-- dump date   	20140619_010253
-- class       	Genbank::misc_feature
-- table       	misc_feature_note
-- id	note
430066000001	RNA element found in p42d and related plasmids; BAbS19_IIr0002
430066000002	replication initiation protein RepC; Provisional; Region: PRK13824
430066000003	Replication protein C N-terminal domain; Region: RP-C; pfam03428
430066000004	Replication protein C C-terminal region; Region: RP-C_C; pfam11800
430066000005	Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524
430066000006	Ribokinase catalyses the phosphorylation of ribose to ribose-5-phosphate using ATP. This reaction is the first step in the ribose metabolism. It traps ribose within the cell after uptake and also prepares the sugar for use in the synthesis of nucleotides...; Region: ribokinase; cd01174
430066000007	substrate binding site [chemical binding]; other site
430066000008	dimer interface [polypeptide binding]; other site
430066000009	ATP binding site [chemical binding]; other site
430066000010	nuc_hydro_IU_UC_XIUA: inosine-uridine preferring, xanthosine-inosine-uridine-adenosine-preferring and, uridine-cytidine preferring nucleoside hydrolases. Nucleoside hydrolases cleave the N-glycosidic bond in nucleosides generating ribose and the...; Region: nuc_hydro_IU_UC_XIUA; cd02651
430066000011	active site
430066000012	tetramer interface [polypeptide binding]; other site
430066000013	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
430066000014	Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette; Region: TM_PBP1_transp_TpRbsC_like; cd06580
430066000015	TM-ABC transporter signature motif; other site
430066000016	ABC-type uncharacterized transport systems, ATPase components [General function prediction only]; Region: COG3845
430066000017	First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216
430066000018	Q-loop/lid; other site
430066000019	ABC transporter signature motif; other site
430066000020	Walker B; other site
430066000021	D-loop; other site
430066000022	H-loop/switch region; other site
430066000023	Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215
430066000024	Uncharacterized ABC-type transport system, periplasmic component/surface lipoprotein [General function prediction only]; Region: Med; COG1744
430066000025	Periplasmic binding domain of basic membrane lipoprotein, PnrA, in Treponema pallidum and its homologs from other bacteria and Archaea; Region: PBP1_BmpA_PnrA_like; cd06354
430066000026	ligand binding site [chemical binding]; other site
430066000027	Predicted secreted Zn-dependent protease [Posttranslational modification, protein turnover, chaperones]; Region: COG5664
430066000028	Phosphopantetheinyl transferase component of siderophore synthetase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntD; COG2977
430066000029	4'-phosphopantetheinyl transferase superfamily; Region: ACPS; pfam01648
430066000030	2,3-dihydroxybenzoate-2,3-dehydrogenase; Validated; Region: PRK08220
430066000031	2,3 dihydro-2,3 dihydrozybenzoate dehydrogenases, classical (c) SDRs; Region: DH-DHB-DH_SDR_c; cd05331
430066000032	putative NAD(P) binding site [chemical binding]; other site
430066000033	active site
430066000034	Isochorismatase, also known as 2,3 dihydro-2,3 dihydroxybenzoate synthase, catalyses the conversion of isochorismate, in the presence of water, to 2,3-dihydroxybenzoate and pyruvate, via the hydrolysis of a vinyl ether, an uncommon reaction in biological...; Region: isochorismatase; cd01013
430066000035	hydrophobic substrate binding pocket; other site
430066000036	Isochorismatase family; Region: Isochorismatase; pfam00857
430066000037	active site
430066000038	conserved cis-peptide bond; other site
430066000039	Aryl carrier domain [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3433
430066000040	enterobactin synthase subunit E; Provisional; Region: entE; PRK10946
430066000041	2,3-dihydroxybenzoate-AMP ligase; Region: 23DHB-AMP_lg; cd05920
430066000042	acyl-activating enzyme (AAE) consensus motif; other site
430066000043	active site
430066000044	AMP binding site [chemical binding]; other site
430066000045	substrate binding site [chemical binding]; other site
430066000046	Isochorismate synthase [Coenzyme metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: MenF; COG1169
430066000047	isochorismate synthases; Region: isochor_syn; TIGR00543
430066000048	Condensation domain; Region: Condensation; pfam00668
430066000049	Sulfite oxidase and related enzymes [General function prediction only]; Region: COG2041
430066000050	bacterial subgroup of the sulfite oxidase (SO) family of molybdopterin binding domains. This domain is found in a variety of oxidoreductases. Common features of all known members of this family, like sulfite oxidase and nitrite reductase, are that they...; Region: bact_SO_family_Moco; cd02108
430066000051	Moco binding site; other site
430066000052	metal coordination site [ion binding]; other site
430066000053	Thiosulfate reductase cytochrome B subunit (membrane anchoring protein) [Energy production and conversion]; Region: COG4117
430066000054	Cytochrome b(N-terminal)/b6/petB; Region: Cytochrom_B_N; pfam00033
430066000055	pentapeptide MXKDX repeat protein; Region: penta_MxKDx; TIGR02953
430066000056	RNA polymerase sigma factor; Provisional; Region: PRK12539
430066000057	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
430066000058	Sigma-70, region 4; Region: Sigma70_r4_2; pfam08281
430066000059	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4944
430066000060	Transcriptional regulators [Transcription]; Region: FadR; COG2186
430066000061	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
430066000062	DNA-binding site [nucleotide binding]; DNA binding site
430066000063	This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895
430066000064	Periplasmic binding protein; Region: Peripla_BP_6; pfam13458
430066000065	Periplasmic solute-binding domain of active transport proteins; Region: PBP1_SBP_like_3; cd06329
430066000066	putative ligand binding site [chemical binding]; other site
430066000067	Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582
430066000068	TM-ABC transporter signature motif; other site
430066000069	ABC-type branched-chain amino acid transport system, permease component [Amino acid transport and metabolism]; Region: LivM; COG4177
430066000070	Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581
430066000071	TM-ABC transporter signature motif; other site
430066000072	ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411
430066000073	ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219
430066000074	Walker A/P-loop; other site
430066000075	ATP binding site [chemical binding]; other site
430066000076	Q-loop/lid; other site
430066000077	ABC transporter signature motif; other site
430066000078	Walker B; other site
430066000079	D-loop; other site
430066000080	H-loop/switch region; other site
430066000081	ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410
430066000082	ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224
430066000083	Walker A/P-loop; other site
430066000084	ATP binding site [chemical binding]; other site
430066000085	Q-loop/lid; other site
430066000086	ABC transporter signature motif; other site
430066000087	Walker B; other site
430066000088	D-loop; other site
430066000089	H-loop/switch region; other site
430066000090	This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587
430066000091	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
430066000092	active site
430066000093	3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653
430066000094	classical (c) SDRs; Region: SDR_c; cd05233
430066000095	NAD(P) binding site [chemical binding]; other site
430066000096	active site
430066000097	classical (c) SDRs; Region: SDR_c; cd05233
430066000098	NAD(P) binding site [chemical binding]; other site
430066000099	active site
430066000100	Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, alpha subunit [Energy production and conversion]; Region: AcoA; COG1071
430066000101	Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000
430066000102	tetramer interface [polypeptide binding]; other site
430066000103	TPP-binding site [chemical binding]; other site
430066000104	heterodimer interface [polypeptide binding]; other site
430066000105	phosphorylation loop region [posttranslational modification]
430066000106	Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit [Energy production and conversion]; Region: AcoB; COG0022
430066000107	Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036
430066000108	alpha subunit interface [polypeptide binding]; other site
430066000109	TPP binding site [chemical binding]; other site
430066000110	heterodimer interface [polypeptide binding]; other site
430066000111	Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780
430066000112	branched-chain alpha-keto acid dehydrogenase subunit E2; Reviewed; Region: PRK11856
430066000113	Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849
430066000114	E3 interaction surface; other site
430066000115	lipoyl attachment site [posttranslational modification]; other site
430066000116	e3 binding domain; Region: E3_binding; pfam02817
430066000117	2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198
430066000118	Shikimate 5-dehydrogenase [Amino acid transport and metabolism]; Region: AroE; COG0169
430066000119	Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501
430066000120	NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065
430066000121	shikimate binding site; other site
430066000122	NAD(P) binding site [chemical binding]; other site
430066000123	magnesium-transporting ATPase; Provisional; Region: PRK15122
430066000124	Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; smart00831
430066000125	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
430066000126	Soluble P-type ATPase [General function prediction only]; Region: COG4087
430066000127	Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689
430066000128	Uncharacterized membrane protein [Function unknown]; Region: SapB; COG1285
430066000129	MgtC family; Region: MgtC; pfam02308
430066000130	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
430066000131	ATP binding site [chemical binding]; other site
430066000132	Mg2+ binding site [ion binding]; other site
430066000133	G-X-G motif; other site
430066000134	Response regulator [Signal transduction mechanisms]; Region: TtrR; COG4566
430066000135	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
430066000136	active site
430066000137	phosphorylation site [posttranslational modification]
430066000138	intermolecular recognition site; other site
430066000139	dimerization interface [polypeptide binding]; other site
430066000140	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
430066000141	dimerization interface [polypeptide binding]; other site
430066000142	DNA binding residues [nucleotide binding]
430066000143	Response regulator receiver domain; Region: Response_reg; pfam00072
430066000144	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
430066000145	active site
430066000146	phosphorylation site [posttranslational modification]
430066000147	intermolecular recognition site; other site
430066000148	dimerization interface [polypeptide binding]; other site
430066000149	N-formylglutamate amidohydrolase [Amino acid transport and metabolism]; Region: HutG; COG3741
430066000150	Predominantly bacterial family of Mg++ dependend phosphatases, related to inositol monophosphatases. These enzymes may dephosphorylate fructose-1,6-bisphosphate, inositol monophospate, 3'-phosphoadenosine-5'-phosphate,  or similar substrates; Region: Bacterial_IMPase_like_1; cd01641
430066000151	Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483
430066000152	active site
430066000153	Lysophospholipase [Lipid metabolism]; Region: PldB; COG2267
430066000154	Putative lysophospholipase; Region: Hydrolase_4; pfam12146
430066000155	Peptidase propeptide and YPEB domain; Region: PepSY_2; pfam13670
430066000156	Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071
430066000157	Alpha-crystallin domain (ACD) found in Escherichia coli inclusion body-associated proteins IbpA and IbpB, and similar proteins.  IbpA and IbpB are 16 kDa small heat shock proteins (sHsps). sHsps are molecular chaperones that suppress protein aggregation...; Region: ACD_IbpA-B_like; cd06470
430066000158	putative dimer interface [polypeptide binding]; other site
430066000159	Threonine aldolase [Amino acid transport and metabolism]; Region: GLY1; COG2008
430066000160	Low-specificity threonine aldolase (TA). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I).  TA catalyzes the conversion of L-threonine or L-allo-threonine to glycine and acetaldehyde in a...; Region: TA_like; cd06502
430066000161	tetramer interface [polypeptide binding]; other site
430066000162	pyridoxal 5'-phosphate binding site [chemical binding]; other site
430066000163	catalytic residue [active]
430066000164	glutamate synthase subunit alpha; Provisional; Region: gltB; PRK11750
430066000165	Glutamine amidotransferases class-II (Gn-AT), glutamate synthase (GltS)-type. GltS is a homodimer that synthesizes L-glutamate from 2-oxoglutarate and L-glutamine, an important step in ammonia assimilation in bacteria, cyanobacteria and plants. The...; Region: GltS; cd00713
430066000166	active site
430066000167	dimer interface [polypeptide binding]; other site
430066000168	Glutamate synthase central domain; Region: Glu_syn_central; pfam04898
430066000169	Glutamate synthase (GltS) FMN-binding domain.  GltS is a complex iron-sulfur flavoprotein that catalyzes the reductive synthesis of L-glutamate from 2-oxoglutarate and L-glutamine via intramolecular channelling of ammonia, a reaction in the plant, yeast...; Region: GltS_FMN; cd02808
430066000170	active site
430066000171	FMN binding site [chemical binding]; other site
430066000172	substrate binding site [chemical binding]; other site
430066000173	3Fe-4S cluster binding site [ion binding]; other site
430066000174	gltb_C. This domain is found at the C-terminus of the large subunit (gltB) of glutamate synthase (GltS). GltS encodes a complex iron-sulfur flavoprotein that catalyzes the synthesis of L-glutamate from L-glutamine and 2-oxoglutarate. It requires the...; Region: gltB_C; cd00982
430066000175	domain interface; other site
430066000176	glutamate synthase subunit beta; Reviewed; Region: gltD; PRK12810
430066000177	SGNH_peri2; putative periplasmic member of the SGNH-family of hydrolases, a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known...; Region: SGNH_hydrolase_peri2; cd01829
430066000178	active site
430066000179	catalytic triad [active]
430066000180	oxyanion hole [active]
430066000181	Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885
430066000182	Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185
430066000183	ligand binding site [chemical binding]; other site
430066000184	P-type DNA transfer ATPase VirB11; Region: VirB11; TIGR02788
430066000185	Type IV secretory pathway component VirB11, and related ATPases. The homohexamer, VirB11 is one of eleven Vir proteins, which are required for T-pilus biogenesis and virulence in the transfer of T-DNA from the Ti (tumor-inducing) plasmid of bacterial to...; Region: VirB11-like_ATPase; cd01130
430066000186	ATP binding site [chemical binding]; other site
430066000187	Walker A motif; other site
430066000188	hexamer interface [polypeptide binding]; other site
430066000189	Walker B motif; other site
430066000190	Type IV secretory pathway, VirB10 components [Intracellular trafficking and secretion]; Region: VirB10; COG2948
430066000191	VirB9/CagX/TrbG, a component of the type IV secretion system; Region: VirB9_CagX_TrbG; cl11423
430066000192	VirB9/CagX/TrbG, a component of the type IV secretion system; Region: VirB9_CagX_TrbG; cd06911
430066000193	VirB7 interaction site; other site
430066000194	Type IV secretory pathway, component VirB8 [Intracellular trafficking and secretion]; Region: VirB8; COG3736
430066000195	Prokaryotic membrane lipoprotein lipid attachment site; Region: LPAM_1; pfam08139
430066000196	Type IV secretory pathway, VirB6 components [Intracellular trafficking and secretion]; Region: VirB6; COG3704
430066000197	P-type DNA transfer protein VirB5; Region: VirB5; TIGR02791
430066000198	Type IV secretion system proteins; Region: T4SS; pfam07996
430066000199	Type IV secretory pathway, VirB4 components [Intracellular trafficking and secretion]; Region: VirB4; COG3451
430066000200	CagE, TrbE, VirB family, component of type IV transporter system; Region: CagE_TrbE_VirB; pfam03135
430066000201	Type IV secretory pathway, VirB3 components [Intracellular trafficking and secretion]; Region: VirB3; COG3702
430066000202	TrbC/VIRB2 family; Region: TrbC; pfam04956
430066000203	Lytic Transglycosylase (LT)  and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL).  LTs...; Region: LT_GEWL; cd00254
430066000204	N-acetyl-D-glucosamine binding site [chemical binding]; other site
430066000205	catalytic residue [active]
430066000206	lytic murein transglycosylase; Region: MltB_2; TIGR02283
430066000207	Lytic Transglycosylase (LT)  and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL).  LTs...; Region: LT_GEWL; cd00254
430066000208	N-acetyl-D-glucosamine binding site [chemical binding]; other site
430066000209	Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471
430066000210	Prokaryotic UGPase catalyses the synthesis of UDP-glucose; Region: UGPase_prokaryotic; cd02541
430066000211	active site
430066000212	tetramer interface; other site
430066000213	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5338
430066000214	Uncharacterized protein conserved in bacteria (DUF2320); Region: DUF2320; pfam10082
430066000215	D-arabinose 5-phosphate isomerase; Provisional; Region: PRK10892
430066000216	KpsF-like protein. KpsF is an arabinose-5-phosphate isomerase which contains SIS (Sugar ISomerase) domains. SIS domains are found in many phosphosugar isomerases and phosphosugar binding proteins. KpsF catalyzes the reversible reaction of ribulose...; Region: SIS_Kpsf; cd05014
430066000217	putative active site [active]
430066000218	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with KpsF/GutQ domains in the API [A5P (D-arabinose 5-phosphate) isomerase] protein.  These APIs catalyze the conversion of the pentose pathway...; Region: CBS_pair_KpsF_GutQ_assoc; cd04604
430066000219	Membrane protein implicated in regulation of membrane protease activity [Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: COG1585
430066000220	Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330
430066000221	Band_7_stomatin_like: A subgroup of the band 7 domain of flotillin (reggie) like proteins similar to stomatin and podicin (two lipid raft-associated integral membrane proteins). Individual proteins of this band 7 domain family may cluster to form...; Region: Band_7_stomatin_like; cd03403
430066000222	ferrochelatase; Reviewed; Region: hemH; PRK00035
430066000223	Ferrochelatase, N-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_N; cd03411
430066000224	C-terminal domain interface [polypeptide binding]; other site
430066000225	active site
430066000226	Ferrochelatase, C-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_C; cd00419
430066000227	active site
430066000228	N-terminal domain interface [polypeptide binding]; other site
430066000229	Homospermidine synthase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG5310
430066000230	Saccharopine dehydrogenase; Region: Saccharop_dh; pfam03435
430066000231	hypothetical protein; Provisional; Region: PRK07546
430066000232	Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115
430066000233	substrate-cofactor binding pocket; other site
430066000234	pyridoxal 5'-phosphate binding site [chemical binding]; other site
430066000235	homodimer interface [polypeptide binding]; other site
430066000236	catalytic residue [active]
430066000237	aminodeoxychorismate synthase; Provisional; Region: PRK07508
430066000238	chorismate binding enzyme; Region: Chorismate_bind; cl10555
430066000239	oligoendopeptidase, pepF/M3 family; Region: M3_fam_3; TIGR02290
430066000240	Peptidase family M3B Oligopeptidase F (PepF); Region: M3B_PepF_5; cd09610
430066000241	active site
430066000242	Zn binding site [ion binding]; other site
430066000243	Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204
430066000244	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
430066000245	active site
430066000246	phosphorylation site [posttranslational modification]
430066000247	intermolecular recognition site; other site
430066000248	dimerization interface [polypeptide binding]; other site
430066000249	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
430066000250	Walker A motif; other site
430066000251	ATP binding site [chemical binding]; other site
430066000252	Walker B motif; other site
430066000253	Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954
430066000254	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3108
430066000255	Bacterial protein of unknown function (DUF882); Region: Peptidase_M15_2; pfam05951
430066000256	2-keto-3-deoxy-6-phosphogluconate aldolase [Carbohydrate transport and metabolism]; Region: Eda; COG0800
430066000257	KDPG and KHG aldolase; Region: KDPG_aldolase; cd00452
430066000258	active site
430066000259	intersubunit interface [polypeptide binding]; other site
430066000260	catalytic residue [active]
430066000261	Protein of unknown function (DUF3380); Region: DUF3380; pfam11860
430066000262	Predicted sulfurtransferase [General function prediction only]; Region: COG1054
430066000263	Member of the Rhodanese Homology Domain superfamily. This CD includes Escherichia coli YceA, Bacillus subtilis YbfQ, and similar uncharacterized proteins; Region: RHOD_YceA; cd01518
430066000264	active site residue [active]
430066000265	ABC-type molybdate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: ModA; COG0725
430066000266	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199
430066000267	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
430066000268	dimer interface [polypeptide binding]; other site
430066000269	conserved gate region; other site
430066000270	putative PBP binding loops; other site
430066000271	ABC-ATPase subunit interface; other site
430066000272	ABC-type molybdate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: ModC; COG4148
430066000273	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
430066000274	Walker A/P-loop; other site
430066000275	ATP binding site [chemical binding]; other site
430066000276	Q-loop/lid; other site
430066000277	ABC transporter signature motif; other site
430066000278	Walker B; other site
430066000279	D-loop; other site
430066000280	H-loop/switch region; other site
430066000281	TOBE domain; Region: TOBE; cl01440
430066000282	Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670
430066000283	ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG2215
430066000284	ABC-type uncharacterized transport system, periplasmic component [General function prediction only]; Region: COG3683
430066000285	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
430066000286	LysR family transcriptional regulator; Provisional; Region: PRK14997
430066000287	The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422
430066000288	putative effector binding pocket; other site
430066000289	dimerization interface [polypeptide binding]; other site
430066000290	amidase; Provisional; Region: PRK08310
430066000291	indole-3-acetamide amidohydrolase; Region: PLN02722
430066000292	putative cis acting element; BAbS19_IIr0003
430066000293	Diaminopimelate decarboxylase [Amino acid transport and metabolism]; Region: LysA; COG0019
430066000294	Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Ornithine Decarboxylase; Region: PLPDE_III_ODC; cd00622
430066000295	dimer interface [polypeptide binding]; other site
430066000296	active site
430066000297	pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site
430066000298	catalytic residues [active]
430066000299	substrate binding site [chemical binding]; other site
430066000300	Uncharacterized protein involved in exopolysaccharide biosynthesis [Cell envelope biogenesis, outer membrane]; Region: GumC; COG3206
430066000301	Chain length determinant protein; Region: Wzz; pfam02706
430066000302	Teichoic acid biosynthesis proteins [Cell envelope biogenesis, outer membrane]; Region: WecG; COG1922
430066000303	The glycosyltransferase WecG/TagA superfamily contains Escherichia coli WecG, Bacillus subtilis TagA and related proteins. E. coli WecG is believed to be a UDP-N-acetyl-D-mannosaminuronic acid transferase, and is involved in enterobacterial common...; Region: Glyco_transf_WecG_TagA; cd06533
430066000304	Glycosyl transferases group 1; Region: Glyco_trans_1_4; pfam13692
430066000305	Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641
430066000306	Glycosyl transferase family 2; Region: Glycos_transf_2; pfam00535
430066000307	active site
430066000308	Lipid A core - O-antigen ligase and related enzymes [Cell envelope biogenesis, outer membrane]; Region: RfaL; COG3307
430066000309	O-Antigen ligase; Region: Wzy_C; pfam04932
430066000310	Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673
430066000311	Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408
430066000312	Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673
430066000313	Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408
430066000314	Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894
430066000315	6-phosphogluconate dehydrogenase [Carbohydrate transport and metabolism]; Region: Gnd; COG0362
430066000316	6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599
430066000317	6-phosphogluconate dehydrogenase, C-terminal domain; Region: 6PGD; pfam00393
430066000318	ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842
430066000319	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
430066000320	Walker A/P-loop; other site
430066000321	ATP binding site [chemical binding]; other site
430066000322	Q-loop/lid; other site
430066000323	ABC transporter signature motif; other site
430066000324	Walker B; other site
430066000325	D-loop; other site
430066000326	H-loop/switch region; other site
430066000327	TOBE domain; Region: TOBE_2; pfam08402
430066000328	ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177
430066000329	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
430066000330	dimer interface [polypeptide binding]; other site
430066000331	conserved gate region; other site
430066000332	putative PBP binding loops; other site
430066000333	ABC-ATPase subunit interface; other site
430066000334	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
430066000335	dimer interface [polypeptide binding]; other site
430066000336	conserved gate region; other site
430066000337	putative PBP binding loops; other site
430066000338	ABC-ATPase subunit interface; other site
430066000339	Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416
430066000340	ABC-type Fe3+ transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: AfuA; COG1840
430066000341	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
430066000342	Multidrug resistance efflux pump [Defense mechanisms]; Region: EmrA; COG1566
430066000343	HlyD family secretion protein; Region: HlyD_3; pfam13437
430066000344	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
430066000345	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
430066000346	AefR-like transcriptional repressor, C-terminal region; Region: TetR_C_7; pfam14246
430066000347	Autoinducer binding domain; Region: Autoind_bind; pfam03472
430066000348	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
430066000349	DNA binding residues [nucleotide binding]
430066000350	dimerization interface [polypeptide binding]; other site
430066000351	Flagellar biosynthesis pathway, component FlhB [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FlhB; COG1377
430066000352	Uncharacterized homolog of the cytoplasmic domain of flagellar protein FhlB [Function unknown]; Region: COG2257; cl15822
430066000353	Flagellar motor switch protein [Cell motility and secretion]; Region: FliG; COG1536
430066000354	Flagellar motor switch/type III secretory pathway protein [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FliN; COG1886
430066000355	Flagellar motor component [Cell motility and secretion]; Region: MotA; COG1291
430066000356	flagellar motor protein MotA; Validated; Region: PRK09110
430066000357	Protein of unknown function (DUF1217); Region: DUF1217; pfam06748
430066000358	Protein of unknown function (DUF1217); Region: DUF1217; pfam06748
430066000359	flagellar basal body rod protein FlgF; Reviewed; Region: flgF; PRK12642
430066000360	Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460
430066000361	flagellar basal-body rod protein FlgF; Region: flgF; TIGR02490
430066000362	flagellum-specific ATP synthase; Validated; Region: fliI; PRK06002
430066000363	RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233
430066000364	Walker A motif; other site
430066000365	ATP binding site [chemical binding]; other site
430066000366	Walker B motif; other site
430066000367	PAP2_like proteins, Lipid A 1-phosphatase subfamily. Lipid A 1-phosphatase, or LpxE from Francisella novicida selectively dephosphorylates lipid A at the 1-position. Lipid A is the membrane-anchor component of lipopolysaccharides (LPS), the major...; Region: PAP2_lipid_A_1_phosphatase; cd03389
430066000368	active site
430066000369	undecaprenyl phosphate 4-deoxy-4-formamido-L-arabinose transferase; Provisional; Region: PRK10714
430066000370	Bacterial DPM1_like enzymes are related to eukaryotic DPM1; Region: DPM1_like_bac; cd04187
430066000371	Ligand binding site; other site
430066000372	Putative Catalytic site; other site
430066000373	DXD motif; other site
430066000374	Peptidase family M48; Region: Peptidase_M48; cl12018
430066000375	Catalytic domain of glycoside hydrolase (GH) families 38 and 57, lactam utilization protein LamB/YcsF family proteins, YdjC-family proteins, and similar proteins; Region: GH38-57_N_LamB_YdjC_SF; cl17191
430066000376	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family [Cell envelope biogenesis, outer membrane]; Region: ArnT; COG1807
430066000377	Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; cl17364
430066000378	Helix-turn-helix domain; Region: HTH_18; pfam12833
430066000379	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
430066000380	Transposase; Region: HTH_Tnp_1; cl17663
430066000381	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
430066000382	D-galactonate transporter; Region: 2A0114; TIGR00893
430066000383	putative substrate translocation pore; other site
430066000384	putative aldolase; Validated; Region: PRK08130
430066000385	intersubunit interface [polypeptide binding]; other site
430066000386	active site
430066000387	Zn2+ binding site [ion binding]; other site
430066000388	Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451
430066000389	Escherichia coli Gne (a nucleoside-diphosphate-sugar 4-epimerase)-like, extended (e) SDRs; Region: Gne_like_SDR_e; cd05238
430066000390	putative NAD(P) binding site [chemical binding]; other site
430066000391	active site
430066000392	putative substrate binding site [chemical binding]; other site
430066000393	Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349
430066000394	helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420
430066000395	DeoR C terminal sensor domain; Region: DeoRC; pfam00455
430066000396	Hydroxypyruvate isomerase [Carbohydrate transport and metabolism]; Region: Hfi; COG3622
430066000397	AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cl12060
430066000398	Metal-binding active site; metal-binding site
430066000399	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3395
430066000400	flagellar basal body rod protein FlgB; Reviewed; Region: flgB; PRK06003
430066000401	flagellar basal body rod protein FlgC; Reviewed; Region: flgC; PRK12782
430066000402	Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460
430066000403	Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429
430066000404	flagellar hook-basal body protein FliE; Reviewed; Region: fliE; PRK00790
430066000405	flagellar basal body rod protein FlgG; Reviewed; Region: flgG; PRK12691
430066000406	Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429
430066000407	flagellar basal body P-ring biosynthesis protein FlgA; Reviewed; Region: flgA; PRK06005
430066000408	Flagellar basal body P-ring biosynthesis protein [Cell motility and secretion / Posttranslational modification, protein turnover, chaperones]; Region: FlgA; COG1261
430066000409	Uncharacterized conserved protein [Function unknown]; Region: COG3334
430066000410	flagellar basal body L-ring protein; Reviewed; Region: flgH; PRK00249
430066000411	Flagellar basal body L-ring protein [Cell motility and secretion]; Region: FlgH; COG2063
430066000412	Flagellar basal body-associated protein FliL; Region: FliL; pfam03748
430066000413	FliP family; Region: FliP; cl00593
430066000414	Domain of unknown function (DUF4381); Region: DUF4381; pfam14316
430066000415	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4893
430066000416	Transcriptional regulator [Transcription]; Region: LysR; COG0583
430066000417	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
430066000418	The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator, contains the type 2 periplasmic binding fold; Region: PBP2_LTTR_like_1; cd08421
430066000419	putative dimerization interface [polypeptide binding]; other site
430066000420	Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804
430066000421	CoA-transferase family III; Region: CoA_transf_3; pfam02515
430066000422	Uncharacterized conserved protein [Function unknown]; Region: COG3777
430066000423	The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509
430066000424	The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509
430066000425	active site 2 [active]
430066000426	active site 1 [active]
430066000427	Citrate lyase beta subunit [Carbohydrate transport and metabolism]; Region: CitE; COG2301
430066000428	Cytochrome B561 [Energy production and conversion]; Region: CybB; COG3038
430066000429	Autotransporter-associated beta strand repeat; Region: Autotrns_rpt; pfam12951
430066000430	Autotransporter-associated beta strand repeat; Region: Autotrns_rpt; pfam12951
430066000431	Autotransporter-associated beta strand repeat; Region: Autotrns_rpt; pfam12951
430066000432	Autotransporter-associated beta strand repeat; Region: Autotrns_rpt; pfam12951
430066000433	Autotransporter-associated beta strand repeat; Region: Autotrns_rpt; pfam12951
430066000434	Autotransporter-associated beta strand repeat; Region: Autotrns_rpt; pfam12951
430066000435	Autotransporter-associated beta strand repeat; Region: Autotrns_rpt; pfam12951
430066000436	Pertactin-like passenger domains (virulence factors), C-terminal, subgroup 2, of autotransporter proteins of the type V secretion system of Gram-negative bacteria. This subgroup includes the passenger domains of the nonprotease autotransporters, Ag43; Region: PL2_Passenger_AT; cd01344
430066000437	Type V secretory pathway, adhesin AidA [Cell envelope biogenesis, outer membrane / Intracellular trafficking and secretion]; Region: AidA; COG3468
430066000438	Autotransporter beta-domain; Region: Autotransporter; pfam03797
430066000439	Cytochrome c2 [Energy production and conversion]; Region: COG3474
430066000440	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2841
430066000441	transcriptional regulator PdhR; Reviewed; Region: pdhR; PRK09464
430066000442	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
430066000443	DNA-binding site [nucleotide binding]; DNA binding site
430066000444	This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895
430066000445	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
430066000446	transcriptional activator TtdR; Provisional; Region: PRK09801
430066000447	The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422
430066000448	putative effector binding pocket; other site
430066000449	dimerization interface [polypeptide binding]; other site
430066000450	glycolate oxidase subunit GlcD; Provisional; Region: PRK11230
430066000451	FAD binding domain; Region: FAD_binding_4; pfam01565
430066000452	FAD binding domain; Region: FAD_binding_4; pfam01565
430066000453	glycolate oxidase FAD binding subunit; Provisional; Region: glcE; PRK11282
430066000454	glycolate oxidase iron-sulfur subunit; Provisional; Region: glcF; PRK11274
430066000455	The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655
430066000456	Cysteine-rich domain; Region: CCG; pfam02754
430066000457	Cysteine-rich domain; Region: CCG; pfam02754
430066000458	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
430066000459	Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248
430066000460	active site
430066000461	catalytic tetrad [active]
430066000462	Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376
430066000463	Methyladenine glycosylase; Region: Adenine_glyco; pfam03352
430066000464	Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280
430066000465	Histidyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Region: HisS; COG0124
430066000466	Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for...; Region: HisRS-like_core; cd00773
430066000467	dimer interface [polypeptide binding]; other site
430066000468	motif 1; other site
430066000469	motif 2; other site
430066000470	Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA.   PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268
430066000471	active site
430066000472	motif 3; other site
430066000473	HisRS Histidyl-anticodon binding domain. HisRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: HisRS_anticodon; cd00859
430066000474	anticodon binding site; other site
430066000475	ATP phosphoribosyltransferase regulatory subunit; Provisional; Region: hisZ; PRK12295
430066000476	Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA.   PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268
430066000477	motif 1; other site
430066000478	dimer interface [polypeptide binding]; other site
430066000479	active site
430066000480	motif 2; other site
430066000481	Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA.   PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268
430066000482	active site
430066000483	motif 3; other site
430066000484	ATP phosphoribosyltransferase catalytic subunit; Provisional; Region: hisG; PRK13583
430066000485	ATP phosphoribosyltransferase [Amino acid transport and metabolism]; Region: HisG; COG0040
430066000486	Fucose permease [Carbohydrate transport and metabolism]; Region: FucP; COG0738
430066000487	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
430066000488	putative substrate translocation pore; other site
430066000489	Predicted membrane protein [Function unknown]; Region: COG2259
430066000490	fumarate hydratase; Reviewed; Region: fumC; PRK00485
430066000491	Class II fumarases; Region: Fumarase_classII; cd01362
430066000492	active site
430066000493	tetramer interface [polypeptide binding]; other site
430066000494	chaperonin GroEL; Reviewed; Region: groEL; PRK12849
430066000495	GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344
430066000496	ring oligomerisation interface [polypeptide binding]; other site
430066000497	ATP/Mg binding site [chemical binding]; other site
430066000498	stacking interactions; other site
430066000499	hinge regions; other site
430066000500	Chaperonin 10 Kd subunit (cpn10 or GroES); Cpn10 cooperates with chaperonin 60 (cpn60 or GroEL), an ATPase, to assist the folding and assembly of proteins and is found in eubacterial cytosol, as well as in the matrix of mitochondria and chloroplasts. It...; Region: cpn10; cd00320
430066000501	oligomerisation interface [polypeptide binding]; other site
430066000502	mobile loop; other site
430066000503	roof hairpin; other site
430066000504	Predicted sugar phosphatases of the HAD superfamily [Carbohydrate transport and metabolism]; Region: NagD; COG0647
430066000505	Haloacid dehalogenase-like hydrolase; Region: Hydrolase_6; pfam13344
430066000506	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
430066000507	bifunctional riboflavin kinase/FMN adenylyltransferase; Reviewed; Region: PRK05627
430066000508	FAD synthetase, N-terminal domain of the bifunctional enzyme; Region: FAD_synthetase_N; cd02064
430066000509	active site
430066000510	Riboflavin kinase; Region: Flavokinase; smart00904
430066000511	isoleucyl-tRNA synthetase; Provisional; Region: ileS; PRK13804
430066000512	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
430066000513	active site
430066000514	HIGH motif; other site
430066000515	nucleotide binding site [chemical binding]; other site
430066000516	catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818
430066000517	active site
430066000518	KMSKS motif; other site
430066000519	Anticodon-binding domain of bacterial and eukaryotic mitochondrial isoleucyl tRNA synthetases; Region: Anticodon_Ia_Ile_BEm; cd07960
430066000520	tRNA binding surface [nucleotide binding]; other site
430066000521	anticodon binding site; other site
430066000522	Cytochrome B561 [Energy production and conversion]; Region: CybB; COG3038
430066000523	Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285
430066000524	nucleoside/Zn binding site; other site
430066000525	dimer interface [polypeptide binding]; other site
430066000526	catalytic motif [active]
430066000527	16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187
430066000528	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
430066000529	RNA binding surface [nucleotide binding]; other site
430066000530	Pseudouridine synthases catalyze the isomerization of specific uridines in an RNA molecule to pseudouridines (5-ribosyluracil, psi); Region: PseudoU_synth; cl00130
430066000531	active site
430066000532	N6-adenine-specific methylase [DNA replication, recombination, and repair]; Region: COG0742
430066000533	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
430066000534	S-adenosylmethionine binding site [chemical binding]; other site
430066000535	Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612
430066000536	Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675
430066000537	Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193
430066000538	Predicted esterase of the alpha-beta hydrolase superfamily [General function prediction only]; Region: RssA; COG1752
430066000539	Patatins and Phospholipases; Region: Patatin_and_cPLA2; cl11396
430066000540	Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; COG0475
430066000541	Sodium/hydrogen exchanger family; Region: Na_H_Exchanger; pfam00999
430066000542	Kef-type K+ transport systems, predicted NAD-binding component [Inorganic ion transport and metabolism]; Region: Kch; COG1226
430066000543	TrkA-N domain; Region: TrkA_N; pfam02254
430066000544	Predicted Zn-dependent proteases and their inactivated homologs [General function prediction only]; Region: TldD; COG0312
430066000545	Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483
430066000546	CysQ, a 3'-Phosphoadenosine-5'-phosphosulfate (PAPS) 3'-phosphatase, is a bacterial member of the inositol monophosphatase family. It has been proposed that CysQ helps control intracellular levels of PAPS, which is an intermediate in...; Region: CysQ; cd01638
430066000547	active site
430066000548	Domain of unknown function (DUF4170); Region: DUF4170; pfam13773
430066000549	Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: DUF374; Region: LPLAT_DUF374-like; cd07983
430066000550	putative acyl-acceptor binding pocket; other site
430066000551	3-deoxy-D-manno-octulosonic-acid transferase [Cell envelope biogenesis, outer membrane]; Region: KdtA; COG1519
430066000552	3-Deoxy-D-manno-octulosonic-acid transferase (kdotransferase); Region: Glycos_transf_N; pfam04413
430066000553	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013
430066000554	Tetraacyldisaccharide-1-P 4'-kinase [Cell envelope biogenesis, outer membrane]; Region: LpxK; COG1663
430066000555	tetraacyldisaccharide 4'-kinase; Reviewed; Region: lpxK; PRK00652
430066000556	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3908
430066000557	DNA mismatch repair protein; Reviewed; Region: mutL; PRK00095
430066000558	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
430066000559	ATP binding site [chemical binding]; other site
430066000560	Mg2+ binding site [ion binding]; other site
430066000561	G-X-G motif; other site
430066000562	MutL_Trans: transducer domain, having a ribosomal S5 domain 2-like fold, conserved in the C-terminal domain of DNA mismatch repair (MutL/MLH1/PMS2) family. This transducer domain is homologous to the second domain of the DNA gyrase B subunit, which is...; Region: MutL_Trans; cd00782
430066000563	ATP binding site [chemical binding]; other site
430066000564	MutL C terminal dimerisation domain; Region: MutL_C; pfam08676
430066000565	benzoate transport; Region: 2A0115; TIGR00895
430066000566	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
430066000567	putative substrate translocation pore; other site
430066000568	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
430066000569	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
430066000570	active site
430066000571	helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346
430066000572	Transcriptional regulator [Transcription]; Region: IclR; COG1414
430066000573	Bacterial transcriptional regulator; Region: IclR; pfam01614
430066000574	enoyl-CoA hydratase; Provisional; Region: PRK08138
430066000575	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
430066000576	substrate binding site [chemical binding]; other site
430066000577	oxyanion hole (OAH) forming residues; other site
430066000578	trimer interface [polypeptide binding]; other site
430066000579	3-hydroxy-acyl-CoA dehydrogenase; Validated; Region: PRK08268
430066000580	3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737
430066000581	3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725
430066000582	3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725
430066000583	Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804
430066000584	CoA-transferase family III; Region: CoA_transf_3; pfam02515
430066000585	NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902
430066000586	Old yellow enzyme (OYE)-related FMN binding domain, group 2.  Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a reducing agent with oxygens, quinones, and alpha,beta-unsaturated aldehydes and ketones, and can act as...; Region: OYE_like_2_FMN; cd04733
430066000587	putative active site [active]
430066000588	putative FMN binding site [chemical binding]; other site
430066000589	putative substrate binding site [chemical binding]; other site
430066000590	putative catalytic residue [active]
430066000591	Helix-Turn-Helix DNA binding domain of putative transcription regulators from the MerR superfamily; Region: HTH_MerR-like_sg7; cd04786
430066000592	Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789
430066000593	DNA binding residues [nucleotide binding]
430066000594	putative dimer interface [polypeptide binding]; other site
430066000595	sensor protein QseC; Provisional; Region: PRK10337
430066000596	HAMP domain; Region: HAMP; pfam00672
430066000597	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
430066000598	dimer interface [polypeptide binding]; other site
430066000599	phosphorylation site [posttranslational modification]
430066000600	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
430066000601	Mg2+ binding site [ion binding]; other site
430066000602	G-X-G motif; other site
430066000603	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
430066000604	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
430066000605	active site
430066000606	phosphorylation site [posttranslational modification]
430066000607	intermolecular recognition site; other site
430066000608	dimerization interface [polypeptide binding]; other site
430066000609	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
430066000610	DNA binding site [nucleotide binding]
430066000611	Uncharacterized conserved protein [Function unknown]; Region: COG5591
430066000612	Predicted periplasmic protein (DUF2271); Region: DUF2271; pfam10029
430066000613	Membrane-associated lipoprotein involved in thiamine biosynthesis [Coenzyme metabolism]; Region: ApbE; COG1477
430066000614	ApbE family; Region: ApbE; pfam02424
430066000615	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
430066000616	GAF domain; Region: GAF; pfam01590
430066000617	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
430066000618	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
430066000619	metal binding site [ion binding]; metal-binding site
430066000620	active site
430066000621	I-site; other site
430066000622	Protein of unknown function (DUF2778); Region: DUF2778; pfam10908
430066000623	glutathionine S-transferase; Provisional; Region: PRK10542
430066000624	GST_N family, Class Beta subfamily; GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of endogenous and xenobiotic alkylating agents, including carcinogens; Region: GST_N_Beta; cd03057
430066000625	C-terminal domain interface [polypeptide binding]; other site
430066000626	GSH binding site (G-site) [chemical binding]; other site
430066000627	dimer interface [polypeptide binding]; other site
430066000628	C-terminal, alpha helical domain of Class Beta Glutathione S-transferases; Region: GST_C_Beta; cd03188
430066000629	dimer interface [polypeptide binding]; other site
430066000630	N-terminal domain interface [polypeptide binding]; other site
430066000631	substrate binding pocket (H-site) [chemical binding]; other site
430066000632	This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_2; cd07253
430066000633	dimer interface [polypeptide binding]; other site
430066000634	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
430066000635	metal binding site [ion binding]; metal-binding site
430066000636	TonB-dependent copper receptor; Region: TonB-copper; TIGR01778
430066000637	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
430066000638	N-terminal plug; other site
430066000639	ligand-binding site [chemical binding]; other site
430066000640	Transcriptional regulator [Transcription]; Region: IclR; COG1414
430066000641	IclR helix-turn-helix domain; Region: HTH_IclR; cl17605
430066000642	Bacterial transcriptional regulator; Region: IclR; pfam01614
430066000643	ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129
430066000644	First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216
430066000645	Walker A/P-loop; other site
430066000646	ATP binding site [chemical binding]; other site
430066000647	Q-loop/lid; other site
430066000648	ABC transporter signature motif; other site
430066000649	Walker B; other site
430066000650	D-loop; other site
430066000651	H-loop/switch region; other site
430066000652	Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215
430066000653	Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579
430066000654	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
430066000655	TM-ABC transporter signature motif; other site
430066000656	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
430066000657	Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579
430066000658	TM-ABC transporter signature motif; other site
430066000659	This group of proteins belong to a large family of YjgF/YER057c/UK114-like proteins present in bacteria, archaea, and eukaryotes with no definitive function.  The conserved domain is similar in structure to chorismate mutase but there is no sequence...; Region: YjgF_YER057c_UK114_like_2; cd06150
430066000660	homotrimer interaction site [polypeptide binding]; other site
430066000661	putative active site [active]
430066000662	putative sulfite oxidase subunit YedZ; Reviewed; Region: PRK05419
430066000663	TMAO/DMSO reductase; Reviewed; Region: PRK05363
430066000664	YedY_like molybdopterin cofactor (Moco) binding domain, a subgroup of the sulfite oxidase (SO) family of molybdopterin binding domains. Escherichia coli YedY has been propsed to form a heterodimer, consisting of a soluble catalytic subunit termed YedY; Region: YedY_like_Moco; cd02107
430066000665	Moco binding site; other site
430066000666	metal coordination site [ion binding]; other site
430066000667	Predicted esterase [General function prediction only]; Region: COG0400
430066000668	putative hydrolase; Provisional; Region: PRK11460
430066000669	WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cl02567
430066000670	FOG: WD40 repeat [General function prediction only]; Region: COG2319
430066000671	structural tetrad; other site
430066000672	Putative GTPases (G3E family) [General function prediction only]; Region: COG0523
430066000673	The function of this protein family is unkown. The amino acid sequence of YjiA protein in E. coli contains several conserved motifs that characterizes it as a P-loop GTPase. YijA gene is among the genes significantly induced in response to DNA-damage...; Region: CobW_like; cd03112
430066000674	P-loop, Walker A motif; other site
430066000675	Base recognition motif; other site
430066000676	Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; pfam07683
430066000677	Creatinine amidohydrolase; Region: Creatininase; pfam02633
430066000678	MarR family; Region: MarR_2; cl17246
430066000679	transcriptional regulator SlyA; Provisional; Region: PRK03573
430066000680	Transcriptional regulators [Transcription]; Region: PurR; COG1609
430066000681	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
430066000682	DNA binding site [nucleotide binding]
430066000683	domain linker motif; other site
430066000684	Ligand-binding domain of MalI, a transcription regulator of the maltose system of Escherichia coli and its close homologs from other bacteria; Region: PBP1_MalI_like; cd06289
430066000685	putative dimerization interface [polypeptide binding]; other site
430066000686	putative ligand binding site [chemical binding]; other site
430066000687	Hydroxy(phenyl)pyruvate Reductase, D-isomer-specific 2-hydroxyacid-related dehydrogenase; Region: HPPR; cd12156
430066000688	Lactate dehydrogenase and related dehydrogenases [Energy production and conversion / Coenzyme metabolism / General function prediction only]; Region: LdhA; COG1052
430066000689	putative ligand binding site [chemical binding]; other site
430066000690	NAD binding site [chemical binding]; other site
430066000691	catalytic site [active]
430066000692	Predicted glutamine amidotransferases [General function prediction only]; Region: COG2071
430066000693	Subgroup of proteins having the Type 1 glutamine amidotransferase (GATase1) domain; Region: GATase1_2; cd01745
430066000694	catalytic triad [active]
430066000695	gluconate 5-dehydrogenase; Provisional; Region: PRK08213
430066000696	classical (c) SDRs; Region: SDR_c; cd05233
430066000697	NAD(P) binding site [chemical binding]; other site
430066000698	active site
430066000699	Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680
430066000700	Beta-lactamase; Region: Beta-lactamase; pfam00144
430066000701	Acetyltransferase (GNAT) domain; Region: Acetyltransf_5; pfam13444
430066000702	Bacterial aa3 type cytochrome c oxidase subunit IV; Region: COX4_pro_2; pfam07835
430066000703	NAD/NADP transhydrogenase alpha subunit [Energy production and conversion]; Region: PntA; COG3288
430066000704	Rubrum transdehydrogenase NAD-binding and catalytic domains; Region: Rubrum_tdh; cd05304
430066000705	ligand binding site [chemical binding]; other site
430066000706	homodimer interface [polypeptide binding]; other site
430066000707	NAD(P) binding site [chemical binding]; other site
430066000708	trimer interface B [polypeptide binding]; other site
430066000709	trimer interface A [polypeptide binding]; other site
430066000710	Domain of unknown function (DUF3814); Region: DUF3814; pfam12769
430066000711	NAD/NADP transhydrogenase beta subunit [Energy production and conversion]; Region: PntB; COG1282
430066000712	NAD(P) transhydrogenase beta subunit; Region: PNTB; pfam02233
430066000713	Predicted homoserine dehydrogenase [Amino acid transport and metabolism]; Region: COG4091
430066000714	Homoserine dehydrogenase, NAD binding domain; Region: NAD_binding_3; pfam03447
430066000715	SAF domain of putative dehydrogenases or oxidoreductases; Region: SAF_DH_OX_like; cd11616
430066000716	Predicted phosphatase/phosphohexomutase [General function prediction only]; Region: COG0637
430066000717	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
430066000718	motif II; other site
430066000719	NodN (nodulation factor N) contains a single hot dog fold similar to those of the peroxisomal Hydratase-Dehydrogenase-Epimerase (HDE) protein, and the fatty acid synthase beta subunit.  Rhizobium and related species form nodules on the roots of their...; Region: NodN; cd03450
430066000720	putative active site [active]
430066000721	putative catalytic site [active]
430066000722	Alpha/beta hydrolase of unknown function (DUF900); Region: DUF900; pfam05990
430066000723	30S ribosomal protein S21; Reviewed; Region: rpsU; PRK00270
430066000724	type IV pilus biogenesis/stability protein PilW; Region: type_IV_pilW; TIGR02521
430066000725	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
430066000726	TPR motif; other site
430066000727	binding surface
430066000728	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
430066000729	binding surface
430066000730	TPR motif; other site
430066000731	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
430066000732	binding surface
430066000733	TPR motif; other site
430066000734	This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_19; cd07262
430066000735	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
430066000736	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
430066000737	dimer interface [polypeptide binding]; other site
430066000738	conserved gate region; other site
430066000739	ABC-ATPase subunit interface; other site
430066000740	ABC-type metal ion transport system, ATPase component [Inorganic ion transport and metabolism]; Region: AbcC; COG1135
430066000741	ATP-binding cassette domain of methionine transporter; Region: ABC_MetN_methionine_transporter; cd03258
430066000742	Walker A/P-loop; other site
430066000743	ATP binding site [chemical binding]; other site
430066000744	Q-loop/lid; other site
430066000745	ABC transporter signature motif; other site
430066000746	Walker B; other site
430066000747	D-loop; other site
430066000748	H-loop/switch region; other site
430066000749	This domain is found at the C-terminus of ABC transporter proteins involved in D-methionine transport as well as a number of ferredoxin-like proteins; Region: NIL; smart00930
430066000750	ABC-type metal ion transport system, periplasmic component/surface antigen [Inorganic ion transport and metabolism]; Region: NlpA; COG1464
430066000751	NLPA lipoprotein; Region: Lipoprotein_9; pfam03180
430066000752	choline dehydrogenase; Validated; Region: PRK02106
430066000753	GMC oxidoreductase; Region: GMC_oxred_C; pfam05199
430066000754	ABC-type branched-chain amino acid transport system, permease component [Amino acid transport and metabolism]; Region: LivM; COG4177
430066000755	Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581
430066000756	TM-ABC transporter signature motif; other site
430066000757	Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582
430066000758	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
430066000759	TM-ABC transporter signature motif; other site
430066000760	ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410
430066000761	ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224
430066000762	Walker A/P-loop; other site
430066000763	ATP binding site [chemical binding]; other site
430066000764	Q-loop/lid; other site
430066000765	ABC transporter signature motif; other site
430066000766	Walker B; other site
430066000767	D-loop; other site
430066000768	H-loop/switch region; other site
430066000769	ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411
430066000770	ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219
430066000771	Walker A/P-loop; other site
430066000772	ATP binding site [chemical binding]; other site
430066000773	Q-loop/lid; other site
430066000774	ABC transporter signature motif; other site
430066000775	Walker B; other site
430066000776	D-loop; other site
430066000777	H-loop/switch region; other site
430066000778	Periplasmic binding protein; Region: Peripla_BP_6; pfam13458
430066000779	Periplasmic solute-binding domain of active transport proteins that belong to the type I periplasmic binding fold protein family; Region: PBP1_SBP_like_1; cd06327
430066000780	putative ligand binding site [chemical binding]; other site
430066000781	Transcriptional regulator [Transcription]; Region: LysR; COG0583
430066000782	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
430066000783	LysR substrate binding domain; Region: LysR_substrate; pfam03466
430066000784	dimerization interface [polypeptide binding]; other site
430066000785	Transcriptional regulators [Transcription]; Region: Lrp; COG1522
430066000786	Winged helix-turn-helix DNA-binding; Region: HTH_24; pfam13412
430066000787	AsnC family; Region: AsnC_trans_reg; pfam01037
430066000788	hypothetical protein; Provisional; Region: PRK06148
430066000789	Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270
430066000790	active site
430066000791	substrate binding site [chemical binding]; other site
430066000792	ATP binding site [chemical binding]; other site
430066000793	Peptidase family M23; Region: Peptidase_M23; pfam01551
430066000794	Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610
430066000795	inhibitor-cofactor binding pocket; inhibition site
430066000796	pyridoxal 5'-phosphate binding site [chemical binding]; other site
430066000797	catalytic residue [active]
430066000798	lysine-arginine-ornithine-binding periplasmic protein; Region: 3A0103s03R; TIGR01096
430066000799	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
430066000800	substrate binding pocket [chemical binding]; other site
430066000801	membrane-bound complex binding site; other site
430066000802	hinge residues; other site
430066000803	D-aminopeptidase; Reviewed; Region: PRK13128
430066000804	Beta-lactamase; Region: Beta-lactamase; pfam00144
430066000805	D-aminopeptidase, domain B; Region: DAP_B; pfam07930
430066000806	D-aminopeptidase, domain C; Region: DAP_C; pfam07932
430066000807	thiamine pyrophosphate protein; Validated; Region: PRK08199
430066000808	Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035
430066000809	PYR/PP interface [polypeptide binding]; other site
430066000810	dimer interface [polypeptide binding]; other site
430066000811	TPP binding site [chemical binding]; other site
430066000812	Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205
430066000813	Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cd00568
430066000814	TPP-binding site [chemical binding]; other site
430066000815	Transcriptional regulators [Transcription]; Region: FadR; COG2186
430066000816	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
430066000817	DNA-binding site [nucleotide binding]; DNA binding site
430066000818	FCD domain; Region: FCD; pfam07729
430066000819	Uncharacterized protein conserved in bacteria [Function unknown]; Region: GguC; COG3802
430066000820	Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557
430066000821	Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673
430066000822	Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408
430066000823	dihydroxy-acid dehydratase; Provisional; Region: PRK13017
430066000824	2-keto-3-deoxy-galactonokinase [Carbohydrate transport and metabolism]; Region: DgoK; COG3734
430066000825	2-keto-3-deoxy-galactonokinase; Region: DGOK; pfam05035
430066000826	2-dehydro-3-deoxy-6-phosphogalactonate aldolase; Reviewed; Region: PRK09140
430066000827	KDPG and KHG aldolase; Region: KDPG_aldolase; cd00452
430066000828	active site
430066000829	intersubunit interface [polypeptide binding]; other site
430066000830	catalytic residue [active]
430066000831	ABC-type xylose transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: XylF; COG4213
430066000832	Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011
430066000833	ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129
430066000834	First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216
430066000835	Walker A/P-loop; other site
430066000836	ATP binding site [chemical binding]; other site
430066000837	Q-loop/lid; other site
430066000838	ABC transporter signature motif; other site
430066000839	Walker B; other site
430066000840	D-loop; other site
430066000841	H-loop/switch region; other site
430066000842	Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215
430066000843	Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579
430066000844	Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579
430066000845	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
430066000846	TM-ABC transporter signature motif; other site
430066000847	Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115
430066000848	D-Alanine aminotransferase (D-AAT_like): D-amino acid aminotransferase catalyzes transamination between D-amino acids and their respective alpha-keto acids. It plays a major role in the synthesis of bacterial cell wall components like D-alanine and...; Region: D-AAT_like; cd01558
430066000849	homodimer interface [polypeptide binding]; other site
430066000850	substrate-cofactor binding pocket; other site
430066000851	pyridoxal 5'-phosphate binding site [chemical binding]; other site
430066000852	catalytic residue [active]
430066000853	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3758
430066000854	urocanate hydratase; Provisional; Region: PRK05414
430066000855	N-formylglutamate amidohydrolase; Region: hutG_amidohyd; TIGR02017
430066000856	Phenylalanine ammonia-lyase (PAL) and histidine ammonia-lyase (HAL); Region: PAL-HAL; cd00332
430066000857	active sites [active]
430066000858	tetramer interface [polypeptide binding]; other site
430066000859	imidazolonepropionase; Validated; Region: PRK09356
430066000860	Imidazolonepropionase/imidazolone-5-propionate hydrolase (Imidazolone-5PH) catalyzes the third step in the histidine degradation pathway, the hydrolysis of (S)-3-(5-oxo-4,5-dihydro-3H-imidazol-4-yl)propanoate to N-formimidoyl-L-glutamate. In bacteria; Region: Imidazolone-5PH; cd01296
430066000861	active site
430066000862	N-formimino-L-glutamate deiminase; Validated; Region: PRK09229
430066000863	Metallo-dependent hydrolases, subgroup D is part of the superfamily of metallo-dependent hydrolases, a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the...; Region: Met_dep_hydrolase_E; cd01313
430066000864	active site
430066000865	histidine utilization repressor, proteobacterial; Region: his_ut_repres; TIGR02018
430066000866	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
430066000867	DNA-binding site [nucleotide binding]; DNA binding site
430066000868	UTRA domain; Region: UTRA; pfam07702
430066000869	beta alanine--pyruvate transaminase; Provisional; Region: PRK09221
430066000870	Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610
430066000871	inhibitor-cofactor binding pocket; inhibition site
430066000872	pyridoxal 5'-phosphate binding site [chemical binding]; other site
430066000873	catalytic residue [active]
430066000874	DNA-binding transcriptional repressor PuuR; Provisional; Region: PRK09943
430066000875	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
430066000876	non-specific DNA binding site [nucleotide binding]; other site
430066000877	salt bridge; other site
430066000878	sequence-specific DNA binding site [nucleotide binding]; other site
430066000879	Cupin domain; Region: Cupin_2; pfam07883
430066000880	D-amino acid dehydrogenase small subunit; Validated; Region: PRK00711
430066000881	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
430066000882	hydroxyglutarate oxidase; Provisional; Region: PRK11728
430066000883	Alanine racemase [Cell envelope biogenesis, outer membrane]; Region: Alr; COG0787
430066000884	Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Alanine Racemase; Region: PLPDE_III_AR; cd00430
430066000885	active site
430066000886	pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site
430066000887	dimer interface [polypeptide binding]; other site
430066000888	substrate binding site [chemical binding]; other site
430066000889	catalytic residues [active]
430066000890	Transcriptional regulators [Transcription]; Region: Lrp; COG1522
430066000891	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
430066000892	putative DNA binding site [nucleotide binding]; other site
430066000893	putative Zn2+ binding site [ion binding]; other site
430066000894	AsnC family; Region: AsnC_trans_reg; pfam01037
430066000895	Opacity protein and related surface antigens [Cell envelope biogenesis, outer membrane]; Region: COG3637
430066000896	Isopentenyl diphosphate isomerase (BS_ypgA, MTH48 and related proteins) [Coenzyme transport and metabolism]; Region: idi; COG1304
430066000897	TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186
430066000898	phosphate binding site [ion binding]; other site
430066000899	oxidoreductase alpha (molybdopterin) subunit; Region: Fdhalpha-like; TIGR01701
430066000900	The MopB_ydeP CD includes a group of related uncharacterized bacterial molybdopterin-binding oxidoreductase-like domains with a putative molybdopterin cofactor binding site. These members belong to the molybdopterin_binding (MopB) superfamily of proteins; Region: MopB_ydeP; cd02767
430066000901	putative molybdopterin cofactor binding site [chemical binding]; other site
430066000902	The MopB_CT_ydeP CD includes a group of related uncharacterized bacterial molybdopterin-binding oxidoreductase-like domains with a putative molybdopterin cofactor binding site. This CD is of the conserved molybdopterin_binding C-terminal (MopB_CT) region...; Region: MopB_CT_ydeP; cd02787
430066000903	putative molybdopterin cofactor binding site; other site
430066000904	RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730
430066000905	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
430066000906	HlyD family secretion protein; Region: HlyD_3; pfam13437
430066000907	putative membrane fusion protein; Region: TIGR02828
430066000908	RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730
430066000909	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
430066000910	HlyD family secretion protein; Region: HlyD_3; pfam13437
430066000911	Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841
430066000912	Transcriptional regulators [Transcription]; Region: PhnF; COG2188
430066000913	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
430066000914	DNA-binding site [nucleotide binding]; DNA binding site
430066000915	UTRA domain; Region: UTRA; pfam07702
430066000916	Predicted phosphosugar isomerases [Cell envelope biogenesis, outer membrane]; Region: AgaS; COG2222
430066000917	SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008
430066000918	dimer interface [polypeptide binding]; other site
430066000919	active site
430066000920	SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009
430066000921	dimer interface [polypeptide binding]; other site
430066000922	active site
430066000923	N-acetylglucosamine-6-phosphate deacetylase [Carbohydrate transport and metabolism]; Region: NagA; COG1820
430066000924	N-acetylglucosamine-6-phosphate deacetylase, NagA, catalyzes the hydrolysis of the N-acetyl group of N-acetyl-glucosamine-6-phosphate (GlcNAc-6-P) to glucosamine 6-phosphate and acetate. This is the first committed step in the biosynthetic pathway to...; Region: NagA; cd00854
430066000925	active site
430066000926	dimer interface [polypeptide binding]; other site
430066000927	hypothetical protein; Provisional; Region: PRK02947
430066000928	RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013
430066000929	putative active site [active]
430066000930	formyltetrahydrofolate deformylase; Reviewed; Region: PRK13011
430066000931	N-terminal ACT domain of formyltetrahydrofolate deformylase (F4HF-DF; formyltetrahydrofolate hydrolase); Region: ACT_F4HF-DF; cd04875
430066000932	Formyltetrahydrofolate deformylase (Formyl-FH4 hydrolase), C-terminal hydrolase domain; Region: FMT_core_Formyl-FH4-Hydrolase_C; cd08648
430066000933	putative active site [active]
430066000934	putative substrate binding site [chemical binding]; other site
430066000935	putative cosubstrate binding site; other site
430066000936	catalytic site [active]
430066000937	aldehyde dehydrogenase family 7 member; Region: PLN02315
430066000938	NAD+-dependent alpha-aminoadipic semialdehyde dehydrogenase, ALDH family members 7A1 and 7B; Region: ALDH_F7_AASADH; cd07130
430066000939	tetrameric interface [polypeptide binding]; other site
430066000940	NAD binding site [chemical binding]; other site
430066000941	catalytic residues [active]
430066000942	Domain of unknown function (DUF1338); Region: DUF1338; pfam07063
430066000943	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5383
430066000944	DNA-binding transcriptional activator GcvA; Provisional; Region: PRK11139
430066000945	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
430066000946	putative Zn2+ binding site [ion binding]; other site
430066000947	putative DNA binding site [nucleotide binding]; other site
430066000948	dimerization interface [polypeptide binding]; other site
430066000949	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
430066000950	dimerization interface [polypeptide binding]; other site
430066000951	putative aminophosphonate oxidoreductase; Region: Phn_aa_oxid; TIGR03329
430066000952	Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665
430066000953	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
430066000954	dimerization interface [polypeptide binding]; other site
430066000955	putative DNA binding site [nucleotide binding]; other site
430066000956	putative Zn2+ binding site [ion binding]; other site
430066000957	NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902
430066000958	Old yellow enzyme (OYE)-like FMN binding domain. OYE was the first flavin-dependent enzyme identified, however its true physiological role remains elusive to this day. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a...; Region: OYE_like_FMN; cd02933
430066000959	FMN binding site [chemical binding]; other site
430066000960	active site
430066000961	substrate binding site [chemical binding]; other site
430066000962	catalytic residue [active]
430066000963	Transcriptional regulators [Transcription]; Region: Lrp; COG1522
430066000964	AsnC-type helix-turn-helix domain; Region: HTH_AsnC-type; pfam13404
430066000965	AsnC family; Region: AsnC_trans_reg; pfam01037
430066000966	Arginase family; Region: Arginase; cd09989
430066000967	agmatinase; Region: agmatinase; TIGR01230
430066000968	active site
430066000969	Mn binding site [ion binding]; other site
430066000970	oligomer interface [polypeptide binding]; other site
430066000971	ornithine cyclodeaminase; Validated; Region: PRK07589
430066000972	ornithine cyclodeaminase; Validated; Region: PRK06823; cl17400
430066000973	Truncated hemoglobins (trHbs) are a family of oxygen-binding heme proteins found in cyanobacteria, eubacteria, unicellular eukaryotes, and plants. The truncated hemoglobins have a characteristic two-over-two alpha helical folding pattern that is distinct...; Region: Trunc_globin; cd00454
430066000974	apolar tunnel; other site
430066000975	heme binding site [chemical binding]; other site
430066000976	dimerization interface [polypeptide binding]; other site
430066000977	This CD includes bacterial (Agrobacterium tumefaciens and Caulobacter crescentus ProX, and Clostridium sticklandii PrdX) and eukaryotic (Plasmodium falciparum N-terminal ProRS editing domain) sequences. The C. sticklandii PrdX protein, a homolog of the...; Region: PrdX_deacylase; cd04335
430066000978	putative deacylase active site [active]
430066000979	Thioredoxin domain-containing protein [Posttranslational modification, protein turnover, chaperones]; Region: COG3118
430066000980	TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947
430066000981	catalytic residues [active]
430066000982	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429
430066000983	binding surface
430066000984	TPR motif; other site
430066000985	Uncharacterized protein, similar to the N-terminal domain of Lon protease [General function prediction only]; Region: COG2802
430066000986	Uncharacterized conserved protein [Function unknown]; Region: COG2835
430066000987	tartrate dehydrogenase; Region: TTC; TIGR02089
430066000988	3-isopropylmalate dehydrogenase; Provisional; Region: PRK00772
430066000989	Adenosine deaminase [Nucleotide transport and metabolism]; Region: Ada; COG2169
430066000990	Metal binding domain of Ada; Region: Ada_Zn_binding; pfam02805
430066000991	Methylated DNA-protein cysteine methyltransferase [DNA replication, recombination, and repair]; Region: Ada; COG0350
430066000992	The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445
430066000993	DNA binding site [nucleotide binding]
430066000994	active site
430066000995	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
430066000996	putative substrate translocation pore; other site
430066000997	aspartate-semialdehyde dehydrogenase; Provisional; Region: PRK14874
430066000998	Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859
430066000999	Transcriptional regulators [Transcription]; Region: MarR; COG1846
430066001000	MarR family; Region: MarR; pfam01047
430066001001	peroxiredoxin, Ohr subfamily; Region: organ_hyd_perox; TIGR03561
430066001002	Minimal MMP-like domain found in Acidothermus cellulolyticus hypothetical protein ACEL2062 and similar protein; Region: MMP_ACEL2062; cd12952
430066001003	isopropylmalate isomerase small subunit; Provisional; Region: leuD; PRK01641
430066001004	Aconatase-like swivel domain of 3-isopropylmalate dehydratase and related uncharacterized proteins. 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate...; Region: IPMI_Swivel; cd01577
430066001005	substrate binding site [chemical binding]; other site
430066001006	Citrate lyase beta subunit [Carbohydrate transport and metabolism]; Region: CitE; COG2301
430066001007	Uncharacterized conserved small protein [Function unknown]; Region: COG5515
430066001008	This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_5; cd07238
430066001009	dimer interface [polypeptide binding]; other site
430066001010	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
430066001011	Zn-dependent oligopeptidases [Amino acid transport and metabolism]; Region: Dcp; COG0339
430066001012	Peptidase family M3 dipeptidyl carboxypeptidase (DCP); Region: M3A_DCP; cd06456
430066001013	active site
430066001014	Zn binding site [ion binding]; other site
430066001015	Mg/Co/Ni transporter MgtE (contains CBS domain) [Inorganic ion transport and metabolism]; Region: MgtE; COG2239
430066001016	MgtE intracellular N domain; Region: MgtE_N; pfam03448
430066001017	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domain in the magnesium transporter, MgtE.  MgtE and its homologs are found in eubacteria, archaebacteria, and eukaryota. Members of this family transport Mg2+ or other...; Region: CBS_pair_Mg_transporter; cd04606
430066001018	Divalent cation transporter; Region: MgtE; pfam01769
430066001019	Predicted membrane GTPase involved in stress response [Signal transduction mechanisms]; Region: TypA; COG1217
430066001020	Tyrosine phosphorylated protein A (TypA)/BipA family belongs to ribosome-binding GTPases; Region: TypA_BipA; cd01891
430066001021	G1 box; other site
430066001022	putative GEF interaction site [polypeptide binding]; other site
430066001023	GTP/Mg2+ binding site [chemical binding]; other site
430066001024	Switch I region; other site
430066001025	G2 box; other site
430066001026	G3 box; other site
430066001027	Switch II region; other site
430066001028	G4 box; other site
430066001029	G5 box; other site
430066001030	BipA_TypA_II: domain II of BipA (also called TypA) having homology to domain II of the elongation factors (EFs) EF-G and EF-Tu.  BipA is a highly conserved protein with global regulatory properties in Escherichia coli. BipA is phosphorylated on a...; Region: BipA_TypA_II; cd03691
430066001031	BipA_TypA_C: a C-terminal portion of BipA or TypA having homology to the C terminal domains of the elongation factors EF-G and EF-2. A member of the ribosome binding GTPase superfamily, BipA is widely distributed in bacteria and plants.  BipA is a highly...; Region: BipA_TypA_C; cd03710
430066001032	Uncharacterized conserved protein [Function unknown]; Region: COG1739
430066001033	Uncharacterized protein family UPF0029; Region: UPF0029; pfam01205
430066001034	Domain of unknown function (DUF1949); Region: DUF1949; pfam09186
430066001035	Fructose-1,6-bisphosphatase, an enzyme that catalyzes the hydrolysis of fructose-1,6-biphosphate  into fructose-6-phosphate and is critical in gluconeogenesis pathway. The alignment model also includes chloroplastic FBPases and sedoheptulose-1; Region: FBPase; cd00354
430066001036	AMP binding site [chemical binding]; other site
430066001037	metal binding site [ion binding]; metal-binding site
430066001038	active site
430066001039	fructose-bisphosphate aldolase; Provisional; Region: PRK09197
430066001040	Tagatose-1,6-bisphosphate (TBP) aldolase and related Type B Class II aldolases. TBP aldolase is a tetrameric class II aldolase that catalyzes the reversible condensation of dihydroxyacetone phosphate with glyceraldehyde 3-phsophate to produce tagatose 1; Region: TBP_aldolase_IIB; cd00947
430066001041	intersubunit interface [polypeptide binding]; other site
430066001042	active site
430066001043	zinc binding site [ion binding]; other site
430066001044	Na+ binding site [ion binding]; other site
430066001045	ribose-5-phosphate isomerase B; Provisional; Region: PRK05571
430066001046	triosephosphate isomerase; Provisional; Region: PRK14565
430066001047	Triosephosphate isomerase (TIM) is a glycolytic enzyme that catalyzes the interconversion of dihydroxyacetone phosphate and D-glyceraldehyde-3-phosphate. The reaction is very efficient and requires neither cofactors nor metal ions. TIM, usually...; Region: TIM; cd00311
430066001048	substrate binding site [chemical binding]; other site
430066001049	dimer interface [polypeptide binding]; other site
430066001050	catalytic triad [active]
430066001051	Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349
430066001052	helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420
430066001053	DeoR C terminal sensor domain; Region: DeoRC; pfam00455
430066001054	Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261
430066001055	Putative sugar-binding domain; Region: Sugar-bind; pfam04198
430066001056	glycerol-3-phosphate dehydrogenase; Provisional; Region: PRK13369
430066001057	hydroxyglutarate oxidase; Provisional; Region: PRK11728
430066001058	Sugar (pentulose and hexulose) kinases [Carbohydrate transport and metabolism]; Region: XylB; COG1070
430066001059	L-xylulose kinases; a subfamily of the FGGY family of carbohydrate kinases; Region: FGGY_L-XK; cd07802
430066001060	putative N- and C-terminal domain interface [polypeptide binding]; other site
430066001061	putative active site [active]
430066001062	MgATP binding site [chemical binding]; other site
430066001063	catalytic site [active]
430066001064	metal binding site [ion binding]; metal-binding site
430066001065	putative xylulose binding site [chemical binding]; other site
430066001066	Predicted periplasmic lipoprotein (DUF2291); Region: DUF2291; pfam10054
430066001067	ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129
430066001068	First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216
430066001069	Walker A/P-loop; other site
430066001070	ATP binding site [chemical binding]; other site
430066001071	Q-loop/lid; other site
430066001072	ABC transporter signature motif; other site
430066001073	Walker B; other site
430066001074	D-loop; other site
430066001075	H-loop/switch region; other site
430066001076	Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215
430066001077	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
430066001078	Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579
430066001079	TM-ABC transporter signature motif; other site
430066001080	Periplasmic sugar-binding domain of the thermophilic Thermoanaerobacter tengcongensis ribose binding protein (ttRBP) and its mesophilic homologs; Region: PBP1_ribose_binding; cd06323
430066001081	Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407
430066001082	ligand binding site [chemical binding]; other site
430066001083	dimerization interface [polypeptide binding]; other site
430066001084	Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349
430066001085	DeoR-like helix-turn-helix domain; Region: HTH_DeoR; cl17531
430066001086	DeoR C terminal sensor domain; Region: DeoRC; pfam00455
430066001087	FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277
430066001088	FAD binding domain; Region: FAD_binding_4; pfam01565
430066001089	4-amino-4-deoxy-L-arabinose-phosphoundecaprenol flippase subunit ArnF; Provisional; Region: PRK02971
430066001090	Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451
430066001091	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
430066001092	active site
430066001093	Ornithine/acetylornithine aminotransferase [Amino acid transport and metabolism]; Region: ArgD; COG4992
430066001094	Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610
430066001095	inhibitor-cofactor binding pocket; inhibition site
430066001096	pyridoxal 5'-phosphate binding site [chemical binding]; other site
430066001097	catalytic residue [active]
430066001098	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3293
430066001099	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
430066001100	Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340
430066001101	Protein of unknown function DUF91; Region: DUF91; cl00709
430066001102	Uncharacterized conserved protein [Function unknown]; Region: COG3586
430066001103	Protein of unknown function DUF45; Region: DUF45; pfam01863
430066001104	Type I site-specific restriction-modification system, R (restriction) subunit and related helicases [Defense mechanisms]; Region: COG0610
430066001105	Type I restriction enzyme R protein N terminus (HSDR_N); Region: HSDR_N; pfam04313
430066001106	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
430066001107	ATP binding site [chemical binding]; other site
430066001108	putative Mg++ binding site [ion binding]; other site
430066001109	helicase superfamily c-terminal domain; Region: HELICc; smart00490
430066001110	Domain of unknown function (DUF3387); Region: DUF3387; pfam11867
430066001111	Restriction endonuclease S subunits [Defense mechanisms]; Region: HsdS; COG0732
430066001112	Type I restriction-modification system methyltransferase subunit [Defense mechanisms]; Region: HsdM; COG0286
430066001113	HsdM N-terminal domain; Region: HsdM_N; pfam12161
430066001114	Methyltransferase domain; Region: Methyltransf_26; pfam13659
430066001115	Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420
430066001116	Restriction endonuclease S subunits [Defense mechanisms]; Region: HsdS; COG0732
430066001117	Dioxygenases related to 2-nitropropane dioxygenase [General function prediction only]; Region: COG2070
430066001118	2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730
430066001119	FMN binding site [chemical binding]; other site
430066001120	substrate binding site [chemical binding]; other site
430066001121	putative catalytic residue [active]
430066001122	DEXH box helicase, DNA ligase-associated; Region: DEXH_lig_assoc; TIGR04121
430066001123	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
430066001124	ATP binding site [chemical binding]; other site
430066001125	putative Mg++ binding site [ion binding]; other site
430066001126	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
430066001127	nucleotide binding region [chemical binding]; other site
430066001128	ATP-binding site [chemical binding]; other site
430066001129	DEAD/H associated; Region: DEAD_assoc; pfam08494
430066001130	Pyrococcus furiosus PF1019 and related proteins, metallophosphatase domain; Region: MPP_PF1019; cd07391
430066001131	putative active site [active]
430066001132	putative metal binding site [ion binding]; other site
430066001133	conserved hypothetical protein; Region: alph_Pro_TM; TIGR02186
430066001134	Sulfite exporter TauE/SafE; Region: TauE; pfam01925
430066001135	FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790
430066001136	Sel1-like repeats; Region: SEL1; smart00671
430066001137	Sel1-like repeats; Region: SEL1; smart00671
430066001138	Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471
430066001139	Helix-Turn-Helix DNA binding domain of the regulatory protein GnyR; Region: HTH_GnyR; cd04776
430066001140	Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789
430066001141	DNA binding residues [nucleotide binding]
430066001142	putative dimer interface [polypeptide binding]; other site
430066001143	PII-like signaling protein [Signal transduction mechanisms]; Region: COG1993
430066001144	camphor resistance protein CrcB; Provisional; Region: PRK14225
430066001145	camphor resistance protein CrcB; Provisional; Region: PRK14233
430066001146	mannonate dehydratase; Region: uxuA; TIGR00695
430066001147	mannonate dehydratase; Provisional; Region: PRK03906
430066001148	Transcriptional regulators [Transcription]; Region: GntR; COG1802
430066001149	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
430066001150	DNA-binding site [nucleotide binding]; DNA binding site
430066001151	FCD domain; Region: FCD; pfam07729
430066001152	Glucuronate isomerase [Carbohydrate transport and metabolism]; Region: UxaC; COG1904
430066001153	glucuronate isomerase; Reviewed; Region: PRK02925
430066001154	Glucuronate isomerase; Region: UxaC; cl00829
430066001155	Glucuronate isomerase [Carbohydrate transport and metabolism]; Region: UxaC; COG1904
430066001156	Mannitol-1-phosphate/altronate dehydrogenases [Carbohydrate transport and metabolism]; Region: MtlD; COG0246
430066001157	Mannitol dehydrogenase Rossmann domain; Region: Mannitol_dh; pfam01232
430066001158	Mannitol dehydrogenase C-terminal domain; Region: Mannitol_dh_C; pfam08125
430066001159	ABC-type uncharacterized transport system, periplasmic component [General function prediction only]; Region: COG4134
430066001160	hypothetical protein; Provisional; Region: PRK11622
430066001161	ABC-type sugar transport systems, ATPase components [Carbohydrate transport and metabolism]; Region: MalK; COG3839
430066001162	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
430066001163	Walker A/P-loop; other site
430066001164	ATP binding site [chemical binding]; other site
430066001165	Q-loop/lid; other site
430066001166	ABC transporter signature motif; other site
430066001167	Walker B; other site
430066001168	D-loop; other site
430066001169	H-loop/switch region; other site
430066001170	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427
430066001171	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
430066001172	putative PBP binding loops; other site
430066001173	ABC-ATPase subunit interface; other site
430066001174	ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177
430066001175	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
430066001176	dimer interface [polypeptide binding]; other site
430066001177	conserved gate region; other site
430066001178	putative PBP binding loops; other site
430066001179	ABC-ATPase subunit interface; other site
430066001180	Domains similar to fish antifreeze type III protein; Region: SAF_AH_GD; cd11613
430066001181	galactarate dehydratase; Region: galactar-dH20; TIGR03248
430066001182	D-galactarate dehydratase / Altronate hydrolase, C terminus; Region: GD_AH_C; pfam04295
430066001183	nickel responsive regulator; Provisional; Region: PRK02967
430066001184	Ribbon-helix-helix protein, copG family; Region: RHH_1; pfam01402
430066001185	NikR C terminal nickel binding domain; Region: NikR_C; pfam08753
430066001186	nickel transporter permease NikB; Provisional; Region: PRK10352
430066001187	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
430066001188	dimer interface [polypeptide binding]; other site
430066001189	conserved gate region; other site
430066001190	putative PBP binding loops; other site
430066001191	ABC-ATPase subunit interface; other site
430066001192	nickel transporter permease NikC; Provisional; Region: nikC; PRK10417
430066001193	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
430066001194	dimer interface [polypeptide binding]; other site
430066001195	conserved gate region; other site
430066001196	putative PBP binding loops; other site
430066001197	ABC-ATPase subunit interface; other site
430066001198	nickel transporter ATP-binding protein NikD; Provisional; Region: nikD; PRK10418
430066001199	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
430066001200	Walker A/P-loop; other site
430066001201	ATP binding site [chemical binding]; other site
430066001202	Q-loop/lid; other site
430066001203	ABC transporter signature motif; other site
430066001204	Walker B; other site
430066001205	D-loop; other site
430066001206	H-loop/switch region; other site
430066001207	nickel transporter ATP-binding protein NikE; Provisional; Region: nikE; PRK10419
430066001208	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
430066001209	Walker A/P-loop; other site
430066001210	ATP binding site [chemical binding]; other site
430066001211	Q-loop/lid; other site
430066001212	ABC transporter signature motif; other site
430066001213	Walker B; other site
430066001214	D-loop; other site
430066001215	H-loop/switch region; other site
430066001216	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
430066001217	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
430066001218	active site
430066001219	Transcriptional regulator [Transcription]; Region: LysR; COG0583
430066001220	The C-teminal substrate binding domain of LysR-like nitrogen assimilation control (NAC) protein, contains the type 2 periplasmic binding fold; Region: PBP2_Nac; cd08433
430066001221	putative dimerization interface [polypeptide binding]; other site
430066001222	Acyl-CoA dehydrogenase N terminal; Region: AcylCoA_DH_N; pfam12418
