family is one. Defects in the...; Region: Cu-Zn_Superoxide_Dismutase; cd00305
633149007199	E-class dimer interface [polypeptide binding]; other site
633149007200	P-class dimer interface [polypeptide binding]; other site
633149007201	active site
633149007202	Cu2+ binding site [ion binding]; other site
633149007203	Zn2+ binding site [ion binding]; other site
633149007204	Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950
633149007205	EamA-like transporter family; Region: EamA; pfam00892
633149007206	Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629
633149007207	SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496
633149007208	dimer interface [polypeptide binding]; other site
633149007209	ssDNA binding site [nucleotide binding]; other site
633149007210	tetramer (dimer of dimers) interface [polypeptide binding]; other site
633149007211	flagellin; Provisional; Region: PRK12802
633149007212	Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669
633149007213	FlaG protein; Region: FlaG; pfam03646
633149007214	flagellin; Reviewed; Region: PRK12687
633149007215	Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669
633149007216	Bacterial flagellin C-terminal helical region; Region: Flagellin_C; pfam00700
633149007217	D-alanyl-D-alanine carboxypeptidase; Region: Peptidase_M15_4; pfam13539
633149007218	Protein of unknown function (DUF2793); Region: DUF2793; pfam10983
633149007219	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5343
633149007220	Anti-sigma-K factor rskA; Region: RskA; pfam10099
633149007221	RNA polymerase sigma factor; Provisional; Region: PRK12514
633149007222	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
633149007223	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
633149007224	DNA binding residues [nucleotide binding]
633149007225	Domain of unknown function (DUF4112); Region: DUF4112; pfam13430
633149007226	Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490
633149007227	putative catalytic site [active]
633149007228	putative metal binding site [ion binding]; other site
633149007229	putative phosphate binding site [ion binding]; other site
633149007230	tRNA nucleotidyltransferase/poly(A) polymerase [Translation, ribosomal structure and biogenesis]; Region: PcnB; COG0617
633149007231	Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398
633149007232	active site
633149007233	NTP binding site [chemical binding]; other site
633149007234	metal binding triad [ion binding]; metal-binding site
633149007235	Coenzyme A pyrophosphatase (CoAse), a member of the Nudix hydrolase superfamily, functions to catalyze the elimination of oxidized inactive CoA, which can inhibit CoA-utilizing enzymes. The need of CoAses mainly arises under conditions of oxidative...; Region: CoAse; cd03426
633149007236	putative active site [active]
633149007237	putative CoA binding site [chemical binding]; other site
633149007238	nudix motif; other site
633149007239	metal binding site [ion binding]; metal-binding site
633149007240	Protein of unknown function (DUF1285); Region: DUF1285; pfam06938
633149007241	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
633149007242	Coenzyme A binding pocket [chemical binding]; other site
633149007243	enoyl-CoA hydratase; Provisional; Region: PRK06688
633149007244	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
633149007245	substrate binding site [chemical binding]; other site
633149007246	oxyanion hole (OAH) forming residues; other site
633149007247	trimer interface [polypeptide binding]; other site
633149007248	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cl15762
633149007249	Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491
633149007250	Escherichia coli exonuclease III (ExoIII) and Neisseria meningitides NExo-like subfamily of the ExoIII family purinic/apyrimidinic (AP) endonucleases; Region: ExoIII-like_AP-endo; cd09086
633149007251	putative catalytic site [active]
633149007252	putative phosphate binding site [ion binding]; other site
633149007253	active site
633149007254	metal binding site A [ion binding]; metal-binding site
633149007255	DNA binding site [nucleotide binding]
633149007256	putative AP binding site [nucleotide binding]; other site
633149007257	putative metal binding site B [ion binding]; other site
633149007258	putative molybdopterin-guanine dinucleotide biosynthesis protein MobB/unknown domain fusion protein; Provisional; Region: PRK14495
633149007259	Bacterial Ig-like domain; Region: Big_5; pfam13205
633149007260	putative pectinesterase; Region: PLN02432; cl01911
633149007261	Response regulator receiver domain; Region: Response_reg; pfam00072
633149007262	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
633149007263	active site
633149007264	phosphorylation site [posttranslational modification]
633149007265	intermolecular recognition site; other site
633149007266	dimerization interface [polypeptide binding]; other site
633149007267	ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: RecN; COG0497
633149007268	ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241
633149007269	Walker A/P-loop; other site
633149007270	ATP binding site [chemical binding]; other site
633149007271	Q-loop/lid; other site
633149007272	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
633149007273	ABC transporter signature motif; other site
633149007274	Walker B; other site
633149007275	D-loop; other site
633149007276	H-loop/switch region; other site
633149007277	outer membrane assembly lipoprotein YfiO; Region: OM_YfiO; TIGR03302
633149007278	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429
633149007279	binding surface
633149007280	TPR motif; other site
633149007281	ribose-phosphate pyrophosphokinase; Provisional; Region: PRK01259
633149007282	N-terminal domain of ribose phosphate pyrophosphokinase; Region: Pribosyltran_N; pfam13793
633149007283	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
633149007284	active site
633149007285	50S ribosomal protein L25/general stress protein Ctc; Reviewed; Region: PRK05618
633149007286	Ribosomal L25/TL5/CTC N-terminal 5S rRNA binding domain; Region: Ribosomal_L25_TL5_CTC; cd00495
633149007287	5S rRNA interface [nucleotide binding]; other site
633149007288	CTC domain interface [polypeptide binding]; other site
633149007289	L16 interface [polypeptide binding]; other site
633149007290	Peptidyl-tRNA hydrolase (PTH) is a monomeric protein that cleaves the ester bond linking the nascent peptide and tRNA when peptidyl-tRNA is released prematurely from the ribosome. This ensures the recycling of peptidyl-tRNAs into tRNAs produced through...; Region: PTH; cd00462
633149007291	putative active site [active]
633149007292	catalytic residue [active]
633149007293	TonB-dependent siderophore receptor; Region: TonB-siderophor; TIGR01783
633149007294	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
633149007295	N-terminal plug; other site
633149007296	ligand-binding site [chemical binding]; other site
633149007297	Uncharacterized iron-regulated membrane protein [Function unknown]; Region: PiuB; COG3182
633149007298	PepSY-associated TM helix; Region: PepSY_TM_2; pfam13703
633149007299	Protein of unknown function (DUF461); Region: DUF461; pfam04314
633149007300	Superoxide dismutase [Inorganic ion transport and metabolism]; Region: SodA; COG0605
633149007301	Iron/manganese superoxide dismutases, alpha-hairpin domain; Region: Sod_Fe_N; pfam00081
633149007302	Iron/manganese superoxide dismutases, C-terminal domain; Region: Sod_Fe_C; pfam02777
633149007303	GTP-binding protein YchF; Reviewed; Region: PRK09601
633149007304	YchF GTPase; Region: YchF; cd01900
633149007305	G1 box; other site
633149007306	GTP/Mg2+ binding site [chemical binding]; other site
633149007307	Switch I region; other site
633149007308	G2 box; other site
633149007309	Switch II region; other site
633149007310	G3 box; other site
633149007311	G4 box; other site
633149007312	G5 box; other site
633149007313	TGS_YchF_C: This subfamily represents TGS domain-containing YchF GTP-binding protein, a universally conserved GTPase whose function is unknown. The N-terminal domain of the YchF protein belongs to the Obg-like family of GTPases, and some members of the...; Region: TGS_YchF_C; cd04867
633149007314	Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876
633149007315	PA: Protease-associated (PA) domain. The PA domain is an insert domain in a diverse fraction of proteases. The significance of the PA domain to many of the proteins in which it is inserted is undetermined. It may be a protein-protein interaction domain; Region: PA; cl08238
633149007316	Predicted aminopeptidases [General function prediction only]; Region: Iap; COG2234
633149007317	PA/protease or protease-like domain interface [polypeptide binding]; other site
633149007318	M28 Zn-Peptidases containing a PA domain insert; Region: M28_like_PA_1; cd05660
633149007319	metal binding site [ion binding]; metal-binding site
633149007320	Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876
633149007321	PA_M28_1_2: Protease-associated (PA) domain, peptidase family M28, subfamily-1, subgroup 2. A subgroup of PA-domain containing proteins belonging to the peptidase family M28. Family M28 contains aminopeptidases and carboxypeptidases, and has co-catalytic...; Region: PA_M28_1_2; cd04821
633149007322	Predicted aminopeptidases [General function prediction only]; Region: Iap; COG2234
633149007323	PA/protease or protease-like domain interface [polypeptide binding]; other site
633149007324	M28 Zn-Peptidases containing a PA domain insert; Region: M28_like_PA_1; cd05660
633149007325	metal binding site [ion binding]; metal-binding site
633149007326	Cytochrome C1 family; Region: Cytochrom_C1; pfam02167
633149007327	cytochrome b; Provisional; Region: CYTB; MTH00145
633149007328	Cytochrome b (N-terminus)/b6/petB:  Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria; Region: Cytochrome_b_N; cd00284
633149007329	interchain domain interface [polypeptide binding]; other site
633149007330	intrachain domain interface; other site
633149007331	heme bH binding site [chemical binding]; other site
633149007332	Qi binding site; other site
633149007333	heme bL binding site [chemical binding]; other site
633149007334	Qo binding site; other site
633149007335	Cytochrome b(C-terminus)/b6/petD:  Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria; Region: cytochrome_b_C; cd00290
633149007336	interchain domain interface [polypeptide binding]; other site
633149007337	intrachain domain interface; other site
633149007338	Qi binding site; other site
633149007339	Qo binding site; other site
633149007340	ubiquinol-cytochrome c reductase, iron-sulfur subunit; Region: Rieske_proteo; TIGR01416
633149007341	Ubiquitinol-cytochrome C reductase Fe-S subunit TAT signal; Region: UCR_Fe-S_N; pfam10399
633149007342	Iron-sulfur protein (ISP) component of the bc(1) complex family, Rieske domain; The Rieske domain is a [2Fe-2S] cluster binding domain involved in electron transfer. The bc(1) complex is a multisubunit enzyme found in many different organisms including...; Region: Rieske_cytochrome_bc1; cd03470
633149007343	[2Fe-2S] cluster binding site [ion binding]; other site
633149007344	Predicted rRNA methylase (SpoU class) [Translation, ribosomal structure and biogenesis]; Region: CspR; COG0219
633149007345	Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876
633149007346	PA_M28_2: Protease-associated (PA) domain, peptidase family M28, subfamily-2. A subfamily of PA-domain containing proteins belonging to the peptidase family M28. Family M28 contains aminopeptidases and carboxypeptidases, and has co-catalytic zinc ions; Region: PA_M28_2; cd04815
633149007347	PA/protease or protease-like domain interface [polypeptide binding]; other site
633149007348	Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876
633149007349	metal binding site [ion binding]; metal-binding site
633149007350	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase; Reviewed; Region: lpxC; PRK13186
633149007351	UDP-3-O-acyl N-acetylglycosamine deacetylase; Region: LpxC; pfam03331
633149007352	Cell division GTPase [Cell division and chromosome partitioning]; Region: FtsZ; COG0206
633149007353	FtsZ is a GTPase that is similar to the eukaryotic tubulins and is essential for cell division in prokaryotes.  FtsZ is capable of polymerizing in a GTP-driven process into structures similar to those formed by tubulin. FtsZ forms a ring-shaped septum at...; Region: FtsZ_type1; cd02201
633149007354	nucleotide binding site [chemical binding]; other site
633149007355	SulA interaction site; other site
633149007356	cell division protein FtsZ, alphaProteobacterial C-terminal extension; Region: FtsZ_alphas_C; TIGR03483
633149007357	TonB-dependent Receptor Plug Domain; Region: Plug; pfam07715
633149007358	Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629
633149007359	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244
633149007360	Cell division ATPase FtsA [Cell division and chromosome partitioning]; Region: ftsA; COG0849
633149007361	Cell division protein FtsA; Region: FtsA; smart00842
633149007362	Cell division protein FtsA; Region: FtsA; pfam14450
633149007363	POTRA domain, FtsQ-type; Region: POTRA_1; pfam08478
633149007364	Cell division protein FtsQ; Region: FtsQ; pfam03799
633149007365	D-alanine--D-alanine ligase; Reviewed; Region: ddl; PRK01372
633149007366	D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820
633149007367	ATP-grasp domain; Region: ATP-grasp_4; cl17255
633149007368	UDP-N-acetylenolpyruvoylglucosamine reductase; Provisional; Region: murB; PRK13905
633149007369	FAD binding domain; Region: FAD_binding_4; pfam01565
633149007370	UDP-N-acetylenolpyruvoylglucosamine reductase, C-terminal domain; Region: MurB_C; pfam02873
633149007371	UDP-N-acetylmuramate--L-alanine ligase; Provisional; Region: murC; PRK00421
633149007372	Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225
633149007373	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
633149007374	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
633149007375	DNA modification methylase [DNA replication, recombination, and repair]; Region: COG0863
633149007376	DNA methylase; Region: N6_N4_Mtase; pfam01555
633149007377	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
633149007378	S-adenosylmethionine binding site [chemical binding]; other site
633149007379	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
633149007380	This family is most closely related to the GT1 family of glycosyltransferases. aviGT4 in Streptomyces viridochromogenes has been shown to be involved in biosynthesis of oligosaccharide antibiotic avilamycin A. Inactivation of aviGT4 resulted in a mutant...; Region: GT1_AviGT4_like; cd03802
633149007381	putative ADP-binding pocket [chemical binding]; other site
633149007382	Glycogen debranching enzyme [Carbohydrate transport and metabolism]; Region: GDB1; COG3408
633149007383	Amylo-alpha-1,6-glucosidase; Region: GDE_C; pfam06202
633149007384	A/G-specific DNA glycosylase [DNA replication, recombination, and repair]; Region: MutY; COG1194
633149007385	endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056
633149007386	minor groove reading motif; other site
633149007387	helix-hairpin-helix signature motif; other site
633149007388	substrate binding pocket [chemical binding]; other site
633149007389	active site
633149007390	iron-sulpphur binding domain in DNA-(apurinic or apyrimidinic site) lyase (subfamily of ENDO3); Region: FES; smart00525
633149007391	DNA glycosylase (MutY in bacteria and hMYH in humans) is responsible for repairing misread  A*oxoG residues to C*G by removing the inappropriately paired adenine base from the DNA backbone. It belongs to the Nudix hydrolase superfamily and is important...; Region: DNA_Glycosylase_C; cd03431
633149007392	DNA binding and oxoG recognition site [nucleotide binding]
633149007393	Protein of unknown function (DUF721); Region: DUF721; cl02324
633149007394	Thioredoxin; Region: Thioredoxin_4; pfam13462
633149007395	DSBA-like thioredoxin domain; Region: DSBA; pfam01323
633149007396	Thioredoxin; Region: Thioredoxin_4; pfam13462
633149007397	Protein-disulfide isomerase [Posttranslational modification, protein turnover, chaperones]; Region: DsbG; COG1651
633149007398	Protein-disulfide isomerase [Posttranslational modification, protein turnover, chaperones]; Region: DsbG; COG1651
633149007399	Thioredoxin; Region: Thioredoxin_4; pfam13462
633149007400	ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278
633149007401	AAA domain; Region: AAA_23; pfam13476
633149007402	Walker A/P-loop; other site
633149007403	ATP binding site [chemical binding]; other site
633149007404	ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278
633149007405	ABC transporter signature motif; other site
633149007406	Walker B; other site
633149007407	D-loop; other site
633149007408	H-loop/switch region; other site
633149007409	queuine tRNA-ribosyltransferase; Provisional; Region: tgt; PRK00112
633149007410	Queuine/archaeosine tRNA-ribosyltransferase [Translation, ribosomal structure and biogenesis]; Region: Tgt; COG0343
633149007411	Putative F0F1-ATPase subunit (ATPase_gene1); Region: ATPase_gene1; pfam09527
633149007412	F0F1 ATP synthase subunit A; Validated; Region: PRK05815
633149007413	F0F1 ATP synthase subunit C; Validated; Region: PRK07558
633149007414	ATP synthase B/B' CF(0); Region: ATP-synt_B; cl17192
633149007415	F0F1 ATP synthase subunit B; Provisional; Region: PRK14475
633149007416	Domain of unknown function (DUF1768); Region: DUF1768; pfam08719
633149007417	short chain dehydrogenase; Provisional; Region: PRK05854
633149007418	retinol dehydrogenase (retinol-DH), Light dependent Protochlorophyllide (Pchlide) OxidoReductase (LPOR) and related proteins, classical (c) SDRs; Region: retinol-DH_like_SDR_c_like; cd05327
633149007419	putative NAD(P) binding site [chemical binding]; other site
633149007420	active site
633149007421	mycofactocin system transcriptional regulator; Region: mycofact_TetR; TIGR03968
633149007422	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
633149007423	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
633149007424	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
633149007425	active site
633149007426	Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613
633149007427	tetramer interface [polypeptide binding]; other site
633149007428	pyridoxal 5'-phosphate binding site [chemical binding]; other site
633149007429	catalytic residue [active]
633149007430	Glycine cleavage system protein P (pyridoxal-binding), N-terminal domain [Amino acid transport and metabolism]; Region: GcvP; COG0403
633149007431	glycine dehydrogenase subunit 1; Validated; Region: PRK00451
633149007432	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
633149007433	catalytic residue [active]
633149007434	Glycine cleavage H-protein. Glycine cleavage H-proteins are part of the glycine cleavage system (GCS) found in bacteria, archea and the mitochondria of eukaryotes. GCS is a multienzyme complex consisting of 4 different components (P-, H-, T- and...; Region: GCS_H; cd06848
633149007435	lipoyl attachment site [posttranslational modification]; other site
633149007436	glycine cleavage system aminomethyltransferase T; Provisional; Region: gcvT; PRK13579
633149007437	Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669
633149007438	Esterases and lipases (includes fungal lipases, cholinesterases, etc.)  These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312
633149007439	alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859
633149007440	Adenosine deaminase [Nucleotide transport and metabolism]; Region: Add; COG1816
633149007441	Adenosine deaminase (ADA) is a monomeric zinc dependent enzyme which catalyzes the irreversible hydrolytic deamination of both adenosine, as well as desoxyadenosine, to ammonia and inosine or desoxyinosine, respectively. ADA plays an important role in...; Region: ADA; cd01320
633149007442	active site
633149007443	purine riboside binding site [chemical binding]; other site
633149007444	PIN domain of the Pyrobaculum aerophilum Pae0151 and Pae2754 proteins and homologs; Region: PIN_Pae0151; cd09873
633149007445	putative active site [active]
633149007446	homotetrameric interface [polypeptide binding]; other site
633149007447	metal binding site [ion binding]; metal-binding site
633149007448	Plasmid stability protein [General function prediction only]; Region: StbC; COG4691
633149007449	LabA_like proteins; Region: LabA_like; cd06167
633149007450	putative metal binding site [ion binding]; other site
633149007451	Arginyl tRNA synthetase N terminal domain; Region: Arg_tRNA_synt_N; pfam03485
633149007452	Arginyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Region: ArgS; COG0018
633149007453	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
633149007454	active site
633149007455	HIGH motif; other site
633149007456	nucleotide binding site [chemical binding]; other site
633149007457	catalytic core domain of arginyl-tRNA synthetases; Region: ArgRS_core; cd00671
633149007458	KMSK motif region; other site
633149007459	Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020
633149007460	tRNA binding surface [nucleotide binding]; other site
633149007461	anticodon binding site; other site
633149007462	4-Hydroxy-3-methylbut-2-enyl diphosphate reductase IspH [Lipid metabolism]; Region: lytB; COG0761
633149007463	4-hydroxy-3-methylbut-2-enyl diphosphate reductase; Reviewed; Region: ispH; PRK01045
633149007464	TspO/MBR family; Region: TspO_MBR; pfam03073
633149007465	Zn-dependent dipeptidase, microsomal dipeptidase homolog [Amino acid transport and metabolism]; Region: COG2355
633149007466	renal dipeptidase (rDP), best studied in mammals and also called membrane or microsomal dipeptidase, is a membrane-bound glycoprotein hydrolyzing dipeptides and is involved in hydrolytic metabolism of penem and carbapenem beta-lactam antibiotics; Region: rDP_like; cd01301
633149007467	active site
633149007468	dimer interface [polypeptide binding]; other site
633149007469	Protein of unknown function (DUF808); Region: DUF808; cl01002
633149007470	coproporphyrinogen III oxidase; Provisional; Region: PRK05330
633149007471	Coproporphyrinogen III oxidase; Region: Coprogen_oxidas; cl17752
633149007472	Domain of unknown function, appears to be related to a diverse group of endonucleases; Region: Endonuclease_DUF559; cd01038
633149007473	putative active site [active]
633149007474	GMP synthase - Glutamine amidotransferase domain [Nucleotide transport and metabolism]; Region: GuaA; COG0518
633149007475	Subgroup of proteins having the Type 1 glutamine amidotransferase (GATase1) domain; Region: GATase1_1; cd01741
633149007476	catalytic triad [active]
633149007477	Antibiotic biosynthesis monooxygenase; Region: ABM; pfam03992
633149007478	Protein involved in catabolism of external DNA [General function prediction only]; Region: ComJ; COG2961
633149007479	DNA topoisomerase type I; Provisional; Region: PHA03101
633149007480	DNA topoisomerase IB, C-terminal catalytic domain. Topoisomerase I promotes the relaxation of both positive and negative DNA superhelical tension by introducing a transient single-stranded break in duplex DNA. This function is vital for the processes of...; Region: Topo_IB_C; cd00659
633149007481	active site
633149007482	DNA binding site [nucleotide binding]
633149007483	Int/Topo IB signature motif; other site
633149007484	catalytic residues [active]
633149007485	Opioid growth factor receptor (OGFr) conserved region; Region: OGFr_N; pfam04664
633149007486	L-threonine 3-dehydrogenase; Validated; Region: tdh; PRK05396
633149007487	Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912
633149007488	NAD(P) binding site [chemical binding]; other site
633149007489	Barstar (barnase inhibitor); Region: Barstar; pfam01337
633149007490	RNAase interaction site [polypeptide binding]; other site
633149007491	2-amino-3-ketobutyrate coenzyme A ligase; Provisional; Region: PRK06939
633149007492	pyridoxal phosphate-dependent acyltransferase, putative; Region: gly_Cac_T_rel; TIGR01825
633149007493	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
633149007494	catalytic residue [active]
633149007495	Membrane-bound lysozyme-inhibitor of c-type lysozyme; Region: MliC; pfam09864
633149007496	Protein of unknown function (DUF4232); Region: DUF4232; pfam14016
633149007497	The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair_10; cd04623
633149007498	FOG: CBS domain [General function prediction only]; Region: COG0517
633149007499	Membrane associated serine protease [Amino acid transport and metabolism]; Region: COG0705
633149007500	Curli production assembly/transport component CsgG; Region: CsgG; cl17434
633149007501	Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612
633149007502	Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675
633149007503	Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193
633149007504	Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612
633149007505	Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193
633149007506	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5388
633149007507	PAS domain; Region: PAS_5; pfam07310
633149007508	Carbonic anhydrases/acetyltransferases, isoleucine patch superfamily [General function prediction only]; Region: PaaY; COG0663
633149007509	Gamma carbonic anhydrase-like: This family is composed of gamma carbonic anhydrase (CA), Ferripyochelin Binding Protein (FBP), E. coli paaY protein, and similar proteins. CAs are zinc-containing enzymes that catalyze the reversible hydration of carbon...; Region: LbH_gamma_CA_like; cd04645
633149007510	trimer interface [polypeptide binding]; other site
633149007511	putative metal binding site [ion binding]; other site
633149007512	PhoH-like protein; Region: PhoH; pfam02562
633149007513	Predicted membrane protein [Function unknown]; Region: COG2259
633149007514	Pirin-related protein [General function prediction only]; Region: COG1741
633149007515	Pirin; Region: Pirin; pfam02678
633149007516	Uncharacterized conserved protein [Function unknown]; Region: COG2968
633149007517	Protein of unknown function (DUF541); Region: SIMPL; pfam04402
633149007518	Opacity protein and related surface antigens [Cell envelope biogenesis, outer membrane]; Region: COG3637
633149007519	nitrous oxide reductase family maturation protein NosD; Region: NosD_copper_fam; TIGR04247
633149007520	FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790
633149007521	Sel1-like repeats; Region: SEL1; smart00671
633149007522	GAF domain-containing protein [Signal transduction mechanisms]; Region: COG1956
633149007523	3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653
633149007524	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
633149007525	NAD(P) binding site [chemical binding]; other site
633149007526	active site
633149007527	Citrate lyase beta subunit [Carbohydrate transport and metabolism]; Region: CitE; COG2301
633149007528	Capsule polysaccharide export protein [Cell envelope biogenesis, outer membrane]; Region: KpsC; COG3563
633149007529	3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK07515
633149007530	Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830
633149007531	dimer interface [polypeptide binding]; other site
633149007532	active site
633149007533	CoA binding pocket [chemical binding]; other site
633149007534	Outer membrane protein beta-barrel domain; Region: OMP_b-brl; pfam13505
633149007535	Outer membrane protein beta-barrel domain; Region: OMP_b-brl; pfam13505
633149007536	2-dehydropantoate 2-reductase; Reviewed; Region: PRK06522
633149007537	Ketopantoate reductase PanE/ApbA; Region: ApbA; pfam02558
633149007538	Ketopantoate reductase PanE/ApbA C terminal; Region: ApbA_C; pfam08546
633149007539	pyruvate phosphate dikinase; Provisional; Region: PRK09279
633149007540	Pyruvate phosphate dikinase, PEP/pyruvate binding domain; Region: PPDK_N; pfam01326
633149007541	PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391
633149007542	PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896
633149007543	Catalase [Inorganic ion transport and metabolism]; Region: KatE; COG0753
633149007544	Catalase-like heme-binding proteins and protein domains; Region: catalase_like; cl09506
633149007545	heme binding pocket [chemical binding]; other site
633149007546	Type 1 glutamine amidotransferase (GATase1)-like domain found in at the C-terminal of several large catalases; Region: GATase1_catalase; cd03132
633149007547	domain interactions; other site
633149007548	glycyl-tRNA synthetase subunit beta; Validated; Region: glyS; PRK01233
633149007549	Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020
633149007550	Class II Glycyl-tRNA synthetase (GlyRS) alpha subunit core catalytic domain. GlyRS functions as a homodimer in eukaryotes, archaea and some bacteria and as a heterotetramer in the remainder of prokaryotes and in arabidopsis. It is responsible for the...; Region: GlyRS_alpha_core; cd00733
633149007551	dimer interface [polypeptide binding]; other site
633149007552	motif 1; other site
633149007553	active site
633149007554	motif 2; other site
633149007555	motif 3; other site
633149007556	Secreted and surface protein containing fasciclin-like repeats [Cell envelope biogenesis, outer membrane]; Region: COG2335
633149007557	Fasciclin domain; Region: Fasciclin; pfam02469
633149007558	4-diphosphocytidyl-2-C-methyl-D-erythritol kinase; Provisional; Region: PRK14608
633149007559	TPR repeat; Region: TPR_11; pfam13414
633149007560	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
633149007561	binding surface
633149007562	TPR motif; other site
633149007563	Tetratricopeptide repeat; Region: TPR_16; pfam13432
633149007564	undecaprenyldiphospho-muramoylpentapeptide beta-N- acetylglucosaminyltransferase; Provisional; Region: murG; PRK00726
633149007565	MurG is an N-acetylglucosaminyltransferase, the last enzyme involved in the intracellular phase of peptidoglycan biosynthesis. It transfers N-acetyl-D-glucosamine (GlcNAc) from UDP-GlcNAc to the C4 hydroxyl of a lipid-linked N-acetylmuramoyl pentapeptide...; Region: GT1_MurG; cd03785
633149007566	active site
633149007567	homodimer interface [polypeptide binding]; other site
633149007568	cell division protein FtsW; Region: ftsW; TIGR02614
633149007569	UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase; Provisional; Region: murD; PRK01390
633149007570	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
633149007571	phospho-N-acetylmuramoyl-pentapeptide-transferase; Provisional; Region: mraY; PRK00108
633149007572	Phospho-N-acetylmuramoyl-pentapeptide-transferase (mraY) is an enzyme responsible for the formation of the first lipid intermediate in the synthesis of bacterial cell wall peptidoglycan. It catalyzes the formation of...; Region: GT_MraY; cd06852
633149007573	Mg++ binding site [ion binding]; other site
633149007574	putative catalytic motif [active]
633149007575	putative substrate binding site [chemical binding]; other site
633149007576	UDP-N-acetylmuramoylalanyl-D-glutamyl-2, 6-diaminopimelate--D-alanyl-D-alanine ligase; Provisional; Region: PRK14093
633149007577	Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225
633149007578	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
633149007579	UDP-N-acetylmuramoylalanyl-D-glutamate--2, 6-diaminopimelate ligase; Provisional; Region: murE; PRK00139
633149007580	Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225
633149007581	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
633149007582	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
633149007583	penicillin-binding protein 2; Region: pbp2_mrdA; TIGR03423
633149007584	Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717
633149007585	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905
633149007586	16S rRNA m(4)C1402 methyltranserfase; Provisional; Region: PRK00050
633149007587	MraW methylase family; Region: Methyltransf_5; cl17771
633149007588	MraZ protein; Region: MraZ; pfam02381
633149007589	MraZ protein; Region: MraZ; pfam02381
633149007590	N-acetyl-anhydromuramyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: ampD; COG3023
633149007591	Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583
633149007592	amidase catalytic site [active]
633149007593	Zn binding residues [ion binding]; other site
633149007594	substrate binding site [chemical binding]; other site
633149007595	Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471
633149007596	Signal peptide peptidase A (SppA) 67K type, a serine protease, has catalytic Ser-Lys dyad; Region: S49_SppA_67K_type; cd07018
633149007597	tandem repeat interface [polypeptide binding]; other site
633149007598	oligomer interface [polypeptide binding]; other site
633149007599	active site residues [active]
633149007600	Signal peptide peptidase A (SppA), a serine protease, has catalytic Ser-Lys dyad; Region: S49_Sppa_N_C; cd07023
633149007601	signal peptide peptidase SppA, 36K type; Region: SppA_dom; TIGR00706
633149007602	oligomer interface [polypeptide binding]; other site
633149007603	tandem repeat interface [polypeptide binding]; other site
633149007604	active site residues [active]
633149007605	Aspartate alpha-decarboxylase or L-aspartate 1-decarboxylase, a pyruvoyl group-dependent  decarboxylase in beta-alanine production; Region: Asp_decarbox; cd06919
633149007606	tetramerization interface [polypeptide binding]; other site
633149007607	active site
633149007608	1-deoxy-D-xylulose-5-phosphate synthase; Provisional; Region: PRK05444
633149007609	Thiamine pyrophosphate (TPP) family, DXS subfamily, TPP-binding module; 1-Deoxy-D-xylulose-5-phosphate synthase (DXS) is a regulatory enzyme of the mevalonate-independent pathway involved in terpenoid biosynthesis. Terpeniods are plant natural products...; Region: TPP_DXS; cd02007
633149007610	TPP-binding site; other site
633149007611	Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033
633149007612	PYR/PP interface [polypeptide binding]; other site
633149007613	dimer interface [polypeptide binding]; other site
633149007614	TPP binding site [chemical binding]; other site
633149007615	Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780
633149007616	Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142
633149007617	Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685
633149007618	substrate binding pocket [chemical binding]; other site
633149007619	chain length determination region; other site
633149007620	substrate-Mg2+ binding site; other site
633149007621	catalytic residues [active]
633149007622	aspartate-rich region 1; other site
633149007623	active site lid residues [active]
633149007624	aspartate-rich region 2; other site
633149007625	tRNA-binding-domain-containing CsaA-like proteins. CsaA is a molecular chaperone with export related activities. CsaA has a putative tRNA binding activity. The functional unit of CsaA is a homodimer and this domain acts as a dimerization domain; Region: tRNA_bind_CsaA; cd02798
633149007626	dimer interface [polypeptide binding]; other site
633149007627	putative tRNA-binding site [nucleotide binding]; other site
633149007628	exodeoxyribonuclease VII small subunit; Provisional; Region: PRK00977
633149007629	Histidine phosphatase domain found in a functionally diverse set of proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP; cd07040
633149007630	catalytic core [active]
633149007631	Deacetylases, including yeast histone deacetylase and acetoin utilization protein [Chromatin structure and dynamics / Secondary metabolites biosynthesis, transport, and catabolism]; Region: AcuC; COG0123
633149007632	Histone deacetylases and histone-like deacetylases, classII; Region: HDAC_classII_2; cd11599
633149007633	putative active site [active]
633149007634	Zn binding site [ion binding]; other site
633149007635	Arginate lyase and other MDR family members; Region: AL_MDR; cd08252
633149007636	zinc-binding alcohol dehydrogenase family protein; Region: adh_fam_1; TIGR02817
633149007637	putative NAD(P) binding site [chemical binding]; other site
633149007638	dimer interface [polypeptide binding]; other site
633149007639	Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583
633149007640	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3825
633149007641	Protein containing von Willebrand factor type A (vWA) domain [General function prediction only]; Region: CoxE; COG3552
633149007642	CsbD-like; Region: CsbD; pfam05532