430066001223	acyl-CoA dehydrogenase; Provisional; Region: PTZ00456
430066001224	Putative acyl-CoA dehydrogenases similar to fadE5; Region: ACAD_fadE5; cd01153
430066001225	FAD binding site [chemical binding]; other site
430066001226	substrate binding site [chemical binding]; other site
430066001227	catalytic residues [active]
430066001228	Acetyl-CoA dehydrogenase C-terminal like; Region: Acyl-CoA_dh_C; pfam12806
430066001229	acetyl-CoA acetyltransferase; Validated; Region: PRK08242
430066001230	Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751
430066001231	dimer interface [polypeptide binding]; other site
430066001232	active site
430066001233	multifunctional fatty acid oxidation complex subunit alpha; Reviewed; Region: fadJ; PRK11154
430066001234	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
430066001235	substrate binding site [chemical binding]; other site
430066001236	oxyanion hole (OAH) forming residues; other site
430066001237	trimer interface [polypeptide binding]; other site
430066001238	3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737
430066001239	3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725
430066001240	Predicted transcriptional regulator [Transcription]; Region: COG2932
430066001241	Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529
430066001242	Catalytic site [active]
430066001243	Micrococcal nuclease (thermonuclease) homologs [DNA replication, recombination, and repair]; Region: COG1525
430066001244	lysyl-tRNA synthetase; Reviewed; Region: lysK; PRK00750
430066001245	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
430066001246	active site
430066001247	nucleotide binding site [chemical binding]; other site
430066001248	HIGH motif; other site
430066001249	KMSKS motif; other site
430066001250	tellurite resistance protein terB; Region: terB; cd07176
430066001251	putative metal binding site [ion binding]; other site
430066001252	Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA_cladeA; cd00883
430066001253	active site clefts [active]
430066001254	zinc binding site [ion binding]; other site
430066001255	dimer interface [polypeptide binding]; other site
430066001256	Eukaryotic translation initiation factor 3 subunit 8 N-terminus; Region: eIF-3c_N; pfam05470
430066001257	ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747
430066001258	The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_13; cd08517
430066001259	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601
430066001260	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
430066001261	dimer interface [polypeptide binding]; other site
430066001262	conserved gate region; other site
430066001263	putative PBP binding loops; other site
430066001264	ABC-ATPase subunit interface; other site
430066001265	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173
430066001266	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
430066001267	dimer interface [polypeptide binding]; other site
430066001268	conserved gate region; other site
430066001269	putative PBP binding loops; other site
430066001270	ABC-ATPase subunit interface; other site
430066001271	ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124
430066001272	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
430066001273	Walker A/P-loop; other site
430066001274	ATP binding site [chemical binding]; other site
430066001275	Q-loop/lid; other site
430066001276	ABC transporter signature motif; other site
430066001277	Walker B; other site
430066001278	D-loop; other site
430066001279	H-loop/switch region; other site
430066001280	ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124
430066001281	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
430066001282	Walker A/P-loop; other site
430066001283	ATP binding site [chemical binding]; other site
430066001284	Q-loop/lid; other site
430066001285	ABC transporter signature motif; other site
430066001286	Walker B; other site
430066001287	D-loop; other site
430066001288	H-loop/switch region; other site
430066001289	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097
430066001290	pyrroline-5-carboxylate reductase; Reviewed; Region: PRK11880
430066001291	NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; cl17232
430066001292	bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate cyclohydrolase; Provisional; Region: PRK14188
430066001293	Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain; Region: THF_DHG_CYH; pfam00763
430066001294	NADP binding domain of methylene-tetrahydrofolate dehydrogenase/cyclohydrolase; Region: NAD_bind_m-THF_DH_Cyclohyd; cd01080
430066001295	homodimer interface [polypeptide binding]; other site
430066001296	NADP binding site [chemical binding]; other site
430066001297	substrate binding site [chemical binding]; other site
430066001298	phosphogluconate dehydratase; Validated; Region: PRK09054
430066001299	6-phosphogluconate dehydratase; Region: edd; TIGR01196
430066001300	6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase [Carbohydrate transport and metabolism]; Region: NagB; COG0363
430066001301	6PGL: 6-Phosphogluconolactonase (6PGL) subfamily; 6PGL catalyzes the second step of the oxidative phase of the pentose phosphate pathway, the hydrolyzation of 6-phosphoglucono-1,5-lactone (delta form) to 6-phosphogluconate. 6PGL is thought to guard...; Region: 6PGL; cd01400
430066001302	putative active site [active]
430066001303	glucose-6-phosphate 1-dehydrogenase; Validated; Region: PRK05722
430066001304	Glucose-6-phosphate dehydrogenase, NAD binding domain; Region: G6PD_N; pfam00479
430066001305	Glucose-6-phosphate dehydrogenase, C-terminal domain; Region: G6PD_C; pfam02781
430066001306	putative beta-ketoacyl acyl carrier protein [ACP] reductase (BKR), subgroup 3, classical (c) SDR; Region: BKR_3_SDR_c; cd05345
430066001307	3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK07231
430066001308	putative NAD(P) binding site [chemical binding]; other site
430066001309	active site
430066001310	drug efflux system protein MdtG; Provisional; Region: PRK09874
430066001311	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
430066001312	putative substrate translocation pore; other site
430066001313	Predicted membrane protein [Function unknown]; Region: COG4541
430066001314	Predicted branched-chain amino acid permease (azaleucine resistance) [Amino acid transport and metabolism]; Region: AzlC; COG1296
430066001315	Transcriptional regulators [Transcription]; Region: Lrp; COG1522
430066001316	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
430066001317	putative DNA binding site [nucleotide binding]; other site
430066001318	putative Zn2+ binding site [ion binding]; other site
430066001319	AsnC family; Region: AsnC_trans_reg; pfam01037
430066001320	Hint domain; Region: Hint_2; pfam13403
430066001321	Helix-turn-helix domains; Region: HTH; cl00088
430066001322	putative aminophosphonate oxidoreductase; Region: Phn_aa_oxid; TIGR03329
430066001323	Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665
430066001324	hypothetical protein; Reviewed; Region: PRK12275
430066001325	four helix bundle protein; Region: TIGR02436
430066001326	Glutamine synthetase [Amino acid transport and metabolism]; Region: GlnA; COG0174
430066001327	Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120
430066001328	Domain of unknown function (DUF1127); Region: DUF1127; cl02276
430066001329	Transcriptional regulator [Transcription]; Region: LysR; COG0583
430066001330	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
430066001331	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
430066001332	dimerization interface [polypeptide binding]; other site
430066001333	exodeoxyribonuclease VII large subunit; Reviewed; Region: xseA; PRK00286
430066001334	ExoVII_LU_OBF: A subfamily of OB folds corresponding to the N-terminal OB-fold domain of Escherichia coli exodeoxyribonuclease VII (ExoVII) large subunit. E. coli ExoVII is composed of two non-identical subunits. E. coli ExoVII is a...; Region: ExoVII_LU_OBF; cd04489
430066001335	generic binding surface II; other site
430066001336	generic binding surface I; other site
430066001337	Gamma-glutamylcysteine synthetase [Coenzyme metabolism]; Region: GshA; COG3572
430066001338	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1385
430066001339	RNA methyltransferase, RsmE family; Region: TIGR00046
430066001340	helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347
430066001341	MarR family; Region: MarR_2; pfam12802
430066001342	Fusaric acid resistance protein family; Region: FUSC; pfam04632
430066001343	Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515
430066001344	Protein of unknown function (DUF1656); Region: DUF1656; pfam07869
430066001345	Multidrug resistance efflux pump [Defense mechanisms]; Region: EmrA; COG1566
430066001346	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
430066001347	HlyD family secretion protein; Region: HlyD_3; pfam13437
430066001348	Metal binding protein TroA_a.  These proteins are predicted to function as initial receptors in ABC transport of metal ions in eubacteria. They belong to the TroA superfamily of helical backbone metal receptor proteins that share a distinct fold and...; Region: TroA_a; cd01148
430066001349	proposed F420-0 ABC transporter, periplasmic F420-0 binding protein; Region: F420-O_ABCperi; TIGR03868
430066001350	putative ligand binding residues [chemical binding]; other site
430066001351	iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577
430066001352	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550
430066001353	ABC-ATPase subunit  interface; other site
430066001354	dimer interface [polypeptide binding]; other site
430066001355	putative PBP binding regions; other site
430066001356	ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120
430066001357	ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214
430066001358	Walker A/P-loop; other site
430066001359	ATP binding site [chemical binding]; other site
430066001360	Q-loop/lid; other site
430066001361	ABC transporter signature motif; other site
430066001362	Walker B; other site
430066001363	D-loop; other site
430066001364	H-loop/switch region; other site
430066001365	Uncharacterized conserved protein [Function unknown]; Region: COG5476
430066001366	Protein of unknown function (DUF1485); Region: DUF1485; pfam07364
430066001367	MlrC C-terminus; Region: MlrC_C; pfam07171
430066001368	YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448
430066001369	homotrimer interaction site [polypeptide binding]; other site
430066001370	putative active site [active]
430066001371	ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395
430066001372	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
430066001373	dimer interface [polypeptide binding]; other site
430066001374	conserved gate region; other site
430066001375	putative PBP binding loops; other site
430066001376	ABC-ATPase subunit interface; other site
430066001377	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
430066001378	dimer interface [polypeptide binding]; other site
430066001379	conserved gate region; other site
430066001380	putative PBP binding loops; other site
430066001381	ABC-ATPase subunit interface; other site
430066001382	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547
430066001383	Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416
430066001384	3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653
430066001385	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
430066001386	NAD(P) binding site [chemical binding]; other site
430066001387	active site
430066001388	glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650
430066001389	The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301
430066001390	Walker A/P-loop; other site
430066001391	ATP binding site [chemical binding]; other site
430066001392	Q-loop/lid; other site
430066001393	ABC transporter signature motif; other site
430066001394	Walker B; other site
430066001395	D-loop; other site
430066001396	H-loop/switch region; other site
430066001397	TOBE domain; Region: TOBE; pfam03459
430066001398	Transcriptional regulators [Transcription]; Region: RpiR; COG1737
430066001399	Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418
430066001400	RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013
430066001401	putative active site [active]
430066001402	ABC-type proline/glycine betaine transport system, ATPase component [Amino acid transport and metabolism]; Region: ProV; COG4175
430066001403	ATP-binding cassette domain of the osmoprotectant proline/glycine betaine uptake system; Region: ABC_Pro_Gly_Betaine; cd03294
430066001404	Walker A/P-loop; other site
430066001405	ATP binding site [chemical binding]; other site
430066001406	Q-loop/lid; other site
430066001407	ABC transporter signature motif; other site
430066001408	Walker B; other site
430066001409	D-loop; other site
430066001410	H-loop/switch region; other site
430066001411	The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354
430066001412	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
430066001413	dimer interface [polypeptide binding]; other site
430066001414	conserved gate region; other site
430066001415	putative PBP binding loops; other site
430066001416	ABC-ATPase subunit interface; other site
430066001417	ABC-type proline/glycine betaine transport systems, periplasmic components [Amino acid transport and metabolism]; Region: ProX; COG2113
430066001418	Substrate binding domain of ABC-type glycine betaine transport system; Region: OpuAC; pfam04069
430066001419	Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697
430066001420	EamA-like transporter family; Region: EamA; pfam00892
430066001421	BA14K-like protein; Region: BA14K; pfam07886
430066001422	Alcohol dehydrogenase, class IV [Energy production and conversion]; Region: EutG; COG1454
430066001423	Iron-containing alcohol dehydrogenases-like, involved in the linear alkylbenzenesulfonate (LAS) degradation pathway; Region: Fe-ADH7; cd08192
430066001424	putative active site [active]
430066001425	metal binding site [ion binding]; metal-binding site
430066001426	Glutamine synthetase [Amino acid transport and metabolism]; Region: GlnA; COG0174
430066001427	Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120
430066001428	Predicted N-formylglutamate amidohydrolase [Amino acid transport and metabolism]; Region: COG3931
430066001429	Transcriptional regulators [Transcription]; Region: RpiR; COG1737
430066001430	Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418
430066001431	RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013
430066001432	putative active site [active]
430066001433	Uncharacterized NAD(FAD)-dependent dehydrogenases [General function prediction only]; Region: HcaD; COG0446
430066001434	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
430066001435	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
430066001436	Uncharacterized conserved small protein [Function unknown]; Region: COG5457
430066001437	glycine cleavage system aminomethyltransferase T; Provisional; Region: gcvT; PRK13579
430066001438	Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669
430066001439	Glycine cleavage H-protein. Glycine cleavage H-proteins are part of the glycine cleavage system (GCS) found in bacteria, archea and the mitochondria of eukaryotes. GCS is a multienzyme complex consisting of 4 different components (P-, H-, T- and...; Region: GCS_H; cd06848
430066001440	lipoyl attachment site [posttranslational modification]; other site
430066001441	glycine dehydrogenase; Provisional; Region: PRK05367
430066001442	Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321
430066001443	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
430066001444	catalytic residue [active]
430066001445	Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613
430066001446	tetramer interface [polypeptide binding]; other site
430066001447	pyridoxal 5'-phosphate binding site [chemical binding]; other site
430066001448	catalytic residue [active]
430066001449	leucine-responsive transcriptional regulator; Provisional; Region: PRK11169
430066001450	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
430066001451	putative DNA binding site [nucleotide binding]; other site
430066001452	putative Zn2+ binding site [ion binding]; other site
430066001453	AsnC family; Region: AsnC_trans_reg; pfam01037
430066001454	bifunctional proline dehydrogenase/pyrroline-5-carboxylate dehydrogenase; Reviewed; Region: PRK11905
430066001455	Proline dehydrogenase [Amino acid transport and metabolism]; Region: PutA; COG0506
430066001456	Delta(1)-pyrroline-5-carboxylate dehydrogenase, PutA; Region: ALDH_PutA-P5CDH; cd07125
430066001457	Glutamate binding site [chemical binding]; other site
430066001458	NAD binding site [chemical binding]; other site
430066001459	catalytic residues [active]
430066001460	2-aminoethylphosphonate ABC transporter substrate-binding protein; Provisional; Region: PRK15046
430066001461	ABC-type Fe3+ transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: AfuA; COG1840
430066001462	ABC-type Fe3+ transport system, permease component [Inorganic ion transport and metabolism]; Region: ThiP; COG1178
430066001463	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
430066001464	dimer interface [polypeptide binding]; other site
430066001465	conserved gate region; other site
430066001466	putative PBP binding loops; other site
430066001467	ABC-ATPase subunit interface; other site
430066001468	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
430066001469	dimer interface [polypeptide binding]; other site
430066001470	conserved gate region; other site
430066001471	putative PBP binding loops; other site
430066001472	ABC-ATPase subunit interface; other site
430066001473	ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842
430066001474	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
430066001475	Walker A/P-loop; other site
430066001476	ATP binding site [chemical binding]; other site
430066001477	Q-loop/lid; other site
430066001478	ABC transporter signature motif; other site
430066001479	Walker B; other site
430066001480	D-loop; other site
430066001481	H-loop/switch region; other site
430066001482	TOBE domain; Region: TOBE_2; pfam08402
430066001483	Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483
430066001484	Bacterial family of Mg++ dependent phosphatases, related to inositol monophosphatases. These enzymes may dephosphorylate inositol monophosphate or similar substrates; Region: Bacterial_IMPase_like_2; cd01643
430066001485	active site
430066001486	Uncharacterized enzyme involved in inositol metabolism [Carbohydrate transport and metabolism]; Region: IolB; COG3718
430066001487	Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082
430066001488	Acetolactate synthase [Amino acid transport and metabolism]; Region: COG3962
430066001489	Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035
430066001490	PYR/PP interface [polypeptide binding]; other site
430066001491	dimer interface [polypeptide binding]; other site
430066001492	TPP binding site [chemical binding]; other site
430066001493	Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205
430066001494	Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cl01629
430066001495	TPP-binding site [chemical binding]; other site
430066001496	Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524
430066001497	2-keto-3-deoxygluconate kinase (KdgK) phosphorylates 2-keto-3-deoxygluconate (KDG) to form 2-keto-3-deoxy-6-phosphogluconate (KDGP). KDG is the common intermediate product, that allows organisms to channel D-glucuronate and/or D-galacturinate into the...; Region: KdgK; cd01166
430066001498	substrate binding site [chemical binding]; other site
430066001499	ATP binding site [chemical binding]; other site
430066001500	Uncharacterized protein conserved in bacteria (DUF2090); Region: DUF2090; pfam09863
430066001501	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3892
430066001502	Transcriptional regulators [Transcription]; Region: RpiR; COG1737
430066001503	Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418
430066001504	RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013
430066001505	putative active site [active]
430066001506	Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673
430066001507	Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408
430066001508	Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894
430066001509	Protein of unknown function (DUF1612); Region: DUF1612; pfam07756
430066001510	HTH DNA binding domain; Region: HTH_13; pfam11972
430066001511	DNA-binding transcriptional regulator OxyR; Provisional; Region: PRK11151
430066001512	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
430066001513	The C-terminal substrate-binding domain of the LysR-type transcriptional regulator OxyR, a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_OxyR; cd08411
430066001514	dimerization interface [polypeptide binding]; other site
430066001515	Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450
430066001516	Peroxiredoxin (PRX) family, Typical 2-Cys PRX subfamily; PRXs are thiol-specific antioxidant (TSA) proteins, which confer a protective role in cells through its peroxidase activity by reducing hydrogen peroxide, peroxynitrite, and organic hydroperoxides; Region: PRX_Typ2cys; cd03015
430066001517	dimer interface [polypeptide binding]; other site
430066001518	decamer (pentamer of dimers) interface [polypeptide binding]; other site
430066001519	catalytic triad [active]
430066001520	peroxidatic and resolving cysteines [active]
430066001521	alkylhydroperoxidase, AhpD family; Region: ahpD; TIGR00777
430066001522	Carboxymuconolactone decarboxylase family; Region: CMD; pfam02627
430066001523	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
430066001524	metabolite-proton symporter; Region: 2A0106; TIGR00883
430066001525	putative substrate translocation pore; other site
430066001526	multicopper oxidase; Provisional; Region: PRK10965
430066001527	Multicopper oxidase; Region: Cu-oxidase_3; pfam07732
430066001528	Multicopper oxidase; Region: Cu-oxidase; pfam00394
430066001529	Multicopper oxidase; Region: Cu-oxidase_2; pfam07731
430066001530	Cu/Zn superoxide dismutase [Inorganic ion transport and metabolism]; Region: SodC; COG2032
430066001531	Copper/zinc superoxide dismutase (SOD). superoxide dismutases catalyse the conversion of superoxide radicals to molecular oxygen. Three evolutionarily distinct families of SODs are known, of which the copper/zinc-binding family is one. Defects in the...; Region: Cu-Zn_Superoxide_Dismutase; cd00305
430066001532	E-class dimer interface [polypeptide binding]; other site
430066001533	P-class dimer interface [polypeptide binding]; other site
430066001534	active site
430066001535	Cu2+ binding site [ion binding]; other site
430066001536	Zn2+ binding site [ion binding]; other site
430066001537	FAD dependent oxidoreductase; Region: DAO; pfam01266
430066001538	hydroxyglutarate oxidase; Provisional; Region: PRK11728
430066001539	ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842
430066001540	ATP-binding cassette domain of the carbohydrate and solute transporters-like; Region: ABC_Carb_Solutes_like; cd03259
430066001541	Walker A/P-loop; other site
430066001542	ATP binding site [chemical binding]; other site
430066001543	Q-loop/lid; other site
430066001544	ABC transporter signature motif; other site
430066001545	Walker B; other site
430066001546	D-loop; other site
430066001547	H-loop/switch region; other site
430066001548	ABC-type Fe3+ transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: AfuA; COG1840
430066001549	Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416
430066001550	ABC-type Fe3+ transport system, permease component [Inorganic ion transport and metabolism]; Region: ThiP; COG1178
430066001551	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
430066001552	dimer interface [polypeptide binding]; other site
430066001553	conserved gate region; other site
430066001554	putative PBP binding loops; other site
430066001555	ABC-ATPase subunit interface; other site
430066001556	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
430066001557	dimer interface [polypeptide binding]; other site
430066001558	conserved gate region; other site
430066001559	putative PBP binding loops; other site
430066001560	ABC-ATPase subunit interface; other site
430066001561	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3453
430066001562	formate dehydrogenase accessory protein; Reviewed; Region: PRK00724
430066001563	lumazine synthase (6,7-dimethyl-8-ribityllumazine synthase, LS), catalyzes the penultimate step in the biosynthesis of riboflavin (vitamin B2); type-II; Region: Lumazine_synthase-II; cd09208
430066001564	active site
430066001565	homopentamer interface [polypeptide binding]; other site
430066001566	dimer interface [polypeptide binding]; other site
430066001567	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653
430066001568	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547
430066001569	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
430066001570	dimer interface [polypeptide binding]; other site
430066001571	conserved gate region; other site
430066001572	putative PBP binding loops; other site
430066001573	ABC-ATPase subunit interface; other site
430066001574	glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650
430066001575	The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301
430066001576	Walker A/P-loop; other site
430066001577	ATP binding site [chemical binding]; other site
430066001578	Q-loop/lid; other site
430066001579	ABC transporter signature motif; other site
430066001580	Walker B; other site
430066001581	D-loop; other site
430066001582	H-loop/switch region; other site
430066001583	TOBE domain; Region: TOBE_2; pfam08402
430066001584	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
430066001585	putative transporter; Provisional; Region: PRK10504
430066001586	putative substrate translocation pore; other site
430066001587	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
430066001588	23S rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: FtsJ; COG0293
430066001589	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
430066001590	S-adenosylmethionine binding site [chemical binding]; other site
430066001591	exopolyphosphatase; Region: exo_poly_only; TIGR03706
430066001592	Ppx/GppA phosphatase family; Region: Ppx-GppA; pfam02541
430066001593	ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126
430066001594	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
430066001595	Walker A/P-loop; other site
430066001596	ATP binding site [chemical binding]; other site
430066001597	Q-loop/lid; other site
430066001598	ABC transporter signature motif; other site
430066001599	Walker B; other site
430066001600	D-loop; other site
430066001601	H-loop/switch region; other site
430066001602	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
430066001603	dimer interface [polypeptide binding]; other site
430066001604	conserved gate region; other site
430066001605	putative PBP binding loops; other site
430066001606	ABC-ATPase subunit interface; other site
430066001607	Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497
430066001608	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
430066001609	substrate binding pocket [chemical binding]; other site
430066001610	membrane-bound complex binding site; other site
430066001611	hinge residues; other site
430066001612	5-oxoprolinase; Region: PLN02666
430066001613	Hydantoinase/oxoprolinase N-terminal region; Region: Hydant_A_N; pfam05378
430066001614	Hydantoinase/oxoprolinase; Region: Hydantoinase_A; pfam01968
430066001615	N-methylhydantoinase B/acetone carboxylase, alpha subunit [Amino acid transport and metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: HyuB; COG0146
430066001616	Predicted transcription regulator, contains HTH domain (MarR family) [Transcription]; Region: COG5631
430066001617	ABC-type enterochelin transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CeuD; COG4604
430066001618	ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214
430066001619	Walker A/P-loop; other site
430066001620	ATP binding site [chemical binding]; other site
430066001621	Q-loop/lid; other site
430066001622	ABC transporter signature motif; other site
430066001623	Walker B; other site
430066001624	D-loop; other site
430066001625	H-loop/switch region; other site
430066001626	ABC-type enterochelin transport system, permease component [Inorganic ion transport and metabolism]; Region: CeuC; COG4605
430066001627	ABC-ATPase subunit  interface; other site
430066001628	dimer interface [polypeptide binding]; other site
430066001629	putative PBP binding regions; other site
430066001630	iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577
430066001631	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550
430066001632	ABC-ATPase subunit  interface; other site
430066001633	dimer interface [polypeptide binding]; other site
430066001634	putative PBP binding regions; other site
430066001635	Siderophore binding protein FatB.  These proteins have been shown to function as ABC-type initial receptors in the siderophore-mediated iron uptake in some eubacterial species.  They belong to the TroA superfamily of periplasmic metal binding proteins...; Region: FatB; cd01140
430066001636	Periplasmic binding protein; Region: Peripla_BP_2; pfam01497
430066001637	putative ligand binding residues [chemical binding]; other site
430066001638	Rhodococcus ruber 6-oxolauric acid dehydrogenase-like; Region: ALDH_CddD_SSP0762; cd07138
430066001639	Aldehyde dehydrogenase family; Region: Aldedh; pfam00171
430066001640	NAD binding site [chemical binding]; other site
430066001641	catalytic residues [active]
430066001642	putative FAD-binding dehydrogenase; Reviewed; Region: PRK12834
430066001643	FAD binding domain; Region: FAD_binding_2; pfam00890
430066001644	Sulfite exporter TauE/SafE; Region: TauE; pfam01925
430066001645	aminotransferase; Provisional; Region: PRK13356
430066001646	Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115
430066001647	homodimer interface [polypeptide binding]; other site
430066001648	substrate-cofactor binding pocket; other site
430066001649	pyridoxal 5'-phosphate binding site [chemical binding]; other site
430066001650	catalytic residue [active]
430066001651	Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697
430066001652	EamA-like transporter family; Region: EamA; pfam00892
430066001653	Protein of unknown function (DUF2938); Region: DUF2938; pfam11158
430066001654	Xanthine/uracil/vitamin C permease [Nucleotide transport and    metabolism]; Region: COG2252
430066001655	Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285
430066001656	nucleoside/Zn binding site; other site
430066001657	dimer interface [polypeptide binding]; other site
430066001658	catalytic motif [active]
430066001659	Anion permease ArsB/NhaD.  These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life.  A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl17221
430066001660	transmembrane helices; other site
430066001661	TrkA-C domain; Region: TrkA_C; pfam02080
430066001662	Putative regulatory, ligand-binding protein related to C-terminal domains of K+ channels [Inorganic ion transport and metabolism]; Region: COG0490
430066001663	TrkA-C domain; Region: TrkA_C; pfam02080
430066001664	Permease SLC13 (solute carrier 13).  The sodium/dicarboxylate cotransporter NaDC-1 has been shown to translocate Krebs cycle intermediates such as succinate, citrate, and alpha-ketoglutarate across plasma membranes rabbit, human, and rat kidney. It is...; Region: SLC13_permease; cd01115
430066001665	glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650
430066001666	The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301
430066001667	Walker A/P-loop; other site
430066001668	ATP binding site [chemical binding]; other site
430066001669	Q-loop/lid; other site
430066001670	ABC transporter signature motif; other site
430066001671	Walker B; other site
430066001672	D-loop; other site
430066001673	H-loop/switch region; other site
430066001674	TOBE domain; Region: TOBE_2; pfam08402
430066001675	ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395
430066001676	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
430066001677	dimer interface [polypeptide binding]; other site
430066001678	conserved gate region; other site
430066001679	ABC-ATPase subunit interface; other site
430066001680	ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555
430066001681	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427
430066001682	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653
430066001683	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199
430066001684	Zn-dependent dipeptidase, microsomal dipeptidase homolog [Amino acid transport and metabolism]; Region: COG2355
430066001685	renal dipeptidase (rDP), best studied in mammals and also called membrane or microsomal dipeptidase, is a membrane-bound glycoprotein hydrolyzing dipeptides and is involved in hydrolytic metabolism of penem and carbapenem beta-lactam antibiotics; Region: rDP_like; cd01301
430066001686	active site
430066001687	dimer interface [polypeptide binding]; other site
430066001688	Adenine deaminase [Nucleotide transport and metabolism]; Region: AdeC; COG1001
430066001689	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
430066001690	Adenine deaminase (AdeC) directly deaminates adenine to form hypoxanthine. This reaction is part of one of the adenine salvage pathways, as well as the degradation pathway. It is important for adenine utilization as a purine, as well as a nitrogen source...; Region: AdeC; cd01295
430066001691	active site
430066001692	ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410
430066001693	ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224
430066001694	Walker A/P-loop; other site
430066001695	ATP binding site [chemical binding]; other site
430066001696	Q-loop/lid; other site
430066001697	ABC transporter signature motif; other site
430066001698	Walker B; other site
430066001699	D-loop; other site
430066001700	H-loop/switch region; other site
430066001701	ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411
430066001702	ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219
430066001703	Walker A/P-loop; other site
430066001704	ATP binding site [chemical binding]; other site
430066001705	Q-loop/lid; other site
430066001706	ABC transporter signature motif; other site
430066001707	Walker B; other site
430066001708	D-loop; other site
430066001709	H-loop/switch region; other site
430066001710	ABC-type branched-chain amino acid transport system, permease component [Amino acid transport and metabolism]; Region: LivM; COG4177
430066001711	Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581
430066001712	TM-ABC transporter signature motif; other site
430066001713	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
430066001714	Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582
430066001715	TM-ABC transporter signature motif; other site
430066001716	ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683
430066001717	Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011
430066001718	3-carboxy-cis,cis-muconate cycloisomerase; Provisional; Region: PRK05975
430066001719	Adenylosuccinate lyase [Nucleotide transport and metabolism]; Region: PurB; COG0015
430066001720	tetramer interface [polypeptide binding]; other site
430066001721	Protocatechuate 3,4-dioxygenase beta subunit [Secondary metabolites biosynthesis, transport, and catabolism]; Region: PcaH; COG3485
430066001722	Protocatechuate 3,4-dioxygenase (3,4-PCD) , alpha subunit. 3,4-PCD catalyzes the oxidative ring cleavage of 3,4-dihydroxybenzoate to produce beta-carboxy-cis,cis-muconate. 3,4-PCDs are large aggregates of 12 protomers, each composed of an alpha- and...; Region: 3,4-PCD_alpha; cd03463
430066001723	heterodimer interface [polypeptide binding]; other site
430066001724	active site
430066001725	Intradiol dioxygenases catalyze the critical ring-cleavage step in the conversion of catecholate derivatives to citric acid cycle intermediates. This family contains catechol 1,2-dioxygenases and protocatechuate 3,4-dioxygenases which are mononuclear...; Region: intradiol_dioxygenase; cl17208
430066001726	protocatechuate 3,4-dioxygenase, beta subunit; Region: protocat_beta; TIGR02422
430066001727	active site
430066001728	4-carboxymuconolactone decarboxylase; Region: decarb_PcaC; TIGR02425
430066001729	3-oxoadipate enol-lactonase; Region: protocat_pcaD; TIGR02427
430066001730	pca operon transcription factor PcaQ; Region: TF_pcaQ; TIGR02424
430066001731	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
430066001732	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
430066001733	dimerization interface [polypeptide binding]; other site
430066001734	4-hydroxybenzoate 3-monooxygenase; Validated; Region: PRK08243
430066001735	Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912
430066001736	4-hydroxyphenylacetate catabolism regulatory protein HpaA; Region: HpaA; TIGR02297
430066001737	Cupin domain; Region: Cupin_2; cl17218
430066001738	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
430066001739	beta-ketoadipate pathway transcriptional regulators, PcaR/PcaU/PobR family; Region: pcaR_pcaU; TIGR02431
430066001740	helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346
430066001741	Bacterial transcriptional regulator; Region: IclR; pfam01614
430066001742	3-oxoacid CoA-transferase, A subunit; Region: pcaI_scoA_fam; TIGR02429
430066001743	3-oxoacid CoA-transferase, B subunit; Region: pcaJ_scoB_fam; TIGR02428
430066001744	beta-ketoadipyl CoA thiolase; Validated; Region: PRK09050
430066001745	Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751
430066001746	dimer interface [polypeptide binding]; other site
430066001747	active site
430066001748	Predicted metal-dependent hydrolase with the TIM-barrel fold [General function prediction only]; Region: COG1574
430066001749	YtcJ_like metal dependent amidohydrolases. YtcJ is a Bacillus subtilis ORF of unknown function. The Arabidopsis homolog LAF3 has been identified as a factor required for photochrome A signalling; Region: YtcJ_like; cd01300
430066001750	active site
430066001751	AsnC family; Region: AsnC_trans_reg; pfam01037
430066001752	Saccharopine dehydrogenase and related proteins [Amino acid transport and metabolism]; Region: LYS9; COG1748
430066001753	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
430066001754	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
430066001755	Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497
430066001756	substrate binding pocket [chemical binding]; other site
430066001757	membrane-bound complex binding site; other site
430066001758	hinge residues; other site
430066001759	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
430066001760	Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497
430066001761	substrate binding pocket [chemical binding]; other site
430066001762	membrane-bound complex binding site; other site
430066001763	hinge residues; other site
430066001764	Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665
430066001765	hydroxyglutarate oxidase; Provisional; Region: PRK11728
430066001766	hydroxyglutarate oxidase; Provisional; Region: PRK11728
430066001767	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
430066001768	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
430066001769	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
430066001770	DNA polymerase III, epsilon subunit and related 3'-5' exonucleases [DNA replication, recombination, and repair]; Region: DnaQ; COG0847
430066001771	DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127
430066001772	active site
430066001773	catalytic site [active]
430066001774	substrate binding site [chemical binding]; other site
430066001775	Pyrimidine dimer DNA glycosylase; Region: Pyr_excise; pfam03013
430066001776	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
430066001777	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
430066001778	I-site; other site
430066001779	active site
430066001780	metal binding site [ion binding]; metal-binding site
430066001781	Esterase-like activity of phytase; Region: Phytase-like; pfam13449
430066001782	DNA polymerase IV; Provisional; Region: PRK02794
430066001783	DNA Polymerase IV/Kappa; Region: PolY_Pol_IV_kappa; cd03586
430066001784	active site
430066001785	DNA binding site [nucleotide binding]
430066001786	nucleoside diphosphate kinase regulator; Provisional; Region: PRK05753
430066001787	Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272
430066001788	Protein of unknown function (DUF3572); Region: DUF3572; pfam12096
430066001789	FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784
430066001790	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
430066001791	active site
430066001792	phosphorylation site [posttranslational modification]
430066001793	intermolecular recognition site; other site
430066001794	dimerization interface [polypeptide binding]; other site
430066001795	response regulator PleD; Reviewed; Region: pleD; PRK09581
430066001796	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
430066001797	active site
430066001798	phosphorylation site [posttranslational modification]
430066001799	intermolecular recognition site; other site
430066001800	dimerization interface [polypeptide binding]; other site
430066001801	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
430066001802	active site
430066001803	phosphorylation site [posttranslational modification]
430066001804	intermolecular recognition site; other site
430066001805	dimerization interface [polypeptide binding]; other site
430066001806	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
430066001807	metal binding site [ion binding]; metal-binding site
430066001808	active site
430066001809	I-site; other site
430066001810	50S ribosomal protein L33; Validated; Region: rpmG; PRK00595
430066001811	Major Facilitator Superfamily; Region: MFS_1; pfam07690
430066001812	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
430066001813	putative substrate translocation pore; other site
430066001814	hypothetical protein; Provisional; Region: PRK05978
430066001815	ribonuclease R; Region: RNase_R; TIGR02063
430066001816	RNB domain; Region: RNB; pfam00773
430066001817	S1_RNase_R: RNase R C-terminal S1 domain. RNase R is a processive 3' to 5' exoribonuclease, which is a homolog of RNase II. RNase R degrades RNA with secondary structure having a 3' overhang of at least 7 nucleotides. RNase R and PNPase...; Region: S1_RNase_R; cd04471
430066001818	RNA binding site [nucleotide binding]; other site
430066001819	DNA topoisomerase I; Validated; Region: PRK06599
430066001820	Topoisomerase-primase domain. This is a nucleotidyl transferase/hydrolase domain found in type IA, type IIA and type IIB topoisomerases, bacterial DnaG-type primases, small primase-like proteins from bacteria and archaea, OLD family nucleases from...; Region: TOPRIM; cl00718
430066001821	active site
430066001822	metal binding site [ion binding]; metal-binding site
430066001823	DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186
430066001824	domain I; other site
430066001825	DNA binding groove [nucleotide binding]
430066001826	phosphate binding site [ion binding]; other site
430066001827	domain II; other site
430066001828	domain III; other site
430066001829	nucleotide binding site [chemical binding]; other site
430066001830	catalytic site [active]
430066001831	domain IV; other site
430066001832	Uncharacterized C-terminal domain of topoisomerase IA [General function prediction only]; Region: COG1754
430066001833	Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396
430066001834	Topoisomerase C-terminal repeat; Region: Toprim_C_rpt; pfam13368
430066001835	Topoisomerase C-terminal repeat; Region: Toprim_C_rpt; pfam13368
430066001836	Topoisomerase C-terminal repeat; Region: Toprim_C_rpt; pfam13368
430066001837	Predicted Rossmann fold nucleotide-binding protein involved in DNA uptake [DNA replication, recombination, and repair / Intracellular trafficking and secretion]; Region: Smf; COG0758
430066001838	DNA protecting protein DprA; Region: dprA; TIGR00732
430066001839	putative glycerol-3-phosphate acyltransferase PlsY; Provisional; Region: PRK00220
430066001840	dihydroorotase; Validated; Region: PRK09059
430066001841	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
430066001842	Dihydroorotase (DHOase), subgroup IIa; DHOases catalyze the reversible interconversion of carbamoyl aspartate to dihydroorotate, a key reaction in pyrimidine biosynthesis. This subgroup also contains proteins that lack the active site, like unc-33, a C; Region: DHOase_IIa; cd01317
430066001843	active site
430066001844	aspartate carbamoyltransferase catalytic subunit; Provisional; Region: pyrB; PRK00856
430066001845	Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729
430066001846	Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185
430066001847	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
430066001848	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
430066001849	active site
430066001850	Predicted endonuclease involved in recombination (possible Holliday junction resolvase in Mycoplasmas and B. subtilis) [DNA replication, recombination, and repair]; Region: COG0816
430066001851	Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220
430066001852	metal-dependent hydrolase; Provisional; Region: PRK00685
430066001853	aspartyl/glutamyl-tRNA amidotransferase subunit C; Reviewed; Region: gatC; PRK00034
430066001854	Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154
430066001855	aspartyl/glutamyl-tRNA amidotransferase subunit A; Reviewed; Region: gatA; PRK00012
430066001856	DNA topoisomerase IV subunit B; Reviewed; Region: PRK05559
430066001857	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
430066001858	Mg2+ binding site [ion binding]; other site
430066001859	G-X-G motif; other site
430066001860	TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822
430066001861	anchoring element; other site
430066001862	dimer interface [polypeptide binding]; other site
430066001863	ATP binding site [chemical binding]; other site
430066001864	Topoisomerase-primase domain. This is a nucleotidyl transferase/hydrolase domain found in type IA, type IIA and type IIB topoisomerases, bacterial DnaG-type primases, small primase-like proteins from bacteria and archaea, OLD family nucleases from...; Region: TOPRIM; cl00718
430066001865	active site
430066001866	metal binding site [ion binding]; metal-binding site
430066001867	DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986
430066001868	Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697
430066001869	EamA-like transporter family; Region: EamA; pfam00892
430066001870	lipoate-protein ligase B; Provisional; Region: PRK14341
430066001871	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
430066001872	PAS domain; Region: PAS_9; pfam13426
430066001873	putative active site [active]
430066001874	heme pocket [chemical binding]; other site
430066001875	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
430066001876	PAS fold; Region: PAS_3; pfam08447
430066001877	putative active site [active]
430066001878	heme pocket [chemical binding]; other site
430066001879	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920
430066001880	HWE histidine kinase; Region: HWE_HK; pfam07536
430066001881	BA14K-like protein; Region: BA14K; pfam07886
430066001882	Type IV secretory pathway, VirJ component [Intracellular trafficking and secretion]; Region: VirJ; COG3946
430066001883	Bacterial virulence protein (VirJ); Region: VirJ; pfam06057
430066001884	Predicted integral membrane protein [Function unknown]; Region: COG0392
430066001885	Uncharacterized conserved protein [Function unknown]; Region: COG2898
430066001886	Uncharacterized conserved protein (DUF2156); Region: DUF2156; pfam09924
430066001887	Cytochrome c biogenesis protein [Posttranslational modification, protein turnover, chaperones]; Region: CcdA; COG0785
430066001888	Cytochrome C biogenesis protein transmembrane region; Region: DsbD; cl15788
430066001889	bifunctional N-acetylglucosamine-1-phosphate uridyltransferase/glucosamine-1-phosphate acetyltransferase; Provisional; Region: glmU; PRK14353
430066001890	N-terminal domain of bacterial GlmU; Region: GT2_GlmU_N_bac; cd02540
430066001891	Substrate binding site; other site
430066001892	Mg++ binding site; other site
430066001893	N-acetyl-glucosamine-1-phosphate uridyltransferase (GlmU), C-terminal left-handed beta-helix (LbH) acetyltransferase domain: GlmU is also known as UDP-N-acetylglucosamine pyrophosphorylase. It is a bifunctional bacterial enzyme that catalyzes two...; Region: LbH_GlmU_C; cd03353
430066001894	active site
430066001895	substrate binding site [chemical binding]; other site
430066001896	CoA binding site [chemical binding]; other site
430066001897	glucosamine--fructose-6-phosphate aminotransferase; Reviewed; Region: PRK00331
430066001898	Glutamine amidotransferases class-II (Gn-AT)_GFAT-type. This domain is found at the N-terminus of glucosamine-6P synthase (GlmS, or GFAT in humans).  The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the appropriate substrate. In...; Region: GFAT; cd00714
430066001899	glutaminase active site [active]
430066001900	SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008
430066001901	dimer interface [polypeptide binding]; other site
430066001902	active site
430066001903	SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009
430066001904	dimer interface [polypeptide binding]; other site
430066001905	active site
430066001906	RecG-like helicase [DNA replication, recombination, and repair / Transcription]; Region: RecG; COG1200
430066001907	RecG_wedge_OBF: A subfamily of OB folds corresponding to the OB fold found in the N-terminal (wedge) domain of Escherichia coli RecG. RecG is a branched-DNA-specific helicase, which catalyzes the interconversion of a DNA replication fork to a...; Region: RecG_wedge_OBF; cd04488
430066001908	generic binding surface II; other site
430066001909	ssDNA binding site; other site
430066001910	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
430066001911	ATP binding site [chemical binding]; other site
430066001912	putative Mg++ binding site [ion binding]; other site
430066001913	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
430066001914	nucleotide binding region [chemical binding]; other site
430066001915	ATP-binding site [chemical binding]; other site
430066001916	Uncharacterized conserved protein [Function unknown]; Region: COG2938
430066001917	Transcription-repair coupling factor (superfamily II helicase) [DNA replication, recombination, and repair / Transcription]; Region: Mfd; COG1197
430066001918	CarD-like/TRCF domain; Region: CarD_TRCF; smart01058
430066001919	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
430066001920	ATP binding site [chemical binding]; other site
430066001921	putative Mg++ binding site [ion binding]; other site
430066001922	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
430066001923	nucleotide binding region [chemical binding]; other site
430066001924	ATP-binding site [chemical binding]; other site
430066001925	This domain is found in proteins necessary for strand-specific repair in DNA such as TRCF in Escherichia coli; Region: TRCF; smart00982
430066001926	This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632
430066001927	active site
430066001928	Predicted dithiol-disulfide isomerase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: FrnE; COG2761
430066001929	DsbA family, FrnE subfamily; FrnE is a DsbA-like protein containing a CXXC motif. It is presumed to be a thiol oxidoreductase involved in polyketide biosynthesis, specifically in the production of the aromatic antibiotics frenolicin and nanaomycins; Region: DsbA_FrnE; cd03024
430066001930	catalytic residues [active]
430066001931	ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166
430066001932	The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_14; cd08497
430066001933	Invasion protein B, involved in pathogenesis [General function prediction only]; Region: COG5342
430066001934	Uncharacterized conserved protein [Function unknown]; Region: COG3785
430066001935	2-octaprenyl-6-methoxyphenyl hydroxylase; Provisional; Region: PRK07494
430066001936	ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314
430066001937	Phosphatidylserine synthase [Lipid metabolism]; Region: PssA; COG1183
430066001938	CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; pfam01066
430066001939	Quinone oxidoreductase (QOR); Region: QOR2; cd05286
430066001940	NADP binding site [chemical binding]; other site
430066001941	ABC-type uncharacterized transport systems, ATPase components [General function prediction only]; Region: COG3845
430066001942	First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216
430066001943	Walker A/P-loop; other site
430066001944	ATP binding site [chemical binding]; other site
430066001945	Q-loop/lid; other site
430066001946	ABC transporter signature motif; other site
430066001947	Walker B; other site
430066001948	D-loop; other site
430066001949	H-loop/switch region; other site
430066001950	Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215
430066001951	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
430066001952	Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette; Region: TM_PBP1_transp_TpRbsC_like; cd06580
430066001953	TM-ABC transporter signature motif; other site
430066001954	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
430066001955	Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette; Region: TM_PBP1_transp_TpRbsC_like; cd06580
430066001956	TM-ABC transporter signature motif; other site
430066001957	Uncharacterized ABC-type transport system, periplasmic component/surface lipoprotein [General function prediction only]; Region: Med; COG1744
430066001958	Periplasmic binding domain of the basic membrane lipoprotein Med in Bacillus and its close homologs from other bacteria and Archaea; Region: PBP1_BmpA_Med_like; cd06353
430066001959	putative ligand binding site [chemical binding]; other site
430066001960	ribosomal protein S12 methylthiotransferase; Provisional; Region: rimO; PRK14862
430066001961	Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919
430066001962	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
430066001963	FeS/SAM binding site; other site
430066001964	Bacterioferritin (cytochrome b1) [Inorganic ion transport and metabolism]; Region: Bfr; COG2193
430066001965	Bacterioferritin, ferritin-like diiron-binding domain; Region: Bacterioferritin; cd00907
430066001966	heme binding site [chemical binding]; other site
430066001967	ferroxidase pore; other site
430066001968	ferroxidase diiron center [ion binding]; other site
430066001969	Uncharacterized enzyme involved in biosynthesis of extracellular polysaccharides [General function prediction only]; Region: COG2329
430066001970	iron-responsive transcriptional regulator; Reviewed; Region: rirA; PRK11920
430066001971	Predicted transcriptional regulator [Transcription]; Region: COG1959
430066001972	This CD, composed mainly of bacterial single-domain proteins, includes the Thermus thermophilus (Tt) YbaK-like protein, a homolog of the trans-acting Escherichia coli YbaK Cys-tRNA(Pro) deacylase and the Agrobacterium tumefaciens  ProX Ala-tRNA(Pro)...; Region: ProX_deacylase; cd04333
430066001973	putative deacylase active site [active]
430066001974	Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340
430066001975	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963
430066001976	Transposase; Region: HTH_Tnp_1; pfam01527
430066001977	IS66 Orf2 like protein; Region: TnpB_IS66; pfam05717
430066001978	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436
430066001979	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436
430066001980	putative Helix-turn-helix domain of transposase IS66; Region: HTH_Tnp_IS66; pfam13005
430066001981	Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050
430066001982	IS66 C-terminal element; Region: DDE_Tnp_IS66_C; pfam13817
430066001983	yecA family protein; Region: ygfB_yecA; TIGR02292
430066001984	Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586
430066001985	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
430066001986	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
430066001987	Protein of unknown function (DUF995); Region: DUF995; pfam06191
430066001988	Beta-mannanase [Carbohydrate transport and metabolism]; Region: ManB; COG4124
430066001989	Protein of unknown function (DUF995); Region: DUF995; pfam06191
430066001990	Predicted UDP-glucose 6-dehydrogenase [Cell envelope biogenesis, outer membrane]; Region: Ugd; COG1004
430066001991	NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210
430066001992	UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984
430066001993	UDP binding domain; Region: UDPG_MGDP_dh_C; smart00984
430066001994	Glycosyltransferases, probably involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: COG1215
430066001995	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
430066001996	active site
430066001997	Cellulose synthase-like protein; Region: PLN02893
430066001998	UDP-glucose 4-epimerase [Cell envelope biogenesis, outer membrane]; Region: GalE; COG1087
430066001999	UDP-glucose 4 epimerase, subgroup 1, extended (e) SDRs; Region: UDP_G4E_1_SDR_e; cd05247
430066002000	NAD binding site [chemical binding]; other site
430066002001	homodimer interface [polypeptide binding]; other site
430066002002	active site
430066002003	substrate binding site [chemical binding]; other site
430066002004	Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451
430066002005	UDP-glucuronate decarboxylase (UGD) and related proteins, extended (e) SDRs; Region: UGD_SDR_e; cd05230
430066002006	NAD binding site [chemical binding]; other site
430066002007	putative substrate binding site 2 [chemical binding]; other site
430066002008	putative substrate binding site 1 [chemical binding]; other site
430066002009	active site
430066002010	Predicted integral membrane protein [Function unknown]; Region: COG5455
430066002011	ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166
430066002012	The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504
430066002013	peptide binding site [polypeptide binding]; other site
430066002014	ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166
430066002015	The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504
430066002016	peptide binding site [polypeptide binding]; other site
430066002017	oligopeptide transporter permease; Reviewed; Region: oppB; PRK09471
430066002018	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
430066002019	dimer interface [polypeptide binding]; other site
430066002020	conserved gate region; other site
430066002021	putative PBP binding loops; other site
430066002022	ABC-ATPase subunit interface; other site
430066002023	N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911
430066002024	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
430066002025	dimer interface [polypeptide binding]; other site
430066002026	conserved gate region; other site
430066002027	ABC-ATPase subunit interface; other site
430066002028	ABC-type uncharacterized transport system, duplicated ATPase component [General function prediction only]; Region: COG4172
430066002029	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
430066002030	Walker A/P-loop; other site
430066002031	ATP binding site [chemical binding]; other site
430066002032	Q-loop/lid; other site
430066002033	ABC transporter signature motif; other site
430066002034	Walker B; other site
430066002035	D-loop; other site
430066002036	H-loop/switch region; other site
430066002037	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; pfam08352
430066002038	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
430066002039	Walker A/P-loop; other site
430066002040	ATP binding site [chemical binding]; other site
430066002041	Q-loop/lid; other site
430066002042	ABC transporter signature motif; other site
430066002043	Walker B; other site
430066002044	D-loop; other site
430066002045	H-loop/switch region; other site
430066002046	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097
430066002047	alpha-ketoglutarate-dependent dioxygenase AlkB; Provisional; Region: PRK15401
430066002048	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3293
430066002049	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
430066002050	Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340
430066002051	benzoate transport; Region: 2A0115; TIGR00895
430066002052	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
430066002053	putative substrate translocation pore; other site
430066002054	L-Aminopeptidase D-amidase/D-esterase (DmpA) family; DmpA catalyzes the release of N-terminal D and L amino acids from peptide susbtrates. DmpA is synthesized as a single polypeptide precursor, which is autocatalytically cleaved to the active...; Region: DmpA; cd02253
430066002055	homodimer interface [polypeptide binding]; other site
430066002056	homotetramer interface [polypeptide binding]; other site
430066002057	active site pocket [active]
430066002058	cleavage site
430066002059	DNA segregation ATPase FtsK/SpoIIIE and related proteins [Cell division and chromosome partitioning]; Region: FtsK; COG1674
430066002060	FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580
430066002061	Ftsk gamma domain; Region: Ftsk_gamma; pfam09397
430066002062	SURF1 superfamily. Surf1/Shy1 has been implicated in the posttranslational steps of the biogenesis of the mitochondrially-encoded Cox1 subunit of cytochrome c oxidase (complex IV). Cytochrome c oxidase (complex IV), the terminal electron-transferring...; Region: SURF1; cd06662
430066002063	dihydrolipoamide dehydrogenase; Validated; Region: PRK05976
430066002064	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
430066002065	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
430066002066	Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852
430066002067	branched-chain alpha-keto acid dehydrogenase subunit E2; Reviewed; Region: PRK11856
430066002068	Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849
430066002069	E3 interaction surface; other site
430066002070	lipoyl attachment site [posttranslational modification]; other site
430066002071	e3 binding domain; Region: E3_binding; pfam02817
430066002072	2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198
430066002073	Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit [Energy production and conversion]; Region: AcoB; COG0022
430066002074	Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036
430066002075	alpha subunit interface [polypeptide binding]; other site
430066002076	TPP binding site [chemical binding]; other site
430066002077	heterodimer interface [polypeptide binding]; other site
430066002078	Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780
430066002079	2-oxoisovalerate dehydrogenase E1 alpha subunit N terminal; Region: OxoDH_E1alpha_N; pfam12573
430066002080	Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, alpha subunit [Energy production and conversion]; Region: AcoA; COG1071
430066002081	Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000
430066002082	tetramer interface [polypeptide binding]; other site
430066002083	TPP-binding site [chemical binding]; other site
430066002084	heterodimer interface [polypeptide binding]; other site
430066002085	phosphorylation loop region [posttranslational modification]
430066002086	ABC-type sugar transport systems, ATPase components [Carbohydrate transport and metabolism]; Region: MalK; COG3839
430066002087	The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301
430066002088	Walker A/P-loop; other site
430066002089	ATP binding site [chemical binding]; other site
430066002090	Q-loop/lid; other site
430066002091	ABC transporter signature motif; other site
430066002092	Walker B; other site
430066002093	D-loop; other site
430066002094	H-loop/switch region; other site
430066002095	TOBE domain; Region: TOBE_2; pfam08402
430066002096	Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673
430066002097	Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408
430066002098	ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395
430066002099	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
430066002100	dimer interface [polypeptide binding]; other site
430066002101	conserved gate region; other site
430066002102	putative PBP binding loops; other site
430066002103	ABC-ATPase subunit interface; other site
430066002104	ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555
430066002105	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
430066002106	dimer interface [polypeptide binding]; other site
430066002107	conserved gate region; other site
430066002108	putative PBP binding loops; other site
430066002109	ABC-ATPase subunit interface; other site
430066002110	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653
430066002111	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547
430066002112	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653
430066002113	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547
430066002114	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012
430066002115	nucleotide binding site [chemical binding]; other site
430066002116	Transcriptional regulators [Transcription]; Region: PhnF; COG2188
430066002117	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
430066002118	DNA-binding site [nucleotide binding]; DNA binding site
430066002119	UTRA domain; Region: UTRA; pfam07702
430066002120	Predicted outer membrane lipoprotein [Function unknown]; Region: COG4890
430066002121	cytochrome d ubiquinol oxidase subunit 2; Provisional; Region: PRK15003; cl12219
430066002122	Cytochrome oxidase subunit II; Region: Cyto_ox_2; pfam02322
430066002123	cytochrome d terminal oxidase subunit 1; Provisional; Region: PRK15097
430066002124	Bacterial Cytochrome Ubiquinol Oxidase; Region: Bac_Ubq_Cox; cl00562
430066002125	ABC-type transport system involved in cytochrome bd biosynthesis, fused ATPase and permease components [Energy production and conversion / Posttranslational modification, protein turnover, chaperones]; Region: CydC; COG4987
430066002126	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
430066002127	Walker A/P-loop; other site
430066002128	ATP binding site [chemical binding]; other site
430066002129	Q-loop/lid; other site
430066002130	ABC transporter signature motif; other site
430066002131	Walker B; other site
430066002132	D-loop; other site
430066002133	H-loop/switch region; other site
430066002134	ABC-type transport system involved in cytochrome bd biosynthesis, ATPase and permease components [Energy production and conversion / Posttranslational modification, protein turnover, chaperones]; Region: CydD; COG4988
430066002135	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
430066002136	ATP-binding cassette domain of multidrug resistance protein-like transporters; Region: ABCC_MRP_Like; cd03228
430066002137	Walker A/P-loop; other site
430066002138	ATP binding site [chemical binding]; other site
430066002139	Q-loop/lid; other site
430066002140	ABC transporter signature motif; other site
430066002141	Walker B; other site
430066002142	D-loop; other site
430066002143	H-loop/switch region; other site
430066002144	Predicted transcriptional regulators [Transcription]; Region: COG1510
430066002145	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
430066002146	dimerization interface [polypeptide binding]; other site
430066002147	putative DNA binding site [nucleotide binding]; other site
430066002148	putative Zn2+ binding site [ion binding]; other site
430066002149	putative monovalent cation/H+ antiporter subunit G; Reviewed; Region: PRK12671
430066002150	putative monovalent cation/H+ antiporter subunit F; Reviewed; Region: PRK06161
430066002151	putative monovalent cation/H+ antiporter subunit E; Reviewed; Region: PRK12596
430066002152	putative monovalent cation/H+ antiporter subunit D; Reviewed; Region: PRK12666
430066002153	NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361
430066002154	putative monovalent cation/H+ antiporter subunit C; Reviewed; Region: PRK09094
430066002155	putative monovalent cation/H+ antiporter subunit A; Reviewed; Region: PRK12648
430066002156	NADH-Ubiquinone oxidoreductase (complex I), chain 5 N-terminus; Region: Oxidored_q1_N; pfam00662
430066002157	NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361
430066002158	Multisubunit Na+/H+ antiporter, MnhB subunit [Inorganic ion transport and metabolism]; Region: MnhB; COG2111
430066002159	monovalent cation:proton antiporter; Region: 2a6301s02; TIGR00943
430066002160	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4529
430066002161	FAD-NAD(P)-binding; Region: NAD_binding_9; pfam13454
430066002162	Nitroreductase-like family 4.  A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes, nitrofurans and...; Region: Nitroreductase_4; cd02140
430066002163	dimer interface [polypeptide binding]; other site
430066002164	FMN binding site [chemical binding]; other site
430066002165	MogA_MoaB family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF) an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea; Region: MogA_MoaB; cd00886
430066002166	MPT binding site; other site
430066002167	trimer interface [polypeptide binding]; other site
430066002168	biotin synthase; Region: bioB; TIGR00433
430066002169	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
430066002170	FeS/SAM binding site; other site
430066002171	Biotin and Thiamin Synthesis associated domain; Region: BATS; smart00876
430066002172	8-amino-7-oxononanoate synthase; Reviewed; Region: PRK05958
430066002173	Aminotransferase class I and II; Region: Aminotran_1_2; pfam00155
430066002174	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
430066002175	catalytic residue [active]
430066002176	dithiobiotin synthetase; Reviewed; Region: bioD; PRK00090
430066002177	AAA domain; Region: AAA_26; pfam13500
430066002178	adenosylmethionine--8-amino-7-oxononanoate transaminase; Provisional; Region: PRK05964
430066002179	Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610
430066002180	inhibitor-cofactor binding pocket; inhibition site
430066002181	pyridoxal 5'-phosphate binding site [chemical binding]; other site
430066002182	catalytic residue [active]
430066002183	3-oxoacyl-(acyl carrier protein) synthase II; Reviewed; Region: PRK05963
430066002184	Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830
430066002185	dimer interface [polypeptide binding]; other site
430066002186	active site
430066002187	CoA binding pocket [chemical binding]; other site
430066002188	Homoserine trans-succinylase [Amino acid transport and metabolism]; Region: MetA; COG1897
430066002189	Type 1 glutamine amidotransferase (GATase1)-like domain found in homoserine trans-succinylase (HTS); Region: GATase1_HTS; cd03131
430066002190	proposed active site lysine [active]
430066002191	conserved cys residue [active]
430066002192	Lyzozyme M1 (1,4-beta-N-acetylmuramidase) [Cell envelope biogenesis, outer membrane]; Region: Acm; COG3757
430066002193	Uncharacterized bacterial muramidase containing a glycosyl hydrolase family 25 (GH25) catalytic domain. Endo-N-acetylmuramidases are lysozymes (also referred to as peptidoglycan hydrolases) that degrade bacterial cell walls by catalyzing the hydrolysis...; Region: GH25_muramidase_1; cd06413
430066002194	active site
430066002195	Na+/alanine symporter [Amino acid transport and metabolism]; Region: AlsT; COG1115
430066002196	Sodium:alanine symporter family; Region: Na_Ala_symp; pfam01235
430066002197	N-terminal domain of Streptomyces griseus SgaA (suppression of growth disturbance caused by A-factor at a high concentration under high osmolality during early growth phase), and similar domains; Region: SgaA_N_like; cd07247
430066002198	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
430066002199	N-terminal domain of Streptomyces griseus SgaA (suppression of growth disturbance caused by A-factor at a high concentration under high osmolality during early growth phase), and similar domains; Region: SgaA_N_like; cd07247
430066002200	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
430066002201	helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347
430066002202	Winged helix DNA-binding domain; Region: HTH_27; pfam13463
430066002203	NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252
430066002204	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
430066002205	Uncharacterized conserved protein [Function unknown]; Region: COG3189
430066002206	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
430066002207	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
430066002208	active site
430066002209	phosphorylation site [posttranslational modification]
430066002210	intermolecular recognition site; other site
430066002211	dimerization interface [polypeptide binding]; other site
430066002212	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
430066002213	DNA binding site [nucleotide binding]
430066002214	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
430066002215	HAMP domain; Region: HAMP; pfam00672
430066002216	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
430066002217	dimer interface [polypeptide binding]; other site
430066002218	phosphorylation site [posttranslational modification]
430066002219	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
430066002220	ATP binding site [chemical binding]; other site
430066002221	Mg2+ binding site [ion binding]; other site
430066002222	G-X-G motif; other site
430066002223	efflux pump membrane protein (multidrug resistance protein A); Region: 8a0101; TIGR00998
430066002224	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
430066002225	HlyD family secretion protein; Region: HlyD_3; pfam13437
430066002226	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
430066002227	putative substrate translocation pore; other site
430066002228	drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711
430066002229	MarR family; Region: MarR_2; pfam12802
430066002230	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cl17432
430066002231	NMT1/THI5 like; Region: NMT1; pfam09084
430066002232	substrate binding pocket [chemical binding]; other site
430066002233	membrane-bound complex binding site; other site
430066002234	hinge residues; other site
430066002235	ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116
430066002236	ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293
430066002237	Walker A/P-loop; other site
430066002238	ATP binding site [chemical binding]; other site
430066002239	Q-loop/lid; other site
430066002240	ABC transporter signature motif; other site
430066002241	Walker B; other site
430066002242	D-loop; other site
430066002243	H-loop/switch region; other site
430066002244	ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600
430066002245	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
430066002246	dimer interface [polypeptide binding]; other site
430066002247	conserved gate region; other site
430066002248	putative PBP binding loops; other site
430066002249	ABC-ATPase subunit interface; other site
430066002250	Uncharacterized conserved protein, contains double-stranded beta-helix domain [Function unknown]; Region: COG1917
430066002251	YhgE/Pip N-terminal domain; Region: pip_yhgE_Nterm; TIGR03061
430066002252	ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842
430066002253	ABC-2 type transporter; Region: ABC2_membrane; pfam01061
430066002254	ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230
430066002255	Walker A/P-loop; other site
430066002256	ATP binding site [chemical binding]; other site
430066002257	ABC transporter; Region: ABC_tran; pfam00005
430066002258	Q-loop/lid; other site
430066002259	ABC transporter signature motif; other site
430066002260	Walker B; other site
430066002261	D-loop; other site
430066002262	putative efflux pump membrane fusion protein; Provisional; Region: PRK03598
430066002263	Peptidase family M23; Region: Peptidase_M23; pfam01551
430066002264	HlyD family secretion protein; Region: HlyD_3; pfam13437
430066002265	putative DNA-binding transcriptional regulator; Provisional; Region: PRK11552
430066002266	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
430066002267	Domain of unknown function (DUF1956); Region: DUF1956; pfam09209
430066002268	Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628
430066002269	Domain of unknown function DUF20; Region: UPF0118; pfam01594
430066002270	Transcriptional regulators [Transcription]; Region: GntR; COG1802
430066002271	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
430066002272	DNA-binding site [nucleotide binding]; DNA binding site
430066002273	FCD domain; Region: FCD; pfam07729
430066002274	Predicted transporter component [General function prediction only]; Region: COG2391
430066002275	Sulphur transport; Region: Sulf_transp; pfam04143
430066002276	Domain of unknown function (DUF4341); Region: DUF4341; pfam14241
430066002277	Predicted transporter component [General function prediction only]; Region: COG2391
430066002278	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
430066002279	dimerization interface [polypeptide binding]; other site
430066002280	putative DNA binding site [nucleotide binding]; other site
430066002281	putative Zn2+ binding site [ion binding]; other site
430066002282	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2354
430066002283	Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487
430066002284	active site
430066002285	catalytic residues [active]
430066002286	metal binding site [ion binding]; metal-binding site
430066002287	D-3-phosphoglycerate dehydrogenase; Provisional; Region: PRK11790
430066002288	Phosphoglycerate dehydrogenases, NAD-binding and catalytic domains; Region: PGDH_3; cd12176
430066002289	ligand binding site [chemical binding]; other site
430066002290	NAD binding site [chemical binding]; other site
430066002291	tetramer interface [polypeptide binding]; other site
430066002292	catalytic site [active]
430066002293	C-terminal ACT (regulatory) domain of D-3-Phosphoglycerate Dehydrogenase (3PGDH) found in fungi and bacteria; Region: ACT_3PGDH; cd04901
430066002294	L-serine binding site [chemical binding]; other site
430066002295	ACT domain interface; other site
430066002296	Arabinose-binding domain of AraC transcription regulator, N-term; Region: Arabinose_bd; pfam12625
430066002297	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
430066002298	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
430066002299	Acyl-coenzyme A synthetases/AMP-(fatty) acid ligases [Lipid metabolism]; Region: Acs; COG0365
430066002300	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
430066002301	active site
430066002302	CoA binding site [chemical binding]; other site
430066002303	AMP binding site [chemical binding]; other site
430066002304	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
430066002305	active site
430066002306	acetyl-CoA acetyltransferase; Provisional; Region: PRK06954
430066002307	Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751
430066002308	dimer interface [polypeptide binding]; other site
430066002309	active site
430066002310	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
430066002311	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
430066002312	active site
430066002313	methionine sulfoxide reductase B; Provisional; Region: PRK00222
430066002314	SelR domain; Region: SelR; pfam01641
430066002315	DNA-binding transcriptional regulator HcaR; Provisional; Region: PRK09906
430066002316	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
430066002317	The C-terminal substrate binding domain of LysR-type transcrptional regulator BudR, which is responsible for activation of the expression of the butanediol operon genes; contains the type 2 periplasmic binding fold; Region: PBP2_BudR; cd08451
430066002318	putative dimerization interface [polypeptide binding]; other site
430066002319	putative substrate binding pocket [chemical binding]; other site
430066002320	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
430066002321	Major Facilitator Superfamily; Region: MFS_1; pfam07690
430066002322	putative substrate translocation pore; other site
430066002323	Glycerol kinase [Energy production and conversion]; Region: GlpK; COG0554
430066002324	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037
430066002325	nucleotide binding site [chemical binding]; other site
430066002326	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037
430066002327	Glycerol kinase [Energy production and conversion]; Region: GlpK; COG0554
430066002328	nucleotide binding site [chemical binding]; other site
430066002329	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
430066002330	Periplasmic protein involved in polysaccharide export, contains    SLBB domain of b-grasp fold [Cell wall/membrane/envelope biogenesis]; Region: Wza; COG1596
430066002331	Polysaccharide biosynthesis/export protein; Region: Poly_export; pfam02563
430066002332	Uncharacterized protein involved in exopolysaccharide biosynthesis [Cell envelope biogenesis, outer membrane]; Region: GumC; COG3206
430066002333	Chain length determinant protein; Region: Wzz; cl15801
430066002334	AAA domain; Region: AAA_31; pfam13614
430066002335	Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170
430066002336	G3 box; other site
430066002337	Switch II region; other site
430066002338	G4 box; other site
430066002339	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
430066002340	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
430066002341	DNA binding residues [nucleotide binding]
430066002342	dimerization interface [polypeptide binding]; other site
430066002343	cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664
430066002344	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
430066002345	ligand binding site [chemical binding]; other site
430066002346	flexible hinge region; other site
430066002347	helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092
430066002348	putative switch regulator; other site
430066002349	non-specific DNA interactions [nucleotide binding]; other site
430066002350	DNA binding site [nucleotide binding]
430066002351	sequence specific DNA binding site [nucleotide binding]; other site
430066002352	putative cAMP binding site [chemical binding]; other site
430066002353	N-acetylneuraminic acid mutarotase; Provisional; Region: PRK14131
430066002354	Putative N-acetylmannosamine-6-phosphate epimerase [Carbohydrate transport and metabolism]; Region: NanE; COG3010
430066002355	N-acetylmannosamine-6-phosphate epimerase (NanE) converts N-acetylmannosamine-6-phosphate to N-acetylglucosamine-6-phosphate. This reaction is part of the pathway that allows the usage of sialic acid as a carbohydrate source. Sialic acids are a family of...; Region: NanE; cd04729
430066002356	putative active site cavity [active]
430066002357	N-acetylmannosamine kinase; Provisional; Region: PRK05082
430066002358	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012
430066002359	nucleotide binding site [chemical binding]; other site
430066002360	Transcriptional regulators [Transcription]; Region: FadR; COG2186
430066002361	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
430066002362	DNA-binding site [nucleotide binding]; DNA binding site
430066002363	FCD domain; Region: FCD; pfam07729
430066002364	ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747
430066002365	The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cd00995
430066002366	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601
430066002367	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
430066002368	dimer interface [polypeptide binding]; other site
430066002369	conserved gate region; other site
430066002370	putative PBP binding loops; other site
430066002371	ABC-ATPase subunit interface; other site
430066002372	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173
430066002373	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
430066002374	dimer interface [polypeptide binding]; other site
430066002375	conserved gate region; other site
430066002376	putative PBP binding loops; other site
430066002377	ABC-ATPase subunit interface; other site
430066002378	Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329
430066002379	Dihydrodipicolinate synthase family; Region: DHDPS-like; cd00408
430066002380	inhibitor site; inhibition site
430066002381	active site
430066002382	dimer interface [polypeptide binding]; other site
430066002383	catalytic residue [active]
430066002384	ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444
430066002385	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
430066002386	Walker A/P-loop; other site
430066002387	ATP binding site [chemical binding]; other site
430066002388	Q-loop/lid; other site
430066002389	ABC transporter signature motif; other site
430066002390	Walker B; other site
430066002391	D-loop; other site
430066002392	H-loop/switch region; other site
430066002393	oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727
430066002394	ABC-type oligopeptide transport system, ATPase component [Amino acid transport and metabolism]; Region: AppF; COG4608
430066002395	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
430066002396	Walker A/P-loop; other site
430066002397	ATP binding site [chemical binding]; other site
430066002398	Q-loop/lid; other site
430066002399	ABC transporter signature motif; other site
430066002400	Walker B; other site
430066002401	D-loop; other site
430066002402	H-loop/switch region; other site
430066002403	oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727
430066002404	Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408
430066002405	Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673
430066002406	Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673
430066002407	Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408
430066002408	Zn-dependent alcohol dehydrogenases, class III [Energy production and conversion]; Region: AdhC; COG1062
430066002409	Zinc-dependent alcohol dehydrogenases (ADH) and class III ADG (AKA formaldehyde dehydrogenase); Region: liver_ADH_like1; cd08281
430066002410	NAD binding site [chemical binding]; other site
430066002411	catalytic Zn binding site [ion binding]; other site
430066002412	substrate binding site [chemical binding]; other site
430066002413	structural Zn binding site [ion binding]; other site
430066002414	ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683
430066002415	Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011
430066002416	Aldehyde dehydrogenase family; Region: Aldedh; pfam00171
430066002417	Mitochondrial succinate-semialdehyde dehydrogenase and ALDH family members 5A1 and 5F1-like; Region: ALDH_F5_SSADH_GabD; cd07103
430066002418	tetramerization interface [polypeptide binding]; other site
430066002419	NAD(P) binding site [chemical binding]; other site
430066002420	catalytic residues [active]
430066002421	choline dehydrogenase; Validated; Region: PRK02106
430066002422	GMC oxidoreductase; Region: GMC_oxred_C; pfam05199
430066002423	Shikimate 5-dehydrogenase [Amino acid transport and metabolism]; Region: AroE; COG0169
430066002424	Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501
430066002425	NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065
430066002426	shikimate binding site; other site
430066002427	NAD(P) binding site [chemical binding]; other site
430066002428	3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653
430066002429	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
430066002430	NAD(P) binding site [chemical binding]; other site
430066002431	active site
430066002432	ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410
430066002433	ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224
430066002434	Walker A/P-loop; other site
430066002435	ATP binding site [chemical binding]; other site
430066002436	Q-loop/lid; other site
430066002437	ABC transporter signature motif; other site
430066002438	Walker B; other site
430066002439	D-loop; other site
430066002440	H-loop/switch region; other site
430066002441	ABC-type branched-chain amino acid transport system, permease component [Amino acid transport and metabolism]; Region: LivM; COG4177
430066002442	Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581
430066002443	TM-ABC transporter signature motif; other site
430066002444	ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411
430066002445	ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219
430066002446	Walker A/P-loop; other site
430066002447	ATP binding site [chemical binding]; other site
430066002448	Q-loop/lid; other site
430066002449	ABC transporter signature motif; other site
430066002450	Walker B; other site
430066002451	D-loop; other site
430066002452	H-loop/switch region; other site
430066002453	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
430066002454	Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582
430066002455	TM-ABC transporter signature motif; other site
430066002456	ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683
430066002457	Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011
430066002458	putative NAD(P)H quinone oxidoreductase, PIG3 family; Region: quinone_pig3; TIGR02824
430066002459	PIG3 p53-inducible quinone oxidoreductase; Region: p53_inducible_oxidoreductase; cd05276
430066002460	NAD(P) binding site [chemical binding]; other site
430066002461	Transcriptional regulators [Transcription]; Region: GntR; COG1802
430066002462	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
430066002463	DNA-binding site [nucleotide binding]; DNA binding site
430066002464	FCD domain; Region: FCD; pfam07729
430066002465	Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124
430066002466	Cytochrome P450; Region: p450; cl12078
430066002467	acetate kinase; Provisional; Region: PRK07058
430066002468	propionate/acetate kinase; Provisional; Region: PRK12379
430066002469	putative phosphoketolase; Provisional; Region: PRK05261
430066002470	Thiamine pyrophosphate (TPP) family, Phosphoketolase (PK) subfamily, TPP-binding module; PK catalyzes the conversion of D-xylulose 5-phosphate and phosphate to acetyl phosphate, D-glyceraldehyde-3-phosphate and H2O. This enzyme requires divalent...; Region: TPP_PK; cd02011
430066002471	TPP-binding site; other site
430066002472	XFP C-terminal domain; Region: XFP_C; pfam09363
430066002473	Polyferredoxin [Energy production and conversion]; Region: NapH; COG0348
430066002474	4Fe-4S binding domain; Region: Fer4_5; pfam12801
430066002475	High-affinity Fe2+/Pb2+ permease [Inorganic ion transport and metabolism]; Region: FTR1; COG0672
430066002476	Cupredoxin-like domain; Region: Cupredoxin_1; pfam13473
430066002477	Uncharacterized protein probably involved in high-affinity Fe2+ transport [Inorganic ion transport and metabolism]; Region: Tpd; COG3470
430066002478	GMP synthase; Reviewed; Region: guaA; PRK00074
430066002479	Type 1 glutamine amidotransferase (GATase1) domain found in GMP synthetase; Region: GATase1_GMP_Synthase; cd01742
430066002480	AMP/PPi binding site [chemical binding]; other site
430066002481	candidate oxyanion hole; other site
430066002482	catalytic triad [active]
430066002483	potential glutamine specificity residues [chemical binding]; other site
430066002484	The C-terminal domain of GMP synthetase. It contains two subdomains; the ATP pyrophosphatase domain which closes to the N-termial and the dimerization domain at C-terminal end. The ATP-PPase is a twisted, five-stranded parallel beta-sheet sandwiched...; Region: GMP_synthase_C; cd01997
430066002485	ATP Binding subdomain [chemical binding]; other site
430066002486	Ligand Binding sites [chemical binding]; other site
430066002487	Dimerization subdomain; other site
430066002488	5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase; Validated; Region: PRK06026
430066002489	5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase, putative; Region: MTA/SAH-nuc-hyp; TIGR01705
430066002490	PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria.  Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443
430066002491	CoenzymeA binding site [chemical binding]; other site
430066002492	subunit interaction site [polypeptide binding]; other site
430066002493	PHB binding site; other site
430066002494	tRNA and rRNA cytosine-C5-methylases [Translation, ribosomal structure and biogenesis]; Region: Sun; COG0144
430066002495	NOL1/NOP2/sun family putative RNA methylase; Region: nop2p; TIGR00446
430066002496	Disulfide bond formation protein DsbB [Posttranslational modification, protein turnover, chaperones]; Region: DsbB; COG1495
430066002497	Catalase [Inorganic ion transport and metabolism]; Region: KatE; COG0753
430066002498	Clade 3 of the heme-binding enzyme catalase; Region: catalase_clade_3; cd08156
430066002499	tetramer interface [polypeptide binding]; other site
430066002500	heme binding pocket [chemical binding]; other site
430066002501	NADPH binding site [chemical binding]; other site
430066002502	DNA-binding transcriptional regulator OxyR; Provisional; Region: PRK11151
430066002503	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
430066002504	The C-terminal substrate-binding domain of the LysR-type transcriptional regulator OxyR, a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_OxyR; cd08411
430066002505	dimerization interface [polypeptide binding]; other site
430066002506	Cytochrome c [Energy production and conversion]; Region: COG3258
430066002507	Cytochrome c; Region: Cytochrom_C; pfam00034
430066002508	inosine 5'-monophosphate dehydrogenase; Reviewed; Region: PRK05567
430066002509	TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186
430066002510	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in the inosine 5' monophosphate dehydrogenase (IMPDH) protein.  IMPDH is an essential enzyme that catalyzes the first step unique to GTP synthesis, playing a...; Region: CBS_pair_IMPDH; cd04601
430066002511	IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381
430066002512	active site
430066002513	Chloride channel protein EriC [Inorganic ion transport and metabolism]; Region: EriC; COG0038
430066002514	ClC chloride channel family. These protein sequences, closely related to the ClC Eric family, are putative halogen ion (Cl-, Br- and I-) transport proteins found in eubacteria. They belong to the ClC superfamily of chloride ion channels, which share a...; Region: EriC_like; cd01034
430066002515	putative ion selectivity filter; other site
430066002516	putative pore gating glutamate residue; other site
430066002517	putative H+/Cl- coupling transport residue; other site
430066002518	nylC-like family; composed of proteins with similarity to Flavobacterium endo-type 6-aminohexanoate-oligomer hydrolase (EIII), the product of the nylon oligomer degradation gene, nylC. EIII is an amide hydrolase that catalyzes the degradation of...; Region: nylC_like; cd02252
430066002519	putative active site pocket [active]
430066002520	cleavage site
430066002521	Phosphomannomutase [Carbohydrate transport and metabolism]; Region: {ManB}; COG1109
430066002522	ManB is a bacterial phosphomannomutase (PMM) that catalyzes the conversion of mannose 6-phosphate to mannose-1-phosphate in the second of three steps in the GDP-mannose pathway, in which GDP-D-mannose is synthesized from fructose-6-phosphate. In...; Region: ManB; cd03088
430066002523	active site
430066002524	substrate binding site [chemical binding]; other site
430066002525	metal binding site [ion binding]; metal-binding site
430066002526	mannose-1-phosphate guanylyltransferase/mannose-6-phosphate isomerase; Region: GMP_PMI; TIGR01479
430066002527	GDP-M1P_Guanylyltransferase catalyzes the formation of GDP-Mannose; Region: GDP-M1P_Guanylyltransferase; cd02509
430066002528	Substrate binding site; other site
430066002529	Mannose-6-phosphate isomerase; Region: MannoseP_isomer; pfam01050
430066002530	DNA-binding transcriptional activator GcvA; Provisional; Region: PRK11139
430066002531	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
430066002532	LysR substrate binding domain; Region: LysR_substrate; pfam03466
430066002533	Predicted signal transduction protein containing sensor and EAL domains [Signal transduction mechanisms]; Region: COG4943
430066002534	CSS motif domain associated with EAL; Region: CSS-motif; pfam12792
430066002535	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
430066002536	acid-resistance protein; Provisional; Region: PRK10208
430066002537	glutaminase; Reviewed; Region: PRK12356
430066002538	Glutaminase [Amino acid transport and metabolism]; Region: GlsA; COG2066
430066002539	putative glutamate/gamma-aminobutyrate antiporter; Region: put_Glu_GABA_T; TIGR03813
430066002540	Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321
430066002541	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
430066002542	catalytic residue [active]
430066002543	Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321
430066002544	Predicted membrane protein [Function unknown]; Region: COG4803
430066002545	RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730
430066002546	HlyD family secretion protein; Region: HlyD_3; pfam13437
430066002547	Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841
430066002548	Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841
430066002549	IclR helix-turn-helix domain; Region: HTH_IclR; cl17605
430066002550	ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177
430066002551	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
430066002552	dimer interface [polypeptide binding]; other site
430066002553	conserved gate region; other site
430066002554	putative PBP binding loops; other site
430066002555	ABC-ATPase subunit interface; other site
430066002556	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
430066002557	dimer interface [polypeptide binding]; other site
430066002558	conserved gate region; other site
430066002559	putative PBP binding loops; other site
430066002560	ABC-ATPase subunit interface; other site
430066002561	ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842
430066002562	ATP-binding cassette domain of the polyamine transporter; Region: ABC_PotA_N; cd03300
430066002563	Walker A/P-loop; other site
430066002564	ATP binding site [chemical binding]; other site
430066002565	Q-loop/lid; other site
430066002566	ABC transporter signature motif; other site
430066002567	Walker B; other site
430066002568	D-loop; other site
430066002569	H-loop/switch region; other site
430066002570	TOBE domain; Region: TOBE_2; pfam08402
430066002571	Spermidine/putrescine-binding periplasmic protein [Amino acid transport and metabolism]; Region: PotD; COG0687
430066002572	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199
430066002573	Domain of unknown function (DUF3597); Region: DUF3597; pfam12200
430066002574	cell division topological specificity factor MinE; Reviewed; Region: minE; PRK00296
430066002575	Septum formation inhibitor-activating ATPase [Cell division and chromosome partitioning]; Region: MinD; COG2894
430066002576	Bacterial cell division requires the formation of a septum at mid-cell. The site is determined by the min operon products MinC, MinD and MinE. MinC is a nonspecific inhibitor of the septum protein FtsZ. MinE is the supressor of MinC. MinD plays a pivotal...; Region: MinD; cd02036
430066002577	Switch I; other site
430066002578	Switch II; other site
430066002579	septum formation inhibitor; Reviewed; Region: minC; PRK05177
430066002580	Septum formation inhibitor MinC, C-terminal domain; Region: MinC_C; pfam03775
430066002581	ribonucleotide-diphosphate reductase subunit beta; Provisional; Region: nrdF2; PRK13966
430066002582	Ribonucleotide Reductase, R2/beta subunit, ferritin-like diiron-binding domain; Region: RNRR2; cd01049
430066002583	dimer interface [polypeptide binding]; other site
430066002584	putative radical transfer pathway; other site
430066002585	diiron center [ion binding]; other site
430066002586	tyrosyl radical; other site
430066002587	ribonucleotide-diphosphate reductase subunit alpha; Validated; Region: PRK08188
430066002588	Ribonucleotide reductase N-terminal; Region: RNR_N; pfam08343
430066002589	Class I ribonucleotide reductase; Region: RNR_I; cd01679
430066002590	active site
430066002591	dimer interface [polypeptide binding]; other site
430066002592	catalytic residues [active]
430066002593	effector binding site; other site
430066002594	R2 peptide binding site; other site
430066002595	ribonucleotide reductase stimulatory protein; Reviewed; Region: nrdI; PRK03600
430066002596	NrdH-redoxin (NrdH) family; NrdH is a small monomeric protein with a conserved redox active CXXC motif within a TRX fold, characterized by a glutaredoxin (GRX)-like sequence and TRX-like activity profile. In vitro, it displays protein disulfide reductase...; Region: NrdH; cd02976
430066002597	catalytic residues [active]
430066002598	Transmembrane secretion effector; Region: MFS_3; pfam05977
430066002599	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
430066002600	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
430066002601	Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673
430066002602	Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408
430066002603	Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894
430066002604	Trehalose utilization protein [Carbohydrate transport and metabolism]; Region: ThuA; COG4813
430066002605	conserved cys residue [active]
430066002606	ABC-type sugar transport systems, ATPase components [Carbohydrate transport and metabolism]; Region: MalK; COG3839
430066002607	The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301
430066002608	Walker A/P-loop; other site
430066002609	ATP binding site [chemical binding]; other site
430066002610	Q-loop/lid; other site
430066002611	ABC transporter signature motif; other site
430066002612	Walker B; other site
430066002613	D-loop; other site
430066002614	H-loop/switch region; other site
430066002615	TOBE domain; Region: TOBE_2; pfam08402
430066002616	ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177
430066002617	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
430066002618	dimer interface [polypeptide binding]; other site
430066002619	conserved gate region; other site
430066002620	putative PBP binding loops; other site
430066002621	ABC-ATPase subunit interface; other site
430066002622	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427
430066002623	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653
430066002624	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547
430066002625	Transcriptional regulators [Transcription]; Region: PurR; COG1609
430066002626	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
430066002627	DNA binding site [nucleotide binding]
430066002628	domain linker motif; other site
430066002629	Ligand-binding domain of DNA transcription repressors specific for raffinose (RafR) and alpha-glucosides (AglR) which are members of the LacI-GalR family of bacterial transcription regulators; Region: PBP1_AglR_RafR_like; cd06271
430066002630	ligand binding site [chemical binding]; other site
430066002631	transcriptional activator FtrB; Provisional; Region: ftrB; PRK09392
430066002632	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
430066002633	ligand binding site [chemical binding]; other site
430066002634	flexible hinge region; other site
430066002635	helix_turn_helix, cAMP Regulatory protein; Region: HTH_CRP; smart00419
430066002636	Nitrate/nitrite transporter [Inorganic ion transport and metabolism]; Region: NarK; COG2223
430066002637	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
430066002638	putative substrate translocation pore; other site
430066002639	nitrate/nitrite transport protein NarU; Provisional; Region: PRK15034
430066002640	Nitrate reductase alpha subunit [Energy production and conversion]; Region: NarG; COG5013
430066002641	Respiratory nitrate reductase A (NarGHI), alpha chain (NarG) and related proteins. Under anaerobic conditions in the presence of nitrate, E. coli synthesizes the cytoplasmic membrane-bound quinol-nitrate oxidoreductase (NarGHI), which reduces nitrate to...; Region: MopB_Nitrate-R-NarG-like; cd02750
430066002642	[4Fe-4S] binding site [ion binding]; other site
430066002643	Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a  large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928
430066002644	Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a  large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928
430066002645	Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a  large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928
430066002646	Respiratory nitrate reductase A (NarGHI), alpha chain (NarG) and related proteins. Under anaerobic conditions in the presence of nitrate, E. coli synthesizes the cytoplasmic membrane-bound quinol-nitrate oxidoreductase (NarGHI), which reduces nitrate to...; Region: MopB_CT_Nitrate-R-NarG-like; cd02776
430066002647	molybdopterin cofactor binding site; other site
430066002648	Nitrate reductase beta subunit [Energy production and conversion]; Region: NarY; COG1140
430066002649	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cl00470
430066002650	Nitrate reductase delta subunit [Energy production and conversion]; Region: NarJ; COG2180
430066002651	Nitrate reductase gamma subunit; Region: Nitrate_red_gam; pfam02665
430066002652	Parvulin-like peptidyl-prolyl isomerase [Posttranslational modification, protein turnover, chaperones]; Region: SurA; COG0760
430066002653	PPIC-type PPIASE domain; Region: Rotamase; pfam00639
430066002654	Protein of unknown function (DUF2478); Region: DUF2478; pfam10649
430066002655	3-octaprenyl-4-hydroxybenzoate carboxy-lyase; Provisional; Region: PRK06029
430066002656	Flavoprotein; Region: Flavoprotein; pfam02441
430066002657	Putative lipid carrier protein [Lipid metabolism]; Region: COG3154
430066002658	Collagenase and related proteases [Posttranslational modification, protein turnover, chaperones]; Region: COG0826
430066002659	Peptidase family U32; Region: Peptidase_U32; pfam01136
430066002660	Collagenase and related proteases [Posttranslational modification, protein turnover, chaperones]; Region: COG0826
430066002661	putative protease; Provisional; Region: PRK15447
430066002662	ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116
430066002663	ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293
430066002664	Walker A/P-loop; other site
430066002665	ATP binding site [chemical binding]; other site
430066002666	Q-loop/lid; other site
430066002667	ABC transporter signature motif; other site
430066002668	Walker B; other site
430066002669	D-loop; other site
430066002670	H-loop/switch region; other site
430066002671	ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600
430066002672	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
430066002673	dimer interface [polypeptide binding]; other site
430066002674	conserved gate region; other site
430066002675	putative PBP binding loops; other site
430066002676	ABC-ATPase subunit interface; other site
430066002677	ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components [Inorganic ion transport and metabolism]; Region: TauA; COG0715
430066002678	NMT1-like family; Region: NMT1_2; pfam13379
430066002679	Uncharacterized protein involved in response to NO [Inorganic ion transport and metabolism]; Region: NnrS; COG3213
430066002680	Plastocyanin [Energy production and conversion]; Region: PetE; COG3794
430066002681	pseudoazurin; Region: pseudoazurin; TIGR02375
430066002682	cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664
430066002683	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
430066002684	ligand binding site [chemical binding]; other site
430066002685	flexible hinge region; other site
430066002686	helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092
430066002687	putative switch regulator; other site
430066002688	non-specific DNA interactions [nucleotide binding]; other site
430066002689	DNA binding site [nucleotide binding]
430066002690	sequence specific DNA binding site [nucleotide binding]; other site
430066002691	putative cAMP binding site [chemical binding]; other site
430066002692	Membrane-associated lipoprotein involved in thiamine biosynthesis [Coenzyme metabolism]; Region: ApbE; COG1477
430066002693	ApbE family; Region: ApbE; pfam02424
430066002694	Predicted lipoprotein involved in nitrous oxide reduction [Energy production and conversion]; Region: NosL; COG4314
430066002695	ABC-2 family transporter protein; Region: ABC2_membrane_2; pfam12679
430066002696	ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131
430066002697	ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230
430066002698	Walker A/P-loop; other site
430066002699	ATP binding site [chemical binding]; other site
430066002700	Q-loop/lid; other site
430066002701	ABC transporter signature motif; other site
430066002702	Walker B; other site
430066002703	D-loop; other site
430066002704	H-loop/switch region; other site
430066002705	Nitrous oxidase accessory protein [Inorganic ion transport and metabolism]; Region: NosD; COG3420
430066002706	parallel beta-helix repeat (two copies); Region: para_beta_helix; TIGR03804
430066002707	parallel beta-helix repeat (two copies); Region: para_beta_helix; TIGR03804
430066002708	nitrous-oxide reductase; Validated; Region: PRK02888
430066002709	Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; pfam00116
430066002710	Regulator of nitric oxide reductase transcription [Transcription]; Region: NosR; COG3901
430066002711	ferredoxin-type protein, NapH/MauN family; Region: napH_; TIGR02163
430066002712	4Fe-4S binding domain; Region: Fer4_5; pfam12801
430066002713	4Fe-4S binding domain; Region: Fer4_5; pfam12801
430066002714	ABC-type uncharacterized transport system, permease and ATPase components [General function prediction only]; Region: COG4178
430066002715	ABC transporter transmembrane region 2; Region: ABC_membrane_2; cl00549
430066002716	ATP-binding cassette domain of peroxisomal transporter, subfamily D; Region: ABCD_peroxisomal_ALDP; cd03223
430066002717	Protein of unknown function (DUF2384); Region: DUF2384; pfam09722
430066002718	RES domain; Region: RES; smart00953
430066002719	Ribulose kinase [Energy production and conversion]; Region: AraB; COG1069
430066002720	Yersinia Pseudotuberculosis carbohydrate kinase-like subgroup; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_YpCarbK_like; cd07782
430066002721	N- and C-terminal domain interface [polypeptide binding]; other site
430066002722	active site
430066002723	MgATP binding site [chemical binding]; other site
430066002724	catalytic site [active]
430066002725	metal binding site [ion binding]; metal-binding site
430066002726	carbohydrate binding site [chemical binding]; other site
430066002727	putative homodimer interface [polypeptide binding]; other site
430066002728	Short-chain alcohol dehydrogenase of unknown specificity [General function prediction only]; Region: COG4221
430066002729	classical (c) SDRs; Region: SDR_c; cd05233
430066002730	NAD(P) binding site [chemical binding]; other site
430066002731	active site
430066002732	Transmembrane subunit (TM) of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which are involved in the uptake of branched-chain amino acids (AAs), as well as TMs of transporters involved in the uptake of...; Region: TM_PBP1_branched-chain-AA_like; cl00454
430066002733	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
430066002734	Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579
430066002735	TM-ABC transporter signature motif; other site
430066002736	ABC-type xylose transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: XylF; COG4213
430066002737	Periplasmic xylose-binding component of the ABC-type transport systems that belong to a family of pentose/hexose sugar-binding proteins of the type I periplasmic binding protein (PBP1) superfamily; Region: PBP1_ABC_xylose_binding; cd01538
430066002738	putative ligand binding site [chemical binding]; other site
430066002739	Transcriptional regulators [Transcription]; Region: PurR; COG1609
430066002740	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
430066002741	DNA binding site [nucleotide binding]
430066002742	domain linker motif; other site
430066002743	Ligand binding domain of DNA transcription repressor specific for fructose (FruR) and its close homologs; Region: PBP1_FruR; cd06274
430066002744	dimerization interface [polypeptide binding]; other site
430066002745	ligand binding site [chemical binding]; other site
430066002746	cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664
430066002747	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
430066002748	ligand binding site [chemical binding]; other site
430066002749	flexible hinge region; other site
430066002750	helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092
430066002751	putative switch regulator; other site
430066002752	non-specific DNA interactions [nucleotide binding]; other site
430066002753	DNA binding site [nucleotide binding]
430066002754	sequence specific DNA binding site [nucleotide binding]; other site
430066002755	putative cAMP binding site [chemical binding]; other site
430066002756	Uncharacterized conserved protein [Function unknown]; Region: COG1262
430066002757	Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; pfam03781
430066002758	nitrite reductase, copper-containing; Region: Cu_nitrite_red; TIGR02376
430066002759	Multicopper oxidase; Region: Cu-oxidase_3; pfam07732
430066002760	Multicopper oxidase; Region: Cu-oxidase; pfam00394
430066002761	Thioesterase domains of type I polyketide synthases or non-ribosomal peptide synthetases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3319
430066002762	Putative protein-S-isoprenylcysteine methyltransferase [Posttranslational modification, protein turnover, chaperones]; Region: STE14; COG2020
430066002763	Predicted metal-sulfur cluster biosynthetic enzyme [General function prediction only]; Region: PaaD; COG2151
430066002764	Uncharacterized conserved protein (DUF2249); Region: DUF2249; pfam10006
430066002765	SirA, YedF, and YeeD. Two-layered alpha/beta sandwich domain.  SirA (also known as UvrY,  and YhhP) belongs to a family of bacterial two-component response regulators that controls secondary metabolism and virulence. The other member of this...; Region: SirA_YedF_YeeD; cd00291
430066002766	CPxP  motif; other site
430066002767	Uncharacterized conserved protein [Function unknown]; Region: COG4309
430066002768	Nitric oxide reductase activation protein [Inorganic ion transport and metabolism]; Region: NorD; COG4548
430066002769	norD type: Denitrifying bacteria contain both membrane bound and periplasmic nitrate reductases. Denitrification plays a major role  in completing the nitrogen cycle by converting nitrate or nitrite to nitrogen gas. The pathway for microbial...; Region: vWA_norD_type; cd01454
430066002770	metal ion-dependent adhesion site (MIDAS); other site
430066002771	MoxR-like ATPases [General function prediction only]; Region: COG0714
430066002772	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
430066002773	Walker A motif; other site
430066002774	ATP binding site [chemical binding]; other site
430066002775	Walker B motif; other site
430066002776	CbbQ/NirQ/NorQ C-terminal; Region: CbbQ_C; pfam08406
430066002777	Cytochrome C and Quinol oxidase polypeptide I; Region: COX1; pfam00115
430066002778	Heme-copper oxidase subunit I.  Heme-copper oxidases are transmembrane protein complexes in the respiratory chains of prokaryotes and mitochondria which catalyze the reduction of O2 and simultaneously pump protons across the membrane.  The superfamily is...; Region: Heme_Cu_Oxidase_I; cl00275
430066002779	Binuclear center (active site) [active]
430066002780	K-pathway; other site
430066002781	Putative proton exit pathway; other site
430066002782	Cytochrome c; Region: Cytochrom_C; pfam00034
430066002783	NorE_like subfamily of heme-copper oxidase subunit III.  Heme-copper oxidases include cytochrome c and ubiquinol oxidases.  Alcaligenes faecalis norE is found in a gene cluster containing norCB. norCB encodes the cytochrome c and cytochrome b subunits of...; Region: NorE_like; cd02862
430066002784	Hemerythrin HHE cation binding domain; Region: Hemerythrin; pfam01814
430066002785	Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244
430066002786	Polysaccharide biosynthesis protein; Region: Polysacc_synt_3; pfam13440
430066002787	Malate/L-lactate dehydrogenases [Energy production and conversion]; Region: COG2055
430066002788	Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329
430066002789	Dihydrodipicolinate synthase family; Region: DHDPS-like; cd00408
430066002790	inhibitor site; inhibition site
430066002791	active site
430066002792	dimer interface [polypeptide binding]; other site
430066002793	catalytic residue [active]
430066002794	Transcriptional regulators [Transcription]; Region: GntR; COG1802
430066002795	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
430066002796	DNA-binding site [nucleotide binding]; DNA binding site
430066002797	FCD domain; Region: FCD; pfam07729
430066002798	Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697
430066002799	EamA-like transporter family; Region: EamA; pfam00892
430066002800	EamA-like transporter family; Region: EamA; cl17759
430066002801	Predicted dehydrogenase [General function prediction only]; Region: COG0579
430066002802	hydroxyglutarate oxidase; Provisional; Region: PRK11728
430066002803	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
430066002804	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
430066002805	metal binding site [ion binding]; metal-binding site
430066002806	active site
430066002807	I-site; other site
430066002808	DnaQ-like (or DEDD) 3'-5' exonuclease domain superfamily; Region: DnaQ_like_exo; cl10012
430066002809	DNA polymerase III subunit epsilon; Validated; Region: PRK09182
430066002810	DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127
430066002811	active site
430066002812	catalytic site [active]
430066002813	substrate binding site [chemical binding]; other site
430066002814	ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124
430066002815	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
430066002816	Walker A/P-loop; other site
430066002817	ATP binding site [chemical binding]; other site
430066002818	Q-loop/lid; other site
430066002819	ABC transporter signature motif; other site
430066002820	Walker B; other site
430066002821	D-loop; other site
430066002822	H-loop/switch region; other site
430066002823	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; pfam08352
430066002824	ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444
430066002825	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
430066002826	Walker A/P-loop; other site
430066002827	ATP binding site [chemical binding]; other site
430066002828	Q-loop/lid; other site
430066002829	ABC transporter signature motif; other site
430066002830	Walker B; other site
430066002831	D-loop; other site
430066002832	H-loop/switch region; other site
430066002833	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097
430066002834	nickel ABC transporter, permease subunit NikC; Region: nickel_nikC; TIGR02790
430066002835	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
430066002836	dimer interface [polypeptide binding]; other site
430066002837	conserved gate region; other site
430066002838	putative PBP binding loops; other site
430066002839	ABC-ATPase subunit interface; other site
430066002840	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601
430066002841	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
430066002842	dimer interface [polypeptide binding]; other site
430066002843	conserved gate region; other site
430066002844	putative PBP binding loops; other site
430066002845	ABC-ATPase subunit interface; other site
430066002846	ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747
430066002847	The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_6; cd08494
430066002848	putative beta-ketoacyl acyl carrier protein [ACP] reductase (BKR), subgroup 3, classical (c) SDR; Region: BKR_3_SDR_c; cd05345
430066002849	3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK07231
430066002850	putative NAD(P) binding site [chemical binding]; other site
430066002851	active site
430066002852	Aldehyde dehydrogenase family; Region: Aldedh; pfam00171
430066002853	Uncharacterized Saccharopolyspora spinosa aldehyde dehydrogenase (AAS00426)-like; Region: ALDH_AAS00426; cd07109
430066002854	NAD(P) binding site [chemical binding]; other site
430066002855	catalytic residues [active]
430066002856	catalytic residues [active]
430066002857	Transcriptional regulators [Transcription]; Region: GntR; COG1802
430066002858	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
430066002859	DNA-binding site [nucleotide binding]; DNA binding site
430066002860	FCD domain; Region: FCD; pfam07729
430066002861	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
430066002862	Major Facilitator Superfamily; Region: MFS_1; pfam07690
430066002863	putative substrate translocation pore; other site
430066002864	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
430066002865	Domain of unknown function (DUF4105); Region: DUF4105; pfam13387
430066002866	ribonuclease P; Reviewed; Region: rnpA; PRK01313
430066002867	membrane protein insertase; Provisional; Region: PRK01318
430066002868	membrane protein insertase, YidC/Oxa1 family, C-terminal domain; Region: yidC_oxa1_cterm; TIGR03592
430066002869	YihA (EngB) GTPase family; Region: YihA_EngB; cd01876
430066002870	G1 box; other site
430066002871	GTP/Mg2+ binding site [chemical binding]; other site
430066002872	Switch I region; other site
430066002873	G2 box; other site
430066002874	G3 box; other site
430066002875	Switch II region; other site
430066002876	G4 box; other site
430066002877	G5 box; other site
430066002878	AAK_NAGK-C: N-Acetyl-L-glutamate kinase - cyclic (NAGK-C) catalyzes the phosphorylation of the gamma-COOH group of N-acetyl-L-glutamate (NAG) by ATP in the second step of arginine biosynthesis found in some bacteria and photosynthetic organisms using the...; Region: AAK_NAGK-C; cd04250
430066002879	homohexameric interface [polypeptide binding]; other site
430066002880	feedback inhibition sensing region; other site
430066002881	nucleotide binding site [chemical binding]; other site
430066002882	N-acetyl-L-glutamate binding site [chemical binding]; other site
430066002883	pyrimidine 5'-nucleotidase; Region: Pyr-5-nucltdase; TIGR01993
430066002884	?-D-glucose-1-phosphatase; Provisional; Region: PRK09456
430066002885	Predicted Rossmann fold nucleotide-binding protein [General function prediction only]; Region: COG1611
430066002886	2,3,4,5-tetrahydropyridine-2,6-carboxylate N-succinyltransferase; Provisional; Region: dapD; PRK11830
430066002887	2,3,4,5-tetrahydropyridine-2,6-dicarboxylate (THDP) N-succinyltransferase (also called THP succinyltransferase): THDP N-succinyltransferase catalyzes the conversion of tetrahydrodipicolinate and succinyl-CoA to N-succinyltetrahydrodipicolinate and CoA; Region: LbH_THP_succinylT; cd03350
430066002888	trimer interface [polypeptide binding]; other site
430066002889	active site
430066002890	substrate binding site [chemical binding]; other site
430066002891	CoA binding site [chemical binding]; other site
430066002892	Bacterial transglutaminase-like cysteine proteinase BTLCP; Region: BTLCP; cl17596
430066002893	succinyl-diaminopimelate desuccinylase; Reviewed; Region: PRK13009
430066002894	M20 Peptidase proteobacterial DapE encoded N-succinyl-L,L-diaminopimelic acid desuccinylase; Region: M20_DapE_proteobac; cd03891
430066002895	metal binding site [ion binding]; metal-binding site
430066002896	dimer interface [polypeptide binding]; other site
430066002897	Eukaryotic and bacterial pseudouridine synthases similar to E.  coli TruA; Region: PseudoU_synth_EcTruA; cd02570
430066002898	tRNA pseudouridine synthase A; Validated; Region: truA; PRK00021
430066002899	active site
430066002900	dimerization interface 3.5A [polypeptide binding]; other site
430066002901	methionyl-tRNA formyltransferase; Reviewed; Region: fmt; PRK00005
430066002902	Methionyl-tRNA formyltransferase, N-terminal hydrolase domain; Region: FMT_core_Met-tRNA-FMT_N; cd08646
430066002903	putative active site [active]
430066002904	substrate binding site [chemical binding]; other site
430066002905	putative cosubstrate binding site; other site
430066002906	catalytic site [active]
430066002907	C-terminal domain of Formyltransferase and other enzymes; Region: Met_tRNA_FMT_C; cd08704
430066002908	substrate binding site [chemical binding]; other site
430066002909	Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487
430066002910	active site
430066002911	catalytic residues [active]
430066002912	metal binding site [ion binding]; metal-binding site
430066002913	Predicted nuclease of restriction endonuclease-like fold, RmuC family [General function prediction only]; Region: COG1322
430066002914	RmuC family; Region: RmuC; pfam02646
430066002915	Uncharacterized protein conserved in bacteria [Posttranslational modification, protein turnover, chaperones]; Region: COG3526
430066002916	The GIY-YIG domain of uncharacterized protein family UPF0213 related to structure-specific endonuclease SLX1; Region: GIY-YIG_UPF0213; cd10456
430066002917	GIY-YIG motif/motif A; other site
430066002918	putative active site [active]
430066002919	putative metal binding site [ion binding]; other site
430066002920	GTP-binding protein LepA; Provisional; Region: PRK05433
430066002921	LepA also known as Elongation Factor 4 (EF4); Region: LepA; cd01890
430066002922	G1 box; other site
430066002923	putative GEF interaction site [polypeptide binding]; other site
430066002924	GTP/Mg2+ binding site [chemical binding]; other site
430066002925	Switch I region; other site
430066002926	G2 box; other site
430066002927	G3 box; other site
430066002928	Switch II region; other site
430066002929	G4 box; other site
430066002930	G5 box; other site
430066002931	lepA_II: This subfamily represents the domain II of LepA, a GTP-binding protein localized in the cytoplasmic membrane. The N-terminal domain of LepA shares regions of homology to translation factors. In terms of interaction with the ribosome, EF-G, EF-Tu...; Region: lepA_II; cd03699
430066002932	lepA_C: This family represents the C-terminal region of LepA, a GTP-binding protein localized in the cytoplasmic membrane.   LepA is ubiquitous in Bacteria and Eukaryota (e.g. Saccharomyces cerevisiae GUF1p), but is missing from Archaea. LepA exhibits...; Region: lepA_C; cd03709
430066002933	GTP-binding protein LepA C-terminus; Region: LepA_C; pfam06421
430066002934	Predicted nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG0702
430066002935	NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, subunit 9, 39 kDa, (NDUFA9) -like, atypical (a) SDRs; Region: NDUFA9_like_SDR_a; cd05271
430066002936	putative NAD(P) binding site [chemical binding]; other site
430066002937	active site
430066002938	Undecaprenyl pyrophosphate phosphatase [Lipid transport and metabolism]; Region: BacA; COG1968
430066002939	Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625
430066002940	Glutathione S-transferase (GST) family, N-terminal domain; a large, diverse group of cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of  glutathione (GSH) with a wide range of endogenous and xenobiotic...; Region: GST_N_family; cd00570
430066002941	C-terminal domain interface [polypeptide binding]; other site
430066002942	GSH binding site (G-site) [chemical binding]; other site
430066002943	dimer interface [polypeptide binding]; other site
430066002944	C-terminal, alpha helical domain of the Glutathione S-transferase family; Region: GST_C_family; cd00299
430066002945	N-terminal domain interface [polypeptide binding]; other site
430066002946	dimer interface [polypeptide binding]; other site
430066002947	substrate binding pocket (H-site) [chemical binding]; other site
430066002948	epoxyqueuosine reductase; Region: TIGR00276
430066002949	Domain of unknown function (DUF1730); Region: DUF1730; pfam08331
430066002950	HEAT repeat; Region: HEAT; pfam02985
430066002951	Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451
430066002952	atypical (a) SDRs, subgroup 4; Region: SDR_a4; cd05266
430066002953	putative NAD(P) binding site [chemical binding]; other site
430066002954	penicillin-insensitive murein endopeptidase; Reviewed; Region: mepA; PRK09429
430066002955	Murein endopeptidase [Cell envelope biogenesis, outer membrane]; Region: MepA; COG3770
430066002956	Methylglyoxal synthase catalyzes the enolization of dihydroxyacetone phosphate (DHAP) to produce methylglyoxal. The first part of the catalytic mechanism is believed to be similar to TIM (triosephosphate isomerase) in that both enzymes utilize DHAP to...; Region: MGS; cd01422
430066002957	active site
430066002958	dimer interfaces [polypeptide binding]; other site
430066002959	catalytic residues [active]
430066002960	Glucokinase [Carbohydrate transport and metabolism]; Region: Glk; COG0837
430066002961	glucokinase, proteobacterial type; Region: glk; TIGR00749
430066002962	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
430066002963	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
430066002964	ATP-binding cassette domain of the bacterial lipid flippase and related proteins, subfamily C; Region: ABCC_MsbA; cd03251
430066002965	Walker A/P-loop; other site
430066002966	ATP binding site [chemical binding]; other site
430066002967	Q-loop/lid; other site
430066002968	ABC transporter signature motif; other site
430066002969	Walker B; other site
430066002970	D-loop; other site
430066002971	H-loop/switch region; other site
430066002972	Dihydrodipicolinate reductase [Amino acid transport and metabolism]; Region: DapB; COG0289
430066002973	Dihydrodipicolinate reductase, N-terminus; Region: DapB_N; pfam01113
430066002974	Dihydrodipicolinate reductase, C-terminus; Region: DapB_C; pfam05173
430066002975	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
430066002976	catalytic core [active]
430066002977	Predicted metal-dependent hydrolase with the TIM-barrel fold [General function prediction only]; Region: COG1574
430066002978	YtcJ_like metal dependent amidohydrolases. YtcJ is a Bacillus subtilis ORF of unknown function. The Arabidopsis homolog LAF3 has been identified as a factor required for photochrome A signalling; Region: YtcJ_like; cd01300
430066002979	active site
430066002980	Subfamily of the nitroreductase family that includes BluB protein in Rhodobacter capsulatus is involved in the conversion of cobinamide to cobalamin in Cobalamin (vitamin B12) biosynthesis. Nitroreductases typically reduce their substrates by using NAD(P)...; Region: BluB; cd02145
430066002981	putative FMN binding site [chemical binding]; other site
430066002982	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
430066002983	Ligand Binding Site [chemical binding]; other site
430066002984	Predicted membrane protein [Function unknown]; Region: COG3714
430066002985	aldehyde dehydrogenase family protein; Provisional; Region: PTZ00381
430066002986	Coniferyl aldehyde dehydrogenase-like; Region: ALDH_CALDH_CalB; cd07133
430066002987	NAD(P) binding site [chemical binding]; other site
430066002988	catalytic residues [active]
430066002989	Metal-dependent hydrolase [General function prediction only]; Region: ElsH; COG3568
430066002990	putative catalytic site [active]
430066002991	putative metal binding site [ion binding]; other site
430066002992	putative phosphate binding site [ion binding]; other site
430066002993	Phosphatidylserine/phosphatidylglycerophosphate/car diolipin synthases and related enzymes [Lipid metabolism]; Region: Cls; COG1502
430066002994	Putative catalytic domain, repeat 1, of uncharacterized proteins similar to bacterial cardiolipin synthase; Region: PLDc_CLS_unchar2_1; cd09157
430066002995	putative active site [active]
430066002996	catalytic site [active]
430066002997	Putative catalytic domain, repeat 2, of uncharacterized proteins similar to bacterial cardiolipin synthase; Region: PLDc_CLS_unchar2_2; cd09163
430066002998	putative active site [active]
430066002999	catalytic site [active]
430066003000	Peptide chain release factor RF-3 [Translation, ribosomal structure and biogenesis]; Region: PrfC; COG4108
430066003001	Release Factor 3 (RF3) protein involved in the terminal step of translocation in bacteria; Region: RF3; cd04169
430066003002	G1 box; other site
430066003003	putative GEF interaction site [polypeptide binding]; other site
430066003004	GTP/Mg2+ binding site [chemical binding]; other site
430066003005	Switch I region; other site
430066003006	G2 box; other site
430066003007	G3 box; other site
430066003008	Switch II region; other site
430066003009	G4 box; other site
430066003010	G5 box; other site
430066003011	RF3_II: this subfamily represents the domain II of bacterial Release Factor 3 (RF3). Termination of protein synthesis by the ribosome requires two release factor (RF) classes. The class II RF3 is a GTPase that removes class I RFs (RF1 or RF2) from the...; Region: RF3_II; cd03689
430066003012	bifunctional phosphopantothenoylcysteine decarboxylase/phosphopantothenate synthase; Validated; Region: PRK05579
430066003013	Flavoprotein; Region: Flavoprotein; pfam02441
430066003014	DNA / pantothenate metabolism flavoprotein; Region: DFP; pfam04127
430066003015	2-polyprenylphenol 6-hydroxylase; Region: UbiB; TIGR01982
430066003016	ABC1 family; Region: ABC1; pfam03109
430066003017	Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cd05120
430066003018	active site
430066003019	ATP binding site [chemical binding]; other site
430066003020	Protein Kinases, catalytic domain; Region: PKc_like; cl09925
430066003021	substrate binding site [chemical binding]; other site
430066003022	activation loop (A-loop); other site
430066003023	Methylase involved in ubiquinone/menaquinone biosynthesis [Coenzyme metabolism]; Region: UbiE; COG2226
430066003024	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
430066003025	S-adenosylmethionine binding site [chemical binding]; other site
430066003026	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
430066003027	active site
430066003028	hypothetical protein; Provisional; Region: PRK00736
430066003029	methionine sulfoxide reductase A; Provisional; Region: PRK00058
430066003030	putative transposase OrfB; Reviewed; Region: PHA02517
430066003031	HTH-like domain; Region: HTH_21; pfam13276
430066003032	Integrase core domain; Region: rve; pfam00665
430066003033	Integrase core domain; Region: rve_3; pfam13683
430066003034	Transcriptional regulators [Transcription]; Region: GntR; COG1802
430066003035	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
430066003036	DNA-binding site [nucleotide binding]; DNA binding site
430066003037	FCD domain; Region: FCD; pfam07729
430066003038	Aldehyde dehydrogenase family; Region: Aldedh; pfam00171
430066003039	Mitochondrial succinate-semialdehyde dehydrogenase and ALDH family members 5A1 and 5F1-like; Region: ALDH_F5_SSADH_GabD; cd07103
430066003040	tetramerization interface [polypeptide binding]; other site
430066003041	NAD(P) binding site [chemical binding]; other site
430066003042	catalytic residues [active]
430066003043	Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804
430066003044	CoA-transferase family III; Region: CoA_transf_3; pfam02515
430066003045	dipeptide transporter ATP-binding subunit; Provisional; Region: dppF; PRK11308
430066003046	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
430066003047	Walker A/P-loop; other site
430066003048	ATP binding site [chemical binding]; other site
430066003049	Q-loop/lid; other site
430066003050	ABC transporter signature motif; other site
430066003051	Walker B; other site
430066003052	D-loop; other site
430066003053	H-loop/switch region; other site
430066003054	oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727
430066003055	ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444
430066003056	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
430066003057	Walker A/P-loop; other site
430066003058	ATP binding site [chemical binding]; other site
430066003059	Q-loop/lid; other site
430066003060	ABC transporter signature motif; other site
430066003061	Walker B; other site
430066003062	D-loop; other site
430066003063	H-loop/switch region; other site
430066003064	oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727
430066003065	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173
430066003066	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427
430066003067	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601
430066003068	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
430066003069	dimer interface [polypeptide binding]; other site
430066003070	conserved gate region; other site
430066003071	putative PBP binding loops; other site
430066003072	ABC-ATPase subunit interface; other site
430066003073	Transcriptional regulator [Transcription]; Region: IclR; COG1414
430066003074	helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346
430066003075	Bacterial transcriptional regulator; Region: IclR; pfam01614
430066003076	acetoin dehydrogenase E2 subunit dihydrolipoyllysine-residue acetyltransferase; Provisional; Region: PRK14875
430066003077	Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849
430066003078	E3 interaction surface; other site
430066003079	lipoyl attachment site [posttranslational modification]; other site
430066003080	e3 binding domain; Region: E3_binding; pfam02817
430066003081	Serine hydrolase; Region: Ser_hydrolase; cl17834
430066003082	ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747
430066003083	The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_7; cd08512
430066003084	Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000
430066003085	Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, alpha subunit [Energy production and conversion]; Region: AcoA; COG1071
430066003086	TPP-binding site [chemical binding]; other site
430066003087	tetramer interface [polypeptide binding]; other site
430066003088	heterodimer interface [polypeptide binding]; other site
430066003089	phosphorylation loop region [posttranslational modification]
430066003090	Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit [Energy production and conversion]; Region: AcoB; COG0022
430066003091	Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036
430066003092	alpha subunit interface [polypeptide binding]; other site
430066003093	TPP binding site [chemical binding]; other site
430066003094	heterodimer interface [polypeptide binding]; other site
430066003095	Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780
430066003096	Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cl01629
430066003097	3-hydroxy-acyl-CoA dehydrogenase; Validated; Region: PRK08268
430066003098	3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737
430066003099	3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725
430066003100	3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725
430066003101	enoyl-CoA hydratase; Provisional; Region: PRK08138
430066003102	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
430066003103	substrate binding site [chemical binding]; other site
430066003104	oxyanion hole (OAH) forming residues; other site
430066003105	trimer interface [polypeptide binding]; other site
430066003106	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
430066003107	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
430066003108	active site
430066003109	Protein related to penicillin acylase [General function prediction only]; Region: COG2366
430066003110	The Ntn hydrolases (N-terminal nucleophile) are a diverse superfamily of of enzymes that are activated autocatalytically via an N-terminally lcated nucleophilic amino acid.  N-terminal nucleophile (NTN-) hydrolase superfamily, which contains a...; Region: Ntn_hydrolase; cl00467
430066003111	Penicillin G acylase (PGA) belongs to a family of beta-lactam acylases that includes cephalosporin acylase (CA) and aculeacin A acylase. PGA and CA are crucial for the production of backbone chemicals like 6-aminopenicillanic acid and...; Region: Ntn_PGA_like; cd03747
430066003112	active site
430066003113	The Ntn hydrolases (N-terminal nucleophile) are a diverse superfamily of of enzymes that are activated autocatalytically via an N-terminally lcated nucleophilic amino acid.  N-terminal nucleophile (NTN-) hydrolase superfamily, which contains a...; Region: Ntn_hydrolase; cl00467
430066003114	ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747
430066003115	The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_16; cd08502
430066003116	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601
430066003117	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
430066003118	dimer interface [polypeptide binding]; other site
430066003119	conserved gate region; other site
430066003120	putative PBP binding loops; other site
430066003121	ABC-ATPase subunit interface; other site
430066003122	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173
430066003123	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
430066003124	dimer interface [polypeptide binding]; other site
430066003125	conserved gate region; other site
430066003126	putative PBP binding loops; other site
430066003127	ABC-ATPase subunit interface; other site
430066003128	ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444
430066003129	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
430066003130	Walker A/P-loop; other site
430066003131	ATP binding site [chemical binding]; other site
430066003132	Q-loop/lid; other site
430066003133	ABC transporter signature motif; other site
430066003134	Walker B; other site
430066003135	D-loop; other site
430066003136	H-loop/switch region; other site
430066003137	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097
430066003138	ABC-type oligopeptide transport system, ATPase component [Amino acid transport and metabolism]; Region: AppF; COG4608
430066003139	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
430066003140	Walker A/P-loop; other site
430066003141	ATP binding site [chemical binding]; other site
430066003142	Q-loop/lid; other site
430066003143	ABC transporter signature motif; other site
430066003144	Walker B; other site
430066003145	D-loop; other site
430066003146	H-loop/switch region; other site
430066003147	oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727
430066003148	Transcriptional regulators [Transcription]; Region: GntR; COG1802
430066003149	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
430066003150	DNA-binding site [nucleotide binding]; DNA binding site
430066003151	FCD domain; Region: FCD; pfam07729
430066003152	ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747
430066003153	The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_7; cd08512
430066003154	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601
430066003155	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
430066003156	dimer interface [polypeptide binding]; other site
430066003157	conserved gate region; other site
430066003158	putative PBP binding loops; other site
430066003159	ABC-ATPase subunit interface; other site
430066003160	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173
430066003161	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
430066003162	dimer interface [polypeptide binding]; other site
430066003163	conserved gate region; other site
430066003164	putative PBP binding loops; other site
430066003165	ABC-ATPase subunit interface; other site
430066003166	ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444
430066003167	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
430066003168	Walker A/P-loop; other site
430066003169	ATP binding site [chemical binding]; other site
430066003170	Q-loop/lid; other site
430066003171	ABC transporter signature motif; other site
430066003172	Walker B; other site
430066003173	D-loop; other site
430066003174	H-loop/switch region; other site
430066003175	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097
430066003176	ABC-type oligopeptide transport system, ATPase component [Amino acid transport and metabolism]; Region: AppF; COG4608
430066003177	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
430066003178	Walker A/P-loop; other site
430066003179	ATP binding site [chemical binding]; other site
430066003180	Q-loop/lid; other site
430066003181	ABC transporter signature motif; other site
430066003182	Walker B; other site
430066003183	D-loop; other site
430066003184	H-loop/switch region; other site
430066003185	oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727
430066003186	Gluconolactonase [Carbohydrate transport and metabolism]; Region: COG3386
430066003187	amidase; Provisional; Region: PRK07486
430066003188	Amidase; Region: Amidase; cl11426
430066003189	Spermidine/putrescine-binding periplasmic protein [Amino acid transport and metabolism]; Region: PotD; COG0687
430066003190	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199
430066003191	ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177
430066003192	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
430066003193	dimer interface [polypeptide binding]; other site
430066003194	conserved gate region; other site
430066003195	putative PBP binding loops; other site
430066003196	ABC-ATPase subunit interface; other site
430066003197	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
430066003198	dimer interface [polypeptide binding]; other site
430066003199	conserved gate region; other site
430066003200	putative PBP binding loops; other site
430066003201	ABC-ATPase subunit interface; other site
430066003202	ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842
430066003203	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
430066003204	Walker A/P-loop; other site
430066003205	ATP binding site [chemical binding]; other site
430066003206	Q-loop/lid; other site
430066003207	ABC transporter signature motif; other site
430066003208	Walker B; other site
430066003209	D-loop; other site
430066003210	H-loop/switch region; other site
430066003211	TOBE domain; Region: TOBE_2; pfam08402
430066003212	Glutamate-1-semialdehyde aminotransferase [Coenzyme metabolism]; Region: HemL; COG0001
430066003213	Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321
430066003214	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
430066003215	catalytic residue [active]
430066003216	Ribulose-5-phosphate 4-epimerase and related epimerases and aldolases [Carbohydrate transport and metabolism]; Region: AraD; COG0235
430066003217	intersubunit interface [polypeptide binding]; other site
430066003218	active site
430066003219	Zn2+ binding site [ion binding]; other site
430066003220	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3395
430066003221	D-lactate dehydrogenase, membrane binding; Region: Lact-deh-memb; pfam09330
430066003222	putative transposase OrfB; Reviewed; Region: PHA02517
430066003223	HTH-like domain; Region: HTH_21; pfam13276
430066003224	Integrase core domain; Region: rve; pfam00665
430066003225	Integrase core domain; Region: rve_3; pfam13683
430066003226	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012
430066003227	nucleotide binding site [chemical binding]; other site
430066003228	Rrf2 family protein; Region: rrf2_super; TIGR00738
430066003229	Transcriptional regulator; Region: Rrf2; pfam02082
430066003230	Putative GTPases (G3E family) [General function prediction only]; Region: COG0523
430066003231	CobW/HypB/UreG, nucleotide-binding domain; Region: cobW; pfam02492
430066003232	Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; smart00833
430066003233	ABC-type Zn2+ transport system, periplasmic component/surface adhesin [Inorganic ion transport and metabolism]; Region: ZnuA; COG4531
430066003234	Zinc binding protein ZnuA. These proteins have been shown to function as initial receptors in the ABC uptake of Zn2+.  They belong to the TroA superfamily of periplasmic metal binding proteins that share a distinct fold and ligand binding mechanism; Region: ZnuA; cd01019
430066003235	metal binding site [ion binding]; metal-binding site
430066003236	ABC-type Mn/Zn transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: ZnuC; COG1121
430066003237	ATP-binding cassette domain of the metal-type transporters; Region: ABC_Metallic_Cations; cd03235
430066003238	ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108
430066003239	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550
430066003240	ABC-ATPase subunit  interface; other site
430066003241	dimer interface [polypeptide binding]; other site
430066003242	putative PBP binding regions; other site
430066003243	Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153
430066003244	metal binding site 2 [ion binding]; metal-binding site
430066003245	putative DNA binding helix; other site
430066003246	metal binding site 1 [ion binding]; metal-binding site
430066003247	dimer interface [polypeptide binding]; other site
430066003248	structural Zn2+ binding site [ion binding]; other site
430066003249	FlgN protein; Region: FlgN; pfam05130
430066003250	Rod binding protein; Region: Rod-binding; pfam10135
430066003251	Bacterial export proteins, family 1; Region: Bac_export_1; cl00734
430066003252	Bacterial export proteins, family 3; Region: Bac_export_3; cl00867
430066003253	flagellar basal body rod modification protein; Reviewed; Region: flgD; PRK06009
430066003254	Flagellar hook capping protein - N-terminal region; Region: FlgD; pfam03963
430066003255	Flagellar biosynthesis regulator FlbT [Cell motility and secretion]; Region: FlbT; COG5443
430066003256	Flagellar biosynthesis regulator FlaF [Cell motility and secretion]; Region: FlaF; COG5442
430066003257	flagellar biosynthesis regulatory protein FlaF; Reviewed; Region: flaF; PRK12793
430066003258	flagellar hook-associated protein FlgL; Validated; Region: flgL; PRK06008
430066003259	Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669
430066003260	Bacterial flagellin C-terminal helical region; Region: Flagellin_C; pfam00700
430066003261	flagellar hook-associated protein FlgK; Validated; Region: flgK; PRK07521
430066003262	Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; cl15855
430066003263	flagellar hook protein FlgE; Validated; Region: flgE; PRK05682
430066003264	Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460
430066003265	Flagellar basal body protein FlaE; Region: FlaE; pfam07559
430066003266	Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429
430066003267	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
430066003268	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
430066003269	DNA binding site [nucleotide binding]
430066003270	Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741
430066003271	Lytic Transglycosylase (LT)  and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL).  LTs...; Region: LT_GEWL; cd00254
430066003272	N-acetyl-D-glucosamine binding site [chemical binding]; other site
430066003273	Flagellar hook-length control protein FliK; Region: Flg_hook; pfam02120
430066003274	chemotaxis protein; Reviewed; Region: PRK12798
430066003275	flagellar motor protein MotB; Validated; Region: motB; PRK05996
430066003276	Membrane MotB of proton-channel complex MotA/MotB; Region: MotB_plug; pfam13677
430066003277	Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185
430066003278	ligand binding site [chemical binding]; other site
430066003279	flagellar MS-ring protein; Reviewed; Region: fliF; PRK06007
430066003280	Secretory protein of YscJ/FliF family; Region: YscJ_FliF; pfam01514
430066003281	Flagellar M-ring protein C-terminal; Region: YscJ_FliF_C; pfam08345
430066003282	flagellin; Reviewed; Region: PRK12687
430066003283	Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669
430066003284	Autotransporter-associated beta strand repeat; Region: Autotrns_rpt; pfam12951
430066003285	Autotransporter-associated beta strand repeat; Region: Autotrns_rpt; pfam12951
430066003286	Autotransporter-associated beta strand repeat; Region: Autotrns_rpt; cl15373
430066003287	Autotransporter-associated beta strand repeat; Region: Autotrns_rpt; pfam12951
430066003288	Autotransporter-associated beta strand repeat; Region: Autotrns_rpt; pfam12951
430066003289	Autotransporter-associated beta strand repeat; Region: Autotrns_rpt; pfam12951
430066003290	Autotransporter-associated beta strand repeat; Region: Autotrns_rpt; pfam12951
430066003291	Pertactin-like passenger domains (virulence factors), C-terminal, subgroup 2, of autotransporter proteins of the type V secretion system of Gram-negative bacteria. This subgroup includes the passenger domains of the nonprotease autotransporters, Ag43; Region: PL2_Passenger_AT; cd01344
430066003292	outer membrane autotransporter barrel domain; Region: autotrans_barl; TIGR01414
430066003293	Autotransporter beta-domain; Region: Autotransporter; smart00869
430066003294	Uncharacterized conserved protein [Function unknown]; Region: COG3268
430066003295	Periplasmic xylose-binding component of the ABC-type transport systems that belong to a family of pentose/hexose sugar-binding proteins of the type I periplasmic binding protein (PBP1) superfamily; Region: PBP1_ABC_xylose_binding; cd01538
430066003296	D-xylose ABC transporter, substrate-binding protein; Region: xylF; TIGR02634
430066003297	putative ligand binding site [chemical binding]; other site
430066003298	xylose transporter ATP-binding subunit; Provisional; Region: PRK13549
430066003299	First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216
430066003300	Walker A/P-loop; other site
430066003301	ATP binding site [chemical binding]; other site
430066003302	Q-loop/lid; other site
430066003303	ABC transporter signature motif; other site
430066003304	Walker B; other site
430066003305	D-loop; other site
430066003306	H-loop/switch region; other site
430066003307	Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215
430066003308	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
430066003309	Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579
430066003310	Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579
430066003311	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
430066003312	TM-ABC transporter signature motif; other site
430066003313	DNA-binding transcriptional activator FeaR; Provisional; Region: PRK09685
430066003314	HTH domain; Region: HTH_11; cl17392
430066003315	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
430066003316	Aldehyde dehydrogenase family; Region: Aldedh; pfam00171
430066003317	Streptomyces aureofaciens putative aldehyde dehydrogenase AldA (AAD23400)-like; Region: ALDH_AldA-AAD23400; cd07106
430066003318	NAD(P) binding site [chemical binding]; other site
430066003319	catalytic residues [active]
430066003320	2,4-dihydroxyhept-2-ene-1,7-dioic acid aldolase; Region: HpaI; TIGR02311
430066003321	2-oxo-hepta-3-ene-1,7-dioic acid hydratase; Region: HpaH; TIGR02312
430066003322	2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179
430066003323	Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557
430066003324	3,4-dihydroxyphenylacetate 2,3-dioxygenase; Region: HpaD; TIGR02295
430066003325	N-terminal domain of 3,4-dihydroxyphenylacetate 2,3-dioxygenase (HPCD); belongs to the type I class II family of extradiol dioxygenases; Region: HPCD_N_class_II; cd07266
430066003326	tetramer interface [polypeptide binding]; other site
430066003327	C-terminal domain of 3,4-dihydroxyphenylacetate 2,3-dioxygenase (HPCD), which catalyses the second step in the degradation of 4-hydroxyphenylacetate to succinate and pyruvate; belongs to the type I class II family of extradiol dioxygenases; Region: HPCD_C_class_II; cd07256
430066003328	tetramer interface [polypeptide binding]; other site
430066003329	active site
430066003330	metal binding site [ion binding]; metal-binding site
430066003331	5-carboxymethyl-2-hydroxymuconate semialdehyde dehydrogenase; Region: HpaE; TIGR02299
430066003332	Human aldehyde dehydrogenase family 8 member A1-like; Region: ALDH_F8_HMSADH; cd07093
430066003333	NAD binding site [chemical binding]; other site
430066003334	catalytic residues [active]
430066003335	5-carboxymethyl-2-hydroxymuconate isomerase (CHMI) is a trimeric enzyme catalyzing the isomerization of the unsaturated ketone 5-(carboxymethyl)-2-hydroxymuconate to 5-(carboxymethyl)-2-oxo-3-hexene-1,6-dionate. This is one step in the...; Region: CHMI; cd00580
430066003336	putative substrate binding pocket [chemical binding]; other site
430066003337	trimer interface [polypeptide binding]; other site
430066003338	homoprotocatechuate degradation operon regulator, HpaR; Region: HpaR; TIGR02337
430066003339	helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347
430066003340	Putative homoserine kinase type II (protein kinase fold) [General function prediction only]; Region: COG2334
430066003341	Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270
430066003342	active site
430066003343	ATP binding site [chemical binding]; other site
430066003344	substrate binding site [chemical binding]; other site
430066003345	4-aminobutyrate aminotransferase and related aminotransferases [Amino acid transport and metabolism]; Region: GabT; COG0160
430066003346	Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610
430066003347	inhibitor-cofactor binding pocket; inhibition site
430066003348	pyridoxal 5'-phosphate binding site [chemical binding]; other site
430066003349	catalytic residue [active]
430066003350	hypothetical protein; Provisional; Region: PRK07481
430066003351	Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610
430066003352	inhibitor-cofactor binding pocket; inhibition site
430066003353	pyridoxal 5'-phosphate binding site [chemical binding]; other site
430066003354	catalytic residue [active]
430066003355	Haloacid dehalogenase-like hydrolase; Region: HAD_2; pfam13419
430066003356	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
430066003357	motif II; other site
430066003358	Uncharacterized conserved protein [Function unknown]; Region: COG5441; cl02262
430066003359	Uncharacterized protein family (UPF0261); Region: UPF0261; pfam06792
430066003360	IclR helix-turn-helix domain; Region: HTH_IclR; cl17605
430066003361	Transcriptional regulator [Transcription]; Region: IclR; COG1414
430066003362	Bacterial transcriptional regulator; Region: IclR; pfam01614
430066003363	Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531
430066003364	Aldehyde dehydrogenase family; Region: Aldedh; pfam00171
430066003365	Escherichia coli NADP+-dependent gamma-glutamyl-gamma-aminobutyraldehyde dehydrogenase PuuC-like; Region: ALDH_GABALDH-PuuC; cd07112
430066003366	NAD(P) binding site [chemical binding]; other site
430066003367	catalytic residues [active]
430066003368	Predicted metal-dependent hydrolase with the TIM-barrel fold [General function prediction only]; Region: COG1574
430066003369	YtcJ_like metal dependent amidohydrolases. YtcJ is a Bacillus subtilis ORF of unknown function. The Arabidopsis homolog LAF3 has been identified as a factor required for photochrome A signalling; Region: YtcJ_like; cd01300
430066003370	active site
430066003371	Periplasmic binding protein; Region: Peripla_BP_6; pfam13458
430066003372	Type I periplasmic ligand-binding domain of uncharacterized ABC (ATPase Binding Cassette)-type active transport systems that are predicted to be involved in transport of amino acids, peptides, or inorganic ions; Region: PBP1_ABC_ligand_binding_like_7; cd06341
430066003373	putative ligand binding site [chemical binding]; other site
430066003374	Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582
430066003375	TM-ABC transporter signature motif; other site
430066003376	ABC-type branched-chain amino acid transport system, permease component [Amino acid transport and metabolism]; Region: LivM; COG4177
430066003377	Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581
430066003378	TM-ABC transporter signature motif; other site
430066003379	ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411
430066003380	ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219
430066003381	Walker A/P-loop; other site
430066003382	ATP binding site [chemical binding]; other site
430066003383	Q-loop/lid; other site
430066003384	ABC transporter signature motif; other site
430066003385	Walker B; other site
430066003386	D-loop; other site
430066003387	H-loop/switch region; other site
430066003388	ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410
430066003389	ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224
430066003390	Walker A/P-loop; other site
430066003391	ATP binding site [chemical binding]; other site
430066003392	Q-loop/lid; other site
430066003393	ABC transporter signature motif; other site
430066003394	Walker B; other site
430066003395	D-loop; other site
430066003396	H-loop/switch region; other site
430066003397	Protein of unknown function (DUF1634); Region: DUF1634; pfam07843
430066003398	Sulfite exporter TauE/SafE; Region: TauE; pfam01925
430066003399	Transcriptional regulators [Transcription]; Region: PhnF; COG2188
430066003400	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
430066003401	DNA-binding site [nucleotide binding]; DNA binding site
430066003402	UTRA domain; Region: UTRA; pfam07702
430066003403	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653
430066003404	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199
430066003405	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547
430066003406	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653
430066003407	ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395
430066003408	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427
430066003409	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
430066003410	dimer interface [polypeptide binding]; other site
430066003411	conserved gate region; other site
430066003412	putative PBP binding loops; other site
430066003413	ABC-ATPase subunit interface; other site
430066003414	ABC-type sugar transport systems, ATPase components [Carbohydrate transport and metabolism]; Region: MalK; COG3839
430066003415	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
430066003416	Walker A/P-loop; other site
430066003417	ATP binding site [chemical binding]; other site
430066003418	Q-loop/lid; other site
430066003419	ABC transporter signature motif; other site
430066003420	Walker B; other site
430066003421	D-loop; other site
430066003422	H-loop/switch region; other site
430066003423	TOBE domain; Region: TOBE_2; pfam08402
430066003424	metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995
430066003425	Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149
430066003426	active site
430066003427	metal binding site [ion binding]; metal-binding site
430066003428	Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119
430066003429	Sulfatase; Region: Sulfatase; cl17466
430066003430	ABC transporter, substrate-binding protein, aliphatic sulfonates family; Region: SsuA_fam; TIGR01728
430066003431	NMT1-like family; Region: NMT1_2; pfam13379
430066003432	substrate binding pocket [chemical binding]; other site
430066003433	membrane-bound complex binding site; other site
430066003434	hinge residues; other site
430066003435	ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116
430066003436	ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293
430066003437	Walker A/P-loop; other site
430066003438	ATP binding site [chemical binding]; other site
430066003439	Q-loop/lid; other site
430066003440	ABC transporter signature motif; other site
430066003441	Walker B; other site
430066003442	D-loop; other site
430066003443	H-loop/switch region; other site
430066003444	ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600
430066003445	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
430066003446	dimer interface [polypeptide binding]; other site
430066003447	conserved gate region; other site
430066003448	putative PBP binding loops; other site
430066003449	ABC-ATPase subunit interface; other site
430066003450	Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940
430066003451	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012
430066003452	nucleotide binding site [chemical binding]; other site
430066003453	TonB-dependent heme/hemoglobin receptor family protein; Region: TonB-hemin; TIGR01785
430066003454	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
430066003455	N-terminal plug; other site
430066003456	ligand-binding site [chemical binding]; other site
430066003457	AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207
430066003458	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
430066003459	ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683
430066003460	Type I periplasmic ligand-binding domain of uncharacterized ABC (ATPase Binding Cassette)-type active transport systems that are predicted to be involved in transport of amino acids, peptides, or inorganic ions; Region: PBP1_ABC_ligand_binding_like_5; cd06338
430066003461	putative ligand binding site [chemical binding]; other site
430066003462	ABC-type branched-chain amino acid transport system, permease component [Amino acid transport and metabolism]; Region: LivM; COG4177
430066003463	Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581
430066003464	TM-ABC transporter signature motif; other site
430066003465	ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411
430066003466	ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219
430066003467	Walker A/P-loop; other site
430066003468	ATP binding site [chemical binding]; other site
430066003469	Q-loop/lid; other site
430066003470	ABC transporter signature motif; other site
430066003471	Walker B; other site
430066003472	D-loop; other site
430066003473	H-loop/switch region; other site
430066003474	ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410
430066003475	ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224
430066003476	Walker A/P-loop; other site
430066003477	ATP binding site [chemical binding]; other site
430066003478	Q-loop/lid; other site
430066003479	ABC transporter signature motif; other site
430066003480	Walker B; other site
430066003481	D-loop; other site
430066003482	H-loop/switch region; other site
430066003483	coproporphyrinogen III oxidase; Provisional; Region: PRK09249
430066003484	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
430066003485	FeS/SAM binding site; other site
430066003486	HemN C-terminal domain; Region: HemN_C; pfam06969
430066003487	plasmid partitioning protein RepA; Region: partition_RepA; TIGR03453
430066003488	MerR family regulatory protein; Region: MerR; pfam00376
430066003489	ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042
430066003490	P-loop; other site
430066003491	Magnesium ion binding site [ion binding]; other site
430066003492	ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042
430066003493	P-loop; other site
430066003494	Magnesium ion binding site [ion binding]; other site
430066003495	plasmid partitioning protein RepB; Region: partition_RepB; TIGR03454
430066003496	ParB-like nuclease domain; Region: ParB; smart00470
430066003497	DnaA N-terminal domain; Region: DnaA_N; pfam11638
430066003498	chromosomal replication initiator protein DnaA; Region: DnaA; TIGR00362
430066003499	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189
430066003500	Walker A motif; other site
430066003501	ATP binding site [chemical binding]; other site
430066003502	Walker B motif; other site
430066003503	arginine finger; other site
430066003504	C-terminal domain of bacterial DnaA proteins. The DNA-binding C-terminal domain of DnaA contains a helix-turn-helix motif that specifically interacts with the DnaA box, a 9-mer motif that occurs repetitively in the replication origin oriC. Multiple...; Region: Bac_DnaA_C; cd06571
430066003505	DnaA box-binding interface [nucleotide binding]; other site
430066003506	DNA polymerase III subunit beta; Validated; Region: PRK05643
430066003507	Beta clamp domain.  The beta subunit (processivity factor) of DNA polymerase III holoenzyme, refered to as the beta clamp, forms a ring shaped dimer that encircles dsDNA (sliding clamp) in bacteria.  The beta-clamp is structurally similar to the trimeric...; Region: beta_clamp; cd00140
430066003508	putative DNA binding surface [nucleotide binding]; other site
430066003509	dimer interface [polypeptide binding]; other site
430066003510	beta-clamp/clamp loader binding surface; other site
430066003511	beta-clamp/translesion DNA polymerase binding surface; other site
430066003512	recombination protein F; Reviewed; Region: recF; PRK00064
430066003513	ATP-binding cassette domain of RecF; Region: ABC_RecF; cd03242
430066003514	Walker A/P-loop; other site
430066003515	ATP binding site [chemical binding]; other site
430066003516	Q-loop/lid; other site
430066003517	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
430066003518	ABC transporter signature motif; other site
430066003519	Walker B; other site
430066003520	D-loop; other site
430066003521	H-loop/switch region; other site
430066003522	molybdopterin biosynthesis protein MoeB; Provisional; Region: PRK05690
430066003523	ThiF_MoeB_HesA. Family of E1-like enzymes involved in molybdopterin and thiamine biosynthesis family. The common reaction mechanism catalyzed by MoeB and ThiF, like other E1 enzymes, begins with a nucleophilic attack of the C-terminal carboxylate of MoaD...; Region: ThiF_MoeB_HesA_family; cd00757
430066003524	ATP binding site [chemical binding]; other site
430066003525	substrate interface [chemical binding]; other site
430066003526	Phosphoglycerate dehydrogenase and related dehydrogenases [Amino acid transport and metabolism]; Region: SerA; COG0111
430066003527	Putative glycerate dehydrogenase and related proteins of the D-specific 2-hydroxy dehydrogenase family; Region: GDH_like_2; cd12164
430066003528	putative ligand binding site [chemical binding]; other site
430066003529	NAD binding site [chemical binding]; other site
430066003530	dimerization interface [polypeptide binding]; other site
430066003531	catalytic site [active]
430066003532	ABC-type uncharacterized transport system, duplicated ATPase component [General function prediction only]; Region: COG4172
430066003533	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
430066003534	Walker A/P-loop; other site
430066003535	ATP binding site [chemical binding]; other site
430066003536	Q-loop/lid; other site
430066003537	ABC transporter signature motif; other site
430066003538	Walker B; other site
430066003539	D-loop; other site
430066003540	H-loop/switch region; other site
430066003541	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; pfam08352
430066003542	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
430066003543	Walker A/P-loop; other site
430066003544	ATP binding site [chemical binding]; other site
430066003545	Q-loop/lid; other site
430066003546	ABC transporter signature motif; other site
430066003547	Walker B; other site
430066003548	D-loop; other site
430066003549	H-loop/switch region; other site
430066003550	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097
430066003551	ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG4239
430066003552	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
430066003553	dimer interface [polypeptide binding]; other site
430066003554	conserved gate region; other site
430066003555	putative PBP binding loops; other site
430066003556	ABC-ATPase subunit interface; other site
430066003557	ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG4174
430066003558	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
430066003559	dimer interface [polypeptide binding]; other site
430066003560	conserved gate region; other site
430066003561	putative PBP binding loops; other site
430066003562	ABC-ATPase subunit interface; other site
430066003563	ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166
430066003564	The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_14; cd08497
430066003565	ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166
430066003566	The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_14; cd08497
430066003567	Periplasmic binding protein; Region: Peripla_BP_6; pfam13458
430066003568	Type I periplasmic ligand-binding domain of ABC (Atpase Binding Cassette)-type active transport systems that are involved in the transport of all three branched chain aliphatic amino acids (leucine, isoleucine and valine); Region: PBP1_ABC_LIVBP_like; cd06342
430066003569	ligand binding site [chemical binding]; other site
430066003570	dimerization interface [polypeptide binding]; other site
430066003571	enoyl-CoA hydratase; Provisional; Region: PRK07468
430066003572	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
430066003573	substrate binding site [chemical binding]; other site
430066003574	oxyanion hole (OAH) forming residues; other site
430066003575	trimer interface [polypeptide binding]; other site
430066003576	Isopropylmalate/homocitrate/citramalate synthases [Amino acid transport and metabolism]; Region: LeuA; COG0119
430066003577	3-hydroxy-3-methylglutaryl-CoA lyase, catalytic TIM barrel domain; Region: DRE_TIM_HMGL; cd07938
430066003578	active site
430066003579	catalytic residues [active]
430066003580	metal binding site [ion binding]; metal-binding site
430066003581	Acetyl/propionyl-CoA carboxylase, alpha subunit [Lipid metabolism]; Region: COG4770
430066003582	Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289
430066003583	ATP-grasp domain; Region: ATP-grasp_4; cl17255
430066003584	Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878
430066003585	The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850
430066003586	carboxyltransferase (CT) interaction site; other site
430066003587	biotinylation site [posttranslational modification]; other site
430066003588	Carboxyl transferase domain; Region: Carboxyl_trans; pfam01039
430066003589	isovaleryl-CoA dehydrogenase; Region: PLN02519
430066003590	Isovaleryl-CoA dehydrogenase; Region: IVD; cd01156
430066003591	substrate binding site [chemical binding]; other site
430066003592	FAD binding site [chemical binding]; other site
430066003593	catalytic base [active]
430066003594	Acetoacetyl-CoA synthetase (acetoacetate-CoA ligase, AACS); Region: AACS; cd05943
430066003595	Acyl-coenzyme A synthetases/AMP-(fatty) acid ligases [Lipid metabolism]; Region: Acs; COG0365
430066003596	acyl-activating enzyme (AAE) consensus motif; other site
430066003597	putative AMP binding site [chemical binding]; other site
430066003598	putative active site [active]
430066003599	putative CoA binding site [chemical binding]; other site
430066003600	CHRD domain; Region: CHRD; pfam07452
430066003601	Predicted acyltransferases [Lipid metabolism]; Region: COG1835
430066003602	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4530
430066003603	Protein of unknown function (FYDLN_acid); Region: FYDLN_acid; pfam09538
430066003604	3-phosphoshikimate 1-carboxyvinyltransferase; Provisional; Region: PRK02427
430066003605	EPSP synthase domain. 3-phosphoshikimate 1-carboxyvinyltransferase (5-enolpyruvylshikimate-3-phosphate synthase) (EC 2.5.1.19) catalyses the reaction between shikimate-3-phosphate (S3P) and phosphoenolpyruvate (PEP) to form...; Region: EPSP_synthase; cd01556
430066003606	hinge; other site
430066003607	active site
430066003608	cytidylate kinase; Provisional; Region: cmk; PRK00023
430066003609	Cytidine monophosphate kinase (CMPK) catalyzes the reversible phosphorylation of cytidine monophosphate (CMP) to produce cytidine diphosphate (CDP), using ATP as the preferred phosphoryl donor; Region: CMPK; cd02020
430066003610	CMP-binding site; other site
430066003611	The sites determining sugar specificity; other site
430066003612	30S ribosomal protein S1; Reviewed; Region: rpsA; PRK06299
430066003613	S1_RPS1_repeat_ec1_hs1: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec1_hs1; cd05687
430066003614	RNA binding site [nucleotide binding]; other site
430066003615	S1_RPS1_repeat_ec2_hs2: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec2_hs2; cd04465
430066003616	RNA binding site [nucleotide binding]; other site
430066003617	S1_RPS1_repeat_ec3: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec3; cd05688
430066003618	RNA binding site [nucleotide binding]; other site
430066003619	S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927
430066003620	RNA binding site [nucleotide binding]; other site
430066003621	S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927
430066003622	RNA binding site [nucleotide binding]; other site
430066003623	S1_RPS1_repeat_ec6: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec6; cd05691
430066003624	RNA binding site [nucleotide binding]; other site
430066003625	Predicted membrane protein [Function unknown]; Region: COG2855
430066003626	putative DNA-binding transcriptional regulator; Provisional; Region: PRK10837
430066003627	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
430066003628	C-terminal substrate binding domain of LysR-type transcriptional regulator CysL, which activates the transcription of the cysJI operon encoding sulfite reductase, contains the type 2 periplasmic binding fold; Region: PBP2_CysL_like; cd08420
430066003629	putative dimerization interface [polypeptide binding]; other site
430066003630	lytic murein transglycosylase; Region: MltB_2; TIGR02283
430066003631	Lytic Transglycosylase (LT)  and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL).  LTs...; Region: LT_GEWL; cd00254
430066003632	N-acetyl-D-glucosamine binding site [chemical binding]; other site
430066003633	recombination protein RecR; Reviewed; Region: recR; PRK00076
430066003634	RecR protein; Region: RecR; pfam02132
430066003635	TOPRIM_recR: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in Escherichia coli RecR.  RecR participates in the RecFOR pathway of homologous recombinational repair in prokaryotes. This pathway provides a...; Region: TOPRIM_recR; cd01025
430066003636	putative active site [active]
430066003637	putative metal-binding site [ion binding]; other site
430066003638	tetramer interface [polypeptide binding]; other site
430066003639	hypothetical protein; Validated; Region: PRK00153
430066003640	DNA polymerase III subunits gamma and tau; Validated; Region: PRK09111
430066003641	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
430066003642	Walker A motif; other site
430066003643	ATP binding site [chemical binding]; other site
430066003644	Walker B motif; other site
430066003645	arginine finger; other site
430066003646	DNA polymerase III subunits gamma and tau domain III; Region: DNA_pol3_gamma3; pfam12169
430066003647	DNA polymerase III gamma and tau subunits C terminal; Region: DUF3646; pfam12362
430066003648	Diadenosine tetraphosphate (Ap4A) hydrolase and other HIT family hydrolases [Nucleotide transport and metabolism / Carbohydrate transport and metabolism / General function prediction only]; Region: Hit; COG0537
430066003649	NTP pyrophosphohydrolases containing a Zn-finger, probably nucleic-acid-binding [DNA replication, recombination, and repair]; Region: NPY1; COG2816
430066003650	NADH pyrophosphatase-like rudimentary NUDIX domain; Region: NUDIX-like; pfam09296
430066003651	NADH pyrophosphatase zinc ribbon domain; Region: zf-NADH-PPase; pfam09297
430066003652	NADH pyrophosphatase, a member of the Nudix hydrolase superfamily, catalyzes the cleavage of NADH into reduced nicotinamide mononucleotide (NMNH) and AMP. Like other members of the Nudix family, it requires a divalent cation, such as Mg2+ or Mn2+, for...; Region: NADH_pyrophosphatase; cd03429
430066003653	putative NADH binding site [chemical binding]; other site
430066003654	putative active site [active]
430066003655	nudix motif; other site
430066003656	putative metal binding site [ion binding]; other site
430066003657	prephenate dehydratase; Provisional; Region: PRK11899
430066003658	Prephenate dehydratase; Region: PDT; pfam00800
430066003659	C-terminal ACT domain of the bifunctional chorismate mutase-prephenate dehydratase (CM-PDT) enzyme and the prephenate dehydratase (PDT) enzyme; Region: ACT_CM-PDT; cd04905
430066003660	putative L-Phe binding site [chemical binding]; other site
430066003661	3-deoxy-manno-octulosonate cytidylyltransferase; Provisional; Region: PRK05450
430066003662	CMP-KDO synthetase catalyzes the activation of KDO which is an essential component of the lipopolysaccharide; Region: CMP-KDO-Synthetase; cd02517
430066003663	Ligand binding site; other site
430066003664	oligomer interface; other site
430066003665	Cytochrome c2 [Energy production and conversion]; Region: COG3474
430066003666	Molybdopterin biosynthesis enzyme [Coenzyme metabolism]; Region: MoeA; COG0303
430066003667	MoeA_like. This domain is similar to a domain found in a variety of proteins involved in biosynthesis of molybdopterin cofactor, like MoaB, MogA, and MoeA. There this domain is presumed to bind molybdopterin. The exact function of this subgroup is...; Region: MoeA_like; cd03522
430066003668	putative MPT binding site; other site
430066003669	cytochrome o ubiquinol oxidase subunit II; Region: CyoA; TIGR01433
430066003670	Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; pfam00116
430066003671	COX Aromatic Rich Motif; Region: COX_ARM; pfam06481
430066003672	Ubiquinol oxidase subunit III subfamily. Ubiquinol oxidase, the terminal oxidase in the respiratory chains of aerobic bacteria, is a multi-chain transmembrane protein located in the cell membrane.  It catalyzes the reduction of O2 and simultaneously...; Region: Ubiquinol_oxidase_III; cd02863
430066003673	Subunit I/III interface [polypeptide binding]; other site
430066003674	Subunit III/IV interface [polypeptide binding]; other site
430066003675	Heme/copper-type cytochrome/quinol oxidase, subunit 4 [Energy production and conversion]; Region: CyoD; COG3125
430066003676	Bacterial SH3 domain; Region: SH3_3; pfam08239
430066003677	Outer membrane protein [Cell envelope biogenesis, outer membrane]; Region: COG0729
430066003678	Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244
430066003679	Surface antigen; Region: Bac_surface_Ag; pfam01103
430066003680	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2911
430066003681	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2911
430066003682	Family of unknown function (DUF490); Region: DUF490; pfam04357
430066003683	Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376
430066003684	L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734
430066003685	Reeler-like domain of YcnI and similar proteins; Region: YcnI_like; cd08545
430066003686	Copper(I)-binding protein [Inorganic ion transport and    metabolism]; Region: COG2847
430066003687	Glyoxalase I catalyzes the isomerization of the hemithioacetal, formed by a 2-oxoaldehyde and glutathione, to S-D-lactoylglutathione; Region: Glyoxalase_I; cd07233
430066003688	dimer interface [polypeptide binding]; other site
430066003689	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
430066003690	active site
430066003691	metal binding site [ion binding]; metal-binding site
430066003692	glutathione binding site [chemical binding]; other site
430066003693	Domain of unknown function DUF59; Region: DUF59; pfam01883
430066003694	cell division ATPase MinD, archaeal; Region: minD_arch; TIGR01969
430066003695	MRP (Multiple Resistance and pH adaptation) is a homologue of the Fer4_NifH superfamily. Like the other members of the superfamily, MRP contains a ATP-binding domain at the N-termini. It is found in bacteria as a membrane-spanning protein and functions...; Region: MRP-like; cd02037
430066003696	Walker A motif; other site
430066003697	The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203
430066003698	phosphoglucomutase; Region: PLN02307
430066003699	Phosphoglucomutase 1 (PGM1) catalyzes the bidirectional interconversion of glucose-1-phosphate (G-1-P) and glucose-6-phosphate (G-6-P) via a glucose 1,6-diphosphate intermediate, an important metabolic step in prokaryotes and eukaryotes. In one direction; Region: PGM1; cd03085
430066003700	substrate binding site [chemical binding]; other site
430066003701	dimer interface [polypeptide binding]; other site
430066003702	active site
430066003703	metal binding site [ion binding]; metal-binding site
430066003704	Transcriptional regulator [Transcription]; Region: LysR; COG0583
430066003705	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
430066003706	The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_5; cd08474
430066003707	putative effector binding pocket; other site
430066003708	putative dimerization interface [polypeptide binding]; other site
430066003709	Hydrolases of the alpha/beta superfamily [General function prediction only]; Region: COG1073
430066003710	Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326
430066003711	nucleoside triphosphate hydrolase domain-containing protein; Reviewed; Region: PRK09270
430066003712	Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates...; Region: NK; cl17190
430066003713	active site
430066003714	2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179
430066003715	Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557
430066003716	Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741
430066003717	Lytic Transglycosylase (LT)  and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL).  LTs...; Region: LT_GEWL; cd00254
430066003718	N-acetyl-D-glucosamine binding site [chemical binding]; other site
430066003719	catalytic residue [active]
430066003720	Predicted membrane protein, hemolysin III homolog [General function prediction only]; Region: COG1272
430066003721	error-prone DNA polymerase; Validated; Region: dnaE2; PRK05672
430066003722	Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III at DnaE2 gene; Region: PHP_PolIIIA_DnaE2; cd07434
430066003723	putative active site [active]
430066003724	putative PHP Thumb interface [polypeptide binding]; other site
430066003725	DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485
430066003726	generic binding surface II; other site
430066003727	generic binding surface I; other site
430066003728	DNA Polymerase Y-family; Region: PolY_like; cd03468
430066003729	active site
430066003730	Nucleotidyltransferase/DNA polymerase involved in DNA repair [DNA replication, recombination, and repair]; Region: DinP; COG0389
430066003731	DNA binding site [nucleotide binding]
430066003732	Uncharacterized conserved protein [Function unknown]; Region: COG4544
430066003733	Autotransporter adhesin [Intracellular trafficking and secretion / Extracellular structures]; Region: Hia; COG5295
430066003734	Haemagglutinin; Region: HIM; pfam05662
430066003735	Haemagglutinin; Region: HIM; pfam05662
430066003736	YadA-like, left-handed beta-roll; Region: LbR_YadA-like; cd12820
430066003737	trimer interface [polypeptide binding]; other site
430066003738	Haemagglutinin; Region: HIM; pfam05662
430066003739	YadA-like C-terminal region; Region: YadA; pfam03895
430066003740	argininosuccinate synthase; Provisional; Region: PRK13820
430066003741	Argininosuccinate synthase. The Argininosuccinate synthase is a urea cycle enzyme that catalyzes the penultimate step in arginine biosynthesis: the ATP-dependent ligation of citrulline to aspartate to form argininosuccinate, AMP and pyrophosphate .  In...; Region: Argininosuccinate_Synthase; cd01999
430066003742	ANP binding site [chemical binding]; other site
430066003743	Substrate Binding Site II [chemical binding]; other site
430066003744	Substrate Binding Site I [chemical binding]; other site
430066003745	Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280
430066003746	Predicted Fe-S-cluster redox enzyme [General function prediction only]; Region: COG0820
430066003747	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
430066003748	FeS/SAM binding site; other site
430066003749	Invasion associated locus B (IalB) protein; Region: IalB; cl02207
430066003750	Uncharacterized conserved protein [Function unknown]; Region: COG3339
430066003751	PCD_DCoH: The bifunctional protein pterin-4alpha-carbinolamine dehydratase (PCD), also known as DCoH  (dimerization cofactor of hepatocyte nuclear factor-1), is both a transcription activator and a metabolic enzyme.  DCoH stimulates gene expression by...; Region: PCD_DCoH_subfamily_b; cd00914
430066003752	aromatic arch; other site
430066003753	DCoH dimer interaction site [polypeptide binding]; other site
430066003754	DCoH /HNF-1 dimer interaction site [polypeptide binding]; other site