633149007643	Contains a crystal structure of the Nudix hydrolase from Enterococcus faecalis, which has an unknown function. In general, members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes...; Region: Nudix_Hydrolase_25; cd04684
633149007644	nudix motif; other site
633149007645	Response regulator receiver domain; Region: Response_reg; pfam00072
633149007646	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
633149007647	active site
633149007648	phosphorylation site [posttranslational modification]
633149007649	intermolecular recognition site; other site
633149007650	dimerization interface [polypeptide binding]; other site
633149007651	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920
633149007652	Histidine kinase; Region: HisKA_2; pfam07568
633149007653	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075
633149007654	Mg2+ binding site [ion binding]; other site
633149007655	FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784
633149007656	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
633149007657	active site
633149007658	phosphorylation site [posttranslational modification]
633149007659	intermolecular recognition site; other site
633149007660	dimerization interface [polypeptide binding]; other site
633149007661	CHASE3 domain; Region: CHASE3; pfam05227
633149007662	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
633149007663	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
633149007664	dimer interface [polypeptide binding]; other site
633149007665	phosphorylation site [posttranslational modification]
633149007666	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
633149007667	ATP binding site [chemical binding]; other site
633149007668	Mg2+ binding site [ion binding]; other site
633149007669	G-X-G motif; other site
633149007670	flagellar biosynthesis protein FlhA; Validated; Region: flhA; PRK06012
633149007671	FHIPEP family; Region: FHIPEP; pfam00771
633149007672	Beta-lactamase enzyme family; Region: Beta-lactamase2; pfam13354
633149007673	Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204
633149007674	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
633149007675	Walker A motif; other site
633149007676	ATP binding site [chemical binding]; other site
633149007677	Walker B motif; other site
633149007678	Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954
633149007679	flagellar motor switch protein; Reviewed; Region: PRK08916
633149007680	flagellar assembly protein H; Validated; Region: fliH; PRK06032
633149007681	flagellar motor switch protein G; Validated; Region: fliG; PRK05686
633149007682	FliG C-terminal domain; Region: FliG_C; pfam01706
633149007683	flagellar MS-ring protein; Reviewed; Region: fliF; PRK06007
633149007684	Secretory protein of YscJ/FliF family; Region: YscJ_FliF; cl01907
633149007685	Flagellar M-ring protein C-terminal; Region: YscJ_FliF_C; pfam08345
633149007686	Lysophospholipase [Lipid metabolism]; Region: PldB; COG2267
633149007687	Putative lysophospholipase; Region: Hydrolase_4; pfam12146
633149007688	Uncharacterized subfamily of Uracil-DNA glycosylases; Region: UDG_like_1; cd10033
633149007689	putative uracil binding site [chemical binding]; other site
633149007690	putative active site [active]
633149007691	Protein of unknown function (DUF3253); Region: DUF3253; pfam11625
633149007692	PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria.  Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443
633149007693	CoenzymeA binding site [chemical binding]; other site
633149007694	subunit interaction site [polypeptide binding]; other site
633149007695	PHB binding site; other site
633149007696	Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625
633149007697	GST_N family, Saccharomyces cerevisiae GTT2-like subfamily; composed of predominantly uncharacterized proteins with similarity to the S. cerevisiae GST protein, GTT2. GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing...; Region: GST_N_GTT2_like; cd03051
633149007698	putative C-terminal domain interface [polypeptide binding]; other site
633149007699	putative GSH binding site (G-site) [chemical binding]; other site
633149007700	putative dimer interface [polypeptide binding]; other site
633149007701	C-terminal, alpha helical domain of the Glutathione S-transferase family; Region: GST_C_family; cl02776
633149007702	N-terminal domain interface [polypeptide binding]; other site
633149007703	dimer interface [polypeptide binding]; other site
633149007704	substrate binding pocket (H-site) [chemical binding]; other site
633149007705	Nucleoside permease [Nucleotide transport and metabolism]; Region: NupC; COG1972
633149007706	Na+ dependent nucleoside transporter N-terminus; Region: Nucleos_tra2_N; pfam01773
633149007707	Na+ dependent nucleoside transporter C-terminus; Region: Nucleos_tra2_C; pfam07662
633149007708	adenosylmethionine--8-amino-7-oxononanoate transaminase; Provisional; Region: PRK05964
633149007709	Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610
633149007710	inhibitor-cofactor binding pocket; inhibition site
633149007711	pyridoxal 5'-phosphate binding site [chemical binding]; other site
633149007712	catalytic residue [active]
633149007713	dithiobiotin synthetase; Reviewed; Region: bioD; PRK00090
633149007714	AAA domain; Region: AAA_26; pfam13500
633149007715	8-amino-7-oxononanoate synthase; Reviewed; Region: PRK05958
633149007716	Aminotransferase class I and II; Region: Aminotran_1_2; pfam00155
633149007717	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
633149007718	catalytic residue [active]
633149007719	Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115
633149007720	PyridoxaL 5'-Phosphate Dependent Enzymes class IV (PLPDE_IV). This D-amino acid superfamily, one of five classes of PLPDE, consists of branched-chain amino acid aminotransferases (BCAT), D-amino acid transferases (DAAT), and...; Region: PLPDE_IV; cd00449
633149007721	homodimer interface [polypeptide binding]; other site
633149007722	substrate-cofactor binding pocket; other site
633149007723	pyridoxal 5'-phosphate binding site [chemical binding]; other site
633149007724	catalytic residue [active]
633149007725	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
633149007726	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
633149007727	active site
633149007728	phosphorylation site [posttranslational modification]
633149007729	intermolecular recognition site; other site
633149007730	dimerization interface [polypeptide binding]; other site
633149007731	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
633149007732	DNA binding site [nucleotide binding]
633149007733	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
633149007734	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054
633149007735	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
633149007736	ATP binding site [chemical binding]; other site
633149007737	G-X-G motif; other site
633149007738	pyrroline-5-carboxylate reductase; Reviewed; Region: PRK11880
633149007739	NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; cl17232
633149007740	Putative bacterial sensory transduction regulator; Region: YbjN; cl15834
633149007741	Membrane fusogenic activity; Region: BMFP; pfam04380
633149007742	prolipoprotein diacylglyceryl transferase; Reviewed; Region: PRK00052
633149007743	Uncharacterized conserved protein [Function unknown]; Region: COG1565
633149007744	Multicopper polyphenol oxidase (laccase) [Secondary metabolites biosynthesis, transport and catabolism]; Region: yfiH; COG1496
633149007745	Multi-copper polyphenol oxidoreductase laccase; Region: Cu-oxidase_4; pfam02578
633149007746	Isopentenyl diphosphate isomerase (BS_ypgA, MTH48 and related proteins) [Coenzyme transport and metabolism]; Region: idi; COG1304
633149007747	TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186
633149007748	phosphate binding site [ion binding]; other site
633149007749	Esterases and lipases (includes fungal lipases, cholinesterases, etc.)  These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312
633149007750	Carboxylesterase family; Region: COesterase; pfam00135
633149007751	substrate binding pocket [chemical binding]; other site
633149007752	catalytic triad [active]
633149007753	Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940
633149007754	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012
633149007755	nucleotide binding site [chemical binding]; other site
633149007756	TonB-dependent siderophore receptor; Region: TonB-siderophor; TIGR01783
633149007757	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
633149007758	N-terminal plug; other site
633149007759	ligand-binding site [chemical binding]; other site
633149007760	FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277
633149007761	FAD binding domain; Region: FAD_binding_4; pfam01565
633149007762	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
633149007763	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
633149007764	Transcriptional regulators [Transcription]; Region: FadR; COG2186
633149007765	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
633149007766	DNA-binding site [nucleotide binding]; DNA binding site
633149007767	FCD domain; Region: FCD; pfam07729
633149007768	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
633149007769	Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814
633149007770	Mannitol-1-phosphate/altronate dehydrogenases [Carbohydrate transport and metabolism]; Region: MtlD; COG0246
633149007771	Mannitol dehydrogenase Rossmann domain; Region: Mannitol_dh; pfam01232
633149007772	Mannitol dehydrogenase C-terminal domain; Region: Mannitol_dh_C; pfam08125
633149007773	Gram-negative bacterial tonB protein; Region: TonB; cl10048
633149007774	Protein of unknown function (DUF3297); Region: DUF3297; pfam11730
633149007775	Uncharacterized conserved protein [Function unknown]; Region: COG3334
633149007776	flagellar motor switch protein FliM; Reviewed; Region: fliM; PRK12795
633149007777	Surface presentation of antigens (SPOA); Region: SpoA; pfam01052
633149007778	Flagellar basal body-associated protein FliL; Region: FliL; cl00681
633149007779	flagellar basal body rod protein FlgF; Reviewed; Region: flgF; PRK12689
633149007780	flagellar basal-body rod protein FlgF; Region: flgF; TIGR02490
633149007781	flagellar basal body rod protein FlgG; Reviewed; Region: flgG; PRK12691
633149007782	Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460
633149007783	Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429
633149007784	Domains similar to fish antifreeze type III protein; Region: SAF; cl00555
633149007785	flagellar basal body L-ring protein; Reviewed; Region: flgH; PRK00249
633149007786	Flagellar basal body L-ring protein [Cell motility and secretion]; Region: FlgH; COG2063
633149007787	methionine sulfoxide reductase A; Provisional; Region: PRK00058
633149007788	Esterase/lipase [Lipid metabolism]; Region: Aes; COG0657
633149007789	Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326
633149007790	Glycosyl hydrolases family 2, sugar binding domain; Region: Glyco_hydro_2_N; pfam02837
633149007791	Glycosyl hydrolases family 2; Region: Glyco_hydro_2; pfam00703
633149007792	Glycosyl hydrolases family 2, TIM barrel domain; Region: Glyco_hydro_2_C; pfam02836
633149007793	Bacterial Ig-like domain (group 1); Region: Big_1; cl17740
633149007794	TonB-dependent receptor; Region: TonB-Xanth-Caul; TIGR01782
633149007795	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244
633149007796	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244
633149007797	Rhamnogalacturonan lyase of the polysaccharide lyase family 11; Region: RGL11; cd10318
633149007798	metal binding site [ion binding]; metal-binding site
633149007799	active site
633149007800	Rhamnogalacturan_acetylesterase_like subgroup of SGNH-hydrolases. Rhamnogalacturan acetylesterase removes acetyl esters from rhamnogalacturonan substrates, and renders them susceptible to degradation by rhamnogalacturonases. Rhamnogalacturonans are...; Region: Rhamnogalacturan_acetylesterase_like; cd01821
633149007801	active site
633149007802	catalytic triad [active]
633149007803	Glycosyl hydrolase family 43; Region: GH43_5; cd08984
633149007804	active site
633149007805	Glycosyl hydrolase families: GH43, GH62, GH32, GH68; Region: GH43_62_32_68; cl14647
633149007806	active site
633149007807	Endopygalactorunase [Cell envelope biogenesis, outer membrane]; Region: PGU1; COG5434
633149007808	Domain of unknown function (DUF718); Region: DUF718; pfam05336
633149007809	3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653
633149007810	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
633149007811	NAD(P) binding site [chemical binding]; other site
633149007812	active site
633149007813	Transcriptional regulator [Transcription]; Region: IclR; COG1414
633149007814	helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346
633149007815	Bacterial transcriptional regulator; Region: IclR; pfam01614
633149007816	L-rhamnonate dehydratase; Provisional; Region: PRK15440
633149007817	Mandelate racemase (MR)-like subfamily of the enolase superfamily, subgroup 2. Enzymes of this subgroup share three conserved carboxylate ligands for the essential divalent metal ion (usually Mg2+), two aspartates and a glutamate, and conserved catalytic...; Region: MR_like_2; cd03327
633149007818	putative active site pocket [active]
633149007819	putative metal binding site [ion binding]; other site
633149007820	2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179
633149007821	Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557
633149007822	3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653
633149007823	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
633149007824	NAD(P) binding site [chemical binding]; other site
633149007825	active site
633149007826	Predicted metal-dependent hydrolase of the TIM-barrel fold [General function prediction only]; Region: COG3618
633149007827	Amidohydrolase; Region: Amidohydro_2; pfam04909
633149007828	Na+/melibiose symporter and related transporters [Carbohydrate transport and metabolism]; Region: MelB; COG2211
633149007829	melibiose:sodium symporter; Provisional; Region: PRK10429; cl15392
633149007830	Predicted unsaturated glucuronyl hydrolase involved in regulation of bacterial surface properties, and related proteins [General function prediction only]; Region: COG4225
633149007831	L-lactate dehydrogenase; Provisional; Region: lldD; PRK11197
633149007832	TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186
633149007833	phosphate binding site [ion binding]; other site
633149007834	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
633149007835	putative substrate translocation pore; other site
633149007836	Na+/proline symporter [Amino acid transport and metabolism / General function prediction only]; Region: PutP; COG0591
633149007837	PAS fold; Region: PAS_7; pfam12860
633149007838	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
633149007839	dimer interface [polypeptide binding]; other site
633149007840	phosphorylation site [posttranslational modification]
633149007841	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
633149007842	ATP binding site [chemical binding]; other site
633149007843	Mg2+ binding site [ion binding]; other site
633149007844	G-X-G motif; other site
633149007845	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
633149007846	active site
633149007847	phosphorylation site [posttranslational modification]
633149007848	intermolecular recognition site; other site
633149007849	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
633149007850	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
633149007851	active site
633149007852	phosphorylation site [posttranslational modification]
633149007853	intermolecular recognition site; other site
633149007854	dimerization interface [polypeptide binding]; other site
633149007855	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
633149007856	DNA binding residues [nucleotide binding]
633149007857	dimerization interface [polypeptide binding]; other site
633149007858	Porin subfamily; Region: Porin_2; pfam02530
633149007859	acetyl-CoA synthetase; Provisional; Region: PRK00174
633149007860	Acetyl-CoA synthetase (also known as acetate-CoA ligase and acetyl-activating enzyme); Region: ACS; cd05966
633149007861	active site
633149007862	CoA binding site [chemical binding]; other site
633149007863	acyl-activating enzyme (AAE) consensus motif; other site
633149007864	AMP binding site [chemical binding]; other site
633149007865	acetate binding site [chemical binding]; other site
633149007866	DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127
633149007867	active site
633149007868	catalytic site [active]
633149007869	substrate binding site [chemical binding]; other site
633149007870	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
633149007871	This family is most closely related to the GT1 family of glycosyltransferases. aviGT4 in Streptomyces viridochromogenes has been shown to be involved in biosynthesis of oligosaccharide antibiotic avilamycin A. Inactivation of aviGT4 resulted in a mutant...; Region: GT1_AviGT4_like; cd03802
633149007872	putative ADP-binding pocket [chemical binding]; other site
633149007873	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
633149007874	active site
633149007875	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
633149007876	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
633149007877	active site
633149007878	GlcNAc-PI de-N-acetylase; Region: PIG-L; pfam02585
633149007879	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173
633149007880	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
633149007881	active site
633149007882	Protein of unknown function (DUF3478); Region: DUF3478; pfam11964
633149007883	esterase, PHB depolymerase family; Region: esterase_phb; TIGR01840
633149007884	Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326
633149007885	SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cl01053
633149007886	active site
633149007887	catalytic triad [active]
633149007888	oxyanion hole [active]
633149007889	3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557
633149007890	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
633149007891	NAD(P) binding site [chemical binding]; other site
633149007892	active site
633149007893	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
633149007894	D-galactonate transporter; Region: 2A0114; TIGR00893
633149007895	putative substrate translocation pore; other site
633149007896	Alginate lyase; Region: Alginate_lyase; pfam05426
633149007897	Heparinase II/III-like protein; Region: Hepar_II_III; pfam07940
633149007898	nitrous oxide reductase family maturation protein NosD; Region: NosD_copper_fam; TIGR04247
633149007899	TonB-dependent receptor; Region: TonB-Xanth-Caul; TIGR01782
633149007900	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244
633149007901	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244
633149007902	Transcriptional regulators [Transcription]; Region: FadR; COG2186
633149007903	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
633149007904	DNA-binding site [nucleotide binding]; DNA binding site
633149007905	FCD domain; Region: FCD; pfam07729
633149007906	Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; COG0475
633149007907	Cupin-like domain; Region: Cupin_8; pfam13621
633149007908	Tryptophan halogenase; Region: Trp_halogenase; pfam04820
633149007909	TonB-dependent receptor; Region: TonB-Xanth-Caul; TIGR01782
633149007910	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244
633149007911	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244
633149007912	Alpha amylase catalytic domain family; Region: AmyAc_family; cl07893
633149007913	Glycosidases [Carbohydrate transport and metabolism]; Region: AmyA; COG0366
633149007914	Alpha amylase catalytic domain found in bacterial cyclomaltodextrinases and related proteins; Region: AmyAc_bac_CMD_like_2; cd11339
633149007915	active site
633149007916	catalytic site [active]
633149007917	alpha,alpha-phosphotrehalase; Region: trehalose_treC; TIGR02403
633149007918	Alpha amylase catalytic domain found in oligo-1,6-glucosidase (also called isomaltase; sucrase-isomaltase; alpha-limit dextrinase) and related proteins; Region: AmyAc_OligoGlu; cd11330
633149007919	active site
633149007920	catalytic site [active]
633149007921	Domain of unknown function (DUF3459); Region: DUF3459; pfam11941
633149007922	Transcriptional regulators [Transcription]; Region: PurR; COG1609
633149007923	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
633149007924	DNA binding site [nucleotide binding]
633149007925	Ligand binding domain of a transcription regulator of cellulose genes, CelR, which is highly homologous to the LacI-GalR family of bacterial transcription regulators; Region: PBP1_CelR; cd06295
633149007926	putative dimerization interface [polypeptide binding]; other site
633149007927	putative ligand binding site [chemical binding]; other site
633149007928	Glycoside hydrolase 97; Region: Glyco_hydro_97; pfam10566
633149007929	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
633149007930	GPH family sucrose/H+ symporter; Region: GPH_sucrose; TIGR01301
633149007931	Glycoside hydrolase family 15, N-terminal domain; Region: GH15_N; cd07430
633149007932	Domain interface; other site
633149007933	glucan 1,4-alpha-glucosidase; Region: glucan_glucosid; TIGR01535
633149007934	Glycosyl hydrolases family 15; Region: Glyco_hydro_15; pfam00723
633149007935	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
633149007936	AAA domain; Region: AAA_21; pfam13304
633149007937	Walker A/P-loop; other site
633149007938	ATP binding site [chemical binding]; other site
633149007939	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
633149007940	ABC transporter signature motif; other site
633149007941	Walker B; other site
633149007942	D-loop; other site
633149007943	H-loop/switch region; other site
633149007944	HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085
633149007945	active site
633149007946	Divergent AAA domain; Region: AAA_4; pfam04326
633149007947	Predicted P-loop ATPase [General function prediction only]; Region: COG4928
633149007948	KAP family P-loop domain; Region: KAP_NTPase; pfam07693
633149007949	Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961
633149007950	Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cd00338
633149007951	catalytic residues [active]
633149007952	catalytic nucleophile [active]
633149007953	Recombinase; Region: Recombinase; pfam07508
633149007954	Recombinase zinc beta ribbon domain; Region: Zn_ribbon_recom; pfam13408
633149007955	LytTr DNA-binding domain; Region: LytTR; pfam04397
633149007956	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
633149007957	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
633149007958	Concanavalin A-like lectin/glucanases superfamily; Region: Laminin_G_3; pfam13385
633149007959	Glycosyl hydrolases family 2, sugar binding domain; Region: Glyco_hydro_2_N; pfam02837
633149007960	Glycosyl hydrolases family 2; Region: Glyco_hydro_2; pfam00703
633149007961	Glycosyl hydrolases family 2, TIM barrel domain; Region: Glyco_hydro_2_C; pfam02836
633149007962	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
633149007963	putative substrate translocation pore; other site
633149007964	glucose/galactose transporter; Region: gluP; TIGR01272
633149007965	Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940
633149007966	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037
633149007967	nucleotide binding site [chemical binding]; other site
633149007968	Tryptophan halogenase; Region: Trp_halogenase; pfam04820
633149007969	TonB-dependent receptor; Region: TonB-Xanth-Caul; TIGR01782
633149007970	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244
633149007971	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244
633149007972	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
633149007973	putative substrate translocation pore; other site
633149007974	Major Facilitator Superfamily; Region: MFS_1; pfam07690
633149007975	Beta-glucosidase-related glycosidases [Carbohydrate transport and metabolism]; Region: BglX; COG1472
633149007976	Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; pfam00933
633149007977	Glycosyl hydrolase family 3 C-terminal domain; Region: Glyco_hydro_3_C; pfam01915
633149007978	Transcriptional regulators [Transcription]; Region: PurR; COG1609
633149007979	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
633149007980	Ligand-binding domain of DNA transcription repressor SalR, a member of the LacI-GalR family of bacterial transcription regulators; Region: PBP1_SalR; cd01545
633149007981	putative ligand binding site [chemical binding]; other site
633149007982	putative dimerization interface [polypeptide binding]; other site
633149007983	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244
633149007984	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244
633149007985	Beta-xylosidase [Carbohydrate transport and metabolism]; Region: XynB; COG3507
633149007986	Glycosyl hydrolase family 43, beta-D-xylosidase; Region: GH43_XYL_3; cd09002
633149007987	active site
633149007988	This group contains class II terpene cyclases, protein prenyltransferases beta subunit, two broadly specific proteinase inhibitors alpha2-macroglobulin (alpha (2)-M) and pregnancy zone protein (PZP) and, the C3 C4 and C5 components of vertebrate...; Region: ISOPREN_C2_like; cl08267
633149007989	Pectic acid lyase; Region: Pec_lyase; pfam09492
633149007990	Transcriptional regulators [Transcription]; Region: PurR; COG1609
633149007991	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
633149007992	DNA binding site [nucleotide binding]
633149007993	domain linker motif; other site
633149007994	Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011
633149007995	Fumarylacetoacetate (FAA) hydrolase family protein [General function prediction only]; Region: COG3970
633149007996	Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557
633149007997	3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653
633149007998	classical (c) SDRs; Region: SDR_c; cd05233
633149007999	NAD(P) binding site [chemical binding]; other site
633149008000	active site
633149008001	D-xylose transporter XylE; Provisional; Region: xylE; PRK10077
633149008002	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
633149008003	putative substrate translocation pore; other site
633149008004	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
633149008005	Bacillus subtilis NADP+-dependent alpha-ketoglutaric semialdehyde dehydrogenase ycbD-like; Region: ALDH_KGSADH-YcbD; cd07097
633149008006	Aldehyde dehydrogenase family; Region: Aldedh; pfam00171
633149008007	NAD(P) binding site [chemical binding]; other site
633149008008	catalytic residues [active]
633149008009	SMP-30/Gluconolaconase/LRE-like region; Region: SGL; pfam08450
633149008010	aldose 1-epimerase, similar to Escherichia coli YphB; Region: Aldose_epim_Ec_YphB; cd09021
633149008011	active site
633149008012	catalytic residues [active]
633149008013	This group contains class II terpene cyclases, protein prenyltransferases beta subunit, two broadly specific proteinase inhibitors alpha2-macroglobulin (alpha (2)-M) and pregnancy zone protein (PZP) and, the C3 C4 and C5 components of vertebrate...; Region: ISOPREN_C2_like; cl08267
633149008014	Pectic acid lyase; Region: Pec_lyase; pfam09492
633149008015	Rhamnogalacturan_acetylesterase_like subgroup of SGNH-hydrolases. Rhamnogalacturan acetylesterase removes acetyl esters from rhamnogalacturonan substrates, and renders them susceptible to degradation by rhamnogalacturonases. Rhamnogalacturonans are...; Region: Rhamnogalacturan_acetylesterase_like; cd01821
633149008016	active site
633149008017	catalytic triad [active]
633149008018	Transcriptional regulators [Transcription]; Region: FadR; COG2186
633149008019	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
633149008020	DNA-binding site [nucleotide binding]; DNA binding site
633149008021	This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895
633149008022	dihydroxy-acid dehydratase; Provisional; Region: PRK13017
633149008023	Uncharacterized conserved protein [Function unknown]; Region: COG4544
633149008024	DNA Polymerase Y-family; Region: PolY_like; cd03468
633149008025	Nucleotidyltransferase/DNA polymerase involved in DNA repair [DNA replication, recombination, and repair]; Region: DinP; COG0389
633149008026	DNA binding site [nucleotide binding]
633149008027	error-prone DNA polymerase; Validated; Region: dnaE2; PRK05672
633149008028	Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III at DnaE2 gene; Region: PHP_PolIIIA_DnaE2; cd07434
633149008029	putative active site [active]
633149008030	putative PHP Thumb interface [polypeptide binding]; other site
633149008031	DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485
633149008032	generic binding surface II; other site
633149008033	generic binding surface I; other site
633149008034	galactarate dehydratase; Region: galactar-dH20; TIGR03248
633149008035	Domains similar to fish antifreeze type III protein; Region: SAF_AH_GD; cd11613
633149008036	D-galactarate dehydratase / Altronate hydrolase, C terminus; Region: GD_AH_C; pfam04295
633149008037	Domain of unknown function (DUF305); Region: DUF305; pfam03713
633149008038	choice-of-anchor B domain; Region: choice_anch_B; TIGR04312
633149008039	Glutathionylspermidine synthase [Amino acid transport and metabolism]; Region: Gsp; COG0754
633149008040	PspA/IM30 family; Region: PspA_IM30; pfam04012
633149008041	Uncharacterized protein conserved in bacteria (DUF2170); Region: DUF2170; cl01551
633149008042	Protein of unknown function (DUF2491); Region: DUF2491; pfam10679
633149008043	Domain of Unknown Function (DUF350); Region: DUF350; pfam03994
633149008044	Protein of unknown function (DUF1190); Region: DUF1190; cl10031
633149008045	Predicted UDP-glucose 6-dehydrogenase [Cell envelope biogenesis, outer membrane]; Region: Ugd; COG1004
633149008046	NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210
633149008047	UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984
633149008048	UDP binding domain; Region: UDPG_MGDP_dh_C; smart00984
633149008049	NAD(P) transhydrogenase beta subunit; Region: PNTB; pfam02233
633149008050	NAD/NADP transhydrogenase beta subunit [Energy production and conversion]; Region: PntB; COG1282
633149008051	Domain of unknown function (DUF3814); Region: DUF3814; pfam12769
633149008052	NAD/NADP transhydrogenase alpha subunit [Energy production and conversion]; Region: PntA; COG3288
633149008053	Rubrum transdehydrogenase NAD-binding and catalytic domains; Region: Rubrum_tdh; cd05304
633149008054	ligand binding site [chemical binding]; other site
633149008055	homodimer interface [polypeptide binding]; other site
633149008056	NAD(P) binding site [chemical binding]; other site
633149008057	trimer interface B [polypeptide binding]; other site
633149008058	trimer interface A [polypeptide binding]; other site
633149008059	Bacterial aa3 type cytochrome c oxidase subunit IV; Region: COX4_pro_2; pfam07835
633149008060	oligoendopeptidase, pepF/M3 family; Region: M3_fam_3; TIGR02290
633149008061	Peptidase Gluzincin family (thermolysin-like proteinases, TLPs) includes peptidases M1, M2, M3, M4, M13, M32 and M36 (fungalysins); Region: GluZincin; cl14813
633149008062	Peptidase family M3B Oligopeptidase F (PepF); Region: M3B_PepF_5; cd09610
633149008063	active site
633149008064	Zn binding site [ion binding]; other site
633149008065	Protein of unknown function (DUF1203); Region: DUF1203; pfam06718
633149008066	Domain of unknown function (DUF4153); Region: DUF4153; pfam13687
633149008067	Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204
633149008068	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
633149008069	active site
633149008070	phosphorylation site [posttranslational modification]
633149008071	intermolecular recognition site; other site
633149008072	dimerization interface [polypeptide binding]; other site
633149008073	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
633149008074	Walker A motif; other site
633149008075	ATP binding site [chemical binding]; other site
633149008076	Walker B motif; other site
633149008077	arginine finger; other site
633149008078	Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954
633149008079	TonB-dependent Receptor Plug Domain; Region: Plug; pfam07715
633149008080	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
633149008081	Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248
633149008082	active site
633149008083	catalytic tetrad [active]
633149008084	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
633149008085	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
633149008086	Beta-lactamase; Region: Beta-lactamase; pfam00144
633149008087	Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680
633149008088	hypothetical protein; Provisional; Region: PRK13694
633149008089	50S ribosomal protein L36; Validated; Region: rpmJ; PRK00831
633149008090	Putative transcriptional regulators (Ypuh-like); Region: DUF387; pfam04079
633149008091	Rec8/ScpA/Scc1-like protein (kleisin family) [Replication,    recombination, and repair]; Region: scpA; COG1354
633149008092	Beta-glucosidase-related glycosidases [Carbohydrate transport and metabolism]; Region: BglX; COG1472
633149008093	Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; cl07971
633149008094	Sporulation related domain; Region: SPOR; pfam05036
633149008095	deoxyguanosinetriphosphate triphosphohydrolase-like protein; Provisional; Region: PRK01286
633149008096	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
633149008097	Zn2+ binding site [ion binding]; other site
633149008098	Mg2+ binding site [ion binding]; other site
633149008099	Phosphohydrolase-associated domain; Region: HD_assoc; pfam13286
633149008100	Fe-S cluster assembly scaffold protein [Posttranslational modification, protein turnover, chaperones]; Region: sufA; COG0316
633149008101	Flagellar hook-basal body complex protein FliE; Region: FliE; cl09139
633149008102	flagellar basal body rod protein FlgC; Reviewed; Region: flgC; PRK05681
633149008103	Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429
633149008104	flagellar basal body rod protein FlgB; Reviewed; Region: flgB; PRK06004
633149008105	flagellar basal body rod protein FlgB; Reviewed; Region: flgB; PRK07182
633149008106	Flagellar biosynthesis protein, FliO; Region: FliO; cl01247
633149008107	flagellar biosynthesis protein FliP; Reviewed; Region: fliP; PRK05699
633149008108	Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591
633149008109	IHF dimer interface [polypeptide binding]; other site
633149008110	IHF - DNA interface [nucleotide binding]; other site
633149008111	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5349
633149008112	Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010
633149008113	Cytochrome c; Region: Cytochrom_C; pfam00034
633149008114	NADPH-dependent FMN reductase; Region: FMN_red; pfam03358
633149008115	Putative NADPH-quinone reductase (modulator of drug activity B) [General function prediction only]; Region: MdaB; COG2249
633149008116	Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204
633149008117	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
633149008118	active site
633149008119	phosphorylation site [posttranslational modification]
633149008120	intermolecular recognition site; other site
633149008121	dimerization interface [polypeptide binding]; other site
633149008122	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
633149008123	Walker A motif; other site
633149008124	ATP binding site [chemical binding]; other site
633149008125	Walker B motif; other site
633149008126	arginine finger; other site
633149008127	Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954
633149008128	Signal transduction histidine kinase regulating C4-dicarboxylate transport system [Signal transduction mechanisms]; Region: COG4191
633149008129	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
633149008130	dimer interface [polypeptide binding]; other site
633149008131	phosphorylation site [posttranslational modification]
633149008132	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
633149008133	ATP binding site [chemical binding]; other site
633149008134	Mg2+ binding site [ion binding]; other site
633149008135	G-X-G motif; other site