430066003755	DCoH tetramer interaction site [polypeptide binding]; other site
430066003756	substrate binding site [chemical binding]; other site
430066003757	Low molecular weight phosphatase family; Region: LMWPc; cl00105
430066003758	active site
430066003759	2'-5' RNA ligase; Region: 2_5_ligase; TIGR02258
430066003760	LigT like Phosphoesterase; Region: LigT_PEase; pfam02834
430066003761	LigT like Phosphoesterase; Region: LigT_PEase; pfam02834
430066003762	Lysophospholipase L1-like subgroup of SGNH-hydrolases. The best characterized member in this family is TesA, an E. coli periplasmic protein with thioesterase, esterase, arylesterase, protease and lysophospholipase activity; Region: Lysophospholipase_L1_like; cd01822
430066003763	active site
430066003764	catalytic triad [active]
430066003765	oxyanion hole [active]
430066003766	switch loop; other site
430066003767	Predicted ABC-type transport system involved in lysophospholipase L1 biosynthesis, ATPase component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG4181
430066003768	ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255
430066003769	Walker A/P-loop; other site
430066003770	ATP binding site [chemical binding]; other site
430066003771	Q-loop/lid; other site
430066003772	ABC transporter signature motif; other site
430066003773	Walker B; other site
430066003774	D-loop; other site
430066003775	H-loop/switch region; other site
430066003776	Predicted ABC-type transport system involved in lysophospholipase L1 biosynthesis, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3127
430066003777	RNA element found upstream of the uncharacterized YbhL membrane protein in alpha-proteobacteria; BAbS19_Ir0002
430066003778	Integral membrane protein, interacts with FtsH [General function prediction only]; Region: COG0670
430066003779	Bacterial BAX inhibitor (BI)-1/YccA-like proteins; Region: BI-1-like_bacterial; cd10432
430066003780	Protein of unknown function (DUF2794); Region: DUF2794; pfam10984
430066003781	Uncharacterized secreted protein [Function unknown]; Region: COG5429
430066003782	aconitate hydratase; Validated; Region: PRK09277
430066003783	Aconitase A catalytic domain; Region: AcnA_IRP; cd01586
430066003784	substrate binding site [chemical binding]; other site
430066003785	ligand binding site [chemical binding]; other site
430066003786	Aconitase A swivel domain. This is the major form of the TCA cycle enzyme aconitate hydratase, also known as aconitase and citrate hydro-lyase. It includes bacterial and archaeal aconitase A, and the eukaryotic cytosolic form of aconitase. This group...; Region: AcnA_IRP_Swivel; cd01580
430066003787	substrate binding site [chemical binding]; other site
430066003788	cytochrome c biogenesis protein CcmA; Provisional; Region: PRK13539
430066003789	Cytochrome c biogenesis ATP-binding export protein; Region: ABC_CcmA_heme_exporter; cd03231
430066003790	Walker A/P-loop; other site
430066003791	ATP binding site [chemical binding]; other site
430066003792	Q-loop/lid; other site
430066003793	ABC transporter signature motif; other site
430066003794	Walker B; other site
430066003795	D-loop; other site
430066003796	H-loop/switch region; other site
430066003797	ABC-type transport system involved in cytochrome c biogenesis, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CcmB; COG2386
430066003798	heme exporter protein CcmC; Region: ccmC; TIGR01191
430066003799	heme exporter protein CcmD; Region: cytochro_ccmD; TIGR03141
430066003800	periplasmic protein thiol:disulfide oxidoreductases, DsbE subfamily; Region: dsbE; TIGR00385
430066003801	TlpA-like family, DsbE (also known as CcmG and CycY) subfamily; DsbE is a membrane-anchored, periplasmic TRX-like reductase containing a CXXC motif that specifically donates reducing equivalents to apocytochrome c via CcmH, another cytochrome c...; Region: TlpA_like_DsbE; cd03010
430066003802	catalytic residues [active]
430066003803	central insert; other site
430066003804	dihydroxy-acid dehydratase; Provisional; Region: PRK12448
430066003805	DnaJ domain or J-domain.  DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cl02542
430066003806	FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784
430066003807	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
430066003808	active site
430066003809	phosphorylation site [posttranslational modification]
430066003810	intermolecular recognition site; other site
430066003811	Transcriptional regulators [Transcription]; Region: Lrp; COG1522
430066003812	AsnC family; Region: AsnC_trans_reg; pfam01037
430066003813	Domain of Unknown Function (DUF930); Region: DUF930; pfam06059
430066003814	Membrane-bound lysozyme-inhibitor of c-type lysozyme; Region: MliC; cl01604
430066003815	Uncharacterized conserved protein [Function unknown]; Region: COG1434
430066003816	YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259
430066003817	putative active site [active]
430066003818	ABC-type sulfate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: Sbp; COG1613
430066003819	Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531
430066003820	ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555
430066003821	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
430066003822	dimer interface [polypeptide binding]; other site
430066003823	conserved gate region; other site
430066003824	putative PBP binding loops; other site
430066003825	ABC-ATPase subunit interface; other site
430066003826	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
430066003827	dimer interface [polypeptide binding]; other site
430066003828	conserved gate region; other site
430066003829	putative PBP binding loops; other site
430066003830	ABC-ATPase subunit interface; other site
430066003831	ABC-type sulfate/molybdate transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: CysA; COG1118
430066003832	ATP-binding cassette domain of the sulfate transporter; Region: ABC_CysA_sulfate_importer; cd03296
430066003833	Walker A/P-loop; other site
430066003834	ATP binding site [chemical binding]; other site
430066003835	Q-loop/lid; other site
430066003836	ABC transporter signature motif; other site
430066003837	Walker B; other site
430066003838	D-loop; other site
430066003839	H-loop/switch region; other site
430066003840	Glycosyltransferases, probably involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: COG1215
430066003841	Protein of unknown function (DUF3131); Region: DUF3131; pfam11329
430066003842	Putative glucoamylase; Region: Glycoamylase; pfam10091
430066003843	Second GH94N domain of cyclic beta 1-2 glucan synthetase and similar domains; Region: GH94N_ChvB_NdvB_2_like; cd11753
430066003844	Cellobiose phosphorylase [Carbohydrate transport and metabolism]; Region: COG3459
430066003845	First GH94N domain of cyclic beta 1-2 glucan synthetase and similar domains; Region: GH94N_ChvB_NdvB_1_like; cd11756
430066003846	Protein of unknown function, DUF608; Region: DUF608; pfam04685
430066003847	Nicotinic acid phosphoribosyltransferase [Coenzyme metabolism]; Region: PncB; COG1488
430066003848	nicotinate phosphoribosyltransferase; Provisional; Region: PRK05321
430066003849	active site
430066003850	Predicted epimerase, PhzC/PhzF homolog [General function prediction only]; Region: COG0384
430066003851	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
430066003852	S-adenosylmethionine binding site [chemical binding]; other site
430066003853	Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524
430066003854	Fructokinases (FRKs) mainly from bacteria and plants are enzymes with high specificity for fructose, as are all FRKs, but they catalyzes the conversion of fructose to fructose-6-phosphate, which is an entry point into glycolysis via conversion into...; Region: bac_FRK; cd01167
430066003855	putative substrate binding site [chemical binding]; other site
430066003856	putative ATP binding site [chemical binding]; other site
430066003857	Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: FabG; COG1028
430066003858	classical (c) SDRs; Region: SDR_c; cd05233
430066003859	NAD(P) binding site [chemical binding]; other site
430066003860	active site
430066003861	Membrane carboxypeptidase (penicillin-binding protein) [Cell envelope biogenesis, outer membrane]; Region: MrcB; COG0744
430066003862	Transglycosylase; Region: Transgly; pfam00912
430066003863	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905
430066003864	Opacity protein and related surface antigens [Cell envelope biogenesis, outer membrane]; Region: COG3637
430066003865	Opacity protein and related surface antigens [Cell envelope biogenesis, outer membrane]; Region: COG3637
430066003866	Ribonuclease D [Translation, ribosomal structure and biogenesis]; Region: Rnd; COG0349
430066003867	DEDDy 3'-5' exonuclease domain of Ribonuclease D and similar proteins; Region: RNaseD_exo; cd06142
430066003868	catalytic site [active]
430066003869	putative active site [active]
430066003870	putative substrate binding site [chemical binding]; other site
430066003871	hypothetical protein; Validated; Region: PRK09104
430066003872	Uncharacterized M20 Dipeptidases; Region: M20_dipept_like_3; cd05680
430066003873	metal binding site [ion binding]; metal-binding site
430066003874	putative dimer interface [polypeptide binding]; other site
430066003875	DNA polymerase I; Region: pola; TIGR00593
430066003876	PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859
430066003877	active site
430066003878	metal binding site 1 [ion binding]; metal-binding site
430066003879	putative 5' ssDNA interaction site; other site
430066003880	metal binding site 3; metal-binding site
430066003881	metal binding site 2 [ion binding]; metal-binding site
430066003882	H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898
430066003883	putative DNA binding site [nucleotide binding]; other site
430066003884	putative metal binding site [ion binding]; other site
430066003885	DEDDy 3'-5' exonuclease domain of Escherichia coli DNA polymerase I and similar bacterial family-A DNA polymerases; Region: DNA_polA_I_Ecoli_like_exo; cd06139
430066003886	active site
430066003887	catalytic site [active]
430066003888	substrate binding site [chemical binding]; other site
430066003889	Polymerase I functions primarily to fill DNA gaps that arise during DNA repair, recombination and replication; Region: DNA_pol_A_pol_I_C; cd08637
430066003890	active site
430066003891	DNA binding site [nucleotide binding]
430066003892	catalytic site [active]
430066003893	DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker  B motif; Region: DEADc; cd00268
430066003894	DEAD-like helicases superfamily; Region: DEXDc; smart00487
430066003895	ATP binding site [chemical binding]; other site
430066003896	Mg++ binding site [ion binding]; other site
430066003897	motif III; other site
430066003898	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
430066003899	nucleotide binding region [chemical binding]; other site
430066003900	ATP-binding site [chemical binding]; other site
430066003901	RNA recognition motif in the DbpA subfamily of prokaryotic DEAD-box rRNA helicases; Region: RRM_DbpA; cd12252
430066003902	RNA binding site [nucleotide binding]; other site
430066003903	DNA gyrase subunit B; Provisional; Region: gyrB; PRK14939
430066003904	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
430066003905	Mg2+ binding site [ion binding]; other site
430066003906	G-X-G motif; other site
430066003907	TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822
430066003908	anchoring element; other site
430066003909	dimer interface [polypeptide binding]; other site
430066003910	ATP binding site [chemical binding]; other site
430066003911	TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of the...; Region: TOPRIM_TopoIIA_GyrB; cd03366
430066003912	active site
430066003913	putative metal-binding site [ion binding]; other site
430066003914	DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986
430066003915	S-formylglutathione hydrolase; Region: PLN02442
430066003916	S-formylglutathione hydrolase; Region: fghA_ester_D; TIGR02821
430066003917	Acetyltransferases [General function prediction only]; Region: RimI; COG0456
430066003918	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
430066003919	Coenzyme A binding pocket [chemical binding]; other site
430066003920	Zn-dependent alcohol dehydrogenases, class III [Energy production and conversion]; Region: AdhC; COG1062
430066003921	class III alcohol dehydrogenases; Region: alcohol_DH_class_III; cd08300
430066003922	substrate binding site [chemical binding]; other site
430066003923	catalytic Zn binding site [ion binding]; other site
430066003924	NAD binding site [chemical binding]; other site
430066003925	structural Zn binding site [ion binding]; other site
430066003926	dimer interface [polypeptide binding]; other site
430066003927	Transcriptional regulators RcnR and FrmR, and related domains; this domain family was previously known as part of DUF156; Region: RcnR-FrmR-like_DUF156; cd10153
430066003928	putative homodimer interface [polypeptide binding]; other site
430066003929	putative homotetramer interface [polypeptide binding]; other site
430066003930	putative metal binding site [ion binding]; other site
430066003931	putative homodimer-homodimer interface [polypeptide binding]; other site
430066003932	putative allosteric switch controlling residues; other site
430066003933	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
430066003934	ATP binding site [chemical binding]; other site
430066003935	putative Mg++ binding site [ion binding]; other site
430066003936	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
430066003937	nucleotide binding region [chemical binding]; other site
430066003938	ATP-binding site [chemical binding]; other site
430066003939	Helicase associated domain (HA2) Add an annotation; Region: HA2; smart00847
430066003940	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
430066003941	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
430066003942	ATP binding site [chemical binding]; other site
430066003943	Mg2+ binding site [ion binding]; other site
430066003944	G-X-G motif; other site
430066003945	Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340
430066003946	Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586
430066003947	Response regulator consisting of a CheY-like receiver domain and a Fis-type HTH domain [Signal transduction mechanisms / Transcription]; Region: COG4567
430066003948	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
430066003949	active site
430066003950	phosphorylation site [posttranslational modification]
430066003951	intermolecular recognition site; other site
430066003952	dimerization interface [polypeptide binding]; other site
430066003953	PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556
430066003954	Protein of unknown function (DUF1052); Region: DUF1052; pfam06319
430066003955	Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376
430066003956	L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734
430066003957	Scaffold protein Nfu/NifU N terminal; Region: Nfu_N; pfam08712
430066003958	Thioredoxin-like proteins and domains [Posttranslational modification, protein turnover, chaperones]; Region: COG0694
430066003959	Universal stress protein family; Region: Usp; pfam00582
430066003960	Ligand Binding Site [chemical binding]; other site
430066003961	tryptophanyl-tRNA synthetase II; Reviewed; Region: PRK12282
430066003962	catalytic core domain of tryptophanyl-tRNA synthetase; Region: TrpRS_core; cd00806
430066003963	active site
430066003964	HIGH motif; other site
430066003965	dimer interface [polypeptide binding]; other site
430066003966	KMSKS motif; other site
430066003967	Uncharacterized membrane protein, putative virulence factor [General function prediction only]; Region: MviN; COG0728
430066003968	MurJ/MviN, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_MurJ_like; cd13123
430066003969	PII uridylyl-transferase; Provisional; Region: PRK05092
430066003970	Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401
430066003971	metal binding triad; other site
430066003972	GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335
430066003973	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
430066003974	Zn2+ binding site [ion binding]; other site
430066003975	Mg2+ binding site [ion binding]; other site
430066003976	ACT domain family, ACT_UUR-like_1, includes the first of two C-terminal ACT domains of the bacterial signal-transducing uridylyltransferase /uridylyl-removing (UUR) enzyme, GlnD and related domains; Region: ACT_UUR-like_1; cd04900
430066003977	C-terminal ACT domains of the bacterial signal-transducing uridylyltransferase /uridylyl-removing (UUR) enzyme, GlnD and related domains; Region: ACT_ACR-UUR-like_2; cd04899
430066003978	Phosphotransacetylase [Energy production and conversion]; Region: Pta; COG0280
430066003979	Malic enzyme, N-terminal domain; Region: malic; pfam00390
430066003980	NAD(P) binding domain of malic enzyme (ME), subgroup 2; Region: NAD_bind_2_malic_enz; cd05311
430066003981	putative NAD(P) binding site [chemical binding]; other site
430066003982	DNA mismatch repair protein MutS; Provisional; Region: PRK05399
430066003983	MutS domain I; Region: MutS_I; pfam01624
430066003984	MutS domain II; Region: MutS_II; pfam05188
430066003985	MutS domain III; Region: MutS_III; pfam05192
430066003986	ATP-binding cassette domain of MutS1 homolog; Region: ABC_MutS1; cd03284
430066003987	Walker A/P-loop; other site
430066003988	ATP binding site [chemical binding]; other site
430066003989	Q-loop/lid; other site
430066003990	ABC transporter signature motif; other site
430066003991	Walker B; other site
430066003992	D-loop; other site
430066003993	H-loop/switch region; other site
430066003994	Putative hemolysin [General function prediction only]; Region: COG3176
430066003995	lipoprotein signal peptidase; Provisional; Region: PRK14795
430066003996	lipoprotein signal peptidase; Provisional; Region: PRK14787
430066003997	rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566
430066003998	RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; pfam08032
430066003999	SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588
430066004000	Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591
430066004001	IHF dimer interface [polypeptide binding]; other site
430066004002	IHF - DNA interface [nucleotide binding]; other site
430066004003	Signal peptide peptidase A (SppA), a serine protease, has catalytic Ser-Lys dyad; Region: S49_Sppa_N_C; cd07023
430066004004	signal peptide peptidase SppA, 36K type; Region: SppA_dom; TIGR00706
430066004005	tandem repeat interface [polypeptide binding]; other site
430066004006	oligomer interface [polypeptide binding]; other site
430066004007	active site residues [active]
430066004008	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5375
430066004009	Lipopolysaccharide-assembly, LptC-related; Region: LptC; pfam06835
430066004010	lipopolysaccharide transport periplasmic protein LptA; Region: outer_YhbN_LptA; TIGR03002
430066004011	OstA-like protein; Region: OstA; pfam03968
430066004012	ABC-type (unclassified) transport system, ATPase component [General function prediction only]; Region: YhbG; COG1137
430066004013	ATP-binding cassette component of YhbG transport system; Region: ABC_YhbG; cd03218
430066004014	Walker A/P-loop; other site
430066004015	ATP binding site [chemical binding]; other site
430066004016	Q-loop/lid; other site
430066004017	ABC transporter signature motif; other site
430066004018	Walker B; other site
430066004019	D-loop; other site
430066004020	H-loop/switch region; other site
430066004021	RNA polymerase factor sigma-54; Reviewed; Region: PRK05932
430066004022	Sigma-54 factor, Activator interacting domain (AID); Region: Sigma54_AID; pfam00309
430066004023	Sigma-54 factor, core binding domain; Region: Sigma54_CBD; pfam04963
430066004024	Sigma-54, DNA binding domain; Region: Sigma54_DBD; pfam04552
430066004025	RaiA ("ribosome-associated inhibitor A", also known as Protein Y (PY), YfiA, and SpotY,  is a stress-response protein that binds the ribosomal subunit interface and arrests translation by interfering with aminoacyl-tRNA binding to the ribosomal...; Region: RaiA; cd00552
430066004026	30S subunit binding site; other site
430066004027	PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211
430066004028	active site
430066004029	phosphorylation site [posttranslational modification]
430066004030	Uncharacterized small protein [Function unknown]; Region: COG5568
430066004031	Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071
430066004032	Alpha-crystallin domain (ACD) found in Escherichia coli inclusion body-associated proteins IbpA and IbpB, and similar proteins.  IbpA and IbpB are 16 kDa small heat shock proteins (sHsps). sHsps are molecular chaperones that suppress protein aggregation...; Region: ACD_IbpA-B_like; cd06470
430066004033	putative dimer interface [polypeptide binding]; other site
430066004034	Integral membrane protein [Function unknown]; Region: COG5488
430066004035	Predicted EndoIII-related endonuclease [DNA replication, recombination, and repair]; Region: Nth; COG0177
430066004036	endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056
430066004037	minor groove reading motif; other site
430066004038	helix-hairpin-helix signature motif; other site
430066004039	substrate binding pocket [chemical binding]; other site
430066004040	active site
430066004041	Iron-sulfur binding domain of endonuclease III; Region: EndIII_4Fe-2S; pfam10576
430066004042	CysZ-like protein; Reviewed; Region: PRK12768
430066004043	Adenosine kinase (AK) catalyzes the phosphorylation of ribofuranosyl-containing nucleoside analogues at the 5'-hydroxyl using ATP or GTP as the phosphate donor.The physiological function of AK is associated with the regulation of extracellular...; Region: adenosine_kinase; cd01168
430066004044	Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524
430066004045	substrate binding site [chemical binding]; other site
430066004046	ATP binding site [chemical binding]; other site
430066004047	Predicted membrane protein [Function unknown]; Region: COG2860
430066004048	UPF0126 domain; Region: UPF0126; pfam03458
430066004049	UPF0126 domain; Region: UPF0126; pfam03458
430066004050	heat shock protein GrpE; Provisional; Region: PRK14141
430066004051	GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70)-type ATPases. The GrpE dimer binds to the ATPase domain of Hsp70 catalyzing the dissociation of ADP, which enables rebinding of ATP, one step in the Hsp70 reaction cycle in protein folding; Region: GrpE; cd00446
430066004052	dimer interface [polypeptide binding]; other site
430066004053	hsp70 (ATPase domain) interactions [polypeptide binding]; other site
430066004054	heat-inducible transcription repressor; Provisional; Region: hrcA; PRK00082
430066004055	ribonuclease PH; Reviewed; Region: rph; PRK00173
430066004056	Ribonuclease PH; Region: RNase_PH_bact; cd11362
430066004057	hexamer interface [polypeptide binding]; other site
430066004058	active site
430066004059	This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632
430066004060	This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632
430066004061	NTPase/HAM1.  This family consists of the HAM1 protein and pyrophosphate-releasing xanthosine/ inosine triphosphatase. HAM1 protects the cell against mutagenesis by the base analog 6-N-hydroxylaminopurine (HAP) in E. Coli and S. cerevisiae. A...; Region: HAM1; cd00515
430066004062	active site
430066004063	dimerization interface [polypeptide binding]; other site
430066004064	coproporphyrinogen III oxidase; Provisional; Region: PRK09057
430066004065	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
430066004066	FeS/SAM binding site; other site
430066004067	HemN C-terminal domain; Region: HemN_C; pfam06969
430066004068	Predicted methyltransferases [General function prediction only]; Region: COG0313
430066004069	Ribosomal RNA small subunit methyltransferase I, also known as rRNA (cytidine-2'-O-)-methyltransferase RsmI; Region: RsmI; cd11648
430066004070	putative SAM binding site [chemical binding]; other site
430066004071	putative homodimer interface [polypeptide binding]; other site
430066004072	hypothetical protein; Reviewed; Region: PRK12497
430066004073	Siroheme synthase (precorrin-2 oxidase/ferrochelatase domain) [Coenzyme metabolism]; Region: CysG; COG1648
430066004074	Putative NAD(P)-binding; Region: NAD_binding_7; pfam13241
430066004075	Sirohaem synthase dimerisation region; Region: CysG_dimeriser; pfam10414
430066004076	Uroporphyrin-III C-methyltransferase (S-Adenosyl-L-methionine:uroporphyrinogen III methyltransferase, SUMT); Region: SUMT; cd11642
430066004077	active site
430066004078	SAM binding site [chemical binding]; other site
430066004079	homodimer interface [polypeptide binding]; other site
430066004080	Protein of unknown function (DUF2849); Region: DUF2849; pfam11011
430066004081	Sulfite reductase, beta subunit (hemoprotein) [Inorganic ion transport and metabolism]; Region: CysI; COG0155
430066004082	Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460
430066004083	Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460
430066004084	3'-phosphoadenosine 5'-phosphosulfate sulfotransferase (PAPS reductase)/FAD synthetase and related enzymes [Amino acid transport and metabolism / Coenzyme metabolism]; Region: CysH; COG0175
430066004085	This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713
430066004086	Active Sites [active]
430066004087	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3749
430066004088	Stress responsive A/B Barrel Domain; Region: Dabb; pfam07876
430066004089	Methylated DNA-protein cysteine methyltransferase [DNA replication, recombination, and repair]; Region: Ada; COG0350
430066004090	The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445
430066004091	active site
430066004092	DNA binding site [nucleotide binding]
430066004093	BA14K-like protein; Region: BA14K; pfam07886
430066004094	B12-dependent methionine synthase; Provisional; Region: metH; PRK09490
430066004095	Methionine synthase I (cobalamin-dependent), methyltransferase domain [Amino acid transport and metabolism]; Region: MetH; COG0646
430066004096	MeTr subgroup of pterin binding enzymes. This family includes cobalamin-dependent methyltransferases such as methyltetrahydrofolate, corrinoid iron-sulfur protein methyltransferase (MeTr) and methionine synthase (MetH).  Cobalamin-dependent...; Region: MeTr; cd00740
430066004097	substrate binding pocket [chemical binding]; other site
430066004098	B12 binding domain of methionine synthase. This domain binds methylcobalamin, which it uses as an intermediate methyl carrier from methyltetrahydrofolate (CH3H4folate) to homocysteine (Hcy); Region: methionine_synthase_B12_BD; cd02069
430066004099	B12 binding site [chemical binding]; other site
430066004100	cobalt ligand [ion binding]; other site
430066004101	Vitamin B12 dependent methionine synthase, activation domain; Region: Met_synt_B12; pfam02965
430066004102	Autoinducer binding domain; Region: Autoind_bind; pfam03472
430066004103	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
430066004104	DNA binding residues [nucleotide binding]
430066004105	aminotransferase; Provisional; Region: PRK06105
430066004106	Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610
430066004107	inhibitor-cofactor binding pocket; inhibition site
430066004108	pyridoxal 5'-phosphate binding site [chemical binding]; other site
430066004109	catalytic residue [active]
430066004110	sulfate adenylyltransferase, small subunit; Region: CysD; TIGR02039
430066004111	This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713
430066004112	Active Sites [active]
430066004113	bifunctional sulfate adenylyltransferase subunit 1/adenylylsulfate kinase protein; Provisional; Region: PRK05506
430066004114	CysN, together with protein CysD, forms the ATP sulfurylase (ATPS) complex; Region: CysN_ATPS; cd04166
430066004115	CysD dimerization site [polypeptide binding]; other site
430066004116	G1 box; other site
430066004117	putative GEF interaction site [polypeptide binding]; other site
430066004118	GTP/Mg2+ binding site [chemical binding]; other site
430066004119	Switch I region; other site
430066004120	G2 box; other site
430066004121	G3 box; other site
430066004122	Switch II region; other site
430066004123	G4 box; other site
430066004124	G5 box; other site
430066004125	CysN_NodQ_II: This subfamily represents the domain II of the large subunit of ATP sulfurylase (ATPS): CysN or the N-terminal portion of NodQ, found mainly in proteobacteria and homologous to the domain II of EF-Tu. Escherichia coli ATPS consists of CysN...; Region: CysN_NodQ_II; cd03695
430066004126	TCysN_NoDQ_II: This subfamily represents the domain II of the large subunit of ATP sulfurylase (ATPS): CysN or the N-terminal portion of NodQ, found mainly in proteobacteria and homologous to the domain II of EF-Tu. Escherichia coli ATPS consists of CysN...; Region: CysN_NoDQ_III; cd04095
430066004127	Adenosine 5'-phosphosulfate kinase (APSK) catalyzes the phosphorylation of adenosine 5'-phosphosulfate to form 3'-phosphoadenosine 5'-phosphosulfate (PAPS). The end-product PAPS is a biologically "activated" sulfate form...; Region: APSK; cd02027
430066004128	ligand-binding site [chemical binding]; other site
430066004129	CysQ, a 3'-Phosphoadenosine-5'-phosphosulfate (PAPS) 3'-phosphatase, is a bacterial member of the inositol monophosphatase family. It has been proposed that CysQ helps control intracellular levels of PAPS, which is an intermediate in...; Region: CysQ; cd01638
430066004130	Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483
430066004131	active site
430066004132	cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664
430066004133	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
430066004134	ligand binding site [chemical binding]; other site
430066004135	flexible hinge region; other site
430066004136	helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092
430066004137	putative switch regulator; other site
430066004138	non-specific DNA interactions [nucleotide binding]; other site
430066004139	DNA binding site [nucleotide binding]
430066004140	sequence specific DNA binding site [nucleotide binding]; other site
430066004141	putative cAMP binding site [chemical binding]; other site
430066004142	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
430066004143	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cl17736
430066004144	active site
430066004145	dimerization interface [polypeptide binding]; other site
430066004146	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
430066004147	DNA binding residues [nucleotide binding]
430066004148	dimerization interface [polypeptide binding]; other site
430066004149	Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349
430066004150	DeoR-like helix-turn-helix domain; Region: HTH_DeoR; cl17531
430066004151	DeoR C terminal sensor domain; Region: DeoRC; pfam00455
430066004152	glycerol-3-phosphate dehydrogenase; Reviewed; Region: glpD; PRK12266
430066004153	Transcriptional activator of acetoin/glycerol metabolism [Secondary metabolites biosynthesis, transport, and catabolism / Transcription]; Region: AcoR; COG3284
430066004154	GAF domain; Region: GAF; pfam01590
430066004155	Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954
430066004156	Zn-dependent alcohol dehydrogenases [General function prediction only]; Region: AdhP; COG1064
430066004157	Cinnamyl alcohol dehydrogenases (CAD); Region: CAD3; cd08297
430066004158	NAD binding site [chemical binding]; other site
430066004159	substrate binding site [chemical binding]; other site
430066004160	catalytic Zn binding site [ion binding]; other site
430066004161	tetramer interface [polypeptide binding]; other site
430066004162	structural Zn binding site [ion binding]; other site
430066004163	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3564
430066004164	Transcriptional regulators [Transcription]; Region: PurR; COG1609
430066004165	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
430066004166	DNA binding site [nucleotide binding]
430066004167	domain linker motif; other site
430066004168	Ligand-binding domain of DNA transcription repressor SalR, a member of the LacI-GalR family of bacterial transcription regulators; Region: PBP1_SalR; cd01545
430066004169	putative dimerization interface [polypeptide binding]; other site
430066004170	putative ligand binding site [chemical binding]; other site
430066004171	Bacillus subtilis NADP+-dependent alpha-ketoglutaric semialdehyde dehydrogenase ycbD-like; Region: ALDH_KGSADH-YcbD; cd07097
430066004172	Aldehyde dehydrogenase family; Region: Aldedh; pfam00171
430066004173	NAD(P) binding site [chemical binding]; other site
430066004174	catalytic residues [active]
430066004175	ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600
430066004176	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
430066004177	dimer interface [polypeptide binding]; other site
430066004178	conserved gate region; other site
430066004179	putative PBP binding loops; other site
430066004180	ABC-ATPase subunit interface; other site
430066004181	Putative transcription activator [Transcription]; Region: TenA; COG0819
430066004182	NMT1/THI5 like; Region: NMT1; pfam09084
430066004183	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cl17432
430066004184	Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5-; Region: TMP_TenI; cd00564
430066004185	active site
430066004186	thiamine phosphate binding site [chemical binding]; other site
430066004187	pyrophosphate binding site [ion binding]; other site
430066004188	Thiazole synthase (ThiG) is the tetrameric enzyme that is involved in the formation of the thiazole moiety of thiamin pyrophosphate, an essential ubiquitous cofactor that plays an important role in carbohydrate and amino acid metabolism. ThiG catalyzes...; Region: ThiG; cd04728
430066004189	ThiS interaction site; other site
430066004190	putative active site [active]
430066004191	tetramer interface [polypeptide binding]; other site
430066004192	ThiaminS ubiquitin-like sulfur carrier protein; Region: ThiS; cd00565
430066004193	thiS-thiF/thiG interaction site; other site
430066004194	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
430066004195	glycine oxidase ThiO; Region: thiamin_ThiO; TIGR02352
430066004196	4-amino-5-hydroxymethyl-2-methyl-pyrimidine phosphate kinase (HMPP-kinase) catalyzes two consecutive phosphorylation steps in the thiamine phosphate biosynthesis pathway, leading to the synthesis of vitamin B1. The first step is the phosphorylation of...; Region: HMPP_kinase; cd01169
430066004197	dimer interface [polypeptide binding]; other site
430066004198	substrate binding site [chemical binding]; other site
430066004199	ATP binding site [chemical binding]; other site
430066004200	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
430066004201	FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202
430066004202	putative active site [active]
430066004203	heme pocket [chemical binding]; other site
430066004204	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
430066004205	putative active site [active]
430066004206	heme pocket [chemical binding]; other site
430066004207	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
430066004208	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
430066004209	metal binding site [ion binding]; metal-binding site
430066004210	active site
430066004211	I-site; other site
430066004212	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
430066004213	Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371
430066004214	Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217
430066004215	metal-binding site [ion binding]
430066004216	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
430066004217	Cu(I)-responsive transcriptional regulator; Region: CueR; TIGR02044
430066004218	Helix-Turn-Helix DNA binding domain of CueR-like transcription regulators; Region: HTH_CueR; cd01108
430066004219	DNA binding residues [nucleotide binding]
430066004220	dimer interface [polypeptide binding]; other site
430066004221	copper binding site [ion binding]; other site
430066004222	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
430066004223	dimer interface [polypeptide binding]; other site
430066004224	conserved gate region; other site
430066004225	putative PBP binding loops; other site
430066004226	ABC-ATPase subunit interface; other site
430066004227	ABC-type proline/glycine betaine transport systems, ATPase components [Amino acid transport and metabolism]; Region: OpuBA; COG1125
430066004228	ATP-binding cassette domain of the osmoprotectant transporter; Region: ABC_OpuCA_Osmoprotection; cd03295
430066004229	Walker A/P-loop; other site
430066004230	ATP binding site [chemical binding]; other site
430066004231	Q-loop/lid; other site
430066004232	ABC transporter signature motif; other site
430066004233	Walker B; other site
430066004234	D-loop; other site
430066004235	H-loop/switch region; other site
430066004236	The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354
430066004237	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
430066004238	dimer interface [polypeptide binding]; other site
430066004239	conserved gate region; other site
430066004240	ABC-ATPase subunit interface; other site
430066004241	Periplasmic glycine betaine/choline-binding (lipo)protein of an ABC-type transport system (osmoprotectant binding protein) [Cell envelope biogenesis, outer membrane]; Region: OpuBC; COG1732
430066004242	Uncharacterized conserved protein [Function unknown]; Region: COG5514
430066004243	heme-binding site [chemical binding]; other site
430066004244	Glutamate dehydrogenase/leucine dehydrogenase [Amino acid transport and metabolism]; Region: GdhA; COG0334
430066004245	Glu/Leu/Phe/Val dehydrogenase, dimerisation domain; Region: ELFV_dehydrog_N; pfam02812
430066004246	NAD(P) binding domain of glutamate dehydrogenase, subgroup 1; Region: NAD_bind_1_Glu_DH; cd01076
430066004247	NAD(P) binding site [chemical binding]; other site
430066004248	sarcosine oxidase, beta subunit family, heterotetrameric form; Region: soxB; TIGR01373
430066004249	hydroxyglutarate oxidase; Provisional; Region: PRK11728
430066004250	Sarcosine oxidase delta subunit [Amino acid transport and metabolism]; Region: SoxD; COG4311
430066004251	Sarcosine oxidase gamma subunit [Amino acid transport and metabolism]; Region: COG4583
430066004252	Predicted metal-dependent hydrolase of the TIM-barrel fold [General function prediction only]; Region: COG3618
430066004253	Amidohydrolase; Region: Amidohydro_2; pfam04909
430066004254	active site
430066004255	Transcriptional regulator [Transcription]; Region: IclR; COG1414
430066004256	helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346
430066004257	Bacterial transcriptional regulator; Region: IclR; pfam01614
430066004258	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653
430066004259	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547
430066004260	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
430066004261	dimer interface [polypeptide binding]; other site
430066004262	conserved gate region; other site
430066004263	putative PBP binding loops; other site
430066004264	ABC-ATPase subunit interface; other site
430066004265	ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395
430066004266	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
430066004267	dimer interface [polypeptide binding]; other site
430066004268	conserved gate region; other site
430066004269	putative PBP binding loops; other site
430066004270	ABC-ATPase subunit interface; other site
430066004271	glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650
430066004272	The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301
430066004273	Walker A/P-loop; other site
430066004274	ATP binding site [chemical binding]; other site
430066004275	Q-loop/lid; other site
430066004276	ABC transporter signature motif; other site
430066004277	Walker B; other site
430066004278	D-loop; other site
430066004279	H-loop/switch region; other site
430066004280	TOBE domain; Region: TOBE_2; pfam08402
430066004281	L-alanine-DL-glutamate epimerase and related enzymes of enolase superfamily [Cell envelope biogenesis, outer membrane / General function prediction only]; Region: COG4948
430066004282	Mandelate racemase (MR)-like subfamily of the enolase superfamily. Enzymes of this subgroup share three conserved carboxylate ligands for the essential divalent metal ion (usually Mg2+), two aspartates and a glutamate, and conserved catalytic residues; Region: MR_like; cd03316
430066004283	active site pocket [active]
430066004284	Uncharacterized conserved protein [Function unknown]; Region: COG3254
430066004285	Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673
430066004286	Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408
430066004287	3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK05565
430066004288	human DHRS6-like, classical (c) SDRs; Region: DHRS6_like_SDR_c; cd05368
430066004289	NAD binding site [chemical binding]; other site
430066004290	homotetramer interface [polypeptide binding]; other site
430066004291	homodimer interface [polypeptide binding]; other site
430066004292	active site
430066004293	2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179
430066004294	Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557
430066004295	L-alanine-DL-glutamate epimerase and related enzymes of enolase superfamily [Cell envelope biogenesis, outer membrane / General function prediction only]; Region: COG4948
430066004296	Human rTS beta is encoded by the rTS gene which, through alternative RNA splicing, also encodes rTS alpha whose mRNA is complementary to thymidylate synthase mRNA. rTS beta expression is associated with the production of small molecules that appear to...; Region: rTSbeta_L-fuconate_dehydratase; cd03324
430066004297	putative active site pocket [active]
430066004298	metal binding site [ion binding]; metal-binding site
430066004299	integrase; Provisional; Region: PRK09692
430066004300	Bacteriophage P4 integrase. P4-like integrases are found in temperate bacteriophages, integrative plasmids, pathogenicity and symbiosis islands, and other mobile genetic elements.  They share the same fold in their catalytic domain and the overall...; Region: INT_P4; cd00801
430066004301	active site
430066004302	Int/Topo IB signature motif; other site
430066004303	Predicted transcriptional regulator [Transcription]; Region: AlpA; COG3311
430066004304	Toprim domain; Region: Toprim_3; pfam13362
430066004305	Winged helix-turn-helix DNA-binding; Region: HTH_24; pfam13412
430066004306	Ribbon-helix-helix protein, copG family; Region: RHH_1; pfam01402
430066004307	Muramidase (flagellum-specific) [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FlgJ; COG1705
430066004308	Predicted Zn peptidase [Amino acid transport and metabolism]; Region: COG2856
430066004309	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl17200
430066004310	non-specific DNA binding site [nucleotide binding]; other site
430066004311	salt bridge; other site
430066004312	sequence-specific DNA binding site [nucleotide binding]; other site
430066004313	TIR domain; Region: TIR_2; pfam13676
430066004314	zinc-binding protein; Provisional; Region: PRK01343
430066004315	Maf-like protein; Region: Maf; pfam02545
430066004316	Nucleotide binding protein Maf. Maf has been implicated in inhibition of septum formation in eukaryotes, bacteria and archaea, but homologs in B.subtilis and S.cerevisiae are nonessential for cell division. Maf has been predicted to be a nucleotide- or...; Region: Maf; cd00555
430066004317	active site
430066004318	dimer interface [polypeptide binding]; other site
430066004319	S1_IF1: Translation Initiation Factor IF1, S1-like RNA-binding domain. IF1 contains an S1-like RNA-binding domain, which is found in a wide variety of RNA-associated proteins. Translation initiation includes a number of interrelated steps preceding the...; Region: S1_IF1; cd04451
430066004320	rRNA binding site [nucleotide binding]; other site
430066004321	predicted 30S ribosome binding site; other site
430066004322	Protein-tyrosine-phosphatase [Signal transduction mechanisms]; Region: Wzb; COG0394
430066004323	Low molecular weight phosphatase family; Region: LMWPc; cd00115
430066004324	active site
430066004325	hypothetical protein; Provisional; Region: PRK02853
430066004326	Histidinol dehydrogenase [Amino acid transport and metabolism]; Region: HisD; COG0141
430066004327	Histidinol dehydrogenase, HisD, E.C 1.1.1.23. Histidinol dehydrogenase catalyzes the last two steps in the L-histidine biosynthesis pathway, which is conserved in bacteria, archaea, fungi, and plants. These last two steps are (i) the NAD-dependent...; Region: Histidinol_dh; cd06572
430066004328	NAD binding site [chemical binding]; other site
430066004329	dimerization interface [polypeptide binding]; other site
430066004330	product binding site; other site
430066004331	substrate binding site [chemical binding]; other site
430066004332	zinc binding site [ion binding]; other site
430066004333	catalytic residues [active]
430066004334	Protein of unknown function (DUF2948); Region: DUF2948; pfam11164
430066004335	UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Region: murA; TIGR01072
430066004336	UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555
430066004337	hinge; other site
430066004338	active site
430066004339	Integrase [DNA replication, recombination, and repair]; Region: XerC; COG0582
430066004340	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
430066004341	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
430066004342	active site
430066004343	DNA binding site [nucleotide binding]
430066004344	Int/Topo IB signature motif; other site
430066004345	BRO family, N-terminal domain; Region: Bro-N; cl10591
430066004346	Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and...; Region: SR_ResInv; cd03768
430066004347	Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961
430066004348	catalytic residues [active]
430066004349	catalytic nucleophile [active]
430066004350	Presynaptic Site I dimer interface [polypeptide binding]; other site
430066004351	Synaptic Antiparallel dimer interface [polypeptide binding]; other site
430066004352	Synaptic Flat tetramer interface [polypeptide binding]; other site
430066004353	Synaptic Site I dimer interface [polypeptide binding]; other site
430066004354	DNA binding site [nucleotide binding]
430066004355	Urease accessory protein UreH [Posttranslational modification, protein turnover, chaperones]; Region: UreH; COG0829
430066004356	Urease gamma-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, archaea, fungi and plants. Their primary role is to allow the use...; Region: Urease_gamma; cd00390
430066004357	alpha-gamma subunit interface [polypeptide binding]; other site
430066004358	beta-gamma subunit interface [polypeptide binding]; other site
430066004359	Urease beta-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, archaea, fungi and plants. Their primary role is to allow the use of...; Region: Urease_beta; cd00407
430066004360	gamma-beta subunit interface [polypeptide binding]; other site
430066004361	alpha-beta subunit interface [polypeptide binding]; other site
430066004362	urease subunit alpha; Reviewed; Region: ureC; PRK13207
430066004363	Urease alpha-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, fungi and plants. Their primary role is to allow the use of...; Region: Urease_alpha; cd00375
430066004364	subunit interactions [polypeptide binding]; other site
430066004365	active site
430066004366	flap region; other site
430066004367	Urease accessory protein UreE [Posttranslational modification, protein turnover, chaperones]; Region: UreE; COG2371
430066004368	UreE urease accessory protein. UreE is a metallochaperone assisting the insertion of a Ni2+ ion in the active site of urease, an important step in the in vivo assembly of urease, an enzyme that hydrolyses urea into ammonia and carbamic acid. The...; Region: UreE; cd00571
430066004369	dimer interface [polypeptide binding]; other site
430066004370	catalytic residues [active]
430066004371	Urease accessory protein UreF [Posttranslational modification, protein turnover, chaperones]; Region: UreF; COG0830
430066004372	UreF; Region: UreF; pfam01730
430066004373	The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203
430066004374	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
430066004375	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
430066004376	ATP binding site [chemical binding]; other site
430066004377	Mg2+ binding site [ion binding]; other site
430066004378	G-X-G motif; other site
430066004379	RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730
430066004380	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
430066004381	HlyD family secretion protein; Region: HlyD_3; pfam13437
430066004382	Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841
430066004383	allantoate amidohydrolase; Reviewed; Region: PRK12893
430066004384	M20 Peptidase beta-alanine synthase, an amidohydrolase; Region: M20_bAS; cd03884
430066004385	active site
430066004386	metal binding site [ion binding]; metal-binding site
430066004387	dimer interface [polypeptide binding]; other site
430066004388	pyrimidine utilization regulatory protein R; Region: RutR; TIGR03613
430066004389	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
430066004390	YcdC-like protein, C-terminal region; Region: TetR_C_3; pfam08362
430066004391	dihydropyrimidine dehydrogenase subunit B; Validated; Region: PRK08318
430066004392	Dihydropyrimidine dehydrogenase (DHPD) FMN-binding domain.  DHPD catalyzes the first step in pyrimidine degradation: the NADPH-dependent reduction of uracil and thymine to the corresponding 5,6-dihydropyrimidines. DHPD contains two FAD, two FMN, and...; Region: DHPD_FMN; cd02940
430066004393	homodimer interface [polypeptide binding]; other site
430066004394	active site
430066004395	FMN binding site [chemical binding]; other site
430066004396	substrate binding site [chemical binding]; other site
430066004397	4Fe-4S binding domain; Region: Fer4; cl02805
430066004398	4Fe-4S binding domain; Region: Fer4; pfam00037
430066004399	dihydropyrimidine dehydrogenase subunit A; Provisional; Region: PRK11749
430066004400	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
430066004401	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
430066004402	Carbon monoxide dehydrogenase subunit G (CoxG); Region: CoxG; cd05018
430066004403	putative hydrophobic ligand binding site [chemical binding]; other site
430066004404	glucose-6-phosphate isomerase; Reviewed; Region: pgi; PRK00179
430066004405	Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the first SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_1; cd05015
430066004406	active site
430066004407	dimer interface [polypeptide binding]; other site
430066004408	Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the second SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_2; cd05016
430066004409	dimer interface [polypeptide binding]; other site
430066004410	active site
430066004411	Predicted deacylase [General function prediction only]; Region: COG3608
430066004412	Peptidase M14 Succinylglutamate desuccinylase (ASTE)/aspartoacylase (ASPA)-like subfamily; subgroup includes Pseudomonas aeruginosa AotO; Region: M14_PaAOTO_like; cd06250
430066004413	active site
430066004414	Zn binding site [ion binding]; other site
430066004415	Predicted phosphatases [General function prediction only]; Region: Gph; COG0546
430066004416	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
430066004417	motif II; other site
430066004418	HAD-hyrolase-like; Region: Hydrolase_like; pfam13242
430066004419	Predicted alpha/beta hydrolase [General function prediction only]; Region: COG4757
430066004420	Long-chain-fatty-acid--CoA ligase; Validated; Region: PRK07059
430066004421	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
430066004422	Prokaryotic long-chain fatty acid CoA synthetases similar to Escherichia coli FadD; Region: FC-FACS_FadD_like; cd05936
430066004423	acyl-activating enzyme (AAE) consensus motif; other site
430066004424	putative AMP binding site [chemical binding]; other site
430066004425	putative active site [active]
430066004426	putative CoA binding site [chemical binding]; other site
430066004427	DNA-binding transcriptional repressor AcrR; Provisional; Region: PRK10668
430066004428	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
430066004429	MAATS-type transcriptional repressor, C-terminal region; Region: TetR_C_2; pfam08361
430066004430	RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730
430066004431	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
430066004432	HlyD family secretion protein; Region: HlyD_3; pfam13437
430066004433	The (Largely Gram-negative Bacterial) Hydrophobe/Amphiphile Efflux-1 (HAE1) Family; Region: 2A0602; TIGR00915
430066004434	Protein export membrane protein; Region: SecD_SecF; cl14618
430066004435	Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497
430066004436	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
430066004437	substrate binding pocket [chemical binding]; other site
430066004438	membrane-bound complex binding site; other site
430066004439	Glycosyltransferases, probably involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: COG1215
430066004440	CESA_like_2 is a member of the cellulose synthase superfamily; Region: CESA_like_2; cd06427
430066004441	DXD motif; other site
430066004442	Uncharacterized conserved protein [Function unknown]; Region: COG2326
430066004443	phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966
430066004444	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
430066004445	dimer interface [polypeptide binding]; other site
430066004446	phosphorylation site [posttranslational modification]
430066004447	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
430066004448	ATP binding site [chemical binding]; other site
430066004449	Mg2+ binding site [ion binding]; other site
430066004450	G-X-G motif; other site
430066004451	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5352
430066004452	acetylornithine transaminase protein; Provisional; Region: argD; PRK01278
430066004453	Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610
430066004454	inhibitor-cofactor binding pocket; inhibition site
430066004455	pyridoxal 5'-phosphate binding site [chemical binding]; other site
430066004456	catalytic residue [active]
430066004457	ornithine carbamoyltransferase; Provisional; Region: PRK00779
430066004458	Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729
430066004459	Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185
430066004460	Heat shock protein 33 (Hsp33):  Cytosolic protein that acts as a molecular chaperone under oxidative conditions.  In normal (reducing) cytosolic conditions, four conserved Cys residues are coordinated by a Zn ion. Under oxidative stress (such as heat...; Region: Hsp33; cd00498
430066004461	Hsp33-like chaperonin; Reviewed; Region: hslO; PRK00114
430066004462	dimerization interface [polypeptide binding]; other site
430066004463	domain crossover interface; other site
430066004464	redox-dependent activation switch; other site
430066004465	CO2+/MG2+ efflux protein ApaG; Reviewed; Region: apaG; PRK05461
430066004466	O-succinylhomoserine sulfhydrylase; Reviewed; Region: PRK07504
430066004467	CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614
430066004468	homodimer interface [polypeptide binding]; other site
430066004469	substrate-cofactor binding pocket; other site
430066004470	pyridoxal 5'-phosphate binding site [chemical binding]; other site
430066004471	catalytic residue [active]
430066004472	2'-deoxycytidine 5'-triphosphate deaminase; Provisional; Region: PRK07559
430066004473	Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cl00493
430066004474	trimer interface [polypeptide binding]; other site
430066004475	active site
430066004476	Deoxycytidine deaminase [Nucleotide transport and metabolism]; Region: Dcd; COG0717
430066004477	trimer interface [polypeptide binding]; other site
430066004478	active site
430066004479	Transcriptional regulator containing an amidase domain and an AraC-type DNA-binding HTH domain [Transcription]; Region: COG4977
430066004480	AraC transcriptional regulators having an N-terminal Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GATase1_AraC_ArgR_like; cd03136
430066004481	conserved cys residue [active]
430066004482	Uncharacterized protein with SCP/PR1 domains [Function unknown]; Region: COG2340
430066004483	SCP_bacterial: SCP-like extracellular protein domain, as found in bacteria and archaea. The wider family of SCP containing proteins includes plant pathogenesis-related protein 1 (PR-1), CRISPs, mammalian cysteine-rich secretory proteins, and allergen 5...; Region: SCP_bacterial; cd05379
430066004484	DinF and similar proteins, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_DinF_like; cd13136
430066004485	DNA-damage-inducible SOS response protein; Provisional; Region: PRK10367
430066004486	dihydroorotate dehydrogenase 2; Reviewed; Region: PRK05286
430066004487	Dihydroorotate dehydrogenase (DHOD) class 2. DHOD catalyzes the oxidation of (S)-dihydroorotate to orotate. This is the fourth step and the only redox reaction in the de novo biosynthesis of UMP, the precursor of all pyrimidine nucleotides. DHOD requires...; Region: DHOD_2_like; cd04738
430066004488	quinone interaction residues [chemical binding]; other site
430066004489	active site
430066004490	catalytic residues [active]
430066004491	FMN binding site [chemical binding]; other site
430066004492	substrate binding site [chemical binding]; other site
430066004493	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3502
430066004494	proline iminopeptidase, Neisseria-type subfamily; Region: pro_imino_pep_1; TIGR01249
430066004495	homoserine O-acetyltransferase; Provisional; Region: metX; cl17114
430066004496	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
430066004497	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
430066004498	active site
430066004499	phosphorylation site [posttranslational modification]
430066004500	intermolecular recognition site; other site
430066004501	dimerization interface [polypeptide binding]; other site
430066004502	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
430066004503	DNA binding residues [nucleotide binding]
430066004504	dimerization interface [polypeptide binding]; other site
430066004505	Na+/proline symporter [Amino acid transport and metabolism / General function prediction only]; Region: PutP; COG0591
430066004506	Na binding site [ion binding]; other site
430066004507	PAS fold; Region: PAS_7; pfam12860
430066004508	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
430066004509	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
430066004510	dimer interface [polypeptide binding]; other site
430066004511	phosphorylation site [posttranslational modification]
430066004512	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
430066004513	ATP binding site [chemical binding]; other site
430066004514	Mg2+ binding site [ion binding]; other site
430066004515	G-X-G motif; other site
430066004516	FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784
430066004517	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
430066004518	active site
430066004519	phosphorylation site [posttranslational modification]
430066004520	intermolecular recognition site; other site
430066004521	dimerization interface [polypeptide binding]; other site
430066004522	large-conductance mechanosensitive channel; Reviewed; Region: mscL; PRK00567
430066004523	large-conductance mechanosensitive channel; Provisional; Region: mscL; PRK13952
430066004524	pyridoxal phosphate-dependent acyltransferase, putative; Region: gly_Cac_T_rel; TIGR01825
430066004525	KBL_like; this family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to serine palmitoyltransferase (SPT), 5-aminolevulinate synthase (ALAS); Region: KBL_like; cd06454
430066004526	substrate-cofactor binding pocket; other site
430066004527	pyridoxal 5'-phosphate binding site [chemical binding]; other site
430066004528	catalytic residue [active]
430066004529	Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726
430066004530	Putative catalytic NodB homology domain of PgaB, IcaB, and similar proteins which consist of a deformed (beta/alpha)8 barrel fold with 5- or 6-strands; Region: CE4_NodB_like_5s_6s; cd10918
430066004531	putative active site [active]
430066004532	putative metal binding site [ion binding]; other site
430066004533	Glycosyltransferase family 25 [lipooligosaccharide (LOS) biosynthesis protein] is a family of glycosyltransferases involved in LOS biosynthesis. The members include the beta(1,4) galactosyltransferases: Lgt2 of Moraxella catarrhalis, LgtB and LgtE of...; Region: Glyco_transf_25; cd06532
430066004534	Glycosyltransferase family 29 (sialyltransferase); Region: Glyco_transf_29; pfam00777
430066004535	Transcriptional regulator [Transcription]; Region: LysR; COG0583
430066004536	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
430066004537	The C-terminal substrate binding domain of LysR-like transcriptional regulator CidR, contains the type 2 periplasmic binding fold; Region: PBP2_CidR; cd08438
430066004538	putative dimerization interface [polypeptide binding]; other site
430066004539	Putative effector of murein hydrolase LrgA [General function prediction only]; Region: COG1380
430066004540	Putative effector of murein hydrolase [Cell envelope biogenesis, outer membrane]; Region: LrgB; COG1346
430066004541	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4782
430066004542	pantoate--beta-alanine ligase; Region: panC; TIGR00018
430066004543	Pantoate-beta-alanine ligase; Region: PanC; cd00560
430066004544	active site
430066004545	ATP-binding site [chemical binding]; other site
430066004546	pantoate-binding site; other site
430066004547	HXXH motif; other site
430066004548	Ketopantoate hydroxymethyltransferase (KPHMT) is the first enzyme in the pantothenate biosynthesis pathway. Ketopantoate hydroxymethyltransferase (KPHMT) catalyzes the first committed step in the biosynthesis of pantothenate (vitamin B5), which is a...; Region: KPHMT-like; cd06557
430066004549	active site
430066004550	oligomerization interface [polypeptide binding]; other site
430066004551	metal binding site [ion binding]; metal-binding site
430066004552	Flavodoxin reductases (ferredoxin-NADPH reductases) family 1 [Energy production and conversion]; Region: Hmp; COG1018
430066004553	Ferredoxin-NADP+ (oxido)reductase is an FAD-containing enzyme that catalyzes the reversible electron transfer between NADP(H) and electron carrier proteins such as ferredoxin and flavodoxin. Isoforms of these flavoproteins (i.e. having a non-covalently...; Region: FNR1; cd06195
430066004554	FAD binding pocket [chemical binding]; other site
430066004555	FAD binding motif [chemical binding]; other site
430066004556	phosphate binding motif [ion binding]; other site
430066004557	beta-alpha-beta structure motif; other site
430066004558	NAD binding pocket [chemical binding]; other site
430066004559	Iron/manganese superoxide dismutases, C-terminal domain; Region: Sod_Fe_C; pfam02777
430066004560	carboxynorspermidine decarboxylase; Region: nspC; TIGR01047
430066004561	Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Carboxynorspermidine Decarboxylase; Region: PLPDE_III_CANSDC; cd06829
430066004562	dimer interface [polypeptide binding]; other site
430066004563	active site
430066004564	pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site
430066004565	catalytic residues [active]
430066004566	substrate binding site [chemical binding]; other site
430066004567	Saccharopine dehydrogenase and related proteins [Amino acid transport and metabolism]; Region: LYS9; COG1748
430066004568	NAD(P) binding domain of amino acid dehydrogenase-like proteins; Region: NAD_bind_amino_acid_DH; cl17226
430066004569	NAD(P) binding pocket [chemical binding]; other site
430066004570	Proline racemase [Amino acid transport and metabolism]; Region: COG3938
430066004571	hydroxyproline-2-epimerase; Provisional; Region: PRK13971
430066004572	Invasion protein B, involved in pathogenesis [General function prediction only]; Region: COG5342
430066004573	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4564
430066004574	Cache domain; Region: Cache_2; pfam08269
430066004575	Histidine kinase; Region: HisKA_3; pfam07730
430066004576	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
430066004577	ATP binding site [chemical binding]; other site
430066004578	Mg2+ binding site [ion binding]; other site
430066004579	G-X-G motif; other site
430066004580	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
430066004581	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
430066004582	active site
430066004583	phosphorylation site [posttranslational modification]
430066004584	intermolecular recognition site; other site
430066004585	dimerization interface [polypeptide binding]; other site
430066004586	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
430066004587	DNA binding residues [nucleotide binding]
430066004588	dimerization interface [polypeptide binding]; other site
430066004589	TRAP-type mannitol/chloroaromatic compound transport system, small permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: FcbT2; COG4665
430066004590	TRAP-type mannitol/chloroaromatic compound transport system, large permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: FcbT3; COG4664
430066004591	DctM-like transporters; Region: DctM; pfam06808
430066004592	TRAP-type C4-dicarboxylate transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: DctP; COG1638
430066004593	Bacterial extracellular solute-binding protein, family 7; Region: SBP_bac_7; cl15441
430066004594	hypothetical protein; Provisional; Region: PRK11171
430066004595	Protein of unknown function (DUF861); Region: Cupin_3; pfam05899
430066004596	Uncharacterized conserved protein, contains double-stranded beta-helix domain [Function unknown]; Region: COG1917
430066004597	putative urate catabolism protein; Region: uraD_N-term-dom; TIGR03212
430066004598	Catalytic domain of bacterial PuuE allantoinases, Schizosaccharomyces pombe chitin deacetylase 1 (SpCDA1), and similar proteins; Region: CE4_PuuE_SpCDA1; cd10977
430066004599	active site
430066004600	catalytic site [active]
430066004601	tetramer interface [polypeptide binding]; other site
430066004602	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3195
430066004603	Transthyretin_like.  This domain is present in the transthyretin-like protein (TLP) family which includes transthyretin (TTR) and a transthyretin-related protein called 5-hydroxyisourate hydrolase (HIUase).  TTR and HIUase are homotetrameric proteins...; Region: Transthyretin_like; cl17222
430066004604	homotetramer interface [polypeptide binding]; other site
430066004605	active site
430066004606	Xanthine dehydrogenase, iron-sulfur cluster and FAD-binding subunit A [Nucleotide transport and metabolism]; Region: XdhA; COG4630
430066004607	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
430066004608	catalytic loop [active]
430066004609	2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_3; pfam13085
430066004610	iron binding site [ion binding]; other site
430066004611	[2Fe-2S] binding domain; Region: Fer2_2; pfam01799
430066004612	CO dehydrogenase flavoprotein C-terminal domain; Region: CO_deh_flav_C; pfam03450
430066004613	Xanthine dehydrogenase, molybdopterin-binding subunit B [Nucleotide transport and metabolism]; Region: XdhB; COG4631
430066004614	Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; smart01008
430066004615	Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738
430066004616	Xanthine dehydrogenase, molybdopterin-binding subunit B [Nucleotide transport and metabolism]; Region: XdhB; COG4631
430066004617	XdhC and CoxI family; Region: XdhC_CoxI; pfam02625
430066004618	xanthine dehydrogenase accessory protein XdhC; Region: xanthine_xdhC; TIGR02964
430066004619	XdhC Rossmann domain; Region: XdhC_C; pfam13478
430066004620	Transcriptional regulator [Transcription]; Region: LysR; COG0583
430066004621	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
430066004622	The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422
430066004623	putative effector binding pocket; other site
430066004624	dimerization interface [polypeptide binding]; other site
430066004625	Predicted membrane protein [Function unknown]; Region: COG3748
430066004626	Protein of unknown function (DUF989); Region: DUF989; pfam06181
430066004627	Cytochrome c; Region: Cytochrom_C; pfam00034
430066004628	guanine deaminase; Provisional; Region: PRK09228
430066004629	Guanine deaminase (GDEase). Guanine deaminase is an aminohydrolase responsible for the conversion of guanine to xanthine and ammonia, the first step to utilize guanine as a nitrogen source. This reaction also removes the guanine base from the pool and...; Region: GDEase; cd01303
430066004630	active site
430066004631	Putative glycerate kinase [Carbohydrate transport and metabolism]; Region: GckA; COG2379
430066004632	Domain of unknown function (DUF4147); Region: DUF4147; pfam13660
430066004633	MOFRL family; Region: MOFRL; pfam05161
430066004634	Cytochrome oxidase maturation protein cbb3-type; Region: CcoS; pfam03597
430066004635	Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217
430066004636	Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371
430066004637	metal-binding site [ion binding]
430066004638	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
430066004639	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
430066004640	motif II; other site
430066004641	Predicted integral membrane protein linked to a cation pump [Inorganic ion transport and metabolism]; Region: COG5456
430066004642	FixH; Region: FixH; pfam05751
430066004643	cytochrome c oxidase accessory protein FixG; Region: ccoG_rdxA_fixG; TIGR02745
430066004644	4Fe-4S binding domain; Region: Fer4_5; pfam12801
430066004645	Ubp3 associated protein Bre5; Region: Bre5; pfam11614
430066004646	cytochrome c oxidase, cbb3-type, subunit III; Region: ccoP; TIGR00782
430066004647	Cytochrome c; Region: Cytochrom_C; pfam00034
430066004648	Cytochrome C oxidase, cbb3-type, subunit III; Region: Cytochrome_CBB3; pfam13442
430066004649	Cytochrome cbb oxidase CcoQ.  Cytochrome cbb3 oxidase, the terminal oxidase in the respiratory chains of proteobacteria, is a multi-chain transmembrane protein located in the cell membrane. Like other cytochrome oxidases, it catalyzes the reduction of O2...; Region: cbb3_Oxidase_CcoQ; cd01324
430066004650	Cbb3-type cytochrome oxidase, cytochrome c subunit [Energy production and conversion]; Region: CcoO; COG2993
430066004651	Cytochrome C oxidase, mono-heme subunit/FixO; Region: FixO; pfam02433
430066004652	Cytochrome cbb3 oxidase subunit I.  Cytochrome cbb3 oxidase, the terminal oxidase in the respiratory chains of proteobacteria, is a multi-chain transmembrane protein located in the cell membrane. Like other cytochrome oxidases, it catalyzes the reduction...; Region: cbb3_Oxidase_I; cd01661
430066004653	Low-spin heme binding site [chemical binding]; other site
430066004654	Cytochrome C and Quinol oxidase polypeptide I; Region: COX1; pfam00115
430066004655	Putative water exit pathway; other site
430066004656	Binuclear center (active site) [active]
430066004657	Putative proton exit pathway; other site
430066004658	Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153
430066004659	metal binding site 2 [ion binding]; metal-binding site
430066004660	putative DNA binding helix; other site
430066004661	metal binding site 1 [ion binding]; metal-binding site
430066004662	dimer interface [polypeptide binding]; other site
430066004663	DsbA family, Com1-like subfamily; composed of proteins similar to Com1, a 27-kDa outer membrane-associated immunoreactive protein originally found in both acute and chronic disease strains of the pathogenic bacteria Coxiella burnetti. It contains a CXXC...; Region: DsbA_Com1_like; cd03023
430066004664	DSBA-like thioredoxin domain; Region: DSBA; pfam01323
430066004665	catalytic residues [active]
430066004666	Salicylaldehyde dehydrogenase, DoxF-like; Region: ALDH_SaliADH; cd07105
430066004667	Aldehyde dehydrogenase family; Region: Aldedh; pfam00171
430066004668	NAD(P) binding site [chemical binding]; other site
430066004669	catalytic residues [active]
430066004670	bifunctional DNA-binding transcriptional dual regulator/O6-methylguanine-DNA methyltransferase; Provisional; Region: PRK15435
430066004671	Metal binding domain of Ada; Region: Ada_Zn_binding; pfam02805
430066004672	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
430066004673	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
430066004674	The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445
430066004675	DNA binding site [nucleotide binding]
430066004676	active site
430066004677	Arsenate Reductase (ArsC) family, Yffb subfamily; Yffb is an uncharacterized bacterial protein encoded by the yffb gene, related to the thioredoxin-fold arsenic reductases, ArsC. The structure of Yffb and the conservation of the catalytic cysteine...; Region: ArsC_Yffb; cd03035
430066004678	ArsC family; Region: ArsC; pfam03960
430066004679	putative catalytic residues [active]
430066004680	Predicted membrane protein [Function unknown]; Region: COG4129
430066004681	Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515
430066004682	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
430066004683	putative substrate translocation pore; other site
430066004684	D-galactonate transporter; Region: 2A0114; TIGR00893
430066004685	microcin B17 transporter; Reviewed; Region: PRK11098
430066004686	Putative catalytic domain of uncharacterized bacterial hypothetical proteins similar to insect chitin deacetylase-like proteins; Region: CE4_CDA_like_3; cd10976
430066004687	NodB motif; other site
430066004688	putative active site [active]
430066004689	putative catalytic site [active]
430066004690	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4649
430066004691	GTP-binding protein Der; Reviewed; Region: PRK00093
430066004692	EngA1 GTPase contains the first domain of EngA; Region: EngA1; cd01894
430066004693	G1 box; other site
430066004694	GTP/Mg2+ binding site [chemical binding]; other site
430066004695	Switch I region; other site
430066004696	G2 box; other site
430066004697	Switch II region; other site
430066004698	G3 box; other site
430066004699	G4 box; other site
430066004700	G5 box; other site
430066004701	EngA2 GTPase contains the second domain of EngA; Region: EngA2; cd01895
430066004702	G1 box; other site
430066004703	GTP/Mg2+ binding site [chemical binding]; other site
430066004704	Switch I region; other site
430066004705	G2 box; other site
430066004706	G3 box; other site
430066004707	Switch II region; other site
430066004708	G4 box; other site
430066004709	G5 box; other site
430066004710	Molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: DnaK; COG0443
430066004711	Escherichia coli YegD, a putative chaperone protein, and related proteins; Region: YegD_like; cd10231
430066004712	nucleotide binding site [chemical binding]; other site
430066004713	putative NEF/HSP70 interaction site [polypeptide binding]; other site
430066004714	SBD interface [polypeptide binding]; other site
430066004715	Cell wall hydrolyses involved in spore germination [Cell envelope biogenesis, outer membrane]; Region: SleB; COG3773
430066004716	Cell Wall Hydrolase; Region: Hydrolase_2; pfam07486
430066004717	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5336
430066004718	F0F1-type ATP synthase, subunit a [Energy production and conversion]; Region: AtpB; COG0356
430066004719	F0F1 ATP synthase subunit A; Validated; Region: PRK05815
430066004720	F0F1 ATP synthase subunit C; Validated; Region: PRK07558
430066004721	F0F1 ATP synthase subunit B'; Validated; Region: PRK09174
430066004722	F0F1-type ATP synthase, subunit b [Energy production and conversion]; Region: AtpF; COG0711
430066004723	F0F1 ATP synthase subunit B; Validated; Region: PRK09173
430066004724	F0F1-type ATP synthase, subunit b [Energy production and conversion]; Region: AtpF; COG0711
430066004725	bacterial Ribonuclease HII-like; Region: RNase_HII_bacteria_HII_like; cd07182
430066004726	RNA/DNA hybrid binding site [nucleotide binding]; other site
430066004727	active site
430066004728	DNA repair photolyase [DNA replication, recombination, and repair]; Region: SplB; COG1533
430066004729	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
430066004730	FeS/SAM binding site; other site
430066004731	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
430066004732	active site
430066004733	4-diphosphocytidyl-2-C-methyl-D-erythritol kinase; Provisional; Region: PRK14608
430066004734	GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544
430066004735	pH-dependent sodium/proton antiporter; Reviewed; Region: nhaA; PRK09560
430066004736	Signal peptide peptidase A (SppA), a serine protease, has catalytic Ser-Lys dyad; Region: S49_Sppa_N_C; cd07023
430066004737	signal peptide peptidase SppA, 36K type; Region: SppA_dom; TIGR00706
430066004738	tandem repeat interface [polypeptide binding]; other site
430066004739	oligomer interface [polypeptide binding]; other site
430066004740	active site residues [active]
430066004741	Predicted O-methyltransferase [General function prediction only]; Region: COG4123
430066004742	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
430066004743	Domain of unknown function (DUF2007); Region: DUF2007; pfam09413
430066004744	Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142
430066004745	Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685
430066004746	substrate binding pocket [chemical binding]; other site
430066004747	chain length determination region; other site
430066004748	substrate-Mg2+ binding site; other site
430066004749	catalytic residues [active]
430066004750	aspartate-rich region 1; other site
430066004751	active site lid residues [active]
430066004752	aspartate-rich region 2; other site
430066004753	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
430066004754	binding surface
430066004755	TPR motif; other site
430066004756	TPR repeat; Region: TPR_11; pfam13414
430066004757	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
430066004758	binding surface
430066004759	TPR motif; other site
430066004760	TPR repeat; Region: TPR_11; pfam13414
430066004761	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
430066004762	binding surface
430066004763	TPR motif; other site
430066004764	TPR repeat; Region: TPR_11; pfam13414
430066004765	Class II Glycyl-tRNA synthetase (GlyRS) alpha subunit core catalytic domain. GlyRS functions as a homodimer in eukaryotes, archaea and some bacteria and as a heterotetramer in the remainder of prokaryotes and in arabidopsis. It is responsible for the...; Region: GlyRS_alpha_core; cd00733
430066004766	dimer interface [polypeptide binding]; other site
430066004767	motif 1; other site
430066004768	active site
430066004769	motif 2; other site
430066004770	motif 3; other site
430066004771	glycyl-tRNA synthetase subunit beta; Validated; Region: glyS; PRK01233
430066004772	glycyl-tRNA synthetase subunit beta; Validated; Region: glyS; PRK01233
430066004773	DALR anticodon binding domain; Region: DALR_1; pfam05746
430066004774	Putative translation factor (SUA5) [Translation, ribosomal structure and biogenesis]; Region: SUA5; COG0009
430066004775	Putative GTP-binding controlling metal-binding; Region: SUA5; pfam03481
430066004776	FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277
430066004777	FAD binding domain; Region: FAD_binding_4; pfam01565
430066004778	Plasmid stabilization system protein [General function prediction only]; Region: ParE; COG3668
430066004779	Predicted transcriptional regulator [Transcription]; Region: COG3905
430066004780	enoyl-CoA hydratase; Provisional; Region: PRK06688
430066004781	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
430066004782	substrate binding site [chemical binding]; other site
430066004783	oxyanion hole (OAH) forming residues; other site
430066004784	trimer interface [polypeptide binding]; other site
430066004785	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
430066004786	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
430066004787	active site
430066004788	Acetyl-CoA dehydrogenase C-terminal like; Region: Acyl-CoA_dh_C; pfam12806
430066004789	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
430066004790	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
430066004791	metal binding site [ion binding]; metal-binding site
430066004792	active site
430066004793	I-site; other site
430066004794	phosphoribosylamine--glycine ligase; Provisional; Region: PRK00885
430066004795	Phosphoribosylglycinamide synthetase, N domain; Region: GARS_N; pfam02844
430066004796	Phosphoribosylglycinamide synthetase, ATP-grasp (A) domain; Region: GARS_A; pfam01071
430066004797	Phosphoribosylglycinamide synthetase, C domain; Region: GARS_C; pfam02843
430066004798	4-hydroxybenzoate polyprenyltransferase; Reviewed; Region: ubiA; PRK12878
430066004799	UbiA prenyltransferase family; Region: UbiA; pfam01040
430066004800	pyridoxamine 5'-phosphate oxidase; Provisional; Region: PRK05679
430066004801	Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_oxidase; pfam01243
430066004802	Pyridoxine 5'-phosphate oxidase C-terminal dimerisation region; Region: PNPOx_C; pfam10590
430066004803	chaperone protein DnaJ; Provisional; Region: PRK14299
430066004804	DnaJ domain or J-domain.  DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257
430066004805	HSP70 interaction site [polypeptide binding]; other site
430066004806	C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747
430066004807	dimer interface [polypeptide binding]; other site
430066004808	enoyl-(acyl carrier protein) reductase; Provisional; Region: PRK08159
430066004809	Enoyl acyl carrier protein (ACP) reductase (ENR), divergent SDR; Region: ENR_SDR; cd05372
430066004810	NAD binding site [chemical binding]; other site
430066004811	homotetramer interface [polypeptide binding]; other site
430066004812	homodimer interface [polypeptide binding]; other site
430066004813	substrate binding site [chemical binding]; other site
430066004814	active site
430066004815	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
430066004816	catalytic core [active]
430066004817	Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea.  CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458
430066004818	DNA-binding site [nucleotide binding]; DNA binding site
430066004819	RNA-binding motif; other site
430066004820	Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: DUF374; Region: LPLAT_DUF374-like; cd07983
430066004821	putative acyl-acceptor binding pocket; other site
430066004822	Protein of unknown function (DUF1344); Region: DUF1344; pfam07076
430066004823	Chorismate synthase [Amino acid transport and metabolism]; Region: AroC; COG0082
430066004824	Chorismase synthase, the enzyme catalyzing the final step of the shikimate pathway; Region: Chorismate_synthase; cd07304
430066004825	Tetramer interface [polypeptide binding]; other site
430066004826	active site
430066004827	FMN-binding site [chemical binding]; other site
430066004828	bifunctional 3,4-dihydroxy-2-butanone 4-phosphate synthase/GTP cyclohydrolase II protein; Provisional; Region: PRK09314
430066004829	3,4-dihydroxy-2-butanone 4-phosphate synthase; Region: DHBP_synthase; pfam00926
430066004830	GTP cyclohydrolase II [Coenzyme metabolism]; Region: RibA; COG0807
430066004831	dimerization interface [polypeptide binding]; other site
430066004832	active site
430066004833	Deacetylases, including yeast histone deacetylase and acetoin utilization protein [Chromatin structure and dynamics / Secondary metabolites biosynthesis, transport, and catabolism]; Region: AcuC; COG0123
430066004834	Histone deacetylases and histone-like deacetylases, classII; Region: HDAC_classII_2; cd11599
430066004835	putative active site [active]
430066004836	Zn binding site [ion binding]; other site
430066004837	exodeoxyribonuclease VII small subunit; Provisional; Region: PRK00977
430066004838	Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586
430066004839	SNARE associated Golgi protein; Region: SNARE_assoc; cl00429
430066004840	Predicted membrane protein [Function unknown]; Region: COG2261
430066004841	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3753
430066004842	Pirin-related protein [General function prediction only]; Region: COG1741
430066004843	Pirin; Region: Pirin; pfam02678
430066004844	Pirin C-terminal cupin domain; Region: Pirin_C; pfam05726
430066004845	1-deoxy-D-xylulose-5-phosphate synthase; Provisional; Region: PRK05444
430066004846	Thiamine pyrophosphate (TPP) family, DXS subfamily, TPP-binding module; 1-Deoxy-D-xylulose-5-phosphate synthase (DXS) is a regulatory enzyme of the mevalonate-independent pathway involved in terpenoid biosynthesis. Terpeniods are plant natural products...; Region: TPP_DXS; cd02007
430066004847	TPP-binding site; other site
430066004848	Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033
430066004849	PYR/PP interface [polypeptide binding]; other site
430066004850	dimer interface [polypeptide binding]; other site
430066004851	TPP binding site [chemical binding]; other site
430066004852	Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780
430066004853	Predicted rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: COG1189
430066004854	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
430066004855	RNA binding surface [nucleotide binding]; other site
430066004856	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
430066004857	S-adenosylmethionine binding site [chemical binding]; other site
430066004858	SAM-dependent methyltransferases related to tRNA (uracil-5-)-methyltransferase [Translation, ribosomal structure and biogenesis]; Region: TrmA; COG2265
430066004859	Methyltransferase domain; Region: Methyltransf_26; pfam13659
430066004860	Predicted Rossmann fold nucleotide-binding protein [General function prediction only]; Region: COG1611
430066004861	Predicted periplasmic protein [General function prediction only]; Region: COG3895
430066004862	Membrane-bound lysozyme-inhibitor of c-type lysozyme; Region: MliC; pfam09864
430066004863	Uncharacterized protein containing LysM domain [Function unknown]; Region: XkdP; COG1652
430066004864	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
430066004865	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
430066004866	ABC-type transport system involved in Fe-S cluster assembly, permease and ATPase components [Posttranslational modification, protein turnover, chaperones]; Region: ATM1; COG5265
430066004867	ATP-binding cassette domain of iron-sulfur clusters transporter, subfamily C; Region: ABCC_ATM1_transporter; cd03253
430066004868	Walker A/P-loop; other site
430066004869	ATP binding site [chemical binding]; other site
430066004870	Q-loop/lid; other site
430066004871	ABC transporter signature motif; other site
430066004872	Walker B; other site
430066004873	D-loop; other site
430066004874	H-loop/switch region; other site
430066004875	phosphatidylserine decarboxylase; Provisional; Region: PRK05305
430066004876	Phosphatidylserine synthase [Lipid metabolism]; Region: PssA; COG1183
430066004877	CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; pfam01066
430066004878	putative oxoacyl-(acyl carrier protein) reductase; Provisional; Region: PRK08945
430066004879	classical (c) SDRs; Region: SDR_c; cd05233
430066004880	NAD(P) binding site [chemical binding]; other site
430066004881	active site
430066004882	amidophosphoribosyltransferase; Provisional; Region: PRK09123
430066004883	Glutamine amidotransferases class-II (GN-AT)_GPAT- type. This domain is found at the N-terminus of  glutamine phosphoribosylpyrophosphate (Prpp) amidotransferase (GPATase) . The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the...; Region: GPATase_N; cd00715
430066004884	active site
430066004885	tetramer interface [polypeptide binding]; other site
430066004886	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
430066004887	active site
430066004888	Uncharacterized membrane protein, required for colicin V production [General function prediction only]; Region: CvpA; COG1286
430066004889	Colicin V production protein; Region: Colicin_V; pfam02674
430066004890	DNA repair protein RadA; Provisional; Region: PRK11823
430066004891	Sms (bacterial radA) DNA repair protein. This protein is not related to archael radA any more than is to other RecA-like NTPases. Sms has a role in recombination and recombinational repair and is responsible for the stabilization or processing of...; Region: Sms; cd01121
430066004892	Walker A motif/ATP binding site; other site
430066004893	ATP binding site [chemical binding]; other site
430066004894	Walker B motif; other site
430066004895	Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541
430066004896	replicative DNA helicase; Provisional; Region: PRK09165
430066004897	DnaB-like helicase N terminal domain; Region: DnaB; pfam00772
430066004898	DnaB helicase C terminal domain. The hexameric helicase DnaB unwinds the DNA duplex at the  chromosome replication fork. Although the mechanism by which DnaB both couples ATP hydrolysis to translocation along DNA and denatures the duplex is unknown, a...; Region: DnaB_C; cd00984
430066004899	Walker A motif; other site
430066004900	ATP binding site [chemical binding]; other site
430066004901	Walker B motif; other site
430066004902	DNA binding loops [nucleotide binding]
430066004903	Cyclopropane fatty acid synthase and related methyltransferases [Cell envelope biogenesis, outer membrane]; Region: Cfa; COG2230
430066004904	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
430066004905	S-adenosylmethionine binding site [chemical binding]; other site
430066004906	50S ribosomal protein L9; Reviewed; Region: rplI; PRK00137
430066004907	Ribosomal protein L9, N-terminal domain; Region: Ribosomal_L9_N; pfam01281
430066004908	Ribosomal protein L9, C-terminal domain; Region: Ribosomal_L9_C; pfam03948
430066004909	30S ribosomal protein S18; Reviewed; Region: rpsR; PRK00391
430066004910	30S ribosomal protein S6; Reviewed; Region: rpsF; PRK00453
430066004911	(acyl-carrier-protein) S-malonyltransferase [Lipid metabolism]; Region: FabD; COG0331
430066004912	malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128
430066004913	3-ketoacyl-(acyl-carrier-protein) reductase NodG; Reviewed; Region: PRK12936
430066004914	beta-Keto acyl carrier protein reductase (BKR), involved in Type II FAS, classical (c) SDRs; Region: BKR_SDR_c; cd05333
430066004915	NAD(P) binding site [chemical binding]; other site
430066004916	homotetramer interface [polypeptide binding]; other site
430066004917	homodimer interface [polypeptide binding]; other site
430066004918	active site
430066004919	acyl carrier protein; Provisional; Region: acpP; PRK00982
430066004920	3-oxoacyl-(acyl carrier protein) synthase II; Reviewed; Region: PRK07314
430066004921	Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834
430066004922	dimer interface [polypeptide binding]; other site
430066004923	active site
430066004924	Aminodeoxychorismate lyase [Coenzyme transport and metabolism]; Region: COG1559
430066004925	proteins similar to Escherichia coli yceG; Region: yceG_like; cd08010
430066004926	dimerization interface [polypeptide binding]; other site
430066004927	Uncharacterized stress-induced protein [Function unknown]; Region: COG1561
430066004928	YicC-like family, N-terminal region; Region: YicC_N; pfam03755
430066004929	Domain of unknown function (DUF1732); Region: DUF1732; pfam08340
430066004930	Guanylate kinase [Nucleotide transport and metabolism]; Region: Gmk; COG0194
430066004931	Guanosine monophosphate kinase (GMPK, EC 2.7.4.8), also known as guanylate kinase (GKase), catalyzes the reversible phosphoryl transfer from adenosine triphosphate (ATP) to guanosine monophosphate (GMP) to yield adenosine diphosphate (ADP) and guanosine...; Region: GMPK; cd00071
430066004932	catalytic site [active]
430066004933	G-X2-G-X-G-K; other site
430066004934	protease TldD; Provisional; Region: tldD; PRK10735
430066004935	Invasion protein B, involved in pathogenesis [General function prediction only]; Region: COG5342
430066004936	Heme/copper-type cytochrome/quinol oxidases, subunit 2 [Energy production and conversion]; Region: CyoA; COG1622
430066004937	Cytochrome C oxidase subunit II, transmembrane domain; Region: COX2_TM; pfam02790
430066004938	Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; pfam00116
430066004939	Heme/copper-type cytochrome/quinol oxidases, subunit 1 [Energy production and conversion]; Region: CyoB; COG0843
430066004940	Cytochrome C oxidase subunit I.  Cytochrome c oxidase (CcO), the terminal oxidase in the respiratory chains of eukaryotes and most bacteria, is a multi-chain transmembrane protein located in the inner membrane of mitochondria and the cell membrane of...; Region: Cyt_c_Oxidase_I; cd01663
430066004941	Subunit I/III interface [polypeptide binding]; other site
430066004942	D-pathway; other site
430066004943	Subunit I/VIIc interface [polypeptide binding]; other site
430066004944	Subunit I/IV interface [polypeptide binding]; other site
430066004945	Subunit I/II interface [polypeptide binding]; other site
430066004946	Low-spin heme (heme a) binding site [chemical binding]; other site
430066004947	Subunit I/VIIa interface [polypeptide binding]; other site
430066004948	Subunit I/VIa interface [polypeptide binding]; other site
430066004949	Dimer interface; other site
430066004950	Putative water exit pathway; other site
430066004951	Binuclear center (heme a3/CuB) [ion binding]; other site
430066004952	K-pathway; other site
430066004953	Subunit I/Vb interface [polypeptide binding]; other site
430066004954	Putative proton exit pathway; other site
430066004955	Subunit I/VIb interface; other site
430066004956	Subunit I/VIc interface [polypeptide binding]; other site
430066004957	Electron transfer pathway; other site
430066004958	Subunit I/VIIIb interface [polypeptide binding]; other site
430066004959	Subunit I/VIIb interface [polypeptide binding]; other site
430066004960	protoheme IX farnesyltransferase; Provisional; Region: PRK04375
430066004961	UbiA prenyltransferase family; Region: UbiA; pfam01040
430066004962	Cytochrome c oxidase subunit III.  Cytochrome c oxidase (CcO), the terminal oxidase in the respiratory chains of eukaryotes and most bacteria, is a multi-chain transmembrane protein located in the inner membrane of mitochondria and the cell membrane of...; Region: Cyt_c_Oxidase_III; cd01665
430066004963	Subunit III/VIIa interface [polypeptide binding]; other site
430066004964	Phospholipid binding site [chemical binding]; other site
430066004965	Subunit I/III interface [polypeptide binding]; other site
430066004966	Subunit III/VIb interface [polypeptide binding]; other site
430066004967	Subunit III/VIa interface; other site
430066004968	Subunit III/Vb interface [polypeptide binding]; other site
430066004969	SURF1 superfamily. Surf1/Shy1 has been implicated in the posttranslational steps of the biogenesis of the mitochondrially-encoded Cox1 subunit of cytochrome c oxidase (complex IV). Cytochrome c oxidase (complex IV), the terminal electron-transferring...; Region: SURF1; cd06662
430066004970	4-Hydroxy-3-methylbut-2-enyl diphosphate reductase IspH [Lipid metabolism]; Region: lytB; COG0761
430066004971	4-hydroxy-3-methylbut-2-enyl diphosphate reductase; Reviewed; Region: ispH; PRK01045
430066004972	Putative homoserine kinase type II (protein kinase fold) [General function prediction only]; Region: COG2334
430066004973	Homoserine Kinase, type II. Homoserine kinase is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs), RIO kinases, actin-fragmin kinase (AFK), and...; Region: HomoserineK_II; cd05153
430066004974	putative active site [active]
430066004975	putative substrate binding site [chemical binding]; other site
430066004976	ATP binding site [chemical binding]; other site
430066004977	RNase HI family found mainly in prokaryotes; Region: RNase_HI_prokaryote_like; cd09278
430066004978	RNA/DNA hybrid binding site [nucleotide binding]; other site
430066004979	active site
430066004980	Peroxiredoxin (PRX) family, PRX5-like subfamily; members are similar to the human protein, PRX5, a homodimeric TRX peroxidase, widely expressed in tissues and found cellularly in mitochondria, peroxisomes and the cytosol. The cellular location of PRX5...; Region: PRX5_like; cd03013
430066004981	catalytic triad [active]
430066004982	dimer interface [polypeptide binding]; other site
430066004983	Uncharacterized protein predicted to be involved in C-type cytochrome biogenesis [Posttranslational modification, protein turnover, chaperones / Energy production and conversion]; Region: COG4233
430066004984	hypothetical protein; Validated; Region: PRK00228
430066004985	7TMR-DISM extracellular 2; Region: 7TMR-DISMED2; pfam07696
430066004986	PAS fold; Region: PAS_3; pfam08447
430066004987	Motif C-terminal to PAS motifs (likely to contribute to PAS structural domain); Region: PAC; smart00086
430066004988	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
430066004989	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
430066004990	metal binding site [ion binding]; metal-binding site
430066004991	active site
430066004992	I-site; other site
430066004993	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
430066004994	Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302
430066004995	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182
430066004996	Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612
430066004997	Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675
430066004998	Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193
430066004999	Threonine synthase [Amino acid transport and metabolism]; Region: ThrC; COG0498
430066005000	Threonine synthase catalyzes the final step of threonine biosynthesis. The conversion of O-phosphohomoserine into threonine and inorganic phosphate is pyridoxal 5'-phosphate dependent. The Thr-synth_1 CD includes members from higher plants; Region: Thr-synth_2; cd01560
430066005001	pyridoxal 5'-phosphate binding site [chemical binding]; other site
430066005002	catalytic residue [active]
430066005003	Predicted signal transduction protein containing sensor and EAL domains [Signal transduction mechanisms]; Region: COG4943
430066005004	CSS motif domain associated with EAL; Region: CSS-motif; pfam12792
430066005005	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
430066005006	Predicted phosphatase/phosphohexomutase [General function prediction only]; Region: COG0637
430066005007	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
430066005008	active site
430066005009	motif I; other site
430066005010	motif II; other site
430066005011	CLC voltage-gated chloride channel. The ClC chloride channels catalyse the selective flow of Cl- ions across cell membranes, thereby regulating electrical excitation in skeletal muscle and the flow of salt and water across epithelial barriers. This...; Region: Voltage_gated_ClC; cd00400
430066005012	Chloride channel protein EriC [Inorganic ion transport and metabolism]; Region: EriC; COG0038
430066005013	Cl- selectivity filter; other site
430066005014	Cl- binding residues [ion binding]; other site
430066005015	pore gating glutamate residue; other site
430066005016	dimer interface [polypeptide binding]; other site
430066005017	The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354
430066005018	DNA modification methylase [DNA replication, recombination, and repair]; Region: COG0863
430066005019	DNA methylase; Region: N6_N4_Mtase; pfam01555
430066005020	Haloacid dehalogenase-like hydrolase; Region: HAD_2; pfam13419
430066005021	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
430066005022	motif II; other site
430066005023	A/G-specific DNA glycosylase [DNA replication, recombination, and repair]; Region: MutY; COG1194
430066005024	endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056
430066005025	minor groove reading motif; other site
430066005026	helix-hairpin-helix signature motif; other site
430066005027	substrate binding pocket [chemical binding]; other site
430066005028	active site
430066005029	iron-sulpphur binding domain in DNA-(apurinic or apyrimidinic site) lyase (subfamily of ENDO3); Region: FES; smart00525
430066005030	DNA glycosylase (MutY in bacteria and hMYH in humans) is responsible for repairing misread  A*oxoG residues to C*G by removing the inappropriately paired adenine base from the DNA backbone. It belongs to the Nudix hydrolase superfamily and is important...; Region: DNA_Glycosylase_C; cd03431
430066005031	DNA binding and oxoG recognition site [nucleotide binding]
430066005032	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5389
430066005033	DSBA-like thioredoxin domain; Region: DSBA; pfam01323
430066005034	DsbA family; consists of DsbA and DsbA-like proteins, including DsbC, DsbG, glutathione (GSH) S-transferase kappa (GSTK), 2-hydroxychromene-2-carboxylate (HCCA) isomerase, an oxidoreductase (FrnE) presumed to be involved in frenolicin biosynthesis, a...; Region: DsbA_family; cd02972
430066005035	catalytic residues [active]
430066005036	Chromosome segregation ATPases [Cell division and chromosome partitioning]; Region: Smc; COG1196
430066005037	ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278
430066005038	Walker A/P-loop; other site
430066005039	ATP binding site [chemical binding]; other site
430066005040	ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278
430066005041	ABC transporter signature motif; other site
430066005042	Walker B; other site
430066005043	D-loop; other site
430066005044	H-loop/switch region; other site
430066005045	Co/Zn/Cd efflux system component [Inorganic ion transport and metabolism]; Region: CzcD; COG1230
430066005046	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
430066005047	N-terminal domain of Streptomyces griseus SgaA (suppression of growth disturbance caused by A-factor at a high concentration under high osmolality during early growth phase), and similar domains; Region: SgaA_N_like; cd07247
430066005048	pyruvate phosphate dikinase; Provisional; Region: PRK09279
430066005049	Pyruvate phosphate dikinase, PEP/pyruvate binding domain; Region: PPDK_N; pfam01326
430066005050	PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391
430066005051	PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896
430066005052	Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726
430066005053	Putative catalytic NodB homology domain of uncharacterized BH0857 protein from Bacillus halodurans and its bacterial homologs; Region: CE4_BH0857_like; cd10955
430066005054	NodB motif; other site
430066005055	putative active site [active]
430066005056	putative catalytic site [active]
430066005057	Protein of unknown function (DUF1499); Region: DUF1499; pfam07386
430066005058	Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491
430066005059	Uncharacterized conserved protein [General function prediction only]; Region: BioY; COG1268
430066005060	Ureidoglycolate hydrolase [Nucleotide transport and metabolism]; Region: DAL3; COG3194
430066005061	ureidoglycolate hydrolase; Provisional; Region: PRK03606
430066005062	HIUase (5-hydroxyisourate hydrolase) catalyzes the second step in a three-step ureide pathway in which 5-hydroxyisourate (HIU), a product of the uricase (urate oxidase) reaction, is hydrolyzed to 2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline (OHCU); Region: TLP_HIUase; cd05822
430066005063	active site
430066005064	homotetramer interface [polypeptide binding]; other site
430066005065	Protein of unknown function (DUF2793); Region: DUF2793; pfam10983
430066005066	Predicted nucleoside-diphosphate sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG1086
430066005067	UDP-Glcnac (UDP-linked N-acetylglucosamine) inverting 4,6-dehydratase, extended (e) SDRs; Region: UDP_invert_4-6DH_SDR_e; cd05237
430066005068	NAD(P) binding site [chemical binding]; other site
430066005069	homodimer interface [polypeptide binding]; other site
430066005070	substrate binding site [chemical binding]; other site
430066005071	active site
430066005072	UDP-N-acetylmuramyl pentapeptide phosphotransferase/UDP-N- acetylglucosamine-1-phosphate transferase [Cell envelope biogenesis, outer membrane]; Region: Rfe; COG0472
430066005073	The members of this subfamily catalyze the formation of a phosphodiester bond between a membrane-associated undecaprenyl-phosphate (Und-P) molecule and N-acetylhexosamine 1-phosphate, which is usually donated by a soluble UDP-N-acetylhexosamine precursor; Region: GT_WbpL_WbcO_like; cd06854
430066005074	Mg++ binding site [ion binding]; other site
430066005075	putative catalytic motif [active]
430066005076	putative substrate binding site [chemical binding]; other site
430066005077	Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340
430066005078	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
430066005079	Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586
430066005080	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: Tra5; COG2801
430066005081	Integrase core domain; Region: rve; pfam00665
430066005082	Methionyl-tRNA formyltransferase [Translation, ribosomal structure and biogenesis]; Region: Fmt; COG0223
430066005083	Formyltransferase, catalytic core domain; Region: FMT_core; cd08369
430066005084	active site
430066005085	substrate binding site [chemical binding]; other site
430066005086	cosubstrate binding site; other site
430066005087	catalytic site [active]
430066005088	ABC-type polysaccharide/polyol phosphate transport system, ATPase component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagH; COG1134
430066005089	ATP-binding cassette component of polysaccharide transport system; Region: ABC_KpsT_Wzt; cd03220
430066005090	Walker A/P-loop; other site
430066005091	ATP binding site [chemical binding]; other site
430066005092	Q-loop/lid; other site
430066005093	ABC transporter signature motif; other site
430066005094	Walker B; other site
430066005095	D-loop; other site
430066005096	H-loop/switch region; other site
430066005097	ABC-type polysaccharide/polyol phosphate export systems, permease component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagG; COG1682
430066005098	ABC-2 type transporter; Region: ABC2_membrane; pfam01061
430066005099	Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WecE; COG0399
430066005100	3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616
430066005101	inhibitor-cofactor binding pocket; inhibition site
430066005102	pyridoxal 5'-phosphate binding site [chemical binding]; other site
430066005103	catalytic residue [active]
430066005104	GDP-D-mannose dehydratase [Cell envelope biogenesis, outer membrane]; Region: Gmd; COG1089
430066005105	GDP-mannose 4,6 dehydratase, extended (e) SDRs; Region: GDP_MD_SDR_e; cd05260
430066005106	NADP-binding site; other site
430066005107	homotetramer interface [polypeptide binding]; other site
430066005108	substrate binding site [chemical binding]; other site
430066005109	homodimer interface [polypeptide binding]; other site
430066005110	active site
430066005111	Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340
430066005112	Integrase core domain; Region: rve; pfam00665
430066005113	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: Tra5; COG2801
430066005114	Integrase core domain; Region: rve_3; pfam13683
430066005115	Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340
430066005116	Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586
430066005117	This family is most closely related to the GT1 family of glycosyltransferases. mtfB (mannosyltransferase B) in E. coli has been shown to direct the growth of the O9-specific polysaccharide chain. It transfers two mannoses into the position 3 of the...; Region: GT1_mtfB_like; cd03809
430066005118	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
430066005119	Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340
430066005120	Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586
430066005121	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
430066005122	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3293
430066005123	Integrase core domain; Region: rve_3; cl15866
430066005124	Phosphomannomutase [Carbohydrate transport and metabolism]; Region: {ManB}; COG1109
430066005125	ManB is a bacterial phosphomannomutase (PMM) that catalyzes the conversion of mannose 6-phosphate to mannose-1-phosphate in the second of three steps in the GDP-mannose pathway, in which GDP-D-mannose is synthesized from fructose-6-phosphate. In...; Region: ManB; cd03088
430066005126	active site
430066005127	substrate binding site [chemical binding]; other site
430066005128	metal binding site [ion binding]; metal-binding site
430066005129	GDP-M1P_Guanylyltransferase catalyzes the formation of GDP-Mannose; Region: GDP-M1P_Guanylyltransferase; cd02509
430066005130	mannose-1-phosphate guanylyltransferase/mannose-6-phosphate isomerase; Region: GMP_PMI; TIGR01479
430066005131	Substrate binding site; other site
430066005132	Mannose-6-phosphate isomerase; Region: MannoseP_isomer; pfam01050
430066005133	AGE domain; N-acyl-D-glucosamine 2-epimerase domain; Responsible for intermediate epimerization during biosynthesis of N-acetylneuraminic acid. Catalytic mechanism is believed to be via nucleotide elimination and readdition and is ATP modulated. AGE is...; Region: AGE; cd00249
430066005134	dimerization interface [polypeptide binding]; other site
430066005135	putative active cleft [active]
430066005136	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
430066005137	This family is most closely related to the GT1 family of glycosyltransferases. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can...; Region: GT1_like_4; cd03795
430066005138	putative ADP-binding pocket [chemical binding]; other site
430066005139	D-ribose transporter ATP binding protein; Provisional; Region: PRK10762
430066005140	First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216
430066005141	Q-loop/lid; other site
430066005142	ABC transporter signature motif; other site
430066005143	Walker B; other site
430066005144	D-loop; other site
430066005145	H-loop/switch region; other site
430066005146	Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215
430066005147	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
430066005148	Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579
430066005149	TM-ABC transporter signature motif; other site
430066005150	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: RbsB; COG1879
430066005151	Periplasmic sugar-binding domain of uncharacterized ABC-type transport systems; Region: PBP1_ABC_sugar_binding_like_3; cd06311
430066005152	putative ligand binding site [chemical binding]; other site
430066005153	Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082
430066005154	AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cl12060
430066005155	Metal-binding active site; metal-binding site
430066005156	AP endonuclease family 2 C terminus; Region: AP_endonuc_2_N; pfam07582
430066005157	Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673
430066005158	Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408
430066005159	Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894
430066005160	xylose isomerase; Provisional; Region: PRK05474
430066005161	xylose isomerase; Region: xylose_isom_A; TIGR02630
430066005162	Escherichia coli xylulokinase-like D-xylulose kinases; a subgroup of the FGGY family of carbohydrate kinases; Region: FGGY_D-XK_EcXK-like; cd07808
430066005163	N- and C-terminal domain interface [polypeptide binding]; other site
430066005164	D-xylulose kinase; Region: XylB; TIGR01312
430066005165	active site
430066005166	MgATP binding site [chemical binding]; other site
430066005167	catalytic site [active]
430066005168	metal binding site [ion binding]; metal-binding site
430066005169	xylulose binding site [chemical binding]; other site
430066005170	homodimer interface [polypeptide binding]; other site
430066005171	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
430066005172	DNA binding site [nucleotide binding]
430066005173	domain linker motif; other site
430066005174	Periplasmic sugar-binding domain of uncharacterized transport systems; Region: PBP1_uncharacterized_sugar_binding; cd06307
430066005175	Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407
430066005176	putative ligand binding site [chemical binding]; other site
430066005177	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
430066005178	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
430066005179	DNA-binding transcriptional activator FeaR; Provisional; Region: PRK09685
430066005180	betaine aldehyde dehydrogenase; Provisional; Region: PRK13252
430066005181	NAD+-dependent 4-trimethylaminobutyraldehyde dehydrogenase, ALDH family 9A1; Region: ALDH_F9_TMBADH; cd07090
430066005182	tetrameric interface [polypeptide binding]; other site
430066005183	NAD binding site [chemical binding]; other site
430066005184	catalytic residues [active]
430066005185	choline dehydrogenase; Validated; Region: PRK02106
430066005186	GMC oxidoreductase; Region: GMC_oxred_C; pfam05199
430066005187	transcriptional regulator BetI; Validated; Region: PRK00767
430066005188	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
430066005189	Bacterial transcriptional repressor; Region: TetR_C_6; pfam13977
430066005190	L-asparaginase II [Amino acid transport and metabolism]; Region: AnsA; COG4448
430066005191	transcription elongation factor regulatory protein; Validated; Region: PRK06342
430066005192	Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272
430066005193	Prophage maintenance system killer protein [General function prediction only]; Region: Doc; COG3654
430066005194	putative addiction module antidote; Region: doc_partner; TIGR02609
430066005195	Mg2+ and Co2+ transporters [Inorganic ion transport and metabolism]; Region: CorA; COG0598
430066005196	uncharacterized subgroup of the Escherichia coli Mg2+ transporter CorA_like subfamily; Region: EcCorA-like_u1; cd12837
430066005197	Cl binding site [ion binding]; other site
430066005198	oligomer interface [polypeptide binding]; other site
430066005199	Cyanate permease [Inorganic ion transport and metabolism]; Region: CynX; COG2807
430066005200	Bacterial protein of unknown function (DUF853); Region: DUF853; pfam05872
430066005201	FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580
430066005202	Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376
430066005203	L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734
430066005204	2-haloalkanoic acid dehalogenase, type II; Region: HAD_type_II; TIGR01428
430066005205	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
430066005206	motif II; other site
430066005207	Superoxide dismutase [Inorganic ion transport and metabolism]; Region: SodA; COG0605
430066005208	Iron/manganese superoxide dismutases, alpha-hairpin domain; Region: Sod_Fe_N; pfam00081
430066005209	Iron/manganese superoxide dismutases, C-terminal domain; Region: Sod_Fe_C; pfam02777
430066005210	Protease II [Amino acid transport and metabolism]; Region: PtrB; COG1770
430066005211	Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326
430066005212	Predicted transcriptional regulator [Transcription]; Region: COG4957
430066005213	ATPase involved in DNA replication initiation [DNA replication, recombination, and repair]; Region: DnaA; COG0593
430066005214	C-terminal domain of bacterial DnaA proteins. The DNA-binding C-terminal domain of DnaA contains a helix-turn-helix motif that specifically interacts with the DnaA box, a 9-mer motif that occurs repetitively in the replication origin oriC. Multiple...; Region: Bac_DnaA_C; cd06571
430066005215	DnaA box-binding interface [nucleotide binding]; other site
430066005216	amidase; Validated; Region: PRK05962
430066005217	amidase; Provisional; Region: PRK07056
430066005218	Cysteine desulfurase SufE subunit [Posttranslational modification, protein turnover, chaperones]; Region: sufE; COG2166
430066005219	Flavin Reductases; Region: FlaRed; cl00801
430066005220	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459
430066005221	putative active site [active]
430066005222	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
430066005223	heme pocket [chemical binding]; other site
430066005224	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
430066005225	dimer interface [polypeptide binding]; other site
430066005226	phosphorylation site [posttranslational modification]
430066005227	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
430066005228	ATP binding site [chemical binding]; other site
430066005229	Mg2+ binding site [ion binding]; other site
430066005230	G-X-G motif; other site
430066005231	Putative peptidoglycan-binding domain-containing protein [Cell envelope biogenesis, outer membrane]; Region: COG3409
430066005232	Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471
430066005233	Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471
430066005234	Uncharacterized conserved protein [Function unknown]; Region: COG5447
430066005235	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5330
430066005236	Uncharacterized protein conserved in bacteria (DUF2336); Region: DUF2336; pfam10098
430066005237	Predicted integral membrane protein [Function unknown]; Region: COG5436
430066005238	Uncharacterized conserved protein [Function unknown]; Region: COG5402
430066005239	Transglycosylase; Region: Transgly; pfam00912
430066005240	penicillin-binding protein, 1A family; Region: PBP_1a_fam; TIGR02074
430066005241	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760
430066005242	NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961
430066005243	Uncharacterized conserved protein [Function unknown]; Region: COG5323
430066005244	Terminase-like family; Region: Terminase_6; pfam03237
430066005245	Phage-related protein [Function unknown]; Region: COG4695
430066005246	phage portal protein, HK97 family; Region: portal_HK97; TIGR01537
430066005247	Caudovirus prohead protease; Region: Peptidase_U35; pfam04586
430066005248	Predicted phage phi-C31 gp36 major capsid-like protein [General function prediction only]; Region: COG4653
430066005249	Phage capsid family; Region: Phage_capsid; pfam05065
430066005250	phage conserved hypothetical protein, phiE125 gp8 family; Region: phage_chp_gp8; TIGR02215
430066005251	Head-Tail Connector Protein gp6 of Bacteriophage HK97 and similar proteins; Region: gp6; cd08054
430066005252	Head-Tail Connector Protein gp6 of Bacteriophage HK97 and similar proteins; Region: gp6; cd08054
430066005253	oligomerization interface [polypeptide binding]; other site
430066005254	Phage head-tail joining protein; Region: Phage_H_T_join; pfam05521
430066005255	Protein of unknown function (DUF3168); Region: DUF3168; pfam11367
430066005256	Predicted secreted protein [Function unknown]; Region: COG5437
430066005257	Protein of unknown function (DUF3356); Region: DUF3356; pfam11836
430066005258	Phage-related minor tail protein [Function unknown]; Region: COG5281
430066005259	TIGR02217 family protein; Region: chp_TIGR02217
430066005260	Uncharacterized conserved protein (DUF2163); Region: DUF2163; pfam09931
430066005261	Uncharacterized conserved protein [Function unknown]; Region: COG5449
430066005262	Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791
430066005263	putative phage cell wall peptidase, NlpC/P60 family; Region: phage_NlpC_fam; TIGR02219
430066005264	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
430066005265	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
430066005266	active site
430066005267	phosphorylation site [posttranslational modification]
430066005268	intermolecular recognition site; other site
430066005269	dimerization interface [polypeptide binding]; other site
430066005270	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
430066005271	DNA binding site [nucleotide binding]
430066005272	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
430066005273	HAMP domain; Region: HAMP; pfam00672
430066005274	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
430066005275	ATP binding site [chemical binding]; other site
430066005276	Mg2+ binding site [ion binding]; other site
430066005277	G-X-G motif; other site
430066005278	Surface antigen [Cell envelope biogenesis, outer membrane]; Region: LipA; COG4520
430066005279	Cytochrome c biogenesis factor [Posttranslational modification, protein turnover, chaperones]; Region: COG4235
430066005280	cytochrome c-type biogenesis protein CcmI; Region: cytochro_ccmI; TIGR03142
430066005281	cytochrome c-type biogenesis protein CcmE; Reviewed; Region: PRK13254
430066005282	Cytochrome c biogenesis factor [Posttranslational modification, protein turnover, chaperones]; Region: CcmF; COG1138
430066005283	Uncharacterized protein involved in biosynthesis of c-type cytochromes [Posttranslational modification, protein turnover, chaperones]; Region: CcmH; COG3088
430066005284	periplasmic serine protease, Do/DeqQ family; Region: degP_htrA_DO; TIGR02037
430066005285	Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365
430066005286	PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987
430066005287	protein binding site [polypeptide binding]; other site
430066005288	PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987
430066005289	protein binding site [polypeptide binding]; other site
430066005290	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
430066005291	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
430066005292	active site
430066005293	phosphorylation site [posttranslational modification]
430066005294	intermolecular recognition site; other site
430066005295	dimerization interface [polypeptide binding]; other site
430066005296	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
430066005297	DNA binding site [nucleotide binding]
430066005298	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
430066005299	Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326
430066005300	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
430066005301	dimerization interface [polypeptide binding]; other site
430066005302	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
430066005303	dimer interface [polypeptide binding]; other site
430066005304	phosphorylation site [posttranslational modification]
430066005305	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
430066005306	ATP binding site [chemical binding]; other site
430066005307	Mg2+ binding site [ion binding]; other site
430066005308	G-X-G motif; other site
430066005309	bifunctional glutamine-synthetase adenylyltransferase/deadenyltransferase; Provisional; Region: PRK14108
430066005310	Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401
430066005311	metal binding triad; other site
430066005312	GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335
430066005313	Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401
430066005314	metal binding triad; other site
430066005315	Glycosyltransferase family 25 [lipooligosaccharide (LOS) biosynthesis protein] is a family of glycosyltransferases involved in LOS biosynthesis. The members include the beta(1,4) galactosyltransferases: Lgt2 of Moraxella catarrhalis, LgtB and LgtE of...; Region: Glyco_transf_25; cd06532
430066005316	Glycosyltransferase family 25 [lipooligosaccharide (LOS) biosynthesis protein] is a family of glycosyltransferases involved in LOS biosynthesis. The members include the beta(1,4) galactosyltransferases: Lgt2 of Moraxella catarrhalis, LgtB and LgtE of...; Region: Glyco_transf_25; cl01298
430066005317	O-Antigen ligase; Region: Wzy_C; pfam04932
430066005318	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
430066005319	PAS fold; Region: PAS_3; pfam08447
430066005320	putative active site [active]
430066005321	heme pocket [chemical binding]; other site
430066005322	phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966
430066005323	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
430066005324	dimer interface [polypeptide binding]; other site
430066005325	phosphorylation site [posttranslational modification]
430066005326	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
430066005327	ATP binding site [chemical binding]; other site
430066005328	Mg2+ binding site [ion binding]; other site
430066005329	G-X-G motif; other site
430066005330	aminopeptidase N; Provisional; Region: pepN; PRK14015
430066005331	Peptidase M1 family containing Aminopeptidase N; Region: M1_APN_1; cd09600
430066005332	active site
430066005333	Zn binding site [ion binding]; other site
430066005334	Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697
430066005335	EamA-like transporter family; Region: EamA; pfam00892
430066005336	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
430066005337	Major Facilitator Superfamily; Region: MFS_1; pfam07690
430066005338	putative substrate translocation pore; other site
430066005339	Family 4 Uracil-DNA glycosylase (UDG), found exclusively in thermophilic organisms; Region: UDG_F4_TTUDGA_like; cd10030
430066005340	Fe-S cluster binding site [ion binding]; other site
430066005341	active site
430066005342	Dehydrogenases (flavoproteins) [Energy production and conversion]; Region: FixC; COG0644
430066005343	hydroxyglutarate oxidase; Provisional; Region: PRK11728
430066005344	Electron transfer flavoprotein-ubiquinone oxidoreductase; Region: ETF_QO; pfam05187
430066005345	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3021
430066005346	putative catalytic site [active]
430066005347	putative metal binding site [ion binding]; other site
430066005348	putative phosphate binding site [ion binding]; other site
430066005349	AMP nucleosidase; Provisional; Region: PRK08292
430066005350	Bacterial AMP nucleoside phosphorylase N-terminus; Region: AMNp_N; pfam10423
430066005351	Nucleoside phosphorylase [Nucleotide transport and metabolism]; Region: Pfs; COG0775
430066005352	GST_N family, Ure2p-like subfamily; composed of the Saccharomyces cerevisiae Ure2p and related GSTs. Ure2p is a regulator for nitrogen catabolism in yeast. It represses the expression of several gene products involved in the use of poor nitrogen sources...; Region: GST_N_Ure2p_like; cd03048
430066005353	GSH-dependent disulfide bond oxidoreductase; Provisional; Region: PRK13972
430066005354	C-terminal domain interface [polypeptide binding]; other site
430066005355	GSH binding site (G-site) [chemical binding]; other site
430066005356	dimer interface [polypeptide binding]; other site
430066005357	C-terminal, alpha helical domain of Escherichia coli YfcG Glutathione S-transferases and related uncharacterized proteins; Region: GST_C_YfcG_like; cd10291
430066005358	N-terminal domain interface [polypeptide binding]; other site
430066005359	putative dimer interface [polypeptide binding]; other site
430066005360	active site
430066005361	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4731
430066005362	FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790
430066005363	Uncharacterized conserved protein [Function unknown]; Region: COG1284
430066005364	Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588
430066005365	Uncharacterized small membrane protein [Function unknown]; Region: COG2363
430066005366	histidinol-phosphate aminotransferase; Provisional; Region: PRK08153
430066005367	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
430066005368	pyridoxal 5'-phosphate binding site [chemical binding]; other site
430066005369	homodimer interface [polypeptide binding]; other site
430066005370	catalytic residue [active]
430066005371	tyrosine recombinase XerD; Region: recomb_XerD; TIGR02225
430066005372	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
430066005373	active site
430066005374	DNA binding site [nucleotide binding]
430066005375	Int/Topo IB signature motif; other site
430066005376	Porin subfamily; Region: Porin_2; pfam02530
430066005377	Brucella outer membrane protein 2; Region: Brucella_OMP2; pfam05244
430066005378	Uncharacterized conserved protein [Function unknown]; Region: COG3743
430066005379	Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741
430066005380	Lytic Transglycosylase (LT)  and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL).  LTs...; Region: LT_GEWL; cd00254
430066005381	N-acetyl-D-glucosamine binding site [chemical binding]; other site
430066005382	catalytic residue [active]
430066005383	Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329
430066005384	Dihydrodipicolinate synthase (DHDPS); Region: DHDPS; cd00950
430066005385	dimer interface [polypeptide binding]; other site
430066005386	active site
430066005387	catalytic residue [active]
430066005388	Small protein B (SmpB) is a component of the trans-translation system in prokaryotes for releasing stalled ribosome from damaged messenger RNAs; Region: SmpB; cd09294
430066005389	SmpB-tmRNA interface; other site
430066005390	Family-5 Uracil-DNA glycosylases (UDG), found in thermophilic organisms; Region: UDG_F5_TTUDGB_like; cd10031
430066005391	Fe-S cluster binding site [ion binding]; other site
430066005392	DNA binding site [nucleotide binding]
430066005393	active site
430066005394	Uncharacterized conserved protein [Function unknown]; Region: COG1432
430066005395	LabA_like proteins; Region: LabA; cd10911
430066005396	putative metal binding site [ion binding]; other site
430066005397	DNA-directed RNA polymerase subunit omega; Reviewed; Region: rpoZ; PRK00392
430066005398	Guanosine polyphosphate pyrophosphohydrolases/synthetases [Signal transduction mechanisms / Transcription]; Region: SpoT; COG0317
430066005399	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
430066005400	Zn2+ binding site [ion binding]; other site
430066005401	Mg2+ binding site [ion binding]; other site
430066005402	Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399
430066005403	synthetase active site [active]
430066005404	NTP binding site [chemical binding]; other site
430066005405	metal binding site [ion binding]; metal-binding site
430066005406	TGS_RelA_SpoT: The RelA (SpoT) protein, also referred to as ppGpp hydrolase/synthetase, is a ribosome-associated protein that is activated during amino acid starvation and thought to mediate the stringent response. RelA contains a TGS domain, named after...; Region: TGS_RelA_SpoT; cd01668
430066005407	ACT  domain found C-terminal of the RelA/SpoT domains; Region: ACT_RelA-SpoT; cd04876
430066005408	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
430066005409	active site
430066005410	cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664
430066005411	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
430066005412	ligand binding site [chemical binding]; other site
430066005413	flexible hinge region; other site
430066005414	helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092
430066005415	putative switch regulator; other site
430066005416	non-specific DNA interactions [nucleotide binding]; other site
430066005417	DNA binding site [nucleotide binding]
430066005418	sequence specific DNA binding site [nucleotide binding]; other site
430066005419	putative cAMP binding site [chemical binding]; other site
430066005420	coproporphyrinogen III oxidase; Provisional; Region: PRK13347
430066005421	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
430066005422	FeS/SAM binding site; other site
430066005423	HemN C-terminal domain; Region: HemN_C; pfam06969
430066005424	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
430066005425	Major Facilitator Superfamily; Region: MFS_1; pfam07690
430066005426	putative substrate translocation pore; other site
430066005427	AraC-like ligand binding domain; Region: AraC_binding; pfam02311
430066005428	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
430066005429	Helix-turn-helix domain; Region: HTH_18; pfam12833
430066005430	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
430066005431	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3216
430066005432	4'-phosphopantetheinyl transferase; Provisional; Region: acpS; PRK00070
430066005433	The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530
430066005434	Catalytic site [active]
430066005435	Signal peptidase, peptidase S26; Region: Peptidase_S26; pfam10502
430066005436	The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530
430066005437	ribonuclease III; Reviewed; Region: PRK12371
430066005438	RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in...; Region: RIBOc; cd00593
430066005439	dimerization interface [polypeptide binding]; other site
430066005440	active site
430066005441	metal binding site [ion binding]; metal-binding site
430066005442	Double-stranded RNA binding motif. Binding is not sequence specific but is highly specific for double stranded RNA. Found in a variety of proteins including dsRNA dependent protein kinase PKR, RNA helicases, Drosophila staufen protein, E. coli RNase III; Region: DSRM; cd00048
430066005443	dsRNA binding site [nucleotide binding]; other site
430066005444	GTPase Era; Reviewed; Region: era; PRK00089
430066005445	E. coli Ras-like protein (Era) is a multifunctional GTPase; Region: Era; cd04163
430066005446	G1 box; other site
430066005447	GTP/Mg2+ binding site [chemical binding]; other site
430066005448	Switch I region; other site
430066005449	G2 box; other site
430066005450	Switch II region; other site
430066005451	G3 box; other site
430066005452	G4 box; other site
430066005453	G5 box; other site
430066005454	KH domain; Region: KH_2; pfam07650
430066005455	Recombination protein O N terminal; Region: RecO_N; pfam11967
430066005456	DNA repair protein RecO; Region: reco; TIGR00613
430066005457	Recombination protein O C terminal; Region: RecO_C; pfam02565
430066005458	Predicted protein tyrosine phosphatase [General function prediction only]; Region: COG5350
430066005459	Predicted hydrolases of HD superfamily [General function prediction only]; Region: COG1896
430066005460	Predicted aminomethyltransferase related to GcvT [General function prediction only]; Region: COG0354
430066005461	folate-binding protein YgfZ; Region: ygfZ_signature; TIGR03317
430066005462	Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669
430066005463	dihydroorotase; Validated; Region: PRK09060
430066005464	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
430066005465	Dihydroorotase (DHOase), subgroup IIb; DHOases catalyze the reversible interconversion of carbamoyl aspartate to dihydroorotate, a key reaction in pyrimidine biosynthesis. This group contains the archeal members of the DHOase family; Region: DHOase_IIb; cd01318
430066005466	active site
430066005467	Protein of unknown function (DUF2385); Region: DUF2385; cl11490
430066005468	Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_15; cd04673
430066005469	nudix motif; other site
430066005470	Uncharacterized conserved protein [Function unknown]; Region: COG2135
430066005471	Lysine efflux permease [General function prediction only]; Region: COG1279
430066005472	cysteinyl-tRNA synthetase; Validated; Region: cysS; PRK00260
430066005473	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
430066005474	active site
430066005475	HIGH motif; other site
430066005476	nucleotide binding site [chemical binding]; other site
430066005477	catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672
430066005478	KMSKS motif; other site
430066005479	Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020
430066005480	putative alpha-isopropylmalate/homocitrate synthase family transferase; Provisional; Region: PRK12344
430066005481	Desulfobacterium autotrophicum LeuA3 and related proteins, N-terminal catalytic TIM barrel domain; Region: DRE_TIM_LeuA3; cd07941
430066005482	active site
430066005483	catalytic residues [active]
430066005484	metal binding site [ion binding]; metal-binding site
430066005485	LeuA allosteric (dimerisation) domain; Region: LeuA_dimer; smart00917
430066005486	Predicted permeases [General function prediction only]; Region: RarD; COG2962
430066005487	Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739
430066005488	Peptidase family M23; Region: Peptidase_M23; pfam01551
430066005489	16S ribosomal RNA methyltransferase KsgA/Dim1 family protein; Reviewed; Region: ksgA; PRK00274
430066005490	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
430066005491	S-adenosylmethionine binding site [chemical binding]; other site
430066005492	4-hydroxythreonine-4-phosphate dehydrogenase; Provisional; Region: pdxA; PRK05312
430066005493	4-hydroxythreonine-4-phosphate dehydrogenase; Validated; Region: pdxA; PRK03743
430066005494	Parvulin-like peptidyl-prolyl isomerase [Posttranslational modification, protein turnover, chaperones]; Region: SurA; COG0760
430066005495	SurA N-terminal domain; Region: SurA_N; pfam09312
430066005496	Organic solvent tolerance protein OstA [Cell envelope biogenesis, outer membrane]; Region: Imp; COG1452
430066005497	OstA-like protein; Region: OstA; cl00844
430066005498	Organic solvent tolerance protein; Region: OstA_C; pfam04453
430066005499	Predicted permeases [General function prediction only]; Region: COG0795
430066005500	Predicted permease YjgP/YjgQ family; Region: YjgP_YjgQ; pfam03739
430066005501	Predicted permeases [General function prediction only]; Region: COG0795
430066005502	Predicted permease YjgP/YjgQ family; Region: YjgP_YjgQ; pfam03739
430066005503	multifunctional aminopeptidase A; Provisional; Region: PRK00913
430066005504	Cytosol aminopeptidase family, N-terminal and catalytic domains.  Family M17 contains zinc- and manganese-dependent exopeptidases ( EC  3.4.11.1), including leucine aminopeptidase. They catalyze removal of amino acids from the N-terminus of a protein and...; Region: Peptidase_M17; cd00433
430066005505	interface (dimer of trimers) [polypeptide binding]; other site
430066005506	Substrate-binding/catalytic site; other site
430066005507	Zn-binding sites [ion binding]; other site
430066005508	DNA polymerase III subunit chi; Validated; Region: PRK05728
430066005509	ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488
430066005510	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
430066005511	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
430066005512	Walker A/P-loop; other site
430066005513	ATP binding site [chemical binding]; other site
430066005514	ABC transporter signature motif; other site
430066005515	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
430066005516	Walker B; other site
430066005517	D-loop; other site
430066005518	ABC transporter; Region: ABC_tran_2; pfam12848
430066005519	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
430066005520	Uncharacterized protein conserved in bacteria [Function unknown]; Region: DinB; COG2318
430066005521	DinB superfamily; Region: DinB_2; pfam12867
430066005522	Nucleoside diphosphate kinase Group I (NDPk_I)-like: NDP kinase domains are present in a large family of structurally and functionally conserved proteins from bacteria to humans that generally catalyze the transfer of gamma-phosphates of a nucleoside...; Region: NDPk_I; cd04413
430066005523	active site
430066005524	multimer interface [polypeptide binding]; other site
430066005525	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3126
430066005526	Heat shock protein [Posttranslational modification, protein turnover, chaperones]; Region: HslJ; COG3187
430066005527	MoaE family. Members of this family are involved in biosynthesis of the molybdenum cofactor (Moco), an essential cofactor for a diverse group of redox enzymes. Moco biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoaE; cd00756
430066005528	MoaE homodimer interface [polypeptide binding]; other site
430066005529	MoaD interaction [polypeptide binding]; other site
430066005530	active site residues [active]
430066005531	Ubiquitin domain of MoaD-like proteins; Region: MoaD; cd00754
430066005532	MoaE interaction surface [polypeptide binding]; other site
430066005533	MoeB interaction surface [polypeptide binding]; other site
430066005534	thiocarboxylated glycine; other site
430066005535	CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; cl00453
430066005536	excinuclease ABC subunit C; Validated; Region: uvrC; PRK00558
430066005537	Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434
430066005538	GIY-YIG motif/motif A; other site
430066005539	active site
430066005540	catalytic site [active]
430066005541	putative DNA binding site [nucleotide binding]; other site
430066005542	metal binding site [ion binding]; metal-binding site
430066005543	UvrC Helix-hairpin-helix N-terminal; Region: UvrC_HhH_N; pfam08459
430066005544	endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cl14786
430066005545	short chain dehydrogenase; Provisional; Region: PRK09134
430066005546	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
430066005547	NAD(P) binding site [chemical binding]; other site
430066005548	active site
430066005549	Opacity protein and related surface antigens [Cell envelope biogenesis, outer membrane]; Region: COG3637
430066005550	Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625
430066005551	GST_N family, unknown subfamily 3; composed of uncharacterized bacterial proteins with similarity to GSTs. GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of...; Region: GST_N_3; cd03049
430066005552	putative C-terminal domain interface [polypeptide binding]; other site
430066005553	putative GSH binding site (G-site) [chemical binding]; other site
430066005554	putative dimer interface [polypeptide binding]; other site
430066005555	C-terminal, alpha helical domain of an unknown subfamily 6 of Glutathione S-transferases; Region: GST_C_6; cd03205
430066005556	dimer interface [polypeptide binding]; other site
430066005557	N-terminal domain interface [polypeptide binding]; other site
430066005558	putative substrate binding pocket (H-site) [chemical binding]; other site
430066005559	Ribonuclease T2 (RNase T2) is a widespread family of secreted RNases found in every organism examined thus far.  This family includes RNase Rh, RNase MC1, RNase LE, and self-incompatibility RNases (S-RNases).  Plant T2 RNases are expressed during leaf...; Region: RNase_T2_prok; cd01062
430066005560	B1 nucleotide binding pocket [chemical binding]; other site
430066005561	B2 nucleotide binding pocket [chemical binding]; other site
430066005562	CAS motifs; other site
430066005563	active site
430066005564	Bacteriophage capsid protein [General function prediction only]; Region: COG5511
430066005565	Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates...; Region: NK; cl17190
430066005566	Protein involved in catabolism of external DNA [General function prediction only]; Region: ComJ; COG2961
430066005567	phosphonate utilization associated putative membrane protein; Region: phn_DUF6; TIGR03340
430066005568	Anaerobic dehydrogenases, typically selenocysteine-containing [Energy production and conversion]; Region: BisC; COG0243
430066005569	The MopB_3 CD includes a group of related uncharacterized bacterial and archaeal molybdopterin-binding oxidoreductase-like domains with a putative N-terminal iron-sulfur [4Fe-4S] cluster binding site and molybdopterin cofactor binding site. These members...; Region: MopB_3; cd02766
430066005570	putative [4Fe-4S] binding site [ion binding]; other site
430066005571	putative molybdopterin cofactor binding site [chemical binding]; other site
430066005572	The MopB_CT_3 CD includes a group of related uncharacterized bacterial molybdopterin-binding oxidoreductase-like domains with a putative N-terminal iron-sulfur [4Fe-4S] cluster binding site and molybdopterin cofactor binding site. This CD is of the...; Region: MopB_CT_3; cd02786
430066005573	putative molybdopterin cofactor binding site; other site
430066005574	Protein of unknown function (DUF992); Region: DUF992; pfam06186
430066005575	phosphoribosylglycinamide formyltransferase; Reviewed; Region: purN; PRK05647
430066005576	Phosphoribosylglycinamide formyltransferase (GAR transformylase, GART); Region: FMT_core_GART; cd08645
430066005577	active site
430066005578	substrate binding site [chemical binding]; other site
430066005579	cosubstrate binding site; other site
430066005580	catalytic site [active]
430066005581	phosphoribosylaminoimidazole synthetase; Provisional; Region: PRK05385
430066005582	PurM (Aminoimidazole Ribonucleotide [AIR] synthetase), one of eleven enzymes required for purine biosynthesis, catalyzes the conversion of formylglycinamide ribonucleotide (FGAM) and ATP to AIR, ADP, and Pi, the fifth step in de novo purine biosynthesis; Region: PurM; cd02196
430066005583	dimerization interface [polypeptide binding]; other site
430066005584	putative ATP binding site [chemical binding]; other site
430066005585	Domain of unknown function DUF20; Region: UPF0118; pfam01594
430066005586	Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628
430066005587	hypothetical protein; Validated; Region: PRK09087
430066005588	ATPase involved in DNA replication initiation [DNA replication, recombination, and repair]; Region: DnaA; COG0593
430066005589	Walker A motif; other site
430066005590	ATP binding site [chemical binding]; other site
430066005591	Walker B motif; other site
430066005592	arginine finger; other site
430066005593	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
430066005594	NAD dependent epimerase/dehydratase family; Region: Epimerase; pfam01370
430066005595	NAD(P) binding site [chemical binding]; other site
430066005596	active site
430066005597	putative beta-ketoacyl acyl carrier protein [ACP] reductase (BKR)-like, SDR; Region: BKR_like_SDR_like; cd05344
430066005598	3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK05565
430066005599	putative NAD(P) binding site [chemical binding]; other site
430066005600	putative active site [active]
430066005601	L-lactate permease; Region: Lactate_perm; cl00701
430066005602	L-lactate permease [Energy production and conversion]; Region: LldP; COG1620
430066005603	ETC complex I subunit conserved region; Region: ETC_C1_NDUFA4; pfam04800
430066005604	DEDDh 3'-5' exonuclease domain of Caenorhabditis elegans ERI-1, human 3' exonuclease, and similar proteins; Region: ERI-1_3'hExo_like; cd06133
430066005605	active site
430066005606	catalytic site [active]
430066005607	substrate binding site [chemical binding]; other site
430066005608	Archaeal adenylate kinase [Nucleotide transport and metabolism]; Region: AdkA; COG2019
430066005609	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
430066005610	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
430066005611	non-specific DNA binding site [nucleotide binding]; other site
430066005612	salt bridge; other site
430066005613	sequence-specific DNA binding site [nucleotide binding]; other site
430066005614	Uncharacterized conserved protein [Function unknown]; Region: COG4933
430066005615	Integrase core domain; Region: rve; pfam00665
430066005616	Mu transposase, C-terminal; Region: Mu-transpos_C; pfam09299
430066005617	AAA domain; Region: AAA_22; pfam13401
430066005618	AAA ATPase domain; Region: AAA_16; pfam13191
430066005619	Domain of unknown function (DUF955); Region: DUF955; pfam06114
430066005620	Uncharacterized protein containing a TIR (Toll-Interleukin 1-resistance) domain [Function unknown]; Region: COG4916
430066005621	TIR domain; Region: TIR_2; pfam13676
430066005622	Uncharacterized protein with a bacterial SH3 domain homologue [Function unknown]; Region: COG4991
430066005623	Bacterial SH3 domain; Region: SH3_3; pfam08239
430066005624	cystathionine beta-lyase; Provisional; Region: PRK05967
430066005625	CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614
430066005626	homodimer interface [polypeptide binding]; other site
430066005627	substrate-cofactor binding pocket; other site
430066005628	pyridoxal 5'-phosphate binding site [chemical binding]; other site
430066005629	catalytic residue [active]
430066005630	PAP2_like proteins, a super-family of histidine phosphatases and vanadium haloperoxidases, includes type 2 phosphatidic acid phosphatase or lipid phosphate phosphatase (LPP), Glucose-6-phosphatase, Phosphatidylglycerophosphatase B and bacterial acid...; Region: PAP2_like; cl00474
430066005631	Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671
430066005632	active site
430066005633	ABC-type amino acid transport system, permease component [Amino acid transport and metabolism]; Region: BatB; COG4597
430066005634	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
430066005635	conserved gate region; other site
430066005636	ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215
430066005637	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
430066005638	dimer interface [polypeptide binding]; other site
430066005639	conserved gate region; other site
430066005640	putative PBP binding loops; other site
430066005641	ABC-ATPase subunit interface; other site
430066005642	ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126
430066005643	ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262
430066005644	Walker A/P-loop; other site
430066005645	ATP binding site [chemical binding]; other site
430066005646	Q-loop/lid; other site
430066005647	ABC transporter signature motif; other site
430066005648	Walker B; other site
430066005649	D-loop; other site
430066005650	H-loop/switch region; other site
430066005651	salicylate hydroxylase; Provisional; Region: PRK06475
430066005652	salicylate hydroxylase; Provisional; Region: PRK08163
430066005653	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4391
430066005654	polyphosphate kinase; Provisional; Region: PRK05443
430066005655	Polyphosphate kinase N-terminal domain; Region: PP_kinase_N; pfam13089
430066005656	Polyphosphate kinase middle domain; Region: PP_kinase; pfam02503
430066005657	Catalytic C-terminal domain, first repeat, of Pseudomonas aeruginosa polyphosphate kinase 1 and similar proteins; Region: PLDc_PaPPK1_C1_like; cd09165
430066005658	putative domain interface [polypeptide binding]; other site
430066005659	putative active site [active]
430066005660	catalytic site [active]
430066005661	Catalytic C-terminal domain, second repeat, of Pseudomonas aeruginosa polyphosphate kinase 1 and similar proteins; Region: PLDc_PaPPK1_C2_like; cd09168
430066005662	putative domain interface [polypeptide binding]; other site
430066005663	putative active site [active]
430066005664	catalytic site [active]
430066005665	Exopolyphosphatase [Nucleotide transport and metabolism / Inorganic ion transport and metabolism]; Region: GppA; COG0248
430066005666	Ppx/GppA phosphatase family; Region: Ppx-GppA; pfam02541
430066005667	Ribonuclease D [Translation, ribosomal structure and biogenesis]; Region: Rnd; COG0349
430066005668	DEDDy 3'-5' exonuclease domain of Ribonuclease D and similar proteins; Region: RNaseD_exo; cd06142
430066005669	catalytic site [active]
430066005670	putative active site [active]
430066005671	putative substrate binding site [chemical binding]; other site
430066005672	HRDC domain; Region: HRDC; pfam00570
430066005673	aspartyl-tRNA synthetase; Validated; Region: aspS; PRK00476
430066005674	EcAspRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli aspartyl-tRNA synthetase (AspRS), the human mitochondrial (mt) AspRS-2, the discriminating (D) Thermus thermophilus AspRS-1, and the nondiscriminating (ND)...; Region: EcAspRS_like_N; cd04317
430066005675	dimer interface [polypeptide binding]; other site
430066005676	anticodon binding site; other site
430066005677	Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of...; Region: AspRS_core; cd00777
430066005678	homodimer interface [polypeptide binding]; other site
430066005679	motif 1; other site
430066005680	active site
430066005681	motif 2; other site
430066005682	GAD domain; Region: GAD; pfam02938
430066005683	Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA.   PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268
430066005684	active site
430066005685	motif 3; other site
430066005686	DNA topoisomerase IV subunit A; Validated; Region: PRK05561
430066005687	DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187
430066005688	CAP-like domain; other site
430066005689	active site
430066005690	primary dimer interface [polypeptide binding]; other site
430066005691	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
430066005692	Putative arginyl-tRNA:protein arginylyltransferase [Posttranslational modification, protein turnover, chaperones]; Region: COG2935
430066005693	Arginine-tRNA-protein transferase, N terminus; Region: ATE_N; pfam04376
430066005694	Arginine-tRNA-protein transferase, C terminus; Region: ATE_C; pfam04377
430066005695	Predicted membrane protein/domain [Function unknown]; Region: COG1714
430066005696	Porphobilinogen synthase (PBGS), which is also called delta-aminolevulinic acid dehydratase (ALAD), catalyzes the condensation of two 5-aminolevulinic acid (ALA) molecules to form the pyrrole porphobilinogen (PBG), which is the second step in the...; Region: ALAD_PBGS_aspartate_rich; cd04823
430066005697	dimer interface [polypeptide binding]; other site
430066005698	allosteric magnesium binding site [ion binding]; other site
430066005699	active site
430066005700	aspartate-rich active site metal binding site; other site
430066005701	Schiff base residues; other site
430066005702	3-hydroxyisobutyryl-CoA hydrolase; Provisional; Region: PRK05617
430066005703	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
430066005704	substrate binding site [chemical binding]; other site
430066005705	oxyanion hole (OAH) forming residues; other site
430066005706	trimer interface [polypeptide binding]; other site
430066005707	2-enoyl-CoA Hydratase C-terminal region; Region: ECH_C; pfam13766
430066005708	Transcriptional regulators [Transcription]; Region: MarR; COG1846
430066005709	Winged helix DNA-binding domain; Region: HTH_27; pfam13463
430066005710	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2989
430066005711	Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471
430066005712	L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734
430066005713	L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734
430066005714	serine hydroxymethyltransferase; Reviewed; Region: glyA; PRK00011
430066005715	Serine-glycine hydroxymethyltransferase (SHMT). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). SHMT carries out interconversion of serine and glycine; it catalyzes the transfer of hydroxymethyl...; Region: SHMT; cd00378
430066005716	dimer interface [polypeptide binding]; other site
430066005717	active site
430066005718	glycine-pyridoxal phosphate binding site [chemical binding]; other site
430066005719	folate binding site [chemical binding]; other site
430066005720	transcriptional regulator NrdR; Validated; Region: nrdR; PRK00464
430066005721	ATP cone domain; Region: ATP-cone; pfam03477
430066005722	riboflavin biosynthesis protein RibD; Region: eubact_ribD; TIGR00326
430066005723	Riboflavin-specific deaminase. Riboflavin biosynthesis protein RibD (Diaminohydroxyphosphoribosylaminopyrimidine deaminase) catalyzes the deamination of 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate, which is an intermediate step in the...; Region: Riboflavin_deaminase-reductase; cd01284
430066005724	catalytic motif [active]
430066005725	Zn binding site [ion binding]; other site
430066005726	RibD C-terminal domain; Region: RibD_C; cl17279
430066005727	riboflavin synthase subunit alpha; Provisional; Region: PRK09289
430066005728	Lumazine binding domain; Region: Lum_binding; pfam00677
430066005729	Lumazine binding domain; Region: Lum_binding; pfam00677
430066005730	lumazine synthase (6,7-dimethyl-8-ribityllumazine synthase, LS), catalyzes the penultimate step in the biosynthesis of riboflavin (vitamin B2); type-I; Region: Lumazine_synthase-I; cd09209
430066005731	homopentamer interface [polypeptide binding]; other site
430066005732	active site
430066005733	transcription antitermination protein NusB; Reviewed; Region: nusB; PRK00202
430066005734	putative RNA binding site [nucleotide binding]; other site
430066005735	Inorganic pyrophosphatase [Energy production and conversion]; Region: OVP1; COG3808
430066005736	H(+) -translocating inorganic pyrophosphatase; Region: PLN02255; cl11452
430066005737	Outer membrane lipoprotein OmlA (small protein A) [Cell envelope biogenesis, outer membrane]; Region: OlmA; COG2913
430066005738	SmpA / OmlA family; Region: SmpA_OmlA; pfam04355
430066005739	Uncharacterized conserved protein [Function unknown]; Region: COG5452
430066005740	Uncharacterized ACR, COG1399; Region: DUF177; pfam02620
430066005741	putative phosphate acyltransferase; Provisional; Region: PRK05331
430066005742	3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK09352
430066005743	Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830
430066005744	dimer interface [polypeptide binding]; other site
430066005745	active site
430066005746	CoA binding pocket [chemical binding]; other site
430066005747	Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591
430066005748	IHF dimer interface [polypeptide binding]; other site
430066005749	IHF - DNA interface [nucleotide binding]; other site
430066005750	Helix-Turn-Helix DNA binding domain of putative MlrA-like transcription regulators; Region: HTH_MlrA-like_sg2; cd04765
430066005751	MerR HTH family regulatory protein; Region: MerR_1; pfam13411
430066005752	DNA binding residues [nucleotide binding]
430066005753	Small Multidrug Resistance protein; Region: Multi_Drug_Res; cl00910
430066005754	exopolysaccharide biosynthesis polyprenyl glycosylphosphotransferase; Region: EPS_sugtrans; TIGR03025
430066005755	Sugar transferases involved in lipopolysaccharide synthesis [Cell envelope biogenesis, outer membrane]; Region: WcaJ; COG2148
430066005756	Polysaccharide biosynthesis/export protein; Region: Poly_export; pfam02563
430066005757	putative polysaccharide export protein, PEP-CTERM sytem-associated; Region: pepcterm_export; TIGR03027
430066005758	SLBB domain; Region: SLBB; pfam10531
430066005759	ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Mrp; COG0489
430066005760	Protein of unknown function (DUF2842); Region: DUF2842; pfam11003
430066005761	Uncharacterized protein required for cytochrome oxidase assembly [Posttranslational modification, protein turnover, chaperones]; Region: CtaA; COG1612
430066005762	Cytochrome oxidase assembly protein; Region: COX15-CtaA; cl15852
430066005763	N-acetyl-gamma-glutamyl-phosphate reductase; Provisional; Region: PRK11863
430066005764	Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859
430066005765	Agmatinase-like family includes proclavaminic acid amidinohydrolase; Region: Agmatinase_PAH; cd11592
430066005766	oligomer interface [polypeptide binding]; other site
430066005767	putative active site [active]
430066005768	Mn binding site [ion binding]; other site
430066005769	30S ribosomal protein S9; Reviewed; Region: rpsI; PRK00132
430066005770	Ribosomal protein L13.  Protein L13, a large ribosomal subunit protein, is one of five proteins required for an early folding intermediate of 23S rRNA in the assembly of the large subunit. L13 is situated on the bottom of the large subunit, near the...; Region: Ribosomal_L13; cd00392
430066005771	23S rRNA interface [nucleotide binding]; other site
430066005772	L3 interface [polypeptide binding]; other site
430066005773	PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria.  Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443
430066005774	CoenzymeA binding site [chemical binding]; other site
430066005775	subunit interaction site [polypeptide binding]; other site
430066005776	PHB binding site; other site
430066005777	O-acetylhomoserine aminocarboxypropyltransferase; Validated; Region: PRK05994
430066005778	CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614
430066005779	homodimer interface [polypeptide binding]; other site
430066005780	substrate-cofactor binding pocket; other site
430066005781	pyridoxal 5'-phosphate binding site [chemical binding]; other site
430066005782	catalytic residue [active]
430066005783	NADH:ubiquinone oxidoreductase subunit A; Validated; Region: PRK06602
430066005784	NADH:ubiquinone oxidoreductase 20 kD subunit and related Fe-S oxidoreductases [Energy production and conversion]; Region: NuoB; COG0377
430066005785	NADH dehydrogenase subunit C; Provisional; Region: PRK06074
430066005786	NADH (or F420H2) dehydrogenase, subunit C; Region: NuoC_fam; TIGR01961
430066005787	NADH:ubiquinone oxidoreductase 49 kD subunit 7 [Energy production and conversion]; Region: NuoD; COG0649
430066005788	NADH dehydrogenase subunit D; Validated; Region: PRK06075
430066005789	NADH:ubiquinone oxidoreductase 24 kD subunit [Energy production and conversion]; Region: NuoE; COG1905
430066005790	TRX-like [2Fe-2S] Ferredoxin (Fd) family, NADH:ubiquinone oxidoreductase (Nuo) subunit E subfamily; Nuo, also called respiratory chain Complex 1, is the entry point for electrons into the respiratory chains of bacteria and the mitochondria of eukaryotes; Region: TRX_Fd_NuoE; cd03064
430066005791	putative dimer interface [polypeptide binding]; other site
430066005792	[2Fe-2S] cluster binding site [ion binding]; other site
430066005793	NADH dehydrogenase I subunit F; Provisional; Region: PRK13596
430066005794	SLBB domain; Region: SLBB; pfam10531
430066005795	NADH-ubiquinone oxidoreductase-F iron-sulfur binding region; Region: NADH_4Fe-4S; smart00928
430066005796	NADH dehydrogenase subunit G; Validated; Region: PRK09130
430066005797	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
430066005798	catalytic loop [active]
430066005799	iron binding site [ion binding]; other site
430066005800	NADH-ubiquinone oxidoreductase-G iron-sulfur binding region; Region: NADH-G_4Fe-4S_3; pfam10588
430066005801	MopB_Res_Cmplx1_Nad11: The second domain of the Nad11/75-kDa subunit of the NADH-quinone oxidoreductase/respiratory complex I/NADH dehydrogenase-1(NDH-1) of eukaryotes and the Nqo3/G subunit of alphaproteobacteria NDH-1. The NADH-quinone oxidoreductase...; Region: MopB_Res-Cmplx1_Nad11; cd02773
430066005802	Domain of unknown function (DUF1982); Region: DUF1982; pfam09326
430066005803	NADH:ubiquinone oxidoreductase subunit H; Provisional; Region: PRK06076
430066005804	Formate hydrogenlyase subunit 4 [Energy production and conversion]; Region: HyfC; COG0650
430066005805	NADH dehydrogenase subunit I; Provisional; Region: PRK05888
430066005806	4Fe-4S binding domain; Region: Fer4; pfam00037
430066005807	4Fe-4S binding domain; Region: Fer4; pfam00037
430066005808	NADH:ubiquinone oxidoreductase subunit J; Provisional; Region: PRK06638
430066005809	NADH dehydrogenase subunit 6; Provisional; Region: ND6; MTH00213
430066005810	NADH:ubiquinone oxidoreductase subunit K; Validated; Region: PRK05715
430066005811	NADH:ubiquinone oxidoreductase subunit L; Reviewed; Region: PRK06590
430066005812	NADH-Ubiquinone oxidoreductase (complex I), chain 5 N-terminus; Region: Oxidored_q1_N; pfam00662
430066005813	NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361
430066005814	NADH:ubiquinone oxidoreductase subunit M; Reviewed; Region: PRK05846
430066005815	NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361
430066005816	NADH:ubiquinone oxidoreductase subunit N; Provisional; Region: PRK05777
430066005817	NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361
430066005818	Biotin-(acetyl-CoA carboxylase) ligase [Coenzyme metabolism]; Region: BirA; COG0340
430066005819	Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; cl14057
430066005820	Biotin protein ligase C terminal domain; Region: BPL_C; pfam02237
430066005821	mRNA degradation ribonucleases J1/J2 (metallo-beta-lactamase superfamily) [Translation, ribosomal structure and biogenesis; Replication, recombination and repair]; Region: COG0595
430066005822	Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849
430066005823	RNA-metabolising metallo-beta-lactamase; Region: RMMBL; pfam07521
430066005824	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
430066005825	Methylmalonyl-CoA epimerase (MMCE); Region: MMCE; cd07249
430066005826	dimer interface [polypeptide binding]; other site
430066005827	substrate binding site [chemical binding]; other site
430066005828	metal binding site [ion binding]; metal-binding site
430066005829	Predicted secreted protein [Function unknown]; Region: COG5454
430066005830	prolyl-tRNA synthetase; Provisional; Region: PRK12325
430066005831	Prolyl-tRNA synthetase (ProRS) class II core catalytic domain. ProRS is a homodimer. It is responsible for the attachment of proline to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ProRS_core_prok; cd00779
430066005832	dimer interface [polypeptide binding]; other site
430066005833	motif 1; other site
430066005834	active site
430066005835	motif 2; other site
430066005836	Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA.   PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268
430066005837	active site
430066005838	motif 3; other site
430066005839	ProRS Prolyl-anticodon binding domain, short version found predominantly in bacteria. ProRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding; Region: ProRS_anticodon_short; cd00861
430066005840	anticodon binding site; other site
430066005841	lipoprotein releasing system, transmembrane protein, LolC/E family; Region: lolCE; TIGR02212
430066005842	MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
430066005843	FtsX-like permease family; Region: FtsX; pfam02687
430066005844	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
430066005845	ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255
430066005846	Walker A/P-loop; other site
430066005847	ATP binding site [chemical binding]; other site
430066005848	Q-loop/lid; other site
430066005849	ABC transporter signature motif; other site
430066005850	Walker B; other site
430066005851	D-loop; other site
430066005852	H-loop/switch region; other site
430066005853	DNA polymerase III subunit alpha; Validated; Region: dnaE; PRK05673
430066005854	Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III DnaE1; Region: PHP_PolIIIA_DnaE1; cd07433
430066005855	putative active site [active]
430066005856	putative PHP Thumb interface [polypeptide binding]; other site
430066005857	DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485
430066005858	generic binding surface II; other site
430066005859	generic binding surface I; other site
430066005860	Protein of unknwon function (DUF3008); Region: DUF3008; pfam11450
430066005861	30S ribosomal protein S4; Validated; Region: rpsD; PRK05327
430066005862	Ribosomal protein S4/S9 N-terminal domain; Region: Ribosomal_S4; pfam00163
430066005863	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
430066005864	RNA binding surface [nucleotide binding]; other site
430066005865	tRNA 2-thiocytidine biosynthesis protein TtcA; Provisional; Region: PRK10696
430066005866	This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases superfamily  includes N type ATP PPases and ATP sulphurylases. It forms a apha/beta/apha fold which  binds to Adenosine group.  This subfamily; Region: Alpha_ANH_like_II; cd01993
430066005867	Ligand Binding Site [chemical binding]; other site
430066005868	Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483
430066005869	PAP-phosphatase_like domains. PAP-phosphatase is a member of the inositol monophosphatase family, and catalyses the hydrolysis of 3'-phosphoadenosine-5'-phosphate (PAP) to AMP. In Saccharomyces cerevisiae, HAL2 (MET22) is involved in methionine...; Region: PAP_phosphatase; cd01517
430066005870	active site
430066005871	putative lithium-binding site [ion binding]; other site
430066005872	substrate binding site [chemical binding]; other site
430066005873	bicyclomycin/multidrug efflux system; Provisional; Region: PRK11102
430066005874	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
430066005875	putative substrate translocation pore; other site
430066005876	Glutaredoxin (GRX) family, PKC-interacting cousin of TRX (PICOT)-like subfamily; composed of PICOT and GRX-PICOT-like proteins. The non-PICOT members of this family contain only the GRX-like domain, whereas PICOT contains an N-terminal TRX-like domain...; Region: GRX_PICOT_like; cd03028
430066005877	putative GSH binding site [chemical binding]; other site
430066005878	catalytic residues [active]
430066005879	Stress-induced morphogen (activity unknown) [Signal transduction mechanisms]; Region: BolA; COG0271
430066005880	phosphoribosylformylglycinamidine synthase II; Provisional; Region: PRK01213
430066005881	PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), first repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat1; cd02203
430066005882	dimerization interface [polypeptide binding]; other site
430066005883	ATP binding site [chemical binding]; other site
430066005884	PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), second repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat2; cd02204
430066005885	dimerization interface [polypeptide binding]; other site
430066005886	ATP binding site [chemical binding]; other site
430066005887	Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625
430066005888	Glutathione S-transferase (GST) family, N-terminal domain; a large, diverse group of cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of  glutathione (GSH) with a wide range of endogenous and xenobiotic...; Region: GST_N_family; cd00570
430066005889	C-terminal domain interface [polypeptide binding]; other site
430066005890	GSH binding site (G-site) [chemical binding]; other site
430066005891	dimer interface [polypeptide binding]; other site
430066005892	C-terminal, alpha helical domain of the Glutathione S-transferase family; Region: GST_C_family; cd00299
430066005893	N-terminal domain interface [polypeptide binding]; other site
430066005894	dimer interface [polypeptide binding]; other site
430066005895	substrate binding pocket (H-site) [chemical binding]; other site
430066005896	phosphoribosylformylglycinamidine synthase I; Provisional; Region: PRK03619
430066005897	Type 1 glutamine amidotransferase (GATase1)-like domain found in Formylglycinamide ribonucleotide amidotransferase; Region: GATase1_FGAR_AT; cd01740
430066005898	putative active site [active]
430066005899	catalytic triad [active]
430066005900	phosphoribosylformylglycinamidine synthase subunit PurS; Reviewed; Region: PRK05974
430066005901	phosphoribosylaminoimidazole-succinocarboxamide synthase; Reviewed; Region: PRK09362
430066005902	bacterial and archaeal 5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide (SAICAR) synthase; Region: SAICAR_synt_PurC; cd01415
430066005903	ATP binding site [chemical binding]; other site
430066005904	active site
430066005905	substrate binding site [chemical binding]; other site
430066005906	Uncharacterized conserved protein [Function unknown]; Region: COG5467
430066005907	2,4-dihydroxyhept-2-ene-1,7-dioic acid aldolase [Carbohydrate transport and metabolism]; Region: HpcH; COG3836
430066005908	Predicted esterase of the alpha/beta hydrolase fold [General function prediction only]; Region: COG3545
430066005909	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
430066005910	Predicted ring-cleavage extradiol dioxygenase [General function prediction only]; Region: COG2514
430066005911	This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_12; cd07255
430066005912	putative metal binding site [ion binding]; other site
430066005913	This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632
430066005914	active site
430066005915	adenylosuccinate lyase; Provisional; Region: PRK07492
430066005916	Adenylsuccinate lyase (ASL)_subgroup 1; Region: Adenylsuccinate_lyase_1; cd01360
430066005917	tetramer interface [polypeptide binding]; other site
430066005918	active site
430066005919	Pentose-5-phosphate-3-epimerase [Carbohydrate transport and metabolism]; Region: Rpe; COG0036
430066005920	Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose...; Region: RPE; cd00429
430066005921	substrate binding site [chemical binding]; other site
430066005922	hexamer interface [polypeptide binding]; other site
430066005923	metal binding site [ion binding]; metal-binding site
430066005924	Bacterial lipid A biosynthesis acyltransferase; Region: Lip_A_acyltrans; pfam03279
430066005925	Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LABLAT-like; Region: LPLAT_LABLAT-like; cd07984
430066005926	putative acyl-acceptor binding pocket; other site
430066005927	NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604
430066005928	Alcohol dehydrogenases of the MDR family; Region: Zn_ADH_like1; cd08266
430066005929	putative NAD(P) binding site [chemical binding]; other site
430066005930	structural Zn binding site [ion binding]; other site
430066005931	3-oxoacyl-(acyl carrier protein) synthase II; Reviewed; Region: PRK06501
430066005932	Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834
430066005933	dimer interface [polypeptide binding]; other site
430066005934	active site
430066005935	3-oxoacyl-(acyl carrier protein) synthase II; Reviewed; Region: PRK06519
430066005936	Condensing enzymes; Family of enzymes that catalyze a (decarboxylating or non-decarboxylating) Claisen-like condensation reaction. Members are share strong structural similarity, and are involved in the synthesis and degradation of fatty acids, and the...; Region: cond_enzymes; cl09938
430066005937	active site
430066005938	acyl carrier protein; Provisional; Region: PRK06508
430066005939	Lysozyme family protein [General function prediction only]; Region: zliS; COG3926
430066005940	Glycosyl hydrolase 108; Region: Glyco_hydro_108; pfam05838
430066005941	Predicted Peptidoglycan domain; Region: PG_binding_3; pfam09374
430066005942	galactose mutarotase_like; Region: galactose_mutarotase_like; cd09019
430066005943	active site
430066005944	catalytic residues [active]
430066005945	Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524
430066005946	2-keto-3-deoxygluconate kinase (KdgK) phosphorylates 2-keto-3-deoxygluconate (KDG) to form 2-keto-3-deoxy-6-phosphogluconate (KDGP). KDG is the common intermediate product, that allows organisms to channel D-glucuronate and/or D-galacturinate into the...; Region: KdgK; cd01166
430066005947	substrate binding site [chemical binding]; other site
430066005948	ATP binding site [chemical binding]; other site
430066005949	putative phosphonate metabolism protein; Region: Phn_opern_protn; TIGR03223
430066005950	Metal-dependent hydrolase involved in phosphonate metabolism [Inorganic ion transport and metabolism]; Region: COG3454
430066005951	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
430066005952	PhnM is believed to be a subunit of the membrane associated C-P lyase complex. C-P lyase is thought to catalyze the direct cleavage of inactivated C-P bonds to yield inorganic phosphate and the corresponding hydrocarbons. It is responsible for cleavage...; Region: PhnM; cd01306
430066005953	active site
430066005954	haloacid dehalogenase-like hydrolase; Region: Hydrolase; pfam00702
430066005955	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
430066005956	active site
430066005957	motif I; other site
430066005958	motif II; other site
430066005959	lysine-arginine-ornithine-binding periplasmic protein; Region: 3A0103s03R; TIGR01096
430066005960	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
430066005961	substrate binding pocket [chemical binding]; other site
430066005962	membrane-bound complex binding site; other site
430066005963	hinge residues; other site
430066005964	tRNA-dihydrouridine synthase A; Provisional; Region: PRK11815
430066005965	Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801
430066005966	FMN binding site [chemical binding]; other site
430066005967	active site
430066005968	catalytic residues [active]
430066005969	substrate binding site [chemical binding]; other site
430066005970	Predicted aspartyl protease [General function prediction only]; Region: COG3577
430066005971	Bacterial aspartate proteases, retropepsin-like protease family; Region: retropepsin_like_bacteria; cd05483
430066005972	catalytic motif [active]
430066005973	Catalytic residue [active]
430066005974	Protein of unknown function (DUF1289); Region: DUF1289; pfam06945
430066005975	cobalamin synthase; Reviewed; Region: cobS; PRK00235
430066005976	Phosphoribosyltransferase; Region: DBI_PRT; pfam02277
430066005977	Nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase (DMB-PRT), also called CobT; Region: DMB-PRT_CobT; cd02439
430066005978	putative dimer interface [polypeptide binding]; other site
430066005979	active site pocket [active]
430066005980	putative cataytic base [active]
430066005981	Transcriptional regulators [Transcription]; Region: Lrp; COG1522
430066005982	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
430066005983	putative DNA binding site [nucleotide binding]; other site
430066005984	putative Zn2+ binding site [ion binding]; other site
430066005985	AsnC family; Region: AsnC_trans_reg; pfam01037
430066005986	Uncharacterized subfamily of Uracil-DNA glycosylases; Region: UDG_like_1; cd10033
430066005987	putative uracil binding site [chemical binding]; other site
430066005988	putative active site [active]
430066005989	Micrococcal nuclease (thermonuclease) homologs [DNA replication, recombination, and repair]; Region: COG1525
430066005990	Staphylococcal nuclease homologues. SNase homologues are found in bacteria, archaea, and eukaryotes. They contain no disufide bonds; Region: SNc; cl00140
430066005991	Catalytic site; other site
430066005992	FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790
430066005993	Sel1-like repeats; Region: SEL1; smart00671
430066005994	Escherichia coli exonuclease III (ExoIII) and Neisseria meningitides NExo-like subfamily of the ExoIII family purinic/apyrimidinic (AP) endonucleases; Region: ExoIII-like_AP-endo; cd09086
430066005995	putative catalytic site [active]
430066005996	putative phosphate binding site [ion binding]; other site
430066005997	active site
430066005998	metal binding site A [ion binding]; metal-binding site
430066005999	DNA binding site [nucleotide binding]
430066006000	putative AP binding site [nucleotide binding]; other site
430066006001	putative metal binding site B [ion binding]; other site
430066006002	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2979
430066006003	tellurium resistance terB-like protein, subgroup 3; Region: terB_like_YebE; cd07178
430066006004	putative metal binding site [ion binding]; other site
430066006005	Fe-S cluster assembly scaffold protein [Posttranslational modification, protein turnover, chaperones]; Region: sufA; COG0316
430066006006	deoxyguanosinetriphosphate triphosphohydrolase-like protein; Provisional; Region: PRK01286
430066006007	Phosphohydrolase-associated domain; Region: HD_assoc; pfam13286
430066006008	Arginyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Region: ArgS; COG0018
430066006009	Arginyl tRNA synthetase N terminal dom; Region: Arg_tRNA_synt_N; smart01016
430066006010	catalytic core domain of arginyl-tRNA synthetases; Region: ArgRS_core; cd00671
430066006011	active site
430066006012	HIGH motif; other site
430066006013	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
430066006014	KMSK motif region; other site
430066006015	tRNA binding surface [nucleotide binding]; other site
430066006016	DALR anticodon binding domain; Region: DALR_1; smart00836
430066006017	anticodon binding site; other site
430066006018	Sporulation related domain; Region: SPOR; pfam05036
430066006019	Beta-glucosidase-related glycosidases [Carbohydrate transport and metabolism]; Region: BglX; COG1472
430066006020	Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; cl07971
430066006021	Rec8/ScpA/Scc1-like protein (kleisin family) [Replication,    recombination, and repair]; Region: scpA; COG1354
430066006022	Chromosome segregation and condensation protein B [DNA replication, recombination and repair]; Region: scpB; COG1386
430066006023	twin arginine translocase protein A; Provisional; Region: tatA; PRK00720
430066006024	sec-independent translocase; Provisional; Region: PRK00708
430066006025	twin arginine-targeting protein translocase TatB; Region: tatB; TIGR01410
430066006026	Sec-independent protein secretion pathway component TatC [Intracellular trafficking and secretion]; Region: TatC; COG0805
430066006027	seryl-tRNA synthetase; Provisional; Region: PRK05431
430066006028	Seryl-tRNA synthetase N-terminal domain; Region: Seryl_tRNA_N; pfam02403
430066006029	Seryl-tRNA synthetase (SerRS) class II core catalytic domain. SerRS is responsible for the attachment of serine to the 3' OH group of ribose of the appropriate tRNA. This domain It is primarily responsible for ATP-dependent formation of the enzyme...; Region: SerRS_core; cd00770
430066006030	dimer interface [polypeptide binding]; other site
430066006031	active site
430066006032	motif 1; other site
430066006033	motif 2; other site
430066006034	motif 3; other site
430066006035	5'(3')-nucleotidase/polyphosphatase; Provisional; Region: surE; PRK00346
430066006036	protein-L-isoaspartate O-methyltransferase; Reviewed; Region: pcm; PRK00312
430066006037	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
430066006038	S-adenosylmethionine binding site [chemical binding]; other site
430066006039	Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739
430066006040	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
430066006041	Peptidase family M23; Region: Peptidase_M23; pfam01551
430066006042	Predicted ATPase (AAA+ superfamily) [General function prediction only]; Region: COG2607
430066006043	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
430066006044	Walker A motif; other site
430066006045	ATP binding site [chemical binding]; other site
430066006046	Walker B motif; other site
430066006047	Preprotein translocase subunit YajC [Intracellular trafficking and secretion]; Region: YajC; COG1862
430066006048	bifunctional preprotein translocase subunit SecD/SecF; Reviewed; Region: PRK13023
430066006049	protein-export membrane protein, SecD/SecF family; Region: 2A0604s01; TIGR00916
430066006050	SecD/SecF GG Motif; Region: Sec_GG; pfam07549
430066006051	Protein export membrane protein; Region: SecD_SecF; pfam02355
430066006052	Mth938-like domain. The members of this family include: Mth938, 2P1, Xcr35, Rpa2829, and several uncharacterized sequences. Mth938 is a hypothetical protein encoded by the Methanobacterium thermoautotrophicum (Mth) genome. This protein crystallizes as a...; Region: Mth938-like; cd00248
430066006053	Phytoene/squalene synthetase [Lipid metabolism]; Region: ERG9; COG1562
430066006054	substrate binding pocket [chemical binding]; other site
430066006055	substrate-Mg2+ binding site; other site
430066006056	aspartate-rich region 1; other site
430066006057	aspartate-rich region 2; other site
430066006058	tRNA (uracil-5-)-methyltransferase Gid; Reviewed; Region: PRK05335
430066006059	Glucose inhibited division protein A; Region: GIDA; pfam01134
430066006060	Uncharacterized conserved small protein [Function unknown]; Region: COG5457
430066006061	Predicted membrane protein [Function unknown]; Region: COG4872
430066006062	Uncharacterized membrane-anchored protein [Function unknown]; Region: COG4929
430066006063	trigger factor; Provisional; Region: tig; PRK01490
430066006064	FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254
430066006065	Bacterial trigger factor protein (TF) C-terminus; Region: Trigger_C; pfam05698
430066006066	aspartyl/glutamyl-tRNA amidotransferase subunit B; Validated; Region: gatB; PRK05477
430066006067	GatB/GatE catalytic domain; Region: GatB_N; pfam02934
430066006068	GatB domain; Region: GatB_Yqey; smart00845
430066006069	ribosomal-protein-alanine acetyltransferase; Region: rimI; TIGR01575
430066006070	Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583
430066006071	NADH dehydrogenase; Validated; Region: PRK08183
430066006072	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4765
430066006073	leucyl/phenylalanyl-tRNA--protein transferase; Reviewed; Region: aat; PRK00301
430066006074	acetyl-CoA carboxylase biotin carboxylase subunit; Validated; Region: PRK08591
430066006075	Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289
430066006076	Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786
430066006077	Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878
430066006078	acetyl-CoA carboxylase biotin carboxyl carrier protein subunit; Validated; Region: PRK06302
430066006079	The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850
430066006080	carboxyltransferase (CT) interaction site; other site
430066006081	biotinylation site [posttranslational modification]; other site
430066006082	Dehydroquinase class II; Region: DHquinase_II; pfam01220
430066006083	Dehydroquinase (DHQase), type II. Dehydroquinase (or 3-dehydroquinate dehydratase) catalyzes the reversible dehydration of 3-dehydroquinate to form 3-dehydroshikimate. This reaction is part of two metabolic pathways: the biosynthetic shikimate pathway...; Region: DHQase_II; cd00466
430066006084	trimer interface [polypeptide binding]; other site
430066006085	active site
430066006086	dimer interface [polypeptide binding]; other site
430066006087	Protein-disulfide isomerase [Posttranslational modification, protein turnover, chaperones]; Region: DsbG; COG1651
430066006088	DsbA family, Com1-like subfamily; composed of proteins similar to Com1, a 27-kDa outer membrane-associated immunoreactive protein originally found in both acute and chronic disease strains of the pathogenic bacteria Coxiella burnetti. It contains a CXXC...; Region: DsbA_Com1_like; cd03023
430066006089	catalytic residues [active]
430066006090	Putative Zn-dependent protease, contains TPR repeats [General function prediction only]; Region: COG4783
430066006091	Peptidase family M48; Region: Peptidase_M48; cl12018
430066006092	aspartate aminotransferase; Provisional; Region: PRK05764
430066006093	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
430066006094	pyridoxal 5'-phosphate binding site [chemical binding]; other site
430066006095	homodimer interface [polypeptide binding]; other site
430066006096	catalytic residue [active]
430066006097	S1_RNase_E: RNase E and RNase G, S1-like RNA-binding domain. RNase E is an essential endoribonuclease in the processing and degradation of RNA. In addition to its role in mRNA degradation, RNase E has also been implicated in the processing of rRNA, and...; Region: S1_RNase_E; cd04453
430066006098	S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927
430066006099	Ribonuclease E/G family; Region: RNase_E_G; pfam10150
430066006100	AMIN domain; Region: AMIN; pfam11741
430066006101	N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860
430066006102	N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696
430066006103	active site
430066006104	metal binding site [ion binding]; metal-binding site
430066006105	Membrane carboxypeptidase/penicillin-binding protein [Cell envelope biogenesis, outer membrane]; Region: MrcA; COG5009
430066006106	Transglycosylase; Region: Transgly; pfam00912
430066006107	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905
430066006108	peptide chain release factor 2; Provisional; Region: PRK07342
430066006109	This domain is found in peptide chain release factors; Region: PCRF; smart00937
430066006110	RF-1 domain; Region: RF-1; pfam00472
430066006111	Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340
430066006112	Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586
430066006113	Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cd00657
430066006114	dinuclear metal binding motif [ion binding]; other site
430066006115	Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450
430066006116	Peroxiredoxin (PRX) family, Bacterioferritin comigratory protein (BCP) subfamily; composed of thioredoxin-dependent thiol peroxidases, widely expressed in pathogenic bacteria, that protect cells against toxicity from reactive oxygen species by reducing...; Region: PRX_BCP; cd03017
430066006117	catalytic triad [active]
430066006118	AsmA family; Region: AsmA; pfam05170
430066006119	tyrosyl-tRNA synthetase; Validated; Region: PRK05912
430066006120	catalytic core domain of tyrosinyl-tRNA synthetase; Region: TyrRS_core; cd00805
430066006121	active site
430066006122	HIGH motif; other site
430066006123	dimer interface [polypeptide binding]; other site
430066006124	KMSKS motif; other site
430066006125	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
430066006126	RNA binding surface [nucleotide binding]; other site