633149008136	Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301
633149008137	Sodium:dicarboxylate symporter family; Region: SDF; cl00573
633149008138	TonB-dependent Receptor Plug Domain; Region: Plug; cl08461
633149008139	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244
633149008140	Deacetylases, including yeast histone deacetylase and acetoin utilization protein [Chromatin structure and dynamics / Secondary metabolites biosynthesis, transport, and catabolism]; Region: AcuC; COG0123
633149008141	Histone deacetylase class IV also known as histone deacetylase 11; Region: HDAC_classIV; cd09993
633149008142	putative active site [active]
633149008143	Zn binding site [ion binding]; other site
633149008144	2'-5' RNA ligase superfamily; Region: 2_5_RNA_ligase2; pfam13563
633149008145	Domain of unknown function (DUF4281); Region: DUF4281; pfam14108
633149008146	DEAD/DEAH box helicase; Region: DEAD; pfam00270
633149008147	ATP binding site [chemical binding]; other site
633149008148	putative Mg++ binding site [ion binding]; other site
633149008149	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
633149008150	nucleotide binding region [chemical binding]; other site
633149008151	ATP-binding site [chemical binding]; other site
633149008152	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
633149008153	RNA binding surface [nucleotide binding]; other site
633149008154	YceI-like domain; Region: YceI; smart00867
633149008155	Ferredoxin [Energy production and conversion]; Region: COG1146
633149008156	4Fe-4S binding domain; Region: Fer4; pfam00037
633149008157	Domain of unknown function (DUF3470); Region: DUF3470; pfam11953
633149008158	Transcriptional regulators, similar to M. xanthus CarD [Transcription]; Region: COG1329
633149008159	Predicted integral membrane protein (DUF2189); Region: DUF2189; cl02291
633149008160	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
633149008161	dimer interface [polypeptide binding]; other site
633149008162	phosphorylation site [posttranslational modification]
633149008163	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
633149008164	ATP binding site [chemical binding]; other site
633149008165	Mg2+ binding site [ion binding]; other site
633149008166	G-X-G motif; other site
633149008167	FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784
633149008168	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
633149008169	active site
633149008170	phosphorylation site [posttranslational modification]
633149008171	intermolecular recognition site; other site
633149008172	dimerization interface [polypeptide binding]; other site
633149008173	Deoxyribodipyrimidine photolyase [DNA replication, recombination, and repair]; Region: PhrB; COG0415
633149008174	flagellar biosynthesis protein FlhB; Reviewed; Region: flhB; PRK05702
633149008175	Uncharacterized homolog of the cytoplasmic domain of flagellar protein FhlB [Function unknown]; Region: COG2257
633149008176	flagellar biosynthesis protein FliR; Reviewed; Region: fliR; PRK05701
633149008177	flagellar biosynthesis protein FliQ; Reviewed; Region: fliQ; PRK06010
633149008178	Predicted acyltransferases [Lipid metabolism]; Region: COG1835
633149008179	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
633149008180	This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587
633149008181	active site
633149008182	3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK06816
633149008183	"initiating" condensing enzymes are a subclass of decarboxylating condensing enzymes, including beta-ketoacyl [ACP] synthase, type III and polyketide synthases, type III, which include chalcone synthase and related enzymes. They are...; Region: init_cond_enzymes; cd00827
633149008184	dimer interface [polypeptide binding]; other site
633149008185	active site
633149008186	Heme oxygenase catalyzes the rate limiting step in the degradation of heme to bilirubin, it is essential for recycling of iron from heme. Heme is used as a substrate and cofactor for its own degradation to biliverdin, iron, and carbon monoxide. This...; Region: HemeO; cl17299
633149008187	heme binding pocket [chemical binding]; other site
633149008188	Prephenate dehydrogenase [Amino acid transport and metabolism]; Region: TyrA; COG0287
633149008189	arogenate dehydrogenase; Region: PLN02256
633149008190	dihydroorotase; Validated; Region: PRK09060
633149008191	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
633149008192	Dihydroorotase (DHOase), subgroup IIb; DHOases catalyze the reversible interconversion of carbamoyl aspartate to dihydroorotate, a key reaction in pyrimidine biosynthesis. This group contains the archeal members of the DHOase family; Region: DHOase_IIb; cd01318
633149008193	active site
633149008194	Lipopolysaccharide heptosyltransferase is involved in the biosynthesis of lipooligosaccharide (LOS). Lipopolysaccharide (LPS) is a major component of the outer membrane of gram-negative bacteria. LPS heptosyltransferase transfers heptose molecules from...; Region: GT1_LPS_heptosyltransferase; cd03789
633149008195	ADP-heptose:LPS heptosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaF; COG0859
633149008196	putative active site [active]
633149008197	Predicted aminomethyltransferase related to GcvT [General function prediction only]; Region: COG0354
633149008198	folate-binding protein YgfZ; Region: ygfZ_signature; TIGR03317
633149008199	Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669
633149008200	Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cd00657
633149008201	dinuclear metal binding motif [ion binding]; other site
633149008202	Methyladenine glycosylase; Region: Adenine_glyco; pfam03352
633149008203	bacterial Ribonuclease HII-like; Region: RNase_HII_bacteria_HII_like; cd07182
633149008204	RNA/DNA hybrid binding site [nucleotide binding]; other site
633149008205	active site
633149008206	Adenine-specific DNA methylase [DNA replication, recombination, and repair]; Region: COG3392
633149008207	D12 class N6 adenine-specific DNA methyltransferase; Region: MethyltransfD12; cl17344
633149008208	pyruvate kinase; Provisional; Region: PRK06247
633149008209	Pyruvate kinase (PK):  Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl17342
633149008210	domain interfaces; other site
633149008211	active site
633149008212	Sulfatase; Region: Sulfatase; cl17466
633149008213	Sulfatase; Region: Sulfatase; cl17466
633149008214	Bacterial protein of unknown function (DUF839); Region: DUF839; pfam05787
633149008215	photosynthetic reaction center subunit M; Provisional; Region: PRK14504
633149008216	pheophytin binding site; other site
633149008217	chlorophyll binding site; other site
633149008218	quinone binding site; other site
633149008219	Fe binding site [ion binding]; other site
633149008220	Subunit L of bacterial photosynthetic reaction center; Region: Photo-RC_L; cd09290
633149008221	subunit M interface; other site
633149008222	subunit H interface; other site
633149008223	quinone binding site; other site
633149008224	bacteriopheophytin binding site; other site
633149008225	bacteriochlorophyll binding site; other site
633149008226	cytochrome C subunit interface; other site
633149008227	Fe binding site [ion binding]; other site
633149008228	Antenna complex alpha/beta subunit; Region: LHC; pfam00556
633149008229	The nitrogenase enzyme system catalyzes the ATP-dependent reduction of dinitrogen to ammonia.  This group contains both alpha and beta subunits of component 1 of the three known genetically distinct types of nitrogenase systems: a molybdenum-dependent; Region: Oxidoreductase_nitrogenase; cl02775
633149008230	chlorophyllide reductase subunit Z; Region: BchZ; TIGR02014
633149008231	Proto-chlorophyllide reductase 57 kD subunit; Region: PCP_red; pfam08369
633149008232	chlorophyllide reductase subunit Y; Region: BchY; TIGR02015
633149008233	Chlide_reductase_Y : Y subunit of chlorophyllide (chlide) reductase (BchY).  Chlide reductase participates in photosynthetic pigment synthesis playing a role in the conversion of chlorophylls(Chl) into bacteriochlorophylls (BChl). Chlide reductase...; Region: Chlide_reductase_Y; cd01980
633149008234	The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203
633149008235	chlorophyllide reductase iron protein subunit X; Region: BchX; TIGR02016
633149008236	2-desacetyl-2-hydroxyethyl bacteriochlorophyllide A dehydrogenase; Region: bchC; TIGR01202
633149008237	2-desacetyl-2-hydroxyethyl bacteriochlorophyllide and other MDR family members; Region: 2-desacetyl-2-hydroxyethyl_bacteriochlorophyllide_; cd08255
633149008238	putative NAD(P) binding site [chemical binding]; other site
633149008239	O-methyltransferase; Region: Methyltransf_2; pfam00891
633149008240	Methyltransferase domain; Region: Methyltransf_23; pfam13489
633149008241	phytoene desaturase; Region: crtI_fam; TIGR02734
633149008242	Hydroxyneurosporene synthase (CrtC); Region: CrtC; pfam07143
633149008243	putative magnesium chelatase accessory protein; Region: bchO_mg_che_rel; TIGR03056
633149008244	magnesium chelatase subunit D; Provisional; Region: bchD; PRK13406
633149008245	Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057
633149008246	metal ion-dependent adhesion site (MIDAS); other site
633149008247	magnesium chelatase subunit I; Provisional; Region: bchI; PRK13407
633149008248	Magnesium chelatase, subunit ChlI; Region: Mg_chelatase; pfam01078
633149008249	Protein of unknown function (DUF3422); Region: DUF3422; pfam11902
633149008250	Cytochrome c2 [Energy production and conversion]; Region: COG3474
633149008251	geranylgeranyl reductase; Region: BchP-ChlP; TIGR02023
633149008252	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
633149008253	PUCC protein; Region: PUCC; pfam03209
633149008254	bacteriochlorophyll/chlorophyll a synthase; Reviewed; Region: PRK07566
633149008255	UbiA prenyltransferase family; Region: UbiA; pfam01040
633149008256	transcriptional regulator PpsR; Region: PpsR-CrtJ; TIGR02040
633149008257	PAS domain; Region: PAS_8; pfam13188
633149008258	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
633149008259	putative active site [active]
633149008260	heme pocket [chemical binding]; other site
633149008261	Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954
633149008262	B12 binding domain; Region: B12-binding_2; cl03653
633149008263	B12 binding domain; Region: B12-binding; pfam02310
633149008264	B12 binding site [chemical binding]; other site
633149008265	2-vinyl bacteriochlorophyllide hydratase (BCHF); Region: BCHF; pfam07284
633149008266	light-independent protochlorophyllide reductase subunit N; Provisional; Region: PRK02842
633149008267	light-independent protochlorophyllide reductase, N subunit; Region: DPOR_bchN; TIGR01279
633149008268	light-independent protochlorophyllide reductase subunit B; Provisional; Region: PRK02910
633149008269	Pchlide_reductase_B: B protein of the NB protein complex of Protochlorophyllide (Pchlide)_reductase. Pchlide reductase catalyzes the reductive formation of chlorophyllide (chlide) from protochlorophyllide (pchlide) during biosynthesis of chlorophylls and...; Region: Pchlide_reductase_B; cd01981
633149008270	Proto-chlorophyllide reductase 57 kD subunit; Region: PCP_red; pfam08369
633149008271	magnesium chelatase subunit H; Provisional; Region: bchH; PRK13405
633149008272	CobN subunit of cobaltochelatase, bchH and chlH subunits of magnesium chelatases, and similar proteins; Region: CobN_like; cd10150
633149008273	protochlorophyllide reductase iron-sulfur ATP-binding protein; Provisional; Region: chlL; PRK13185
633149008274	This family of proteins contains bchL and chlL. Protochlorophyllide reductase catalyzes the reductive formation of chlorophyllide from protochlorophyllide during biosynthesis of chlorophylls and bacteriochlorophylls. Three genes, bchL, bchN and bchB, are...; Region: Bchl_like; cd02032
633149008275	P-loop; other site
633149008276	Mg-protoporphyrin IX methyl transferase; Validated; Region: PRK07580
633149008277	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173
633149008278	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
633149008279	S-adenosylmethionine binding site [chemical binding]; other site
633149008280	Magnesium-protoporphyrin IX methyltransferase C-terminus; Region: Mg-por_mtran_C; pfam07109
633149008281	PUCC protein; Region: PUCC; pfam03209
633149008282	Photosynthetic reaction center (RC) complex, subunit H;  RC is an integral membrane protein-pigment complex which catalyzes light-induced reduction of ubiquinone to ubiquinol, generating a transmembrane electrochemical gradient of protons used to produce...; Region: PRCH; cl17581
633149008283	subunit C interaction residues; other site
633149008284	photosynthetic reaction center, subunit H, bacterial; Region: puhA; TIGR01150
633149008285	subunit M interaction residues [polypeptide binding]; other site
633149008286	subunit L interaction residues [polypeptide binding]; other site
633149008287	putative proton transfer pathway, P1; other site
633149008288	putative proton transfer pathway, P2; other site
633149008289	Bacterial PH domain; Region: DUF304; pfam03703
633149008290	putative photosynthetic complex assembly protein; Region: photo_alph_chp1; TIGR03054
633149008291	Aerobic Cyclase System Fe-containing subunit (ACSF), ferritin-like diiron-binding domain; Region: ACSF; cd01047
633149008292	diiron binding motif [ion binding]; other site
633149008293	Protein of unknown function (DUF3623); Region: DUF3623; pfam12291
633149008294	pyridoxal phosphate-dependent acyltransferase, putative; Region: gly_Cac_T_rel; TIGR01825
633149008295	KBL_like; this family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to serine palmitoyltransferase (SPT), 5-aminolevulinate synthase (ALAS); Region: KBL_like; cd06454
633149008296	substrate-cofactor binding pocket; other site
633149008297	pyridoxal 5'-phosphate binding site [chemical binding]; other site
633149008298	catalytic residue [active]
633149008299	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
633149008300	Novel bacterial esterase that cleaves esters on halogenated cyclic compounds; Region: Esterase_713_like; cl17303
633149008301	catalytic site [active]
633149008302	Predicted integral membrane protein (DUF2189); Region: DUF2189; cl02291
633149008303	Protein of unknown function (DUF1625); Region: DUF1625; pfam07787
633149008304	Teichoic acid biosynthesis proteins [Cell envelope biogenesis, outer membrane]; Region: WecG; COG1922
633149008305	The glycosyltransferase WecG/TagA superfamily contains Escherichia coli WecG, Bacillus subtilis TagA and related proteins. E. coli WecG is believed to be a UDP-N-acetyl-D-mannosaminuronic acid transferase, and is involved in enterobacterial common...; Region: Glyco_transf_WecG_TagA; cd06533
633149008306	beta-D-glucoside glucohydrolase; Provisional; Region: PRK15098
633149008307	Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; pfam00933
633149008308	Fibronectin type III-like domain; Region: Fn3-like; pfam14310
633149008309	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
633149008310	putative substrate translocation pore; other site
633149008311	L-fucose transporter; Provisional; Region: PRK10133; cl17665
633149008312	Alpha amylase catalytic domain found in oligo-1,6-glucosidase (also called isomaltase; sucrase-isomaltase; alpha-limit dextrinase) and related proteins; Region: AmyAc_OligoGlu; cd11330
633149008313	Glycosidases [Carbohydrate transport and metabolism]; Region: AmyA; COG0366
633149008314	active site
633149008315	catalytic site [active]
633149008316	Domain of unknown function (DUF3459); Region: DUF3459; pfam11941
633149008317	Bacterial protein of unknown function (Gcw_chp); Region: Gcw_chp; cl09901
633149008318	Ammonia permease [Inorganic ion transport and metabolism]; Region: AmtB; COG0004
633149008319	3-isopropylmalate dehydrogenase; Provisional; Region: PRK00772
633149008320	isopropylmalate isomerase small subunit; Provisional; Region: leuD; PRK01641
633149008321	Aconatase-like swivel domain of 3-isopropylmalate dehydratase and related uncharacterized proteins. 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate...; Region: IPMI_Swivel; cd01577
633149008322	substrate binding site [chemical binding]; other site
633149008323	3-isopropylmalate dehydratase large subunit; Reviewed; Region: PRK00402
633149008324	3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate; Region: IPMI; cd01583
633149008325	substrate binding site [chemical binding]; other site
633149008326	ligand binding site [chemical binding]; other site
633149008327	Isopropylmalate/homocitrate/citramalate synthases [Amino acid transport and metabolism]; Region: LeuA; COG0119
633149008328	2-isopropylmalate synthase (IPMS), N-terminal catalytic TIM barrel domain; Region: DRE_TIM_IPMS; cd07940
633149008329	active site
633149008330	catalytic residues [active]
633149008331	metal binding site [ion binding]; metal-binding site
633149008332	ACT domain; Region: ACT_5; pfam13710
633149008333	acetolactate synthase 2 catalytic subunit; Reviewed; Region: PRK08978
633149008334	Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035
633149008335	PYR/PP interface [polypeptide binding]; other site
633149008336	dimer interface [polypeptide binding]; other site
633149008337	TPP binding site [chemical binding]; other site
633149008338	Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205
633149008339	Thiamine pyrophosphate (TPP) family, Acetohydroxyacid synthase (AHAS) subfamily, TPP-binding module; composed of proteins similar to the large catalytic subunit of AHAS. AHAS catalyzes the condensation of two molecules of pyruvate to give the...; Region: TPP_AHAS; cd02015
633149008340	TPP-binding site [chemical binding]; other site
633149008341	dimer interface [polypeptide binding]; other site
633149008342	ketol-acid reductoisomerase; Provisional; Region: PRK05479
633149008343	Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvN; pfam07991
633149008344	Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvC; pfam01450
633149008345	Dehydratase family; Region: ILVD_EDD; cl00340
633149008346	Aminopeptidase N [Amino acid transport and metabolism]; Region: PepN; COG0308
633149008347	Peptidase M1 family containing bacterial Aminopeptidase N; Region: M1_APN_5; cd09604