430066006127	Predicted molecular chaperone distantly related to HSP70-fold metalloproteases [Posttranslational modification, protein turnover, chaperones]; Region: COG2377
430066006128	Small Multidrug Resistance protein; Region: Multi_Drug_Res; cl00910
430066006129	Predicted hydrolase of the alpha/beta superfamily [General function prediction only]; Region: COG2945
430066006130	Cysteine sulfinate desulfinase/cysteine desulfurase and related enzymes [Amino acid transport and metabolism]; Region: NifS; COG1104
430066006131	cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402
430066006132	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
430066006133	catalytic residue [active]
430066006134	cysteine desulfurase activator complex subunit SufB; Provisional; Region: PRK11814
430066006135	putative ABC transporter; Region: ycf24; CHL00085
430066006136	Cysteine desulfurase activator ATPase [Posttranslational modification, protein turnover, chaperones]; Region: sufC; COG0396
430066006137	ABC-type transport system involved in Fe-S cluster assembly, ATPase component; Region: ABC_FeS_Assembly; cd03217
430066006138	Walker A/P-loop; other site
430066006139	ATP binding site [chemical binding]; other site
430066006140	Q-loop/lid; other site
430066006141	ABC transporter signature motif; other site
430066006142	Walker B; other site
430066006143	D-loop; other site
430066006144	H-loop/switch region; other site
430066006145	Cysteine desulfurase activator SufB [Posttranslational modification, protein turnover, chaperones]; Region: SufB; COG0719
430066006146	FeS assembly protein SufD; Region: sufD; TIGR01981
430066006147	Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520
430066006148	Cysteine desulfurase (SufS)-like. This family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to cysteine desulfurase (SufS) and selenocysteine lyase. SufS...; Region: SufS_like; cd06453
430066006149	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
430066006150	catalytic residue [active]
430066006151	FeS assembly SUF system protein; Region: SUF_assoc; TIGR02945
430066006152	Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641
430066006153	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761
430066006154	active site
430066006155	Glycosyl transferase family group 2; Region: Glyco_trans_2_3; pfam13632
430066006156	ATP-NAD kinase; Region: NAD_kinase; pfam01513
430066006157	inorganic polyphosphate/ATP-NAD kinase; Reviewed; Region: ppnK; PRK04761
430066006158	ATP-dependent RNA helicase SrmB; Provisional; Region: PRK11192
430066006159	DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker  B motif; Region: DEADc; cd00268
430066006160	ATP binding site [chemical binding]; other site
430066006161	Mg++ binding site [ion binding]; other site
430066006162	motif III; other site
430066006163	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
430066006164	nucleotide binding region [chemical binding]; other site
430066006165	ATP-binding site [chemical binding]; other site
430066006166	FeS assembly scaffold SufA; Region: sufA_proteo; TIGR01997
430066006167	Copper chaperone [Inorganic ion transport and metabolism]; Region: CopZ; COG2608
430066006168	metal-binding site [ion binding]
430066006169	Protein-L-isoaspartate carboxylmethyltransferase [Posttranslational modification, protein turnover, chaperones]; Region: Pcm; COG2518
430066006170	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
430066006171	S-adenosylmethionine binding site [chemical binding]; other site
430066006172	type I secretion outer membrane protein, TolC family; Region: type_I_sec_TolC; TIGR01844
430066006173	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3827
430066006174	valyl-tRNA synthetase; Reviewed; Region: valS; PRK05729
430066006175	catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817
430066006176	HIGH motif; other site
430066006177	Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603
430066006178	catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817
430066006179	active site
430066006180	KMSKS motif; other site
430066006181	Anticodon-binding domain of valyl tRNA synthetases; Region: Anticodon_Ia_Val; cd07962
430066006182	tRNA binding surface [nucleotide binding]; other site
430066006183	anticodon binding site; other site
430066006184	Valyl tRNA synthetase tRNA binding arm; Region: Val_tRNA-synt_C; pfam10458
430066006185	Long-chain fatty acid transport protein [Lipid metabolism]; Region: FadL; COG2067
430066006186	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
430066006187	Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497
430066006188	substrate binding pocket [chemical binding]; other site
430066006189	Molybdenum is an essential trace element in the form of molybdenum cofactor (Moco) which is associated with the metabolism of nitrogen, carbon and sulfur by redox active enzymes. In E. coli, the synthesis of Moco involves genes from several loci: moa; Region: MobB; cd03116
430066006190	molybdopterin-guanine dinucleotide biosynthesis protein MobA; Reviewed; Region: mobA; PRK00317
430066006191	MobA catalyzes the formation of molybdopterin guanine dinucleotide; Region: MobA; cd02503
430066006192	GTP binding site; other site
430066006193	molybdenum cofactor biosynthesis protein A; Provisional; Region: PRK13361
430066006194	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
430066006195	FeS/SAM binding site; other site
430066006196	Molybdenum Cofactor Synthesis C; Region: Mob_synth_C; pfam06463
430066006197	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3536
430066006198	2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases [Coenzyme metabolism / Energy production and conversion]; Region: UbiH; COG0654
430066006199	ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314
430066006200	fumarate hydratase; Provisional; Region: PRK15389
430066006201	Fumarate hydratase (Fumerase); Region: Fumerase; pfam05681
430066006202	Fumarase C-terminus; Region: Fumerase_C; pfam05683
430066006203	Transglycosylase associated protein; Region: Transgly_assoc; pfam04226
430066006204	Integrase [DNA replication, recombination, and repair]; Region: XerC; COG0582
430066006205	DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182
430066006206	active site
430066006207	Int/Topo IB signature motif; other site
430066006208	catalytic residues [active]
430066006209	DNA binding site [nucleotide binding]
430066006210	Domain of unknown function (DUF4415); Region: DUF4415; pfam14384
430066006211	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2929
430066006212	Queuine/archaeosine tRNA-ribosyltransferase [Translation, ribosomal structure and biogenesis]; Region: Tgt; COG0343
430066006213	queuine tRNA-ribosyltransferase; Provisional; Region: tgt; cl00409
430066006214	Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340
430066006215	Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586
430066006216	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
430066006217	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013
430066006218	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013
430066006219	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
430066006220	Lysozyme family protein [General function prediction only]; Region: zliS; COG3926
430066006221	Glycosyl hydrolase 108; Region: Glyco_hydro_108; pfam05838
430066006222	Predicted Peptidoglycan domain; Region: PG_binding_3; pfam09374
430066006223	Arsenate Reductase (ArsC) family, ArsC subfamily; arsenic reductases similar to that encoded by arsC on the R733 plasmid of Escherichia coli. E. coli ArsC catalyzes the reduction of arsenate [As(V)] to arsenite [As(III)], the first step in the...; Region: ArsC_ArsC; cd03034
430066006224	ArsC family; Region: ArsC; pfam03960
430066006225	catalytic residues [active]
430066006226	Lipoproteins [Cell envelope biogenesis, outer membrane]; Region: RlpA; COG0797
430066006227	Rare lipoprotein A (RlpA)-like double-psi beta-barrel; Region: DPBB_1; pfam03330
430066006228	Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872
430066006229	D-alanyl-D-alanine carboxypeptidase [Cell envelope biogenesis, outer membrane]; Region: DacC; COG1686
430066006230	Penicillin-binding protein 5, C-terminal domain; Region: PBP5_C; pfam07943
430066006231	Thymidylate kinase [Nucleotide transport and metabolism]; Region: Tmk; COG0125
430066006232	Thymidine monophosphate kinase (TMPK), also known as thymidylate kinase, catalyzes the phosphorylation of thymidine monophosphate (TMP) to thymidine diphosphate (TDP) utilizing ATP as its preferred phophoryl donor. TMPK represents the rate-limiting step...; Region: TMPK; cd01672
430066006233	TMP-binding site; other site
430066006234	ATP-binding site [chemical binding]; other site
430066006235	DNA polymerase III subunit delta'; Validated; Region: PRK09112
430066006236	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189
430066006237	DNA polymerase III subunit delta'; Validated; Region: PRK08485
430066006238	methionyl-tRNA synthetase; Reviewed; Region: PRK11893
430066006239	catalytic core domain of methioninyl-tRNA synthetases; Region: MetRS_core; cd00814
430066006240	active site
430066006241	HIGH motif; other site
430066006242	KMSKS motif; other site
430066006243	Anticodon-binding domain of methionyl tRNA synthetases; Region: Anticodon_Ia_Met; cd07957
430066006244	tRNA binding surface [nucleotide binding]; other site
430066006245	anticodon binding site; other site
430066006246	Predicted metal-dependent hydrolases with the TIM-barrel fold [General function prediction only]; Region: COG1099
430066006247	TatD like proteins;  E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310
430066006248	active site
430066006249	Metal-dependent hydrolases of the beta-lactamase superfamily I [General function prediction only]; Region: PhnP; COG1235
430066006250	putative hydrolase; Provisional; Region: PRK02113
430066006251	cyclic beta-1,2-glucan ABC transporter; Provisional; Region: PRK13657
430066006252	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
430066006253	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
430066006254	Walker A/P-loop; other site
430066006255	ATP binding site [chemical binding]; other site
430066006256	Q-loop/lid; other site
430066006257	ABC transporter signature motif; other site
430066006258	Walker B; other site
430066006259	D-loop; other site
430066006260	H-loop/switch region; other site
430066006261	Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564
430066006262	Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869
430066006263	active site
430066006264	Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697
430066006265	EamA-like transporter family; Region: EamA; pfam00892
430066006266	EamA-like transporter family; Region: EamA; pfam00892
430066006267	Predicted phosphatases [General function prediction only]; Region: Gph; COG0546
430066006268	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cl17915
430066006269	motif I; other site
430066006270	active site
430066006271	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
430066006272	motif II; other site
430066006273	Chaperone required for the assembly of the mitochondrial F1-ATPase [Posttranslational modification, protein turnover, chaperones]; Region: COG5387
430066006274	glutamine synthetase; Provisional; Region: glnA; PRK09469
430066006275	Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951
430066006276	Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120
430066006277	Nitrogen regulatory protein PII [Amino acid transport and metabolism]; Region: GlnK; COG0347
430066006278	Nitrogen regulatory protein P-II; Region: P-II; smart00938
430066006279	Uncharacterized conserved protein [Function unknown]; Region: COG0062
430066006280	B.subtilis YXKO protein of unknown function and related proteins. Based on the conservation of the ATP binding site, the substrate binding site and the Mg2+binding site and structural homology this group is a member of the ribokinase-like superfamily; Region: YXKO-related; cd01171
430066006281	putative substrate binding site [chemical binding]; other site
430066006282	putative ATP binding site [chemical binding]; other site
430066006283	phosphoglycolate phosphatase; Provisional; Region: PRK13222
430066006284	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
430066006285	motif II; other site
430066006286	RPI_A: Ribose 5-phosphate isomerase type A (RPI_A) subfamily; RPI catalyzes the reversible conversion of ribose-5-phosphate to ribulose 5-phosphate, the first step of the non-oxidative branch of the pentose phosphate pathway. This reaction leads to the...; Region: RPI_A; cd01398
430066006287	tetramer (dimer of dimers) interface [polypeptide binding]; other site
430066006288	active site
430066006289	dimer interface [polypeptide binding]; other site
430066006290	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3184
430066006291	glutathione reductase; Validated; Region: PRK06116
430066006292	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
430066006293	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
430066006294	Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852
430066006295	Class-II DAHP synthetase family; Region: DAHP_synth_2; pfam01474
430066006296	Diacylglycerol kinase [Cell envelope biogenesis, outer membrane]; Region: DgkA; COG0818
430066006297	NAD synthetase; Provisional; Region: PRK13981
430066006298	Glutamine aminotransferase (GAT, glutaminase) domain of glutamine-dependent NAD synthetases (class 7 and 8 nitrilases); Region: GAT_Gln-NAD-synth; cd07570
430066006299	multimer interface [polypeptide binding]; other site
430066006300	active site
430066006301	catalytic triad [active]
430066006302	protein interface 1 [polypeptide binding]; other site
430066006303	NAD+ synthase is a homodimer, which catalyzes the final step in de novo nicotinamide adenine dinucleotide (NAD+) biosynthesis, an amide transfer from either ammonia or glutamine to nicotinic acid adenine dinucleotide (NaAD). The conversion of NaAD to NAD...; Region: NAD_synthase; cd00553
430066006304	homodimer interface [polypeptide binding]; other site
430066006305	NAD binding pocket [chemical binding]; other site
430066006306	ATP binding pocket [chemical binding]; other site
430066006307	Mg binding site [ion binding]; other site
430066006308	active-site loop [active]
430066006309	glutamyl-tRNA synthetase; Provisional; Region: PRK12558
430066006310	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
430066006311	active site
430066006312	HIGH motif; other site
430066006313	nucleotide binding site [chemical binding]; other site
430066006314	catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808
430066006315	active site
430066006316	KMSKS motif; other site
430066006317	malic enzyme; Reviewed; Region: PRK12862
430066006318	Malic enzyme, N-terminal domain; Region: malic; pfam00390
430066006319	NAD(P) binding domain of malic enzyme (ME), subgroup 2; Region: NAD_bind_2_malic_enz; cd05311
430066006320	putative NAD(P) binding site [chemical binding]; other site
430066006321	Phosphotransacetylase [Energy production and conversion]; Region: Pta; COG0280
430066006322	L-Ala-D/L-Glu epimerase; Provisional; Region: PRK15129
430066006323	L-Ala-D/L-Glu epimerase catalyzes the epimerization of L-Ala-D/L-Glu and other dipeptides. The genomic context and the substrate specificity of characterized members of this family from E.coli and B.subtilis indicates a possible role in the metabolism of...; Region: L-Ala-DL-Glu_epimerase; cd03319
430066006324	active site
430066006325	Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function; Region: STAS_SulP_like_sulfate_transporter; cd07042
430066006326	ABC-type transport system involved in resistance to organic solvents, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2B; COG0767
430066006327	Permease; Region: Permease; pfam02405
430066006328	ABC-type transport system involved in resistance to organic solvents, ATPase component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2A; COG1127
430066006329	ATP-binding cassette transport system involved in resistant to organic solvents; Region: ABC_Org_Solvent_Resistant; cd03261
430066006330	Walker A/P-loop; other site
430066006331	ATP binding site [chemical binding]; other site
430066006332	Q-loop/lid; other site
430066006333	ABC transporter signature motif; other site
430066006334	Walker B; other site
430066006335	D-loop; other site
430066006336	H-loop/switch region; other site
430066006337	virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996
430066006338	mce related protein; Region: MCE; pfam02470
430066006339	ABC-type uncharacterized transport system, auxiliary component [General function prediction only]; Region: COG3218
430066006340	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3009
430066006341	ABC-type transport system involved in resistance to organic solvents, periplasmic component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2C; COG1463
430066006342	Ferredoxin [Energy production and conversion]; Region: Fdx; COG0633
430066006343	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
430066006344	catalytic loop [active]
430066006345	iron binding site [ion binding]; other site
430066006346	Thioredoxin reductase [Posttranslational modification, protein turnover, chaperones]; Region: TrxB; COG0492
430066006347	Predicted secreted Zn-dependent protease [Posttranslational modification, protein turnover, chaperones]; Region: COG5661
430066006348	DHPS subgroup of Pterin binding enzymes. DHPS (dihydropteroate synthase), a functional homodimer, catalyzes the condensation of p-aminobenzoic acid (pABA) in the de novo biosynthesis of folate, which is an essential cofactor in both nucleic acid and...; Region: DHPS; cd00739
430066006349	dihydropteroate synthase; Region: DHPS; TIGR01496
430066006350	substrate binding pocket [chemical binding]; other site
430066006351	dimer interface [polypeptide binding]; other site
430066006352	inhibitor binding site; inhibition site
430066006353	Dihydroneopterin aldolase (DHNA) and 7,8-dihydroneopterin triphosphate epimerase domain (DHNTPE); these enzymes have been designated folB and folX, respectively. Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and...; Region: DHNA_DHNTPE; cd00534
430066006354	homooctamer interface [polypeptide binding]; other site
430066006355	active site
430066006356	7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase (HPPK). Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and amino acids as well as formyl-tRNA. Mammalian cells are able to utilize pre-formed folates after...; Region: HPPK; cd00483
430066006357	catalytic center binding site [active]
430066006358	ATP binding site [chemical binding]; other site
430066006359	Predicted membrane protein [Function unknown]; Region: COG3768
430066006360	Domain of unknown function (DUF697); Region: DUF697; cl12064
430066006361	YcjX-like family, DUF463; Region: DUF463; cl01193
430066006362	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
430066006363	catalytic core [active]
430066006364	RNA polymerase-binding protein DksA; Region: dksA; TIGR02420
430066006365	Flagellar biosynthesis protein, FliO; Region: FliO; pfam04347
430066006366	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
430066006367	PAS domain; Region: PAS_9; pfam13426
430066006368	putative active site [active]
430066006369	heme pocket [chemical binding]; other site
430066006370	PAS fold; Region: PAS_4; pfam08448
430066006371	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
430066006372	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
430066006373	dimer interface [polypeptide binding]; other site
430066006374	phosphorylation site [posttranslational modification]
430066006375	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
430066006376	ATP binding site [chemical binding]; other site
430066006377	Mg2+ binding site [ion binding]; other site
430066006378	G-X-G motif; other site
430066006379	Response regulator receiver domain; Region: Response_reg; pfam00072
430066006380	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
430066006381	active site
430066006382	phosphorylation site [posttranslational modification]
430066006383	intermolecular recognition site; other site
430066006384	dimerization interface [polypeptide binding]; other site
430066006385	uncharacterized flavoprotein, PP_4765 family; Region: flavo_PP4765; TIGR03862
430066006386	Beta-lactamase; Region: Beta-lactamase; pfam00144
430066006387	Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680
430066006388	Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668
430066006389	Mechanosensitive ion channel; Region: MS_channel; pfam00924
430066006390	ribonucleotide-diphosphate reductase subunit alpha; Validated; Region: PRK07562
430066006391	Class II vitamin B12-dependent ribonucleotide reductase; Region: Ribonuc_red_2_N; pfam08471
430066006392	Ribonucleotide reductase and Pyruvate formate lyase; Region: RNR_PFL; cl09939
430066006393	Class II ribonucleotide reductase, dimeric form; Region: RNR_II_dimer; cd02888
430066006394	active site
430066006395	Ribonucleotide reductase and Pyruvate formate lyase; Region: RNR_PFL; cl09939
430066006396	TSCPD domain; Region: TSCPD; pfam12637
430066006397	Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_9; cd04666
430066006398	nudix motif; other site
430066006399	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
430066006400	active site
430066006401	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
430066006402	Ligand Binding Site [chemical binding]; other site
430066006403	Predicted nucleotide-utilizing enzyme related to molybdopterin-biosynthesis enzyme MoeA [General function prediction only]; Region: CinA; COG1058
430066006404	Competence-damaged protein. CinA is the first gene in the competence- inducible (cin) operon and is thought to be specifically required at some stage in the process of transformation. This domain is closely related to a domain, found in a variety of...; Region: cinA; cd00885
430066006405	putative MPT binding site; other site
430066006406	NAD(P)H:quinone oxidoreductase; Provisional; Region: PRK03767
430066006407	NADPH-dependent FMN reductase; Region: FMN_red; pfam03358
430066006408	threonine dehydratase; Validated; Region: PRK08639
430066006409	Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562
430066006410	tetramer interface [polypeptide binding]; other site
430066006411	pyridoxal 5'-phosphate binding site [chemical binding]; other site
430066006412	catalytic residue [active]
430066006413	Second of two tandem C-terminal ACT domains of threonine dehydratase I (ThrD-I; L-threonine hydrolyase); Region: ACT_ThrD-I_2; cd04907
430066006414	putative Ile/Val binding site [chemical binding]; other site
430066006415	DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker  B motif; Region: DEADc; cd00268
430066006416	DEAD-like helicases superfamily; Region: DEXDc; smart00487
430066006417	ATP binding site [chemical binding]; other site
430066006418	Mg++ binding site [ion binding]; other site
430066006419	motif III; other site
430066006420	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
430066006421	nucleotide binding region [chemical binding]; other site
430066006422	ATP-binding site [chemical binding]; other site
430066006423	Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031
430066006424	CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561
430066006425	dimer interface [polypeptide binding]; other site
430066006426	pyridoxal 5'-phosphate binding site [chemical binding]; other site
430066006427	catalytic residue [active]
430066006428	Predicted metal-dependent hydrolases related to alanyl-tRNA synthetase HxxxH domain [General function prediction only]; Region: COG2872
430066006429	Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; pfam07973
430066006430	Rhodanese-related sulfurtransferase [Inorganic ion transport and metabolism]; Region: SseA; COG2897
430066006431	Thiosulfate sulfurtransferase (TST), N-terminal, inactive domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the 1st repeat, which does not contain the catalytically active Cys residue. The role of the 1st repeat is uncertain, but it...; Region: TST_Repeat_1; cd01448
430066006432	active site residue [active]
430066006433	Thiosulfate sulfurtransferase (TST), C-terminal, catalytic domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the second repeat. Only the second repeat contains the catalytically active Cys residue; Region: TST_Repeat_2; cd01449
430066006434	active site residue [active]
430066006435	Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673
430066006436	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
430066006437	Coenzyme A binding pocket [chemical binding]; other site
430066006438	Acetyl-CoA hydrolase/transferase N-terminal domain; Region: AcetylCoA_hydro; pfam02550
430066006439	succinate CoA transferase; Region: YgfH_subfam; TIGR03458
430066006440	Acetyl-CoA hydrolase/transferase C-terminal domain; Region: AcetylCoA_hyd_C; pfam13336
430066006441	Multidrug resistance efflux pump [Defense mechanisms]; Region: EmrA; COG1566
430066006442	HlyD family secretion protein; Region: HlyD_3; pfam13437
430066006443	Predicted methyltransferase (contains TPR repeat) [General function prediction only]; Region: COG4976
430066006444	Tetratricopeptide repeat; Region: TPR_1; pfam00515
430066006445	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
430066006446	S-adenosylmethionine binding site [chemical binding]; other site
430066006447	Predicted Na+-dependent transporter [General function prediction only]; Region: COG0385
430066006448	SBF-like CPA transporter family (DUF4137); Region: DUF4137; pfam13593
430066006449	UDP-glucose 4-epimerase; Region: PLN02240
430066006450	UDP-glucose 4 epimerase, subgroup 1, extended (e) SDRs; Region: UDP_G4E_1_SDR_e; cd05247
430066006451	NAD binding site [chemical binding]; other site
430066006452	homodimer interface [polypeptide binding]; other site
430066006453	active site
430066006454	substrate binding site [chemical binding]; other site
430066006455	nucleoside triphosphate pyrophosphohydrolase; Reviewed; Region: mazG; PRK09562
430066006456	Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) N-terminal tandem-domain of MazG proteins from Escherichia coli and bacterial homologs; Region: NTP-PPase_MazG_Nterm; cd11528
430066006457	homodimer interface [polypeptide binding]; other site
430066006458	metal binding site [ion binding]; metal-binding site
430066006459	Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) C-terminal tandem-domain of MazG proteins from Escherichia coli and bacterial homologs' Region: NTP-PPase_MazG_Cterm; cd11529
430066006460	homodimer interface [polypeptide binding]; other site
430066006461	active site
430066006462	putative chemical substrate binding site [chemical binding]; other site
430066006463	metal binding site [ion binding]; metal-binding site
430066006464	Conserved protein/domain typically associated with flavoprotein oxygenases, DIM6/NTAB family [General function prediction only]; Region: COG1853
430066006465	Nitroreductase-like family which includes NADH oxidase and arsenite oxidiase. NADH oxidase catalyses the oxidation of NAD(P)H and accepts a wide broad range of compounds as electron acceptors, such as nitrocompound. Arsenite oxidase in a...; Region: Arsenite_oxidase; cd02135
430066006466	putative FMN binding site [chemical binding]; other site
430066006467	threonyl-tRNA synthetase; Reviewed; Region: thrS; PRK00413
430066006468	TGS _ThrRS_N:  ThrRS (threonyl-tRNA Synthetase)  is a class II tRNA synthetase that couples threonine to its cognate tRNA.  In addition to its catalytic and anticodon-binding domains, ThrRS has an N-terminal TGS domain, named after the ThrRS, GTPase, and...; Region: TGS_ThrRS_N; cd01667
430066006469	Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863
430066006470	Threonyl-tRNA synthetase (ThrRS) class II core catalytic domain. ThrRS is a homodimer. It is responsible for the attachment of threonine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ThrRS_core; cd00771
430066006471	active site
430066006472	dimer interface [polypeptide binding]; other site
430066006473	motif 1; other site
430066006474	motif 2; other site
430066006475	motif 3; other site
430066006476	ThrRS Threonyl-anticodon binding domain. ThrRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: ThrRS_anticodon; cd00860
430066006477	anticodon binding site; other site
430066006478	Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872
430066006479	D-alanyl-D-alanine carboxypeptidase; Region: Peptidase_S11; pfam00768
430066006480	Sporulation related domain; Region: SPOR; pfam05036
430066006481	hypothetical protein; Validated; Region: PRK00041
430066006482	NifU homolog involved in Fe-S cluster formation [Energy production and conversion]; Region: IscU; COG0822
430066006483	Iron-sulfur cluster scaffold-like proteins; Region: IscU_like; cd06664
430066006484	trimerization site [polypeptide binding]; other site
430066006485	active site
430066006486	GTP cyclohydrolase I (GTP-CH-I) catalyzes the conversion of GTP into dihydroneopterin triphosphate.  The enzyme product is the precursor of tetrahydrofolate in eubacteria, fungi, and plants and of the folate analogs in methanogenic bacteria.  In...; Region: GTP_cyclohydro1; cd00642
430066006487	homodecamer interface [polypeptide binding]; other site
430066006488	GTP cyclohydrolase I; Provisional; Region: PLN03044
430066006489	active site
430066006490	putative catalytic site residues [active]
430066006491	zinc binding site [ion binding]; other site
430066006492	GTP-CH-I/GFRP interaction surface; other site
430066006493	phosphoribosyl-AMP cyclohydrolase; Reviewed; Region: hisI; PRK00051
430066006494	hypothetical protein; Provisional; Region: PRK10279
430066006495	Bacterial patatin-like phospholipase domain containing protein 6; Region: Pat_NTE_like_bacteria; cd07228
430066006496	nucleophile elbow; other site
430066006497	Integrase [DNA replication, recombination, and repair]; Region: XerC; COG0582
430066006498	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
430066006499	active site
430066006500	DNA binding site [nucleotide binding]
430066006501	Int/Topo IB signature motif; other site
430066006502	Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and...; Region: SR_ResInv; cd03768
430066006503	Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961
430066006504	catalytic residues [active]
430066006505	catalytic nucleophile [active]
430066006506	Presynaptic Site I dimer interface [polypeptide binding]; other site
430066006507	Synaptic Antiparallel dimer interface [polypeptide binding]; other site
430066006508	Synaptic Flat tetramer interface [polypeptide binding]; other site
430066006509	Synaptic Site I dimer interface [polypeptide binding]; other site
430066006510	DNA binding site [nucleotide binding]
430066006511	BRO family, N-terminal domain; Region: Bro-N; smart01040
430066006512	Glutaryl-CoA dehydrogenase; Region: GCD; cd01151
430066006513	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
430066006514	FAD binding site [chemical binding]; other site
430066006515	substrate binding pocket [chemical binding]; other site
430066006516	catalytic base [active]
430066006517	Transcriptional regulator [Transcription]; Region: LysR; COG0583
430066006518	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
430066006519	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
430066006520	dimerization interface [polypeptide binding]; other site
430066006521	luciferase family oxidoreductase, group 1; Region: oxido_grp_1; TIGR03558
430066006522	Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892
430066006523	Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cd00347
430066006524	multidrug efflux protein; Reviewed; Region: PRK09579
430066006525	RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730
430066006526	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
430066006527	HlyD family secretion protein; Region: HlyD_3; pfam13437
430066006528	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
430066006529	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
430066006530	queuine tRNA-ribosyltransferase; Provisional; Region: tgt; PRK00112
430066006531	Queuine/archaeosine tRNA-ribosyltransferase [Translation, ribosomal structure and biogenesis]; Region: Tgt; COG0343
430066006532	S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Provisional; Region: queA; PRK00147
430066006533	S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Region: queA; TIGR00113
430066006534	cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the...; Region: cyclophilin; cd00317
430066006535	active site
430066006536	cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the...; Region: cyclophilin; cd00317
430066006537	active site
430066006538	phosphopantetheine adenylyltransferase; Provisional; Region: coaD; PRK00168
430066006539	Phosphopantetheine adenylyltransferase; Region: PPAT; cd02163
430066006540	active site
430066006541	(T/H)XGH motif; other site
430066006542	DNA gyrase subunit A; Validated; Region: PRK05560
430066006543	DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187
430066006544	CAP-like domain; other site
430066006545	active site
430066006546	primary dimer interface [polypeptide binding]; other site
430066006547	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
430066006548	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
430066006549	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
430066006550	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
430066006551	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
430066006552	Multiple antibiotic transporter [Intracellular trafficking and secretion]; Region: MarC; COG2095
430066006553	Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates...; Region: NK; cl17190
430066006554	phosphonates metabolism transcriptional regulator PhnF; Region: C_P_lyase_phnF; TIGR02325
430066006555	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
430066006556	DNA-binding site [nucleotide binding]; DNA binding site
430066006557	UTRA domain; Region: UTRA; pfam07702
430066006558	Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629
430066006559	SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496
430066006560	dimer interface [polypeptide binding]; other site
430066006561	ssDNA binding site [nucleotide binding]; other site
430066006562	tetramer (dimer of dimers) interface [polypeptide binding]; other site
430066006563	excinuclease ABC subunit A; Reviewed; Region: uvrA; PRK00349
430066006564	ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270
430066006565	ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270
430066006566	ATP-binding cassette domain II of the excision repair protein UvrA; Region: ABC_UvrA_II; cd03271
430066006567	Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591
430066006568	IHF dimer interface [polypeptide binding]; other site
430066006569	IHF - DNA interface [nucleotide binding]; other site
430066006570	ATP-dependent Lon protease, bacterial type [Posttranslational modification, protein turnover, chaperones]; Region: Lon; COG0466
430066006571	Found in ATP-dependent protease La (LON); Region: LON; smart00464
430066006572	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
430066006573	Walker A motif; other site
430066006574	ATP binding site [chemical binding]; other site
430066006575	Walker B motif; other site
430066006576	arginine finger; other site
430066006577	Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362
430066006578	ATP-dependent protease ATP-binding subunit ClpX; Provisional; Region: clpX; PRK05342
430066006579	ClpX C4-type zinc finger; Region: zf-C4_ClpX; pfam06689
430066006580	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
430066006581	Walker A motif; other site
430066006582	ATP binding site [chemical binding]; other site
430066006583	Walker B motif; other site
430066006584	C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086
430066006585	Protease subunit of ATP-dependent Clp proteases [Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: ClpP; COG0740
430066006586	Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017
430066006587	oligomer interface [polypeptide binding]; other site
430066006588	active site residues [active]
430066006589	GTPases [General function prediction only]; Region: HflX; COG2262
430066006590	GTP-binding GTPase N-terminal; Region: GTP-bdg_N; pfam13167
430066006591	HflX GTPase family; Region: HflX; cd01878
430066006592	G1 box; other site
430066006593	GTP/Mg2+ binding site [chemical binding]; other site
430066006594	Switch I region; other site
430066006595	G2 box; other site
430066006596	G3 box; other site
430066006597	Switch II region; other site
430066006598	G4 box; other site
430066006599	G5 box; other site
430066006600	bacterial Hfq-like; Region: Hfq; cd01716
430066006601	hexamer interface [polypeptide binding]; other site
430066006602	Sm1 motif; other site
430066006603	RNA binding site [nucleotide binding]; other site
430066006604	Sm2 motif; other site
430066006605	Capsular polysaccharide synthesis protein; Region: Caps_synth; pfam05704
430066006606	potassium transporter peripheral membrane component; Reviewed; Region: trkA; PRK09496
430066006607	TrkA-N domain; Region: TrkA_N; pfam02254
430066006608	TrkA-C domain; Region: TrkA_C; pfam02080
430066006609	TrkA-N domain; Region: TrkA_N; pfam02254
430066006610	TrkA-C domain; Region: TrkA_C; pfam02080
430066006611	Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204
430066006612	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
430066006613	active site
430066006614	phosphorylation site [posttranslational modification]
430066006615	intermolecular recognition site; other site
430066006616	dimerization interface [polypeptide binding]; other site
430066006617	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
430066006618	Walker A motif; other site
430066006619	ATP binding site [chemical binding]; other site
430066006620	Walker B motif; other site
430066006621	arginine finger; other site
430066006622	Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954
430066006623	Signal transduction histidine kinase involved in nitrogen fixation and metabolism regulation [Signal transduction mechanisms]; Region: NtrY; COG5000
430066006624	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
430066006625	dimerization interface [polypeptide binding]; other site
430066006626	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
430066006627	dimer interface [polypeptide binding]; other site
430066006628	phosphorylation site [posttranslational modification]
430066006629	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
430066006630	ATP binding site [chemical binding]; other site
430066006631	Mg2+ binding site [ion binding]; other site
430066006632	G-X-G motif; other site
430066006633	nitrogen regulation protein NR(I); Region: ntrC; TIGR01818
430066006634	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
430066006635	active site
430066006636	phosphorylation site [posttranslational modification]
430066006637	intermolecular recognition site; other site
430066006638	dimerization interface [polypeptide binding]; other site
430066006639	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
430066006640	Walker A motif; other site
430066006641	ATP binding site [chemical binding]; other site
430066006642	Walker B motif; other site
430066006643	arginine finger; other site
430066006644	Bacterial regulatory protein, Fis family; Region: HTH_8; cl17420
430066006645	Signal transduction histidine kinase, nitrogen specific [Signal transduction mechanisms]; Region: NtrB; COG3852
430066006646	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
430066006647	dimer interface [polypeptide binding]; other site
430066006648	phosphorylation site [posttranslational modification]
430066006649	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
430066006650	ATP binding site [chemical binding]; other site
430066006651	Mg2+ binding site [ion binding]; other site
430066006652	G-X-G motif; other site
430066006653	tRNA-dihydrouridine synthase [Translation, ribosomal structure and biogenesis]; Region: COG0042
430066006654	Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801
430066006655	FMN binding site [chemical binding]; other site
430066006656	active site
430066006657	catalytic residues [active]
430066006658	substrate binding site [chemical binding]; other site
430066006659	bifunctional 2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase/2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase protein; Provisional; Region: ispDF; PRK09382
430066006660	CDP-ME synthetase is involved in mevalonate-independent isoprenoid production; Region: CDP-ME_synthetase; cd02516
430066006661	substrate binding site; other site
430066006662	dimer interface; other site
430066006663	MECDP_synthase (2-C-methyl-D-erythritol-2,4-cyclodiphosphate synthase), encoded by the ispF gene, catalyzes the formation of 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (MEC) in the non-mevalonate deoxyxylulose (DOXP) pathway for isoprenoid biosynthesis; Region: MECDP_synthase; cd00554
430066006664	homotrimer interaction site [polypeptide binding]; other site
430066006665	zinc binding site [ion binding]; other site
430066006666	CDP-binding sites; other site
430066006667	Uncharacterized protein (competence- and mitomycin-induced) [General function prediction only]; Region: CinA; COG1546
430066006668	3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653
430066006669	classical (c) SDRs; Region: SDR_c; cd05233
430066006670	NAD(P) binding site [chemical binding]; other site
430066006671	active site
430066006672	Coenzyme Q-binding protein COQ10p and similar proteins; Region: COQ10p_like; cd07813
430066006673	putative coenzyme Q binding site [chemical binding]; other site
430066006674	lipoyl synthase; Provisional; Region: PRK05481
430066006675	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
430066006676	FeS/SAM binding site; other site
430066006677	dihydrolipoamide dehydrogenase; Reviewed; Region: PRK06416
430066006678	Anaerobic glycerol-3-phosphate dehydrogenase [Amino acid transport and metabolism]; Region: GlpB; cl17730
430066006679	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
430066006680	Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852
430066006681	Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849
430066006682	pyruvate dehydrogenase complex dihydrolipoamide acetyltransferase, long form; Region: PDHac_trf_mito; TIGR01349
430066006683	E3 interaction surface; other site
430066006684	lipoyl attachment site [posttranslational modification]; other site
430066006685	e3 binding domain; Region: E3_binding; pfam02817
430066006686	2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198
430066006687	pyruvate dehydrogenase subunit beta; Provisional; Region: PRK11892
430066006688	Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849
430066006689	E3 interaction surface; other site
430066006690	lipoyl attachment site [posttranslational modification]; other site
430066006691	Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036
430066006692	alpha subunit interface [polypeptide binding]; other site
430066006693	TPP binding site [chemical binding]; other site
430066006694	heterodimer interface [polypeptide binding]; other site
430066006695	Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780
430066006696	pyruvate dehydrogenase E1 component, alpha subunit; Region: PDH_E1_alph_y; TIGR03182
430066006697	Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000
430066006698	tetramer interface [polypeptide binding]; other site
430066006699	TPP-binding site [chemical binding]; other site
430066006700	heterodimer interface [polypeptide binding]; other site
430066006701	phosphorylation loop region [posttranslational modification]
430066006702	Septum formation initiator [Cell division and chromosome partitioning]; Region: COG2919
430066006703	Septum formation initiator; Region: DivIC; pfam04977
430066006704	Methyltransferase domain; Region: Methyltransf_23; pfam13489
430066006705	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
430066006706	S-adenosylmethionine binding site [chemical binding]; other site
430066006707	enolase; Provisional; Region: eno; PRK00077
430066006708	Enolase: Enolases are homodimeric enzymes that catalyse the reversible dehydration of 2-phospho-D-glycerate to phosphoenolpyruvate as part of the glycolytic and gluconeogenesis pathways. The reaction is facilitated by the presence of metal ions; Region: enolase; cd03313
430066006709	dimer interface [polypeptide binding]; other site
430066006710	metal binding site [ion binding]; metal-binding site
430066006711	substrate binding pocket [chemical binding]; other site
430066006712	DAHP synthetase I family; Region: DAHP_synth_1; pfam00793
430066006713	2-dehydro-3-deoxyphosphooctonate aldolase; Provisional; Region: PRK05198
430066006714	CTP synthetase; Validated; Region: pyrG; PRK05380
430066006715	CTP synthetase (CTPs) is a two-domain protein, which consists of an N-terminal synthetase domain and C-terminal glutaminase domain. The enzymes hydrolyze the amide bond of glutamine to ammonia and glutamate at the glutaminase domains and transfer nascent...; Region: CTGs; cd03113
430066006716	Catalytic site [active]
430066006717	active site
430066006718	UTP binding site [chemical binding]; other site
430066006719	Type 1 glutamine amidotransferase (GATase1) domain found in Cytidine Triphosphate Synthetase; Region: GATase1_CTP_Synthase; cd01746
430066006720	active site
430066006721	putative oxyanion hole; other site
430066006722	catalytic triad [active]
430066006723	Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376
430066006724	L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734
430066006725	Preprotein translocase subunit SecG [Intracellular trafficking and secretion]; Region: SecG; COG1314
430066006726	Triosephosphate isomerase (TIM) is a glycolytic enzyme that catalyzes the interconversion of dihydroxyacetone phosphate and D-glyceraldehyde-3-phosphate. The reaction is very efficient and requires neither cofactors nor metal ions. TIM, usually...; Region: TIM; cd00311
430066006727	triosephosphate isomerase; Provisional; Region: PRK14565
430066006728	substrate binding site [chemical binding]; other site
430066006729	dimer interface [polypeptide binding]; other site
430066006730	catalytic triad [active]
430066006731	SurA N-terminal domain; Region: SurA_N_3; cl07813
430066006732	Parvulin-like peptidyl-prolyl isomerase [Posttranslational modification, protein turnover, chaperones]; Region: SurA; COG0760
430066006733	PPIC-type PPIASE domain; Region: Rotamase_2; pfam13145
430066006734	anthranilate phosphoribosyltransferase; Provisional; Region: trpD; PRK00188
430066006735	Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885
430066006736	Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591
430066006737	Indole-3-glycerol phosphate synthase (IGPS); an enzyme in the tryptophan biosynthetic pathway, catalyzing the ring closure reaction of 1-(o-carboxyphenylamino)-1-deoxyribulose-5-phosphate (CdRP) to indole-3-glycerol phosphate (IGP), accompanied by the...; Region: IGPS; cd00331
430066006738	active site
430066006739	ribulose/triose binding site [chemical binding]; other site
430066006740	phosphate binding site [ion binding]; other site
430066006741	substrate (anthranilate) binding pocket [chemical binding]; other site
430066006742	product (indole) binding pocket [chemical binding]; other site
430066006743	MoaC family, prokaryotic and eukaryotic. Members of this family are involved in molybdenum cofactor (Moco) biosynthesis, an essential cofactor of a diverse group of redox enzymes. MoaC, a small hexameric protein, converts, together with MoaA, a guanosine...; Region: MoaC_PE; cd01420
430066006744	trimer interface [polypeptide binding]; other site
430066006745	dimer interface [polypeptide binding]; other site
430066006746	putative active site [active]
430066006747	Molybdopterin biosynthesis enzyme [Coenzyme metabolism]; Region: MoeA; COG0303
430066006748	MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoeA; cd00887
430066006749	dimer interface [polypeptide binding]; other site
430066006750	putative functional site; other site
430066006751	putative MPT binding site; other site
430066006752	LexA repressor; Validated; Region: PRK00215
430066006753	LexA DNA binding domain; Region: LexA_DNA_bind; pfam01726
430066006754	Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529
430066006755	Catalytic site [active]
430066006756	Domain of unknown function (DUF4131); Region: DUF4131; pfam13567
430066006757	Predicted membrane metal-binding protein [General function prediction only]; Region: ComEC; COG0658
430066006758	Competence protein; Region: Competence; pfam03772
430066006759	glutamyl-tRNA synthetase; Reviewed; Region: gltX; PRK01406
430066006760	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
430066006761	active site
430066006762	HIGH motif; other site
430066006763	nucleotide binding site [chemical binding]; other site
430066006764	catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808
430066006765	active site
430066006766	KMSKS motif; other site
430066006767	Escherichia coli (Ec) citrate synthase (CS) GltA_like. CS catalyzes the condensation of acetyl coenzyme A (AcCoA) and oxalacetate (OAA) to form citrate and coenzyme A (CoA), the first step in the citric acid cycle (TCA or Krebs cycle). The overall CS...; Region: EcCS_like; cd06114
430066006768	Citrate synthase [Energy production and conversion]; Region: GltA; COG0372
430066006769	dimer interface [polypeptide binding]; other site
430066006770	active site
430066006771	citrylCoA binding site [chemical binding]; other site
430066006772	NADH binding [chemical binding]; other site
430066006773	cationic pore residues; other site
430066006774	oxalacetate/citrate binding site [chemical binding]; other site
430066006775	coenzyme A binding site [chemical binding]; other site
430066006776	catalytic triad [active]
430066006777	Lipid A disaccharide synthetase [Cell envelope biogenesis, outer membrane]; Region: LpxB; COG0763
430066006778	ipid-A-disaccharide synthase; Provisional; Region: PRK14089
430066006779	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3494
430066006780	Acyl-[acyl carrier protein]; Region: LpxA; COG1043
430066006781	UDP-N-acetylglucosamine O-acyltransferase (UDP-GlcNAc acyltransferase): Proteins in this family catalyze the transfer of (R)-3-hydroxymyristic acid from its acyl carrier protein thioester to UDP-GlcNAc. It is the first enzyme in the lipid A biosynthetic...; Region: LbH_UDP-GlcNAc_AT; cd03351
430066006782	active site
430066006783	FabZ is a 17kD beta-hydroxyacyl-acyl carrier protein (ACP) dehydratase that primarily catalyzes the dehydration of beta-hydroxyacyl-ACP to trans-2-acyl-ACP, the third step in the elongation phase of the bacterial/ plastid, type II, fatty-acid...; Region: FabZ; cd01288
430066006784	UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase; Provisional; Region: lpxD; PRK00892
430066006785	UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase, LpxD; Region: LpxD; pfam04613
430066006786	UDP-3-O-acyl-glucosamine N-acyltransferase (LpxD): The enzyme catalyzes the transfer of 3-hydroxymyristic acid or 3-hydroxy-arachidic acid, depending on the organism, from the acyl carrier protein (ACP) to UDP-3-O-acyl-glucosamine to produce UDP-2; Region: LbH_LpxD; cd03352
430066006787	trimer interface [polypeptide binding]; other site
430066006788	active site
430066006789	UDP-GlcNAc binding site [chemical binding]; other site
430066006790	lipid binding site [chemical binding]; lipid-binding site
430066006791	outer membrane protein assembly complex, YaeT protein; Region: OM_YaeT; TIGR03303
430066006792	POTRA domain, FtsQ-type; Region: POTRA_1; pfam08478
430066006793	Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244
430066006794	Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244
430066006795	Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244
430066006796	Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244
430066006797	Surface antigen; Region: Bac_surface_Ag; pfam01103
430066006798	Predicted membrane-associated Zn-dependent proteases 1 [Cell envelope biogenesis, outer membrane]; Region: COG0750
430066006799	RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163
430066006800	active site
430066006801	PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989
430066006802	protein binding site [polypeptide binding]; other site
430066006803	RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163
430066006804	putative substrate binding region [chemical binding]; other site
430066006805	CDP-diglyceride synthetase [Lipid metabolism]; Region: CdsA; COG0575
430066006806	Cytidylyltransferase family; Region: CTP_transf_1; pfam01148
430066006807	undecaprenyl pyrophosphate synthase; Provisional; Region: PRK14834
430066006808	Cis (Z)-Isoprenyl Diphosphate Synthases (cis-IPPS); homodimers which catalyze the successive 1'-4 condensation of the isopentenyl diphosphate (IPP) molecule to trans,trans-farnesyl diphosphate (FPP) or to cis,trans-FPP to form long-chain polyprenyl...; Region: CIS_IPPS; cl00230
430066006809	catalytic residue [active]
430066006810	putative FPP diphosphate  binding site; other site
430066006811	putative FPP binding hydrophobic cleft; other site
430066006812	dimer interface [polypeptide binding]; other site
430066006813	putative IPP diphosphate binding site; other site
430066006814	ribosome recycling factor; Reviewed; Region: frr; PRK00083
430066006815	Ribosome recycling factor (RRF). Ribosome recycling factor dissociates the posttermination complex, composed of the ribosome, deacylated tRNA, and mRNA, after termination of translation.  Thus ribosomes are "recycled" and ready for another...; Region: RRF; cd00520
430066006816	hinge region; other site
430066006817	UMP kinase (UMPK)-Ec, the microbial/chloroplast uridine monophosphate kinase (uridylate kinase) enzyme that catalyzes UMP phosphorylation and plays a key role in pyrimidine nucleotide biosynthesis; regulation of this process is via feed-back control and...; Region: AAK_UMPK-PyrH-Ec; cd04254
430066006818	putative nucleotide binding site [chemical binding]; other site
430066006819	uridine monophosphate binding site [chemical binding]; other site
430066006820	homohexameric interface [polypeptide binding]; other site
430066006821	elongation factor Ts; Provisional; Region: tsf; PRK09377
430066006822	UBA/TS-N domain; Region: UBA; pfam00627
430066006823	Elongation factor TS; Region: EF_TS; pfam00889
430066006824	Elongation factor TS; Region: EF_TS; pfam00889
430066006825	Ribosomal protein S2 (RPS2), involved in formation of the translation initiation complex, where it might contact the messenger RNA and several components of the ribosome. It has been shown that in Escherichia coli RPS2 is essential for the binding of...; Region: RPS2; cd01425
430066006826	rRNA interaction site [nucleotide binding]; other site
430066006827	S8 interaction site; other site
430066006828	putative laminin-1 binding site; other site
430066006829	Calcium/calmodulin dependent protein kinase II Association; Region: CaMKII_AD; cl17504
430066006830	Domain of unknown function (DUF1849); Region: DUF1849; pfam08904
430066006831	This group of proteins belong to a large family of YjgF/YER057c/UK114-like proteins present in bacteria, archaea, and eukaryotes with no definitive function.  The conserved domain is similar in structure to chorismate mutase but there is no sequence...; Region: YjgF_YER057c_UK114_like_1; cd02199
430066006832	homotrimer interaction site [polypeptide binding]; other site
430066006833	putative active site [active]
430066006834	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3146
430066006835	Protein of unknown function, DUF482; Region: DUF482; pfam04339
430066006836	HINT (histidine triad nucleotide-binding protein) subgroup: Members of this CD belong to the superfamily of histidine triad hydrolases that act on alpha-phosphate of ribonucleotides. This subgroup includes members from all three forms of cellular life; Region: HINT_subgroup; cd01277
430066006837	HIT family signature motif; other site
430066006838	catalytic residue [active]
430066006839	ATP-dependent Clp protease ATP-binding subunit clpA; Region: ClpA; TIGR02639
430066006840	Clp amino terminal domain; Region: Clp_N; pfam02861
430066006841	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
430066006842	Walker A motif; other site
430066006843	ATP binding site [chemical binding]; other site
430066006844	Walker B motif; other site
430066006845	arginine finger; other site
430066006846	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
430066006847	Walker A motif; other site
430066006848	ATP binding site [chemical binding]; other site
430066006849	Walker B motif; other site
430066006850	C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431
430066006851	Uncharacterized conserved protein [Function unknown]; Region: COG2127
430066006852	D-alanyl-D-alanine carboxypeptidase [Cell envelope biogenesis, outer membrane]; Region: DacC; COG1686
430066006853	Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872
430066006854	Sporulation related domain; Region: SPOR; pfam05036
430066006855	Uncharacterized conserved protein [Function unknown]; Region: COG5458
430066006856	Serine dehydratase beta chain; Region: SDH_beta; pfam03315
430066006857	L-serine dehydratase, iron-sulfur-dependent, single chain form; Region: sda_mono; TIGR00720
430066006858	Serine dehydratase alpha chain; Region: SDH_alpha; pfam03313
430066006859	Uncharacterized conserved protein [Function unknown]; Region: COG1434
430066006860	YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259
430066006861	putative active site [active]
430066006862	Predicted membrane protein [Function unknown]; Region: COG3503
430066006863	Predicted acyltransferases [Lipid metabolism]; Region: COG1835
430066006864	Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789
430066006865	Helix-Turn-Helix DNA binding domain of the regulatory protein GnyR; Region: HTH_GnyR; cd04776
430066006866	DNA binding residues [nucleotide binding]
430066006867	putative dimer interface [polypeptide binding]; other site
430066006868	Bacterial protein of unknown function (DUF883); Region: DUF883; cl01888
430066006869	7-cyano-7-deazaguanine reductase; Provisional; Region: PRK13258
430066006870	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3803
430066006871	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
430066006872	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
430066006873	non-specific DNA binding site [nucleotide binding]; other site
430066006874	salt bridge; other site
430066006875	sequence-specific DNA binding site [nucleotide binding]; other site
430066006876	Predicted transcriptional regulator [General function prediction only]; Region: COG3800
430066006877	Domain of unknown function (DUF955); Region: DUF955; pfam06114
430066006878	Predicted transcriptional regulator (DUF2083); Region: DUF2083; pfam09856
430066006879	Acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta) [Lipid metabolism]; Region: COG4799
430066006880	malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682
430066006881	Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; cl17345
430066006882	Acetyl/propionyl-CoA carboxylase, alpha subunit [Lipid metabolism]; Region: COG4770
430066006883	Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289
430066006884	Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786
430066006885	Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878
430066006886	The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850
430066006887	carboxyltransferase (CT) interaction site; other site
430066006888	biotinylation site [posttranslational modification]; other site
430066006889	methylmalonyl-CoA mutase; Reviewed; Region: PRK09426
430066006890	Coenzyme B12-dependent-methylmalonyl coenzyme A (CoA) mutase (MCM) family, Alpha subunit-like subfamily; contains proteins similar to the alpha subunit of Propionbacterium shermanni MCM, as well as human and E. coli MCM. Members of this subfamily contain...; Region: MM_CoA_mutase_alpha_like; cd03679
430066006891	active site
430066006892	substrate binding site [chemical binding]; other site
430066006893	coenzyme B12 binding site [chemical binding]; other site
430066006894	methylmalonyl CoA mutase B12 binding domain. This domain binds to B12 (adenosylcobamide), which initiates the conversion of succinyl CoA and methylmalonyl CoA by forming an adenosyl radical, which then undergoes a rearrangement exchanging a hydrogen atom...; Region: MM_CoA_mut_B12_BD; cd02071
430066006895	B12 binding site [chemical binding]; other site
430066006896	cobalt ligand [ion binding]; other site
430066006897	TRAP transporter, 4TM/12TM fusion protein; Region: TRAP_fused; TIGR02123
430066006898	DctM-like transporters; Region: DctM; pfam06808
430066006899	TRAP-type uncharacterized transport system, periplasmic component [General function prediction only]; Region: Imp; COG2358
430066006900	TRAP transporter solute receptor, TAXI family; Region: TRAP_TAXI; TIGR02122
430066006901	glutamate racemase; Provisional; Region: PRK00865
430066006902	rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: LasT; COG0565
430066006903	SpoU rRNA Methylase family; Region: SpoU_methylase; cl17307
430066006904	intracellular protease, PfpI family; Region: PfpI; TIGR01382
430066006905	Type 1 glutamine amidotransferase (GATase1)-like domain found in a subgroup of proteins similar to PfpI from Pyrococcus furiosus; Region: GATase1_PfpI_1; cd03169
430066006906	conserved cys residue [active]
430066006907	Uncharacterized protein related to arylsulfate sulfotransferase involved in siderophore biosynthesis [General function prediction only]; Region: COG4321
430066006908	isocitrate dehydrogenase; Validated; Region: PRK08299
430066006909	alkaline phosphatase; Provisional; Region: PRK10518
430066006910	Alkaline phosphatase homologues; alkaline phosphatases are non-specific phosphomonoesterases that catalyze the hydrolysis reaction via a phosphoseryl intermediate to produce inorganic phosphate and the corresponding alcohol, optimally at high pH; Region: alkPPc; cd00016
430066006911	dimer interface [polypeptide binding]; other site
430066006912	active site
430066006913	alanyl-tRNA synthetase; Reviewed; Region: alaS; PRK00252
430066006914	Alanyl-tRNA synthetase (AlaRS) class II core catalytic domain. AlaRS is a homodimer. It is responsible for the attachment of alanine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: AlaRS_core; cd00673
430066006915	motif 1; other site
430066006916	active site
430066006917	motif 2; other site
430066006918	motif 3; other site
430066006919	Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863
430066006920	recombinase A; Provisional; Region: recA; PRK09354
430066006921	RecA is a  bacterial enzyme which has roles in homologous recombination, DNA repair, and the induction of the SOS response.  RecA couples ATP hydrolysis to DNA strand exchange; Region: recA; cd00983
430066006922	hexamer interface [polypeptide binding]; other site
430066006923	Walker A motif; other site
430066006924	ATP binding site [chemical binding]; other site
430066006925	Walker B motif; other site
430066006926	putative outer membrane lipoprotein; Provisional; Region: PRK10510
430066006927	Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185
430066006928	ligand binding site [chemical binding]; other site
430066006929	Lytic Transglycosylase (LT)  and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL).  LTs...; Region: LT_GEWL; cd00254
430066006930	N-acetyl-D-glucosamine binding site [chemical binding]; other site
430066006931	catalytic residue [active]
430066006932	recombination factor protein RarA; Reviewed; Region: PRK13342
430066006933	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
430066006934	Walker A motif; other site
430066006935	ATP binding site [chemical binding]; other site
430066006936	Walker B motif; other site
430066006937	arginine finger; other site
430066006938	MgsA AAA+ ATPase C terminal; Region: MgsA_C; pfam12002
430066006939	periplasmic serine protease, Do/DeqQ family; Region: degP_htrA_DO; TIGR02037
430066006940	Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365
430066006941	PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987
430066006942	protein binding site [polypeptide binding]; other site
430066006943	PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987
430066006944	protein binding site [polypeptide binding]; other site
430066006945	50S ribosomal protein L17; Validated; Region: rplQ; PRK05591
430066006946	DNA-directed RNA polymerase subunit alpha; Provisional; Region: PRK05182
430066006947	N-terminal domain of the Alpha subunit of Bacterial RNA polymerase; Region: RNAP_alpha_NTD; cd06928
430066006948	alphaNTD homodimer interface [polypeptide binding]; other site
430066006949	alphaNTD - beta interaction site [polypeptide binding]; other site
430066006950	alphaNTD - beta' interaction site [polypeptide binding]; other site
430066006951	Bacterial RNA polymerase, alpha chain C terminal domain; Region: RNA_pol_A_CTD; pfam03118
430066006952	30S ribosomal protein S11; Validated; Region: PRK05309
430066006953	Ribosomal protein S13 [Translation, ribosomal structure and biogenesis]; Region: RpsM; COG0099
430066006954	30S ribosomal protein S13; Region: bact_S13; TIGR03631
430066006955	adenylate kinase; Reviewed; Region: adk; PRK00279
430066006956	Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for...; Region: ADK; cd01428
430066006957	AMP-binding site [chemical binding]; other site
430066006958	ATP-AMP (Ap5A)-binding site [chemical binding]; other site
430066006959	preprotein translocase subunit SecY; Reviewed; Region: secY; PRK09204
430066006960	SecY translocase; Region: SecY; pfam00344
430066006961	50S ribosomal protein L15; Reviewed; Region: rplO; PRK05592
430066006962	Ribosomal protein L30, which is found in eukaryotes and prokaryotes but not in archaea, is one of the smallest ribosomal proteins with a molecular mass of about 7kDa. L30 binds the 23SrRNA as well as the 5S rRNA and is one of five ribosomal proteins that...; Region: Ribosomal_L30; cd01658
430066006963	23S rRNA binding site [nucleotide binding]; other site
430066006964	30S ribosomal protein S5; Validated; Region: rpsE; PRK00550
430066006965	Ribosomal protein S5, N-terminal domain; Region: Ribosomal_S5; pfam00333
430066006966	Ribosomal protein S5, C-terminal domain; Region: Ribosomal_S5_C; pfam03719
430066006967	Ribosomal L18/L5e:  L18 (L5e) is a ribosomal protein found in the central protuberance (CP) of the large subunit. L18 binds 5S rRNA and induces a conformational change that stimulates the binding of L5 to 5S rRNA. Association of 5S rRNA with 23S rRNA...; Region: Ribosomal_L18_L5e; cd00432
430066006968	5S rRNA interface [nucleotide binding]; other site
430066006969	23S rRNA interface [nucleotide binding]; other site
430066006970	L5 interface [polypeptide binding]; other site
430066006971	50S ribosomal protein L6; Validated; Region: rplF; PRK05498
430066006972	Ribosomal protein L6; Region: Ribosomal_L6; pfam00347
430066006973	Ribosomal protein L6; Region: Ribosomal_L6; pfam00347
430066006974	30S ribosomal protein S8; Validated; Region: rpsH; PRK00136
430066006975	30S ribosomal protein S14; Reviewed; Region: rpsN; PRK08881
430066006976	50S ribosomal protein L5; Validated; Region: rplE; PRK00010
430066006977	Ribosomal protein L5; Region: Ribosomal_L5; pfam00281
430066006978	ribosomal L5P family C-terminus; Region: Ribosomal_L5_C; pfam00673
430066006979	50S ribosomal protein L24; Reviewed; Region: rplX; PRK00004
430066006980	KOW motif of Ribosomal Protein L26; Region: KOW_RPL26; cd06089
430066006981	RNA binding site [nucleotide binding]; other site
430066006982	50S ribosomal protein L14; Validated; Region: rplN; PRK05483
430066006983	30S ribosomal protein S17; Reviewed; Region: rpsQ; PRK05610
430066006984	Ribosomal L29 protein/HIP.  L29 is a protein of the large ribosomal Subunit. A homolog, called heparin/heparan sulfate interacting protein (HIP), has also been identified in mammals.  L29 is located on the surface of the large ribosomal subunit, where it...; Region: Ribosomal_L29_HIP; cd00427
430066006985	23S rRNA interface [nucleotide binding]; other site
430066006986	putative translocon interaction site; other site
430066006987	signal recognition particle (SRP54) interaction site; other site
430066006988	L23 interface [polypeptide binding]; other site
430066006989	trigger factor interaction site; other site
430066006990	Ribosomal_L16_L10e: L16 is an essential protein in the large ribosomal subunit of bacteria, mitochondria, and chloroplasts. Large subunits that lack L16 are defective in peptidyl transferase activity, peptidyl-tRNA hydrolysis activity, association with...; Region: Ribosomal_L16_L10e; cd01433
430066006991	23S rRNA interface [nucleotide binding]; other site
430066006992	5S rRNA interface [nucleotide binding]; other site
430066006993	putative antibiotic binding site [chemical binding]; other site
430066006994	L25 interface [polypeptide binding]; other site
430066006995	L27 interface [polypeptide binding]; other site
430066006996	30S ribosomal protein S3; Reviewed; Region: rpsC; PRK00310
430066006997	K homology RNA-binding (KH) domain of the prokaryotic 30S small ribosomal subunit protein S3. S3  is part of the head region of the 30S ribosomal subunit and is believed to interact with mRNA as it threads its way from the latch into the channel.  The KH...; Region: 30S_S3_KH; cd02412
430066006998	G-X-X-G motif; other site
430066006999	Ribosomal protein S3, C-terminal domain; Region: Ribosomal_S3_C; pfam00189
430066007000	Ribosomal protein L22/L17e.  L22 (L17 in eukaryotes) is a core protein of the large ribosomal subunit.  It is the only ribosomal protein that interacts with all six domains of 23S rRNA, and is one of the proteins important for directing the proper...; Region: Ribosomal_L22; cd00336
430066007001	putative translocon binding site; other site
430066007002	protein-rRNA interface [nucleotide binding]; other site
430066007003	30S ribosomal protein S19; Reviewed; Region: rpsS; PRK00357
430066007004	50S ribosomal protein L2; Validated; Region: rplB; PRK09374
430066007005	Ribosomal Proteins L2, RNA binding domain; Region: Ribosomal_L2; pfam00181
430066007006	Ribosomal Proteins L2, C-terminal domain; Region: Ribosomal_L2_C; pfam03947
430066007007	50S ribosomal protein L23; Reviewed; Region: rplW; PRK05738
430066007008	50S ribosomal protein L4; Provisional; Region: rplD; PRK05319
430066007009	50S ribosomal protein L3; Validated; Region: rplC; PRK00001
430066007010	30S ribosomal protein S10; Reviewed; Region: rpsJ; PRK00596
430066007011	elongation factor Tu; Reviewed; Region: PRK00049
430066007012	Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884
430066007013	G1 box; other site
430066007014	GEF interaction site [polypeptide binding]; other site
430066007015	GTP/Mg2+ binding site [chemical binding]; other site
430066007016	Switch I region; other site
430066007017	G2 box; other site
430066007018	G3 box; other site
430066007019	Switch II region; other site
430066007020	G4 box; other site
430066007021	G5 box; other site
430066007022	EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697
430066007023	Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707
430066007024	Antibiotic Binding Site [chemical binding]; other site
430066007025	elongation factor G; Reviewed; Region: PRK00007
430066007026	Elongation factor G (EF-G) family involved in both the elongation and ribosome recycling phases of protein synthesis; Region: EF-G; cd01886
430066007027	G1 box; other site
430066007028	putative GEF interaction site [polypeptide binding]; other site
430066007029	GTP/Mg2+ binding site [chemical binding]; other site
430066007030	Switch I region; other site
430066007031	G2 box; other site
430066007032	G3 box; other site
430066007033	Switch II region; other site
430066007034	G4 box; other site
430066007035	G5 box; other site
430066007036	EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088
430066007037	EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434
430066007038	EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G.  Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713
430066007039	30S ribosomal protein S7; Validated; Region: PRK05302
430066007040	S12-like family, 30S ribosomal protein S12 subfamily; S12 is located at the interface of the large and small ribosomal subunits of prokaryotes, chloroplasts and mitochondria, where it plays an important role in both tRNA and ribosomal subunit...; Region: Ribosomal_S12; cd03368
430066007041	S17 interaction site [polypeptide binding]; other site
430066007042	S8 interaction site; other site
430066007043	16S rRNA interaction site [nucleotide binding]; other site
430066007044	streptomycin interaction site [chemical binding]; other site
430066007045	23S rRNA interaction site [nucleotide binding]; other site
430066007046	aminoacyl-tRNA interaction site (A-site) [nucleotide binding]; other site
430066007047	RNA polymerase Rpb1, domain 1; Region: RNA_pol_Rpb1_1; pfam04997
430066007048	DNA-directed RNA polymerase, beta' subunit/160 kD subunit [Transcription]; Region: RpoC; COG0086
430066007049	RNA polymerase I subunit A N-terminus; Region: RPOLA_N; smart00663
430066007050	RNA polymerase Rpb1, domain 3; Region: RNA_pol_Rpb1_3; pfam04983
430066007051	RNA polymerase Rpb1, domain 4; Region: RNA_pol_Rpb1_4; pfam05000
430066007052	RNA polymerase Rpb1, domain 5; Region: RNA_pol_Rpb1_5; pfam04998
430066007053	Largest subunit of RNA polymerase (RNAP), C-terminal domain; Region: RNAP_largest_subunit_C; cl11429
430066007054	Rpb1 - Rpb6 interaction site [polypeptide binding]; other site
430066007055	Largest subunit of RNA polymerase (RNAP), C-terminal domain; Region: RNAP_largest_subunit_C; cl11429
430066007056	Largest subunit (beta') of Bacterial DNA-dependent RNA polymerase (RNAP), C-terminal domain; Region: RNAP_beta'_C; cd02655
430066007057	DNA binding site [nucleotide binding]
430066007058	Rpb1 (beta') - Rpb2 (beta) interaction site [polypeptide binding]; other site
430066007059	DNA-directed RNA polymerase subunit beta; Reviewed; Region: rpoB; PRK00405
430066007060	RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cl17585
430066007061	RNA polymerase Rpb2, domain 2; Region: RNA_pol_Rpb2_2; pfam04561
430066007062	RNA polymerase Rpb2, domain 2; Region: RNA_pol_Rpb2_2; pfam04561
430066007063	RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653
430066007064	RPB11 interaction site [polypeptide binding]; other site
430066007065	RPB12 interaction site [polypeptide binding]; other site
430066007066	RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653
430066007067	RPB1 interaction site [polypeptide binding]; other site
430066007068	RPB11 interaction site [polypeptide binding]; other site
430066007069	RPB10 interaction site [polypeptide binding]; other site
430066007070	RPB3 interaction site [polypeptide binding]; other site
430066007071	Ribosomal protein L7/L12. Ribosomal protein L7/L12 refers to the large ribosomal subunit proteins L7 and L12, which are identical except that L7 is acetylated at the N terminus. It is a component of the L7/L12 stalk, which is located at the surface of...; Region: Ribosomal_L7_L12; cd00387
430066007072	L11 interface [polypeptide binding]; other site
430066007073	putative EF-Tu interaction site [polypeptide binding]; other site
430066007074	putative EF-G interaction site [polypeptide binding]; other site
430066007075	Ribosomal protein L10 family, L10 subfamily; composed of bacterial 50S ribosomal protein and eukaryotic mitochondrial 39S ribosomal protein, L10. L10 occupies the L7/L12 stalk of the ribosome. The N-terminal domain (NTD) of L10 interacts with L11 protein...; Region: Ribosomal_L10; cd05797
430066007076	23S rRNA interface [nucleotide binding]; other site
430066007077	Interface with L7/L12 ribosomal proteins [polypeptide binding]; other site
430066007078	Ribosomal protein L1.  The L1 protein, located near the E-site of the ribosome, forms part of the L1 stalk along with 23S rRNA.  In bacteria and archaea, L1 functions both as a ribosomal protein that binds rRNA, and as a translation repressor that binds...; Region: Ribosomal_L1; cd00403
430066007079	mRNA/rRNA interface [nucleotide binding]; other site
430066007080	50S ribosomal protein L11; Validated; Region: rplK; PRK00140
430066007081	Ribosomal protein L11. Ribosomal protein L11, together with proteins L10 and L7/L12, and 23S rRNA, form the L7/L12 stalk on the surface of the large subunit of the ribosome. The homologous eukaryotic cytoplasmic protein is also called 60S ribosomal...; Region: Ribosomal_L11; cd00349
430066007082	23S rRNA interface [nucleotide binding]; other site
430066007083	L7/L12 interface [polypeptide binding]; other site
430066007084	putative thiostrepton binding site; other site
430066007085	L25 interface [polypeptide binding]; other site
430066007086	transcription antitermination protein NusG; Validated; Region: nusG; PRK05609
430066007087	Bacterial N-Utilization Substance G (NusG) N-terminal (NGN) domain, subgroup 1; Region: NGN_Bact_1; cd09891
430066007088	putative homodimer interface [polypeptide binding]; other site
430066007089	NusG contains an NGN domain at its N-terminus and KOW motif at its C-terminus; Region: KOW_NusG; cd06091
430066007090	heterodimer interface [polypeptide binding]; other site
430066007091	homodimer interface [polypeptide binding]; other site
430066007092	preprotein translocase subunit SecE; Reviewed; Region: secE; PRK07597
430066007093	elongation factor Tu; Reviewed; Region: PRK00049
430066007094	Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884
430066007095	G1 box; other site
430066007096	GEF interaction site [polypeptide binding]; other site
430066007097	GTP/Mg2+ binding site [chemical binding]; other site
430066007098	Switch I region; other site
430066007099	G2 box; other site
430066007100	G3 box; other site
430066007101	Switch II region; other site
430066007102	G4 box; other site
430066007103	G5 box; other site
430066007104	EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697
430066007105	Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707
430066007106	Antibiotic Binding Site [chemical binding]; other site
430066007107	rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566
430066007108	RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; smart00967
430066007109	SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588
430066007110	FOG: CBS domain [General function prediction only]; Region: COG0517
430066007111	The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair_10; cd04623
430066007112	Membrane associated serine protease [Amino acid transport and metabolism]; Region: COG0705
430066007113	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5388
430066007114	PAS domain; Region: PAS_5; pfam07310
430066007115	Bacterial transglutaminase-like cysteine proteinase BTLCP; Region: BTLCP; pfam06035
430066007116	Carbonic anhydrases/acetyltransferases, isoleucine patch superfamily [General function prediction only]; Region: PaaY; COG0663
430066007117	Gamma carbonic anhydrase-like: This family is composed of gamma carbonic anhydrase (CA), Ferripyochelin Binding Protein (FBP), E. coli paaY protein, and similar proteins. CAs are zinc-containing enzymes that catalyze the reversible hydration of carbon...; Region: LbH_gamma_CA_like; cd04645
430066007118	trimer interface [polypeptide binding]; other site
430066007119	putative metal binding site [ion binding]; other site
430066007120	Protein of unknown function (DUF3126); Region: DUF3126; pfam11324
430066007121	serine acetyltransferase; Provisional; Region: cysE; PRK11132
430066007122	Serine acetyltransferase, N-terminal; Region: SATase_N; smart00971
430066007123	Serine acetyltransferase (SAT): SAT catalyzes the CoA-dependent acetylation of the side chain hydroxyl group of L-serine to form O-acetylserine, as the first step of a two-step biosynthetic pathway in bacteria and plants leading to the formation of...; Region: LbH_SAT; cd03354
430066007124	trimer interface [polypeptide binding]; other site
430066007125	active site
430066007126	substrate binding site [chemical binding]; other site
430066007127	CoA binding site [chemical binding]; other site
430066007128	Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596
430066007129	Putative lysophospholipase; Region: Hydrolase_4; pfam12146
430066007130	Uncharacterized conserved protein [Function unknown]; Region: COG1430
430066007131	Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea.  CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458
430066007132	DNA-binding site [nucleotide binding]; DNA binding site
430066007133	RNA-binding motif; other site
430066007134	Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea.  CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458
430066007135	DNA-binding site [nucleotide binding]; DNA binding site
430066007136	RNA-binding motif; other site
430066007137	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
430066007138	Glyoxalase I catalyzes the isomerization of the hemithioacetal, formed by a 2-oxoaldehyde and glutathione, to S-D-lactoylglutathione; Region: Glyoxalase_I; cd07233
430066007139	dimer interface [polypeptide binding]; other site
430066007140	active site
430066007141	metal binding site [ion binding]; metal-binding site
430066007142	glutathione binding site [chemical binding]; other site
430066007143	single-stranded-DNA-specific exonuclease RecJ; Region: recJ; TIGR00644
430066007144	DHH family; Region: DHH; pfam01368
430066007145	D-alanyl-alanine synthetase A; Reviewed; Region: ddl; PRK01966
430066007146	D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820
430066007147	ATP-grasp domain; Region: ATP-grasp_4; cl17255
430066007148	Bacterial fructose-1,6-bisphosphatase, glpX-encoded; Region: FBPase_glpX; pfam03320
430066007149	Bacterial fructose-1,6-bisphosphatase, glpX-encoded. A dimeric enzyme dependent on Mg(2+). glpX-encoded FPBase (FBPase class II) differs from other members of the inositol-phosphatase superfamily by permutation of secondary structure elements. The core...; Region: FBPase_glpX; cd01516
430066007150	putative active site [active]
430066007151	homoserine dehydrogenase; Provisional; Region: PRK06349
430066007152	Homoserine dehydrogenase, NAD binding domain; Region: NAD_binding_3; pfam03447
430066007153	Homoserine dehydrogenase; Region: Homoserine_dh; pfam00742
430066007154	ACT_HSDH_Hom CD includes the C-terminal ACT domain of the NAD(P)H-dependent, homoserine dehydrogenase (HSDH) and related domains; Region: ACT_HSDH-Hom; cd04881
430066007155	aminotransferase; Validated; Region: PRK09148
430066007156	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
430066007157	pyridoxal 5'-phosphate binding site [chemical binding]; other site
430066007158	homodimer interface [polypeptide binding]; other site
430066007159	catalytic residue [active]
430066007160	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3108
430066007161	Peptidase M15; Region: Peptidase_M15_3; cl01194
430066007162	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3553
430066007163	putative DNA-binding transcriptional regulator; Reviewed; Region: PRK00347
430066007164	Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086
430066007165	active site
430066007166	DNA repair proteins [DNA replication, recombination, and repair]; Region: RadC; COG2003
430066007167	Mov34/MPN/PAD-1 family; Region: MPN_DUF2466; cd08071
430066007168	MPN+ (JAMM) motif; other site
430066007169	Zinc-binding site [ion binding]; other site
430066007170	Opacity protein and related surface antigens [Cell envelope biogenesis, outer membrane]; Region: COG3637
430066007171	Precorrin-6Y methyltransferase, the cobalamin biosynthesis enzyme CbiE; Region: Precorrin-6Y-methylase; cd11644
430066007172	active site
430066007173	SAM binding site [chemical binding]; other site
430066007174	putative homodimer interface [polypeptide binding]; other site
430066007175	Precorrin-6B methylase 2 [Coenzyme metabolism]; Region: CobL; COG2242
430066007176	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
430066007177	S-adenosylmethionine binding site [chemical binding]; other site
430066007178	precorrin-3B synthase; Region: CobG; TIGR02435
430066007179	Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460
430066007180	precorrin-8X methylmutase; Reviewed; Region: cobH; PRK08285
430066007181	Precorrin-8X methylmutase; Region: CbiC; pfam02570
430066007182	Precorrin-2 C20-methyltransferase, also named CobI or CbiL; Region: Precorrin_2_C20_MT; cd11645
430066007183	active site
430066007184	SAM binding site [chemical binding]; other site
430066007185	homodimer interface [polypeptide binding]; other site
430066007186	Cobalamin biosynthesis protein CbiG [Coenzyme metabolism]; Region: CbiG; COG2073
430066007187	Cobalamin synthesis G N-terminal; Region: CbiG_N; pfam11760
430066007188	Cobalamin biosynthesis central region; Region: CbiG_mid; pfam11761
430066007189	Precorrin-3B C(17)-methyltransferase (CobJ/CbiH); Region: Precorrin_3B_C17_MT; cd11646
430066007190	active site
430066007191	SAM binding site [chemical binding]; other site
430066007192	homodimer interface [polypeptide binding]; other site
430066007193	Dipeptidyl aminopeptidases/acylaminoacyl-peptidases [Amino acid transport and metabolism]; Region: DAP2; COG1506
430066007194	ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683
430066007195	Periplasmic binding domain of ATP-binding cassette transporter-like systems that belong to the type I periplasmic binding fold protein superfamily; Region: PBP1_ABC_transporter_LIVBP_like; cd06268
430066007196	ligand binding site [chemical binding]; other site
430066007197	Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011
430066007198	cobalamin biosynthesis protein; Provisional; Region: cobD; PRK01209
430066007199	L-threonine-O-3-phosphate decarboxylase; Region: L_thr_O3P_dcar; TIGR01140
430066007200	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
430066007201	pyridoxal 5'-phosphate binding site [chemical binding]; other site
430066007202	homodimer interface [polypeptide binding]; other site
430066007203	catalytic residue [active]
430066007204	cobyrinic acid a,c-diamide synthase; Validated; Region: PRK01077
430066007205	The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203
430066007206	Type 1 glutamine amidotransferase (GATase1) domain found in Cobyrinic Acid a,c-Diamide Synthase; Region: GATase1_CobB; cd03130
430066007207	Uroporphyrin-III C-methyltransferase (S-Adenosyl-L-methionine:uroporphyrinogen III methyltransferase, SUMT); Region: SUMT; cd11642
430066007208	active site
430066007209	SAM binding site [chemical binding]; other site
430066007210	homodimer interface [polypeptide binding]; other site
430066007211	cobalt-precorrin-6A synthase; Reviewed; Region: cbiD; PRK00075
430066007212	cobalt-precorrin-6x reductase; Reviewed; Region: PRK08057
430066007213	Precorrin-4 C11-methyltransferase (CbiF/CobM); Region: Precorrin-4_C11-MT; cd11641
430066007214	active site
430066007215	SAM binding site [chemical binding]; other site
430066007216	homodimer interface [polypeptide binding]; other site
430066007217	Cobalamin biosynthesis protein CbiG [Coenzyme metabolism]; Region: CbiG; COG2073
430066007218	Cobalamin synthesis G C-terminus; Region: CbiG_C; pfam01890
430066007219	tellurium resistance terB-like protein; Region: terB_like; cd07177
430066007220	metal binding site [ion binding]; metal-binding site
430066007221	hypothetical protein; Provisional; Region: PRK10621
430066007222	Sulfite exporter TauE/SafE; Region: TauE; pfam01925
430066007223	Predicted membrane protein [Function unknown]; Region: COG2510
430066007224	ATP:corrinoid adenosyltransferase [Coenzyme metabolism]; Region: BtuR; COG2109
430066007225	ATP:corrinoid adenosyltransferase BtuR/CobO/CobP. This family consists of the BtuR, CobO, CobP proteins all of which are Cob(I)alamin (vitamin B12) adenosyltransferase, which is involved in cobalamin (vitamin B12) biosynthesis. This enzyme is a homodimer; Region: CobA_CobO_BtuR; cd00561
430066007226	homodimer interface [polypeptide binding]; other site
430066007227	Walker A motif; other site
430066007228	ATP binding site [chemical binding]; other site
430066007229	hydroxycobalamin binding site [chemical binding]; other site
430066007230	Walker B motif; other site
430066007231	cobaltochelatase subunit CobN; Reviewed; Region: cobN; PRK05989
430066007232	CobN subunit of cobaltochelatase, bchH and chlH subunits of magnesium chelatases, and similar proteins; Region: CobN_like; cd10150
430066007233	CobN subunit of cobaltochelatase, bchH and chlH subunits of magnesium chelatases, and similar proteins; Region: CobN_like; cd10150
430066007234	cobalamin biosynthesis protein CobW; Region: CobW; TIGR02475
430066007235	CobW/HypB/UreG, nucleotide-binding domain; Region: cobW; pfam02492
430066007236	Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; pfam07683
430066007237	Adenosylcobinamide kinase / adenosylcobinamide phosphate guanyltransferase (CobU). CobU is bifunctional cobalbumin biosynthesis enzymes which display adenosylcobinamide kinase and adenosylcobinamide phosphate guanyltransferase activity. This enzyme is a...; Region: CobU; cd00544
430066007238	homotrimer interface [polypeptide binding]; other site
430066007239	Walker A motif; other site
430066007240	GTP binding site [chemical binding]; other site
430066007241	Walker B motif; other site
430066007242	Predicted integral membrane protein [Function unknown]; Region: COG5446
430066007243	cobalt transporter subunit CbtB (proposed); Region: CbtB; TIGR02459
430066007244	cobyric acid synthase; Provisional; Region: PRK00784
430066007245	The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203
430066007246	The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203
430066007247	Type 1 glutamine amidotransferase (GATase1) domain found in Cobyric Acid Synthase (CobQ); Region: GATase1_CobQ; cd01750
430066007248	catalytic triad [active]
430066007249	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
430066007250	Isobutyryl-CoA dehydrogenase; Region: IBD; cd01162
430066007251	substrate binding pocket [chemical binding]; other site
430066007252	FAD binding site [chemical binding]; other site
430066007253	catalytic base [active]
430066007254	6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599
430066007255	3-hydroxyisobutyrate dehydrogenase; Region: HIBADH; TIGR01692
430066007256	Transcriptional regulator [Transcription]; Region: LysR; COG0583
430066007257	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
430066007258	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
430066007259	dimerization interface [polypeptide binding]; other site
430066007260	Transcriptional regulator containing an amidase domain and an AraC-type DNA-binding HTH domain [Transcription]; Region: COG4977
430066007261	AraC transcriptional regulators having an N-terminal Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GATase1_AraC_ArgR_like; cd03136
430066007262	conserved cys residue [active]
430066007263	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
430066007264	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
430066007265	Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: COG3264
430066007266	Mechanosensitive ion channel; Region: MS_channel; pfam00924
430066007267	SecD/SecF GG Motif; Region: Sec_GG; pfam07549
430066007268	bifunctional preprotein translocase subunit SecD/SecF; Reviewed; Region: PRK13024
430066007269	protein-export membrane protein, SecD/SecF family; Region: 2A0604s01; TIGR00916
430066007270	SecD/SecF GG Motif; Region: Sec_GG; pfam07549
430066007271	Protein export membrane protein; Region: SecD_SecF; pfam02355
430066007272	putative cation:proton antiport protein; Provisional; Region: PRK10669
430066007273	Kef-type K+ transport system, predicted NAD-binding component [Inorganic ion transport and metabolism]; Region: RosB; COG4651
430066007274	TrkA-N domain; Region: TrkA_N; pfam02254
430066007275	Predicted integral membrane protein [Function unknown]; Region: COG0392
430066007276	sulfate transport protein; Provisional; Region: cysT; CHL00187
430066007277	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
430066007278	dimer interface [polypeptide binding]; other site
430066007279	conserved gate region; other site
430066007280	putative PBP binding loops; other site
430066007281	ABC-ATPase subunit interface; other site
430066007282	ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555
430066007283	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
430066007284	dimer interface [polypeptide binding]; other site
430066007285	conserved gate region; other site
430066007286	putative PBP binding loops; other site
430066007287	ABC-ATPase subunit interface; other site
430066007288	ABC-type sulfate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: CysP; COG4150
430066007289	Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531
430066007290	Membrane protein TerC, possibly involved in tellurium resistance [Inorganic ion transport and metabolism]; Region: TerC; COG0861
430066007291	Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253
430066007292	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590
430066007293	Transporter associated domain; Region: CorC_HlyC; smart01091
430066007294	Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586
430066007295	EF-hand domain pair; Region: EF_hand_5; pfam13499
430066007296	EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to...; Region: EFh; cl17302
430066007297	Ca2+ binding site [ion binding]; other site
430066007298	EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to...; Region: EFh; cl17302
430066007299	Ca2+ binding site [ion binding]; other site
430066007300	Fucose dissimilation pathway protein FucU [Carbohydrate transport and metabolism]; Region: FucU; COG4154
430066007301	short chain dehydrogenase; Provisional; Region: PRK06198
430066007302	classical (c) SDRs; Region: SDR_c; cd05233
430066007303	NAD(P) binding site [chemical binding]; other site
430066007304	active site
430066007305	ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126
430066007306	First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216
430066007307	Walker A/P-loop; other site
430066007308	ATP binding site [chemical binding]; other site
430066007309	Q-loop/lid; other site
430066007310	ABC transporter signature motif; other site
430066007311	Walker B; other site
430066007312	D-loop; other site
430066007313	H-loop/switch region; other site
430066007314	Periplasmic sugar-binding domain of uncharacterized ABC-type transport systems; Region: PBP1_ABC_sugar_binding_like_4; cd06312
430066007315	Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407
430066007316	putative ligand binding site [chemical binding]; other site
430066007317	Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673
430066007318	Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408
430066007319	Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894
430066007320	ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120
430066007321	ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214
430066007322	Walker A/P-loop; other site
430066007323	ATP binding site [chemical binding]; other site
430066007324	Q-loop/lid; other site
430066007325	ABC transporter signature motif; other site
430066007326	Walker B; other site
430066007327	D-loop; other site
430066007328	H-loop/switch region; other site
430066007329	iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577
430066007330	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550
430066007331	ABC-ATPase subunit  interface; other site
430066007332	dimer interface [polypeptide binding]; other site
430066007333	putative PBP binding regions; other site
430066007334	Periplasmic binding protein; Region: Peripla_BP_2; pfam01497
430066007335	Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+.  Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262
430066007336	intersubunit interface [polypeptide binding]; other site
430066007337	Outer membrane cobalamin receptor protein [Coenzyme metabolism]; Region: BtuB; COG4206
430066007338	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
430066007339	N-terminal plug; other site
430066007340	ligand-binding site [chemical binding]; other site
430066007341	ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842
430066007342	ABC-2 type transporter; Region: ABC2_membrane; pfam01061
430066007343	ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842
430066007344	ABC-2 family transporter protein; Region: ABC2_membrane_2; pfam12679
430066007345	ABC-type Mn/Zn transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: ZnuC; COG1121
430066007346	ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230
430066007347	Walker A/P-loop; other site
430066007348	ATP binding site [chemical binding]; other site
430066007349	Q-loop/lid; other site
430066007350	ABC transporter signature motif; other site
430066007351	Walker B; other site
430066007352	D-loop; other site
430066007353	H-loop/switch region; other site
430066007354	ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131
430066007355	ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230
430066007356	Walker A/P-loop; other site
430066007357	ATP binding site [chemical binding]; other site
430066007358	Q-loop/lid; other site
430066007359	ABC transporter signature motif; other site
430066007360	Walker B; other site
430066007361	D-loop; other site
430066007362	H-loop/switch region; other site
430066007363	ABC-2 family transporter protein; Region: ABC2_membrane_3; pfam12698
430066007364	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
430066007365	HlyD family secretion protein; Region: HlyD_3; pfam13437
430066007366	Uncharacterized BCR, COG1649; Region: DUF187; pfam02638
430066007367	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1649
430066007368	Urease gamma-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, archaea, fungi and plants. Their primary role is to allow the use...; Region: Urease_gamma; cd00390
430066007369	alpha-gamma subunit interface [polypeptide binding]; other site
430066007370	beta-gamma subunit interface [polypeptide binding]; other site
430066007371	Urease beta-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, archaea, fungi and plants. Their primary role is to allow the use of...; Region: Urease_beta; cd00407
430066007372	alpha-beta subunit interface [polypeptide binding]; other site
430066007373	urease subunit alpha; Reviewed; Region: ureC; PRK13309
430066007374	Urease alpha-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, fungi and plants. Their primary role is to allow the use of...; Region: Urease_alpha; cd00375
430066007375	subunit interactions [polypeptide binding]; other site
430066007376	active site
430066007377	flap region; other site
430066007378	urease accessory protein UreE; Provisional; Region: ureE; PRK14711
430066007379	UreE urease accessory protein. UreE is a metallochaperone assisting the insertion of a Ni2+ ion in the active site of urease, an important step in the in vivo assembly of urease, an enzyme that hydrolyses urea into ammonia and carbamic acid. The...; Region: UreE; cd00571
430066007380	dimer interface [polypeptide binding]; other site
430066007381	catalytic residues [active]
430066007382	Urease accessory protein UreF [Posttranslational modification, protein turnover, chaperones]; Region: UreF; COG0830
430066007383	UreF; Region: UreF; pfam01730
430066007384	The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203
430066007385	Urease accessory protein UreH [Posttranslational modification, protein turnover, chaperones]; Region: UreH; COG0829
430066007386	Urea transporter [Amino acid transport and metabolism]; Region: Utp; COG4413
430066007387	ABC-type Co2+ transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: CbiK; COG5266
430066007388	cobalt transport protein CbiM; Validated; Region: PRK06265
430066007389	Cobalt uptake substrate-specific transmembrane region; Region: CbiM; pfam01891
430066007390	cobalt ABC transporter, permease protein CbiQ; Region: CbiQ_TIGR; TIGR02454
430066007391	ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122
430066007392	First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225
430066007393	Walker A/P-loop; other site
430066007394	ATP binding site [chemical binding]; other site
430066007395	Q-loop/lid; other site
430066007396	ABC transporter signature motif; other site
430066007397	Walker B; other site
430066007398	D-loop; other site
430066007399	H-loop/switch region; other site
430066007400	camphor resistance protein CrcB; Provisional; Region: ccrB; PRK01636
430066007401	Uncharacterized conserved protein [Function unknown]; Region: COG3439
430066007402	Integral membrane protein possibly involved in chromosome condensation [Cell division and chromosome partitioning]; Region: CrcB; COG0239
430066007403	Predicted flavin-nucleotide-binding protein [General function prediction only]; Region: COG3467
430066007404	Predicted epimerase, PhzC/PhzF homolog [General function prediction only]; Region: COG0384
430066007405	Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447
430066007406	nudix motif; other site
430066007407	Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490
430066007408	putative catalytic site [active]
430066007409	putative metal binding site [ion binding]; other site
430066007410	putative phosphate binding site [ion binding]; other site
430066007411	Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490
430066007412	putative metal binding site [ion binding]; other site
430066007413	BA14K-like protein; Region: BA14K; pfam07886
430066007414	Aspartate/tyrosine/aromatic aminotransferase [Amino acid transport and metabolism]; Region: COG0436
430066007415	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
430066007416	pyridoxal 5'-phosphate binding site [chemical binding]; other site
430066007417	homodimer interface [polypeptide binding]; other site
430066007418	catalytic residue [active]
430066007419	ketol-acid reductoisomerase; Provisional; Region: PRK05479
430066007420	Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvN; pfam07991
430066007421	Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvC; pfam01450
430066007422	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
430066007423	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
430066007424	K+ transporter [Inorganic ion transport and metabolism]; Region: Kup; COG3158
430066007425	potassium uptake protein; Region: kup; TIGR00794
430066007426	Pyridoxine 5'-phosphate (PNP) synthase domain; pyridoxal 5'-phosphate is the active form of vitamin B6 that acts as an essential, ubiquitous coenzyme in amino acid metabolism. In bacteria, formation of pyridoxine 5'-phosphate is a step in...; Region: PNPsynthase; cd00003
430066007427	active site
430066007428	hydrophilic channel; other site
430066007429	dimerization interface [polypeptide binding]; other site
430066007430	catalytic residues [active]
430066007431	active site lid [active]
430066007432	Protein of unknown function (DUF3478); Region: DUF3478; pfam11964
430066007433	ATP-dependent exoDNAse (exonuclease V), alpha subunit - helicase superfamily I member [DNA replication, recombination, and repair]; Region: RecD; COG0507
430066007434	AAA domain; Region: AAA_30; pfam13604
430066007435	Family description; Region: UvrD_C_2; pfam13538
430066007436	acetolactate synthase 3 regulatory subunit; Reviewed; Region: ilvH; PRK11895
430066007437	N-terminal ACT domain of the Escherichia coli IlvH-like regulatory subunit of acetohydroxyacid synthase (AHAS); Region: ACT_AHAS; cd04878
430066007438	putative valine binding site [chemical binding]; other site
430066007439	dimer interface [polypeptide binding]; other site
430066007440	Small subunit of acetolactate synthase; Region: ALS_ss_C; pfam10369
430066007441	acetolactate synthase 3 catalytic subunit; Validated; Region: PRK09107
430066007442	Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035
430066007443	PYR/PP interface [polypeptide binding]; other site
430066007444	dimer interface [polypeptide binding]; other site
430066007445	TPP binding site [chemical binding]; other site
430066007446	Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205
430066007447	Thiamine pyrophosphate (TPP) family, Acetohydroxyacid synthase (AHAS) subfamily, TPP-binding module; composed of proteins similar to the large catalytic subunit of AHAS. AHAS catalyzes the condensation of two molecules of pyruvate to give the...; Region: TPP_AHAS; cd02015
430066007448	TPP-binding site [chemical binding]; other site
430066007449	dimer interface [polypeptide binding]; other site
430066007450	tRNA delta(2)-isopentenylpyrophosphate transferase [Translation, ribosomal structure and biogenesis]; Region: MiaA; COG0324
430066007451	tRNA delta(2)-isopentenylpyrophosphate transferase; Reviewed; Region: miaA; PRK00091
430066007452	Phosphoserine phosphatase [Amino acid transport and metabolism]; Region: SerB; COG0560
430066007453	haloacid dehalogenase-like hydrolase; Region: HAD; cl17202
430066007454	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
430066007455	motif II; other site
430066007456	Predicted flavoproteins [General function prediction only]; Region: COG2081
430066007457	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
430066007458	periplasmic serine protease, Do/DeqQ family; Region: degP_htrA_DO; TIGR02037
430066007459	Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365
430066007460	PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987
430066007461	protein binding site [polypeptide binding]; other site
430066007462	PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987
430066007463	protein binding site [polypeptide binding]; other site
430066007464	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3242
430066007465	Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330
430066007466	Band_7_HflC: The band 7 domain of flotillin (reggie) like proteins. This group includes proteins similar to prokaryotic HlfC (High frequency of lysogenization C). Although many members of the band 7 family are lipid raft associated, prokaryote plasma...; Region: Band_7_HflC; cd03405
430066007467	Bacterial membrane protein N terminal; Region: HflK_N; pfam12221
430066007468	Band_7_HflK: The band 7 domain of flotillin (reggie) like proteins. This group includes proteins similar to prokaryotic HlfK (High frequency of lysogenization K). Although many members of the band 7 family are lipid raft associated, prokaryote plasma...; Region: Band_7_HflK; cd03404
430066007469	HflK protein; Region: hflK; TIGR01933
430066007470	Dihydrofolate reductase [Coenzyme metabolism]; Region: FolA; COG0262
430066007471	Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5; Region: DHFR; cd00209
430066007472	folate binding site [chemical binding]; other site
430066007473	NADP+ binding site [chemical binding]; other site
430066007474	thymidylate synthase; Reviewed; Region: thyA; PRK01827
430066007475	Thymidylate synthase and pyrimidine hydroxymethylase: Thymidylate synthase (TS) and deoxycytidylate hydroxymethylase (dCMP-HMase) are homologs that catalyze analogous alkylation of C5 of pyrimidine nucleotides. Both enzymes are involved in the...; Region: TS_Pyrimidine_HMase; cd00351
430066007476	dimerization interface [polypeptide binding]; other site
430066007477	active site
430066007478	Protein of unknown function (DUF2853); Region: DUF2853; pfam11015
430066007479	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
430066007480	putative substrate translocation pore; other site
430066007481	pyrimidine utilization regulatory protein R; Region: RutR; TIGR03613
430066007482	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
430066007483	AefR-like transcriptional repressor, C-terminal region; Region: TetR_C_7; pfam14246
430066007484	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3814
430066007485	Domain of unknown function (DUF4169); Region: DUF4169; pfam13770
430066007486	Uncharacterized protein related to arylsulfate sulfotransferase involved in siderophore biosynthesis [General function prediction only]; Region: COG4321
430066007487	Uncharacterized protein involved in outer membrane biogenesis [Cell envelope biogenesis, outer membrane]; Region: AsmA; COG2982
430066007488	AsmA-like C-terminal region; Region: AsmA_2; pfam13502
430066007489	FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277
430066007490	FAD binding domain; Region: FAD_binding_4; pfam01565
430066007491	Uncharacterized conserved protein [Function unknown]; Region: COG4702
430066007492	serine/threonine protein kinase; Provisional; Region: PRK09188
430066007493	serine/threonine protein kinase; Provisional; Region: PRK12274
430066007494	ATP-dependent DNA helicase PcrA; Region: pcrA; TIGR01073
430066007495	Part of AAA domain; Region: AAA_19; pfam13245
430066007496	Family description; Region: UvrD_C_2; pfam13538
430066007497	Uncharacterized protein conserved in bacteria [Function unknown]; Region: CreA; COG3045
430066007498	CreA protein; Region: CreA; pfam05981
430066007499	phosphonate metabolim protein, transferase hexapeptide repeat family; Region: phn_thr-fam; TIGR03308
430066007500	Xenobiotic acyltransferase (XAT): The XAT class of hexapeptide acyltransferases is composed of a large number of microbial enzymes that catalyze the CoA-dependent acetylation of a variety of hydroxyl-bearing acceptors such as chloramphenicol and...; Region: LbH_XAT; cd03349
430066007501	trimer interface [polypeptide binding]; other site
430066007502	active site
430066007503	substrate binding site [chemical binding]; other site
430066007504	CoA binding site [chemical binding]; other site
430066007505	Uncharacterized protein SCO1/SenC/PrrC, involved in biogenesis of respiratory and photosynthetic systems [General function prediction only]; Region: COG1999
430066007506	SCO (an acronym for Synthesis of Cytochrome c Oxidase) family; composed of proteins similar to Sco1, a membrane-anchored protein possessing a soluble domain with a TRX fold. Members of this family are required for the proper assembly of cytochrome c...; Region: SCO; cd02968
430066007507	Cu(I) binding site [ion binding]; other site
430066007508	Ribosomal protein L11 methylase [Translation, ribosomal structure and biogenesis]; Region: PrmA; COG2264
430066007509	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
430066007510	S-adenosylmethionine binding site [chemical binding]; other site
430066007511	Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321
430066007512	Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006
430066007513	X-Prolyl Aminopeptidase 2. E.C. 3.4.11.9. Also known as X-Pro aminopeptidase, proline aminopeptidase, aminopeptidase P, and aminoacylproline aminopeptidase. Catalyses release of any N-terminal amino acid, including proline, that is linked with proline; Region: APP; cd01085
430066007514	active site
430066007515	Uncharacterized conserved protein [Function unknown]; Region: COG5587
430066007516	NAD-dependent DNA ligase LigA; Validated; Region: ligA; PRK07956
430066007517	NAD+ dependent DNA ligase adenylation domain. DNA ligases catalyze the crucial step of joining the breaks in duplex DNA during DNA replication, repair and recombination, utilizing either ATP or NAD(+) as a cofactor, but using the same basic reaction...; Region: LIGANc; cd00114
430066007518	nucleotide binding pocket [chemical binding]; other site
430066007519	K-X-D-G motif; other site
430066007520	catalytic site [active]
430066007521	NAD-dependent DNA ligase OB-fold domain; Region: DNA_ligase_OB; pfam03120
430066007522	NAD-dependent DNA ligase C4 zinc finger domain; Region: DNA_ligase_ZBD; pfam03119
430066007523	Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo...; Region: BRCT; cd00027
430066007524	Dimer interface [polypeptide binding]; other site
430066007525	BRCT sequence motif; other site
430066007526	ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: RecN; COG0497
430066007527	ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241
430066007528	Walker A/P-loop; other site
430066007529	ATP binding site [chemical binding]; other site
430066007530	Q-loop/lid; other site
430066007531	ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241
430066007532	ABC transporter signature motif; other site
430066007533	Walker B; other site
430066007534	D-loop; other site
430066007535	H-loop/switch region; other site
430066007536	DNA uptake lipoprotein [General function prediction only]; Region: ComL; COG4105
430066007537	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429
430066007538	binding surface
430066007539	TPR motif; other site
430066007540	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase; Reviewed; Region: lpxC; PRK13186
430066007541	UDP-3-O-acyl N-acetylglycosamine deacetylase; Region: LpxC; pfam03331
430066007542	cell division protein FtsZ; Validated; Region: PRK09330
430066007543	FtsZ is a GTPase that is similar to the eukaryotic tubulins and is essential for cell division in prokaryotes.  FtsZ is capable of polymerizing in a GTP-driven process into structures similar to those formed by tubulin. FtsZ forms a ring-shaped septum at...; Region: FtsZ_type1; cd02201
430066007544	nucleotide binding site [chemical binding]; other site
430066007545	SulA interaction site; other site
430066007546	cell division protein FtsZ, alphaProteobacterial C-terminal extension; Region: FtsZ_alphas_C; TIGR03483
430066007547	Cell division ATPase FtsA [Cell division and chromosome partitioning]; Region: ftsA; COG0849
430066007548	Cell division protein FtsA; Region: FtsA; smart00842
430066007549	Cell division protein FtsA; Region: FtsA; pfam14450
430066007550	Cell division septal protein [Cell envelope biogenesis, outer membrane]; Region: FtsQ; COG1589
430066007551	POTRA domain, FtsQ-type; Region: POTRA_1; pfam08478
430066007552	Cell division protein FtsQ; Region: FtsQ; pfam03799
430066007553	D-alanine--D-alanine ligase; Reviewed; Region: ddl; PRK01372
430066007554	D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820
430066007555	ATP-grasp domain; Region: ATP-grasp_4; cl17255
430066007556	UDP-N-acetylenolpyruvoylglucosamine reductase; Provisional; Region: murB; PRK13905
430066007557	FAD binding domain; Region: FAD_binding_4; pfam01565
430066007558	UDP-N-acetylenolpyruvoylglucosamine reductase, C-terminal domain; Region: MurB_C; pfam02873
430066007559	UDP-N-acetylmuramate--L-alanine ligase; Provisional; Region: murC; PRK00421
430066007560	Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225
430066007561	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
430066007562	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
430066007563	MurG is an N-acetylglucosaminyltransferase, the last enzyme involved in the intracellular phase of peptidoglycan biosynthesis. It transfers N-acetyl-D-glucosamine (GlcNAc) from UDP-GlcNAc to the C4 hydroxyl of a lipid-linked N-acetylmuramoyl pentapeptide...; Region: GT1_MurG; cd03785
430066007564	undecaprenyldiphospho-muramoylpentapeptide beta-N- acetylglucosaminyltransferase; Provisional; Region: murG; PRK00726
430066007565	active site
430066007566	homodimer interface [polypeptide binding]; other site
430066007567	cell division protein FtsW; Region: ftsW; TIGR02614
430066007568	UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase; Provisional; Region: murD; PRK01390
430066007569	Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912
430066007570	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
430066007571	phospho-N-acetylmuramoyl-pentapeptide-transferase; Provisional; Region: mraY; PRK00108
430066007572	Phospho-N-acetylmuramoyl-pentapeptide-transferase (mraY) is an enzyme responsible for the formation of the first lipid intermediate in the synthesis of bacterial cell wall peptidoglycan. It catalyzes the formation of...; Region: GT_MraY; cd06852
430066007573	Mg++ binding site [ion binding]; other site
430066007574	putative catalytic motif [active]
430066007575	putative substrate binding site [chemical binding]; other site
430066007576	UDP-N-acetylmuramoylalanyl-D-glutamyl-2, 6-diaminopimelate--D-alanyl-D-alanine ligase; Provisional; Region: PRK14093
430066007577	Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225
430066007578	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
430066007579	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
430066007580	UDP-N-acetylmuramoylalanyl-D-glutamate--2, 6-diaminopimelate ligase; Provisional; Region: murE; PRK00139
430066007581	Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225
430066007582	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
430066007583	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
430066007584	Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768
430066007585	Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717
430066007586	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905
430066007587	Predicted secreted (periplasmic) protein [Function unknown]; Region: COG5462
430066007588	Predicted S-adenosylmethionine-dependent methyltransferase involved in cell envelope biogenesis [Cell envelope biogenesis, outer membrane]; Region: COG0275
430066007589	MraW methylase family; Region: Methyltransf_5; cl17771
430066007590	manganese transport protein MntH; Reviewed; Region: PRK00701
430066007591	Natural resistance-associated macrophage protein; Region: Nramp; pfam01566
430066007592	Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741
430066007593	Lytic Transglycosylase (LT)  and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL).  LTs...; Region: LT_GEWL; cd00254
430066007594	N-acetyl-D-glucosamine binding site [chemical binding]; other site
430066007595	catalytic residue [active]
430066007596	N-acetyl-anhydromuramyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: ampD; COG3023
430066007597	Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583
430066007598	amidase catalytic site [active]
430066007599	Zn binding residues [ion binding]; other site
430066007600	substrate binding site [chemical binding]; other site
430066007601	Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471
430066007602	N-terminal tellurium resistance protein terB-like domain of heat shock DnaJ-like proteins; Region: terB_like_DjlA; cd07316
430066007603	DnaJ-domain-containing proteins 1 [Posttranslational modification, protein turnover, chaperones]; Region: DjlA; COG1076
430066007604	putative metal binding site [ion binding]; other site
430066007605	DnaJ domain or J-domain.  DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257
430066007606	HSP70 interaction site [polypeptide binding]; other site
430066007607	Lyzozyme M1 (1,4-beta-N-acetylmuramidase) [Cell envelope biogenesis, outer membrane]; Region: Acm; COG3757
430066007608	Uncharacterized bacterial muramidase containing a glycosyl hydrolase family 25 (GH25) catalytic domain. Endo-N-acetylmuramidases are lysozymes (also referred to as peptidoglycan hydrolases) that degrade bacterial cell walls by catalyzing the hydrolysis...; Region: GH25_muramidase_1; cd06413
430066007609	active site
430066007610	Membrane-bound lytic murein transglycosylase B [Cell envelope biogenesis, outer membrane]; Region: MltB; COG2951
430066007611	murein hydrolase B; Provisional; Region: PRK10760; cl17906
430066007612	Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471
430066007613	Predicted permeases [General function prediction only]; Region: COG0679
430066007614	Methylenetetrahydrofolate reductase (MTHFR). 5,10-Methylenetetrahydrofolate is reduced to 5-methyltetrahydrofolate by methylenetetrahydrofolate reductase, a cytoplasmic, NAD(P)-dependent enzyme. 5-methyltetrahydrofolate is utilized by methionine synthase...; Region: MTHFR; cd00537
430066007615	FAD binding site [chemical binding]; other site
430066007616	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
430066007617	dimerization interface [polypeptide binding]; other site
430066007618	putative DNA binding site [nucleotide binding]; other site
430066007619	putative Zn2+ binding site [ion binding]; other site
430066007620	Methyltransferase domain; Region: Methyltransf_23; pfam13489
430066007621	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
430066007622	S-adenosylmethionine binding site [chemical binding]; other site
430066007623	Uncharacterized conserved protein [Function unknown]; Region: COG5586
430066007624	alpha-ketoglutarate transporter; Provisional; Region: PRK10406
430066007625	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
430066007626	putative substrate translocation pore; other site
430066007627	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173
430066007628	putative ABC transporter ATP-binding protein; Reviewed; Region: PRK11819
430066007629	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
430066007630	Walker A/P-loop; other site
430066007631	ATP binding site [chemical binding]; other site
430066007632	Q-loop/lid; other site
430066007633	ABC transporter signature motif; other site
430066007634	Walker B; other site
430066007635	D-loop; other site
430066007636	H-loop/switch region; other site
430066007637	ABC transporter; Region: ABC_tran_2; pfam12848
430066007638	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
430066007639	Lysophospholipase [Lipid metabolism]; Region: PldB; COG2267
430066007640	Putative lysophospholipase; Region: Hydrolase_4; pfam12146
430066007641	PGAP1-like protein; Region: PGAP1; pfam07819
430066007642	Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638
430066007643	Rieske non-heme iron oxygenase (RO) family, N-terminal Rieske domain of the oxygenase alpha subunit; The RO family comprise a large class of aromatic ring-hydroxylating dioxygenases found predominantly in microorganisms. These enzymes enable...; Region: Rieske_RO_Alpha_N; cd03469
430066007644	[2Fe-2S] cluster binding site [ion binding]; other site
430066007645	C-terminal catalytic domain of GbcA (glycine betaine catabolism A) from Pseudomonas aeruginosa PAO1 and related aromatic ring hydroxylating dioxygenases; Region: RHO_alpha_C_GbcA-like; cd08884
430066007646	putative alpha subunit interface [polypeptide binding]; other site
430066007647	putative active site [active]
430066007648	putative substrate binding site [chemical binding]; other site
430066007649	Fe binding site [ion binding]; other site
430066007650	Flavodoxin reductases (ferredoxin-NADPH reductases) family 1 [Energy production and conversion]; Region: Hmp; COG1018
430066007651	Iron-sulfur binding ferredoxin reductase (FNR) proteins combine the FAD and NAD(P) binding regions of FNR with an iron-sulfur binding cluster domain. Ferredoxin-NADP+ (oxido)reductase is an FAD-containing enzyme that catalyzes the reversible electron...; Region: FNR_iron_sulfur_binding_1; cd06215
430066007652	FAD binding pocket [chemical binding]; other site
430066007653	FAD binding motif [chemical binding]; other site
430066007654	phosphate binding motif [ion binding]; other site
430066007655	beta-alpha-beta structure motif; other site
430066007656	NAD binding pocket [chemical binding]; other site
430066007657	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
430066007658	catalytic loop [active]
430066007659	iron binding site [ion binding]; other site
430066007660	Uncharacterized Zn-ribbon-containing protein involved in phosphonate metabolism [Inorganic ion transport and metabolism]; Region: PhnA; COG2824
430066007661	PhnA protein; Region: PhnA; pfam03831
430066007662	Isochorismatase family; Region: Isochorismatase; pfam00857
430066007663	Nicotinamidase/pyrazinamidase (PZase). Nicotinamidase, a ubiquitous enzyme in prokaryotes, converts nicotinamide to nicotinic acid (niacin) and ammonia, which in turn can be recycled to make nicotinamide adenine dinucleotide (NAD). The same enzyme is...; Region: nicotinamidase; cd01011
430066007664	catalytic triad [active]
430066007665	metal binding site [ion binding]; metal-binding site
430066007666	conserved cis-peptide bond; other site
430066007667	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2899
430066007668	Penicillin V acylase (PVA), also known as conjugated bile salt acid hydrolase (CBAH), catalyzes the hydrolysis of penicillin V to yield 6-amino penicillanic acid (6-APA), an important key intermediate of semisynthetic penicillins.  PVA has an N-terminal...; Region: Ntn_PVA; cd00542
430066007669	Linear amide C-N hydrolases, choloylglycine hydrolase family; Region: CBAH; pfam02275
430066007670	active site
430066007671	outer membrane protein; Region: OMP_w_GlyGly; TIGR04219
430066007672	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
430066007673	DNA binding site [nucleotide binding]
430066007674	active site
430066007675	Int/Topo IB signature motif; other site
430066007676	Uncharacterized conserved protein [Function unknown]; Region: COG2968
430066007677	Protein of unknown function (DUF541); Region: SIMPL; pfam04402
430066007678	hypothetical protein; Provisional; Region: PRK05170
430066007679	Uncharacterized conserved protein [Function unknown]; Region: COG5453
430066007680	RNA polymerase sigma factor RpoD; Validated; Region: PRK05658
430066007681	Sigma-70 factor, region 1.1; Region: Sigma70_r1_1; pfam03979
430066007682	Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140
430066007683	Sigma-70, non-essential region; Region: Sigma70_ner; pfam04546
430066007684	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
430066007685	Sigma-70 region 3; Region: Sigma70_r3; pfam04539
430066007686	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
430066007687	DNA binding residues [nucleotide binding]
430066007688	DNA primase; Validated; Region: dnaG; PRK05667
430066007689	CHC2 zinc finger; Region: zf-CHC2; pfam01807
430066007690	DNA primase catalytic core, N-terminal domain; Region: Toprim_N; pfam08275
430066007691	TOPRIM_DnaG_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of proteins similar to Escherichia coli DnaG. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_DnaG_primases; cd03364
430066007692	active site
430066007693	metal binding site [ion binding]; metal-binding site
430066007694	interdomain interaction site; other site
430066007695	Na+/phosphate symporter [Inorganic ion transport and metabolism]; Region: NptA; COG1283
430066007696	Na+/Pi-cotransporter; Region: Na_Pi_cotrans; pfam02690
430066007697	Na+/Pi-cotransporter; Region: Na_Pi_cotrans; pfam02690
430066007698	PhoU domain; Region: PhoU; pfam01895
430066007699	PhoU domain; Region: PhoU; pfam01895
430066007700	Uncharacterized conserved protein [Function unknown]; Region: COG1610
430066007701	carbamoyl phosphate synthase small subunit; Reviewed; Region: PRK12564
430066007702	Carbamoyl-phosphate synthase small chain, CPSase domain; Region: CPSase_sm_chain; smart01097
430066007703	Small chain of the glutamine-dependent form of carbamoyl phosphate synthase, CPSase II; Region: GATase1_CPSase; cd01744
430066007704	catalytic site [active]
430066007705	subunit interface [polypeptide binding]; other site
430066007706	Predicted metalloprotease [General function prediction only]; Region: COG2321
430066007707	Putative neutral zinc metallopeptidase; Region: Zn_peptidase; pfam04228
430066007708	Predicted membrane protein [Function unknown]; Region: COG5395
430066007709	Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms]; Region: LytT; COG3279
430066007710	LytTr DNA-binding domain; Region: LytTR; cl04498
430066007711	carbamoyl phosphate synthase large subunit; Reviewed; Region: carB; PRK05294
430066007712	Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289
430066007713	ATP-grasp domain; Region: ATP-grasp_4; cl17255
430066007714	Carbamoyl-phosphate synthetase large chain, oligomerisation domain; Region: CPSase_L_D3; pfam02787
430066007715	Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289
430066007716	ATP-grasp domain; Region: ATP-grasp_4; cl17255
430066007717	Methylglyoxal synthase-like domain from type II glutamine-dependent carbamoyl phosphate synthetase (CSP). CSP, a CarA and CarB heterodimer, catalyzes the production of carbamoyl phosphate which is subsequently employed in the metabolic pathways...; Region: MGS_CPS_II; cd01424
430066007718	IMP binding site; other site
430066007719	dimer interface [polypeptide binding]; other site
430066007720	partial ornithine binding site; other site
430066007721	ABC-type uncharacterized transport system, permease and ATPase components [General function prediction only]; Region: COG4178
430066007722	ABC transporter transmembrane region 2; Region: ABC_membrane_2; cl00549
430066007723	ATP-binding cassette domain of peroxisomal transporter, subfamily D; Region: ABCD_peroxisomal_ALDP; cd03223
430066007724	NUDIX domain; Region: NUDIX; pfam00293
430066007725	nudix motif; other site
430066007726	Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea.  CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458
430066007727	DNA-binding site [nucleotide binding]; DNA binding site
430066007728	RNA-binding motif; other site
430066007729	Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625
430066007730	GST_N family, unknown subfamily 4; composed of uncharacterized bacterial proteins with similarity to GSTs. GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of...; Region: GST_N_4; cd03056
430066007731	putative C-terminal domain interface [polypeptide binding]; other site
430066007732	putative GSH binding site (G-site) [chemical binding]; other site
430066007733	putative dimer interface [polypeptide binding]; other site
430066007734	C-terminal, alpha helical domain of the Glutathione S-transferase family; Region: GST_C_family; cl02776
430066007735	N-terminal domain interface [polypeptide binding]; other site
430066007736	dimer interface [polypeptide binding]; other site
430066007737	substrate binding pocket (H-site) [chemical binding]; other site
430066007738	aspartate aminotransferase; Provisional; Region: PRK05764
430066007739	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
430066007740	pyridoxal 5'-phosphate binding site [chemical binding]; other site
430066007741	homodimer interface [polypeptide binding]; other site
430066007742	catalytic residue [active]
430066007743	Transcriptional regulator [Transcription]; Region: LysR; COG0583
430066007744	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
430066007745	The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422
430066007746	putative effector binding pocket; other site
430066007747	dimerization interface [polypeptide binding]; other site
430066007748	thioredoxin-disulfide reductase; Region: TRX_reduct; TIGR01292
430066007749	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
430066007750	Trk-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: TrkG; COG0168
430066007751	potassium uptake protein, TrkH family; Region: 2a38; TIGR00933
430066007752	Transcriptional regulators [Transcription]; Region: Lrp; COG1522
430066007753	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
430066007754	putative DNA binding site [nucleotide binding]; other site
430066007755	putative Zn2+ binding site [ion binding]; other site
430066007756	AsnC family; Region: AsnC_trans_reg; pfam01037
430066007757	This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801
430066007758	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
430066007759	transcription elongation factor GreA; Reviewed; Region: greA; PRK00226
430066007760	Transcription elongation factor, N-terminal; Region: GreA_GreB_N; pfam03449
430066007761	Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272
430066007762	Protein of unknown function (DUF1176); Region: DUF1176; pfam06674
430066007763	Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697
430066007764	EamA-like transporter family; Region: EamA; pfam00892
430066007765	EamA-like transporter family; Region: EamA; pfam00892
430066007766	Protein of unknown function, DUF486; Region: DUF486; cl01236
430066007767	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3921
430066007768	Extensin-like protein C-terminus; Region: Extensin-like_C; pfam06904
430066007769	Brown fat-inducible thioesterase (BFIT).  Brain acyl-CoA hydrolase (BACH).  These enzymes deacylate long-chain fatty acids by hydrolyzing acyl-CoA thioesters to free fatty acids and CoA-SH. Eukaryotic members of this family are expressed in brain, testis; Region: BFIT_BACH; cd03442
430066007770	Uncharacterized protein with a bacterial SH3 domain homologue [Function unknown]; Region: COG4991
430066007771	Bacterial SH3 domain; Region: SH3_3; pfam08239
430066007772	excinuclease ABC subunit B; Provisional; Region: PRK05298
430066007773	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
430066007774	ATP binding site [chemical binding]; other site
430066007775	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
430066007776	nucleotide binding region [chemical binding]; other site
430066007777	ATP-binding site [chemical binding]; other site
430066007778	Ultra-violet resistance protein B; Region: UvrB; pfam12344
430066007779	UvrB/uvrC motif; Region: UVR; pfam02151
430066007780	Lytic Transglycosylase (LT)  and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL).  LTs...; Region: LT_GEWL; cd00254
430066007781	N-acetyl-D-glucosamine binding site [chemical binding]; other site
430066007782	catalytic residue [active]
430066007783	Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea.  CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458
430066007784	DNA-binding site [nucleotide binding]; DNA binding site
430066007785	RNA-binding motif; other site
430066007786	BA14K-like protein; Region: BA14K; pfam07886
430066007787	Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491
430066007788	helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347
430066007789	MarR family; Region: MarR_2; pfam12802
430066007790	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
430066007791	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
430066007792	active site
430066007793	phosphorylation site [posttranslational modification]
430066007794	intermolecular recognition site; other site
430066007795	dimerization interface [polypeptide binding]; other site
430066007796	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
430066007797	DNA binding site [nucleotide binding]
430066007798	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cl00080
430066007799	dimer interface [polypeptide binding]; other site
430066007800	phosphorylation site [posttranslational modification]
430066007801	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
430066007802	ATP binding site [chemical binding]; other site
430066007803	Mg2+ binding site [ion binding]; other site
430066007804	G-X-G motif; other site
430066007805	tRNA-binding-domain-containing CsaA-like proteins. CsaA is a molecular chaperone with export related activities. CsaA has a putative tRNA binding activity. The functional unit of CsaA is a homodimer and this domain acts as a dimerization domain; Region: tRNA_bind_CsaA; cd02798
430066007806	dimer interface [polypeptide binding]; other site
430066007807	putative tRNA-binding site [nucleotide binding]; other site
430066007808	Uncharacterized conserved protein [Function unknown]; Region: COG5465
430066007809	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2960
430066007810	prolipoprotein diacylglyceryl transferase; Reviewed; Region: PRK00052
430066007811	Putative S-adenosyl-L-methionine-dependent methyltransferase; Region: Methyltransf_28; pfam02636
430066007812	Multicopper polyphenol oxidase (laccase) [Secondary metabolites biosynthesis, transport and catabolism]; Region: yfiH; COG1496
430066007813	Multi-copper polyphenol oxidoreductase laccase; Region: Cu-oxidase_4; pfam02578
430066007814	Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006
430066007815	Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321
430066007816	A family including aminopeptidase P, aminopeptidase M, and prolidase. Also known as metallopeptidase family M24. This family of enzymes is able to cleave amido-, imido- and amidino-containing bonds. Members exibit relatively narrow substrate specificity...; Region: APP_MetAP; cd01066
430066007817	active site
430066007818	ribose-phosphate pyrophosphokinase; Provisional; Region: PRK01259
430066007819	N-terminal domain of ribose phosphate pyrophosphokinase; Region: Pribosyltran_N; pfam13793
430066007820	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
430066007821	active site
430066007822	HerA helicase [Replication, recombination, and repair]; Region: COG0433
430066007823	50S ribosomal protein L25/general stress protein Ctc; Reviewed; Region: PRK05618
430066007824	Ribosomal L25/TL5/CTC N-terminal 5S rRNA binding domain; Region: Ribosomal_L25_TL5_CTC; cd00495
430066007825	5S rRNA interface [nucleotide binding]; other site
430066007826	CTC domain interface [polypeptide binding]; other site
430066007827	L16 interface [polypeptide binding]; other site
430066007828	Peptidyl-tRNA hydrolase (PTH) is a monomeric protein that cleaves the ester bond linking the nascent peptide and tRNA when peptidyl-tRNA is released prematurely from the ribosome. This ensures the recycling of peptidyl-tRNAs into tRNAs produced through...; Region: PTH; cd00462
430066007829	putative active site [active]
430066007830	GTP-binding protein YchF; Reviewed; Region: PRK09601
430066007831	YchF GTPase; Region: YchF; cd01900
430066007832	G1 box; other site
430066007833	GTP/Mg2+ binding site [chemical binding]; other site
430066007834	Switch I region; other site
430066007835	G2 box; other site
430066007836	Switch II region; other site
430066007837	G3 box; other site
430066007838	G4 box; other site
430066007839	G5 box; other site
430066007840	TGS_YchF_C: This subfamily represents TGS domain-containing YchF GTP-binding protein, a universally conserved GTPase whose function is unknown. The N-terminal domain of the YchF protein belongs to the Obg-like family of GTPases, and some members of the...; Region: TGS_YchF_C; cd04867
430066007841	The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509
430066007842	active site 1 [active]
430066007843	active site 2 [active]
430066007844	YdeM is a Bacillus subtilis protein that belongs to a family of prokaryotic proteins of unkown function.  YdeM has sequence similarity to the hot-dog fold of (R)-specific enoyl-CoA hydratase.   Other enzymes with this fold include the peroxisomal...; Region: YdeM; cd03454
430066007845	putative active site [active]
430066007846	putative catalytic site [active]
430066007847	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
430066007848	active site
430066007849	Cytochrome C1 family; Region: Cytochrom_C1; pfam02167
430066007850	cytochrome b; Provisional; Region: CYTB; MTH00191
430066007851	Cytochrome b (N-terminus)/b6/petB:  Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria; Region: Cytochrome_b_N; cd00284
430066007852	Qi binding site; other site
430066007853	intrachain domain interface; other site
430066007854	interchain domain interface [polypeptide binding]; other site
430066007855	heme bH binding site [chemical binding]; other site
430066007856	heme bL binding site [chemical binding]; other site
430066007857	Qo binding site; other site
430066007858	Cytochrome b(C-terminus)/b6/petD:  Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria; Region: cytochrome_b_C; cd00290
430066007859	interchain domain interface [polypeptide binding]; other site
430066007860	intrachain domain interface; other site
430066007861	Qi binding site; other site
430066007862	Qo binding site; other site
430066007863	Ubiquitinol-cytochrome C reductase Fe-S subunit TAT signal; Region: UCR_Fe-S_N; pfam10399
430066007864	ubiquinol-cytochrome c reductase, iron-sulfur subunit; Region: Rieske_proteo; TIGR01416
430066007865	Iron-sulfur protein (ISP) component of the bc(1) complex family, Rieske domain; The Rieske domain is a [2Fe-2S] cluster binding domain involved in electron transfer. The bc(1) complex is a multisubunit enzyme found in many different organisms including...; Region: Rieske_cytochrome_bc1; cd03470
430066007866	[2Fe-2S] cluster binding site [ion binding]; other site
430066007867	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
430066007868	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
430066007869	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
430066007870	Walker A/P-loop; other site
430066007871	ATP binding site [chemical binding]; other site
430066007872	Q-loop/lid; other site
430066007873	ABC transporter signature motif; other site
430066007874	Walker B; other site
430066007875	D-loop; other site
430066007876	H-loop/switch region; other site
430066007877	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
430066007878	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
430066007879	ATP-binding cassette domain of the bacterial lipid flippase and related proteins, subfamily C; Region: ABCC_MsbA; cd03251
430066007880	Walker A/P-loop; other site
430066007881	ATP binding site [chemical binding]; other site
430066007882	Q-loop/lid; other site
430066007883	ABC transporter signature motif; other site
430066007884	Walker B; other site
430066007885	D-loop; other site
430066007886	H-loop/switch region; other site
430066007887	Predicted rRNA methylase (SpoU class) [Translation, ribosomal structure and biogenesis]; Region: CspR; COG0219
430066007888	Purine nucleoside permease [Nucleotide transport and metabolism]; Region: NUP; COG5042
430066007889	coproporphyrinogen III oxidase; Provisional; Region: PRK05330
430066007890	Coproporphyrinogen III oxidase; Region: Coprogen_oxidas; cl17752
430066007891	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
430066007892	Coenzyme A binding pocket [chemical binding]; other site
430066007893	Aspartyl/Asparaginyl beta-hydroxylase; Region: Asp_Arg_Hydrox; cl17820
430066007894	Aspartyl/asparaginyl beta-hydroxylase and related dioxygenases [Posttranslational modification, protein turnover, chaperones]; Region: COG3555
430066007895	tRNA nucleotidyltransferase/poly(A) polymerase [Translation, ribosomal structure and biogenesis]; Region: PcnB; COG0617
430066007896	Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398
430066007897	active site
430066007898	NTP binding site [chemical binding]; other site
430066007899	metal binding triad [ion binding]; metal-binding site
430066007900	Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627
430066007901	Coenzyme A pyrophosphatase (CoAse), a member of the Nudix hydrolase superfamily, functions to catalyze the elimination of oxidized inactive CoA, which can inhibit CoA-utilizing enzymes. The need of CoAses mainly arises under conditions of oxidative...; Region: CoAse; cd03426
430066007902	putative active site [active]
430066007903	putative CoA binding site [chemical binding]; other site
430066007904	nudix motif; other site
430066007905	metal binding site [ion binding]; metal-binding site
430066007906	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3816
430066007907	Protein of unknown function (DUF1285); Region: DUF1285; pfam06938
430066007908	MoxR-like ATPases [General function prediction only]; Region: COG0714
430066007909	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189
430066007910	ATP binding site [chemical binding]; other site
430066007911	Walker B motif; other site
430066007912	arginine finger; other site
430066007913	Uncharacterized conserved protein (some members contain a von Willebrand factor type A (vWA) domain) [General function prediction only]; Region: COG1721
430066007914	Protein of unknown function DUF58; Region: DUF58; pfam01882
430066007915	N-terminal double-transmembrane domain; Region: two_anch; TIGR02226
430066007916	A4 beta-galactosidase middle domain: a type 1 glutamine amidotransferase (GATase1)-like domain; Region: A4_beta-galactosidase_middle_domain; cd03143
430066007917	Domain of unknown function (DUF4159); Region: DUF4159; pfam13709
430066007918	Protein of unknown function (DUF1355); Region: DUF1355; cl17712
430066007919	Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673
430066007920	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
430066007921	Coenzyme A binding pocket [chemical binding]; other site
430066007922	Predicted glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: ECM4; COG0435
430066007923	Glutathione S-transferase, N-terminal domain; Region: GST_N_2; pfam13409
430066007924	C-terminal, alpha helical domain of Class Omega-like Glutathione S-transferases; Region: GST_C_Omega_like; cd03190
430066007925	putative dimer interface [polypeptide binding]; other site
430066007926	N-terminal domain interface [polypeptide binding]; other site
430066007927	putative substrate binding pocket (H-site) [chemical binding]; other site
430066007928	Outer membrane protein W [Cell envelope biogenesis, outer membrane]; Region: OmpW; COG3047
430066007929	Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_21; cd04680
430066007930	nudix motif; other site
430066007931	metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995
430066007932	Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149
430066007933	active site
430066007934	metal binding site [ion binding]; metal-binding site
430066007935	2-isopropylmalate synthase; Validated; Region: PRK03739
430066007936	Mycobacterium tuberculosis LeuA3 and related proteins, N-terminal catalytic TIM barrel domain; Region: DRE_TIM_LeuA; cd07942
430066007937	active site
430066007938	catalytic residues [active]
430066007939	metal binding site [ion binding]; metal-binding site
430066007940	LeuA allosteric (dimerisation) domain; Region: LeuA_dimer; smart00917
430066007941	Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053
430066007942	Cation efflux family; Region: Cation_efflux; pfam01545
430066007943	anthranilate synthase; Provisional; Region: PRK13566
430066007944	Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715
430066007945	chorismate binding enzyme; Region: Chorismate_bind; pfam00425
430066007946	Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743
430066007947	glutamine binding [chemical binding]; other site
430066007948	catalytic triad [active]
430066007949	leucine-responsive transcriptional regulator; Provisional; Region: PRK11169
430066007950	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
430066007951	putative DNA binding site [nucleotide binding]; other site
430066007952	putative Zn2+ binding site [ion binding]; other site
430066007953	AsnC family; Region: AsnC_trans_reg; pfam01037
430066007954	Transcriptional regulators [Transcription]; Region: MarR; COG1846
430066007955	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
430066007956	putative substrate translocation pore; other site
430066007957	oxalate/formate antiporter family transporter; Region: 2A0111; TIGR00890
430066007958	Predicted rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: COG5459
430066007959	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5345
430066007960	ABC-type proline/glycine betaine transport systems, periplasmic components [Amino acid transport and metabolism]; Region: ProX; COG2113
430066007961	choline ABC transporter, periplasmic binding protein; Region: ABC_choline_bnd; TIGR03414
430066007962	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
430066007963	dimer interface [polypeptide binding]; other site
430066007964	conserved gate region; other site
430066007965	putative PBP binding loops; other site
430066007966	ABC-ATPase subunit interface; other site
430066007967	choline ABC transporter, ATP-binding protein; Region: ABC_choXWV_ATP; TIGR03415
430066007968	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
430066007969	Walker A/P-loop; other site
430066007970	ATP binding site [chemical binding]; other site
430066007971	Q-loop/lid; other site
430066007972	ABC transporter signature motif; other site
430066007973	Walker B; other site
430066007974	D-loop; other site
430066007975	H-loop/switch region; other site
430066007976	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
430066007977	ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124
430066007978	Walker A/P-loop; other site
430066007979	ATP binding site [chemical binding]; other site
430066007980	Q-loop/lid; other site
430066007981	ABC transporter signature motif; other site
430066007982	Walker B; other site
430066007983	D-loop; other site
430066007984	H-loop/switch region; other site
430066007985	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; pfam08352
430066007986	ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124
430066007987	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
430066007988	Walker A/P-loop; other site
430066007989	ATP binding site [chemical binding]; other site
430066007990	Q-loop/lid; other site
430066007991	ABC transporter signature motif; other site
430066007992	Walker B; other site
430066007993	D-loop; other site
430066007994	H-loop/switch region; other site
430066007995	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; pfam08352
430066007996	dipeptide transporter; Provisional; Region: PRK10913
430066007997	N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911
430066007998	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
430066007999	dimer interface [polypeptide binding]; other site
430066008000	conserved gate region; other site
430066008001	putative PBP binding loops; other site
430066008002	ABC-ATPase subunit interface; other site
430066008003	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601
430066008004	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
430066008005	dimer interface [polypeptide binding]; other site
430066008006	conserved gate region; other site
430066008007	putative PBP binding loops; other site
430066008008	ABC-ATPase subunit interface; other site
430066008009	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
430066008010	dimerization interface [polypeptide binding]; other site
430066008011	putative DNA binding site [nucleotide binding]; other site
430066008012	putative Zn2+ binding site [ion binding]; other site
430066008013	rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566
430066008014	RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; smart00967
430066008015	SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588
430066008016	Predicted tRNA(5-methylaminomethyl-2-thiouridylate) methyltransferase, contains the PP-loop ATPase domain [Translation, ribosomal structure and biogenesis]; Region: TrmU; COG0482
430066008017	tRNA methyl transferase. This family represents tRNA(5-methylaminomethyl-2-thiouridine)-methyltransferase which is involved in the biosynthesis of the modified nucleoside 5-methylaminomethyl-2-thiouridine present in the wobble position of some tRNAs; Region: tRNA_Me_trans; cd01998
430066008018	Ligand Binding Site [chemical binding]; other site
430066008019	Protein of unknown function (DUF1153); Region: DUF1153; pfam06627
430066008020	Predicted acetyltransferase [General function prediction only]; Region: COG2388
430066008021	chromosome segregation protein SMC, primarily archaeal type; Region: SMC_prok_A; TIGR02169
430066008022	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5400
430066008023	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5385
430066008024	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
430066008025	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
430066008026	active site
430066008027	phosphorylation site [posttranslational modification]
430066008028	intermolecular recognition site; other site
430066008029	dimerization interface [polypeptide binding]; other site
430066008030	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
430066008031	DNA binding site [nucleotide binding]
430066008032	Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WecE; COG0399
430066008033	3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616
430066008034	inhibitor-cofactor binding pocket; inhibition site
430066008035	pyridoxal 5'-phosphate binding site [chemical binding]; other site
430066008036	catalytic residue [active]
430066008037	Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673
430066008038	Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408
430066008039	Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894
430066008040	Glycosyltransferase family 25 [lipooligosaccharide (LOS) biosynthesis protein] is a family of glycosyltransferases involved in LOS biosynthesis. The members include the beta(1,4) galactosyltransferases: Lgt2 of Moraxella catarrhalis, LgtB and LgtE of...; Region: Glyco_transf_25; cd06532
430066008041	PAS domain; Region: PAS_8; pfam13188
430066008042	phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966
430066008043	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
430066008044	putative active site [active]
430066008045	heme pocket [chemical binding]; other site
430066008046	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
430066008047	dimer interface [polypeptide binding]; other site
430066008048	phosphorylation site [posttranslational modification]
430066008049	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
430066008050	ATP binding site [chemical binding]; other site
430066008051	Mg2+ binding site [ion binding]; other site
430066008052	G-X-G motif; other site
430066008053	Uncharacterized protein involved in outer membrane biogenesis [Cell envelope biogenesis, outer membrane]; Region: AsmA; COG2982
430066008054	AsmA-like C-terminal region; Region: AsmA_2; pfam13502
430066008055	ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177
430066008056	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
430066008057	dimer interface [polypeptide binding]; other site
430066008058	conserved gate region; other site
430066008059	putative PBP binding loops; other site
430066008060	ABC-ATPase subunit interface; other site
430066008061	ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842
430066008062	ATP-binding cassette domain of the polyamine transporter; Region: ABC_PotA_N; cd03300
430066008063	Walker A/P-loop; other site
430066008064	ATP binding site [chemical binding]; other site
430066008065	Q-loop/lid; other site
430066008066	ABC transporter signature motif; other site
430066008067	Walker B; other site
430066008068	D-loop; other site
430066008069	H-loop/switch region; other site
430066008070	TOBE domain; Region: TOBE_2; pfam08402
430066008071	putrescine transporter subunit: periplasmic-binding component of ABC superfamily; Provisional; Region: PRK10682
430066008072	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199
430066008073	Predicted transcriptional regulator [General function prediction only]; Region: COG3800
430066008074	Domain of unknown function (DUF955); Region: DUF955; pfam06114
430066008075	Predicted transcriptional regulator (DUF2083); Region: DUF2083; pfam09856
430066008076	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
430066008077	non-specific DNA binding site [nucleotide binding]; other site
430066008078	salt bridge; other site
430066008079	sequence-specific DNA binding site [nucleotide binding]; other site
430066008080	isocitrate lyase; Provisional; Region: PRK15063
430066008081	Members of the ICL/PEPM enzyme family catalyze either P-C or C-C bond formation/cleavage. Known members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate hydrolase (OAH), isocitrate...; Region: ICL_PEPM; cd00377
430066008082	tetramer interface [polypeptide binding]; other site
430066008083	active site
430066008084	Mg2+/Mn2+ binding site [ion binding]; other site
430066008085	7-alpha-hydroxysteroid dehydrogenase; Validated; Region: PRK06113
430066008086	7 alpha-hydroxysteroid dehydrogenase (7 alpha-HSDH), classical (c) SDRs; Region: 7_alpha_HSDH_SDR_c; cd05365
430066008087	NAD binding site [chemical binding]; other site
430066008088	substrate binding site [chemical binding]; other site
430066008089	homotetramer interface [polypeptide binding]; other site
430066008090	homodimer interface [polypeptide binding]; other site
430066008091	active site
430066008092	7-alpha-hydroxysteroid dehydrogenase; Validated; Region: PRK06113
430066008093	7 alpha-hydroxysteroid dehydrogenase (7 alpha-HSDH), classical (c) SDRs; Region: 7_alpha_HSDH_SDR_c; cd05365
430066008094	NAD binding site [chemical binding]; other site
430066008095	substrate binding site [chemical binding]; other site
430066008096	homotetramer interface [polypeptide binding]; other site
430066008097	homodimer interface [polypeptide binding]; other site
430066008098	active site
430066008099	Multiple antibiotic transporter [Intracellular trafficking and secretion]; Region: MarC; COG2095
430066008100	Opacity protein and related surface antigens [Cell envelope biogenesis, outer membrane]; Region: COG3637
430066008101	Patatins and Phospholipases; Region: Patatin_and_cPLA2; cl11396
430066008102	active site
430066008103	nucleophile elbow; other site
430066008104	Peptidase propeptide and YPEB domain; Region: PepSY_2; pfam13670
430066008105	Dihydroxyacetone kinase [Carbohydrate transport and metabolism]; Region: DAK1; COG2376
430066008106	DAK2 domain; Region: Dak2; cl03685
430066008107	DAK2 domain; Region: Dak2; pfam02734
430066008108	Dihydroxyacetone kinase [Carbohydrate transport and metabolism]; Region: DAK1; COG2376
430066008109	dihydroxyacetone kinase subunit DhaK; Provisional; Region: PRK14481; cl10557
430066008110	short chain dehydrogenase; Provisional; Region: PRK06841
430066008111	classical (c) SDRs; Region: SDR_c; cd05233
430066008112	NAD(P) binding site [chemical binding]; other site
430066008113	active site
430066008114	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: RbsB; COG1879
430066008115	Periplasmic binding proteins specific to rhizopines; Region: PBP1_rhizopine_binding_like; cd06301
430066008116	putative ligand binding site [chemical binding]; other site
430066008117	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
430066008118	Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579
430066008119	TM-ABC transporter signature motif; other site
430066008120	ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129
430066008121	First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216
430066008122	Walker A/P-loop; other site
430066008123	ATP binding site [chemical binding]; other site
430066008124	Q-loop/lid; other site
430066008125	ABC transporter signature motif; other site
430066008126	Walker B; other site
430066008127	D-loop; other site
430066008128	H-loop/switch region; other site
430066008129	Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215
430066008130	Uncharacterized conserved protein [Function unknown]; Region: COG5591
430066008131	choline dehydrogenase; Validated; Region: PRK02106
430066008132	GMC oxidoreductase; Region: GMC_oxred_C; pfam05199
430066008133	Transcriptional regulator [Transcription]; Region: IclR; COG1414
430066008134	IclR helix-turn-helix domain; Region: HTH_IclR; pfam09339
430066008135	Bacterial transcriptional regulator; Region: IclR; pfam01614
430066008136	succinic semialdehyde dehydrogenase; Region: PLN02278
430066008137	Mitochondrial succinate-semialdehyde dehydrogenase and ALDH family members 5A1 and 5F1-like; Region: ALDH_F5_SSADH_GabD; cd07103
430066008138	tetramerization interface [polypeptide binding]; other site
430066008139	NAD(P) binding site [chemical binding]; other site
430066008140	catalytic residues [active]
430066008141	Predicted membrane protein [Function unknown]; Region: COG1238
430066008142	Disulfide bond formation protein DsbB [Posttranslational modification, protein turnover, chaperones]; Region: DsbB; COG1495
430066008143	Restriction endonuclease [Defense mechanisms]; Region: McrA; COG1403
430066008144	HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085
430066008145	active site
430066008146	3-methyladenine DNA glycosylase/8-oxoguanine DNA glycosylase [DNA replication, recombination, and repair]; Region: AlkA; COG0122
430066008147	endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056
430066008148	helix-hairpin-helix signature motif; other site
430066008149	substrate binding pocket [chemical binding]; other site
430066008150	active site
430066008151	glutamyl-Q tRNA(Asp) synthetase; Reviewed; Region: PRK05710
430066008152	Glutamyl- and glutaminyl-tRNA synthetases [Translation, ribosomal structure and biogenesis]; Region: GlnS; COG0008
430066008153	active site
430066008154	HIGH motif; other site
430066008155	nucleotide binding site [chemical binding]; other site
430066008156	active site
430066008157	KMSKS motif; other site
430066008158	Malate synthase G (MSG), monomeric enzyme present in some bacteria. In general, malate synthase catalyzes the Claisen condensation of glyoxylate and acetyl-CoA to malyl-CoA , which hydrolyzes to malate and CoA. This reaction is part of the glyoxylate...; Region: malate_synt_G; cd00728
430066008159	active site
430066008160	Sortase and related acyltransferases [Cell envelope biogenesis, outer membrane]; Region: COG1247
430066008161	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
430066008162	Coenzyme A binding pocket [chemical binding]; other site
430066008163	RNA polymerase factor sigma-32; Reviewed; Region: PRK06596
430066008164	Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140
430066008165	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
430066008166	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
430066008167	DNA binding residues [nucleotide binding]
430066008168	Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564
430066008169	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
430066008170	RNA binding surface [nucleotide binding]; other site
430066008171	Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869
430066008172	active site
430066008173	Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153
430066008174	metal binding site 2 [ion binding]; metal-binding site
430066008175	putative DNA binding helix; other site
430066008176	metal binding site 1 [ion binding]; metal-binding site
430066008177	dimer interface [polypeptide binding]; other site
430066008178	structural Zn2+ binding site [ion binding]; other site
430066008179	PAS fold; Region: PAS_4; pfam08448
430066008180	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920
430066008181	HWE histidine kinase; Region: HWE_HK; pfam07536
430066008182	two-component response regulator; Provisional; Region: PRK09191
430066008183	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
430066008184	active site
430066008185	phosphorylation site [posttranslational modification]
430066008186	intermolecular recognition site; other site
430066008187	dimerization interface [polypeptide binding]; other site
430066008188	RNA polymerase sigma factor; Provisional; Region: PRK12516
430066008189	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
430066008190	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
430066008191	DNA binding residues [nucleotide binding]
430066008192	CHASE3 domain; Region: CHASE3; pfam05227
430066008193	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920
430066008194	Histidine kinase; Region: HisKA_2; pfam07568
430066008195	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
430066008196	ATP binding site [chemical binding]; other site
430066008197	Mg2+ binding site [ion binding]; other site
430066008198	G-X-G motif; other site
430066008199	Bacterial protein of unknown function (DUF883); Region: DUF883; pfam05957
430066008200	PRC-barrel domain; Region: PRC; pfam05239
430066008201	PRC-barrel domain; Region: PRC; pfam05239
430066008202	tonB-system energizer ExbB; Region: exbB; TIGR02797
430066008203	Biopolymer transport protein [Intracellular trafficking and secretion]; Region: ExbD; COG0848
430066008204	TonB system transport protein ExbD, group 1; Region: ExbD_1; TIGR02803
430066008205	Periplasmic protein TonB, links inner and outer membranes [Cell envelope biogenesis, outer membrane]; Region: TonB; COG0810
430066008206	TonB family C-terminal domain; Region: tonB_Cterm; TIGR01352
430066008207	Predicted periplasmic protein [Function unknown]; Region: COG3698
430066008208	Predicted periplasmic protein (DUF2233); Region: DUF2233; pfam09992
430066008209	MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
430066008210	FtsX-like permease family; Region: FtsX; pfam02687
430066008211	ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255
430066008212	ABC transporter; Region: ABC_tran; pfam00005
430066008213	Q-loop/lid; other site
430066008214	ABC transporter signature motif; other site
430066008215	Walker B; other site
430066008216	D-loop; other site
430066008217	H-loop/switch region; other site
430066008218	MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
430066008219	ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577
430066008220	macrolide transporter subunit MacA; Provisional; Region: PRK11578
430066008221	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
430066008222	HlyD family secretion protein; Region: HlyD_3; pfam13437
430066008223	Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557
430066008224	trimer interface [polypeptide binding]; other site
430066008225	active site
430066008226	Transcriptional regulators [Transcription]; Region: Lrp; COG1522
430066008227	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
430066008228	dimerization interface [polypeptide binding]; other site
430066008229	putative DNA binding site [nucleotide binding]; other site
430066008230	putative Zn2+ binding site [ion binding]; other site
430066008231	AsnC family; Region: AsnC_trans_reg; pfam01037
430066008232	Predicted glutamine amidotransferase [General function prediction only]; Region: COG0121
430066008233	Glutamine amidotransferases class-II (Gn-AT)_YafJ-type.  YafJ is a glutamine amidotransferase-like protein of unknown function found in prokaryotes, eukaryotes and archaea.  YafJ has a conserved structural fold similar to those of other class II...; Region: YafJ; cd01908
430066008234	putative active site [active]
430066008235	putative dimer interface [polypeptide binding]; other site
430066008236	Uncharacterized family of ferritin-like proteins found in archaea and bacteria; Region: Ferritin_like_AB; cd01045
430066008237	diiron binding motif [ion binding]; other site
430066008238	Uncharacterized conserved protein [Function unknown]; Region: COG1633
430066008239	CCC1-related protein family; Region: CCC1_like_1; cd02437
430066008240	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
430066008241	metabolite-proton symporter; Region: 2A0106; TIGR00883
430066008242	putative substrate translocation pore; other site
430066008243	Adenylosuccinate synthetase; Region: Adenylsucc_synt; smart00788
430066008244	Adenylosuccinate synthetase (AdSS) catalyzes the first step in the de novo biosynthesis of AMP. IMP and L-aspartate are conjugated in a two-step reaction accompanied by the hydrolysis of GTP to GDP in the presence of Mg2+. In the first step, the...; Region: AdSS; cd03108
430066008245	GDP-binding site [chemical binding]; other site
430066008246	ACT binding site; other site
430066008247	IMP binding site; other site
430066008248	Acetyltransferases [General function prediction only]; Region: RimI; COG0456
430066008249	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
430066008250	Coenzyme A binding pocket [chemical binding]; other site
430066008251	D-3-phosphoglycerate dehydrogenase; Provisional; Region: PRK13581
430066008252	Phosphoglycerate dehydrogenases, NAD-binding and catalytic domains; Region: PGDH_4; cd12173
430066008253	ligand binding site [chemical binding]; other site
430066008254	NAD binding site [chemical binding]; other site
430066008255	dimerization interface [polypeptide binding]; other site
430066008256	catalytic site [active]
430066008257	C-terminal ACT (regulatory) domain of D-3-phosphoglycerate dehydrogenase (3PGDH); Region: ACT_3PGDH-xct; cd04902
430066008258	putative L-serine binding site [chemical binding]; other site
430066008259	Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cd01494
430066008260	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
430066008261	Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321
430066008262	catalytic residue [active]
430066008263	regulatory RNA structure; BAbS19_Ir0009
430066008264	Predicted Na+-dependent transporter [General function prediction only]; Region: COG0385
430066008265	Sodium Bile acid symporter family; Region: SBF; pfam01758
430066008266	Opacity protein and related surface antigens [Cell envelope biogenesis, outer membrane]; Region: COG3637
430066008267	phosphoglucosamine mutase; Provisional; Region: glmM; PRK14315
430066008268	GlmM is a bacterial phosphoglucosamine mutase (PNGM) that belongs to the alpha-D-phosphohexomutase superfamily. It is required for the interconversion of glucosamine-6-phosphate and glucosamine-1-phosphate in the biosynthetic pathway of...; Region: GlmM; cd05802
430066008269	active site
430066008270	substrate binding site [chemical binding]; other site
430066008271	metal binding site [ion binding]; metal-binding site
430066008272	FtsH Extracellular; Region: FtsH_ext; pfam06480
430066008273	ATP-dependent metalloprotease FtsH; Region: FtsH_fam; TIGR01241
430066008274	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
430066008275	Walker A motif; other site
430066008276	ATP binding site [chemical binding]; other site
430066008277	Walker B motif; other site
430066008278	arginine finger; other site
430066008279	Peptidase family M41; Region: Peptidase_M41; pfam01434
430066008280	tRNA(Ile)-lysidine synthase MesJ [Cell cycle control, cell division, chromosome partitioning]; Region: MesJ; COG0037
430066008281	N-terminal domain of predicted ATPase of the PP-loop faimly implicated in cell cycle control [Cell division and chromosome partitioning]. This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases...; Region: PP-ATPase; cd01992
430066008282	tol-pal system protein YbgF; Region: tol_pal_ybgF; TIGR02795
430066008283	Tetratricopeptide repeat; Region: TPR_6; pfam13174
430066008284	Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885
430066008285	Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185
430066008286	ligand binding site [chemical binding]; other site
430066008287	translocation protein TolB; Provisional; Region: tolB; PRK05137
430066008288	TolB amino-terminal domain; Region: TolB_N; pfam04052
430066008289	WD40-like Beta Propeller Repeat; Region: PD40; pfam07676
430066008290	WD40-like Beta Propeller Repeat; Region: PD40; pfam07676
430066008291	Biopolymer transport protein [Intracellular trafficking and secretion]; Region: ExbD; COG0848
430066008292	TolR protein; Region: tolR; TIGR02801
430066008293	TolQ protein; Region: tolQ; TIGR02796
430066008294	4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586
430066008295	active site
430066008296	Holliday junction DNA helicase RuvB; Reviewed; Region: ruvB; PRK00080
430066008297	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
430066008298	Walker A motif; other site
430066008299	ATP binding site [chemical binding]; other site
430066008300	Walker B motif; other site
430066008301	Holliday junction DNA helicase ruvB C-terminus; Region: RuvB_C; pfam05491
430066008302	Holliday junction DNA helicase RuvA; Reviewed; Region: ruvA; PRK00116
430066008303	RuvA N terminal domain; Region: RuvA_N; pfam01330
430066008304	RuvA, C-terminal domain; Region: RuvA_C; pfam07499
430066008305	Holliday junction resolvases (HJRs) are endonucleases that specifically resolve Holliday junction DNA intermediates during homologous recombination. HJR's occur in archaea, bacteria, and in the mitochondria of certain fungi, however this CD...; Region: RuvC_resolvase; cd00529
430066008306	active site
430066008307	putative DNA-binding cleft [nucleotide binding]; other site
430066008308	dimer interface [polypeptide binding]; other site
430066008309	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5317
430066008310	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4645
430066008311	Acyltransferase family; Region: Acyl_transf_3; pfam01757
430066008312	Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5-; Region: TMP_TenI; cd00564
430066008313	active site
430066008314	thiamine phosphate binding site [chemical binding]; other site
430066008315	pyrophosphate binding site [ion binding]; other site
430066008316	FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790
430066008317	Sel1-like repeats; Region: SEL1; smart00671
430066008318	Sel1-like repeats; Region: SEL1; smart00671
430066008319	elongation factor P; Validated; Region: PRK00529
430066008320	Elongation factor P (EF-P) KOW-like domain; Region: EFP_N; pfam08207
430066008321	S1_EF-P_repeat_1: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_1; cd04470
430066008322	RNA binding site [nucleotide binding]; other site
430066008323	S1_EF-P_repeat_2: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_2; cd05794
430066008324	RNA binding site [nucleotide binding]; other site
430066008325	Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483
430066008326	IMPase, inositol monophosphatase and related domains. A family of Mg++ dependent phosphatases, inhibited by lithium, many of which may act on inositol monophosphate substrate. They dephosphorylate inositol phosphate to generate inositol, which may be...; Region: IMPase; cd01639
430066008327	active site
430066008328	dimerization interface [polypeptide binding]; other site
430066008329	hypothetical protein; Validated; Region: PRK09039
430066008330	Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185
430066008331	ligand binding site [chemical binding]; other site
430066008332	ABC transporter, permease/ATP-binding protein; Region: MsbA_rel; TIGR02204
430066008333	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
430066008334	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
430066008335	Walker A/P-loop; other site
430066008336	ATP binding site [chemical binding]; other site
430066008337	Q-loop/lid; other site
430066008338	ABC transporter signature motif; other site
430066008339	Walker B; other site
430066008340	D-loop; other site
430066008341	H-loop/switch region; other site
430066008342	50S ribosomal protein L31; Reviewed; Region: rpmE; PRK00528
430066008343	hypothetical protein; Validated; Region: PRK00110
430066008344	Transcriptional regulators [Transcription]; Region: GntR; COG1802
430066008345	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
430066008346	DNA-binding site [nucleotide binding]; DNA binding site
430066008347	FCD domain; Region: FCD; pfam07729
430066008348	Uncharacterized conserved protein [General function prediction only]; Region: BioY; COG1268
430066008349	Uncharacterized conserved protein [Function unknown]; Region: COG3543
430066008350	Membrane protein TerC, possibly involved in tellurium resistance [Inorganic ion transport and metabolism]; Region: TerC; COG0861
430066008351	Deinococcus radiodurans DR1281 and related proteins, metallophosphatase domain; Region: MPP_DR1281; cd07382
430066008352	Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149
430066008353	putative active site [active]
430066008354	metal binding site [ion binding]; metal-binding site
430066008355	homodimer binding site [polypeptide binding]; other site
430066008356	5-formyltetrahydrofolate cyclo-ligase [Coenzyme metabolism]; Region: COG0212
430066008357	Cell division protein ZapA (stimulator of FtsZ polymerization and Z-ring component) [Cell cycle control, cell division,    chromosome partitioning]; Region: zapA; COG3027
430066008358	Domain of unknown function (DUF4164); Region: DUF4164; pfam13747
430066008359	Transketolase [Carbohydrate transport and metabolism]; Region: TktA; COG0021
430066008360	Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012
430066008361	TPP-binding site [chemical binding]; other site
430066008362	dimer interface [polypeptide binding]; other site
430066008363	Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033
430066008364	PYR/PP interface [polypeptide binding]; other site
430066008365	dimer interface [polypeptide binding]; other site
430066008366	TPP binding site [chemical binding]; other site
430066008367	Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780
430066008368	Glyceraldehyde-3-phosphate dehydrogenase/erythrose-4-phosphate dehydrogenase [Carbohydrate transport and metabolism]; Region: GapA; COG0057
430066008369	Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; smart00846
430066008370	Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800
430066008371	Phosphoglycerate kinase; Region: PGK; pfam00162
430066008372	Phosphoglycerate kinase (PGK) is a monomeric enzyme which catalyzes the transfer of the high-energy phosphate group of 1,3-bisphosphoglycerate to ADP, forming ATP and 3-phosphoglycerate. This reaction represents the first of the two substrate-level...; Region: Phosphoglycerate_kinase; cd00318
430066008373	substrate binding site [chemical binding]; other site
430066008374	hinge regions; other site
430066008375	ADP binding site [chemical binding]; other site
430066008376	catalytic site [active]
430066008377	propionyl-CoA synthetase; Provisional; Region: prpE; PRK10524
430066008378	Propionyl-CoA synthetase (PrpE); Region: PrpE; cd05967
430066008379	acyl-activating enzyme (AAE) consensus motif; other site
430066008380	putative AMP binding site [chemical binding]; other site
430066008381	putative active site [active]
430066008382	putative CoA binding site [chemical binding]; other site
430066008383	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
430066008384	Predicted transcriptional regulator [Transcription]; Region: COG2378
430066008385	HTH domain; Region: HTH_11; pfam08279
430066008386	WYL domain; Region: WYL; pfam13280
430066008387	PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria.  Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443
430066008388	CoenzymeA binding site [chemical binding]; other site
430066008389	subunit interaction site [polypeptide binding]; other site
430066008390	PHB binding site; other site
430066008391	Thioesterase-like superfamily; Region: 4HBT_3; pfam13622
430066008392	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3820
430066008393	putative NAD(P)H quinone oxidoreductase, PIG3 family; Region: quinone_pig3; TIGR02824
430066008394	PIG3 p53-inducible quinone oxidoreductase; Region: p53_inducible_oxidoreductase; cd05276
430066008395	NAD(P) binding site [chemical binding]; other site
430066008396	Uncharacterized small protein containing a coiled-coil domain [Function unknown]; Region: COG5509
430066008397	Uncharacterized small protein [Function unknown]; Region: COG5570
430066008398	Uncharacterized conserved small protein containing a coiled-coil domain [Function unknown]; Region: COG5481
430066008399	Phosphoribosylcarboxyaminoimidazole (NCAIR) mutase [Nucleotide transport and metabolism]; Region: PurE; COG0041
430066008400	phosphoribosylaminoimidazole carboxylase ATPase subunit; Reviewed; Region: PRK06019
430066008401	Formate/glycerate dehydrogenases, D-specific 2-hydroxy acid dehydrogenases and related dehydrogenases; Region: FDH_GDH_like; cl17240
430066008402	NAD binding site [chemical binding]; other site
430066008403	ATP-grasp domain; Region: ATP-grasp; pfam02222
430066008404	50S ribosomal protein L36; Validated; Region: rpmJ; PRK00831
430066008405	TPR repeat; Region: TPR_11; pfam13414
430066008406	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
430066008407	TPR motif; other site
430066008408	binding surface
430066008409	pyruvate kinase; Provisional; Region: PRK06247
430066008410	Pyruvate kinase (PK):  Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl17342
430066008411	domain interfaces; other site
430066008412	active site
430066008413	Predicted integral membrane protein [Function unknown]; Region: COG5480
430066008414	Predicted N-formylglutamate amidohydrolase [Amino acid transport and metabolism]; Region: COG3931
430066008415	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3750
430066008416	ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488
430066008417	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
430066008418	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
430066008419	Thiamine pyrophosphokinase [Coenzyme metabolism]; Region: THI80; COG1564
430066008420	Thiamine pyrophosphokinase; Region: TPK; cd07995
430066008421	active site
430066008422	dimerization interface [polypeptide binding]; other site
430066008423	thiamine binding site [chemical binding]; other site
430066008424	ABC-type thiamine transport system, periplasmic component [Coenzyme metabolism]; Region: TbpA; COG4143
430066008425	thiamine transporter substrate binding subunit; Provisional; Region: tbpA; PRK11205
430066008426	thiamine transporter membrane protein; Reviewed; Region: thiP; PRK09433
430066008427	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
430066008428	dimer interface [polypeptide binding]; other site
430066008429	conserved gate region; other site
430066008430	putative PBP binding loops; other site
430066008431	ABC-ATPase subunit interface; other site
430066008432	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
430066008433	dimer interface [polypeptide binding]; other site
430066008434	conserved gate region; other site
430066008435	putative PBP binding loops; other site
430066008436	ABC-ATPase subunit interface; other site
430066008437	ABC-type thiamine transport system, ATPase component [Coenzyme metabolism]; Region: ThiQ; COG3840
430066008438	ATP-binding cassette domain of the thiamine transport system; Region: ABC_ThiQ_thiamine_transporter; cd03298
430066008439	Walker A/P-loop; other site
430066008440	ATP binding site [chemical binding]; other site
430066008441	Q-loop/lid; other site
430066008442	ABC transporter signature motif; other site
430066008443	Walker B; other site
430066008444	D-loop; other site
430066008445	H-loop/switch region; other site
430066008446	Putative Zn-dependent protease [General function prediction only]; Region: COG4784
430066008447	Peptidase family M48; Region: Peptidase_M48; pfam01435
430066008448	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2258
430066008449	MOSC domain; Region: MOSC; pfam03473
430066008450	3-alpha domain; Region: 3-alpha; pfam03475
430066008451	RNA polymerase factor sigma-32; Reviewed; Region: rpoH2; PRK07500
430066008452	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
430066008453	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
430066008454	DNA binding residues [nucleotide binding]
430066008455	Transcriptional regulators, similar to M. xanthus CarD [Transcription]; Region: COG1329
430066008456	Ferredoxin [Energy production and conversion]; Region: COG1146
430066008457	4Fe-4S binding domain; Region: Fer4; pfam00037
430066008458	Domain of unknown function (DUF3470); Region: DUF3470; pfam11953
430066008459	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
430066008460	RNA binding surface [nucleotide binding]; other site
430066008461	DEAD/DEAH box helicase; Region: DEAD; pfam00270
430066008462	ATP binding site [chemical binding]; other site
430066008463	Superfamily II DNA and RNA helicases [DNA replication, recombination, and repair / Transcription / Translation, ribosomal structure and biogenesis]; Region: SrmB; COG0513
430066008464	putative Mg++ binding site [ion binding]; other site
430066008465	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
430066008466	nucleotide binding region [chemical binding]; other site
430066008467	ATP-binding site [chemical binding]; other site
430066008468	putative acyltransferase; Provisional; Region: PRK05790
430066008469	Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751
430066008470	dimer interface [polypeptide binding]; other site
430066008471	active site
430066008472	Uncharacterized protein, possibly involved in utilization of glycolate and propanediol [General function prediction only]; Region: GlcG; COG3193
430066008473	Ribosomal protein L32 [Translation, ribosomal structure and biogenesis]; Region: RpmF; COG0333
430066008474	monofunctional biosynthetic peptidoglycan transglycosylase; Provisional; Region: mtgA; PRK00056
430066008475	Transglycosylase; Region: Transgly; pfam00912
430066008476	Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142
430066008477	Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685
430066008478	substrate binding pocket [chemical binding]; other site
430066008479	chain length determination region; other site
430066008480	substrate-Mg2+ binding site; other site
430066008481	catalytic residues [active]
430066008482	aspartate-rich region 1; other site
430066008483	active site lid residues [active]
430066008484	aspartate-rich region 2; other site
430066008485	4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Reviewed; Region: ispG; PRK00366
430066008486	4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694
430066008487	4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694
430066008488	3-hydroxybutyrate dehydrogenase; Region: PHB_DH; TIGR01963
430066008489	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
430066008490	NAD(P) binding site [chemical binding]; other site
430066008491	active site
430066008492	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
430066008493	Major Facilitator Superfamily; Region: MFS_1; pfam07690
430066008494	putative substrate translocation pore; other site
430066008495	pyruvate carboxylase; Reviewed; Region: PRK12999
430066008496	Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289
430066008497	ATP-grasp domain; Region: ATP-grasp_4; cl17255
430066008498	Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878
430066008499	Pyruvate carboxylase and Transcarboxylase 5S, carboxyltransferase domain; Region: DRE_TIM_PC_TC_5S; cd07937
430066008500	active site
430066008501	catalytic residues [active]
430066008502	metal binding site [ion binding]; metal-binding site
430066008503	homodimer binding site [polypeptide binding]; other site
430066008504	The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850
430066008505	carboxyltransferase (CT) interaction site; other site
430066008506	biotinylation site [posttranslational modification]; other site
430066008507	ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683
430066008508	Type I periplasmic ligand-binding domain of ABC (Atpase Binding Cassette)-type active transport systems that are involved in the transport of all three branched chain aliphatic amino acids (leucine, isoleucine and valine); Region: PBP1_ABC_LIVBP_like; cd06342
430066008509	dimerization interface [polypeptide binding]; other site
430066008510	ligand binding site [chemical binding]; other site
430066008511	ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683
430066008512	Type I periplasmic ligand-binding domain of ABC (Atpase Binding Cassette)-type active transport systems that are involved in the transport of all three branched chain aliphatic amino acids (leucine, isoleucine and valine); Region: PBP1_ABC_LIVBP_like; cd06342
430066008513	dimerization interface [polypeptide binding]; other site
430066008514	ligand binding site [chemical binding]; other site
430066008515	ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410
430066008516	ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224
430066008517	Walker A/P-loop; other site
430066008518	ATP binding site [chemical binding]; other site
430066008519	Q-loop/lid; other site
430066008520	ABC transporter signature motif; other site
430066008521	Walker B; other site
430066008522	D-loop; other site
430066008523	H-loop/switch region; other site
430066008524	ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411
430066008525	ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219
430066008526	Walker A/P-loop; other site
430066008527	ATP binding site [chemical binding]; other site
430066008528	Q-loop/lid; other site
430066008529	ABC transporter signature motif; other site
430066008530	Walker B; other site
430066008531	D-loop; other site
430066008532	H-loop/switch region; other site
430066008533	Uncharacterized conserved protein [Function unknown]; Region: COG3743
430066008534	leucine/isoleucine/valine transporter permease subunit; Provisional; Region: livM; PRK11301
430066008535	Domain of unknown function (DUF3382); Region: DUF3382; pfam11862
430066008536	Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581
430066008537	TM-ABC transporter signature motif; other site
430066008538	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
430066008539	Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582
430066008540	TM-ABC transporter signature motif; other site
430066008541	Proline racemase [Amino acid transport and metabolism]; Region: COG3938
430066008542	hydroxyproline-2-epimerase; Provisional; Region: PRK13971
430066008543	Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665