633149008348	Zn binding site [ion binding]; other site
633149008349	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
633149008350	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
633149008351	RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730
633149008352	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
633149008353	HlyD family secretion protein; Region: HlyD_3; pfam13437
633149008354	Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841
633149008355	Outer membrane protein [Cell envelope biogenesis, outer membrane / Intracellular trafficking and secretion]; Region: TolC; COG1538
633149008356	dihydropyrimidine dehydrogenase subunit A; Provisional; Region: PRK11749
633149008357	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
633149008358	glutamate synthase subunit alpha; Provisional; Region: gltB; PRK11750
633149008359	Glutamine amidotransferases class-II (Gn-AT), glutamate synthase (GltS)-type. GltS is a homodimer that synthesizes L-glutamate from 2-oxoglutarate and L-glutamine, an important step in ammonia assimilation in bacteria, cyanobacteria and plants. The...; Region: GltS; cd00713
633149008360	active site
633149008361	dimer interface [polypeptide binding]; other site
633149008362	Glutamate synthase central domain; Region: Glu_syn_central; pfam04898
633149008363	Glutamate synthase (GltS) FMN-binding domain.  GltS is a complex iron-sulfur flavoprotein that catalyzes the reductive synthesis of L-glutamate from 2-oxoglutarate and L-glutamine via intramolecular channelling of ammonia, a reaction in the plant, yeast...; Region: GltS_FMN; cd02808
633149008364	active site
633149008365	FMN binding site [chemical binding]; other site
633149008366	substrate binding site [chemical binding]; other site
633149008367	3Fe-4S cluster binding site [ion binding]; other site
633149008368	GXGXG domain. This domain of unknown function is found at the C-terminus of the large subunit (gltB) of glutamate synthase (GltS),  in subunit C of tungsten formylmethanofuran dehydrogenase (FwdC) and in subunit C of molybdenum formylmethanofuran...; Region: GXGXG; cl00239
633149008369	domain_subunit interface; other site
633149008370	Ammonia permease [Inorganic ion transport and metabolism]; Region: AmtB; COG0004
633149008371	ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131
633149008372	ABC-type multidrug transport system, ATPase component; Region: ABC_drug_resistance_like; cd03264
633149008373	Walker A/P-loop; other site
633149008374	ATP binding site [chemical binding]; other site
633149008375	Q-loop/lid; other site
633149008376	ABC transporter signature motif; other site
633149008377	Walker B; other site
633149008378	D-loop; other site
633149008379	H-loop/switch region; other site
633149008380	ABC-2 family transporter protein; Region: ABC2_membrane_2; pfam12679
633149008381	ABC-2 family transporter protein; Region: ABC2_membrane_4; pfam12730
633149008382	Peptidase Gluzincin family (thermolysin-like proteinases, TLPs) includes peptidases M1, M2, M3, M4, M13, M32 and M36 (fungalysins); Region: GluZincin; cl14813
633149008383	Zn binding site [ion binding]; other site
633149008384	malate synthase G; Provisional; Region: PRK02999
633149008385	active site
633149008386	Carboxylesterase type B [Lipid metabolism]; Region: PnbA; COG2272
633149008387	Esterases and lipases (includes fungal lipases, cholinesterases, etc.)  These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312
633149008388	substrate binding pocket [chemical binding]; other site
633149008389	catalytic triad [active]
633149008390	Protein of unknown function (DUF1345); Region: DUF1345; pfam07077
633149008391	DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker  B motif; Region: DEADc; cd00268
633149008392	DEAD-like helicases superfamily; Region: DEXDc; smart00487
633149008393	ATP binding site [chemical binding]; other site
633149008394	Mg++ binding site [ion binding]; other site
633149008395	motif III; other site
633149008396	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
633149008397	nucleotide binding region [chemical binding]; other site
633149008398	ATP-binding site [chemical binding]; other site
633149008399	Outer membrane protein transport protein (OMPP1/FadL/TodX); Region: Toluene_X; cl17479
633149008400	Predicted nucleotide-utilizing enzyme related to molybdopterin-biosynthesis enzyme MoeA [General function prediction only]; Region: CinA; COG1058
633149008401	Competence-damaged protein. CinA is the first gene in the competence- inducible (cin) operon and is thought to be specifically required at some stage in the process of transformation. This domain is closely related to a domain, found in a variety of...; Region: cinA; cd00885
633149008402	putative MPT binding site; other site
633149008403	Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086
633149008404	active site
633149008405	hypothetical protein; Reviewed; Region: PRK00024
633149008406	Mov34/MPN/PAD-1 family; Region: MPN_DUF2466; cd08071
633149008407	MPN+ (JAMM) motif; other site
633149008408	Zinc-binding site [ion binding]; other site
633149008409	Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302
633149008410	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182
633149008411	Stress-induced morphogen (activity unknown) [Signal transduction mechanisms]; Region: BolA; COG0271
633149008412	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cl00470
633149008413	active site
633149008414	catalytic tetrad [active]
633149008415	Glutaredoxin (GRX) family, PKC-interacting cousin of TRX (PICOT)-like subfamily; composed of PICOT and GRX-PICOT-like proteins. The non-PICOT members of this family contain only the GRX-like domain, whereas PICOT contains an N-terminal TRX-like domain...; Region: GRX_PICOT_like; cd03028
633149008416	putative GSH binding site [chemical binding]; other site
633149008417	catalytic residues [active]
633149008418	4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586
633149008419	active site
633149008420	PAS domain; Region: PAS_9; pfam13426
633149008421	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920
633149008422	Histidine kinase; Region: HisKA_2; pfam07568
633149008423	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
633149008424	ATP binding site [chemical binding]; other site
633149008425	Mg2+ binding site [ion binding]; other site
633149008426	G-X-G motif; other site
633149008427	Ycf48-like protein; Provisional; Region: PRK13684
633149008428	Uncharacterized protein related to plant photosystem II stability/assembly factor [General function prediction only]; Region: COG4447
633149008429	30S ribosomal protein S4; Validated; Region: rpsD; PRK05327
633149008430	Ribosomal protein S4/S9 N-terminal domain; Region: Ribosomal_S4; pfam00163
633149008431	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
633149008432	RNA binding surface [nucleotide binding]; other site
633149008433	Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849
633149008434	Superoxide dismutase [Inorganic ion transport and metabolism]; Region: SodA; COG0605
633149008435	Iron/manganese superoxide dismutases, alpha-hairpin domain; Region: Sod_Fe_N; pfam00081
633149008436	Iron/manganese superoxide dismutases, C-terminal domain; Region: Sod_Fe_C; pfam02777
633149008437	S-formylglutathione hydrolase; Region: fghA_ester_D; TIGR02821
633149008438	S-formylglutathione hydrolase; Region: PLN02442
633149008439	This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632
633149008440	active site
633149008441	metal binding site [ion binding]; metal-binding site
633149008442	Zn-dependent alcohol dehydrogenases, class III [Energy production and conversion]; Region: AdhC; COG1062
633149008443	class III alcohol dehydrogenases; Region: alcohol_DH_class_III; cd08300
633149008444	substrate binding site [chemical binding]; other site
633149008445	catalytic Zn binding site [ion binding]; other site
633149008446	NAD binding site [chemical binding]; other site
633149008447	structural Zn binding site [ion binding]; other site
633149008448	dimer interface [polypeptide binding]; other site
633149008449	SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588
633149008450	rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: LasT; COG0565
633149008451	Zinc dependent phospholipase C/S1-P1 nuclease; Region: ZnPC_S1P1; cl16915
633149008452	Zn binding site [ion binding]; other site
633149008453	Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876
633149008454	M28 Zn-Peptidases containing a PA domain insert; Region: M28_like_PA; cd03877
633149008455	Peptidase family M28; Region: Peptidase_M28; pfam04389
633149008456	metal binding site [ion binding]; metal-binding site
633149008457	Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625
633149008458	GST_N family, unknown subfamily 4; composed of uncharacterized bacterial proteins with similarity to GSTs. GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of...; Region: GST_N_4; cd03056
633149008459	putative C-terminal domain interface [polypeptide binding]; other site
633149008460	putative GSH binding site (G-site) [chemical binding]; other site
633149008461	putative dimer interface [polypeptide binding]; other site
633149008462	C-terminal, alpha helical domain of the Glutathione S-transferase family; Region: GST_C_family; cl02776
633149008463	N-terminal domain interface [polypeptide binding]; other site
633149008464	3D domain; Region: 3D; pfam06725
633149008465	Helix-turn-helix domain; Region: HTH_18; pfam12833
633149008466	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
633149008467	C-terminal processing peptidase family S41; Region: Peptidase_S41; cl02526
633149008468	Active site serine [active]
633149008469	Protein of unknown function (DUF962); Region: DUF962; cl01879
633149008470	undecaprenyl pyrophosphate phosphatase; Reviewed; Region: PRK00281
633149008471	Citrate synthase (CS), citryl-CoA lyase (CCL), the C-terminal portion of the single-subunit type ATP-citrate lyase (ACL) and the C-terminal portion of the large subunit of the two-subunit type ACL. CS catalyzes the condensation of acetyl coenzyme A; Region: CS_ACL-C_CCL; cl00416
633149008472	oxalacetate binding site [chemical binding]; other site
633149008473	citrylCoA binding site [chemical binding]; other site
633149008474	coenzyme A binding site [chemical binding]; other site
633149008475	catalytic triad [active]
633149008476	Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053
633149008477	Cation efflux family; Region: Cation_efflux; cl00316
633149008478	Glutathione S-transferase (GST) family, N-terminal domain; a large, diverse group of cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of  glutathione (GSH) with a wide range of endogenous and xenobiotic...; Region: GST_N_family; cd00570
633149008479	Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625
633149008480	C-terminal domain interface [polypeptide binding]; other site
633149008481	GSH binding site (G-site) [chemical binding]; other site
633149008482	dimer interface [polypeptide binding]; other site
633149008483	C-terminal, alpha helical domain of the Glutathione S-transferase family; Region: GST_C_family; cd00299
633149008484	N-terminal domain interface [polypeptide binding]; other site
633149008485	dimer interface [polypeptide binding]; other site
633149008486	substrate binding pocket (H-site) [chemical binding]; other site
633149008487	epoxyqueuosine reductase; Region: TIGR00276
633149008488	Domain of unknown function (DUF1730); Region: DUF1730; pfam08331
633149008489	Domain of unknown function (DUF427); Region: DUF427; pfam04248
633149008490	ABC-2 type transporter; Region: ABC2_membrane; cl17235
633149008491	ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842
633149008492	ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131
633149008493	ATP-binding cassette domain of the lipid transporters, subfamily A; Region: ABC_subfamily_A; cd03263
633149008494	Walker A/P-loop; other site
633149008495	ATP binding site [chemical binding]; other site
633149008496	Q-loop/lid; other site
633149008497	ABC transporter signature motif; other site
633149008498	Walker B; other site
633149008499	D-loop; other site
633149008500	H-loop/switch region; other site
633149008501	Domain of Unknown Function (DUF1206); Region: DUF1206; pfam06724
633149008502	Domain of Unknown Function (DUF1206); Region: DUF1206; pfam06724
633149008503	Lipocalin-like domain; Region: Lipocalin_2; pfam08212
633149008504	Glucose/sorbosone dehydrogenases [Carbohydrate transport and metabolism]; Region: COG2133
633149008505	long-chain-acyl-CoA synthetase; Validated; Region: PRK08279
633149008506	Fatty acid transport proteins (FATP) play dual roles as fatty acid transporters and its activation enzymes; Region: FATP_FACS; cd05940
633149008507	acyl-activating enzyme (AAE) consensus motif; other site
633149008508	putative AMP binding site [chemical binding]; other site
633149008509	putative active site [active]
633149008510	putative CoA binding site [chemical binding]; other site
633149008511	Flagellar motor component [Cell motility and secretion]; Region: MotA; COG1291
633149008512	flagellar motor protein MotA; Validated; Region: PRK09110
633149008513	Uncharacterized conserved protein [Function unknown]; Region: COG4121
633149008514	tRNA U-34 5-methylaminomethyl-2-thiouridine biosynthesis protein MnmC, C-terminal domain; Region: MnmC_Cterm; TIGR03197
633149008515	methylmalonyl-CoA mutase; Reviewed; Region: PRK09426
633149008516	Coenzyme B12-dependent-methylmalonyl coenzyme A (CoA) mutase (MCM) family, Alpha subunit-like subfamily; contains proteins similar to the alpha subunit of Propionbacterium shermanni MCM, as well as human and E. coli MCM. Members of this subfamily contain...; Region: MM_CoA_mutase_alpha_like; cd03679
633149008517	active site
633149008518	substrate binding site [chemical binding]; other site
633149008519	coenzyme B12 binding site [chemical binding]; other site
633149008520	methylmalonyl CoA mutase B12 binding domain. This domain binds to B12 (adenosylcobamide), which initiates the conversion of succinyl CoA and methylmalonyl CoA by forming an adenosyl radical, which then undergoes a rearrangement exchanging a hydrogen atom...; Region: MM_CoA_mut_B12_BD; cd02071
633149008521	B12 binding site [chemical binding]; other site
633149008522	cobalt ligand [ion binding]; other site
633149008523	Coenzyme B12-dependent-methylmalonyl coenzyme A (CoA) mutase (MCM)-like family; contains proteins similar to MCM, and the large subunit of Streptomyces coenzyme B12-dependent isobutyryl-CoA mutase (ICM). MCM catalyzes the isomerization of...; Region: MM_CoA_mutase; cl00817
633149008524	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
633149008525	D-galactonate transporter; Region: 2A0114; TIGR00893
633149008526	putative substrate translocation pore; other site
633149008527	Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; cl11421
633149008528	Transcriptional regulators [Transcription]; Region: PurR; COG1609
633149008529	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
633149008530	DNA binding site [nucleotide binding]
633149008531	domain linker motif; other site
633149008532	Ligand-binding domain of DNA transcription repressor SalR, a member of the LacI-GalR family of bacterial transcription regulators; Region: PBP1_SalR; cd01545
633149008533	putative dimerization interface [polypeptide binding]; other site
633149008534	putative ligand binding site [chemical binding]; other site
633149008535	hypothetical protein; Provisional; Region: PRK09273
633149008536	Ribose 5-phosphate isomerase RpiB [Carbohydrate transport and metabolism]; Region: RpiB; COG0698
633149008537	Ribose-5-phosphate isomerase; Region: DUF3666; pfam12408
633149008538	2-deoxy-D-gluconate 3-dehydrogenase; Region: kduD; TIGR01832
633149008539	gluconate 5-dehydrogenase (Ga5DH)-like, classical (c) SDRs; Region: Ga5DH-like_SDR_c; cd05347
633149008540	NADP binding site [chemical binding]; other site
633149008541	homodimer interface [polypeptide binding]; other site
633149008542	active site
633149008543	Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524
633149008544	2-keto-3-deoxygluconate kinase (KdgK) phosphorylates 2-keto-3-deoxygluconate (KDG) to form 2-keto-3-deoxy-6-phosphogluconate (KDGP). KDG is the common intermediate product, that allows organisms to channel D-glucuronate and/or D-galacturinate into the...; Region: KdgK; cd01166
633149008545	substrate binding site [chemical binding]; other site
633149008546	ATP binding site [chemical binding]; other site
633149008547	Pectic acid lyase; Region: Pec_lyase; pfam09492
633149008548	Concanavalin A-like lectin/glucanases superfamily; Region: Laminin_G_3; pfam13385
633149008549	50S ribosomal protein L19; Provisional; Region: rplS; PRK05338
633149008550	tRNA (guanine-N(1)-)-methyltransferase; Reviewed; Region: trmD; PRK00026
633149008551	Bacterial protein of unknown function (DUF885); Region: DUF885; pfam05960
633149008552	TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947
633149008553	Thioredoxin-like; Region: Thioredoxin_8; pfam13905
633149008554	catalytic residues [active]
633149008555	double-strand break repair helicase AddA, alphaproteobacterial type; Region: addA_alphas; TIGR02784
633149008556	Part of AAA domain; Region: AAA_19; pfam13245
633149008557	Family description; Region: UvrD_C_2; pfam13538
633149008558	PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705
633149008559	double-strand break repair protein AddB, alphaproteobacterial type; Region: addB_alphas; TIGR02786
633149008560	CRISPR/Cas system-associated protein Cas4; Region: Cas4_I-A_I-B_I-C_I-D_II-B; cl00641
633149008561	Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis/translation initiation factor 2B, gamma/epsilon subunits (eIF-2Bgamma/eIF-2Bepsilon) [Cell envelope biogenesis, outer membrane / Translation, ribosomal structure...; Region: GCD1; COG1208
633149008562	NTP_transferase_like_1 is a member of the nucleotidyl transferase family; Region: NTP_transferase_like_1; cd06422
633149008563	Substrate binding site; other site
633149008564	metal-binding site
633149008565	Predicted phosphotransferase related to Ser/Thr protein kinases [General function prediction only]; Region: COG3178
633149008566	Phosphotransferase enzyme family; Region: APH; pfam01636
633149008567	Predicted ATPase or kinase [General function prediction only]; Region: COG0802
633149008568	1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204
633149008569	Lysophospholipid acyltransferases (LPLATs) of glycerophospholipid biosynthesis; Region: LPLAT; cl17185
633149008570	putative acyl-acceptor binding pocket; other site
633149008571	Dipeptidyl aminopeptidases/acylaminoacyl-peptidases [Amino acid transport and metabolism]; Region: DAP2; COG1506
633149008572	Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326
633149008573	Brown fat-inducible thioesterase (BFIT).  Brain acyl-CoA hydrolase (BACH).  These enzymes deacylate long-chain fatty acids by hydrolyzing acyl-CoA thioesters to free fatty acids and CoA-SH. Eukaryotic members of this family are expressed in brain, testis; Region: BFIT_BACH; cd03442
633149008574	Pentapeptide repeats containing protein [Function unknown]; Region: COG1357
633149008575	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
633149008576	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
633149008577	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
633149008578	Holliday junction DNA helicase RuvB; Reviewed; Region: ruvB; PRK00080
633149008579	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
633149008580	Walker A motif; other site
633149008581	ATP binding site [chemical binding]; other site
633149008582	Walker B motif; other site
633149008583	arginine finger; other site
633149008584	Holliday junction DNA helicase ruvB C-terminus; Region: RuvB_C; pfam05491
633149008585	Holliday junction DNA helicase RuvA; Reviewed; Region: ruvA; PRK00116
633149008586	RuvA N terminal domain; Region: RuvA_N; pfam01330
633149008587	RuvA, C-terminal domain; Region: RuvA_C; pfam07499
633149008588	Holliday junction resolvases (HJRs) are endonucleases that specifically resolve Holliday junction DNA intermediates during homologous recombination. HJR's occur in archaea, bacteria, and in the mitochondria of certain fungi, however this CD...; Region: RuvC_resolvase; cd00529
633149008589	active site
633149008590	putative DNA-binding cleft [nucleotide binding]; other site
633149008591	dimer interface [polypeptide binding]; other site
633149008592	hypothetical protein; Provisional; Region: PRK09133
633149008593	M20 Peptidase, carboxypeptidase yscS-like; Region: M20_yscS_like; cd05675
633149008594	putative metal binding site [ion binding]; other site
633149008595	MgtC family; Region: MgtC; pfam02308
633149008596	putative Mg(2+) transport ATPase; Provisional; Region: PRK09977
633149008597	Hemerythrin-like domain; Region: Hr-like; cd12108
633149008598	Fe binding site [ion binding]; other site
633149008599	chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168
633149008600	hypothetical protein; Validated; Region: PRK00110
633149008601	4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586
633149008602	active site
633149008603	Zn-dependent alcohol dehydrogenases, class III [Energy production and conversion]; Region: AdhC; COG1062
633149008604	Zinc-dependent alcohol dehydrogenases (ADH) and class III ADG (AKA formaldehyde dehydrogenase); Region: liver_ADH_like1; cd08281
633149008605	NAD binding site [chemical binding]; other site
633149008606	catalytic Zn binding site [ion binding]; other site
633149008607	substrate binding site [chemical binding]; other site
633149008608	structural Zn binding site [ion binding]; other site
633149008609	Domain of unknown function (DUF1993); Region: DUF1993; pfam09351
633149008610	Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524
633149008611	Ribokinase catalyses the phosphorylation of ribose to ribose-5-phosphate using ATP. This reaction is the first step in the ribose metabolism. It traps ribose within the cell after uptake and also prepares the sugar for use in the synthesis of nucleotides...; Region: ribokinase; cd01174
633149008612	substrate binding site [chemical binding]; other site
633149008613	dimer interface [polypeptide binding]; other site
633149008614	ATP binding site [chemical binding]; other site
633149008615	nuc_hydro_IU_UC_XIUA: inosine-uridine preferring, xanthosine-inosine-uridine-adenosine-preferring and, uridine-cytidine preferring nucleoside hydrolases. Nucleoside hydrolases cleave the N-glycosidic bond in nucleosides generating ribose and the...; Region: nuc_hydro_IU_UC_XIUA; cd02651
633149008616	active site
633149008617	tetramer interface [polypeptide binding]; other site
633149008618	Predicted phosphatase [General function prediction only]; Region: PhoX; COG3211
633149008619	Asp/Glu/Hydantoin racemase; Region: Asp_Glu_race; cl00518
633149008620	aspartate racemase; Region: asp_race; TIGR00035
633149008621	CHASE4 domain; Region: CHASE4; pfam05228
633149008622	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
633149008623	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
633149008624	dimer interface [polypeptide binding]; other site
633149008625	phosphorylation site [posttranslational modification]
633149008626	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
633149008627	ATP binding site [chemical binding]; other site
633149008628	Mg2+ binding site [ion binding]; other site
633149008629	G-X-G motif; other site
633149008630	Response regulator receiver domain; Region: Response_reg; pfam00072
633149008631	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
633149008632	active site
633149008633	phosphorylation site [posttranslational modification]
633149008634	intermolecular recognition site; other site
633149008635	dimerization interface [polypeptide binding]; other site
633149008636	Bacterial protein of unknown function (Gcw_chp); Region: Gcw_chp; cl09901
633149008637	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
633149008638	S-adenosylmethionine binding site [chemical binding]; other site
633149008639	Predicted methyltransferase regulatory domain; Region: MethyTransf_Reg; pfam10119
633149008640	Protein of unknown function (DUF3253); Region: DUF3253; pfam11625
633149008641	D-cysteine desulfhydrase; Validated; Region: PRK03910
633149008642	Tryptophan synthase beta superfamily (fold type II); this family of pyridoxal phosphate (PLP)-dependent enzymes catalyzes beta-replacement and beta-elimination reactions. This CD corresponds to aminocyclopropane-1-carboxylate deaminase (ACCD), tryptophan...; Region: Trp-synth-beta_II; cl00342
633149008643	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
633149008644	catalytic residue [active]
633149008645	Sensors of blue-light using FAD; Region: BLUF; pfam04940
633149008646	thiamine biosynthesis protein ThiC; Provisional; Region: PRK09284
633149008647	ThiC-associated domain; Region: ThiC-associated; pfam13667
633149008648	ThiC family; Region: ThiC; pfam01964
633149008649	TIGR03545 family protein; Region: TIGR03545
633149008650	Predicted dithiol-disulfide isomerase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: FrnE; COG2761
633149008651	DsbA family, FrnE subfamily; FrnE is a DsbA-like protein containing a CXXC motif. It is presumed to be a thiol oxidoreductase involved in polyketide biosynthesis, specifically in the production of the aromatic antibiotics frenolicin and nanaomycins; Region: DsbA_FrnE; cd03024
633149008652	catalytic residues [active]
633149008653	Domain of unknown function, appears to be related to a diverse group of endonucleases; Region: Endonuclease_DUF559; cd01038
633149008654	putative active site [active]
633149008655	methionyl-tRNA formyltransferase; Reviewed; Region: fmt; PRK00005
633149008656	Methionyl-tRNA formyltransferase, N-terminal hydrolase domain; Region: FMT_core_Met-tRNA-FMT_N; cd08646
633149008657	putative active site [active]
633149008658	substrate binding site [chemical binding]; other site
633149008659	putative cosubstrate binding site; other site
633149008660	catalytic site [active]
633149008661	C-terminal domain of Formyltransferase and other enzymes; Region: Met_tRNA_FMT_C; cd08704
633149008662	substrate binding site [chemical binding]; other site
633149008663	tRNA pseudouridine synthase A; Validated; Region: truA; PRK00021
633149008664	Eukaryotic and bacterial pseudouridine synthases similar to E.  coli TruA; Region: PseudoU_synth_EcTruA; cd02570
633149008665	dimerization interface 3.5A [polypeptide binding]; other site
633149008666	active site
633149008667	thiamine pyrophosphate protein; Validated; Region: PRK08199
633149008668	Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035
633149008669	PYR/PP interface [polypeptide binding]; other site
633149008670	dimer interface [polypeptide binding]; other site
633149008671	TPP binding site [chemical binding]; other site
633149008672	Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205
633149008673	Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cd00568
633149008674	TPP-binding site [chemical binding]; other site
633149008675	Folylpolyglutamate synthase [Coenzyme metabolism]; Region: FolC; COG0285
633149008676	Predicted membrane protein [Function unknown]; Region: COG4270
633149008677	acetyl-CoA carboxylase subunit beta; Validated; Region: PRK05654
633149008678	malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682
633149008679	Ttryptophan synthase (TRPS) alpha subunit (TSA). TPRS is a bifunctional tetrameric enzyme (2 alpha and 2 beta subunits) that catalyzes the last two steps of L-tryptophan biosynthesis. Alpha and beta subunit catalyze two distinct reactions which are both...; Region: Tryptophan_synthase_alpha; cd04724
633149008680	substrate binding site [chemical binding]; other site
633149008681	active site
633149008682	catalytic residues [active]
633149008683	heterodimer interface [polypeptide binding]; other site
633149008684	tryptophan synthase, beta subunit; Region: trpB; TIGR00263
633149008685	Tryptophan synthase-beta:  Trptophan synthase is a bifunctional enzyme that catalyses the last two steps in the biosynthesis of L-tryptophan via its alpha and beta reactions. In the alpha reaction, indole 3-glycerol phosphate is cleaved reversibly to...; Region: Trp-synth_B; cd06446
633149008686	pyridoxal 5'-phosphate binding site [chemical binding]; other site
633149008687	catalytic residue [active]
633149008688	Phosphoribosylanthranilate isomerase (PRAI) catalyzes the fourth step of the tryptophan biosynthesis, the conversion of N-(5'- phosphoribosyl)-anthranilate (PRA) to 1-(o-carboxyphenylamino)- 1-deoxyribulose 5-phosphate (CdRP). Most PRAIs are...; Region: PRAI; cd00405
633149008689	active site
633149008690	16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187
633149008691	Pseudouridine synthase, Escherichia coli RsuA like; Region: PseudoU_synth_RsuA; cd02553
633149008692	active site
633149008693	uracil binding [chemical binding]; other site
633149008694	16S RNA G1207 methylase RsmC [Translation, ribosomal structure and biogenesis]; Region: RsmC; COG2813
633149008695	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
633149008696	S-adenosylmethionine binding site [chemical binding]; other site
633149008697	putative acyltransferase; Provisional; Region: PRK05790
633149008698	Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751
633149008699	dimer interface [polypeptide binding]; other site
633149008700	active site
633149008701	Predicted membrane protein, hemolysin III homolog [General function prediction only]; Region: COG1272
633149008702	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5394
633149008703	PHB/PHA accumulation regulator DNA-binding domain; Region: PHB_acc_N; pfam07879
633149008704	PHB accumulation regulatory domain; Region: PHB_acc; pfam05233
633149008705	DPM_DPG-synthase_like is a member of the Glycosyltransferase 2 superfamily; Region: DPM_DPG-synthase_like; cd04179
633149008706	Ligand binding site; other site
633149008707	Putative Catalytic site; other site
633149008708	DXD motif; other site
633149008709	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family [Cell envelope biogenesis, outer membrane]; Region: ArnT; COG1807
633149008710	Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; cl17364
633149008711	Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; cl17364
633149008712	3-hydroxy-3-methylglutaryl-CoA lyase, catalytic TIM barrel domain; Region: DRE_TIM_HMGL; cd07938
633149008713	active site
633149008714	catalytic residues [active]
633149008715	metal binding site [ion binding]; metal-binding site
633149008716	DNA-binding transcriptional activator KdpE; Provisional; Region: PRK10529
633149008717	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
633149008718	active site
633149008719	phosphorylation site [posttranslational modification]
633149008720	intermolecular recognition site; other site
633149008721	dimerization interface [polypeptide binding]; other site
633149008722	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
633149008723	DNA binding site [nucleotide binding]
633149008724	Osmosensitive K+ channel histidine kinase [Signal transduction mechanisms]; Region: KdpD; COG2205
633149008725	Osmosensitive K+ channel His kinase sensor domain; Region: KdpD; pfam02702
633149008726	USP domain is located between the N-terminal sensor domain and C-terminal catalytic domain of this Osmosensitive K+ channel histidine kinase family. The family of KdpD sensor kinase proteins regulates the kdpFABC operon responsible for potassium...; Region: USP_OKCHK; cd01987
633149008727	Ligand Binding Site [chemical binding]; other site
633149008728	Domain of unknown function (DUF4118); Region: DUF4118; pfam13493
633149008729	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
633149008730	dimer interface [polypeptide binding]; other site
633149008731	phosphorylation site [posttranslational modification]
633149008732	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
633149008733	ATP binding site [chemical binding]; other site
633149008734	Mg2+ binding site [ion binding]; other site
633149008735	G-X-G motif; other site
633149008736	N-terminal domain of Streptomyces griseus SgaA (suppression of growth disturbance caused by A-factor at a high concentration under high osmolality during early growth phase), and similar domains; Region: SgaA_N_like; cd07247
633149008737	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
633149008738	K+-transporting ATPase, c chain [Inorganic ion transport and metabolism]; Region: KdpC; COG2156
633149008739	Bacterial protein of unknown function (Gcw_chp); Region: Gcw_chp; cl09901
633149008740	potassium-transporting ATPase subunit B; Provisional; Region: PRK01122
633149008741	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
633149008742	Soluble P-type ATPase [General function prediction only]; Region: COG4087
633149008743	potassium-transporting ATPase subunit A; Provisional; Region: PRK05482
633149008744	bifunctional proline dehydrogenase/pyrroline-5-carboxylate dehydrogenase; Reviewed; Region: PRK11904
633149008745	Proline dehydrogenase [Amino acid transport and metabolism]; Region: PutA; COG0506
633149008746	Delta(1)-pyrroline-5-carboxylate dehydrogenase, PutA; Region: ALDH_PutA-P5CDH; cd07125
633149008747	Glutamate binding site [chemical binding]; other site
633149008748	NAD binding site [chemical binding]; other site
633149008749	catalytic residues [active]
633149008750	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
633149008751	This family is most closely related to the GT1 family of glycosyltransferases. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can...; Region: GT1_like_2; cd03814
633149008752	ABC-type phosphate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: PstS; COG0226
633149008753	phosphonate ABC transporter, permease protein PhnE; Region: PhnE; TIGR01097
633149008754	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
633149008755	dimer interface [polypeptide binding]; other site
633149008756	conserved gate region; other site
633149008757	putative PBP binding loops; other site
633149008758	ABC-ATPase subunit interface; other site
633149008759	phosphonate ABC transporter, periplasmic phosphonate binding protein; Region: PhnD; TIGR03431
633149008760	ABC-type phosphate/phosphonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: COG3638
633149008761	ATP-binding cassette domain of the binding protein-dependent phosphonate transport system; Region: ABC_PhnC_transporter; cd03256
633149008762	Walker A/P-loop; other site
633149008763	ATP binding site [chemical binding]; other site
633149008764	Q-loop/lid; other site
633149008765	ABC transporter signature motif; other site
633149008766	Walker B; other site
633149008767	D-loop; other site
633149008768	H-loop/switch region; other site
633149008769	Predicted membrane protein (DUF2254); Region: DUF2254; pfam10011
633149008770	Predicted membrane protein [Function unknown]; Region: COG4325
633149008771	Diaminopimelate decarboxylase [Amino acid transport and metabolism]; Region: LysA; COG0019
633149008772	Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Ornithine Decarboxylase; Region: PLPDE_III_ODC; cd00622
633149008773	dimer interface [polypeptide binding]; other site
633149008774	active site
633149008775	pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site
633149008776	catalytic residues [active]
633149008777	substrate binding site [chemical binding]; other site
633149008778	deoxyhypusine synthase-like protein; Provisional; Region: PRK02492
633149008779	deoxyhypusine synthase; Region: dhys; TIGR00321
633149008780	Predicted transcriptional regulators [Transcription]; Region: COG1695
633149008781	Transcriptional regulator PadR-like family; Region: PadR; pfam03551
633149008782	PAP2_like proteins, a super-family of histidine phosphatases and vanadium haloperoxidases, includes type 2 phosphatidic acid phosphatase or lipid phosphate phosphatase (LPP), Glucose-6-phosphatase, Phosphatidylglycerophosphatase B and bacterial acid...; Region: PAP2_like; cl00474
633149008783	active site
633149008784	Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671
633149008785	Right handed beta helix region; Region: Beta_helix; pfam13229
633149008786	N-carbamoylputrescine amidohydrolase (CPA) (class 11 nitrilases); Region: CPA; cd07573
633149008787	N-carbamoylputrescine amidase; Region: agmatine_aguB; TIGR03381
633149008788	putative active site; other site