430066008544	Transcriptional regulators [Transcription]; Region: FadR; COG2186
430066008545	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
430066008546	DNA-binding site [nucleotide binding]; DNA binding site
430066008547	FCD domain; Region: FCD; pfam07729
430066008548	MarR family; Region: MarR; pfam01047
430066008549	transcriptional regulator SlyA; Provisional; Region: PRK03573
430066008550	F0F1-type ATP synthase, epsilon subunit (mitochondrial delta subunit) [Energy production and conversion]; Region: AtpC; COG0355
430066008551	mitochondrial ATP synthase delta subunit; Region: F1-ATPase_delta; cd12152
430066008552	gamma subunit interface [polypeptide binding]; other site
430066008553	epsilon subunit interface [polypeptide binding]; other site
430066008554	LBP interface [polypeptide binding]; other site
430066008555	F0F1 ATP synthase subunit beta; Validated; Region: PRK09280
430066008556	ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874
430066008557	F1 ATP synthase beta subunit, nucleotide-binding domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a...; Region: F1-ATPase_beta; cd01133
430066008558	alpha subunit interaction interface [polypeptide binding]; other site
430066008559	Walker A motif; other site
430066008560	ATP binding site [chemical binding]; other site
430066008561	Walker B motif; other site
430066008562	inhibitor binding site; inhibition site
430066008563	ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306
430066008564	mitochondrial ATP synthase gamma subunit; Region: F1-ATPase_gamma; cd12151
430066008565	core domain interface [polypeptide binding]; other site
430066008566	delta subunit interface [polypeptide binding]; other site
430066008567	epsilon subunit interface [polypeptide binding]; other site
430066008568	F0F1 ATP synthase subunit alpha; Validated; Region: PRK09281
430066008569	ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874
430066008570	F1 ATP synthase alpha, central domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a proton gradient to...; Region: F1_ATPase_alpha; cd01132
430066008571	beta subunit interaction interface [polypeptide binding]; other site
430066008572	Walker A motif; other site
430066008573	ATP binding site [chemical binding]; other site
430066008574	Walker B motif; other site
430066008575	ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306
430066008576	F0F1 ATP synthase subunit delta; Validated; Region: PRK05758
430066008577	ATP synthase delta (OSCP) subunit; Region: OSCP; pfam00213
430066008578	primosome assembly protein PriA; Validated; Region: PRK05580
430066008579	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
430066008580	ATP binding site [chemical binding]; other site
430066008581	putative Mg++ binding site [ion binding]; other site
430066008582	helicase superfamily c-terminal domain; Region: HELICc; smart00490
430066008583	nucleotide binding region [chemical binding]; other site
430066008584	ATP-binding site [chemical binding]; other site
430066008585	Transaldolase-like fructose-6-phosphate aldolases (FSA) found in bacteria and archaea; Region: Transaldolase_FSA; cd00956
430066008586	active site
430066008587	intersubunit interactions; other site
430066008588	catalytic residue [active]
430066008589	Predicted secreted (periplasmic) protein [Function unknown]; Region: COG5468
430066008590	leucyl-tRNA synthetase; Validated; Region: leuS; PRK00390
430066008591	catalytic core domain of leucyl-tRNA synthetases; Region: LeuRS_core; cd00812
430066008592	HIGH motif; other site
430066008593	Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603
430066008594	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
430066008595	active site
430066008596	KMSKS motif; other site
430066008597	Anticodon-binding domain of bacterial and eukaryotic mitochondrial leucyl tRNA synthetases; Region: Anticodon_Ia_Leu_BEm; cd07958
430066008598	tRNA binding surface [nucleotide binding]; other site
430066008599	Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes, YBL036c-like proteins; Region: PLPDE_III_YBL036c_like; cd00635
430066008600	pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site
430066008601	catalytic residue [active]
430066008602	Predicted membrane protein [Function unknown]; Region: COG1289
430066008603	Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515
430066008604	Usg protein, probable subunit of phosphoribosylanthranilate isomerase [Amino acid transport and metabolism]; Region: COG5425
430066008605	acetyl-CoA synthetase; Provisional; Region: PRK00174
430066008606	Acetyl-CoA synthetase (also known as acetate-CoA ligase and acetyl-activating enzyme); Region: ACS; cd05966
430066008607	active site
430066008608	CoA binding site [chemical binding]; other site
430066008609	acyl-activating enzyme (AAE) consensus motif; other site
430066008610	AMP binding site [chemical binding]; other site
430066008611	acetate binding site [chemical binding]; other site
430066008612	Uncharacterized conserved small protein [Function unknown]; Region: COG5508
430066008613	Protein of unknown function (DUF1674); Region: DUF1674; pfam07896
430066008614	heat shock protein HtpX; Provisional; Region: PRK01345
430066008615	NusB family; Region: NusB; pfam01029
430066008616	tRNA and rRNA cytosine-C5-methylases [Translation, ribosomal structure and biogenesis]; Region: Sun; COG0144
430066008617	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
430066008618	S-adenosylmethionine binding site [chemical binding]; other site
430066008619	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5360
430066008620	bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; Provisional; Region: purH; PRK00881
430066008621	Inosine monophosphate cyclohydrolase domain. This is the N-terminal domain in the purine biosynthesis pathway protein ATIC (purH). The bifunctional ATIC protein contains a C-terminal  ATIC formylase domain that formylates...; Region: IMPCH; cd01421
430066008622	purine monophosphate binding site [chemical binding]; other site
430066008623	dimer interface [polypeptide binding]; other site
430066008624	putative catalytic residues [active]
430066008625	AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; smart00798
430066008626	AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; cl03362
430066008627	Permeases of the major facilitator superfamily [General function prediction only]; Region: COG2270
430066008628	Bacterial NAD-glutamate dehydrogenase; Region: Bac_GDH; pfam05088
430066008629	Predicted membrane protein [Function unknown]; Region: COG3762
430066008630	Beta-propeller domains of methanol dehydrogenase type [General function prediction only]; Region: COG1512
430066008631	Repair protein; Region: Repair_PSII; pfam04536
430066008632	Uncharacterized conserved protein [Function unknown]; Region: LemA; COG1704
430066008633	30S ribosomal protein S16; Reviewed; Region: rpsP; PRK00040
430066008634	chorismate mutase; Provisional; Region: PRK09239
430066008635	signal recognition particle protein; Provisional; Region: PRK10867
430066008636	SRP54-type protein, helical bundle domain; Region: SRP54_N; smart00963
430066008637	The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115
430066008638	P loop; other site
430066008639	GTP binding site [chemical binding]; other site
430066008640	Signal peptide binding domain; Region: SRP_SPB; pfam02978
430066008641	lytic murein transglycosylase; Region: MltB_2; TIGR02283
430066008642	murein hydrolase B; Provisional; Region: PRK10760; cl17906
430066008643	Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA_cladeB; cd00884
430066008644	active site clefts [active]
430066008645	zinc binding site [ion binding]; other site
430066008646	dimer interface [polypeptide binding]; other site
430066008647	pyridoxamine kinase; Validated; Region: PRK05756
430066008648	Pyridoxal kinase plays a key role in the synthesis of the active coenzyme pyridoxal-5'-phosphate  (PLP), by catalyzing the phosphorylation of the precursor vitamin B6  in the presence of Zn2+ and ATP. Mammals are unable to synthesize PLP de novo and...; Region: pyridoxal_pyridoxamine_kinase; cd01173
430066008649	dimer interface [polypeptide binding]; other site
430066008650	pyridoxal binding site [chemical binding]; other site
430066008651	ATP binding site [chemical binding]; other site
430066008652	Methylmalonate semialdehyde dehydrogenase and ALDH family members 6A1 and 6B2; Region: ALDH_F6_MMSDH; cd07085
430066008653	methylmalonic acid semialdehyde dehydrogenase; Region: MMSDH; TIGR01722
430066008654	tetrameric interface [polypeptide binding]; other site
430066008655	NAD binding site [chemical binding]; other site
430066008656	catalytic residues [active]
430066008657	Transcriptional regulator [Transcription]; Region: LysR; COG0583
430066008658	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
430066008659	The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422
430066008660	putative effector binding pocket; other site
430066008661	dimerization interface [polypeptide binding]; other site
430066008662	Predicted membrane protein [Function unknown]; Region: COG3619
430066008663	Diadenosine tetraphosphate (Ap4A) hydrolase is a member of the Nudix hydrolase superfamily. Members of this family are well represented in a variety of prokaryotic and eukaryotic organisms. Phylogenetic analysis reveals two distinct subgroups where plant...; Region: Ap4A_hydrolase_plant_like; cd03671
430066008664	putative active site [active]
430066008665	Ap4A binding site [chemical binding]; other site
430066008666	nudix motif; other site
430066008667	putative metal binding site [ion binding]; other site
430066008668	Periplasmic protease [Cell envelope biogenesis, outer membrane]; Region: Prc; COG0793
430066008669	C-terminal processing peptidase family S41; Region: Peptidase_S41; cl02526
430066008670	PDZ domain of C-terminal processing-, tail-specific-, and tricorn proteases, which function in posttranslational protein processing, maturation, and disassembly or degradation, in Bacteria, Archaea, and plant chloroplasts. May be responsible for...; Region: PDZ_CTP_protease; cd00988
430066008671	protein binding site [polypeptide binding]; other site
430066008672	C-terminal processing peptidase; serine protease family S41; Region: Peptidase_S41_CPP; cd07560
430066008673	Catalytic dyad [active]
430066008674	Membrane-bound metallopeptidase [Cell division and chromosome partitioning]; Region: COG4942
430066008675	Peptidase family M23; Region: Peptidase_M23; pfam01551
430066008676	rRNA large subunit methyltransferase; Provisional; Region: PRK00103
430066008677	Uncharacterized homolog of plant Iojap protein [Function unknown]; Region: COG0799
430066008678	Nicotinamide/nicotinate mononucleotide adenylyltransferase; Region: NMNAT; cd02165
430066008679	Cytidylyltransferase; Region: CTP_transf_2; pfam01467
430066008680	active site
430066008681	(T/H)XGH motif; other site
430066008682	Gamma-glutamyl phosphate reductase (GPR), aldehyde dehydrogenase families 18 and 19; Region: ALDH_F18-19_ProA-GPR; cd07079
430066008683	gamma-glutamyl phosphate reductase; Region: proA; TIGR00407
430066008684	putative catalytic cysteine [active]
430066008685	gamma-glutamyl kinase; Provisional; Region: PRK05429
430066008686	AAK_G5K_ProB: Glutamate-5-kinase (G5K) catalyzes glutamate-dependent ATP cleavage; G5K transfers the terminal phosphoryl group of ATP to the gamma-carboxyl group of glutamate, in the first and controlling step of proline (and, in mammals, ornithine)...; Region: AAK_G5K_ProB; cd04242
430066008687	nucleotide binding site [chemical binding]; other site
430066008688	homotetrameric interface [polypeptide binding]; other site
430066008689	putative phosphate binding site [ion binding]; other site
430066008690	putative allosteric binding site; other site
430066008691	PUA domain; Region: PUA; pfam01472
430066008692	GTPase CgtA; Reviewed; Region: obgE; PRK12299
430066008693	GTP1/OBG; Region: GTP1_OBG; pfam01018
430066008694	Obg GTPase; Region: Obg; cd01898
430066008695	G1 box; other site
430066008696	GTP/Mg2+ binding site [chemical binding]; other site
430066008697	Switch I region; other site
430066008698	G2 box; other site
430066008699	G3 box; other site
430066008700	Switch II region; other site
430066008701	G4 box; other site
430066008702	G5 box; other site
430066008703	YadA-like C-terminal region; Region: YadA; pfam03895
430066008704	Sortase and related acyltransferases [Cell envelope biogenesis, outer membrane]; Region: COG1247
430066008705	Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583
430066008706	Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302
430066008707	Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583
430066008708	50S ribosomal protein L27; Validated; Region: rpmA; PRK05435
430066008709	50S ribosomal protein L21/unknown domain fusion protein; Provisional; Region: PRK12278
430066008710	50S ribosomal protein L21; Validated; Region: rplU; PRK05573
430066008711	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3316
430066008712	Integrase core domain; Region: rve; pfam00665
430066008713	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
430066008714	non-specific DNA binding site [nucleotide binding]; other site
430066008715	salt bridge; other site
430066008716	sequence-specific DNA binding site [nucleotide binding]; other site
430066008717	Cupin domain; Region: Cupin_2; cl17218
430066008718	Methyltransferase domain; Region: Methyltransf_31; pfam13847
430066008719	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
430066008720	S-adenosylmethionine binding site [chemical binding]; other site
430066008721	AzlC protein; Region: AzlC; pfam03591
430066008722	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3316
430066008723	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3316
430066008724	Integrase core domain; Region: rve; pfam00665
430066008725	Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739
430066008726	Peptidase family M23; Region: Peptidase_M23; pfam01551
430066008727	Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376
430066008728	L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734
430066008729	ATP-dependent chaperone ClpB; Region: chaperone_ClpB; TIGR03346
430066008730	Clp amino terminal domain; Region: Clp_N; pfam02861
430066008731	Clp amino terminal domain; Region: Clp_N; pfam02861
430066008732	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
430066008733	Walker A motif; other site
430066008734	ATP binding site [chemical binding]; other site
430066008735	Walker B motif; other site
430066008736	arginine finger; other site
430066008737	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
430066008738	Walker A motif; other site
430066008739	ATP binding site [chemical binding]; other site
430066008740	Walker B motif; other site
430066008741	C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431
430066008742	Domain of unknown function (DUF4167); Region: DUF4167; pfam13763
430066008743	protein-(glutamine-N5) methyltransferase, release factor-specific; Region: RF_mod_PrmC; TIGR03534
430066008744	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
430066008745	S-adenosylmethionine binding site [chemical binding]; other site
430066008746	peptide chain release factor 1; Validated; Region: prfA; PRK00591
430066008747	This domain is found in peptide chain release factors; Region: PCRF; smart00937
430066008748	RF-1 domain; Region: RF-1; pfam00472
430066008749	Signal transduction protein containing GAF and PtsI domains [Signal transduction mechanisms]; Region: PtsP; COG3605
430066008750	GAF domain; Region: GAF; pfam01590
430066008751	PEP-utilising enzyme, N-terminal; Region: PEP-utilisers_N; pfam05524
430066008752	PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391
430066008753	PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896
430066008754	aspartate kinase; Reviewed; Region: PRK06635
430066008755	AAK_AKii-LysC-BS: Amino Acid Kinase Superfamily (AAK), AKii; this CD includes the N-terminal catalytic aspartokinase (AK) domain of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis 168, and the lysine plus threonine-sensitive...; Region: AAK_AKii-LysC-BS; cd04261
430066008756	putative nucleotide binding site [chemical binding]; other site
430066008757	putative catalytic residues [active]
430066008758	putative Mg ion binding site [ion binding]; other site
430066008759	putative aspartate binding site [chemical binding]; other site
430066008760	ACT domains of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related proteins; Region: ACT_AKii-LysC-BS-like_1; cd04913
430066008761	putative allosteric regulatory site; other site
430066008762	ACT domains of the lysine-sensitive, aspartokinase (AK) isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related domains; Region: ACT_AKii-LysC-BS-like_2; cd04936
430066008763	putative allosteric regulatory residue; other site
430066008764	bifunctional 3-demethylubiquinone-9 3-methyltransferase/ 2-octaprenyl-6-hydroxy phenol methylase; Provisional; Region: PRK05134
430066008765	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
430066008766	S-adenosylmethionine binding site [chemical binding]; other site
430066008767	EamA-like transporter family; Region: EamA; pfam00892
430066008768	Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697
430066008769	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5319
430066008770	Predicted amidohydrolase [General function prediction only]; Region: COG0388
430066008771	Nit1, Nit 2, and related proteins, and the Nit1-like domain of NitFhit (class 10 nitrilases); Region: nit; cd07572
430066008772	putative active site [active]
430066008773	catalytic triad [active]
430066008774	dimer interface [polypeptide binding]; other site
430066008775	Glutaredoxin (GRX) family, GRX bacterial class 1 and 3 (b_1_3)-like subfamily; composed of bacterial GRXs, approximately 10 kDa in size, and proteins containing a GRX or GRX-like domain. GRX is a glutathione (GSH) dependent reductase, catalyzing the...; Region: GRX_GRXb_1_3_like; cd03418
430066008776	GSH binding site [chemical binding]; other site
430066008777	catalytic residues [active]
430066008778	Predicted amidophosphoribosyltransferases [General function prediction only]; Region: ComFC; COG1040
430066008779	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
430066008780	active site
430066008781	biotin biosynthesis protein BioC; Region: BioC; TIGR02072
430066008782	Methyltransferase domain; Region: Methyltransf_11; pfam08241
430066008783	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
430066008784	putative substrate translocation pore; other site
430066008785	Tellurite resistance protein TerB; Region: TerB; cl17311
430066008786	Tellurite resistance protein TerB; Region: TerB; cl17311
430066008787	Uncharacterized membrane-bound protein [Function unknown]; Region: COG3898
430066008788	HemY protein N-terminus; Region: HemY_N; pfam07219
430066008789	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4223
430066008790	Uroporphyrinogen-III synthase [Coenzyme metabolism]; Region: HemD; COG1587
430066008791	Uroporphyrinogen-III synthase (HemD) catalyzes the asymmetrical cyclization of tetrapyrrole (linear) to uroporphyrinogen-III, the fourth step in the biosynthesis of heme. This ubiquitous enzyme is present in eukaryotes, bacteria and archaea. Mutations in...; Region: HemD; cd06578
430066008792	active site
430066008793	porphobilinogen deaminase; Reviewed; Region: hemC; PRK00072
430066008794	Hydroxymethylbilane synthase (HMBS), also known as porphobilinogen deaminase (PBGD), is an intermediate enzyme in the biosynthetic pathway of tetrapyrrolic ring systems, such as heme, chlorophylls, and vitamin B12. HMBS catalyzes the conversion of...; Region: HMBS; cl17708
430066008795	domain interfaces; other site
430066008796	active site
430066008797	UGMP family protein; Validated; Region: PRK09604
430066008798	Inactive homolog of metal-dependent proteases, putative molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: COG1214; cl17884
430066008799	NAD(P)H-dependent glycerol-3-phosphate dehydrogenase; Validated; Region: gpsA; PRK00094
430066008800	NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210
430066008801	NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus; Region: NAD_Gly3P_dh_C; pfam07479
430066008802	YCII-related domain; Region: YCII; cl00999
430066008803	Uncharacterized conserved protein [Function unknown]; Region: COG2947
430066008804	Predicted methyltransferase [General function prediction only]; Region: COG3897
430066008805	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
430066008806	S-adenosylmethionine binding site [chemical binding]; other site
430066008807	Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697
430066008808	EamA-like transporter family; Region: EamA; pfam00892
430066008809	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167
430066008810	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
430066008811	DNA-binding site [nucleotide binding]; DNA binding site
430066008812	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
430066008813	pyridoxal 5'-phosphate binding site [chemical binding]; other site
430066008814	homodimer interface [polypeptide binding]; other site
430066008815	catalytic residue [active]
430066008816	Domain of unknown function (DUF4117); Region: DUF4117; pfam13491
430066008817	DNA segregation ATPase FtsK/SpoIIIE and related proteins [Cell division and chromosome partitioning]; Region: FtsK; COG1674
430066008818	FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580
430066008819	Ftsk gamma domain; Region: Ftsk_gamma; pfam09397
430066008820	Ammonia permease [Inorganic ion transport and metabolism]; Region: AmtB; COG0004
430066008821	Acyl-CoA thioesterase [Lipid metabolism]; Region: TesB; COG1946
430066008822	Thioesterase II (TEII) is thought to regenerate misprimed nonribosomal peptide synthetases (NRPSs) as well as modular polyketide synthases (PKSs) by hydrolyzing acetyl groups bound to the peptidyl carrier protein (PCP) and acyl carrier protein (ACP)...; Region: Thioesterase_II_repeat2; cd03445
430066008823	active site
430066008824	Thioesterase II (TEII) is thought to regenerate misprimed nonribosomal peptide synthetases (NRPSs) as well as modular polyketide synthases (PKSs) by hydrolyzing acetyl groups bound to the peptidyl carrier protein (PCP) and acyl carrier protein (ACP)...; Region: Thioesterase_II_repeat1; cd03444
430066008825	catalytic triad [active]
430066008826	dimer interface [polypeptide binding]; other site
430066008827	2-octaprenyl-6-methoxyphenyl hydroxylase; Provisional; Region: PRK07333
430066008828	ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314
430066008829	This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_19; cd07262
430066008830	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
430066008831	succinate dehydrogenase iron-sulfur subunit; Reviewed; Region: sdhB; PRK05950
430066008832	2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_3; pfam13085
430066008833	succinate dehydrogenase flavoprotein subunit; Reviewed; Region: sdhA; PRK09078
430066008834	L-aspartate oxidase; Provisional; Region: PRK06175
430066008835	Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910
430066008836	Succinate:quinone oxidoreductase (SQR) Type C subfamily, Succinate dehydrogenase D (SdhD) subunit-like; composed of predominantly uncharacterized bacterial proteins with similarity to the E. coli SdhD subunit. One characterized protein is the respiratory...; Region: SQR_TypeC_SdhD_like; cd03495
430066008837	putative SdhC subunit interface [polypeptide binding]; other site
430066008838	putative proximal heme binding site [chemical binding]; other site
430066008839	putative Iron-sulfur protein interface [polypeptide binding]; other site
430066008840	putative proximal quinone binding site; other site
430066008841	Succinate:quinone oxidoreductase (SQR) Type C subfamily, Succinate dehydrogenase C (SdhC) subunit; composed of bacterial SdhC and eukaryotic large cytochrome b binding (CybL) proteins. SQR catalyzes the oxidation of succinate to fumarate coupled to the...; Region: SQR_TypeC_SdhC; cd03499
430066008842	Iron-sulfur protein interface; other site
430066008843	proximal quinone binding site [chemical binding]; other site
430066008844	SdhD (CybS) interface [polypeptide binding]; other site
430066008845	proximal heme binding site [chemical binding]; other site
430066008846	NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961
430066008847	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
430066008848	Coenzyme A binding pocket [chemical binding]; other site
430066008849	3-isopropylmalate dehydratase large subunit; Reviewed; Region: PRK00402
430066008850	3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate; Region: IPMI; cd01583
430066008851	substrate binding site [chemical binding]; other site
430066008852	ligand binding site [chemical binding]; other site
430066008853	50S ribosomal protein L19; Provisional; Region: rplS; PRK05338
430066008854	Cytosine/uracil/thiamine/allantoin permeases [Nucleotide transport and metabolism / Coenzyme metabolism]; Region: FUI1; COG1953
430066008855	Na binding site [ion binding]; other site
430066008856	Uncharacterized enzyme involved in biosynthesis of extracellular polysaccharides [General function prediction only]; Region: COG2329
430066008857	NIPSNAP; Region: NIPSNAP; pfam07978
430066008858	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
430066008859	dimerization interface [polypeptide binding]; other site
430066008860	putative DNA binding site [nucleotide binding]; other site
430066008861	putative Zn2+ binding site [ion binding]; other site
430066008862	tRNA (guanine-N(1)-)-methyltransferase; Reviewed; Region: trmD; PRK00026
430066008863	16S rRNA-processing protein RimM; Provisional; Region: rimM; PRK00122
430066008864	RimM N-terminal domain; Region: RimM; pfam01782
430066008865	PRC-barrel domain; Region: PRC; pfam05239
430066008866	site-specific tyrosine recombinase XerC; Reviewed; Region: xerC; PRK00236
430066008867	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
430066008868	active site
430066008869	DNA binding site [nucleotide binding]
430066008870	Int/Topo IB signature motif; other site
430066008871	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3735
430066008872	dihydrolipoamide dehydrogenase; Validated; Region: PRK06327
430066008873	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
430066008874	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
430066008875	Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852
430066008876	Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280
430066008877	Predicted membrane protein [Function unknown]; Region: COG3686
430066008878	dihydrolipoamide succinyltransferase; Validated; Region: PRK05704
430066008879	Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849
430066008880	E3 interaction surface; other site
430066008881	lipoyl attachment site [posttranslational modification]; other site
430066008882	e3 binding domain; Region: E3_binding; pfam02817
430066008883	2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198
430066008884	2-oxoglutarate dehydrogenase E1 component; Reviewed; Region: sucA; PRK09404
430066008885	Thiamine pyrophosphate (TPP) family, E1 of OGDC-like subfamily, TPP-binding module; composed of proteins similar to the E1 component of the 2-oxoglutarate dehydrogenase multienzyme complex (OGDC). OGDC catalyzes the oxidative decarboxylation of...; Region: TPP_E1_OGDC_like; cd02016
430066008886	TPP-binding site [chemical binding]; other site
430066008887	Transketolase, pyrimidine binding domain; Region: Transket_pyr; pfam02779
430066008888	succinyl-CoA synthetase subunit alpha; Validated; Region: PRK05678
430066008889	CoA binding domain; Region: CoA_binding; smart00881
430066008890	CoA-ligase; Region: Ligase_CoA; pfam00549
430066008891	succinyl-CoA synthetase subunit beta; Provisional; Region: sucC; PRK00696
430066008892	ATP-grasp domain; Region: ATP-grasp_2; pfam08442
430066008893	CoA-ligase; Region: Ligase_CoA; pfam00549
430066008894	malate dehydrogenase; Reviewed; Region: PRK06223
430066008895	L-lactate dehydrogenase-like malate dehydrogenase proteins; Region: LDH-like_MDH; cd01339
430066008896	NAD(P) binding site [chemical binding]; other site
430066008897	dimer interface [polypeptide binding]; other site
430066008898	tetramer (dimer of dimers) interface [polypeptide binding]; other site
430066008899	substrate binding site [chemical binding]; other site
430066008900	Predicted ATPase [General function prediction only]; Region: COG1485
430066008901	Protease inhibitor Inh; Region: Inh; pfam02974
430066008902	diaminopimelate epimerase; Provisional; Region: dapF; PRK00450
430066008903	Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678
430066008904	Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678
430066008905	Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919
430066008906	MiaB-like tRNA modifying enzyme; Region: MiaB-like-C; TIGR01579
430066008907	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
430066008908	FeS/SAM binding site; other site
430066008909	signal recognition particle-docking protein FtsY; Provisional; Region: PRK10416
430066008910	SRP54-type protein, helical bundle domain; Region: SRP54_N; smart00963
430066008911	The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203
430066008912	intracellular septation protein A; Reviewed; Region: PRK00259
430066008913	hydroxyacylglutathione hydrolase; Region: GSH_gloB; TIGR03413
430066008914	The MutT pyrophosphohydrolase is a prototypical Nudix hydrolase that catalyzes the hydrolysis of nucleoside and deoxynucleoside triphosphates (NTPs and dNTPs) by substitution at a beta-phosphorus to yield a nucleotide monophosphate (NMP) and inorganic...; Region: MutT_pyrophosphohydrolase; cd03425
430066008915	active site
430066008916	8-oxo-dGMP binding site [chemical binding]; other site
430066008917	nudix motif; other site
430066008918	metal binding site [ion binding]; metal-binding site
430066008919	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
430066008920	Coenzyme A binding pocket [chemical binding]; other site
430066008921	Ornithine acetyltransferase (OAT) family; also referred to as ArgJ. OAT catalyzes the first and fifth steps in arginine biosynthesis, coupling acetylation of glutamate with deacetylation of N-acetylornithine, which allows recycling of the acetyl group in...; Region: OAT; cd02152
430066008922	heterotetramer interface [polypeptide binding]; other site
430066008923	active site pocket [active]
430066008924	cleavage site
430066008925	peptidylprolyl isomerase; Reviewed; Region: prsA; PRK03002
430066008926	PPIC-type PPIASE domain; Region: Rotamase; pfam00639
430066008927	preprotein translocase subunit SecA; Reviewed; Region: PRK12904
430066008928	DEAD/DEAH box helicase; Region: DEAD; pfam00270
430066008929	ATP binding site [chemical binding]; other site
430066008930	putative Mg++ binding site [ion binding]; other site
430066008931	SecA preprotein cross-linking domain; Region: SecA_PP_bind; smart00958
430066008932	SEC-C motif; Region: SEC-C; pfam02810
430066008933	Protein involved in cellulose biosynthesis (CelD) [Cell envelope biogenesis, outer membrane]; Region: COG5653
430066008934	Acetyltransferase (GNAT) domain; Region: Acetyltransf_6; pfam13480
430066008935	Predicted membrane-associated, metal-dependent hydrolase [General function prediction only]; Region: COG2194
430066008936	Domain of unknown function (DUF1705); Region: DUF1705; pfam08019
430066008937	Sulfatase; Region: Sulfatase; cl17466
430066008938	Sulfatase; Region: Sulfatase; pfam00884
430066008939	Transcriptional regulator [Transcription]; Region: LysR; COG0583
430066008940	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
430066008941	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466
430066008942	dimerization interface [polypeptide binding]; other site
430066008943	Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497
430066008944	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
430066008945	substrate binding pocket [chemical binding]; other site
430066008946	membrane-bound complex binding site; other site
430066008947	hinge residues; other site
430066008948	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427
430066008949	ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215
430066008950	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
430066008951	dimer interface [polypeptide binding]; other site
430066008952	conserved gate region; other site
430066008953	putative PBP binding loops; other site
430066008954	ABC-ATPase subunit interface; other site
430066008955	ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126
430066008956	ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262
430066008957	Walker A/P-loop; other site
430066008958	ATP binding site [chemical binding]; other site
430066008959	Q-loop/lid; other site
430066008960	ABC transporter signature motif; other site
430066008961	Walker B; other site
430066008962	D-loop; other site
430066008963	H-loop/switch region; other site
430066008964	agmatinase; Region: agmatinase; TIGR01230
430066008965	Agmatinase and related proteins; Region: Agmatinase_like_1; cd11589
430066008966	oligomer interface [polypeptide binding]; other site
430066008967	active site
430066008968	Mn binding site [ion binding]; other site
430066008969	aspartate ammonia-lyase; Provisional; Region: aspA; PRK12273
430066008970	Aspartase; Region: Aspartase; cd01357
430066008971	active sites [active]
430066008972	tetramer interface [polypeptide binding]; other site
430066008973	ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126
430066008974	ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262
430066008975	Walker A/P-loop; other site
430066008976	ATP binding site [chemical binding]; other site
430066008977	Q-loop/lid; other site
430066008978	ABC transporter signature motif; other site
430066008979	Walker B; other site
430066008980	D-loop; other site
430066008981	H-loop/switch region; other site
430066008982	Type II (periplasmic) bacterial L-asparaginase; Region: L-asparaginase_II; cd08964
430066008983	active site
430066008984	homotetramer interface [polypeptide binding]; other site
430066008985	homodimer interface [polypeptide binding]; other site
430066008986	Transcriptional regulators [Transcription]; Region: GntR; COG1802
430066008987	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
430066008988	DNA-binding site [nucleotide binding]; DNA binding site
430066008989	FCD domain; Region: FCD; pfam07729
430066008990	Type II (periplasmic) bacterial L-asparaginase; Region: L-asparaginase_II; cd08964
430066008991	active site
430066008992	homotetramer interface [polypeptide binding]; other site
430066008993	homodimer interface [polypeptide binding]; other site
430066008994	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
430066008995	D-galactonate transporter; Region: 2A0114; TIGR00893
430066008996	putative substrate translocation pore; other site
430066008997	methionine gamma-lyase; Validated; Region: PRK07049
430066008998	CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614
430066008999	homodimer interface [polypeptide binding]; other site
430066009000	substrate-cofactor binding pocket; other site
430066009001	pyridoxal 5'-phosphate binding site [chemical binding]; other site
430066009002	catalytic residue [active]
430066009003	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
430066009004	Ligand Binding Site [chemical binding]; other site
430066009005	Tryptophan synthase beta superfamily (fold type II); this family of pyridoxal phosphate (PLP)-dependent enzymes catalyzes beta-replacement and beta-elimination reactions. This CD corresponds to aminocyclopropane-1-carboxylate deaminase (ACCD), tryptophan...; Region: Trp-synth-beta_II; cl00342
430066009006	catalytic residue [active]
430066009007	CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561
430066009008	pyridoxal 5'-phosphate binding site [chemical binding]; other site
430066009009	3-hydroxybutyryl-CoA dehydrogenase; Validated; Region: PRK07530
430066009010	3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737
430066009011	3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725
430066009012	Electron transfer flavoprotein, alpha subunit [Energy production and conversion]; Region: FixB; COG2025
430066009013	The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_alpha; cd01715
430066009014	Electron transfer flavoprotein FAD-binding domain; Region: ETF_alpha; pfam00766
430066009015	The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_beta; cd01714
430066009016	Ligand binding site [chemical binding]; other site
430066009017	Electron transfer flavoprotein domain; Region: ETF; pfam01012
430066009018	ExsB is a transcription regulator related protein. It is a subfamily of a Adenosine nucleotide binding superfamily of proteins. This protein family is represented by a single member in nearly every completed large (> 1000 genes) prokaryotic genome. In...; Region: ExsB; cd01995
430066009019	Ligand Binding Site [chemical binding]; other site
430066009020	6-pyruvoyl-tetrahydropterin synthase [Coenzyme metabolism]; Region: COG0720
430066009021	active site
430066009022	7-cyano-7-deazaguanosine (preQ0) biosynthesis protein QueE; Region: Bsubt_queE; TIGR03365
430066009023	cob(I)alamin adenosyltransferase [Coenzyme transport and    metabolism]; Region: COG2096
430066009024	Hypoxia induced protein conserved region; Region: HIG_1_N; pfam04588
430066009025	short chain dehydrogenase; Provisional; Region: PRK05993
430066009026	17beta hydroxysteroid dehydrogenase-like, classical (c) SDRs; Region: 17beta-HSD-like_SDR_c; cd05374
430066009027	NADP binding site [chemical binding]; other site
430066009028	active site
430066009029	steroid binding site; other site
430066009030	Ribonuclease BN family enzyme [Replication, recombination, and repair]; Region: Rbn; COG1295
430066009031	hypothetical protein; Validated; Region: PRK00124
430066009032	TlpA-like family; composed of  TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966
430066009033	Thioredoxin-like; Region: Thioredoxin_8; pfam13905
430066009034	catalytic residues [active]
430066009035	argininosuccinate lyase; Provisional; Region: PRK00855
430066009036	Argininosuccinate lyase (argininosuccinase, ASAL); Region: Argininosuccinate_lyase; cd01359
430066009037	active sites [active]
430066009038	tetramer interface [polypeptide binding]; other site
430066009039	Predicted small periplasmic lipoprotein [Cell motility and secretion]; Region: COG5567
430066009040	Diaminopimelate decarboxylase [Amino acid transport and metabolism]; Region: LysA; COG0019
430066009041	Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Diaminopimelate Decarboxylase; Region: PLPDE_III_DapDC; cd06828
430066009042	active site
430066009043	pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site
430066009044	substrate binding site [chemical binding]; other site
430066009045	catalytic residues [active]
430066009046	dimer interface [polypeptide binding]; other site
430066009047	TIGR02302 family protein; Region: aProt_lowcomp
430066009048	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
430066009049	active site
430066009050	Methyltransferase domain; Region: Methyltransf_23; pfam13489
430066009051	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
430066009052	histidinol-phosphate aminotransferase; Validated; Region: PRK02731
430066009053	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
430066009054	pyridoxal 5'-phosphate binding site [chemical binding]; other site
430066009055	homodimer interface [polypeptide binding]; other site
430066009056	catalytic residue [active]
430066009057	cyclohexadienyl dehydrogenase; Validated; Region: PRK07502
430066009058	prephenate dehydrogenase; Validated; Region: PRK08507
430066009059	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4093
430066009060	Uncharacterized protein conserved in bacteria (DUF2125); Region: DUF2125; pfam09898
430066009061	Uncharacterized protein involved in cation transport [Inorganic ion transport and metabolism]; Region: ChaC; COG3703
430066009062	GGCT-like domains, also called AIG2-like family. Gamma-glutamyl cyclotransferase (GGCT) catalyzes the formation of pyroglutamic acid (5-oxoproline) from dipeptides containing gamma-glutamyl, and is a dimeric protein. In Homo sapiens, the protein is...; Region: GGCT_like; cd06661
430066009063	putative active site pocket [active]
430066009064	dimerization interface [polypeptide binding]; other site
430066009065	putative catalytic residue [active]
430066009066	YGGT family; Region: YGGT; pfam02325
430066009067	Inorganic pyrophosphatase. These enzymes hydrolyze inorganic pyrophosphate (PPi) to two molecules of orthophosphates (Pi). The reaction requires bivalent cations. The enzymes in general exist as homooligomers; Region: pyrophosphatase; cd00412
430066009068	dimer interface [polypeptide binding]; other site
430066009069	substrate binding site [chemical binding]; other site
430066009070	metal binding sites [ion binding]; metal-binding site
430066009071	1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204
430066009072	Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989
430066009073	putative acyl-acceptor binding pocket; other site
430066009074	Uncharacterized conserved protein [Function unknown]; Region: COG1434
430066009075	YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259
430066009076	putative active site [active]
430066009077	Cell division protein [Cell division and chromosome partitioning]; Region: FtsX; COG2177
430066009078	Predicted ATPase involved in cell division [Cell division and chromosome partitioning]; Region: FtsE; COG2884
430066009079	ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255
430066009080	Walker A/P-loop; other site
430066009081	ATP binding site [chemical binding]; other site
430066009082	Q-loop/lid; other site
430066009083	ABC transporter signature motif; other site
430066009084	Walker B; other site
430066009085	D-loop; other site
430066009086	H-loop/switch region; other site
430066009087	Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane channels that selectively transport water, small neutral molecules, and ions out of and between cells. The channel proteins share a common fold: the N-terminal...; Region: MIP; cd00333
430066009088	amphipathic channel; other site
430066009089	Asn-Pro-Ala signature motifs; other site
430066009090	Outer membrane lipoprotein-sorting protein [Cell envelope biogenesis, outer membrane]; Region: LolA; COG2834
430066009091	Outer membrane lipoprotein carrier protein LolA; Region: LolA; pfam03548
430066009092	Escherichia coli exonuclease III (ExoIII) and Neisseria meningitides NExo-like subfamily of the ExoIII family purinic/apyrimidinic (AP) endonucleases; Region: ExoIII-like_AP-endo; cd09086
430066009093	putative catalytic site [active]
430066009094	putative phosphate binding site [ion binding]; other site
430066009095	active site
430066009096	metal binding site A [ion binding]; metal-binding site
430066009097	DNA binding site [nucleotide binding]
430066009098	putative AP binding site [nucleotide binding]; other site
430066009099	putative metal binding site B [ion binding]; other site
430066009100	cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664
430066009101	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
430066009102	ligand binding site [chemical binding]; other site
430066009103	flexible hinge region; other site
430066009104	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
430066009105	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
430066009106	active site
430066009107	phosphorylation site [posttranslational modification]
430066009108	intermolecular recognition site; other site
430066009109	dimerization interface [polypeptide binding]; other site
430066009110	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
430066009111	DNA binding site [nucleotide binding]
430066009112	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3786
430066009113	Bacterial Ig-like domain (group 1); Region: Big_1; cl17740
430066009114	putative lipoprotein/autotransporter domain-containing protein; Provisional; Region: PRK14849
430066009115	Type V secretory pathway, adhesin AidA [Cell envelope biogenesis, outer membrane / Intracellular trafficking and secretion]; Region: AidA; COG3468
430066009116	Pertactin-like passenger domains (virulence factors), C-terminal, subgroup 2, of autotransporter proteins of the type V secretion system of Gram-negative bacteria. This subgroup includes the passenger domains of the nonprotease autotransporters, Ag43; Region: PL2_Passenger_AT; cd01344
430066009117	Autotransporter beta-domain; Region: Autotransporter; smart00869
430066009118	Uncharacterized member of the PurR regulon [General function prediction only]; Region: yhhQ; COG1738
430066009119	50S ribosomal protein L28; Reviewed; Region: rpmB; PRK00359
430066009120	Protein of unknown function (DUF3108); Region: DUF3108; pfam11306
430066009121	Helix-Turn-Helix DNA binding domain of the CadR- and PbrR-like transcription regulators; Region: HTH_CadR-PbrR-like; cd04785
430066009122	DNA binding residues [nucleotide binding]
430066009123	zinc-responsive transcriptional regulator; Provisional; Region: zntR; PRK09514
430066009124	dimer interface [polypeptide binding]; other site
430066009125	putative metal binding site [ion binding]; other site
430066009126	Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371
430066009127	metal-binding site [ion binding]
430066009128	Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217
430066009129	Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371
430066009130	metal-binding site [ion binding]
430066009131	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
430066009132	Soluble P-type ATPase [General function prediction only]; Region: COG4087
430066009133	Cobalamin biosynthesis protein CobT (nicotinate-mononucleotide:5, 6-dimethylbenzimidazole phosphoribosyltransferase) [Coenzyme metabolism]; Region: CobT; COG4547
430066009134	Cobalamin biosynthesis protein CobT; Region: CobT; pfam06213
430066009135	norD type: Denitrifying bacteria contain both membrane bound and periplasmic nitrate reductases. Denitrification plays a major role  in completing the nitrogen cycle by converting nitrate or nitrite to nitrogen gas. The pathway for microbial...; Region: vWA_norD_type; cd01454
430066009136	metal ion-dependent adhesion site (MIDAS); other site
430066009137	cobaltochelatase, CobS subunit; Region: PD_CobS; TIGR01650
430066009138	Cobaltochelatase CobS subunit N terminal; Region: CobS_N; pfam12556
430066009139	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189
430066009140	DnaJ-class molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: CbpA; COG2214
430066009141	DnaJ domain or J-domain.  DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257
430066009142	HSP70 interaction site [polypeptide binding]; other site
430066009143	Stress-induced morphogen (activity unknown) [Signal transduction mechanisms]; Region: BolA; COG0271
430066009144	Putative Mg2+ and Co2+ transporter CorB [Inorganic ion transport and metabolism]; Region: CorB; COG4536
430066009145	Domain of unknown function DUF21; Region: DUF21; pfam01595
430066009146	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590
430066009147	Transporter associated domain; Region: CorC_HlyC; smart01091
430066009148	Dehydroquinate synthase (DHQS) catalyzes the conversion of DAHP to DHQ in shikimate pathway for aromatic compounds synthesis; Region: DHQS; cd08195
430066009149	Iron-containing alcohol dehydrogenase; Region: Fe-ADH; pfam00465
430066009150	active site
430066009151	dimer interface [polypeptide binding]; other site
430066009152	metal binding site [ion binding]; metal-binding site
430066009153	Shikimate kinase [Amino acid transport and metabolism]; Region: AroK; COG0703
430066009154	Shikimate kinase (SK) is the fifth enzyme in the shikimate pathway, a seven-step biosynthetic pathway which converts erythrose-4-phosphate to chorismic acid, found in bacteria, fungi and plants. Chorismic acid is a important intermediate in the synthesis...; Region: SK; cd00464
430066009155	ADP binding site [chemical binding]; other site
430066009156	magnesium binding site [ion binding]; other site
430066009157	putative shikimate binding site; other site
430066009158	site-specific tyrosine recombinase XerD; Reviewed; Region: xerD; PRK00283
430066009159	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
430066009160	active site
430066009161	DNA binding site [nucleotide binding]
430066009162	Int/Topo IB signature motif; other site
430066009163	acetyl-CoA carboxylase carboxyltransferase subunit alpha; Validated; Region: PRK05724
430066009164	acetyl-CoA carboxylase carboxyltransferase alpha subunit; Provisional; Region: accA; CHL00198
430066009165	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3034
430066009166	SirA, YedF, and YeeD. Two-layered alpha/beta sandwich domain.  SirA (also known as UvrY,  and YhhP) belongs to a family of bacterial two-component response regulators that controls secondary metabolism and virulence. The other member of this...; Region: SirA_YedF_YeeD; cd00291
430066009167	CPxP  motif; other site
430066009168	Putative GTPases (G3E family) [General function prediction only]; Region: COG0523
430066009169	The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203
430066009170	Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; pfam07683
430066009171	D-alanyl-D-alanine carboxypeptidase; Region: Peptidase_S11; pfam00768
430066009172	Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872
430066009173	Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473
430066009174	M20 Peptidase Aminoacylase 1 subfamily; Region: M20_Acy1_like1; cd05666
430066009175	metal binding site [ion binding]; metal-binding site
430066009176	putative dimer interface [polypeptide binding]; other site
430066009177	3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557
430066009178	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
430066009179	NAD(P) binding site [chemical binding]; other site
430066009180	active site
430066009181	Uncharacterized conserved protein [Function unknown]; Region: COG3791
430066009182	Domain of unknown function (DUF4354); Region: DUF4354; pfam14263
430066009183	choline dehydrogenase; Validated; Region: PRK02106
430066009184	GMC oxidoreductase; Region: GMC_oxred_C; pfam05199
430066009185	3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: PRK12745
430066009186	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
430066009187	NAD(P) binding site [chemical binding]; other site
430066009188	active site
430066009189	Choline dehydrogenase and related flavoproteins [Amino acid transport and metabolism]; Region: BetA; COG2303
430066009190	GMC oxidoreductase; Region: GMC_oxred_C; pfam05199
430066009191	Aldehyde dehydrogenase family; Region: Aldedh; pfam00171
430066009192	Gluconobacter oxydans L-sorbosone dehydrogenase-like; Region: ALDH_SNDH; cd07118
430066009193	NAD(P) binding site [chemical binding]; other site
430066009194	catalytic residues [active]
430066009195	Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024
430066009196	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
430066009197	substrate binding site [chemical binding]; other site
430066009198	oxyanion hole (OAH) forming residues; other site
430066009199	trimer interface [polypeptide binding]; other site
430066009200	Coenzyme A transferase; Region: CoA_trans; smart00882
430066009201	Coenzyme A transferase; Region: CoA_trans; cl17247
430066009202	Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673
430066009203	Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408
430066009204	Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894
430066009205	Transcriptional regulators [Transcription]; Region: PurR; COG1609
430066009206	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
430066009207	DNA binding site [nucleotide binding]
430066009208	domain linker motif; other site
430066009209	Ligand-binding domain of MalI, a transcription regulator of the maltose system of Escherichia coli and its close homologs from other bacteria; Region: PBP1_MalI_like; cd06289
430066009210	putative dimerization interface [polypeptide binding]; other site
430066009211	putative ligand binding site [chemical binding]; other site
430066009212	Protein of unknown function (DUF993); Region: DUF993; pfam06187
430066009213	probable oxidoreductase, LLM family; Region: LLM_2I7G; TIGR03858
430066009214	Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases [Energy production and conversion]; Region: COG2141
430066009215	Type I periplasmic ligand-binding domain of uncharacterized ABC-type transport systems that are predicted to be involved in the uptake of amino acids, peptides, or inorganic ions; Region: PBP1_ABC_uncharacterized_transporter; cd06325
430066009216	Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407
430066009217	zinc binding site [ion binding]; other site
430066009218	putative ligand binding site [chemical binding]; other site
430066009219	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
430066009220	Transmembrane subunit (TM) of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which are involved in the uptake of branched-chain amino acids (AAs), as well as TMs of transporters involved in the uptake of...; Region: TM_PBP1_branched-chain-AA_like; cd06574
430066009221	TM-ABC transporter signature motif; other site
430066009222	ABC-type uncharacterized transport system, ATPase component [General function prediction only]; Region: PhnK; COG1101
430066009223	First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225
430066009224	Walker A/P-loop; other site
430066009225	ATP binding site [chemical binding]; other site
430066009226	Q-loop/lid; other site
430066009227	ABC transporter signature motif; other site
430066009228	Walker B; other site
430066009229	D-loop; other site
430066009230	H-loop/switch region; other site
430066009231	DNA polymerase III subunit delta; Reviewed; Region: holA; PRK06585
430066009232	DNA polymerase III, delta subunit; Region: DNA_pol3_delta; pfam06144
430066009233	Stage 0 sporulation protein J (antagonist of Soj) containing ParB-like nuclease domain [Transcription]; Region: Spo0J; COG1475
430066009234	ParB-like nuclease domain; Region: ParB; smart00470
430066009235	ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192
430066009236	ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042
430066009237	P-loop; other site
430066009238	Magnesium ion binding site [ion binding]; other site
430066009239	ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042
430066009240	Magnesium ion binding site [ion binding]; other site
430066009241	Predicted S-adenosylmethionine-dependent methyltransferase involved in bacterial cell division [Cell envelope biogenesis, outer membrane]; Region: GidB; COG0357
430066009242	16S rRNA methyltransferase GidB; Reviewed; Region: gidB; PRK00107
430066009243	tRNA uridine 5-carboxymethylaminomethyl modification enzyme GidA; Validated; Region: PRK05192
430066009244	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
430066009245	NAD(FAD)-utilizing enzyme possibly involved in translation [Translation, ribosomal structure and biogenesis]; Region: Gid; COG1206
430066009246	GidA associated domain 3; Region: GIDA_assoc_3; pfam13932
430066009247	Predicted GTPase [General function prediction only]; Region: ThdF; COG0486
430066009248	GTP-binding protein TrmE N-terminus; Region: TrmE_N; pfam10396
430066009249	Circularly permuted YlqF-related GTPases; Region: YlqF_related_GTPase; cl17249
430066009250	trmE is a tRNA modification GTPase; Region: trmE; cd04164
430066009251	G1 box; other site
430066009252	G1 box; other site
430066009253	GTP/Mg2+ binding site [chemical binding]; other site
430066009254	GTP/Mg2+ binding site [chemical binding]; other site
430066009255	Switch I region; other site
430066009256	Switch I region; other site
430066009257	G2 box; other site
430066009258	G2 box; other site
430066009259	Switch II region; other site
430066009260	G3 box; other site
430066009261	G4 box; other site
430066009262	G5 box; other site
430066009263	Catalytic cysteine-containing C-terminus of GTPase, MnmE; Region: GTPase_Cys_C; pfam12631
430066009264	Highly conserved protein containing a thioredoxin domain [Posttranslational modification, protein turnover, chaperones]; Region: COG1331
430066009265	TRX domain, SSP411 protein family; members of this family are highly conserved proteins present in eukaryotes, bacteria and archaea, about 600-800 amino acids in length, which contain a TRX domain with a redox active CXXC motif. The human/rat protein; Region: SSP411; cd02955
430066009266	catalytic residues [active]
430066009267	This group contains class II terpene cyclases, protein prenyltransferases beta subunit, two broadly specific proteinase inhibitors alpha2-macroglobulin (alpha (2)-M) and pregnancy zone protein (PZP) and, the C3 C4 and C5 components of vertebrate...; Region: ISOPREN_C2_like; cl08267
430066009268	transcription termination factor Rho; Provisional; Region: rho; PRK09376
430066009269	Rho termination factor, N-terminal domain; Region: Rho_N; smart00959
430066009270	Rho_CSD: Rho protein cold-shock domain (CSD). Rho protein is a transcription termination factor in most bacteria. In bacteria, there are two distinct mechanisms for mRNA transcription termination. In intrinsic termination, RNA polymerase and nascent mRNA...; Region: Rho_CSD; cd04459
430066009271	RNA binding site [nucleotide binding]; other site
430066009272	Transcription termination factor rho is a bacterial ATP-dependent RNA/DNA helicase. It is a homohexamer. Each monomer consists of an N-terminal domain of the OB fold, which is responsible for binding to cysteine rich nucleotides. This alignment is of the...; Region: rho_factor; cd01128
430066009273	multimer interface [polypeptide binding]; other site
430066009274	Walker A motif; other site
430066009275	ATP binding site [chemical binding]; other site
430066009276	Walker B motif; other site
430066009277	Predicted membrane protein [Function unknown]; Region: COG1981
430066009278	Uroporphyrinogen decarboxylase (URO-D) is a dimeric cytosolic enzyme that decarboxylates the four acetate side chains of uroporphyrinogen III (uro-III) to create coproporphyrinogen III, without requiring any prosthetic groups or cofactors. This reaction...; Region: URO-D; cd00717
430066009279	substrate binding site [chemical binding]; other site
430066009280	active site
430066009281	PEP synthetase regulatory protein; Provisional; Region: PRK05339
430066009282	Maf-like protein; Reviewed; Region: PRK00078
430066009283	Nucleotide binding protein Maf. Maf has been implicated in inhibition of septum formation in eukaryotes, bacteria and archaea, but homologs in B.subtilis and S.cerevisiae are nonessential for cell division. Maf has been predicted to be a nucleotide- or...; Region: Maf; cd00555
430066009284	active site
430066009285	dimer interface [polypeptide binding]; other site
430066009286	shikimate 5-dehydrogenase; Reviewed; Region: aroE; PRK00258
430066009287	Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501
430066009288	NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065
430066009289	shikimate binding site; other site
430066009290	NAD(P) binding site [chemical binding]; other site
430066009291	Dephospho-CoA kinase [Coenzyme metabolism]; Region: CoaE; COG0237
430066009292	Dephospho-coenzyme A kinase (DPCK, EC 2.7.1.24) catalyzes the phosphorylation of dephosphocoenzyme A (dCoA) to yield CoA, which is the final step in CoA biosynthesis; Region: DPCK; cd02022
430066009293	CoA-binding site [chemical binding]; other site
430066009294	ATP-binding [chemical binding]; other site
430066009295	DNA polymerase III, epsilon subunit, Proteobacterial; Region: dnaQ_proteo; TIGR01406
430066009296	DEDDh 3'-5' exonuclease domain of the epsilon subunit of Escherichia coli DNA polymerase III and similar proteins; Region: DNA_pol_III_epsilon_Ecoli_like; cd06131
430066009297	active site
430066009298	catalytic site [active]
430066009299	substrate binding site [chemical binding]; other site
430066009300	preprotein translocase subunit SecB; Validated; Region: PRK05751
430066009301	SecA binding site; other site
430066009302	Preprotein binding site; other site
430066009303	Protein affecting phage T7 exclusion by the F plasmid [General function prediction only]; Region: FxsA; COG3030
430066009304	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4395
430066009305	Membrane-bound lytic murein transglycosylase [Cell envelope biogenesis, outer membrane]; Region: MltA; COG2821
430066009306	MltA specific insert domain; Region: MltA; pfam03562
430066009307	3D domain; Region: 3D; pfam06725
430066009308	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2840
430066009309	Smr domain; Region: Smr; pfam01713
430066009310	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
430066009311	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
430066009312	sequence-specific DNA binding site [nucleotide binding]; other site
430066009313	salt bridge; other site
430066009314	Protein of unknown function (DUF1402); Region: DUF1402; pfam07182
430066009315	ATP-dependent protease ATP-binding subunit HslU; Provisional; Region: hslU; PRK05201
430066009316	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
430066009317	Walker A motif; other site
430066009318	ATP binding site [chemical binding]; other site
430066009319	AAA domain (Cdc48 subfamily); Region: AAA_2; pfam07724
430066009320	C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086
430066009321	Protease HslV and the ATPase/chaperone HslU are part of an ATP-dependent proteolytic system that is the prokaryotic homolog of the proteasome. HslV is a dimer of hexamers (a dodecamer) that forms a central proteolytic chamber with active sites on the...; Region: protease_HslV; cd01913
430066009322	active site
430066009323	HslU subunit interaction site [polypeptide binding]; other site
430066009324	Imidazoleglycerol-phosphate dehydratase; Region: IGPD; cd07914
430066009325	putative active site pocket [active]
430066009326	4-fold oligomerization interface [polypeptide binding]; other site
430066009327	metal binding residues [ion binding]; metal-binding site
430066009328	3-fold/trimer interface [polypeptide binding]; other site
430066009329	Protein of unknown function (DUF2628); Region: DUF2628; pfam10947
430066009330	imidazole glycerol phosphate synthase subunit HisH; Provisional; Region: hisH; PRK13146
430066009331	Type 1 glutamine amidotransferase (GATase1) domain found in imidazole glycerol phosphate synthase (IGPS); Region: GATase1_IGP_Synthase; cd01748
430066009332	putative active site [active]
430066009333	oxyanion strand; other site
430066009334	catalytic triad [active]
430066009335	HisA.  Phosphoribosylformimino-5-aminoimidazole carboxamide ribonucleotide (ProFAR) isomerase catalyzes the fourth step in histidine biosynthesis, an isomerisation of the aminoaldose moiety of ProFAR to the aminoketose of PRFAR (N-(5'-phospho-D-1...; Region: HisA; cd04732
430066009336	Histidine biosynthesis protein; Region: His_biosynth; pfam00977
430066009337	catalytic residues [active]
430066009338	The cyclase subunit of imidazoleglycerol phosphate synthase (HisF). Imidazole glycerol phosphate synthase (IGPS) catalyzes the fifth step of histidine biosynthesis, the formation of the imidazole ring. IGPS converts N1-(5'-phosphoribulosyl)...; Region: HisF; cd04731
430066009339	Histidine biosynthesis protein; Region: His_biosynth; pfam00977
430066009340	substrate binding site [chemical binding]; other site
430066009341	glutamase interaction surface [polypeptide binding]; other site
430066009342	Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in Escherichia coli phosphoribosyl-ATP pyrophosphohydrolase (HisIE or PRATP-PH) and its homologs; Region: NTP-PPase_HisIE_like; cd11534
430066009343	metal binding site [ion binding]; metal-binding site
430066009344	pantothenate kinase; Provisional; Region: PRK05439
430066009345	Pantothenate kinase (PanK) catalyzes the phosphorylation of pantothenic acid to form 4'-phosphopantothenic, which is the first of five steps in coenzyme A (CoA) biosynthetic pathway. The reaction carried out by this enzyme is a key regulatory point...; Region: PanK; cd02025
430066009346	ATP-binding site [chemical binding]; other site
430066009347	CoA-binding site [chemical binding]; other site
430066009348	Mg2+-binding site [ion binding]; other site
430066009349	hypothetical protein; Provisional; Region: PRK09256
430066009350	Protein chain release factor B [Translation, ribosomal structure and biogenesis]; Region: PrfB; COG1186
430066009351	Phosphoenolpyruvate carboxykinase; Region: PEPCK_ATP; pfam01293
430066009352	Phosphoenolpyruvate carboxykinase (PEPCK), a critical gluconeogenic enzyme, catalyzes the first committed step in the diversion of tricarboxylic acid cycle intermediates toward gluconeogenesis. It catalyzes the reversible decarboxylation and...; Region: PEPCK_ATP; cd00484
430066009353	active site
430066009354	substrate-binding site [chemical binding]; other site
430066009355	metal-binding site [ion binding]
430066009356	ATP binding site [chemical binding]; other site
430066009357	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
430066009358	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
430066009359	active site
430066009360	phosphorylation site [posttranslational modification]
430066009361	intermolecular recognition site; other site
430066009362	dimerization interface [polypeptide binding]; other site
430066009363	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
430066009364	DNA binding site [nucleotide binding]
430066009365	Sensor N-terminal transmembrane domain; Region: Sensor_TM1; pfam13755
430066009366	Stimulus-sensing domain; Region: Stimulus_sens_1; pfam13756
430066009367	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
430066009368	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
430066009369	dimerization interface [polypeptide binding]; other site
430066009370	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
430066009371	dimer interface [polypeptide binding]; other site
430066009372	phosphorylation site [posttranslational modification]
430066009373	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
430066009374	ATP binding site [chemical binding]; other site
430066009375	Mg2+ binding site [ion binding]; other site
430066009376	G-X-G motif; other site
430066009377	Serine kinase of the HPr protein, regulates carbohydrate metabolism [Signal transduction mechanisms]; Region: HprK; COG1493
430066009378	HprK/P, the bifunctional histidine-containing protein kinase/phosphatase, controls the phosphorylation state of the phosphocarrier protein HPr and regulates the utilization of carbon sources by gram-positive bacteria. It catalyzes both the ATP-dependent...; Region: HprK_C; cd01918
430066009379	Hpr binding site; other site
430066009380	active site
430066009381	homohexamer subunit interaction site [polypeptide binding]; other site
430066009382	PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cd00006
430066009383	active pocket/dimerization site; other site
430066009384	active site
430066009385	phosphorylation site [posttranslational modification]
430066009386	Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367
430066009387	dimerization domain swap beta strand [polypeptide binding]; other site
430066009388	regulatory protein interface [polypeptide binding]; other site
430066009389	active site
430066009390	regulatory phosphorylation site [posttranslational modification]; other site
430066009391	S-adenosyl-L-homocysteine hydrolase; Provisional; Region: PRK05476
430066009392	S-Adenosylhomocysteine Hydrolase, NAD-binding and catalytic domains; Region: SAHH; cd00401
430066009393	homotetramer interface [polypeptide binding]; other site
430066009394	ligand binding site [chemical binding]; other site
430066009395	catalytic site [active]
430066009396	NAD binding site [chemical binding]; other site
430066009397	PAS fold; Region: PAS_7; pfam12860
430066009398	PAS fold; Region: PAS_7; pfam12860
430066009399	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
430066009400	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
430066009401	dimer interface [polypeptide binding]; other site
430066009402	phosphorylation site [posttranslational modification]
430066009403	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
430066009404	ATP binding site [chemical binding]; other site
430066009405	Mg2+ binding site [ion binding]; other site
430066009406	G-X-G motif; other site
430066009407	Predicted ATPase or kinase [General function prediction only]; Region: COG0802
430066009408	Predicted phosphotransferase related to Ser/Thr protein kinases [General function prediction only]; Region: COG3178
430066009409	Phosphotransferase enzyme family; Region: APH; pfam01636
430066009410	Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis/translation initiation factor 2B, gamma/epsilon subunits (eIF-2Bgamma/eIF-2Bepsilon) [Cell envelope biogenesis, outer membrane / Translation, ribosomal structure...; Region: GCD1; COG1208
430066009411	NTP_transferase_like_1 is a member of the nucleotidyl transferase family; Region: NTP_transferase_like_1; cd06422
430066009412	Substrate binding site; other site
430066009413	metal-binding site
430066009414	double-strand break repair protein AddB, alphaproteobacterial type; Region: addB_alphas; TIGR02786
430066009415	RecB family exonuclease [DNA replication, recombination, and repair]; Region: COG2887
430066009416	double-strand break repair helicase AddA, alphaproteobacterial type; Region: addA_alphas; TIGR02784
430066009417	Part of AAA domain; Region: AAA_19; pfam13245
430066009418	Family description; Region: UvrD_C_2; pfam13538
430066009419	PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705
430066009420	TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947
430066009421	Thioredoxin-like; Region: Thioredoxin_8; pfam13905
430066009422	catalytic residues [active]
430066009423	Folylpolyglutamate synthase [Coenzyme metabolism]; Region: FolC; COG0285
430066009424	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
430066009425	acetyl-CoA carboxylase subunit beta; Validated; Region: PRK05654
430066009426	malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682
430066009427	Ttryptophan synthase (TRPS) alpha subunit (TSA). TPRS is a bifunctional tetrameric enzyme (2 alpha and 2 beta subunits) that catalyzes the last two steps of L-tryptophan biosynthesis. Alpha and beta subunit catalyze two distinct reactions which are both...; Region: Tryptophan_synthase_alpha; cd04724
430066009428	substrate binding site [chemical binding]; other site
430066009429	active site
430066009430	catalytic residues [active]
430066009431	heterodimer interface [polypeptide binding]; other site
430066009432	tryptophan synthase, beta subunit; Region: trpB; TIGR00263
430066009433	Tryptophan synthase-beta:  Trptophan synthase is a bifunctional enzyme that catalyses the last two steps in the biosynthesis of L-tryptophan via its alpha and beta reactions. In the alpha reaction, indole 3-glycerol phosphate is cleaved reversibly to...; Region: Trp-synth_B; cd06446
430066009434	pyridoxal 5'-phosphate binding site [chemical binding]; other site
430066009435	catalytic residue [active]
430066009436	Phosphoribosylanthranilate isomerase (PRAI) catalyzes the fourth step of the tryptophan biosynthesis, the conversion of N-(5'- phosphoribosyl)-anthranilate (PRA) to 1-(o-carboxyphenylamino)- 1-deoxyribulose 5-phosphate (CdRP). Most PRAIs are...; Region: PRAI; cd00405
430066009437	active site
430066009438	Uncharacterized conserved protein [Function unknown]; Region: COG1434
430066009439	YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259
430066009440	putative active site [active]
430066009441	Predicted metal-dependent hydrolase [General function prediction only]; Region: COG1451
430066009442	Protein of unknown function (DUF2852); Region: DUF2852; pfam11014
430066009443	Protein of unknown function (DUF2852); Region: DUF2852; pfam11014
430066009444	Uncharacterized protein involved in benzoate metabolism [Secondary metabolites biosynthesis, transport, and catabolism]; Region: BenE; COG3135
430066009445	benzoate transporter; Region: benE; TIGR00843
430066009446	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
430066009447	Novel bacterial esterase that cleaves esters on halogenated cyclic compounds; Region: Esterase_713_like; cl17303
430066009448	Translation initiation factor IF-3, C-terminal domain; Region: IF3_C; pfam00707
430066009449	Putative protein-S-isoprenylcysteine methyltransferase [Posttranslational modification, protein turnover, chaperones]; Region: STE14; COG2020
430066009450	50S ribosomal protein L35; Reviewed; Region: rpmI; PRK00172
430066009451	Ribosomal protein L20; Region: Ribosomal_L20; cd07026
430066009452	23S rRNA binding site [nucleotide binding]; other site
430066009453	L21 binding site [polypeptide binding]; other site
430066009454	L13 binding site [polypeptide binding]; other site
430066009455	Protein Kinases, catalytic domain; Region: PKc_like; cl09925
430066009456	active site
430066009457	ATP binding site [chemical binding]; other site
430066009458	phenylalanyl-tRNA synthetase subunit alpha; Validated; Region: pheS; PRK00488
430066009459	Aminoacyl tRNA synthetase class II, N-terminal domain; Region: Phe_tRNA-synt_N; pfam02912
430066009460	Phenylalanyl-tRNA synthetase (PheRS) alpha chain catalytic core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs. This domain is primarily responsible...; Region: PheRS_alpha_core; cd00496
430066009461	dimer interface [polypeptide binding]; other site
430066009462	motif 1; other site
430066009463	active site
430066009464	motif 2; other site
430066009465	motif 3; other site
430066009466	phenylalanyl-tRNA synthetase subunit beta; Reviewed; Region: pheT; PRK00629
430066009467	tRNA-binding-domain-containing prokaryotic phenylalanly tRNA synthetase (PheRS) beta chain.  PheRS aminoacylate phenylalanine transfer RNAs (tRNAphe). PheRSs belong structurally to class II aminoacyl tRNA synthetases (aaRSs) but, as they aminoacylate...; Region: tRNA_bind_bactPheRS; cd02796
430066009468	putative tRNA-binding site [nucleotide binding]; other site
430066009469	B3/4 domain; Region: B3_4; pfam03483
430066009470	tRNA synthetase B5 domain; Region: B5; smart00874
430066009471	Phenylalanyl-tRNA synthetase (PheRS) beta chain core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure. While class II aaRSs generally aminoacylate the 3'-OH ribose of the appropriate tRNA,  PheRS is an...; Region: PheRS_beta_core; cd00769
430066009472	dimer interface [polypeptide binding]; other site
430066009473	motif 1; other site
430066009474	motif 3; other site
430066009475	motif 2; other site
430066009476	Ferredoxin-fold anticodon binding domain; Region: FDX-ACB; smart00896
430066009477	Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673
430066009478	Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408
430066009479	Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894
430066009480	molecular chaperone DnaK; Provisional; Region: dnaK; PRK00290
430066009481	Nucleotide-binding domain of human HSPA9, Escherichia coli DnaK, and similar proteins; Region: HSPA9-like_NBD; cd11733
430066009482	nucleotide binding site [chemical binding]; other site
430066009483	NEF interaction site [polypeptide binding]; other site
430066009484	SBD interface [polypeptide binding]; other site
430066009485	chaperone protein DnaJ; Provisional; Region: PRK10767
430066009486	DnaJ domain or J-domain.  DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257
430066009487	HSP70 interaction site [polypeptide binding]; other site
430066009488	C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cl03262
430066009489	substrate binding site [polypeptide binding]; other site
430066009490	Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719
430066009491	Zn binding sites [ion binding]; other site
430066009492	C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747
430066009493	dimer interface [polypeptide binding]; other site
430066009494	Phospholipid N-methyltransferase [Lipid metabolism]; Region: COG3963
430066009495	Orotidine 5'-phosphate decarboxylase (ODCase) is a dimeric enzyme that decarboxylates orotidine 5'-monophosphate (OMP) to form uridine 5'-phosphate (UMP), an essential step in the pyrimidine biosynthetic pathway. In mammals, UMP synthase...; Region: OMP_decarboxylase_like; cd04725
430066009496	active site
430066009497	dimer interface [polypeptide binding]; other site
430066009498	Uncharacterized conserved protein [Function unknown]; Region: COG5470
430066009499	Gluconolactonase [Carbohydrate transport and metabolism]; Region: COG3386
430066009500	glutathione synthetase; Provisional; Region: PRK05246
430066009501	Prokaryotic glutathione synthetase, N-terminal domain; Region: GSH-S_N; pfam02951
430066009502	Prokaryotic glutathione synthetase, ATP-grasp domain; Region: GSH-S_ATP; pfam02955
430066009503	Predicted ATPase with chaperone activity [Posttranslational modification, protein turnover, chaperones]; Region: COG0606
430066009504	Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541
430066009505	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
430066009506	Walker A motif; other site
430066009507	ATP binding site [chemical binding]; other site
430066009508	Walker B motif; other site
430066009509	arginine finger; other site
430066009510	Magnesium chelatase, subunit ChlI; Region: Mg_chelatase_2; pfam13335
430066009511	Bacterial transglutaminase-like cysteine proteinase BTLCP; Region: BTLCP; pfam06035
430066009512	Lipoproteins [Cell envelope biogenesis, outer membrane]; Region: RlpA; COG0797
430066009513	Rare lipoprotein A (RlpA)-like double-psi beta-barrel; Region: DPBB_1; pfam03330
430066009514	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2832
430066009515	PBP superfamily domain; Region: PBP_like_2; pfam12849
430066009516	Phosphate ATP-binding cassette transporter; Region: DUF3708; pfam12501
430066009517	ABC-type phosphate transport system, permease component [Inorganic ion transport and metabolism]; Region: PstC; COG0573
430066009518	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
430066009519	dimer interface [polypeptide binding]; other site
430066009520	conserved gate region; other site
430066009521	putative PBP binding loops; other site
430066009522	ABC-ATPase subunit interface; other site
430066009523	Domain of unknown function (DUF3333); Region: DUF3333; pfam11812
430066009524	ABC-type phosphate transport system, permease component [Inorganic ion transport and metabolism]; Region: PstA; COG0581
430066009525	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
430066009526	dimer interface [polypeptide binding]; other site
430066009527	conserved gate region; other site
430066009528	putative PBP binding loops; other site
430066009529	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427
430066009530	ABC-ATPase subunit interface; other site
430066009531	phosphate transporter ATP-binding protein; Provisional; Region: PRK14235
430066009532	ATP-binding cassette domain of the phosphate transport system; Region: ABC_PstB_phosphate_transporter; cd03260
430066009533	Walker A/P-loop; other site
430066009534	ATP binding site [chemical binding]; other site
430066009535	Q-loop/lid; other site
430066009536	ABC transporter signature motif; other site
430066009537	Walker B; other site
430066009538	D-loop; other site
430066009539	H-loop/switch region; other site
430066009540	phosphate transport system regulatory protein PhoU; Region: phoU_full; TIGR02135
430066009541	PhoU domain; Region: PhoU; pfam01895
430066009542	PhoU domain; Region: PhoU; pfam01895
430066009543	phosphate regulon transcriptional regulatory protein PhoB; Region: PhoB; TIGR02154
430066009544	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
430066009545	active site
430066009546	phosphorylation site [posttranslational modification]
430066009547	intermolecular recognition site; other site
430066009548	dimerization interface [polypeptide binding]; other site
430066009549	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
430066009550	DNA binding site [nucleotide binding]
430066009551	Cell wall hydrolyses involved in spore germination [Cell envelope biogenesis, outer membrane]; Region: SleB; COG3773
430066009552	Cell Wall Hydrolase; Region: Hydrolase_2; pfam07486
430066009553	Leucyl aminopeptidase (aminopeptidase T) [Amino acid transport and metabolism]; Region: AmpS; COG2309
430066009554	Thermophilic metalloprotease (M29); Region: Peptidase_M29; pfam02073
430066009555	DNA-binding ferritin-like protein (oxidative damage protectant) [Inorganic ion transport and metabolism]; Region: Dps; COG0783
430066009556	DPS protein, ferritin-like diiron-binding domain; Region: DPS; cd01043
430066009557	dimerization interface [polypeptide binding]; other site
430066009558	DPS ferroxidase diiron center [ion binding]; other site
430066009559	ion pore; other site
430066009560	Inactive homolog of metal-dependent proteases, putative molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: COG1214
430066009561	Glycoprotease family; Region: Peptidase_M22; pfam00814
430066009562	ribosomal-protein-alanine acetyltransferase; Region: rimI; TIGR01575
430066009563	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
430066009564	Coenzyme A binding pocket [chemical binding]; other site
430066009565	1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204
430066009566	Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989
430066009567	putative acyl-acceptor binding pocket; other site
430066009568	(dimethylallyl)adenosine tRNA methylthiotransferase; Provisional; Region: PRK14325
430066009569	Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919
430066009570	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
430066009571	FeS/SAM binding site; other site
430066009572	TRAM domain; Region: TRAM; cl01282
430066009573	Phosphate starvation-inducible protein PhoH, predicted ATPase [Signal transduction mechanisms]; Region: PhoH; COG1702
430066009574	PhoH-like protein; Region: PhoH; pfam02562
430066009575	Predicted metal-dependent hydrolase [General function prediction only]; Region: COG0319
430066009576	Putative Mg2+ and Co2+ transporter CorC [Inorganic ion transport and metabolism]; Region: CorC; COG4535
430066009577	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590
430066009578	Transporter associated domain; Region: CorC_HlyC; smart01091
430066009579	apolipoprotein N-acyltransferase; Reviewed; Region: lnt; PRK00302
430066009580	Apolipoprotein N-acyl transferase (class 9 nitrilases); Region: ALP_N-acyl_transferase; cd07571
430066009581	putative active site [active]
430066009582	catalytic triad [active]
430066009583	putative dimer interface [polypeptide binding]; other site
430066009584	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
430066009585	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
430066009586	non-specific DNA binding site [nucleotide binding]; other site
430066009587	salt bridge; other site
430066009588	sequence-specific DNA binding site [nucleotide binding]; other site
430066009589	S-adenosylmethionine synthetase; Validated; Region: PRK05250
430066009590	S-adenosylmethionine synthetase, N-terminal domain; Region: S-AdoMet_synt_N; pfam00438
430066009591	S-adenosylmethionine synthetase, central domain; Region: S-AdoMet_synt_M; pfam02772
430066009592	S-adenosylmethionine synthetase, C-terminal domain; Region: S-AdoMet_synt_C; pfam02773
430066009593	Predicted S-adenosylmethionine-dependent methyltransferase [General function prediction only]; Region: COG0220
430066009594	ribosome maturation protein RimP; Reviewed; Region: PRK00092
430066009595	Sm and related proteins; Region: Sm_like; cl00259
430066009596	Bacillus subtilis YxlS-like, C-terminal domain; Region: YlxS_C; cd01734
430066009597	putative oligomer interface [polypeptide binding]; other site
430066009598	putative RNA binding site [nucleotide binding]; other site
430066009599	transcription elongation factor NusA; Validated; Region: nusA; PRK09202
430066009600	NusA N-terminal domain; Region: NusA_N; pfam08529
430066009601	S1_NusA: N-utilizing substance A protein (NusA), S1-like RNA-binding domain. S1-like RNA-binding domains are found in a wide variety of RNA-associated proteins. NusA is a transcription elongation factor containing an N-terminal catalytic domain and three...; Region: S1_NusA; cd04455
430066009602	RNA binding site [nucleotide binding]; other site
430066009603	homodimer interface [polypeptide binding]; other site
430066009604	NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134
430066009605	G-X-X-G motif; other site
430066009606	NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134
430066009607	G-X-X-G motif; other site
430066009608	transcription termination factor NusA, C-terminal duplication; Region: nusA_Cterm_rpt; TIGR01954
430066009609	hypothetical protein; Provisional; Region: PRK09190
430066009610	Ylxr homologs; group of conserved hypothetical bacterial proteins of unknown function; structure revealed putative RNA binding cleft; proteins are encoded by an operon that includes other proteins involved in transcription and/or translation; Region: YlxR; cd00279
430066009611	putative RNA binding cleft [nucleotide binding]; other site
430066009612	Ribosomal protein L7Ae/L30e/S12e/Gadd45 family; Region: Ribosomal_L7Ae; cl00600
430066009613	Bacterial translation initiation factor IF-2 associated region; Region: IF2_assoc; pfam08364
430066009614	Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760
430066009615	Translation initiation factor 2 (IF-2; GTPase) [Translation, ribosomal structure and biogenesis]; Region: InfB; COG0532
430066009616	Initiation Factor 2 (IF2)/ eukaryotic Initiation Factor 5B (eIF5B) family; Region: IF2_eIF5B; cd01887
430066009617	G1 box; other site
430066009618	putative GEF interaction site [polypeptide binding]; other site
430066009619	GTP/Mg2+ binding site [chemical binding]; other site
430066009620	Switch I region; other site
430066009621	G2 box; other site
430066009622	G3 box; other site
430066009623	Switch II region; other site
430066009624	G4 box; other site
430066009625	G5 box; other site
430066009626	This family represents the domain II of bacterial Initiation Factor 2 (IF2) and its eukaryotic mitochondrial homologue mtIF2. IF2, the largest initiation factor is an essential GTP binding protein. In E. coli three natural forms of IF2 exist in the cell; Region: IF2_mtIF2_II; cd03702
430066009627	Translation-initiation factor 2; Region: IF-2; pfam11987
430066009628	mtIF2_IVc: this family represents the C2 subdomain of domain IV of mitochondrial translation initiation factor 2 (mtIF2) which adopts a beta-barrel fold displaying a high degree of structural similarity with domain II of the translation elongation factor...; Region: mtIF2_IVc; cd03692
430066009629	ribosome-binding factor A; Validated; Region: rbfA; PRK00521
430066009630	tRNA pseudouridine synthase B; Provisional; Region: truB; PRK05389
430066009631	Pseudouridine synthase, Escherichia coli TruB like; Region: PseudoU_synth_EcTruB; cd02573
430066009632	RNA binding site [nucleotide binding]; other site
430066009633	active site
430066009634	Pseudouridine synthase II TruB, C-terminal; Region: TruB-C_2; pfam09157
430066009635	Ribosomal protein S15 (prokaryotic)_S13 (eukaryotic) binds the central domain of 16S rRNA and is required for assembly of the small ribosomal subunit and for intersubunit association, thus representing a key element in the assembly of the whole ribosome; Region: Ribosomal_S15p_S13e; cd00353
430066009636	16S/18S rRNA binding site [nucleotide binding]; other site
430066009637	S13e-L30e interaction site [polypeptide binding]; other site
430066009638	25S rRNA binding site [nucleotide binding]; other site
430066009639	polynucleotide phosphorylase/polyadenylase; Provisional; Region: PRK11824
430066009640	Polyribonucleotide nucleotidyltransferase, repeat 1; Region: RNase_PH_PNPase_1; cd11363
430066009641	RNase E interface [polypeptide binding]; other site
430066009642	trimer interface [polypeptide binding]; other site
430066009643	Polyribonucleotide nucleotidyltransferase, RNA binding domain; Region: PNPase; pfam03726
430066009644	Polyribonucleotide nucleotidyltransferase, repeat 2; Region: RNase_PH_PNPase_2; cd11364
430066009645	RNase E interface [polypeptide binding]; other site
430066009646	trimer interface [polypeptide binding]; other site
430066009647	active site
430066009648	Polynucleotide phosphorylase (PNPase) K homology RNA-binding domain (KH). PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA in prokaryotes and plant chloroplasts. The C-terminal region of PNPase contains domains homologous to...; Region: PNPase_KH; cd02393
430066009649	putative nucleic acid binding region [nucleotide binding]; other site
430066009650	G-X-X-G motif; other site
430066009651	S1_PNPase: Polynucleotide phosphorylase (PNPase), ), S1-like RNA-binding domain. PNPase  is a polyribonucleotide nucleotidyl transferase that degrades mRNA. It is a trimeric multidomain protein. The C-terminus contains the S1 domain which binds ssRNA; Region: S1_PNPase; cd04472
430066009652	RNA binding site [nucleotide binding]; other site
430066009653	domain interface; other site
430066009654	16S RNA G1207 methylase RsmC [Translation, ribosomal structure and biogenesis]; Region: RsmC; COG2813
430066009655	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173
430066009656	16S RNA G1207 methylase RsmC [Translation, ribosomal structure and biogenesis]; Region: RsmC; COG2813
430066009657	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173
430066009658	enoyl-(acyl carrier protein) reductase; Provisional; Region: PRK06505
430066009659	Enoyl acyl carrier protein (ACP) reductase (ENR), divergent SDR; Region: ENR_SDR; cd05372
430066009660	NAD binding site [chemical binding]; other site
430066009661	homotetramer interface [polypeptide binding]; other site
430066009662	homodimer interface [polypeptide binding]; other site
430066009663	substrate binding site [chemical binding]; other site
430066009664	active site
430066009665	3-oxoacyl-(acyl carrier protein) synthase I; Reviewed; Region: PRK07967
430066009666	Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834
430066009667	dimer interface [polypeptide binding]; other site
430066009668	active site
430066009669	FabA, beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase: Bacterial protein of the type II, fatty acid synthase system that binds ACP and catalyzes both dehydration and isomerization reactions, apparently in the same active site. The FabA...; Region: FabA; cd01287
430066009670	active site 1 [active]
430066009671	dimer interface [polypeptide binding]; other site
430066009672	active site 2 [active]
430066009673	Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153
430066009674	metal binding site 2 [ion binding]; metal-binding site
430066009675	putative DNA binding helix; other site
430066009676	metal binding site 1 [ion binding]; metal-binding site
430066009677	dimer interface [polypeptide binding]; other site
430066009678	structural Zn2+ binding site [ion binding]; other site
430066009679	ABC-type metal ion transport system, periplasmic component/surface antigen [Inorganic ion transport and metabolism]; Region: NlpA; COG1464
430066009680	NLPA lipoprotein; Region: Lipoprotein_9; pfam03180
430066009681	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3807
430066009682	Bacterial SH3 domain; Region: SH3_4; pfam06347
430066009683	Bacterial SH3 domain; Region: SH3_4; pfam06347
430066009684	Lactate dehydrogenase and related dehydrogenases [Energy production and conversion / Coenzyme metabolism / General function prediction only]; Region: LdhA; COG1052
430066009685	D-glycerate dehydrogenase/hydroxypyruvate reductase (GDH); Region: GDH; cd05301
430066009686	dimerization interface [polypeptide binding]; other site
430066009687	ligand binding site [chemical binding]; other site
430066009688	NADP binding site [chemical binding]; other site
430066009689	catalytic site [active]
430066009690	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
430066009691	Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791
430066009692	NlpC/P60 family; Region: NLPC_P60; cl17555
430066009693	Transcriptional regulators [Transcription]; Region: MarR; COG1846
430066009694	MarR family; Region: MarR; pfam01047
430066009695	multifunctional aminopeptidase A; Provisional; Region: PRK00913
430066009696	Cytosol aminopeptidase family, N-terminal and catalytic domains.  Family M17 contains zinc- and manganese-dependent exopeptidases ( EC  3.4.11.1), including leucine aminopeptidase. They catalyze removal of amino acids from the N-terminus of a protein and...; Region: Peptidase_M17; cd00433
430066009697	interface (dimer of trimers) [polypeptide binding]; other site
430066009698	Substrate-binding/catalytic site; other site
430066009699	Zn-binding sites [ion binding]; other site
430066009700	formamidopyrimidine/5-formyluracil/ 5-hydroxymethyluracil DNA glycosylase; Validated; Region: PRK01103
430066009701	N-terminal domain of Escherichia coli Fpg1/MutM and related bacterial DNA glycosylases; Region: EcFpg-like_N; cd08966
430066009702	DNA binding site [nucleotide binding]
430066009703	catalytic residue [active]
430066009704	H2TH interface [polypeptide binding]; other site
430066009705	putative catalytic residues [active]
430066009706	turnover-facilitating residue; other site
430066009707	intercalation triad [nucleotide binding]; other site
430066009708	8OG recognition residue [nucleotide binding]; other site
430066009709	putative reading head residues; other site
430066009710	Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831
430066009711	Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827
430066009712	enoyl-CoA hydratase; Provisional; Region: PRK05862
430066009713	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
430066009714	substrate binding site [chemical binding]; other site
430066009715	oxyanion hole (OAH) forming residues; other site
430066009716	trimer interface [polypeptide binding]; other site
430066009717	30S ribosomal protein S20; Reviewed; Region: rpsT; PRK00239