633149008789	catalytic triad [active]
633149008790	putative dimer interface [polypeptide binding]; other site
633149008791	Peptidylarginine deiminase and related enzymes [Amino acid transport and metabolism]; Region: COG2957; cl01113
633149008792	Porphyromonas-type peptidyl-arginine deiminase; Region: PAD_porph; pfam04371
633149008793	Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620
633149008794	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244
633149008795	Peptide methionine sulfoxide reductase; Region: PMSR; pfam01625
633149008796	Capsule polysaccharide export protein [Cell envelope biogenesis, outer membrane]; Region: KpsS; COG3562
633149008797	Capsule polysaccharide biosynthesis protein; Region: Capsule_synth; pfam05159
633149008798	Opacity protein and related surface antigens [Cell envelope biogenesis, outer membrane]; Region: COG3637
633149008799	Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885
633149008800	Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185
633149008801	ligand binding site [chemical binding]; other site
633149008802	UDP-N-acetyl-D-glucosamine 2-epimerase, UDP-hydrolysing; Region: NeuC_NnaA; TIGR03568
633149008803	Bacterial members of the UDP-N-Acetylglucosamine (GlcNAc) 2-Epimerase  family are known to catalyze the reversible interconversion of UDP-GlcNAc and UDP-N-acetylmannosamine (UDP-ManNAc). The enzyme serves to produce an activated form of ManNAc residues; Region: GT1_UDP-GlcNAc_2-Epimerase; cd03786
633149008804	active site
633149008805	homodimer interface [polypeptide binding]; other site
633149008806	CMP-NeuAc_Synthase activates N-acetylneuraminic acid by adding CMP moiety; Region: CMP-NeuAc_Synthase; cd02513
633149008807	ligand binding site; other site
633149008808	tetramer interface; other site
633149008809	Arna decarboxylase_like, extended (e) SDRs; Region: Arna_like_SDR_e; cd05257
633149008810	NAD dependent epimerase/dehydratase, LLPSF_EDH_00030 family; Region: EDH_00030; TIGR04180
633149008811	NAD binding site [chemical binding]; other site
633149008812	substrate binding site [chemical binding]; other site
633149008813	active site
633149008814	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domain associated with the NTP (Nucleotidyl transferase) domain downstream. CBS is a small domain originally identified in cystathionine beta-synthase and subsequently...; Region: CBS_pair_NTP_transferase_assoc; cd04607
633149008815	Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis/translation initiation factor 2B, gamma/epsilon subunits (eIF-2Bgamma/eIF-2Bepsilon) [Cell envelope biogenesis, outer membrane / Translation, ribosomal structure...; Region: GCD1; COG1208
633149008816	NTP_trnasferase_like_2 is a member of the nucleotidyl transferase family; Region: NTP_transferase_like_2; cd06426
633149008817	Substrate binding site; other site
633149008818	metal-binding site
633149008819	This family is most closely related to the GT1 family of glycosyltransferases. mtfB (mannosyltransferase B) in E. coli has been shown to direct the growth of the O9-specific polysaccharide chain. It transfers two mannoses into the position 3 of the...; Region: GT1_mtfB_like; cd03809
633149008820	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
633149008821	ABC-type protease/lipase transport system, ATPase and permease components [General function prediction only]; Region: ArpD; COG4618
633149008822	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
633149008823	Walker A/P-loop; other site
633149008824	ATP binding site [chemical binding]; other site
633149008825	Q-loop/lid; other site
633149008826	ABC transporter signature motif; other site
633149008827	Walker B; other site
633149008828	D-loop; other site
633149008829	H-loop/switch region; other site
633149008830	type I secretion membrane fusion protein, HlyD family; Region: type_I_hlyD; TIGR01843
633149008831	Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849
633149008832	E3 interaction surface; other site
633149008833	HlyD family secretion protein; Region: HlyD_3; pfam13437
633149008834	Mannose-1-phosphate guanylyltransferase [Cell envelope biogenesis, outer membrane]; Region: {ManC}; COG0836
633149008835	GDP-M1P_Guanylyltransferase catalyzes the formation of GDP-Mannose; Region: GDP-M1P_Guanylyltransferase; cd02509
633149008836	Substrate binding site; other site
633149008837	Cupin domain; Region: Cupin_2; cl17218
633149008838	AGE domain; N-acyl-D-glucosamine 2-epimerase domain; Responsible for intermediate epimerization during biosynthesis of N-acetylneuraminic acid. Catalytic mechanism is believed to be via nucleotide elimination and readdition and is ATP modulated. AGE is...; Region: AGE; cl00183
633149008839	dimerization interface [polypeptide binding]; other site
633149008840	putative active cleft [active]
633149008841	Zinc-dependent metalloprotease, serralysin_like subfamily. Serralysins and related proteases are important virulence factors in pathogenic bacteria. They may be secreted into the medium via a mechanism found in gram-negative bacteria, that does not...; Region: ZnMc_serralysin_like; cd04277
633149008842	active site
633149008843	Bacterial pre-peptidase C-terminal domain; Region: PPC; pfam04151
633149008844	RTX toxins and related Ca2+-binding proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2931
633149008845	ABC-2 type transporter; Region: ABC2_membrane; pfam01061
633149008846	Chain length determinant protein; Region: Wzz; cl15801
633149008847	polysaccharide export inner-membrane protein, BexC/CtrB/KpsE family; Region: BexC_CtrB_KpsE; TIGR01010
633149008848	ABC-type polysaccharide/polyol phosphate transport system, ATPase component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagH; COG1134
633149008849	ATP-binding cassette component of polysaccharide transport system; Region: ABC_KpsT_Wzt; cd03220
633149008850	Walker A/P-loop; other site
633149008851	ATP binding site [chemical binding]; other site
633149008852	Q-loop/lid; other site
633149008853	ABC transporter signature motif; other site
633149008854	Walker B; other site
633149008855	D-loop; other site
633149008856	H-loop/switch region; other site
633149008857	GDP-D-mannose dehydratase [Cell envelope biogenesis, outer membrane]; Region: Gmd; COG1089
633149008858	GDP-mannose 4,6 dehydratase, extended (e) SDRs; Region: GDP_MD_SDR_e; cd05260
633149008859	NADP-binding site; other site
633149008860	homotetramer interface [polypeptide binding]; other site
633149008861	substrate binding site [chemical binding]; other site
633149008862	homodimer interface [polypeptide binding]; other site
633149008863	active site
633149008864	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
633149008865	NAD dependent epimerase/dehydratase family; Region: Epimerase; pfam01370
633149008866	NAD(P) binding site [chemical binding]; other site
633149008867	active site
633149008868	Domain of unknown function (DUF4214); Region: DUF4214; pfam13946
633149008869	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013
633149008870	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
633149008871	This family is most closely related to the GT1 family of glycosyltransferases. mtfB (mannosyltransferase B) in E. coli has been shown to direct the growth of the O9-specific polysaccharide chain. It transfers two mannoses into the position 3 of the...; Region: GT1_mtfB_like; cd03809
633149008872	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
633149008873	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013
633149008874	Putative zinc binding domain; Region: Methyltransf_13; pfam08421
633149008875	Methyltransferase domain; Region: Methyltransf_23; pfam13489
633149008876	C-methyltransferase C-terminal domain; Region: Methyltransf_14; pfam08484
633149008877	methyltransferase, FkbM family; Region: fkbM_fam; TIGR01444
633149008878	methyltransferase, FkbM family; Region: fkbM_fam; TIGR01444
633149008879	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
633149008880	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013
633149008881	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173
633149008882	Methyltransferase domain; Region: Methyltransf_11; pfam08241
633149008883	methyltransferase, FkbM family; Region: fkbM_fam; TIGR01444
633149008884	Methyltransferase domain; Region: Methyltransf_11; pfam08241
633149008885	Putative capsular polysaccharide synthesis protein; Region: NKWYS; pfam10364
633149008886	AAK_NAGK-C: N-Acetyl-L-glutamate kinase - cyclic (NAGK-C) catalyzes the phosphorylation of the gamma-COOH group of N-acetyl-L-glutamate (NAG) by ATP in the second step of arginine biosynthesis found in some bacteria and photosynthetic organisms using the...; Region: AAK_NAGK-C; cd04250
633149008887	feedback inhibition sensing region; other site
633149008888	homohexameric interface [polypeptide binding]; other site
633149008889	nucleotide binding site [chemical binding]; other site
633149008890	N-acetyl-L-glutamate binding site [chemical binding]; other site
633149008891	pyrimidine 5'-nucleotidase; Region: Pyr-5-nucltdase; TIGR01993
633149008892	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
633149008893	motif II; other site
633149008894	2,3,4,5-tetrahydropyridine-2,6-carboxylate N-succinyltransferase; Provisional; Region: dapD; PRK11830
633149008895	2,3,4,5-tetrahydropyridine-2,6-dicarboxylate (THDP) N-succinyltransferase (also called THP succinyltransferase): THDP N-succinyltransferase catalyzes the conversion of tetrahydrodipicolinate and succinyl-CoA to N-succinyltetrahydrodipicolinate and CoA; Region: LbH_THP_succinylT; cd03350
633149008896	trimer interface [polypeptide binding]; other site
633149008897	active site
633149008898	substrate binding site [chemical binding]; other site
633149008899	CoA binding site [chemical binding]; other site
633149008900	putative polysaccharide export protein, PEP-CTERM sytem-associated; Region: pepcterm_export; TIGR03027
633149008901	Polysaccharide biosynthesis/export protein; Region: Poly_export; pfam02563
633149008902	ATP-dependent DNA helicase RecQ; Region: recQ; TIGR01389
633149008903	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
633149008904	ATP binding site [chemical binding]; other site
633149008905	putative Mg++ binding site [ion binding]; other site
633149008906	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
633149008907	nucleotide binding region [chemical binding]; other site
633149008908	ATP-binding site [chemical binding]; other site
633149008909	This DNA-binding domain is found in the RecQ helicase among others and has a helix-turn-helix structure; Region: RQC; smart00956
633149008910	HRDC domain; Region: HRDC; pfam00570
633149008911	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
633149008912	active site
633149008913	zinc-ribbon domain; Region: zinc_ribbon_4; pfam13717
633149008914	Protein of unknown function (DUF3426); Region: DUF3426; pfam11906
633149008915	cell division ATP-binding protein FtsE; Region: FtsE; TIGR02673
633149008916	ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255
633149008917	Walker A/P-loop; other site
633149008918	ATP binding site [chemical binding]; other site
633149008919	Q-loop/lid; other site
633149008920	ABC transporter signature motif; other site
633149008921	Walker B; other site
633149008922	D-loop; other site
633149008923	H-loop/switch region; other site
633149008924	Cell division protein [Cell division and chromosome partitioning]; Region: FtsX; COG2177
633149008925	Uncharacterized conserved protein [Function unknown]; Region: COG1434
633149008926	YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259
633149008927	putative active site [active]
633149008928	1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204
633149008929	Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989
633149008930	putative acyl-acceptor binding pocket; other site
633149008931	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
633149008932	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
633149008933	Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cl00220
633149008934	catalytic triad [active]
633149008935	conserved cis-peptide bond; other site
633149008936	histidinol-phosphate aminotransferase; Validated; Region: PRK02731
633149008937	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
633149008938	pyridoxal 5'-phosphate binding site [chemical binding]; other site
633149008939	homodimer interface [polypeptide binding]; other site
633149008940	catalytic residue [active]
633149008941	hypothetical protein; Provisional; Region: PRK06034
633149008942	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4093
633149008943	Uncharacterized protein conserved in bacteria (DUF2125); Region: DUF2125; pfam09898
633149008944	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4102
633149008945	Protein of unknown function (DUF1800); Region: DUF1800; pfam08811
633149008946	Rad3-related DNA helicases [Transcription / DNA replication, recombination, and repair]; Region: DinG; COG1199
633149008947	Helicase C-terminal domain; Region: Helicase_C_2; pfam13307
633149008948	DEXH box helicase, DNA ligase-associated; Region: DEXH_lig_assoc; TIGR04121
633149008949	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
633149008950	ATP binding site [chemical binding]; other site
633149008951	putative Mg++ binding site [ion binding]; other site
633149008952	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
633149008953	nucleotide binding region [chemical binding]; other site
633149008954	ATP-binding site [chemical binding]; other site
633149008955	DEAD/H associated; Region: DEAD_assoc; pfam08494
633149008956	Pyrococcus furiosus PF1019 and related proteins, metallophosphatase domain; Region: MPP_PF1019; cd07391
633149008957	Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149
633149008958	putative active site [active]
633149008959	putative metal binding site [ion binding]; other site
633149008960	Protein of unknown function (DUF3429); Region: DUF3429; pfam11911
633149008961	Putative transmembrane protein (Alph_Pro_TM); Region: Alph_Pro_TM; pfam09608
633149008962	Sulfite exporter TauE/SafE; Region: TauE; pfam01925
633149008963	FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790
633149008964	Sel1-like repeats; Region: SEL1; smart00671
633149008965	Sel1-like repeats; Region: SEL1; smart00671
633149008966	Uncharacterized stress protein (general stress protein 26) [General function prediction only]; Region: COG3871
633149008967	Pyridoxine 5'-phosphate (PNP) oxidase-like proteins; Region: PNPOx_like; cl00381
633149008968	ornithine carbamoyltransferase; Provisional; Region: PRK00779
633149008969	Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729
633149008970	Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185
633149008971	GxxExxY protein; Region: GxxExxY; TIGR04256
633149008972	acetylornithine transaminase protein; Provisional; Region: argD; PRK01278
633149008973	Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610
633149008974	inhibitor-cofactor binding pocket; inhibition site
633149008975	pyridoxal 5'-phosphate binding site [chemical binding]; other site
633149008976	catalytic residue [active]
633149008977	ABC-2 type transporter; Region: ABC2_membrane; cl17235
633149008978	ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842
633149008979	dihydrolipoamide dehydrogenase; Validated; Region: PRK05976
633149008980	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
633149008981	Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852
633149008982	Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849
633149008983	E3 interaction surface; other site
633149008984	lipoyl attachment site [posttranslational modification]; other site
633149008985	branched-chain alpha-keto acid dehydrogenase subunit E2; Reviewed; Region: PRK11856
633149008986	Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849
633149008987	E3 interaction surface; other site
633149008988	lipoyl attachment site [posttranslational modification]; other site
633149008989	e3 binding domain; Region: E3_binding; pfam02817
633149008990	2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198
633149008991	Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit [Energy production and conversion]; Region: AcoB; COG0022
633149008992	Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036
633149008993	alpha subunit interface [polypeptide binding]; other site
633149008994	TPP binding site [chemical binding]; other site
633149008995	heterodimer interface [polypeptide binding]; other site
633149008996	Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780
633149008997	2-oxoisovalerate dehydrogenase E1 alpha subunit N terminal; Region: OxoDH_E1alpha_N; pfam12573
633149008998	Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, alpha subunit [Energy production and conversion]; Region: AcoA; COG1071
633149008999	Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000
633149009000	tetramer interface [polypeptide binding]; other site
633149009001	TPP-binding site [chemical binding]; other site
633149009002	heterodimer interface [polypeptide binding]; other site
633149009003	phosphorylation loop region [posttranslational modification]
633149009004	Transcriptional regulators [Transcription]; Region: Lrp; COG1522
633149009005	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
633149009006	putative DNA binding site [nucleotide binding]; other site
633149009007	putative Zn2+ binding site [ion binding]; other site
633149009008	AsnC family; Region: AsnC_trans_reg; pfam01037
633149009009	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
633149009010	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
633149009011	non-specific DNA binding site [nucleotide binding]; other site
633149009012	salt bridge; other site
633149009013	sequence-specific DNA binding site [nucleotide binding]; other site
633149009014	enoyl-CoA hydratase; Provisional; Region: PRK05862
633149009015	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
633149009016	substrate binding site [chemical binding]; other site
633149009017	oxyanion hole (OAH) forming residues; other site
633149009018	trimer interface [polypeptide binding]; other site
633149009019	30S ribosomal protein S20; Reviewed; Region: rpsT; PRK00239